bisacodyl 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vasodilators 375 603-50-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bisacodyl
  • brocalax
  • dulcolax
A diphenylmethane stimulant laxative used for the treatment of CONSTIPATION and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871)
  • Molecular weight: 361.40
  • Formula: C22H19NO4
  • CLOGP: 2.85
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 65.49
  • ALOGS: -5.46
  • ROTB: 7

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg R

ADMET properties:

PropertyValueReference
BA (Bioavailability) 15 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility) 0.00 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
May 10, 2004 FDA BRAINTREE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 711.60 13.29 287 23639 24089 63441007
Sedation complication 470.63 13.29 182 23744 13640 63451456
Orthostatic hypotension 460.29 13.29 239 23687 35921 63429175
Creatinine renal clearance decreased 438.06 13.29 181 23745 16127 63448969
Cognitive disorder 428.68 13.29 265 23661 55550 63409546
Sedation 405.56 13.29 225 23701 38584 63426512
Blood calcium decreased 363.06 13.29 184 23742 26267 63438829
Hypomania 314.05 13.29 110 23816 6220 63458876
Jaundice cholestatic 305.77 13.29 112 23814 7212 63457884
Balance disorder 304.43 13.29 253 23673 84169 63380927
Schizophrenia 272.42 13.29 112 23814 9840 63455256
Depressed level of consciousness 246.78 13.29 197 23729 61881 63403215
Psychotic disorder 214.94 13.29 129 23797 25583 63439513
Hypotension 163.65 13.29 334 23592 272270 63192826
Blood bilirubin increased 158.57 13.29 123 23803 37017 63428079
Mobility decreased 155.14 13.29 209 23717 120950 63344146
Hepatotoxicity 143.80 13.29 116 23810 36925 63428171
Fall 141.31 13.29 394 23532 391940 63073156
Chronic sinusitis 135.49 13.29 75 23851 12768 63452328
Cholelithiasis 132.51 13.29 119 23807 43806 63421290
Constipation 124.80 13.29 267 23659 224676 63240420
Paraesthesia oral 119.38 13.29 80 23846 19176 63445920
Procedural pain 108.89 13.29 79 23847 21490 63443606
Asthma-chronic obstructive pulmonary disease overlap syndrome 106.76 13.29 37 23889 2024 63463072
Total lung capacity increased 102.63 13.29 37 23889 2273 63462823
Toxicity to various agents 99.54 13.29 259 23667 246991 63218105
Vaginal flatulence 83.15 13.29 35 23891 3258 63461838
Proctitis 72.11 13.29 37 23889 5404 63459692
Nasal polyps 71.28 13.29 38 23888 6001 63459095
Rheumatoid arthritis 70.51 13.29 7 23919 253812 63211284
Intestinal pseudo-obstruction 69.85 13.29 22 23904 890 63464206
Drug intolerance 68.79 13.29 16 23910 308645 63156451
Alopecia 68.61 13.29 21 23905 337515 63127581
Bronchiectasis 63.57 13.29 51 23875 16091 63449005
Systemic lupus erythematosus 62.93 13.29 4 23922 208914 63256182
Sarcoidosis 62.78 13.29 37 23889 7085 63458011
Multiple drug therapy 60.83 13.29 29 23897 3617 63461479
Arthropathy 59.04 13.29 9 23917 234783 63230313
Joint swelling 58.76 13.29 25 23901 327641 63137455
Maternal exposure during pregnancy 58.75 13.29 7 23919 220055 63245041
Contraindicated product administered 57.91 13.29 7 23919 217641 63247455
Treatment failure 56.57 13.29 5 23921 199038 63266058
Female genital tract fistula 55.67 13.29 35 23891 7524 63457572
Vaginal discharge 51.74 13.29 36 23890 9162 63455934
Radiculopathy 51.50 13.29 35 23891 8576 63456520
Rhinitis allergic 50.37 13.29 39 23887 11688 63453408
Cardiac murmur 46.99 13.29 41 23885 14511 63450585
Arthralgia 46.78 13.29 90 23836 569620 62895476
Wound 46.66 13.29 4 23922 163259 63301837
Hypersensitivity 44.05 13.29 28 23898 292657 63172439
Therapeutic product effect decreased 43.03 13.29 10 23916 193177 63271919
Nausea 40.05 13.29 494 23432 853977 62611119
Rash 39.09 13.29 97 23829 560774 62904322
Pericarditis 35.56 13.29 4 23922 131575 63333521
Oral candidiasis 34.87 13.29 43 23883 22755 63442341
Pneumonia 34.75 13.29 292 23634 456475 63008621
Nasopharyngitis 34.72 13.29 27 23899 254230 63210866
Product use issue 34.70 13.29 20 23906 220500 63244596
Lung neoplasm malignant 33.25 13.29 39 23887 19594 63445502
Drug hypersensitivity 33.18 13.29 41 23885 310646 63154450
Frequent bowel movements 32.94 13.29 42 23884 22980 63442116
Vomiting 31.25 13.29 335 23591 559282 62905814
Chronic obstructive pulmonary disease 30.80 13.29 71 23855 62615 63402481
Pain 30.75 13.29 419 23507 740209 62724887
Sinusitis 29.78 13.29 25 23901 226628 63238468
Exposure during pregnancy 29.26 13.29 11 23915 155536 63309560
Urinary retention 28.16 13.29 45 23881 30256 63434840
Abdominal pain 27.49 13.29 197 23729 293259 63171837
Abdominal discomfort 26.87 13.29 50 23876 320835 63144261
Swelling 25.73 13.29 40 23886 275338 63189758
Atonic urinary bladder 25.09 13.29 6 23920 84 63465012
Oedema peripheral 25.08 13.29 139 23787 189372 63275724
Colitis 24.99 13.29 56 23870 48472 63416624
Infection 24.71 13.29 30 23896 229143 63235953
Death 24.65 13.29 232 23694 374149 63090947
Dyspepsia 23.28 13.29 88 23838 102108 63362988
Colitis ulcerative 23.22 13.29 38 23888 26053 63439043
Peripheral swelling 22.65 13.29 41 23885 265901 63199195
Prescription drug used without a prescription 22.63 13.29 13 23913 2373 63462723
Loss of bladder sensation 22.10 13.29 5 23921 54 63465042
Pain in extremity 21.75 13.29 59 23867 331427 63133669
Haematochezia 21.37 13.29 56 23870 53488 63411608
Total lung capacity decreased 20.99 13.29 12 23914 2171 63462925
Listless 20.45 13.29 13 23913 2847 63462249
Psoriasis 20.37 13.29 4 23922 86953 63378143
Foreign body 20.22 13.29 12 23914 2326 63462770
Mental status changes 19.61 13.29 45 23881 39554 63425542
Reduced facial expression 19.42 13.29 11 23915 1955 63463141
Completed suicide 19.20 13.29 16 23910 145657 63319439
Anal sphincter atony 19.02 13.29 6 23920 244 63464852
Arthritis 18.97 13.29 10 23916 115911 63349185
Flatulence 18.94 13.29 41 23885 34661 63430435
Fatigue 18.63 13.29 230 23696 887798 62577298
Impaired healing 18.06 13.29 8 23918 102534 63362562
Musculoskeletal stiffness 18.02 13.29 26 23900 184592 63280504
Bronchopulmonary aspergillosis allergic 18.01 13.29 11 23915 2247 63462849
Drug dose titration not performed 17.91 13.29 7 23919 538 63464558
Hypoxia 17.54 13.29 56 23870 59736 63405360
Female sexual arousal disorder 17.53 13.29 4 23922 45 63465051
Anticholinergic syndrome 17.46 13.29 11 23915 2371 63462725
Delirium 17.32 13.29 50 23876 50491 63414605
Body dysmorphic disorder 17.14 13.29 6 23920 338 63464758
Folliculitis 16.98 13.29 3 23923 70314 63394782
Lung opacity 16.89 13.29 12 23914 3156 63461940
Subileus 16.85 13.29 12 23914 3167 63461929
Gastrooesophageal reflux disease 16.78 13.29 76 23850 95563 63369533
Gastrointestinal disorder 16.59 13.29 15 23911 131224 63333872
Urticaria 16.53 13.29 23 23903 165779 63299317
Hypokalaemia 16.39 13.29 80 23846 103724 63361372
Rectal haemorrhage 16.32 13.29 48 23878 48982 63416114
Weight decreased 15.99 13.29 167 23759 276631 63188465
Oesophageal hypomotility 15.88 13.29 5 23921 202 63464894
Mutism 15.78 13.29 9 23917 1621 63463475
Irritable bowel syndrome 15.21 13.29 6 23920 82406 63382690
Intestinal obstruction 15.17 13.29 35 23891 30864 63434232
Discomfort 14.97 13.29 25 23901 167349 63297747
Hyponatraemia 14.73 13.29 82 23844 111818 63353278
Interstitial lung disease 14.19 13.29 3 23923 61905 63403191
Pelvic fracture 14.05 13.29 21 23905 13327 63451769
Headache 14.01 13.29 162 23764 633079 62832017
Injection site pain 13.97 13.29 17 23909 129783 63335313
Anorgasmia 13.87 13.29 6 23920 597 63464499
Pericoronitis 13.76 13.29 3 23923 27 63465069

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 288.16 13.31 118 15802 8483 34932528
Appendicitis 232.62 13.31 120 15800 14687 34926324
Cardiogenic shock 179.18 13.31 125 15795 26493 34914518
Stress 157.89 13.31 122 15798 30225 34910786
Blood phosphorus increased 146.03 13.31 71 15849 7650 34933361
Ventricular fibrillation 138.80 13.31 101 15819 22853 34918158
Hyponatraemia 136.75 13.31 178 15742 82513 34858498
Abdominal distension 136.36 13.31 150 15770 58342 34882669
Ascites 130.94 13.31 132 15788 46439 34894572
Sepsis 115.48 13.31 242 15678 166319 34774692
Respiratory depression 101.65 13.31 73 15847 16172 34924839
Victim of child abuse 98.36 13.31 30 15890 897 34940114
Multiple organ dysfunction syndrome 98.33 13.31 146 15774 76420 34864591
General physical health deterioration 93.06 13.31 190 15730 128079 34812932
Dry mouth 80.18 13.31 83 15837 30082 34910929
Epidural lipomatosis 78.29 13.31 26 15894 1028 34939983
Drug dependence 68.65 13.31 69 15851 24148 34916863
Abdominal pain 65.64 13.31 193 15727 163425 34777586
Juvenile idiopathic arthritis 63.40 13.31 26 15894 1871 34939140
Vomiting 61.59 13.31 249 15671 247372 34693639
Myasthenia gravis 59.70 13.31 38 15882 6902 34934109
Product prescribing error 55.43 13.31 60 15860 22867 34918144
Blood uric acid increased 55.10 13.31 41 15879 9583 34931428
Urinary tract infection 46.67 13.31 112 15808 83969 34857042
Constipation 46.01 13.31 152 15768 136830 34804181
Intestinal pseudo-obstruction 38.86 13.31 18 15902 1738 34939273
Drug therapy 35.97 13.31 15 15905 1126 34939885
Intentional product misuse 34.68 13.31 69 15851 45542 34895469
Analgesic therapy 34.45 13.31 14 15906 984 34940027
Somnolence 34.37 13.31 120 15800 110996 34830015
Hyperphosphataemia 32.56 13.31 22 15898 4415 34936596
Nausea 32.11 13.31 264 15656 339644 34601367
Sleep disorder therapy 30.75 13.31 13 15907 1010 34940001
Urosepsis 30.06 13.31 33 15887 12766 34928245
Incorrect route of product administration 29.33 13.31 35 15885 14810 34926201
Iron deficiency 28.75 13.31 22 15898 5359 34935652
Blood cholesterol increased 27.50 13.31 40 15880 20503 34920508
Neuralgia 25.63 13.31 33 15887 15080 34925931
Mixed dementia 25.30 13.31 8 15912 270 34940741
Obesity 24.85 13.31 30 15890 12848 34928163
Completed suicide 24.77 13.31 7 15913 98161 34842850
Sitting disability 23.35 13.31 7 15913 197 34940814
Urinary retention 18.68 13.31 47 15873 36241 34904770
Hypogonadism 18.53 13.31 12 15908 2243 34938768
Arthralgia 17.22 13.31 32 15888 170009 34771002
Cerebral hypoperfusion 16.89 13.31 7 15913 517 34940494
Quality of life decreased 16.37 13.31 14 15906 3987 34937024
Hypophosphataemia 15.53 13.31 22 15898 11004 34930007
Transcription medication error 15.35 13.31 5 15915 186 34940825
Burkholderia test positive 15.21 13.31 8 15912 1015 34939996
Child abuse 14.77 13.31 6 15914 421 34940590
Drug ineffective 14.39 13.31 136 15784 456615 34484396
Decubitus ulcer 14.38 13.31 19 15901 8902 34932109
Alveolar proteinosis 14.01 13.31 6 15914 481 34940530
Convulsive threshold lowered 13.44 13.31 6 15914 532 34940479

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sedation complication 459.47 12.60 195 35774 15474 79692945
Creatinine renal clearance decreased 404.67 12.60 189 35780 18813 79689606
Cognitive disorder 368.18 12.60 282 35687 69644 79638775
Orthostatic hypotension 366.87 12.60 258 35711 55906 79652513
Blood calcium decreased 333.82 12.60 197 35772 31622 79676797
Sedation 331.07 12.60 235 35734 51660 79656759
Appendicolith 286.27 12.60 117 35852 8434 79699985
Hypomania 272.44 12.60 109 35860 7435 79700984
Balance disorder 268.80 12.60 274 35695 98583 79609836
Jaundice cholestatic 242.57 12.60 113 35856 11171 79697248
Schizophrenia 209.01 12.60 113 35856 15327 79693092
Appendicitis 203.12 12.60 123 35846 20671 79687748
Depressed level of consciousness 168.89 12.60 213 35756 96439 79611980
Mobility decreased 154.16 12.60 230 35739 121945 79586474
Psychotic disorder 145.00 12.60 132 35837 41270 79667149
Cardiogenic shock 141.66 12.60 131 35838 41783 79666636
Constipation 138.50 12.60 357 35612 282693 79425726
Ascites 135.92 12.60 169 35800 75393 79633026
Blood phosphorus increased 129.73 12.60 72 35897 10275 79698144
Macular degeneration 129.17 12.60 74 35895 11222 79697197
Hyponatraemia 121.72 12.60 256 35713 177592 79530827
Fall 120.25 12.60 486 35483 487143 79221276
Ventricular fibrillation 120.11 12.60 106 35863 31820 79676599
Chronic sinusitis 119.40 12.60 74 35895 12952 79695467
Abdominal distension 112.33 12.60 197 35772 119453 79588966
Hypotension 107.02 12.60 437 35532 439880 79268539
Intestinal pseudo-obstruction 105.78 12.60 41 35928 2568 79705851
Cholelithiasis 104.81 12.60 124 35845 52540 79655879
Victim of child abuse 97.81 12.60 30 35939 923 79707496
Paraesthesia oral 97.74 12.60 78 35891 20393 79688026
Total lung capacity increased 96.33 12.60 37 35932 2261 79706158
Blood bilirubin increased 94.15 12.60 132 35837 66100 79642319
Hepatotoxicity 92.56 12.60 115 35854 51237 79657182
Procedural pain 89.55 12.60 78 35891 23006 79685413
Asthma-chronic obstructive pulmonary disease overlap syndrome 84.25 12.60 37 35932 3184 79705235
Vaginal flatulence 81.98 12.60 34 35935 2541 79705878
Sepsis 77.27 12.60 282 35687 269146 79439273
Epidural lipomatosis 74.63 12.60 26 35943 1202 79707217
Vomiting 74.43 12.60 534 35435 665294 79043125
Abdominal pain 73.67 12.60 359 35610 389210 79319209
Respiratory depression 72.12 12.60 75 35894 27555 79680864
Nausea 69.57 12.60 697 35272 956499 78751920
Stress 68.19 12.60 126 35843 79486 79628933
Multiple organ dysfunction syndrome 66.40 12.60 159 35810 120087 79588332
General physical health deterioration 61.90 12.60 267 35702 274971 79433448
Rheumatoid arthritis 59.52 12.60 11 35958 208459 79499960
Nasal polyps 58.13 12.60 38 35931 7289 79701130
Arthralgia 57.98 12.60 106 35863 571697 79136722
Multiple drug therapy 55.60 12.60 30 35939 4048 79704371
Proctitis 55.07 12.60 35 35934 6397 79702022
Female genital tract fistula 54.90 12.60 34 35935 5941 79702478
Joint swelling 53.42 12.60 32 35937 288614 79419805
Drug ineffective 52.87 12.60 280 35689 1080633 78627786
Completed suicide 51.79 12.60 23 35946 245744 79462675
Sarcoidosis 51.38 12.60 37 35932 8298 79700121
Vaginal discharge 50.34 12.60 35 35934 7428 79700991
Drug dependence 50.28 12.60 76 35893 40693 79667726
Alopecia 49.78 12.60 21 35948 231334 79477085
Blood uric acid increased 49.52 12.60 44 35925 13316 79695103
Bronchiectasis 46.67 12.60 54 35915 22332 79686087
Myasthenia gravis 46.20 12.60 38 35931 10361 79698058
Juvenile idiopathic arthritis 46.05 12.60 28 35941 4735 79703684
Arthropathy 45.20 12.60 12 35957 177099 79531320
Radiculopathy 45.09 12.60 35 35934 8789 79699630
Treatment failure 44.57 12.60 11 35958 170475 79537944
Nasopharyngitis 43.10 12.60 31 35938 253850 79454569
Urinary retention 42.79 12.60 85 35884 56545 79651874
Rhinitis allergic 42.70 12.60 39 35930 12230 79696189
Hypersensitivity 41.99 12.60 34 35935 262205 79446214
Maternal exposure during pregnancy 41.66 12.60 6 35963 136532 79571887
Systemic lupus erythematosus 40.22 12.60 4 35965 121145 79587274
Product prescribing error 39.72 12.60 72 35897 44741 79663678
Cardiac murmur 39.59 12.60 42 35927 15782 79692637
Pain 38.40 12.60 485 35484 703317 79005102
Chronic obstructive pulmonary disease 35.89 12.60 102 35867 85317 79623102
Drug therapy 35.36 12.60 15 35954 1186 79707233
Analgesic therapy 34.43 12.60 14 35955 995 79707424
Sinusitis 34.33 12.60 23 35946 195478 79512941
Pneumonia 34.31 12.60 451 35518 659795 79048624
Toxicity to various agents 32.87 12.60 312 35657 421228 79287191
Contraindicated product administered 32.77 12.60 15 35954 157523 79550896
Therapeutic product effect decreased 31.97 12.60 17 35952 163846 79544573
Intentional product misuse 31.90 12.60 105 35864 95060 79613359
Sleep disorder therapy 30.85 12.60 13 35956 1011 79707408
Rash 30.31 12.60 146 35823 578212 79130207
Pain in extremity 29.88 12.60 76 35893 364462 79343957
Hyperphosphataemia 29.80 12.60 24 35945 6352 79702067
Urinary tract infection 29.26 12.60 218 35751 274294 79434125
Pericarditis 28.69 12.60 6 35963 104230 79604189
Peripheral swelling 26.36 12.60 51 35918 269566 79438853
Dry mouth 25.90 12.60 93 35876 87926 79620493
Drug intolerance 25.79 12.60 50 35919 264069 79444350
Frequent bowel movements 25.59 12.60 47 35922 29492 79678927
Exposure during pregnancy 25.52 12.60 7 35962 101125 79607294
Total lung capacity decreased 25.35 12.60 16 35953 2889 79705530
Mixed dementia 25.01 12.60 8 35961 283 79708136
Wound 24.26 12.60 11 35958 116168 79592251
Atonic urinary bladder 24.22 12.60 6 35963 81 79708338
Injection site pain 23.16 12.60 15 35954 129823 79578596
Interstitial lung disease 22.98 12.60 11 35958 112589 79595830
Bronchopulmonary aspergillosis allergic 22.17 12.60 15 35954 3046 79705373
Diarrhoea 22.03 12.60 273 35696 880216 78828203
Death 21.93 12.60 368 35601 566146 79142273
Abdominal discomfort 21.53 12.60 51 35918 250676 79457743
Quality of life decreased 21.49 12.60 25 35944 10395 79698024
Hypogonadism 21.39 12.60 12 35957 1748 79706671
Arthritis 20.86 12.60 13 35956 114867 79593552
Oral candidiasis 20.63 12.60 43 35926 29585 79678834
Fatigue 20.46 12.60 296 35673 929431 78778988
Therapy non-responder 20.45 12.60 8 35961 92297 79616122
Dyspepsia 19.64 12.60 99 35870 108588 79599831
Psoriasis 19.47 12.60 8 35961 89579 79618840
Iron deficiency 19.41 12.60 24 35945 10630 79697789
Lung opacity 19.09 12.60 17 35952 5157 79703262
Urosepsis 19.09 12.60 39 35930 26456 79681963
Sitting disability 18.84 12.60 7 35962 390 79708029
Loss of bladder sensation 18.54 12.60 5 35964 96 79708323
Small intestinal obstruction 18.31 12.60 39 35930 27233 79681186
Therapeutic response decreased 18.08 12.60 4 35965 66849 79641570
Colitis ischaemic 18.04 12.60 28 35941 15331 79693088
Inflammation 17.88 12.60 10 35959 93743 79614676
Decubitus ulcer 17.60 12.60 28 35941 15659 79692760
Gastrointestinal disorder 17.00 12.60 18 35951 122187 79586232
Weight increased 16.95 12.60 66 35903 277320 79431099
Cough 16.72 12.60 97 35872 366692 79341727
Lung neoplasm malignant 16.69 12.60 38 35931 27754 79680665
Hypoxia 16.56 12.60 91 35878 103152 79605267
Body dysmorphic disorder 16.42 12.60 6 35963 319 79708100
Reduced facial expression 16.42 12.60 12 35957 2753 79705666
Lung disorder 16.24 12.60 8 35961 80549 79627870
Somnolence 16.22 12.60 172 35797 238809 79469610
Anal sphincter atony 16.19 12.60 6 35963 332 79708087
Visual impairment 15.95 12.60 11 35958 92120 79616299
Foreign body 15.93 12.60 12 35957 2882 79705537
Neurogenic bladder 15.86 12.60 14 35955 4198 79704221
Impaired healing 15.80 12.60 10 35959 87645 79620774
Hypophosphataemia 15.17 12.60 30 35939 19883 79688536
Mental status changes 15.04 12.60 65 35904 66894 79641525
Colitis 14.84 12.60 69 35900 73238 79635181
Child abuse 14.80 12.60 6 35963 423 79707996
Unresponsive to stimuli 14.78 12.60 57 35912 55731 79652688
Transcription medication error 14.54 12.60 6 35963 443 79707976
Neuralgia 14.15 12.60 40 35929 33344 79675075
Injection site erythema 13.99 12.60 9 35960 78188 79630231
Functional gastrointestinal disorder 13.84 12.60 14 35955 4976 79703443
Infection 13.83 12.60 59 35910 241653 79466766
Headache 13.36 12.60 211 35758 653561 79054858
Flatulence 13.30 12.60 46 35923 42678 79665741
Intentional product use issue 13.00 12.60 31 35938 152081 79556338
Freezing phenomenon 12.96 12.60 9 35960 1905 79706514
Listless 12.91 12.60 12 35957 3849 79704570
Leukocytosis 12.85 12.60 46 35923 43409 79665010
Urticaria 12.68 12.60 42 35927 185159 79523260
Ill-defined disorder 12.60 12.60 7 35962 65868 79642551

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A06AB02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Contact laxatives
ATC A06AB52 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Contact laxatives
ATC A06AG02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Enemas
FDA PE N0000009371 Increased Large Intestinal Motility
FDA PE N0000009871 Stimulation Large Intestine Fluid/Electrolyte Secretion
MeSH PA D002400 Cathartics
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054368 Laxatives
FDA EPC N0000175812 Stimulant Laxative

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089
Incomplete passage of stool indication 249515001
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Rectal hemorrhage contraindication 12063002
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Acute vomiting contraindication 23971007
Complete atrioventricular block contraindication 27885002
Toxic megacolon contraindication 28536002 DOID:1770
Anal fissure contraindication 30037006
Gastrointestinal ulcer contraindication 40845000
Toxic colitis contraindication 42359007
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Gastrointestinal perforation contraindication 51875005
Chronic ulcerative proctitis contraindication 52231000
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Incontinence of feces contraindication 72042002
Appendicitis contraindication 74400008 DOID:8337
Hyperchloremia contraindication 74450001
Third degree burn injury contraindication 80247002
Intestinal obstruction contraindication 81060008 DOID:8437
Oliguria contraindication 83128009
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Gastrointestinal obstruction contraindication 126765001
Seizure disorder contraindication 128613002
Hyporeninemic hypoaldosteronism contraindication 236464008
Edema contraindication 267038008
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Gastric retention contraindication 307227006
At risk for aspiration contraindication 371736008
Severe dehydration contraindication 450316000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent dopamine transporter Transporter Ki 5.76 DRUG MATRIX
Kappa-type opioid receptor GPCR Ki 6.01 DRUG MATRIX
Cytochrome P450 2C9 Enzyme IC50 5 DRUG MATRIX

External reference:

IDSource
4018526 VUID
N0000146848 NUI
D00245 KEGG_DRUG
151672 RXNORM
C0005632 UMLSCUI
CHEBI:3125 CHEBI
CHEMBL942 ChEMBL_ID
DB09020 DRUGBANK_ID
D001726 MESH_DESCRIPTOR_UI
2391 PUBCHEM_CID
824 INN_ID
10X0709Y6I UNII
4286 MMSL
4855 MMSL
d01015 MMSL
13565005 SNOMEDCT_US
387075009 SNOMEDCT_US
4018526 VANDF
001172 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fleet HUMAN OTC DRUG LABEL 1 0132-0703 ENEMA 10 mg RECTAL OTC monograph not final 11 sections
Gentle Laxative HUMAN OTC DRUG LABEL 1 0363-0327 TABLET 5 mg ORAL OTC MONOGRAPH NOT FINAL 16 sections
Gentle Laxative HUMAN OTC DRUG LABEL 1 0363-0327 TABLET 5 mg ORAL OTC MONOGRAPH NOT FINAL 16 sections
Gentle Laxative HUMAN OTC DRUG LABEL 1 0363-0327 TABLET 5 mg ORAL OTC MONOGRAPH NOT FINAL 16 sections
Walgreens Gentle Laxative HUMAN OTC DRUG LABEL 1 0363-0466 SUPPOSITORY 10 mg RECTAL OTC monograph not final 14 sections
Walgreens Gentle Laxative HUMAN OTC DRUG LABEL 1 0363-0466 SUPPOSITORY 10 mg RECTAL OTC monograph not final 14 sections
Walgreens Gentle Laxative HUMAN OTC DRUG LABEL 1 0363-0466 SUPPOSITORY 10 mg RECTAL OTC monograph not final 14 sections
Walgreens Gentle Laxative HUMAN OTC DRUG LABEL 1 0363-0466 SUPPOSITORY 10 mg RECTAL OTC monograph not final 14 sections
Walgreens Gentle Laxative HUMAN OTC DRUG LABEL 1 0363-0466 SUPPOSITORY 10 mg RECTAL OTC monograph not final 14 sections
Walgreens Gentle Laxative HUMAN OTC DRUG LABEL 1 0363-0466 SUPPOSITORY 10 mg RECTAL OTC monograph not final 14 sections
WOMENS GENTLE LAXATIVE HUMAN OTC DRUG LABEL 1 0363-3011 CAPSULE, GELATIN COATED 5 mg ORAL OTC monograph not final 16 sections
WOMENS GENTLE LAXATIVE HUMAN OTC DRUG LABEL 1 0363-3011 CAPSULE, GELATIN COATED 5 mg ORAL OTC monograph not final 16 sections
Laxative HUMAN OTC DRUG LABEL 1 0363-6760 TABLET, COATED 5 mg ORAL OTC monograph not final 15 sections
Laxative HUMAN OTC DRUG LABEL 1 0363-6760 TABLET, COATED 5 mg ORAL OTC monograph not final 15 sections
Rugby Gentle Laxative HUMAN OTC DRUG LABEL 1 0536-1238 SUPPOSITORY 10 mg RECTAL OTC monograph not final 15 sections
ENTERIC COATED STIMULANT LAXATIVE HUMAN OTC DRUG LABEL 1 0536-3381 TABLET, DELAYED RELEASE 5 mg ORAL OTC monograph not final 6 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 0574-7050 SUPPOSITORY 10 mg RECTAL OTC monograph not final 15 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 0615-0598 TABLET, COATED 5 mg ORAL OTC MONOGRAPH NOT FINAL 14 sections
Unit Dose Bisacodyl HUMAN OTC DRUG LABEL 1 0904-6407 TABLET, DELAYED RELEASE 5 mg ORAL OTC monograph not final 15 sections
Unit Dose Bisacodyl HUMAN OTC DRUG LABEL 1 0904-6407 TABLET, DELAYED RELEASE 5 mg ORAL OTC monograph not final 15 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 0904-6748 TABLET, COATED 5 mg ORAL OTC monograph not final 15 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 0904-6748 TABLET, COATED 5 mg ORAL OTC monograph not final 15 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 0904-6748 TABLET, COATED 5 mg ORAL OTC monograph not final 15 sections
Leader Gentle Laxative HUMAN OTC DRUG LABEL 1 0904-6981 SUPPOSITORY 10 mg RECTAL OTC monograph not final 15 sections
Leader Gentle Laxative HUMAN OTC DRUG LABEL 1 0904-6981 SUPPOSITORY 10 mg RECTAL OTC monograph not final 15 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 0904-7142 SUPPOSITORY 10 mg RECTAL OTC monograph not final 14 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 0904-7142 SUPPOSITORY 10 mg RECTAL OTC monograph not final 14 sections
Carters Little PillsSodium-Free HUMAN OTC DRUG LABEL 1 10237-906 TABLET, DELAYED RELEASE 5 mg ORAL OTC monograph not final 11 sections
Carters Little PillsSodium-Free HUMAN OTC DRUG LABEL 1 10237-906 TABLET, DELAYED RELEASE 5 mg ORAL OTC monograph not final 11 sections
Bisacodyl HUMAN OTC DRUG LABEL 1 11534-013 TABLET, DELAYED RELEASE 5 mg ORAL OTC monograph not final 13 sections