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fludroxycortide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| corticosteroids, except prednisolone derivatives | 1217 | 1524-88-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A corticosteroid used topically in the treatment of various skin disorders. It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive. (From Martindale, The Extra Pharmacopoeia, 30th ed, p733)
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 1.872 | Moderate | 0.75 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 6.039 | Moderate | 0.75 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 35.400 | 10^-6 cm/s | Moderate | 0.75 |
| dh-clint | Dog hepatocyte intrinsic clearance | 8.770 | uL/min/10^6 cells | Moderate | 0.75 |
| dppb | Dog plasma protein binding (% unbound) | 28.520 | % | Moderate | 0.75 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 38.850 | % | Moderate | 0.75 |
| herg | hERG pIC50 | 4.260 | pIC50 | Moderate | 0.75 |
| hh-clint | Human hepatocyte intrinsic clearance | 6.516 | uL/min/10^6 cells | Moderate | 0.75 |
| hlm-clint | Human liver microsomal intrinsic clearance | 32.810 | uL/min/mg protein | Moderate | 0.75 |
| hppb | Human plasma protein binding (% unbound) | 28.100 | % | Moderate | 0.75 |
| kinase-safety-class | ACVR2B,CAMK2D,CDK5,EIF2AK3,GRK2,ITK,PDK1,PDK2,PDK4,PRKDC | 10 | |||
| kinase-selectivity-class | GRK2 | 1 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 9.397 | Moderate | 0.75 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 28.184 | Moderate | 0.75 | |
| mppb | Mouse plasma protein binding (% unbound) | 26.320 | Moderate | 0.75 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 16.943 | Moderate | 0.75 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 34.990 | % | Moderate | 0.75 |
| rh-clint | Rat hepatocyte intrinsic clearance | 38.726 | uL/min/10^6 cells | Moderate | 0.75 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 75.340 | % | Moderate | 0.75 |
| rppb | Rat plasma protein binding (% unbound) | 19.460 | % | Moderate | 0.75 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 788.860 | uM | Moderate | 0.75 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 19, 1963 | FDA | AQUA PHARMS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D07AC07 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III) |
| ATC | D07CC03 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS Corticosteroids, potent, combinations with antibiotics |
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D006728 | Hormones |
Related Drugs by ATC class:
D07AC Corticosteroids, potent (group III) 20 drugs
D07CC Corticosteroids, potent, combinations with antibiotics 5 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Atopic dermatitis | indication | 24079001 | DOID:3310 |
| Contact dermatitis | indication | 40275004 | DOID:2773 |
| Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
| Lichen simplex chronicus | indication | 53891004 | |
| Granuloma annulare | indication | 65508009 | DOID:3777 |
| Pruritus ani | indication | 90446007 | |
| Discoid lupus erythematosus | indication | 200938002 | |
| Plaque psoriasis | indication | 200965009 | |
| Scalp psoriasis | indication | 238608008 | |
| Pruritus of genital organs | indication | 267802000 | |
| Eruption of skin | indication | 271807003 | DOID:0050486 |
| Primary cutaneous T-cell lymphoma | indication | 400122007 | |
| Telangiectasia disorder | contraindication | 247479008 | |
| Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
| Atrophoderma | contraindication | 399979006 | |
| Peripheral vascular disease | contraindication | 400047006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.78 | acidic |
| pKa2 | 13.87 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | Ki | 8.70 | DRUG MATRIX | CHEMBL | |||
| Progesterone receptor | Transcription factor | Ki | 7.66 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| 4019050 | VUID |
| N0000147319 | NUI |
| D00328 | KEGG_DRUG |
| 4019050 | VANDF |
| C0016374 | UMLSCUI |
| CHEBI:5127 | CHEBI |
| CHEMBL1201012 | ChEMBL_ID |
| DB00846 | DRUGBANK_ID |
| 7606 | IUPHAR_LIGAND_ID |
| 15209 | PUBCHEM_CID |
| 4500 | RXNORM |
| 240649 | MMSL |
| 4751 | MMSL |
| 002192 | NDDF |
| 16522004 | SNOMEDCT_US |
| 71455005 | SNOMEDCT_US |
| D005478 | MESH_DESCRIPTOR_UI |
| 1123 | INN_ID |
| 8EUL29XUQT | UNII |
| 8EUL29XUQT | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Cordran | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-5870 | TAPE | 4 ug | TOPICAL | NDA | 19 sections |
| CORDRAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16110-587 | TAPE | 4 ug | TOPICAL | NDA | 12 sections |
| Flurandrenolide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45802-928 | LOTION | 0.50 mg | TOPICAL | ANDA | 19 sections |
| Flurandrenolide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52565-017 | OINTMENT | 0.50 mg | TOPICAL | ANDA | 18 sections |
| Flurandrenolide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-8657 | LOTION | 0.50 mg | TOPICAL | ANDA | 19 sections |
| Flurandrenolide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72162-1439 | LOTION | 0.50 mg | TOPICAL | ANDA | 19 sections |
| CORDRAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 74157-130 | CREAM | 0.50 mg | TOPICAL | NDA | 21 sections |
| CORDRAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 74157-180 | CREAM | 0.50 mg | TOPICAL | NDA | 21 sections |