lactic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1533 50-21-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • DL-LACTIC ACID
  • lactic acid
  • lactate
  • (2RS)-2-Hydroxypropanoic acid
  • LACTIC ACID, DL-
A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
  • Molecular weight: 90.08
  • Formula: C3H6O3
  • CLOGP: -0.73
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 57.53
  • ALOGS: 0.79
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiovascular insufficiency 32.92 20.86 8 1679 1333 46683042
Haemorrhage 28.31 20.86 20 1667 54849 46629526
Blood phosphorus increased 27.03 20.86 8 1679 2811 46681564
Cerebral haematoma 25.69 20.86 8 1679 3331 46681044

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Haemorrhage 33.24 23.67 19 836 46060 29905563

Pharmacologic Action:

SourceCodeDescription
ATC G01AD01 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Organic acids
CHEBI has role CHEBI:76971 e.coli metabolites
CHEBI has role CHEBI:77746 h. sapiens metabolites
CHEBI has role CHEBI:64049 acidity regulators
CHEBI has role CHEBI:83056 daphnia magna metabolites
CHEBI has role CHEBI:84735 algal metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Itching of skin indication 418363000

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.95 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
1%;1.8%;0.4% PHEXXI EVOFEM INC N208352 May 22, 2020 RX GEL VAGINULLL May 22, 2023 NEW PRODUCT

Bioactivity Summary:

None

External reference:

IDSource
4018704 VUID
N0000147012 NUI
D00111 KEGG_DRUG
4018704 VANDF
4020226 VANDF
C2608095 UMLSCUI
CHEBI:24996 CHEBI
LAC PDB_CHEM_ID
CHEMBL1200559 ChEMBL_ID
CHEMBL358850 ChEMBL_ID
DB04398 DRUGBANK_ID
D019344 MESH_DESCRIPTOR_UI
612 PUBCHEM_CID
3B8D35Y7S4 UNII
114202 RXNORM
10698 MMSL
4952 MMSL
4953 MMSL
001956 NDDF
008589 NDDF
398659005 SNOMEDCT_US
77370004 SNOMEDCT_US

Pharmaceutical products:

None