bisacodyl 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
vasodilators 375 603-50-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bisacodyl
  • brocalax
  • dulcolax
A diphenylmethane stimulant laxative used for the treatment of CONSTIPATION and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871)
  • Molecular weight: 361.40
  • Formula: C22H19NO4
  • CLOGP: 2.85
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 65.49
  • ALOGS: -5.46
  • ROTB: 7
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg R

ADMET properties:

PropertyValueReference
BA (Bioavailability) 15 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility) 0.00 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.928 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.232 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 60.117 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 421.697 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 4.470 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 6.860 % High 1
herg hERG pIC50 4.544 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 650.130 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 234.963 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 4.340 % High 1
kinase-safety-class ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PRKDC,STK33,TEK,TTK 27
kinase-selectivity-class MAP2K6 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.199 High 1
mh-clint Mouse hepatocyte intrinsic clearance 587.489 High 1
mppb Mouse plasma protein binding (% unbound) 13.550 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.592 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 18.810 % High 1
rh-clint Rat hepatocyte intrinsic clearance 346.737 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 82.750 % High 1
rppb Rat plasma protein binding (% unbound) 8.150 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 65.464 uM High 1

Approvals:

DateAgencyCompanyOrphan
May 10, 2004 FDA BRAINTREE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 880.12 11.45 434 52547 37536 90537930
Schizophrenia 473.63 11.45 212 52769 14702 90560764
Creatinine renal clearance decreased 464.59 11.45 225 52756 18674 90556792
Sedation complication 463.15 11.45 217 52764 16727 90558739
Orthostatic hypotension 442.45 11.45 286 52695 41541 90533925
Hypomania 393.64 11.45 160 52821 8737 90566729
Chronic sinusitis 390.65 11.45 216 52765 23586 90551880
Blood calcium decreased 386.37 11.45 233 52748 29949 90545517
Constipation 380.13 11.45 627 52354 279768 90295698
Jaundice cholestatic 368.31 11.45 158 52823 9885 90565581
Cognitive disorder 365.71 11.45 312 52669 69095 90506371
Sedation 364.53 11.45 268 52713 47903 90527563
Vaginal flatulence 327.39 11.45 156 52825 12482 90562984
Proctitis 322.64 11.45 164 52817 15095 90560371
Female genital tract fistula 298.27 11.45 164 52817 17704 90557762
Paraesthesia oral 294.85 11.45 200 52781 31459 90544007
Radiculopathy 290.18 11.45 163 52818 18342 90557124
Balance disorder 285.70 11.45 317 52664 96763 90478703
Vaginal discharge 279.84 11.45 162 52819 19302 90556164
Cholelithiasis 270.36 11.45 233 52748 52273 90523193
Depressed level of consciousness 264.56 11.45 266 52715 72518 90502948
Psychotic disorder 250.42 11.45 180 52801 31050 90544416
Procedural pain 248.73 11.45 184 52797 33176 90542290
Blood bilirubin increased 228.05 11.45 195 52786 43275 90532191
Oral candidiasis 219.29 11.45 175 52806 35280 90540186
Asthma-chronic obstructive pulmonary disease overlap syndrome 212.92 11.45 87 52894 4812 90570654
Total lung capacity increased 210.86 11.45 87 52894 4934 90570532
Hypotension 179.22 11.45 505 52476 324892 90250574
Colitis 178.07 11.45 212 52769 69730 90505736
Synovitis 177.62 11.45 3 52978 329749 90245717
Systemic lupus erythematosus 174.54 11.45 9 52972 361887 90213579
Haematochezia 169.21 11.45 208 52773 70705 90504761
Glossodynia 169.03 11.45 4 52977 321775 90253691
Pemphigus 168.20 11.45 5 52976 326859 90248607
Hepatotoxicity 165.53 11.45 167 52814 45675 90529791
Bronchiectasis 161.59 11.45 121 52860 22209 90553257
Frequent bowel movements 152.26 11.45 177 52804 56758 90518708
Nasal polyps 152.26 11.45 89 52892 10791 90564675
Sarcoidosis 151.19 11.45 88 52893 10585 90564881
Cardiac murmur 148.44 11.45 106 52875 18088 90557378
Rheumatoid arthritis 147.51 11.45 19 52962 362595 90212871
Colitis ulcerative 145.76 11.45 178 52803 60088 90515378
Arthropathy 142.39 11.45 22 52959 366220 90209246
Joint swelling 140.95 11.45 59 52922 503241 90072225
Contraindicated product administered 137.14 11.45 14 52967 320125 90255341
Pericarditis 135.89 11.45 5 52976 270146 90305320
Alopecia 132.38 11.45 62 52919 495009 90080457
Wound 130.42 11.45 13 52968 302967 90272499
Rectal haemorrhage 129.64 11.45 198 52783 82546 90492920
Rhinitis allergic 128.29 11.45 94 52887 16691 90558775
Fall 124.38 11.45 584 52397 481226 90094240
Abdominal pain 121.29 11.45 505 52476 395216 90180250
Treatment failure 118.70 11.45 18 52963 303910 90271556
Helicobacter infection 118.41 11.45 3 52978 226847 90348619
Chronic obstructive pulmonary disease 117.53 11.45 178 52803 73651 90501815
Psoriatic arthropathy 106.00 11.45 7 52974 228328 90347138
Therapeutic product effect decreased 102.71 11.45 19 52962 277552 90297914
Maternal exposure during pregnancy 101.07 11.45 42 52939 360021 90215445
Anaemia 100.92 11.45 441 52540 352361 90223105
Rash 99.72 11.45 197 52784 795903 89779563
Arthralgia 97.20 11.45 193 52788 778329 89797137
Nausea 93.74 11.45 1025 51956 1109291 89466175
Folliculitis 92.72 11.45 7 52974 204346 90371120
Creatinine renal clearance increased 89.56 11.45 42 52939 3239 90572227
Renal function test abnormal 88.09 11.45 54 52927 7137 90568329
Impaired healing 86.70 11.45 16 52965 234183 90341283
Fibromyalgia 85.80 11.45 10 52971 206259 90369207
Swelling 85.10 11.45 72 52909 418986 90156480
Lung neoplasm malignant 83.20 11.45 86 52895 24187 90551279
Multiple drug therapy 81.71 11.45 51 52930 6958 90568508
Swollen tongue 80.62 11.45 116 52865 45840 90529626
Abdominal discomfort 77.76 11.45 99 52882 477229 90098237
Irritable bowel syndrome 77.16 11.45 14 52967 207434 90368032
Exposure during pregnancy 75.06 11.45 23 52958 238387 90337079
Type 2 diabetes mellitus 74.98 11.45 14 52967 203230 90372236
Urticaria 70.80 11.45 48 52933 312686 90262780
Toxicity to various agents 70.54 11.45 344 52637 287502 90287964
Nasopharyngitis 68.85 11.45 82 52899 407022 90168444
Sinusitis 68.35 11.45 60 52921 343028 90232438
Intestinal pseudo-obstruction 65.80 11.45 25 52956 1138 90574328
Product use issue 64.16 11.45 59 52922 329860 90245606
Infection 62.22 11.45 72 52909 362022 90213444
Total lung capacity decreased 61.03 11.45 34 52947 3761 90571705
Peripheral swelling 60.92 11.45 92 52889 413014 90162452
Liver injury 58.30 11.45 14 52967 170553 90404913
Joint range of motion decreased 57.86 11.45 6 52975 135637 90439829
Weight increased 57.00 11.45 98 52883 417829 90157637
Drug hypersensitivity 56.81 11.45 116 52865 463493 90111973
Inflammation 56.62 11.45 17 52964 178575 90396891
Dysphonia 56.18 11.45 118 52863 62966 90512500
Weight decreased 55.98 11.45 397 52584 379513 90195953
Gastrointestinal disorder 55.98 11.45 41 52940 256646 90318820
Blister 53.98 11.45 42 52939 254956 90320510
Discomfort 53.39 11.45 49 52932 274286 90301180
Bronchopulmonary aspergillosis allergic 53.20 11.45 31 52950 3735 90571731
Blood calcium increased 51.14 11.45 48 52933 12010 90563456
Hypoxia 50.61 11.45 123 52858 72276 90503190
Ill-defined disorder 49.56 11.45 23 52958 184868 90390598
Oedema peripheral 48.69 11.45 287 52694 257628 90317838
Lung opacity 46.23 11.45 34 52947 6068 90569398
Therapeutic product effect incomplete 46.23 11.45 230 52751 193666 90381800
Pneumonia 45.94 11.45 572 52409 637487 89937979
Facet joint syndrome 45.69 11.45 3 52978 98386 90477080
Faecaloma 45.16 11.45 42 52939 10389 90565077
Stomatitis 44.65 11.45 57 52924 274641 90300825
Bursitis 44.61 11.45 11 52970 131643 90443823
Hyponatraemia 44.42 11.45 175 52806 133363 90442103
Blood cholesterol increased 44.35 11.45 34 52947 207978 90367488
Musculoskeletal stiffness 43.73 11.45 66 52915 296466 90279000
Psoriasis 43.45 11.45 16 52965 147738 90427728
Vomiting 43.13 11.45 673 52308 787620 89787846
Pruritus 42.34 11.45 168 52813 541357 90034109
Lip dry 41.70 11.45 5 52976 100950 90474516
Swelling face 41.49 11.45 123 52858 81229 90494237
Febrile neutropenia 41.47 11.45 193 52788 158156 90417310
Hypokalaemia 40.56 11.45 168 52813 130948 90444518
Mobility decreased 39.23 11.45 266 52715 250468 90324998
Urinary retention 38.85 11.45 75 52906 37669 90537797
Obesity 37.37 11.45 8 52973 105499 90469967
Red blood cell sedimentation rate increased 36.97 11.45 3 52978 82592 90492874
Gait inability 36.58 11.45 20 52961 146436 90429030
Analgesic therapy 36.42 11.45 14 52967 658 90574808
Angioedema 35.89 11.45 101 52880 64775 90510691
Dehydration 35.79 11.45 215 52766 194232 90381234
Lower respiratory tract infection 35.79 11.45 57 52924 250602 90324864
Injury 35.23 11.45 38 52943 197311 90378155
Antacid therapy 34.86 11.45 14 52967 740 90574726
Appendicolith 34.73 11.45 14 52967 747 90574719
Completed suicide 34.53 11.45 21 52960 145037 90430429
Drug intolerance 34.24 11.45 140 52841 447451 90128015
Pneumococcal infection 34.18 11.45 16 52965 1229 90574237
Drug therapy 33.91 11.45 14 52967 795 90574671
Anticoagulant therapy 33.77 11.45 14 52967 803 90574663
Intestinal obstruction 33.69 11.45 70 52911 37061 90538405
Hypersensitivity 33.68 11.45 144 52837 454533 90120933
Arthritis 33.60 11.45 29 52952 167286 90408180
Dyspepsia 33.27 11.45 214 52767 197946 90377520
Hypercholesterolaemia 33.09 11.45 9 52972 100883 90474583
Peripheral venous disease 32.66 11.45 5 52976 83916 90491550
Blood test abnormal 32.59 11.45 50 52931 20902 90554564
Blood creatinine increased 32.21 11.45 131 52850 101255 90474211
Wound infection 32.17 11.45 11 52970 106391 90469075
Pyrexia 31.31 11.45 551 52430 659934 89915532
Lung disorder 31.30 11.45 25 52956 149858 90425608
Adverse event 30.86 11.45 15 52966 117403 90458063
Hypoaesthesia 30.28 11.45 89 52892 314121 90261345
Erythema 29.42 11.45 232 52749 229014 90346452
Pulmonary mass 29.40 11.45 57 52924 28715 90546751
Intentional product use issue 29.40 11.45 51 52930 216841 90358625
Mental status changes 29.20 11.45 74 52907 44605 90530861
Hip arthroplasty 28.63 11.45 5 52976 76203 90499263
Osteoarthritis 28.42 11.45 44 52937 195686 90379780
Therapy non-responder 28.30 11.45 23 52958 136681 90438785
Drug abuse 28.25 11.45 109 52872 82238 90493228
Hypertension 28.03 11.45 155 52826 457377 90118089
Road traffic accident 27.90 11.45 14 52967 107612 90467854
Pleural effusion 27.49 11.45 134 52847 111857 90463609
Lower limb fracture 27.10 11.45 8 52973 85005 90490461
Prescribed overdose 26.38 11.45 12 52969 97613 90477853
Blood phosphorus increased 26.02 11.45 21 52960 4297 90571169
Migraine 25.59 11.45 45 52936 190347 90385119
Injection site pain 25.26 11.45 39 52942 173660 90401806
Off label use 25.07 11.45 831 52150 1101421 89474045
Rales 24.94 11.45 38 52943 15789 90559677
Impaired gastric emptying 24.94 11.45 34 52947 12775 90562691
Colitis ischaemic 24.38 11.45 33 52948 12313 90563153
Musculoskeletal pain 24.38 11.45 39 52942 171212 90404254
Night sweats 23.87 11.45 24 52957 128742 90446724
Pleuritic pain 23.83 11.45 30 52951 10431 90565035
Aspiration 23.78 11.45 37 52944 15656 90559810
Urinary tract infection 23.66 11.45 278 52703 305354 90270112
Noninfectious peritonitis 23.43 11.45 7 52974 150 90575316
Interstitial lung disease 22.92 11.45 8 52973 76397 90499069
Pain in extremity 22.74 11.45 162 52819 450367 90125099
Death 22.72 11.45 384 52597 456167 90119299
Dry mouth 22.55 11.45 46 52935 184013 90391453
Sciatica 22.33 11.45 16 52965 101366 90474100
Hyperphosphataemia 22.26 11.45 18 52963 3693 90571773
Activated partial thromboplastin time prolonged 22.04 11.45 25 52956 7800 90567666
Hepatic cirrhosis 21.98 11.45 5 52976 63248 90512218
Visual impairment 21.98 11.45 27 52954 132338 90443128
Abortion spontaneous 21.55 11.45 3 52978 54053 90521413
Flatulence 21.52 11.45 63 52918 41304 90534162
Drug dose titration not performed 21.43 11.45 10 52971 762 90574704
Foreign body 21.43 11.45 15 52966 2479 90572987
Gastrooesophageal reflux disease 21.15 11.45 168 52813 166169 90409297
Taste disorder 21.12 11.45 5 52976 61541 90513925
Pelvic kidney 21.12 11.45 6 52975 107 90575359
Drug ineffective for unapproved indication 21.08 11.45 86 52895 66558 90508908
Gamma-glutamyltransferase increased 20.90 11.45 59 52922 37893 90537573
Paraesthesia 20.59 11.45 76 52905 250250 90325216
Adverse drug reaction 20.24 11.45 23 52958 116678 90458788
Hepatitis 20.22 11.45 8 52973 70731 90504735
Listless 20.00 11.45 16 52965 3233 90572233
Nail disorder 19.88 11.45 5 52976 59062 90516404
Loss of bladder sensation 19.67 11.45 5 52976 57 90575409
Abdominal distension 19.48 11.45 137 52844 130464 90445002
Epilepsy 19.42 11.45 12 52969 82194 90493272
Atonic urinary bladder 19.14 11.45 6 52975 152 90575314
Anal incontinence 18.89 11.45 34 52947 16196 90559270
Exostosis 18.87 11.45 4 52977 53130 90522336
Ascites 18.73 11.45 66 52915 47674 90527792
Therapeutic response decreased 18.69 11.45 15 52966 89714 90485752
Pain 18.65 11.45 735 52246 995606 89579860
Lung neoplasm 18.10 11.45 21 52960 6714 90568752
Hypophagia 18.00 11.45 54 52927 35883 90539583
Prescription drug used without a prescription 17.88 11.45 15 52966 3240 90572226
Liver disorder 17.85 11.45 27 52954 121242 90454224
C-reactive protein increased 17.74 11.45 51 52930 181338 90394128
Laryngitis 17.66 11.45 4 52977 50749 90524717
Prescribed underdose 17.65 11.45 11 52970 75008 90500458
Back injury 17.64 11.45 3 52978 46619 90528847
Onychomadesis 17.32 11.45 3 52978 45995 90529471
Dementia 17.16 11.45 41 52940 23820 90551646
Hydronephrosis 17.09 11.45 28 52953 12374 90563092
Oedema 17.01 11.45 60 52921 200235 90375231
Fatigue 16.95 11.45 530 52451 1153493 89421973
Leukocytosis 16.90 11.45 48 52933 30942 90544524
Body dysmorphic disorder 16.84 11.45 7 52974 404 90575062
Memory impairment 16.80 11.45 59 52922 197185 90378281
Reduced facial expression 16.63 11.45 13 52968 2540 90572926
Injection site erythema 16.45 11.45 20 52961 98482 90476984
Intracranial pressure increased 16.27 11.45 20 52961 6791 90568675
Pregnancy 16.19 11.45 8 52973 62039 90513427
Injection site reaction 16.12 11.45 18 52963 92062 90483404
Mutism 16.04 11.45 11 52970 1758 90573708
Female sexual arousal disorder 16.04 11.45 4 52977 42 90575424
Knee arthroplasty 16.00 11.45 15 52966 83167 90492299
Failure to thrive 15.88 11.45 22 52959 8389 90567077
Small intestinal obstruction 15.83 11.45 37 52944 21197 90554269
Sleep disorder 15.71 11.45 61 52920 197969 90377497
Malnutrition 15.69 11.45 34 52947 18524 90556942
Spleen atrophy 15.63 11.45 4 52977 47 90575419
Sepsis 15.46 11.45 167 52814 179647 90395819
Ear infection 15.38 11.45 11 52970 69764 90505702
Hyponatraemic encephalopathy 15.26 11.45 6 52975 300 90575166
Pseudohyponatraemia 14.98 11.45 4 52977 56 90575410
Proctalgia 14.82 11.45 21 52960 8177 90567289
Intestinal perforation 14.80 11.45 28 52953 13853 90561613
Diabetic ketosis 14.75 11.45 7 52974 554 90574912
Encephalopathy 14.74 11.45 60 52921 46384 90529082
Sputum discoloured 14.62 11.45 35 52946 20356 90555110
Anal sphincter atony 14.59 11.45 6 52975 337 90575129
Effusion 14.53 11.45 11 52970 2051 90573415
Subileus 14.49 11.45 14 52967 3630 90571836
Product quality issue 14.45 11.45 15 52966 79310 90496156
Pulmonary embolism 14.43 11.45 128 52853 130692 90444774
Neurogenic bladder 14.38 11.45 14 52967 3664 90571802
Contusion 14.34 11.45 87 52894 251129 90324337
Delayed haemolytic transfusion reaction 14.32 11.45 3 52978 13 90575453
Transaminases increased 14.23 11.45 51 52930 37141 90538325
International normalised ratio increased 14.13 11.45 60 52921 47256 90528210
Listeraemia 14.10 11.45 4 52977 71 90575395
Obstructive airways disorder 14.04 11.45 40 52941 25829 90549637
Cytokine release syndrome 13.98 11.45 42 52939 27931 90547535
Injection site swelling 13.77 11.45 9 52972 59830 90515636
Oesophageal hypomotility 13.66 11.45 5 52976 205 90575261
Oesophageal achalasia 13.59 11.45 7 52974 661 90574805
Urine flow decreased 13.44 11.45 6 52975 413 90575053
Gastritis 13.30 11.45 54 52927 41699 90533767
Infrapatellar fat pad inflammation 13.19 11.45 5 52976 226 90575240
Urinary tract infection staphylococcal 13.14 11.45 6 52975 435 90575031
Onychomycosis 12.90 11.45 3 52978 37373 90538093
Joint stiffness 12.87 11.45 16 52965 78026 90497440
Blood uric acid increased 12.86 11.45 19 52962 7685 90567781
Decubitus ulcer 12.81 11.45 24 52957 11789 90563677
Device expulsion 12.76 11.45 4 52977 40882 90534584
Unresponsive to stimuli 12.70 11.45 50 52931 38071 90537395
Aortic stenosis 12.61 11.45 17 52964 6319 90569147
Underdose 12.60 11.45 8 52973 54009 90521457
Sleep disorder therapy 12.59 11.45 6 52975 480 90574986
Petit mal epilepsy 12.56 11.45 15 52966 4943 90570523
Steatohepatitis 12.28 11.45 7 52974 809 90574657
Iron deficiency anaemia 12.27 11.45 36 52945 23626 90551840
Nasal herpes 12.20 11.45 7 52974 819 90574647
PCO2 abnormal 11.96 11.45 4 52977 125 90575341
Walking aid user 11.96 11.45 3 52978 35503 90539963
Drug reaction with eosinophilia and systemic symptoms 11.95 11.45 5 52976 42753 90532713
Torsade de pointes 11.92 11.45 27 52954 15155 90560311
Bladder disorder 11.82 11.45 22 52959 10750 90564716
Acquired diaphragmatic eventration 11.80 11.45 6 52975 552 90574914
Anticholinergic syndrome 11.79 11.45 11 52970 2732 90572734
Accidental exposure to product 11.77 11.45 5 52976 42361 90533105
Acute respiratory failure 11.73 11.45 53 52928 42865 90532601
Overflow diarrhoea 11.70 11.45 4 52977 134 90575332
Gastrointestinal motility disorder 11.60 11.45 16 52965 6075 90569391
Blister infected 11.55 11.45 7 52974 906 90574560
Neutrophil count increased 11.53 11.45 31 52950 19359 90556107

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 376.90 12.09 202 38594 13254 42569285
Appendicitis 314.01 12.09 209 38587 20404 42562135
Blood phosphorus increased 232.83 12.09 144 38652 12381 42570158
Cardiogenic shock 228.28 12.09 217 38579 35423 42547116
Ventricular fibrillation 221.24 12.09 198 38598 29925 42552614
Stress 206.40 12.09 227 38569 43985 42538554
Abdominal distension 205.34 12.09 288 38508 71447 42511092
Hyperphosphataemia 195.94 12.09 131 38665 12873 42569666
Ascites 187.20 12.09 244 38552 56434 42526105
Myasthenia gravis 183.79 12.09 137 38659 16000 42566539
Hyponatraemia 180.77 12.09 328 38468 101134 42481405
Sleep disorder therapy 166.80 12.09 94 38702 6800 42575739
Analgesic therapy 155.26 12.09 88 38708 6436 42576103
Neuralgia 145.19 12.09 146 38650 25501 42557038
Incorrect route of product administration 133.27 12.09 136 38660 24169 42558370
Drug therapy 130.49 12.09 78 38718 6302 42576237
Blood uric acid increased 129.84 12.09 110 38686 15437 42567102
Hypophosphataemia 129.27 12.09 125 38671 20820 42561719
Sepsis 118.09 12.09 424 38372 198910 42383629
Bacterial infection 117.85 12.09 136 38660 27743 42554796
Iron deficiency 115.10 12.09 89 38707 10972 42571567
General physical health deterioration 113.89 12.09 349 38447 150897 42431642
Activated partial thromboplastin time prolonged 113.69 12.09 103 38693 15800 42566739
Multiple organ dysfunction syndrome 111.59 12.09 262 38534 96773 42485766
Respiratory depression 109.71 12.09 109 38687 18759 42563780
Dry mouth 109.40 12.09 157 38639 39722 42542817
Cerebral hypoperfusion 106.87 12.09 39 38757 1004 42581535
Epidural lipomatosis 105.74 12.09 45 38751 1755 42580784
Antacid therapy 105.21 12.09 61 38735 4656 42577883
Anticoagulant therapy 99.44 12.09 58 38738 4477 42578062
Blood cholesterol increased 99.11 12.09 122 38674 26619 42555920
Victim of child abuse 98.32 12.09 38 38758 1151 42581388
Intentional product misuse 93.90 12.09 187 38609 61713 42520826
Juvenile idiopathic arthritis 89.29 12.09 45 38751 2594 42579945
End stage renal disease 85.97 12.09 90 38706 16468 42566071
Ulcer 82.94 12.09 88 38708 16353 42566186
Sleep disorder 82.38 12.09 153 38643 47942 42534597
IVth nerve paralysis 79.27 12.09 27 38769 564 42581975
Bronchopulmonary aspergillosis allergic 78.23 12.09 50 38746 4548 42577991
Somnolence 77.43 12.09 293 38503 140812 42441727
Abdominal pain 76.86 12.09 360 38436 190111 42392428
Aortic stenosis 75.33 12.09 63 38733 8682 42573857
Thrombosis 74.41 12.09 181 38615 68330 42514209
Blood calcium increased 73.02 12.09 61 38735 8393 42574146
Congenital hiatus hernia 67.13 12.09 51 38745 6123 42576416
Constipation 66.36 12.09 308 38488 161983 42420556
Chronic obstructive pulmonary disease 65.63 12.09 164 38632 62950 42519589
Micturition urgency 62.35 12.09 65 38731 11833 42570706
Drug dependence 60.76 12.09 101 38695 28993 42553546
Completed suicide 60.72 12.09 8 38788 96457 42486082
Product prescribing error 59.08 12.09 94 38702 26018 42556521
Vomiting 59.02 12.09 458 38338 289265 42293274
Swelling 57.46 12.09 143 38653 54742 42527797
Gout 56.73 12.09 96 38700 27959 42554580
Troponin increased 56.64 12.09 78 38718 18984 42563555
Hyperlipidaemia 56.50 12.09 83 38713 21433 42561106
Total lung capacity decreased 56.26 12.09 37 38759 3533 42579006
Diabetes mellitus 56.14 12.09 150 38646 59937 42522602
Pulmonary embolism 55.66 12.09 236 38560 119376 42463163
Drug ineffective 54.42 12.09 344 38452 629853 41952686
Respiratory symptom 51.73 12.09 57 38739 11049 42571490
Bacteroides infection 51.27 12.09 31 38765 2556 42579983
Blood test abnormal 51.26 12.09 61 38735 12845 42569694
IgA nephropathy 51.09 12.09 30 38766 2344 42580195
Pleuritic pain 48.93 12.09 45 38751 7032 42575507
Aspiration 42.69 12.09 66 38730 17820 42564719
Diarrhoea 42.05 12.09 247 38549 460602 42121937
Brain scan abnormal 41.54 12.09 21 38775 1218 42581321
Cerebral artery thrombosis 41.38 12.09 21 38775 1228 42581311
Binocular eye movement disorder 41.21 12.09 14 38782 290 42582249
Lung opacity 40.13 12.09 37 38759 5800 42576739
Interstitial lung disease 38.06 12.09 12 38784 78450 42504089
Toxicity to various agents 37.47 12.09 97 38699 229039 42353500
Arthralgia 36.62 12.09 83 38713 205155 42377384
On and off phenomenon 34.12 12.09 27 38769 3440 42579099
Cerebellar stroke 31.16 12.09 14 38782 623 42581916
Antineutrophil cytoplasmic antibody positive 30.65 12.09 28 38768 4337 42578202
Treatment failure 29.63 12.09 10 38786 62614 42519925
Injection site pain 29.57 12.09 8 38788 57790 42524749
Conjunctivitis allergic 28.68 12.09 31 38765 5880 42576659
Drug interaction 28.23 12.09 136 38660 266863 42315676
Drug intolerance 28.06 12.09 146 38650 80278 42502261
Joint injury 28.06 12.09 49 38747 14627 42567912
Mycotic allergy 27.95 12.09 28 38768 4863 42577676
Capillaritis 27.81 12.09 20 38776 2208 42580331
Obesity 27.71 12.09 52 38744 16407 42566132
Intestinal pseudo-obstruction 27.59 12.09 20 38776 2235 42580304
Mite allergy 27.21 12.09 28 38768 5018 42577521
Anaemia 27.13 12.09 381 38415 279897 42302642
Total lung capacity abnormal 26.43 12.09 26 38770 4417 42578122
Dust allergy 25.93 12.09 28 38768 5304 42577235
Drug hypersensitivity 25.91 12.09 167 38629 99222 42483317
Nausea 25.38 12.09 504 38292 396295 42186244
Full blood count abnormal 25.32 12.09 72 38724 29804 42552735
Spirometry abnormal 24.99 12.09 27 38769 5119 42577420
Intentional overdose 24.72 12.09 8 38788 51448 42531091
Tenderness 24.38 12.09 35 38761 8848 42573691
Psoriasis 24.35 12.09 7 38789 48597 42533942
Benign prostatic hyperplasia 24.32 12.09 57 38739 20995 42561544
Foetal disorder 24.18 12.09 14 38782 1065 42581474
Neuritis 24.04 12.09 29 38767 6191 42576348
Breath sounds abnormal 23.93 12.09 41 38755 12052 42570487
Pulmonary vasculitis 23.87 12.09 29 38767 6237 42576302
Child abuse 23.87 12.09 13 38783 879 42581660
Urinary tract infection 23.58 12.09 163 38633 99121 42483418
Hypoxia 23.19 12.09 125 38671 69661 42512878
Overdose 22.72 12.09 38 38758 105226 42477313
Nasopharyngitis 22.45 12.09 26 38770 83970 42498569
Areflexia 22.45 12.09 22 38774 3721 42578818
Urosepsis 22.29 12.09 45 38751 14975 42567564
Rash 21.34 12.09 156 38640 276798 42305741
Neutropenia neonatal 20.79 12.09 12 38784 908 42581631
Suicide attempt 20.72 12.09 8 38788 46092 42536447
Pruritus 20.61 12.09 95 38701 188676 42393863
Mixed dementia 20.00 12.09 8 38788 266 42582273
Normochromic normocytic anaemia 19.72 12.09 32 38764 8999 42573540
Forced expiratory volume decreased 19.40 12.09 29 38767 7601 42574938
Feeling cold 18.23 12.09 38 38758 12935 42569604
Myelosuppression 18.22 12.09 7 38789 40454 42542085
Eosinophilic granulomatosis with polyangiitis 18.04 12.09 30 38766 8608 42573931
Renal impairment 17.73 12.09 47 38749 110181 42472358
Sitting disability 17.60 12.09 7 38789 229 42582310
Musculoskeletal stiffness 17.54 12.09 101 38695 57664 42524875
Speech disorder 17.21 12.09 62 38734 29059 42553480
Renal failure 16.48 12.09 71 38725 143655 42438884
Disease progression 16.45 12.09 71 38725 143585 42438954
Paraesthesia 16.33 12.09 26 38770 73433 42509106
Neurological symptom 16.12 12.09 31 38765 9960 42572579
Condition aggravated 15.88 12.09 329 38467 260425 42322114
Erythema 15.59 12.09 49 38747 108744 42473795
Small intestinal obstruction 15.33 12.09 42 38754 17019 42565520
Hyporesponsive to stimuli 15.13 12.09 12 38784 1534 42581005
Insomnia 14.44 12.09 57 38739 118196 42464343
Hypercholesterolaemia 13.99 12.09 34 38762 12815 42569724
Jaundice 13.97 12.09 7 38789 34582 42547957
Wrong technique in product usage process 13.95 12.09 11 38785 42624 42539915
Arteriosclerosis 13.95 12.09 42 38754 17947 42564592
Hypersensitivity 13.94 12.09 28 38768 72342 42510197
Cytomegalovirus infection 13.88 12.09 6 38790 32300 42550239
Drug ineffective for unapproved indication 13.78 12.09 13 38783 46150 42536389
Ischaemic stroke 13.70 12.09 48 38748 22185 42560354
Psoriatic arthropathy 13.66 12.09 3 38793 24964 42557575
Pulmonary fibrosis 13.45 12.09 54 38742 26627 42555912
Faecaloma 13.40 12.09 22 38774 6248 42576291
Joint swelling 13.37 12.09 26 38770 67996 42514543
Weight increased 13.21 12.09 52 38744 107931 42474608
Myocardial infarction 13.17 12.09 63 38733 123946 42458593
Cardiovascular disorder 13.12 12.09 34 38762 13331 42569208
Neurogenic bladder 13.03 12.09 13 38783 2247 42580292
Malaise 12.95 12.09 127 38669 212029 42370510
Dry skin 12.87 12.09 15 38781 48323 42534216
Pulmonary alveolar haemorrhage 12.84 12.09 36 38760 14780 42567759
Chest discomfort 12.78 12.09 24 38772 63592 42518947
Therapy non-responder 12.72 12.09 18 38778 53341 42529198
Hepatic function abnormal 12.69 12.09 17 38779 51550 42530989
Rheumatoid arthritis 12.61 12.09 12 38784 42428 42540111
Medical device site dryness 12.33 12.09 3 38793 17 42582522
Haemoptysis 12.28 12.09 78 38718 46089 42536450
Foetal exposure during pregnancy 12.26 12.09 15 38781 47296 42535243
Transcription medication error 12.23 12.09 6 38790 326 42582213
Hypogonadism 12.22 12.09 13 38783 2421 42580118
Frustration tolerance decreased 12.18 12.09 15 38781 3271 42579268
Hemiplegia 12.17 12.09 24 38772 7855 42574684

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 444.79 11.19 216 82492 14039 110492552
Sedation complication 409.88 11.19 228 82480 19627 110486964
Creatinine renal clearance decreased 400.48 11.19 232 82476 21583 110485008
Schizophrenia 366.20 11.19 219 82489 21607 110484984
Hypomania 343.71 11.19 163 82545 10047 110496544
Chronic sinusitis 343.09 11.19 221 82487 24863 110481728
Appendicitis 334.18 11.19 228 82480 28236 110478355
Blood calcium decreased 333.07 11.19 249 82459 35596 110470995
Constipation 330.15 11.19 786 81922 357000 110149591
Orthostatic hypotension 315.77 11.19 314 82394 65935 110440656
Vaginal flatulence 293.96 11.19 155 82553 11989 110494602
Macular degeneration 291.72 11.19 189 82519 21470 110485121
Jaundice cholestatic 283.21 11.19 161 82547 14447 110492144
Cognitive disorder 274.63 11.19 333 82375 87178 110419413
Blood phosphorus increased 274.23 11.19 164 82544 16176 110490415
Female genital tract fistula 269.99 11.19 163 82545 16356 110490235
Proctitis 258.67 11.19 160 82548 16767 110489824
Sedation 253.37 11.19 286 82422 69397 110437194
Vaginal discharge 252.88 11.19 161 82547 17747 110488844
Radiculopathy 246.43 11.19 163 82545 19173 110487418
Ventricular fibrillation 244.93 11.19 221 82487 41092 110465499
Hyperphosphataemia 238.12 11.19 150 82558 16231 110490360
Paraesthesia oral 237.73 11.19 199 82509 33472 110473119
Balance disorder 228.30 11.19 353 82355 116207 110390384
Cardiogenic shock 219.90 11.19 242 82466 57096 110449495
Hyponatraemia 217.85 11.19 494 82214 217159 110289432
Ascites 216.23 11.19 305 82403 92503 110414088
Analgesic therapy 205.28 11.19 103 82605 7181 110499410
Chronic obstructive pulmonary disease 201.86 11.19 322 82386 108836 110397755
Cholelithiasis 200.03 11.19 242 82466 63180 110443411
Procedural pain 198.62 11.19 184 82524 35381 110471210
Sleep disorder therapy 197.00 11.19 101 82607 7370 110499221
Total lung capacity increased 195.00 11.19 89 82619 5023 110501568
Myasthenia gravis 192.20 11.19 146 82562 21365 110485226
Asthma-chronic obstructive pulmonary disease overlap syndrome 176.70 11.19 89 82619 6255 110500336
Drug therapy 176.29 11.19 93 82615 7198 110499393
Abdominal pain 174.83 11.19 803 81905 512186 109994405
Abdominal distension 166.96 11.19 390 82318 174713 110331878
Depressed level of consciousness 159.91 11.19 295 82413 111983 110394608
Blood uric acid increased 155.62 11.19 129 82579 21400 110485191
Psychotic disorder 155.17 11.19 191 82517 50746 110455845
Oral candidiasis 154.71 11.19 179 82529 44581 110462010
Joint swelling 151.27 11.19 71 82637 442774 110063817
Rheumatoid arthritis 151.26 11.19 22 82686 299591 110207000
Antacid therapy 147.09 11.19 75 82633 5409 110501182
Glossodynia 143.68 11.19 5 82703 221999 110284592
Bronchiectasis 143.34 11.19 156 82552 36337 110470254
Activated partial thromboplastin time prolonged 143.20 11.19 125 82583 22243 110484348
Sepsis 140.56 11.19 550 82158 326796 110179795
Anticoagulant therapy 139.98 11.19 72 82636 5289 110501302
Bronchopulmonary aspergillosis allergic 139.90 11.19 84 82624 8342 110498249
Hypophosphataemia 139.41 11.19 147 82561 33035 110473556
Arthropathy 138.63 11.19 24 82684 287498 110219093
Pemphigus 138.28 11.19 5 82703 214565 110292026
Arthralgia 134.35 11.19 236 82472 779396 109727195
Stress 131.81 11.19 262 82446 105086 110401505
Treatment failure 131.79 11.19 24 82684 277210 110229381
Maternal exposure during pregnancy 130.33 11.19 18 82690 254865 110251726
Blood calcium increased 128.11 11.19 107 82601 17933 110488658
Alopecia 123.73 11.19 59 82649 364694 110141897
Total lung capacity decreased 123.53 11.19 73 82635 7041 110499550
Nasal polyps 123.26 11.19 92 82616 13108 110493483
Systemic lupus erythematosus 123.11 11.19 21 82687 254317 110252274
Blood bilirubin increased 121.48 11.19 210 82498 75762 110430829
Sarcoidosis 120.44 11.19 89 82619 12490 110494101
Bacterial infection 118.79 11.19 159 82549 45877 110460714
Duodenal ulcer perforation 118.63 11.19 3 82705 177697 110328894
Pericarditis 118.07 11.19 13 82695 219101 110287490
Helicobacter infection 118.02 11.19 4 82704 181873 110324718
Cardiac murmur 117.79 11.19 117 82591 24511 110482080
Anaemia 116.80 11.19 754 81954 546332 109960259
Frequent bowel movements 113.71 11.19 197 82511 71193 110435398
Psoriatic arthropathy 113.12 11.19 9 82699 196752 110309839
Contraindicated product administered 112.73 11.19 24 82684 248243 110258348
Wound 112.06 11.19 20 82688 234417 110272174
Hypotension 111.21 11.19 721 81987 523128 109983463
Colitis 111.01 11.19 240 82468 102083 110404508
Iron deficiency 109.81 11.19 99 82609 18377 110488214
Neuralgia 109.45 11.19 157 82551 48321 110458270
End stage renal disease 108.26 11.19 105 82603 21368 110485223
Epidural lipomatosis 108.26 11.19 45 82663 2022 110504569
Nausea 107.87 11.19 1402 81306 1234288 109272303
Rhinitis allergic 106.45 11.19 96 82612 17826 110488765
Victim of child abuse 104.91 11.19 38 82670 1173 110505418
Hepatotoxicity 103.66 11.19 177 82531 63223 110443368
Fibromyalgia 103.56 11.19 6 82702 170903 110335688
Rash 102.64 11.19 296 82412 820668 109685923
Completed suicide 101.12 11.19 28 82680 242353 110264238
Therapeutic product effect decreased 98.66 11.19 30 82678 244286 110262305
Multiple organ dysfunction syndrome 96.73 11.19 291 82417 151419 110355172
Nasopharyngitis 94.85 11.19 93 82615 394268 110112323
Colitis ulcerative 93.88 11.19 190 82518 77173 110429418
Aortic stenosis 93.86 11.19 78 82630 12981 110493610
Folliculitis 92.76 11.19 9 82699 167644 110338947
Lung opacity 90.90 11.19 73 82635 11579 110495012
Blood test abnormal 90.08 11.19 109 82599 28445 110478146
Respiratory depression 87.93 11.19 114 82594 31887 110474704
Haematochezia 87.68 11.19 236 82472 115288 110391303
Intestinal pseudo-obstruction 87.41 11.19 45 82663 3311 110503280
Fall 86.39 11.19 757 81951 602725 109903866
Exposure during pregnancy 85.15 11.19 12 82696 167412 110339179
Impaired healing 83.41 11.19 22 82686 196695 110309896
Irritable bowel syndrome 82.98 11.19 12 82696 164203 110342388
Pulmonary embolism 82.93 11.19 349 82359 214125 110292466
Rectal haemorrhage 82.26 11.19 236 82472 119597 110386994
IVth nerve paralysis 81.59 11.19 27 82681 632 110505959
Vomiting 80.82 11.19 1037 81671 909638 109596953
Type 2 diabetes mellitus 80.72 11.19 17 82691 177215 110329376
Weight increased 80.65 11.19 118 82590 419526 110087065
Pleuritic pain 79.64 11.19 78 82630 16062 110490529
Sinusitis 78.47 11.19 64 82644 296624 110209967
Drug ineffective 78.05 11.19 745 81963 1519795 108986796
Urticaria 78.04 11.19 74 82634 318783 110187808
Congenital hiatus hernia 77.90 11.19 52 82656 6207 110500384
Peripheral swelling 76.29 11.19 115 82593 403919 110102672
Creatinine renal clearance increased 75.81 11.19 42 82666 3583 110503008
Aspiration 73.53 11.19 102 82606 30431 110476160
Thrombosis 72.65 11.19 212 82496 108450 110398141
Intentional product misuse 71.97 11.19 241 82467 132663 110373928
Incorrect route of product administration 71.47 11.19 152 82556 63909 110442682
Multiple drug therapy 70.72 11.19 54 82654 7960 110498631
Inflammation 70.65 11.19 28 82680 193210 110313381
Renal function test abnormal 69.69 11.19 56 82652 8890 110497701
Juvenile idiopathic arthritis 67.85 11.19 47 82661 5960 110500631
Gout 67.73 11.19 108 82600 36458 110470133
Bursitis 66.80 11.19 9 82699 129909 110376682
Hypoxia 65.87 11.19 230 82478 129285 110377306
Troponin increased 65.14 11.19 95 82613 29671 110476920
Pruritus 63.91 11.19 222 82486 581338 109925253
Ill-defined disorder 63.78 11.19 19 82689 156834 110349757
Swollen tongue 62.52 11.19 139 82569 60223 110446368
Hyperlipidaemia 62.48 11.19 103 82605 35745 110470846
Lip dry 62.23 11.19 3 82705 100080 110406511
Abdominal discomfort 61.73 11.19 126 82582 393732 110112859
Facet joint syndrome 59.89 11.19 3 82705 96825 110409766
Joint range of motion decreased 59.06 11.19 10 82698 121822 110384769
Stomatitis 57.99 11.19 70 82638 270172 110236419
Blister 56.52 11.19 52 82656 227324 110279267
Liver injury 56.30 11.19 21 82687 150392 110356199
Drug dependence 55.00 11.19 118 82590 49902 110456689
Infection 54.14 11.19 119 82589 362081 110144510
Bacteroides infection 53.44 11.19 31 82677 2888 110503703
Faecaloma 52.14 11.19 60 82648 14848 110491743
Product prescribing error 51.81 11.19 117 82591 51214 110455377
Interstitial lung disease 51.24 11.19 20 82688 139314 110367277
Somnolence 50.46 11.19 388 82320 297061 110209530
Diabetes mellitus 50.11 11.19 176 82532 99205 110407386
Psoriasis 50.00 11.19 21 82687 139972 110366619
General physical health deterioration 49.56 11.19 511 82197 424784 110081807
IgA nephropathy 48.49 11.19 30 82678 3143 110503448
Peripheral venous disease 47.91 11.19 4 82704 84113 110422478
Ulcer 47.74 11.19 102 82606 43014 110463577
Respiratory symptom 47.05 11.19 57 82651 14888 110491703
Injection site pain 46.26 11.19 39 82669 177883 110328708
Lung neoplasm malignant 45.75 11.19 87 82621 33755 110472836
Urinary retention 45.65 11.19 135 82573 69548 110437043
Musculoskeletal pain 45.31 11.19 42 82666 182981 110323610
Paraesthesia 44.56 11.19 87 82621 276434 110230157
Injury 43.51 11.19 41 82667 177224 110329367
Myelosuppression 43.05 11.19 9 82699 94331 110412260
Therapy non-responder 42.74 11.19 33 82675 157274 110349317
Intentional product use issue 42.60 11.19 75 82633 247831 110258760
Hypersensitivity 42.49 11.19 157 82551 403841 110102750
Cerebral artery thrombosis 42.39 11.19 22 82686 1646 110504945
Brain scan abnormal 40.73 11.19 21 82687 1550 110505041
Diarrhoea 40.31 11.19 605 82103 1138900 109367691
Discomfort 39.63 11.19 62 82646 214645 110291946
Osteoarthritis 39.49 11.19 47 82661 182576 110324015
Red blood cell sedimentation rate increased 38.91 11.19 6 82702 78296 110428295
Oedema peripheral 38.79 11.19 396 82312 328264 110178327
Micturition urgency 38.47 11.19 59 82649 19261 110487330
Hypoaesthesia 37.90 11.19 115 82593 314108 110192483
Blood creatinine increased 37.63 11.19 250 82458 182639 110323952
Arthritis 37.46 11.19 42 82666 167544 110339047
Febrile neutropenia 37.06 11.19 381 82327 316386 110190205
Autoimmune disorder 34.97 11.19 4 82704 65479 110441112
Gait inability 34.11 11.19 31 82677 136345 110370246
Benign prostatic hyperplasia 33.96 11.19 54 82654 18180 110488411
Antineutrophil cytoplasmic antibody positive 33.77 11.19 29 82679 5047 110501544
Wound infection 33.61 11.19 15 82693 96450 110410141
Conjunctivitis allergic 33.27 11.19 33 82675 6898 110499693
Hypokalaemia 33.18 11.19 242 82466 182206 110324385
Night sweats 32.86 11.19 31 82677 133952 110372639
Road traffic accident 32.54 11.19 20 82688 107378 110399213
Urinary tract infection 32.44 11.19 380 82328 325902 110180689
Mobility decreased 32.40 11.19 295 82413 237127 110269464
Nail disorder 32.33 11.19 3 82705 57932 110448659
Pneumonia 32.30 11.19 871 81837 875843 109630748
Colitis ischaemic 32.28 11.19 52 82656 17698 110488893
Therapeutic response decreased 32.09 11.19 16 82692 96483 110410108
Pleural effusion 31.34 11.19 234 82474 177475 110329116
Epilepsy 31.29 11.19 18 82690 100191 110406400
Sciatica 31.21 11.19 15 82693 92384 110414207
Injection site reaction 30.79 11.19 14 82694 89056 110417535
Injection site erythema 30.74 11.19 16 82692 94160 110412431
Dysphonia 30.44 11.19 125 82583 75804 110430787
Total lung capacity abnormal 30.11 11.19 26 82682 4557 110502034
Small intestinal obstruction 29.84 11.19 71 82637 32142 110474449
Obstructive airways disorder 29.84 11.19 89 82619 46060 110460531
Capillaritis 29.72 11.19 20 82688 2419 110504172
Pulmonary mass 29.09 11.19 77 82631 37224 110469367
Visual impairment 28.63 11.19 35 82673 134393 110372198
Mite allergy 28.55 11.19 28 82680 5775 110500816
Migraine 28.52 11.19 53 82655 171599 110334992
Neuritis 27.96 11.19 31 82677 7368 110499223
Mycotic allergy 27.94 11.19 28 82680 5926 110500665
Spirometry abnormal 27.93 11.19 27 82681 5470 110501121
Dust allergy 27.75 11.19 28 82680 5973 110500618
Pulmonary vasculitis 27.44 11.19 29 82679 6531 110500060
Lower limb fracture 27.39 11.19 11 82697 75337 110431254
Prescribed overdose 26.96 11.19 16 82692 87565 110419026
Adverse event 26.89 11.19 25 82683 108784 110397807
C-reactive protein increased 26.81 11.19 79 82629 217840 110288751
Child abuse 26.32 11.19 13 82695 876 110505715
Rales 25.65 11.19 57 82651 24682 110481909
Therapeutic product effect incomplete 25.59 11.19 268 82440 223537 110283054
Haemoptysis 25.16 11.19 113 82595 71241 110435350
Pneumococcal infection 24.80 11.19 16 82692 1803 110504788
Gastrointestinal disorder 24.78 11.19 95 82613 241857 110264734
Memory impairment 24.52 11.19 71 82637 196873 110309718
Bone erosion 24.34 11.19 3 82705 46368 110460223
Pain in extremity 23.41 11.19 242 82466 486876 110019715
Normochromic normocytic anaemia 23.40 11.19 38 82670 13019 110493572
Insomnia 23.19 11.19 166 82542 360424 110146167
Injection site pruritus 23.16 11.19 5 82703 51253 110455338
Taste disorder 23.04 11.19 10 82698 65377 110441214
Drug-induced liver injury 22.80 11.19 34 82674 120033 110386558
Adjustment disorder with depressed mood 22.65 11.19 3 82705 43880 110462711
Injection site swelling 22.50 11.19 9 82699 61781 110444810
Hip arthroplasty 22.25 11.19 7 82701 55806 110450785
Sputum discoloured 22.11 11.19 58 82650 27887 110478704
Laryngitis 21.65 11.19 3 82705 42408 110464183
Onychomadesis 21.58 11.19 4 82704 45659 110460932
Dyspepsia 21.51 11.19 228 82480 190737 110315854
Hepatic cirrhosis 21.32 11.19 12 82696 67614 110438977
Transaminases increased 21.32 11.19 99 82609 63291 110443300
Contusion 21.18 11.19 96 82612 233265 110273326
Hypogonadism 21.12 11.19 15 82693 1979 110504612
Mixed dementia 21 11.19 8 82700 285 110506306
Dry skin 20.91 11.19 30 82678 107623 110398968
Ischaemic stroke 20.72 11.19 73 82635 41190 110465401
Back injury 20.66 11.19 5 82703 47394 110459197
Noninfectious peritonitis 20.54 11.19 8 82700 303 110506288
Neurogenic bladder 20.44 11.19 22 82686 5057 110501534
Muscle spasms 20.44 11.19 123 82585 278034 110228557
Osteoporosis 20.41 11.19 21 82687 87131 110419460
Rash pruritic 20.39 11.19 26 82682 98043 110408548
Breath sounds abnormal 20.38 11.19 53 82655 25351 110481240
Decubitus ulcer 20.02 11.19 43 82665 18193 110488398
Product quality issue 20.01 11.19 17 82691 77282 110429309
Swelling face 19.46 11.19 127 82581 92194 110414397
Dizziness 19.05 11.19 388 82320 697805 109808786
Onychomycosis 19.03 11.19 3 82705 38528 110468063
Dehydration 18.94 11.19 304 82404 279207 110227384
Pain 18.93 11.19 884 81824 954071 109552520
Cytokine release syndrome 18.85 11.19 103 82605 70203 110436388
Fatigue 18.74 11.19 732 81976 1215226 109291365
Mental status changes 18.74 11.19 109 82599 76013 110430578
Death 18.68 11.19 668 82040 698201 109808390
Liver disorder 18.65 11.19 50 82658 142193 110364398
Intentional overdose 18.59 11.19 45 82663 132456 110374135
Weight decreased 18.33 11.19 469 82239 467588 110039003
Pyrexia 18.12 11.19 833 81875 897432 109609159
Plasma cell myeloma 18.10 11.19 94 82614 62842 110443749
Flatulence 17.95 11.19 82 82626 52067 110454524
Eosinophilic granulomatosis with polyangiitis 17.68 11.19 30 82678 10656 110495935
Throat irritation 17.62 11.19 9 82699 53543 110453048
Atonic urinary bladder 17.39 11.19 6 82702 160 110506431
Excessive eye blinking 17.38 11.19 13 82695 1857 110504734
Arteriosclerosis 17.20 11.19 49 82659 24718 110481873
Intestinal obstruction 17.08 11.19 82 82626 53145 110453446
Joint injury 16.95 11.19 67 82641 39927 110466664
Urosepsis 16.92 11.19 56 82652 30619 110475972
Areflexia 16.88 11.19 23 82685 6746 110499845
Flushing 16.82 11.19 33 82675 104703 110401888
Unresponsive to stimuli 16.80 11.19 93 82615 63697 110442894
Leukocytosis 16.61 11.19 82 82626 53746 110452845
Impaired gastric emptying 16.57 11.19 33 82675 13242 110493349
Off label use 16.44 11.19 1318 81390 1498867 109007724
Wrong technique in product usage process 16.32 11.19 25 82683 87323 110419268
Drug eruption 16.24 11.19 10 82698 53649 110452942
Failure to thrive 16.06 11.19 33 82675 13541 110493050
Ear infection 15.99 11.19 14 82694 62718 110443873
Loss of bladder sensation 15.94 11.19 5 82703 98 110506493
Oedema 15.87 11.19 92 82616 209884 110296707
Foreign body 15.77 11.19 15 82693 2980 110503611
Hospice care 15.56 11.19 31 82677 12442 110494149
Chest discomfort 15.49 11.19 72 82636 173776 110332815
Malnutrition 15.23 11.19 50 82658 27229 110479362
Renal impairment 15.10 11.19 81 82627 188364 110318227
Knee arthroplasty 14.81 11.19 16 82692 64932 110441659
Body dysmorphic disorder 14.81 11.19 7 82701 428 110506163
Hypertension 14.64 11.19 281 82427 509803 109996788
Gastrooesophageal reflux disease 14.63 11.19 202 82506 179774 110326817
Product use issue 14.49 11.19 156 82552 311539 110195052
Haemophagocytic lymphohistiocytosis 14.42 11.19 3 82705 31556 110475035
Feeling hot 14.37 11.19 29 82679 91077 110415514
Dementia 14.19 11.19 54 82654 31619 110474972
Gastrointestinal motility disorder 14.18 11.19 22 82686 7254 110499337
Sitting disability 14.17 11.19 7 82701 472 110506119
On and off phenomenon 14.13 11.19 17 82691 4407 110502184
Device expulsion 13.98 11.19 3 82705 30888 110475703
Hyponatraemic seizure 13.93 11.19 8 82700 731 110505860
Adverse drug reaction 13.92 11.19 37 82671 105522 110401069
Respiratory disorder 13.76 11.19 20 82688 71362 110435229
Drug dose titration not performed 13.62 11.19 9 82699 1056 110505535
Hepatic function abnormal 13.60 11.19 29 82679 89266 110417325
Depression 13.50 11.19 162 82546 317173 110189418
Spleen atrophy 13.40 11.19 4 82704 66 110506525
Forced expiratory volume decreased 13.26 11.19 30 82678 13146 110493445
Hepatitis 13.10 11.19 30 82678 90024 110416567
Neurological symptom 12.97 11.19 33 82675 15575 110491016
Joint stiffness 12.80 11.19 19 82689 67224 110439367
Myocardial infarction 12.55 11.19 88 82620 191995 110314596
Lung neoplasm 12.48 11.19 22 82686 8054 110498537
Listeraemia 12.41 11.19 4 82704 86 110506505
Hyponatraemic encephalopathy 12.32 11.19 6 82702 392 110506199
Listless 12.27 11.19 16 82692 4499 110502092
Transcription medication error 12.09 11.19 7 82701 650 110505941
Delayed haemolytic transfusion reaction 12.02 11.19 3 82705 24 110506567
Immune effector cell-associated neurotoxicity syndrome 12.02 11.19 31 82677 14751 110491840
Infrapatellar fat pad inflammation 12.00 11.19 5 82703 226 110506365
Premature delivery 11.93 11.19 4 82704 30628 110475963
Bladder disorder 11.93 11.19 26 82682 11111 110495480
Perichondritis 11.80 11.19 6 82702 430 110506161
Deep vein thrombosis 11.78 11.19 158 82550 139729 110366862
Bronchitis 11.76 11.19 69 82639 156963 110349628
Full blood count abnormal 11.75 11.19 77 82631 55975 110450616
Reduced facial expression 11.62 11.19 14 82694 3637 110502954
Oesophageal achalasia 11.56 11.19 8 82700 1013 110505578
Herpes zoster 11.45 11.19 42 82666 108337 110398254
Disease progression 11.39 11.19 122 82586 243912 110262679
Atelectasis 11.38 11.19 56 82652 36656 110469935
Pulmonary alveolar haemorrhage 11.31 11.19 37 82671 20113 110486478
Injection site bruising 11.28 11.19 13 82695 51250 110455341
Psychomotor disadaptation syndrome 11.28 11.19 4 82704 116 110506475
Tremor 11.20 11.19 213 82495 202019 110304572

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A06AB02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Contact laxatives
ATC A06AB52 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Contact laxatives
ATC A06AG02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Enemas
FDA PE N0000009371 Increased Large Intestinal Motility
FDA PE N0000009871 Stimulation Large Intestine Fluid/Electrolyte Secretion
CHEBI has role CHEBI:50503 laxative
MeSH PA D002400 Cathartics
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054368 Laxatives
FDA EPC N0000175812 Stimulant Laxative

Related Drugs by ATC class:

A06AB Contact laxatives 6 drugs
bisoxatincastor oildantronoxyphenisatinephenolphthaleinsodium picosulfate
A06AG Enemas 5 drugs
dantrondocusate sodiumglycerolsodium phosphatesorbitol

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089
Incomplete passage of stool indication 249515001
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Rectal hemorrhage contraindication 12063002
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Acute vomiting contraindication 23971007
Complete atrioventricular block contraindication 27885002
Toxic megacolon contraindication 28536002 DOID:1770
Anal fissure contraindication 30037006
Gastrointestinal ulcer contraindication 40845000
Toxic colitis contraindication 42359007
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Gastrointestinal perforation contraindication 51875005
Chronic ulcerative proctitis contraindication 52231000
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Incontinence of feces contraindication 72042002
Appendicitis contraindication 74400008 DOID:8337
Hyperchloremia contraindication 74450001
Third degree burn injury contraindication 80247002
Intestinal obstruction contraindication 81060008 DOID:8437
Oliguria contraindication 83128009
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Gastrointestinal obstruction contraindication 126765001
Seizure disorder contraindication 128613002
Hyporeninemic hypoaldosteronism contraindication 236464008
Edema contraindication 267038008
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Gastric retention contraindication 307227006
At risk for aspiration contraindication 371736008
Severe dehydration contraindication 450316000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent dopamine transporter Transporter Ki 5.76 DRUG MATRIX
Kappa-type opioid receptor GPCR Ki 6.01 DRUG MATRIX
Cytochrome P450 2C9 Enzyme IC50 5 DRUG MATRIX

External reference:

IDSource
4018526 VUID
N0000146848 NUI
D00245 KEGG_DRUG
151672 RXNORM
C0005632 UMLSCUI
CHEBI:3125 CHEBI
CHEMBL942 ChEMBL_ID
DB09020 DRUGBANK_ID
D001726 MESH_DESCRIPTOR_UI
2391 PUBCHEM_CID
824 INN_ID
10X0709Y6I UNII
4286 MMSL
4855 MMSL
d01015 MMSL
13565005 SNOMEDCT_US
387075009 SNOMEDCT_US
4018526 VANDF
001172 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fleet HUMAN OTC DRUG LABEL 1 0132-0401 TABLET, COATED 5 mg ORAL OTC Monograph Drug 15 sections
Fleet HUMAN OTC DRUG LABEL 1 0132-0703 ENEMA 10 mg RECTAL OTC Monograph Drug 15 sections
Gentle Laxative HUMAN OTC DRUG LABEL 1 0363-0327 TABLET, DELAYED RELEASE 5 mg ORAL OTC Monograph Drug 15 sections
Walgreens Gentle Laxative HUMAN OTC DRUG LABEL 1 0363-0466 SUPPOSITORY 10 mg RECTAL OTC Monograph Drug 14 sections
Walgreens Gentle Laxative HUMAN OTC DRUG LABEL 1 0363-0466 SUPPOSITORY 10 mg RECTAL OTC Monograph Drug 14 sections
Walgreens Gentle Laxative HUMAN OTC DRUG LABEL 1 0363-0466 SUPPOSITORY 10 mg RECTAL OTC Monograph Drug 14 sections
Walgreens Gentle Laxative HUMAN OTC DRUG LABEL 1 0363-0468 SUPPOSITORY 10 mg RECTAL OTC Monograph Drug 13 sections
Laxative HUMAN OTC DRUG LABEL 1 0363-6760 TABLET, DELAYED RELEASE 5 mg ORAL OTC Monograph Drug 15 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 0574-7050 SUPPOSITORY 10 mg RECTAL OTC Monograph Drug 15 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 0574-7050 SUPPOSITORY 10 mg RECTAL OTC Monograph Drug 15 sections
Unit Dose Bisacodyl HUMAN OTC DRUG LABEL 1 0904-6407 TABLET, DELAYED RELEASE 5 mg ORAL OTC Monograph Drug 15 sections
Unit Dose Bisacodyl HUMAN OTC DRUG LABEL 1 0904-6407 TABLET, DELAYED RELEASE 5 mg ORAL OTC Monograph Drug 15 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 0904-6748 TABLET, DELAYED RELEASE 5 mg ORAL OTC Monograph Drug 15 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 0904-7142 SUPPOSITORY 10 mg RECTAL OTC Monograph Drug 14 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 0904-7142 SUPPOSITORY 10 mg RECTAL OTC Monograph Drug 14 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 11534-013 TABLET, DELAYED RELEASE 5 mg ORAL OTC monograph not final 13 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 11534-156 TABLET, DELAYED RELEASE 5 mg ORAL OTC monograph not final 12 sections
up and up gentle laxative HUMAN OTC DRUG LABEL 1 11673-116 TABLET, COATED 5 mg ORAL OTC Monograph Drug 15 sections
up and up gentle laxative HUMAN OTC DRUG LABEL 1 11673-116 TABLET, COATED 5 mg ORAL OTC Monograph Drug 15 sections
WOMENS GENTLE LAXATIVE HUMAN OTC DRUG LABEL 1 11673-151 TABLET 5 mg ORAL OTC monograph not final 8 sections
BISACODYL HUMAN OTC DRUG LABEL 1 11673-182 TABLET, COATED 5 mg ORAL OTC Monograph Drug 16 sections
laxative for women HUMAN OTC DRUG LABEL 1 11822-0676 TABLET, DELAYED RELEASE 5 mg ORAL OTC Monograph Drug 15 sections
Laxative HUMAN OTC DRUG LABEL 1 11822-0790 TABLET, DELAYED RELEASE 5 mg ORAL OTC Monograph Drug 15 sections
Rite Aid fast relief laxative HUMAN OTC DRUG LABEL 1 11822-4600 SUPPOSITORY 10 mg RECTAL OTC monograph not final 13 sections
Rite Aid fast relief laxative HUMAN OTC DRUG LABEL 1 11822-4601 SUPPOSITORY 10 mg RECTAL OTC monograph not final 12 sections
Rite-Aid Gentle Laxative HUMAN OTC DRUG LABEL 1 11822-4890 SUPPOSITORY 10 mg RECTAL OTC Monograph Drug 14 sections
DELAYED RELEASE LAXATIVE BISACODYL HUMAN OTC DRUG LABEL 1 11822-7850 TABLET, DELAYED RELEASE 5 mg ORAL OTC monograph not final 15 sections
Gentle Laxative Bisacodyl HUMAN OTC DRUG LABEL 1 13709-321 SUPPOSITORY 10 mg RECTAL OTC Monograph Drug 17 sections
Bisacodyl Laxative HUMAN OTC DRUG LABEL 1 13709-328 SUPPOSITORY 10 mg RECTAL OTC Monograph Drug 16 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 16103-367 TABLET, DELAYED RELEASE 5 mg ORAL OTC monograph not final 15 sections