lactulose 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1536 | 4618-18-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887)
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 6.70 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 1669.38 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 3 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| S (Water solubility) | 68 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 25, 1976 | FDA | ||
| Sept. 21, 2018 | PMDA | Sanwa Kagaku Kenkyusho Co., Ltd. |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Sedation complication | 760.70 | 11.24 | 325 | 54680 | 13497 | 63420520 |
| Orthostatic hypotension | 747.51 | 11.24 | 437 | 54568 | 35723 | 63398294 |
| Creatinine renal clearance decreased | 718.52 | 11.24 | 328 | 54677 | 15980 | 63418037 |
| Sedation | 635.30 | 11.24 | 404 | 54601 | 38405 | 63395612 |
| Cognitive disorder | 621.59 | 11.24 | 458 | 54547 | 55357 | 63378660 |
| Blood calcium decreased | 590.06 | 11.24 | 336 | 54669 | 26115 | 63407902 |
| Balance disorder | 490.19 | 11.24 | 476 | 54529 | 83946 | 63350071 |
| Depressed level of consciousness | 475.70 | 11.24 | 409 | 54596 | 61669 | 63372348 |
| Drug ineffective | 372.62 | 11.24 | 224 | 54781 | 1044541 | 62389476 |
| Hepatic encephalopathy | 322.68 | 11.24 | 169 | 54836 | 11113 | 63422904 |
| Constipation | 295.24 | 11.24 | 621 | 54384 | 224322 | 63209695 |
| Fall | 280.69 | 11.24 | 860 | 54145 | 391474 | 63042543 |
| Hypotension | 239.71 | 11.24 | 644 | 54361 | 271960 | 63162057 |
| Jaundice cholestatic | 227.54 | 11.24 | 116 | 54889 | 7208 | 63426809 |
| Hypomania | 213.50 | 11.24 | 106 | 54899 | 6224 | 63427793 |
| Mobility decreased | 204.29 | 11.24 | 372 | 54633 | 120787 | 63313230 |
| Schizophrenia | 196.85 | 11.24 | 117 | 54888 | 9835 | 63424182 |
| Blood bilirubin increased | 176.25 | 11.24 | 188 | 54817 | 36952 | 63397065 |
| Ammonia increased | 175.13 | 11.24 | 84 | 54921 | 4572 | 63429445 |
| Drug intolerance | 151.89 | 11.24 | 40 | 54965 | 308621 | 63125396 |
| Arthropathy | 149.63 | 11.24 | 15 | 54990 | 234777 | 63199240 |
| Drug hypersensitivity | 147.77 | 11.24 | 43 | 54962 | 310644 | 63123373 |
| Psychotic disorder | 143.44 | 11.24 | 142 | 54863 | 25570 | 63408447 |
| Synovitis | 143.36 | 11.24 | 4 | 55001 | 186914 | 63247103 |
| Treatment failure | 140.13 | 11.24 | 8 | 54997 | 199035 | 63234982 |
| Systemic lupus erythematosus | 139.46 | 11.24 | 11 | 54994 | 208907 | 63225110 |
| Hyponatraemia | 135.08 | 11.24 | 299 | 54706 | 111601 | 63322416 |
| Faecaloma | 128.14 | 11.24 | 82 | 54923 | 7859 | 63426158 |
| Glossodynia | 123.46 | 11.24 | 8 | 54997 | 178868 | 63255149 |
| Contraindicated product administered | 121.73 | 11.24 | 21 | 54984 | 217627 | 63216390 |
| Swelling | 120.54 | 11.24 | 44 | 54961 | 275334 | 63158683 |
| Hand deformity | 120.15 | 11.24 | 4 | 55001 | 159453 | 63274564 |
| Maternal exposure during pregnancy | 119.27 | 11.24 | 23 | 54982 | 220039 | 63213978 |
| Rheumatoid arthritis | 119.06 | 11.24 | 36 | 54969 | 253783 | 63180234 |
| Toxicity to various agents | 115.71 | 11.24 | 472 | 54533 | 246778 | 63187239 |
| Inability to afford medication | 115.38 | 11.24 | 51 | 54954 | 2296 | 63431721 |
| Joint swelling | 112.15 | 11.24 | 73 | 54932 | 327593 | 63106424 |
| Cholelithiasis | 105.11 | 11.24 | 158 | 54847 | 43767 | 63390250 |
| Infusion related reaction | 101.23 | 11.24 | 43 | 54962 | 245478 | 63188539 |
| Therapeutic product effect decreased | 98.91 | 11.24 | 23 | 54982 | 193164 | 63240853 |
| Sinusitis | 97.84 | 11.24 | 37 | 54968 | 226616 | 63207401 |
| Discomfort | 91.72 | 11.24 | 17 | 54988 | 167357 | 63266660 |
| Ascites | 89.71 | 11.24 | 141 | 54864 | 40587 | 63393430 |
| Alopecia | 88.74 | 11.24 | 97 | 54908 | 337439 | 63096578 |
| Completed suicide | 86.09 | 11.24 | 12 | 54993 | 145661 | 63288356 |
| Hepatic cirrhosis | 84.96 | 11.24 | 106 | 54899 | 24628 | 63409389 |
| Hyperkalaemia | 80.77 | 11.24 | 158 | 54847 | 54045 | 63379972 |
| Asthma-chronic obstructive pulmonary disease overlap syndrome | 80.00 | 11.24 | 38 | 54967 | 2023 | 63431994 |
| Haematemesis | 79.41 | 11.24 | 114 | 54891 | 30298 | 63403719 |
| Wound | 76.80 | 11.24 | 23 | 54982 | 163240 | 63270777 |
| Total lung capacity increased | 75.88 | 11.24 | 38 | 54967 | 2272 | 63431745 |
| Product use issue | 74.21 | 11.24 | 50 | 54955 | 220470 | 63213547 |
| Neutropenic sepsis | 74.08 | 11.24 | 81 | 54924 | 16357 | 63417660 |
| Arthralgia | 74.07 | 11.24 | 250 | 54755 | 569460 | 62864557 |
| Injection site pain | 73.70 | 11.24 | 12 | 54993 | 129788 | 63304229 |
| Hepatotoxicity | 73.09 | 11.24 | 122 | 54883 | 36919 | 63397098 |
| Skin candida | 71.94 | 11.24 | 33 | 54972 | 1622 | 63432395 |
| Abdominal discomfort | 70.07 | 11.24 | 106 | 54899 | 320779 | 63113238 |
| Therapeutic product effect incomplete | 63.77 | 11.24 | 15 | 54990 | 125041 | 63308976 |
| Hypersensitivity | 62.63 | 11.24 | 98 | 54907 | 292587 | 63141430 |
| Musculoskeletal stiffness | 61.91 | 11.24 | 42 | 54963 | 184576 | 63249441 |
| Heart sounds | 60.03 | 11.24 | 25 | 54980 | 971 | 63433046 |
| Dehydration | 58.66 | 11.24 | 301 | 54704 | 173053 | 63260964 |
| Prolonged expiration | 57.72 | 11.24 | 25 | 54980 | 1071 | 63432946 |
| Confusional state | 57.52 | 11.24 | 376 | 54629 | 236004 | 63198013 |
| Pericarditis | 55.88 | 11.24 | 22 | 54983 | 131557 | 63302460 |
| Nasopharyngitis | 55.47 | 11.24 | 84 | 54921 | 254173 | 63179844 |
| Lymphatic fistula | 55.14 | 11.24 | 22 | 54983 | 764 | 63433253 |
| General physical health deterioration | 55.00 | 11.24 | 330 | 54675 | 201072 | 63232945 |
| Vomiting | 54.96 | 11.24 | 732 | 54273 | 558885 | 62875132 |
| Femoral hernia incarcerated | 53.70 | 11.24 | 22 | 54983 | 819 | 63433198 |
| Wound infection pseudomonas | 53.12 | 11.24 | 25 | 54980 | 1303 | 63432714 |
| Psoriatic arthropathy | 52.99 | 11.24 | 8 | 54997 | 91512 | 63342505 |
| Intestinal pseudo-obstruction | 51.98 | 11.24 | 22 | 54983 | 890 | 63433127 |
| Rash | 51.41 | 11.24 | 281 | 54724 | 560590 | 62873427 |
| Fatigue | 49.88 | 11.24 | 511 | 54494 | 887517 | 62546500 |
| Pancreatic steatosis | 49.69 | 11.24 | 22 | 54983 | 994 | 63433023 |
| Helicobacter infection | 49.59 | 11.24 | 10 | 54995 | 92775 | 63341242 |
| Off label use | 49.45 | 11.24 | 362 | 54643 | 674100 | 62759917 |
| Jaundice | 49.44 | 11.24 | 90 | 54915 | 29161 | 63404856 |
| Urinary retention | 48.41 | 11.24 | 91 | 54914 | 30210 | 63403807 |
| Hypokalaemia | 48.30 | 11.24 | 198 | 54807 | 103606 | 63330411 |
| Abdominal pain | 46.85 | 11.24 | 423 | 54582 | 293033 | 63140984 |
| Hepatic failure | 46.07 | 11.24 | 98 | 54907 | 35558 | 63398459 |
| Multiple drug therapy | 45.26 | 11.24 | 32 | 54973 | 3614 | 63430403 |
| Sarcoidosis | 44.74 | 11.24 | 42 | 54963 | 7080 | 63426937 |
| Varices oesophageal | 44.67 | 11.24 | 30 | 54975 | 3118 | 63430899 |
| Nasal polyps | 44.58 | 11.24 | 39 | 54966 | 6000 | 63428017 |
| Haemarthrosis | 44.56 | 11.24 | 30 | 54975 | 3131 | 63430886 |
| Urticaria | 44.22 | 11.24 | 47 | 54958 | 165755 | 63268262 |
| Exposure during pregnancy | 43.88 | 11.24 | 42 | 54963 | 155505 | 63278512 |
| Irritable bowel syndrome | 43.80 | 11.24 | 9 | 54996 | 82403 | 63351614 |
| Neutrophil count increased | 43.21 | 11.24 | 62 | 54943 | 16465 | 63417552 |
| Blood cholesterol increased | 42.85 | 11.24 | 14 | 54991 | 94018 | 63339999 |
| Injection site erythema | 42.35 | 11.24 | 10 | 54995 | 83164 | 63350853 |
| Arterial haemorrhage | 41.47 | 11.24 | 23 | 54982 | 1694 | 63432323 |
| Hepatocellular carcinoma | 41.32 | 11.24 | 25 | 54980 | 2169 | 63431848 |
| Ill-defined disorder | 41.29 | 11.24 | 10 | 54995 | 81745 | 63352272 |
| Acute kidney injury | 41.16 | 11.24 | 378 | 54627 | 263037 | 63170980 |
| Weight increased | 39.85 | 11.24 | 106 | 54899 | 260686 | 63173331 |
| Encephalopathy | 39.74 | 11.24 | 97 | 54908 | 38523 | 63395494 |
| Chronic hepatic failure | 39.59 | 11.24 | 16 | 54989 | 575 | 63433442 |
| Seroma | 39.41 | 11.24 | 24 | 54981 | 2107 | 63431910 |
| Urinary tract infection | 36.99 | 11.24 | 371 | 54634 | 264313 | 63169704 |
| Arthritis | 36.72 | 11.24 | 28 | 54977 | 115893 | 63318124 |
| Ileus | 36.69 | 11.24 | 54 | 54951 | 14671 | 63419346 |
| Aortic arteriosclerosis | 35.94 | 11.24 | 35 | 54970 | 6174 | 63427843 |
| Dementia | 35.87 | 11.24 | 61 | 54944 | 18733 | 63415284 |
| Diverticulum intestinal | 35.45 | 11.24 | 36 | 54969 | 6677 | 63427340 |
| Anaemia | 34.36 | 11.24 | 397 | 54608 | 293033 | 63140984 |
| Therapeutic response decreased | 34.22 | 11.24 | 6 | 54999 | 61519 | 63372498 |
| Cardiac murmur | 32.90 | 11.24 | 51 | 54954 | 14501 | 63419516 |
| Infection | 32.88 | 11.24 | 96 | 54909 | 229077 | 63204940 |
| Urinary incontinence | 32.51 | 11.24 | 80 | 54925 | 31934 | 63402083 |
| Aortic valve stenosis | 32.08 | 11.24 | 25 | 54980 | 3274 | 63430743 |
| Gastrointestinal disorder | 31.96 | 11.24 | 40 | 54965 | 131199 | 63302818 |
| Type 2 diabetes mellitus | 31.88 | 11.24 | 8 | 54997 | 63860 | 63370157 |
| Psoriasis | 31.60 | 11.24 | 18 | 54987 | 86939 | 63347078 |
| Abdominal tenderness | 31.30 | 11.24 | 37 | 54968 | 8129 | 63425888 |
| Peritonitis bacterial | 31.08 | 11.24 | 29 | 54976 | 4850 | 63429167 |
| Intentional overdose | 30.50 | 11.24 | 13 | 54992 | 74139 | 63359878 |
| Headache | 30.46 | 11.24 | 377 | 54628 | 632864 | 62801153 |
| Hip arthroplasty | 30.43 | 11.24 | 3 | 55002 | 47643 | 63386374 |
| White blood cell count increased | 29.55 | 11.24 | 101 | 54904 | 48460 | 63385557 |
| Duodenal ulcer | 29.49 | 11.24 | 35 | 54970 | 7721 | 63426296 |
| Depressive symptom | 29.30 | 11.24 | 26 | 54979 | 4076 | 63429941 |
| Wound dehiscence | 29.06 | 11.24 | 28 | 54977 | 4875 | 63429142 |
| Cirrhosis alcoholic | 28.86 | 11.24 | 10 | 54995 | 232 | 63433785 |
| Oesophageal varices haemorrhage | 28.36 | 11.24 | 16 | 54989 | 1218 | 63432799 |
| Alkalosis hypochloraemic | 28.32 | 11.24 | 9 | 54996 | 158 | 63433859 |
| Product dose omission issue | 28.21 | 11.24 | 106 | 54899 | 234207 | 63199810 |
| Delirium | 28.07 | 11.24 | 102 | 54903 | 50439 | 63383578 |
| Nail dystrophy | 28.05 | 11.24 | 15 | 54990 | 1028 | 63432989 |
| Hepatic cyst | 27.88 | 11.24 | 28 | 54977 | 5126 | 63428891 |
| Melaena | 27.83 | 11.24 | 73 | 54932 | 30292 | 63403725 |
| Mucosal inflammation | 27.17 | 11.24 | 96 | 54909 | 46832 | 63387185 |
| Portal hypertension | 26.87 | 11.24 | 24 | 54981 | 3795 | 63430222 |
| Hypertriglyceridaemia | 26.75 | 11.24 | 30 | 54975 | 6229 | 63427788 |
| C-reactive protein abnormal | 26.74 | 11.24 | 4 | 55001 | 46092 | 63387925 |
| Disturbance in attention | 26.45 | 11.24 | 83 | 54922 | 38106 | 63395911 |
| Seizure | 26.37 | 11.24 | 201 | 54804 | 132433 | 63301584 |
| Injection site reaction | 26.16 | 11.24 | 9 | 54996 | 58515 | 63375502 |
| Respiration abnormal | 26.14 | 11.24 | 30 | 54975 | 6387 | 63427630 |
| Cholestasis of pregnancy | 25.79 | 11.24 | 15 | 54990 | 1210 | 63432807 |
| Thrombocytopenia | 25.68 | 11.24 | 221 | 54784 | 150936 | 63283081 |
| Abdominal distension | 25.60 | 11.24 | 145 | 54860 | 86470 | 63347547 |
| Tachyarrhythmia | 25.60 | 11.24 | 25 | 54980 | 4425 | 63429592 |
| Sepsis | 25.56 | 11.24 | 223 | 54782 | 152900 | 63281117 |
| Dermatitis bullous | 25.36 | 11.24 | 34 | 54971 | 8474 | 63425543 |
| Hyperammonaemic encephalopathy | 24.88 | 11.24 | 19 | 54986 | 2415 | 63431602 |
| Disorientation | 24.84 | 11.24 | 83 | 54922 | 39369 | 63394648 |
| Pneumonia | 24.72 | 11.24 | 543 | 54462 | 456224 | 62977793 |
| Cardiospasm | 24.28 | 11.24 | 17 | 54988 | 1890 | 63432127 |
| Lung neoplasm malignant | 24.26 | 11.24 | 53 | 54952 | 19580 | 63414437 |
| Intestinal obstruction | 24.07 | 11.24 | 70 | 54935 | 30829 | 63403188 |
| Hyperammonaemia | 23.95 | 11.24 | 26 | 54979 | 5206 | 63428811 |
| Haemoglobin decreased | 23.82 | 11.24 | 211 | 54794 | 145274 | 63288743 |
| Injection site pruritus | 23.82 | 11.24 | 5 | 55000 | 45111 | 63388906 |
| Superinfection | 23.73 | 11.24 | 19 | 54986 | 2588 | 63431429 |
| Rhinitis allergic | 23.63 | 11.24 | 39 | 54966 | 11688 | 63422329 |
| Hypernatraemia | 23.59 | 11.24 | 31 | 54974 | 7578 | 63426439 |
| Palmoplantar keratoderma | 23.50 | 11.24 | 17 | 54988 | 1990 | 63432027 |
| Intestinal dilatation | 23.46 | 11.24 | 16 | 54989 | 1706 | 63432311 |
| Pruritus genital | 23.43 | 11.24 | 19 | 54986 | 2635 | 63431382 |
| Abortion spontaneous | 23.39 | 11.24 | 6 | 54999 | 47189 | 63386828 |
| Oedema peripheral | 23.33 | 11.24 | 259 | 54746 | 189252 | 63244765 |
| Peripheral swelling | 23.32 | 11.24 | 135 | 54870 | 265807 | 63168210 |
| Mouth ulceration | 23.13 | 11.24 | 72 | 54933 | 32912 | 63401105 |
| Adverse event | 23.13 | 11.24 | 15 | 54990 | 67544 | 63366473 |
| Hypoaesthesia | 23.10 | 11.24 | 72 | 54933 | 168321 | 63265696 |
| Hiatus hernia | 23.03 | 11.24 | 55 | 54950 | 21539 | 63412478 |
| Portal hypertensive gastropathy | 23.03 | 11.24 | 12 | 54993 | 780 | 63433237 |
| Suicide attempt | 23.02 | 11.24 | 12 | 54993 | 60906 | 63373111 |
| Left ventricular dysfunction | 22.99 | 11.24 | 39 | 54966 | 11949 | 63422068 |
| Body mass index decreased | 22.75 | 11.24 | 10 | 54995 | 444 | 63433573 |
| Blood pressure increased | 22.43 | 11.24 | 69 | 54936 | 161993 | 63272024 |
| Inflammation | 22.29 | 11.24 | 23 | 54982 | 82250 | 63351767 |
| Insurance issue | 22.25 | 11.24 | 27 | 54978 | 6094 | 63427923 |
| Depressed mood | 22.22 | 11.24 | 81 | 54924 | 40110 | 63393907 |
| Gastrointestinal haemorrhage | 22.11 | 11.24 | 133 | 54872 | 81043 | 63352974 |
| Therapy non-responder | 21.97 | 11.24 | 20 | 54985 | 75881 | 63358136 |
| Lip swelling | 21.96 | 11.24 | 68 | 54937 | 30995 | 63403022 |
| Product prescribing error | 21.88 | 11.24 | 61 | 54944 | 26228 | 63407789 |
| Appetite disorder | 21.43 | 11.24 | 29 | 54976 | 7292 | 63426725 |
| Axillary pain | 21.42 | 11.24 | 16 | 54989 | 1967 | 63432050 |
| Injection site bruising | 21.41 | 11.24 | 5 | 55000 | 41905 | 63392112 |
| Upper gastrointestinal haemorrhage | 21.18 | 11.24 | 49 | 54956 | 18803 | 63415214 |
| Blood albumin abnormal | 21.11 | 11.24 | 10 | 54995 | 529 | 63433488 |
| Pain in extremity | 20.92 | 11.24 | 185 | 54820 | 331301 | 63102716 |
| Monocyte count increased | 20.90 | 11.24 | 29 | 54976 | 7464 | 63426553 |
| Femoral neck fracture | 20.86 | 11.24 | 31 | 54974 | 8492 | 63425525 |
| Mouth swelling | 20.74 | 11.24 | 23 | 54982 | 4717 | 63429300 |
| Hepatitis C | 20.38 | 11.24 | 24 | 54981 | 5250 | 63428767 |
| Device expulsion | 20.33 | 11.24 | 3 | 55002 | 34919 | 63399098 |
| Spinal cord paralysis | 20.28 | 11.24 | 5 | 55000 | 32 | 63433985 |
| Death | 20.21 | 11.24 | 445 | 54560 | 373936 | 63060081 |
| Inappropriate schedule of product administration | 20.18 | 11.24 | 37 | 54968 | 103928 | 63330089 |
| Flail chest | 20.14 | 11.24 | 6 | 54999 | 84 | 63433933 |
| Fibromyalgia | 20.11 | 11.24 | 24 | 54981 | 80396 | 63353621 |
| Eructation | 19.96 | 11.24 | 30 | 54975 | 8303 | 63425714 |
| Product monitoring error | 19.91 | 11.24 | 22 | 54983 | 4494 | 63429523 |
| Pancytopenia | 19.88 | 11.24 | 148 | 54857 | 96785 | 63337232 |
| Vascular encephalopathy | 19.82 | 11.24 | 9 | 54996 | 432 | 63433585 |
| Hallucination | 19.79 | 11.24 | 97 | 54908 | 54720 | 63379297 |
| Lung perforation | 19.63 | 11.24 | 6 | 54999 | 92 | 63433925 |
| Intentional product use issue | 19.50 | 11.24 | 52 | 54953 | 127840 | 63306177 |
| Toxic epidermal necrolysis | 19.36 | 11.24 | 57 | 54948 | 25277 | 63408740 |
| Pruritus | 19.34 | 11.24 | 210 | 54795 | 361243 | 63072774 |
| Bradycardia | 19.32 | 11.24 | 119 | 54886 | 73108 | 63360909 |
| Bronchiectasis | 19.29 | 11.24 | 43 | 54962 | 16099 | 63417918 |
| Drug interaction | 19.28 | 11.24 | 292 | 54713 | 228839 | 63205178 |
| Herpes zoster | 19.18 | 11.24 | 26 | 54979 | 82436 | 63351581 |
| Sleep terror | 19.17 | 11.24 | 17 | 54988 | 2663 | 63431354 |
| Abdominal rigidity | 18.95 | 11.24 | 15 | 54990 | 2009 | 63432008 |
| Pulmonary vein occlusion | 18.90 | 11.24 | 6 | 54999 | 105 | 63433912 |
| Pneumatosis intestinalis | 18.66 | 11.24 | 16 | 54989 | 2397 | 63431620 |
| Anuria | 17.98 | 11.24 | 36 | 54969 | 12515 | 63421502 |
| Ejection fraction decreased | 17.79 | 11.24 | 51 | 54954 | 22281 | 63411736 |
| Muscle twitching | 17.73 | 11.24 | 47 | 54958 | 19621 | 63414396 |
| Cholestasis | 17.71 | 11.24 | 61 | 54944 | 29373 | 63404644 |
| Hypomagnesaemia | 17.68 | 11.24 | 60 | 54945 | 28677 | 63405340 |
| Hiccups | 17.67 | 11.24 | 15 | 54990 | 2216 | 63431801 |
| Red blood cell sedimentation rate increased | 17.63 | 11.24 | 8 | 54997 | 43974 | 63390043 |
| Prescribed overdose | 17.59 | 11.24 | 4 | 55001 | 34149 | 63399868 |
| Hallucination, visual | 17.28 | 11.24 | 46 | 54959 | 19252 | 63414765 |
| Salivary gland enlargement | 17.22 | 11.24 | 8 | 54997 | 405 | 63433612 |
| Therapeutic drug monitoring analysis not performed | 17.09 | 11.24 | 12 | 54993 | 1340 | 63432677 |
| Osteoarthritis | 16.72 | 11.24 | 36 | 54969 | 95307 | 63338710 |
| Bronchitis | 16.72 | 11.24 | 54 | 54951 | 124881 | 63309136 |
| Chronic obstructive pulmonary disease | 16.62 | 11.24 | 102 | 54903 | 62584 | 63371433 |
| Syncope | 16.58 | 11.24 | 165 | 54840 | 117220 | 63316797 |
| Hyperglycaemia | 16.50 | 11.24 | 76 | 54929 | 41791 | 63392226 |
| Liver function test abnormal | 16.50 | 11.24 | 84 | 54921 | 48097 | 63385920 |
| Postoperative wound infection | 16.45 | 11.24 | 32 | 54973 | 10893 | 63423124 |
| Escherichia infection | 16.41 | 11.24 | 35 | 54970 | 12719 | 63421298 |
| Thoracic operation | 16.32 | 11.24 | 6 | 54999 | 166 | 63433851 |
| Blister | 16.09 | 11.24 | 58 | 54947 | 129756 | 63304261 |
| Nervous system disorder | 16.07 | 11.24 | 44 | 54961 | 18722 | 63415295 |
| Lethargy | 16.04 | 11.24 | 93 | 54912 | 55914 | 63378103 |
| Tension headache | 15.88 | 11.24 | 21 | 54984 | 5165 | 63428852 |
| Cardiovascular disorder | 15.88 | 11.24 | 33 | 54972 | 11779 | 63422238 |
| Hypertension | 15.85 | 11.24 | 160 | 54845 | 279143 | 63154874 |
| Functional gastrointestinal disorder | 15.83 | 11.24 | 19 | 54986 | 4240 | 63429777 |
| Aplastic anaemia | 15.61 | 11.24 | 29 | 54976 | 9540 | 63424477 |
| Blood alkaline phosphatase increased | 15.48 | 11.24 | 76 | 54929 | 42891 | 63391126 |
| Electrocardiogram T wave inversion | 15.42 | 11.24 | 17 | 54988 | 3464 | 63430553 |
| Rales | 15.37 | 11.24 | 34 | 54971 | 12663 | 63421354 |
| Hepatorenal syndrome | 15.32 | 11.24 | 13 | 54992 | 1919 | 63432098 |
| Stevens-Johnson syndrome | 15.27 | 11.24 | 52 | 54953 | 24898 | 63409119 |
| Oral contusion | 15.27 | 11.24 | 5 | 55000 | 97 | 63433920 |
| Stomatitis | 15.26 | 11.24 | 65 | 54940 | 138660 | 63295357 |
| Haematocrit increased | 15.15 | 11.24 | 14 | 54991 | 2312 | 63431705 |
| Frostbite | 14.99 | 11.24 | 5 | 55000 | 103 | 63433914 |
| Tumour hyperprogression | 14.94 | 11.24 | 5 | 55000 | 104 | 63433913 |
| Alkalosis | 14.89 | 11.24 | 7 | 54998 | 364 | 63433653 |
| Plasma cell myeloma | 14.77 | 11.24 | 66 | 54939 | 35839 | 63398178 |
| Circulatory collapse | 14.57 | 11.24 | 47 | 54958 | 21891 | 63412126 |
| Asterixis | 14.47 | 11.24 | 11 | 54994 | 1388 | 63432629 |
| Neutropenia | 14.31 | 11.24 | 222 | 54783 | 174783 | 63259234 |
| Aspiration | 14.22 | 11.24 | 30 | 54975 | 10821 | 63423196 |
| Joint injury | 14.20 | 11.24 | 4 | 55001 | 29568 | 63404449 |
| Nail infection | 14.19 | 11.24 | 14 | 54991 | 2509 | 63431508 |
| Febrile neutropenia | 14.16 | 11.24 | 161 | 54844 | 118288 | 63315729 |
| Cardiac ventricular thrombosis | 14.16 | 11.24 | 8 | 54997 | 611 | 63433406 |
| Liver injury | 14.16 | 11.24 | 19 | 54986 | 60501 | 63373516 |
| Foetal exposure during pregnancy | 14.14 | 11.24 | 5 | 55000 | 31957 | 63402060 |
| Inflammatory marker increased | 14.12 | 11.24 | 23 | 54982 | 6816 | 63427201 |
| Activated partial thromboplastin time abnormal | 14.08 | 11.24 | 5 | 55000 | 125 | 63433892 |
| Adverse drug reaction | 14.06 | 11.24 | 30 | 54975 | 79684 | 63354333 |
| Thrombocytosis | 14.01 | 11.24 | 21 | 54984 | 5797 | 63428220 |
| Vascular parkinsonism | 14.00 | 11.24 | 5 | 55000 | 127 | 63433890 |
| Cardiomyopathy acute | 13.85 | 11.24 | 6 | 54999 | 257 | 63433760 |
| Spinal cord infarction | 13.83 | 11.24 | 6 | 54999 | 258 | 63433759 |
| Ear infection | 13.75 | 11.24 | 8 | 54997 | 38205 | 63395812 |
| Immunisation | 13.73 | 11.24 | 10 | 54995 | 1183 | 63432834 |
| Physical assault | 13.59 | 11.24 | 9 | 54996 | 914 | 63433103 |
| Portopulmonary hypertension | 13.58 | 11.24 | 5 | 55000 | 139 | 63433878 |
| Gamma-glutamyltransferase increased | 13.58 | 11.24 | 62 | 54943 | 33969 | 63400048 |
| Colitis ulcerative | 13.55 | 11.24 | 3 | 55002 | 26088 | 63407929 |
| Spinal subdural haematoma | 13.48 | 11.24 | 5 | 55000 | 142 | 63433875 |
| Salivary hypersecretion | 13.48 | 11.24 | 24 | 54981 | 7642 | 63426375 |
| Impaired healing | 13.25 | 11.24 | 45 | 54960 | 102497 | 63331520 |
| Tricuspid valve incompetence | 13.24 | 11.24 | 35 | 54970 | 14586 | 63419431 |
| Neutrophil count decreased | 13.24 | 11.24 | 89 | 54916 | 56317 | 63377700 |
| Mechanical urticaria | 13.24 | 11.24 | 7 | 54998 | 469 | 63433548 |
| Subileus | 13.18 | 11.24 | 15 | 54990 | 3164 | 63430853 |
| Haemoglobin increased | 13.12 | 11.24 | 16 | 54989 | 3630 | 63430387 |
| Blood pressure systolic increased | 13.12 | 11.24 | 13 | 54992 | 47384 | 63386633 |
| Blood albumin decreased | 13.02 | 11.24 | 35 | 54970 | 14731 | 63419286 |
| Mutism | 12.99 | 11.24 | 11 | 54994 | 1619 | 63432398 |
| Pregnancy | 12.85 | 11.24 | 8 | 54997 | 36828 | 63397189 |
| Atrial tachycardia | 12.72 | 11.24 | 17 | 54988 | 4223 | 63429794 |
| Contusion | 12.70 | 11.24 | 77 | 54928 | 149967 | 63284050 |
| Pustule | 12.60 | 11.24 | 11 | 54994 | 1688 | 63432329 |
| Oropharyngeal pain | 12.53 | 11.24 | 41 | 54964 | 94446 | 63339571 |
| Appendicitis | 12.26 | 11.24 | 24 | 54981 | 8205 | 63425812 |
| Product administration error | 12.26 | 11.24 | 45 | 54960 | 22352 | 63411665 |
| Antipsychotic drug level increased | 12.24 | 11.24 | 15 | 54990 | 3420 | 63430597 |
| Sinus arrhythmia | 11.86 | 11.24 | 10 | 54995 | 1463 | 63432554 |
| Pickwickian syndrome | 11.85 | 11.24 | 6 | 54999 | 367 | 63433650 |
| Cardiac disorder | 11.84 | 11.24 | 16 | 54989 | 50800 | 63383217 |
| Chronotropic incompetence | 11.83 | 11.24 | 4 | 55001 | 86 | 63433931 |
| Multiple organ dysfunction syndrome | 11.83 | 11.24 | 87 | 54918 | 56665 | 63377352 |
| Dyskinesia | 11.81 | 11.24 | 57 | 54948 | 31945 | 63402072 |
| Gastrointestinal sounds abnormal | 11.78 | 11.24 | 16 | 54989 | 4035 | 63429982 |
| Jugular vein thrombosis | 11.74 | 11.24 | 14 | 54991 | 3104 | 63430913 |
| Vascular device infection | 11.73 | 11.24 | 22 | 54983 | 7290 | 63426727 |
| Flank pain | 11.67 | 11.24 | 36 | 54969 | 16374 | 63417643 |
| Mental status changes | 11.50 | 11.24 | 66 | 54939 | 39533 | 63394484 |
| Product selection error | 11.50 | 11.24 | 4 | 55001 | 94 | 63433923 |
| Hepatic hydrothorax | 11.48 | 11.24 | 3 | 55002 | 25 | 63433992 |
| Road traffic accident | 11.40 | 11.24 | 9 | 54996 | 36623 | 63397394 |
| Premature delivery | 11.39 | 11.24 | 6 | 54999 | 30275 | 63403742 |
| Carotid artery occlusion | 11.39 | 11.24 | 17 | 54988 | 4677 | 63429340 |
| Skin abrasion | 11.32 | 11.24 | 25 | 54980 | 9304 | 63424713 |
| Anticonvulsant drug level below therapeutic | 11.31 | 11.24 | 7 | 54998 | 632 | 63433385 |
| Fracture | 11.28 | 11.24 | 40 | 54965 | 19544 | 63414473 |
| Sciatica | 11.24 | 11.24 | 8 | 54997 | 34316 | 63399701 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hepatic encephalopathy | 688.55 | 11.03 | 352 | 45867 | 14333 | 34896379 |
| Hepatic cirrhosis | 182.04 | 11.03 | 164 | 46055 | 17150 | 34893562 |
| Confusional state | 158.57 | 11.03 | 484 | 45735 | 143676 | 34767036 |
| Hepatic failure | 147.31 | 11.03 | 204 | 46015 | 34327 | 34876385 |
| Inability to afford medication | 140.94 | 11.03 | 58 | 46161 | 1412 | 34909300 |
| Ammonia increased | 136.09 | 11.03 | 80 | 46139 | 4289 | 34906423 |
| Ascites | 132.35 | 11.03 | 228 | 45991 | 46343 | 34864369 |
| Drug ineffective | 121.05 | 11.03 | 266 | 45953 | 456485 | 34454227 |
| Constipation | 83.89 | 11.03 | 381 | 45838 | 136601 | 34774111 |
| Hepatorenal syndrome | 78.29 | 11.03 | 47 | 46172 | 2619 | 34908093 |
| Varices oesophageal | 77.49 | 11.03 | 53 | 46166 | 3702 | 34907010 |
| Drug abuse | 77.43 | 11.03 | 18 | 46201 | 99078 | 34811634 |
| Completed suicide | 74.42 | 11.03 | 19 | 46200 | 98149 | 34812563 |
| Toxic epidermal necrolysis | 73.65 | 11.03 | 115 | 46104 | 21531 | 34889181 |
| Hepatocellular carcinoma | 68.99 | 11.03 | 66 | 46153 | 7443 | 34903269 |
| General physical health deterioration | 68.50 | 11.03 | 343 | 45876 | 127926 | 34782786 |
| Off label use | 62.65 | 11.03 | 314 | 45905 | 419210 | 34491502 |
| Faecaloma | 62.62 | 11.03 | 54 | 46165 | 5323 | 34905389 |
| Encephalopathy | 57.24 | 11.03 | 137 | 46082 | 35182 | 34875530 |
| Pneumatosis intestinalis | 53.15 | 11.03 | 43 | 46176 | 3880 | 34906832 |
| Peritonitis bacterial | 52.93 | 11.03 | 52 | 46167 | 6058 | 34904654 |
| Oesophageal varices haemorrhage | 52.46 | 11.03 | 39 | 46180 | 3107 | 34907605 |
| Blood bilirubin increased | 52.09 | 11.03 | 139 | 46080 | 38157 | 34872555 |
| Hyperammonaemia | 51.12 | 11.03 | 52 | 46167 | 6315 | 34904397 |
| Abdominal pain | 49.01 | 11.03 | 377 | 45842 | 163241 | 34747471 |
| Arthralgia | 46.46 | 11.03 | 97 | 46122 | 169944 | 34740768 |
| Gastric varices | 46.26 | 11.03 | 20 | 46199 | 552 | 34910160 |
| Insurance issue | 44.99 | 11.03 | 30 | 46189 | 2009 | 34908703 |
| Chronic hepatic failure | 44.97 | 11.03 | 19 | 46200 | 495 | 34910217 |
| Hyponatraemia | 44.71 | 11.03 | 222 | 45997 | 82469 | 34828243 |
| Abdominal distension | 44.53 | 11.03 | 174 | 46045 | 58318 | 34852394 |
| Haematemesis | 43.30 | 11.03 | 106 | 46113 | 27605 | 34883107 |
| Portal hypertension | 41.73 | 11.03 | 38 | 46181 | 4024 | 34906688 |
| Jaundice | 41.63 | 11.03 | 114 | 46105 | 31768 | 34878944 |
| Alveolar lung disease | 39.64 | 11.03 | 16 | 46203 | 370 | 34910342 |
| Hepatitis C | 35.93 | 11.03 | 54 | 46165 | 9776 | 34900936 |
| Pulmonary interstitial emphysema syndrome | 34.93 | 11.03 | 16 | 46203 | 508 | 34910204 |
| Antipsychotic drug level increased | 33.67 | 11.03 | 33 | 46186 | 3832 | 34906880 |
| Cirrhosis alcoholic | 33.21 | 11.03 | 18 | 46201 | 824 | 34909888 |
| Liver transplant | 32.70 | 11.03 | 27 | 46192 | 2507 | 34908205 |
| Pyramidal tract syndrome | 32.41 | 11.03 | 12 | 46207 | 218 | 34910494 |
| Toxicity to various agents | 32.08 | 11.03 | 146 | 46073 | 200216 | 34710496 |
| Rash | 31.82 | 11.03 | 169 | 46050 | 222583 | 34688129 |
| Injection site pain | 30.61 | 11.03 | 7 | 46212 | 38998 | 34871714 |
| High-grade B-cell lymphoma | 30.44 | 11.03 | 10 | 46209 | 125 | 34910587 |
| Stoma site erythema | 30.25 | 11.03 | 17 | 46202 | 836 | 34909876 |
| Periarthritis calcarea | 29.96 | 11.03 | 9 | 46210 | 82 | 34910630 |
| Benign gastrointestinal neoplasm | 29.74 | 11.03 | 10 | 46209 | 135 | 34910577 |
| Articular calcification | 29.67 | 11.03 | 9 | 46210 | 85 | 34910627 |
| Stoma site discharge | 29.58 | 11.03 | 19 | 46200 | 1194 | 34909518 |
| On and off phenomenon | 28.92 | 11.03 | 25 | 46194 | 2472 | 34908240 |
| Systemic infection | 28.78 | 11.03 | 35 | 46184 | 5177 | 34905535 |
| Product use in unapproved indication | 28.06 | 11.03 | 72 | 46147 | 117427 | 34793285 |
| Ileus | 27.80 | 11.03 | 65 | 46154 | 16434 | 34894278 |
| Neutrophil count increased | 27.22 | 11.03 | 66 | 46153 | 17080 | 34893632 |
| Portal hypertensive gastropathy | 26.40 | 11.03 | 14 | 46205 | 613 | 34910099 |
| Immature granulocyte count increased | 26.14 | 11.03 | 9 | 46210 | 131 | 34910581 |
| Acute kidney injury | 26.10 | 11.03 | 556 | 45663 | 304432 | 34606280 |
| Rheumatoid arthritis | 26.04 | 11.03 | 9 | 46210 | 38229 | 34872483 |
| Fall | 25.89 | 11.03 | 394 | 45825 | 202491 | 34708221 |
| Product dose omission issue | 25.87 | 11.03 | 77 | 46142 | 119634 | 34791078 |
| Pneumonia | 25.47 | 11.03 | 643 | 45576 | 361984 | 34548728 |
| Myocardial infarction | 25.37 | 11.03 | 79 | 46140 | 121006 | 34789706 |
| Adrenal cyst | 24.80 | 11.03 | 9 | 46210 | 154 | 34910558 |
| Conjunctival irritation | 24.28 | 11.03 | 8 | 46211 | 101 | 34910611 |
| Hypermagnesaemia | 24.27 | 11.03 | 10 | 46209 | 244 | 34910468 |
| Joint swelling | 24.26 | 11.03 | 26 | 46193 | 59864 | 34850848 |
| Foetal exposure during pregnancy | 24.22 | 11.03 | 10 | 46209 | 38091 | 34872621 |
| Inappropriate schedule of product administration | 24.19 | 11.03 | 28 | 46191 | 62268 | 34848444 |
| Therapeutic product effect incomplete | 23.95 | 11.03 | 19 | 46200 | 50522 | 34860190 |
| Myalgia | 23.77 | 11.03 | 47 | 46172 | 84063 | 34826649 |
| Hypernatraemia | 23.35 | 11.03 | 41 | 46178 | 8449 | 34902263 |
| Intentional product use issue | 23.10 | 11.03 | 27 | 46192 | 59789 | 34850923 |
| Treatment failure | 22.84 | 11.03 | 17 | 46202 | 46680 | 34864032 |
| Atrial fibrillation | 22.81 | 11.03 | 84 | 46135 | 122309 | 34788403 |
| Nasopharyngitis | 22.57 | 11.03 | 36 | 46183 | 69932 | 34840780 |
| Cardiac failure congestive | 22.29 | 11.03 | 48 | 46171 | 83222 | 34827490 |
| Asterixis | 22.17 | 11.03 | 16 | 46203 | 1217 | 34909495 |
| Urinary tract infection | 22.01 | 11.03 | 188 | 46031 | 83893 | 34826819 |
| Polypectomy | 21.97 | 11.03 | 12 | 46207 | 558 | 34910154 |
| White blood cell count increased | 21.88 | 11.03 | 110 | 46109 | 41041 | 34869671 |
| Neutropenic sepsis | 21.86 | 11.03 | 53 | 46166 | 13714 | 34896998 |
| Mesothelioma | 21.80 | 11.03 | 11 | 46208 | 434 | 34910278 |
| Drug resistance | 21.70 | 11.03 | 4 | 46215 | 25923 | 34884789 |
| Acute abdomen | 21.49 | 11.03 | 19 | 46200 | 1936 | 34908776 |
| Mental status changes | 21.10 | 11.03 | 103 | 46116 | 37980 | 34872732 |
| Haemoglobin decreased | 20.95 | 11.03 | 248 | 45971 | 120524 | 34790188 |
| Pneumonia aspiration | 20.88 | 11.03 | 110 | 46109 | 41793 | 34868919 |
| Lower respiratory tract infection | 20.81 | 11.03 | 90 | 46129 | 31547 | 34879165 |
| Activated partial thromboplastin time shortened | 20.74 | 11.03 | 11 | 46208 | 482 | 34910230 |
| Hepatitis C RNA positive | 20.45 | 11.03 | 8 | 46211 | 170 | 34910542 |
| Metamyelocyte count increased | 20.26 | 11.03 | 10 | 46209 | 376 | 34910336 |
| Wrong patient received product | 20.09 | 11.03 | 21 | 46198 | 2633 | 34908079 |
| Vomiting | 19.43 | 11.03 | 446 | 45773 | 247175 | 34663537 |
| Urinary retention | 19.29 | 11.03 | 97 | 46122 | 36191 | 34874521 |
| Spleen congestion | 19.08 | 11.03 | 9 | 46210 | 306 | 34910406 |
| Freezing phenomenon | 19.06 | 11.03 | 16 | 46203 | 1520 | 34909192 |
| Asthma | 19.03 | 11.03 | 17 | 46202 | 42639 | 34868073 |
| Delirium | 18.93 | 11.03 | 111 | 46108 | 43880 | 34866832 |
| Epilepsy | 18.90 | 11.03 | 67 | 46152 | 21428 | 34889284 |
| Blood pressure increased | 18.79 | 11.03 | 57 | 46162 | 88045 | 34822667 |
| Hypophagia | 18.71 | 11.03 | 72 | 46147 | 23950 | 34886762 |
| Liver function test abnormal | 18.64 | 11.03 | 86 | 46133 | 30988 | 34879724 |
| Hepatic calcification | 18.25 | 11.03 | 9 | 46210 | 338 | 34910374 |
| Hypersensitivity | 18.21 | 11.03 | 33 | 46186 | 61002 | 34849710 |
| Adrenal adenoma | 18.05 | 11.03 | 10 | 46209 | 478 | 34910234 |
| Dehydration | 17.96 | 11.03 | 256 | 45963 | 129713 | 34780999 |
| Therapeutic product effect decreased | 17.84 | 11.03 | 12 | 46207 | 34731 | 34875981 |
| Myelocyte count increased | 17.77 | 11.03 | 9 | 46210 | 358 | 34910354 |
| Adrenomegaly | 17.72 | 11.03 | 9 | 46210 | 360 | 34910352 |
| Costal cartilage fracture | 17.70 | 11.03 | 8 | 46211 | 246 | 34910466 |
| Ureaplasma infection | 17.68 | 11.03 | 9 | 46210 | 362 | 34910350 |
| Dysphagia | 17.66 | 11.03 | 142 | 46077 | 62239 | 34848473 |
| Rectal haemorrhage | 17.60 | 11.03 | 102 | 46117 | 40147 | 34870565 |
| Genital erythema | 17.29 | 11.03 | 8 | 46211 | 260 | 34910452 |
| Arthritis | 17.24 | 11.03 | 10 | 46209 | 31336 | 34879376 |
| Intentional product misuse | 17.17 | 11.03 | 21 | 46198 | 45590 | 34865122 |
| Interstitial lung disease | 17.16 | 11.03 | 38 | 46181 | 65244 | 34845468 |
| Portal vein thrombosis | 17.07 | 11.03 | 23 | 46196 | 3765 | 34906947 |
| Therapy interrupted | 16.91 | 11.03 | 48 | 46171 | 13649 | 34897063 |
| Psoriatic arthropathy | 16.68 | 11.03 | 3 | 46216 | 19795 | 34890917 |
| Coronary artery disease | 16.39 | 11.03 | 24 | 46195 | 48281 | 34862431 |
| Upper gastrointestinal haemorrhage | 16.33 | 11.03 | 72 | 46147 | 25446 | 34885266 |
| Colitis ischaemic | 16.19 | 11.03 | 30 | 46189 | 6445 | 34904267 |
| COVID-19 | 15.95 | 11.03 | 51 | 46168 | 77499 | 34833213 |
| Orthostatic hypotension | 15.74 | 11.03 | 72 | 46147 | 25847 | 34884865 |
| Differential white blood cell count abnormal | 15.68 | 11.03 | 14 | 46205 | 1445 | 34909267 |
| Portal shunt procedure | 15.55 | 11.03 | 4 | 46215 | 19 | 34910693 |
| Activated partial thromboplastin time prolonged | 15.47 | 11.03 | 35 | 46184 | 8660 | 34902052 |
| Nephrocalcinosis | 15.43 | 11.03 | 10 | 46209 | 638 | 34910074 |
| Eosinophilic pneumonia | 15.39 | 11.03 | 21 | 46198 | 3480 | 34907232 |
| Venous thrombosis limb | 15.32 | 11.03 | 16 | 46203 | 2003 | 34908709 |
| Diffuse alveolar damage | 15.22 | 11.03 | 17 | 46202 | 2297 | 34908415 |
| Blast cells present | 15.11 | 11.03 | 9 | 46210 | 494 | 34910218 |
| Disorientation | 15.10 | 11.03 | 85 | 46134 | 33103 | 34877609 |
| Peripheral artery stenosis | 14.97 | 11.03 | 11 | 46208 | 861 | 34909851 |
| Ischaemic hepatitis | 14.80 | 11.03 | 15 | 46204 | 1813 | 34908899 |
| Lethargy | 14.72 | 11.03 | 99 | 46120 | 41023 | 34869689 |
| Sepsis | 14.63 | 11.03 | 305 | 45914 | 166256 | 34744456 |
| Abdominal tenderness | 14.44 | 11.03 | 22 | 46197 | 4029 | 34906683 |
| Melaena | 14.41 | 11.03 | 88 | 46131 | 35292 | 34875420 |
| Hepatic cancer | 14.38 | 11.03 | 33 | 46186 | 8242 | 34902470 |
| Peritonitis | 14.37 | 11.03 | 51 | 46168 | 16314 | 34894398 |
| Weight | 14.36 | 11.03 | 4 | 46215 | 27 | 34910685 |
| Portal tract inflammation | 14.33 | 11.03 | 5 | 46214 | 76 | 34910636 |
| Platelet count decreased | 14.29 | 11.03 | 230 | 45989 | 119487 | 34791225 |
| Hypertension | 14.13 | 11.03 | 114 | 46105 | 136329 | 34774383 |
| Hyperkalaemia | 14.08 | 11.03 | 147 | 46072 | 69242 | 34841470 |
| Headache | 14.03 | 11.03 | 184 | 46035 | 200451 | 34710261 |
| Arteriosclerosis coronary artery | 13.74 | 11.03 | 42 | 46177 | 12443 | 34898269 |
| Salivary gland disorder | 13.73 | 11.03 | 6 | 46213 | 170 | 34910542 |
| Monocyte count decreased | 13.65 | 11.03 | 12 | 46207 | 1214 | 34909498 |
| Paracentesis | 13.55 | 11.03 | 8 | 46211 | 432 | 34910280 |
| Vascular purpura | 13.33 | 11.03 | 14 | 46205 | 1764 | 34908948 |
| Wrong technique in product usage process | 13.09 | 11.03 | 17 | 46202 | 35969 | 34874743 |
| Spinal cord injury thoracic | 13.06 | 11.03 | 5 | 46214 | 100 | 34910612 |
| Myoclonus | 13.03 | 11.03 | 46 | 46173 | 14679 | 34896033 |
| Anaemia | 13.01 | 11.03 | 402 | 45817 | 232933 | 34677779 |
| Coma hepatic | 12.99 | 11.03 | 8 | 46211 | 467 | 34910245 |
| Portal shunt | 12.98 | 11.03 | 4 | 46215 | 40 | 34910672 |
| Influenza | 12.98 | 11.03 | 29 | 46190 | 49637 | 34861075 |
| Arthropathy | 12.89 | 11.03 | 10 | 46209 | 26897 | 34883815 |
| Gastrointestinal tract mucosal pigmentation | 12.76 | 11.03 | 8 | 46211 | 482 | 34910230 |
| Rash vesicular | 12.73 | 11.03 | 17 | 46202 | 2760 | 34907952 |
| Adrenocortical insufficiency acute | 12.72 | 11.03 | 13 | 46206 | 1587 | 34909125 |
| Hyperbilirubinaemia | 12.72 | 11.03 | 50 | 46169 | 16793 | 34893919 |
| Osteochondrosis | 12.63 | 11.03 | 11 | 46208 | 1099 | 34909613 |
| Hypercreatininaemia | 12.59 | 11.03 | 8 | 46211 | 493 | 34910219 |
| Anti-erythropoietin antibody negative | 12.53 | 11.03 | 6 | 46213 | 211 | 34910501 |
| Hypoalbuminaemia | 12.51 | 11.03 | 40 | 46179 | 12134 | 34898578 |
| Volvulus | 12.51 | 11.03 | 13 | 46206 | 1619 | 34909093 |
| Sexually inappropriate behaviour | 12.43 | 11.03 | 8 | 46211 | 504 | 34910208 |
| Platelet count increased | 12.36 | 11.03 | 34 | 46185 | 9492 | 34901220 |
| Bacterial translocation | 12.29 | 11.03 | 7 | 46212 | 353 | 34910359 |
| Bloody discharge | 12.24 | 11.03 | 8 | 46211 | 518 | 34910194 |
| Communication disorder | 12.17 | 11.03 | 16 | 46203 | 2558 | 34908154 |
| Cytomegalovirus infection | 12.16 | 11.03 | 10 | 46209 | 26125 | 34884587 |
| Drug hypersensitivity | 12.08 | 11.03 | 60 | 46159 | 80469 | 34830243 |
| Erosive duodenitis | 11.91 | 11.03 | 13 | 46206 | 1711 | 34909001 |
| Application site hypersensitivity | 11.91 | 11.03 | 5 | 46214 | 128 | 34910584 |
| Cerebral arteriovenous malformation haemorrhagic | 11.89 | 11.03 | 4 | 46215 | 54 | 34910658 |
| Vision blurred | 11.88 | 11.03 | 27 | 46192 | 45936 | 34864776 |
| Erythema | 11.75 | 11.03 | 69 | 46150 | 88711 | 34822001 |
| Otorrhoea | 11.45 | 11.03 | 8 | 46211 | 578 | 34910134 |
| Diplopia | 11.41 | 11.03 | 4 | 46215 | 16839 | 34893873 |
| Stress | 11.39 | 11.03 | 14 | 46205 | 30333 | 34880379 |
| Abdominal cavity drainage | 11.37 | 11.03 | 7 | 46212 | 408 | 34910304 |
| Dyskinesia | 11.27 | 11.03 | 59 | 46160 | 22354 | 34888358 |
| Small intestinal obstruction | 11.12 | 11.03 | 44 | 46175 | 14822 | 34895890 |
| Adrenoleukodystrophy | 11.05 | 11.03 | 4 | 46215 | 68 | 34910644 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hepatic encephalopathy | 905.66 | 10.34 | 472 | 88806 | 23694 | 79631416 |
| Sedation complication | 688.97 | 10.34 | 341 | 88937 | 15328 | 79639782 |
| Creatinine renal clearance decreased | 618.60 | 10.34 | 338 | 88940 | 18664 | 79636446 |
| Orthostatic hypotension | 611.07 | 10.34 | 505 | 88773 | 55659 | 79599451 |
| Blood calcium decreased | 506.62 | 10.34 | 359 | 88919 | 31460 | 79623650 |
| Cognitive disorder | 478.75 | 10.34 | 485 | 88793 | 69441 | 79585669 |
| Sedation | 475.60 | 10.34 | 423 | 88855 | 51472 | 79603638 |
| Balance disorder | 413.36 | 10.34 | 531 | 88747 | 98326 | 79556784 |
| Drug ineffective | 377.79 | 10.34 | 394 | 88884 | 1080519 | 78574591 |
| Depressed level of consciousness | 344.06 | 10.34 | 480 | 88798 | 96172 | 79558938 |
| Constipation | 316.15 | 10.34 | 859 | 88419 | 282191 | 79372919 |
| Inability to afford medication | 260.85 | 10.34 | 103 | 89175 | 2670 | 79652440 |
| Fall | 259.30 | 10.34 | 1156 | 88122 | 486473 | 79168637 |
| Ammonia increased | 254.50 | 10.34 | 138 | 89140 | 7497 | 79647613 |
| Ascites | 213.76 | 10.34 | 337 | 88941 | 75225 | 79579885 |
| Hepatic cirrhosis | 204.64 | 10.34 | 223 | 89055 | 34683 | 79620427 |
| Confusional state | 201.59 | 10.34 | 796 | 88482 | 317201 | 79337909 |
| Blood bilirubin increased | 197.96 | 10.34 | 303 | 88975 | 65929 | 79589181 |
| Mobility decreased | 192.94 | 10.34 | 424 | 88854 | 121751 | 79533359 |
| Hypotension | 184.23 | 10.34 | 975 | 88303 | 439342 | 79215768 |
| Completed suicide | 179.00 | 10.34 | 30 | 89248 | 245737 | 79409373 |
| Hypomania | 173.19 | 10.34 | 107 | 89171 | 7437 | 79647673 |
| Jaundice cholestatic | 171.91 | 10.34 | 124 | 89154 | 11160 | 79643950 |
| Hepatic failure | 166.23 | 10.34 | 268 | 89010 | 60944 | 79594166 |
| Faecaloma | 164.68 | 10.34 | 122 | 89156 | 11442 | 79643668 |
| Schizophrenia | 159.84 | 10.34 | 135 | 89143 | 15305 | 79639805 |
| Hyponatraemia | 143.69 | 10.34 | 482 | 88796 | 177366 | 79477744 |
| Arthropathy | 132.58 | 10.34 | 20 | 89258 | 177091 | 79478019 |
| Rheumatoid arthritis | 132.21 | 10.34 | 35 | 89243 | 208435 | 79446675 |
| Drug hypersensitivity | 130.79 | 10.34 | 87 | 89191 | 298829 | 79356281 |
| Joint swelling | 123.63 | 10.34 | 86 | 89192 | 288560 | 79366550 |
| Arthralgia | 121.22 | 10.34 | 290 | 88988 | 571513 | 79083597 |
| Treatment failure | 119.36 | 10.34 | 23 | 89255 | 170463 | 79484647 |
| Drug intolerance | 118.08 | 10.34 | 75 | 89203 | 264044 | 79391066 |
| Haematemesis | 115.72 | 10.34 | 209 | 89069 | 52055 | 79603055 |
| Therapeutic product effect decreased | 112.84 | 10.34 | 23 | 89255 | 163840 | 79491270 |
| Hepatocellular carcinoma | 108.33 | 10.34 | 86 | 89192 | 8935 | 79646175 |
| Off label use | 107.87 | 10.34 | 587 | 88691 | 906628 | 78748482 |
| General physical health deterioration | 107.11 | 10.34 | 598 | 88680 | 274640 | 79380470 |
| Varices oesophageal | 105.62 | 10.34 | 72 | 89206 | 5919 | 79649191 |
| Sinusitis | 104.46 | 10.34 | 44 | 89234 | 195457 | 79459653 |
| Injection site pain | 101.07 | 10.34 | 13 | 89265 | 129825 | 79525285 |
| Systemic lupus erythematosus | 99.65 | 10.34 | 10 | 89268 | 121139 | 79533971 |
| Hand deformity | 98.93 | 10.34 | 4 | 89274 | 103915 | 79551195 |
| Infusion related reaction | 98.03 | 10.34 | 69 | 89209 | 230168 | 79424942 |
| Psychotic disorder | 96.06 | 10.34 | 169 | 89109 | 41233 | 79613877 |
| Swelling | 93.51 | 10.34 | 64 | 89214 | 216647 | 79438463 |
| Therapeutic product effect incomplete | 87.50 | 10.34 | 25 | 89253 | 141620 | 79513490 |
| Maternal exposure during pregnancy | 86.39 | 10.34 | 23 | 89255 | 136515 | 79518595 |
| Encephalopathy | 85.69 | 10.34 | 215 | 89063 | 67182 | 79587928 |
| Nasopharyngitis | 85.32 | 10.34 | 95 | 89183 | 253786 | 79401324 |
| Toxic epidermal necrolysis | 84.68 | 10.34 | 167 | 89111 | 44414 | 79610696 |
| Cholelithiasis | 82.19 | 10.34 | 182 | 89096 | 52482 | 79602628 |
| Hepatorenal syndrome | 81.96 | 10.34 | 54 | 89224 | 4195 | 79650915 |
| Hypersensitivity | 80.83 | 10.34 | 105 | 89173 | 262134 | 79392976 |
| Contraindicated product administered | 80.15 | 10.34 | 38 | 89240 | 157500 | 79497610 |
| Glossodynia | 78.87 | 10.34 | 11 | 89267 | 103326 | 79551784 |
| Neutropenic sepsis | 78.28 | 10.34 | 122 | 89156 | 26942 | 79628168 |
| Jaundice | 76.18 | 10.34 | 178 | 89100 | 53171 | 79601939 |
| Abdominal pain | 76.01 | 10.34 | 717 | 88561 | 388852 | 79266258 |
| Pneumatosis intestinalis | 74.71 | 10.34 | 60 | 89218 | 6337 | 79648773 |
| Drug abuse | 72.94 | 10.34 | 46 | 89232 | 162645 | 79492465 |
| Insurance issue | 71.74 | 10.34 | 56 | 89222 | 5677 | 79649433 |
| Oesophageal varices haemorrhage | 70.18 | 10.34 | 49 | 89229 | 4187 | 79650923 |
| Hyperkalaemia | 68.79 | 10.34 | 282 | 88996 | 114116 | 79540994 |
| Acute kidney injury | 68.28 | 10.34 | 884 | 88394 | 518520 | 79136590 |
| Rash | 67.00 | 10.34 | 377 | 88901 | 577981 | 79077129 |
| Hyperammonaemia | 66.97 | 10.34 | 72 | 89206 | 11021 | 79644089 |
| Total lung capacity increased | 66.90 | 10.34 | 38 | 89240 | 2260 | 79652850 |
| Peritonitis bacterial | 66.57 | 10.34 | 67 | 89211 | 9500 | 79645610 |
| Chronic hepatic failure | 65.98 | 10.34 | 29 | 89249 | 990 | 79654120 |
| Discomfort | 64.35 | 10.34 | 30 | 89248 | 125587 | 79529523 |
| Musculoskeletal stiffness | 63.85 | 10.34 | 61 | 89217 | 174947 | 79480163 |
| Alopecia | 62.10 | 10.34 | 102 | 89176 | 231253 | 79423857 |
| Portal hypertension | 61.24 | 10.34 | 56 | 89222 | 7052 | 79648058 |
| Dehydration | 59.94 | 10.34 | 479 | 88799 | 247708 | 79407402 |
| Abdominal distension | 59.78 | 10.34 | 279 | 88999 | 119371 | 79535739 |
| Hepatitis C | 59.35 | 10.34 | 70 | 89208 | 11855 | 79643255 |
| Urinary retention | 59.18 | 10.34 | 168 | 89110 | 56462 | 79598648 |
| Psoriatic arthropathy | 57.91 | 10.34 | 9 | 89269 | 77990 | 79577120 |
| Product use issue | 57.73 | 10.34 | 91 | 89187 | 209731 | 79445379 |
| Skin candida | 56.72 | 10.34 | 33 | 89245 | 2054 | 79653056 |
| Ileus | 55.70 | 10.34 | 103 | 89175 | 26108 | 79629002 |
| Asthma-chronic obstructive pulmonary disease overlap syndrome | 55.10 | 10.34 | 38 | 89240 | 3183 | 79651927 |
| Heart sounds | 51.48 | 10.34 | 24 | 89254 | 942 | 79654168 |
| Folliculitis | 49.94 | 10.34 | 3 | 89275 | 55377 | 79599733 |
| Hepatotoxicity | 49.48 | 10.34 | 148 | 89130 | 51204 | 79603906 |
| Arthritis | 49.43 | 10.34 | 34 | 89244 | 114846 | 79540264 |
| Lymphatic fistula | 49.25 | 10.34 | 22 | 89256 | 781 | 79654329 |
| Abdominal discomfort | 49.23 | 10.34 | 132 | 89146 | 250595 | 79404515 |
| Weight increased | 48.67 | 10.34 | 154 | 89124 | 277232 | 79377878 |
| Headache | 48.51 | 10.34 | 483 | 88795 | 653289 | 79001821 |
| Femoral hernia incarcerated | 48.25 | 10.34 | 22 | 89256 | 820 | 79654290 |
| Inappropriate schedule of product administration | 48.24 | 10.34 | 47 | 89231 | 133581 | 79521529 |
| Prolonged expiration | 48.08 | 10.34 | 25 | 89253 | 1246 | 79653864 |
| Pneumonia | 47.76 | 10.34 | 1019 | 88259 | 659227 | 78995883 |
| Gastric varices | 47.69 | 10.34 | 21 | 89257 | 720 | 79654390 |
| Injection site erythema | 46.11 | 10.34 | 15 | 89263 | 78182 | 79576928 |
| Pericarditis | 45.99 | 10.34 | 30 | 89248 | 104206 | 79550904 |
| Blood pressure increased | 45.60 | 10.34 | 106 | 89172 | 211254 | 79443856 |
| Aortic arteriosclerosis | 45.47 | 10.34 | 53 | 89225 | 8865 | 79646245 |
| Vomiting | 45.41 | 10.34 | 1019 | 88259 | 664809 | 78990301 |
| Neutrophil count increased | 45.19 | 10.34 | 101 | 89177 | 29295 | 79625815 |
| Urinary tract infection | 45.16 | 10.34 | 488 | 88790 | 274024 | 79381086 |
| Wound infection pseudomonas | 45.03 | 10.34 | 26 | 89252 | 1595 | 79653515 |
| Hypernatraemia | 44.40 | 10.34 | 67 | 89211 | 14384 | 79640726 |
| Abdominal tenderness | 44.35 | 10.34 | 57 | 89221 | 10537 | 79644573 |
| Intentional product use issue | 43.73 | 10.34 | 64 | 89214 | 152048 | 79503062 |
| Helicobacter infection | 43.59 | 10.34 | 12 | 89266 | 69692 | 79585418 |
| Muscle injury | 42.69 | 10.34 | 3 | 89275 | 48558 | 79606552 |
| Anaemia | 42.14 | 10.34 | 716 | 88562 | 444299 | 79210811 |
| Pancreatic steatosis | 41.82 | 10.34 | 22 | 89256 | 1123 | 79653987 |
| Sepsis | 41.59 | 10.34 | 473 | 88805 | 268955 | 79386155 |
| Therapeutic response decreased | 40.90 | 10.34 | 12 | 89266 | 66841 | 79588269 |
| Wound | 40.64 | 10.34 | 42 | 89236 | 116137 | 79538973 |
| Portal hypertensive gastropathy | 40.14 | 10.34 | 23 | 89255 | 1391 | 79653719 |
| Urticaria | 39.85 | 10.34 | 93 | 89185 | 185108 | 79470002 |
| Hypokalaemia | 39.79 | 10.34 | 287 | 88991 | 143753 | 79511357 |
| Alveolar lung disease | 39.24 | 10.34 | 17 | 89261 | 560 | 79654550 |
| Delirium | 39.12 | 10.34 | 193 | 89085 | 84434 | 79570676 |
| Melaena | 38.90 | 10.34 | 153 | 89125 | 60737 | 79594373 |
| Liver function test abnormal | 38.79 | 10.34 | 159 | 89119 | 64316 | 79590794 |
| Irritable bowel syndrome | 38.40 | 10.34 | 11 | 89267 | 62230 | 79592880 |
| Exposure during pregnancy | 38.36 | 10.34 | 34 | 89244 | 101098 | 79554012 |
| Ill-defined disorder | 38.21 | 10.34 | 13 | 89265 | 65862 | 79589248 |
| Cirrhosis alcoholic | 37.70 | 10.34 | 20 | 89258 | 1039 | 79654071 |
| Pulmonary interstitial emphysema syndrome | 37.51 | 10.34 | 16 | 89262 | 507 | 79654603 |
| Injection site reaction | 37.06 | 10.34 | 8 | 89270 | 54777 | 79600333 |
| Psoriasis | 36.60 | 10.34 | 28 | 89250 | 89559 | 79565551 |
| Haemoglobin decreased | 35.65 | 10.34 | 393 | 88885 | 221726 | 79433384 |
| Multiple drug therapy | 34.88 | 10.34 | 32 | 89246 | 4046 | 79651064 |
| Product dose omission issue | 34.53 | 10.34 | 151 | 89127 | 247386 | 79407724 |
| White blood cell count increased | 34.35 | 10.34 | 170 | 89108 | 74463 | 79580647 |
| Arterial haemorrhage | 34.19 | 10.34 | 26 | 89252 | 2535 | 79652575 |
| Disorientation | 34.04 | 10.34 | 150 | 89128 | 62626 | 79592484 |
| Systemic infection | 34.00 | 10.34 | 48 | 89230 | 9704 | 79645406 |
| Hypertension | 33.93 | 10.34 | 224 | 89054 | 330768 | 79324342 |
| Fatigue | 33.92 | 10.34 | 788 | 88490 | 928939 | 78726171 |
| Intestinal pseudo-obstruction | 33.77 | 10.34 | 26 | 89252 | 2583 | 79652527 |
| Injection site swelling | 33.73 | 10.34 | 6 | 89272 | 47126 | 79607984 |
| Mental status changes | 33.33 | 10.34 | 156 | 89122 | 66803 | 79588307 |
| Blood cholesterol increased | 33.15 | 10.34 | 27 | 89251 | 83693 | 79571417 |
| Asterixis | 32.92 | 10.34 | 26 | 89252 | 2681 | 79652429 |
| C-reactive protein abnormal | 32.84 | 10.34 | 7 | 89271 | 48360 | 79606750 |
| Liver transplant | 32.67 | 10.34 | 32 | 89246 | 4391 | 79650719 |
| Gastrointestinal disorder | 32.65 | 10.34 | 54 | 89224 | 122151 | 79532959 |
| Injection site bruising | 32.15 | 10.34 | 4 | 89274 | 40998 | 79614112 |
| Sarcoidosis | 32.03 | 10.34 | 43 | 89235 | 8292 | 79646818 |
| Gastrointestinal haemorrhage | 31.84 | 10.34 | 278 | 89000 | 147441 | 79507669 |
| Nasal polyps | 31.58 | 10.34 | 40 | 89238 | 7287 | 79647823 |
| High-grade B-cell lymphoma | 31.58 | 10.34 | 10 | 89268 | 132 | 79654978 |
| Injection site pruritus | 31.11 | 10.34 | 5 | 89273 | 42278 | 79612832 |
| Benign gastrointestinal neoplasm | 31.10 | 10.34 | 10 | 89268 | 139 | 79654971 |
| Periarthritis calcarea | 31.05 | 10.34 | 9 | 89269 | 86 | 79655024 |
| Peripheral swelling | 30.46 | 10.34 | 177 | 89101 | 269440 | 79385670 |
| Hypoaesthesia | 30.45 | 10.34 | 101 | 89177 | 179251 | 79475859 |
| Seroma | 29.94 | 10.34 | 23 | 89255 | 2277 | 79652833 |
| Hypermagnesaemia | 29.46 | 10.34 | 18 | 89260 | 1226 | 79653884 |
| Therapy non-responder | 29.40 | 10.34 | 36 | 89242 | 92269 | 79562841 |
| Hip arthroplasty | 29.27 | 10.34 | 3 | 89275 | 35753 | 79619357 |
| Drug resistance | 28.89 | 10.34 | 6 | 89272 | 42207 | 79612903 |
| Intentional overdose | 28.14 | 10.34 | 47 | 89231 | 105913 | 79549197 |
| Antipsychotic drug level increased | 28.06 | 10.34 | 34 | 89244 | 5923 | 79649187 |
| Dementia | 27.58 | 10.34 | 75 | 89203 | 24584 | 79630526 |
| Lethargy | 27.27 | 10.34 | 170 | 89108 | 81122 | 79573988 |
| Therapy interrupted | 27.10 | 10.34 | 87 | 89191 | 31254 | 79623856 |
| Pain in extremity | 27.10 | 10.34 | 269 | 89009 | 364269 | 79290841 |
| Osteoarthritis | 26.82 | 10.34 | 35 | 89243 | 87274 | 79567836 |
| Wrong technique in product usage process | 26.64 | 10.34 | 26 | 89252 | 73849 | 79581261 |
| Erythema | 26.62 | 10.34 | 144 | 89134 | 223146 | 79431964 |
| Diverticulum intestinal | 26.58 | 10.34 | 40 | 89238 | 8565 | 79646545 |
| COVID-19 | 25.94 | 10.34 | 90 | 89188 | 157584 | 79497526 |
| Herpes zoster | 25.93 | 10.34 | 40 | 89238 | 93043 | 79562067 |
| Adrenal cyst | 25.85 | 10.34 | 9 | 89269 | 162 | 79654948 |
| Upper gastrointestinal haemorrhage | 25.64 | 10.34 | 103 | 89175 | 41277 | 79613833 |
| Seizure | 24.96 | 10.34 | 322 | 88956 | 188512 | 79466598 |
| Nail dystrophy | 24.87 | 10.34 | 15 | 89263 | 998 | 79654112 |
| Suicide attempt | 24.71 | 10.34 | 34 | 89244 | 82898 | 79572212 |
| Hallucination | 24.34 | 10.34 | 172 | 89106 | 85573 | 79569537 |
| Hepatic cyst | 24.30 | 10.34 | 32 | 89246 | 6057 | 79649053 |
| Pruritus | 24.27 | 10.34 | 304 | 88974 | 394344 | 79260766 |
| Conjunctival irritation | 23.85 | 10.34 | 8 | 89270 | 128 | 79654982 |
| Blood pressure fluctuation | 23.79 | 10.34 | 24 | 89254 | 67121 | 79587989 |
| Articular calcification | 23.63 | 10.34 | 9 | 89269 | 211 | 79654899 |
| Oedema peripheral | 23.49 | 10.34 | 405 | 88873 | 251883 | 79403227 |
| Red blood cell sedimentation rate increased | 23.48 | 10.34 | 11 | 89267 | 45931 | 79609179 |
| Femoral neck fracture | 23.47 | 10.34 | 41 | 89237 | 9943 | 79645167 |
| Pyramidal tract syndrome | 23.32 | 10.34 | 12 | 89266 | 585 | 79654525 |
| Spinal cord paralysis | 23.29 | 10.34 | 8 | 89270 | 138 | 79654972 |
| Urinary incontinence | 23.13 | 10.34 | 99 | 89179 | 40810 | 79614300 |
| Wrong patient received product | 22.80 | 10.34 | 27 | 89251 | 4591 | 79650519 |
| Fibromyalgia | 22.79 | 10.34 | 23 | 89255 | 64317 | 79590793 |
| Dyskinesia | 22.78 | 10.34 | 105 | 89173 | 44668 | 79610442 |
| Cholestasis of pregnancy | 22.58 | 10.34 | 14 | 89264 | 979 | 79654131 |
| Blood pressure systolic increased | 22.55 | 10.34 | 25 | 89253 | 66961 | 79588149 |
| Product use in unapproved indication | 22.45 | 10.34 | 176 | 89102 | 250183 | 79404927 |
| Joint injury | 22.40 | 10.34 | 4 | 89274 | 31331 | 79623779 |
| Hypophagia | 22.06 | 10.34 | 105 | 89173 | 45262 | 79609848 |
| Hyperammonaemic encephalopathy | 22.04 | 10.34 | 27 | 89251 | 4755 | 79650355 |
| Cardiac murmur | 21.72 | 10.34 | 52 | 89226 | 15772 | 79639338 |
| Product prescribing error | 21.27 | 10.34 | 103 | 89175 | 44710 | 79610400 |
| Intestinal obstruction | 21.24 | 10.34 | 100 | 89178 | 42920 | 79612190 |
| Adverse drug reaction | 21.03 | 10.34 | 26 | 89252 | 66366 | 79588744 |
| Myalgia | 20.88 | 10.34 | 122 | 89156 | 185519 | 79469591 |
| Death | 20.85 | 10.34 | 803 | 88475 | 565711 | 79089399 |
| Haemarthrosis | 20.85 | 10.34 | 29 | 89249 | 5783 | 79649327 |
| Intestinal dilatation | 20.82 | 10.34 | 20 | 89258 | 2680 | 79652430 |
| Disturbance in attention | 20.79 | 10.34 | 112 | 89166 | 50689 | 79604421 |
| Migraine | 20.40 | 10.34 | 42 | 89236 | 87451 | 79567659 |
| Freezing phenomenon | 20.35 | 10.34 | 17 | 89261 | 1897 | 79653213 |
| Obesity | 20.25 | 10.34 | 7 | 89271 | 35118 | 79619992 |
| Colitis ulcerative | 19.90 | 10.34 | 7 | 89271 | 34735 | 79620375 |
| Arteriosclerosis coronary artery | 19.73 | 10.34 | 54 | 89224 | 17762 | 79637348 |
| Functional gastrointestinal disorder | 19.57 | 10.34 | 26 | 89252 | 4964 | 79650146 |
| Hiccups | 19.56 | 10.34 | 38 | 89240 | 9993 | 79645117 |
| On and off phenomenon | 19.51 | 10.34 | 21 | 89257 | 3219 | 79651891 |
| Ureaplasma infection | 19.42 | 10.34 | 13 | 89265 | 1037 | 79654073 |
| Portal vein thrombosis | 19.32 | 10.34 | 28 | 89250 | 5799 | 79649311 |
| Peritonitis | 19.18 | 10.34 | 72 | 89206 | 27964 | 79627146 |
| Hepatic calcification | 19.08 | 10.34 | 9 | 89269 | 363 | 79654747 |
| Hepatitis C RNA positive | 19.01 | 10.34 | 8 | 89270 | 245 | 79654865 |
| Oropharyngeal pain | 18.95 | 10.34 | 61 | 89217 | 109292 | 79545818 |
| Heart rate decreased | 18.85 | 10.34 | 31 | 89247 | 70285 | 79584825 |
| Bradycardia | 18.69 | 10.34 | 233 | 89045 | 135324 | 79519786 |
| Dermatitis bullous | 18.68 | 10.34 | 46 | 89232 | 14199 | 79640911 |
| Inflammation | 18.65 | 10.34 | 49 | 89229 | 93704 | 79561406 |
| Axillary pain | 18.65 | 10.34 | 17 | 89261 | 2132 | 79652978 |
| Abortion spontaneous | 18.60 | 10.34 | 5 | 89273 | 29502 | 79625608 |
| Costal cartilage fracture | 18.54 | 10.34 | 8 | 89270 | 261 | 79654849 |
| Accidental exposure to product | 18.48 | 10.34 | 6 | 89272 | 31316 | 79623794 |
| Aspiration | 18.39 | 10.34 | 57 | 89221 | 20101 | 79635009 |
| Escherichia infection | 18.38 | 10.34 | 53 | 89225 | 17964 | 79637146 |
| Aortic valve stenosis | 18.37 | 10.34 | 26 | 89252 | 5268 | 79649842 |
| Hallucination, visual | 18.34 | 10.34 | 79 | 89199 | 32650 | 79622460 |
| Acute abdomen | 18.30 | 10.34 | 20 | 89258 | 3117 | 79651993 |
| Platelet count decreased | 18.29 | 10.34 | 313 | 88965 | 194351 | 79460759 |
| Stoma site discharge | 18.25 | 10.34 | 17 | 89261 | 2192 | 79652918 |
| Adrenomegaly | 18.22 | 10.34 | 9 | 89269 | 402 | 79654708 |
| Wound dehiscence | 18.06 | 10.34 | 29 | 89249 | 6566 | 79648544 |
| Epilepsy | 18.04 | 10.34 | 92 | 89186 | 40768 | 79614342 |
| Asthma | 17.87 | 10.34 | 84 | 89194 | 135011 | 79520099 |
| Flail chest | 17.71 | 10.34 | 6 | 89272 | 99 | 79655011 |
| Adverse event | 17.62 | 10.34 | 25 | 89253 | 60189 | 79594921 |
| Hypervolaemia | 17.39 | 10.34 | 94 | 89184 | 42596 | 79612514 |
| Spleen congestion | 17.37 | 10.34 | 9 | 89269 | 445 | 79654665 |
| Lung perforation | 17.28 | 10.34 | 6 | 89272 | 107 | 79655003 |
| Differential white blood cell count abnormal | 17.19 | 10.34 | 16 | 89262 | 2061 | 79653049 |
| Appetite disorder | 17.19 | 10.34 | 31 | 89247 | 7708 | 79647402 |
| Genital erythema | 17.11 | 10.34 | 8 | 89270 | 316 | 79654794 |
| Pneumonia aspiration | 17.10 | 10.34 | 131 | 89147 | 66836 | 79588274 |
| Metamyelocyte count increased | 17.08 | 10.34 | 10 | 89268 | 630 | 79654480 |
| Thrombocytopenia | 17.07 | 10.34 | 403 | 88875 | 264856 | 79390254 |
| Night sweats | 16.93 | 10.34 | 20 | 89258 | 52075 | 79603035 |
| Erosive duodenitis | 16.93 | 10.34 | 16 | 89262 | 2101 | 79653009 |
| Body mass index decreased | 16.75 | 10.34 | 10 | 89268 | 653 | 79654457 |
| Impaired healing | 16.55 | 10.34 | 47 | 89231 | 87608 | 79567502 |
| Alkalosis hypochloraemic | 16.49 | 10.34 | 9 | 89269 | 495 | 79654615 |
| Throat irritation | 16.46 | 10.34 | 13 | 89265 | 40933 | 79614177 |
| Ear infection | 16.46 | 10.34 | 9 | 89269 | 34423 | 79620687 |
| Infection | 16.46 | 10.34 | 182 | 89096 | 241530 | 79413580 |
| Abnormal faeces | 16.40 | 10.34 | 30 | 89248 | 7541 | 79647569 |
| Plasma cell myeloma | 16.39 | 10.34 | 109 | 89169 | 53150 | 79601960 |
| Feeling hot | 16.32 | 10.34 | 26 | 89252 | 59708 | 79595402 |
| Activated partial thromboplastin time shortened | 16.31 | 10.34 | 11 | 89267 | 888 | 79654222 |
| Bronchitis | 16.26 | 10.34 | 83 | 89195 | 130561 | 79524549 |
| Intentional self-injury | 16.20 | 10.34 | 8 | 89270 | 32411 | 79622699 |
| Blood albumin abnormal | 16.20 | 10.34 | 10 | 89268 | 694 | 79654416 |
| Rectal haemorrhage | 16.12 | 10.34 | 143 | 89135 | 76157 | 79578953 |
| Toxicity to various agents | 16.08 | 10.34 | 600 | 88678 | 420940 | 79234170 |
| Depressed mood | 16.01 | 10.34 | 101 | 89177 | 48379 | 79606731 |
| Hyperbilirubinaemia | 15.97 | 10.34 | 62 | 89216 | 24456 | 79630654 |
| Blood alkaline phosphatase increased | 15.95 | 10.34 | 124 | 89154 | 63540 | 79591570 |
| Depressive symptom | 15.92 | 10.34 | 27 | 89251 | 6396 | 79648714 |
| Respiration abnormal | 15.79 | 10.34 | 30 | 89248 | 7758 | 79647352 |
| Portal shunt procedure | 15.72 | 10.34 | 4 | 89274 | 22 | 79655088 |
| Inguinal hernia | 15.72 | 10.34 | 27 | 89251 | 6461 | 79648649 |
| Subileus | 15.67 | 10.34 | 25 | 89253 | 5629 | 79649481 |
| Pulmonary vein occlusion | 15.66 | 10.34 | 6 | 89272 | 143 | 79654967 |
| Splenomegaly | 15.63 | 10.34 | 55 | 89223 | 20699 | 79634411 |
| Portal shunt | 15.45 | 10.34 | 5 | 89273 | 71 | 79655039 |
| Blister | 15.39 | 10.34 | 75 | 89203 | 119401 | 79535709 |
| Nephrocalcinosis | 15.27 | 10.34 | 13 | 89265 | 1489 | 79653621 |
| Dysphagia | 15.19 | 10.34 | 206 | 89072 | 121930 | 79533180 |
| Stomatitis | 15.17 | 10.34 | 99 | 89179 | 146658 | 79508452 |
| Abdominal rigidity | 15.16 | 10.34 | 18 | 89260 | 3070 | 79652040 |
| Salivary gland enlargement | 15.04 | 10.34 | 8 | 89270 | 418 | 79654692 |
| Eye pain | 15.02 | 10.34 | 12 | 89266 | 37566 | 79617544 |
| Bleeding time prolonged | 14.93 | 10.34 | 12 | 89266 | 1269 | 79653841 |
| Hepatic cancer | 14.88 | 10.34 | 35 | 89243 | 10494 | 79644616 |
| Immature granulocyte count increased | 14.81 | 10.34 | 9 | 89269 | 607 | 79654503 |
| Oral contusion | 14.79 | 10.34 | 5 | 89273 | 82 | 79655028 |
| Blood sodium decreased | 14.77 | 10.34 | 75 | 89203 | 33180 | 79621930 |
| Vascular encephalopathy | 14.72 | 10.34 | 9 | 89269 | 614 | 79654496 |
| Monocyte count increased | 14.59 | 10.34 | 35 | 89243 | 10626 | 79644484 |
| Intentional product misuse | 14.54 | 10.34 | 56 | 89222 | 95109 | 79560001 |
| Pleural effusion | 14.54 | 10.34 | 236 | 89042 | 145026 | 79510084 |
| Hiatus hernia | 14.42 | 10.34 | 58 | 89220 | 23254 | 79631856 |
| Mouth swelling | 14.42 | 10.34 | 25 | 89253 | 6026 | 79649084 |
| Paracentesis | 14.41 | 10.34 | 12 | 89266 | 1333 | 79653777 |
| Rhinitis allergic | 14.41 | 10.34 | 38 | 89240 | 12231 | 79642879 |
| Nodule | 14.30 | 10.34 | 4 | 89274 | 22990 | 79632120 |
| Drug ineffective for unapproved indication | 14.29 | 10.34 | 22 | 89256 | 51216 | 79603894 |
| Feeling abnormal | 14.22 | 10.34 | 112 | 89166 | 159087 | 79496023 |
| Unresponsive to stimuli | 14.17 | 10.34 | 109 | 89169 | 55679 | 79599431 |
| Cardiac disorder | 14.15 | 10.34 | 33 | 89245 | 65724 | 79589386 |
| Prescribed overdose | 14.05 | 10.34 | 13 | 89265 | 37870 | 79617240 |
| Salivary gland disorder | 13.98 | 10.34 | 7 | 89271 | 322 | 79654788 |
| Road traffic accident | 13.93 | 10.34 | 17 | 89261 | 43647 | 79611463 |
| Lactic acidosis | 13.92 | 10.34 | 130 | 89148 | 70229 | 79584881 |
| Injection site haemorrhage | 13.74 | 10.34 | 7 | 89271 | 27863 | 79627247 |
| Full blood count abnormal | 13.74 | 10.34 | 15 | 89263 | 40459 | 79614651 |
| Activated partial thromboplastin time abnormal | 13.65 | 10.34 | 7 | 89271 | 339 | 79654771 |
| Incoherent | 13.63 | 10.34 | 28 | 89250 | 7664 | 79647446 |
| Blast cells present | 13.60 | 10.34 | 10 | 89268 | 927 | 79654183 |
| Weight | 13.55 | 10.34 | 4 | 89274 | 41 | 79655069 |
| Stoma site erythema | 13.54 | 10.34 | 13 | 89265 | 1740 | 79653370 |
| Nail infection | 13.49 | 10.34 | 15 | 89263 | 2384 | 79652726 |
| Circulatory collapse | 13.40 | 10.34 | 80 | 89198 | 37588 | 79617522 |
| Megacolon | 13.38 | 10.34 | 18 | 89260 | 3477 | 79651633 |
| Neutropenia | 13.35 | 10.34 | 419 | 88859 | 287291 | 79367819 |
| Anxiety | 13.25 | 10.34 | 197 | 89081 | 248315 | 79406795 |
| Grip strength decreased | 13.24 | 10.34 | 4 | 89274 | 21865 | 79633245 |
| Thoracic operation | 13.22 | 10.34 | 6 | 89272 | 221 | 79654889 |
| Tachyarrhythmia | 13.12 | 10.34 | 26 | 89252 | 6936 | 79648174 |
| Diabetic gastropathy | 13 | 10.34 | 3 | 89275 | 10 | 79655100 |
| Toxic encephalopathy | 13.00 | 10.34 | 35 | 89243 | 11405 | 79643705 |
| Myelocyte count increased | 12.98 | 10.34 | 9 | 89269 | 760 | 79654350 |
| Premature delivery | 12.98 | 10.34 | 5 | 89273 | 23462 | 79631648 |
| Illness | 12.94 | 10.34 | 20 | 89258 | 46491 | 79608619 |
| Spinal cord injury thoracic | 12.91 | 10.34 | 5 | 89273 | 123 | 79654987 |
| Bladder cancer | 12.90 | 10.34 | 3 | 89275 | 19523 | 79635587 |
| Groin pain | 12.88 | 10.34 | 38 | 89240 | 13042 | 79642068 |
| Vascular parkinsonism | 12.87 | 10.34 | 5 | 89273 | 124 | 79654986 |
| Pregnancy | 12.86 | 10.34 | 7 | 89271 | 26844 | 79628266 |
| Portal tract inflammation | 12.79 | 10.34 | 5 | 89273 | 126 | 79654984 |
| Peripheral artery stenosis | 12.62 | 10.34 | 11 | 89267 | 1300 | 79653810 |
| Anaphylactic shock | 12.60 | 10.34 | 13 | 89265 | 35983 | 79619127 |
| Gastrointestinal tract mucosal pigmentation | 12.59 | 10.34 | 10 | 89268 | 1040 | 79654070 |
| Electrolyte imbalance | 12.58 | 10.34 | 68 | 89210 | 30813 | 79624297 |
| Fungal infection | 12.55 | 10.34 | 17 | 89261 | 41731 | 79613379 |
| Blood albumin decreased | 12.44 | 10.34 | 57 | 89221 | 24186 | 79630924 |
| Throat tightness | 12.35 | 10.34 | 8 | 89270 | 27899 | 79627211 |
| Nervous system disorder | 12.23 | 10.34 | 61 | 89217 | 26795 | 79628315 |
| Flushing | 12.20 | 10.34 | 54 | 89224 | 88214 | 79566896 |
| Dry eye | 12.19 | 10.34 | 14 | 89264 | 36917 | 79618193 |
| Influenza | 12.13 | 10.34 | 90 | 89188 | 129516 | 79525594 |
| Coma hepatic | 12.07 | 10.34 | 10 | 89268 | 1103 | 79654007 |
| Stress | 12.06 | 10.34 | 47 | 89231 | 79565 | 79575545 |
| Acute hepatic failure | 12.06 | 10.34 | 66 | 89212 | 30047 | 79625063 |
| Incontinence | 11.96 | 10.34 | 39 | 89239 | 14125 | 79640985 |
| Vascular purpura | 11.93 | 10.34 | 16 | 89262 | 3082 | 79652028 |
| Muscle twitching | 11.81 | 10.34 | 57 | 89221 | 24707 | 79630403 |
| Contusion | 11.79 | 10.34 | 108 | 89170 | 148668 | 79506442 |
| Bronchiectasis | 11.76 | 10.34 | 53 | 89225 | 22333 | 79632777 |
| Small intestinal obstruction | 11.76 | 10.34 | 61 | 89217 | 27211 | 79627899 |
| Adrenoleukodystrophy | 11.70 | 10.34 | 4 | 89274 | 68 | 79655042 |
| Anal injury | 11.59 | 10.34 | 5 | 89273 | 163 | 79654947 |
| Poisoning | 11.52 | 10.34 | 7 | 89271 | 25265 | 79629845 |
| Diffuse alveolar damage | 11.49 | 10.34 | 17 | 89261 | 3587 | 79651523 |
| Portopulmonary hypertension | 11.45 | 10.34 | 5 | 89273 | 168 | 79654942 |
| Duodenal ulcer haemorrhage | 11.45 | 10.34 | 25 | 89253 | 7138 | 79647972 |
| Polypectomy | 11.39 | 10.34 | 10 | 89268 | 1194 | 79653916 |
| Superinfection | 11.35 | 10.34 | 20 | 89258 | 4882 | 79650228 |
| Hydronephrosis | 11.26 | 10.34 | 44 | 89234 | 17410 | 79637700 |
| Cytomegalovirus infection | 11.24 | 10.34 | 19 | 89259 | 42625 | 79612485 |
| Cataract | 11.22 | 10.34 | 34 | 89244 | 62086 | 79593024 |
| Cardiomyopathy acute | 11.22 | 10.34 | 6 | 89272 | 317 | 79654793 |
| Heart rate irregular | 11.21 | 10.34 | 12 | 89266 | 32667 | 79622443 |
| Colon cancer metastatic | 11.18 | 10.34 | 13 | 89265 | 2168 | 79652942 |
| Vision blurred | 11.17 | 10.34 | 71 | 89207 | 105827 | 79549283 |
| Duodenal ulcer | 11.16 | 10.34 | 42 | 89236 | 16327 | 79638783 |
| Interstitial lung disease | 11.12 | 10.34 | 77 | 89201 | 112523 | 79542587 |
| Gastrointestinal sounds abnormal | 11.10 | 10.34 | 21 | 89257 | 5414 | 79649696 |
| Anti-erythropoietin antibody negative | 11.08 | 10.34 | 6 | 89272 | 325 | 79654785 |
| Hyperglycaemia | 11.06 | 10.34 | 124 | 89154 | 70211 | 79584899 |
| Product quality issue | 11.06 | 10.34 | 13 | 89265 | 33927 | 79621183 |
| Left ventricular dysfunction | 11.06 | 10.34 | 47 | 89231 | 19314 | 79635796 |
| Cardiac failure congestive | 11.02 | 10.34 | 104 | 89174 | 142298 | 79512812 |
| Lip swelling | 10.99 | 10.34 | 81 | 89197 | 40830 | 79614280 |
| Rash vesicular | 10.96 | 10.34 | 22 | 89256 | 5923 | 79649187 |
| Adrenal adenoma | 10.95 | 10.34 | 10 | 89268 | 1257 | 79653853 |
| Alpha 1 foetoprotein decreased | 10.94 | 10.34 | 3 | 89275 | 23 | 79655087 |
| Hypoalbuminaemia | 10.87 | 10.34 | 50 | 89228 | 21247 | 79633863 |
| Bilirubin conjugated increased | 10.82 | 10.34 | 21 | 89257 | 5518 | 79649592 |
| Body temperature decreased | 10.81 | 10.34 | 12 | 89266 | 32133 | 79622977 |
| Heart rate increased | 10.75 | 10.34 | 85 | 89193 | 120639 | 79534471 |
| Hepatitis acute | 10.70 | 10.34 | 40 | 89238 | 15502 | 79639608 |
| Sexually inappropriate behaviour | 10.69 | 10.34 | 7 | 89271 | 538 | 79654572 |
| Hypertriglyceridaemia | 10.68 | 10.34 | 35 | 89243 | 12705 | 79642405 |
| Cytokine release syndrome | 10.68 | 10.34 | 73 | 89205 | 35925 | 79619185 |
| Tumour hyperprogression | 10.61 | 10.34 | 5 | 89273 | 201 | 79654909 |
| Lung neoplasm malignant | 10.52 | 10.34 | 60 | 89218 | 27732 | 79627378 |
| Food refusal | 10.52 | 10.34 | 7 | 89271 | 553 | 79654557 |
| Neck pain | 10.51 | 10.34 | 46 | 89232 | 75371 | 79579739 |
| Poisoning deliberate | 10.43 | 10.34 | 4 | 89274 | 18824 | 79636286 |
| Chronotropic incompetence | 10.42 | 10.34 | 4 | 89274 | 96 | 79655014 |
| Bursitis | 10.37 | 10.34 | 15 | 89263 | 35829 | 79619281 |
| Alkalosis | 10.36 | 10.34 | 7 | 89271 | 567 | 79654543 |
| Injury | 10.36 | 10.34 | 48 | 89230 | 77448 | 79577662 |
| Failure to thrive | 10.35 | 10.34 | 33 | 89245 | 11811 | 79643299 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A06AD11 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Osmotically acting laxatives |
| ATC | A06AD61 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Osmotically acting laxatives |
| FDA PE | N0000009871 | Stimulation Large Intestine Fluid/Electrolyte Secretion |
| FDA MoA | N0000010288 | Osmotic Activity |
| MeSH PA | D005765 | Gastrointestinal Agents |
| CHEBI has role | CHEBI:50503 | laxante |
| CHEBI has role | CHEBI:55324 | gastrointestinal drugs |
| FDA EPC | N0000175811 | Osmotic Laxative |
| FDA MoA | N0000175833 | Acidifying Activity |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hyperammonemia | indication | 9360008 | |
| Hepatic encephalopathy | indication | 13920009 | DOID:13413 |
| Constipation | indication | 14760008 | DOID:2089 |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Appendicitis | contraindication | 74400008 | DOID:8337 |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Galactosemia | contraindication | 190745006 | DOID:9870 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.04 | acidic |
| pKa2 | 13.36 | acidic |
| pKa3 | 13.8 | acidic |
| pKa4 | 13.97 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4018617 | VUID |
| N0000146930 | NUI |
| D00352 | KEGG_DRUG |
| 4018617 | VANDF |
| C0022957 | UMLSCUI |
| CHEBI:6359 | CHEBI |
| CHEMBL1237068 | ChEMBL_ID |
| CHEMBL296306 | ChEMBL_ID |
| DB00581 | DRUGBANK_ID |
| D007792 | MESH_DESCRIPTOR_UI |
| 11333 | PUBCHEM_CID |
| 2137 | INN_ID |
| 9U7D5QH5AE | UNII |
| 215949 | RXNORM |
| 117 | MMSL |
| 4512 | MMSL |
| 4955 | MMSL |
| d01024 | MMSL |
| 001241 | NDDF |
| 111137007 | SNOMEDCT_US |
| 273945008 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Lactulose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0116-4005 | SOLUTION | 10 g | ORAL | ANDA | 20 sections |
| Lactulose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0116-4005 | SOLUTION | 10 g | ORAL | ANDA | 20 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0577 | SOLUTION | 10 g | ORAL | ANDA | 22 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0577 | SOLUTION | 10 g | ORAL | ANDA | 22 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0577 | SOLUTION | 10 g | ORAL | ANDA | 22 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0873 | SOLUTION | 10 g | ORAL | ANDA | 22 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0873 | SOLUTION | 10 g | ORAL | ANDA | 22 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1154 | SOLUTION | 20 g | ORAL | ANDA | 22 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1154 | SOLUTION | 20 g | ORAL | ANDA | 22 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1154 | SOLUTION | 20 g | ORAL | ANDA | 22 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1746 | SOLUTION | 20 g | ORAL | ANDA | 22 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1746 | SOLUTION | 20 g | ORAL | ANDA | 22 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-4577 | SOLUTION | 10 g | ORAL | ANDA | 22 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-4577 | SOLUTION | 10 g | ORAL | ANDA | 22 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-4577 | SOLUTION | 10 g | ORAL | ANDA | 22 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-5120 | SOLUTION | 10 g | ORAL | ANDA | 22 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-5120 | SOLUTION | 10 g | ORAL | ANDA | 22 sections |
| LACTULOSE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-5125 | SOLUTION | 10 g | ORAL | ANDA | 22 sections |
| Lactulose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-574 | SOLUTION | 10 g | ORAL | ANDA | 12 sections |
| Lactulose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-574 | SOLUTION | 10 g | ORAL | ANDA | 12 sections |
| Lactulose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-580 | SOLUTION | 10 g | ORAL | ANDA | 21 sections |
| Lactulose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-580 | SOLUTION | 10 g | ORAL | ANDA | 21 sections |
| Lactulose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-1378 | SOLUTION | 10 g | ORAL | ANDA | 22 sections |
| Lactulose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 18124-002 | SOLUTION | 10 g | ORAL | ANDA | 16 sections |
| Lactulose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 18124-002 | SOLUTION | 10 g | ORAL | ANDA | 16 sections |
| Lactulose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-997 | SOLUTION | 10 g | ORAL | ANDA | 11 sections |
| Enulose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45963-438 | SOLUTION | 10 g | ORAL | ANDA | 17 sections |
| Enulose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45963-438 | SOLUTION | 10 g | ORAL | ANDA | 17 sections |
| Constulose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45963-439 | SOLUTION | 10 g | ORAL | ANDA | 19 sections |
| Constulose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45963-439 | SOLUTION | 10 g | ORAL | ANDA | 19 sections |