fluclorolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
steroids not used as glucocorticosteroids 4546 3693-38-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fluclorolone
  • Molecular weight: 447.32
  • Formula: C21H25Cl2FO5
  • CLOGP: 2.70
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -4.35
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.468 Moderate 0.75
caco2-efflux Caco-2 efflux ratio (BA/AB) 6.637 Moderate 0.75
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 31.769 10^-6 cm/s Moderate 0.75
dh-clint Dog hepatocyte intrinsic clearance 3.750 uL/min/10^6 cells Moderate 0.75
dppb Dog plasma protein binding (% unbound) 7.470 % Moderate 0.75
fcs-ppb Fetal calf serum protein binding (% unbound) 12.180 % Moderate 0.75
herg hERG pIC50 4.660 pIC50 Moderate 0.75
hh-clint Human hepatocyte intrinsic clearance 3.793 uL/min/10^6 cells Moderate 0.75
hlm-clint Human liver microsomal intrinsic clearance 10.069 uL/min/mg protein Moderate 0.75
hppb Human plasma protein binding (% unbound) 5.810 % Moderate 0.75
kinase-safety-class ACVR2B,CDK5,EIF2AK3,GRK2,ITK,MAPK10,PDK1,PDK2,PDK4,PRKDC 10
kinase-selectivity-class GRK2,MAP2K6,PDK1 3
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 13.428 Moderate 0.75
mh-clint Mouse hepatocyte intrinsic clearance 14.928 Moderate 0.75
mppb Mouse plasma protein binding (% unbound) 7.340 Moderate 0.75
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 29.309 Moderate 0.75
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 10.560 % Moderate 0.75
rh-clint Rat hepatocyte intrinsic clearance 25.351 uL/min/10^6 cells Moderate 0.75
rh-fuinc Rat hepatocyte fraction unbound in incubation 49.420 % Moderate 0.75
rppb Rat plasma protein binding (% unbound) 6.040 % Moderate 0.75
solubility-dd Solubility at pH 7.4 in DMSO 106.170 uM Moderate 0.75

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AC02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)

Related Drugs by ATC class:

D07AC Corticosteroids, potent (group III) 20 drugs
amcinonidebeclometasone dipropionatebetamethasonebudesonidedesoximetasonediflorasone diacetatediflucortolonedifluprednatefludroxycortidefluocinolone acetonidefluocinonidefluocortolone show all 20 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.84 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
CHEBI:135986 CHEBI
CHEMBL3707231 ChEMBL_ID
DB13856 DRUGBANK_ID
036B9W83KK UNII
108091 RXNORM
116583005 SNOMEDCT_US
419790004 SNOMEDCT_US
C0360537 UMLSCUI
76962649 PUBCHEM_CID

Pharmaceutical products:

None