sodium phosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4219	7558-79-4

Description:

Molecule	Description
Synonyms: sodium phosphate, monobasic anhydrous disodium phosphate sodium phosphate sodium phosphate, dibasic, heptahydrate sodium phosphate, dibasic sodium phosphate, dibasic anhydrous sodium phosphate, monobasic, anhydrous	Molecular weight: 141.96 Formula: HNa2O4P CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 83.42 ALOGS: ROTB: None

Molecule

Description

Synonyms:

sodium phosphate, monobasic anhydrous
disodium phosphate
sodium phosphate
sodium phosphate, dibasic, heptahydrate
sodium phosphate, dibasic
sodium phosphate, dibasic anhydrous
sodium phosphate, monobasic, anhydrous

Molecular weight: 141.96
Formula: HNa2O4P
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 83.42
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
50	g	O
8	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
May 10, 1983	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Intestinal pseudo-obstruction	75.04	15.38	17	5284	895	63482826
Cytokine release syndrome	40.42	15.38	21	5280	14293	63469428
Acute phosphate nephropathy	34.55	15.38	5	5296	17	63483704
Loss of bladder sensation	29.62	15.38	5	5296	54	63483667
Diarrhoea	27.45	15.38	125	5176	715241	62768480
Food refusal	25.57	15.38	6	5295	369	63483352
Mutism	24.73	15.38	8	5293	1622	63482099
Neutropenic sepsis	24.69	15.38	16	5285	16422	63467299
Cholelithiasis	22.93	15.38	23	5278	43902	63439819
Hypokalaemia	22.59	15.38	35	5266	103769	63379952

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	147.76	19.66	52	4610	8549	34943720
Appendicitis	123.62	19.66	53	4609	14754	34937515
Aplastic anaemia	116.14	19.66	45	4617	9671	34942598
Cardiogenic shock	96.82	19.66	54	4608	26564	34925705
Stress	87.64	19.66	53	4609	30294	34921975
Ventricular fibrillation	81.91	19.66	46	4616	22908	34929361
Ascites	75.84	19.66	57	4605	46514	34905755
Abdominal distension	74.64	19.66	62	4600	58430	34893839
Blood phosphorus increased	62.30	19.66	27	4635	7694	34944575
Lymphocyte count decreased	61.42	19.66	38	4624	22584	34929685

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	156.23	15.22	52	8982	8499	79726855
Aplastic anaemia	118.86	15.22	52	8982	17853	79717501
Appendicitis	114.51	15.22	53	8981	20741	79714613
Cardiogenic shock	92.06	15.22	58	8976	41856	79693498
Ventricular fibrillation	77.26	15.22	47	8987	31879	79703475
Abdominal distension	72.28	15.22	78	8956	119572	79615782
Sepsis	61.90	15.22	110	8924	269318	79466036
Ascites	59.76	15.22	57	8977	75505	79659849
Blood phosphorus increased	58.91	15.22	27	9007	10320	79725034
Lymphocyte count decreased	58.36	15.22	46	8988	47243	79688111

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A06AD17	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Osmotically acting laxatives
ATC	A06AG01	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Enemas
ATC	B05XA09	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS I.V. SOLUTION ADDITIVES Electrolyte solutions
ATC	V03AG05	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Drugs for treatment of hypercalcemia

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Constipation	indication	14760008	DOID:2089

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	5.01		CHEMBL

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External reference:

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ID	Source
001188	NDDF
006672	NDDF
006674	NDDF
007397	NDDF
1109	MMSL
12492	MMSL
221090	RXNORM
24243	PUBCHEM_CID
4017620	VANDF
4018050	VUID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Fleet	HUMAN OTC DRUG LABEL	2	0132-0201	ENEMA	7 g	RECTAL	OTC monograph not final	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0201	ENEMA	7 g	RECTAL	OTC monograph not final	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0201	ENEMA	7 g	RECTAL	OTC monograph not final	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0201	ENEMA	7 g	RECTAL	OTC monograph not final	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0525	ENEMA	7 g	RECTAL	Export only	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0525	ENEMA	7 g	RECTAL	Export only	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0527	ENEMA	7 g	RECTAL	Export only	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0527	ENEMA	7 g	RECTAL	Export only	12 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0528	ENEMA	7 g	RECTAL	Export only	11 sections
Fleet	HUMAN OTC DRUG LABEL	2	0132-0528	ENEMA	7 g	RECTAL	Export only	11 sections

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