magnesium carbonate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4288 546-93-0

Description:

MoleculeDescription

Synonyms:

  • magnesium carbonate
  • carbonic acid magnesium salt
  • Molecular weight: 84.31
  • Formula: CMgO3
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
7 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 2, 1990 FDA UNITED GUARDIAN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Vaginal flatulence 62.79 14.43 19 5006 3274 63480723
Proctitis 57.23 14.43 20 5005 5421 63478576
Radiculopathy 48.30 14.43 20 5005 8591 63475406
Female genital tract fistula 47.34 14.43 19 5006 7540 63476457
Vaginal discharge 43.74 14.43 19 5006 9179 63474818
Chronic sinusitis 37.68 14.43 19 5006 12824 63471173
Colitis 35.57 14.43 30 4995 48498 63435499
Paraesthesia oral 33.05 14.43 20 5005 19236 63464761
Frequent bowel movements 32.19 14.43 21 5004 23001 63460996
Macular degeneration 31.10 14.43 21 5004 24355 63459642
Oral candidiasis 29.95 14.43 20 5005 22778 63461219
Colitis ulcerative 29.81 14.43 21 5004 26070 63457927
Procedural pain 28.52 14.43 19 5006 21550 63462447
Hyponatraemia 24.84 14.43 37 4988 111863 63372134
Morbid thoughts 22.86 14.43 6 5019 617 63483380
Epilepsy 22.48 14.43 18 5007 27047 63456950
Coma scale abnormal 22.41 14.43 10 5015 5143 63478854
Rectal haemorrhage 21.85 14.43 23 5002 49007 63434990
Periventricular leukomalacia 19.83 14.43 4 5021 127 63483870
Anaemia 19.36 14.43 59 4966 293371 63190626
Dyspepsia 17.46 14.43 30 4995 102166 63381831
Haematochezia 16.88 14.43 21 5004 53523 63430474
Agitation 16.58 14.43 22 5003 59735 63424262
Jaundice neonatal 16.20 14.43 5 5020 920 63483077
Maternal drugs affecting foetus 16.09 14.43 8 5017 5234 63478763
Abdominal pain 15.74 14.43 55 4970 293401 63190596
Confusional state 15.08 14.43 47 4978 236333 63247664
Melaena 14.89 14.43 15 5010 30350 63453647
Hypertriglyceridaemia 14.76 14.43 8 5017 6251 63477746
Acute kidney injury 14.67 14.43 50 4975 263365 63220632

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood phosphorus increased 72.15 20.48 27 3176 7694 34946034
Appendicolith 69.31 20.48 27 3176 8574 34945154
Appendicitis 61.28 20.48 29 3174 14778 34938950
Myasthenia gravis 49.66 20.48 20 3183 6920 34946808
Cardiogenic shock 47.85 20.48 30 3173 26588 34927140
Ventricular fibrillation 46.69 20.48 28 3175 22926 34930802
Blood uric acid increased 46.52 20.48 21 3182 9603 34944125
Mesothelioma 45.08 20.48 10 3193 435 34953293
Dry mouth 44.42 20.48 30 3173 30135 34923593
Stress 39.55 20.48 28 3175 30319 34923409
Abdominal distension 38.07 20.48 36 3167 58456 34895272
Hyponatraemia 32.63 20.48 39 3164 82652 34871076
Blood cholesterol increased 31.59 20.48 21 3182 20522 34933206
Multiple organ dysfunction syndrome 28.39 20.48 35 3168 76531 34877197
Vomiting 27.46 20.48 66 3137 247555 34706173
Ascites 27.16 20.48 27 3176 46544 34907184
Hyperphosphataemia 25.70 20.48 11 3192 4426 34949302
Incorrect route of product administration 24.83 20.48 16 3187 14829 34938899
General physical health deterioration 24.68 20.48 43 3160 128226 34825502
Analgesic therapy 23.46 20.48 7 3196 991 34952737
Sleep disorder therapy 23.29 20.48 7 3196 1016 34952712
Abdominal pain 23.02 20.48 48 3155 163570 34790158
Violence-related symptom 22.89 20.48 6 3197 530 34953198
Drug therapy 22.54 20.48 7 3196 1134 34952594
Somnolence 21.04 20.48 37 3166 111079 34842649
Iron deficiency 20.61 20.48 10 3193 5371 34948357

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 71.88 14.95 27 6624 8524 79729213
Blood phosphorus increased 70.35 14.95 28 6623 10319 79727418
Vaginal flatulence 61.95 14.95 18 6633 2557 79735180
Appendicitis 57.31 14.95 30 6621 20764 79716973
Proctitis 49.34 14.95 19 6632 6413 79731324
Hyponatraemia 49.06 14.95 67 6584 177781 79559956
Female genital tract fistula 47.09 14.95 18 6633 5957 79731780
Blood uric acid increased 44.77 14.95 22 6629 13338 79724399
Myasthenia gravis 43.66 14.95 20 6631 10379 79727358
Radiculopathy 43.53 14.95 19 6632 8805 79728932
Vaginal discharge 43.21 14.95 18 6633 7445 79730292
Ventricular fibrillation 42.97 14.95 29 6622 31897 79705840
Macular degeneration 36.06 14.95 18 6633 11278 79726459
Cardiogenic shock 35.90 14.95 29 6622 41885 79695852
Abdominal distension 32.85 14.95 45 6606 119605 79618132
Dry mouth 31.89 14.95 38 6613 87981 79649756
Violence-related symptom 31.08 14.95 8 6643 723 79737014
Chronic sinusitis 30.86 14.95 17 6634 13009 79724728
Abdominal pain 28.48 14.95 84 6567 389485 79348252
Incorrect route of product administration 27.47 14.95 23 6628 34906 79702831
Oral candidiasis 26.43 14.95 21 6630 29607 79708130
Paraesthesia oral 26.13 14.95 18 6633 20453 79717284
Colitis 25.49 14.95 31 6620 73276 79664461
Stress 25.01 14.95 32 6619 79580 79658157
Frequent bowel movements 24.37 14.95 20 6631 29519 79708218
Procedural pain 24.18 14.95 18 6633 23066 79714671
Analgesic therapy 24.04 14.95 7 6644 1002 79736735
Sleep disorder therapy 23.93 14.95 7 6644 1017 79736720
Colitis ulcerative 23.52 14.95 21 6630 34721 79703016
Hyperphosphataemia 22.86 14.95 11 6640 6365 79731372
Drug therapy 22.83 14.95 7 6644 1194 79736543
General physical health deterioration 21.68 14.95 61 6590 275177 79462560
Morbid thoughts 21.05 14.95 6 6645 796 79736941
Mesothelioma 20.55 14.95 5 6646 359 79737378
Multiple organ dysfunction syndrome 20.09 14.95 36 6615 120210 79617527
Vomiting 19.58 14.95 108 6543 665720 79072017
Blood cholesterol increased 19.31 14.95 29 6622 83691 79654046
Somnolence 18.85 14.95 53 6598 238928 79498809
Glomerular filtration rate 18.83 14.95 4 6647 156 79737581
Epilepsy 18.82 14.95 20 6631 40840 79696897
Ascites 18.62 14.95 27 6624 75535 79662202
Iron deficiency 17.57 14.95 11 6640 10643 79727094
Dyspepsia 17.47 14.95 32 6619 108655 79629082
Myeloid maturation arrest 16.99 14.95 3 6648 43 79737694
Coma scale abnormal 16.99 14.95 10 6641 8668 79729069

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02AA01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
ANTACIDS
Magnesium compounds
ATC A06AD01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Osmotically acting laxatives
MeSH PA D057886 Bleaching Agents
MeSH PA D058427 Hygroscopic Agents
MeSH PA D016877 Oxidants
CHEBI has role CHEBI:33287 fertilizers
CHEBI has role CHEBI:65265 antacids

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Constipation indication 14760008 DOID:2089
Heartburn indication 16331000
Indigestion indication 162031009
Hypomagnesemia indication 190855004
Gastroesophageal reflux disease indication 235595009 DOID:8534
Incomplete passage of stool indication 249515001
Struvite Renal Calculi indication
Calcium Phosphate Renal Calculi indication
Hiatal Hernia with Reflux Esophagitis indication
Gastric Hypersecretory Conditions indication
Hypocalcemia off-label use 5291005
Multiple endocrine adenomas off-label use 60549007
Osteoporosis off-label use 64859006 DOID:11476
Postmenopausal osteoporosis off-label use 102447009
Systemic mast cell disease off-label use 397016004 DOID:349
Stress-Related GI Mucosal Bleeding Prevention off-label use
Renal Osteodystrophy with Hyperphosphatemia off-label use
Hypophosphatemia contraindication 4996001
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Hyperammonemia contraindication 9360008
Hepatic encephalopathy contraindication 13920009 DOID:13413
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Fecal impaction contraindication 44635007
Hepatic failure contraindication 59927004
Diarrhea contraindication 62315008
Poisoning by phenobarbital contraindication 64921004
Substance abuse contraindication 66214007
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hemorrhoids contraindication 70153002 DOID:9746
Hypercalciuria contraindication 71938000
Hepatic coma contraindication 72836002 DOID:12550
Sleep apnea contraindication 73430006 DOID:0050847
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Gastrointestinal obstruction contraindication 126765001
Osteolysis contraindication 203522001
Disease of liver contraindication 235856003 DOID:409
Chronic diarrhea contraindication 236071009
Aluminum intoxication contraindication 236546003
Dyspnea contraindication 267036007
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Breastfeeding (mother) contraindication 413712001
Porphyria contraindication 418470004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017631 VUID
N0000146011 NUI
D01446 KEGG_DRUG
4017631 VANDF
C0065517 UMLSCUI
CHEBI:31793 CHEBI
CHEMBL1200736 ChEMBL_ID
DB09481 DRUGBANK_ID
C005479 MESH_SUPPLEMENTAL_RECORD_UI
0E53J927NA UNII
11029 PUBCHEM_CID
29155 RXNORM
29720 MMSL
5008 MMSL
5560 MMSL
d03588 MMSL
000785 NDDF
001120 NDDF
007230 NDDF
387401007 SNOMEDCT_US
7168001 SNOMEDCT_US
17968-26-2 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
GAVISCON HUMAN OTC DRUG LABEL 2 0135-0094 LIQUID 358 mg ORAL OTC monograph final 13 sections
GAVISCON HUMAN OTC DRUG LABEL 2 0135-0095 LIQUID 237.50 mg ORAL OTC monograph final 13 sections
GavisconExtra Strength HUMAN OTC DRUG LABEL 2 0135-0098 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 15 sections
GavisconExtra Strength HUMAN OTC DRUG LABEL 2 0135-0098 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 15 sections
GavisconExtra Strength HUMAN OTC DRUG LABEL 2 0135-0430 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 15 sections
GavisconExtra Strength HUMAN OTC DRUG LABEL 2 0135-0430 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 15 sections
GAVISCON HUMAN OTC DRUG LABEL 2 0135-0574 LIQUID 237.50 mg ORAL OTC monograph final 13 sections
Renacidin HUMAN PRESCRIPTION DRUG LABEL 3 0327-0012 SOLUTION 3.27 g IRRIGATION NDA 14 sections
FAST ACTING Heartburn Relief HUMAN OTC DRUG LABEL 2 0363-1155 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 12 sections
FAST ACTING Heartburn Relief HUMAN OTC DRUG LABEL 2 0363-1155 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 12 sections
Walgreens Fast Acting Heartburn Relief Extra Strength HUMAN OTC DRUG LABEL 2 0363-7630 LIQUID 237.50 mg ORAL OTC monograph final 13 sections
Walgreens Fast Acting Heartburn Relief Extra Strength HUMAN OTC DRUG LABEL 2 0363-7630 LIQUID 237.50 mg ORAL OTC monograph final 13 sections
Humco Dewees Carminative HUMAN OTC DRUG LABEL 1 0395-0713 SUSPENSION 50 mg ORAL OTC monograph final 12 sections
Humco Dewees Carminative HUMAN OTC DRUG LABEL 1 0395-0713 SUSPENSION 50 mg ORAL OTC monograph final 12 sections
Acid Gone AntacidExtra Strength HUMAN OTC DRUG LABEL 2 0904-5365 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 12 sections
Acid Gone AntacidExtra Strength HUMAN OTC DRUG LABEL 2 0904-5365 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 12 sections
ACID GONE ANTACID HUMAN OTC DRUG LABEL 2 0904-7727 LIQUID 358 mg ORAL OTC monograph final 10 sections
Extra StrengthAntacid HUMAN OTC DRUG LABEL 2 11673-814 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 12 sections
Extra StrengthAntacid HUMAN OTC DRUG LABEL 2 11673-814 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 12 sections
Rite Aid Extra Strength HUMAN OTC DRUG LABEL 2 11822-1050 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 12 sections
Rite Aid Extra Strength HUMAN OTC DRUG LABEL 2 11822-1051 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 12 sections
Rite Aid Extra Strength HUMAN OTC DRUG LABEL 2 11822-1051 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 12 sections
EXTRA STRENGTH HEARTBURN RELIEF ANTACID HUMAN OTC DRUG LABEL 2 11822-6862 SUSPENSION 237.50 mg ORAL OTC monograph final 10 sections
Kroger Extra Strength HUMAN OTC DRUG LABEL 2 30142-610 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 12 sections
Kroger Extra Strength HUMAN OTC DRUG LABEL 2 30142-610 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 12 sections
Kroger Extra Strength HUMAN OTC DRUG LABEL 2 30142-610 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 12 sections
HEB Extra StrengthOriginal Flavor HUMAN OTC DRUG LABEL 2 37808-505 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 12 sections
HEB Extra StrengthOriginal Flavor HUMAN OTC DRUG LABEL 2 37808-505 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 12 sections
HEB Extra StrengthCherry Flavor HUMAN OTC DRUG LABEL 2 37808-510 TABLET, CHEWABLE 105 mg ORAL OTC monograph final 12 sections
HEB Extra StrengthCool Mint HUMAN OTC DRUG LABEL 2 37808-632 LIQUID 237.50 mg ORAL OTC monograph final 13 sections