Stem definition | Drug id | CAS RN |
---|---|---|
4072 | 50-81-7 |
Dose | Unit | Route |
---|---|---|
0.20 | g | O |
0.20 | g | P |
0.25 | g | V |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 0 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 333 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 25 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 567.77 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.35 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.05 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.26 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 11.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
None | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 884.30 | 9.88 | 71 | 368353 | 145849 | 46171789 |
Rheumatoid arthritis | 825.58 | 9.88 | 3915 | 364509 | 236300 | 46081338 |
Pemphigus | 710.56 | 9.88 | 1279 | 367145 | 43995 | 46273643 |
Systemic lupus erythematosus | 586.07 | 9.88 | 1467 | 366957 | 63713 | 46253925 |
Toxicity to various agents | 579.44 | 9.88 | 492 | 367932 | 211274 | 46106364 |
Glossodynia | 476.06 | 9.88 | 1070 | 367354 | 43303 | 46274335 |
Pain | 368.51 | 9.88 | 5537 | 362887 | 471411 | 45846227 |
Death | 359.14 | 9.88 | 1398 | 367026 | 334150 | 45983488 |
Drug abuse | 354.61 | 9.88 | 42 | 368382 | 63366 | 46254272 |
Hand deformity | 345.72 | 9.88 | 811 | 367613 | 33763 | 46283875 |
Drug interaction | 338.30 | 9.88 | 683 | 367741 | 202411 | 46115227 |
Arthropathy | 303.45 | 9.88 | 1399 | 367025 | 83301 | 46234337 |
Alopecia | 303.12 | 9.88 | 2257 | 366167 | 160157 | 46157481 |
Joint swelling | 296.55 | 9.88 | 2284 | 366140 | 163789 | 46153849 |
Abdominal discomfort | 295.43 | 9.88 | 2124 | 366300 | 149041 | 46168597 |
Maternal exposure during pregnancy | 295.28 | 9.88 | 1592 | 366832 | 100957 | 46216681 |
Intentional overdose | 287.92 | 9.88 | 78 | 368346 | 64866 | 46252772 |
Infusion related reaction | 248.54 | 9.88 | 1506 | 366918 | 99702 | 46217936 |
Arthralgia | 223.51 | 9.88 | 4078 | 364346 | 360525 | 45957113 |
Wound | 211.68 | 9.88 | 781 | 367643 | 42021 | 46275617 |
Suicide attempt | 207.60 | 9.88 | 87 | 368337 | 54949 | 46262689 |
Overdose | 204.18 | 9.88 | 305 | 368119 | 101674 | 46215964 |
Cardiac arrest | 180.35 | 9.88 | 271 | 368153 | 90128 | 46227510 |
Nasopharyngitis | 180.09 | 9.88 | 1933 | 366491 | 152065 | 46165573 |
Exposure during pregnancy | 174.26 | 9.88 | 1454 | 366970 | 106758 | 46210880 |
Drug hypersensitivity | 168.41 | 9.88 | 1179 | 367245 | 242646 | 46074992 |
Contraindicated product administered | 165.12 | 9.88 | 1139 | 367285 | 78808 | 46238830 |
Febrile neutropenia | 161.84 | 9.88 | 313 | 368111 | 94314 | 46223324 |
Acute kidney injury | 159.20 | 9.88 | 1148 | 367276 | 234707 | 46082931 |
Anti-cyclic citrullinated peptide antibody positive | 157.54 | 9.88 | 417 | 368007 | 18728 | 46298910 |
Synovitis | 155.71 | 9.88 | 918 | 367506 | 60157 | 46257481 |
Pericarditis | 141.20 | 9.88 | 463 | 367961 | 23464 | 46294174 |
Hip arthroplasty | 140.49 | 9.88 | 386 | 368038 | 17726 | 46299912 |
Swelling | 133.66 | 9.88 | 1537 | 366887 | 122974 | 46194664 |
Rheumatoid factor positive | 130.82 | 9.88 | 407 | 368017 | 20054 | 46297584 |
Knee arthroplasty | 123.06 | 9.88 | 439 | 367985 | 23226 | 46294412 |
Cardiac failure | 121.19 | 9.88 | 283 | 368141 | 79665 | 46237973 |
Lactic acidosis | 119.45 | 9.88 | 59 | 368365 | 33850 | 46283788 |
Sinusitis | 115.22 | 9.88 | 1546 | 366878 | 128222 | 46189416 |
Device expulsion | 113.12 | 9.88 | 38 | 368386 | 27504 | 46290134 |
Red blood cell sedimentation rate abnormal | 110.99 | 9.88 | 296 | 368128 | 13353 | 46304285 |
Depressed level of consciousness | 107.62 | 9.88 | 130 | 368294 | 47439 | 46270199 |
Injection site erythema | 107.21 | 9.88 | 976 | 367448 | 73451 | 46244187 |
Sickle cell anaemia with crisis | 104.85 | 9.88 | 143 | 368281 | 3849 | 46313789 |
Cardio-respiratory arrest | 101.50 | 9.88 | 199 | 368225 | 59670 | 46257968 |
Discomfort | 100.54 | 9.88 | 672 | 367752 | 45998 | 46271640 |
Neutropenia | 99.44 | 9.88 | 691 | 367733 | 142513 | 46175125 |
Immunodeficiency | 99.36 | 9.88 | 277 | 368147 | 12829 | 46304809 |
Drug reaction with eosinophilia and systemic symptoms | 98.78 | 9.88 | 55 | 368369 | 29493 | 46288145 |
C-reactive protein abnormal | 98.41 | 9.88 | 380 | 368044 | 20890 | 46296748 |
Respiratory arrest | 97.99 | 9.88 | 74 | 368350 | 33742 | 46283896 |
Sopor | 97.44 | 9.88 | 19 | 368405 | 19809 | 46297829 |
Pregnancy | 94.69 | 9.88 | 445 | 367979 | 26692 | 46290946 |
Malignant neoplasm progression | 94.30 | 9.88 | 235 | 368189 | 64691 | 46252947 |
Lower respiratory tract infection | 93.87 | 9.88 | 750 | 367674 | 54339 | 46263299 |
Product use issue | 93.45 | 9.88 | 1150 | 367274 | 93494 | 46224144 |
Intentional self-injury | 93.07 | 9.88 | 37 | 368387 | 24129 | 46293509 |
Electrocardiogram QT prolonged | 91.94 | 9.88 | 165 | 368259 | 51160 | 46266478 |
Fatigue | 90.17 | 9.88 | 5757 | 362667 | 602940 | 45714698 |
Musculoskeletal stiffness | 89.24 | 9.88 | 1173 | 367251 | 96820 | 46220818 |
Arthritis | 89.09 | 9.88 | 968 | 367456 | 76348 | 46241290 |
Confusional state | 86.51 | 9.88 | 825 | 367599 | 159067 | 46158571 |
Rhabdomyolysis | 86.12 | 9.88 | 123 | 368301 | 41786 | 46275852 |
Injection site pain | 85.97 | 9.88 | 1254 | 367170 | 105898 | 46211740 |
Bradycardia | 84.31 | 9.88 | 256 | 368168 | 66042 | 46251596 |
Renal failure | 83.92 | 9.88 | 538 | 367886 | 113056 | 46204582 |
Osteoarthritis | 83.62 | 9.88 | 802 | 367622 | 61223 | 46256415 |
Hyponatraemia | 81.63 | 9.88 | 467 | 367957 | 100865 | 46216773 |
Injection site pruritus | 77.78 | 9.88 | 559 | 367865 | 39184 | 46278454 |
Disease progression | 75.58 | 9.88 | 417 | 368007 | 90883 | 46226755 |
Blood pressure fluctuation | 74.58 | 9.88 | 453 | 367971 | 29995 | 46287643 |
Femur fracture | 72.76 | 9.88 | 521 | 367903 | 36476 | 46281162 |
Injection site reaction | 72.76 | 9.88 | 635 | 367789 | 47214 | 46270424 |
Dyspnoea | 72.44 | 9.88 | 3329 | 365095 | 512219 | 45805419 |
Injection site swelling | 70.32 | 9.88 | 552 | 367872 | 39775 | 46277863 |
Bursitis | 69.68 | 9.88 | 326 | 368098 | 19516 | 46298122 |
Abortion spontaneous | 68.34 | 9.88 | 583 | 367841 | 43063 | 46274575 |
Psoriatic arthropathy | 67.93 | 9.88 | 506 | 367918 | 35873 | 46281765 |
Temperature regulation disorder | 67.41 | 9.88 | 106 | 368318 | 3254 | 46314384 |
Agitation | 66.92 | 9.88 | 219 | 368205 | 55196 | 46262442 |
Hypoglycaemia | 66.88 | 9.88 | 213 | 368211 | 54136 | 46263502 |
Hepatocellular injury | 66.43 | 9.88 | 81 | 368343 | 29441 | 46288197 |
Drug dependence | 65.15 | 9.88 | 38 | 368386 | 19863 | 46297775 |
Hepatic enzyme increased | 64.73 | 9.88 | 955 | 367469 | 80832 | 46236806 |
Hypotension | 63.89 | 9.88 | 1374 | 367050 | 231215 | 46086423 |
Basal cell carcinoma | 63.64 | 9.88 | 325 | 368099 | 20162 | 46297476 |
Tachycardia | 63.22 | 9.88 | 493 | 367931 | 99129 | 46218509 |
Peripheral swelling | 62.27 | 9.88 | 1661 | 366763 | 156410 | 46161228 |
Poisoning | 61.64 | 9.88 | 17 | 368407 | 13977 | 46303661 |
Cholestasis | 61.35 | 9.88 | 73 | 368351 | 26820 | 46290818 |
Metabolic acidosis | 60.59 | 9.88 | 135 | 368289 | 38645 | 46278993 |
Cytomegalovirus infection | 60.32 | 9.88 | 34 | 368390 | 18110 | 46299528 |
Product quality issue | 59.11 | 9.88 | 120 | 368304 | 35528 | 46282110 |
Disability assessment scale score increased | 57.18 | 9.88 | 79 | 368345 | 2153 | 46315485 |
Serotonin syndrome | 57.13 | 9.88 | 64 | 368360 | 24156 | 46293482 |
Hepatic failure | 56.69 | 9.88 | 111 | 368313 | 33305 | 46284333 |
General physical health deterioration | 56.52 | 9.88 | 612 | 367812 | 115157 | 46202481 |
Duodenal ulcer perforation | 56.09 | 9.88 | 171 | 368253 | 8331 | 46309307 |
Osteoporosis | 55.67 | 9.88 | 527 | 367897 | 40081 | 46277557 |
Joint effusion | 55.24 | 9.88 | 214 | 368210 | 11781 | 46305857 |
Delirium | 54.63 | 9.88 | 134 | 368290 | 37094 | 46280544 |
Renal impairment | 54.52 | 9.88 | 353 | 368071 | 74019 | 46243619 |
Drug resistance | 52.95 | 9.88 | 36 | 368388 | 17332 | 46300306 |
Helicobacter infection | 52.12 | 9.88 | 207 | 368217 | 11529 | 46306109 |
Impaired healing | 51.95 | 9.88 | 480 | 367944 | 36263 | 46281375 |
Drug withdrawal syndrome | 51.81 | 9.88 | 85 | 368339 | 27299 | 46290339 |
Pulmonary arterial hypertension | 51.41 | 9.88 | 78 | 368346 | 25850 | 46291788 |
Multiple organ dysfunction syndrome | 50.97 | 9.88 | 222 | 368202 | 51488 | 46266150 |
Product use in unapproved indication | 50.40 | 9.88 | 462 | 367962 | 89811 | 46227827 |
Therapeutic product effect decreased | 48.94 | 9.88 | 920 | 367504 | 81681 | 46235957 |
Intentional product misuse | 47.88 | 9.88 | 200 | 368224 | 46928 | 46270710 |
Encephalopathy | 47.66 | 9.88 | 123 | 368301 | 33466 | 46284172 |
Poisoning deliberate | 47.55 | 9.88 | 4 | 368420 | 7922 | 46309716 |
Pain in extremity | 47.52 | 9.88 | 2496 | 365928 | 256184 | 46061454 |
Tremor | 47.40 | 9.88 | 635 | 367789 | 115004 | 46202634 |
Disorientation | 47.32 | 9.88 | 142 | 368282 | 36776 | 46280862 |
Coma | 46.92 | 9.88 | 269 | 368155 | 58080 | 46259558 |
Caesarean section | 46.51 | 9.88 | 256 | 368168 | 16347 | 46301291 |
Joint laxity | 46.10 | 9.88 | 69 | 368355 | 2027 | 46315611 |
Sedation | 45.35 | 9.88 | 69 | 368355 | 22841 | 46294797 |
Anaphylactic reaction | 44.81 | 9.88 | 241 | 368183 | 52871 | 46264767 |
Psoriasis | 44.70 | 9.88 | 870 | 367554 | 77734 | 46239904 |
Hepatic function abnormal | 44.40 | 9.88 | 132 | 368292 | 34289 | 46283349 |
Hyperglycaemia | 44.16 | 9.88 | 136 | 368288 | 34935 | 46282703 |
Upper respiratory tract infection | 44.13 | 9.88 | 726 | 367698 | 62830 | 46254808 |
Respiratory failure | 43.60 | 9.88 | 508 | 367916 | 94308 | 46223330 |
Maternal drugs affecting foetus | 43.19 | 9.88 | 118 | 368306 | 5400 | 46312238 |
Thrombocytopenia | 42.95 | 9.88 | 721 | 367703 | 125860 | 46191778 |
Hyperkalaemia | 42.83 | 9.88 | 230 | 368194 | 50479 | 46267159 |
Mydriasis | 42.57 | 9.88 | 15 | 368409 | 10538 | 46307100 |
Diabetic ketoacidosis | 42.00 | 9.88 | 49 | 368375 | 18161 | 46299477 |
Blood pressure diastolic abnormal | 41.91 | 9.88 | 127 | 368297 | 6167 | 46311471 |
Injection site bruising | 41.87 | 9.88 | 448 | 367976 | 35188 | 46282450 |
Hypothermia | 41.71 | 9.88 | 22 | 368402 | 12161 | 46305477 |
Hypoxia | 41.67 | 9.88 | 239 | 368185 | 51599 | 46266039 |
Night sweats | 41.60 | 9.88 | 362 | 368062 | 26888 | 46290750 |
Body temperature increased | 41.53 | 9.88 | 337 | 368087 | 24524 | 46293114 |
Syncope | 40.97 | 9.88 | 581 | 367843 | 104222 | 46213416 |
Food allergy | 40.75 | 9.88 | 134 | 368290 | 6799 | 46310839 |
Extrapyramidal disorder | 40.61 | 9.88 | 19 | 368405 | 11249 | 46306389 |
Palmar-plantar erythrodysaesthesia syndrome | 40.09 | 9.88 | 62 | 368362 | 20389 | 46297249 |
Torsade de pointes | 40.08 | 9.88 | 23 | 368401 | 12131 | 46305507 |
Oropharyngeal pain | 39.86 | 9.88 | 814 | 367610 | 73354 | 46244284 |
Seizure | 39.79 | 9.88 | 707 | 367717 | 122347 | 46195291 |
Hallucination | 39.78 | 9.88 | 231 | 368193 | 49720 | 46267918 |
Nausea | 39.14 | 9.88 | 4791 | 363633 | 682663 | 45634975 |
Osteonecrosis of jaw | 38.79 | 9.88 | 140 | 368284 | 34262 | 46283376 |
Live birth | 38.71 | 9.88 | 173 | 368251 | 10157 | 46307481 |
Schizophrenia | 38.51 | 9.88 | 10 | 368414 | 8558 | 46309080 |
Localised infection | 38.35 | 9.88 | 320 | 368104 | 23481 | 46294157 |
Weight increased | 38.05 | 9.88 | 1624 | 366800 | 162849 | 46154789 |
Injection site rash | 37.92 | 9.88 | 234 | 368190 | 15579 | 46302059 |
Neck deformity | 37.90 | 9.88 | 59 | 368365 | 1795 | 46315843 |
No adverse event | 37.49 | 9.88 | 141 | 368283 | 34090 | 46283548 |
Pre-eclampsia | 37.12 | 9.88 | 143 | 368281 | 7851 | 46309787 |
Acute hepatic failure | 36.85 | 9.88 | 37 | 368387 | 14684 | 46302954 |
Altered state of consciousness | 36.70 | 9.88 | 81 | 368343 | 23267 | 46294371 |
Shock | 36.68 | 9.88 | 73 | 368351 | 21772 | 46295866 |
Ejection fraction decreased | 36.50 | 9.88 | 53 | 368371 | 17884 | 46299754 |
Leukopenia | 36.33 | 9.88 | 354 | 368070 | 67989 | 46249649 |
Foot deformity | 35.58 | 9.88 | 226 | 368198 | 15199 | 46302439 |
Anxiety | 35.55 | 9.88 | 1129 | 367295 | 180828 | 46136810 |
Somnolence | 35.38 | 9.88 | 952 | 367472 | 155569 | 46162069 |
Gamma-glutamyltransferase increased | 35.24 | 9.88 | 130 | 368294 | 31610 | 46286028 |
Oral herpes | 35.23 | 9.88 | 268 | 368156 | 19122 | 46298516 |
Gestational diabetes | 35.06 | 9.88 | 131 | 368293 | 7088 | 46310550 |
Disseminated intravascular coagulation | 35.02 | 9.88 | 60 | 368364 | 18945 | 46298693 |
Abnormal behaviour | 34.81 | 9.88 | 71 | 368353 | 20987 | 46296651 |
Loss of personal independence in daily activities | 34.59 | 9.88 | 639 | 367785 | 56544 | 46261094 |
Blood creatine phosphokinase increased | 34.56 | 9.88 | 108 | 368316 | 27616 | 46290022 |
Premature labour | 34.23 | 9.88 | 178 | 368246 | 11121 | 46306517 |
Ear pain | 34.00 | 9.88 | 294 | 368130 | 21798 | 46295840 |
Coeliac disease | 33.99 | 9.88 | 129 | 368295 | 7032 | 46310606 |
Influenza | 33.96 | 9.88 | 934 | 367490 | 88336 | 46229302 |
Suicidal ideation | 33.92 | 9.88 | 283 | 368141 | 56099 | 46261539 |
Psychotic disorder | 33.52 | 9.88 | 81 | 368343 | 22540 | 46295098 |
Contusion | 33.18 | 9.88 | 915 | 367509 | 86572 | 46231066 |
Juvenile idiopathic arthritis | 32.98 | 9.88 | 89 | 368335 | 4043 | 46313595 |
Red blood cell sedimentation rate increased | 32.85 | 9.88 | 300 | 368124 | 22589 | 46295049 |
Bronchitis | 32.82 | 9.88 | 1081 | 367343 | 104898 | 46212740 |
Off label use | 32.77 | 9.88 | 2567 | 365857 | 377274 | 45940364 |
Neuroleptic malignant syndrome | 32.66 | 9.88 | 24 | 368400 | 11098 | 46306540 |
Limb deformity | 32.63 | 9.88 | 81 | 368343 | 3495 | 46314143 |
Muscle spasticity | 32.45 | 9.88 | 177 | 368247 | 11263 | 46306375 |
Metastases to bone | 32.36 | 9.88 | 55 | 368369 | 17421 | 46300217 |
Rheumatoid nodule | 32.26 | 9.88 | 149 | 368275 | 8871 | 46308767 |
Anaphylactic shock | 32.14 | 9.88 | 70 | 368354 | 20204 | 46297434 |
Herpes zoster | 32.01 | 9.88 | 731 | 367693 | 67141 | 46250497 |
Blood pressure systolic abnormal | 31.86 | 9.88 | 106 | 368318 | 5411 | 46312227 |
Metastases to liver | 31.56 | 9.88 | 67 | 368357 | 19518 | 46298120 |
Loss of consciousness | 31.55 | 9.88 | 633 | 367791 | 107605 | 46210033 |
Dizziness | 31.34 | 9.88 | 2288 | 366136 | 338126 | 45979512 |
Cellulitis | 30.99 | 9.88 | 750 | 367674 | 69538 | 46248100 |
Drug level increased | 30.64 | 9.88 | 62 | 368362 | 18379 | 46299259 |
Blood bilirubin increased | 30.59 | 9.88 | 152 | 368272 | 34032 | 46283606 |
Transplant rejection | 30.46 | 9.88 | 19 | 368405 | 9577 | 46308061 |
Multiple fractures | 30.43 | 9.88 | 105 | 368319 | 5462 | 46312176 |
Therapeutic response decreased | 30.37 | 9.88 | 494 | 367930 | 42651 | 46274987 |
Ventricular tachycardia | 29.97 | 9.88 | 55 | 368369 | 16912 | 46300726 |
Cystitis | 29.86 | 9.88 | 484 | 367940 | 41757 | 46275881 |
Carpal tunnel syndrome | 29.83 | 9.88 | 221 | 368203 | 15638 | 46302000 |
Pyrexia | 29.64 | 9.88 | 2360 | 366064 | 346442 | 45971196 |
Akathisia | 29.39 | 9.88 | 12 | 368412 | 7702 | 46309936 |
Grip strength decreased | 29.20 | 9.88 | 140 | 368284 | 8466 | 46309172 |
Intramedullary rod insertion | 29.17 | 9.88 | 57 | 368367 | 2086 | 46315552 |
Nodule | 29.09 | 9.88 | 217 | 368207 | 15388 | 46302250 |
Cardiac failure congestive | 29.06 | 9.88 | 529 | 367895 | 91221 | 46226417 |
Toxic skin eruption | 28.92 | 9.88 | 33 | 368391 | 12354 | 46305284 |
Posterior reversible encephalopathy syndrome | 28.64 | 9.88 | 47 | 368377 | 15094 | 46302544 |
Arthritis infective | 28.44 | 9.88 | 97 | 368327 | 5016 | 46312622 |
Neurotoxicity | 28.43 | 9.88 | 40 | 368384 | 13677 | 46303961 |
Inappropriate antidiuretic hormone secretion | 28.37 | 9.88 | 42 | 368382 | 14060 | 46303578 |
Skin cancer | 28.13 | 9.88 | 141 | 368283 | 8682 | 46308956 |
Accidental overdose | 28.07 | 9.88 | 74 | 368350 | 19992 | 46297646 |
Agranulocytosis | 27.95 | 9.88 | 86 | 368338 | 22099 | 46295539 |
Hypokalaemia | 27.73 | 9.88 | 508 | 367916 | 87516 | 46230122 |
Angioedema | 27.68 | 9.88 | 189 | 368235 | 39153 | 46278485 |
Hypersensitivity | 27.66 | 9.88 | 1451 | 366973 | 148870 | 46168768 |
Premature delivery | 27.60 | 9.88 | 281 | 368143 | 21788 | 46295850 |
Ventricular septal defect | 27.42 | 9.88 | 82 | 368342 | 3952 | 46313686 |
Smear cervix abnormal | 27.33 | 9.88 | 61 | 368363 | 2455 | 46315183 |
Vomiting | 27.26 | 9.88 | 3143 | 365281 | 449651 | 45867987 |
Febrile bone marrow aplasia | 27.26 | 9.88 | 10 | 368414 | 6852 | 46310786 |
Blood creatinine increased | 26.95 | 9.88 | 432 | 367992 | 75971 | 46241667 |
Malignant melanoma | 26.82 | 9.88 | 155 | 368269 | 10079 | 46307559 |
Small for dates baby | 26.71 | 9.88 | 76 | 368348 | 3561 | 46314077 |
Acute generalised exanthematous pustulosis | 26.71 | 9.88 | 21 | 368403 | 9384 | 46308254 |
Aggression | 26.69 | 9.88 | 91 | 368333 | 22653 | 46294985 |
Fibromyalgia | 26.60 | 9.88 | 420 | 368004 | 36043 | 46281595 |
Unresponsive to stimuli | 26.58 | 9.88 | 147 | 368277 | 32027 | 46285611 |
Heart rate decreased | 26.50 | 9.88 | 374 | 368050 | 31349 | 46286289 |
Blood pressure diastolic increased | 26.23 | 9.88 | 105 | 368319 | 5869 | 46311769 |
Blood pressure diastolic decreased | 26.15 | 9.88 | 197 | 368227 | 14014 | 46303624 |
Injection site warmth | 25.95 | 9.88 | 192 | 368232 | 13580 | 46304058 |
Respiratory depression | 25.91 | 9.88 | 32 | 368392 | 11568 | 46306070 |
Anaemia | 25.85 | 9.88 | 1705 | 366719 | 254074 | 46063564 |
Mental status changes | 25.80 | 9.88 | 185 | 368239 | 37903 | 46279735 |
Disturbance in attention | 25.63 | 9.88 | 145 | 368279 | 31415 | 46286223 |
Myocardial infarction | 25.61 | 9.88 | 580 | 367844 | 96948 | 46220690 |
Thrombotic microangiopathy | 25.61 | 9.88 | 17 | 368407 | 8289 | 46309349 |
Neck mass | 25.35 | 9.88 | 70 | 368354 | 3223 | 46314415 |
Foetal exposure during pregnancy | 25.08 | 9.88 | 361 | 368063 | 30386 | 46287252 |
Developmental hip dysplasia | 25.08 | 9.88 | 40 | 368384 | 1243 | 46316395 |
Dysarthria | 24.99 | 9.88 | 183 | 368241 | 37315 | 46280323 |
Bone marrow failure | 24.81 | 9.88 | 135 | 368289 | 29534 | 46288104 |
Gastroenteritis viral | 24.75 | 9.88 | 235 | 368189 | 17884 | 46299754 |
Tuberculosis | 24.68 | 9.88 | 152 | 368272 | 10113 | 46307525 |
Dry eye | 24.34 | 9.88 | 355 | 368069 | 29967 | 46287671 |
Surgery | 24.30 | 9.88 | 340 | 368084 | 28445 | 46289193 |
Musculoskeletal pain | 24.25 | 9.88 | 725 | 367699 | 69403 | 46248235 |
Graft versus host disease | 23.91 | 9.88 | 11 | 368413 | 6577 | 46311061 |
Ischaemic stroke | 23.90 | 9.88 | 61 | 368363 | 16661 | 46300977 |
Bone erosion | 23.44 | 9.88 | 141 | 368283 | 9302 | 46308336 |
Skin ulcer | 23.35 | 9.88 | 373 | 368051 | 32085 | 46285553 |
Status epilepticus | 23.22 | 9.88 | 47 | 368377 | 13932 | 46303706 |
Rash | 23.22 | 9.88 | 3181 | 365243 | 353331 | 45964307 |
Joint stiffness | 23.21 | 9.88 | 321 | 368103 | 26787 | 46290851 |
Synovial cyst | 23.14 | 9.88 | 117 | 368307 | 7229 | 46310409 |
Mania | 23.11 | 9.88 | 31 | 368393 | 10815 | 46306823 |
Polyneuropathy | 23.11 | 9.88 | 35 | 368389 | 11609 | 46306029 |
Acute myeloid leukaemia | 22.98 | 9.88 | 57 | 368367 | 15721 | 46301917 |
Premature rupture of membranes | 22.94 | 9.88 | 82 | 368342 | 4341 | 46313297 |
Face oedema | 22.90 | 9.88 | 76 | 368348 | 19077 | 46298561 |
Multiple sclerosis relapse | 22.89 | 9.88 | 217 | 368207 | 41908 | 46275730 |
Enthesopathy | 22.69 | 9.88 | 85 | 368339 | 4605 | 46313033 |
Cyst | 22.41 | 9.88 | 168 | 368256 | 11932 | 46305706 |
Weight decreased | 22.15 | 9.88 | 1942 | 366482 | 208907 | 46108731 |
Treatment failure | 22.14 | 9.88 | 922 | 367502 | 92165 | 46225473 |
Tenosynovitis stenosans | 22.01 | 9.88 | 48 | 368376 | 1901 | 46315737 |
Restlessness | 21.98 | 9.88 | 115 | 368309 | 25409 | 46292229 |
Postoperative wound infection | 21.92 | 9.88 | 131 | 368293 | 8622 | 46309016 |
Neuropathy peripheral | 21.80 | 9.88 | 548 | 367876 | 90345 | 46227293 |
Dyspnoea exertional | 21.75 | 9.88 | 273 | 368151 | 50016 | 46267622 |
Acute graft versus host disease | 21.72 | 9.88 | 3 | 368421 | 4027 | 46313611 |
Hallucination, auditory | 21.67 | 9.88 | 32 | 368392 | 10724 | 46306914 |
Rash maculo-papular | 21.61 | 9.88 | 130 | 368294 | 27744 | 46289894 |
Foot fracture | 21.54 | 9.88 | 243 | 368181 | 19339 | 46298299 |
Joint destruction | 21.51 | 9.88 | 63 | 368361 | 3001 | 46314637 |
Hiatus hernia | 21.46 | 9.88 | 230 | 368194 | 18072 | 46299566 |
Drug-induced liver injury | 21.45 | 9.88 | 115 | 368309 | 25253 | 46292385 |
Nightmare | 21.15 | 9.88 | 64 | 368360 | 16534 | 46301104 |
Joint range of motion decreased | 21.08 | 9.88 | 197 | 368227 | 14927 | 46302711 |
Cataract | 21.05 | 9.88 | 488 | 367936 | 44927 | 46272711 |
Parkinsonism | 21.03 | 9.88 | 19 | 368405 | 7929 | 46309709 |
Forced expiratory volume decreased | 21.03 | 9.88 | 7 | 368417 | 5097 | 46312541 |
Neoplasm progression | 20.92 | 9.88 | 124 | 368300 | 26559 | 46291079 |
Dyskinesia | 20.83 | 9.88 | 138 | 368286 | 28787 | 46288851 |
Tachypnoea | 20.78 | 9.88 | 52 | 368372 | 14299 | 46303339 |
Inflammation | 20.75 | 9.88 | 518 | 367906 | 48263 | 46269375 |
Ear infection | 20.72 | 9.88 | 275 | 368149 | 22738 | 46294900 |
Brain oedema | 20.69 | 9.88 | 42 | 368382 | 12436 | 46305202 |
Respiratory distress | 20.67 | 9.88 | 157 | 368267 | 31759 | 46285879 |
Diabetes mellitus inadequate control | 20.64 | 9.88 | 46 | 368378 | 13168 | 46304470 |
Cerebral haemorrhage | 20.61 | 9.88 | 135 | 368289 | 28236 | 46289402 |
Jaundice | 20.58 | 9.88 | 138 | 368286 | 28707 | 46288931 |
Fracture delayed union | 20.52 | 9.88 | 50 | 368374 | 2132 | 46315506 |
Aspartate aminotransferase increased | 20.39 | 9.88 | 469 | 367955 | 78231 | 46239407 |
Impaired quality of life | 20.27 | 9.88 | 64 | 368360 | 3178 | 46314460 |
Haemoglobin decreased | 20.26 | 9.88 | 1227 | 367197 | 127722 | 46189916 |
Serum ferritin increased | 20.19 | 9.88 | 89 | 368335 | 5194 | 46312444 |
Wheezing | 20.14 | 9.88 | 298 | 368126 | 53088 | 46264550 |
Immune reconstitution inflammatory syndrome | 20.10 | 9.88 | 10 | 368414 | 5715 | 46311923 |
Device dislocation | 20.05 | 9.88 | 96 | 368328 | 21706 | 46295932 |
Hypomania | 19.95 | 9.88 | 5 | 368419 | 4383 | 46313255 |
Obstructive airways disorder | 19.89 | 9.88 | 48 | 368376 | 13364 | 46304274 |
Eosinophilia | 19.86 | 9.88 | 81 | 368343 | 19136 | 46298502 |
Speech disorder | 19.78 | 9.88 | 186 | 368238 | 35981 | 46281657 |
Skin papilloma | 19.63 | 9.88 | 75 | 368349 | 4101 | 46313537 |
Myalgia | 19.62 | 9.88 | 783 | 367641 | 122305 | 46195333 |
Latent tuberculosis | 19.60 | 9.88 | 46 | 368378 | 1914 | 46315724 |
Swollen joint count increased | 19.46 | 9.88 | 52 | 368372 | 2348 | 46315290 |
Squamous cell carcinoma | 19.45 | 9.88 | 117 | 368307 | 7719 | 46309919 |
Blood pressure systolic increased | 19.30 | 9.88 | 327 | 368097 | 28460 | 46289178 |
Pancreatitis acute | 19.28 | 9.88 | 116 | 368308 | 24756 | 46292882 |
Tenderness | 19.26 | 9.88 | 211 | 368213 | 16670 | 46300968 |
Device use error | 19.20 | 9.88 | 8 | 368416 | 5073 | 46312565 |
Alanine aminotransferase increased | 19.19 | 9.88 | 541 | 367883 | 87910 | 46229728 |
Blood pressure increased | 19.11 | 9.88 | 1201 | 367223 | 125465 | 46192173 |
Bronchospasm | 19.01 | 9.88 | 62 | 368362 | 15645 | 46301993 |
Polyhydramnios | 19.01 | 9.88 | 46 | 368378 | 1953 | 46315685 |
Psychomotor hyperactivity | 18.98 | 9.88 | 29 | 368395 | 9584 | 46308054 |
Cardiogenic shock | 18.92 | 9.88 | 66 | 368358 | 16318 | 46301320 |
Blood iron increased | 18.85 | 9.88 | 36 | 368388 | 1295 | 46316343 |
Fracture | 18.85 | 9.88 | 206 | 368218 | 16265 | 46301373 |
Ventricular fibrillation | 18.80 | 9.88 | 39 | 368385 | 11457 | 46306181 |
Laryngitis | 18.78 | 9.88 | 132 | 368292 | 9184 | 46308454 |
Miosis | 18.74 | 9.88 | 15 | 368409 | 6642 | 46310996 |
Oliguria | 18.70 | 9.88 | 25 | 368399 | 8734 | 46308904 |
Placental disorder | 18.60 | 9.88 | 37 | 368387 | 1372 | 46316266 |
Rheumatic fever | 18.58 | 9.88 | 57 | 368367 | 2786 | 46314852 |
Low turnover osteopathy | 18.52 | 9.88 | 75 | 368349 | 4214 | 46313424 |
Substance abuse | 18.47 | 9.88 | 5 | 368419 | 4162 | 46313476 |
Rotator cuff repair | 18.39 | 9.88 | 38 | 368386 | 1449 | 46316189 |
Transplant dysfunction | 18.30 | 9.88 | 7 | 368417 | 4675 | 46312963 |
Blood alkaline phosphatase increased | 18.28 | 9.88 | 212 | 368212 | 39397 | 46278241 |
Eye infection | 18.24 | 9.88 | 129 | 368295 | 8994 | 46308644 |
Joint noise | 18.20 | 9.88 | 61 | 368363 | 3126 | 46314512 |
Rhinorrhoea | 18.20 | 9.88 | 499 | 367925 | 47166 | 46270472 |
Accidental exposure to product | 18.14 | 9.88 | 95 | 368329 | 20986 | 46296652 |
Ascites | 17.99 | 9.88 | 193 | 368231 | 36391 | 46281247 |
Joint injury | 17.91 | 9.88 | 231 | 368193 | 18978 | 46298660 |
Stress cardiomyopathy | 17.89 | 9.88 | 21 | 368403 | 7763 | 46309875 |
Blood glucose increased | 17.86 | 9.88 | 432 | 367992 | 71581 | 46246057 |
Haematotoxicity | 17.84 | 9.88 | 17 | 368407 | 6916 | 46310722 |
Myoclonus | 17.82 | 9.88 | 56 | 368368 | 14296 | 46303342 |
Haemorrhage | 17.80 | 9.88 | 315 | 368109 | 54554 | 46263084 |
Congenital arterial malformation | 17.78 | 9.88 | 18 | 368406 | 349 | 46317289 |
Tardive dyskinesia | 17.71 | 9.88 | 20 | 368404 | 7523 | 46310115 |
Breast feeding | 17.68 | 9.88 | 28 | 368396 | 865 | 46316773 |
Asphyxia | 17.67 | 9.88 | 10 | 368414 | 5316 | 46312322 |
Catatonia | 17.67 | 9.88 | 4 | 368420 | 3758 | 46313880 |
Myocarditis | 17.66 | 9.88 | 21 | 368403 | 7718 | 46309920 |
Injection site haematoma | 17.63 | 9.88 | 95 | 368329 | 6017 | 46311621 |
Cerebral infarction | 17.58 | 9.88 | 110 | 368314 | 23256 | 46294382 |
Metastases to central nervous system | 17.57 | 9.88 | 39 | 368385 | 11182 | 46306456 |
Plasma cell myeloma | 17.57 | 9.88 | 246 | 368178 | 44232 | 46273406 |
Erythema multiforme | 17.55 | 9.88 | 31 | 368393 | 9673 | 46307965 |
Acute chest syndrome | 17.42 | 9.88 | 22 | 368402 | 548 | 46317090 |
Lupus vasculitis | 17.31 | 9.88 | 20 | 368404 | 453 | 46317185 |
Viral infection | 17.29 | 9.88 | 335 | 368089 | 29900 | 46287738 |
Oedema | 17.28 | 9.88 | 400 | 368024 | 66671 | 46250967 |
Bone density decreased | 17.28 | 9.88 | 134 | 368290 | 9618 | 46308020 |
Hypocalcaemia | 17.23 | 9.88 | 132 | 368292 | 26653 | 46290985 |
Second primary malignancy | 17.11 | 9.88 | 16 | 368408 | 6568 | 46311070 |
Polyarthritis | 17.09 | 9.88 | 99 | 368325 | 6443 | 46311195 |
Bone disorder | 17.06 | 9.88 | 237 | 368187 | 19796 | 46297842 |
Ketoacidosis | 17.06 | 9.88 | 5 | 368419 | 3950 | 46313688 |
Shock haemorrhagic | 17.04 | 9.88 | 26 | 368398 | 8598 | 46309040 |
Haemorrhage intracranial | 16.99 | 9.88 | 48 | 368376 | 12676 | 46304962 |
Muscle rigidity | 16.97 | 9.88 | 33 | 368391 | 9928 | 46307710 |
Melaena | 16.88 | 9.88 | 139 | 368285 | 27633 | 46290005 |
Pleural effusion | 16.83 | 9.88 | 512 | 367912 | 82440 | 46235198 |
Uterine contractions during pregnancy | 16.82 | 9.88 | 21 | 368403 | 517 | 46317121 |
Renal injury | 16.79 | 9.88 | 31 | 368393 | 9510 | 46308128 |
Synovial fluid analysis | 16.77 | 9.88 | 35 | 368389 | 1344 | 46316294 |
Loose body in joint | 16.76 | 9.88 | 30 | 368394 | 1026 | 46316612 |
Foot operation | 16.76 | 9.88 | 78 | 368346 | 4659 | 46312979 |
Immunosuppression | 16.75 | 9.88 | 109 | 368315 | 7391 | 46310247 |
Body tinea | 16.72 | 9.88 | 28 | 368396 | 907 | 46316731 |
Haemophagocytic lymphohistiocytosis | 16.63 | 9.88 | 25 | 368399 | 8317 | 46309321 |
Pathogen resistance | 16.63 | 9.88 | 14 | 368410 | 6046 | 46311592 |
Wrist fracture | 16.62 | 9.88 | 151 | 368273 | 11352 | 46306286 |
Tooth infection | 16.61 | 9.88 | 159 | 368265 | 12127 | 46305511 |
Knee operation | 16.51 | 9.88 | 78 | 368346 | 4688 | 46312950 |
Pharyngitis streptococcal | 16.50 | 9.88 | 119 | 368305 | 8349 | 46309289 |
Gallbladder polyp | 16.46 | 9.88 | 25 | 368399 | 744 | 46316894 |
Wheelchair user | 16.45 | 9.88 | 69 | 368355 | 3939 | 46313699 |
Arrhythmia | 16.26 | 9.88 | 186 | 368238 | 34655 | 46282983 |
Clear cell renal cell carcinoma | 16.24 | 9.88 | 29 | 368395 | 990 | 46316648 |
International normalised ratio increased | 16.23 | 9.88 | 266 | 368158 | 46617 | 46271021 |
Epilepsy | 16.22 | 9.88 | 115 | 368309 | 23623 | 46294015 |
Injection site irritation | 16.21 | 9.88 | 72 | 368352 | 4215 | 46313423 |
Product administration error | 16.21 | 9.88 | 90 | 368334 | 19591 | 46298047 |
Urinary tract infection | 16.16 | 9.88 | 1980 | 366444 | 218286 | 46099352 |
Tumour lysis syndrome | 16.12 | 9.88 | 20 | 368404 | 7216 | 46310422 |
Synovial disorder | 16.12 | 9.88 | 26 | 368398 | 816 | 46316822 |
Anuria | 16.10 | 9.88 | 42 | 368382 | 11389 | 46306249 |
Body height below normal | 16.09 | 9.88 | 41 | 368383 | 1798 | 46315840 |
Metastases to lung | 16.08 | 9.88 | 38 | 368386 | 10658 | 46306980 |
Pulmonary tuberculosis | 16.08 | 9.88 | 77 | 368347 | 4654 | 46312984 |
Injection site haemorrhage | 16.05 | 9.88 | 241 | 368183 | 20468 | 46297170 |
Device difficult to use | 15.94 | 9.88 | 24 | 368400 | 7980 | 46309658 |
Cervical incompetence | 15.88 | 9.88 | 22 | 368402 | 601 | 46317037 |
Pemphigoid | 15.80 | 9.88 | 13 | 368411 | 5678 | 46311960 |
Gestational hypertension | 15.80 | 9.88 | 45 | 368379 | 2110 | 46315528 |
Hallucination, visual | 15.69 | 9.88 | 80 | 368344 | 17793 | 46299845 |
Cestode infection | 15.62 | 9.88 | 15 | 368409 | 272 | 46317366 |
Blood pressure decreased | 15.55 | 9.88 | 338 | 368086 | 56821 | 46260817 |
Neutrophil count decreased | 15.49 | 9.88 | 245 | 368179 | 43181 | 46274457 |
Endodontic procedure | 15.48 | 9.88 | 49 | 368375 | 2436 | 46315202 |
Disability | 15.48 | 9.88 | 135 | 368289 | 10032 | 46307606 |
Cytomegalovirus viraemia | 15.46 | 9.88 | 8 | 368416 | 4470 | 46313168 |
Complication of device insertion | 15.40 | 9.88 | 10 | 368414 | 4934 | 46312704 |
Bronchopulmonary aspergillosis | 15.40 | 9.88 | 22 | 368402 | 7474 | 46310164 |
Acute pulmonary oedema | 15.39 | 9.88 | 24 | 368400 | 7867 | 46309771 |
Hemiparesis | 15.34 | 9.88 | 94 | 368330 | 19975 | 46297663 |
Intervertebral disc degeneration | 15.28 | 9.88 | 166 | 368258 | 13086 | 46304552 |
Exomphalos | 15.21 | 9.88 | 20 | 368404 | 519 | 46317119 |
Cytokine release syndrome | 15.17 | 9.88 | 16 | 368408 | 6207 | 46311431 |
Crystal nephropathy | 15.15 | 9.88 | 25 | 368399 | 800 | 46316838 |
Coagulopathy | 15.02 | 9.88 | 85 | 368339 | 18414 | 46299224 |
Hypomagnesaemia | 14.98 | 9.88 | 108 | 368316 | 22102 | 46295536 |
Pulmonary hypertension | 14.97 | 9.88 | 197 | 368227 | 35796 | 46281842 |
Deafness transitory | 14.93 | 9.88 | 37 | 368387 | 1595 | 46316043 |
Stevens-Johnson syndrome | 14.90 | 9.88 | 115 | 368309 | 23182 | 46294456 |
Withdrawal syndrome | 14.90 | 9.88 | 83 | 368341 | 18051 | 46299587 |
Cyanosis | 14.88 | 9.88 | 70 | 368354 | 15901 | 46301737 |
Limb injury | 14.81 | 9.88 | 223 | 368201 | 18951 | 46298687 |
Atrial septal defect | 14.74 | 9.88 | 93 | 368331 | 6239 | 46311399 |
Sinus tachycardia | 14.74 | 9.88 | 105 | 368319 | 21544 | 46296094 |
Toxic epidermal necrolysis | 14.71 | 9.88 | 109 | 368315 | 22169 | 46295469 |
Decreased appetite | 14.55 | 9.88 | 1324 | 367100 | 192512 | 46125126 |
Aspergillus infection | 14.37 | 9.88 | 20 | 368404 | 6870 | 46310768 |
Infective pulmonary exacerbation of cystic fibrosis | 14.26 | 9.88 | 41 | 368383 | 10766 | 46306872 |
Induced labour | 14.15 | 9.88 | 26 | 368398 | 908 | 46316730 |
Atrioventricular block complete | 14.12 | 9.88 | 24 | 368400 | 7603 | 46310035 |
Bradyphrenia | 14.11 | 9.88 | 17 | 368407 | 6213 | 46311425 |
Drug ineffective for unapproved indication | 14.10 | 9.88 | 74 | 368350 | 16339 | 46301299 |
Gastrointestinal pain | 14.09 | 9.88 | 104 | 368320 | 7351 | 46310287 |
Red blood cell count decreased | 14.04 | 9.88 | 347 | 368077 | 32276 | 46285362 |
Pulmonary embolism | 13.98 | 9.88 | 707 | 367717 | 107878 | 46209760 |
Injection site urticaria | 13.85 | 9.88 | 150 | 368274 | 11817 | 46305821 |
Glycosylated haemoglobin increased | 13.81 | 9.88 | 42 | 368382 | 10834 | 46306804 |
Asthma | 13.80 | 9.88 | 586 | 367838 | 90956 | 46226682 |
Diverticulitis | 13.80 | 9.88 | 350 | 368074 | 32689 | 46284949 |
Foetal death | 13.79 | 9.88 | 117 | 368307 | 8626 | 46309012 |
Post procedural infection | 13.74 | 9.88 | 104 | 368320 | 7409 | 46310229 |
Lymphadenectomy | 13.64 | 9.88 | 25 | 368399 | 871 | 46316767 |
Laryngospasm | 13.61 | 9.88 | 3 | 368421 | 2870 | 46314768 |
Gastrooesophageal reflux disease | 13.53 | 9.88 | 717 | 367707 | 73627 | 46244011 |
Spinal stenosis | 13.50 | 9.88 | 155 | 368269 | 12388 | 46305250 |
Back pain | 13.50 | 9.88 | 1873 | 366551 | 208166 | 46109472 |
Wound infection | 13.48 | 9.88 | 133 | 368291 | 10226 | 46307412 |
Chronic kidney disease | 13.46 | 9.88 | 234 | 368190 | 40637 | 46277001 |
Scleritis | 13.45 | 9.88 | 52 | 368372 | 2860 | 46314778 |
Pulmonary oedema | 13.39 | 9.88 | 304 | 368120 | 50801 | 46266837 |
Pharyngitis | 13.38 | 9.88 | 204 | 368220 | 17379 | 46300259 |
Osteopenia | 13.38 | 9.88 | 198 | 368226 | 16763 | 46300875 |
Mouth ulceration | 13.27 | 9.88 | 291 | 368133 | 26541 | 46291097 |
Inadequate analgesia | 13.27 | 9.88 | 3 | 368421 | 2821 | 46314817 |
Pain in jaw | 13.18 | 9.88 | 218 | 368206 | 38154 | 46279484 |
Cognitive disorder | 13.18 | 9.88 | 208 | 368216 | 36675 | 46280963 |
Lung neoplasm malignant | 13.09 | 9.88 | 183 | 368241 | 15306 | 46302332 |
Catheter management | 13.07 | 9.88 | 3 | 368421 | 2792 | 46314846 |
Cholestasis of pregnancy | 13.06 | 9.88 | 28 | 368396 | 1096 | 46316542 |
Maternal exposure during breast feeding | 13.04 | 9.88 | 50 | 368374 | 2739 | 46314899 |
Condition aggravated | 13.03 | 9.88 | 2162 | 366262 | 242890 | 46074748 |
Myopathy | 13 | 9.88 | 32 | 368392 | 8849 | 46308789 |
Incoherent | 12.91 | 9.88 | 10 | 368414 | 4502 | 46313136 |
Morning sickness | 12.88 | 9.88 | 21 | 368403 | 665 | 46316973 |
Haematocrit decreased | 12.82 | 9.88 | 365 | 368059 | 34692 | 46282946 |
Hyperuricaemia | 12.82 | 9.88 | 11 | 368413 | 4706 | 46312932 |
Product prescribing error | 12.80 | 9.88 | 99 | 368325 | 19948 | 46297690 |
Product substitution issue | 12.79 | 9.88 | 68 | 368356 | 14963 | 46302675 |
Cardiac failure acute | 12.71 | 9.88 | 28 | 368396 | 8050 | 46309588 |
Palpitations | 12.70 | 9.88 | 618 | 367806 | 94641 | 46222997 |
Vertigo | 12.69 | 9.88 | 313 | 368111 | 51735 | 46265903 |
Haematoma | 12.69 | 9.88 | 176 | 368248 | 31696 | 46285942 |
Dehydration | 12.66 | 9.88 | 1085 | 367339 | 158455 | 46159183 |
Bone density abnormal | 12.59 | 9.88 | 53 | 368371 | 3031 | 46314607 |
Orthostatic hypotension | 12.57 | 9.88 | 129 | 368295 | 24529 | 46293109 |
Mass | 12.54 | 9.88 | 144 | 368280 | 11509 | 46306129 |
Stillbirth | 12.52 | 9.88 | 91 | 368333 | 6400 | 46311238 |
Poor venous access | 12.49 | 9.88 | 110 | 368314 | 8198 | 46309440 |
Lip swelling | 12.48 | 9.88 | 134 | 368290 | 25261 | 46292377 |
Proteinuria | 12.41 | 9.88 | 78 | 368346 | 16475 | 46301163 |
Hypertransaminasaemia | 12.39 | 9.88 | 6 | 368418 | 3482 | 46314156 |
Hepatitis cholestatic | 12.37 | 9.88 | 21 | 368403 | 6656 | 46310982 |
Disease recurrence | 12.37 | 9.88 | 90 | 368334 | 18381 | 46299257 |
Cartilage injury | 12.35 | 9.88 | 34 | 368390 | 1563 | 46316075 |
Sickle cell anaemia | 12.33 | 9.88 | 19 | 368405 | 573 | 46317065 |
Paralysis | 12.32 | 9.88 | 32 | 368392 | 8689 | 46308949 |
Metabolic surgery | 12.24 | 9.88 | 25 | 368399 | 945 | 46316693 |
Labelled drug-drug interaction medication error | 12.23 | 9.88 | 34 | 368390 | 9027 | 46308611 |
Potentiating drug interaction | 12.13 | 9.88 | 8 | 368416 | 3915 | 46313723 |
Human antichimeric antibody positive | 12.09 | 9.88 | 31 | 368393 | 1365 | 46316273 |
Antinuclear antibody positive | 12.09 | 9.88 | 88 | 368336 | 6192 | 46311446 |
Dysphagia | 12.06 | 9.88 | 493 | 367931 | 76819 | 46240819 |
Cerebrovascular accident | 12.04 | 9.88 | 663 | 367761 | 100376 | 46217262 |
Tubulointerstitial nephritis | 11.98 | 9.88 | 68 | 368356 | 14720 | 46302918 |
Antibody test positive | 11.98 | 9.88 | 41 | 368383 | 2124 | 46315514 |
Congenital neuropathy | 11.98 | 9.88 | 5 | 368419 | 17 | 46317621 |
Interstitial lung disease | 11.95 | 9.88 | 329 | 368095 | 53620 | 46264018 |
Talipes | 11.93 | 9.88 | 31 | 368393 | 1376 | 46316262 |
Sinus bradycardia | 11.92 | 9.88 | 62 | 368362 | 13720 | 46303918 |
Cardiomyopathy | 11.92 | 9.88 | 76 | 368348 | 15997 | 46301641 |
Crying | 11.87 | 9.88 | 108 | 368316 | 21033 | 46296605 |
Ileus paralytic | 11.84 | 9.88 | 10 | 368414 | 4313 | 46313325 |
Irritability | 11.83 | 9.88 | 159 | 368265 | 28787 | 46288851 |
Septic shock | 11.82 | 9.88 | 357 | 368067 | 57536 | 46260102 |
Infection susceptibility increased | 11.82 | 9.88 | 41 | 368383 | 2138 | 46315500 |
Colitis microscopic | 11.80 | 9.88 | 21 | 368403 | 6535 | 46311103 |
Wrong technique in product usage process | 11.77 | 9.88 | 333 | 368091 | 54089 | 46263549 |
Renal mass | 11.71 | 9.88 | 36 | 368388 | 1762 | 46315876 |
Diabetes mellitus | 11.69 | 9.88 | 303 | 368121 | 49762 | 46267876 |
Cardiotoxicity | 11.69 | 9.88 | 22 | 368402 | 6700 | 46310938 |
Delusion | 11.66 | 9.88 | 47 | 368377 | 11141 | 46306497 |
Hyperthermia | 11.63 | 9.88 | 29 | 368395 | 7985 | 46309653 |
Tooth disorder | 11.61 | 9.88 | 253 | 368171 | 23050 | 46294588 |
Cushingoid | 11.60 | 9.88 | 87 | 368337 | 6179 | 46311459 |
Magnesium deficiency | 11.58 | 9.88 | 16 | 368408 | 436 | 46317202 |
Hysterectomy | 11.55 | 9.88 | 103 | 368321 | 7703 | 46309935 |
Infective thrombosis | 11.55 | 9.88 | 3 | 368421 | 0 | 46317638 |
Protein total | 11.55 | 9.88 | 3 | 368421 | 0 | 46317638 |
Dermatitis exfoliative | 11.52 | 9.88 | 17 | 368407 | 5699 | 46311939 |
Hepatotoxicity | 11.48 | 9.88 | 134 | 368290 | 24875 | 46292763 |
Catheter site pain | 11.45 | 9.88 | 8 | 368416 | 3798 | 46313840 |
Abdominal pain upper | 11.42 | 9.88 | 1312 | 367112 | 143993 | 46173645 |
Graft versus host disease in gastrointestinal tract | 11.41 | 9.88 | 3 | 368421 | 2547 | 46315091 |
Arthritis bacterial | 11.40 | 9.88 | 81 | 368343 | 5655 | 46311983 |
Emotional distress | 11.37 | 9.88 | 172 | 368252 | 30535 | 46287103 |
Lip pruritus | 11.37 | 9.88 | 17 | 368407 | 499 | 46317139 |
Drug ineffective | 11.30 | 9.88 | 5698 | 362726 | 672140 | 45645498 |
Dystonia | 11.29 | 9.88 | 48 | 368376 | 11209 | 46306429 |
Pancreatitis | 11.29 | 9.88 | 260 | 368164 | 43367 | 46274271 |
Joint lock | 11.26 | 9.88 | 39 | 368385 | 2032 | 46315606 |
Sepsis | 11.24 | 9.88 | 922 | 367502 | 135092 | 46182546 |
Atrioventricular block | 11.23 | 9.88 | 23 | 368401 | 6788 | 46310850 |
Ingrown hair | 11.15 | 9.88 | 16 | 368408 | 452 | 46317186 |
Epstein-Barr virus infection | 11.11 | 9.88 | 23 | 368401 | 6761 | 46310877 |
Bradykinesia | 11.08 | 9.88 | 9 | 368415 | 3957 | 46313681 |
Joint dislocation | 11.06 | 9.88 | 136 | 368288 | 11050 | 46306588 |
Foetal distress syndrome | 11.03 | 9.88 | 28 | 368396 | 1225 | 46316413 |
Hospitalisation | 11.02 | 9.88 | 399 | 368025 | 62986 | 46254652 |
Abortion incomplete | 11.02 | 9.88 | 6 | 368418 | 3258 | 46314380 |
Chest discomfort | 11 | 9.88 | 591 | 367833 | 89678 | 46227960 |
Skin laceration | 10.92 | 9.88 | 206 | 368218 | 18296 | 46299342 |
Platelet count decreased | 10.90 | 9.88 | 662 | 367762 | 99362 | 46218276 |
Dactylitis | 10.86 | 9.88 | 27 | 368397 | 1166 | 46316472 |
Joint warmth | 10.83 | 9.88 | 28 | 368396 | 1239 | 46316399 |
Drug abuser | 10.83 | 9.88 | 6 | 368418 | 3227 | 46314411 |
Gonorrhoea | 10.82 | 9.88 | 9 | 368415 | 134 | 46317504 |
Depression | 10.80 | 9.88 | 1176 | 367248 | 168928 | 46148710 |
Respiratory acidosis | 10.80 | 9.88 | 20 | 368404 | 6128 | 46311510 |
Chronic graft versus host disease | 10.78 | 9.88 | 4 | 368420 | 2721 | 46314917 |
Anterior chamber cleavage syndrome | 10.75 | 9.88 | 10 | 368414 | 174 | 46317464 |
Vascular rupture | 10.73 | 9.88 | 28 | 368396 | 1246 | 46316392 |
Upper limb fracture | 10.72 | 9.88 | 179 | 368245 | 15534 | 46302104 |
Product compounding quality issue | 10.71 | 9.88 | 9 | 368415 | 136 | 46317502 |
Urinary retention | 10.70 | 9.88 | 143 | 368281 | 25918 | 46291720 |
Chondropathy | 10.63 | 9.88 | 37 | 368387 | 1933 | 46315705 |
Stress | 10.58 | 9.88 | 503 | 367921 | 51048 | 46266590 |
Musculoskeletal disorder | 10.57 | 9.88 | 177 | 368247 | 15368 | 46302270 |
Device breakage | 10.56 | 9.88 | 40 | 368384 | 9652 | 46307986 |
Maternal exposure before pregnancy | 10.55 | 9.88 | 66 | 368358 | 4415 | 46313223 |
Hyperprolactinaemia | 10.48 | 9.88 | 5 | 368419 | 2927 | 46314711 |
Complication associated with device | 10.46 | 9.88 | 75 | 368349 | 15366 | 46302272 |
Hepatitis fulminant | 10.44 | 9.88 | 7 | 368417 | 3395 | 46314243 |
Incorrect route of product administration | 10.42 | 9.88 | 81 | 368343 | 16302 | 46301336 |
Forceps delivery | 10.34 | 9.88 | 10 | 368414 | 183 | 46317455 |
Sciatica | 10.29 | 9.88 | 209 | 368215 | 18811 | 46298827 |
Paradoxical drug reaction | 10.25 | 9.88 | 3 | 368421 | 2373 | 46315265 |
Spinal cord neoplasm | 10.25 | 9.88 | 11 | 368413 | 229 | 46317409 |
Tendon disorder | 10.20 | 9.88 | 71 | 368353 | 4924 | 46312714 |
Genital haemorrhage | 10.14 | 9.88 | 23 | 368401 | 6543 | 46311095 |
Acute myocardial infarction | 10.12 | 9.88 | 184 | 368240 | 31740 | 46285898 |
Intracranial pressure increased | 10.12 | 9.88 | 11 | 368413 | 4209 | 46313429 |
Vacuum extractor delivery | 10.09 | 9.88 | 9 | 368415 | 148 | 46317490 |
Dermatitis bullous | 10.08 | 9.88 | 29 | 368395 | 7614 | 46310024 |
Hernia | 10.08 | 9.88 | 119 | 368305 | 9576 | 46308062 |
Haemorrhage in pregnancy | 10.05 | 9.88 | 32 | 368392 | 1596 | 46316042 |
Hepatic necrosis | 10.03 | 9.88 | 18 | 368406 | 5583 | 46312055 |
Foetal anticonvulsant syndrome | 10.01 | 9.88 | 15 | 368409 | 441 | 46317197 |
Catheter site erythema | 9.98 | 9.88 | 10 | 368414 | 3973 | 46313665 |
Tooth fracture | 9.98 | 9.88 | 116 | 368308 | 9299 | 46308339 |
Spinal disorder | 9.95 | 9.88 | 102 | 368322 | 7922 | 46309716 |
Acute coronary syndrome | 9.93 | 9.88 | 44 | 368380 | 10160 | 46307478 |
Complication of pregnancy | 9.90 | 9.88 | 16 | 368408 | 503 | 46317135 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Rheumatoid arthritis | 349.20 | 9.99 | 723 | 162057 | 40474 | 29749224 |
Drug abuse | 310.08 | 9.99 | 40 | 162740 | 82032 | 29707666 |
Toxicity to various agents | 292.78 | 9.99 | 319 | 162461 | 176864 | 29612834 |
Completed suicide | 275.93 | 9.99 | 98 | 162682 | 99394 | 29690304 |
Arthralgia | 179.61 | 9.99 | 1308 | 161472 | 134483 | 29655215 |
Drug interaction | 161.99 | 9.99 | 550 | 162230 | 199018 | 29590680 |
Foetal exposure during pregnancy | 156.94 | 9.99 | 499 | 162281 | 36372 | 29753326 |
Intentional overdose | 118.12 | 9.99 | 39 | 162741 | 41442 | 29748256 |
Psoriatic arthropathy | 115.55 | 9.99 | 261 | 162519 | 15500 | 29774198 |
Joint swelling | 99.96 | 9.99 | 512 | 162268 | 46434 | 29743264 |
Nasopharyngitis | 89.50 | 9.99 | 587 | 162193 | 58262 | 29731436 |
Overdose | 85.41 | 9.99 | 209 | 162571 | 84128 | 29705570 |
Sickle cell anaemia with crisis | 83.60 | 9.99 | 83 | 162697 | 2319 | 29787379 |
Acute kidney injury | 77.60 | 9.99 | 1036 | 161744 | 272806 | 29516892 |
Premature baby | 72.91 | 9.99 | 228 | 162552 | 16463 | 29773235 |
Suicide attempt | 72.37 | 9.99 | 56 | 162724 | 36641 | 29753057 |
Exposure during pregnancy | 67.47 | 9.99 | 153 | 162627 | 9108 | 29780590 |
Drug reaction with eosinophilia and systemic symptoms | 62.09 | 9.99 | 39 | 162741 | 28449 | 29761249 |
Rhabdomyolysis | 59.42 | 9.99 | 164 | 162616 | 63416 | 29726282 |
Neonatal respiratory distress syndrome | 59.41 | 9.99 | 90 | 162690 | 3922 | 29785776 |
Haemoglobin decreased | 59.41 | 9.99 | 910 | 161870 | 113188 | 29676510 |
Blood pressure fluctuation | 57.96 | 9.99 | 218 | 162562 | 17285 | 29772413 |
Hepatic function abnormal | 57.21 | 9.99 | 87 | 162693 | 41858 | 29747840 |
Serotonin syndrome | 56.12 | 9.99 | 14 | 162766 | 17877 | 29771821 |
Tenosynovitis | 55.13 | 9.99 | 81 | 162699 | 3434 | 29786264 |
Musculoskeletal stiffness | 53.37 | 9.99 | 356 | 162424 | 35525 | 29754173 |
Enthesopathy | 53.03 | 9.99 | 72 | 162708 | 2834 | 29786864 |
Death | 51.82 | 9.99 | 1513 | 161267 | 355770 | 29433928 |
Atrial septal defect | 50.26 | 9.99 | 112 | 162668 | 6589 | 29783109 |
Infusion related reaction | 47.44 | 9.99 | 380 | 162400 | 40184 | 29749514 |
Pain | 46.87 | 9.99 | 1249 | 161531 | 171392 | 29618306 |
Maternal drugs affecting foetus | 45.95 | 9.99 | 83 | 162697 | 4190 | 29785508 |
Respiratory arrest | 45.65 | 9.99 | 55 | 162725 | 29203 | 29760495 |
Intentional product misuse | 45.29 | 9.99 | 74 | 162706 | 34593 | 29755105 |
Product use in unapproved indication | 44.71 | 9.99 | 227 | 162553 | 73466 | 29716232 |
Arthritis | 44.39 | 9.99 | 255 | 162525 | 24146 | 29765552 |
Coma | 44.34 | 9.99 | 96 | 162684 | 40353 | 29749345 |
Cytomegalovirus infection | 41.95 | 9.99 | 40 | 162740 | 23634 | 29766064 |
Psoriasis | 41.72 | 9.99 | 383 | 162397 | 42123 | 29747575 |
Coombs positive haemolytic anaemia | 41.61 | 9.99 | 34 | 162746 | 731 | 29788967 |
Febrile neutropenia | 41.10 | 9.99 | 376 | 162404 | 106317 | 29683381 |
Hypospadias | 40.96 | 9.99 | 61 | 162719 | 2618 | 29787080 |
Cardiac failure | 40.48 | 9.99 | 276 | 162504 | 83142 | 29706556 |
Maternal exposure during breast feeding | 38.59 | 9.99 | 46 | 162734 | 1586 | 29788112 |
Basal cell carcinoma | 38.28 | 9.99 | 181 | 162599 | 15887 | 29773811 |
Hypoglycaemia neonatal | 38.06 | 9.99 | 45 | 162735 | 1538 | 29788160 |
Intentional self-injury | 38.03 | 9.99 | 13 | 162767 | 13519 | 29776179 |
Maternal exposure during pregnancy | 37.63 | 9.99 | 72 | 162708 | 3799 | 29785899 |
Low birth weight baby | 37.37 | 9.99 | 94 | 162686 | 5982 | 29783716 |
Cardiac arrest | 36.72 | 9.99 | 325 | 162455 | 92525 | 29697173 |
Renal failure | 36.72 | 9.99 | 487 | 162293 | 128479 | 29661219 |
Small for dates baby | 36.67 | 9.99 | 64 | 162716 | 3144 | 29786554 |
Tongue disorder | 35.57 | 9.99 | 75 | 162705 | 4247 | 29785451 |
Haemolysis | 35.56 | 9.99 | 103 | 162677 | 7128 | 29782570 |
Immune reconstitution inflammatory syndrome | 35.41 | 9.99 | 4 | 162776 | 9097 | 29780601 |
Dysmorphism | 35.34 | 9.99 | 49 | 162731 | 1968 | 29787730 |
Ventricular septal defect | 34.75 | 9.99 | 66 | 162714 | 3463 | 29786235 |
Renal impairment | 34.47 | 9.99 | 292 | 162488 | 83892 | 29705806 |
Pain in extremity | 34.18 | 9.99 | 812 | 161968 | 109409 | 29680289 |
Poisoning | 33.64 | 9.99 | 10 | 162770 | 11372 | 29778326 |
Drug resistance | 33.41 | 9.99 | 36 | 162744 | 20097 | 29769601 |
Synovitis | 33.35 | 9.99 | 123 | 162657 | 9660 | 29780038 |
Grip strength decreased | 32.62 | 9.99 | 49 | 162731 | 2119 | 29787579 |
Syndactyly | 32.38 | 9.99 | 29 | 162751 | 709 | 29788989 |
Osteoarthritis | 32.23 | 9.99 | 190 | 162590 | 18159 | 29771539 |
Lactic acidosis | 31.84 | 9.99 | 77 | 162703 | 31136 | 29758562 |
Bradycardia | 31.19 | 9.99 | 218 | 162562 | 65308 | 29724390 |
Angioedema | 31.14 | 9.99 | 90 | 162690 | 34294 | 29755404 |
Arthropathy | 31.02 | 9.99 | 206 | 162574 | 20521 | 29769177 |
C-reactive protein abnormal | 29.78 | 9.99 | 82 | 162698 | 5511 | 29784187 |
Depressed level of consciousness | 29.77 | 9.99 | 107 | 162673 | 38115 | 29751583 |
Suicidal ideation | 29.54 | 9.99 | 99 | 162681 | 36015 | 29753683 |
Delirium | 29.54 | 9.99 | 117 | 162663 | 40514 | 29749184 |
Pulmonary fibrosis | 28.86 | 9.99 | 166 | 162614 | 15724 | 29773974 |
Cellulitis | 28.63 | 9.99 | 384 | 162396 | 46400 | 29743298 |
Cryptorchism | 28.28 | 9.99 | 40 | 162740 | 1637 | 29788061 |
Fatigue | 28.27 | 9.99 | 2064 | 160716 | 318609 | 29471089 |
Agitation | 28.20 | 9.99 | 175 | 162605 | 53898 | 29735800 |
Muscle swelling | 27.71 | 9.99 | 20 | 162760 | 355 | 29789343 |
Substance abuse | 27.63 | 9.99 | 3 | 162777 | 7037 | 29782661 |
Agranulocytosis | 27.58 | 9.99 | 48 | 162732 | 21894 | 29767804 |
Blood pressure systolic abnormal | 26.99 | 9.99 | 37 | 162743 | 1470 | 29788228 |
Peripheral swelling | 26.88 | 9.99 | 474 | 162306 | 60600 | 29729098 |
Electrocardiogram QT prolonged | 26.81 | 9.99 | 102 | 162678 | 35733 | 29753965 |
Large for dates baby | 26.53 | 9.99 | 28 | 162752 | 842 | 29788856 |
Blood pressure increased | 26.43 | 9.99 | 543 | 162237 | 71385 | 29718313 |
Drug dependence | 26.39 | 9.99 | 47 | 162733 | 21248 | 29768450 |
Sedation | 26.38 | 9.99 | 30 | 162750 | 16343 | 29773355 |
Exposure via breast milk | 25.78 | 9.99 | 37 | 162743 | 1535 | 29788163 |
Weight decreased | 25.63 | 9.99 | 1033 | 161747 | 149888 | 29639810 |
Foetal anticonvulsant syndrome | 25.57 | 9.99 | 26 | 162754 | 748 | 29788950 |
Skin cancer | 25.40 | 9.99 | 98 | 162682 | 7863 | 29781835 |
Lower respiratory tract infection | 25.35 | 9.99 | 239 | 162541 | 26475 | 29763223 |
Sinusitis | 25.30 | 9.99 | 285 | 162495 | 33060 | 29756638 |
Multiple organ dysfunction syndrome | 25.18 | 9.99 | 222 | 162558 | 63265 | 29726433 |
Hypoglycaemia | 25.05 | 9.99 | 168 | 162612 | 50813 | 29738885 |
Alanine aminotransferase abnormal | 24.59 | 9.99 | 48 | 162732 | 2571 | 29787127 |
Drug withdrawal syndrome | 24.30 | 9.99 | 44 | 162736 | 19765 | 29769933 |
Therapeutic product effect decreased | 24.13 | 9.99 | 253 | 162527 | 28823 | 29760875 |
Poor venous access | 23.95 | 9.99 | 46 | 162734 | 2434 | 29787264 |
Knee arthroplasty | 23.75 | 9.99 | 76 | 162704 | 5554 | 29784144 |
Skin lesion | 23.69 | 9.99 | 177 | 162603 | 18317 | 29771381 |
Cholestasis | 23.56 | 9.99 | 64 | 162716 | 24886 | 29764812 |
Hepatocellular injury | 23.56 | 9.99 | 66 | 162714 | 25405 | 29764293 |
Aggression | 23.34 | 9.99 | 112 | 162668 | 36795 | 29752903 |
Lymphadenitis | 23.26 | 9.99 | 37 | 162743 | 1683 | 29788015 |
Off label use | 23.17 | 9.99 | 1113 | 161667 | 248177 | 29541521 |
Palmar-plantar erythrodysaesthesia syndrome | 23.14 | 9.99 | 28 | 162752 | 14842 | 29774856 |
Vitamin D deficiency | 22.92 | 9.99 | 71 | 162709 | 5099 | 29784599 |
Blood creatine phosphokinase increased | 22.81 | 9.99 | 142 | 162638 | 43706 | 29745992 |
Pneumonia | 22.74 | 9.99 | 2110 | 160670 | 332196 | 29457502 |
Blood pressure systolic increased | 22.51 | 9.99 | 150 | 162630 | 14960 | 29774738 |
Rheumatoid nodule | 22.36 | 9.99 | 36 | 162744 | 1654 | 29788044 |
Drug intolerance | 21.92 | 9.99 | 357 | 162423 | 44934 | 29744764 |
Somnolence | 21.83 | 9.99 | 382 | 162398 | 96381 | 29693317 |
Red blood cell count decreased | 21.83 | 9.99 | 229 | 162551 | 26092 | 29763606 |
Congenital hand malformation | 21.82 | 9.99 | 19 | 162761 | 447 | 29789251 |
Post procedural infection | 21.41 | 9.99 | 64 | 162716 | 4508 | 29785190 |
Haematocrit decreased | 21.34 | 9.99 | 258 | 162522 | 30441 | 29759257 |
Mass | 21.25 | 9.99 | 86 | 162694 | 7054 | 29782644 |
Neuroleptic malignant syndrome | 21.08 | 9.99 | 35 | 162745 | 16260 | 29773438 |
Influenza | 20.98 | 9.99 | 342 | 162438 | 43056 | 29746642 |
Juvenile idiopathic arthritis | 20.82 | 9.99 | 27 | 162753 | 1016 | 29788682 |
Serum ferritin increased | 20.80 | 9.99 | 71 | 162709 | 5366 | 29784332 |
Cardio-respiratory arrest | 20.74 | 9.99 | 205 | 162575 | 57101 | 29732597 |
Musculoskeletal pain | 20.63 | 9.99 | 258 | 162522 | 30682 | 29759016 |
Shock | 20.58 | 9.99 | 60 | 162720 | 22799 | 29766899 |
Oropharyngeal pain | 20.47 | 9.99 | 241 | 162539 | 28255 | 29761443 |
Status epilepticus | 20.45 | 9.99 | 18 | 162762 | 11054 | 29778644 |
Arthritis bacterial | 20.44 | 9.99 | 62 | 162718 | 4402 | 29785296 |
Hyperglycaemia | 19.90 | 9.99 | 111 | 162669 | 35089 | 29754609 |
Pancytopenia | 19.87 | 9.99 | 604 | 162176 | 84448 | 29705250 |
Caesarean section | 19.86 | 9.99 | 39 | 162741 | 2098 | 29787600 |
Selective eating disorder | 19.78 | 9.99 | 34 | 162746 | 1650 | 29788048 |
Psychotic disorder | 19.71 | 9.99 | 56 | 162724 | 21459 | 29768239 |
Medical device implantation | 19.57 | 9.99 | 19 | 162761 | 516 | 29789182 |
Interstitial lung disease | 19.50 | 9.99 | 221 | 162559 | 59976 | 29729722 |
Tendonitis | 19.49 | 9.99 | 91 | 162689 | 7945 | 29781753 |
Immunodeficiency | 19.06 | 9.99 | 59 | 162721 | 4235 | 29785463 |
Injection site pain | 19.04 | 9.99 | 250 | 162530 | 30060 | 29759638 |
Incorrect route of product administration | 19.03 | 9.99 | 20 | 162760 | 11295 | 29778403 |
Back pain | 18.99 | 9.99 | 709 | 162071 | 101887 | 29687811 |
Tonsil cancer | 18.74 | 9.99 | 22 | 162758 | 746 | 29788952 |
Kidney infection | 18.59 | 9.99 | 61 | 162719 | 4517 | 29785181 |
Toxic epidermal necrolysis | 18.50 | 9.99 | 44 | 162736 | 17896 | 29771802 |
Localised infection | 18.47 | 9.99 | 133 | 162647 | 13604 | 29776094 |
Wound | 18.40 | 9.99 | 123 | 162657 | 12279 | 29777419 |
Body temperature decreased | 18.28 | 9.99 | 102 | 162678 | 9553 | 29780145 |
Agitation neonatal | 18.11 | 9.99 | 25 | 162755 | 1000 | 29788698 |
Pyrexia | 18.09 | 9.99 | 1367 | 161413 | 293122 | 29496576 |
Eosinophilia | 17.95 | 9.99 | 61 | 162719 | 22099 | 29767599 |
Neutrophil count decreased | 17.93 | 9.99 | 146 | 162634 | 42308 | 29747390 |
Mean cell volume increased | 17.81 | 9.99 | 37 | 162743 | 2073 | 29787625 |
Full blood count decreased | 17.69 | 9.99 | 146 | 162634 | 15571 | 29774127 |
Altered state of consciousness | 17.41 | 9.99 | 53 | 162727 | 19866 | 29769832 |
Prostate cancer | 17.38 | 9.99 | 203 | 162577 | 23754 | 29765944 |
Cytokine release syndrome | 17.34 | 9.99 | 17 | 162763 | 9916 | 29779782 |
Talipes | 17.33 | 9.99 | 32 | 162748 | 1643 | 29788055 |
Malignant melanoma | 17.30 | 9.99 | 83 | 162697 | 7328 | 29782370 |
Loss of personal independence in daily activities | 17.22 | 9.99 | 186 | 162594 | 21349 | 29768349 |
Hypocalcaemia | 17.21 | 9.99 | 59 | 162721 | 21317 | 29768381 |
Hand deformity | 17.19 | 9.99 | 34 | 162746 | 1839 | 29787859 |
Joint range of motion decreased | 17.08 | 9.99 | 70 | 162710 | 5775 | 29783923 |
Foot deformity | 16.94 | 9.99 | 49 | 162731 | 3388 | 29786310 |
Joint effusion | 16.89 | 9.99 | 51 | 162729 | 3612 | 29786086 |
Speech disorder developmental | 16.83 | 9.99 | 26 | 162754 | 1153 | 29788545 |
Drug level increased | 16.65 | 9.99 | 48 | 162732 | 18306 | 29771392 |
Lacrimal disorder | 16.49 | 9.99 | 14 | 162766 | 318 | 29789380 |
Urinary tract infection | 16.38 | 9.99 | 520 | 162260 | 73139 | 29716559 |
Haemangioma congenital | 16.17 | 9.99 | 17 | 162763 | 509 | 29789189 |
Akathisia | 16.03 | 9.99 | 6 | 162774 | 5898 | 29783800 |
Venoocclusive liver disease | 15.92 | 9.99 | 8 | 162772 | 6605 | 29783093 |
Diabetic ketoacidosis | 15.86 | 9.99 | 40 | 162740 | 15946 | 29773752 |
Hepatic enzyme increased | 15.83 | 9.99 | 263 | 162517 | 33231 | 29756467 |
Foetal growth restriction | 15.68 | 9.99 | 49 | 162731 | 3536 | 29786162 |
Product quality issue | 15.67 | 9.99 | 51 | 162729 | 18723 | 29770975 |
Acute hepatic failure | 15.67 | 9.99 | 25 | 162755 | 11802 | 29777896 |
Hyperbilirubinaemia neonatal | 15.58 | 9.99 | 19 | 162761 | 671 | 29789027 |
Injection site bruising | 15.58 | 9.99 | 80 | 162700 | 7258 | 29782440 |
Rash maculo-papular | 15.57 | 9.99 | 78 | 162702 | 25340 | 29764358 |
Neurotoxicity | 15.53 | 9.99 | 30 | 162750 | 13152 | 29776546 |
Arthrodesis | 15.43 | 9.99 | 15 | 162765 | 408 | 29789290 |
Congenital bladder anomaly | 15.40 | 9.99 | 13 | 162767 | 293 | 29789405 |
Blood pressure diastolic increased | 15.25 | 9.99 | 41 | 162739 | 2717 | 29786981 |
Anal fistula | 15.20 | 9.99 | 52 | 162728 | 3934 | 29785764 |
Progressive multifocal leukoencephalopathy | 15.08 | 9.99 | 16 | 162764 | 8997 | 29780701 |
Drug eruption | 15.06 | 9.99 | 47 | 162733 | 17479 | 29772219 |
Asthma | 15.01 | 9.99 | 125 | 162655 | 36049 | 29753649 |
Neck mass | 14.88 | 9.99 | 27 | 162753 | 1368 | 29788330 |
Tachycardia | 14.80 | 9.99 | 297 | 162483 | 73442 | 29716256 |
Multiple congenital abnormalities | 14.80 | 9.99 | 16 | 162764 | 495 | 29789203 |
Crystal nephropathy | 14.67 | 9.99 | 14 | 162766 | 372 | 29789326 |
Back disorder | 14.62 | 9.99 | 68 | 162712 | 5926 | 29783772 |
Septic arthritis staphylococcal | 14.46 | 9.99 | 15 | 162765 | 442 | 29789256 |
Cleft lip | 14.44 | 9.99 | 13 | 162767 | 320 | 29789378 |
Spinal stenosis | 14.40 | 9.99 | 54 | 162726 | 4275 | 29785423 |
Weight decrease neonatal | 14.31 | 9.99 | 13 | 162767 | 324 | 29789374 |
Gamma-glutamyltransferase increased | 14.27 | 9.99 | 97 | 162683 | 29253 | 29760445 |
Bradycardia neonatal | 14.21 | 9.99 | 21 | 162759 | 895 | 29788803 |
Hypokalaemia | 14.09 | 9.99 | 190 | 162590 | 50002 | 29739696 |
Jaundice neonatal | 14.02 | 9.99 | 23 | 162757 | 1074 | 29788624 |
Ankyloglossia congenital | 13.94 | 9.99 | 12 | 162768 | 278 | 29789420 |
Lipase increased | 13.86 | 9.99 | 16 | 162764 | 8660 | 29781038 |
Blood pressure diastolic abnormal | 13.84 | 9.99 | 25 | 162755 | 1262 | 29788436 |
Upper respiratory tract infection | 13.83 | 9.99 | 218 | 162562 | 27258 | 29762440 |
Hypermobility syndrome | 13.52 | 9.99 | 11 | 162769 | 235 | 29789463 |
Hepatic failure | 13.51 | 9.99 | 119 | 162661 | 33924 | 29755774 |
Osteonecrosis of jaw | 13.28 | 9.99 | 54 | 162726 | 18564 | 29771134 |
Cataract | 13.26 | 9.99 | 179 | 162601 | 21656 | 29768042 |
Transaminases increased | 13.24 | 9.99 | 74 | 162706 | 23383 | 29766315 |
Aspergillus infection | 13.15 | 9.99 | 22 | 162758 | 10192 | 29779506 |
Foetal disorder | 13.08 | 9.99 | 17 | 162763 | 641 | 29789057 |
Hepatocellular carcinoma | 13.03 | 9.99 | 20 | 162760 | 9590 | 29780108 |
Cerebral haemorrhage | 13.03 | 9.99 | 115 | 162665 | 32772 | 29756926 |
Pleural fibrosis | 12.99 | 9.99 | 26 | 162754 | 1418 | 29788280 |
Hepatic encephalopathy | 12.96 | 9.99 | 37 | 162743 | 14155 | 29775543 |
Hallucination | 12.95 | 9.99 | 188 | 162592 | 48871 | 29740827 |
Nephrolithiasis | 12.92 | 9.99 | 198 | 162582 | 24612 | 29765086 |
Frequent bowel movements | 12.86 | 9.99 | 84 | 162696 | 8321 | 29781377 |
Immunosuppression | 12.84 | 9.99 | 59 | 162721 | 5116 | 29784582 |
Acute graft versus host disease | 12.81 | 9.99 | 8 | 162772 | 5856 | 29783842 |
Renal injury | 12.71 | 9.99 | 28 | 162752 | 11701 | 29777997 |
Proteinuria | 12.70 | 9.99 | 45 | 162735 | 16100 | 29773598 |
Renal aplasia | 12.68 | 9.99 | 17 | 162763 | 661 | 29789037 |
Patent ductus arteriosus | 12.67 | 9.99 | 42 | 162738 | 3127 | 29786571 |
Cystatin C increased | 12.66 | 9.99 | 3 | 162777 | 0 | 29789698 |
Gastrointestinal tract mucosal discolouration | 12.66 | 9.99 | 3 | 162777 | 0 | 29789698 |
Stevens-Johnson syndrome | 12.47 | 9.99 | 51 | 162729 | 17505 | 29772193 |
Haemorrhage intracranial | 12.43 | 9.99 | 41 | 162739 | 14991 | 29774707 |
Accidental overdose | 12.42 | 9.99 | 54 | 162726 | 18221 | 29771477 |
Hepatitis | 12.36 | 9.99 | 71 | 162709 | 22285 | 29767413 |
Heart rate decreased | 12.30 | 9.99 | 171 | 162609 | 20823 | 29768875 |
Thrombocytopenia | 12.27 | 9.99 | 614 | 162166 | 136430 | 29653268 |
Alcohol abuse | 12.12 | 9.99 | 7 | 162773 | 5346 | 29784352 |
Drug-induced liver injury | 12.07 | 9.99 | 67 | 162713 | 21207 | 29768491 |
Victim of child abuse | 11.95 | 9.99 | 11 | 162769 | 279 | 29789419 |
Disseminated intravascular coagulation | 11.95 | 9.99 | 71 | 162709 | 22100 | 29767598 |
Myoclonus | 11.94 | 9.99 | 35 | 162745 | 13277 | 29776421 |
Posterior reversible encephalopathy syndrome | 11.92 | 9.99 | 18 | 162762 | 8689 | 29781009 |
Pathogen resistance | 11.90 | 9.99 | 17 | 162763 | 8393 | 29781305 |
Arthritis infective | 11.88 | 9.99 | 37 | 162743 | 2665 | 29787033 |
Crohn's disease | 11.84 | 9.99 | 51 | 162729 | 4301 | 29785397 |
Hyperkalaemia | 11.75 | 9.99 | 271 | 162509 | 65739 | 29723959 |
Hernia pain | 11.75 | 9.99 | 10 | 162770 | 228 | 29789470 |
Vascular insufficiency | 11.69 | 9.99 | 12 | 162768 | 349 | 29789349 |
Dermatitis psoriasiform | 11.65 | 9.99 | 22 | 162758 | 1149 | 29788549 |
Maternal exposure timing unspecified | 11.61 | 9.99 | 12 | 162768 | 352 | 29789346 |
Chronic graft versus host disease | 11.50 | 9.99 | 4 | 162776 | 4115 | 29785583 |
Hyperammonaemia | 11.43 | 9.99 | 8 | 162772 | 5512 | 29784186 |
Nightmare | 11.38 | 9.99 | 31 | 162749 | 12045 | 29777653 |
Asthenia | 11.36 | 9.99 | 1371 | 161409 | 219919 | 29569779 |
Abnormal behaviour | 11.34 | 9.99 | 87 | 162693 | 25536 | 29764162 |
Hallucination, visual | 11.33 | 9.99 | 47 | 162733 | 16066 | 29773632 |
Intellectual disability | 11.29 | 9.99 | 18 | 162762 | 820 | 29788878 |
Pyelocaliectasis | 11.25 | 9.99 | 20 | 162760 | 997 | 29788701 |
Bronchopulmonary aspergillosis | 11.23 | 9.99 | 32 | 162748 | 12252 | 29777446 |
Cystitis haemorrhagic | 11.22 | 9.99 | 6 | 162774 | 4781 | 29784917 |
Coccydynia | 11.21 | 9.99 | 12 | 162768 | 367 | 29789331 |
Blood insulin increased | 11.18 | 9.99 | 12 | 162768 | 368 | 29789330 |
Subdural haematoma | 11.18 | 9.99 | 59 | 162721 | 18913 | 29770785 |
Peripheral artery thrombosis | 11.17 | 9.99 | 32 | 162748 | 2200 | 29787498 |
Anal atresia | 11.15 | 9.99 | 11 | 162769 | 305 | 29789393 |
Delusion | 11.13 | 9.99 | 31 | 162749 | 11958 | 29777740 |
Mouth ulceration | 11.12 | 9.99 | 97 | 162683 | 10512 | 29779186 |
Otitis media | 11.11 | 9.99 | 35 | 162745 | 2536 | 29787162 |
Contusion | 11.11 | 9.99 | 235 | 162545 | 31045 | 29758653 |
Joint stiffness | 11.10 | 9.99 | 88 | 162692 | 9273 | 29780425 |
Blood iron increased | 11.04 | 9.99 | 18 | 162762 | 836 | 29788862 |
Arthropod bite | 11.03 | 9.99 | 33 | 162747 | 2325 | 29787373 |
Myocardial infarction | 11.02 | 9.99 | 564 | 162216 | 125061 | 29664637 |
Anaphylactic shock | 11.01 | 9.99 | 39 | 162741 | 13954 | 29775744 |
Cerebral infarction | 11.00 | 9.99 | 91 | 162689 | 26282 | 29763416 |
Fistula | 10.98 | 9.99 | 56 | 162724 | 5066 | 29784632 |
Intervertebral disc degeneration | 10.98 | 9.99 | 57 | 162723 | 5194 | 29784504 |
Cytomegalovirus viraemia | 10.97 | 9.99 | 9 | 162771 | 5720 | 29783978 |
Rhinorrhoea | 10.95 | 9.99 | 166 | 162614 | 20588 | 29769110 |
Congenital anomaly | 10.95 | 9.99 | 23 | 162757 | 1299 | 29788399 |
Infected bite | 10.94 | 9.99 | 11 | 162769 | 312 | 29789386 |
Hepatitis C | 10.93 | 9.99 | 36 | 162744 | 13169 | 29776529 |
Infection | 10.92 | 9.99 | 524 | 162256 | 77550 | 29712148 |
Palindromic rheumatism | 10.92 | 9.99 | 9 | 162771 | 196 | 29789502 |
Microphthalmos | 10.92 | 9.99 | 9 | 162771 | 196 | 29789502 |
Hydrocele | 10.91 | 9.99 | 30 | 162750 | 2014 | 29787684 |
Lung hernia | 10.90 | 9.99 | 5 | 162775 | 35 | 29789663 |
Lung neoplasm malignant | 10.87 | 9.99 | 128 | 162652 | 15004 | 29774694 |
Injection site erythema | 10.83 | 9.99 | 119 | 162661 | 13715 | 29775983 |
Metabolic acidosis | 10.81 | 9.99 | 141 | 162639 | 37320 | 29752378 |
Joint instability | 10.80 | 9.99 | 12 | 162768 | 383 | 29789315 |
Diverticulum | 10.73 | 9.99 | 68 | 162712 | 6665 | 29783033 |
Blood iron decreased | 10.73 | 9.99 | 47 | 162733 | 3993 | 29785705 |
Hepatitis fulminant | 10.71 | 9.99 | 4 | 162776 | 3937 | 29785761 |
Steatorrhoea | 10.68 | 9.99 | 16 | 162764 | 690 | 29789008 |
Migraine | 10.67 | 9.99 | 112 | 162668 | 12762 | 29776936 |
Injection site swelling | 10.67 | 9.99 | 83 | 162697 | 8697 | 29781001 |
Pulmonary alveolar haemorrhage | 10.66 | 9.99 | 12 | 162768 | 6569 | 29783129 |
Plagiocephaly | 10.63 | 9.99 | 11 | 162769 | 323 | 29789375 |
Spinal operation | 10.62 | 9.99 | 32 | 162748 | 2264 | 29787434 |
Blood pressure diastolic decreased | 10.61 | 9.99 | 64 | 162716 | 6167 | 29783531 |
Excessive cerumen production | 10.60 | 9.99 | 10 | 162770 | 262 | 29789436 |
Exostosis | 10.59 | 9.99 | 42 | 162738 | 3413 | 29786285 |
Gangrene neonatal | 10.58 | 9.99 | 9 | 162771 | 205 | 29789493 |
Electrocardiogram QRS complex prolonged | 10.56 | 9.99 | 5 | 162775 | 4272 | 29785426 |
Neonatal seizure | 10.49 | 9.99 | 13 | 162767 | 467 | 29789231 |
Erythema multiforme | 10.47 | 9.99 | 17 | 162763 | 7968 | 29781730 |
Hypertransaminasaemia | 10.46 | 9.99 | 4 | 162776 | 3881 | 29785817 |
Graft versus host disease | 10.38 | 9.99 | 25 | 162755 | 10125 | 29779573 |
Tubulointerstitial nephritis | 10.34 | 9.99 | 56 | 162724 | 17835 | 29771863 |
Blister infected | 10.34 | 9.99 | 11 | 162769 | 334 | 29789364 |
Energy increased | 10.34 | 9.99 | 22 | 162758 | 1254 | 29788444 |
Nocardiosis | 10.28 | 9.99 | 3 | 162777 | 3452 | 29786246 |
Microcephaly | 10.19 | 9.99 | 15 | 162765 | 637 | 29789061 |
Malignant neoplasm progression | 10.17 | 9.99 | 307 | 162473 | 71980 | 29717718 |
Congenital diaphragmatic hernia | 10.15 | 9.99 | 9 | 162771 | 217 | 29789481 |
Folate deficiency | 10.10 | 9.99 | 19 | 162761 | 990 | 29788708 |
Drug withdrawal syndrome neonatal | 10.06 | 9.99 | 39 | 162741 | 3136 | 29786562 |
Umbilical hernia | 10.04 | 9.99 | 43 | 162737 | 3618 | 29786080 |
Foetal heart rate deceleration abnormality | 10.02 | 9.99 | 12 | 162768 | 416 | 29789282 |
Source | Code | Description |
---|---|---|
ATC | A11GA01 | ALIMENTARY TRACT AND METABOLISM VITAMINS ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS Ascorbic acid (vitamin C), plain |
ATC | A11GB01 | ALIMENTARY TRACT AND METABOLISM VITAMINS ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS Ascorbic acid (vitamin C), combinations |
ATC | G01AD03 | GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Organic acids |
ATC | S01XA15 | SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals |
FDA CS | M0001797 | Ascorbic Acid |
MeSH PA | D000975 | Antioxidants |
MeSH PA | D018977 | Micronutrients |
MeSH PA | D020011 | Protective Agents |
MeSH PA | D014815 | Vitamins |
FDA EPC | N0000193618 | Vitamin C |
CHEBI has role | CHEBI:21241 | vitaminum c |
CHEBI has role | CHEBI:23354 | coenzymes |
CHEBI has role | CHEBI:23357 | cofactor |
CHEBI has role | CHEBI:27314 | water-soluble vitamins |
CHEBI has role | CHEBI:64577 | improving agents |
CHEBI has role | CHEBI:76924 | plant metabolites |
CHEBI has role | CHEBI:77962 | food antioxidants |
CHEBI has role | CHEBI:77746 | h. sapiens metabolites |
CHEBI has role | CHEBI:83056 | daphnia magna metabolites |
CHEBI has role | CHEBI:63247 | reductants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Ascorbic acid deficiency | indication | 76169001 | |
Breastfeeding (mother) | indication | 413712001 | |
Coronavirus infection | off-label use | 186747009 | |
Anuria | contraindication | 2472002 | DOID:2983 |
Hypocalcemia | contraindication | 5291005 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Hyperkalemia | contraindication | 14140009 | |
Severe chronic ulcerative colitis | contraindication | 14311001 | |
Constipation | contraindication | 14760008 | DOID:2089 |
Operation on stomach | contraindication | 16453004 | |
Primary hyperoxaluria | contraindication | 17901006 | DOID:2977 |
Hypocupremia | contraindication | 19577007 | |
Hyperphosphatemia | contraindication | 20165001 | DOID:0050459 |
Sunburn | contraindication | 23346002 | |
Acute vomiting | contraindication | 23971007 | |
Multiple sclerosis | contraindication | 24700007 | DOID:2377 |
Gastroenteritis | contraindication | 25374005 | DOID:2326 |
Acute tuberculosis | contraindication | 25629007 | |
Hypervitaminosis D | contraindication | 27712000 | DOID:9971 |
Complete atrioventricular block | contraindication | 27885002 | |
Toxic megacolon | contraindication | 28536002 | DOID:1770 |
Dental fluorosis | contraindication | 30265004 | |
Sarcoidosis | contraindication | 31541009 | DOID:11335 |
Dehydration | contraindication | 34095006 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Hemosiderosis | contraindication | 39011001 | DOID:12119 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Toxic colitis | contraindication | 42359007 | |
Hypokalemia | contraindication | 43339004 | |
Gastrointestinal perforation | contraindication | 51875005 | |
Gastrectomy | contraindication | 53442002 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Hyperlipidemia | contraindication | 55822004 | DOID:1168 |
Congenital myotonia, autosomal dominant form | contraindication | 57938005 | |
Acute nephropathy | contraindication | 58574008 | |
Leber's optic atrophy | contraindication | 58610003 | DOID:705 |
Hemolytic anemia | contraindication | 61261009 | DOID:583 |
Allergic rhinitis | contraindication | 61582004 | |
Hypervitaminosis A | contraindication | 64559002 | DOID:9972 |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Rheumatoid arthritis | contraindication | 69896004 | DOID:7148 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hyperchloremia | contraindication | 74450001 | |
Third degree burn injury | contraindication | 80247002 | |
Intestinal obstruction | contraindication | 81060008 | DOID:8437 |
Atrophic gastritis | contraindication | 84568007 | DOID:8929 |
Human immunodeficiency virus infection | contraindication | 86406008 | DOID:526 |
Wilson's disease | contraindication | 88518009 | |
Hyponatremia | contraindication | 89627008 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Leukemia, disease | contraindication | 93143009 | DOID:1240 |
Kidney stone | contraindication | 95570007 | |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Gastrointestinal obstruction | contraindication | 126765001 | |
Hb SS disease | contraindication | 127040003 | DOID:10923 |
Seizure disorder | contraindication | 128613002 | |
Osteolysis | contraindication | 203522001 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Hyporeninemic hypoaldosteronism | contraindication | 236464008 | |
Esophageal dysmotility | contraindication | 266434009 | DOID:9192 |
Familial hyperkalemic periodic paralysis | contraindication | 304737009 | DOID:14451 |
Gastric retention | contraindication | 307227006 | |
Arteriosclerosis obliterans | contraindication | 361133006 | DOID:5160 |
At risk for aspiration | contraindication | 371736008 | |
Diverticular disease | contraindication | 397881000 | |
Hemochromatosis | contraindication | 399187006 | DOID:2352 |
Denuded skin | contraindication | 418242004 | |
Severe dehydration | contraindication | 450316000 | |
Acute exacerbation of asthma | contraindication | 708038006 | |
Vitamin K Deficiency Induced Hypoprothrombinemia | contraindication | ||
Malabsorption States | contraindication | ||
Repeated Blood Transfusions | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.02 | acidic |
pKa2 | 9.62 | acidic |
pKa3 | 11.85 | acidic |
pKa4 | 12.53 | acidic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
4.7GM;100GM;1.015GM;5.9GM;2.691GM;7.5GM | PEG-3350, SODIUM SULFATE, SODIUM CHLORIDE, POTASSIUM CHLORIDE, SODIUM ASCORBATE AND ASCORBIC ACID | NOVEL LABS INC | A090145 | Jan. 25, 2012 | RX | FOR SOLUTION | ORAL | Feb. 27, 2021 | PATENT CHALLENGE |
7.54GM;140GM;2.2GM;48.11GM;5.2GM;9GM | PLENVU | SALIX | N209381 | May 4, 2018 | RX | FOR SOLUTION | ORAL | May 4, 2021 | NEW PRODUCT |
25,000MG/50ML (500MG/ML) | ASCOR | MCGUFF | N209112 | Oct. 2, 2017 | RX | SOLUTION | INTRAVENOUS | Oct. 2, 2024 | FOR TREATMENT OF SCURVY IN ADULT AND PEDIATRIC PATIENTS AGE 5 MONTHS AND OLDER FOR WHOM ORAL ADMINISTRATION IS NOT POSSIBLE, INSUFFICIENT OR CONTRAINDICATED |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Solute carrier family 23 member 1 | Unclassified | WOMBAT-PK | |||||||
Solute carrier family 23 member 2 | Transporter | WOMBAT-PK | |||||||
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Enzyme | WOMBAT-PK | |||||||
Prolyl 4-hydroxylase subunit alpha-1 | Enzyme | WOMBAT-PK | |||||||
Tyrosinase | Enzyme | IC50 | 4.49 | CHEMBL | |||||
Pancreatic alpha-amylase | Unclassified | IC50 | 4.58 | CHEMBL |
ID | Source |
---|---|
PQ6CK8PD0R | UNII |
4017646 | VUID |
N0000146025 | NUI |
D00018 | KEGG_DRUG |
5743-28-2 | SECONDARY_CAS_RN |
4017471 | VANDF |
4017472 | VANDF |
4017646 | VANDF |
4021716 | VANDF |
4026966 | VANDF |
C0003968 | UMLSCUI |
CHEBI:29073 | CHEBI |
ASC | PDB_CHEM_ID |
CHEMBL196 | ChEMBL_ID |
CHEMBL2146095 | ChEMBL_ID |
DB00126 | DRUGBANK_ID |
DB14483 | DRUGBANK_ID |
CHEMBL591665 | ChEMBL_ID |
D001205 | MESH_DESCRIPTOR_UI |
54670067 | PUBCHEM_CID |
372 | INN_ID |
C069207 | MESH_SUPPLEMENTAL_RECORD_UI |
4781 | IUPHAR_LIGAND_ID |
174 | INN_ID |
DB14482 | DRUGBANK_ID |
1151 | RXNORM |
1132 | MMSL |
32646 | MMSL |
4221 | MMSL |
5471 | MMSL |
5687 | MMSL |
6032 | MMSL |
72299 | MMSL |
NOCODE | MMSL |
d00426 | MMSL |
001010 | NDDF |
001011 | NDDF |
001012 | NDDF |
126230002 | SNOMEDCT_US |
126231003 | SNOMEDCT_US |
43706004 | SNOMEDCT_US |
46123006 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Ferralet 90 | HUMAN PRESCRIPTION DRUG LABEL | 5 | 0178-0089 | TABLET, FILM COATED | 120 mg | ORAL | unapproved drug other | 17 sections |
NataFort | HUMAN PRESCRIPTION DRUG LABEL | 10 | 0178-0716 | TABLET | 120 mg | ORAL | Unapproved drug other | 12 sections |
CitraNatal Bloom | HUMAN PRESCRIPTION DRUG LABEL | 6 | 0178-0813 | TABLET, FILM COATED | 138 mg | ORAL | unapproved drug other | 15 sections |
CitraNatal 90 DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0178-0821 | TABLET | 120 mg | ORAL | unapproved drug other | 11 sections |
CitraNatal 90 DHA | HUMAN OTC DRUG LABEL | 14 | 0178-0829 | TABLET | 120 mg | ORAL | Unapproved drug other | 11 sections |
CitraNatal Rx | HUMAN PRESCRIPTION DRUG LABEL | 13 | 0178-0858 | TABLET | 120 mg | ORAL | Unapproved drug other | 12 sections |
CitraNatal Rx | HUMAN PRESCRIPTION DRUG LABEL | 14 | 0178-0859 | TABLET | 120 mg | ORAL | Unapproved drug other | 9 sections |
CitraNatal DHA | HUMAN OTC DRUG LABEL | 14 | 0178-0898 | TABLET | 120 mg | ORAL | Unapproved drug other | 11 sections |
Antiflu Kids | HUMAN OTC DRUG LABEL | 3 | 0280-0046 | POWDER, FOR SOLUTION | 50 mg | ORAL | Export only | 2 sections |
VitafolOne | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0642-0070 | CAPSULE, GELATIN COATED | 30 mg | ORAL | unapproved drug other | 7 sections |
Vitafol Caplet | HUMAN PRESCRIPTION DRUG LABEL | 12 | 0642-0072 | CAPSULE | 60 mg | ORAL | UNULLPPROVED DRUG OTHER | 13 sections |
Select OB | HUMAN PRESCRIPTION DRUG LABEL | 15 | 0642-0077 | TABLET, CHEWABLE | 60 mg | ORAL | UNULLPPROVED DRUG OTHER | 14 sections |
Vitafol OB Caplet | HUMAN PRESCRIPTION DRUG LABEL | 15 | 0642-0079 | TABLET | 70 mg | ORAL | Unapproved drug other | 14 sections |
Vitafol Plus | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-0092 | CAPSULE, LIQUID FILLED | 12 mg | ORAL | UNULLPPROVED DRUG OTHER | 13 sections |
Vitafol Ultra | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-0093 | CAPSULE, LIQUID FILLED | 30 mg | ORAL | UNULLPPROVED DRUG OTHER | 13 sections |
Select OB | HUMAN PRESCRIPTION DRUG LABEL | 15 | 0642-0120 | TABLET, CHEWABLE | 60 mg | ORAL | UNULLPPROVED DRUG OTHER | 13 sections |
Strovite Forte Caplet | HUMAN PRESCRIPTION DRUG LABEL | 19 | 0642-0204 | TABLET, COATED | 500 mg | ORAL | UNULLPPROVED DRUG OTHER | 15 sections |
Strovite One Caplets | HUMAN PRESCRIPTION DRUG LABEL | 20 | 0642-0207 | TABLET | 300 mg | ORAL | UNULLPPROVED DRUG OTHER | 14 sections |
Reaphirm Plant Source DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0642-3010 | CAPSULE, GELATIN COATED | 30 mg | ORAL | unapproved drug other | 7 sections |
Vitafol Fe Plus | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-7473 | CAPSULE, LIQUID FILLED | 60 mg | ORAL | UNULLPPROVED DRUG OTHER | 14 sections |
Marnatal F | HUMAN PRESCRIPTION DRUG LABEL | 13 | 0682-1570 | CAPSULE | 100 mg | ORAL | UNULLPPROVED DRUG OTHER | 4 sections |
BACMIN | HUMAN PRESCRIPTION DRUG LABEL | 19 | 0682-3001 | TABLET, COATED | 500 mg | ORAL | UNULLPPROVED DRUG OTHER | 10 sections |
O-Cal Prenatal Vitamin | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0813-0202 | TABLET | 70 mg | ORAL | UNULLPPROVED DRUG OTHER | 6 sections |
Acetaminophen, Ascorbic acid, Chlorpheniramine Maleate | HUMAN OTC DRUG LABEL | 3 | 10267-2949 | POWDER, FOR SOLUTION | 50 mg | ORAL | Export only | 1 sections |
Dialyvite Supreme D | HUMAN PRESCRIPTION DRUG LABEL | 13 | 10542-009 | TABLET, COATED | 100 mg | ORAL | Unapproved drug other | 7 sections |
Dialyvite | HUMAN PRESCRIPTION DRUG LABEL | 9 | 10542-010 | TABLET, COATED | 100 mg | ORAL | Unapproved drug other | 7 sections |
Dialyvite 5000 | HUMAN PRESCRIPTION DRUG LABEL | 12 | 10542-011 | TABLET, COATED | 100 mg | ORAL | Unapproved drug other | 7 sections |
Dialyvite with Zinc | HUMAN PRESCRIPTION DRUG LABEL | 10 | 10542-012 | TABLET, COATED | 100 mg | ORAL | Unapproved drug other | 7 sections |
Dialyvite 3000 | HUMAN PRESCRIPTION DRUG LABEL | 12 | 10542-014 | TABLET, COATED | 100 mg | ORAL | Unapproved drug other | 7 sections |
PRENULLTAL PLUS | HUMAN PRESCRIPTION DRUG LABEL | 15 | 10544-549 | TABLET, FILM COATED | 120 mg | ORAL | unapproved drug other | 8 sections |