glycerol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1316	56-81-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: glycerol glycerin glycerine propane-1,2,3-triol 1,2,3-triglycerol glycyl alcohol	A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent. Molecular weight: 92.09 Formula: C3H8O3 CLOGP: -1.54 LIPINSKI: 0 HAC: 3 HDO: 3 TPSA: 60.69 ALOGS: 1.10 ROTB: 2

Molecule

Description

Molfile Inchi Smiles

Synonyms:

glycerol
glycerin
glycerine
propane-1,2,3-triol
1,2,3-triglycerol
glycyl alcohol

A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.

Molecular weight: 92.09
Formula: C3H8O3
CLOGP: -1.54
LIPINSKI: 0
HAC: 3
HDO: 3
TPSA: 60.69
ALOGS: 1.10
ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
May 6, 1982	FDA	B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	217.18	27.46	42	381	3700	2353962
Coma	180.18	27.46	42	381	9014	2348648
Gastrooesophageal reflux disease	174.68	27.46	41	382	9054	2348608
Eye irritation	158.42	27.46	32	391	3480	2354182
Somnolence	144.88	27.46	43	380	23442	2334220
Drug hypersensitivity	94.04	27.46	37	386	46606	2311056
Drug ineffective	80.70	27.46	42	381	101582	2256080
Eye discharge	50.96	27.46	10	413	913	2356749
Pruritus	46.07	27.46	22	401	43318	2314344
Foreign body sensation in eyes	44.89	27.46	8	415	432	2357230
Eye pain	43.45	27.46	12	411	4879	2352783
Ocular hyperaemia	40.91	27.46	11	412	4045	2353617
Eyelid oedema	40.55	27.46	10	413	2616	2355046
Menstruation delayed	39.27	27.46	7	416	378	2357284
Vision blurred	34.08	27.46	13	410	14655	2343007
Foetal alcohol syndrome	33.73	27.46	4	419	9	2357653
Weight decreased	28.82	27.46	14	409	28357	2329305

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	50.41	36.27	18	252	16294	1730217
Cerebrovascular accident	48.81	36.27	18	252	17848	1728663
Diabetic foot infection	46.20	36.27	7	263	129	1746382
Oedema peripheral	43.65	36.27	16	254	15534	1730977
Finger amputation	41.56	36.27	6	264	78	1746433
Ascites	41.33	36.27	12	258	5574	1740937
Drug reaction with eosinophilia and systemic symptoms	37.98	36.27	11	259	5059	1741452

Pharmacologic Action:

Source	Code	Description
ATC	A06AG04	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Enemas
ATC	A06AX01	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Other drugs for constipation
CHEBI has role	CHEBI:46787	solvent
CHEBI has role	CHEBI:27780	detergent
FDA EPC	N0000185370	Non-Standardized Chemical Allergen
FDA PE	N0000175629	Increased Histamine Release
FDA PE	N0000184306	Cell-mediated Immunity
FDA PE	N0000185001	Increased IgG Production
FDA CS	M0000728	Allergens
FDA CS	M0009417	Glycerol
MeSH PA	D003451	Cryoprotective Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D012997	Solvents

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Constipation	indication	14760008	DOID:2089

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D005990	MESH_DESCRIPTOR_UI
4017411	VUID
N0000145799	NUI
C0017861	UMLSCUI
D00028	KEGG_DRUG
80582002	SNOMEDCT_US
404833002	SNOMEDCT_US
602	MMSL
4792	MMSL
d00652	MMSL
4017411	VANDF
52080	MMSL
108842	MMSL
4910	RXNORM
002240	NDDF
001176	NDDF
002469	NDDF
001893	NDDF
004085	NDDF
002291	NDDF
753	PUBCHEM_CID
CHEBI:17754	CHEBI
CHEMBL692	ChEMBL_ID
PDC6A3C0OX	UNII
444	INN_ID
GOL	PDB_CHEM_ID
DB09462	DRUGBANK_ID
5195	IUPHAR_LIGAND_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
REFRESH OPTIVE	HUMAN OTC DRUG LABEL	1	0023-3240	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	8 sections
Refresh Optive	HUMAN OTC DRUG LABEL	1	0023-3416	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	9 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	2	0023-4307	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	2	0023-4491	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	9 sections
Refresh Repair	HUMAN OTC DRUG LABEL	1	0023-4607	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	8 sections
REFRESH OPTIVE Drops	HUMAN OTC DRUG LABEL	1	0023-5459	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	9 sections
REFRESH OPTIVE Mega-3	HUMAN OTC DRUG LABEL	2	0023-5773	SOLUTION/ DROPS	10 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	8 sections
Refresh Repair Preservative-free	HUMAN OTC DRUG LABEL	1	0023-6465	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	8 sections
Refresh Relieva	HUMAN OTC DRUG LABEL	1	0023-6630	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	8 sections
Refresh Relieva Preservative Free	HUMAN OTC DRUG LABEL	1	0023-6634	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	8 sections
Endura	HUMAN PRESCRIPTION DRUG LABEL	2	0023-9235	SOLUTION/ DROPS	1 g	OPHTHALMIC	EXPORT ONLY	1 sections
GenTeal Tears (Moderate)	HUMAN OTC DRUG LABEL	1	0065-0426	SOLUTION/ DROPS	2 mg	OPHTHALMIC	OTC monograph final	12 sections
Good Sense Hemorrhoidal	HUMAN OTC DRUG LABEL	3	0113-0944	CREAM	14.40 g	TOPICAL	OTC monograph final	9 sections
Fleet	HUMAN OTC DRUG LABEL	1	0132-0079	SUPPOSITORY	2 g	RECTAL	OTC monograph not final	9 sections
Fleet	HUMAN OTC DRUG LABEL	1	0132-0185	LIQUID	5.40 g	RECTAL	OTC monograph not final	11 sections
Pedia-Lax	HUMAN OTC DRUG LABEL	1	0132-0190	LIQUID	2.80 g	RECTAL	OTC monograph not final	10 sections
Pedia-Lax	HUMAN OTC DRUG LABEL	1	0132-0195	LIQUID	2.80 g	RECTAL	OTC MONOGRAPH NOT FINAL	9 sections
ProcalAmine	HUMAN PRESCRIPTION DRUG LABEL	22	0264-1915	INJECTION	3 g	INTRAVENOUS	NDA	13 sections
Chloraseptic Sore Throat Max	HUMAN OTC DRUG LABEL	2	0295-1749	SPRAY	33 mg	ORAL	OTC monograph not final	8 sections
Walgreens Children Glycerin	HUMAN OTC DRUG LABEL	1	0363-0440	SUPPOSITORY	83 g	RECTAL	OTC monograph not final	12 sections
Walgreens Adult Glycerin	HUMAN OTC DRUG LABEL	1	0363-0445	SUPPOSITORY	83 g	RECTAL	OTC monograph not final	13 sections
Hemorrhoidal Cream	HUMAN OTC DRUG LABEL	3	0363-0641	CREAM	14.40 g	TOPICAL	OTC monograph not final	15 sections
hemorrhoidal	HUMAN OTC DRUG LABEL	3	0363-0944	CREAM	14.40 g	TOPICAL	OTC monograph final	9 sections
Walgreens Multi-Symptom Relief Eye Drops	HUMAN OTC DRUG LABEL	4	0363-1462	SOLUTION/ DROPS	0.20 g	OPHTHALMIC	OTC monograph final	8 sections
WALGREENS MAXIMUM REDNESS RELIEF	HUMAN OTC DRUG LABEL	2	0363-1465	SOLUTION	0.00 mg	OPHTHALMIC	OTC monograph final	12 sections
Walgreens Maximum Strength Hemorrhoidal	HUMAN OTC DRUG LABEL	3	0363-1760	CREAM	0.14 mg	TOPICAL	OTC monograph final	12 sections
Walgreens Lubricant Eye	HUMAN OTC DRUG LABEL	1	0363-1791	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC monograph final	9 sections
Walgreens Lubricant Eye	HUMAN OTC DRUG LABEL	1	0363-1792	SOLUTION/ DROPS	9 mg	OPHTHALMIC	OTC monograph final	9 sections
Walgreens Eye Drops Maximum Redness Relief 15mL	HUMAN OTC DRUG LABEL	2	0363-4546	LIQUID	0.50 g	OPHTHALMIC	OTC monograph final	8 sections
Walgreens Redness Relief Eye Drops 15mL	HUMAN OTC DRUG LABEL	2	0363-4548	LIQUID	0.25 g	OPHTHALMIC	OTC monograph final	9 sections