ascorbic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4072	50-81-7

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: vitamin c L-Ascorbic acid ascorbic acid ascorbic acid (vit C) sodium ascorbate calcium ascorbate ascorbic acid, monosodium salt

A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. NIH COVID-19 Treatment Guidelines Panel states that there are insufficient data to recommend either for or against use of ascorbic acid for the treatment of COVID-19 in critically or noncritically ill patients. Molecular weight: 176.12 Formula: C6H8O6 CLOGP: -1.76 LIPINSKI: 0 HAC: 6 HDO: 4 TPSA: 107.22 ALOGS: 0.14 ROTB: 2

Drug dosage:

Dose	Unit	Route
0.20	g	O
0.20	g	P
0.25	g	V

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	0	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	333 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	25 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	567.77 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	99 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.35 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1.05 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.26 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	11.40 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	884.30	9.88	71	368353	145849	46171789
Rheumatoid arthritis	825.58	9.88	3915	364509	236300	46081338
Pemphigus	710.56	9.88	1279	367145	43995	46273643
Systemic lupus erythematosus	586.07	9.88	1467	366957	63713	46253925
Toxicity to various agents	579.44	9.88	492	367932	211274	46106364
Glossodynia	476.06	9.88	1070	367354	43303	46274335
Pain	368.51	9.88	5537	362887	471411	45846227
Death	359.14	9.88	1398	367026	334150	45983488
Drug abuse	354.61	9.88	42	368382	63366	46254272
Hand deformity	345.72	9.88	811	367613	33763	46283875
Drug interaction	338.30	9.88	683	367741	202411	46115227
Arthropathy	303.45	9.88	1399	367025	83301	46234337
Alopecia	303.12	9.88	2257	366167	160157	46157481
Joint swelling	296.55	9.88	2284	366140	163789	46153849
Abdominal discomfort	295.43	9.88	2124	366300	149041	46168597
Maternal exposure during pregnancy	295.28	9.88	1592	366832	100957	46216681
Intentional overdose	287.92	9.88	78	368346	64866	46252772
Infusion related reaction	248.54	9.88	1506	366918	99702	46217936
Arthralgia	223.51	9.88	4078	364346	360525	45957113
Wound	211.68	9.88	781	367643	42021	46275617
Suicide attempt	207.60	9.88	87	368337	54949	46262689
Overdose	204.18	9.88	305	368119	101674	46215964
Cardiac arrest	180.35	9.88	271	368153	90128	46227510
Nasopharyngitis	180.09	9.88	1933	366491	152065	46165573
Exposure during pregnancy	174.26	9.88	1454	366970	106758	46210880
Drug hypersensitivity	168.41	9.88	1179	367245	242646	46074992
Contraindicated product administered	165.12	9.88	1139	367285	78808	46238830
Febrile neutropenia	161.84	9.88	313	368111	94314	46223324
Acute kidney injury	159.20	9.88	1148	367276	234707	46082931
Anti-cyclic citrullinated peptide antibody positive	157.54	9.88	417	368007	18728	46298910
Synovitis	155.71	9.88	918	367506	60157	46257481
Pericarditis	141.20	9.88	463	367961	23464	46294174
Hip arthroplasty	140.49	9.88	386	368038	17726	46299912
Swelling	133.66	9.88	1537	366887	122974	46194664
Rheumatoid factor positive	130.82	9.88	407	368017	20054	46297584
Knee arthroplasty	123.06	9.88	439	367985	23226	46294412
Cardiac failure	121.19	9.88	283	368141	79665	46237973
Lactic acidosis	119.45	9.88	59	368365	33850	46283788
Sinusitis	115.22	9.88	1546	366878	128222	46189416
Device expulsion	113.12	9.88	38	368386	27504	46290134
Red blood cell sedimentation rate abnormal	110.99	9.88	296	368128	13353	46304285
Depressed level of consciousness	107.62	9.88	130	368294	47439	46270199
Injection site erythema	107.21	9.88	976	367448	73451	46244187
Sickle cell anaemia with crisis	104.85	9.88	143	368281	3849	46313789
Cardio-respiratory arrest	101.50	9.88	199	368225	59670	46257968
Discomfort	100.54	9.88	672	367752	45998	46271640
Neutropenia	99.44	9.88	691	367733	142513	46175125
Immunodeficiency	99.36	9.88	277	368147	12829	46304809
Drug reaction with eosinophilia and systemic symptoms	98.78	9.88	55	368369	29493	46288145
C-reactive protein abnormal	98.41	9.88	380	368044	20890	46296748
Respiratory arrest	97.99	9.88	74	368350	33742	46283896
Sopor	97.44	9.88	19	368405	19809	46297829
Pregnancy	94.69	9.88	445	367979	26692	46290946
Malignant neoplasm progression	94.30	9.88	235	368189	64691	46252947
Lower respiratory tract infection	93.87	9.88	750	367674	54339	46263299
Product use issue	93.45	9.88	1150	367274	93494	46224144
Intentional self-injury	93.07	9.88	37	368387	24129	46293509
Electrocardiogram QT prolonged	91.94	9.88	165	368259	51160	46266478
Fatigue	90.17	9.88	5757	362667	602940	45714698
Musculoskeletal stiffness	89.24	9.88	1173	367251	96820	46220818
Arthritis	89.09	9.88	968	367456	76348	46241290
Confusional state	86.51	9.88	825	367599	159067	46158571
Rhabdomyolysis	86.12	9.88	123	368301	41786	46275852
Injection site pain	85.97	9.88	1254	367170	105898	46211740
Bradycardia	84.31	9.88	256	368168	66042	46251596
Renal failure	83.92	9.88	538	367886	113056	46204582
Osteoarthritis	83.62	9.88	802	367622	61223	46256415
Hyponatraemia	81.63	9.88	467	367957	100865	46216773
Injection site pruritus	77.78	9.88	559	367865	39184	46278454
Disease progression	75.58	9.88	417	368007	90883	46226755
Blood pressure fluctuation	74.58	9.88	453	367971	29995	46287643
Femur fracture	72.76	9.88	521	367903	36476	46281162
Injection site reaction	72.76	9.88	635	367789	47214	46270424
Dyspnoea	72.44	9.88	3329	365095	512219	45805419
Injection site swelling	70.32	9.88	552	367872	39775	46277863
Bursitis	69.68	9.88	326	368098	19516	46298122
Abortion spontaneous	68.34	9.88	583	367841	43063	46274575
Psoriatic arthropathy	67.93	9.88	506	367918	35873	46281765
Temperature regulation disorder	67.41	9.88	106	368318	3254	46314384
Agitation	66.92	9.88	219	368205	55196	46262442
Hypoglycaemia	66.88	9.88	213	368211	54136	46263502
Hepatocellular injury	66.43	9.88	81	368343	29441	46288197
Drug dependence	65.15	9.88	38	368386	19863	46297775
Hepatic enzyme increased	64.73	9.88	955	367469	80832	46236806
Hypotension	63.89	9.88	1374	367050	231215	46086423
Basal cell carcinoma	63.64	9.88	325	368099	20162	46297476
Tachycardia	63.22	9.88	493	367931	99129	46218509
Peripheral swelling	62.27	9.88	1661	366763	156410	46161228
Poisoning	61.64	9.88	17	368407	13977	46303661
Cholestasis	61.35	9.88	73	368351	26820	46290818
Metabolic acidosis	60.59	9.88	135	368289	38645	46278993
Cytomegalovirus infection	60.32	9.88	34	368390	18110	46299528
Product quality issue	59.11	9.88	120	368304	35528	46282110
Disability assessment scale score increased	57.18	9.88	79	368345	2153	46315485
Serotonin syndrome	57.13	9.88	64	368360	24156	46293482
Hepatic failure	56.69	9.88	111	368313	33305	46284333
General physical health deterioration	56.52	9.88	612	367812	115157	46202481
Duodenal ulcer perforation	56.09	9.88	171	368253	8331	46309307
Osteoporosis	55.67	9.88	527	367897	40081	46277557
Joint effusion	55.24	9.88	214	368210	11781	46305857
Delirium	54.63	9.88	134	368290	37094	46280544
Renal impairment	54.52	9.88	353	368071	74019	46243619
Drug resistance	52.95	9.88	36	368388	17332	46300306
Helicobacter infection	52.12	9.88	207	368217	11529	46306109
Impaired healing	51.95	9.88	480	367944	36263	46281375
Drug withdrawal syndrome	51.81	9.88	85	368339	27299	46290339
Pulmonary arterial hypertension	51.41	9.88	78	368346	25850	46291788
Multiple organ dysfunction syndrome	50.97	9.88	222	368202	51488	46266150
Product use in unapproved indication	50.40	9.88	462	367962	89811	46227827
Therapeutic product effect decreased	48.94	9.88	920	367504	81681	46235957
Intentional product misuse	47.88	9.88	200	368224	46928	46270710
Encephalopathy	47.66	9.88	123	368301	33466	46284172
Poisoning deliberate	47.55	9.88	4	368420	7922	46309716
Pain in extremity	47.52	9.88	2496	365928	256184	46061454
Tremor	47.40	9.88	635	367789	115004	46202634
Disorientation	47.32	9.88	142	368282	36776	46280862
Coma	46.92	9.88	269	368155	58080	46259558
Caesarean section	46.51	9.88	256	368168	16347	46301291
Joint laxity	46.10	9.88	69	368355	2027	46315611
Sedation	45.35	9.88	69	368355	22841	46294797
Anaphylactic reaction	44.81	9.88	241	368183	52871	46264767
Psoriasis	44.70	9.88	870	367554	77734	46239904
Hepatic function abnormal	44.40	9.88	132	368292	34289	46283349
Hyperglycaemia	44.16	9.88	136	368288	34935	46282703
Upper respiratory tract infection	44.13	9.88	726	367698	62830	46254808
Respiratory failure	43.60	9.88	508	367916	94308	46223330
Maternal drugs affecting foetus	43.19	9.88	118	368306	5400	46312238
Thrombocytopenia	42.95	9.88	721	367703	125860	46191778
Hyperkalaemia	42.83	9.88	230	368194	50479	46267159
Mydriasis	42.57	9.88	15	368409	10538	46307100
Diabetic ketoacidosis	42.00	9.88	49	368375	18161	46299477
Blood pressure diastolic abnormal	41.91	9.88	127	368297	6167	46311471
Injection site bruising	41.87	9.88	448	367976	35188	46282450
Hypothermia	41.71	9.88	22	368402	12161	46305477
Hypoxia	41.67	9.88	239	368185	51599	46266039
Night sweats	41.60	9.88	362	368062	26888	46290750
Body temperature increased	41.53	9.88	337	368087	24524	46293114
Syncope	40.97	9.88	581	367843	104222	46213416
Food allergy	40.75	9.88	134	368290	6799	46310839
Extrapyramidal disorder	40.61	9.88	19	368405	11249	46306389
Palmar-plantar erythrodysaesthesia syndrome	40.09	9.88	62	368362	20389	46297249
Torsade de pointes	40.08	9.88	23	368401	12131	46305507
Oropharyngeal pain	39.86	9.88	814	367610	73354	46244284
Seizure	39.79	9.88	707	367717	122347	46195291
Hallucination	39.78	9.88	231	368193	49720	46267918
Nausea	39.14	9.88	4791	363633	682663	45634975
Osteonecrosis of jaw	38.79	9.88	140	368284	34262	46283376
Live birth	38.71	9.88	173	368251	10157	46307481
Schizophrenia	38.51	9.88	10	368414	8558	46309080
Localised infection	38.35	9.88	320	368104	23481	46294157
Weight increased	38.05	9.88	1624	366800	162849	46154789
Injection site rash	37.92	9.88	234	368190	15579	46302059
Neck deformity	37.90	9.88	59	368365	1795	46315843
No adverse event	37.49	9.88	141	368283	34090	46283548
Pre-eclampsia	37.12	9.88	143	368281	7851	46309787
Acute hepatic failure	36.85	9.88	37	368387	14684	46302954
Altered state of consciousness	36.70	9.88	81	368343	23267	46294371
Shock	36.68	9.88	73	368351	21772	46295866
Ejection fraction decreased	36.50	9.88	53	368371	17884	46299754
Leukopenia	36.33	9.88	354	368070	67989	46249649
Foot deformity	35.58	9.88	226	368198	15199	46302439
Anxiety	35.55	9.88	1129	367295	180828	46136810
Somnolence	35.38	9.88	952	367472	155569	46162069
Gamma-glutamyltransferase increased	35.24	9.88	130	368294	31610	46286028
Oral herpes	35.23	9.88	268	368156	19122	46298516
Gestational diabetes	35.06	9.88	131	368293	7088	46310550
Disseminated intravascular coagulation	35.02	9.88	60	368364	18945	46298693
Abnormal behaviour	34.81	9.88	71	368353	20987	46296651
Loss of personal independence in daily activities	34.59	9.88	639	367785	56544	46261094
Blood creatine phosphokinase increased	34.56	9.88	108	368316	27616	46290022
Premature labour	34.23	9.88	178	368246	11121	46306517
Ear pain	34.00	9.88	294	368130	21798	46295840
Coeliac disease	33.99	9.88	129	368295	7032	46310606
Influenza	33.96	9.88	934	367490	88336	46229302
Suicidal ideation	33.92	9.88	283	368141	56099	46261539
Psychotic disorder	33.52	9.88	81	368343	22540	46295098
Contusion	33.18	9.88	915	367509	86572	46231066
Juvenile idiopathic arthritis	32.98	9.88	89	368335	4043	46313595
Red blood cell sedimentation rate increased	32.85	9.88	300	368124	22589	46295049
Bronchitis	32.82	9.88	1081	367343	104898	46212740
Off label use	32.77	9.88	2567	365857	377274	45940364
Neuroleptic malignant syndrome	32.66	9.88	24	368400	11098	46306540
Limb deformity	32.63	9.88	81	368343	3495	46314143
Muscle spasticity	32.45	9.88	177	368247	11263	46306375
Metastases to bone	32.36	9.88	55	368369	17421	46300217
Rheumatoid nodule	32.26	9.88	149	368275	8871	46308767
Anaphylactic shock	32.14	9.88	70	368354	20204	46297434
Herpes zoster	32.01	9.88	731	367693	67141	46250497
Blood pressure systolic abnormal	31.86	9.88	106	368318	5411	46312227
Metastases to liver	31.56	9.88	67	368357	19518	46298120
Loss of consciousness	31.55	9.88	633	367791	107605	46210033
Dizziness	31.34	9.88	2288	366136	338126	45979512
Cellulitis	30.99	9.88	750	367674	69538	46248100
Drug level increased	30.64	9.88	62	368362	18379	46299259
Blood bilirubin increased	30.59	9.88	152	368272	34032	46283606
Transplant rejection	30.46	9.88	19	368405	9577	46308061
Multiple fractures	30.43	9.88	105	368319	5462	46312176
Therapeutic response decreased	30.37	9.88	494	367930	42651	46274987
Ventricular tachycardia	29.97	9.88	55	368369	16912	46300726
Cystitis	29.86	9.88	484	367940	41757	46275881
Carpal tunnel syndrome	29.83	9.88	221	368203	15638	46302000
Pyrexia	29.64	9.88	2360	366064	346442	45971196
Akathisia	29.39	9.88	12	368412	7702	46309936
Grip strength decreased	29.20	9.88	140	368284	8466	46309172
Intramedullary rod insertion	29.17	9.88	57	368367	2086	46315552
Nodule	29.09	9.88	217	368207	15388	46302250
Cardiac failure congestive	29.06	9.88	529	367895	91221	46226417
Toxic skin eruption	28.92	9.88	33	368391	12354	46305284
Posterior reversible encephalopathy syndrome	28.64	9.88	47	368377	15094	46302544
Arthritis infective	28.44	9.88	97	368327	5016	46312622
Neurotoxicity	28.43	9.88	40	368384	13677	46303961
Inappropriate antidiuretic hormone secretion	28.37	9.88	42	368382	14060	46303578
Skin cancer	28.13	9.88	141	368283	8682	46308956
Accidental overdose	28.07	9.88	74	368350	19992	46297646
Agranulocytosis	27.95	9.88	86	368338	22099	46295539
Hypokalaemia	27.73	9.88	508	367916	87516	46230122
Angioedema	27.68	9.88	189	368235	39153	46278485
Hypersensitivity	27.66	9.88	1451	366973	148870	46168768
Premature delivery	27.60	9.88	281	368143	21788	46295850
Ventricular septal defect	27.42	9.88	82	368342	3952	46313686
Smear cervix abnormal	27.33	9.88	61	368363	2455	46315183
Vomiting	27.26	9.88	3143	365281	449651	45867987
Febrile bone marrow aplasia	27.26	9.88	10	368414	6852	46310786
Blood creatinine increased	26.95	9.88	432	367992	75971	46241667
Malignant melanoma	26.82	9.88	155	368269	10079	46307559
Small for dates baby	26.71	9.88	76	368348	3561	46314077
Acute generalised exanthematous pustulosis	26.71	9.88	21	368403	9384	46308254
Aggression	26.69	9.88	91	368333	22653	46294985
Fibromyalgia	26.60	9.88	420	368004	36043	46281595
Unresponsive to stimuli	26.58	9.88	147	368277	32027	46285611
Heart rate decreased	26.50	9.88	374	368050	31349	46286289
Blood pressure diastolic increased	26.23	9.88	105	368319	5869	46311769
Blood pressure diastolic decreased	26.15	9.88	197	368227	14014	46303624
Injection site warmth	25.95	9.88	192	368232	13580	46304058
Respiratory depression	25.91	9.88	32	368392	11568	46306070
Anaemia	25.85	9.88	1705	366719	254074	46063564
Mental status changes	25.80	9.88	185	368239	37903	46279735
Disturbance in attention	25.63	9.88	145	368279	31415	46286223
Myocardial infarction	25.61	9.88	580	367844	96948	46220690
Thrombotic microangiopathy	25.61	9.88	17	368407	8289	46309349
Neck mass	25.35	9.88	70	368354	3223	46314415
Foetal exposure during pregnancy	25.08	9.88	361	368063	30386	46287252
Developmental hip dysplasia	25.08	9.88	40	368384	1243	46316395
Dysarthria	24.99	9.88	183	368241	37315	46280323
Bone marrow failure	24.81	9.88	135	368289	29534	46288104
Gastroenteritis viral	24.75	9.88	235	368189	17884	46299754
Tuberculosis	24.68	9.88	152	368272	10113	46307525
Dry eye	24.34	9.88	355	368069	29967	46287671
Surgery	24.30	9.88	340	368084	28445	46289193
Musculoskeletal pain	24.25	9.88	725	367699	69403	46248235
Graft versus host disease	23.91	9.88	11	368413	6577	46311061
Ischaemic stroke	23.90	9.88	61	368363	16661	46300977
Bone erosion	23.44	9.88	141	368283	9302	46308336
Skin ulcer	23.35	9.88	373	368051	32085	46285553
Status epilepticus	23.22	9.88	47	368377	13932	46303706
Rash	23.22	9.88	3181	365243	353331	45964307
Joint stiffness	23.21	9.88	321	368103	26787	46290851
Synovial cyst	23.14	9.88	117	368307	7229	46310409
Mania	23.11	9.88	31	368393	10815	46306823
Polyneuropathy	23.11	9.88	35	368389	11609	46306029
Acute myeloid leukaemia	22.98	9.88	57	368367	15721	46301917
Premature rupture of membranes	22.94	9.88	82	368342	4341	46313297
Face oedema	22.90	9.88	76	368348	19077	46298561
Multiple sclerosis relapse	22.89	9.88	217	368207	41908	46275730
Enthesopathy	22.69	9.88	85	368339	4605	46313033
Cyst	22.41	9.88	168	368256	11932	46305706
Weight decreased	22.15	9.88	1942	366482	208907	46108731
Treatment failure	22.14	9.88	922	367502	92165	46225473
Tenosynovitis stenosans	22.01	9.88	48	368376	1901	46315737
Restlessness	21.98	9.88	115	368309	25409	46292229
Postoperative wound infection	21.92	9.88	131	368293	8622	46309016
Neuropathy peripheral	21.80	9.88	548	367876	90345	46227293
Dyspnoea exertional	21.75	9.88	273	368151	50016	46267622
Acute graft versus host disease	21.72	9.88	3	368421	4027	46313611
Hallucination, auditory	21.67	9.88	32	368392	10724	46306914
Rash maculo-papular	21.61	9.88	130	368294	27744	46289894
Foot fracture	21.54	9.88	243	368181	19339	46298299
Joint destruction	21.51	9.88	63	368361	3001	46314637
Hiatus hernia	21.46	9.88	230	368194	18072	46299566
Drug-induced liver injury	21.45	9.88	115	368309	25253	46292385
Nightmare	21.15	9.88	64	368360	16534	46301104
Joint range of motion decreased	21.08	9.88	197	368227	14927	46302711
Cataract	21.05	9.88	488	367936	44927	46272711
Parkinsonism	21.03	9.88	19	368405	7929	46309709
Forced expiratory volume decreased	21.03	9.88	7	368417	5097	46312541
Neoplasm progression	20.92	9.88	124	368300	26559	46291079
Dyskinesia	20.83	9.88	138	368286	28787	46288851
Tachypnoea	20.78	9.88	52	368372	14299	46303339
Inflammation	20.75	9.88	518	367906	48263	46269375
Ear infection	20.72	9.88	275	368149	22738	46294900
Brain oedema	20.69	9.88	42	368382	12436	46305202
Respiratory distress	20.67	9.88	157	368267	31759	46285879
Diabetes mellitus inadequate control	20.64	9.88	46	368378	13168	46304470
Cerebral haemorrhage	20.61	9.88	135	368289	28236	46289402
Jaundice	20.58	9.88	138	368286	28707	46288931
Fracture delayed union	20.52	9.88	50	368374	2132	46315506
Aspartate aminotransferase increased	20.39	9.88	469	367955	78231	46239407
Impaired quality of life	20.27	9.88	64	368360	3178	46314460
Haemoglobin decreased	20.26	9.88	1227	367197	127722	46189916
Serum ferritin increased	20.19	9.88	89	368335	5194	46312444
Wheezing	20.14	9.88	298	368126	53088	46264550
Immune reconstitution inflammatory syndrome	20.10	9.88	10	368414	5715	46311923
Device dislocation	20.05	9.88	96	368328	21706	46295932
Hypomania	19.95	9.88	5	368419	4383	46313255
Obstructive airways disorder	19.89	9.88	48	368376	13364	46304274
Eosinophilia	19.86	9.88	81	368343	19136	46298502
Speech disorder	19.78	9.88	186	368238	35981	46281657
Skin papilloma	19.63	9.88	75	368349	4101	46313537
Myalgia	19.62	9.88	783	367641	122305	46195333
Latent tuberculosis	19.60	9.88	46	368378	1914	46315724
Swollen joint count increased	19.46	9.88	52	368372	2348	46315290
Squamous cell carcinoma	19.45	9.88	117	368307	7719	46309919
Blood pressure systolic increased	19.30	9.88	327	368097	28460	46289178
Pancreatitis acute	19.28	9.88	116	368308	24756	46292882
Tenderness	19.26	9.88	211	368213	16670	46300968
Device use error	19.20	9.88	8	368416	5073	46312565
Alanine aminotransferase increased	19.19	9.88	541	367883	87910	46229728
Blood pressure increased	19.11	9.88	1201	367223	125465	46192173
Bronchospasm	19.01	9.88	62	368362	15645	46301993
Polyhydramnios	19.01	9.88	46	368378	1953	46315685
Psychomotor hyperactivity	18.98	9.88	29	368395	9584	46308054
Cardiogenic shock	18.92	9.88	66	368358	16318	46301320
Blood iron increased	18.85	9.88	36	368388	1295	46316343
Fracture	18.85	9.88	206	368218	16265	46301373
Ventricular fibrillation	18.80	9.88	39	368385	11457	46306181
Laryngitis	18.78	9.88	132	368292	9184	46308454
Miosis	18.74	9.88	15	368409	6642	46310996
Oliguria	18.70	9.88	25	368399	8734	46308904
Placental disorder	18.60	9.88	37	368387	1372	46316266
Rheumatic fever	18.58	9.88	57	368367	2786	46314852
Low turnover osteopathy	18.52	9.88	75	368349	4214	46313424
Substance abuse	18.47	9.88	5	368419	4162	46313476
Rotator cuff repair	18.39	9.88	38	368386	1449	46316189
Transplant dysfunction	18.30	9.88	7	368417	4675	46312963
Blood alkaline phosphatase increased	18.28	9.88	212	368212	39397	46278241
Eye infection	18.24	9.88	129	368295	8994	46308644
Joint noise	18.20	9.88	61	368363	3126	46314512
Rhinorrhoea	18.20	9.88	499	367925	47166	46270472
Accidental exposure to product	18.14	9.88	95	368329	20986	46296652
Ascites	17.99	9.88	193	368231	36391	46281247
Joint injury	17.91	9.88	231	368193	18978	46298660
Stress cardiomyopathy	17.89	9.88	21	368403	7763	46309875
Blood glucose increased	17.86	9.88	432	367992	71581	46246057
Haematotoxicity	17.84	9.88	17	368407	6916	46310722
Myoclonus	17.82	9.88	56	368368	14296	46303342
Haemorrhage	17.80	9.88	315	368109	54554	46263084
Congenital arterial malformation	17.78	9.88	18	368406	349	46317289
Tardive dyskinesia	17.71	9.88	20	368404	7523	46310115
Breast feeding	17.68	9.88	28	368396	865	46316773
Asphyxia	17.67	9.88	10	368414	5316	46312322
Catatonia	17.67	9.88	4	368420	3758	46313880
Myocarditis	17.66	9.88	21	368403	7718	46309920
Injection site haematoma	17.63	9.88	95	368329	6017	46311621
Cerebral infarction	17.58	9.88	110	368314	23256	46294382
Metastases to central nervous system	17.57	9.88	39	368385	11182	46306456
Plasma cell myeloma	17.57	9.88	246	368178	44232	46273406
Erythema multiforme	17.55	9.88	31	368393	9673	46307965
Acute chest syndrome	17.42	9.88	22	368402	548	46317090
Lupus vasculitis	17.31	9.88	20	368404	453	46317185
Viral infection	17.29	9.88	335	368089	29900	46287738
Oedema	17.28	9.88	400	368024	66671	46250967
Bone density decreased	17.28	9.88	134	368290	9618	46308020
Hypocalcaemia	17.23	9.88	132	368292	26653	46290985
Second primary malignancy	17.11	9.88	16	368408	6568	46311070
Polyarthritis	17.09	9.88	99	368325	6443	46311195
Bone disorder	17.06	9.88	237	368187	19796	46297842
Ketoacidosis	17.06	9.88	5	368419	3950	46313688
Shock haemorrhagic	17.04	9.88	26	368398	8598	46309040
Haemorrhage intracranial	16.99	9.88	48	368376	12676	46304962
Muscle rigidity	16.97	9.88	33	368391	9928	46307710
Melaena	16.88	9.88	139	368285	27633	46290005
Pleural effusion	16.83	9.88	512	367912	82440	46235198
Uterine contractions during pregnancy	16.82	9.88	21	368403	517	46317121
Renal injury	16.79	9.88	31	368393	9510	46308128
Synovial fluid analysis	16.77	9.88	35	368389	1344	46316294
Loose body in joint	16.76	9.88	30	368394	1026	46316612
Foot operation	16.76	9.88	78	368346	4659	46312979
Immunosuppression	16.75	9.88	109	368315	7391	46310247
Body tinea	16.72	9.88	28	368396	907	46316731
Haemophagocytic lymphohistiocytosis	16.63	9.88	25	368399	8317	46309321
Pathogen resistance	16.63	9.88	14	368410	6046	46311592
Wrist fracture	16.62	9.88	151	368273	11352	46306286
Tooth infection	16.61	9.88	159	368265	12127	46305511
Knee operation	16.51	9.88	78	368346	4688	46312950
Pharyngitis streptococcal	16.50	9.88	119	368305	8349	46309289
Gallbladder polyp	16.46	9.88	25	368399	744	46316894
Wheelchair user	16.45	9.88	69	368355	3939	46313699
Arrhythmia	16.26	9.88	186	368238	34655	46282983
Clear cell renal cell carcinoma	16.24	9.88	29	368395	990	46316648
International normalised ratio increased	16.23	9.88	266	368158	46617	46271021
Epilepsy	16.22	9.88	115	368309	23623	46294015
Injection site irritation	16.21	9.88	72	368352	4215	46313423
Product administration error	16.21	9.88	90	368334	19591	46298047
Urinary tract infection	16.16	9.88	1980	366444	218286	46099352
Tumour lysis syndrome	16.12	9.88	20	368404	7216	46310422
Synovial disorder	16.12	9.88	26	368398	816	46316822
Anuria	16.10	9.88	42	368382	11389	46306249
Body height below normal	16.09	9.88	41	368383	1798	46315840
Metastases to lung	16.08	9.88	38	368386	10658	46306980
Pulmonary tuberculosis	16.08	9.88	77	368347	4654	46312984
Injection site haemorrhage	16.05	9.88	241	368183	20468	46297170
Device difficult to use	15.94	9.88	24	368400	7980	46309658
Cervical incompetence	15.88	9.88	22	368402	601	46317037
Pemphigoid	15.80	9.88	13	368411	5678	46311960
Gestational hypertension	15.80	9.88	45	368379	2110	46315528
Hallucination, visual	15.69	9.88	80	368344	17793	46299845
Cestode infection	15.62	9.88	15	368409	272	46317366
Blood pressure decreased	15.55	9.88	338	368086	56821	46260817
Neutrophil count decreased	15.49	9.88	245	368179	43181	46274457
Endodontic procedure	15.48	9.88	49	368375	2436	46315202
Disability	15.48	9.88	135	368289	10032	46307606
Cytomegalovirus viraemia	15.46	9.88	8	368416	4470	46313168
Complication of device insertion	15.40	9.88	10	368414	4934	46312704
Bronchopulmonary aspergillosis	15.40	9.88	22	368402	7474	46310164
Acute pulmonary oedema	15.39	9.88	24	368400	7867	46309771
Hemiparesis	15.34	9.88	94	368330	19975	46297663
Intervertebral disc degeneration	15.28	9.88	166	368258	13086	46304552
Exomphalos	15.21	9.88	20	368404	519	46317119
Cytokine release syndrome	15.17	9.88	16	368408	6207	46311431
Crystal nephropathy	15.15	9.88	25	368399	800	46316838
Coagulopathy	15.02	9.88	85	368339	18414	46299224
Hypomagnesaemia	14.98	9.88	108	368316	22102	46295536
Pulmonary hypertension	14.97	9.88	197	368227	35796	46281842
Deafness transitory	14.93	9.88	37	368387	1595	46316043
Stevens-Johnson syndrome	14.90	9.88	115	368309	23182	46294456
Withdrawal syndrome	14.90	9.88	83	368341	18051	46299587
Cyanosis	14.88	9.88	70	368354	15901	46301737
Limb injury	14.81	9.88	223	368201	18951	46298687
Atrial septal defect	14.74	9.88	93	368331	6239	46311399
Sinus tachycardia	14.74	9.88	105	368319	21544	46296094
Toxic epidermal necrolysis	14.71	9.88	109	368315	22169	46295469
Decreased appetite	14.55	9.88	1324	367100	192512	46125126
Aspergillus infection	14.37	9.88	20	368404	6870	46310768
Infective pulmonary exacerbation of cystic fibrosis	14.26	9.88	41	368383	10766	46306872
Induced labour	14.15	9.88	26	368398	908	46316730
Atrioventricular block complete	14.12	9.88	24	368400	7603	46310035
Bradyphrenia	14.11	9.88	17	368407	6213	46311425
Drug ineffective for unapproved indication	14.10	9.88	74	368350	16339	46301299
Gastrointestinal pain	14.09	9.88	104	368320	7351	46310287
Red blood cell count decreased	14.04	9.88	347	368077	32276	46285362
Pulmonary embolism	13.98	9.88	707	367717	107878	46209760
Injection site urticaria	13.85	9.88	150	368274	11817	46305821
Glycosylated haemoglobin increased	13.81	9.88	42	368382	10834	46306804
Asthma	13.80	9.88	586	367838	90956	46226682
Diverticulitis	13.80	9.88	350	368074	32689	46284949
Foetal death	13.79	9.88	117	368307	8626	46309012
Post procedural infection	13.74	9.88	104	368320	7409	46310229
Lymphadenectomy	13.64	9.88	25	368399	871	46316767
Laryngospasm	13.61	9.88	3	368421	2870	46314768
Gastrooesophageal reflux disease	13.53	9.88	717	367707	73627	46244011
Spinal stenosis	13.50	9.88	155	368269	12388	46305250
Back pain	13.50	9.88	1873	366551	208166	46109472
Wound infection	13.48	9.88	133	368291	10226	46307412
Chronic kidney disease	13.46	9.88	234	368190	40637	46277001
Scleritis	13.45	9.88	52	368372	2860	46314778
Pulmonary oedema	13.39	9.88	304	368120	50801	46266837
Pharyngitis	13.38	9.88	204	368220	17379	46300259
Osteopenia	13.38	9.88	198	368226	16763	46300875
Mouth ulceration	13.27	9.88	291	368133	26541	46291097
Inadequate analgesia	13.27	9.88	3	368421	2821	46314817
Pain in jaw	13.18	9.88	218	368206	38154	46279484
Cognitive disorder	13.18	9.88	208	368216	36675	46280963
Lung neoplasm malignant	13.09	9.88	183	368241	15306	46302332
Catheter management	13.07	9.88	3	368421	2792	46314846
Cholestasis of pregnancy	13.06	9.88	28	368396	1096	46316542
Maternal exposure during breast feeding	13.04	9.88	50	368374	2739	46314899
Condition aggravated	13.03	9.88	2162	366262	242890	46074748
Myopathy	13	9.88	32	368392	8849	46308789
Incoherent	12.91	9.88	10	368414	4502	46313136
Morning sickness	12.88	9.88	21	368403	665	46316973
Haematocrit decreased	12.82	9.88	365	368059	34692	46282946
Hyperuricaemia	12.82	9.88	11	368413	4706	46312932
Product prescribing error	12.80	9.88	99	368325	19948	46297690
Product substitution issue	12.79	9.88	68	368356	14963	46302675
Cardiac failure acute	12.71	9.88	28	368396	8050	46309588
Palpitations	12.70	9.88	618	367806	94641	46222997
Vertigo	12.69	9.88	313	368111	51735	46265903
Haematoma	12.69	9.88	176	368248	31696	46285942
Dehydration	12.66	9.88	1085	367339	158455	46159183
Bone density abnormal	12.59	9.88	53	368371	3031	46314607
Orthostatic hypotension	12.57	9.88	129	368295	24529	46293109
Mass	12.54	9.88	144	368280	11509	46306129
Stillbirth	12.52	9.88	91	368333	6400	46311238
Poor venous access	12.49	9.88	110	368314	8198	46309440
Lip swelling	12.48	9.88	134	368290	25261	46292377
Proteinuria	12.41	9.88	78	368346	16475	46301163
Hypertransaminasaemia	12.39	9.88	6	368418	3482	46314156
Hepatitis cholestatic	12.37	9.88	21	368403	6656	46310982
Disease recurrence	12.37	9.88	90	368334	18381	46299257
Cartilage injury	12.35	9.88	34	368390	1563	46316075
Sickle cell anaemia	12.33	9.88	19	368405	573	46317065
Paralysis	12.32	9.88	32	368392	8689	46308949
Metabolic surgery	12.24	9.88	25	368399	945	46316693
Labelled drug-drug interaction medication error	12.23	9.88	34	368390	9027	46308611
Potentiating drug interaction	12.13	9.88	8	368416	3915	46313723
Human antichimeric antibody positive	12.09	9.88	31	368393	1365	46316273
Antinuclear antibody positive	12.09	9.88	88	368336	6192	46311446
Dysphagia	12.06	9.88	493	367931	76819	46240819
Cerebrovascular accident	12.04	9.88	663	367761	100376	46217262
Tubulointerstitial nephritis	11.98	9.88	68	368356	14720	46302918
Antibody test positive	11.98	9.88	41	368383	2124	46315514
Congenital neuropathy	11.98	9.88	5	368419	17	46317621
Interstitial lung disease	11.95	9.88	329	368095	53620	46264018
Talipes	11.93	9.88	31	368393	1376	46316262
Sinus bradycardia	11.92	9.88	62	368362	13720	46303918
Cardiomyopathy	11.92	9.88	76	368348	15997	46301641
Crying	11.87	9.88	108	368316	21033	46296605
Ileus paralytic	11.84	9.88	10	368414	4313	46313325
Irritability	11.83	9.88	159	368265	28787	46288851
Septic shock	11.82	9.88	357	368067	57536	46260102
Infection susceptibility increased	11.82	9.88	41	368383	2138	46315500
Colitis microscopic	11.80	9.88	21	368403	6535	46311103
Wrong technique in product usage process	11.77	9.88	333	368091	54089	46263549
Renal mass	11.71	9.88	36	368388	1762	46315876
Diabetes mellitus	11.69	9.88	303	368121	49762	46267876
Cardiotoxicity	11.69	9.88	22	368402	6700	46310938
Delusion	11.66	9.88	47	368377	11141	46306497
Hyperthermia	11.63	9.88	29	368395	7985	46309653
Tooth disorder	11.61	9.88	253	368171	23050	46294588
Cushingoid	11.60	9.88	87	368337	6179	46311459
Magnesium deficiency	11.58	9.88	16	368408	436	46317202
Hysterectomy	11.55	9.88	103	368321	7703	46309935
Infective thrombosis	11.55	9.88	3	368421	0	46317638
Protein total	11.55	9.88	3	368421	0	46317638
Dermatitis exfoliative	11.52	9.88	17	368407	5699	46311939
Hepatotoxicity	11.48	9.88	134	368290	24875	46292763
Catheter site pain	11.45	9.88	8	368416	3798	46313840
Abdominal pain upper	11.42	9.88	1312	367112	143993	46173645
Graft versus host disease in gastrointestinal tract	11.41	9.88	3	368421	2547	46315091
Arthritis bacterial	11.40	9.88	81	368343	5655	46311983
Emotional distress	11.37	9.88	172	368252	30535	46287103
Lip pruritus	11.37	9.88	17	368407	499	46317139
Drug ineffective	11.30	9.88	5698	362726	672140	45645498
Dystonia	11.29	9.88	48	368376	11209	46306429
Pancreatitis	11.29	9.88	260	368164	43367	46274271
Joint lock	11.26	9.88	39	368385	2032	46315606
Sepsis	11.24	9.88	922	367502	135092	46182546
Atrioventricular block	11.23	9.88	23	368401	6788	46310850
Ingrown hair	11.15	9.88	16	368408	452	46317186
Epstein-Barr virus infection	11.11	9.88	23	368401	6761	46310877
Bradykinesia	11.08	9.88	9	368415	3957	46313681
Joint dislocation	11.06	9.88	136	368288	11050	46306588
Foetal distress syndrome	11.03	9.88	28	368396	1225	46316413
Hospitalisation	11.02	9.88	399	368025	62986	46254652
Abortion incomplete	11.02	9.88	6	368418	3258	46314380
Chest discomfort	11	9.88	591	367833	89678	46227960
Skin laceration	10.92	9.88	206	368218	18296	46299342
Platelet count decreased	10.90	9.88	662	367762	99362	46218276
Dactylitis	10.86	9.88	27	368397	1166	46316472
Joint warmth	10.83	9.88	28	368396	1239	46316399
Drug abuser	10.83	9.88	6	368418	3227	46314411
Gonorrhoea	10.82	9.88	9	368415	134	46317504
Depression	10.80	9.88	1176	367248	168928	46148710
Respiratory acidosis	10.80	9.88	20	368404	6128	46311510
Chronic graft versus host disease	10.78	9.88	4	368420	2721	46314917
Anterior chamber cleavage syndrome	10.75	9.88	10	368414	174	46317464
Vascular rupture	10.73	9.88	28	368396	1246	46316392
Upper limb fracture	10.72	9.88	179	368245	15534	46302104
Product compounding quality issue	10.71	9.88	9	368415	136	46317502
Urinary retention	10.70	9.88	143	368281	25918	46291720
Chondropathy	10.63	9.88	37	368387	1933	46315705
Stress	10.58	9.88	503	367921	51048	46266590
Musculoskeletal disorder	10.57	9.88	177	368247	15368	46302270
Device breakage	10.56	9.88	40	368384	9652	46307986
Maternal exposure before pregnancy	10.55	9.88	66	368358	4415	46313223
Hyperprolactinaemia	10.48	9.88	5	368419	2927	46314711
Complication associated with device	10.46	9.88	75	368349	15366	46302272
Hepatitis fulminant	10.44	9.88	7	368417	3395	46314243
Incorrect route of product administration	10.42	9.88	81	368343	16302	46301336
Forceps delivery	10.34	9.88	10	368414	183	46317455
Sciatica	10.29	9.88	209	368215	18811	46298827
Paradoxical drug reaction	10.25	9.88	3	368421	2373	46315265
Spinal cord neoplasm	10.25	9.88	11	368413	229	46317409
Tendon disorder	10.20	9.88	71	368353	4924	46312714
Genital haemorrhage	10.14	9.88	23	368401	6543	46311095
Acute myocardial infarction	10.12	9.88	184	368240	31740	46285898
Intracranial pressure increased	10.12	9.88	11	368413	4209	46313429
Vacuum extractor delivery	10.09	9.88	9	368415	148	46317490
Dermatitis bullous	10.08	9.88	29	368395	7614	46310024
Hernia	10.08	9.88	119	368305	9576	46308062
Haemorrhage in pregnancy	10.05	9.88	32	368392	1596	46316042
Hepatic necrosis	10.03	9.88	18	368406	5583	46312055
Foetal anticonvulsant syndrome	10.01	9.88	15	368409	441	46317197
Catheter site erythema	9.98	9.88	10	368414	3973	46313665
Tooth fracture	9.98	9.88	116	368308	9299	46308339
Spinal disorder	9.95	9.88	102	368322	7922	46309716
Acute coronary syndrome	9.93	9.88	44	368380	10160	46307478
Complication of pregnancy	9.90	9.88	16	368408	503	46317135

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid arthritis	349.20	9.99	723	162057	40474	29749224
Drug abuse	310.08	9.99	40	162740	82032	29707666
Toxicity to various agents	292.78	9.99	319	162461	176864	29612834
Completed suicide	275.93	9.99	98	162682	99394	29690304
Arthralgia	179.61	9.99	1308	161472	134483	29655215
Drug interaction	161.99	9.99	550	162230	199018	29590680
Foetal exposure during pregnancy	156.94	9.99	499	162281	36372	29753326
Intentional overdose	118.12	9.99	39	162741	41442	29748256
Psoriatic arthropathy	115.55	9.99	261	162519	15500	29774198
Joint swelling	99.96	9.99	512	162268	46434	29743264
Nasopharyngitis	89.50	9.99	587	162193	58262	29731436
Overdose	85.41	9.99	209	162571	84128	29705570
Sickle cell anaemia with crisis	83.60	9.99	83	162697	2319	29787379
Acute kidney injury	77.60	9.99	1036	161744	272806	29516892
Premature baby	72.91	9.99	228	162552	16463	29773235
Suicide attempt	72.37	9.99	56	162724	36641	29753057
Exposure during pregnancy	67.47	9.99	153	162627	9108	29780590
Drug reaction with eosinophilia and systemic symptoms	62.09	9.99	39	162741	28449	29761249
Rhabdomyolysis	59.42	9.99	164	162616	63416	29726282
Neonatal respiratory distress syndrome	59.41	9.99	90	162690	3922	29785776
Haemoglobin decreased	59.41	9.99	910	161870	113188	29676510
Blood pressure fluctuation	57.96	9.99	218	162562	17285	29772413
Hepatic function abnormal	57.21	9.99	87	162693	41858	29747840
Serotonin syndrome	56.12	9.99	14	162766	17877	29771821
Tenosynovitis	55.13	9.99	81	162699	3434	29786264
Musculoskeletal stiffness	53.37	9.99	356	162424	35525	29754173
Enthesopathy	53.03	9.99	72	162708	2834	29786864
Death	51.82	9.99	1513	161267	355770	29433928
Atrial septal defect	50.26	9.99	112	162668	6589	29783109
Infusion related reaction	47.44	9.99	380	162400	40184	29749514
Pain	46.87	9.99	1249	161531	171392	29618306
Maternal drugs affecting foetus	45.95	9.99	83	162697	4190	29785508
Respiratory arrest	45.65	9.99	55	162725	29203	29760495
Intentional product misuse	45.29	9.99	74	162706	34593	29755105
Product use in unapproved indication	44.71	9.99	227	162553	73466	29716232
Arthritis	44.39	9.99	255	162525	24146	29765552
Coma	44.34	9.99	96	162684	40353	29749345
Cytomegalovirus infection	41.95	9.99	40	162740	23634	29766064
Psoriasis	41.72	9.99	383	162397	42123	29747575
Coombs positive haemolytic anaemia	41.61	9.99	34	162746	731	29788967
Febrile neutropenia	41.10	9.99	376	162404	106317	29683381
Hypospadias	40.96	9.99	61	162719	2618	29787080
Cardiac failure	40.48	9.99	276	162504	83142	29706556
Maternal exposure during breast feeding	38.59	9.99	46	162734	1586	29788112
Basal cell carcinoma	38.28	9.99	181	162599	15887	29773811
Hypoglycaemia neonatal	38.06	9.99	45	162735	1538	29788160
Intentional self-injury	38.03	9.99	13	162767	13519	29776179
Maternal exposure during pregnancy	37.63	9.99	72	162708	3799	29785899
Low birth weight baby	37.37	9.99	94	162686	5982	29783716
Cardiac arrest	36.72	9.99	325	162455	92525	29697173
Renal failure	36.72	9.99	487	162293	128479	29661219
Small for dates baby	36.67	9.99	64	162716	3144	29786554
Tongue disorder	35.57	9.99	75	162705	4247	29785451
Haemolysis	35.56	9.99	103	162677	7128	29782570
Immune reconstitution inflammatory syndrome	35.41	9.99	4	162776	9097	29780601
Dysmorphism	35.34	9.99	49	162731	1968	29787730
Ventricular septal defect	34.75	9.99	66	162714	3463	29786235
Renal impairment	34.47	9.99	292	162488	83892	29705806
Pain in extremity	34.18	9.99	812	161968	109409	29680289
Poisoning	33.64	9.99	10	162770	11372	29778326
Drug resistance	33.41	9.99	36	162744	20097	29769601
Synovitis	33.35	9.99	123	162657	9660	29780038
Grip strength decreased	32.62	9.99	49	162731	2119	29787579
Syndactyly	32.38	9.99	29	162751	709	29788989
Osteoarthritis	32.23	9.99	190	162590	18159	29771539
Lactic acidosis	31.84	9.99	77	162703	31136	29758562
Bradycardia	31.19	9.99	218	162562	65308	29724390
Angioedema	31.14	9.99	90	162690	34294	29755404
Arthropathy	31.02	9.99	206	162574	20521	29769177
C-reactive protein abnormal	29.78	9.99	82	162698	5511	29784187
Depressed level of consciousness	29.77	9.99	107	162673	38115	29751583
Suicidal ideation	29.54	9.99	99	162681	36015	29753683
Delirium	29.54	9.99	117	162663	40514	29749184
Pulmonary fibrosis	28.86	9.99	166	162614	15724	29773974
Cellulitis	28.63	9.99	384	162396	46400	29743298
Cryptorchism	28.28	9.99	40	162740	1637	29788061
Fatigue	28.27	9.99	2064	160716	318609	29471089
Agitation	28.20	9.99	175	162605	53898	29735800
Muscle swelling	27.71	9.99	20	162760	355	29789343
Substance abuse	27.63	9.99	3	162777	7037	29782661
Agranulocytosis	27.58	9.99	48	162732	21894	29767804
Blood pressure systolic abnormal	26.99	9.99	37	162743	1470	29788228
Peripheral swelling	26.88	9.99	474	162306	60600	29729098
Electrocardiogram QT prolonged	26.81	9.99	102	162678	35733	29753965
Large for dates baby	26.53	9.99	28	162752	842	29788856
Blood pressure increased	26.43	9.99	543	162237	71385	29718313
Drug dependence	26.39	9.99	47	162733	21248	29768450
Sedation	26.38	9.99	30	162750	16343	29773355
Exposure via breast milk	25.78	9.99	37	162743	1535	29788163
Weight decreased	25.63	9.99	1033	161747	149888	29639810
Foetal anticonvulsant syndrome	25.57	9.99	26	162754	748	29788950
Skin cancer	25.40	9.99	98	162682	7863	29781835
Lower respiratory tract infection	25.35	9.99	239	162541	26475	29763223
Sinusitis	25.30	9.99	285	162495	33060	29756638
Multiple organ dysfunction syndrome	25.18	9.99	222	162558	63265	29726433
Hypoglycaemia	25.05	9.99	168	162612	50813	29738885
Alanine aminotransferase abnormal	24.59	9.99	48	162732	2571	29787127
Drug withdrawal syndrome	24.30	9.99	44	162736	19765	29769933
Therapeutic product effect decreased	24.13	9.99	253	162527	28823	29760875
Poor venous access	23.95	9.99	46	162734	2434	29787264
Knee arthroplasty	23.75	9.99	76	162704	5554	29784144
Skin lesion	23.69	9.99	177	162603	18317	29771381
Cholestasis	23.56	9.99	64	162716	24886	29764812
Hepatocellular injury	23.56	9.99	66	162714	25405	29764293
Aggression	23.34	9.99	112	162668	36795	29752903
Lymphadenitis	23.26	9.99	37	162743	1683	29788015
Off label use	23.17	9.99	1113	161667	248177	29541521
Palmar-plantar erythrodysaesthesia syndrome	23.14	9.99	28	162752	14842	29774856
Vitamin D deficiency	22.92	9.99	71	162709	5099	29784599
Blood creatine phosphokinase increased	22.81	9.99	142	162638	43706	29745992
Pneumonia	22.74	9.99	2110	160670	332196	29457502
Blood pressure systolic increased	22.51	9.99	150	162630	14960	29774738
Rheumatoid nodule	22.36	9.99	36	162744	1654	29788044
Drug intolerance	21.92	9.99	357	162423	44934	29744764
Somnolence	21.83	9.99	382	162398	96381	29693317
Red blood cell count decreased	21.83	9.99	229	162551	26092	29763606
Congenital hand malformation	21.82	9.99	19	162761	447	29789251
Post procedural infection	21.41	9.99	64	162716	4508	29785190
Haematocrit decreased	21.34	9.99	258	162522	30441	29759257
Mass	21.25	9.99	86	162694	7054	29782644
Neuroleptic malignant syndrome	21.08	9.99	35	162745	16260	29773438
Influenza	20.98	9.99	342	162438	43056	29746642
Juvenile idiopathic arthritis	20.82	9.99	27	162753	1016	29788682
Serum ferritin increased	20.80	9.99	71	162709	5366	29784332
Cardio-respiratory arrest	20.74	9.99	205	162575	57101	29732597
Musculoskeletal pain	20.63	9.99	258	162522	30682	29759016
Shock	20.58	9.99	60	162720	22799	29766899
Oropharyngeal pain	20.47	9.99	241	162539	28255	29761443
Status epilepticus	20.45	9.99	18	162762	11054	29778644
Arthritis bacterial	20.44	9.99	62	162718	4402	29785296
Hyperglycaemia	19.90	9.99	111	162669	35089	29754609
Pancytopenia	19.87	9.99	604	162176	84448	29705250
Caesarean section	19.86	9.99	39	162741	2098	29787600
Selective eating disorder	19.78	9.99	34	162746	1650	29788048
Psychotic disorder	19.71	9.99	56	162724	21459	29768239
Medical device implantation	19.57	9.99	19	162761	516	29789182
Interstitial lung disease	19.50	9.99	221	162559	59976	29729722
Tendonitis	19.49	9.99	91	162689	7945	29781753
Immunodeficiency	19.06	9.99	59	162721	4235	29785463
Injection site pain	19.04	9.99	250	162530	30060	29759638
Incorrect route of product administration	19.03	9.99	20	162760	11295	29778403
Back pain	18.99	9.99	709	162071	101887	29687811
Tonsil cancer	18.74	9.99	22	162758	746	29788952
Kidney infection	18.59	9.99	61	162719	4517	29785181
Toxic epidermal necrolysis	18.50	9.99	44	162736	17896	29771802
Localised infection	18.47	9.99	133	162647	13604	29776094
Wound	18.40	9.99	123	162657	12279	29777419
Body temperature decreased	18.28	9.99	102	162678	9553	29780145
Agitation neonatal	18.11	9.99	25	162755	1000	29788698
Pyrexia	18.09	9.99	1367	161413	293122	29496576
Eosinophilia	17.95	9.99	61	162719	22099	29767599
Neutrophil count decreased	17.93	9.99	146	162634	42308	29747390
Mean cell volume increased	17.81	9.99	37	162743	2073	29787625
Full blood count decreased	17.69	9.99	146	162634	15571	29774127
Altered state of consciousness	17.41	9.99	53	162727	19866	29769832
Prostate cancer	17.38	9.99	203	162577	23754	29765944
Cytokine release syndrome	17.34	9.99	17	162763	9916	29779782
Talipes	17.33	9.99	32	162748	1643	29788055
Malignant melanoma	17.30	9.99	83	162697	7328	29782370
Loss of personal independence in daily activities	17.22	9.99	186	162594	21349	29768349
Hypocalcaemia	17.21	9.99	59	162721	21317	29768381
Hand deformity	17.19	9.99	34	162746	1839	29787859
Joint range of motion decreased	17.08	9.99	70	162710	5775	29783923
Foot deformity	16.94	9.99	49	162731	3388	29786310
Joint effusion	16.89	9.99	51	162729	3612	29786086
Speech disorder developmental	16.83	9.99	26	162754	1153	29788545
Drug level increased	16.65	9.99	48	162732	18306	29771392
Lacrimal disorder	16.49	9.99	14	162766	318	29789380
Urinary tract infection	16.38	9.99	520	162260	73139	29716559
Haemangioma congenital	16.17	9.99	17	162763	509	29789189
Akathisia	16.03	9.99	6	162774	5898	29783800
Venoocclusive liver disease	15.92	9.99	8	162772	6605	29783093
Diabetic ketoacidosis	15.86	9.99	40	162740	15946	29773752
Hepatic enzyme increased	15.83	9.99	263	162517	33231	29756467
Foetal growth restriction	15.68	9.99	49	162731	3536	29786162
Product quality issue	15.67	9.99	51	162729	18723	29770975
Acute hepatic failure	15.67	9.99	25	162755	11802	29777896
Hyperbilirubinaemia neonatal	15.58	9.99	19	162761	671	29789027
Injection site bruising	15.58	9.99	80	162700	7258	29782440
Rash maculo-papular	15.57	9.99	78	162702	25340	29764358
Neurotoxicity	15.53	9.99	30	162750	13152	29776546
Arthrodesis	15.43	9.99	15	162765	408	29789290
Congenital bladder anomaly	15.40	9.99	13	162767	293	29789405
Blood pressure diastolic increased	15.25	9.99	41	162739	2717	29786981
Anal fistula	15.20	9.99	52	162728	3934	29785764
Progressive multifocal leukoencephalopathy	15.08	9.99	16	162764	8997	29780701
Drug eruption	15.06	9.99	47	162733	17479	29772219
Asthma	15.01	9.99	125	162655	36049	29753649
Neck mass	14.88	9.99	27	162753	1368	29788330
Tachycardia	14.80	9.99	297	162483	73442	29716256
Multiple congenital abnormalities	14.80	9.99	16	162764	495	29789203
Crystal nephropathy	14.67	9.99	14	162766	372	29789326
Back disorder	14.62	9.99	68	162712	5926	29783772
Septic arthritis staphylococcal	14.46	9.99	15	162765	442	29789256
Cleft lip	14.44	9.99	13	162767	320	29789378
Spinal stenosis	14.40	9.99	54	162726	4275	29785423
Weight decrease neonatal	14.31	9.99	13	162767	324	29789374
Gamma-glutamyltransferase increased	14.27	9.99	97	162683	29253	29760445
Bradycardia neonatal	14.21	9.99	21	162759	895	29788803
Hypokalaemia	14.09	9.99	190	162590	50002	29739696
Jaundice neonatal	14.02	9.99	23	162757	1074	29788624
Ankyloglossia congenital	13.94	9.99	12	162768	278	29789420
Lipase increased	13.86	9.99	16	162764	8660	29781038
Blood pressure diastolic abnormal	13.84	9.99	25	162755	1262	29788436
Upper respiratory tract infection	13.83	9.99	218	162562	27258	29762440
Hypermobility syndrome	13.52	9.99	11	162769	235	29789463
Hepatic failure	13.51	9.99	119	162661	33924	29755774
Osteonecrosis of jaw	13.28	9.99	54	162726	18564	29771134
Cataract	13.26	9.99	179	162601	21656	29768042
Transaminases increased	13.24	9.99	74	162706	23383	29766315
Aspergillus infection	13.15	9.99	22	162758	10192	29779506
Foetal disorder	13.08	9.99	17	162763	641	29789057
Hepatocellular carcinoma	13.03	9.99	20	162760	9590	29780108
Cerebral haemorrhage	13.03	9.99	115	162665	32772	29756926
Pleural fibrosis	12.99	9.99	26	162754	1418	29788280
Hepatic encephalopathy	12.96	9.99	37	162743	14155	29775543
Hallucination	12.95	9.99	188	162592	48871	29740827
Nephrolithiasis	12.92	9.99	198	162582	24612	29765086
Frequent bowel movements	12.86	9.99	84	162696	8321	29781377
Immunosuppression	12.84	9.99	59	162721	5116	29784582
Acute graft versus host disease	12.81	9.99	8	162772	5856	29783842
Renal injury	12.71	9.99	28	162752	11701	29777997
Proteinuria	12.70	9.99	45	162735	16100	29773598
Renal aplasia	12.68	9.99	17	162763	661	29789037
Patent ductus arteriosus	12.67	9.99	42	162738	3127	29786571
Cystatin C increased	12.66	9.99	3	162777	0	29789698
Gastrointestinal tract mucosal discolouration	12.66	9.99	3	162777	0	29789698
Stevens-Johnson syndrome	12.47	9.99	51	162729	17505	29772193
Haemorrhage intracranial	12.43	9.99	41	162739	14991	29774707
Accidental overdose	12.42	9.99	54	162726	18221	29771477
Hepatitis	12.36	9.99	71	162709	22285	29767413
Heart rate decreased	12.30	9.99	171	162609	20823	29768875
Thrombocytopenia	12.27	9.99	614	162166	136430	29653268
Alcohol abuse	12.12	9.99	7	162773	5346	29784352
Drug-induced liver injury	12.07	9.99	67	162713	21207	29768491
Victim of child abuse	11.95	9.99	11	162769	279	29789419
Disseminated intravascular coagulation	11.95	9.99	71	162709	22100	29767598
Myoclonus	11.94	9.99	35	162745	13277	29776421
Posterior reversible encephalopathy syndrome	11.92	9.99	18	162762	8689	29781009
Pathogen resistance	11.90	9.99	17	162763	8393	29781305
Arthritis infective	11.88	9.99	37	162743	2665	29787033
Crohn's disease	11.84	9.99	51	162729	4301	29785397
Hyperkalaemia	11.75	9.99	271	162509	65739	29723959
Hernia pain	11.75	9.99	10	162770	228	29789470
Vascular insufficiency	11.69	9.99	12	162768	349	29789349
Dermatitis psoriasiform	11.65	9.99	22	162758	1149	29788549
Maternal exposure timing unspecified	11.61	9.99	12	162768	352	29789346
Chronic graft versus host disease	11.50	9.99	4	162776	4115	29785583
Hyperammonaemia	11.43	9.99	8	162772	5512	29784186
Nightmare	11.38	9.99	31	162749	12045	29777653
Asthenia	11.36	9.99	1371	161409	219919	29569779
Abnormal behaviour	11.34	9.99	87	162693	25536	29764162
Hallucination, visual	11.33	9.99	47	162733	16066	29773632
Intellectual disability	11.29	9.99	18	162762	820	29788878
Pyelocaliectasis	11.25	9.99	20	162760	997	29788701
Bronchopulmonary aspergillosis	11.23	9.99	32	162748	12252	29777446
Cystitis haemorrhagic	11.22	9.99	6	162774	4781	29784917
Coccydynia	11.21	9.99	12	162768	367	29789331
Blood insulin increased	11.18	9.99	12	162768	368	29789330
Subdural haematoma	11.18	9.99	59	162721	18913	29770785
Peripheral artery thrombosis	11.17	9.99	32	162748	2200	29787498
Anal atresia	11.15	9.99	11	162769	305	29789393
Delusion	11.13	9.99	31	162749	11958	29777740
Mouth ulceration	11.12	9.99	97	162683	10512	29779186
Otitis media	11.11	9.99	35	162745	2536	29787162
Contusion	11.11	9.99	235	162545	31045	29758653
Joint stiffness	11.10	9.99	88	162692	9273	29780425
Blood iron increased	11.04	9.99	18	162762	836	29788862
Arthropod bite	11.03	9.99	33	162747	2325	29787373
Myocardial infarction	11.02	9.99	564	162216	125061	29664637
Anaphylactic shock	11.01	9.99	39	162741	13954	29775744
Cerebral infarction	11.00	9.99	91	162689	26282	29763416
Fistula	10.98	9.99	56	162724	5066	29784632
Intervertebral disc degeneration	10.98	9.99	57	162723	5194	29784504
Cytomegalovirus viraemia	10.97	9.99	9	162771	5720	29783978
Rhinorrhoea	10.95	9.99	166	162614	20588	29769110
Congenital anomaly	10.95	9.99	23	162757	1299	29788399
Infected bite	10.94	9.99	11	162769	312	29789386
Hepatitis C	10.93	9.99	36	162744	13169	29776529
Infection	10.92	9.99	524	162256	77550	29712148
Palindromic rheumatism	10.92	9.99	9	162771	196	29789502
Microphthalmos	10.92	9.99	9	162771	196	29789502
Hydrocele	10.91	9.99	30	162750	2014	29787684
Lung hernia	10.90	9.99	5	162775	35	29789663
Lung neoplasm malignant	10.87	9.99	128	162652	15004	29774694
Injection site erythema	10.83	9.99	119	162661	13715	29775983
Metabolic acidosis	10.81	9.99	141	162639	37320	29752378
Joint instability	10.80	9.99	12	162768	383	29789315
Diverticulum	10.73	9.99	68	162712	6665	29783033
Blood iron decreased	10.73	9.99	47	162733	3993	29785705
Hepatitis fulminant	10.71	9.99	4	162776	3937	29785761
Steatorrhoea	10.68	9.99	16	162764	690	29789008
Migraine	10.67	9.99	112	162668	12762	29776936
Injection site swelling	10.67	9.99	83	162697	8697	29781001
Pulmonary alveolar haemorrhage	10.66	9.99	12	162768	6569	29783129
Plagiocephaly	10.63	9.99	11	162769	323	29789375
Spinal operation	10.62	9.99	32	162748	2264	29787434
Blood pressure diastolic decreased	10.61	9.99	64	162716	6167	29783531
Excessive cerumen production	10.60	9.99	10	162770	262	29789436
Exostosis	10.59	9.99	42	162738	3413	29786285
Gangrene neonatal	10.58	9.99	9	162771	205	29789493
Electrocardiogram QRS complex prolonged	10.56	9.99	5	162775	4272	29785426
Neonatal seizure	10.49	9.99	13	162767	467	29789231
Erythema multiforme	10.47	9.99	17	162763	7968	29781730
Hypertransaminasaemia	10.46	9.99	4	162776	3881	29785817
Graft versus host disease	10.38	9.99	25	162755	10125	29779573
Tubulointerstitial nephritis	10.34	9.99	56	162724	17835	29771863
Blister infected	10.34	9.99	11	162769	334	29789364
Energy increased	10.34	9.99	22	162758	1254	29788444
Nocardiosis	10.28	9.99	3	162777	3452	29786246
Microcephaly	10.19	9.99	15	162765	637	29789061
Malignant neoplasm progression	10.17	9.99	307	162473	71980	29717718
Congenital diaphragmatic hernia	10.15	9.99	9	162771	217	29789481
Folate deficiency	10.10	9.99	19	162761	990	29788708
Drug withdrawal syndrome neonatal	10.06	9.99	39	162741	3136	29786562
Umbilical hernia	10.04	9.99	43	162737	3618	29786080
Foetal heart rate deceleration abnormality	10.02	9.99	12	162768	416	29789282

Pharmacologic Action:

Source	Code	Description
ATC	A11GA01	ALIMENTARY TRACT AND METABOLISM VITAMINS ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS Ascorbic acid (vitamin C), plain
ATC	A11GB01	ALIMENTARY TRACT AND METABOLISM VITAMINS ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS Ascorbic acid (vitamin C), combinations
ATC	G01AD03	GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Organic acids
ATC	S01XA15	SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals
FDA CS	M0001797	Ascorbic Acid
MeSH PA	D000975	Antioxidants
MeSH PA	D018977	Micronutrients
MeSH PA	D020011	Protective Agents
MeSH PA	D014815	Vitamins
FDA EPC	N0000193618	Vitamin C
CHEBI has role	CHEBI:21241	vitaminum c
CHEBI has role	CHEBI:23354	coenzymes
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:27314	water-soluble vitamins
CHEBI has role	CHEBI:64577	improving agents
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:77962	food antioxidants
CHEBI has role	CHEBI:77746	h. sapiens metabolites
CHEBI has role	CHEBI:83056	daphnia magna metabolites
CHEBI has role	CHEBI:63247	reductants

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Ascorbic acid deficiency	indication	76169001
Breastfeeding (mother)	indication	413712001
Coronavirus infection	off-label use	186747009
Anuria	contraindication	2472002	DOID:2983
Hypocalcemia	contraindication	5291005
Peptic ulcer	contraindication	13200003	DOID:750
Hyperkalemia	contraindication	14140009
Severe chronic ulcerative colitis	contraindication	14311001
Constipation	contraindication	14760008	DOID:2089
Operation on stomach	contraindication	16453004
Primary hyperoxaluria	contraindication	17901006	DOID:2977
Hypocupremia	contraindication	19577007
Hyperphosphatemia	contraindication	20165001	DOID:0050459
Sunburn	contraindication	23346002
Acute vomiting	contraindication	23971007
Multiple sclerosis	contraindication	24700007	DOID:2377
Gastroenteritis	contraindication	25374005	DOID:2326
Acute tuberculosis	contraindication	25629007
Hypervitaminosis D	contraindication	27712000	DOID:9971
Complete atrioventricular block	contraindication	27885002
Toxic megacolon	contraindication	28536002	DOID:1770
Dental fluorosis	contraindication	30265004
Sarcoidosis	contraindication	31541009	DOID:11335
Dehydration	contraindication	34095006
Hypertensive disorder	contraindication	38341003	DOID:10763
Hemosiderosis	contraindication	39011001	DOID:12119
Gastrointestinal ulcer	contraindication	40845000
Toxic colitis	contraindication	42359007
Hypokalemia	contraindication	43339004
Gastrointestinal perforation	contraindication	51875005
Gastrectomy	contraindication	53442002
Systemic lupus erythematosus	contraindication	55464009	DOID:9074
Hyperlipidemia	contraindication	55822004	DOID:1168
Congenital myotonia, autosomal dominant form	contraindication	57938005
Acute nephropathy	contraindication	58574008
Leber's optic atrophy	contraindication	58610003	DOID:705
Hemolytic anemia	contraindication	61261009	DOID:583
Allergic rhinitis	contraindication	61582004
Hypervitaminosis A	contraindication	64559002	DOID:9972
Ulcerative colitis	contraindication	64766004	DOID:8577
Blood coagulation disorder	contraindication	64779008	DOID:1247
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Rheumatoid arthritis	contraindication	69896004	DOID:7148
Diabetes mellitus	contraindication	73211009	DOID:9351
Hyperchloremia	contraindication	74450001
Third degree burn injury	contraindication	80247002
Intestinal obstruction	contraindication	81060008	DOID:8437
Atrophic gastritis	contraindication	84568007	DOID:8929
Human immunodeficiency virus infection	contraindication	86406008	DOID:526
Wilson's disease	contraindication	88518009
Hyponatremia	contraindication	89627008
Kidney disease	contraindication	90708001	DOID:557
Leukemia, disease	contraindication	93143009	DOID:1240
Kidney stone	contraindication	95570007
Anemia due to enzyme deficiency	contraindication	111577008
Gastrointestinal obstruction	contraindication	126765001
Hb SS disease	contraindication	127040003	DOID:10923
Seizure disorder	contraindication	128613002
Osteolysis	contraindication	203522001
Disease of liver	contraindication	235856003	DOID:409
Hyporeninemic hypoaldosteronism	contraindication	236464008
Esophageal dysmotility	contraindication	266434009	DOID:9192
Familial hyperkalemic periodic paralysis	contraindication	304737009	DOID:14451
Gastric retention	contraindication	307227006
Arteriosclerosis obliterans	contraindication	361133006	DOID:5160
At risk for aspiration	contraindication	371736008
Diverticular disease	contraindication	397881000
Hemochromatosis	contraindication	399187006	DOID:2352
Denuded skin	contraindication	418242004
Severe dehydration	contraindication	450316000
Acute exacerbation of asthma	contraindication	708038006
Vitamin K Deficiency Induced Hypoprothrombinemia	contraindication
Malabsorption States	contraindication
Repeated Blood Transfusions	contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.02	acidic
pKa2	9.62	acidic
pKa3	11.85	acidic
pKa4	12.53	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Exclusivity date	Description
4.7GM;100GM;1.015GM;5.9GM;2.691GM;7.5GM	PEG-3350, SODIUM SULFATE, SODIUM CHLORIDE, POTASSIUM CHLORIDE, SODIUM ASCORBATE AND ASCORBIC ACID	NOVEL LABS INC	A090145	Jan. 25, 2012	RX	FOR SOLUTION	ORAL	Feb. 27, 2021	PATENT CHALLENGE
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM	PLENVU	SALIX	N209381	May 4, 2018	RX	FOR SOLUTION	ORAL	May 4, 2021	NEW PRODUCT
25,000MG/50ML (500MG/ML)	ASCOR	MCGUFF	N209112	Oct. 2, 2017	RX	SOLUTION	INTRAVENOUS	Oct. 2, 2024	FOR TREATMENT OF SCURVY IN ADULT AND PEDIATRIC PATIENTS AGE 5 MONTHS AND OLDER FOR WHOM ORAL ADMINISTRATION IS NOT POSSIBLE, INSUFFICIENT OR CONTRAINDICATED

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Solute carrier family 23 member 1	Unclassified	Q9UHI7	S23A1_HUMAN					WOMBAT-PK
Solute carrier family 23 member 2	Transporter	Q9UGH3	S23A2_HUMAN					WOMBAT-PK
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Enzyme	Q02809	PLOD1_HUMAN					WOMBAT-PK
Prolyl 4-hydroxylase subunit alpha-1	Enzyme	P13674	P4HA1_HUMAN					WOMBAT-PK
Tyrosinase	Enzyme	P14679	TYRO_HUMAN		IC50	4.49		CHEMBL
Pancreatic alpha-amylase	Unclassified		AMYP_RAT		IC50	4.58		CHEMBL

External reference:

ID	Source
PQ6CK8PD0R	UNII
4017646	VUID
N0000146025	NUI
D00018	KEGG_DRUG
5743-28-2	SECONDARY_CAS_RN
4017471	VANDF
4017472	VANDF
4017646	VANDF
4021716	VANDF
4026966	VANDF
C0003968	UMLSCUI
CHEBI:29073	CHEBI
ASC	PDB_CHEM_ID
CHEMBL196	ChEMBL_ID
CHEMBL2146095	ChEMBL_ID
DB00126	DRUGBANK_ID
DB14483	DRUGBANK_ID
CHEMBL591665	ChEMBL_ID
D001205	MESH_DESCRIPTOR_UI
54670067	PUBCHEM_CID
372	INN_ID
C069207	MESH_SUPPLEMENTAL_RECORD_UI
4781	IUPHAR_LIGAND_ID
174	INN_ID
DB14482	DRUGBANK_ID
1151	RXNORM
1132	MMSL
32646	MMSL
4221	MMSL
5471	MMSL
5687	MMSL
6032	MMSL
72299	MMSL
NOCODE	MMSL
d00426	MMSL
001010	NDDF
001011	NDDF
001012	NDDF
126230002	SNOMEDCT_US
126231003	SNOMEDCT_US
43706004	SNOMEDCT_US
46123006	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ferralet 90	HUMAN PRESCRIPTION DRUG LABEL	5	0178-0089	TABLET, FILM COATED	120 mg	ORAL	unapproved drug other	17 sections
NataFort	HUMAN PRESCRIPTION DRUG LABEL	10	0178-0716	TABLET	120 mg	ORAL	Unapproved drug other	12 sections
CitraNatal Bloom	HUMAN PRESCRIPTION DRUG LABEL	6	0178-0813	TABLET, FILM COATED	138 mg	ORAL	unapproved drug other	15 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	120 mg	ORAL	unapproved drug other	11 sections
CitraNatal 90 DHA	HUMAN OTC DRUG LABEL	14	0178-0829	TABLET	120 mg	ORAL	Unapproved drug other	11 sections
CitraNatal Rx	HUMAN PRESCRIPTION DRUG LABEL	13	0178-0858	TABLET	120 mg	ORAL	Unapproved drug other	12 sections
CitraNatal Rx	HUMAN PRESCRIPTION DRUG LABEL	14	0178-0859	TABLET	120 mg	ORAL	Unapproved drug other	9 sections
CitraNatal DHA	HUMAN OTC DRUG LABEL	14	0178-0898	TABLET	120 mg	ORAL	Unapproved drug other	11 sections
Antiflu Kids	HUMAN OTC DRUG LABEL	3	0280-0046	POWDER, FOR SOLUTION	50 mg	ORAL	Export only	2 sections
VitafolOne	HUMAN PRESCRIPTION DRUG LABEL	16	0642-0070	CAPSULE, GELATIN COATED	30 mg	ORAL	unapproved drug other	7 sections
Vitafol Caplet	HUMAN PRESCRIPTION DRUG LABEL	12	0642-0072	CAPSULE	60 mg	ORAL	UNULLPPROVED DRUG OTHER	13 sections
Select OB	HUMAN PRESCRIPTION DRUG LABEL	15	0642-0077	TABLET, CHEWABLE	60 mg	ORAL	UNULLPPROVED DRUG OTHER	14 sections
Vitafol OB Caplet	HUMAN PRESCRIPTION DRUG LABEL	15	0642-0079	TABLET	70 mg	ORAL	Unapproved drug other	14 sections
Vitafol Plus	HUMAN PRESCRIPTION DRUG LABEL	17	0642-0092	CAPSULE, LIQUID FILLED	12 mg	ORAL	UNULLPPROVED DRUG OTHER	13 sections
Vitafol Ultra	HUMAN PRESCRIPTION DRUG LABEL	17	0642-0093	CAPSULE, LIQUID FILLED	30 mg	ORAL	UNULLPPROVED DRUG OTHER	13 sections
Select OB	HUMAN PRESCRIPTION DRUG LABEL	15	0642-0120	TABLET, CHEWABLE	60 mg	ORAL	UNULLPPROVED DRUG OTHER	13 sections
Strovite Forte Caplet	HUMAN PRESCRIPTION DRUG LABEL	19	0642-0204	TABLET, COATED	500 mg	ORAL	UNULLPPROVED DRUG OTHER	15 sections
Strovite One Caplets	HUMAN PRESCRIPTION DRUG LABEL	20	0642-0207	TABLET	300 mg	ORAL	UNULLPPROVED DRUG OTHER	14 sections
Reaphirm Plant Source DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0642-3010	CAPSULE, GELATIN COATED	30 mg	ORAL	unapproved drug other	7 sections
Vitafol Fe Plus	HUMAN PRESCRIPTION DRUG LABEL	17	0642-7473	CAPSULE, LIQUID FILLED	60 mg	ORAL	UNULLPPROVED DRUG OTHER	14 sections
Marnatal F	HUMAN PRESCRIPTION DRUG LABEL	13	0682-1570	CAPSULE	100 mg	ORAL	UNULLPPROVED DRUG OTHER	4 sections
BACMIN	HUMAN PRESCRIPTION DRUG LABEL	19	0682-3001	TABLET, COATED	500 mg	ORAL	UNULLPPROVED DRUG OTHER	10 sections
O-Cal Prenatal Vitamin	HUMAN PRESCRIPTION DRUG LABEL	16	0813-0202	TABLET	70 mg	ORAL	UNULLPPROVED DRUG OTHER	6 sections
Acetaminophen, Ascorbic acid, Chlorpheniramine Maleate	HUMAN OTC DRUG LABEL	3	10267-2949	POWDER, FOR SOLUTION	50 mg	ORAL	Export only	1 sections
Dialyvite Supreme D	HUMAN PRESCRIPTION DRUG LABEL	13	10542-009	TABLET, COATED	100 mg	ORAL	Unapproved drug other	7 sections
Dialyvite	HUMAN PRESCRIPTION DRUG LABEL	9	10542-010	TABLET, COATED	100 mg	ORAL	Unapproved drug other	7 sections
Dialyvite 5000	HUMAN PRESCRIPTION DRUG LABEL	12	10542-011	TABLET, COATED	100 mg	ORAL	Unapproved drug other	7 sections
Dialyvite with Zinc	HUMAN PRESCRIPTION DRUG LABEL	10	10542-012	TABLET, COATED	100 mg	ORAL	Unapproved drug other	7 sections
Dialyvite 3000	HUMAN PRESCRIPTION DRUG LABEL	12	10542-014	TABLET, COATED	100 mg	ORAL	Unapproved drug other	7 sections
PRENULLTAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	10544-549	TABLET, FILM COATED	120 mg	ORAL	unapproved drug other	8 sections