diiodohydroxyquinoline Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quinoline derivatives 1457 83-73-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • iodoquinol
  • diiodohydroxyquinoline
  • diiodohydroxyquin
  • diiodoquin
  • diiodoquinol
One of the halogenated 8-quinolinols widely used as an intestinal antiseptic, especially as an antiamebic agent. It is also used topically in other infections and may cause CNS and eye damage. It is known by very many similar trade names world-wide.
  • Molecular weight: 396.95
  • Formula: C9H5I2NO
  • CLOGP: 4.14
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 33.12
  • ALOGS: -3.69
  • ROTB: 0

Drug dosage:

DoseUnitRoute
0.20 g V

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC G01AC01 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Quinoline derivatives
CHEBI has role CHEBI:33282 antibacterials
CHEBI has role CHEBI:35820 antiprotozoal agent
CHEBI has role CHEBI:48218 antiseptics
CHEBI has role CHEBI:171664 antiamoebic drugs
MeSH PA D000563 Amebicides
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Amebic infection indication 111910009 DOID:9181
Atopic dermatitis off-label use 24079001 DOID:3310
Contact dermatitis off-label use 40275004 DOID:2773
Lichen simplex chronicus off-label use 53891004
Pruritus ani off-label use 90446007
Pruritus of genital organs off-label use 267802000
Eruption of skin off-label use 271807003 DOID:0050486
Optic neuritis contraindication 66760008 DOID:1210
Disease of liver contraindication 235856003 DOID:409
Telangiectasia disorder contraindication 247479008
Peripheral nerve disease contraindication 302226006
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.61 acidic
pKa2 2.03 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adenosine receptor A3 GPCR Ki 6.28 DRUG MATRIX
Epidermal growth factor receptor Kinase IC50 5.72 DRUG MATRIX
Tyrosine-protein kinase Lck Kinase IC50 5.61 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.80 DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2 Kinase IC50 5.07 DRUG MATRIX
Mitogen-activated protein kinase 3 Kinase IC50 5.28 DRUG MATRIX
Mitogen-activated protein kinase 14 Kinase IC50 6.44 DRUG MATRIX
Mitogen-activated protein kinase 1 Kinase IC50 6.53 DRUG MATRIX
Angiotensin-converting enzyme Enzyme IC50 6.04 DRUG MATRIX
Catechol O-methyltransferase Enzyme IC50 5.25 CHEMBL

External reference:

IDSource
4018600 VUID
N0000146916 NUI
D00581 KEGG_DRUG
4018600 VANDF
C0012341 UMLSCUI
CHEBI:5950 CHEBI
CHEMBL86754 ChEMBL_ID
DB09115 DRUGBANK_ID
D004103 MESH_DESCRIPTOR_UI
3728 PUBCHEM_CID
1613 INN_ID
63W7IE88K8 UNII
3435 RXNORM
2439 MMSL
4903 MMSL
d01105 MMSL
002952 NDDF
387355005 SNOMEDCT_US
64851009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Iodoquinol 1% - Hydrocortisone Acetate 2% - Aloe Polysaccharides 1% HUMAN PRESCRIPTION DRUG LABEL 3 13925-174 GEL 10 mg TOPICAL unapproved drug other 17 sections
hydrocortisone Iodoquinol HUMAN PRESCRIPTION DRUG LABEL 2 45802-930 CREAM 10 mg TOPICAL Unapproved drug other 17 sections
HYDROCORTISONE, IODOQUINOL HUMAN PRESCRIPTION DRUG LABEL 2 52187-532 CREAM 10 mg TOPICAL unapproved drug other 11 sections
IODOQUINOL, HYDROCORTISONE ACETATE, ALOE POLYSACCHARIDES HUMAN PRESCRIPTION DRUG LABEL 3 52187-545 GEL 10 mg TOPICAL unapproved drug other 11 sections
Hydrocortisone Acetate, Iodoquinol HUMAN PRESCRIPTION DRUG LABEL 2 52191-352 CREAM 10 mg TOPICAL unapproved drug other 10 sections
Vytone HUMAN PRESCRIPTION DRUG LABEL 2 57893-302 CREAM 10 mg TOPICAL unapproved drug other 10 sections
Alcortin HUMAN PRESCRIPTION DRUG LABEL 2 68040-702 GEL 1 g TOPICAL unapproved drug other 2 sections
Alcortin A HUMAN PRESCRIPTION DRUG LABEL 3 68040-705 GEL 10 mg TOPICAL UNULLPPROVED OTHER 17 sections
Aloquin HUMAN PRESCRIPTION DRUG LABEL 2 68040-706 GEL 12.50 mg TOPICAL Unapproved other 15 sections
Hydrocortisone Iodoquinol HUMAN PRESCRIPTION DRUG LABEL 2 69367-286 CREAM 10 mg TOPICAL UNULLPPROVED DRUG OTHER 18 sections
ALCORTIN A HUMAN PRESCRIPTION DRUG LABEL 3 69646-705 GEL 10 mg TOPICAL UNULLPPROVED DRUG OTHER 16 sections
QUINJA HUMAN PRESCRIPTION DRUG LABEL 2 69646-716 GEL 12.50 mg TOPICAL UNULLPPROVED DRUG OTHER 14 sections
IODOQUINOL HYDROCORTISONE ACETATE ALOE POLYSACCHARIDES HUMAN PRESCRIPTION DRUG LABEL 3 72056-020 GEL 10 mg TOPICAL UNULLPPROVED DRUG OTHER 17 sections
HYDROCORTISONE IODOQUINOL HUMAN PRESCRIPTION DRUG LABEL 2 72056-040 CREAM 10 mg TOPICAL Unapproved drug other 17 sections
HYDROCORTISONE 2.5% / IODOQUINOL 1% / KETOCONULLZOLE 2% HUMAN PRESCRIPTION DRUG LABEL 3 72934-2111 CREAM 1 g TOPICAL unapproved drug other 4 sections