oxyquinoline Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3290 148-24-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxyquinol
  • 8-hydroxyquinoline
  • 8-Quinolinol
  • oxyquinoline
  • oxyquinoline sulfate
An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.
  • Molecular weight: 145.16
  • Formula: C9H7NO
  • CLOGP: 2.08
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 33.12
  • ALOGS: -1.54
  • ROTB: 0

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
80 mg O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A01AB07 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Antiinfectives and antiseptics for local oral treatment
ATC D08AH03 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quinoline derivatives
ATC G01AC30 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Quinoline derivatives
ATC R02AA14 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
CHEBI has role CHEBI:48218 antiseptic drug
CHEBI has role CHEBI:86328 antifungal agrochemical

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Sensation Disturbance of Genitals contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.78 acidic
pKa2 4.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
72 kDa type IV collagenase Enzyme IC50 3.89 CHEMBL
Methionine aminopeptidase 2 Enzyme IC50 5.69 CHEMBL
Methionine aminopeptidase 1 Enzyme IC50 4.67 CHEMBL
Catechol O-methyltransferase Enzyme IC50 4.67 CHEMBL
Bacterial leucyl aminopeptidase Enzyme Ki 6.80 CHEMBL

External reference:

IDSource
4018497 VUID
N0000146819 NUI
C0000665 UMLSCUI
D02414 KEGG_DRUG
5UTX5635HP UNII
134-31-6 SECONDARY_CAS_RN
77245001 SNOMEDCT_US
34217006 SNOMEDCT_US
4018497 VANDF
110 RXNORM
003184 NDDF
1923 PUBCHEM_CID
CHEBI:48981 CHEBI
CHEMBL310555 ChEMBL_ID
HQI PDB_CHEM_ID
HQY PDB_CHEM_ID
DB11145 DRUGBANK_ID
D015125 MESH_DESCRIPTOR_UI
CHEMBL1697698 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Trimo-San HUMAN PRESCRIPTION DRUG LABEL 2 0295-5030 JELLY 0.25 mg VAGINAL unapproved drug other 5 sections
Fem pH HUMAN PRESCRIPTION DRUG LABEL 2 0813-0799 JELLY 0.00 g VAGINAL unapproved drug other 12 sections
RELEGARD HUMAN PRESCRIPTION DRUG LABEL 2 51674-0130 GEL 0.03 mg TOPICAL unapproved drug other 2 sections
TRIMO SAN HUMAN PRESCRIPTION DRUG LABEL 2 59365-5030 JELLY 0.25 mg VAGINAL UNAPPROVED DRUG OTHER 9 sections