lactic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1533 | 50-21-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Product dose omission issue | 22.13 | 19.96 | 31 | 1878 | 234282 | 63252831 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Product dose omission issue | 21.99 | 19.32 | 31 | 2249 | 247506 | 79494602 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G01AD01 | GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Organic acids |
| CHEBI has role | CHEBI:76971 | Escherichia coli metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
| CHEBI has role | CHEBI:64049 | pH control agents |
| CHEBI has role | CHEBI:83056 | Daphnia magna metabolites |
| CHEBI has role | CHEBI:84735 | algal metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Itching of skin | indication | 418363000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.95 | acidic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 1%;1.8%;0.4% | PHEXXI | EVOFEM INC | N208352 | May 22, 2020 | RX | GEL | VAGINAL | 10568855 | March 15, 2033 | PREVENTION OF PREGNANCY |
| 1%;1.8%;0.4% | PHEXXI | EVOFEM INC | N208352 | May 22, 2020 | RX | GEL | VAGINAL | 11337989 | March 15, 2033 | PREVENTION OF PREGNANCY |
Orange Book exclusivity data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
|---|---|---|---|---|---|---|---|---|---|
| 1%;1.8%;0.4% | PHEXXI | EVOFEM INC | N208352 | May 22, 2020 | RX | GEL | VAGINAL | May 22, 2023 | NEW PRODUCT |
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4018704 | VUID |
| N0000147012 | NUI |
| D00111 | KEGG_DRUG |
| 4018704 | VANDF |
| 4020226 | VANDF |
| C0064582 | UMLSCUI |
| CHEBI:28358 | CHEBI |
| LAC | PDB_CHEM_ID |
| CHEMBL1200559 | ChEMBL_ID |
| 612 | PUBCHEM_CID |
| DB04398 | DRUGBANK_ID |
| CHEMBL358850 | ChEMBL_ID |
| D019344 | MESH_DESCRIPTOR_UI |
| 114202 | RXNORM |
| 10698 | MMSL |
| 4952 | MMSL |
| 4953 | MMSL |
| 001956 | NDDF |
| 008589 | NDDF |
| 398659005 | SNOMEDCT_US |
| 77370004 | SNOMEDCT_US |
| 3B8D35Y7S4 | UNII |
Pharmaceutical products:
None