fludroxycortide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 1217 1524-88-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • flurandrenolide
  • fluadrenolone
  • fludroxycortide
  • fluorandrenolone
  • fluorandrenolone acetonide
  • fluoroandrenolone acetonide
  • flurandrenolone
  • flurandrenolone acetonide
A corticosteroid used topically in the treatment of various skin disorders. It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive. (From Martindale, The Extra Pharmacopoeia, 30th ed, p733)
  • Molecular weight: 436.52
  • Formula: C24H33FO6
  • CLOGP: 2.87
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 93.06
  • ALOGS: -3.88
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 19, 1963 FDA AQUA PHARMS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AC07 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
ATC D07CC03 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, potent, combinations with antibiotics
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Lichen simplex chronicus indication 53891004
Granuloma annulare indication 65508009 DOID:3777
Pruritus ani indication 90446007
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Scalp psoriasis indication 238608008
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Primary cutaneous T-cell lymphoma indication 400122007
Telangiectasia disorder contraindication 247479008
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.78 acidic
pKa2 13.87 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST Ki 8.70 DRUG MATRIX CHEMBL
Progesterone receptor Transcription factor Ki 7.66 DRUG MATRIX

External reference:

IDSource
4019050 VUID
N0000147319 NUI
D00328 KEGG_DRUG
4019050 VANDF
C0016374 UMLSCUI
CHEBI:5127 CHEBI
CHEMBL1201012 ChEMBL_ID
DB00846 DRUGBANK_ID
7606 IUPHAR_LIGAND_ID
8EUL29XUQT UNII
15209 PUBCHEM_CID
4500 RXNORM
240649 MMSL
4751 MMSL
002192 NDDF
16522004 SNOMEDCT_US
71455005 SNOMEDCT_US
D005478 MESH_DESCRIPTOR_UI
1123 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cordran HUMAN PRESCRIPTION DRUG LABEL 1 0023-5870 TAPE 4 ug TOPICAL NDA 19 sections
Cordran HUMAN PRESCRIPTION DRUG LABEL 1 16110-026 OINTMENT 0.50 mg TOPICAL NDA 21 sections
Cordran HUMAN PRESCRIPTION DRUG LABEL 1 16110-034 CREAM 0.25 mg TOPICAL NDA 21 sections
Cordran HUMAN PRESCRIPTION DRUG LABEL 1 16110-035 CREAM 0.50 mg TOPICAL NDA 21 sections
Cordran HUMAN PRESCRIPTION DRUG LABEL 1 16110-052 LOTION 0.50 mg TOPICAL NDA 19 sections
CORDRAN HUMAN PRESCRIPTION DRUG LABEL 1 16110-587 TAPE 4 ug TOPICAL NDA 12 sections
Flurandrenolide Cream HUMAN PRESCRIPTION DRUG LABEL 1 24470-919 CREAM 0.50 mg TOPICAL ANDA 11 sections
Flurandrenolide HUMAN PRESCRIPTION DRUG LABEL 1 24470-921 LOTION 0.50 mg TOPICAL ANDA 10 sections
Flurandrenolide HUMAN PRESCRIPTION DRUG LABEL 1 24470-921 LOTION 0.50 mg TOPICAL ANDA 10 sections
Flurandrenolide HUMAN PRESCRIPTION DRUG LABEL 1 45802-928 LOTION 0.50 mg TOPICAL ANDA 19 sections
Flurandrenolide HUMAN PRESCRIPTION DRUG LABEL 1 51672-5298 LOTION 0.50 mg TOPICAL NDA 21 sections
Flurandrenolide HUMAN PRESCRIPTION DRUG LABEL 1 51672-5301 CREAM 0.50 mg TOPICAL NDA 21 sections
flurandrenolide HUMAN PRESCRIPTION DRUG LABEL 1 51862-158 OINTMENT 0.50 mg TOPICAL ANDA 21 sections
Flurandrenolide HUMAN PRESCRIPTION DRUG LABEL 1 52565-017 OINTMENT 0.50 mg TOPICAL ANDA 18 sections
Nolix HUMAN PRESCRIPTION DRUG LABEL 1 57893-310 CREAM 0.50 mg TOPICAL ANDA 10 sections
Nolix HUMAN PRESCRIPTION DRUG LABEL 1 57893-311 LOTION 0.50 mg TOPICAL ANDA 9 sections
Nolix HUMAN PRESCRIPTION DRUG LABEL 1 57893-311 LOTION 0.50 mg TOPICAL ANDA 9 sections
Flurandrenolide HUMAN PRESCRIPTION DRUG LABEL 1 63629-8657 LOTION 0.50 mg TOPICAL ANDA 19 sections
Flurandrenolide HUMAN PRESCRIPTION DRUG LABEL 1 63629-8657 LOTION 0.50 mg TOPICAL ANDA 19 sections