magnesium carbonate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4288	546-93-0

Description:

Molecule	Description
Synonyms: magnesium carbonate carbonic acid magnesium salt	Molecular weight: 84.31 Formula: CMgO3 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

magnesium carbonate
carbonic acid magnesium salt

Molecular weight: 84.31
Formula: CMgO3
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
7	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 2, 1990	FDA	UNITED GUARDIAN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Coma scale abnormal	27.02	19.15	10	2680	4761	50597673
Hyponatraemia	26.56	19.15	29	2661	96110	50506324
Morbid thoughts	26.07	19.15	6	2684	536	50601898
Agitation	21.95	19.15	20	2670	53364	50549070
Drug ineffective	20.59	19.15	9	2681	819324	49783110
Confusional state	20.55	19.15	36	2654	185892	50416542
Acute kidney injury	20.02	19.15	40	2650	228018	50374416

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Mesothelioma	38.33	20.52	8	1752	405	29572362
Violence-related symptom	25.80	20.52	6	1754	501	29572266
Eyelid ptosis congenital	22.17	20.52	4	1756	93	29572674
IVth nerve paresis	21.36	20.52	3	1757	12	29572755

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Violence-related symptom	34.91	18.83	8	3488	687	64494549
Morbid thoughts	24.21	18.83	6	3490	720	64494516
Mesothelioma	23.01	18.83	5	3491	337	64494899
Coma scale abnormal	22.10	18.83	10	3486	7764	64487472
Hyponatraemia	20.32	18.83	32	3464	148307	64346929
Agitation	19.52	18.83	24	3472	88343	64406893
Myeloid maturation arrest	19.02	18.83	3	3493	33	64495203

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A02AA01	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS ANTACIDS Magnesium compounds
ATC	A06AD01	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Osmotically acting laxatives
MeSH PA	D057886	Bleaching Agents
MeSH PA	D058427	Hygroscopic Agents
MeSH PA	D016877	Oxidants
CHEBI has role	CHEBI:33287	fertilizers
CHEBI has role	CHEBI:65265	antacids

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Peptic ulcer	indication	13200003	DOID:750
Constipation	indication	14760008	DOID:2089
Heartburn	indication	16331000
Indigestion	indication	162031009
Hypomagnesemia	indication	190855004
Gastroesophageal reflux disease	indication	235595009	DOID:8534
Incomplete passage of stool	indication	249515001
Struvite Renal Calculi	indication
Calcium Phosphate Renal Calculi	indication
Hiatal Hernia with Reflux Esophagitis	indication
Gastric Hypersecretory Conditions	indication
Hypocalcemia	off-label use	5291005
Multiple endocrine adenomas	off-label use	60549007
Osteoporosis	off-label use	64859006	DOID:11476
Postmenopausal osteoporosis	off-label use	102447009
Systemic mast cell disease	off-label use	397016004	DOID:349
Stress-Related GI Mucosal Bleeding Prevention	off-label use
Renal Osteodystrophy with Hyperphosphatemia	off-label use
Hypophosphatemia	contraindication	4996001
Suicidal thoughts	contraindication	6471006
Alcoholism	contraindication	7200002
Hyperammonemia	contraindication	9360008
Hepatic encephalopathy	contraindication	13920009	DOID:13413
Sarcoidosis	contraindication	31541009	DOID:11335
Dehydration	contraindication	34095006
Depressive disorder	contraindication	35489007
Fecal impaction	contraindication	44635007
Hepatic failure	contraindication	59927004
Diarrhea	contraindication	62315008
Poisoning by phenobarbital	contraindication	64921004
Substance abuse	contraindication	66214007
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Hemorrhoids	contraindication	70153002	DOID:9746
Hypercalciuria	contraindication	71938000
Hepatic coma	contraindication	72836002	DOID:12550
Sleep apnea	contraindication	73430006	DOID:0050847
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007
Gastrointestinal obstruction	contraindication	126765001
Osteolysis	contraindication	203522001
Disease of liver	contraindication	235856003	DOID:409
Chronic diarrhea	contraindication	236071009
Aluminum intoxication	contraindication	236546003
Dyspnea	contraindication	267036007
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Neutropenic disorder	contraindication	303011007	DOID:1227
Breastfeeding (mother)	contraindication	413712001
Porphyria	contraindication	418470004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4017631	VUID
N0000146011	NUI
D01446	KEGG_DRUG
4017631	VANDF
C0065517	UMLSCUI
CHEBI:31793	CHEBI
CHEMBL1200736	ChEMBL_ID
DB09481	DRUGBANK_ID
C005479	MESH_SUPPLEMENTAL_RECORD_UI
0E53J927NA	UNII
11029	PUBCHEM_CID
29155	RXNORM
29720	MMSL
5008	MMSL
5560	MMSL
d03588	MMSL
000785	NDDF
001120	NDDF
007230	NDDF
387401007	SNOMEDCT_US
7168001	SNOMEDCT_US
17968-26-2	SECONDARY_CAS_RN

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
GAVISCON	HUMAN OTC DRUG LABEL	2	0135-0094	LIQUID	358 mg	ORAL	OTC monograph final	13 sections
GAVISCON	HUMAN OTC DRUG LABEL	2	0135-0095	LIQUID	237.50 mg	ORAL	OTC monograph final	13 sections
GavisconExtra Strength	HUMAN OTC DRUG LABEL	2	0135-0098	TABLET, CHEWABLE	105 mg	ORAL	OTC monograph final	15 sections
GavisconExtra Strength	HUMAN OTC DRUG LABEL	2	0135-0430	TABLET, CHEWABLE	105 mg	ORAL	OTC monograph final	15 sections
GAVISCON	HUMAN OTC DRUG LABEL	2	0135-0574	LIQUID	237.50 mg	ORAL	OTC monograph final	13 sections
Renacidin	HUMAN PRESCRIPTION DRUG LABEL	3	0327-0012	SOLUTION	3.27 g	IRRIGATION	NDA	14 sections
FAST ACTING Heartburn Relief	HUMAN OTC DRUG LABEL	2	0363-1155	TABLET, CHEWABLE	105 mg	ORAL	OTC monograph final	12 sections
Walgreens Fast Acting Heartburn Relief Extra Strength	HUMAN OTC DRUG LABEL	2	0363-7630	LIQUID	237.50 mg	ORAL	OTC monograph final	13 sections
Humco Dewees Carminative	HUMAN OTC DRUG LABEL	1	0395-0713	SUSPENSION	50 mg	ORAL	OTC monograph final	12 sections
Humco Dewees Carminative	HUMAN OTC DRUG LABEL	1	0395-0713	SUSPENSION	50 mg	ORAL	OTC monograph final	12 sections
Acid Gone AntacidExtra Strength	HUMAN OTC DRUG LABEL	2	0904-5365	TABLET, CHEWABLE	105 mg	ORAL	OTC monograph final	12 sections
ACID GONE ANTACID	HUMAN OTC DRUG LABEL	2	0904-7727	LIQUID	358 mg	ORAL	OTC monograph final	10 sections
Extra StrengthAntacid	HUMAN OTC DRUG LABEL	2	11673-814	TABLET, CHEWABLE	105 mg	ORAL	OTC monograph final	12 sections
Rite Aid Extra Strength	HUMAN OTC DRUG LABEL	2	11822-1051	TABLET, CHEWABLE	105 mg	ORAL	OTC monograph final	12 sections
EXTRA STRENGTH HEARTBURN RELIEF ANTACID	HUMAN OTC DRUG LABEL	2	11822-6862	SUSPENSION	237.50 mg	ORAL	OTC monograph final	10 sections
Kroger Extra Strength	HUMAN OTC DRUG LABEL	2	30142-610	TABLET, CHEWABLE	105 mg	ORAL	OTC monograph final	12 sections
HEB Extra StrengthOriginal Flavor	HUMAN OTC DRUG LABEL	2	37808-505	TABLET, CHEWABLE	105 mg	ORAL	OTC monograph final	12 sections
HEB Extra StrengthCherry Flavor	HUMAN OTC DRUG LABEL	2	37808-510	TABLET, CHEWABLE	105 mg	ORAL	OTC monograph final	12 sections
HEB Extra StrengthCool Mint	HUMAN OTC DRUG LABEL	2	37808-632	LIQUID	237.50 mg	ORAL	OTC monograph final	13 sections
Meijer Extra StrengthOriginal Flavor	HUMAN OTC DRUG LABEL	2	41250-675	TABLET, CHEWABLE	105 mg	ORAL	OTC monograph final	12 sections
Stomachin Antacid	HUMAN OTC DRUG LABEL	2	43337-9328	CAPSULE	58 mg	ORAL	OTC monograph not final	10 sections
Stomachin Antacid	HUMAN OTC DRUG LABEL	2	43337-9328	CAPSULE	58 mg	ORAL	OTC monograph not final	10 sections
Stomachin Antacid	HUMAN OTC DRUG LABEL	2	43337-9329	POWDER	58 mg	ORAL	OTC monograph final	15 sections
GOOD NEIGHBOR PHARMACY Antacid Extra Strength	HUMAN OTC DRUG LABEL	2	46122-150	TABLET, CHEWABLE	105 mg	ORAL	OTC monograph final	12 sections
equate Extra Strength Antacid	HUMAN OTC DRUG LABEL	2	49035-105	TABLET, CHEWABLE	105 mg	ORAL	OTC monograph final	12 sections
INON	HUMAN OTC DRUG LABEL	3	49873-045	GRANULE	400 mg	ORAL	OTC monograph final	13 sections
SohMed Acid Reducer	HUMAN OTC DRUG LABEL	2	50405-002	TABLET, CHEWABLE	105 mg	ORAL	OTC MONOGRAPH FINAL	14 sections
Riginic Antacid Liquid	HUMAN OTC DRUG LABEL	2	53807-137	LIQUID	358 mg	ORAL	OTC monograph final	13 sections
Estomarol	HUMAN OTC DRUG LABEL	5	57465-100	POWDER	0.59 g	ORAL	OTC monograph final	10 sections
MagneBind 400 Rx	HUMAN PRESCRIPTION DRUG LABEL	3	59528-0416	TABLET, FILM COATED	115 mg	oral	unapproved drug other	4 sections