pyridoxine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2836 65-23-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pyridoxine
  • adermin
  • bezatin
  • pirivitol
  • pyridoxin
  • pyridoxine hydrochloride
  • pyridoxine (vit B6)
  • vitamin b6
  • pyridoxine HCl
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
  • Molecular weight: 169.18
  • Formula: C8H11NO3
  • CLOGP: -0.34
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 73.58
  • ALOGS: -1.02
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.16 g O
0.16 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 222 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 39.43 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.66 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.90 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.98 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.204 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.702 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 3.388 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 3.105 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 76.100 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 71.010 % High 1
herg hERG pIC50 4.183 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.014 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.006 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 74.730 % High 1
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,MAP3K21,MAPK7,NTRK2,PDK2,PIK3CB,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1 32
kinase-selectivity-class ACVRL1,BRAF,EPHB4,GRK2,MAP2K6,TGFBR1 6
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.728 High 1
mh-clint Mouse hepatocyte intrinsic clearance 4.102 High 1
mppb Mouse plasma protein binding (% unbound) 87.550 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.102 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 75.810 % High 1
rh-clint Rat hepatocyte intrinsic clearance 2.377 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 88.190 % High 1
rppb Rat plasma protein binding (% unbound) 64.850 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 897.429 uM High 1

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1993 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1590.82 9.97 6478 807893 320386 89493690
Systemic lupus erythematosus 1587.32 9.97 6948 807423 354948 89459128
Glossodynia 1368.95 9.97 6123 808248 315656 89498420
Hand deformity 1120.82 9.97 5450 808921 290912 89523164
Arthropathy 1096.06 9.97 6313 808058 359929 89454147
Abdominal discomfort 1018.33 9.97 7556 806815 469772 89344304
Completed suicide 1018.11 9.97 74 814297 144984 89669092
Alopecia 980.13 9.97 7701 806670 487370 89326706
Wound 921.34 9.97 5246 809125 297734 89516342
Toxicity to various agents 911.35 9.97 749 813622 287097 89526979
Maternal exposure during pregnancy 832.54 9.97 5813 808558 354250 89459826
Synovitis 808.86 9.97 5402 808969 324350 89489726
Anti-cyclic citrullinated peptide antibody positive 766.49 9.97 4166 810205 232267 89581809
Swelling 759.60 9.97 6391 807980 412667 89401409
Pericarditis 753.43 9.97 4573 809798 265578 89548498
Discomfort 681.99 9.97 4510 809861 269825 89544251
Contraindicated product administered 669.77 9.97 5047 809324 315092 89498984
Joint swelling 616.67 9.97 7073 807298 496227 89317849
Duodenal ulcer perforation 606.68 9.97 3730 810641 217558 89596518
Infusion related reaction 598.09 9.97 6046 808325 410734 89403342
Intentional overdose 565.80 9.97 84 814287 93750 89720326
Helicobacter infection 556.10 9.97 3717 810654 223133 89590943
Death 545.79 9.97 2181 812190 454370 89359706
Drug interaction 529.50 9.97 1052 813319 275401 89538675
Rheumatoid arthritis 471.77 9.97 5158 809213 357456 89456620
Pain 449.47 9.97 11917 802454 984424 88829652
Rheumatoid factor positive 445.75 9.97 2854 811517 168796 89645280
Drug abuse 422.44 9.97 109 814262 82238 89731838
Febrile neutropenia 414.28 9.97 487 813884 157862 89656214
Psoriatic arthropathy 412.67 9.97 3482 810889 224853 89589223
Hepatic enzyme increased 385.91 9.97 4943 809428 355793 89458283
Suicide attempt 362.33 9.97 113 814258 75286 89738790
Therapeutic product effect decreased 349.14 9.97 3923 810448 273648 89540428
Depressed level of consciousness 339.31 9.97 115 814256 72669 89741407
Arthralgia 331.52 9.97 9246 805125 769276 89044800
Musculoskeletal stiffness 327.96 9.97 4089 810282 292443 89521633
Impaired healing 325.53 9.97 3377 810994 230822 89583254
Disease progression 324.39 9.97 568 813803 156047 89658029
Malignant neoplasm progression 311.54 9.97 300 814071 106570 89707506
Product use issue 310.85 9.97 4419 809952 325500 89488576
Acute kidney injury 301.45 9.97 1668 812703 318719 89495357
Folliculitis 294.63 9.97 2969 811402 201384 89612692
Overdose 293.35 9.97 610 813761 157099 89656977
Cardiac arrest 292.80 9.97 306 814065 104629 89709447
Neutropenia 283.36 9.97 1051 813320 223853 89590223
Rheumatic fever 275.91 9.97 2334 812037 150787 89663289
Blister 275.34 9.97 3501 810870 251497 89562579
Constipation 266.91 9.97 1454 812917 278941 89535135
Exposure during pregnancy 259.83 9.97 3279 811092 235131 89578945
Drug intolerance 243.12 9.97 5495 808876 442096 89371980
Lactic acidosis 240.01 9.97 77 814294 50386 89763690
Muscle injury 236.31 9.97 2528 811843 174126 89639950
Irritable bowel syndrome 229.35 9.97 2861 811510 204587 89609489
Sleep disorder due to general medical condition, insomnia type 227.26 9.97 1953 812418 126741 89687335
Swollen joint count increased 222.97 9.97 1737 812634 109469 89704607
Hyperhidrosis 219.85 9.97 569 813802 135736 89678340
Sedation 219.56 9.97 79 814292 48092 89765984
Hypotension 217.41 9.97 1873 812498 323524 89490552
Type 2 diabetes mellitus 215.74 9.97 2782 811589 200462 89613614
Nausea 214.29 9.97 7993 806378 1102323 88711753
Fibromyalgia 208.35 9.97 2798 811573 203471 89610605
Hypersensitivity 207.14 9.97 5450 808921 449227 89364849
Treatment failure 206.98 9.97 3859 810512 300069 89514007
Hyponatraemia 205.89 9.97 570 813801 132968 89681108
Nasopharyngitis 204.99 9.97 4946 809425 402158 89411918
Electrocardiogram QT prolonged 204.71 9.97 209 814162 72247 89741829
Blood cholesterol increased 204.11 9.97 2807 811564 205205 89608871
Somnolence 202.89 9.97 1077 813294 208007 89606069
Hip arthroplasty 202.53 9.97 1275 813096 74933 89739143
Knee arthroplasty 201.73 9.97 1360 813011 81822 89732254
Lower respiratory tract infection 191.37 9.97 3241 811130 247418 89566658
Bradycardia 190.54 9.97 286 814085 83561 89730515
Cardiac failure 190.00 9.97 440 813931 109056 89705020
C-reactive protein abnormal 184.79 9.97 1854 812517 125575 89688501
Ill-defined disorder 172.10 9.97 2472 811899 182419 89631657
Agitation 165.29 9.97 216 814155 66882 89747194
Red blood cell sedimentation rate abnormal 160.52 9.97 531 813840 23673 89790403
Renal failure 159.87 9.97 620 813751 130387 89683689
Liver injury 157.75 9.97 2278 812093 168289 89645787
Stomatitis 157.64 9.97 3400 810971 271298 89542778
Cognitive disorder 153.62 9.97 241 814130 69166 89744910
Rhabdomyolysis 151.56 9.97 142 814229 51114 89762962
Myelosuppression 150.92 9.97 155 814216 53436 89760640
Angioedema 149.63 9.97 219 814152 64657 89749419
Sopor 148.67 9.97 22 814349 24622 89789454
Drug reaction with eosinophilia and systemic symptoms 146.99 9.97 102 814269 42656 89771420
Neoplasm progression 146.57 9.97 111 814260 44375 89769701
Osteoarthritis 146.14 9.97 2522 811849 193208 89620868
Syncope 144.43 9.97 656 813715 132007 89682069
Drug ineffective for unapproved indication 142.24 9.97 237 814134 66407 89747669
Hypoglycaemia 142.15 9.97 256 814115 69592 89744484
Contusion 140.81 9.97 3099 811272 248117 89565959
Tremor 139.81 9.97 805 813566 152368 89661708
Renal impairment 138.41 9.97 484 813887 104937 89709139
Respiratory arrest 136.63 9.97 64 814307 33247 89780829
Diarrhoea 136.25 9.97 6976 807395 932214 88881862
Intentional product use issue 136.00 9.97 2720 811651 214172 89599904
Sickle cell anaemia with crisis 135.70 9.97 239 814132 7058 89807018
Coma 134.95 9.97 281 814090 72351 89741725
Chest discomfort 134.02 9.97 713 813658 137652 89676424
No adverse event 133.18 9.97 255 814116 67727 89746349
Thrombocytopenia 132.45 9.97 1217 813154 207508 89606568
Pregnancy 128.70 9.97 977 813394 61070 89753006
Respiratory failure 127.46 9.97 588 813783 117830 89696246
Serotonin syndrome 125.51 9.97 94 814277 37793 89776283
Cardio-respiratory arrest 123.54 9.97 237 814134 62903 89751173
Metabolic acidosis 122.57 9.97 194 814177 55482 89758594
Intentional self-injury 122.43 9.97 55 814316 29279 89784797
Cytokine release syndrome 120.64 9.97 50 814321 27923 89786153
Intentional product misuse 117.88 9.97 411 813960 89193 89724883
Injury 116.17 9.97 2452 811919 194897 89619179
Joint range of motion decreased 115.80 9.97 1787 812584 133856 89680220
Myalgia 115.52 9.97 1011 813360 174114 89639962
Sedation complication 112.36 9.97 11 814360 16933 89797143
Anaemia 111.45 9.97 2369 812002 350433 89463643
Multiple organ dysfunction syndrome 111.13 9.97 284 814087 68052 89746024
Off label use 110.59 9.97 8470 805901 1093782 88720294
Hepatic function abnormal 109.96 9.97 153 814218 46135 89767941
Live birth 109.42 9.97 1140 813231 77967 89736109
General physical health deterioration 108.35 9.97 4056 810315 351059 89463017
COVID-19 108.17 9.97 982 813389 167861 89646215
Tachycardia 107.23 9.97 903 813468 156770 89657306
Facet joint syndrome 106.10 9.97 1351 813020 97038 89717038
Weight increased 105.79 9.97 4679 809692 413248 89400828
Accidental exposure to product 105.77 9.97 135 814236 42231 89771845
Peripheral swelling 105.66 9.97 4630 809741 408476 89405600
Fatigue 105.44 9.97 11873 802498 1142150 88671926
Sinusitis 103.55 9.97 3914 810457 339174 89474902
Hyperglycaemia 103.54 9.97 187 814184 50783 89763293
Altered state of consciousness 103.47 9.97 79 814292 31453 89782623
Device expulsion 103.42 9.97 129 814242 40757 89773319
Palpitations 103.22 9.97 761 813610 135967 89678109
Orthostatic hypotension 102.66 9.97 135 814236 41692 89772384
Balance disorder 102.14 9.97 486 813885 96594 89717482
Grip strength decreased 101.88 9.97 1276 813095 91300 89722776
Inflammation 100.30 9.97 2204 812167 176388 89637688
Vision blurred 99.90 9.97 581 813790 109712 89704364
Blood glucose increased 98.35 9.97 480 813891 94766 89719310
Dyspnoea 98.34 9.97 6707 807664 874248 88939828
Drug resistance 96.50 9.97 79 814292 30370 89783706
Anaphylactic reaction 95.73 9.97 432 813939 87092 89726984
Dry skin 95.56 9.97 436 813935 87637 89726439
Neutrophil count decreased 95.52 9.97 326 814045 71206 89742870
Multiple sclerosis relapse 94.95 9.97 205 814166 52100 89761976
Metastases to bone 94.29 9.97 56 814315 25449 89788627
Abortion spontaneous 94.14 9.97 818 813553 53238 89760838
Food allergy 94.11 9.97 56 814315 25422 89788654
Dehydration 93.96 9.97 1207 813164 193240 89620836
Dysphagia 93.09 9.97 608 813763 111670 89702406
Anaphylactic shock 92.99 9.97 88 814283 31529 89782547
Temperature regulation disorder 92.76 9.97 11 814360 14568 89799508
Hypoxia 92.62 9.97 336 814035 72063 89742013
Hyperkalaemia 92.33 9.97 288 814083 64676 89749400
Hepatocellular injury 91.93 9.97 75 814296 28883 89785193
Macular degeneration 91.71 9.97 124 814247 37846 89776230
Rash 91.15 9.97 8320 806051 787780 89026296
Mobility decreased 89.96 9.97 2918 811453 247816 89566260
Suicidal ideation 89.77 9.97 350 814021 73505 89740571
Creatinine renal clearance decreased 89.58 9.97 29 814342 18870 89795206
Drug withdrawal syndrome 89.20 9.97 76 814295 28647 89785429
Pulmonary fibrosis 88.98 9.97 1409 812962 106094 89707982
Hepatic failure 88.81 9.97 137 814234 39591 89774485
Dysarthria 88.14 9.97 227 814144 54255 89759821
Blood pressure systolic abnormal 88.10 9.97 378 813993 19100 89794976
Blood pressure diastolic abnormal 87.76 9.97 383 813988 19498 89794578
Deep vein thrombosis postoperative 87.58 9.97 998 813373 69811 89744265
Shock 85.94 9.97 79 814292 28699 89785377
Seizure 85.89 9.97 916 813455 151713 89662363
Drug dependence 85.82 9.97 82 814289 29245 89784831
Hallucination 85.78 9.97 304 814067 65655 89748421
Feeling abnormal 85.72 9.97 1025 813346 166210 89647866
Encephalopathy 85.17 9.97 181 814190 46263 89767813
Cytomegalovirus infection 83.09 9.97 70 814301 26532 89787544
Restlessness 82.93 9.97 120 814251 35600 89778476
Wrong technique in product usage process 82.69 9.97 346 814025 71225 89742851
Mydriasis 82.69 9.97 17 814354 14995 89799081
Cardiac failure congestive 82.55 9.97 533 813838 98161 89715915
Condition aggravated 82.37 9.97 6314 808057 589231 89224845
Product dose omission issue 81.25 9.97 1997 812374 289690 89524386
Lip dry 81.23 9.97 1317 813054 99638 89714438
Ventricular tachycardia 80.95 9.97 62 814309 24646 89789430
Skin exfoliation 80.54 9.97 325 814046 67588 89746488
Vomiting 79.69 9.97 6052 808319 782241 89031835
Sepsis 78.65 9.97 1139 813232 178675 89635401
Anxiety 78.02 9.97 2152 812219 307620 89506456
Schizophrenia 77.91 9.97 19 814352 14895 89799181
White blood cell count decreased 77.90 9.97 1045 813326 166064 89648012
Disability assessment scale score increased 77.34 9.97 132 814239 3799 89810277
Infection 75.95 9.97 3980 810391 358114 89455962
Personality disorder 75.32 9.97 11 814360 12433 89801643
Cholestasis 74.79 9.97 132 814239 36167 89777909
Erythema 74.49 9.97 1532 812839 227714 89586362
Joint effusion 73.92 9.97 362 814009 19348 89794728
Back pain 73.69 9.97 2228 812143 314947 89499129
Platelet count decreased 73.09 9.97 832 813539 136137 89677939
Drug level increased 72.96 9.97 85 814286 27677 89786399
Diabetic ketoacidosis 72.88 9.97 67 814304 24340 89789736
Metastases to liver 72.74 9.97 91 814280 28716 89785360
Ejection fraction decreased 72.71 9.97 77 814294 26176 89787900
Respiratory depression 71.90 9.97 25 814346 15550 89798526
Myocardial infarction 71.54 9.97 608 813763 105364 89708712
Blood pressure decreased 70.81 9.97 389 813982 74506 89739570
Foot deformity 70.76 9.97 834 813537 58817 89755259
Blood calcium decreased 70.46 9.97 101 814270 30081 89783995
Asthenia 70.29 9.97 4001 810370 529750 89284326
Obesity 70.08 9.97 1335 813036 104172 89709904
Leukopenia 69.71 9.97 574 813797 100136 89713940
Autoimmune disorder 68.94 9.97 1020 813351 75724 89738352
Cough 68.92 9.97 2664 811707 366298 89447778
Product use in unapproved indication 68.56 9.97 2402 811969 333834 89480242
Arthritis 68.47 9.97 1979 812392 165336 89648740
Foetal exposure during pregnancy 68.03 9.97 637 813734 42338 89771738
Neuropathy peripheral 67.72 9.97 846 813525 136124 89677952
Disturbance in attention 67.54 9.97 208 814163 46901 89767175
Torsade de pointes 67.33 9.97 26 814345 15156 89798920
Cerebral haemorrhage 67.17 9.97 130 814241 34392 89779684
Disorientation 66.70 9.97 190 814181 43924 89770152
Red blood cell sedimentation rate increased 66.63 9.97 1078 813293 81517 89732559
Flushing 66.07 9.97 494 813877 87997 89726079
Wound infection 65.84 9.97 1332 813039 105070 89709006
Extrapyramidal disorder 65.82 9.97 32 814339 16271 89797805
Device difficult to use 65.46 9.97 38 814333 17487 89796589
Gamma-glutamyltransferase increased 65.42 9.97 153 814218 37799 89776277
C-reactive protein increased 65.03 9.97 2111 812260 179278 89634798
Blood pressure systolic increased 64.96 9.97 806 813565 57539 89756537
Fluid retention 64.71 9.97 494 813877 87597 89726479
Disease recurrence 63.94 9.97 153 814218 37500 89776576
Dermatitis atopic 63.72 9.97 70 814301 23402 89790674
Rash erythematous 63.29 9.97 335 814036 64769 89749307
Osteonecrosis of jaw 63.20 9.97 163 814208 38940 89775136
Pulmonary embolism 63.19 9.97 812 813559 130008 89684068
Unresponsive to stimuli 63.08 9.97 157 814214 37964 89776112
Blood creatine phosphokinase increased 62.88 9.97 132 814239 33891 89780185
Aphasia 62.83 9.97 187 814184 42625 89771451
Disseminated intravascular coagulation 62.12 9.97 61 814310 21477 89792599
Thrombotic microangiopathy 61.91 9.97 32 814339 15711 89798365
Loss of consciousness 61.42 9.97 888 813483 139350 89674726
Blood pressure fluctuation 61.37 9.97 731 813640 51682 89762394
Sciatica 61.36 9.97 1265 813106 100117 89713959
Poisoning 61.24 9.97 30 814341 15187 89798889
Hypothermia 60.74 9.97 32 814339 15543 89798533
Posterior reversible encephalopathy syndrome 60.23 9.97 67 814304 22272 89791804
Hypercholesterolaemia 59.79 9.97 1255 813116 99637 89714439
Breast cancer stage III 59.72 9.97 1079 813292 83368 89730708
Joint destruction 59.43 9.97 257 814114 13030 89801046
Hemiparesis 59.18 9.97 123 814248 31696 89782380
Peripheral venous disease 58.89 9.97 1071 813300 82850 89731226
Dislocation of vertebra 58.84 9.97 765 813606 55203 89758873
Eating disorder 57.91 9.97 102 814269 27971 89786105
Musculoskeletal pain 57.81 9.97 1979 812392 169272 89644804
Skin haemorrhage 57.78 9.97 64 814307 21316 89792760
Hemiplegia 57.63 9.97 37 814334 16123 89797953
Carotid artery thrombosis 57.50 9.97 7 814364 9085 89804991
Juvenile idiopathic arthritis 57.50 9.97 117 814254 3860 89810216
Nasal polyps 56.56 9.97 14 814357 10866 89803210
Atrial fibrillation 56.45 9.97 852 813519 132759 89681317
Cerebrovascular accident 56.30 9.97 776 813595 122757 89691319
Metastases to central nervous system 56.23 9.97 45 814326 17497 89796579
Acute hepatic failure 56.21 9.97 72 814299 22489 89791587
Parkinsonism 56.19 9.97 28 814343 14037 89800039
Neurotoxicity 56.12 9.97 66 814305 21401 89792675
Depressed mood 56.05 9.97 246 814125 49976 89764100
Withdrawal syndrome 55.99 9.97 72 814299 22452 89791624
Adjustment disorder with depressed mood 55.64 9.97 766 813605 55987 89758089
Angina pectoris 55.37 9.97 174 814197 38986 89775090
Chronic kidney disease 55.32 9.97 247 814124 49944 89764132
Therapy partial responder 55.27 9.97 70 814301 21973 89792103
Blood alkaline phosphatase increased 55.19 9.97 233 814138 47846 89766230
Palmar-plantar erythrodysaesthesia syndrome 54.98 9.97 105 814266 27918 89786158
Akathisia 54.91 9.97 16 814355 11143 89802933
Blood creatinine increased 54.81 9.97 614 813757 100772 89713304
Blood bilirubin increased 54.77 9.97 203 814168 43267 89770809
Mental status changes 54.77 9.97 211 814160 44468 89769608
Pulmonary oedema 54.63 9.97 330 814041 61750 89752326
Ascites 54.40 9.97 232 814139 47508 89766568
Polyneuropathy 54.38 9.97 56 814315 19285 89794791
Bursitis 54.35 9.97 1559 812812 130095 89683981
Colitis 53.87 9.97 387 813984 69555 89744521
Pain in jaw 53.58 9.97 235 814136 47750 89766326
Dizziness 53.46 9.97 4563 809808 584721 89229355
Tuberculosis 53.30 9.97 239 814132 12310 89801766
Exposure to toxic agent 53.29 9.97 5 814366 7962 89806114
Inappropriate antidiuretic hormone secretion 53.14 9.97 58 814313 19447 89794629
Adverse event 52.86 9.97 1406 812965 116012 89698064
Swollen tongue 52.57 9.97 223 814148 45733 89768343
Polyarthritis 52.51 9.97 313 814058 18037 89796039
Emotional distress 52.47 9.97 162 814209 36500 89777576
Bone erosion 52.13 9.97 716 813655 52305 89761771
Pancreatitis acute 51.80 9.97 134 814237 31981 89782095
Hypokalaemia 51.72 9.97 847 813524 130269 89683807
Miosis 51.70 9.97 11 814360 9473 89804603
Exposure via skin contact 51.50 9.97 16 814355 10689 89803387
Basal cell carcinoma 51.40 9.97 492 813879 32897 89781179
Hypomania 51.29 9.97 9 814362 8888 89805188
Gait inability 51.08 9.97 1699 812672 144757 89669319
Gastrointestinal disorder 50.50 9.97 2805 811566 253882 89560194
Dysgeusia 50.23 9.97 272 814099 52288 89761788
Joint laxity 50.07 9.97 87 814284 2541 89811535
Vertigo 49.63 9.97 395 813976 69416 89744660
Stevens-Johnson syndrome 49.38 9.97 120 814251 29256 89784820
Speech disorder 49.24 9.97 226 814145 45359 89768717
Bone pain 49.19 9.97 340 814031 61643 89752433
Gestational diabetes 49.12 9.97 207 814164 10375 89803701
Second primary malignancy 49.06 9.97 16 814355 10362 89803714
Bronchospasm 48.64 9.97 69 814302 20640 89793436
Road traffic accident 48.52 9.97 1289 813082 106337 89707739
Psychotic disorder 48.33 9.97 133 814238 31097 89782979
Myoclonus 47.93 9.97 61 814310 19107 89794969
Proteinuria 47.71 9.97 85 814286 23206 89790870
Joint stiffness 47.62 9.97 975 813396 77067 89737009
Arrhythmia 47.45 9.97 207 814164 42125 89771951
Adjustment disorder 47.13 9.97 14 814357 9628 89804448
Face oedema 46.96 9.97 86 814285 23232 89790844
Acute respiratory failure 46.82 9.97 212 814159 42706 89771370
Diabetes mellitus inadequate control 46.16 9.97 60 814311 18624 89795452
Respiratory distress 45.78 9.97 187 814184 38759 89775317
Hypomagnesaemia 45.62 9.97 165 814206 35423 89778653
Eye pruritus 45.39 9.97 123 814248 28904 89785172
Caesarean section 44.58 9.97 303 814068 18274 89795802
Alanine aminotransferase increased 44.54 9.97 771 813600 117567 89696509
Eczema 44.47 9.97 285 814086 52585 89761491
Haematotoxicity 44.29 9.97 29 814342 12506 89801570
Abnormal behaviour 44.20 9.97 85 814286 22543 89791533
Headache 44.11 9.97 6944 807427 855802 88958274
Toxic skin eruption 43.98 9.97 46 814325 15728 89798348
Ventricular fibrillation 43.81 9.97 37 814334 14007 89800069
Sleep disorder 43.77 9.97 2188 812183 195842 89618234
Arterial occlusive disease 43.70 9.97 29 814342 12417 89801659
Gastrointestinal haemorrhage 43.64 9.97 560 813811 89688 89724388
Premature labour 43.44 9.97 236 814135 13140 89800936
Coagulopathy 43.34 9.97 90 814281 23199 89790877
Multiple drug therapy 42.88 9.97 6 814365 7003 89807073
Acute generalised exanthematous pustulosis 42.87 9.97 36 814335 13667 89800409
Psoriasis 42.69 9.97 1678 812693 146076 89668000
Pleural effusion 42.68 9.97 728 813643 111263 89702813
Dry mouth 42.64 9.97 2043 812328 182016 89632060
Haemorrhage 42.45 9.97 408 813963 68961 89745115
Rhinitis allergic 42.40 9.97 53 814318 16732 89797344
Muscle twitching 42.17 9.97 97 814274 24105 89789971
Metastases to lung 41.98 9.97 49 814322 15942 89798134
Coordination abnormal 41.91 9.97 80 814291 21276 89792800
Transplant rejection 41.81 9.97 32 814339 12726 89801350
Rebound effect 41.73 9.97 16 814355 9368 89804708
Sensory loss 41.69 9.97 61 814310 18014 89796062
Osteoporosis 41.48 9.97 1149 813222 95382 89718694
Motor dysfunction 41.39 9.97 68 814303 19162 89794914
Lethargy 41.38 9.97 365 814006 62774 89751302
Muscle spasticity 41.27 9.97 170 814201 35152 89778924
Myocarditis 41.10 9.97 38 814333 13768 89800308
Haemophagocytic lymphohistiocytosis 40.98 9.97 47 814324 15412 89798664
Eosinophilia 40.89 9.97 126 814245 28407 89785669
Bronchopulmonary aspergillosis 40.78 9.97 26 814345 11372 89802704
Brain oedema 40.76 9.97 58 814313 17327 89796749
Affect lability 40.65 9.97 62 814309 18001 89796075
Forced expiratory volume decreased 40.62 9.97 3 814368 5805 89808271
Illness 40.61 9.97 506 813865 81463 89732613
Prescribed underdose 40.25 9.97 920 813451 74099 89739977
Hepatotoxicity 40.17 9.97 244 814127 45598 89768478
Cytopenia 40.13 9.97 59 814312 17390 89796686
Tachypnoea 39.95 9.97 82 814289 21227 89792849
Aspartate aminotransferase increased 39.92 9.97 667 813704 102270 89711806
Acute myeloid leukaemia 39.91 9.97 78 814293 20562 89793514
Dyskinesia 39.54 9.97 181 814190 36353 89777723
Graft versus host disease 39.49 9.97 12 814359 8132 89805944
Stress cardiomyopathy 39.48 9.97 37 814334 13318 89800758
Drug tolerance decreased 39.34 9.97 452 813919 31678 89782398
C-reactive protein 39.18 9.97 443 813928 30924 89783152
Loss of personal independence in daily activities 39.15 9.97 1545 812826 134560 89679516
Fall 39.13 9.97 3762 810609 478048 89336028
Aggression 38.76 9.97 117 814254 26551 89787525
Hypothyroidism 38.51 9.97 299 814072 52828 89761248
Melaena 38.49 9.97 171 814200 34626 89779450
Drug dose omission by device 38.48 9.97 22 814349 10209 89803867
Obstructive airways disorder 37.96 9.97 113 814258 25756 89788320
Nightmare 37.91 9.97 87 814284 21638 89792438
Lower limb fracture 37.69 9.97 1016 813355 83997 89730079
Maternal exposure before pregnancy 37.20 9.97 199 814172 11014 89803062
Atrioventricular block complete 37.04 9.97 21 814350 9790 89804286
Anti-cyclic citrullinated peptide antibody 37.02 9.97 391 813980 26830 89787246
Small for dates baby 36.98 9.97 114 814257 4893 89809183
Nodule 36.62 9.97 384 813987 26302 89787774
Lupus-like syndrome 36.27 9.97 629 813742 48217 89765859
Device use error 36.19 9.97 10 814361 7211 89806865
Irritability 36.07 9.97 181 814190 35481 89778595
Neck deformity 36.02 9.97 68 814303 2121 89811955
Hepatic cytolysis 35.99 9.97 149 814222 30767 89783309
Hospitalisation 35.90 9.97 876 813495 127224 89686852
Pulmonary arterial hypertension 35.87 9.97 118 814253 26069 89788007
Haematoma 35.72 9.97 205 814166 38843 89775233
Pain in extremity 35.66 9.97 4596 809775 445933 89368143
Chills 35.51 9.97 908 813463 131073 89683003
Deep vein thrombosis 35.42 9.97 594 813777 91026 89723050
Gangrene 35.40 9.97 38 814333 12838 89801238
International normalised ratio increased 35.38 9.97 264 814107 47052 89767024
Asphyxia 35.29 9.97 10 814361 7093 89806983
Tumour lysis syndrome 35.25 9.97 29 814342 11123 89802953
Injection site reaction 35.18 9.97 1080 813291 91000 89723076
Haemorrhage intracranial 35.13 9.97 51 814320 15111 89798965
Acute graft versus host disease 35.10 9.97 4 814367 5464 89808612
Cerebral infarction 34.96 9.97 122 814249 26474 89787602
Blood pressure diastolic decreased 34.94 9.97 382 813989 26444 89787632
Drug hypersensitivity 34.86 9.97 3640 810731 459969 89354107
Exostosis 34.48 9.97 670 813701 52464 89761612
Aspergillus infection 34.39 9.97 28 814343 10795 89803281
Laryngitis 34.31 9.97 644 813727 50109 89763967
Circulatory collapse 34.27 9.97 112 814259 24792 89789284
X-ray abnormal 34.11 9.97 586 813785 44838 89769238
Lip swelling 34.09 9.97 205 814166 38405 89775671
Mental disorder 33.86 9.97 162 814209 32156 89781920
Hypoaesthesia 33.42 9.97 3268 811103 310942 89503134
Dyspnoea exertional 33.32 9.97 453 813918 71835 89742241
Mania 33.23 9.97 47 814324 14077 89799999
Cardiotoxicity 33.14 9.97 32 814339 11357 89802719
Ischaemic stroke 33.12 9.97 96 814275 22070 89792006
Hallucination, visual 33.07 9.97 102 814269 22990 89791086
Lupus vulgaris 33.01 9.97 579 813792 44480 89769596
Cardiogenic shock 33.01 9.97 111 814260 24357 89789719
Asthma-chronic obstructive pulmonary disease overlap syndrome 32.96 9.97 3 814368 4896 89809180
Tinnitus 32.94 9.97 239 814132 42863 89771213
Neuroleptic malignant syndrome 32.85 9.97 53 814318 15043 89799033
Tardive dyskinesia 32.64 9.97 30 814341 10900 89803176
Disability 32.56 9.97 531 813840 40214 89773862
Retinitis 32.54 9.97 506 813865 37952 89776124
Pseudomonas infection 32.52 9.97 52 814319 14813 89799263
Joint dislocation 32.35 9.97 572 813799 44010 89770066
Substance abuse 32.21 9.97 5 814366 5401 89808675
Bradyphrenia 32.19 9.97 14 814357 7598 89806478
Dystonia 32.14 9.97 64 814307 16755 89797321
Mucosal inflammation 31.93 9.97 347 814024 57278 89756798
Acute graft versus host disease in skin 31.77 9.97 3 814368 4753 89809323
Inappropriate schedule of product administration 31.46 9.97 1067 813304 148866 89665210
Maternal drugs affecting foetus 31.46 9.97 110 814261 5045 89809031
Paralysis 31.41 9.97 34 814337 11444 89802632
Interstitial lung disease 31.31 9.97 490 813881 75915 89738161
Epistaxis 31.26 9.97 557 813814 84568 89729508
Febrile bone marrow aplasia 31.19 9.97 25 814346 9713 89804363
Acute respiratory distress syndrome 31.11 9.97 142 814229 28544 89785532
Status epilepticus 31.02 9.97 78 814293 18796 89795280
Genital haemorrhage 30.93 9.97 20 814351 8682 89805394
Product preparation error 30.84 9.97 28 814343 10233 89803843
Complication of device insertion 30.74 9.97 29 814342 10407 89803669
Skin burning sensation 30.74 9.97 83 814288 19528 89794548
Accidental overdose 30.64 9.97 140 814231 28133 89785943
Erythema multiforme 30.59 9.97 39 814332 12207 89801869
Infusion site pain 30.59 9.97 84 814287 19654 89794422
Multiple fractures 30.57 9.97 168 814203 9394 89804682
Abdominal pain 30.55 9.97 3101 811270 392620 89421456
Clostridium difficile colitis 30.29 9.97 130 814241 26576 89787500
Device related infection 30.19 9.97 124 814247 25662 89788414
Epstein-Barr virus infection 30.17 9.97 29 814342 10315 89803761
Urinary retention 29.96 9.97 207 814164 37537 89776539
Wheelchair user 29.92 9.97 144 814227 7641 89806435
Onychomycosis 29.83 9.97 487 813884 36889 89777187
Product administration error 29.74 9.97 129 814242 26294 89787782
Procedural pain 29.52 9.97 177 814194 33183 89780893
Muscle rigidity 29.51 9.97 52 814319 14257 89799819
Oedema 29.51 9.97 2135 812236 198160 89615916
Ketoacidosis 29.48 9.97 7 814364 5588 89808488
Diabetes mellitus 29.38 9.97 408 813963 64467 89749609
Haemoptysis 29.38 9.97 177 814194 33143 89780933
Ventricular septal defect 29.30 9.97 111 814260 5296 89808780
Pulmonary hypertension 29.13 9.97 243 814128 42280 89771796
Lung disorder 29.09 9.97 1636 812735 148247 89665829
Rheumatoid nodule 29.01 9.97 293 814078 19873 89794203
Heart rate decreased 28.96 9.97 657 813714 52848 89761228
Complication of device removal 28.94 9.97 10 814361 6245 89807831
Infective pulmonary exacerbation of cystic fibrosis 28.63 9.97 30 814341 10249 89803827
Tenderness 28.55 9.97 368 814003 26500 89787576
Rash maculo-papular 28.45 9.97 233 814138 40700 89773376
Cardiomyopathy 28.41 9.97 90 814281 20116 89793960
Pathogen resistance 28.37 9.97 19 814352 8096 89805980
Jaundice cholestatic 28.33 9.97 29 814342 10014 89804062
Panic attack 28.30 9.97 131 814240 26234 89787842
Swelling face 28.10 9.97 538 813833 80814 89733262
Pemphigoid 27.88 9.97 24 814347 9002 89805074
Cytomegalovirus infection reactivation 27.62 9.97 18 814353 7782 89806294
Premature rupture of membranes 27.60 9.97 111 814260 5447 89808629
Jaundice 27.49 9.97 175 814196 32342 89781734
Labelled drug-drug interaction medication error 27.43 9.97 56 814315 14526 89799550
Subarachnoid haemorrhage 27.15 9.97 77 814294 17827 89796249
Dysuria 27.06 9.97 225 814146 39176 89774900
Latent tuberculosis 27.05 9.97 73 814298 2903 89811173
Influenza like illness 26.96 9.97 536 813835 80075 89734001
Hypervolaemia 26.83 9.97 178 814193 32579 89781497
Eye irritation 26.65 9.97 187 814184 33791 89780285
Leukocytosis 26.60 9.97 166 814205 30824 89783252
Hepatic cirrhosis 26.36 9.97 750 813621 62503 89751573
Pulmonary congestion 26.32 9.97 88 814283 19345 89794731
Sleep apnoea syndrome 26.26 9.97 172 814199 31575 89782501
Hypophagia 26.17 9.97 202 814169 35735 89778341
Delusion 26.16 9.97 53 814318 13787 89800289
Product prescribing error 26.12 9.97 161 814210 29984 89784092
Incorrect dose administered 26.05 9.97 526 813845 78404 89735672
Urinary incontinence 26.04 9.97 214 814157 37352 89776724
Lymphocyte count decreased 26.00 9.97 196 814175 34854 89779222
Nervousness 25.95 9.97 189 814182 33867 89780209
Blepharospasm 25.83 9.97 667 813704 54778 89759298
Respiratory acidosis 25.81 9.97 21 814350 8098 89805978
Eosinophil count increased 25.67 9.97 49 814322 13032 89801044
Onychomadesis 25.58 9.97 567 813804 45431 89768645
Hot flush 25.58 9.97 378 813993 59110 89754966
Lymphopenia 25.58 9.97 112 814259 22769 89791307
Tubulointerstitial nephritis 25.42 9.97 129 814242 25214 89788862
Colitis microscopic 25.40 9.97 38 814333 11121 89802955
Multiple allergies 25.36 9.97 62 814309 15084 89798992
Anuria 25.33 9.97 60 814311 14758 89799318
Psychomotor hyperactivity 25.14 9.97 48 814323 12765 89801311
Cyanosis 25.07 9.97 90 814281 19365 89794711
Product prescribing issue 24.91 9.97 21 814350 7958 89806118
Fear 24.83 9.97 72 814299 16550 89797526
Dysphonia 24.71 9.97 408 813963 62676 89751400
Smear cervix abnormal 24.58 9.97 73 814298 3069 89811007
Acute chest syndrome 24.53 9.97 40 814331 1108 89812968
Sinus disorder 24.44 9.97 195 814176 34252 89779824
Dysmorphism 24.36 9.97 64 814307 2504 89811572
Sinus tachycardia 24.34 9.97 153 814218 28360 89785716
Blood glucose decreased 24.22 9.97 118 814253 23311 89790765
Schizoaffective disorder 24.21 9.97 8 814363 5139 89808937
Aspiration 24.16 9.97 67 814304 15626 89798450
Graft versus host disease in gastrointestinal tract 24.11 9.97 5 814366 4383 89809693
Pericardial effusion 24.10 9.97 213 814158 36620 89777456
Glomerular filtration rate decreased 24.10 9.97 75 814296 16857 89797219
Breast cancer female 24.09 9.97 62 814309 14824 89799252
Acute myocardial infarction 24.07 9.97 199 814172 34691 89779385
Blood urea increased 24.04 9.97 167 814204 30246 89783830
Renal tubular necrosis 24.04 9.97 60 814311 14495 89799581
Presyncope 24.00 9.97 177 814194 31628 89782448
Limb deformity 23.97 9.97 87 814284 4065 89810011
Paranoia 23.92 9.97 50 814321 12858 89801218
Atrial septal defect 23.91 9.97 141 814230 8093 89805983
Blood pressure diastolic increased 23.89 9.97 198 814173 12708 89801368
Acidosis 23.88 9.97 49 814322 12687 89801389
Pulmonary alveolar haemorrhage 23.87 9.97 12 814359 5986 89808090
Device dislocation 23.85 9.97 175 814196 31307 89782769
Pulseless electrical activity 23.85 9.97 27 814344 8905 89805171
Gastroenteritis viral 23.66 9.97 394 813977 29961 89784115
Cytomegalovirus viraemia 23.64 9.97 20 814351 7566 89806510
Body temperature decreased 23.57 9.97 322 814049 23494 89790582
Heart rate increased 23.56 9.97 804 813567 112098 89701978
Enthesopathy 23.54 9.97 155 814216 9249 89804827
Pallor 23.51 9.97 195 814176 33970 89780106
Sinus bradycardia 23.49 9.97 76 814295 16876 89797200
Sexual dysfunction 23.43 9.97 7 814364 4797 89809279
Oliguria 23.40 9.97 37 814334 10587 89803489
Electrocardiogram QRS complex prolonged 23.36 9.97 19 814352 7329 89806747
Hyperlipidaemia 23.35 9.97 116 814255 22800 89791276
Generalised oedema 23.34 9.97 90 814281 18963 89795113
Middle insomnia 23.28 9.97 75 814296 16676 89797400
Systemic inflammatory response syndrome 23.13 9.97 15 814356 6501 89807575
Device breakage 23.11 9.97 58 814313 13986 89800090
Dissociation 23.10 9.97 16 814355 6699 89807377
Complication associated with device 23.10 9.97 93 814278 19356 89794720
Agranulocytosis 23.09 9.97 202 814169 34800 89779276
Polyuria 23.04 9.97 34 814337 10006 89804070
Purpura 22.82 9.97 63 814308 14715 89799361
Glycosylated haemoglobin increased 22.81 9.97 68 814303 15494 89798582
Sneezing 22.64 9.97 166 814205 29703 89784373
Treatment noncompliance 22.48 9.97 328 814043 51399 89762677
Blood potassium decreased 22.39 9.97 298 814073 47429 89766647
Malignant mediastinal neoplasm 22.26 9.97 43 814328 1365 89812711
Skin toxicity 22.22 9.97 17 814354 6762 89807314
Chronic graft versus host disease 22.16 9.97 5 814366 4134 89809942
Rotator cuff repair 22.11 9.97 60 814311 2394 89811682
Seronegative arthritis 22.09 9.97 256 814115 17978 89796098
Ankylosing spondylitis 21.96 9.97 197 814174 12936 89801140
Metastases to lymph nodes 21.89 9.97 45 814326 11644 89802432
Hallucination, auditory 21.87 9.97 72 814299 15903 89798173
Asthma 21.76 9.97 1876 812495 240284 89573792
Mucormycosis 21.74 9.97 4 814367 3817 89810259
Ileus 21.68 9.97 76 814295 16470 89797606
Hallucinations, mixed 21.67 9.97 13 814358 5876 89808200
Paraesthesia oral 21.65 9.97 181 814190 31478 89782598
Total lung capacity increased 21.61 9.97 9 814362 5012 89809064
Bacteraemia 21.53 9.97 115 814256 22185 89791891
Right ventricular failure 21.47 9.97 94 814277 19111 89794965
Rales 21.21 9.97 72 814299 15755 89798321
Synovial disorder 21.21 9.97 69 814302 3049 89811027
Systemic candida 21.17 9.97 9 814362 4950 89809126
Developmental hip dysplasia 21.01 9.97 45 814326 1540 89812536
Therapy interrupted 20.99 9.97 320 814051 49788 89764288
Atrial tachycardia 20.97 9.97 14 814357 5976 89808100
Respiratory tract congestion 20.94 9.97 152 814219 27258 89786818
Sputum discoloured 20.91 9.97 103 814268 20288 89793788
Sleep terror 20.89 9.97 7 814364 4457 89809619
Ear infection 20.75 9.97 795 813576 68980 89745096
Klebsiella infection 20.71 9.97 38 814333 10259 89803817
Insurance issue 20.68 9.97 42 814329 10916 89803160
Crying 20.68 9.97 140 814231 25505 89788571
Maternal exposure timing unspecified 20.65 9.97 300 814071 22183 89791893
Bradypnoea 20.62 9.97 8 814363 4650 89809426
Transaminases increased 20.59 9.97 224 814147 36968 89777108
Rheumatoid lung 20.42 9.97 82 814289 4021 89810055
Toxic encephalopathy 20.41 9.97 29 814342 8670 89805406
Hypernatraemia 20.38 9.97 33 814338 9354 89804722
Adenovirus infection 20.36 9.97 8 814363 4614 89809462
Respiration abnormal 20.27 9.97 25 814346 7938 89806138
Head injury 20.13 9.97 181 814190 31007 89783069
Atrioventricular block 20.08 9.97 30 814341 8785 89805291
Antinuclear antibody positive 20.00 9.97 147 814224 9094 89804982
Myopathy 19.87 9.97 59 814312 13459 89800617
Infusion site erythema 19.85 9.97 60 814311 13610 89800466
Drug tolerance 19.72 9.97 247 814124 17669 89796407
Pre-eclampsia 19.66 9.97 168 814203 10880 89803196
Nail operation 19.64 9.97 49 814322 1857 89812219
Hypophosphataemia 19.62 9.97 68 814303 14786 89799290
Renal injury 19.56 9.97 39 814332 10204 89803872
Body height below normal 19.53 9.97 53 814318 2115 89811961
Immune effector cell-associated neurotoxicity syndrome 19.51 9.97 14 814357 5754 89808322
Breast cancer metastatic 19.50 9.97 70 814301 15062 89799014
Stillbirth 19.44 9.97 124 814247 7319 89806757
Therapeutic response shortened 19.41 9.97 123 814248 22756 89791320
Localised infection 19.39 9.97 416 813955 33146 89780930
Placental disorder 19.39 9.97 44 814327 1567 89812509
Night sweats 19.37 9.97 1375 812996 127391 89686685
Chronic obstructive pulmonary disease 19.30 9.97 510 813861 73319 89740757
Product storage error 19.20 9.97 105 814266 20136 89793940
Diabetes insipidus 19.07 9.97 3 814368 3209 89810867
Product administered to patient of inappropriate age 18.99 9.97 9 814362 4644 89809432
Immune reconstitution inflammatory syndrome 18.98 9.97 21 814350 6998 89807078
Transplant dysfunction 18.96 9.97 12 814359 5270 89808806
Subdural haematoma 18.89 9.97 81 814290 16564 89797512
Tenosynovitis stenosans 18.88 9.97 78 814293 3875 89810201
Neck mass 18.85 9.97 77 814294 3805 89810271
Synovial fluid analysis 18.84 9.97 62 814309 2756 89811320
Product administration interrupted 18.74 9.97 54 814317 12438 89801638
Hepatitis acute 18.67 9.97 44 814327 10843 89803233
Multiple sclerosis 18.66 9.97 160 814211 27680 89786396
Hyperprolactinaemia 18.62 9.97 13 814358 5420 89808656
Epidermal necrosis 18.61 9.97 55 814316 2306 89811770
Euglycaemic diabetic ketoacidosis 18.54 9.97 17 814354 6184 89807892
Pulmonary haemorrhage 18.52 9.97 27 814344 7986 89806090
Hyperlactacidaemia 18.48 9.97 7 814364 4129 89809947
Clostridium test positive 18.41 9.97 13 814358 5388 89808688
Device issue 18.38 9.97 173 814198 29364 89784712
Enterocolitis 18.31 9.97 42 814329 10448 89803628
Acute coronary syndrome 18.31 9.97 44 814327 10769 89803307
Hyperuricaemia 18.28 9.97 20 814351 6699 89807377
Device leakage 18.26 9.97 39 814332 9952 89804124
Spinal stenosis 18.24 9.97 238 814133 17186 89796890
Blindness 18.12 9.97 152 814219 26416 89787660
Nystagmus 18.07 9.97 23 814348 7204 89806872
Pseudomonal sepsis 18.06 9.97 8 814363 4294 89809782
Product adhesion issue 18.03 9.97 12 814359 5130 89808946
Pyrexia 17.95 9.97 5481 808890 655004 89159072
Wheezing 17.95 9.97 2422 811949 235658 89578418
Laryngospasm 17.90 9.97 4 814367 3329 89810747
Salivary hypersecretion 17.89 9.97 34 814337 9058 89805018
Progressive multifocal leukoencephalopathy 17.88 9.97 76 814295 15579 89798497
Foetal anticonvulsant syndrome 17.85 9.97 26 814345 651 89813425
Urinary tract infection 17.82 9.97 2440 811931 303192 89510884
Finger deformity 17.82 9.97 404 813967 32493 89781583
Visual acuity reduced 17.80 9.97 130 814241 23280 89790796
Red blood cell sedimentation rate 17.79 9.97 86 814285 4572 89809504
Throat tightness 17.79 9.97 174 814197 29310 89784766
Hepatic necrosis 17.70 9.97 19 814352 6419 89807657
Bone lesion 17.69 9.97 19 814352 6418 89807658
Loose body in joint 17.67 9.97 39 814332 1363 89812713
Hyperbilirubinaemia 17.61 9.97 65 814306 13871 89800205
Pulmonary tuberculosis 17.57 9.97 88 814283 4746 89809330
Potentiating drug interaction 17.56 9.97 15 814356 5647 89808429
Blood pressure inadequately controlled 17.52 9.97 18 814353 6206 89807870
Polyhydramnios 17.51 9.97 56 814315 2452 89811624
Lymphoedema 17.47 9.97 64 814307 13689 89800387
Blood lactate dehydrogenase increased 17.40 9.97 149 814222 25783 89788293
Injection site pruritus 17.37 9.97 619 813752 53215 89760861
Palmoplantar keratoderma 17.31 9.97 5 814366 3502 89810574
Sleep disorder due to a general medical condition 17.30 9.97 290 814081 44448 89769628
Hepatitis B reactivation 17.30 9.97 7 814364 3967 89810109
Hypoglycaemic coma 17.29 9.97 3 814368 2987 89811089
Pharyngeal swelling 17.21 9.97 40 814331 9904 89804172
Injection site erythema 17.17 9.97 1065 813306 97437 89716639
Laryngeal oedema 17.10 9.97 22 814349 6859 89807217
Rhinovirus infection 17.07 9.97 17 814354 5946 89808130
Cleft lip and palate 17.05 9.97 27 814344 729 89813347
Acute pulmonary oedema 17.01 9.97 38 814333 9542 89804534
Vascular device infection 16.97 9.97 53 814318 11899 89802177
Shock haemorrhagic 16.89 9.97 55 814316 12190 89801886
Hypermethioninaemia 16.87 9.97 9 814362 51 89814025
Coronary artery disease 16.86 9.97 207 814164 33416 89780660
Hypogammaglobulinaemia 16.86 9.97 45 814326 10629 89803447
Pruritus genital 16.86 9.97 10 814361 4548 89809528
Immune-mediated enterocolitis 16.82 9.97 11 814360 4746 89809330
Post-traumatic stress disorder 16.79 9.97 22 814349 6806 89807270
Malaise 16.79 9.97 4852 809519 581134 89232942
Troponin increased 16.74 9.97 62 814309 13219 89800857
Arthritis infective 16.65 9.97 126 814245 7866 89806210
Bradykinesia 16.56 9.97 22 814349 6766 89807310
Prescribed overdose 16.56 9.97 1053 813318 96572 89717504
Tenosynovitis 16.54 9.97 202 814169 14365 89799711
Walking aid user 16.50 9.97 427 813944 35079 89778997
Postoperative wound infection 16.49 9.97 189 814182 13237 89800839
Cholelithiasis 16.41 9.97 353 814018 52153 89761923
Haematemesis 16.40 9.97 209 814162 33517 89780559
Maternal exposure during delivery 16.38 9.97 7 814364 3839 89810237
Dyspepsia 16.35 9.97 2027 812344 196133 89617943
Chronic sinusitis 16.31 9.97 136 814235 23666 89790410
Diplopia 16.27 9.97 172 814199 28542 89785534
Body temperature increased 16.27 9.97 293 814078 44417 89769659
Lacrimation increased 16.20 9.97 160 814211 26902 89787174
Device malfunction 16.18 9.97 116 814255 20861 89793215
Skin papilloma 16.09 9.97 96 814275 5534 89808542
Ankle arthroplasty 16.07 9.97 59 814312 2772 89811304
Amyloid arthropathy 16.07 9.97 42 814329 1638 89812438
Anhedonia 16.01 9.97 51 814320 11380 89802696
Hyperthermia 16.00 9.97 44 814327 10291 89803785
Product dose omission in error 16.00 9.97 113 814258 20390 89793686
Anosmia 15.95 9.97 41 814330 9807 89804269
Bundle branch block left 15.95 9.97 29 814342 7856 89806220
Hereditary angioedema 15.94 9.97 38 814333 9327 89804749
Infusion site swelling 15.92 9.97 53 814318 11667 89802409
Femur fracture 15.90 9.97 534 813837 45548 89768528
Anti-neutrophil cytoplasmic antibody positive vasculitis 15.88 9.97 8 814363 3985 89810091
Haematochezia 15.74 9.97 501 813870 70412 89743664
Product substitution issue 15.70 9.97 96 814275 17912 89796164
Congenital arterial malformation 15.61 9.97 17 814354 314 89813762
Septic shock 15.60 9.97 608 813763 83552 89730524
Dermatitis exfoliative 15.60 9.97 16 814355 5520 89808556
Extra dose administered 15.52 9.97 37 814334 9081 89804995
Cardiac failure acute 15.49 9.97 55 814316 11874 89802202
Blood lactic acid increased 15.44 9.97 35 814336 8743 89805333
Human antichimeric antibody positive 15.43 9.97 43 814328 1743 89812333
Cardiac disorder 15.36 9.97 391 813980 56481 89757595
Reversible cerebral vasoconstriction syndrome 15.36 9.97 9 814362 4121 89809955
Haemodynamic instability 15.33 9.97 54 814317 11685 89802391
Generalised tonic-clonic seizure 15.28 9.97 221 814150 34682 89779394
Nail disorder 15.26 9.97 663 813708 58404 89755672
Bezoar 15.26 9.97 3 814368 2731 89811345
Brain injury 15.17 9.97 29 814342 7709 89806367
Synovial cyst 15.14 9.97 167 814204 11585 89802491
Renal disorder 15.11 9.97 244 814127 37615 89776461
Bundle branch block right 15.09 9.97 16 814355 5437 89808639
Antibody test positive 15.09 9.97 60 814311 2929 89811147
Pneumatosis intestinalis 15.05 9.97 6 814365 3431 89810645
Haematuria 15.02 9.97 222 814149 34715 89779361
Spondylitis 14.98 9.97 194 814177 13984 89800092
Limb reduction defect 14.96 9.97 23 814348 605 89813471
Pain of skin 14.94 9.97 84 814287 15998 89798078
Feeding disorder 14.93 9.97 94 814277 17418 89796658
Pneumonia viral 14.86 9.97 36 814335 8787 89805289
Blood phosphorus decreased 14.82 9.97 14 814357 5020 89809056
Impaired gastric emptying 14.74 9.97 62 814309 12747 89801329
Dementia 14.74 9.97 140 814231 23721 89790355
Epstein-Barr virus associated lymphoproliferative disorder 14.73 9.97 3 814368 2664 89811412
Long QT syndrome 14.73 9.97 9 814362 4028 89810048
Mood altered 14.63 9.97 92 814279 17052 89797024
Temperature intolerance 14.62 9.97 57 814314 11973 89802103
Clear cell renal cell carcinoma 14.61 9.97 39 814332 1541 89812535
Abortion incomplete 14.56 9.97 5 814366 3135 89810941
Malignant melanoma 14.54 9.97 175 814196 12401 89801675
Therapy non-responder 14.54 9.97 1422 812949 135282 89678794
Hypertelorism 14.50 9.97 21 814350 523 89813553
Infusion site pruritus 14.49 9.97 24 814347 6741 89807335
Lymphatic fistula 14.47 9.97 37 814334 1424 89812652
Bone marrow failure 14.46 9.97 203 814168 32018 89782058
Nasal oedema 14.40 9.97 105 814266 6479 89807597
Cholecystitis chronic 14.36 9.97 43 814328 9783 89804293
Hyperpyrexia 14.30 9.97 13 814358 4748 89809328
Hyperthyroidism 14.25 9.97 101 814270 18209 89795867
Dermatitis acneiform 14.12 9.97 22 814349 6332 89807744
Tetany 14.08 9.97 3 814368 2581 89811495
Myocardial ischaemia 14.03 9.97 70 814301 13744 89800332
Trigeminal neuralgia 14.01 9.97 10 814361 4121 89809955
Breast feeding 14.00 9.97 27 814344 856 89813220
Nocardiosis 13.97 9.97 3 814368 2567 89811509
Facial paralysis 13.97 9.97 82 814289 15452 89798624
Amenorrhoea 13.96 9.97 56 814315 11666 89802410
Retrognathia 13.92 9.97 21 814350 543 89813533
Immune thrombocytopenia 13.84 9.97 67 814304 13259 89800817
Hyperammonaemia 13.84 9.97 23 814348 6452 89807624
Endophthalmitis 13.82 9.97 13 814358 4672 89809404
Neutrophilia 13.82 9.97 19 814352 5759 89808317
Impaired quality of life 13.79 9.97 137 814234 23007 89791069
Product residue present 13.76 9.97 11 814360 4280 89809796
Scleritis 13.75 9.97 87 814284 5121 89808955
Mouth ulceration 13.74 9.97 463 813908 39511 89774565
Femoral hernia incarcerated 13.72 9.97 37 814334 1471 89812605
Atrial flutter 13.71 9.97 50 814321 10708 89803368
Catheter site pain 13.70 9.97 18 814353 5561 89808515
Haemorrhage in pregnancy 13.66 9.97 47 814324 2138 89811938
Eosinophilic granulomatosis with polyangiitis 13.66 9.97 3 814368 2527 89811549
Nephropathy toxic 13.64 9.97 63 814308 12625 89801451
Nasal obstruction 13.64 9.97 53 814318 2559 89811517
Staphylococcal infection 13.63 9.97 331 814040 48108 89765968
Device physical property issue 13.62 9.97 4 814367 2772 89811304
Electrolyte imbalance 13.55 9.97 142 814229 23603 89790473
Increased appetite 13.51 9.97 57 814314 11708 89802368
Pneumonitis 13.50 9.97 298 814073 43872 89770204
Type 1 diabetes mellitus 13.45 9.97 14 814357 4798 89809278
Bone density increased 13.45 9.97 27 814344 882 89813194
Loss of employment 13.44 9.97 5 814366 2982 89811094
Amylase increased 13.44 9.97 27 814344 7045 89807031
Choking 13.39 9.97 59 814312 11974 89802102
Polydipsia 13.38 9.97 11 814360 4220 89809856
Blood test abnormal 13.34 9.97 122 814249 20830 89793246
Back injury 13.34 9.97 529 813842 46093 89767983
Incoherent 13.34 9.97 15 814356 4962 89809114
Cystitis haemorrhagic 13.32 9.97 18 814353 5495 89808581
Abdominal distension 13.22 9.97 1002 813369 129599 89684477
Fracture delayed union 13.21 9.97 51 814320 2455 89811621
Plasma cell myeloma 13.20 9.97 273 814098 40555 89773521
Candida infection 13.09 9.97 221 814150 33836 89780240
Wound infection pseudomonas 13.07 9.97 44 814327 1979 89812097
Cervical incompetence 13.07 9.97 22 814349 626 89813450
Affective disorder 12.97 9.97 32 814339 7761 89806315
Device deployment issue 12.93 9.97 15 814356 4894 89809182
Metastasis 12.93 9.97 22 814349 6115 89807961
Neuralgia 12.91 9.97 202 814169 31298 89782778
Catheter site erythema 12.84 9.97 15 814356 4879 89809197
Osteolysis 12.84 9.97 8 814363 3542 89810534
Premature delivery 12.83 9.97 447 813924 38315 89775761
Needle issue 12.83 9.97 73 814298 13861 89800215
Crohn's disease 12.78 9.97 81 814290 4770 89809306
Speech disorder developmental 12.76 9.97 27 814344 916 89813160
Respiratory disorder 12.73 9.97 465 813906 64351 89749725
Immunosuppressant drug level increased 12.66 9.97 14 814357 4666 89809410
Short stature 12.63 9.97 29 814342 1041 89813035
Osteonecrosis 12.62 9.97 163 814208 26078 89787998
Device use issue 12.57 9.97 9 814362 3704 89810372
Pulmonary toxicity 12.55 9.97 57 814314 11474 89802602
Gastroschisis 12.42 9.97 17 814354 401 89813675
Foetal heart rate abnormal 12.40 9.97 27 814344 935 89813141
Exomphalos 12.39 9.97 20 814351 549 89813527
Blood loss anaemia 12.35 9.97 48 814323 10092 89803984
Pneumonia bacterial 12.32 9.97 66 814305 12724 89801352
Skin plaque 12.29 9.97 47 814324 9928 89804148
Unevaluable event 12.29 9.97 387 813984 54461 89759615
Neoplasm recurrence 12.27 9.97 7 814364 3252 89810824
Pathological fracture 12.24 9.97 45 814326 9615 89804461
Intestinal ischaemia 12.19 9.97 40 814331 8843 89805233
Heparin-induced thrombocytopenia 12.18 9.97 18 814353 5294 89808782
Pancreatitis 12.18 9.97 508 813863 69318 89744758
Nail injury 12.16 9.97 24 814347 774 89813302
Skin ulcer 12.05 9.97 558 813813 49517 89764559
Blood sodium decreased 12.03 9.97 175 814196 27438 89786638
Inadequate analgesia 12.03 9.97 7 814364 3217 89810859
Hypokinesia 12.01 9.97 87 814284 15610 89798466
Liver disorder 11.96 9.97 1255 813116 120014 89694062
Intervertebral disc degeneration 11.96 9.97 220 814151 17054 89797022
Iritis 11.95 9.97 65 814306 3621 89810455
Thrombosis 11.93 9.97 537 813834 72714 89741362
Persecutory delusion 11.92 9.97 7 814364 3201 89810875
Intraocular pressure increased 11.90 9.97 29 814342 7064 89807012
Ventricular extrasystoles 11.88 9.97 70 814301 13180 89800896
Sensitisation 11.84 9.97 12 814359 4163 89809913
Retinal haemorrhage 11.84 9.97 21 814350 5743 89808333
Uterine perforation 11.82 9.97 32 814339 7522 89806554
Exercise tolerance decreased 11.80 9.97 32 814339 7519 89806557
Pregnancy with contraceptive device 11.78 9.97 17 814354 5049 89809027
Pancreatic steatosis 11.77 9.97 37 814334 1605 89812471
Subacute cutaneous lupus erythematosus 11.72 9.97 9 814362 3573 89810503
Type I hypersensitivity 11.72 9.97 12 814359 4143 89809933
Thirst 11.67 9.97 92 814279 16203 89797873
Pulmonary function test abnormal 11.64 9.97 5 814366 2734 89811342
Drug screen positive 11.59 9.97 10 814361 3747 89810329
Kidney transplant rejection 11.59 9.97 16 814355 4841 89809235
Paranasal sinus discomfort 11.55 9.97 24 814347 6186 89807890
Induced labour 11.55 9.97 27 814344 981 89813095
Psychotic symptom 11.54 9.97 3 814368 2253 89811823
Metastases to spine 11.51 9.97 10 814361 3733 89810343
Rash macular 11.48 9.97 197 814174 30083 89783993
Lipase increased 11.46 9.97 56 814315 11055 89803021
Hypercapnia 11.44 9.97 27 814344 6650 89807426
Cerebral haematoma 11.41 9.97 13 814358 4276 89809800
Benign ovarian tumour 11.39 9.97 18 814353 485 89813591
Carotid artery occlusion 11.39 9.97 25 814346 6317 89807759
Ventricular hypokinesia 11.39 9.97 19 814352 5322 89808754
Wrong technique in device usage process 11.33 9.97 22 814349 5813 89808263
Drug effective for unapproved indication 11.32 9.97 35 814336 7883 89806193
Virologic failure 11.30 9.97 3 814368 2221 89811855
Product physical issue 11.29 9.97 21 814350 5639 89808437
Device occlusion 11.27 9.97 44 814327 9238 89804838
Colorectal cancer 11.26 9.97 11 814360 3882 89810194
Ingrown hair 11.25 9.97 20 814351 595 89813481
Abdominal pain lower 11.22 9.97 197 814174 29980 89784096
Formication 11.22 9.97 16 814355 4775 89809301
Immunisation 11.21 9.97 3 814368 2210 89811866
Congenital cerebral cyst 11.21 9.97 13 814358 258 89813818
Eye swelling 11.20 9.97 191 814180 29195 89784881
Tumour marker increased 11.18 9.97 22 814349 5785 89808291
Varicella zoster virus infection 11.16 9.97 11 814360 3866 89810210
Productive cough 11.16 9.97 572 813799 76491 89737585
Cyst 11.14 9.97 210 814161 16351 89797725
International normalised ratio fluctuation 11.14 9.97 7 814364 3086 89810990
Product availability issue 11.11 9.97 32 814339 7372 89806704
Oligoarthritis 11.08 9.97 19 814352 549 89813527
Erythema of eyelid 11.06 9.97 8 814363 3275 89810801
Congenital anomaly 11.02 9.97 96 814275 6251 89807825
Abortion missed 11.00 9.97 41 814330 1941 89812135
Cross sensitivity reaction 10.95 9.97 6 814365 2851 89811225
Foetal distress syndrome 10.94 9.97 37 814334 1668 89812408
Ulcer haemorrhage 10.94 9.97 312 814059 26009 89788067
Joint lock 10.94 9.97 49 814322 2523 89811553
Haemodialysis 10.92 9.97 41 814330 8706 89805370
Cushingoid 10.89 9.97 142 814229 10253 89803823
Cell death 10.89 9.97 7 814364 3048 89811028
Full blood count abnormal 10.88 9.97 248 814123 36349 89777727
Pneumonia fungal 10.84 9.97 30 814341 7001 89807075
Hypoalbuminaemia 10.82 9.97 91 814280 15806 89798270
Central nervous system lesion 10.73 9.97 61 814310 11585 89802491
Bronchial secretion retention 10.70 9.97 10 814361 3605 89810471
Cleft palate 10.70 9.97 31 814340 1285 89812791
Terminal state 10.68 9.97 6 814365 2812 89811264
Eye movement disorder 10.67 9.97 25 814346 6173 89807903
Human anti-human antibody test 10.66 9.97 16 814355 412 89813664
Sickle cell anaemia 10.63 9.97 20 814351 622 89813454
Learning disorder 10.59 9.97 24 814347 854 89813222
Gene mutation 10.58 9.97 3 814368 2127 89811949
Inflammatory marker increased 10.56 9.97 128 814243 9086 89804990
Skin weeping 10.56 9.97 6 814365 2794 89811282
Monoclonal immunoglobulin present 10.54 9.97 3 814368 2121 89811955
Pruritus 10.49 9.97 4551 809820 536974 89277102
Staphylococcal sepsis 10.44 9.97 46 814325 9337 89804739
Shortened cervix 10.43 9.97 12 814359 236 89813840
Injection site warmth 10.41 9.97 218 814153 17297 89796779
Pneumothorax 10.38 9.97 116 814255 19051 89795025
Talipes 10.38 9.97 36 814335 1644 89812432
Coprolalia 10.37 9.97 5 814366 22 89814054
Lip oedema 10.37 9.97 16 814355 4623 89809453
Skin cancer 10.36 9.97 175 814196 13344 89800732
Cardiac failure chronic 10.35 9.97 22 814349 5624 89808452
Butterfly rash 10.34 9.97 43 814328 2142 89811934
Cyst rupture 10.34 9.97 23 814348 808 89813268
Dependence 10.32 9.97 3 814368 2092 89811984
Adverse drug reaction 10.31 9.97 1199 813172 115502 89698574
Cardiac tamponade 10.28 9.97 22 814349 5610 89808466
Skin disorder 10.28 9.97 251 814120 36455 89777621
Ventricular dysfunction 10.27 9.97 11 814360 3720 89810356
Micturition urgency 10.26 9.97 59 814312 11174 89802902
Ataxia 10.25 9.97 108 814263 17934 89796142
Eyelid haemangioma 10.25 9.97 4 814367 9 89814067
Neutrophil count increased 10.25 9.97 118 814253 19272 89794804
Embolism 10.24 9.97 47 814324 9434 89804642
Joint warmth 10.24 9.97 37 814334 1725 89812351
Secondary adrenocortical insufficiency 10.23 9.97 4 814367 2314 89811762
Acute graft versus host disease in intestine 10.23 9.97 3 814368 2080 89811996
Hemianopia 10.22 9.97 3 814368 2079 89811997
Pharyngeal oedema 10.22 9.97 77 814294 13694 89800382
Lung opacity 10.20 9.97 25 814346 6077 89807999
Tension headache 10.17 9.97 34 814337 7475 89806601
Immune-mediated hepatitis 10.15 9.97 7 814364 2937 89811139
Cutaneous vasculitis 10.14 9.97 32 814339 7161 89806915
Embedded device 10.13 9.97 14 814357 4234 89809842
Hepatitis cholestatic 10.13 9.97 41 814330 8520 89805556
Major depression 10.11 9.97 51 814320 9984 89804092
Oedema peripheral 10.09 9.97 2105 812266 255810 89558266
Dialysis 10.08 9.97 60 814311 11269 89802807
Ageusia 10.07 9.97 94 814277 15982 89798094
Upper respiratory tract irritation 10.07 9.97 11 814360 204 89813872
Skin lesion 10.06 9.97 257 814114 37108 89776968
Poor quality device used 10.05 9.97 4 814367 2289 89811787
Lymph gland infection 10.04 9.97 18 814353 539 89813537
Lung transplant 10.03 9.97 11 814360 3681 89810395
Personality change 10.02 9.97 33 814338 7288 89806788
Metabolic disorder 10.00 9.97 34 814337 7436 89806640
Incorrect dose administered by device 9.99 9.97 23 814348 5714 89808362

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 594.25 10.19 943 238111 41497 42340784
Drug abuse 386.78 10.19 62 238992 104709 42277572
Toxicity to various agents 337.77 10.19 476 238578 228660 42153621
Foetal exposure during pregnancy 315.12 10.19 769 238285 46542 42335739
Completed suicide 288.25 10.19 91 238963 96374 42285907
Psoriatic arthropathy 240.57 10.19 471 238583 24496 42357785
Arthralgia 221.86 10.19 1934 237120 203304 42178977
Drug interaction 186.46 10.19 817 238237 266182 42116099
Sickle cell anaemia with crisis 140.91 10.19 155 238899 4735 42377546
Intentional overdose 140.90 10.19 56 238998 51400 42330881
Psoriasis 130.70 10.19 580 238474 48024 42334257
Dysmorphism 129.87 10.19 124 238930 3192 42379089
Joint swelling 122.87 10.19 726 238328 67296 42314985
Musculoskeletal stiffness 120.56 10.19 641 238413 57124 42325157
Product use in unapproved indication 100.07 10.19 615 238439 183841 42198440
Pain 97.34 10.19 1920 237134 242928 42139353
Acute kidney injury 96.49 10.19 1465 237589 365872 42016409
Arthritis 96.26 10.19 479 238575 41586 42340695
Disease progression 90.41 10.19 456 238598 143200 42239081
Synovitis 89.03 10.19 239 238815 15328 42366953
Rhabdomyolysis 87.55 10.19 192 238862 77827 42304454
Coma 86.15 10.19 104 238950 53450 42328831
Enthesopathy 85.74 10.19 120 238934 4708 42377573
Blood pressure systolic increased 85.44 10.19 347 238707 27621 42354660
Serotonin syndrome 85.38 10.19 20 239034 25825 42356456
Small for dates baby 84.95 10.19 125 238929 5138 42377143
Premature baby 84.50 10.19 304 238750 22849 42359432
Blood pressure fluctuation 83.91 10.19 336 238718 26572 42355709
Death 82.12 10.19 2015 237039 469170 41913111
Febrile neutropenia 77.14 10.19 668 238386 185035 42197246
Hepatic function abnormal 76.90 10.19 106 238948 51461 42330820
Appendicolith 75.35 10.19 205 238849 13251 42369030
Exposure during pregnancy 74.84 10.19 155 238899 8393 42373888
Drug dependence 74.33 10.19 35 239019 29059 42353222
Tenosynovitis 73.61 10.19 110 238944 4585 42377696
Arthropathy 73.45 10.19 345 238709 29252 42353029
Overdose 69.75 10.19 328 238726 104936 42277345
Blood pressure systolic abnormal 68.07 10.19 116 238938 5412 42376869
C-reactive protein abnormal 67.52 10.19 156 238898 9105 42373176
Neonatal respiratory distress syndrome 66.88 10.19 103 238951 4410 42377871
Speech disorder developmental 65.09 10.19 72 238982 2213 42380068
Off label use 64.71 10.19 2926 236128 635409 41746872
Sedation 63.28 10.19 47 239007 30428 42351853
Suicide attempt 60.81 10.19 103 238951 45997 42336284
Blood pressure diastolic abnormal 59.49 10.19 116 238938 6012 42376269
Maternal exposure during pregnancy 59.31 10.19 125 238929 6853 42375428
Foetal anticonvulsant syndrome 58.95 10.19 51 239003 1151 42381130
Drug resistance 57.78 10.19 64 238990 34184 42348097
Stress 57.53 10.19 435 238619 43777 42338504
Tuberculosis 56.69 10.19 154 238900 9945 42372336
Appendicitis 54.64 10.19 245 238809 20368 42361913
Low birth weight baby 54.09 10.19 150 238904 9805 42372476
Hypospadias 53.69 10.19 82 238972 3485 42378796
Angioedema 52.35 10.19 99 238955 42378 42339903
Alanine aminotransferase abnormal 52.20 10.19 97 238957 4847 42377434
Drug ineffective 52.17 10.19 2949 236105 627248 41755033
Hypoglycaemia neonatal 51.58 10.19 62 238992 2088 42380193
Poisoning 51.36 10.19 10 239044 14689 42367592
Cryptorchism 51.18 10.19 60 238994 1967 42380314
Maternal drugs affecting foetus 50.53 10.19 83 238971 3756 42378525
Atrial septal defect 49.81 10.19 126 238928 7793 42374488
Sleep disorder due to a general medical condition 49.42 10.19 18 239036 17435 42364846
Weight decreased 48.63 10.19 1518 237536 206430 42175851
Learning disorder 48.17 10.19 44 239010 1069 42381212
Altered state of consciousness 47.92 10.19 56 238998 29203 42353078
Heart rate decreased 47.84 10.19 360 238694 36172 42346109
Jaundice neonatal 47.70 10.19 60 238994 2119 42380162
Osteoarthritis 47.64 10.19 266 238788 24139 42358142
Haemoglobin decreased 47.64 10.19 1024 238030 131447 42250834
Malignant neoplasm progression 47.18 10.19 385 238669 108015 42274266
Bradycardia 46.29 10.19 285 238769 85199 42297082
Pancytopenia 46.22 10.19 922 238132 116821 42265460
Neuroleptic malignant syndrome 46.04 10.19 32 239022 21440 42360841
Drug reaction with eosinophilia and systemic symptoms 45.99 10.19 105 238949 41970 42340311
Blood pressure diastolic decreased 45.59 10.19 145 238909 10230 42372051
Suicidal ideation 45.09 10.19 130 238924 48031 42334250
Peripheral swelling 45.00 10.19 734 238320 89536 42292745
Autism spectrum disorder 44.00 10.19 68 238986 2920 42379361
Respiratory arrest 43.82 10.19 57 238997 28367 42353914
Drug ineffective for unapproved indication 42.93 10.19 125 238929 46038 42336243
Rheumatoid nodule 42.49 10.19 67 238987 2928 42379353
Sopor 42.08 10.19 11 239043 13191 42369090
Cytomegalovirus infection 41.86 10.19 73 238981 32233 42350048
Cardiac failure 41.85 10.19 390 238664 106466 42275815
Pathogen resistance 41.71 10.19 7 239047 11443 42370838
Renal impairment 41.60 10.19 406 238648 109822 42272459
Joint effusion 41.53 10.19 98 238956 5799 42376482
Syndactyly 40.40 10.19 37 239017 902 42381379
Nasopharyngitis 40.39 10.19 679 238375 83317 42298964
Drug intolerance 39.36 10.19 652 238402 79772 42302509
Maternal exposure during breast feeding 39.22 10.19 46 239008 1509 42380772
Abdominal distension 39.05 10.19 592 238462 71143 42311138
Toxic epidermal necrolysis 38.87 10.19 56 238998 26694 42355587
Palmar-plantar erythrodysaesthesia syndrome 38.68 10.19 35 239019 20547 42361734
Drug use disorder 38.35 10.19 6 239048 10327 42371954
Body temperature decreased 37.97 10.19 171 238883 14242 42368039
Depressed level of consciousness 37.63 10.19 140 238914 47830 42334451
Ventricular septal defect 37.61 10.19 79 238975 4320 42377961
Grip strength decreased 37.39 10.19 70 238984 3518 42378763
Lower respiratory tract infection 37.18 10.19 374 238680 40832 42341449
Tongue disorder 36.34 10.19 88 238966 5295 42376986
Blood pressure diastolic increased 36.28 10.19 98 238956 6307 42375974
Pain in extremity 36.13 10.19 1103 237951 149501 42232780
General physical health deterioration 36.09 10.19 1107 237947 150139 42232142
Pulmonary alveolar haemorrhage 36.07 10.19 19 239035 14797 42367484
Cardiac arrest 35.47 10.19 417 238637 108903 42273378
Inflammation 35.41 10.19 317 238737 33530 42348751
Hand deformity 34.97 10.19 70 238984 3698 42378583
Shock 34.90 10.19 69 238985 29052 42353229
Delirium 34.56 10.19 164 238890 52355 42329926
Developmental delay 34.31 10.19 63 238991 3119 42379162
Bradycardia neonatal 34.20 10.19 40 239014 1308 42380973
Myelosuppression 33.79 10.19 115 238939 40346 42341935
Joint laxity 33.76 10.19 24 239030 402 42381879
Colitis ulcerative 33.74 10.19 257 238797 25918 42356363
Substance abuse 33.44 10.19 5 239049 8900 42373381
Foot deformity 33.31 10.19 82 238972 4986 42377295
Respiratory depression 33.23 10.19 34 239020 18834 42363447
Exposure via breast milk 33.21 10.19 54 239000 2423 42379858
Agitation 32.98 10.19 218 238836 64096 42318185
Neck pain 32.90 10.19 284 238770 29730 42352551
Knee arthroplasty 32.63 10.19 116 238938 8665 42373616
Acute hepatic failure 32.13 10.19 29 239025 17044 42365237
C-reactive protein increased 32.10 10.19 518 238536 63042 42319239
Renal failure 32.08 10.19 590 238464 143136 42239145
Venoocclusive liver disease 32.05 10.19 9 239045 10293 42371988
No adverse event 31.19 10.19 113 238941 38908 42343373
Finger deformity 31.08 10.19 42 239012 1593 42380688
Akathisia 30.94 10.19 10 239044 10441 42371840
Anaphylactic shock 30.59 10.19 53 239001 23464 42358817
Haematochezia 30.55 10.19 479 238575 57957 42324324
Wrong technique in product usage process 30.54 10.19 129 238925 42506 42339775
Cytokine release syndrome 30.51 10.19 137 238917 44390 42337891
Basal cell carcinoma 30.31 10.19 225 238829 22508 42359773
Infusion related reaction 30.13 10.19 494 238560 60312 42321969
Foetal growth restriction 30.09 10.19 81 238973 5202 42377079
Polyarthritis 29.83 10.19 79 238975 5025 42377256
Blood phosphorus increased 29.62 10.19 144 238910 12381 42369900
Drug withdrawal syndrome 29.48 10.19 47 239007 21502 42360779
Abdominal pain 29.42 10.19 1328 237726 189143 42193138
Red blood cell sedimentation rate increased 29.41 10.19 122 238932 9802 42372479
Acute chest syndrome 29.38 10.19 33 239021 1032 42381249
Mucormycosis 29.29 10.19 3 239051 7140 42375141
Tachycardia 29.27 10.19 395 238659 100692 42281589
Cytomegalovirus infection reactivation 29.25 10.19 13 239041 11165 42371116
Respiratory disorder neonatal 29.25 10.19 45 239009 1925 42380356
Therapy partial responder 29.00 10.19 42 239012 19979 42362302
Hyperglycaemia 28.56 10.19 146 238908 45713 42336568
Anal fissure 28.52 10.19 79 238975 5160 42377121
Aspergillus infection 28.51 10.19 28 239026 15809 42366472
Dysgraphia 28.47 10.19 51 239003 2477 42379804
Plagiocephaly 28.43 10.19 25 239029 577 42381704
Abdominal discomfort 28.41 10.19 586 238468 74669 42307612
Caesarean section 28.35 10.19 46 239008 2060 42380221
Toxic optic neuropathy 28.30 10.19 32 239022 1008 42381273
Lactic acidosis 28.24 10.19 144 238910 45117 42337164
Hypoglycaemia 28.17 10.19 208 238846 59646 42322635
Hepatic failure 28.08 10.19 114 238940 37986 42344295
Drug withdrawal syndrome neonatal 28.08 10.19 71 238983 4390 42377891
Hypermobility syndrome 27.73 10.19 20 239034 343 42381938
Cleft lip and palate 27.65 10.19 30 239024 902 42381379
Cardiac murmur 27.48 10.19 143 238911 12632 42369649
Mucocutaneous ulceration 27.30 10.19 23 239031 500 42381781
Forced expiratory volume decreased 27.06 10.19 5 239049 7625 42374656
Blood pressure increased 27.02 10.19 756 238298 101172 42281109
BK virus infection 26.73 10.19 8 239046 8776 42373505
Congenital hand malformation 26.65 10.19 25 239029 629 42381652
Catarrh 26.61 10.19 84 238970 5902 42376379
Post transplant lymphoproliferative disorder 26.52 10.19 9 239045 9111 42373170
Talipes 26.33 10.19 46 239008 2190 42380091
Large for dates baby 25.97 10.19 29 239025 901 42381380
Neurotoxicity 25.86 10.19 59 238995 23592 42358689
Tendonitis 25.77 10.19 117 238937 9777 42372504
Maternal exposure before pregnancy 25.74 10.19 31 239023 1046 42381235
Wound 25.49 10.19 174 238880 16943 42365338
Pruritus 25.38 10.19 836 238218 187935 42194346
Respiratory failure 25.25 10.19 537 238517 127595 42254686
Intentional self-injury 25.00 10.19 29 239025 15173 42367108
Fatigue 24.70 10.19 2797 236257 432844 41949437
Agitation neonatal 24.63 10.19 35 239019 1393 42380888
Suspected suicide 24.42 10.19 3 239051 6196 42376085
Language disorder 24.20 10.19 47 239007 2428 42379853
Acute graft versus host disease 24.07 10.19 8 239046 8207 42374074
Ultrasound antenatal screen 23.83 10.19 22 239032 542 42381739
Musculoskeletal pain 23.83 10.19 289 238765 33051 42349230
Diaphragmatic disorder 23.82 10.19 32 239022 1207 42381074
Ankylosing spondylitis 23.53 10.19 90 238964 6966 42375315
Astigmatism 23.51 10.19 33 239021 1298 42380983
Aggression 23.50 10.19 148 238906 44015 42338266
Withdrawal syndrome 23.43 10.19 29 239025 14746 42367535
Haematocrit decreased 23.41 10.19 299 238755 34609 42347672
Hydrops foetalis 23.20 10.19 27 239027 878 42381403
Burns second degree 23.06 10.19 81 238973 6015 42376266
Anticonvulsant drug level above therapeutic 23.01 10.19 24 239030 689 42381592
Frequent bowel movements 22.65 10.19 201 238853 21206 42361075
Trisomy 18 22.50 10.19 26 239028 839 42381442
Foetal disorder 22.49 10.19 29 239025 1050 42381231
Ventricular tachycardia 22.38 10.19 90 238964 30070 42352211
Neuralgia 22.28 10.19 231 238823 25416 42356865
Blood creatine phosphokinase increased 22.26 10.19 169 238885 48169 42334112
Joint range of motion decreased 21.95 10.19 94 238960 7659 42374622
Systemic lupus erythematosus 21.90 10.19 107 238947 9217 42373064
Low set ears 21.79 10.19 20 239034 489 42381792
Selective eating disorder 21.70 10.19 37 239017 1727 42380554
Pulmonary tuberculosis 21.59 10.19 74 238980 5427 42376854
Arthritis infective 21.45 10.19 61 238993 4045 42378236
Localised infection 21.40 10.19 191 238863 20182 42362099
Arthrodesis 21.39 10.19 21 239033 560 42381721
Motor developmental delay 21.29 10.19 23 239031 688 42381593
Intentional product misuse 21.29 10.19 233 238821 61667 42320614
Knee deformity 21.25 10.19 24 239030 755 42381526
Hypokalaemia 21.21 10.19 279 238775 71442 42310839
Hypoxia 21.18 10.19 270 238784 69516 42312765
Adenovirus infection 21.09 10.19 6 239048 6803 42375478
Dyspraxia 21.06 10.19 19 239035 454 42381827
Hyperbilirubinaemia neonatal 20.87 10.19 25 239029 839 42381442
Hypotonia neonatal 20.78 10.19 33 239021 1451 42380830
Nasal disorder 20.69 10.19 39 239015 1970 42380311
Accidental exposure to product 20.62 10.19 53 239001 20340 42361941
Anal fistula 20.51 10.19 79 238975 6134 42376147
Posterior reversible encephalopathy syndrome 20.50 10.19 25 239029 12796 42369485
Acute graft versus host disease in skin 20.45 10.19 8 239046 7416 42374865
Pulmonary vasculitis 20.40 10.19 5 239049 6261 42376020
Crohn's disease 20.38 10.19 49 239005 2935 42379346
Loss of consciousness 20.31 10.19 380 238674 91974 42290307
Hypertelorism 20.27 10.19 21 239033 598 42381683
Radiation inflammation 20.04 10.19 27 239027 1021 42381260
Cystitis haemorrhagic 20.02 10.19 8 239046 7321 42374960
Vitamin D deficiency 19.95 10.19 94 238960 7979 42374302
Upper respiratory tract infection 19.92 10.19 340 238714 41833 42340448
Skin cancer 19.82 10.19 121 238933 11341 42370940
Blood uric acid increased 19.67 10.19 152 238902 15395 42366886
Gingival pain 19.62 10.19 97 238957 8397 42373884
Temperature regulation disorder 19.39 10.19 28 239026 1131 42381150
Red blood cell count decreased 19.37 10.19 274 238780 32441 42349840
Syringe issue 19.36 10.19 12 239042 8544 42373737
Serum ferritin increased 19.28 10.19 86 238968 7133 42375148
Polyomavirus-associated nephropathy 19.24 10.19 4 239050 5611 42376670
Neck mass 19.16 10.19 36 239018 1814 42380467
Cytomegalovirus viraemia 19.08 10.19 18 239036 10359 42371922
Disseminated intravascular coagulation 19.03 10.19 73 238981 24721 42357560
Cerebral haemorrhage 19.02 10.19 134 238920 38832 42343449
Thymus disorder 18.98 10.19 14 239040 249 42382032
Cardiotoxicity 18.95 10.19 9 239045 7436 42374845
Head discomfort 18.90 10.19 68 238986 5109 42377172
Osteonecrosis of jaw 18.88 10.19 50 239004 18999 42363282
Dyslexia 18.83 10.19 16 239038 352 42381929
Joint stiffness 18.79 10.19 126 238928 12196 42370085
Device leakage 18.73 10.19 18 239036 10267 42372014
Swelling 18.66 10.19 421 238633 54464 42327817
Therapeutic product effect decreased 18.63 10.19 316 238738 38834 42343447
Parosmia 18.60 10.19 89 238965 7602 42374679
Umbilical hernia 18.59 10.19 70 238984 5377 42376904
Drug dose omission by device 18.58 10.19 5 239049 5881 42376400
Mite allergy 18.57 10.19 3 239051 5043 42377238
Ankyloglossia congenital 18.46 10.19 16 239038 362 42381919
Asphyxia 18.40 10.19 12 239042 8314 42373967
Exposure to toxic agent 18.36 10.19 3 239051 5001 42377280
Cleft lip 18.32 10.19 15 239039 313 42381968
Congenital foot malformation 18.31 10.19 17 239037 422 42381859
Electrocardiogram QRS complex prolonged 18.28 10.19 5 239049 5818 42376463
Vitamin B12 deficiency 18.27 10.19 65 238989 4857 42377424
Neoplasm progression 18.24 10.19 92 238962 28908 42353373
Spinal disorder 18.23 10.19 62 238992 4529 42377752
Transient aphasia 18.23 10.19 20 239034 609 42381672
Intellectual disability 18.13 10.19 36 239018 1891 42380390
Urticaria 18.08 10.19 299 238755 73737 42308544
Central nervous system mass 17.94 10.19 23 239031 828 42381453
Blood test abnormal 17.93 10.19 129 238925 12777 42369504
Scoliosis 17.88 10.19 48 239006 3078 42379203
Wall motion score index abnormal 17.86 10.19 23 239031 832 42381449
Lung neoplasm malignant 17.85 10.19 175 238879 18972 42363309
Headache 17.74 10.19 1566 237488 237803 42144478
Anal atresia 17.68 10.19 14 239040 278 42382003
Neurological symptom 17.60 10.19 18 239036 9973 42372308
Melaena 17.59 10.19 136 238918 38610 42343671
Sexual dysfunction 17.54 10.19 8 239046 6767 42375514
Metabolic acidosis 17.51 10.19 196 238858 51662 42330619
Chronic graft versus host disease 17.42 10.19 6 239048 6019 42376262
Pneumonia aspiration 17.42 10.19 188 238866 49890 42332391
Iron deficiency 17.41 10.19 114 238940 10947 42371334
Obsessive-compulsive disorder 17.40 10.19 8 239046 6735 42375546
Cardiac septal defect 17.25 10.19 24 239030 936 42381345
Chronic obstructive pulmonary disease 17.25 10.19 470 238584 62644 42319637
Congenital anomaly 17.24 10.19 31 239023 1510 42380771
Migraine 17.17 10.19 218 238836 25196 42357085
Alcohol poisoning 17.14 10.19 86 238968 7488 42374793
Agranulocytosis 17.12 10.19 101 238953 30511 42351770
Post procedural infection 17.05 10.19 71 238983 5714 42376567
Dermatitis atopic 17.02 10.19 27 239027 12377 42369904
Hypertriglyceridaemia 16.99 10.19 19 239035 10107 42372174
Airway remodelling 16.93 10.19 23 239031 877 42381404
Intervertebral disc degeneration 16.92 10.19 84 238970 7283 42374998
Thrombotic microangiopathy 16.88 10.19 36 239018 14746 42367535
Spina bifida 16.88 10.19 16 239038 408 42381873
Ear disorder 16.85 10.19 36 239018 1992 42380289
Back pain 16.83 10.19 964 238090 140812 42241469
Medical device implantation 16.72 10.19 19 239035 602 42381679
Otitis media 16.67 10.19 52 239002 3631 42378650
Multiple congenital abnormalities 16.57 10.19 18 239036 542 42381739
Transfusion-related circulatory overload 16.55 10.19 21 239033 748 42381533
Red blood cell sedimentation rate 16.50 10.19 25 239029 1055 42381226
Acute respiratory distress syndrome 16.48 10.19 100 238954 30008 42352273
Asthma 16.44 10.19 248 238806 62066 42320215
Colorectal cancer 16.44 10.19 4 239050 5034 42377247
Steroid dependence 16.41 10.19 78 238976 6644 42375637
Cytomegalovirus chorioretinitis 16.40 10.19 3 239051 4608 42377673
Renal aplasia 16.25 10.19 21 239033 762 42381519
Accessory spleen 16.23 10.19 10 239044 130 42382151
Excessive eye blinking 16.18 10.19 19 239035 624 42381657
Hypopnoea 16.11 10.19 87 238967 7795 42374486
Limb reduction defect 16.11 10.19 14 239040 318 42381963
Nephropathy toxic 16.09 10.19 45 239009 16793 42365488
Back disorder 16.08 10.19 84 238970 7430 42374851
Lacrimal disorder 16.03 10.19 14 239040 320 42381961
Fistula discharge 16.02 10.19 25 239029 1083 42381198
Congenital bladder anomaly 15.97 10.19 13 239041 269 42382012
Hypotension 15.84 10.19 1237 237817 256394 42125887
Blood parathyroid hormone decreased 15.82 10.19 31 239023 1612 42380669
Weight decrease neonatal 15.78 10.19 14 239040 327 42381954
Euglycaemic diabetic ketoacidosis 15.75 10.19 6 239048 5654 42376627
Synovial cyst 15.68 10.19 41 239013 2588 42379693
Influenza 15.59 10.19 458 238596 61717 42320564
Ear infection 15.55 10.19 124 238930 12680 42369601
Latent tuberculosis 15.53 10.19 31 239023 1634 42380647
Pectus excavatum 15.51 10.19 12 239042 230 42382051
Atopy 15.51 10.19 23 239031 952 42381329
Rash maculo-papular 15.49 10.19 135 238919 37368 42344913
Pulmonary pain 15.47 10.19 30 239024 1548 42380733
Blood albumin decreased 15.47 10.19 143 238911 15259 42367022
Drug level increased 15.43 10.19 85 238969 26115 42356166
Haemangioma congenital 15.38 10.19 17 239037 522 42381759
Joint ankylosis 15.38 10.19 31 239023 1646 42380635
Squamous cell carcinoma of lung 15.36 10.19 37 239017 2219 42380062
Hypothyroidism 15.33 10.19 111 238943 31973 42350308
Attention deficit hyperactivity disorder 15.11 10.19 45 239009 3063 42379218
Pleuritic pain 15.07 10.19 79 238975 6998 42375283
Disease recurrence 15.01 10.19 101 238953 29577 42352704
Arthritis bacterial 14.99 10.19 69 238985 5799 42376482
Haematotoxicity 14.99 10.19 24 239030 10961 42371320
Proteinuria 14.98 10.19 72 238982 22911 42359370
Granuloma skin 14.92 10.19 25 239029 1150 42381131
Hepatic enzyme increased 14.89 10.19 349 238705 45435 42336846
Tumour lysis syndrome 14.87 10.19 69 238985 22162 42360119
Unresponsive to stimuli 14.83 10.19 109 238945 31294 42350987
Anti-cyclic citrullinated peptide antibody positive 14.82 10.19 33 239021 1879 42380402
Patent ductus arteriosus 14.75 10.19 48 239006 3428 42378853
Hypertransaminasaemia 14.75 10.19 18 239036 9209 42373072
Potentiating drug interaction 14.73 10.19 9 239045 6459 42375822
Sleep disorder therapy 14.71 10.19 77 238977 6817 42375464
Heart rate irregular 14.63 10.19 146 238908 15904 42366377
Exposure via skin contact 14.60 10.19 5 239049 5033 42377248
Rebound effect 14.53 10.19 12 239042 7367 42374914
Psychiatric decompensation 14.48 10.19 3 239051 4219 42378062
Psychotic disorder 14.47 10.19 100 238954 29108 42353173
Cellulitis 14.46 10.19 450 238604 61135 42321146
Pulmonary fibrosis 14.43 10.19 220 238834 26461 42355820
Cholelithiasis 14.42 10.19 197 238857 23149 42359132
Glycosylated haemoglobin increased 14.33 10.19 32 239022 12892 42369389
Malignant melanoma 14.26 10.19 96 238958 9304 42372977
Eosinophilia 14.23 10.19 117 238937 32782 42349499
Gastrointestinal infection 14.17 10.19 75 238979 6668 42375613
Drug therapy 14.13 10.19 72 238982 6308 42375973
Hydrocele 14.11 10.19 39 239015 2544 42379737
Polydactyly 14.03 10.19 25 239029 1209 42381072
Rhinitis 14.01 10.19 115 238939 11862 42370419
Nephrotic syndrome 13.94 10.19 17 239037 8701 42373580
Septic arthritis staphylococcal 13.93 10.19 16 239038 513 42381768
Dystonia 13.91 10.19 32 239022 12758 42369523
Ulcer 13.77 10.19 147 238907 16294 42365987
Abortion spontaneous 13.76 10.19 14 239040 390 42381891
Spondyloarthropathy 13.74 10.19 21 239033 893 42381388
Hepatic steatosis 13.66 10.19 182 238872 21266 42361015
Hyperkalaemia 13.65 10.19 345 238709 80113 42302168
Oesophageal fibrosis 13.65 10.19 10 239044 176 42382105
Neutropenia neonatal 13.64 10.19 21 239033 899 42381382
Carcinoid tumour of the small bowel 13.62 10.19 14 239040 395 42381886
Restlessness 13.59 10.19 102 238952 29147 42353134
Skin injury 13.57 10.19 39 239015 2602 42379679
Endophthalmitis 13.56 10.19 4 239050 4429 42377852
Asymptomatic bacteriuria 13.54 10.19 11 239043 227 42382054
Mania 13.51 10.19 24 239030 10523 42371758
Oxygen saturation decreased 13.47 10.19 466 238588 64221 42318060
Haemolysis 13.41 10.19 96 238958 9493 42372788
Tooth malformation 13.41 10.19 10 239044 181 42382100
Bone cyst 13.37 10.19 29 239025 1622 42380659
Disability assessment scale score increased 13.36 10.19 14 239040 404 42381877
Hernia pain 13.36 10.19 12 239042 285 42381996
Hip arthroplasty 13.27 10.19 62 238992 5243 42377038
Hepatic cyst 13.26 10.19 42 239012 2956 42379325
Bronchopulmonary aspergillosis 13.17 10.19 60 238994 19369 42362912
Interstitial lung disease 13.17 10.19 337 238717 78125 42304156
Anaemia vitamin B12 deficiency 13.12 10.19 16 239038 547 42381734
Ascites 13.01 10.19 413 238641 56265 42326016
Microangiopathy 13.00 10.19 29 239025 1653 42380628
Hepatitis E virus test positive 12.99 10.19 12 239042 296 42381985
Pyrexia 12.98 10.19 1976 237078 392066 41990215
Cerebral infarction 12.96 10.19 112 238942 31057 42351224
Cardiogenic shock 12.95 10.19 276 238778 35364 42346917
Hyperammonaemia 12.94 10.19 15 239039 7851 42374430
Vitamin B complex deficiency 12.91 10.19 15 239039 487 42381794
Red blood cell sedimentation rate abnormal 12.85 10.19 49 239005 3787 42378494
Miosis 12.80 10.19 36 239018 13410 42368871
Foetal heart rate deceleration abnormality 12.76 10.19 16 239038 563 42381718
Anaphylactic reaction 12.73 10.19 166 238888 42577 42339704
Gaze palsy 12.71 10.19 31 239023 1874 42380407
Microphthalmos 12.69 10.19 10 239044 197 42382084
Pancreatic calcification 12.69 10.19 10 239044 197 42382084
Hyperphosphataemia 12.69 10.19 120 238934 12884 42369397
Juvenile idiopathic arthritis 12.63 10.19 38 239016 2601 42379680
Arrhythmia 12.60 10.19 155 238899 40162 42342119
Autoscopy 12.54 10.19 11 239043 253 42382028
Stevens-Johnson syndrome 12.49 10.19 73 238981 22105 42360176
Peritoneal dialysis complication 12.47 10.19 31 239023 1896 42380385
C-reactive protein decreased 12.45 10.19 34 239020 2202 42380079
Hepatitis E antibody positive 12.43 10.19 11 239043 256 42382025
Fine motor skill dysfunction 12.42 10.19 34 239020 2205 42380076
Arnold-Chiari malformation 12.41 10.19 13 239041 375 42381906
Blister infected 12.39 10.19 15 239039 509 42381772
Gangrene neonatal 12.36 10.19 10 239044 205 42382076
Maternal exposure timing unspecified 12.36 10.19 13 239041 377 42381904
Bronchiolitis 12.35 10.19 49 239005 3857 42378424
Cystitis bacterial 12.32 10.19 10 239044 206 42382075
Respiratory rate increased 12.29 10.19 105 238949 10957 42371324
Foetal distress syndrome 12.19 10.19 23 239031 1163 42381118
Bursitis 12.15 10.19 68 238986 6176 42376105
Diverticular perforation 12.06 10.19 47 239007 3669 42378612
Immunosuppression 12.04 10.19 85 238969 8368 42373913
Diverticulum 12.04 10.19 78 238976 7463 42374818
Microcephaly 12.03 10.19 20 239034 914 42381367
Sinusitis 12.03 10.19 349 238705 46943 42335338
Graft versus host disease 12.01 10.19 35 239019 12890 42369391
Haemangioma 11.88 10.19 31 239023 1954 42380327
Myalgia 11.85 10.19 430 238624 95650 42286631
Hypocalcaemia 11.85 10.19 110 238944 30063 42352218
Dysstasia 11.82 10.19 126 238928 13960 42368321
Weight increased 11.82 10.19 729 238325 107254 42275027
Respiratory tract infection viral 11.82 10.19 44 239010 3362 42378919
Injection site haemorrhage 11.80 10.19 109 238945 11627 42370654
Retrognathia 11.78 10.19 11 239043 275 42382006
Transplant rejection 11.77 10.19 38 239016 13550 42368731
Lower respiratory tract congestion 11.72 10.19 27 239027 1573 42380708
Loss of personal independence in daily activities 11.69 10.19 364 238690 49452 42332829
Developmental coordination disorder 11.62 10.19 10 239044 224 42382057
Muscle twitching 11.62 10.19 31 239023 11749 42370532
Extrapyramidal disorder 11.54 10.19 50 239004 16362 42365919
Fistula 11.52 10.19 80 238974 7832 42374449
Skin abrasion 11.52 10.19 82 238972 8093 42374188
Anti-erythropoietin antibody positive 11.52 10.19 19 239035 863 42381418
Hypercapnia 11.48 10.19 8 239046 5353 42376928
Mean cell volume increased 11.45 10.19 48 239006 3875 42378406
Psychomotor retardation 11.44 10.19 52 239002 4347 42377934
Blood homocysteine increased 11.43 10.19 11 239043 286 42381995
Eosinophil count decreased 11.42 10.19 45 239009 3531 42378750
Strabismus 11.42 10.19 34 239020 2314 42379967
Immunodeficiency 11.39 10.19 75 238979 7215 42375066
Glomerular filtration rate decreased 11.38 10.19 50 239004 16301 42365980
Coccydynia 11.37 10.19 16 239038 631 42381650
Dry throat 11.36 10.19 39 239015 2863 42379418
Hand fracture 11.33 10.19 39 239015 2867 42379414
Vascular insufficiency 11.27 10.19 12 239042 353 42381928
Tinea pedis 11.26 10.19 31 239023 2017 42380264
Abdominal adhesions 11.25 10.19 28 239026 1714 42380567
Hospitalisation 11.24 10.19 324 238730 74006 42308275
Educational problem 11.22 10.19 15 239039 563 42381718
Second primary malignancy 11.20 10.19 23 239031 9552 42372729
Mydriasis 11.19 10.19 20 239034 8750 42373531
Cardio-respiratory arrest 11.18 10.19 247 238807 58389 42323892
Blood insulin increased 11.16 10.19 12 239042 357 42381924
Gross motor delay 11.11 10.19 12 239042 359 42381922
Product quality issue 11.09 10.19 57 238997 17825 42364456
Subdural haematoma 11.08 10.19 80 238974 23058 42359223
Facial pain 11.07 10.19 5 239049 4255 42378026
Hyperthermia 11.01 10.19 35 239019 12539 42369742
Contusion 11 10.19 311 238743 41674 42340607
Eosinophilic myocarditis 10.98 10.19 24 239030 1349 42380932
Pleural fibrosis 10.97 10.19 24 239030 1350 42380931
Neutropenia 10.96 10.19 966 238088 198465 42183816
Ligament rupture 10.90 10.19 24 239030 1356 42380925
Oropharyngeal pain 10.89 10.19 314 238740 42196 42340085
Hypermetropia 10.88 10.19 14 239040 506 42381775
Graft versus host disease in skin 10.87 10.19 8 239046 5204 42377077
Palindromic rheumatism 10.86 10.19 9 239045 191 42382090
Ventricular fibrillation 10.85 10.19 233 238821 29890 42352391
Mobility decreased 10.83 10.19 267 238787 35039 42347242
Myoclonus 10.81 10.19 54 239000 17011 42365270
Nocardiosis 10.78 10.19 8 239046 5182 42377099
Infective pulmonary exacerbation of cystic fibrosis 10.74 10.19 17 239037 7801 42374480
Blood folate increased 10.74 10.19 11 239043 309 42381972
Lung cancer metastatic 10.72 10.19 39 239015 2947 42379334
Blood cholesterol increased 10.67 10.19 210 238844 26531 42355750
Nail bed bleeding 10.65 10.19 13 239041 445 42381836
Dissociation 10.61 10.19 4 239050 3794 42378487
Hypermethioninaemia 10.50 10.19 3 239051 3 42382278
Fever neonatal 10.49 10.19 8 239046 150 42382131
Hallucination 10.46 10.19 244 238810 57263 42325018
Osteochondrosis 10.46 10.19 24 239030 1394 42380887
Rotator cuff syndrome 10.44 10.19 68 238986 6518 42375763
Swollen joint count decreased 10.39 10.19 10 239044 260 42382021
Tender joint count decreased 10.39 10.19 10 239044 260 42382021
Protein deficiency 10.33 10.19 10 239044 262 42382019
Fall 10.31 10.19 1483 237571 233037 42149244
Myasthenia gravis 10.30 10.19 137 238917 16000 42366281
Adrenal insufficiency 10.28 10.19 63 238991 18861 42363420
Anal spasm 10.27 10.19 8 239046 155 42382126
Skin graft failure 10.27 10.19 8 239046 155 42382126
Stress ulcer 10.27 10.19 10 239044 264 42382017
Vitamin B6 deficiency 10.26 10.19 11 239043 326 42381955
Diabetes insipidus 10.23 10.19 4 239050 3709 42378572
Pharyngitis 10.20 10.19 85 238969 8805 42373476

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1273.09 9.95 162 832891 242219 109514027
Toxicity to various agents 1224.29 9.95 1091 831962 479464 109276782
Systemic lupus erythematosus 1068.93 9.95 4267 828786 250071 109506175
Arthropathy 1019.25 9.95 4580 828473 282942 109473304
Synovitis 981.22 9.95 4379 828674 269713 109486533
Pemphigus 977.39 9.95 3693 829360 210877 109545369
Hand deformity 955.29 9.95 3712 829341 214794 109541452
Joint swelling 904.62 9.95 6071 826982 436774 109319472
Glossodynia 900.33 9.95 3684 829369 218320 109537926
Drug abuse 852.66 9.95 153 832900 177258 109578988
Anti-cyclic citrullinated peptide antibody positive 777.75 9.95 3070 829983 178914 109577332
Wound 763.73 9.95 3644 829409 230793 109525453
Rheumatoid arthritis 742.29 9.95 4317 828736 295296 109460950
Pericarditis 732.80 9.95 3432 829621 215682 109540564
Maternal exposure during pregnancy 724.54 9.95 3812 829241 251071 109505175
Drug interaction 696.07 9.95 1727 831326 498456 109257790
Abdominal discomfort 664.90 9.95 5159 827894 388699 109367547
Swelling 658.16 9.95 4714 828339 346327 109409919
Duodenal ulcer perforation 652.07 9.95 2861 830192 174839 109581407
Arthralgia 639.72 9.95 8807 824246 770825 108985421
Infusion related reaction 638.55 9.95 4984 828069 376178 109380068
Helicobacter infection 613.32 9.95 2856 830197 179021 109577225
Intentional overdose 597.50 9.95 133 832920 132368 109623878
Alopecia 570.31 9.95 4695 828358 360058 109396188
Psoriatic arthropathy 557.75 9.95 2941 830112 193820 109562426
Therapeutic product effect decreased 543.62 9.95 3424 829629 240892 109515354
Discomfort 495.75 9.95 3038 830015 211669 109544577
Death 491.70 9.95 3165 829888 695704 109060542
Febrile neutropenia 485.23 9.95 1038 832015 315729 109440517
Pain 480.42 9.95 9964 823089 944991 108811255
Rheumatoid factor positive 477.91 9.95 2113 830940 129527 109626719
Musculoskeletal stiffness 468.86 9.95 3660 829393 276162 109480084
Contraindicated product administered 462.10 9.95 3329 829724 244938 109511308
Acute kidney injury 460.09 9.95 2852 830201 632578 109123668
Impaired healing 451.31 9.95 2779 830274 193938 109562308
Hepatic enzyme increased 435.96 9.95 4005 829048 316887 109439359
Folliculitis 405.26 9.95 2401 830652 165252 109590994
Nasopharyngitis 385.47 9.95 4604 828449 389757 109366489
Irritable bowel syndrome 368.54 9.95 2307 830746 161908 109594338
Blister 364.85 9.95 2945 830108 224431 109531815
Exposure during pregnancy 363.92 9.95 2333 830720 165091 109591155
Drug intolerance 359.97 9.95 4659 828394 401853 109354393
Muscle injury 354.19 9.95 2038 831015 138769 109617477
C-reactive protein abnormal 350.65 9.95 1914 831139 127781 109628465
Depressed level of consciousness 337.92 9.95 214 832839 112064 109644182
Disease progression 333.99 9.95 849 832204 243185 109513061
Lower respiratory tract infection 330.93 9.95 3036 830017 240070 109516176
Cardiac arrest 323.97 9.95 618 832435 196135 109560111
Suicide attempt 322.42 9.95 189 832864 103205 109653041
Fibromyalgia 319.74 9.95 2295 830758 168614 109587632
Rheumatic fever 319.36 9.95 1791 831262 120788 109635458
Sleep disorder due to general medical condition, insomnia type 314.35 9.95 1601 831452 104042 109652204
Malignant neoplasm progression 291.19 9.95 544 832509 174023 109582223
Osteoarthritis 279.79 9.95 2341 830712 180282 109575964
Sinusitis 277.63 9.95 3436 829617 293252 109462994
Peripheral swelling 276.88 9.95 4428 828625 399606 109356640
Rhabdomyolysis 275.29 9.95 300 832753 120101 109636145
Overdose 271.07 9.95 880 832173 232914 109523332
Sedation 267.63 9.95 95 832958 69588 109686658
Ill-defined disorder 262.13 9.95 2051 831002 154802 109601444
Neutropenia 256.10 9.95 1710 831343 372910 109383336
Hypersensitivity 250.47 9.95 4356 828697 399642 109356604
Bradycardia 249.47 9.95 496 832557 155021 109601225
Swollen joint count increased 247.57 9.95 1266 831787 82395 109673851
Type 2 diabetes mellitus 246.51 9.95 2224 830829 175008 109581238
Weight increased 245.73 9.95 4484 828569 415160 109341086
Blood cholesterol increased 245.00 9.95 2295 830758 182490 109573756
Stomatitis 240.13 9.95 3100 829953 267142 109489104
Cardiac failure 233.26 9.95 684 832369 186942 109569304
Lactic acidosis 233.11 9.95 213 832840 92598 109663648
Coma 229.48 9.95 332 832721 117537 109638709
Inflammation 226.45 9.95 2339 830714 190899 109565347
Hypotension 214.53 9.95 2721 830332 521128 109235118
Hepatic function abnormal 213.69 9.95 214 832839 89081 109667165
Treatment failure 213.55 9.95 3100 829953 274134 109482112
Contusion 206.88 9.95 2676 830377 230685 109525561
Sickle cell anaemia with crisis 204.78 9.95 303 832750 9242 109747004
Joint range of motion decreased 203.49 9.95 1593 831460 120239 109636007
Renal failure 203.45 9.95 945 832108 225629 109530617
Red blood cell sedimentation rate abnormal 200.06 9.95 517 832536 23992 109732254
Renal impairment 198.40 9.95 739 832314 187706 109568540
Facet joint syndrome 197.97 9.95 1329 831724 95499 109660747
Drug reaction with eosinophilia and systemic symptoms 197.31 9.95 196 832857 81899 109674347
Respiratory failure 195.78 9.95 894 832159 214438 109541808
Respiratory arrest 194.24 9.95 98 832955 58201 109698045
Knee arthroplasty 189.49 9.95 979 832074 63969 109692277
Myelosuppression 186.34 9.95 263 832790 94077 109662169
Pregnancy 184.69 9.95 819 832234 50248 109705998
Serotonin syndrome 184.59 9.95 108 832945 59045 109697201
Angioedema 183.46 9.95 286 832767 98214 109658032
Drug resistance 180.11 9.95 100 832953 56274 109699972
Grip strength decreased 177.68 9.95 1123 831930 79051 109677195
Sopor 176.63 9.95 31 833022 36515 109719731
Arthritis 175.68 9.95 1984 831069 165602 109590644
Agitation 172.47 9.95 371 832682 112680 109643566
Drug ineffective for unapproved indication 170.99 9.95 321 832732 102517 109653729
Hip arthroplasty 170.32 9.95 852 832201 54961 109701285
Intentional product use issue 170.02 9.95 2718 830335 245188 109511058
Hypoglycaemia 169.77 9.95 390 832663 115714 109640532
Blood pressure systolic abnormal 167.80 9.95 489 832564 24361 109731885
Altered state of consciousness 162.45 9.95 118 832935 57508 109698738
Lip dry 161.30 9.95 1298 831755 98785 109657461
Cytokine release syndrome 160.90 9.95 175 832878 70131 109686115
Blood pressure fluctuation 159.62 9.95 1038 832015 73786 109682460
Blood pressure systolic increased 159.52 9.95 1122 831931 81869 109674377
Blood pressure diastolic abnormal 159.21 9.95 492 832561 25323 109730923
Abortion spontaneous 159.10 9.95 594 832459 33688 109722558
Hyperhidrosis 158.93 9.95 797 832256 186501 109569745
Product use issue 153.75 9.95 3246 829807 308449 109447797
Mobility decreased 153.50 9.95 2578 830475 234844 109521402
Live birth 150.10 9.95 967 832086 68517 109687729
Musculoskeletal pain 149.45 9.95 2068 830985 180955 109575291
Cardio-respiratory arrest 149.29 9.95 415 832638 115421 109640825
Neoplasm progression 148.69 9.95 160 832893 64435 109691811
Infection 148.20 9.95 3674 829379 358526 109397720
Cytomegalovirus infection 143.93 9.95 119 832934 54325 109701921
Bursitis 142.98 9.95 1553 831500 128365 109627881
Injury 142.33 9.95 1997 831056 175268 109580978
C-reactive protein increased 141.15 9.95 2367 830686 215552 109540694
Somnolence 140.64 9.95 1496 831557 295953 109460293
Drug dependence 140.25 9.95 103 832950 49917 109706329
Tachycardia 137.11 9.95 1071 831982 225574 109530672
Constipation 136.25 9.95 1886 831167 355900 109400346
Red blood cell sedimentation rate increased 134.15 9.95 1030 832023 77272 109678974
Shock 133.36 9.95 124 832929 53464 109702782
Hepatic failure 132.43 9.95 195 832858 68544 109687702
Metabolic acidosis 131.04 9.95 354 832699 99390 109656856
General physical health deterioration 129.84 9.95 4156 828897 421139 109335107
Hyperglycaemia 128.33 9.95 281 832772 84809 109671437
Syncope 128.22 9.95 945 832108 201591 109554655
Respiratory depression 127.45 9.95 41 833012 31960 109724286
Deep vein thrombosis postoperative 127.37 9.95 824 832229 58467 109697779
Anaphylactic shock 123.93 9.95 123 832930 51423 109704823
Poisoning 123.77 9.95 33 833020 29072 109727174
Thrombocytopenia 122.73 9.95 1868 831185 347017 109409229
Breast cancer stage III 122.05 9.95 1016 832037 78101 109678145
Off label use 120.69 9.95 9700 823353 1490485 108265761
Peripheral venous disease 120.20 9.95 1062 831991 83055 109673191
Electrocardiogram QT prolonged 119.48 9.95 420 832633 108540 109647706
Hypoxia 119.30 9.95 535 832518 128980 109627266
Wound infection 118.86 9.95 1180 831873 95285 109660961
Hyperkalaemia 118.56 9.95 572 832481 135224 109621022
Liver injury 118.53 9.95 1689 831364 148724 109607522
Dry mouth 118.41 9.95 2141 830912 197807 109558439
Cognitive disorder 117.68 9.95 307 832746 87204 109669042
Intentional self-injury 117.26 9.95 68 832985 37361 109718885
Gastrointestinal disorder 116.78 9.95 2512 830541 239440 109516806
Joint effusion 116.69 9.95 385 832668 20520 109735726
Obesity 116.54 9.95 1337 831716 112014 109644232
Ventricular tachycardia 114.96 9.95 124 832929 49885 109706361
Drug use disorder 114.64 9.95 5 833048 18069 109738177
Sciatica 113.72 9.95 1130 831923 91269 109664977
Multiple organ dysfunction syndrome 110.96 9.95 678 832375 151032 109605214
Disseminated intravascular coagulation 110.68 9.95 89 832964 41197 109715049
Sedation complication 107.30 9.95 12 833041 19843 109736403
Intentional product misuse 106.29 9.95 577 832476 132327 109623919
Pain in extremity 106.05 9.95 4584 828469 482534 109273712
Product use in unapproved indication 104.72 9.95 2567 830486 444810 109311436
Condition aggravated 104.27 9.95 6640 826413 728196 109028050
Autoimmune disorder 103.73 9.95 846 832207 64637 109691609
Hyponatraemia 102.71 9.95 1095 831958 216558 109539688
Disability assessment scale score increased 101.03 9.95 142 832911 4128 109752118
Suspected suicide 100.57 9.95 3 833050 15196 109741050
Suicidal ideation 100.39 9.95 366 832687 93571 109662675
Cerebral haemorrhage 99.25 9.95 213 832840 64755 109691491
Foot deformity 97.03 9.95 662 832391 47818 109708428
Joint stiffness 95.57 9.95 848 832205 66395 109689851
Fatigue 94.56 9.95 10499 822554 1205459 108550787
Road traffic accident 94.01 9.95 1229 831824 106169 109650077
Bone erosion 93.88 9.95 635 832418 45736 109710510
Neuroleptic malignant syndrome 93.09 9.95 72 832981 33987 109722259
Dehydration 93.06 9.95 1512 831541 277999 109478247
Blood creatine phosphokinase increased 91.80 9.95 265 832788 72812 109683434
Blood pressure diastolic decreased 90.56 9.95 520 832533 35365 109720881
Restlessness 90.56 9.95 179 832874 56080 109700166
Mydriasis 88.93 9.95 28 833025 22129 109734117
Hepatocellular injury 88.73 9.95 153 832900 50489 109705757
Cardiac failure congestive 88.31 9.95 720 832333 150280 109605966
No adverse event 88.27 9.95 274 832779 73565 109682681
Myalgia 86.84 9.95 1166 831887 221215 109535031
Orthostatic hypotension 86.35 9.95 236 832817 66013 109690233
Hypoaesthesia 86.24 9.95 3033 830020 311190 109445056
Neutrophil count decreased 86.10 9.95 545 832508 120396 109635850
Neurotoxicity 86.02 9.95 115 832938 42092 109714154
Atrial fibrillation 85.76 9.95 1215 831838 228427 109527819
Gait inability 85.60 9.95 1474 831579 134902 109621344
Myocardial infarction 85.21 9.95 980 832073 191103 109565143
Encephalopathy 85.18 9.95 318 832735 80737 109675509
Chest discomfort 85.12 9.95 867 832186 172981 109583265
Psoriasis 84.26 9.95 1503 831550 138490 109617756
Aspergillus infection 83.93 9.95 44 833009 25572 109730674
Enthesopathy 83.72 9.95 245 832808 12233 109744013
Sleep disorder 83.56 9.95 2023 831030 196621 109559625
Heart rate decreased 82.77 9.95 971 832082 81785 109674461
Leukopenia 82.71 9.95 719 832334 148072 109608174
Venoocclusive liver disease 82.67 9.95 9 833044 15198 109741048
Drug withdrawal syndrome 82.42 9.95 99 832954 37955 109718291
Tremor 82.02 9.95 1052 832001 201180 109555066
Thrombotic microangiopathy 81.75 9.95 60 832993 29089 109727157
Wrong technique in product usage process 81.53 9.95 359 832694 86989 109669257
Rash 81.52 9.95 7211 825842 813753 108942493
Dry skin 81.40 9.95 476 832577 107177 109649069
Adverse event 81.04 9.95 1210 831843 107599 109648647
Post transplant lymphoproliferative disorder 80.55 9.95 11 833042 15602 109740644
Pulmonary fibrosis 80.04 9.95 1145 831908 100897 109655349
Sepsis 79.94 9.95 1866 831187 325480 109430766
Cholestasis 79.56 9.95 236 832817 64282 109691964
Injection site reaction 78.26 9.95 1020 832033 88050 109668196
Dislocation of vertebra 78.19 9.95 581 832472 43140 109713106
Pulmonary alveolar haemorrhage 78.18 9.95 27 833026 20123 109736123
Accidental exposure to product 78.03 9.95 162 832891 49846 109706400
Acute hepatic failure 77.80 9.95 96 832957 36372 109719874
Polyarthritis 76.97 9.95 315 832738 18648 109737598
Temperature regulation disorder 76.82 9.95 5 833048 12821 109743425
Seizure 76.79 9.95 1187 831866 219998 109536248
Hypothermia 76.58 9.95 52 833001 26250 109729996
Osteoporosis 76.56 9.95 998 832055 86154 109670092
Palmar-plantar erythrodysaesthesia syndrome 76.49 9.95 119 832934 40906 109715340
Anaphylactic reaction 76.35 9.95 525 832528 113775 109642471
Miosis 76.21 9.95 35 833018 21948 109734298
Lower limb fracture 76.21 9.95 886 832167 74462 109681784
Hallucination 75.90 9.95 450 832603 100982 109655264
Posterior reversible encephalopathy syndrome 75.59 9.95 86 832967 33775 109722471
Adjustment disorder with depressed mood 75.01 9.95 577 832476 43306 109712940
Therapy partial responder 74.49 9.95 102 832951 36959 109719287
Withdrawal syndrome 74.16 9.95 76 832977 31304 109724942
Hypercholesterolaemia 73.95 9.95 1026 832027 89811 109666435
Cytomegalovirus infection reactivation 73.88 9.95 23 833030 18310 109737936
Juvenile idiopathic arthritis 73.83 9.95 149 832904 5858 109750388
Forced expiratory volume decreased 73.70 9.95 7 833046 13169 109743077
Joint destruction 73.56 9.95 215 832838 10728 109745518
Pathogen resistance 73.35 9.95 21 833032 17651 109738595
Cerebral infarction 72.68 9.95 178 832875 51660 109704586
Skin exfoliation 72.61 9.95 376 832677 87275 109668971
Torsade de pointes 72.32 9.95 40 833013 22560 109733686
Aggression 71.99 9.95 218 832835 58992 109697254
Akathisia 71.65 9.95 20 833033 17093 109739153
Rheumatoid nodule 71.49 9.95 323 832730 19973 109736273
Night sweats 71.49 9.95 1412 831641 132571 109623675
Hypokalaemia 71.45 9.95 956 832097 181492 109574754
Myoclonus 71.31 9.95 86 832967 32912 109723334
Loss of consciousness 70.37 9.95 1047 832006 195259 109560987
Disease recurrence 70.24 9.95 229 832824 60555 109695691
Disorientation 69.94 9.95 284 832769 70387 109685859
Bronchopulmonary aspergillosis 69.81 9.95 73 832980 29790 109726456
Vision blurred 69.28 9.95 629 832424 128393 109627853
Unresponsive to stimuli 69.18 9.95 247 832806 63543 109692703
Exposure to toxic agent 68.91 9.95 8 833045 12850 109743396
Asphyxia 68.82 9.95 12 833041 14203 109742043
Disturbance in attention 68.61 9.95 238 832815 61757 109694489
Drug level increased 68.37 9.95 162 832891 47557 109708689
BK virus infection 68.17 9.95 9 833044 13097 109743149
Interstitial lung disease 68.15 9.95 695 832358 138639 109617607
Anaemia 67.83 9.95 3398 829655 543688 109212558
Blood glucose increased 67.26 9.95 655 832398 131841 109624405
Nausea 67.22 9.95 8218 824835 1227472 108528774
Dysphagia 67.21 9.95 786 832267 152814 109603432
Ejection fraction decreased 66.72 9.95 129 832924 40751 109715495
Acute graft versus host disease 66.64 9.95 9 833044 12872 109743374
Proteinuria 66.43 9.95 125 832928 39893 109716353
Substance abuse 66.19 9.95 8 833045 12455 109743791
C-reactive protein 66.04 9.95 423 832630 29908 109726338
Extrapyramidal disorder 65.88 9.95 72 832981 28795 109727451
Melaena 65.75 9.95 280 832773 68477 109687769
Blepharospasm 65.17 9.95 666 832387 54185 109702061
Tuberculosis 64.97 9.95 286 832767 17488 109738758
Tenosynovitis 64.92 9.95 269 832784 16014 109740232
Caesarean section 64.60 9.95 240 832813 13577 109742669
Acute respiratory distress syndrome 64.58 9.95 196 832857 53002 109703244
Blood creatinine increased 64.32 9.95 979 832074 181910 109574336
Creatinine renal clearance decreased 63.69 9.95 43 833010 21772 109734474
Dysarthria 63.57 9.95 372 832681 83749 109672497
Balance disorder 62.69 9.95 568 832485 115992 109640254
Body temperature decreased 61.67 9.95 483 832570 36452 109719794
Haematotoxicity 60.96 9.95 42 833011 21040 109735206
Diabetic ketoacidosis 60.88 9.95 142 832911 41916 109714330
Platelet count decreased 60.68 9.95 1298 831755 229145 109527101
Exostosis 60.46 9.95 570 832483 45386 109710860
Respiratory distress 60.16 9.95 290 832763 68584 109687662
Blood pressure diastolic increased 60.15 9.95 291 832762 18516 109737730
Personality disorder 59.66 9.95 12 833041 12825 109743421
Pulmonary oedema 59.29 9.95 479 832574 100180 109656066
Laryngitis 58.80 9.95 532 832521 41879 109714367
Joint laxity 58.77 9.95 83 832970 2424 109753822
Eosinophilia 58.49 9.95 231 832822 57705 109698541
Arrhythmia 58.45 9.95 297 832756 69278 109686968
Aphasia 58.44 9.95 237 832816 58760 109697486
Onychomycosis 57.92 9.95 492 832561 38039 109718207
Second primary malignancy 57.78 9.95 32 833021 18036 109738210
Tumour lysis syndrome 57.75 9.95 89 832964 30712 109725534
Neurologic neglect syndrome 57.59 9.95 3 833050 9295 109746951
Hemiplegia 57.53 9.95 52 833001 22730 109733516
Dyspnoea 57.08 9.95 7386 825667 1099486 108656760
Onychomadesis 56.93 9.95 560 832493 45103 109711143
Retinitis 56.90 9.95 428 832625 31899 109724347
Graft versus host disease 56.35 9.95 36 833017 18770 109737476
Abnormal behaviour 55.56 9.95 133 832920 38906 109717340
Gamma-glutamyltransferase increased 55.40 9.95 255 832798 61054 109695192
Lupus-like syndrome 55.19 9.95 509 832544 40283 109715963
Speech disorder 55.09 9.95 257 832796 61312 109694934
Tachypnoea 54.66 9.95 136 832917 39259 109716987
Neuropathy peripheral 54.40 9.95 986 832067 178291 109577955
Haemoptysis 53.67 9.95 316 832737 71038 109685208
Mucormycosis 53.64 9.95 8 833045 10620 109745626
COVID-19 53.55 9.95 1420 831633 243640 109512606
Gestational diabetes 53.38 9.95 149 832904 7240 109749006
Coagulopathy 53.12 9.95 146 832907 40765 109715481
Transplant rejection 53.11 9.95 64 832989 24503 109731743
Localised infection 52.73 9.95 526 832527 42522 109713724
Angina pectoris 52.29 9.95 266 832787 62029 109694217
Graft versus host disease in gastrointestinal tract 52.25 9.95 4 833049 8964 109747282
Ear infection 52.05 9.95 711 832342 62021 109694225
Osteonecrosis of jaw 52.02 9.95 186 832867 47831 109708415
Pancreatitis acute 51.95 9.95 255 832798 60019 109696227
Stevens-Johnson syndrome 51.93 9.95 180 832873 46721 109709525
Clostridium difficile colitis 51.93 9.95 163 832890 43615 109712631
Basal cell carcinoma 50.64 9.95 543 832510 44727 109711519
Dermatitis atopic 50.63 9.95 71 832982 25470 109730776
Cytomegalovirus viraemia 50.55 9.95 36 833017 17728 109738518
Drug dose omission by device 50.49 9.95 23 833030 14493 109741753
Septic shock 50.47 9.95 858 832195 156670 109599576
Exposure via skin contact 50.35 9.95 18 833035 13129 109743117
X-ray abnormal 50.25 9.95 473 832580 37644 109718602
Lupus vulgaris 50.06 9.95 431 832622 33452 109722794
Acute graft versus host disease in skin 50.00 9.95 10 833043 10730 109745516
Device difficult to use 49.83 9.95 41 833012 18764 109737482
Bronchospasm 49.72 9.95 95 832958 30144 109726102
Anti-cyclic citrullinated peptide antibody 49.53 9.95 288 832765 19676 109736570
Finger deformity 49.45 9.95 422 832631 32670 109723576
Haemophagocytic lymphohistiocytosis 49.43 9.95 102 832951 31457 109724789
Carotid artery thrombosis 49.23 9.95 7 833046 9631 109746615
Unintentional medical device removal 49.23 9.95 5 833048 8918 109747328
Rebound effect 49.15 9.95 25 833028 14781 109741465
Lung disorder 49.13 9.95 1737 831316 178310 109577936
Hypothyroidism 49.10 9.95 334 832719 72565 109683681
Maternal exposure before pregnancy 49.08 9.95 143 832910 7122 109749124
White blood cell count decreased 48.87 9.95 1334 831719 228056 109528190
Loss of personal independence in daily activities 48.31 9.95 1476 831577 148544 109607702
Brain oedema 48.30 9.95 101 832952 30997 109725249
Palpitations 48.19 9.95 876 832177 158336 109597910
Acute respiratory failure 48.15 9.95 350 832703 74910 109681336
Chronic kidney disease 47.75 9.95 357 832696 75934 109680312
Psychotic disorder 47.75 9.95 209 832844 50728 109705518
Adenovirus infection 47.64 9.95 12 833041 10982 109745264
Diarrhoea 47.39 9.95 7702 825351 1131803 108624443
Mental status changes 47.27 9.95 357 832696 75765 109680481
Gastrointestinal haemorrhage 47.23 9.95 920 832133 164598 109591648
Dystonia 47.02 9.95 76 832977 25729 109730517
Metastases to liver 46.91 9.95 125 832928 35261 109720985
Polyomavirus-associated nephropathy 46.83 9.95 4 833049 8197 109748049
Cytopenia 46.61 9.95 98 832955 30018 109726228
Face oedema 46.08 9.95 116 832937 33353 109722893
Appendicolith 45.18 9.95 220 832833 14035 109742211
Psychomotor hyperactivity 44.72 9.95 52 833001 20225 109736021
Inappropriate antidiuretic hormone secretion 44.56 9.95 120 832933 33731 109722515
Metastases to bone 44.55 9.95 107 832946 31265 109724981
Agranulocytosis 44.11 9.95 278 832775 61482 109694764
Oedema 44.05 9.95 1969 831084 208007 109548239
Acute chest syndrome 44.03 9.95 66 832987 2037 109754209
Blood pressure decreased 43.99 9.95 606 832447 114485 109641761
Hemiparesis 43.71 9.95 176 832877 43727 109712519
Hepatic cirrhosis 43.54 9.95 734 832319 66892 109689354
Cerebrovascular accident 43.49 9.95 1036 832017 180248 109575998
Coordination abnormal 43.48 9.95 77 832976 25151 109731095
Nail disorder 43.41 9.95 645 832408 57290 109698956
Rash maculo-papular 43.34 9.95 354 832699 73868 109682378
Bradyphrenia 43.33 9.95 17 833036 11711 109744535
Cardiotoxicity 43.27 9.95 38 833015 16843 109739403
Hallucination, visual 43.18 9.95 153 832900 39452 109716794
Acute generalised exanthematous pustulosis 43.16 9.95 60 832993 21604 109734642
Joint dislocation 42.96 9.95 420 832633 33770 109722476
Obstructive airways disorder 42.87 9.95 190 832863 45959 109710287
Ischaemic stroke 42.63 9.95 163 832890 41100 109715146
Haemorrhage intracranial 42.58 9.95 97 832956 28872 109727374
Acute myocardial infarction 42.58 9.95 414 832639 83363 109672883
Red blood cell sedimentation rate 42.56 9.95 110 832943 5104 109751142
Hyperthermia 42.30 9.95 59 832994 21213 109735033
Pneumonia aspiration 41.89 9.95 400 832653 80833 109675413
Muscle twitching 41.80 9.95 103 832950 29832 109726414
Chronic graft versus host disease 41.61 9.95 10 833043 9447 109746799
Wheezing 41.47 9.95 2335 830718 252895 109503351
Blood bilirubin increased 41.38 9.95 369 832684 75603 109680643
Irritability 41.35 9.95 202 832851 47607 109708639
Urinary retention 41.31 9.95 331 832722 69352 109686894
Flushing 41.28 9.95 548 832505 104188 109652058
Latent tuberculosis 41.18 9.95 92 832961 3885 109752361
Mania 41.03 9.95 58 832995 20738 109735508
Premature labour 40.96 9.95 157 832896 9015 109747231
Maternal exposure timing unspecified 40.90 9.95 285 832768 20728 109735518
Haemorrhage 40.69 9.95 562 832491 106130 109650116
Blood alkaline phosphatase increased 40.65 9.95 340 832713 70595 109685651
Erythema multiforme 40.48 9.95 60 832993 21037 109735209
Electrocardiogram QRS complex prolonged 40.30 9.95 24 833029 12997 109743249
Bacteraemia 40.30 9.95 173 832880 42217 109714029
Hypomagnesaemia 39.96 9.95 278 832775 60092 109696154
Tongue disorder 39.96 9.95 213 832840 14085 109742161
Injection site erythema 39.85 9.95 960 832093 93216 109663030
Leukocytosis 39.63 9.95 240 832813 53588 109702658
Pleural effusion 39.54 9.95 1027 832026 176682 109579564
Haematoma 39.34 9.95 268 832785 58208 109698038
Epstein-Barr virus infection 39.27 9.95 50 833003 18688 109737558
Back injury 39.23 9.95 537 832516 46862 109709384
Migraine 39.21 9.95 1624 831429 170028 109586218
Tendonitis 39.18 9.95 333 832720 25750 109730496
Schizophrenia 39.10 9.95 65 832988 21761 109734485
Acute myeloid leukaemia 39.08 9.95 151 832902 37959 109718287
Wheelchair user 39.02 9.95 139 832914 7703 109748543
Pseudomonas infection 38.76 9.95 96 832957 27757 109728489
Prescribed overdose 38.65 9.95 898 832155 86683 109669563
Alanine aminotransferase abnormal 38.64 9.95 156 832897 9178 109747068
Skin haemorrhage 38.25 9.95 81 832972 24746 109731500
Metastases to central nervous system 38.11 9.95 71 832982 22746 109733500
Conjunctivitis allergic 37.94 9.95 4 833049 6927 109749319
Graft versus host disease in skin 37.77 9.95 8 833045 8246 109748000
Myocarditis 37.73 9.95 109 832944 29946 109726300
Fluid retention 37.69 9.95 492 832561 93815 109662431
Cardiomyopathy 37.57 9.95 128 832925 33397 109722849
Klebsiella infection 37.34 9.95 58 832995 19951 109736295
Eating disorder 37.24 9.95 114 832939 30744 109725502
Hyperbilirubinaemia 37.23 9.95 113 832940 30558 109725688
Subdural haematoma 37.02 9.95 145 832908 36309 109719937
Potentiating drug interaction 36.69 9.95 21 833032 11622 109744624
Coronary artery disease 36.55 9.95 354 832699 71336 109684910
Stress cardiomyopathy 36.54 9.95 39 833014 15767 109740479
Asthma-chronic obstructive pulmonary disease overlap syndrome 36.49 9.95 3 833050 6341 109749905
Motor dysfunction 36.46 9.95 81 832972 24325 109731921
Depressed mood 36.44 9.95 288 832765 60521 109695725
Neck deformity 36.40 9.95 57 832996 1829 109754417
Neck pain 36.38 9.95 1199 831854 121931 109634315
Nodule 36.31 9.95 391 832662 32240 109724006
Shock haemorrhagic 36.31 9.95 96 832957 27151 109729095
Parkinsonism 36.22 9.95 70 832983 22117 109734129
Premature rupture of membranes 35.99 9.95 96 832957 4541 109751705
Drug tolerance decreased 35.93 9.95 341 832712 27199 109729047
Cystitis haemorrhagic 35.73 9.95 24 833029 12185 109744061
Neck mass 35.60 9.95 98 832955 4723 109751523
Fear 35.45 9.95 76 832977 23117 109733129
Femur fracture 35.27 9.95 500 832553 43969 109712277
Emotional distress 35.13 9.95 196 832857 44651 109711595
Spinal stenosis 35.08 9.95 255 832798 18801 109737445
Glomerular filtration rate decreased 34.92 9.95 107 832946 28849 109727397
Labelled drug-drug interaction medication error 34.83 9.95 109 832944 29193 109727053
Nocardiosis 34.79 9.95 7 833046 7479 109748767
Anuria 34.58 9.95 83 832970 24258 109731988
Dyskinesia 34.50 9.95 236 832817 51210 109705036
Cyanosis 34.39 9.95 112 832941 29629 109726617
Respiratory acidosis 34.39 9.95 32 833021 13794 109742452
Injection site pruritus 34.34 9.95 560 832493 50698 109705548
Cardiac failure acute 34.29 9.95 82 832971 23996 109732250
Food allergy 34.28 9.95 61 832992 19887 109736359
Blood calcium decreased 34.25 9.95 146 832907 35699 109720547
Smear cervix abnormal 34.20 9.95 68 832985 2644 109753602
Febrile bone marrow aplasia 34.17 9.95 49 833004 17416 109738830
Muscle rigidity 34.09 9.95 82 832971 23949 109732297
Dust allergy 34.07 9.95 3 833050 5998 109750248
Premature delivery 34.06 9.95 367 832686 30265 109725981
Generalised oedema 33.89 9.95 118 832935 30586 109725660
Euglycaemic diabetic ketoacidosis 33.81 9.95 23 833030 11600 109744646
Product prescribing error 33.67 9.95 237 832816 51094 109705152
Immune effector cell-associated neurotoxicity syndrome 33.59 9.95 37 833016 14745 109741501
Acidosis 33.48 9.95 75 832978 22456 109733790
Prescribed underdose 33.47 9.95 683 832370 64491 109691755
Device leakage 33.44 9.95 43 833010 16005 109740241
Distributive shock 33.39 9.95 3 833050 5901 109750345
Fracture 33.38 9.95 309 832744 24479 109731767
Haemodynamic instability 33.35 9.95 77 832976 22811 109733435
Metastases to lung 33.27 9.95 78 832975 22985 109733261
Adjustment disorder 33.27 9.95 20 833033 10775 109745471
Device expulsion 33.24 9.95 120 832933 30771 109725475
Pemphigoid 33.20 9.95 61 832992 19646 109736600
Disability 33.10 9.95 361 832692 29862 109726384
Diabetes insipidus 33.03 9.95 5 833048 6565 109749681
Oliguria 33.02 9.95 56 832997 18601 109737645
Feeling abnormal 32.99 9.95 1073 831980 179638 109576608
Multiple sclerosis relapse 32.94 9.95 232 832821 50008 109706238
Hepatitis B reactivation 32.76 9.95 8 833045 7476 109748770
Lip swelling 32.71 9.95 235 832818 50432 109705814
Synovial cyst 32.44 9.95 171 832882 11259 109744987
Colorectal cancer 32.40 9.95 14 833039 9100 109747146
Arthritis infective 32.37 9.95 160 832893 10269 109745977
Device use error 32.25 9.95 14 833039 9075 109747171
Pre-eclampsia 32.24 9.95 140 832913 8510 109747736
Sexual dysfunction 32.12 9.95 12 833041 8518 109747728
Nephropathy toxic 32.11 9.95 103 832950 27375 109728871
Ankylosing spondylitis 31.72 9.95 214 832839 15398 109740848
Glycosylated haemoglobin increased 31.64 9.95 83 832970 23536 109732710
Enterocolitis 31.62 9.95 59 832994 18890 109737356
Hyperammonaemia 31.61 9.95 34 833019 13698 109742548
Tenderness 31.50 9.95 350 832703 29087 109727159
Ileus 31.35 9.95 122 832931 30607 109725639
Immune reconstitution inflammatory syndrome 31.28 9.95 46 833007 16180 109740066
Rash erythematous 31.22 9.95 431 832622 81401 109674845
Gastroenteritis viral 31.04 9.95 366 832687 30860 109725386
Pulmonary embolism 30.77 9.95 1311 831742 213163 109543083
Pulmonary vasculitis 30.77 9.95 6 833047 6554 109749692
Dissociation 30.66 9.95 18 833035 9824 109746422
Rhinitis allergic 30.62 9.95 55 832998 17867 109738379
Sensory loss 30.61 9.95 73 832980 21384 109734862
Jaundice cholestatic 30.59 9.95 39 833014 14569 109741677
Generalised tonic-clonic seizure 30.48 9.95 264 832789 54416 109701830
Circulatory collapse 30.45 9.95 194 832859 42799 109713447
Candida infection 30.36 9.95 224 832829 47785 109708461
Infective pulmonary exacerbation of cystic fibrosis 30.35 9.95 40 833013 14731 109741515
Hyperuricaemia 30.22 9.95 39 833014 14492 109741754
Toxic skin eruption 30.19 9.95 106 832947 27409 109728837
Mite allergy 30.15 9.95 4 833049 5799 109750447
Hallucination, auditory 30.12 9.95 100 832953 26297 109729949
Seronegative arthritis 30.07 9.95 186 832867 12991 109743255
Blood parathyroid hormone decreased 30.02 9.95 185 832868 12904 109743342
Rotator cuff repair 30.01 9.95 58 832995 2208 109754038
Cardiac failure chronic 29.84 9.95 36 833017 13775 109742471
Multiple fractures 29.80 9.95 140 832913 8800 109747446
Tardive dyskinesia 29.76 9.95 35 833018 13544 109742702
Acute coronary syndrome 29.62 9.95 83 832970 23029 109733217
Limb deformity 29.53 9.95 78 832975 3668 109752578
Scleritis 29.52 9.95 99 832954 5321 109750925
Sinus bradycardia 29.47 9.95 118 832935 29365 109726881
Anxiety 29.39 9.95 2219 830834 342859 109413387
Pulmonary arterial hypertension 29.10 9.95 136 832917 32432 109723814
Mental disorder 29.06 9.95 172 832881 38619 109717627
Sleep terror 29.06 9.95 7 833046 6603 109749643
Pulmonary congestion 29.06 9.95 127 832926 30839 109725407
Pulseless electrical activity 29.01 9.95 51 833002 16706 109739540
Mouth ulceration 29.01 9.95 517 832536 47621 109708625
Multiple drug therapy 28.98 9.95 12 833041 8002 109748244
Liver function test increased 28.72 9.95 872 832181 87676 109668570
Cytomegalovirus chorioretinitis 28.62 9.95 9 833044 7119 109749127
Dermatitis acneiform 28.60 9.95 32 833021 12663 109743583
Chills 28.59 9.95 1159 831894 189421 109566825
Pulmonary haemorrhage 28.57 9.95 50 833003 16406 109739840
Pyrexia 28.54 9.95 6157 826896 892108 108864138
Pruritus genital 28.49 9.95 7 833046 6515 109749731
Skin toxicity 28.46 9.95 28 833025 11755 109744491
Endophthalmitis 28.43 9.95 13 833040 8174 109748072
Subarachnoid haemorrhage 28.37 9.95 121 832932 29581 109726665
Hypogammaglobulinaemia 28.09 9.95 69 832984 20007 109736239
Vasoplegia syndrome 27.67 9.95 4 833049 5435 109750811
Hypernatraemia 27.62 9.95 58 832995 17775 109738471
Granuloma skin 27.49 9.95 162 832891 11121 109745125
Bladder cancer 27.42 9.95 71 832982 20221 109736025
Lethargy 27.33 9.95 518 832535 93058 109663188
Antinuclear antibody positive 27.29 9.95 139 832914 9029 109747217
Gangrene 27.16 9.95 51 833002 16290 109739956
Device related infection 27.14 9.95 180 832873 39339 109716907
Malignant mediastinal neoplasm 27.09 9.95 42 833011 1336 109754910
Bone pain 27.07 9.95 337 832716 64796 109691450
International normalised ratio increased 27.02 9.95 475 832578 86297 109669949
Sleep disorder due to a general medical condition 26.70 9.95 257 832796 51855 109704391
Eye pruritus 26.35 9.95 142 832911 32633 109723613
Immune-mediated myositis 26.33 9.95 7 833046 6179 109750067
Diplopia 26.24 9.95 196 832857 41698 109714548
Colitis ulcerative 26.21 9.95 766 832287 76597 109679649
Synovial disorder 26.17 9.95 65 832988 2942 109753304
Lymphocyte count decreased 26.17 9.95 290 832763 56953 109699293
Polyneuropathy 26.13 9.95 138 832915 31874 109724372
Pulmonary tuberculosis 26.12 9.95 137 832916 9002 109747244
Toxic epidermal necrolysis 26.09 9.95 287 832766 56440 109699806
Bone disorder 25.98 9.95 259 832794 20933 109735313
Erythema 25.96 9.95 1867 831186 289580 109466666
Blood lactic acid increased 25.75 9.95 50 833003 15771 109740475
Delusion 25.74 9.95 92 832961 23663 109732583
Pneumonia bacterial 25.69 9.95 106 832947 26155 109730091
Renal tubular necrosis 25.65 9.95 130 832923 30345 109725901
Diabetes mellitus inadequate control 25.64 9.95 126 832927 29649 109726597
Atrial tachycardia 25.60 9.95 19 833034 9159 109747087
Drug effective for unapproved indication 25.56 9.95 42 833011 14125 109742121
Hypercapnia 25.28 9.95 28 833025 11131 109745115
Epistaxis 25.27 9.95 768 832285 129604 109626642
Skin ulcer 25.20 9.95 643 832410 63002 109693244
Drug tolerance 25.05 9.95 212 832841 16373 109739873
Product preparation error 24.97 9.95 27 833026 10852 109745394
Nasal polyps 24.88 9.95 38 833015 13162 109743084
Hyperpyrexia 24.80 9.95 15 833038 8054 109748192
Paralysis 24.79 9.95 50 833003 15550 109740696
Accidental death 24.76 9.95 4 833049 5005 109751241
Paranoia 24.68 9.95 86 832967 22288 109733958
Rheumatoid lung 24.68 9.95 80 832973 4224 109752022
Normal newborn 24.66 9.95 263 832790 21633 109734613
Pneumatosis intestinalis 24.65 9.95 17 833036 8512 109747734
Hyperlactacidaemia 24.64 9.95 16 833037 8270 109747976
Synovial fluid analysis 24.45 9.95 59 832994 2622 109753624
Virologic failure 24.37 9.95 4 833049 4948 109751298
Atrioventricular block complete 24.37 9.95 74 832979 20008 109736238
Ketoacidosis 24.33 9.95 24 833029 10063 109746183
Cross sensitivity reaction 24.27 9.95 6 833047 5561 109750685
Myopathy 24.26 9.95 101 832952 24859 109731387
Presyncope 24.25 9.95 243 832810 48644 109707602
Ankle arthroplasty 24.19 9.95 57 832996 2494 109753752
Lymphopenia 24.18 9.95 190 832863 39980 109716266
Status epilepticus 24.18 9.95 139 832914 31432 109724814
Pneumothorax 24.09 9.95 161 832892 35124 109721122
Jaundice 24.05 9.95 308 832745 58928 109697318
Pancytopenia 23.85 9.95 1861 831192 207752 109548494
Blood lactate dehydrogenase increased 23.85 9.95 216 832837 44118 109712128
Product administration error 23.84 9.95 173 832880 37044 109719202
Immunosuppressant drug level increased 23.83 9.95 32 833021 11692 109744554
Hypomania 23.82 9.95 25 833028 10185 109746061
Hypoxic-ischaemic encephalopathy 23.80 9.95 19 833034 8828 109747418
Venoocclusive disease 23.80 9.95 9 833044 6341 109749905
Bacterial sepsis 23.80 9.95 26 833027 10400 109745846
Hypermethioninaemia 23.68 9.95 12 833041 74 109756172
Gastric haemorrhage 23.63 9.95 53 833000 15862 109740384
Hepatitis acute 23.60 9.95 68 832985 18698 109737548
Joint injury 23.56 9.95 428 832625 39566 109716680
Myocardial ischaemia 23.51 9.95 112 832941 26572 109729674
Dyspnoea exertional 23.50 9.95 600 832453 103460 109652786
Acute myeloid leukaemia recurrent 23.48 9.95 5 833048 5134 109751112
Panniculitis 23.44 9.95 199 832854 15383 109740863
Affect lability 23.10 9.95 68 832985 18569 109737677
Cleft lip and palate 23.01 9.95 28 833025 704 109755542
Respiration abnormal 22.90 9.95 24 833029 9785 109746461
Acute graft versus host disease in intestine 22.86 9.95 7 833046 5632 109750614
Liver disorder 22.83 9.95 1300 831753 140943 109615303
COVID-19 pneumonia 22.68 9.95 175 832878 36968 109719278
Blood urea increased 22.59 9.95 285 832768 54672 109701574
Hepatitis cholestatic 22.57 9.95 63 832990 17503 109738743
Sinus tachycardia 22.55 9.95 220 832833 44273 109711973
Tenosynovitis stenosans 22.52 9.95 69 832984 3534 109752712
Polyuria 22.51 9.95 64 832989 17674 109738572
Progressive multifocal leukoencephalopathy 22.43 9.95 104 832949 24852 109731394
Hepatic encephalopathy 22.40 9.95 123 832930 28133 109728113
Colitis 22.31 9.95 593 832460 101730 109654516
Foot fracture 22.20 9.95 292 832761 25254 109730992
Loose body in joint 22.15 9.95 39 833014 1381 109754865
Ventricular arrhythmia 22.10 9.95 26 833027 10061 109746185
Human herpesvirus 6 infection 22.01 9.95 11 833042 6570 109749676
Hyperprolactinaemia 21.98 9.95 11 833042 6564 109749682
Capillary leak syndrome 21.97 9.95 5 833048 4903 109751343
Exposure via ingestion 21.92 9.95 5 833048 4895 109751351
Brain injury 21.58 9.95 43 833010 13433 109742813
Hydrops foetalis 21.57 9.95 28 833025 753 109755493
Immune-mediated enterocolitis 21.53 9.95 27 833026 10158 109746088
Bronchitis 21.45 9.95 1415 831638 155617 109600629
Haematuria 21.41 9.95 469 832584 82536 109673710
Visual acuity reduced 21.37 9.95 148 832905 32025 109724221
Weight decreased 21.35 9.95 3920 829133 464137 109292109
Vascular stent thrombosis 21.31 9.95 3 833050 4158 109752088
Nasal oedema 21.28 9.95 105 832948 6734 109749512
Pain in jaw 21.19 9.95 265 832788 50912 109705334
Walking aid user 21.13 9.95 285 832768 24790 109731456
Right ventricular failure 21.12 9.95 112 832941 25842 109730404
Arterial occlusive disease 21.12 9.95 53 833000 15255 109740991
Hepatocellular carcinoma 21.08 9.95 26 833027 9854 109746392
Transplant dysfunction 21.04 9.95 19 833034 8309 109747937
Amyloid arthropathy 21.04 9.95 42 833011 1638 109754608
Frequent bowel movements 21.04 9.95 695 832358 70695 109685551
Breast cancer stage I 20.98 9.95 15 833038 7372 109748874
Epilepsy 20.85 9.95 939 832114 99270 109656976
Skin papilloma 20.84 9.95 105 832948 6791 109749455
Nail operation 20.80 9.95 42 833011 1652 109754594
Intervertebral disc degeneration 20.73 9.95 218 832835 17867 109738379
Fracture delayed union 20.68 9.95 49 833004 2152 109754094
Linear IgA disease 20.61 9.95 4 833049 4385 109751861
Ultrasound antenatal screen 20.58 9.95 26 833027 680 109755566
Postoperative wound infection 20.52 9.95 195 832858 15558 109740688
Systemic candida 20.50 9.95 27 833026 9947 109746299
Heparin-induced thrombocytopenia 20.48 9.95 34 833019 11390 109744856
Dysphonia 20.46 9.95 426 832627 75503 109680743
Spondylitis 20.46 9.95 151 832902 11187 109745059
Bradypnoea 20.38 9.95 21 833032 8628 109747618
Polyhydramnios 20.34 9.95 45 833008 1888 109754358
Oropharyngeal pain 20.31 9.95 1229 831824 134047 109622199
Osteopenia 20.21 9.95 256 832797 21953 109734293
Mucocutaneous ulceration 20.19 9.95 27 833026 748 109755498
Therapy non-responder 20.16 9.95 1410 831643 155897 109600349
Toxic optic neuropathy 20.11 9.95 36 833017 1292 109754954
Full blood count abnormal 20.05 9.95 299 832754 55753 109700493
Oesophageal carcinoma 20.02 9.95 35 833018 11489 109744757
Human antichimeric antibody positive 19.98 9.95 42 833011 1700 109754546
Eosinophil count increased 19.98 9.95 86 832967 20972 109735274
Poor venous access 19.96 9.95 277 832776 24245 109732001
Adverse drug reaction 19.80 9.95 979 832074 104580 109651666
Congestive cardiomyopathy 19.79 9.95 49 833004 14170 109742076
Neuritis 19.77 9.95 16 833037 7383 109748863
Pulmonary hypertension 19.60 9.95 295 832758 54925 109701321
Palmoplantar keratoderma 19.59 9.95 8 833045 5379 109750867
Colitis microscopic 19.56 9.95 45 833008 13349 109742897
Haematemesis 19.56 9.95 320 832733 58788 109697458
Metastasis 19.56 9.95 20 833033 8247 109747999
Product administered to patient of inappropriate age 19.52 9.95 19 833034 8017 109748229
Blood pressure increased 19.52 9.95 2228 830825 256145 109500101
Product prescribing issue 19.40 9.95 42 833011 12730 109743516
Hypoalbuminaemia 19.38 9.95 133 832920 28841 109727405
Sputum discoloured 19.33 9.95 127 832926 27818 109728428
Psychotic symptom 19.31 9.95 3 833050 3864 109752382
Neurological symptom 19.31 9.95 57 832996 15551 109740695
Transaminases increased 19.10 9.95 349 832704 63041 109693205
Alanine aminotransferase increased 19.10 9.95 1161 831892 182612 109573634
Pseudomonal sepsis 19.10 9.95 24 833029 9022 109747224
Appendicitis 19.08 9.95 311 832742 28153 109728093
Skin burning sensation 19.00 9.95 92 832961 21733 109734513
Ulcer 18.99 9.95 442 832611 42674 109713572
Eosinophilic granulomatosis with polyangiitis 18.98 9.95 32 833021 10654 109745592
Dyspepsia 18.95 9.95 1678 831375 189287 109566959
Systemic inflammatory response syndrome 18.91 9.95 44 833009 12999 109743247
Pulmonary function test abnormal 18.89 9.95 7 833046 4993 109751253
Eczema 18.78 9.95 408 832645 71885 109684361
Affective disorder 18.76 9.95 35 833018 11206 109745040
Erectile dysfunction 18.72 9.95 74 832979 18482 109737764
Mucosal inflammation 18.72 9.95 566 832487 95575 109660671
Laryngeal oedema 18.71 9.95 28 833025 9779 109746467
Aspartate aminotransferase increased 18.69 9.95 999 832054 158937 109597309
Methaemoglobinaemia 18.66 9.95 25 833028 9143 109747103
Anhedonia 18.61 9.95 57 832996 15371 109740875
Swelling face 18.60 9.95 541 832512 91780 109664466
Kidney transplant rejection 18.56 9.95 39 833014 11948 109744298
Laryngospasm 18.55 9.95 6 833047 4662 109751584
Metastases to lymph nodes 18.52 9.95 55 832998 14977 109741269
Cyst 18.51 9.95 198 832855 16298 109739948
Foot operation 18.47 9.95 106 832947 7207 109749039
Pulmonary pain 18.45 9.95 95 832958 6198 109750048
Hypocalcaemia 18.43 9.95 364 832689 65002 109691244
Product label confusion 18.39 9.95 256 832797 22421 109733825
Product dose omission issue 18.38 9.95 2132 830921 319650 109436596
Ingrown hair 18.34 9.95 26 833027 762 109755484
Trisomy 18 18.31 9.95 23 833030 598 109755648
Acute pulmonary oedema 18.30 9.95 66 832987 16930 109739316
Vertigo 18.27 9.95 506 832547 86364 109669882
Lymphatic fistula 18.27 9.95 37 833016 1458 109754788
Anti-neutrophil cytoplasmic antibody positive vasculitis 18.20 9.95 9 833044 5408 109750838
Dysgeusia 18.17 9.95 395 832658 69590 109686656
Anosmia 18.14 9.95 42 833011 12430 109743816
Type I hypersensitivity 18.13 9.95 13 833040 6380 109749866
Femoral hernia incarcerated 18.04 9.95 37 833016 1472 109754774
Accidental overdose 18.03 9.95 278 832775 51556 109704690
Anticholinergic syndrome 17.92 9.95 5 833048 4275 109751971
Hypertriglyceridaemia 17.88 9.95 62 832991 16092 109740154
Haemoglobin decreased 17.87 9.95 2138 830915 246589 109509657
Rales 17.85 9.95 111 832942 24628 109731618
Incoherent 17.83 9.95 22 833031 8336 109747910
Purpura 17.82 9.95 109 832944 24279 109731967
Brain natriuretic peptide increased 17.75 9.95 36 833017 11173 109745073
Antineutrophil cytoplasmic antibody positive 17.72 9.95 8 833045 5068 109751178
Device occlusion 17.69 9.95 57 832996 15128 109741118
Creatinine renal clearance increased 17.68 9.95 3 833050 3622 109752624
Maternal exposure during breast feeding 17.68 9.95 71 832982 4167 109752079
Hydrocephalus 17.58 9.95 32 833021 10343 109745903
Blindness 17.51 9.95 182 832871 36177 109720069
Prostatic specific antigen increased 17.50 9.95 43 833010 12468 109743778
Vomiting 17.48 9.95 6378 826675 904297 108851949
Joint noise 17.48 9.95 81 832972 5062 109751184
Acute lymphocytic leukaemia recurrent 17.45 9.95 11 833042 5776 109750470
Fear of injection 17.42 9.95 121 832932 8790 109747456
Incorrect dose administered 17.37 9.95 622 832431 103019 109653227
Psychiatric decompensation 17.32 9.95 11 833042 5754 109750492
Pericardial effusion 17.25 9.95 315 832738 56902 109699344
Salivary hypersecretion 17.24 9.95 70 832983 17351 109738895
Atrioventricular block 17.22 9.95 67 832986 16810 109739436
Cholangitis 17.21 9.95 64 832989 16271 109739975
Ulcer haemorrhage 17.19 9.95 252 832801 22319 109733927
Foetal exposure during pregnancy 17.17 9.95 106 832947 7399 109748847
Left ventricular dysfunction 17.16 9.95 105 832948 23388 109732858
Short stature 17.14 9.95 30 833023 1057 109755189
Type 1 diabetes mellitus 17.10 9.95 26 833027 9021 109747225
Long QT syndrome 17.09 9.95 17 833036 7101 109749145
Breast feeding 17.07 9.95 24 833029 698 109755548
Therapy interrupted 17.06 9.95 268 832785 49554 109706692
Body height below normal 17.05 9.95 44 833009 2040 109754206
Osteonecrosis 17.03 9.95 167 832886 33574 109722672
Hepatotoxicity 17.00 9.95 356 832697 63044 109693202
Drug screen positive 16.95 9.95 14 833039 6396 109749850
Wound infection pseudomonas 16.81 9.95 48 833005 2363 109753883
Amylase increased 16.76 9.95 44 833009 12475 109743771
Hypertensive crisis 16.74 9.95 111 832942 24261 109731985
Therapeutic response decreased 16.68 9.95 888 832165 95611 109660635
Concomitant disease aggravated 16.67 9.95 65 832988 16299 109739947
Lipase increased 16.67 9.95 78 832975 18594 109737652
Genital haemorrhage 16.65 9.95 18 833035 7234 109749012
Hypervolaemia 16.62 9.95 267 832786 49193 109707053
Skin cancer 16.61 9.95 206 832847 17578 109738668
Blood glucose decreased 16.60 9.95 142 832911 29346 109726900
Dyslipidaemia 16.53 9.95 63 832990 15902 109740344
Temperature intolerance 16.50 9.95 52 833001 13898 109742348
Deep vein thrombosis 16.49 9.95 873 832180 139014 109617232
Total lung capacity increased 16.43 9.95 9 833044 5103 109751143
Intraocular pressure increased 16.33 9.95 36 833017 10840 109745406
Sudden death 16.31 9.95 112 832941 24283 109731963
Epstein-Barr virus associated lymphoproliferative disorder 16.10 9.95 8 833045 4794 109751452
Hypophagia 16.09 9.95 289 832764 52337 109703909
Post procedural infection 16.08 9.95 167 832886 13642 109742604
Depressive symptom 16.08 9.95 24 833029 8390 109747856
Foetal distress syndrome 16.03 9.95 22 833031 625 109755621
Hypoglycaemic coma 16.03 9.95 11 833042 5522 109750724
Injection site warmth 15.99 9.95 201 832852 17204 109739042
Epidermal necrosis 15.99 9.95 55 832998 2995 109753251
Hyperthyroidism 15.99 9.95 142 832911 29119 109727127
Enterococcal infection 15.96 9.95 89 832964 20277 109735969
Procedural pain 15.93 9.95 181 832872 35384 109720862
Bronchial secretion retention 15.92 9.95 9 833044 5015 109751231
Swollen tongue 15.87 9.95 340 832713 60022 109696224
Placental disorder 15.87 9.95 28 833025 993 109755253
Staphylococcal infection 15.87 9.95 403 832650 69541 109686705
Toxic encephalopathy 15.78 9.95 60 832993 15154 109741092
Hypotonia 15.75 9.95 63 832990 15682 109740564
Multiple allergies 15.74 9.95 44 833009 12219 109744027
Cytomegalovirus colitis 15.69 9.95 18 833035 7043 109749203
Renal injury 15.65 9.95 80 832973 18633 109737613
Small for dates baby 15.64 9.95 22 833031 640 109755606
Polydipsia 15.61 9.95 21 833032 7667 109748579
Hepatic necrosis 15.60 9.95 32 833021 9890 109746356
Syringe issue 15.59 9.95 30 833023 9495 109746751
Malignant melanoma 15.49 9.95 195 832858 16696 109739550
Tetany 15.49 9.95 4 833049 3600 109752646
Sneezing 15.44 9.95 160 832893 31824 109724422
Nightmare 15.43 9.95 203 832850 38660 109717586
Bradyarrhythmia 15.40 9.95 9 833044 4925 109751321
Cardiac septal defect 15.38 9.95 27 833026 954 109755292
Injection site bruising 15.35 9.95 500 832553 50763 109705483
Extra dose administered 15.34 9.95 44 833009 12115 109744131
Epstein-Barr viraemia 15.33 9.95 4 833049 3575 109752671
Staphylococcal bacteraemia 15.32 9.95 69 832984 16619 109739627
Gastric cancer 15.27 9.95 38 833015 10970 109745276
Antibody test positive 15.27 9.95 55 832998 3065 109753181
Spinal osteoarthritis 15.24 9.95 225 832828 19958 109736288
Lower respiratory tract congestion 15.19 9.95 74 832979 4722 109751524
Immune thrombocytopenia 15.17 9.95 103 832950 22391 109733855
Induced labour 15.16 9.95 26 833027 901 109755345
Renal cancer 15.13 9.95 49 833004 12985 109743261
Stillbirth 15.12 9.95 68 832985 4196 109752050
Productive cough 15.10 9.95 705 832348 113600 109642646
Wrong product administered 15.08 9.95 38 833015 10922 109745324
Immune-mediated hepatitis 15.03 9.95 17 833036 6694 109749552
Infection reactivation 14.94 9.95 6 833047 4075 109752171
Benign ovarian tumour 14.93 9.95 18 833035 448 109755798
Head injury 14.86 9.95 231 832822 42786 109713460
Accidental exposure to product by child 14.84 9.95 3 833050 3195 109753051
Pharyngeal swelling 14.84 9.95 44 833009 11988 109744258
Autonomic nervous system imbalance 14.83 9.95 13 833040 5767 109750479
Clostridium test positive 14.80 9.95 38 833015 10855 109745391
Metabolic disorder 14.80 9.95 36 833017 10474 109745772
Treatment noncompliance 14.63 9.95 428 832625 72562 109683684
Dermatitis bullous 14.62 9.95 75 832978 17454 109738792
Diaphragmatic disorder 14.59 9.95 39 833014 1847 109754399
Hallucinations, mixed 14.56 9.95 27 833026 8666 109747580
Taste disorder 14.55 9.95 617 832436 64770 109691476
Plasma cell myeloma recurrent 14.54 9.95 19 833034 7023 109749223
Acute lung injury 14.53 9.95 3 833050 3148 109753098
Steroid diabetes 14.49 9.95 11 833042 5243 109751003
Hypertransaminasaemia 14.47 9.95 115 832938 24140 109732106
Haemorrhage in pregnancy 14.46 9.95 36 833017 1632 109754614
Complications of transplanted kidney 14.44 9.95 21 833032 7421 109748825
Gait disturbance 14.42 9.95 2346 830707 275862 109480384
Reversible cerebral vasoconstriction syndrome 14.42 9.95 9 833044 4752 109751494
Ileus paralytic 14.42 9.95 43 833010 11694 109744552
Bone density abnormal 14.42 9.95 63 832990 3840 109752406
Varicella zoster virus infection 14.40 9.95 16 833037 6352 109749894
Kounis syndrome 14.40 9.95 14 833039 5911 109750335
Vasculitis 14.39 9.95 187 832866 35686 109720560
Bradykinesia 14.38 9.95 38 833015 10750 109745496
Neoplasm recurrence 14.37 9.95 11 833042 5221 109751025
Abdominal pain upper 14.37 9.95 2909 830144 346202 109410044
Compartment syndrome 14.32 9.95 14 833039 5896 109750350
Blood folate increased 14.32 9.95 20 833033 578 109755668
Granulocyte count decreased 14.29 9.95 6 833047 3968 109752278
Device loosening 14.28 9.95 24 833029 818 109755428
Injection site rash 14.28 9.95 252 832801 23167 109733079
Endodontic procedure 14.27 9.95 54 832999 3082 109753164
Abortion missed 14.21 9.95 34 833019 1503 109754743
Cervical incompetence 14.16 9.95 19 833034 528 109755718
Radiation inflammation 14.10 9.95 27 833026 1021 109755225
Neutrophilia 14.06 9.95 36 833017 10293 109745953
Porphyria acute 14.04 9.95 209 832844 18571 109737675
Atrial flutter 14.03 9.95 116 832937 24146 109732100
Abortion incomplete 14.01 9.95 3 833050 3069 109753177
Hand fracture 13.99 9.95 107 832946 8015 109748231
Vein disorder 13.99 9.95 88 832965 6182 109750064
Extradural haematoma 13.99 9.95 4 833049 3365 109752881
Secondary adrenocortical insufficiency 13.97 9.95 8 833045 4426 109751820
Extravascular haemolysis 13.92 9.95 17 833036 429 109755817
Liver abscess 13.91 9.95 23 833030 7716 109748530
Foetal heart rate abnormal 13.87 9.95 21 833032 654 109755592
Pain of skin 13.87 9.95 91 832962 19938 109736308
Product monitoring error 13.86 9.95 29 833024 8898 109747348
Deformity 13.86 9.95 127 832926 10033 109746213
Bone density increased 13.84 9.95 26 833027 969 109755277
Vitamin B6 increased 13.83 9.95 7 833046 43 109756203
Enterobacter infection 13.81 9.95 14 833039 5797 109750449
Retinal haemorrhage 13.81 9.95 32 833021 9469 109746777
Arteriospasm coronary 13.76 9.95 30 833023 9070 109747176
Anal fissure 13.72 9.95 124 832929 9757 109746489
Sickle cell anaemia 13.68 9.95 23 833030 784 109755462
Insurance issue 13.68 9.95 38 833015 10574 109745672
Cardiac dysfunction 13.68 9.95 16 833037 6207 109750039
Haematocrit decreased 13.63 9.95 619 832434 65498 109690748
Complication of device removal 13.63 9.95 9 833044 4611 109751635
Cough 13.61 9.95 3175 829878 458466 109297780
Nervous system disorder 13.61 9.95 163 832890 31558 109724688
Urinary incontinence 13.57 9.95 271 832782 48316 109707930
Nail injury 13.56 9.95 23 833030 790 109755456
Viraemia 13.51 9.95 7 833046 4095 109752151
Obsessive-compulsive disorder 13.50 9.95 21 833032 7220 109749026
Tension headache 13.50 9.95 33 833020 9585 109746661
Butterfly rash 13.50 9.95 41 833012 2090 109754156
Complication of device insertion 13.48 9.95 29 833024 8809 109747437
Placental insufficiency 13.47 9.95 30 833023 1264 109754982
Peritoneal dialysis complication 13.42 9.95 46 833007 2500 109753746
Nephrotic syndrome 13.42 9.95 56 832997 13775 109742471
Pancreatic steatosis 13.42 9.95 37 833016 1785 109754461
Post-traumatic stress disorder 13.41 9.95 18 833035 6578 109749668
Epstein-Barr virus infection reactivation 13.40 9.95 7 833046 4077 109752169
Joint lock 13.32 9.95 58 832995 3530 109752716
Heart rate irregular 13.20 9.95 345 832708 33929 109722317
Dysuria 13.14 9.95 349 832704 59882 109696364
Central nervous system mass 13.13 9.95 23 833030 811 109755435
Hepatitis fulminant 13.13 9.95 28 833025 8532 109747714
Breast cancer stage II 13.12 9.95 284 832769 27091 109729155
Vascular purpura 13.08 9.95 6 833047 3765 109752481
Tubulointerstitial nephritis 13.07 9.95 310 832743 53974 109702272
Injection site swelling 13.07 9.95 580 832473 61210 109695036
Breast cancer female 13.04 9.95 49 833004 12419 109743827
Wall motion score index abnormal 12.99 9.95 23 833030 818 109755428
Delayed graft function 12.96 9.95 8 833045 4249 109751997
Pneumonia fungal 12.96 9.95 62 832991 14692 109741554
Lacrimal disorder 12.94 9.95 18 833035 518 109755728
Eyelid oedema 12.90 9.95 65 832988 15197 109741049
Drug abuser 12.90 9.95 13 833040 5396 109750850
Lymph gland infection 12.88 9.95 20 833033 637 109755609
Embolism 12.86 9.95 71 832982 16218 109740028
Catarrh 12.84 9.95 97 832956 7238 109749008
Myoglobin blood increased 12.82 9.95 8 833045 4224 109752022
Injection site extravasation 12.82 9.95 125 832928 10044 109746202
Wrong patient received product 12.79 9.95 19 833034 6655 109749591
Herpes zoster 12.78 9.95 965 832088 107414 109648832
Hepatitis C 12.77 9.95 50 833003 12523 109743723
Parvovirus B19 infection 12.77 9.95 3 833050 2878 109753368
Pancreatic carcinoma 12.77 9.95 63 832990 14809 109741437
Ventricular extrasystoles 12.76 9.95 109 832944 22532 109733714
Corneal oedema 12.75 9.95 4 833049 3169 109753077
Arteriosclerosis 12.75 9.95 122 832931 24645 109731601
Electrolyte imbalance 12.74 9.95 199 832854 36829 109719417
Prerenal failure 12.74 9.95 9 833044 4450 109751796
Panic attack 12.69 9.95 148 832905 28792 109727454
Bone marrow failure 12.67 9.95 335 832718 57513 109698733
Swollen joint count 12.64 9.95 110 832943 8564 109747682
Paronychia 12.63 9.95 42 833011 11039 109745207
Ligament rupture 12.59 9.95 62 832991 3973 109752273
Stress 12.59 9.95 939 832114 104409 109651837
Post procedural haemorrhage 12.59 9.95 67 832986 15445 109740801
Asthenia 12.58 9.95 4834 828219 684165 109072081
Leukoencephalopathy 12.56 9.95 32 833021 9163 109747083
Increased appetite 12.54 9.95 64 832989 14913 109741333
Hypothalamo-pituitary disorder 12.54 9.95 3 833050 2843 109753403
Tooth disorder 12.54 9.95 301 832752 29208 109727038
Schizoaffective disorder 12.52 9.95 4 833049 3132 109753114
Ear pain 12.47 9.95 505 832548 52721 109703525
Liver transplant rejection 12.44 9.95 7 833046 3911 109752335
Bone cyst 12.44 9.95 57 832996 3546 109752700
Blood loss anaemia 12.43 9.95 82 832971 17943 109738303
Cryptococcosis 12.39 9.95 10 833043 4621 109751625
Hypopituitarism 12.36 9.95 9 833044 4381 109751865
Inadequate analgesia 12.34 9.95 12 833041 5065 109751181
Cyst rupture 12.34 9.95 23 833030 852 109755394
Hyperventilation 12.32 9.95 31 833022 8916 109747330
Cancer pain 12.29 9.95 20 833033 6752 109749494
Areflexia 12.27 9.95 20 833033 6749 109749497
Cystoid macular oedema 12.24 9.95 3 833050 2797 109753449
Hepatic cancer 12.23 9.95 43 833010 11113 109745133
Rash morbilliform 12.20 9.95 26 833027 7925 109748321
Infusion site reaction 12.15 9.95 194 832859 17488 109738758
Ascites 12.14 9.95 573 832480 92235 109664011
Infusion site pain 12.13 9.95 79 832974 17340 109738906
Pneumomediastinum 12.12 9.95 12 833041 5024 109751222
Cardiac tamponade 12.11 9.95 44 833009 11263 109744983
Anaesthetic complication 12.10 9.95 6 833047 3600 109752646
Mycobacterium chelonae infection 12.05 9.95 4 833049 3056 109753190
Product dose omission in error 12.02 9.95 116 832937 23396 109732850
Troponin increased 12.00 9.95 155 832898 29611 109726635
Persecutory delusion 11.97 9.95 18 833035 6273 109749973
Hepatitis B 11.96 9.95 35 833018 9577 109746669
Cushingoid 11.96 9.95 138 832915 11574 109744672
Vascular device infection 11.96 9.95 74 832979 16438 109739808
Peripheral sensory neuropathy 11.95 9.95 75 832978 16605 109739641
Haemorrhagic transformation stroke 11.90 9.95 4 833049 3033 109753213
Troponin T increased 11.90 9.95 9 833044 4297 109751949
Strongyloidiasis 11.87 9.95 12 833041 4974 109751272
Pallor 11.85 9.95 329 832724 56138 109700108
Knee operation 11.82 9.95 92 832961 6930 109749316
Accessory spleen 11.78 9.95 11 833042 202 109756044
Coccydynia 11.77 9.95 44 833009 2497 109753749
Human anti-human antibody test 11.77 9.95 15 833038 396 109755850
Transient aphasia 11.75 9.95 20 833033 689 109755557
Defaecation disorder 11.65 9.95 22 833031 823 109755423
Renal tubular disorder 11.64 9.95 24 833029 7405 109748841
Pharyngitis streptococcal 11.64 9.95 152 832901 13125 109743121
Oligoarthritis 11.60 9.95 21 833032 760 109755486
Tender joint count increased 11.57 9.95 15 833038 403 109755843
Cold sweat 11.56 9.95 108 832945 21923 109734323
Fibroadenoma of breast 11.54 9.95 20 833033 699 109755547
Hospitalisation 11.54 9.95 920 832133 141573 109614673
Dizziness 11.53 9.95 4916 828137 693277 109062969
Breast abscess 11.50 9.95 34 833019 1707 109754539
Vitamin B6 deficiency 11.49 9.95 18 833035 578 109755668
Iritis 11.47 9.95 67 832986 4585 109751661
Autoimmune hepatitis 11.43 9.95 65 832988 14739 109741507
Candida sepsis 11.43 9.95 4 833049 2957 109753289
Coronary artery stenosis 11.40 9.95 59 832994 13699 109742547
Behaviour disorder 11.38 9.95 36 833017 9611 109746635
Nervousness 11.38 9.95 202 832851 36649 109719597
Brain abscess 11.38 9.95 21 833032 6753 109749493
Tonic clonic movements 11.38 9.95 4 833049 2948 109753298
Hepatitis E antibody positive 11.37 9.95 12 833041 257 109755989
Lower gastrointestinal haemorrhage 11.33 9.95 87 832966 18399 109737847
Joint warmth 11.31 9.95 38 833015 2044 109754202
Threatened labour 11.28 9.95 19 833034 649 109755597
Skin necrosis 11.23 9.95 226 832827 21286 109734960
Diabetes mellitus 11.19 9.95 623 832430 98758 109657488
Cogwheel rigidity 11.19 9.95 7 833046 3691 109752555
Alcohol interaction 11.17 9.95 7 833046 3687 109752559
Airway remodelling 11.14 9.95 23 833030 919 109755327
Thirst 11.14 9.95 107 832946 21600 109734646
Blood phosphorus increased 11.12 9.95 179 832874 16161 109740085
Bone fissure 11.09 9.95 18 833035 596 109755650
Neutropenic colitis 11.06 9.95 28 833025 8037 109748209
Aplasia 11.06 9.95 27 833026 7846 109748400
Oesophageal fibrosis 11.05 9.95 10 833043 176 109756070
Tooth abscess 11.04 9.95 201 832852 18588 109737658
Mental impairment 11.03 9.95 113 832940 22526 109733720
Personality change 11.02 9.95 44 833009 10958 109745288
Terminal state 10.99 9.95 16 833037 5651 109750595
Tumour haemorrhage 10.99 9.95 14 833039 5231 109751015
Vertebral osteophyte 10.98 9.95 17 833036 540 109755706
Carcinoid tumour of the small bowel 10.96 9.95 15 833038 425 109755821
Investigation abnormal 10.94 9.95 42 833011 2414 109753832
Twin pregnancy 10.88 9.95 23 833030 935 109755311
Red blood cell count decreased 10.87 9.95 604 832449 65319 109690927
Hemianopia 10.86 9.95 4 833049 2864 109753382
Functional gastrointestinal disorder 10.85 9.95 18 833035 6031 109750215
Ischaemic cardiomyopathy 10.85 9.95 28 833025 7983 109748263
Accident 10.84 9.95 44 833009 10908 109745338
Loss of libido 10.84 9.95 5 833048 3128 109753118
Poor quality device used 10.83 9.95 4 833049 2859 109753387
Coronary artery bypass 10.82 9.95 18 833035 6024 109750222
Catatonia 10.81 9.95 46 833007 11254 109744992
Arteriosclerosis coronary artery 10.80 9.95 129 832924 24989 109731257
Back pain 10.80 9.95 2553 830500 368443 109387803
Choking 10.79 9.95 68 832985 15042 109741204
C-reactive protein decreased 10.78 9.95 47 833006 2862 109753384
Staphylococcal sepsis 10.77 9.95 82 832971 17372 109738874
Confusional state 10.75 9.95 3809 829244 464871 109291375
Decreased insulin requirement 10.75 9.95 9 833044 142 109756104
Upper gastrointestinal haemorrhage 10.74 9.95 291 832762 49805 109706441
Lip oedema 10.73 9.95 26 833027 7574 109748672
Angina unstable 10.71 9.95 76 832977 16356 109739890
Necrotising fasciitis 10.69 9.95 26 833027 7565 109748681
Pleuritic pain 10.69 9.95 176 832877 15964 109740282
Rhinovirus infection 10.67 9.95 49 833004 11740 109744506
Cholestasis of pregnancy 10.65 9.95 27 833026 1238 109755008
Myofascial pain syndrome 10.65 9.95 43 833010 2530 109753716
Gestational hypertension 10.61 9.95 39 833014 2195 109754051
Pancreatitis 10.60 9.95 586 832467 92947 109663299
Escherichia bacteraemia 10.60 9.95 40 833013 10124 109746122
Middle insomnia 10.55 9.95 101 832952 20401 109735845
Dactylitis 10.50 9.95 60 832993 4073 109752173
Alcohol abuse 10.49 9.95 13 833040 4916 109751330
Apnoea 10.47 9.95 60 832993 13579 109742667
Hepatic cyst 10.47 9.95 97 832956 7686 109748560
Quadriparesis 10.46 9.95 12 833041 4695 109751551
Maternal exposure during delivery 10.44 9.95 7 833046 3558 109752688
Drooling 10.42 9.95 24 833029 7115 109749131
Dermatitis exfoliative 10.37 9.95 47 833006 11300 109744946
Shortened cervix 10.35 9.95 10 833043 192 109756054
Disorganised speech 10.35 9.95 6 833047 3297 109752949
Device breakage 10.34 9.95 61 832992 13708 109742538
Eye movement disorder 10.33 9.95 38 833015 9690 109746556
Apraxia 10.30 9.95 7 833046 3533 109752713
Skin graft failure 10.30 9.95 11 833042 239 109756007
Abortion threatened 10.27 9.95 15 833038 452 109755794
Labyrinthitis 10.24 9.95 48 833005 3014 109753232
Wrong technique in device usage process 10.23 9.95 23 833030 6878 109749368
Burns second degree 10.21 9.95 96 832957 7637 109748609
Delivery 10.19 9.95 23 833030 978 109755268
Fanconi syndrome 10.19 9.95 7 833046 3512 109752734
Musculoskeletal disorder 10.19 9.95 233 832820 22431 109733815
Cerebellar haemorrhage 10.17 9.95 6 833047 3265 109752981
Acquired gene mutation 10.16 9.95 4 833049 2750 109753496
Device issue 10.14 9.95 191 832862 34344 109721902
Hydronephrosis 10.13 9.95 103 832950 20562 109735684
Upper respiratory tract irritation 10.08 9.95 11 833042 245 109756001
Skin weeping 10.08 9.95 8 833045 3727 109752519
Immune-mediated myocarditis 10.07 9.95 7 833046 3491 109752755
Hypertension 10.05 9.95 4123 828930 505961 109250285
Hepatitis E virus test positive 10.04 9.95 12 833041 296 109755950
Bundle branch block right 10.02 9.95 53 833000 12238 109744008
Rotator cuff syndrome 9.99 9.95 180 832873 16614 109739632
Intestinal ischaemia 9.98 9.95 76 832977 16103 109740143
Cerebral haematoma 9.98 9.95 38 833015 9594 109746652

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA02 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
FDA Chemical/Ingredient N0000005657 Vitamin B 6
FDA Chemical/Ingredient N0000175452 Analogs/Derivatives
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:50646 bone density conservation agent
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:53784 antispasmodic drug
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:75772 <em>Saccharomyces cerevisiae </em> metabolite
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:231911 renoprotective agent
FDA EPC N0000192800 Vitamin B6 Analog

Related Drugs by ATC class:

A11HA Other plain vitamin preparations 10 drugs
biotincalcium pantothenatedexpanthenolinositolnicotinamidepantethinepyridoxal phosphateriboflavintocofersolanVitamin E

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pregnancy, function indication 289908002
Vitamin B6 deficiency indication 386080007 DOID:8455
Breastfeeding (mother) indication 413712001
Drug-Induced Pyridoxine Deficiency indication
Pyridoxine-Dependent Seizure indication
Nutritional disorder contraindication 2492009 DOID:374
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Hyperkalemia contraindication 14140009
Gastroenteritis contraindication 25374005 DOID:2326
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Acute hepatitis contraindication 37871000
Hemosiderosis contraindication 39011001 DOID:12119
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Gastrectomy contraindication 53442002
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Schizophrenia contraindication 58214004 DOID:5419
Acute nephropathy contraindication 58574008
Leber's optic atrophy contraindication 58610003 DOID:705
Metabolic acidosis contraindication 59455009
Hepatic failure contraindication 59927004
Hemolytic anemia contraindication 61261009 DOID:583
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Poisoning by acetaminophen contraindication 70273001
Diabetes mellitus contraindication 73211009 DOID:9351
Gastrointestinal hemorrhage contraindication 74474003
Atrophic gastritis contraindication 84568007 DOID:8929
Autoimmune disease contraindication 85828009
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Gastrointestinal obstruction contraindication 126765001
Acute hepatic failure contraindication 197270009
Impaired renal function disorder contraindication 197663003
Gastroparesis contraindication 235675006
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Esophageal dysmotility contraindication 266434009 DOID:9192
Diabetic - poor control contraindication 268519009
Peripheral nerve disease contraindication 302226006
Primary adrenocortical insufficiency contraindication 373662000
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Ketoacidosis in diabetes mellitus contraindication 420422005 DOID:1837
Diabetic peripheral neuropathy contraindication 424736006
Slow acetylator due to N-acetyltransferase enzyme variant contraindication 425079005
Chronic Hepatic Disease contraindication
Genitourinary Tract Infections contraindication
Repeated Blood Transfusions contraindication
Prolonged-Severe Nausea and Vomiting contraindication
Esophageal Compression contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.98 acidic
pKa2 13.8 acidic
pKa3 4.94 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9089489 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9375404 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9526703 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9937132 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML MULTIPLE VITAMINS INJECTION ADULT APOTEX A210672 April 9, 2026 RX SOLUTION INTRAVENOUS Dec. 1, 2026 COMPETITIVE GENERIC THERAPY
80MG/VIAL;0.02MG/VIAL;400 IU/VIAL;0.001MG/VIAL;5MG/VIAL;0.14MG/VIAL;17MG/VIAL;1MG/VIAL;1.4MG/VIAL;1.2MG/VIAL;7 IU/VIAL;2,300 IU/VIAL;0.2MG/VIAL MULTIPLE VITAMINS INJECTION PEDIATRIC APOTEX A210671 April 21, 2026 RX INJECTABLE INTRAVENOUS Dec. 21, 2026 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Serine hydroxymethyltransferase, cytosolic Enzyme WOMBAT-PK
Pyridoxine-5'-phosphate oxidase Enzyme WOMBAT-PK
Pyridoxal phosphate phosphatase Enzyme WOMBAT-PK
Pyridoxal kinase Kinase WOMBAT-PK
Cystathionine beta-synthase Enzyme WOMBAT-PK
Phosphoserine aminotransferase Enzyme WOMBAT-PK

External reference:

IDSource
4019922 VUID
N0000148007 NUI
D02179 KEGG_DRUG
58-56-0 SECONDARY_CAS_RN
4017489 VANDF
4017779 VANDF
4018569 VANDF
4019922 VANDF
4021899 VANDF
C0034272 UMLSCUI
CHEBI:16709 CHEBI
CHEMBL1364 ChEMBL_ID
DB00165 DRUGBANK_ID
CHEMBL1200756 ChEMBL_ID
D011736 MESH_DESCRIPTOR_UI
1054 PUBCHEM_CID
2216 INN_ID
KV2JZ1BI6Z UNII
203164 RXNORM
35074 MMSL
4979 MMSL
4994 MMSL
5393 MMSL
5686 MMSL
6601 MMSL
d00412 MMSL
001058 NDDF
004538 NDDF
126227009 SNOMEDCT_US
430469009 SNOMEDCT_US
767286000 SNOMEDCT_US
D025101 MESH_DESCRIPTOR_UI
UEG PDB_CHEM_ID
KV2JZ1BI6Z INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 10 mg ORAL Unapproved drug other 12 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 25 mg ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 25 mg ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 25 mg ORAL Unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 20 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 20 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 20 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 20 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 20 mg ORAL Unapproved drug other 11 sections
Doxylamine Succinate and Pyridoxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-4615 TABLET, DELAYED RELEASE 10 mg ORAL ANDA 26 sections
Doxylamine succinate and pyridoxine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0591-2132 TABLET, DELAYED RELEASE 10 mg ORAL ANDA 24 sections
Doxylamine succinate and pyridoxine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0591-2132 TABLET, DELAYED RELEASE 10 mg ORAL ANDA 24 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 2.50 mg ORAL unapproved drug other 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 2.50 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OBCaplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 2.50 mg ORAL unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 2.50 mg ORAL UNAPPROVED DRUG OTHER 13 sections
VitafolUltra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 2.50 mg ORAL unapproved drug other 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 2.50 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite OneCaplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 25 mg ORAL unapproved drug other 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 2.50 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 2.50 mg ORAL unapproved drug other 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 5 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 25 mg ORAL UNAPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 12 mg ORAL UNAPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 25 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 50 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 10 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 25 mg ORAL Unapproved drug other 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 10 mg ORAL unapproved drug other 8 sections