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docusate sodium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 941 | 10041-19-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.15 | g | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 | 55 | |||
| kinase-selectivity-class | AXL,EPHB4,GRK2,MAP2K6,STK33,TEK | 6 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Constipation | 584.23 | 9.62 | 1226 | 122870 | 279169 | 90225182 |
| Systemic lupus erythematosus | 409.06 | 9.62 | 21 | 124075 | 361875 | 90142476 |
| Pemphigus | 404.19 | 9.62 | 9 | 124087 | 326855 | 90177496 |
| Hand deformity | 371.03 | 9.62 | 7 | 124089 | 296355 | 90207996 |
| Glossodynia | 312.61 | 9.62 | 37 | 124059 | 321742 | 90182609 |
| Synovitis | 303.42 | 9.62 | 45 | 124051 | 329707 | 90174644 |
| Drug ineffective | 286.67 | 9.62 | 959 | 123137 | 1383339 | 89121012 |
| Duodenal ulcer perforation | 282.06 | 9.62 | 4 | 124092 | 221284 | 90283067 |
| Helicobacter infection | 256.72 | 9.62 | 13 | 124083 | 226837 | 90277514 |
| Folliculitis | 243.68 | 9.62 | 8 | 124088 | 204345 | 90300006 |
| Pericarditis | 236.97 | 9.62 | 42 | 124054 | 270109 | 90234242 |
| Pneumonia aspiration | 236.34 | 9.62 | 286 | 123810 | 40654 | 90463697 |
| Food allergy | 235.05 | 9.62 | 228 | 123868 | 25250 | 90479101 |
| Wound | 231.74 | 9.62 | 64 | 124032 | 302916 | 90201435 |
| Muscle injury | 225.95 | 9.62 | 3 | 124093 | 176651 | 90327700 |
| Back pain | 211.91 | 9.62 | 928 | 123168 | 316247 | 90188104 |
| Arthropathy | 209.04 | 9.62 | 121 | 123975 | 366121 | 90138230 |
| Temperature regulation disorder | 207.78 | 9.62 | 167 | 123929 | 14412 | 90489939 |
| Therapeutic product effect decreased | 206.06 | 9.62 | 62 | 124034 | 277509 | 90226842 |
| Discomfort | 204.16 | 9.62 | 61 | 124035 | 274274 | 90230077 |
| Maternal exposure during pregnancy | 199.81 | 9.62 | 123 | 123973 | 359940 | 90144411 |
| Swelling | 172.20 | 9.62 | 192 | 123904 | 418866 | 90085485 |
| Irritable bowel syndrome | 171.89 | 9.62 | 37 | 124059 | 207411 | 90296940 |
| Urinary tract infection | 171.53 | 9.62 | 850 | 123246 | 304782 | 90199569 |
| Immunodeficiency | 166.61 | 9.62 | 248 | 123848 | 42986 | 90461365 |
| Liver injury | 162.15 | 9.62 | 21 | 124075 | 170546 | 90333805 |
| C-reactive protein abnormal | 159.42 | 9.62 | 3 | 124093 | 127426 | 90376925 |
| Psoriatic arthropathy | 155.53 | 9.62 | 59 | 124037 | 228276 | 90276075 |
| Sleep disorder due to general medical condition, insomnia type | 150.06 | 9.62 | 6 | 124090 | 128688 | 90375663 |
| Impaired healing | 145.93 | 9.62 | 69 | 124027 | 234130 | 90270221 |
| Type 2 diabetes mellitus | 144.40 | 9.62 | 49 | 124047 | 203195 | 90301156 |
| Alopecia | 142.26 | 9.62 | 290 | 123806 | 494781 | 90009570 |
| Pulmonary embolism | 141.18 | 9.62 | 447 | 123649 | 130373 | 90373978 |
| Swollen joint count increased | 137.58 | 9.62 | 3 | 124093 | 111203 | 90393148 |
| Foetal death | 131.55 | 9.62 | 152 | 123944 | 20571 | 90483780 |
| Blister | 125.64 | 9.62 | 99 | 123997 | 254899 | 90249452 |
| Abdominal discomfort | 122.06 | 9.62 | 298 | 123798 | 477030 | 90027321 |
| Death | 120.89 | 9.62 | 1051 | 123045 | 455500 | 90048851 |
| Deep vein thrombosis | 119.67 | 9.62 | 335 | 123761 | 91285 | 90413066 |
| Plasma cell myeloma | 118.67 | 9.62 | 206 | 123890 | 40622 | 90463729 |
| Hyperhidrosis | 118.28 | 9.62 | 433 | 123663 | 135872 | 90368479 |
| Somnolence | 114.71 | 9.62 | 578 | 123518 | 208506 | 90295845 |
| General physical health deterioration | 114.34 | 9.62 | 194 | 123902 | 354921 | 90149430 |
| Mental status changes | 113.99 | 9.62 | 213 | 123883 | 44466 | 90459885 |
| Completed suicide | 113.94 | 9.62 | 29 | 124067 | 145029 | 90359322 |
| Lip dry | 113.48 | 9.62 | 6 | 124090 | 100949 | 90403402 |
| C-reactive protein increased | 107.62 | 9.62 | 57 | 124039 | 181332 | 90323019 |
| Facet joint syndrome | 107.09 | 9.62 | 7 | 124089 | 98382 | 90405969 |
| Fluid retention | 105.28 | 9.62 | 312 | 123784 | 87779 | 90416572 |
| Gastrooesophageal reflux disease | 105.11 | 9.62 | 479 | 123617 | 165858 | 90338493 |
| Upper respiratory tract infection | 104.97 | 9.62 | 400 | 123696 | 127918 | 90376433 |
| Condition aggravated | 104.57 | 9.62 | 440 | 123656 | 595105 | 89909246 |
| Dehydration | 102.09 | 9.62 | 531 | 123565 | 193916 | 90310435 |
| Ill-defined disorder | 101.30 | 9.62 | 64 | 124032 | 184827 | 90319524 |
| Fall | 101.12 | 9.62 | 1056 | 123040 | 480754 | 90023597 |
| Blood cholesterol increased | 98.42 | 9.62 | 84 | 124012 | 207928 | 90296423 |
| Grip strength decreased | 96.72 | 9.62 | 8 | 124088 | 92568 | 90411783 |
| Contraindicated product administered | 93.16 | 9.62 | 186 | 123910 | 319953 | 90184398 |
| Pulmonary malformation | 91.39 | 9.62 | 30 | 124066 | 360 | 90503991 |
| Pleural effusion | 90.69 | 9.62 | 348 | 123748 | 111643 | 90392708 |
| Gastrointestinal disorder | 88.45 | 9.62 | 134 | 123962 | 256553 | 90247798 |
| Total lung capacity decreased | 87.13 | 9.62 | 58 | 124038 | 3737 | 90500614 |
| Coma | 84.65 | 9.62 | 255 | 123841 | 72377 | 90431974 |
| Febrile neutropenia | 84.19 | 9.62 | 434 | 123662 | 157915 | 90346436 |
| Salpingo-oophorectomy unilateral | 80.91 | 9.62 | 35 | 124061 | 933 | 90503418 |
| Urticaria | 79.26 | 9.62 | 196 | 123900 | 312538 | 90191813 |
| Rash erythematous | 79.13 | 9.62 | 232 | 123864 | 64872 | 90439479 |
| Fibromyalgia | 78.75 | 9.62 | 100 | 123996 | 206169 | 90298182 |
| Live birth | 76.97 | 9.62 | 9 | 124087 | 79098 | 90425253 |
| Sinusitis fungal | 76.13 | 9.62 | 42 | 124054 | 1922 | 90502429 |
| Bronchopulmonary aspergillosis allergic | 75.66 | 9.62 | 53 | 124043 | 3713 | 90500638 |
| Hypoxia | 74.99 | 9.62 | 244 | 123852 | 72155 | 90432196 |
| Stomatitis | 73.72 | 9.62 | 167 | 123929 | 274531 | 90229820 |
| Joint range of motion decreased | 72.86 | 9.62 | 48 | 124048 | 135595 | 90368756 |
| Hypercholesterolaemia | 72.20 | 9.62 | 24 | 124072 | 100868 | 90403483 |
| Red blood cell sedimentation rate increased | 72.01 | 9.62 | 13 | 124083 | 82582 | 90421769 |
| Mobility decreased | 71.79 | 9.62 | 147 | 123949 | 250587 | 90253764 |
| Peripheral venous disease | 71.48 | 9.62 | 14 | 124082 | 83907 | 90420444 |
| Inflammation | 70.89 | 9.62 | 84 | 124012 | 178508 | 90325843 |
| Blood calcium increased | 70.81 | 9.62 | 85 | 124011 | 11973 | 90492378 |
| Lung opacity | 70.63 | 9.62 | 62 | 124034 | 6040 | 90498311 |
| Embolism venous | 70.53 | 9.62 | 50 | 124046 | 3570 | 90500781 |
| Cardiac failure congestive | 68.98 | 9.62 | 293 | 123803 | 98401 | 90405950 |
| Therapeutic product effect incomplete | 68.95 | 9.62 | 99 | 123997 | 193797 | 90310554 |
| Drug intolerance | 68.78 | 9.62 | 347 | 123749 | 447244 | 90057107 |
| Asthenia | 67.30 | 9.62 | 1065 | 123031 | 532686 | 89971665 |
| Haemoglobin decreased | 66.98 | 9.62 | 415 | 123681 | 161541 | 90342810 |
| Sputum increased | 65.03 | 9.62 | 44 | 124052 | 2913 | 90501438 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 63.93 | 9.62 | 49 | 124047 | 3944 | 90500407 |
| Sleep disorder | 63.85 | 9.62 | 108 | 123988 | 197922 | 90306429 |
| Epilepsy | 63.47 | 9.62 | 17 | 124079 | 82189 | 90422162 |
| Intentional product misuse | 63.39 | 9.62 | 267 | 123829 | 89337 | 90415014 |
| Lung cyst | 63.25 | 9.62 | 24 | 124072 | 451 | 90503900 |
| Blepharospasm | 63.25 | 9.62 | 3 | 124093 | 55442 | 90448909 |
| Diverticulum | 62.48 | 9.62 | 80 | 124016 | 12033 | 90492318 |
| Hiatus hernia | 62.32 | 9.62 | 119 | 123977 | 25242 | 90479109 |
| Oedema peripheral | 61.61 | 9.62 | 581 | 123515 | 257334 | 90247017 |
| Dislocation of vertebra | 60.85 | 9.62 | 4 | 124092 | 55964 | 90448387 |
| Intentional product use issue | 60.53 | 9.62 | 129 | 123967 | 216763 | 90287588 |
| Nausea | 59.25 | 9.62 | 1961 | 122135 | 1108355 | 89395996 |
| Pneumonia | 59.18 | 9.62 | 1213 | 122883 | 636846 | 89867505 |
| Diastolic dysfunction | 59.11 | 9.62 | 61 | 124035 | 7272 | 90497079 |
| Adjustment disorder with depressed mood | 59.01 | 9.62 | 5 | 124091 | 56748 | 90447603 |
| Hospice care | 57.96 | 9.62 | 69 | 124027 | 9635 | 90494716 |
| Night sweats | 56.15 | 9.62 | 56 | 124040 | 128710 | 90375641 |
| Obesity | 55.77 | 9.62 | 38 | 124058 | 105469 | 90398882 |
| Abdominal pain | 55.39 | 9.62 | 804 | 123292 | 394917 | 90109434 |
| Wound infection | 55.34 | 9.62 | 39 | 124057 | 106363 | 90397988 |
| Hypotension | 54.97 | 9.62 | 684 | 123412 | 324713 | 90179638 |
| Full blood count decreased | 54.97 | 9.62 | 124 | 123972 | 29565 | 90474786 |
| Intentional overdose | 54.89 | 9.62 | 30 | 124066 | 93804 | 90410547 |
| Joint swelling | 54.73 | 9.62 | 434 | 123662 | 502866 | 90001485 |
| Obstructive airways disorder | 54.70 | 9.62 | 114 | 123982 | 25755 | 90478596 |
| Arthralgia | 54.14 | 9.62 | 746 | 123350 | 777776 | 89726575 |
| Treatment failure | 52.94 | 9.62 | 225 | 123871 | 303703 | 90200648 |
| Tricuspid valve incompetence | 52.02 | 9.62 | 87 | 124009 | 16644 | 90487707 |
| Autoimmune disorder | 51.93 | 9.62 | 20 | 124076 | 76724 | 90427627 |
| White blood cell count decreased | 51.79 | 9.62 | 399 | 123697 | 166710 | 90337641 |
| Off label use | 51.67 | 9.62 | 1134 | 122962 | 1101118 | 89403233 |
| Respiratory tract malformation | 50.76 | 9.62 | 16 | 124080 | 167 | 90504184 |
| Pleuritic pain | 50.70 | 9.62 | 67 | 124029 | 10394 | 90493957 |
| Aspiration | 50.67 | 9.62 | 83 | 124013 | 15610 | 90488741 |
| Therapy non-responder | 50.39 | 9.62 | 68 | 124028 | 136636 | 90367715 |
| Lethargy | 50.11 | 9.62 | 195 | 123901 | 62944 | 90441407 |
| Fungal infection | 48.97 | 9.62 | 149 | 123947 | 42512 | 90461839 |
| Respiratory symptom | 48.81 | 9.62 | 43 | 124053 | 4209 | 90500142 |
| Anaemia | 48.65 | 9.62 | 715 | 123381 | 352087 | 90152264 |
| Small intestinal obstruction | 47.76 | 9.62 | 96 | 124000 | 21138 | 90483213 |
| Hyponatraemia | 47.19 | 9.62 | 329 | 123767 | 133209 | 90371142 |
| Balance disorder | 46.75 | 9.62 | 259 | 123837 | 96821 | 90407530 |
| Product use in unapproved indication | 46.46 | 9.62 | 270 | 123826 | 335966 | 90168385 |
| Fatigue | 45.85 | 9.62 | 1973 | 122123 | 1152050 | 89352301 |
| Lung disorder | 45.36 | 9.62 | 85 | 124011 | 149798 | 90354553 |
| Bone erosion | 44.83 | 9.62 | 9 | 124087 | 53012 | 90451339 |
| Adverse event | 44.71 | 9.62 | 57 | 124039 | 117361 | 90386990 |
| Renal function test abnormal | 44.39 | 9.62 | 52 | 124044 | 7139 | 90497212 |
| Tremor | 44.32 | 9.62 | 360 | 123736 | 152813 | 90351538 |
| Nail disorder | 44.13 | 9.62 | 13 | 124083 | 59054 | 90445297 |
| Failure to thrive | 44.09 | 9.62 | 56 | 124040 | 8355 | 90495996 |
| Coeliac disease | 44.09 | 9.62 | 148 | 123948 | 44462 | 90459889 |
| Injection site reaction | 43.75 | 9.62 | 37 | 124059 | 92043 | 90412308 |
| Creatinine renal clearance increased | 43.42 | 9.62 | 36 | 124060 | 3245 | 90501106 |
| Carbuncle | 43.10 | 9.62 | 26 | 124070 | 1410 | 90502941 |
| Onychomadesis | 42.89 | 9.62 | 6 | 124090 | 45992 | 90458359 |
| Dyspnoea | 42.87 | 9.62 | 1540 | 122556 | 879415 | 89624936 |
| Intestinal pseudo-obstruction | 42.70 | 9.62 | 24 | 124072 | 1139 | 90503212 |
| Overdose | 42.61 | 9.62 | 365 | 123731 | 157344 | 90347007 |
| Lupus-like syndrome | 41.91 | 9.62 | 8 | 124088 | 48838 | 90455513 |
| Emphysema | 41.58 | 9.62 | 66 | 124030 | 12089 | 90492262 |
| Cellulitis | 41.55 | 9.62 | 240 | 123856 | 91097 | 90413254 |
| Myelosuppression | 41.52 | 9.62 | 11 | 124085 | 53580 | 90450771 |
| Atrial fibrillation | 41.38 | 9.62 | 319 | 123777 | 133292 | 90371059 |
| Blood potassium decreased | 40.84 | 9.62 | 151 | 123945 | 47576 | 90456775 |
| Monoclonal immunoglobulin present | 40.60 | 9.62 | 29 | 124067 | 2095 | 90502256 |
| Road traffic accident | 40.21 | 9.62 | 53 | 124043 | 107573 | 90396778 |
| Infection | 39.90 | 9.62 | 311 | 123785 | 361783 | 90142568 |
| Rales | 39.79 | 9.62 | 75 | 124021 | 15752 | 90488599 |
| Hip arthroplasty | 39.54 | 9.62 | 28 | 124068 | 76180 | 90428171 |
| Hip fracture | 39.35 | 9.62 | 117 | 123979 | 32960 | 90471391 |
| Gait inability | 39.29 | 9.62 | 89 | 124007 | 146367 | 90357984 |
| Cestode infection | 38.71 | 9.62 | 15 | 124081 | 299 | 90504052 |
| Musculoskeletal stiffness | 38.39 | 9.62 | 243 | 123853 | 296289 | 90208062 |
| International normalised ratio increased | 38.25 | 9.62 | 147 | 123949 | 47169 | 90457182 |
| Acute respiratory failure | 37.75 | 9.62 | 137 | 123959 | 42781 | 90461570 |
| Injury | 37.57 | 9.62 | 141 | 123955 | 197208 | 90307143 |
| Disease progression | 37.46 | 9.62 | 353 | 123743 | 156262 | 90348089 |
| Colitis ulcerative | 37.13 | 9.62 | 18 | 124078 | 60248 | 90444103 |
| Breast cancer stage II | 37.05 | 9.62 | 3 | 124093 | 35331 | 90469020 |
| Body height decreased | 36.97 | 9.62 | 62 | 124034 | 11887 | 90492464 |
| Sepsis | 36.60 | 9.62 | 392 | 123704 | 179422 | 90324929 |
| Platelet count decreased | 35.95 | 9.62 | 315 | 123781 | 136654 | 90367697 |
| Chronic obstructive pulmonary disease | 35.56 | 9.62 | 197 | 123899 | 73632 | 90430719 |
| Hypervolaemia | 35.36 | 9.62 | 112 | 123984 | 32645 | 90471706 |
| Knee arthroplasty | 35.32 | 9.62 | 37 | 124059 | 83145 | 90421206 |
| Cholelithiasis | 35.23 | 9.62 | 154 | 123942 | 52352 | 90451999 |
| Peritonitis bacterial | 34.63 | 9.62 | 39 | 124057 | 5132 | 90499219 |
| Hepatic cirrhosis | 34.48 | 9.62 | 22 | 124074 | 63231 | 90441120 |
| Thrombocytopenia | 34.03 | 9.62 | 436 | 123660 | 208289 | 90296062 |
| Exposure via breast milk | 34.01 | 9.62 | 27 | 124069 | 2288 | 90502063 |
| Frequent bowel movements | 33.59 | 9.62 | 18 | 124078 | 56917 | 90447434 |
| Rash | 33.03 | 9.62 | 834 | 123262 | 795266 | 89709085 |
| Drug tolerance decreased | 32.95 | 9.62 | 3 | 124093 | 32127 | 90472224 |
| Hypothalamo-pituitary disorder | 32.52 | 9.62 | 26 | 124070 | 2226 | 90502125 |
| Prescribed underdose | 32.27 | 9.62 | 33 | 124063 | 74986 | 90429365 |
| Magnesium deficiency | 32.02 | 9.62 | 17 | 124079 | 720 | 90503631 |
| Pulmonary mass | 31.63 | 9.62 | 99 | 123997 | 28673 | 90475678 |
| Lower limb fracture | 31.61 | 9.62 | 42 | 124054 | 84971 | 90419380 |
| Unresponsive to stimuli | 31.28 | 9.62 | 119 | 123977 | 38002 | 90466349 |
| Sputum discoloured | 31.10 | 9.62 | 79 | 124017 | 20312 | 90484039 |
| Gastrointestinal haemorrhage | 31.08 | 9.62 | 221 | 123875 | 90027 | 90414324 |
| Prescribed overdose | 30.73 | 9.62 | 234 | 123862 | 97391 | 90406960 |
| Liver disorder | 30.69 | 9.62 | 76 | 124020 | 121193 | 90383158 |
| Pregnancy | 30.64 | 9.62 | 24 | 124072 | 62023 | 90442328 |
| Lactation disorder | 30.22 | 9.62 | 14 | 124082 | 440 | 90503911 |
| Epistaxis | 30.22 | 9.62 | 210 | 123886 | 84915 | 90419436 |
| Myoclonus | 30.00 | 9.62 | 75 | 124021 | 19093 | 90485258 |
| Toxicity to various agents | 29.96 | 9.62 | 251 | 123845 | 287595 | 90216756 |
| Heart rate increased | 29.81 | 9.62 | 260 | 123836 | 112642 | 90391709 |
| Exostosis | 29.63 | 9.62 | 18 | 124078 | 53116 | 90451235 |
| Hypophagia | 29.34 | 9.62 | 112 | 123984 | 35825 | 90468526 |
| Hysterectomy | 29.26 | 9.62 | 55 | 124041 | 11529 | 90492822 |
| Abortion spontaneous | 29.19 | 9.62 | 19 | 124077 | 54037 | 90450314 |
| Blood creatinine increased | 29.16 | 9.62 | 238 | 123858 | 101148 | 90403203 |
| Drug ineffective for unapproved indication | 29.03 | 9.62 | 29 | 124067 | 66615 | 90437736 |
| Chest pain | 28.98 | 9.62 | 606 | 123490 | 319039 | 90185312 |
| Sleep apnoea syndrome | 28.48 | 9.62 | 102 | 123994 | 31645 | 90472706 |
| Drug-induced liver injury | 28.41 | 9.62 | 50 | 124046 | 90268 | 90414083 |
| Thrombosis | 27.97 | 9.62 | 184 | 123912 | 73067 | 90431284 |
| Respiratory failure | 27.86 | 9.62 | 266 | 123830 | 118152 | 90386199 |
| Carbohydrate antigen 125 increased | 27.84 | 9.62 | 28 | 124068 | 3238 | 90501113 |
| Premenstrual syndrome | 27.81 | 9.62 | 16 | 124080 | 794 | 90503557 |
| Dysphagia | 27.81 | 9.62 | 255 | 123841 | 112023 | 90392328 |
| Drug hypersensitivity | 27.75 | 9.62 | 457 | 123639 | 463152 | 90041199 |
| Blood test abnormal | 27.72 | 9.62 | 77 | 124019 | 20875 | 90483476 |
| Neuropathy peripheral | 27.59 | 9.62 | 298 | 123798 | 136672 | 90367679 |
| Poor sucking reflex | 27.39 | 9.62 | 13 | 124083 | 432 | 90503919 |
| Fibrosis | 27.13 | 9.62 | 37 | 124059 | 5915 | 90498436 |
| Rheumatoid arthritis | 27.12 | 9.62 | 342 | 123754 | 362272 | 90142079 |
| Retching | 26.93 | 9.62 | 72 | 124024 | 19087 | 90485264 |
| Neutrophil count decreased | 26.90 | 9.62 | 179 | 123917 | 71353 | 90432998 |
| Excessive eye blinking | 26.84 | 9.62 | 19 | 124077 | 1353 | 90502998 |
| Urinary incontinence | 26.60 | 9.62 | 112 | 123984 | 37454 | 90466897 |
| Onychomycosis | 26.54 | 9.62 | 9 | 124087 | 37367 | 90466984 |
| Decubitus ulcer | 26.08 | 9.62 | 53 | 124043 | 11760 | 90492591 |
| Haematocrit decreased | 26.04 | 9.62 | 120 | 123976 | 41712 | 90462639 |
| Autonomic dysreflexia | 26 | 9.62 | 12 | 124084 | 374 | 90503977 |
| Iron deficiency anaemia | 25.63 | 9.62 | 81 | 124015 | 23581 | 90480770 |
| Medication error | 25.61 | 9.62 | 48 | 124048 | 84604 | 90419747 |
| Suicide attempt | 25.33 | 9.62 | 40 | 124056 | 75359 | 90428992 |
| Hepatitis | 25.25 | 9.62 | 36 | 124060 | 70703 | 90433648 |
| Pneumonia viral | 24.96 | 9.62 | 44 | 124052 | 8779 | 90495572 |
| Product quality issue | 24.88 | 9.62 | 44 | 124052 | 79281 | 90425070 |
| Dental restoration failure | 24.84 | 9.62 | 17 | 124079 | 1147 | 90503204 |
| Sinusitis | 24.76 | 9.62 | 326 | 123770 | 342762 | 90161589 |
| Polymenorrhoea | 24.04 | 9.62 | 18 | 124078 | 1399 | 90502952 |
| Hyperaesthesia | 23.61 | 9.62 | 48 | 124048 | 10654 | 90493697 |
| Granulocytopenia | 23.46 | 9.62 | 36 | 124060 | 6405 | 90497946 |
| Haemorrhoids | 23.28 | 9.62 | 85 | 124011 | 26617 | 90477734 |
| Flatulence | 23.10 | 9.62 | 115 | 123981 | 41252 | 90463099 |
| Back injury | 23.06 | 9.62 | 18 | 124078 | 46604 | 90457747 |
| Sciatica | 23.03 | 9.62 | 67 | 124029 | 101315 | 90403036 |
| Overweight | 22.80 | 9.62 | 34 | 124062 | 5900 | 90498451 |
| Emotional distress | 22.70 | 9.62 | 105 | 123991 | 36557 | 90467794 |
| Wrist deformity | 22.68 | 9.62 | 25 | 124071 | 3213 | 90501138 |
| Presyncope | 22.66 | 9.62 | 95 | 124001 | 31710 | 90472641 |
| Pre-eclampsia | 22.56 | 9.62 | 48 | 124048 | 11000 | 90493351 |
| Ear infection | 22.52 | 9.62 | 38 | 124058 | 69737 | 90434614 |
| Lip pruritus | 22.46 | 9.62 | 17 | 124079 | 1343 | 90503008 |
| Joint dislocation | 22.32 | 9.62 | 17 | 124079 | 44565 | 90459786 |
| Transient ischaemic attack | 22.00 | 9.62 | 117 | 123979 | 43059 | 90461292 |
| Dyslipidaemia | 21.91 | 9.62 | 45 | 124051 | 10062 | 90494289 |
| Transfusion | 21.89 | 9.62 | 63 | 124033 | 17425 | 90486926 |
| Musculoskeletal pain | 21.81 | 9.62 | 141 | 123955 | 171110 | 90333241 |
| Interstitial lung disease | 21.67 | 9.62 | 45 | 124051 | 76360 | 90427991 |
| Maternal exposure during breast feeding | 21.59 | 9.62 | 34 | 124062 | 6186 | 90498165 |
| Blood glucose increased | 21.44 | 9.62 | 212 | 123884 | 95034 | 90409317 |
| Cerebrovascular accident | 21.39 | 9.62 | 261 | 123835 | 123272 | 90381079 |
| Menstruation delayed | 21.30 | 9.62 | 20 | 124076 | 2125 | 90502226 |
| Onychoclasis | 21.06 | 9.62 | 37 | 124059 | 7362 | 90496989 |
| Haemoptysis | 21.05 | 9.62 | 96 | 124000 | 33224 | 90471127 |
| Dyspnoea exertional | 20.95 | 9.62 | 170 | 123926 | 72118 | 90432233 |
| Oedema | 20.67 | 9.62 | 175 | 123921 | 200120 | 90304231 |
| Supraventricular tachycardia | 20.60 | 9.62 | 59 | 124037 | 16277 | 90488074 |
| Multiple sclerosis | 20.49 | 9.62 | 84 | 124012 | 27756 | 90476595 |
| Contusion | 20.27 | 9.62 | 233 | 123863 | 250983 | 90253368 |
| Lichen sclerosus | 20.25 | 9.62 | 16 | 124080 | 1347 | 90503004 |
| Acute kidney injury | 20.17 | 9.62 | 578 | 123518 | 319809 | 90184542 |
| Hepatic enzyme increased | 20.14 | 9.62 | 360 | 123736 | 360376 | 90143975 |
| Asthma | 19.98 | 9.62 | 453 | 123643 | 241707 | 90262644 |
| Red blood cell count decreased | 19.92 | 9.62 | 120 | 123976 | 46231 | 90458120 |
| Carotid artery occlusion | 19.74 | 9.62 | 33 | 124063 | 6309 | 90498042 |
| Premature baby | 19.71 | 9.62 | 5 | 124091 | 25072 | 90479279 |
| Nasal polyps | 19.65 | 9.62 | 45 | 124051 | 10835 | 90493516 |
| Infusion related reaction | 19.63 | 9.62 | 428 | 123668 | 416352 | 90087999 |
| Peripheral swelling | 19.52 | 9.62 | 424 | 123672 | 412682 | 90091669 |
| Drug interaction | 19.46 | 9.62 | 264 | 123832 | 276189 | 90228162 |
| Palmoplantar keratoderma | 19.42 | 9.62 | 24 | 124072 | 3483 | 90500868 |
| Bronchiectasis | 19.40 | 9.62 | 71 | 124025 | 22259 | 90482092 |
| Pneumococcal infection | 19.33 | 9.62 | 15 | 124081 | 1230 | 90503121 |
| Drug reaction with eosinophilia and systemic symptoms | 19.32 | 9.62 | 18 | 124078 | 42740 | 90461611 |
| Uterine perforation | 19.24 | 9.62 | 36 | 124060 | 7518 | 90496833 |
| Oesophageal ulcer | 19.19 | 9.62 | 29 | 124067 | 5090 | 90499261 |
| Blood calcium decreased | 19.10 | 9.62 | 87 | 124009 | 30095 | 90474256 |
| Decreased immune responsiveness | 19.02 | 9.62 | 39 | 124057 | 8709 | 90495642 |
| Abdominal distension | 18.88 | 9.62 | 267 | 123829 | 130334 | 90374017 |
| Drooling | 18.84 | 9.62 | 27 | 124069 | 4519 | 90499832 |
| Dyspepsia | 18.76 | 9.62 | 177 | 123919 | 197983 | 90306368 |
| Thyroid atrophy | 18.75 | 9.62 | 9 | 124087 | 307 | 90504044 |
| Device expulsion | 18.73 | 9.62 | 17 | 124079 | 40869 | 90463482 |
| Maternal exposure timing unspecified | 18.63 | 9.62 | 4 | 124092 | 22479 | 90481872 |
| Lower gastrointestinal haemorrhage | 18.58 | 9.62 | 39 | 124057 | 8853 | 90495498 |
| Taste disorder | 18.53 | 9.62 | 35 | 124061 | 61511 | 90442840 |
| Hallucination | 18.51 | 9.62 | 154 | 123942 | 65805 | 90438546 |
| Intestinal obstruction | 18.50 | 9.62 | 100 | 123996 | 37031 | 90467320 |
| Body temperature fluctuation | 18.47 | 9.62 | 19 | 124077 | 2256 | 90502095 |
| Chronic sinusitis | 18.47 | 9.62 | 73 | 124023 | 23729 | 90480622 |
| Vomiting | 18.44 | 9.62 | 1284 | 122812 | 787009 | 89717342 |
| Hyperlipidaemia | 18.36 | 9.62 | 71 | 124025 | 22845 | 90481506 |
| Proctalgia | 18.36 | 9.62 | 37 | 124059 | 8161 | 90496190 |
| Atelectasis | 18.25 | 9.62 | 74 | 124022 | 24335 | 90480016 |
| Cardiospasm | 18.15 | 9.62 | 23 | 124073 | 3423 | 90500928 |
| Oesophageal irritation | 18.10 | 9.62 | 9 | 124087 | 332 | 90504019 |
| Rheumatoid nodule | 17.96 | 9.62 | 3 | 124093 | 20163 | 90484188 |
| Cognitive disorder | 17.88 | 9.62 | 159 | 123937 | 69248 | 90435103 |
| Nasopharyngitis | 17.77 | 9.62 | 423 | 123673 | 406681 | 90097670 |
| Musculoskeletal chest pain | 17.75 | 9.62 | 72 | 124024 | 23678 | 90480673 |
| Hypoaesthesia | 17.72 | 9.62 | 313 | 123783 | 313897 | 90190454 |
| Cardiac murmur | 17.66 | 9.62 | 60 | 124036 | 18134 | 90486217 |
| Epiglottic erythema | 17.64 | 9.62 | 6 | 124090 | 81 | 90504270 |
| Noninfectious peritonitis | 17.60 | 9.62 | 7 | 124089 | 150 | 90504201 |
| Pulmonary hypertension | 17.58 | 9.62 | 109 | 123987 | 42414 | 90461937 |
| Nephropathy | 17.57 | 9.62 | 39 | 124057 | 9196 | 90495155 |
| Dysmetropsia | 17.44 | 9.62 | 6 | 124090 | 84 | 90504267 |
| Cough | 17.36 | 9.62 | 643 | 123453 | 368319 | 90136032 |
| Blood loss anaemia | 17.28 | 9.62 | 41 | 124055 | 10099 | 90494252 |
| Cholecystitis chronic | 17.04 | 9.62 | 40 | 124056 | 9786 | 90494565 |
| Epiglottic oedema | 16.86 | 9.62 | 7 | 124089 | 168 | 90504183 |
| Migraine | 16.79 | 9.62 | 173 | 123923 | 190219 | 90314132 |
| Accidental exposure to product | 16.72 | 9.62 | 20 | 124076 | 42346 | 90462005 |
| Lower respiratory tract infection | 16.70 | 9.62 | 242 | 123854 | 250417 | 90253934 |
| Renal failure | 16.66 | 9.62 | 262 | 123834 | 130745 | 90373606 |
| Adverse reaction | 16.66 | 9.62 | 10 | 124086 | 29702 | 90474649 |
| Nasal discharge discolouration | 16.57 | 9.62 | 20 | 124076 | 2833 | 90501518 |
| Candida infection | 16.48 | 9.62 | 91 | 124005 | 33966 | 90470385 |
| Loss of personal independence in daily activities | 16.36 | 9.62 | 114 | 123982 | 135991 | 90368360 |
| Sleep terror | 16.33 | 9.62 | 25 | 124071 | 4439 | 90499912 |
| Pruritus | 16.29 | 9.62 | 592 | 123504 | 540933 | 89963418 |
| Pruritus genital | 15.94 | 9.62 | 25 | 124071 | 4533 | 90499818 |
| Injection site erythema | 15.88 | 9.62 | 75 | 124021 | 98427 | 90405924 |
| Blood bilirubin decreased | 15.80 | 9.62 | 12 | 124084 | 953 | 90503398 |
| Diarrhoea | 15.70 | 9.62 | 1491 | 122605 | 937699 | 89566652 |
| Urinary tract infection enterococcal | 15.68 | 9.62 | 20 | 124076 | 2996 | 90501355 |
| Productive cough | 15.67 | 9.62 | 168 | 123928 | 76895 | 90427456 |
| Urinary retention postoperative | 15.61 | 9.62 | 6 | 124090 | 117 | 90504234 |
| Renal cyst | 15.59 | 9.62 | 46 | 124050 | 12904 | 90491447 |
| Duodenal stenosis | 15.37 | 9.62 | 10 | 124086 | 620 | 90503731 |
| Weight increased | 15.15 | 9.62 | 446 | 123650 | 417481 | 90086870 |
| Restless legs syndrome | 15.14 | 9.62 | 66 | 124030 | 22404 | 90481947 |
| Dry mouth | 15.12 | 9.62 | 170 | 123926 | 183889 | 90320462 |
| Seizure | 15.02 | 9.62 | 293 | 123803 | 152336 | 90352015 |
| Nasal congestion | 14.77 | 9.62 | 177 | 123919 | 83237 | 90421114 |
| Ear pain | 14.72 | 9.62 | 36 | 124060 | 57666 | 90446685 |
| Anaphylactic shock | 14.66 | 9.62 | 13 | 124083 | 31604 | 90472747 |
| Electrocardiogram PR prolongation | 14.64 | 9.62 | 11 | 124085 | 859 | 90503492 |
| Chills | 14.60 | 9.62 | 258 | 123838 | 131723 | 90372628 |
| Lymphocyte count decreased | 14.59 | 9.62 | 90 | 124006 | 34960 | 90469391 |
| Pneumonitis | 14.53 | 9.62 | 107 | 123989 | 44063 | 90460288 |
| Neuralgia | 14.47 | 9.62 | 83 | 124013 | 31417 | 90472934 |
| Pulmonary fibrosis | 14.46 | 9.62 | 87 | 124009 | 107416 | 90396935 |
| Mean platelet volume increased | 14.34 | 9.62 | 11 | 124085 | 886 | 90503465 |
| Breath sounds abnormal | 14.29 | 9.62 | 50 | 124046 | 15336 | 90489015 |
| Ascites | 14.23 | 9.62 | 113 | 123983 | 47627 | 90456724 |
| Wheezing | 14.12 | 9.62 | 235 | 123861 | 237845 | 90266506 |
| Mitochondrial myopathy | 14.11 | 9.62 | 7 | 124089 | 257 | 90504094 |
| Pustular psoriasis | 14.02 | 9.62 | 4 | 124092 | 18552 | 90485799 |
| Chronic kidney disease | 13.99 | 9.62 | 117 | 123979 | 50074 | 90454277 |
| Proteinuria | 13.90 | 9.62 | 66 | 124030 | 23225 | 90481126 |
| Cardiomegaly | 13.85 | 9.62 | 57 | 124039 | 18868 | 90485483 |
| Spinal compression fracture | 13.81 | 9.62 | 49 | 124047 | 15129 | 90489222 |
| Gastrointestinal arteriovenous malformation | 13.72 | 9.62 | 9 | 124087 | 566 | 90503785 |
| Bladder disorder | 13.67 | 9.62 | 39 | 124057 | 10733 | 90493618 |
| Catheter site bruise | 13.59 | 9.62 | 9 | 124087 | 575 | 90503776 |
| Blood sodium decreased | 13.51 | 9.62 | 74 | 124022 | 27539 | 90476812 |
| Rubber sensitivity | 13.49 | 9.62 | 18 | 124078 | 2819 | 90501532 |
| Injection site pruritus | 13.41 | 9.62 | 34 | 124062 | 53800 | 90450551 |
| Clostridium difficile infection | 13.21 | 9.62 | 90 | 124006 | 36155 | 90468196 |
| Ecchymosis | 13.18 | 9.62 | 42 | 124054 | 12281 | 90492070 |
| Sinus bradycardia | 13.16 | 9.62 | 52 | 124044 | 16900 | 90487451 |
| Foetal exposure timing unspecified | 13.14 | 9.62 | 8 | 124088 | 441 | 90503910 |
| Drug abuse | 13.09 | 9.62 | 63 | 124033 | 82284 | 90422067 |
| Escherichia bacteraemia | 12.98 | 9.62 | 26 | 124070 | 5709 | 90498642 |
| Intentional underdose | 12.95 | 9.62 | 15 | 124081 | 2034 | 90502317 |
| Adverse drug reaction | 12.94 | 9.62 | 100 | 123996 | 116601 | 90387750 |
| Upper gastrointestinal haemorrhage | 12.91 | 9.62 | 64 | 124032 | 22912 | 90481439 |
| Hypersomnia | 12.84 | 9.62 | 61 | 124035 | 21470 | 90482881 |
| Dysstasia | 12.84 | 9.62 | 68 | 124028 | 24984 | 90479367 |
| Injection site warmth | 12.82 | 9.62 | 4 | 124092 | 17511 | 90486840 |
| Localised oedema | 12.75 | 9.62 | 27 | 124069 | 6167 | 90498184 |
| Abdominal hernia | 12.69 | 9.62 | 26 | 124070 | 5802 | 90498549 |
| Arteriovenous graft site infection | 12.64 | 9.62 | 3 | 124093 | 9 | 90504342 |
| Premature delivery | 12.61 | 9.62 | 21 | 124075 | 38741 | 90465610 |
| Non-small cell lung cancer | 12.59 | 9.62 | 22 | 124074 | 4359 | 90499992 |
| Calculus bladder | 12.58 | 9.62 | 9 | 124087 | 652 | 90503699 |
| Multiple sclerosis relapse | 12.55 | 9.62 | 118 | 123978 | 52187 | 90452164 |
| Lip swelling | 12.40 | 9.62 | 93 | 124003 | 38517 | 90465834 |
| Malignant neoplasm of thorax | 12.40 | 9.62 | 3 | 124093 | 10 | 90504341 |
| Catheter site pain | 12.28 | 9.62 | 25 | 124071 | 5554 | 90498797 |
| Spleen atrophy | 12.26 | 9.62 | 4 | 124092 | 47 | 90504304 |
| Hot flush | 12.24 | 9.62 | 130 | 123966 | 59358 | 90444993 |
| Atrial tachycardia | 12.20 | 9.62 | 26 | 124070 | 5964 | 90498387 |
| Troponin increased | 12.19 | 9.62 | 43 | 124053 | 13238 | 90491113 |
| Immunisation | 12.02 | 9.62 | 15 | 124081 | 2198 | 90502153 |
| Gastrointestinal tract mucosal pigmentation | 12.01 | 9.62 | 9 | 124087 | 700 | 90503651 |
| Use of accessory respiratory muscles | 12.01 | 9.62 | 7 | 124089 | 356 | 90503995 |
| Orthostatic hypotension | 11.92 | 9.62 | 98 | 123998 | 41729 | 90462622 |
| Hypophosphataemia | 11.88 | 9.62 | 46 | 124050 | 14808 | 90489543 |
| End stage renal disease | 11.84 | 9.62 | 32 | 124064 | 8539 | 90495812 |
| Asterixis | 11.78 | 9.62 | 13 | 124083 | 1672 | 90502679 |
| Haemorrhage | 11.76 | 9.62 | 146 | 123950 | 69223 | 90435128 |
| Cytokine release syndrome | 11.75 | 9.62 | 72 | 124024 | 27901 | 90476450 |
| Burkholderia test positive | 11.66 | 9.62 | 6 | 124090 | 238 | 90504113 |
| Myocardial infarction | 11.66 | 9.62 | 207 | 123889 | 105765 | 90398586 |
| Multiple drug therapy | 11.58 | 9.62 | 28 | 124068 | 6981 | 90497370 |
| Impaired work ability | 11.56 | 9.62 | 6 | 124090 | 19320 | 90485031 |
| Enterocele | 11.56 | 9.62 | 4 | 124092 | 57 | 90504294 |
| Pulmonary oedema | 11.55 | 9.62 | 133 | 123963 | 61947 | 90442404 |
| Blood phosphorus increased | 11.53 | 9.62 | 21 | 124075 | 4297 | 90500054 |
| Heart rate decreased | 11.51 | 9.62 | 118 | 123978 | 53387 | 90450964 |
| Paraesthesia | 11.50 | 9.62 | 258 | 123838 | 250068 | 90254283 |
| Pericardial effusion | 11.43 | 9.62 | 88 | 124008 | 36745 | 90467606 |
| Intentional self-injury | 11.41 | 9.62 | 14 | 124082 | 29320 | 90475031 |
| Drug resistance | 11.36 | 9.62 | 15 | 124081 | 30434 | 90473917 |
| Gingival pain | 11.35 | 9.62 | 34 | 124062 | 9618 | 90494733 |
| Stoma site erythema | 11.26 | 9.62 | 12 | 124084 | 1484 | 90502867 |
| Infusion site reaction | 11.26 | 9.62 | 6 | 124090 | 19033 | 90485318 |
| Product use issue | 11.23 | 9.62 | 355 | 123741 | 329564 | 90174787 |
| Vasculitis | 11.22 | 9.62 | 61 | 124035 | 22632 | 90481719 |
| Aortic stenosis | 11.21 | 9.62 | 26 | 124070 | 6310 | 90498041 |
| Diabetes mellitus | 11.19 | 9.62 | 137 | 123959 | 64738 | 90439613 |
| Laryngitis | 11.19 | 9.62 | 34 | 124062 | 50719 | 90453632 |
| Anaphylactic reaction | 11.17 | 9.62 | 72 | 124024 | 87452 | 90416899 |
| Cardiomyopathy | 11.16 | 9.62 | 56 | 124040 | 20150 | 90484201 |
| Peritonitis | 11.15 | 9.62 | 55 | 124041 | 19650 | 90484701 |
| Mean cell haemoglobin concentration decreased | 11.15 | 9.62 | 21 | 124075 | 4407 | 90499944 |
| Embolic stroke | 11.12 | 9.62 | 20 | 124076 | 4052 | 90500299 |
| Posture abnormal | 11.09 | 9.62 | 16 | 124080 | 2695 | 90501656 |
| Macular degeneration | 11.07 | 9.62 | 22 | 124074 | 37948 | 90466403 |
| Dysuria | 11.06 | 9.62 | 92 | 124004 | 39309 | 90465042 |
| Lactic acidosis | 10.99 | 9.62 | 34 | 124062 | 50429 | 90453922 |
| Wrong product administered | 10.97 | 9.62 | 29 | 124067 | 7636 | 90496715 |
| Conjunctival pigmentation | 10.97 | 9.62 | 4 | 124092 | 67 | 90504284 |
| Brain neoplasm | 10.95 | 9.62 | 22 | 124074 | 4842 | 90499509 |
| Vision blurred | 10.94 | 9.62 | 212 | 123884 | 110081 | 90394270 |
| Blindness | 10.92 | 9.62 | 68 | 124028 | 26500 | 90477851 |
| Hypersensitivity | 10.91 | 9.62 | 510 | 123586 | 454167 | 90050184 |
| Moaning | 10.89 | 9.62 | 10 | 124086 | 1033 | 90503318 |
| Ventricular tachycardia | 10.63 | 9.62 | 64 | 124032 | 24644 | 90479707 |
| Injection site swelling | 10.59 | 9.62 | 44 | 124052 | 59795 | 90444556 |
| Sleep disorder due to a general medical condition | 10.58 | 9.62 | 29 | 124067 | 44709 | 90459642 |
| Abdominal mass | 10.53 | 9.62 | 18 | 124078 | 3503 | 90500848 |
| Transaminases increased | 10.52 | 9.62 | 87 | 124009 | 37105 | 90467246 |
| Anhedonia | 10.49 | 9.62 | 37 | 124059 | 11394 | 90492957 |
| Erythema | 10.40 | 9.62 | 398 | 123698 | 228848 | 90275503 |
| Blood pressure decreased | 10.38 | 9.62 | 152 | 123944 | 74743 | 90429608 |
| Hypovolaemia | 10.36 | 9.62 | 39 | 124057 | 12392 | 90491959 |
| Post procedural haemorrhage | 10.35 | 9.62 | 31 | 124065 | 8767 | 90495584 |
| Open angle glaucoma | 10.32 | 9.62 | 6 | 124090 | 304 | 90504047 |
| Hyperglycaemia | 10.30 | 9.62 | 111 | 123985 | 50859 | 90453492 |
| Urinary tract obstruction | 10.28 | 9.62 | 14 | 124082 | 2235 | 90502116 |
| Faeces hard | 10.27 | 9.62 | 17 | 124079 | 3225 | 90501126 |
| Postpartum anxiety | 10.23 | 9.62 | 3 | 124093 | 24 | 90504327 |
| Blood urea nitrogen/creatinine ratio increased | 10.14 | 9.62 | 10 | 124086 | 1129 | 90503222 |
| Implant site erosion | 10.04 | 9.62 | 4 | 124092 | 86 | 90504265 |
| Injection site rash | 9.98 | 9.62 | 11 | 124085 | 24162 | 90480189 |
| Weight decreased | 9.96 | 9.62 | 625 | 123471 | 379285 | 90125066 |
| Hepatotoxicity | 9.90 | 9.62 | 31 | 124065 | 45811 | 90458540 |
| Therapeutic response decreased | 9.89 | 9.62 | 77 | 124019 | 89652 | 90414699 |
| Facial pain | 9.88 | 9.62 | 40 | 124056 | 13142 | 90491209 |
| Cholestasis | 9.78 | 9.62 | 22 | 124074 | 36277 | 90468074 |
| Blood potassium increased | 9.74 | 9.62 | 55 | 124041 | 20694 | 90483657 |
| Right ventricular dysfunction | 9.74 | 9.62 | 14 | 124082 | 2350 | 90502001 |
| Paraphilia | 9.72 | 9.62 | 3 | 124093 | 29 | 90504322 |
| Faeces discoloured | 9.68 | 9.62 | 56 | 124040 | 21264 | 90483087 |
| Purpura | 9.65 | 9.62 | 43 | 124053 | 14735 | 90489616 |
| Large intestinal obstruction | 9.65 | 9.62 | 15 | 124081 | 2699 | 90501652 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug ineffective | 278.44 | 10.51 | 486 | 80733 | 629711 | 41910405 |
| Constipation | 211.66 | 10.51 | 735 | 80484 | 161556 | 42378560 |
| Drug abuse | 127.14 | 10.51 | 23 | 81196 | 104748 | 42435368 |
| Off label use | 126.84 | 10.51 | 708 | 80511 | 637627 | 41902489 |
| Neuritis | 112.54 | 10.51 | 94 | 81125 | 6126 | 42533990 |
| Pulmonary vasculitis | 109.88 | 10.51 | 93 | 81126 | 6173 | 42533943 |
| Respiratory symptom | 102.57 | 10.51 | 116 | 81103 | 10990 | 42529126 |
| Completed suicide | 97.79 | 10.51 | 31 | 81188 | 96434 | 42443682 |
| Febrile neutropenia | 93.00 | 10.51 | 639 | 80580 | 185064 | 42355052 |
| Plasma cell myeloma | 92.37 | 10.51 | 248 | 80971 | 47330 | 42492786 |
| Neurological symptom | 81.65 | 10.51 | 98 | 81121 | 9893 | 42530223 |
| Total lung capacity abnormal | 78.02 | 10.51 | 66 | 81153 | 4377 | 42535739 |
| Mental status changes | 77.24 | 10.51 | 215 | 81004 | 41900 | 42498216 |
| Urinary tract infection | 75.83 | 10.51 | 382 | 80837 | 98902 | 42441214 |
| Thrombosis | 68.99 | 10.51 | 286 | 80933 | 68225 | 42471891 |
| Eosinophilic granulomatosis with polyangiitis | 67.77 | 10.51 | 83 | 81136 | 8555 | 42531561 |
| Conjunctivitis allergic | 65.54 | 10.51 | 68 | 81151 | 5843 | 42534273 |
| Death | 65.28 | 10.51 | 1259 | 79960 | 469926 | 42070190 |
| Toxicity to various agents | 63.41 | 10.51 | 224 | 80995 | 228912 | 42311204 |
| IVth nerve paralysis | 59.91 | 10.51 | 27 | 81192 | 564 | 42539552 |
| Full blood count abnormal | 59.25 | 10.51 | 157 | 81062 | 29719 | 42510397 |
| Intentional overdose | 56.85 | 10.51 | 14 | 81205 | 51442 | 42488674 |
| Mite allergy | 55.86 | 10.51 | 58 | 81161 | 4988 | 42535128 |
| Hypoxia | 55.74 | 10.51 | 272 | 80947 | 69514 | 42470602 |
| Mycotic allergy | 55.55 | 10.51 | 57 | 81162 | 4834 | 42535282 |
| Dust allergy | 54.96 | 10.51 | 59 | 81160 | 5273 | 42534843 |
| Spirometry abnormal | 54.91 | 10.51 | 58 | 81161 | 5088 | 42535028 |
| Pneumonia | 52.73 | 10.51 | 1111 | 80108 | 421038 | 42119078 |
| Treatment failure | 52.26 | 10.51 | 27 | 81192 | 62597 | 42477519 |
| Pulmonary alveolar haemorrhage | 52.22 | 10.51 | 98 | 81121 | 14718 | 42525398 |
| Forced expiratory volume decreased | 51.46 | 10.51 | 68 | 81151 | 7562 | 42532554 |
| Antineutrophil cytoplasmic antibody positive | 48.01 | 10.51 | 50 | 81169 | 4315 | 42535801 |
| Anal inflammation | 47.34 | 10.51 | 37 | 81182 | 2192 | 42537924 |
| Fall | 46.50 | 10.51 | 665 | 80554 | 233855 | 42306261 |
| SARS-CoV-2 test negative | 45.56 | 10.51 | 33 | 81186 | 1742 | 42538374 |
| Drug resistance | 44.96 | 10.51 | 6 | 81213 | 34242 | 42505874 |
| Accident | 42.39 | 10.51 | 57 | 81162 | 6446 | 42533670 |
| Failure to thrive | 41.86 | 10.51 | 69 | 81150 | 9353 | 42530763 |
| Proctalgia | 41.47 | 10.51 | 59 | 81160 | 7034 | 42533082 |
| Myelosuppression | 40.99 | 10.51 | 13 | 81206 | 40448 | 42499668 |
| Myasthenia gravis | 40.70 | 10.51 | 93 | 81126 | 16044 | 42524072 |
| Drug interaction | 40.16 | 10.51 | 321 | 80898 | 266678 | 42273438 |
| Capillaritis | 38.92 | 10.51 | 33 | 81186 | 2195 | 42537921 |
| Pulmonary embolism | 38.78 | 10.51 | 373 | 80846 | 119239 | 42420877 |
| Haemoptysis | 38.33 | 10.51 | 182 | 81037 | 45985 | 42494131 |
| Fatigue | 38.24 | 10.51 | 1093 | 80126 | 434548 | 42105568 |
| Vasculitis | 37.83 | 10.51 | 98 | 81121 | 18296 | 42521820 |
| Burkholderia test positive | 37.63 | 10.51 | 24 | 81195 | 1026 | 42539090 |
| Failure to suspend medication | 36.46 | 10.51 | 17 | 81202 | 385 | 42539731 |
| Normochromic normocytic anaemia | 35.98 | 10.51 | 63 | 81156 | 8968 | 42531148 |
| Drug therapy | 35.74 | 10.51 | 52 | 81167 | 6328 | 42533788 |
| Interstitial lung disease | 35.71 | 10.51 | 59 | 81160 | 78403 | 42461713 |
| Dehydration | 35.63 | 10.51 | 420 | 80799 | 141347 | 42398769 |
| Hyperphosphataemia | 35.10 | 10.51 | 77 | 81142 | 12927 | 42527189 |
| Analgesic therapy | 34.85 | 10.51 | 52 | 81167 | 6472 | 42533644 |
| Sepsis | 34.73 | 10.51 | 553 | 80666 | 198781 | 42341335 |
| C-reactive protein increased | 34.68 | 10.51 | 42 | 81177 | 63518 | 42476598 |
| Blood test abnormal | 34.36 | 10.51 | 76 | 81143 | 12830 | 42527286 |
| Cholestasis | 34.32 | 10.51 | 10 | 81209 | 32869 | 42507247 |
| Coma | 34.15 | 10.51 | 31 | 81188 | 53523 | 42486593 |
| Hepatic function abnormal | 33.90 | 10.51 | 29 | 81190 | 51538 | 42488578 |
| Drug reaction with eosinophilia and systemic symptoms | 33.85 | 10.51 | 19 | 81200 | 42056 | 42498060 |
| IgA nephropathy | 33.19 | 10.51 | 31 | 81188 | 2343 | 42537773 |
| Confusional state | 33.08 | 10.51 | 475 | 80744 | 167122 | 42372994 |
| Vomiting | 33.04 | 10.51 | 753 | 80466 | 288970 | 42251146 |
| Obstructive airways disorder | 32.90 | 10.51 | 113 | 81106 | 24646 | 42515470 |
| Foetal exposure during pregnancy | 31.85 | 10.51 | 26 | 81193 | 47285 | 42492831 |
| Drug ineffective for unapproved indication | 31.54 | 10.51 | 25 | 81194 | 46138 | 42493978 |
| Nodule | 31.35 | 10.51 | 72 | 81147 | 12462 | 42527654 |
| Hypersomnia | 31.22 | 10.51 | 79 | 81140 | 14539 | 42525577 |
| Product use in unapproved indication | 30.93 | 10.51 | 215 | 81004 | 184241 | 42355875 |
| Hospice care | 30.86 | 10.51 | 57 | 81162 | 8456 | 42531660 |
| Hyponatraemia | 30.25 | 10.51 | 311 | 80908 | 101151 | 42438965 |
| Pulmonary fibrosis | 29.73 | 10.51 | 115 | 81104 | 26566 | 42513550 |
| Renal impairment | 29.61 | 10.51 | 109 | 81110 | 110119 | 42429997 |
| Appendicolith | 29.03 | 10.51 | 73 | 81146 | 13383 | 42526733 |
| Neuralgia | 28.95 | 10.51 | 111 | 81108 | 25536 | 42514580 |
| Back pain | 28.84 | 10.51 | 404 | 80815 | 141372 | 42398744 |
| Hallucination | 28.76 | 10.51 | 198 | 81021 | 57309 | 42482807 |
| Asthenia | 28.72 | 10.51 | 719 | 80500 | 280074 | 42260042 |
| Anticoagulant therapy | 28.42 | 10.51 | 39 | 81180 | 4496 | 42535620 |
| Haemorrhoids | 28.15 | 10.51 | 84 | 81135 | 17013 | 42523103 |
| Overdose | 27.68 | 10.51 | 105 | 81114 | 105159 | 42434957 |
| Painful respiration | 27.52 | 10.51 | 22 | 81197 | 1347 | 42538769 |
| Blood calcium increased | 27.43 | 10.51 | 54 | 81165 | 8400 | 42531716 |
| Sleep disorder therapy | 27.34 | 10.51 | 48 | 81171 | 6846 | 42533270 |
| Antacid therapy | 27.23 | 10.51 | 39 | 81180 | 4678 | 42535438 |
| Sleep disorder due to a general medical condition | 27.10 | 10.51 | 84 | 81135 | 17369 | 42522747 |
| Hepatocellular injury | 27.03 | 10.51 | 6 | 81213 | 23672 | 42516444 |
| Full blood count decreased | 26.59 | 10.51 | 93 | 81126 | 20467 | 42519649 |
| Hypophosphataemia | 26.45 | 10.51 | 94 | 81125 | 20851 | 42519265 |
| Abdominal distension | 26.42 | 10.51 | 230 | 80989 | 71505 | 42468611 |
| Hypothyroidism | 26.28 | 10.51 | 126 | 81093 | 31958 | 42508158 |
| Small intestinal obstruction | 25.47 | 10.51 | 81 | 81138 | 16980 | 42523136 |
| Walking aid user | 25.16 | 10.51 | 28 | 81191 | 2605 | 42537511 |
| Suicide attempt | 24.58 | 10.51 | 31 | 81188 | 46069 | 42494047 |
| Swelling | 24.57 | 10.51 | 184 | 81035 | 54701 | 42485415 |
| Lung disorder | 24.56 | 10.51 | 166 | 81053 | 47757 | 42492359 |
| Pleural effusion | 24.45 | 10.51 | 288 | 80931 | 96878 | 42443238 |
| Rheumatoid arthritis | 24.27 | 10.51 | 27 | 81192 | 42413 | 42497703 |
| Premature baby | 24.24 | 10.51 | 7 | 81212 | 23146 | 42516970 |
| Chest injury | 23.96 | 10.51 | 23 | 81196 | 1799 | 42538317 |
| Arteriosclerosis | 23.81 | 10.51 | 82 | 81137 | 17907 | 42522209 |
| Activated partial thromboplastin time prolonged | 23.28 | 10.51 | 75 | 81144 | 15828 | 42524288 |
| Accidental death | 23.18 | 10.51 | 29 | 81190 | 3054 | 42537062 |
| Anaphylactic shock | 23.04 | 10.51 | 8 | 81211 | 23509 | 42516607 |
| Therapy partial responder | 23.00 | 10.51 | 5 | 81214 | 20016 | 42520100 |
| Arteriosclerosis coronary artery | 22.89 | 10.51 | 83 | 81136 | 18594 | 42521522 |
| Granulocytopenia | 22.55 | 10.51 | 45 | 81174 | 7069 | 42533047 |
| Gangrene neonatal | 22.36 | 10.51 | 10 | 81209 | 205 | 42539911 |
| Blood phosphorus increased | 22.03 | 10.51 | 63 | 81156 | 12462 | 42527654 |
| Iron deficiency | 21.80 | 10.51 | 58 | 81161 | 11003 | 42529113 |
| Bacterial infection | 21.77 | 10.51 | 108 | 81111 | 27771 | 42512345 |
| Intestinal pseudo-obstruction | 21.58 | 10.51 | 24 | 81195 | 2231 | 42537885 |
| Gout | 21.42 | 10.51 | 108 | 81111 | 27947 | 42512169 |
| Unresponsive to stimuli | 21.31 | 10.51 | 117 | 81102 | 31286 | 42508830 |
| Peripheral artery thrombosis | 21.29 | 10.51 | 26 | 81193 | 2671 | 42537445 |
| Eosinophilia | 21.02 | 10.51 | 19 | 81200 | 32880 | 42507236 |
| Dry mouth | 20.95 | 10.51 | 139 | 81080 | 39740 | 42500376 |
| Appendicitis | 20.69 | 10.51 | 86 | 81133 | 20527 | 42519589 |
| Skin turgor decreased | 20.25 | 10.51 | 13 | 81206 | 562 | 42539554 |
| Metabolic acidosis | 20.06 | 10.51 | 43 | 81176 | 51815 | 42488301 |
| Haematocrit decreased | 19.77 | 10.51 | 124 | 81095 | 34784 | 42505332 |
| Colitis ulcerative | 19.41 | 10.51 | 13 | 81206 | 26162 | 42513954 |
| Gamma-glutamyltransferase increased | 19.33 | 10.51 | 20 | 81199 | 32477 | 42507639 |
| Dyspnoea | 19.07 | 10.51 | 1028 | 80191 | 441593 | 42098523 |
| Paraneoplastic rash | 18.84 | 10.51 | 7 | 81212 | 87 | 42540029 |
| Troponin increased | 18.72 | 10.51 | 79 | 81140 | 18983 | 42521133 |
| Spinal cord infarction | 18.52 | 10.51 | 13 | 81206 | 653 | 42539463 |
| Total lung capacity decreased | 18.42 | 10.51 | 28 | 81191 | 3542 | 42536574 |
| Poisoning | 18.31 | 10.51 | 3 | 81216 | 14696 | 42525420 |
| Blood uric acid increased | 18.13 | 10.51 | 68 | 81151 | 15479 | 42524637 |
| Epilepsy | 18.09 | 10.51 | 14 | 81205 | 26157 | 42513959 |
| Muscle spasticity | 17.96 | 10.51 | 40 | 81179 | 6782 | 42533334 |
| Toxic epidermal necrolysis | 17.63 | 10.51 | 15 | 81204 | 26735 | 42513381 |
| Peritonitis bacterial | 17.60 | 10.51 | 40 | 81179 | 6875 | 42533241 |
| Urticaria | 17.48 | 10.51 | 77 | 81142 | 73959 | 42466157 |
| Wheezing | 17.32 | 10.51 | 170 | 81049 | 54611 | 42485505 |
| Pleurothotonus | 17.29 | 10.51 | 16 | 81203 | 1195 | 42538921 |
| Cytomegalovirus infection | 16.93 | 10.51 | 22 | 81197 | 32284 | 42507832 |
| Spinal fracture | 16.92 | 10.51 | 47 | 81172 | 9143 | 42530973 |
| Decubitus ulcer | 16.80 | 10.51 | 51 | 81168 | 10426 | 42529690 |
| Therapeutic response decreased | 16.67 | 10.51 | 28 | 81191 | 36984 | 42503132 |
| Hypovitaminosis | 16.59 | 10.51 | 13 | 81206 | 773 | 42539343 |
| Rib fracture | 16.52 | 10.51 | 69 | 81150 | 16502 | 42523614 |
| Ascites | 16.07 | 10.51 | 172 | 81047 | 56506 | 42483610 |
| Injection site reaction | 16.01 | 10.51 | 5 | 81214 | 15716 | 42524400 |
| Stress | 15.88 | 10.51 | 141 | 81078 | 44071 | 42496045 |
| Incorrect dose administered | 15.83 | 10.51 | 50 | 81169 | 52924 | 42487192 |
| Chronic obstructive pulmonary disease | 15.83 | 10.51 | 187 | 81032 | 62927 | 42477189 |
| Cardiac failure congestive | 15.83 | 10.51 | 240 | 80979 | 85362 | 42454754 |
| Blood cholesterol increased | 15.77 | 10.51 | 96 | 81123 | 26645 | 42513471 |
| Synovitis | 15.77 | 10.51 | 5 | 81214 | 15562 | 42524554 |
| Hyporesponsive to stimuli | 15.74 | 10.51 | 17 | 81202 | 1529 | 42538587 |
| Product use issue | 15.70 | 10.51 | 84 | 81135 | 76667 | 42463449 |
| Metastatic renal cell carcinoma | 15.63 | 10.51 | 20 | 81199 | 2154 | 42537962 |
| Lumbar hernia | 15.63 | 10.51 | 7 | 81212 | 144 | 42539972 |
| Product prescribing error | 15.61 | 10.51 | 16 | 81203 | 26096 | 42514020 |
| Accidental exposure to product | 15.29 | 10.51 | 10 | 81209 | 20383 | 42519733 |
| Abdominal pain | 15.29 | 10.51 | 473 | 80746 | 189998 | 42350118 |
| Oral pustule | 15.23 | 10.51 | 8 | 81211 | 236 | 42539880 |
| Eczema | 15.16 | 10.51 | 26 | 81193 | 34060 | 42506056 |
| Accidental overdose | 15.15 | 10.51 | 19 | 81200 | 28311 | 42511805 |
| Metabolic encephalopathy | 15.15 | 10.51 | 32 | 81187 | 5233 | 42534883 |
| Neurogenic bladder | 15.02 | 10.51 | 20 | 81199 | 2240 | 42537876 |
| Hypoacusis | 14.99 | 10.51 | 73 | 81146 | 18629 | 42521487 |
| Injection site pain | 14.96 | 10.51 | 58 | 81161 | 57740 | 42482376 |
| White blood cell count decreased | 14.82 | 10.51 | 294 | 80925 | 110102 | 42430014 |
| Moaning | 14.81 | 10.51 | 13 | 81206 | 906 | 42539210 |
| Cellulitis | 14.81 | 10.51 | 181 | 81038 | 61404 | 42478712 |
| Acute hepatic failure | 14.78 | 10.51 | 7 | 81212 | 17066 | 42523050 |
| Sleep disorder | 14.60 | 10.51 | 148 | 81071 | 47947 | 42492169 |
| Ageusia | 14.58 | 10.51 | 52 | 81167 | 11553 | 42528563 |
| Arthritis | 14.57 | 10.51 | 37 | 81182 | 42028 | 42498088 |
| Bronchopulmonary aspergillosis allergic | 14.47 | 10.51 | 29 | 81190 | 4569 | 42535547 |
| Productive cough | 14.39 | 10.51 | 156 | 81063 | 51411 | 42488705 |
| Wrong technique in product usage process | 14.38 | 10.51 | 38 | 81181 | 42597 | 42497519 |
| Psoriatic arthropathy | 14.15 | 10.51 | 16 | 81203 | 24951 | 42515165 |
| Peripheral swelling | 14.05 | 10.51 | 246 | 80973 | 90024 | 42450092 |
| Paratracheal lymphadenopathy | 14.03 | 10.51 | 6 | 81213 | 110 | 42540006 |
| Erythema | 14.01 | 10.51 | 136 | 81083 | 108657 | 42431459 |
| Deep vein thrombosis | 13.94 | 10.51 | 215 | 81004 | 76742 | 42463374 |
| Pathological fracture | 13.90 | 10.51 | 31 | 81188 | 5262 | 42534854 |
| Pleuritic pain | 13.83 | 10.51 | 37 | 81182 | 7040 | 42533076 |
| Aspiration | 13.76 | 10.51 | 69 | 81150 | 17817 | 42522299 |
| Inappropriate schedule of product administration | 13.60 | 10.51 | 117 | 81102 | 95785 | 42444331 |
| Haemophagocytic lymphohistiocytosis | 13.58 | 10.51 | 9 | 81210 | 18213 | 42521903 |
| Intentional self-injury | 13.53 | 10.51 | 6 | 81213 | 15196 | 42524920 |
| Pain in extremity | 13.44 | 10.51 | 379 | 80840 | 150225 | 42389891 |
| Body temperature increased | 13.24 | 10.51 | 75 | 81144 | 20283 | 42519833 |
| Asthma | 13.23 | 10.51 | 179 | 81040 | 62135 | 42477981 |
| Hyperlipidaemia | 13.17 | 10.51 | 78 | 81141 | 21438 | 42518678 |
| Inflammation | 13.14 | 10.51 | 28 | 81191 | 33819 | 42506297 |
| Chills | 13.13 | 10.51 | 252 | 80967 | 93814 | 42446302 |
| Lung opacity | 12.94 | 10.51 | 32 | 81187 | 5805 | 42534311 |
| Pruritus | 12.89 | 10.51 | 268 | 80951 | 188503 | 42351613 |
| Polyneuropathy | 12.88 | 10.51 | 10 | 81209 | 18651 | 42521465 |
| Nausea | 12.85 | 10.51 | 899 | 80320 | 395900 | 42144216 |
| Drug eruption | 12.84 | 10.51 | 15 | 81204 | 23060 | 42517056 |
| Congenital hiatus hernia | 12.80 | 10.51 | 33 | 81186 | 6141 | 42533975 |
| Weight decrease neonatal | 12.73 | 10.51 | 8 | 81211 | 333 | 42539783 |
| Sitting disability | 12.67 | 10.51 | 7 | 81212 | 229 | 42539887 |
| Lactic acidosis | 12.65 | 10.51 | 44 | 81175 | 45217 | 42494899 |
| Oedema peripheral | 12.58 | 10.51 | 344 | 80875 | 135732 | 42404384 |
| Haemoglobin decreased | 12.56 | 10.51 | 336 | 80883 | 132135 | 42407981 |
| Dermatitis atopic | 12.53 | 10.51 | 4 | 81215 | 12400 | 42527716 |
| Contraindicated product administered | 12.45 | 10.51 | 18 | 81201 | 25254 | 42514862 |
| Psoriasis | 12.43 | 10.51 | 49 | 81170 | 48555 | 42491561 |
| Shock haemorrhagic | 12.13 | 10.51 | 8 | 81211 | 16234 | 42523882 |
| Impaired quality of life | 11.99 | 10.51 | 6 | 81213 | 14171 | 42525945 |
| Dysphagia | 11.98 | 10.51 | 200 | 81019 | 72519 | 42467597 |
| Cardiac failure | 11.97 | 10.51 | 138 | 81081 | 106718 | 42433398 |
| Haematochezia | 11.92 | 10.51 | 64 | 81155 | 58372 | 42481744 |
| Urinary retention | 11.91 | 10.51 | 128 | 81091 | 42086 | 42498030 |
| Postmortem blood drug level increased | 11.83 | 10.51 | 9 | 81210 | 512 | 42539604 |
| Aortic stenosis | 11.69 | 10.51 | 40 | 81179 | 8705 | 42531411 |
| Septic shock | 11.63 | 10.51 | 115 | 81104 | 91557 | 42448559 |
| Urosepsis | 11.59 | 10.51 | 58 | 81161 | 14962 | 42525154 |
| Essential thrombocythaemia | 11.58 | 10.51 | 6 | 81213 | 172 | 42539944 |
| Red blood cell count decreased | 11.58 | 10.51 | 104 | 81115 | 32611 | 42507505 |
| Aspergillus infection | 11.56 | 10.51 | 8 | 81211 | 15829 | 42524287 |
| Bone marrow failure | 11.54 | 10.51 | 29 | 81190 | 33064 | 42507052 |
| End stage renal disease | 11.44 | 10.51 | 62 | 81157 | 16496 | 42523620 |
| Muscular weakness | 11.41 | 10.51 | 223 | 80996 | 83275 | 42456841 |
| Intentional product use issue | 11.40 | 10.51 | 85 | 81134 | 71748 | 42468368 |
| Hepatotoxicity | 11.37 | 10.51 | 19 | 81200 | 25148 | 42514968 |
| Disturbance in attention | 11.35 | 10.51 | 25 | 81194 | 29841 | 42510275 |
| Anxiety | 11.32 | 10.51 | 301 | 80918 | 118259 | 42421857 |
| Myotonic dystrophy | 11.27 | 10.51 | 6 | 81213 | 182 | 42539934 |
| Band neutrophil percentage increased | 11.20 | 10.51 | 5 | 81214 | 102 | 42540014 |
| Hypervolaemia | 11.19 | 10.51 | 79 | 81140 | 23046 | 42517070 |
| Therapy non-responder | 11.13 | 10.51 | 58 | 81161 | 53301 | 42486815 |
| Hip fracture | 11.10 | 10.51 | 53 | 81166 | 13419 | 42526697 |
| Urinary incontinence | 11.06 | 10.51 | 75 | 81144 | 21593 | 42518523 |
| Drug use disorder | 11.05 | 10.51 | 3 | 81216 | 10330 | 42529786 |
| Respiratory rate decreased | 11.03 | 10.51 | 20 | 81199 | 2925 | 42537191 |
| Ecchymosis | 10.84 | 10.51 | 36 | 81183 | 7716 | 42532400 |
| Ventricular fibrillation | 10.78 | 10.51 | 96 | 81123 | 30027 | 42510089 |
| Angioedema | 10.75 | 10.51 | 43 | 81176 | 42434 | 42497682 |
| Hypophagia | 10.75 | 10.51 | 88 | 81131 | 26868 | 42513248 |
| Body height decreased | 10.75 | 10.51 | 24 | 81195 | 4076 | 42536040 |
| Post procedural complication | 10.71 | 10.51 | 50 | 81169 | 12540 | 42527576 |
| Maternal exposure during breast feeding | 10.70 | 10.51 | 14 | 81205 | 1541 | 42538575 |
| Micturition urgency | 10.68 | 10.51 | 48 | 81171 | 11850 | 42528266 |
| Tuberculosis | 10.67 | 10.51 | 3 | 81216 | 10096 | 42530020 |
| Blood lactate dehydrogenase increased | 10.61 | 10.51 | 21 | 81198 | 26060 | 42514056 |
| Eosinophil count decreased | 10.60 | 10.51 | 22 | 81197 | 3554 | 42536562 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Constipation | 572.93 | 9.81 | 1512 | 167937 | 356274 | 110063576 |
| Drug ineffective | 375.62 | 9.81 | 1145 | 168304 | 1519395 | 108900455 |
| Systemic lupus erythematosus | 313.71 | 9.81 | 19 | 169430 | 254319 | 110165531 |
| Hand deformity | 301.05 | 9.81 | 7 | 169442 | 218499 | 110201351 |
| Pemphigus | 284.15 | 9.81 | 10 | 169439 | 214560 | 110205290 |
| Synovitis | 281.69 | 9.81 | 42 | 169407 | 274050 | 110145800 |
| Duodenal ulcer perforation | 243.60 | 9.81 | 6 | 169443 | 177694 | 110242156 |
| Febrile neutropenia | 224.47 | 9.81 | 1021 | 168428 | 315746 | 110104104 |
| Helicobacter infection | 223.01 | 9.81 | 14 | 169435 | 181863 | 110237987 |
| Glossodynia | 219.14 | 9.81 | 38 | 169411 | 221966 | 110197884 |
| Folliculitis | 214.60 | 9.81 | 10 | 169439 | 167643 | 110252207 |
| Completed suicide | 205.98 | 9.81 | 58 | 169391 | 242323 | 110177527 |
| Pericarditis | 204.62 | 9.81 | 43 | 169406 | 219071 | 110200779 |
| Urinary tract infection | 189.10 | 9.81 | 993 | 168456 | 325289 | 110094561 |
| Death | 187.75 | 9.81 | 1762 | 167687 | 697107 | 109722743 |
| Therapeutic product effect decreased | 183.93 | 9.81 | 72 | 169377 | 244244 | 110175606 |
| Pulmonary embolism | 182.54 | 9.81 | 731 | 168718 | 213743 | 110206107 |
| Back pain | 181.73 | 9.81 | 1079 | 168370 | 369917 | 110049933 |
| Muscle injury | 181.52 | 9.81 | 8 | 169441 | 140799 | 110279051 |
| C-reactive protein abnormal | 175.42 | 9.81 | 5 | 169444 | 129690 | 110290160 |
| Mental status changes | 172.81 | 9.81 | 369 | 169080 | 75753 | 110344097 |
| Rheumatic fever | 172.51 | 9.81 | 3 | 169446 | 122576 | 110297274 |
| Respiratory symptom | 168.20 | 9.81 | 157 | 169292 | 14788 | 110405062 |
| Temperature regulation disorder | 162.49 | 9.81 | 144 | 169305 | 12682 | 110407168 |
| Plasma cell myeloma | 160.41 | 9.81 | 320 | 169129 | 62616 | 110357234 |
| Arthropathy | 159.65 | 9.81 | 124 | 169325 | 287398 | 110132452 |
| Maternal exposure during pregnancy | 154.55 | 9.81 | 100 | 169349 | 254783 | 110165067 |
| Irritable bowel syndrome | 149.70 | 9.81 | 34 | 169415 | 164181 | 110255669 |
| Discomfort | 147.79 | 9.81 | 72 | 169377 | 214635 | 110205215 |
| Pneumonia aspiration | 144.85 | 9.81 | 358 | 169091 | 80875 | 110338975 |
| Off label use | 144.75 | 9.81 | 1537 | 167912 | 1498648 | 108921202 |
| Hypoxia | 140.88 | 9.81 | 478 | 168971 | 129037 | 110290813 |
| Psoriatic arthropathy | 140.02 | 9.81 | 63 | 169386 | 196698 | 110223152 |
| Wound | 139.40 | 9.81 | 94 | 169355 | 234343 | 110185507 |
| Sleep disorder due to general medical condition, insomnia type | 136.17 | 9.81 | 6 | 169443 | 105637 | 110314213 |
| Lip dry | 134.83 | 9.81 | 4 | 169445 | 100079 | 110319771 |
| C-reactive protein increased | 130.07 | 9.81 | 87 | 169362 | 217832 | 110202018 |
| Facet joint syndrome | 126.47 | 9.81 | 5 | 169444 | 96823 | 110323027 |
| Food allergy | 125.64 | 9.81 | 154 | 169295 | 19794 | 110400056 |
| Impaired healing | 125.06 | 9.81 | 73 | 169376 | 196644 | 110223206 |
| Pulmonary vasculitis | 123.99 | 9.81 | 93 | 169356 | 6467 | 110413383 |
| Liver injury | 120.53 | 9.81 | 40 | 169409 | 150373 | 110269477 |
| Neuritis | 120.44 | 9.81 | 96 | 169353 | 7303 | 110412547 |
| Alopecia | 117.16 | 9.81 | 239 | 169210 | 364514 | 110055336 |
| Swollen joint count increased | 113.97 | 9.81 | 3 | 169446 | 83658 | 110336192 |
| Obstructive airways disorder | 108.54 | 9.81 | 227 | 169222 | 45922 | 110373928 |
| Foetal death | 107.80 | 9.81 | 128 | 169321 | 15917 | 110403933 |
| Upper respiratory tract infection | 107.20 | 9.81 | 442 | 169007 | 130886 | 110288964 |
| Type 2 diabetes mellitus | 106.78 | 9.81 | 70 | 169379 | 177162 | 110242688 |
| Fall | 103.14 | 9.81 | 1393 | 168056 | 602089 | 109817761 |
| Drug abuse | 102.98 | 9.81 | 73 | 169376 | 177338 | 110242512 |
| Total lung capacity decreased | 102.56 | 9.81 | 86 | 169363 | 7028 | 110412822 |
| Blood calcium increased | 102.05 | 9.81 | 132 | 169317 | 17908 | 110401942 |
| Deep vein thrombosis | 102.01 | 9.81 | 455 | 168994 | 139432 | 110280418 |
| Grip strength decreased | 101.88 | 9.81 | 5 | 169444 | 80169 | 110339681 |
| Toxicity to various agents | 100.75 | 9.81 | 387 | 169062 | 480168 | 109939682 |
| Ill-defined disorder | 99.98 | 9.81 | 58 | 169391 | 156795 | 110263055 |
| Urticaria | 98.96 | 9.81 | 213 | 169236 | 318644 | 110101206 |
| Intentional overdose | 98.12 | 9.81 | 40 | 169409 | 132461 | 110287389 |
| Blister | 97.48 | 9.81 | 123 | 169326 | 227253 | 110192597 |
| Myelosuppression | 95.62 | 9.81 | 15 | 169434 | 94325 | 110325525 |
| Pleural effusion | 93.48 | 9.81 | 527 | 168922 | 177182 | 110242668 |
| Inflammation | 93.21 | 9.81 | 95 | 169354 | 193143 | 110226707 |
| Pneumonia | 92.06 | 9.81 | 1868 | 167581 | 874846 | 109545004 |
| Sepsis | 91.98 | 9.81 | 834 | 168615 | 326512 | 110093338 |
| Dehydration | 91.07 | 9.81 | 736 | 168713 | 278775 | 110141075 |
| Fibromyalgia | 90.72 | 9.81 | 77 | 169372 | 170832 | 110249018 |
| Total lung capacity abnormal | 88.91 | 9.81 | 66 | 169383 | 4517 | 110415333 |
| Thrombosis | 88.90 | 9.81 | 366 | 169083 | 108296 | 110311554 |
| Peripheral venous disease | 88.44 | 9.81 | 12 | 169437 | 84105 | 110335745 |
| Failure to thrive | 87.45 | 9.81 | 106 | 169343 | 13468 | 110406382 |
| Bronchopulmonary aspergillosis allergic | 86.24 | 9.81 | 84 | 169365 | 8342 | 110411508 |
| Lung opacity | 83.36 | 9.81 | 96 | 169353 | 11556 | 110408294 |
| Fluid retention | 83.02 | 9.81 | 325 | 169124 | 93982 | 110325868 |
| Abdominal discomfort | 81.99 | 9.81 | 318 | 169131 | 393540 | 110026310 |
| Hyponatraemia | 80.85 | 9.81 | 591 | 168858 | 217062 | 110202788 |
| Neurological symptom | 80.27 | 9.81 | 109 | 169340 | 15499 | 110404351 |
| Joint swelling | 79.66 | 9.81 | 378 | 169071 | 442467 | 109977383 |
| Haemoptysis | 79.02 | 9.81 | 265 | 169184 | 71089 | 110348761 |
| Salpingo-oophorectomy unilateral | 78.96 | 9.81 | 34 | 169415 | 797 | 110419053 |
| Gastrooesophageal reflux disease | 76.45 | 9.81 | 505 | 168944 | 179471 | 110240379 |
| Epilepsy | 76.26 | 9.81 | 29 | 169420 | 100180 | 110319670 |
| Live birth | 75.26 | 9.81 | 9 | 169440 | 69475 | 110350375 |
| Intentional product use issue | 74.11 | 9.81 | 169 | 169280 | 247737 | 110172113 |
| Gastrointestinal disorder | 72.28 | 9.81 | 165 | 169284 | 241787 | 110178063 |
| Pulmonary malformation | 72.03 | 9.81 | 23 | 169426 | 222 | 110419628 |
| Dyspnoea | 71.82 | 9.81 | 2210 | 167239 | 1104662 | 109315188 |
| Immunodeficiency | 70.10 | 9.81 | 172 | 169277 | 38666 | 110381184 |
| Treatment failure | 69.85 | 9.81 | 206 | 169243 | 277028 | 110142822 |
| Eosinophilic granulomatosis with polyangiitis | 69.74 | 9.81 | 84 | 169365 | 10602 | 110409248 |
| Blood test abnormal | 68.96 | 9.81 | 142 | 169307 | 28412 | 110391438 |
| Conjunctivitis allergic | 68.89 | 9.81 | 68 | 169381 | 6863 | 110412987 |
| Fatigue | 68.15 | 9.81 | 2386 | 167063 | 1213572 | 109206278 |
| Blepharospasm | 67.88 | 9.81 | 4 | 169445 | 54847 | 110365003 |
| Contraindicated product administered | 67.34 | 9.81 | 178 | 169271 | 248089 | 110171761 |
| Small intestinal obstruction | 67.23 | 9.81 | 151 | 169298 | 32062 | 110387788 |
| Somnolence | 67.06 | 9.81 | 724 | 168725 | 296725 | 110123125 |
| Oedema peripheral | 66.86 | 9.81 | 784 | 168665 | 327876 | 110091974 |
| Mobility decreased | 66.10 | 9.81 | 168 | 169281 | 237254 | 110182596 |
| Pleuritic pain | 65.86 | 9.81 | 101 | 169348 | 16039 | 110403811 |
| General physical health deterioration | 65.85 | 9.81 | 382 | 169067 | 424913 | 109994937 |
| Condition aggravated | 65.66 | 9.81 | 765 | 168684 | 734071 | 109685779 |
| Aspiration | 64.71 | 9.81 | 144 | 169305 | 30389 | 110389461 |
| Proctalgia | 64.48 | 9.81 | 90 | 169359 | 13132 | 110406718 |
| Haemoglobin decreased | 64.46 | 9.81 | 623 | 168826 | 248104 | 110171746 |
| Intestinal pseudo-obstruction | 64.37 | 9.81 | 48 | 169401 | 3308 | 110416542 |
| IVth nerve paralysis | 62.74 | 9.81 | 27 | 169422 | 632 | 110419218 |
| Spirometry abnormal | 62.34 | 9.81 | 58 | 169391 | 5439 | 110414411 |
| Injection site reaction | 61.06 | 9.81 | 30 | 169419 | 89040 | 110330810 |
| Hospice care | 60.98 | 9.81 | 85 | 169364 | 12388 | 110407462 |
| Obesity | 60.23 | 9.81 | 51 | 169398 | 113300 | 110306550 |
| Mite allergy | 59.67 | 9.81 | 58 | 169391 | 5745 | 110414105 |
| Product use in unapproved indication | 59.46 | 9.81 | 421 | 169028 | 446956 | 109972894 |
| Red blood cell sedimentation rate increased | 59.01 | 9.81 | 23 | 169426 | 78279 | 110341571 |
| Drug ineffective for unapproved indication | 58.77 | 9.81 | 43 | 169406 | 102795 | 110317055 |
| Mycotic allergy | 58.41 | 9.81 | 58 | 169391 | 5896 | 110413954 |
| Dust allergy | 58.03 | 9.81 | 58 | 169391 | 5943 | 110413907 |
| Stomatitis | 56.98 | 9.81 | 217 | 169232 | 270025 | 110149825 |
| Sinusitis fungal | 56.91 | 9.81 | 41 | 169408 | 2679 | 110417171 |
| Colitis ulcerative | 56.23 | 9.81 | 24 | 169425 | 77339 | 110342511 |
| Hypotension | 56.09 | 9.81 | 1120 | 168329 | 522729 | 109897121 |
| Night sweats | 55.84 | 9.81 | 74 | 169375 | 133909 | 110285941 |
| Chronic obstructive pulmonary disease | 55.59 | 9.81 | 321 | 169128 | 108837 | 110311013 |
| Asthenia | 55.57 | 9.81 | 1415 | 168034 | 687584 | 109732266 |
| Joint range of motion decreased | 55.29 | 9.81 | 63 | 169386 | 121769 | 110298081 |
| Swelling | 53.95 | 9.81 | 316 | 169133 | 350725 | 110069125 |
| Granulocytopenia | 53.91 | 9.81 | 81 | 169368 | 12634 | 110407216 |
| Arthralgia | 53.63 | 9.81 | 856 | 168593 | 778776 | 109641074 |
| Nail disorder | 52.77 | 9.81 | 12 | 169437 | 57923 | 110361927 |
| Analgesic therapy | 52.08 | 9.81 | 60 | 169389 | 7224 | 110412626 |
| Dislocation of vertebra | 51.73 | 9.81 | 4 | 169445 | 43717 | 110376133 |
| Unresponsive to stimuli | 51.48 | 9.81 | 214 | 169235 | 63576 | 110356274 |
| Hepatocellular injury | 51.43 | 9.81 | 8 | 169441 | 50634 | 110369216 |
| Embolism venous | 51.27 | 9.81 | 50 | 169399 | 4973 | 110414877 |
| Antineutrophil cytoplasmic antibody positive | 50.82 | 9.81 | 50 | 169399 | 5026 | 110414824 |
| Pulmonary alveolar haemorrhage | 50.78 | 9.81 | 102 | 169347 | 20048 | 110399802 |
| Cellulitis | 50.74 | 9.81 | 349 | 169100 | 125667 | 110294183 |
| Therapy non-responder | 50.52 | 9.81 | 103 | 169346 | 157204 | 110262646 |
| Drug therapy | 50.36 | 9.81 | 59 | 169390 | 7232 | 110412618 |
| Peritonitis bacterial | 50.33 | 9.81 | 71 | 169378 | 10462 | 110409388 |
| Cardiac failure congestive | 49.89 | 9.81 | 399 | 169050 | 150601 | 110269249 |
| Autoimmune disorder | 49.74 | 9.81 | 19 | 169430 | 65464 | 110354386 |
| Vasculitis | 49.68 | 9.81 | 144 | 169305 | 35729 | 110384121 |
| Hiatus hernia | 49.55 | 9.81 | 122 | 169327 | 27484 | 110392366 |
| Onychomadesis | 49.24 | 9.81 | 6 | 169443 | 45657 | 110374193 |
| Lung cyst | 48.86 | 9.81 | 21 | 169428 | 490 | 110419360 |
| Suicide attempt | 48.53 | 9.81 | 52 | 169397 | 103342 | 110316508 |
| Myasthenia gravis | 48.48 | 9.81 | 104 | 169345 | 21407 | 110398443 |
| Abdominal pain | 48.48 | 9.81 | 1077 | 168372 | 511912 | 109907938 |
| Haemorrhoids | 48.25 | 9.81 | 142 | 169307 | 35530 | 110384320 |
| Lethargy | 48.18 | 9.81 | 276 | 169173 | 93300 | 110326550 |
| Bone erosion | 47.84 | 9.81 | 7 | 169442 | 46364 | 110373486 |
| Full blood count abnormal | 47.58 | 9.81 | 191 | 169258 | 55861 | 110363989 |
| Neuralgia | 47.57 | 9.81 | 173 | 169276 | 48305 | 110371545 |
| Hyperphosphataemia | 47.51 | 9.81 | 88 | 169361 | 16293 | 110403557 |
| Capillaritis | 47.04 | 9.81 | 35 | 169414 | 2404 | 110417446 |
| Appendicolith | 47.01 | 9.81 | 81 | 169368 | 14174 | 110405676 |
| X-ray abnormal | 46.51 | 9.81 | 3 | 169446 | 38114 | 110381736 |
| Anal inflammation | 46.32 | 9.81 | 35 | 169414 | 2461 | 110417389 |
| Full blood count decreased | 45.56 | 9.81 | 130 | 169319 | 31969 | 110387881 |
| Infection | 44.68 | 9.81 | 348 | 169101 | 361852 | 110057998 |
| Rash erythematous | 44.54 | 9.81 | 245 | 169204 | 81587 | 110338263 |
| Diverticulum | 44.52 | 9.81 | 83 | 169366 | 15443 | 110404407 |
| Adjustment disorder with depressed mood | 44.41 | 9.81 | 7 | 169442 | 43876 | 110375974 |
| Nausea | 44.34 | 9.81 | 2315 | 167134 | 1233375 | 109186475 |
| Hypersomnia | 44.14 | 9.81 | 118 | 169331 | 27943 | 110391907 |
| SARS-CoV-2 test negative | 44.01 | 9.81 | 32 | 169417 | 2121 | 110417729 |
| White blood cell count decreased | 43.90 | 9.81 | 541 | 168908 | 228849 | 110191001 |
| Drug reaction with eosinophilia and systemic symptoms | 43.54 | 9.81 | 37 | 169412 | 82058 | 110337792 |
| Interstitial lung disease | 43.25 | 9.81 | 93 | 169356 | 139241 | 110280609 |
| Anticoagulant therapy | 43.20 | 9.81 | 47 | 169402 | 5314 | 110414536 |
| Haematocrit decreased | 42.97 | 9.81 | 208 | 169241 | 65909 | 110353941 |
| Hypophosphataemia | 42.91 | 9.81 | 130 | 169319 | 33052 | 110386798 |
| Sleep disorder therapy | 42.78 | 9.81 | 55 | 169394 | 7416 | 110412434 |
| Blood phosphorus increased | 42.73 | 9.81 | 84 | 169365 | 16256 | 110403594 |
| Drug intolerance | 42.40 | 9.81 | 408 | 169041 | 406104 | 110013746 |
| Wound infection | 41.51 | 9.81 | 52 | 169397 | 96413 | 110323437 |
| Hypercholesterolaemia | 41.18 | 9.81 | 47 | 169402 | 90790 | 110329060 |
| Poor sucking reflex | 40.85 | 9.81 | 13 | 169436 | 124 | 110419726 |
| Antacid therapy | 40.61 | 9.81 | 46 | 169403 | 5438 | 110414412 |
| Hyperhidrosis | 40.39 | 9.81 | 452 | 168997 | 186846 | 110233004 |
| Diastolic dysfunction | 40.28 | 9.81 | 70 | 169379 | 12334 | 110407516 |
| Normochromic normocytic anaemia | 40.22 | 9.81 | 72 | 169377 | 12985 | 110406865 |
| Nasopharyngitis | 40.20 | 9.81 | 398 | 169051 | 393963 | 110025887 |
| Pregnancy | 40.17 | 9.81 | 14 | 169435 | 51053 | 110368797 |
| Hypervolaemia | 39.97 | 9.81 | 166 | 169283 | 49294 | 110370556 |
| Carbuncle | 39.90 | 9.81 | 26 | 169423 | 1441 | 110418409 |
| Blood cholesterol increased | 39.18 | 9.81 | 148 | 169301 | 184637 | 110235213 |
| Sputum increased | 38.83 | 9.81 | 46 | 169403 | 5705 | 110414145 |
| Respiratory tract malformation | 38.83 | 9.81 | 12 | 169437 | 103 | 110419747 |
| Hepatic enzyme increased | 38.79 | 9.81 | 310 | 169139 | 320582 | 110099268 |
| Blood potassium decreased | 38.66 | 9.81 | 175 | 169274 | 53939 | 110365911 |
| Drug resistance | 38.62 | 9.81 | 19 | 169430 | 56355 | 110363495 |
| Forced expiratory volume decreased | 38.48 | 9.81 | 71 | 169378 | 13105 | 110406745 |
| Blood creatinine increased | 38.37 | 9.81 | 439 | 169010 | 182450 | 110237400 |
| Retinitis | 38.13 | 9.81 | 3 | 169446 | 32324 | 110387526 |
| Ascites | 37.93 | 9.81 | 258 | 169191 | 92550 | 110327300 |
| Anti-neutrophil cytoplasmic antibody positive vasculitis | 37.69 | 9.81 | 44 | 169405 | 5373 | 110414477 |
| Cestode infection | 37.36 | 9.81 | 15 | 169434 | 293 | 110419557 |
| Monoclonal immunoglobulin present | 37.22 | 9.81 | 31 | 169418 | 2509 | 110417341 |
| Anaemia | 36.83 | 9.81 | 1098 | 168351 | 545988 | 109873862 |
| Acute respiratory failure | 36.81 | 9.81 | 219 | 169230 | 75041 | 110344809 |
| Iron deficiency | 36.77 | 9.81 | 85 | 169364 | 18391 | 110401459 |
| Hypophagia | 36.71 | 9.81 | 169 | 169280 | 52457 | 110367393 |
| Respiratory failure | 36.63 | 9.81 | 497 | 168952 | 214835 | 110205015 |
| Decubitus ulcer | 36.41 | 9.81 | 84 | 169365 | 18152 | 110401698 |
| Abdominal distension | 35.70 | 9.81 | 418 | 169031 | 174685 | 110245165 |
| Road traffic accident | 35.61 | 9.81 | 69 | 169380 | 107329 | 110312521 |
| Cholestasis | 35.55 | 9.81 | 28 | 169421 | 64490 | 110355360 |
| Dysphagia | 35.10 | 9.81 | 375 | 169074 | 153225 | 110266625 |
| Creatinine renal clearance increased | 34.98 | 9.81 | 35 | 169414 | 3590 | 110416260 |
| Drug interaction | 34.73 | 9.81 | 548 | 168901 | 499635 | 109920215 |
| Therapeutic response decreased | 34.68 | 9.81 | 59 | 169390 | 96440 | 110323410 |
| Tremor | 34.50 | 9.81 | 467 | 168982 | 201765 | 110218085 |
| Atrial fibrillation | 34.27 | 9.81 | 518 | 168931 | 229124 | 110190726 |
| Tricuspid valve incompetence | 34.19 | 9.81 | 97 | 169352 | 23776 | 110396074 |
| Lupus-like syndrome | 34.19 | 9.81 | 10 | 169439 | 40782 | 110379068 |
| Activated partial thromboplastin time prolonged | 34.12 | 9.81 | 93 | 169356 | 22275 | 110397575 |
| Hip fracture | 34.12 | 9.81 | 125 | 169324 | 35026 | 110384824 |
| Failure to suspend medication | 33.82 | 9.81 | 16 | 169433 | 470 | 110419380 |
| Migraine | 33.53 | 9.81 | 142 | 169307 | 171510 | 110248340 |
| Autonomic dysreflexia | 33.42 | 9.81 | 16 | 169433 | 483 | 110419367 |
| Coeliac disease | 33.38 | 9.81 | 143 | 169306 | 43044 | 110376806 |
| Hepatitis | 33.35 | 9.81 | 54 | 169395 | 90000 | 110329850 |
| Balance disorder | 33.20 | 9.81 | 298 | 169151 | 116262 | 110303588 |
| Asthma | 32.99 | 9.81 | 553 | 168896 | 249738 | 110170112 |
| Hallucination | 32.94 | 9.81 | 267 | 169182 | 101165 | 110318685 |
| Epistaxis | 32.50 | 9.81 | 324 | 169125 | 130048 | 110289802 |
| Troponin increased | 32.46 | 9.81 | 110 | 169339 | 29656 | 110390194 |
| Vomiting | 32.15 | 9.81 | 1704 | 167745 | 908971 | 109510879 |
| Adverse event | 31.83 | 9.81 | 75 | 169374 | 108734 | 110311116 |
| Hypothyroidism | 31.81 | 9.81 | 206 | 169243 | 72693 | 110347157 |
| Pulmonary mass | 31.57 | 9.81 | 127 | 169322 | 37174 | 110382676 |
| Onychomycosis | 31.29 | 9.81 | 10 | 169439 | 38521 | 110381329 |
| International normalised ratio increased | 31.27 | 9.81 | 234 | 169215 | 86538 | 110333312 |
| Arteriosclerosis coronary artery | 31.16 | 9.81 | 97 | 169352 | 25021 | 110394829 |
| Therapeutic product effect incomplete | 30.98 | 9.81 | 208 | 169241 | 223597 | 110196253 |
| Urinary incontinence | 30.96 | 9.81 | 152 | 169297 | 48435 | 110371415 |
| Pruritus | 30.75 | 9.81 | 668 | 168781 | 580892 | 109838958 |
| Premenstrual syndrome | 30.48 | 9.81 | 16 | 169433 | 590 | 110419260 |
| Rales | 30.20 | 9.81 | 95 | 169354 | 24644 | 110395206 |
| Frequent bowel movements | 30.18 | 9.81 | 39 | 169410 | 71351 | 110348499 |
| Anaphylactic shock | 30.17 | 9.81 | 21 | 169428 | 51525 | 110368325 |
| Chills | 30.04 | 9.81 | 434 | 169015 | 190146 | 110229704 |
| Lower limb fracture | 30.00 | 9.81 | 43 | 169406 | 75305 | 110344545 |
| Exposure via breast milk | 29.89 | 9.81 | 19 | 169430 | 1009 | 110418841 |
| Rheumatoid arthritis | 29.84 | 9.81 | 304 | 169145 | 299309 | 110120541 |
| Gout | 29.76 | 9.81 | 123 | 169326 | 36443 | 110383407 |
| End stage renal disease | 29.54 | 9.81 | 86 | 169363 | 21387 | 110398463 |
| IgA nephropathy | 29.46 | 9.81 | 30 | 169419 | 3143 | 110416707 |
| Platelet count decreased | 29.22 | 9.81 | 506 | 168943 | 229937 | 110189913 |
| Emphysema | 29.00 | 9.81 | 81 | 169368 | 19675 | 110400175 |
| Neutrophil count decreased | 28.92 | 9.81 | 298 | 169151 | 120643 | 110299207 |
| Hyperlipidaemia | 28.72 | 9.81 | 120 | 169329 | 35728 | 110384122 |
| Musculoskeletal pain | 28.49 | 9.81 | 164 | 169285 | 182859 | 110236991 |
| Renal function test abnormal | 28.42 | 9.81 | 50 | 169399 | 8896 | 110410954 |
| Appendicitis | 28.28 | 9.81 | 102 | 169347 | 28362 | 110391488 |
| Accident | 28.27 | 9.81 | 56 | 169393 | 10896 | 110408954 |
| Disease progression | 28.18 | 9.81 | 528 | 168921 | 243506 | 110176344 |
| Cholelithiasis | 28.15 | 9.81 | 180 | 169269 | 63242 | 110356608 |
| Red blood cell count decreased | 27.98 | 9.81 | 185 | 169264 | 65738 | 110354112 |
| Productive cough | 27.97 | 9.81 | 283 | 169166 | 114022 | 110305828 |
| Exostosis | 27.87 | 9.81 | 18 | 169431 | 45938 | 110373912 |
| Lactation disorder | 27.76 | 9.81 | 12 | 169437 | 284 | 110419566 |
| Gastrointestinal haemorrhage | 27.72 | 9.81 | 381 | 169068 | 165137 | 110254713 |
| Hypersensitivity | 27.56 | 9.81 | 444 | 169005 | 403554 | 110016296 |
| Burkholderia test positive | 27.25 | 9.81 | 15 | 169434 | 609 | 110419241 |
| Rash | 26.84 | 9.81 | 1008 | 168441 | 819956 | 109599894 |
| Magnesium deficiency | 26.61 | 9.81 | 16 | 169433 | 769 | 110419081 |
| Paraesthesia | 26.54 | 9.81 | 283 | 169166 | 276238 | 110143612 |
| Drug tolerance decreased | 26.54 | 9.81 | 5 | 169444 | 27535 | 110392315 |
| Hip arthroplasty | 26.27 | 9.81 | 28 | 169421 | 55785 | 110364065 |
| Sputum discoloured | 25.97 | 9.81 | 98 | 169351 | 27847 | 110392003 |
| Accidental exposure to product | 25.95 | 9.81 | 23 | 169426 | 49985 | 110369865 |
| Injection site erythema | 25.92 | 9.81 | 67 | 169382 | 94109 | 110325741 |
| Arteriosclerosis | 25.68 | 9.81 | 90 | 169359 | 24677 | 110395173 |
| Polymenorrhoea | 25.68 | 9.81 | 18 | 169431 | 1126 | 110418724 |
| Chest pain | 25.46 | 9.81 | 756 | 168693 | 375619 | 110044231 |
| Injury | 25.42 | 9.81 | 163 | 169286 | 177102 | 110242748 |
| Product quality issue | 25.34 | 9.81 | 50 | 169399 | 77249 | 110342601 |
| Sinusitis | 25.22 | 9.81 | 312 | 169137 | 296376 | 110123474 |
| Aortic stenosis | 24.81 | 9.81 | 59 | 169390 | 13000 | 110406850 |
| Hypothalamo-pituitary disorder | 24.78 | 9.81 | 26 | 169423 | 2820 | 110417030 |
| Product label confusion | 24.40 | 9.81 | 3 | 169446 | 22674 | 110397176 |
| Infusion related reaction | 24.33 | 9.81 | 424 | 169025 | 380738 | 110039112 |
| Fungal infection | 24.31 | 9.81 | 147 | 169302 | 50659 | 110369191 |
| Atelectasis | 24.22 | 9.81 | 116 | 169333 | 36596 | 110383254 |
| Retching | 24.02 | 9.81 | 83 | 169366 | 22599 | 110397251 |
| Product use issue | 23.85 | 9.81 | 335 | 169114 | 311360 | 110108490 |
| Hepatic cirrhosis | 23.70 | 9.81 | 42 | 169407 | 67584 | 110352266 |
| Eosinophil count decreased | 23.63 | 9.81 | 37 | 169412 | 5981 | 110413869 |
| Ecchymosis | 23.43 | 9.81 | 69 | 169380 | 17269 | 110402581 |
| Back injury | 23.19 | 9.81 | 23 | 169426 | 47376 | 110372474 |
| Bacterial infection | 23.18 | 9.81 | 135 | 169314 | 45901 | 110373949 |
| Weight increased | 23.04 | 9.81 | 479 | 168970 | 419165 | 110000685 |
| Drug-induced liver injury | 23.03 | 9.81 | 100 | 169349 | 119967 | 110299883 |
| Sciatica | 23 | 9.81 | 69 | 169380 | 92330 | 110327520 |
| Supraventricular tachycardia | 22.99 | 9.81 | 86 | 169363 | 24336 | 110395514 |
| Abortion spontaneous | 22.82 | 9.81 | 12 | 169437 | 34270 | 110385580 |
| Hysterectomy | 22.79 | 9.81 | 43 | 169406 | 8071 | 110411779 |
| Chest injury | 22.58 | 9.81 | 27 | 169422 | 3382 | 110416468 |
| Menstruation delayed | 22.44 | 9.81 | 20 | 169429 | 1774 | 110418076 |
| Maternal exposure during breast feeding | 22.41 | 9.81 | 30 | 169419 | 4208 | 110415642 |
| Blood uric acid increased | 22.12 | 9.81 | 78 | 169371 | 21451 | 110398399 |
| Injection site swelling | 22.00 | 9.81 | 38 | 169411 | 61752 | 110358098 |
| Drug eruption | 21.98 | 9.81 | 30 | 169419 | 53629 | 110366221 |
| Body height decreased | 21.47 | 9.81 | 49 | 169400 | 10514 | 110409336 |
| Foetal exposure timing unspecified | 21.44 | 9.81 | 7 | 169442 | 73 | 110419777 |
| Gait inability | 21.33 | 9.81 | 122 | 169327 | 136254 | 110283596 |
| Knee arthroplasty | 21.29 | 9.81 | 42 | 169407 | 64906 | 110354944 |
| Dental restoration failure | 21.10 | 9.81 | 16 | 169433 | 1131 | 110418719 |
| Injection site pain | 20.97 | 9.81 | 173 | 169276 | 177749 | 110242101 |
| Myoclonus | 20.86 | 9.81 | 103 | 169346 | 32895 | 110386955 |
| Lichen sclerosus | 20.84 | 9.81 | 16 | 169433 | 1152 | 110418698 |
| Sleep apnoea syndrome | 20.62 | 9.81 | 119 | 169330 | 40328 | 110379522 |
| Lactic acidosis | 20.54 | 9.81 | 73 | 169376 | 92738 | 110327112 |
| Pneumonitis | 20.45 | 9.81 | 193 | 169256 | 76338 | 110343512 |
| Post procedural complication | 20.40 | 9.81 | 88 | 169361 | 26570 | 110393280 |
| Drooling | 20.26 | 9.81 | 38 | 169411 | 7101 | 110412749 |
| Paraneoplastic rash | 20.26 | 9.81 | 7 | 169442 | 88 | 110419762 |
| Haemorrhage intracranial | 20.18 | 9.81 | 93 | 169356 | 28876 | 110390974 |
| Ventricular fibrillation | 20.06 | 9.81 | 120 | 169329 | 41193 | 110378657 |
| Feeling hot | 19.94 | 9.81 | 72 | 169377 | 91034 | 110328816 |
| Hepatic function abnormal | 19.92 | 9.81 | 70 | 169379 | 89225 | 110330625 |
| Maternal exposure timing unspecified | 19.86 | 9.81 | 4 | 169445 | 21009 | 110398841 |
| Cytomegalovirus infection | 19.83 | 9.81 | 33 | 169416 | 54411 | 110365439 |
| Heart rate increased | 19.76 | 9.81 | 320 | 169129 | 143514 | 110276336 |
| Product prescribing error | 19.74 | 9.81 | 30 | 169419 | 51301 | 110368549 |
| Ear infection | 19.36 | 9.81 | 42 | 169407 | 62690 | 110357160 |
| Liver disorder | 19.28 | 9.81 | 133 | 169316 | 142110 | 110277740 |
| Cerebrovascular accident | 19.15 | 9.81 | 387 | 169062 | 180897 | 110238953 |
| Lip pruritus | 19.09 | 9.81 | 16 | 169433 | 1306 | 110418544 |
| Medication error | 18.87 | 9.81 | 90 | 169359 | 105276 | 110314574 |
| Ileus | 18.78 | 9.81 | 95 | 169354 | 30634 | 110389216 |
| Acute generalised exanthematous pustulosis | 18.73 | 9.81 | 5 | 169444 | 21659 | 110398191 |
| Metastatic renal cell carcinoma | 18.70 | 9.81 | 21 | 169428 | 2459 | 110417391 |
| Congenital hiatus hernia | 18.62 | 9.81 | 34 | 169415 | 6225 | 110413625 |
| Bone marrow failure | 18.46 | 9.81 | 38 | 169411 | 57810 | 110362040 |
| Arthritis | 18.39 | 9.81 | 166 | 169283 | 167420 | 110252430 |
| Haemophagocytic lymphohistiocytosis | 18.28 | 9.81 | 13 | 169436 | 31546 | 110388304 |
| Hypoaesthesia | 18.03 | 9.81 | 356 | 169093 | 313867 | 110105983 |
| Thyroid atrophy | 18.03 | 9.81 | 9 | 169440 | 298 | 110419552 |
| Drug use disorder | 18.03 | 9.81 | 3 | 169446 | 18071 | 110401779 |
| Excessive eye blinking | 17.95 | 9.81 | 18 | 169431 | 1852 | 110417998 |
| Transfusion | 17.91 | 9.81 | 82 | 169367 | 25390 | 110394460 |
| Metabolic encephalopathy | 17.89 | 9.81 | 47 | 169402 | 11013 | 110408837 |
| Overweight | 17.84 | 9.81 | 34 | 169415 | 6430 | 110413420 |
| Urinary retention | 17.76 | 9.81 | 174 | 169275 | 69509 | 110350341 |
| Uterine perforation | 17.69 | 9.81 | 35 | 169414 | 6805 | 110413045 |
| Taste disorder | 17.62 | 9.81 | 47 | 169402 | 65340 | 110354510 |
| Diabetes mellitus | 17.56 | 9.81 | 231 | 169218 | 99150 | 110320700 |
| Wrist deformity | 17.52 | 9.81 | 23 | 169426 | 3166 | 110416684 |
| Musculoskeletal chest pain | 17.50 | 9.81 | 89 | 169360 | 28758 | 110391092 |
| Blood calcium decreased | 17.33 | 9.81 | 104 | 169345 | 35741 | 110384109 |
| Musculoskeletal stiffness | 17.30 | 9.81 | 313 | 169136 | 279509 | 110140341 |
| Adverse drug reaction | 17.29 | 9.81 | 93 | 169356 | 105466 | 110314384 |
| Neurogenic bladder | 16.93 | 9.81 | 29 | 169420 | 5050 | 110414800 |
| Dyspepsia | 16.91 | 9.81 | 199 | 169250 | 190766 | 110229084 |
| Epiglottic erythema | 16.84 | 9.81 | 6 | 169443 | 83 | 110419767 |
| Ageusia | 16.71 | 9.81 | 67 | 169382 | 19578 | 110400272 |
| Toxic epidermal necrolysis | 16.67 | 9.81 | 39 | 169410 | 56688 | 110363162 |
| Pneumonia viral | 16.63 | 9.81 | 46 | 169403 | 11111 | 110408739 |
| Carbohydrate antigen 125 increased | 16.59 | 9.81 | 20 | 169429 | 2527 | 110417323 |
| Micturition urgency | 16.53 | 9.81 | 66 | 169383 | 19254 | 110400596 |
| Neuropathy peripheral | 16.45 | 9.81 | 375 | 169074 | 178902 | 110240948 |
| Lumbar hernia | 16.38 | 9.81 | 7 | 169442 | 161 | 110419689 |
| Intentional self-injury | 16.29 | 9.81 | 20 | 169429 | 37409 | 110382441 |
| Fibrosis | 16.14 | 9.81 | 36 | 169413 | 7606 | 110412244 |
| Injection site pruritus | 16.08 | 9.81 | 34 | 169415 | 51224 | 110368626 |
| Painful respiration | 16.07 | 9.81 | 24 | 169425 | 3723 | 110416127 |
| Accidental death | 15.92 | 9.81 | 28 | 169421 | 4981 | 110414869 |
| Posture abnormal | 15.67 | 9.81 | 26 | 169423 | 4412 | 110415438 |
| Intestinal obstruction | 15.63 | 9.81 | 137 | 169312 | 53090 | 110366760 |
| Limb injury | 15.60 | 9.81 | 105 | 169344 | 37531 | 110382319 |
| Iron deficiency anaemia | 15.54 | 9.81 | 92 | 169357 | 31467 | 110388383 |
| Hot flush | 15.44 | 9.81 | 162 | 169287 | 65874 | 110353976 |
| Impaired quality of life | 15.34 | 9.81 | 14 | 169435 | 30003 | 110389847 |
| Spinal cord infarction | 15.26 | 9.81 | 13 | 169436 | 1085 | 110418765 |
| Orthostatic hypotension | 15.25 | 9.81 | 162 | 169287 | 66087 | 110353763 |
| Dyspnoea exertional | 15.23 | 9.81 | 234 | 169215 | 103826 | 110316024 |
| Oesophageal irritation | 15.19 | 9.81 | 8 | 169441 | 297 | 110419553 |
| Calculus bladder | 15.16 | 9.81 | 16 | 169433 | 1748 | 110418102 |
| Impaired work ability | 15.15 | 9.81 | 11 | 169438 | 26408 | 110393442 |
| Drug hypersensitivity | 15.15 | 9.81 | 556 | 168893 | 453534 | 109966316 |
| Polyneuropathy | 15.13 | 9.81 | 16 | 169433 | 31996 | 110387854 |
| Emotional distress | 15.07 | 9.81 | 119 | 169330 | 44728 | 110375122 |
| Presyncope | 14.96 | 9.81 | 127 | 169322 | 48760 | 110371090 |
| Abdominal mass | 14.90 | 9.81 | 27 | 169422 | 4914 | 110414936 |
| Epiglottic oedema | 14.89 | 9.81 | 9 | 169440 | 437 | 110419413 |
| Dysmetropsia | 14.77 | 9.81 | 6 | 169443 | 121 | 110419729 |
| Decreased immune responsiveness | 14.71 | 9.81 | 40 | 169409 | 9566 | 110410284 |
| Multiple sclerosis | 14.70 | 9.81 | 78 | 169371 | 25620 | 110394230 |
| Sleep disorder | 14.66 | 9.81 | 215 | 169234 | 198429 | 110221421 |
| Oral pain | 14.65 | 9.81 | 103 | 169346 | 37341 | 110382509 |
| Anxiety | 14.48 | 9.81 | 657 | 168792 | 344421 | 110075429 |
| Hypoacusis | 14.48 | 9.81 | 98 | 169351 | 35093 | 110384757 |
| Breath sounds abnormal | 14.46 | 9.81 | 77 | 169372 | 25327 | 110394523 |
| Stress | 14.32 | 9.81 | 234 | 169215 | 105114 | 110314736 |
| Spinal compression fracture | 14.29 | 9.81 | 61 | 169388 | 18331 | 110401519 |
| Aspergillus infection | 14.26 | 9.81 | 11 | 169438 | 25605 | 110394245 |
| Dysstasia | 14.26 | 9.81 | 93 | 169356 | 32893 | 110386957 |
| Anal incontinence | 14.20 | 9.81 | 69 | 169380 | 21895 | 110397955 |
| Rubber sensitivity | 14.16 | 9.81 | 18 | 169431 | 2400 | 110417450 |
| Joint dislocation | 14.12 | 9.81 | 19 | 169430 | 34171 | 110385679 |
| Transaminases increased | 14.12 | 9.81 | 154 | 169295 | 63236 | 110356614 |
| Agranulocytosis | 14.06 | 9.81 | 48 | 169401 | 61712 | 110358138 |
| Hyperaesthesia | 13.98 | 9.81 | 52 | 169397 | 14675 | 110405175 |
| Aortic aneurysm | 13.95 | 9.81 | 40 | 169409 | 9864 | 110409986 |
| Hepatotoxicity | 13.94 | 9.81 | 50 | 169399 | 63350 | 110356500 |
| Renal impairment | 13.89 | 9.81 | 204 | 169245 | 188241 | 110231609 |
| Rib fracture | 13.87 | 9.81 | 94 | 169355 | 33676 | 110386174 |
| Contusion | 13.81 | 9.81 | 263 | 169186 | 233098 | 110186752 |
| Adverse reaction | 13.75 | 9.81 | 15 | 169434 | 29579 | 110390271 |
| Therapeutic response shortened | 13.74 | 9.81 | 15 | 169434 | 29568 | 110390282 |
| Wrong technique in product usage process | 13.73 | 9.81 | 78 | 169371 | 87270 | 110332580 |
| Pleurothotonus | 13.70 | 9.81 | 18 | 169431 | 2480 | 110417370 |
| Infusion site reaction | 13.65 | 9.81 | 5 | 169444 | 17677 | 110402173 |
| Exposure during pregnancy | 13.50 | 9.81 | 178 | 169271 | 167246 | 110252604 |
| Blood glucose increased | 13.38 | 9.81 | 281 | 169168 | 132215 | 110287635 |
| Sinus tachycardia | 13.31 | 9.81 | 115 | 169334 | 44378 | 110375472 |
| Heparin-induced thrombocytopenia | 13.15 | 9.81 | 43 | 169406 | 11381 | 110408469 |
| Intentional product misuse | 13.14 | 9.81 | 281 | 169168 | 132623 | 110287227 |
| Ear pain | 13.06 | 9.81 | 40 | 169409 | 53186 | 110366664 |
| Gamma-glutamyltransferase increased | 13.06 | 9.81 | 49 | 169400 | 61260 | 110358590 |
| Blood sodium decreased | 13.05 | 9.81 | 102 | 169347 | 38217 | 110381633 |
| Pneumococcal infection | 13.03 | 9.81 | 15 | 169434 | 1804 | 110418046 |
| Urosepsis | 12.97 | 9.81 | 86 | 169363 | 30589 | 110389261 |
| Bacteroides infection | 12.96 | 9.81 | 19 | 169430 | 2900 | 110416950 |
| Oral pustule | 12.95 | 9.81 | 7 | 169442 | 274 | 110419576 |
| Device expulsion | 12.93 | 9.81 | 17 | 169432 | 30874 | 110388976 |
| Blood phosphorus decreased | 12.84 | 9.81 | 33 | 169416 | 7632 | 110412218 |
| Posterior reversible encephalopathy syndrome | 12.82 | 9.81 | 20 | 169429 | 33841 | 110386009 |
| Urinary tract obstruction | 12.80 | 9.81 | 26 | 169423 | 5151 | 110414699 |
| Drug effective for unapproved indication | 12.77 | 9.81 | 3 | 169446 | 14164 | 110405686 |
| Ankylosing spondylitis | 12.77 | 9.81 | 4 | 169445 | 15608 | 110404242 |
| Pulmonary hypertension | 12.69 | 9.81 | 135 | 169314 | 55085 | 110364765 |
| Blood loss anaemia | 12.66 | 9.81 | 58 | 169391 | 17967 | 110401883 |
| Lower gastrointestinal haemorrhage | 12.62 | 9.81 | 59 | 169390 | 18427 | 110401423 |
| Catheter site bruise | 12.57 | 9.81 | 9 | 169440 | 582 | 110419268 |
| Shock haemorrhagic | 12.46 | 9.81 | 14 | 169435 | 27233 | 110392617 |
| Duodenal stenosis | 12.44 | 9.81 | 11 | 169438 | 966 | 110418884 |
| Hyperglycaemia | 12.32 | 9.81 | 191 | 169258 | 84899 | 110334951 |
| Airway burns | 12.30 | 9.81 | 3 | 169446 | 9 | 110419841 |
| Non-cardiac chest pain | 12.30 | 9.81 | 39 | 169410 | 10159 | 110409691 |
| Noninfectious peritonitis | 12.29 | 9.81 | 7 | 169442 | 304 | 110419546 |
| Blood bilirubin decreased | 12.29 | 9.81 | 13 | 169436 | 1424 | 110418426 |
| Oesophageal injury | 12.25 | 9.81 | 7 | 169442 | 306 | 110419544 |
| Myotonic dystrophy | 12.18 | 9.81 | 6 | 169443 | 193 | 110419657 |
| Hypovitaminosis | 12.12 | 9.81 | 13 | 169436 | 1447 | 110418403 |
| Non-small cell lung cancer | 12.11 | 9.81 | 33 | 169416 | 7902 | 110411948 |
| Pneumonectomy | 12.08 | 9.81 | 5 | 169444 | 106 | 110419744 |
| Prescribed underdose | 12.06 | 9.81 | 55 | 169394 | 65119 | 110354731 |
| Rhabdomyolysis | 12.04 | 9.81 | 122 | 169327 | 120279 | 110299571 |
| Pustular psoriasis | 12.03 | 9.81 | 3 | 169446 | 13602 | 110406248 |
| Paratracheal lymphadenopathy | 11.93 | 9.81 | 6 | 169443 | 202 | 110419648 |
| Bronchopulmonary aspergillosis | 11.93 | 9.81 | 17 | 169432 | 29846 | 110390004 |
| Intentional underdose | 11.89 | 9.81 | 17 | 169432 | 2535 | 110417315 |
| Body temperature fluctuation | 11.87 | 9.81 | 21 | 169428 | 3752 | 110416098 |
| Pathological fracture | 11.85 | 9.81 | 43 | 169406 | 11989 | 110407861 |
| Osteonecrosis of jaw | 11.85 | 9.81 | 36 | 169413 | 47981 | 110371869 |
| Asterixis | 11.83 | 9.81 | 19 | 169430 | 3139 | 110416711 |
| Clostridium difficile infection | 11.78 | 9.81 | 127 | 169322 | 52002 | 110367848 |
| Injection site warmth | 11.72 | 9.81 | 6 | 169443 | 17399 | 110402451 |
| Inguinal hernia | 11.66 | 9.81 | 32 | 169417 | 7693 | 110412157 |
| Malignant neoplasm of thorax | 11.64 | 9.81 | 3 | 169446 | 12 | 110419838 |
| Nasal discharge discolouration | 11.64 | 9.81 | 19 | 169430 | 3182 | 110416668 |
| Multiple-drug resistance | 11.55 | 9.81 | 3 | 169446 | 13232 | 110406618 |
| Systemic inflammatory response syndrome | 11.51 | 9.81 | 45 | 169404 | 12998 | 110406852 |
| Pericardial effusion | 11.39 | 9.81 | 136 | 169313 | 57081 | 110362769 |
| Drug dose omission by device | 11.38 | 9.81 | 4 | 169445 | 14512 | 110405338 |
| Faeces discoloured | 11.36 | 9.81 | 90 | 169359 | 33858 | 110385992 |
| Multiple injuries | 11.22 | 9.81 | 20 | 169429 | 3594 | 110416256 |
| Nasal polyps | 11.22 | 9.81 | 45 | 169404 | 13155 | 110406695 |
| Mean platelet volume increased | 11.11 | 9.81 | 13 | 169436 | 1591 | 110418259 |
| Exposure to toxic agent | 11.06 | 9.81 | 3 | 169446 | 12855 | 110406995 |
| Catheter site pain | 11.05 | 9.81 | 28 | 169421 | 6418 | 110413432 |
| Oesophageal ulcer | 11.05 | 9.81 | 32 | 169417 | 7932 | 110411918 |
| Skin laceration | 11.03 | 9.81 | 89 | 169360 | 33664 | 110386186 |
| Cognitive disorder | 11.03 | 9.81 | 192 | 169257 | 87319 | 110332531 |
| Chronic sinusitis | 11.01 | 9.81 | 71 | 169378 | 25013 | 110394837 |
| Onychoclasis | 10.95 | 9.81 | 30 | 169419 | 7207 | 110412643 |
| Lymphocyte count decreased | 10.93 | 9.81 | 135 | 169314 | 57108 | 110362742 |
| Phlebosclerosis | 10.93 | 9.81 | 5 | 169444 | 136 | 110419714 |
| Circulatory collapse | 10.77 | 9.81 | 32 | 169417 | 42961 | 110376889 |
| Injection site rash | 10.74 | 9.81 | 12 | 169437 | 23407 | 110396443 |
| Nephropathy | 10.72 | 9.81 | 45 | 169404 | 13422 | 110406428 |
| Nodule | 10.65 | 9.81 | 86 | 169363 | 32545 | 110387305 |
| Coma | 10.64 | 9.81 | 246 | 169203 | 117623 | 110302227 |
| Gastrointestinal arteriovenous malformation | 10.59 | 9.81 | 10 | 169439 | 955 | 110418895 |
| Transient ischaemic attack | 10.59 | 9.81 | 147 | 169302 | 63835 | 110356015 |
| Perirectal abscess | 10.59 | 9.81 | 15 | 169434 | 2219 | 110417631 |
| Spleen atrophy | 10.58 | 9.81 | 4 | 169445 | 66 | 110419784 |
| Essential thrombocythaemia | 10.54 | 9.81 | 7 | 169442 | 401 | 110419449 |
| Epstein-Barr virus infection | 10.49 | 9.81 | 8 | 169441 | 18730 | 110401120 |
| Red cell distribution width increased | 10.46 | 9.81 | 54 | 169395 | 17548 | 110402302 |
| Pneumothorax | 10.45 | 9.81 | 91 | 169358 | 35194 | 110384656 |
| Cholecystitis chronic | 10.26 | 9.81 | 35 | 169414 | 9465 | 110410385 |
| Psychotic symptom | 10.26 | 9.81 | 20 | 169429 | 3847 | 110416003 |
| Blood chloride decreased | 10.22 | 9.81 | 34 | 169415 | 9081 | 110410769 |
| Diabetic wound | 10.21 | 9.81 | 4 | 169445 | 73 | 110419777 |
| Urinary retention postoperative | 10.20 | 9.81 | 6 | 169443 | 277 | 110419573 |
| Spinal cord compression | 10.15 | 9.81 | 30 | 169419 | 7522 | 110412328 |
| Osteoarthritis | 10.14 | 9.81 | 208 | 169241 | 182415 | 110237435 |
| Cervical vertebral fracture | 10.07 | 9.81 | 22 | 169427 | 4583 | 110415267 |
| Hypertonia | 10.00 | 9.81 | 32 | 169417 | 8374 | 110411476 |
| Light chain analysis increased | 9.98 | 9.81 | 15 | 169434 | 2340 | 110417510 |
| Conjunctival pigmentation | 9.92 | 9.81 | 4 | 169445 | 79 | 110419771 |
| Convulsive threshold lowered | 9.91 | 9.81 | 10 | 169439 | 1036 | 110418814 |
| Premature delivery | 9.88 | 9.81 | 20 | 169429 | 30612 | 110389238 |
| Inappropriate schedule of product administration | 9.86 | 9.81 | 237 | 169212 | 203400 | 110216450 |
| Mitochondrial myopathy | 9.86 | 9.81 | 7 | 169442 | 447 | 110419403 |
| Multiple sclerosis relapse | 9.82 | 9.81 | 119 | 169330 | 50121 | 110369729 |
FDA Adverse Event Reporting System (Pediatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hypovolaemic shock | 29.29 | 28.84 | 17 | 342 | 372 | 113222 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A06AA02 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Softeners, emollients |
| ATC | A06AG10 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Enemas |
| MeSH PA | D013501 | Surface-Active Agents |
| CHEBI has role | CHEBI:50503 | laxative |
| CHEBI has role | CHEBI:55324 | gastrointestinal drug |
| CHEBI has role | CHEBI:75835 | anti-anaemic agent |
Related Drugs by ATC class:
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Constipation | indication | 14760008 | DOID:2089 |
| Megaloblastic anemia due to folate deficiency | indication | 85649008 | DOID:14026 |
| Iron deficiency anemia | indication | 87522002 | |
| Pregnancy, function | indication | 289908002 | |
| Breastfeeding (mother) | indication | 413712001 | |
| Incomplete passage of stool | off-label use | 249515001 | |
| Prevention of Fetal Neural Tube Defects during Pregnancy | off-label use | ||
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Primary hyperoxaluria | contraindication | 17901006 | DOID:2977 |
| Gastroenteritis | contraindication | 25374005 | DOID:2326 |
| Hemosiderosis | contraindication | 39011001 | DOID:12119 |
| Hypokalemia | contraindication | 43339004 | |
| Bleeding hemorrhoids | contraindication | 51551000 | |
| Gastrectomy | contraindication | 53442002 | |
| Leber's optic atrophy | contraindication | 58610003 | DOID:705 |
| Hemolytic anemia | contraindication | 61261009 | DOID:583 |
| Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
| Incontinence of feces | contraindication | 72042002 | |
| Appendicitis | contraindication | 74400008 | DOID:8337 |
| Atrophic gastritis | contraindication | 84568007 | DOID:8929 |
| Disorder of mucous membrane | contraindication | 95351003 | |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Hb SS disease | contraindication | 127040003 | DOID:10923 |
| Urinary incontinence | contraindication | 165232002 | |
| Diverticular disease | contraindication | 397881000 | |
| Hemochromatosis | contraindication | 399187006 | DOID:2352 |
| Repeated Blood Transfusions | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.0 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4019731 | VUID |
| N0000179792 | NUI |
| D03885 | KEGG_DRUG |
| 577-11-7 | SECONDARY_CAS_RN |
| 128-49-4 | SECONDARY_CAS_RN |
| 71722 | RXNORM |
| 4017673 | VANDF |
| 4019248 | VANDF |
| 4019731 | VANDF |
| C0243237 | UMLSCUI |
| CHEBI:4674 | CHEBI |
| CHEMBL1905872 | ChEMBL_ID |
| CHEMBL1477036 | ChEMBL_ID |
| CHEMBL2106608 | ChEMBL_ID |
| 531 | INN_ID |
| F05Q2T2JA0 | UNII |
| 23673837 | PUBCHEM_CID |
| DB11089 | DRUGBANK_ID |
| 29340 | MMSL |
| 4627 | MMSL |
| 4629 | MMSL |
| 6142 | MMSL |
| 6143 | MMSL |
| NOCODE | MMSL |
| d01021 | MMSL |
| 001180 | NDDF |
| 001181 | NDDF |
| 001183 | NDDF |
| 116528004 | SNOMEDCT_US |
| 387088007 | SNOMEDCT_US |
| 418528006 | SNOMEDCT_US |
| 418700002 | SNOMEDCT_US |
| D004143 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| good sense stool softener | HUMAN OTC DRUG LABEL | 1 | 0113-0486 | CAPSULE, LIQUID FILLED | 100 mg | ORAL | OTC Monograph Drug | 15 sections |
| Docusate Sodium | HUMAN OTC DRUG LABEL | 1 | 0121-0935 | LIQUID | 50 mg | ORAL | OTC Monograph Drug | 15 sections |
| Docusate Sodium | HUMAN OTC DRUG LABEL | 1 | 0121-1870 | LIQUID | 100 mg | ORAL | OTC Monograph Drug | 15 sections |
| Pedia-Lax | HUMAN OTC DRUG LABEL | 1 | 0132-0113 | LIQUID | 50 mg | ORAL | OTC Monograph Drug | 13 sections |
| Fleet | HUMAN OTC DRUG LABEL | 1 | 0132-0402 | CAPSULE, LIQUID FILLED | 100 mg | ORAL | OTC Monograph Drug | 14 sections |
| Ferralet 90 | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0178-0089 | TABLET, FILM COATED | 50 mg | ORAL | unapproved drug other | 17 sections |
| CitraNatal Harmony | HUMAN PRESCRIPTION DRUG LABEL | 8 | 0178-0798 | CAPSULE, GELATIN COATED | 50 mg | ORAL | UNAPPROVED DRUG OTHER | 11 sections |
| CitraNatal Harmony | HUMAN PRESCRIPTION DRUG LABEL | 8 | 0178-0799 | CAPSULE, GELATIN COATED | 50 mg | ORAL | Unapproved drug other | 11 sections |
| CitraNatal Harmony | HUMAN PRESCRIPTION DRUG LABEL | 8 | 0178-0812 | CAPSULE, GELATIN COATED | 50 mg | ORAL | Unapproved drug other | 11 sections |
| CitraNatal 90 DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0178-0821 | TABLET | 50 mg | ORAL | unapproved drug other | 11 sections |
| CitraNatal 90 DHA | HUMAN OTC DRUG LABEL | 14 | 0178-0829 | TABLET | 50 mg | ORAL | Unapproved drug other | 11 sections |
| CitraNatal Rx | HUMAN PRESCRIPTION DRUG LABEL | 14 | 0178-0859 | TABLET | 50 mg | ORAL | Unapproved drug other | 9 sections |
| CitraNatal DHA | HUMAN OTC DRUG LABEL | 14 | 0178-0898 | TABLET | 50 mg | ORAL | Unapproved drug other | 11 sections |
| Phillips Stool SoftenerBulk Docusate | HUMAN OTC DRUG LABEL | 1 | 0280-1012 | CAPSULE, LIQUID FILLED | 100 mg | ORAL | OTC Monograph Drug | 15 sections |
| Stool Softener LaxativePlus Stimulant | HUMAN OTC DRUG LABEL | 2 | 0363-0827 | TABLET | 50 mg | ORAL | OTC Monograph Drug | 14 sections |
| Stool Softener | HUMAN OTC DRUG LABEL | 1 | 0363-0868 | CAPSULE, LIQUID FILLED | 240 mg | ORAL | OTC Monograph Drug | 14 sections |
| Senna S | HUMAN OTC DRUG LABEL | 2 | 0363-0883 | TABLET | 50 mg | ORAL | OTC Monograph Drug | 14 sections |
| Gentle Stool Softener | HUMAN OTC DRUG LABEL | 1 | 0363-1172 | CAPSULE, LIQUID FILLED | 100 mg | ORAL | OTC Monograph Drug | 14 sections |
| Gentle Stool Softener | HUMAN OTC DRUG LABEL | 1 | 0363-1172 | CAPSULE, LIQUID FILLED | 100 mg | ORAL | OTC Monograph Drug | 14 sections |
| Senna S | HUMAN OTC DRUG LABEL | 2 | 0363-1173 | CAPSULE, LIQUID FILLED | 50 mg | ORAL | OTC Monograph Drug | 14 sections |
| Senna S | HUMAN OTC DRUG LABEL | 2 | 0363-1173 | CAPSULE, LIQUID FILLED | 50 mg | ORAL | OTC Monograph Drug | 14 sections |
| Gentle Stool Softener | HUMAN OTC DRUG LABEL | 1 | 0363-1179 | CAPSULE, LIQUID FILLED | 100 mg | ORAL | OTC Monograph Drug | 14 sections |
| Gentle Stool Softener | HUMAN OTC DRUG LABEL | 1 | 0363-1179 | CAPSULE, LIQUID FILLED | 100 mg | ORAL | OTC Monograph Drug | 14 sections |
| Stool Softener | HUMAN OTC DRUG LABEL | 1 | 0363-2570 | CAPSULE, LIQUID FILLED | 240 mg | ORAL | OTC Monograph Drug | 14 sections |
| Stool Softener Laxative | HUMAN OTC DRUG LABEL | 1 | 0363-4100 | CAPSULE, LIQUID FILLED | 100 mg | ORAL | OTC Monograph Drug | 14 sections |
| Stool Softener Laxative | HUMAN OTC DRUG LABEL | 1 | 0363-4202 | CAPSULE, LIQUID FILLED | 100 mg | ORAL | OTC Monograph Drug | 14 sections |
| Senna-S | HUMAN OTC DRUG LABEL | 2 | 0363-6683 | CAPSULE, LIQUID FILLED | 50 mg | ORAL | OTC Monograph Drug | 13 sections |
| Stool Softener Laxative | HUMAN OTC DRUG LABEL | 1 | 0363-7111 | CAPSULE, LIQUID FILLED | 100 mg | ORAL | OTC Monograph Drug | 14 sections |
| Walgreens Stool Softener Fruit Punch | HUMAN OTC DRUG LABEL | 1 | 0363-7140 | LIQUID | 50 mg | ORAL | OTC Monograph Drug | 11 sections |
| Stool Softener Laxative | HUMAN OTC DRUG LABEL | 1 | 0363-8530 | CAPSULE, LIQUID FILLED | 100 mg | ORAL | OTC Monograph Drug | 14 sections |