Stem definition | Drug id | CAS RN |
---|---|---|
375 | 603-50-9 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
10 | mg | R |
Property | Value | Reference |
---|---|---|
BA (Bioavailability) | 15 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
May 10, 2004 | FDA | BRAINTREE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Macular degeneration | 384.69 | 12.48 | 156 | 17624 | 14232 | 50573112 |
Sedation complication | 276.01 | 12.48 | 107 | 17673 | 8659 | 50578685 |
Cognitive disorder | 265.38 | 12.48 | 175 | 17605 | 43948 | 50543396 |
Orthostatic hypotension | 264.52 | 12.48 | 151 | 17629 | 29330 | 50558014 |
Creatinine renal clearance decreased | 247.82 | 12.48 | 108 | 17672 | 11773 | 50575571 |
Sedation | 235.67 | 12.48 | 142 | 17638 | 30468 | 50556876 |
Hypomania | 208.41 | 12.48 | 73 | 17707 | 4432 | 50582912 |
Jaundice cholestatic | 206.85 | 12.48 | 75 | 17705 | 5036 | 50582308 |
Blood calcium decreased | 199.06 | 12.48 | 111 | 17669 | 20595 | 50566749 |
Schizophrenia | 176.57 | 12.48 | 74 | 17706 | 7323 | 50580021 |
Balance disorder | 173.04 | 12.48 | 165 | 17615 | 70425 | 50516919 |
Psychotic disorder | 142.03 | 12.48 | 91 | 17689 | 21721 | 50565623 |
Depressed level of consciousness | 132.14 | 12.48 | 124 | 17656 | 51829 | 50535515 |
Mobility decreased | 102.21 | 12.48 | 133 | 17647 | 79815 | 50507529 |
Hypotension | 96.90 | 12.48 | 238 | 17542 | 235231 | 50352113 |
Blood bilirubin increased | 96.24 | 12.48 | 84 | 17696 | 31954 | 50555390 |
Hepatotoxicity | 95.38 | 12.48 | 78 | 17702 | 27148 | 50560196 |
Fall | 92.83 | 12.48 | 293 | 17487 | 334639 | 50252705 |
Cholelithiasis | 76.76 | 12.48 | 80 | 17700 | 37893 | 50549451 |
Constipation | 75.56 | 12.48 | 187 | 17593 | 185521 | 50401823 |
Intestinal pseudo-obstruction | 71.11 | 12.48 | 21 | 17759 | 733 | 50586611 |
Toxicity to various agents | 49.88 | 12.48 | 176 | 17604 | 212323 | 50375021 |
Rheumatoid arthritis | 48.05 | 12.48 | 7 | 17773 | 202543 | 50384801 |
Alopecia | 38.51 | 12.48 | 19 | 17761 | 245028 | 50342316 |
Vomiting | 37.37 | 12.48 | 283 | 17497 | 460475 | 50126869 |
Drug intolerance | 35.95 | 12.48 | 16 | 17764 | 219088 | 50368256 |
Systemic lupus erythematosus | 35.41 | 12.48 | 4 | 17776 | 140618 | 50446726 |
Maternal exposure during pregnancy | 34.63 | 12.48 | 7 | 17773 | 159771 | 50427573 |
Treatment failure | 34.45 | 12.48 | 4 | 17776 | 137633 | 50449711 |
Joint swelling | 34.26 | 12.48 | 22 | 17758 | 245264 | 50342080 |
Contraindicated product administered | 33.40 | 12.48 | 6 | 17774 | 148952 | 50438392 |
Pneumonia | 31.53 | 12.48 | 234 | 17546 | 378167 | 50209177 |
Arthropathy | 30.17 | 12.48 | 9 | 17771 | 157897 | 50429447 |
Arthralgia | 29.08 | 12.48 | 70 | 17710 | 438632 | 50148712 |
Death | 28.69 | 12.48 | 204 | 17576 | 325175 | 50262169 |
Urinary retention | 28.01 | 12.48 | 40 | 17740 | 26150 | 50561194 |
Drug hypersensitivity | 27.04 | 12.48 | 29 | 17751 | 250981 | 50336363 |
Wound | 26.65 | 12.48 | 3 | 17777 | 105791 | 50481553 |
Loss of bladder sensation | 25.82 | 12.48 | 5 | 17775 | 25 | 50587319 |
Atonic urinary bladder | 25.51 | 12.48 | 6 | 17774 | 84 | 50587260 |
Delirium | 25.37 | 12.48 | 47 | 17733 | 38145 | 50549199 |
Hypersensitivity | 25.31 | 12.48 | 23 | 17757 | 215138 | 50372206 |
Therapeutic product effect decreased | 23.82 | 12.48 | 9 | 17771 | 136041 | 50451303 |
Nausea | 23.36 | 12.48 | 362 | 17418 | 705036 | 49882308 |
Mental status changes | 23.29 | 12.48 | 44 | 17736 | 36228 | 50551116 |
Flatulence | 21.79 | 12.48 | 38 | 17742 | 29420 | 50557924 |
Prescription drug used without a prescription | 21.65 | 12.48 | 11 | 17769 | 1689 | 50585655 |
Nasopharyngitis | 21.09 | 12.48 | 22 | 17758 | 192905 | 50394439 |
Sinusitis | 20.33 | 12.48 | 18 | 17762 | 170540 | 50416804 |
Anal sphincter atony | 19.80 | 12.48 | 6 | 17774 | 229 | 50587115 |
Hyponatraemia | 19.46 | 12.48 | 76 | 17704 | 96063 | 50491281 |
Subileus | 19.17 | 12.48 | 12 | 17768 | 2747 | 50584597 |
Body dysmorphic disorder | 19.09 | 12.48 | 6 | 17774 | 259 | 50587085 |
Hypokalaemia | 18.99 | 12.48 | 71 | 17709 | 87921 | 50499423 |
Headache | 18.80 | 12.48 | 103 | 17677 | 506432 | 50080912 |
Rash | 18.49 | 12.48 | 85 | 17695 | 437386 | 50149958 |
Abdominal pain | 18.45 | 12.48 | 144 | 17636 | 236084 | 50351260 |
Exposure during pregnancy | 18.08 | 12.48 | 10 | 17770 | 121005 | 50466339 |
Mutism | 17.77 | 12.48 | 9 | 17771 | 1372 | 50585972 |
Foreign body | 17.40 | 12.48 | 10 | 17770 | 1961 | 50585383 |
Intestinal obstruction | 16.93 | 12.48 | 32 | 17748 | 26351 | 50560993 |
Product use issue | 16.38 | 12.48 | 17 | 17763 | 149458 | 50437886 |
Drug dose titration not performed | 15.80 | 12.48 | 6 | 17774 | 458 | 50586886 |
Listless | 15.62 | 12.48 | 10 | 17770 | 2380 | 50584964 |
Musculoskeletal stiffness | 14.78 | 12.48 | 14 | 17766 | 128467 | 50458877 |
Anorgasmia | 14.76 | 12.48 | 6 | 17774 | 549 | 50586795 |
Infusion related reaction | 14.72 | 12.48 | 23 | 17757 | 169534 | 50417810 |
Ascites | 14.41 | 12.48 | 36 | 17744 | 35825 | 50551519 |
Pericoronitis | 14.28 | 12.48 | 3 | 17777 | 24 | 50587320 |
Freezing phenomenon | 14.20 | 12.48 | 7 | 17773 | 1008 | 50586336 |
Pain in extremity | 14.05 | 12.48 | 49 | 17731 | 272816 | 50314528 |
Reduced facial expression | 13.84 | 12.48 | 8 | 17772 | 1586 | 50585758 |
Infection | 13.60 | 12.48 | 25 | 17755 | 172929 | 50414415 |
Urinary tract infection | 13.51 | 12.48 | 129 | 17651 | 223891 | 50363453 |
Completed suicide | 13.35 | 12.48 | 16 | 17764 | 131873 | 50455471 |
Localised oedema | 13.09 | 12.48 | 12 | 17768 | 4855 | 50582489 |
Psoriasis | 13.05 | 12.48 | 4 | 17776 | 68996 | 50518348 |
Anticholinergic syndrome | 12.96 | 12.48 | 8 | 17772 | 1787 | 50585557 |
Product appearance confusion | 12.89 | 12.48 | 3 | 17777 | 40 | 50587304 |
Leukocytosis | 12.81 | 12.48 | 26 | 17754 | 22553 | 50564791 |
Enteral nutrition | 12.75 | 12.48 | 3 | 17777 | 42 | 50587302 |
Intestinal perforation | 12.69 | 12.48 | 17 | 17763 | 10462 | 50576882 |
Lower respiratory tract infection | 12.65 | 12.48 | 9 | 17771 | 95192 | 50492152 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Appendicolith | 139.72 | 13.72 | 53 | 12167 | 3427 | 29558880 |
Victim of child abuse | 99.55 | 13.72 | 29 | 12191 | 816 | 29561491 |
Appendicitis | 98.27 | 13.72 | 55 | 12165 | 8724 | 29553583 |
Hyponatraemia | 70.33 | 13.72 | 111 | 12109 | 67522 | 29494785 |
Respiratory depression | 69.67 | 13.72 | 52 | 12168 | 13471 | 29548836 |
Cardiogenic shock | 69.47 | 13.72 | 60 | 12160 | 19130 | 29543177 |
Sepsis | 66.32 | 13.72 | 167 | 12053 | 142515 | 29419792 |
Abdominal distension | 57.17 | 13.72 | 82 | 12138 | 45829 | 29516478 |
Stress | 56.10 | 13.72 | 56 | 12164 | 21434 | 29540873 |
Constipation | 53.39 | 13.72 | 134 | 12086 | 114026 | 29448281 |
Urinary tract infection | 53.29 | 13.72 | 102 | 12118 | 72252 | 29490055 |
Drug dependence | 44.61 | 13.72 | 49 | 12171 | 20932 | 29541375 |
Epidural lipomatosis | 44.30 | 13.72 | 15 | 12205 | 696 | 29561611 |
Ascites | 42.09 | 13.72 | 63 | 12157 | 36556 | 29525751 |
Multiple organ dysfunction syndrome | 37.00 | 13.72 | 81 | 12139 | 63035 | 29499272 |
Product prescribing error | 36.52 | 13.72 | 41 | 12179 | 17935 | 29544372 |
General physical health deterioration | 35.40 | 13.72 | 108 | 12112 | 102749 | 29459558 |
Juvenile idiopathic arthritis | 34.48 | 13.72 | 15 | 12205 | 1379 | 29560928 |
Urosepsis | 33.71 | 13.72 | 31 | 12189 | 10715 | 29551592 |
Ventricular fibrillation | 28.61 | 13.72 | 34 | 12186 | 15799 | 29546508 |
Vomiting | 28.52 | 13.72 | 167 | 12053 | 212093 | 29350214 |
Sitting disability | 27.36 | 13.72 | 7 | 12213 | 119 | 29562188 |
Abdominal pain | 26.19 | 13.72 | 118 | 12102 | 135239 | 29427068 |
Mixed dementia | 26.09 | 13.72 | 8 | 12212 | 269 | 29562038 |
Urinary retention | 21.06 | 13.72 | 43 | 12177 | 31855 | 29530452 |
Quality of life decreased | 20.12 | 13.72 | 14 | 12206 | 3248 | 29559059 |
Decubitus ulcer | 18.97 | 13.72 | 19 | 12201 | 7292 | 29555015 |
Completed suicide | 18.62 | 13.72 | 7 | 12213 | 90239 | 29472068 |
Transcription medication error | 17.80 | 13.72 | 5 | 12215 | 123 | 29562184 |
Alveolar proteinosis | 16.92 | 13.72 | 6 | 12214 | 320 | 29561987 |
Burkholderia test positive | 16.13 | 13.72 | 8 | 12212 | 991 | 29561316 |
Nausea | 15.08 | 13.72 | 184 | 12036 | 289071 | 29273236 |
Pneumonia aspiration | 14.95 | 13.72 | 41 | 12179 | 36696 | 29525611 |
Convulsive threshold lowered | 14.39 | 13.72 | 6 | 12214 | 497 | 29561810 |
Obesity | 14.34 | 13.72 | 19 | 12201 | 9844 | 29552463 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Sedation complication | 298.02 | 12.22 | 124 | 26528 | 10230 | 64461850 |
Cognitive disorder | 251.47 | 12.22 | 197 | 26455 | 54890 | 64417190 |
Creatinine renal clearance decreased | 246.51 | 12.22 | 120 | 26532 | 14301 | 64457779 |
Orthostatic hypotension | 232.68 | 12.22 | 176 | 26476 | 46562 | 64425518 |
Sedation | 214.99 | 12.22 | 160 | 26492 | 41302 | 64430778 |
Blood calcium decreased | 199.69 | 12.22 | 127 | 26525 | 25427 | 64446653 |
Hypomania | 177.25 | 12.22 | 72 | 26580 | 5582 | 64466498 |
Balance disorder | 166.60 | 12.22 | 189 | 26463 | 83737 | 64388343 |
Jaundice cholestatic | 159.83 | 12.22 | 76 | 26576 | 8594 | 64463486 |
Appendicolith | 139.82 | 12.22 | 53 | 26599 | 3416 | 64468664 |
Schizophrenia | 136.04 | 12.22 | 74 | 26578 | 11094 | 64460986 |
Mobility decreased | 107.85 | 12.22 | 154 | 26498 | 85686 | 64386394 |
Constipation | 101.78 | 12.22 | 264 | 26388 | 229073 | 64243007 |
Victim of child abuse | 98.66 | 12.22 | 29 | 26623 | 842 | 64471238 |
Fall | 97.77 | 12.22 | 385 | 26267 | 416441 | 64055639 |
Depressed level of consciousness | 97.77 | 12.22 | 143 | 26509 | 81293 | 64390787 |
Psychotic disorder | 97.49 | 12.22 | 94 | 26558 | 34484 | 64437596 |
Appendicitis | 85.52 | 12.22 | 59 | 26593 | 13510 | 64458570 |
Hyponatraemia | 79.84 | 12.22 | 184 | 26468 | 148155 | 64323925 |
Hypotension | 76.01 | 12.22 | 335 | 26317 | 380639 | 64091441 |
Drug ineffective | 64.70 | 12.22 | 159 | 26493 | 840088 | 63631992 |
Cholelithiasis | 62.12 | 12.22 | 85 | 26567 | 45421 | 64426659 |
Ascites | 59.20 | 12.22 | 98 | 26554 | 61903 | 64410177 |
Hepatotoxicity | 58.14 | 12.22 | 77 | 26575 | 39885 | 64432195 |
Vomiting | 57.66 | 12.22 | 407 | 26245 | 550710 | 63921370 |
Blood bilirubin increased | 54.98 | 12.22 | 91 | 26561 | 57462 | 64414618 |
Abdominal distension | 54.86 | 12.22 | 122 | 26530 | 95872 | 64376208 |
Intestinal pseudo-obstruction | 54.34 | 12.22 | 23 | 26629 | 1977 | 64470103 |
Cardiogenic shock | 54.29 | 12.22 | 67 | 26585 | 32360 | 64439720 |
Respiratory depression | 50.24 | 12.22 | 55 | 26597 | 23388 | 64448692 |
Sepsis | 50.03 | 12.22 | 208 | 26444 | 230133 | 64241947 |
Urinary retention | 44.60 | 12.22 | 76 | 26576 | 49125 | 64422955 |
Urinary tract infection | 42.59 | 12.22 | 199 | 26453 | 231397 | 64240683 |
Epidural lipomatosis | 41.21 | 12.22 | 15 | 26637 | 862 | 64471218 |
Rheumatoid arthritis | 38.80 | 12.22 | 10 | 26642 | 164284 | 64307796 |
Completed suicide | 37.76 | 12.22 | 23 | 26629 | 224391 | 64247689 |
Nausea | 37.27 | 12.22 | 491 | 26161 | 785309 | 63686771 |
Pneumonia | 35.53 | 12.22 | 370 | 26282 | 559206 | 63912874 |
Abdominal pain | 34.49 | 12.22 | 234 | 26418 | 312141 | 64159939 |
Arthralgia | 34.43 | 12.22 | 83 | 26569 | 442177 | 64029903 |
Drug dependence | 32.25 | 12.22 | 53 | 26599 | 33259 | 64438821 |
General physical health deterioration | 31.42 | 12.22 | 167 | 26485 | 204258 | 64267822 |
Joint swelling | 31.08 | 12.22 | 26 | 26626 | 215356 | 64256724 |
Product prescribing error | 28.75 | 12.22 | 52 | 26600 | 35217 | 64436863 |
Nasopharyngitis | 27.88 | 12.22 | 24 | 26628 | 196049 | 64276031 |
Ventricular fibrillation | 25.90 | 12.22 | 40 | 26612 | 23820 | 64448260 |
Sitting disability | 25.88 | 12.22 | 7 | 26645 | 149 | 64471931 |
Mixed dementia | 25.73 | 12.22 | 8 | 26644 | 282 | 64471798 |
Alopecia | 25.16 | 12.22 | 19 | 26633 | 165671 | 64306409 |
Juvenile idiopathic arthritis | 24.75 | 12.22 | 17 | 26635 | 3862 | 64468218 |
Atonic urinary bladder | 24.74 | 12.22 | 6 | 26646 | 81 | 64471999 |
Multiple organ dysfunction syndrome | 24.71 | 12.22 | 95 | 26557 | 101318 | 64370762 |
Treatment failure | 24.18 | 12.22 | 9 | 26643 | 116807 | 64355273 |
Quality of life decreased | 23.47 | 12.22 | 22 | 26630 | 7784 | 64464296 |
Drug intolerance | 23.27 | 12.22 | 26 | 26626 | 187966 | 64284114 |
Sinusitis | 23.11 | 12.22 | 16 | 26636 | 145912 | 64326168 |
Urosepsis | 22.54 | 12.22 | 36 | 26616 | 22058 | 64450022 |
Hypersensitivity | 22.38 | 12.22 | 29 | 26623 | 196423 | 64275657 |
Maternal exposure during pregnancy | 22.32 | 12.22 | 6 | 26646 | 95878 | 64376202 |
Decubitus ulcer | 21.36 | 12.22 | 27 | 26625 | 13352 | 64458728 |
Arthropathy | 20.89 | 12.22 | 12 | 26640 | 120955 | 64351125 |
Mental status changes | 20.77 | 12.22 | 64 | 26588 | 61098 | 64410982 |
Loss of bladder sensation | 20.45 | 12.22 | 5 | 26647 | 70 | 64472010 |
Toxicity to various agents | 20.07 | 12.22 | 234 | 26418 | 363279 | 64108801 |
Systemic lupus erythematosus | 19.76 | 12.22 | 4 | 26648 | 77608 | 64394472 |
Interstitial lung disease | 19.45 | 12.22 | 8 | 26644 | 97724 | 64374356 |
Injection site pain | 19.31 | 12.22 | 11 | 26641 | 111397 | 64360683 |
Unresponsive to stimuli | 19.27 | 12.22 | 55 | 26597 | 50338 | 64421742 |
Death | 18.91 | 12.22 | 292 | 26360 | 482413 | 63989667 |
Flatulence | 18.88 | 12.22 | 44 | 26608 | 35622 | 64436458 |
Delirium | 18.67 | 12.22 | 67 | 26585 | 69127 | 64402953 |
Stress | 18.42 | 12.22 | 61 | 26591 | 60473 | 64411607 |
Body dysmorphic disorder | 18.27 | 12.22 | 6 | 26646 | 253 | 64471827 |
Intentional product misuse | 17.83 | 12.22 | 68 | 26584 | 72227 | 64399853 |
Small intestinal obstruction | 17.02 | 12.22 | 33 | 26619 | 23540 | 64448540 |
Anal sphincter atony | 16.93 | 12.22 | 6 | 26646 | 319 | 64471761 |
Colitis ischaemic | 16.72 | 12.22 | 24 | 26628 | 13390 | 64458690 |
Neurogenic bladder | 16.61 | 12.22 | 13 | 26639 | 3606 | 64468474 |
Transcription medication error | 16.48 | 12.22 | 6 | 26646 | 345 | 64471735 |
Pain in extremity | 16.39 | 12.22 | 67 | 26585 | 303018 | 64169062 |
Pericarditis | 16.38 | 12.22 | 3 | 26649 | 62513 | 64409567 |
Leukocytosis | 16.22 | 12.22 | 43 | 26609 | 37697 | 64434383 |
Infusion related reaction | 16.07 | 12.22 | 27 | 26625 | 164440 | 64307640 |
Drug hypersensitivity | 15.92 | 12.22 | 48 | 26604 | 237767 | 64234313 |
Freezing phenomenon | 15.45 | 12.22 | 9 | 26643 | 1537 | 64470543 |
Tubulointerstitial nephritis | 15.14 | 12.22 | 37 | 26615 | 30872 | 64441208 |
Hypokalaemia | 15.05 | 12.22 | 94 | 26558 | 121809 | 64350271 |
Heparin-induced thrombocytopenia | 14.97 | 12.22 | 18 | 26634 | 8461 | 64463619 |
Dementia | 14.90 | 12.22 | 29 | 26623 | 20737 | 64451343 |
Exposure during pregnancy | 14.45 | 12.22 | 7 | 26645 | 77668 | 64394412 |
Contraindicated product administered | 14.37 | 12.22 | 14 | 26638 | 107815 | 64364265 |
Intestinal obstruction | 14.26 | 12.22 | 40 | 26612 | 36246 | 64435834 |
Therapeutic product effect decreased | 14.22 | 12.22 | 16 | 26636 | 115335 | 64356745 |
Lower respiratory tract infection | 14.16 | 12.22 | 11 | 26641 | 94603 | 64377477 |
Pain | 14.04 | 12.22 | 313 | 26339 | 553198 | 63918882 |
Headache | 13.83 | 12.22 | 146 | 26506 | 529321 | 63942759 |
Alveolar proteinosis | 13.56 | 12.22 | 6 | 26646 | 574 | 64471506 |
Failure to thrive | 13.54 | 12.22 | 19 | 26633 | 10385 | 64461695 |
Arthritis | 13.52 | 12.22 | 9 | 26643 | 83805 | 64388275 |
Prescription drug used without a prescription | 13.38 | 12.22 | 10 | 26642 | 2590 | 64469490 |
Pneumonia aspiration | 13.20 | 12.22 | 54 | 26598 | 59217 | 64412863 |
Mutism | 13.18 | 12.22 | 9 | 26643 | 2025 | 64470055 |
Subileus | 13.03 | 12.22 | 13 | 26639 | 4964 | 64467116 |
Reduced facial expression | 12.87 | 12.22 | 9 | 26643 | 2104 | 64469976 |
Peripheral swelling | 12.76 | 12.22 | 44 | 26608 | 209109 | 64262971 |
Rash | 12.56 | 12.22 | 125 | 26527 | 458424 | 64013656 |
Psoriasis | 12.54 | 12.22 | 7 | 26645 | 71696 | 64400384 |
None
Source | Code | Description |
---|---|---|
ATC | A06AB02 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Contact laxatives |
ATC | A06AB52 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Contact laxatives |
ATC | A06AG02 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Enemas |
FDA PE | N0000009371 | Increased Large Intestinal Motility |
FDA PE | N0000009871 | Stimulation Large Intestine Fluid/Electrolyte Secretion |
MeSH PA | D002400 | Cathartics |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D054368 | Laxatives |
FDA EPC | N0000175812 | Stimulant Laxative |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Constipation | indication | 14760008 | DOID:2089 |
Incomplete passage of stool | indication | 249515001 | |
Anuria | contraindication | 2472002 | DOID:2983 |
Hypocalcemia | contraindication | 5291005 | |
Rectal hemorrhage | contraindication | 12063002 | |
Hyperkalemia | contraindication | 14140009 | |
Severe chronic ulcerative colitis | contraindication | 14311001 | |
Acute vomiting | contraindication | 23971007 | |
Complete atrioventricular block | contraindication | 27885002 | |
Toxic megacolon | contraindication | 28536002 | DOID:1770 |
Anal fissure | contraindication | 30037006 | |
Gastrointestinal ulcer | contraindication | 40845000 | |
Toxic colitis | contraindication | 42359007 | |
Hypokalemia | contraindication | 43339004 | |
Chronic heart failure | contraindication | 48447003 | |
Gastrointestinal perforation | contraindication | 51875005 | |
Chronic ulcerative proctitis | contraindication | 52231000 | |
Congenital myotonia, autosomal dominant form | contraindication | 57938005 | |
Acute nephropathy | contraindication | 58574008 | |
Incontinence of feces | contraindication | 72042002 | |
Appendicitis | contraindication | 74400008 | DOID:8337 |
Hyperchloremia | contraindication | 74450001 | |
Third degree burn injury | contraindication | 80247002 | |
Intestinal obstruction | contraindication | 81060008 | DOID:8437 |
Oliguria | contraindication | 83128009 | |
Hyponatremia | contraindication | 89627008 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Gastrointestinal obstruction | contraindication | 126765001 | |
Seizure disorder | contraindication | 128613002 | |
Hyporeninemic hypoaldosteronism | contraindication | 236464008 | |
Edema | contraindication | 267038008 | |
Familial hyperkalemic periodic paralysis | contraindication | 304737009 | DOID:14451 |
Gastric retention | contraindication | 307227006 | |
At risk for aspiration | contraindication | 371736008 | |
Severe dehydration | contraindication | 450316000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.39 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
5MG,N/A;N/A,210GM;N/A,0.74GM;N/A,2.86GM;N/A,5.6GM **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | HALFLYTELY | BRAINTREE | N021551 | July 16, 2010 | DISCN | FOR SOLUTION, TABLET, DELAYED RELEASE | ORAL | 7291324 | Oct. 22, 2022 | GASTROINTESTINAL LAVAGE INDICATED FOR CLEANSING OF THE COLON AS A PREPARATION FOR COLONOSCOPY IN ADULTS |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent dopamine transporter | Transporter | Ki | 5.76 | DRUG MATRIX | |||||
Kappa-type opioid receptor | GPCR | Ki | 6.01 | DRUG MATRIX | |||||
Cytochrome P450 2C9 | Enzyme | IC50 | 5 | DRUG MATRIX |
ID | Source |
---|---|
4018526 | VUID |
N0000146848 | NUI |
D00245 | KEGG_DRUG |
151672 | RXNORM |
C0005632 | UMLSCUI |
CHEBI:3125 | CHEBI |
CHEMBL942 | ChEMBL_ID |
DB09020 | DRUGBANK_ID |
D001726 | MESH_DESCRIPTOR_UI |
2391 | PUBCHEM_CID |
824 | INN_ID |
10X0709Y6I | UNII |
4286 | MMSL |
4855 | MMSL |
d01015 | MMSL |
001172 | NDDF |
13565005 | SNOMEDCT_US |
387075009 | SNOMEDCT_US |
4018526 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Fleet | HUMAN OTC DRUG LABEL | 1 | 0132-0703 | ENEMA | 10 mg | RECTAL | OTC monograph not final | 11 sections |
Gentle Laxative | HUMAN OTC DRUG LABEL | 1 | 0363-0327 | TABLET | 5 mg | ORAL | OTC MONOGRAPH NOT FINAL | 16 sections |
Gentle Laxative | HUMAN OTC DRUG LABEL | 1 | 0363-0327 | TABLET | 5 mg | ORAL | OTC MONOGRAPH NOT FINAL | 16 sections |
Walgreens Gentle Laxative | HUMAN OTC DRUG LABEL | 1 | 0363-0466 | SUPPOSITORY | 10 mg | RECTAL | OTC monograph not final | 14 sections |
Walgreens Gentle Laxative | HUMAN OTC DRUG LABEL | 1 | 0363-0466 | SUPPOSITORY | 10 mg | RECTAL | OTC monograph not final | 14 sections |
Walgreens Gentle Laxative | HUMAN OTC DRUG LABEL | 1 | 0363-0466 | SUPPOSITORY | 10 mg | RECTAL | OTC monograph not final | 14 sections |
WOMENS GENTLE LAXATIVE | HUMAN OTC DRUG LABEL | 1 | 0363-3011 | CAPSULE, GELATIN COATED | 5 mg | ORAL | OTC monograph not final | 16 sections |
Laxative | HUMAN OTC DRUG LABEL | 1 | 0363-6760 | TABLET, COATED | 5 mg | ORAL | OTC monograph not final | 15 sections |
Rugby Gentle Laxative | HUMAN OTC DRUG LABEL | 1 | 0536-1238 | SUPPOSITORY | 10 mg | RECTAL | OTC monograph not final | 15 sections |
ENTERIC COATED STIMULANT LAXATIVE | HUMAN OTC DRUG LABEL | 1 | 0536-3381 | TABLET, DELAYED RELEASE | 5 mg | ORAL | OTC monograph not final | 6 sections |
Bisacodyl | HUMAN OTC DRUG LABEL | 1 | 0574-7050 | SUPPOSITORY | 10 mg | RECTAL | OTC monograph not final | 15 sections |
Bisacodyl | HUMAN OTC DRUG LABEL | 1 | 0615-0598 | TABLET, COATED | 5 mg | ORAL | OTC MONOGRAPH NOT FINAL | 14 sections |
Unit Dose Bisacodyl | HUMAN OTC DRUG LABEL | 1 | 0904-6407 | TABLET, DELAYED RELEASE | 5 mg | ORAL | OTC monograph not final | 15 sections |
Bisacodyl | HUMAN OTC DRUG LABEL | 1 | 0904-6748 | TABLET, COATED | 5 mg | ORAL | OTC monograph not final | 15 sections |
Leader Gentle Laxative | HUMAN OTC DRUG LABEL | 1 | 0904-6981 | SUPPOSITORY | 10 mg | RECTAL | OTC monograph not final | 15 sections |
Leader Gentle Laxative | HUMAN OTC DRUG LABEL | 1 | 0904-6981 | SUPPOSITORY | 10 mg | RECTAL | OTC monograph not final | 15 sections |
Bisacodyl | HUMAN OTC DRUG LABEL | 1 | 0904-7142 | SUPPOSITORY | 10 mg | RECTAL | OTC monograph not final | 14 sections |
Carters Little PillsSodium-Free | HUMAN OTC DRUG LABEL | 1 | 10237-906 | TABLET, DELAYED RELEASE | 5 mg | ORAL | OTC monograph not final | 11 sections |
Bisacodyl | HUMAN OTC DRUG LABEL | 1 | 11534-013 | TABLET, DELAYED RELEASE | 5 mg | ORAL | OTC monograph not final | 13 sections |
Bisacodyl | HUMAN OTC DRUG LABEL | 1 | 11534-156 | TABLET, DELAYED RELEASE | 5 mg | ORAL | OTC monograph not final | 12 sections |
LaxativeEnteric Coated | HUMAN OTC DRUG LABEL | 1 | 11673-053 | TABLET, COATED | 5 mg | ORAL | OTC MONOGRAPH NOT FINAL | 15 sections |
up and up gentle laxative | HUMAN OTC DRUG LABEL | 1 | 11673-116 | TABLET, COATED | 5 mg | ORAL | OTC monograph not final | 15 sections |
WOMENS GENTLE LAXATIVE | HUMAN OTC DRUG LABEL | 1 | 11673-151 | TABLET | 5 mg | ORAL | OTC monograph not final | 8 sections |
BISACODYL | HUMAN OTC DRUG LABEL | 1 | 11673-182 | TABLET, COATED | 5 mg | ORAL | OTC monograph not final | 7 sections |
Laxative | HUMAN OTC DRUG LABEL | 1 | 11822-0327 | TABLET, DELAYED RELEASE | 5 mg | ORAL | OTC monograph not final | 15 sections |
laxative for women | HUMAN OTC DRUG LABEL | 1 | 11822-0676 | TABLET, COATED | 5 mg | ORAL | OTC monograph not final | 15 sections |
Rite Aid fast relief laxative | HUMAN OTC DRUG LABEL | 1 | 11822-4600 | SUPPOSITORY | 10 mg | RECTAL | OTC monograph not final | 13 sections |
Rite Aid fast relief laxative | HUMAN OTC DRUG LABEL | 1 | 11822-4601 | SUPPOSITORY | 10 mg | RECTAL | OTC monograph not final | 12 sections |
DELAYED RELEASE LAXATIVE BISACODYL | HUMAN OTC DRUG LABEL | 1 | 11822-7850 | TABLET, DELAYED RELEASE | 5 mg | ORAL | OTC monograph not final | 15 sections |
Bisacodyl | HUMAN OTC DRUG LABEL | 1 | 16103-367 | TABLET, DELAYED RELEASE | 5 mg | ORAL | OTC monograph not final | 15 sections |