phenylephrine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetic, phenethyl derivatives 2146 59-42-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • (-)-Phenylephrine
  • (-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol
  • (-)-m-Oxedrine
  • (-)-m-Synephrine
  • (R)-Phenylephrine
  • L-Phenylephedrine
  • mesatone
  • metaoxedrin
  • metaoxedrine
  • metasympatol
  • metasynephrine
  • mezaton
  • l-Phenylephrine
  • phenylephrine
  • phenylephrine hydrochloride
  • phenylephrine tannate
  • phenylephrine bitartrate
  • phenylephrine HCl
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
  • Molecular weight: 167.21
  • Formula: C9H13NO2
  • CLOGP: -0.09
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 52.49
  • ALOGS: -0.88
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
4 mg P
4 mg N
40 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.98 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 35 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPKAPK2,MTOR,NTRK2,PDK2,PDK4,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,ZAP70 41
kinase-selectivity-class AXL,BRAF,EIF2AK3,EPHB4,GRK2,MAP2K6,TEK 7
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Jan. 21, 1952 FDA ANI PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 615.54 9.45 80 554383 144978 89929006
Sinusitis 514.23 9.45 3727 550736 339361 89734623
Local anaesthetic systemic toxicity 400.65 9.45 256 554207 3244 90070740
Drug interaction 376.46 9.45 698 553765 275755 89798229
Acute kidney injury 372.44 9.45 885 553578 319502 89754482
Toxicity to various agents 337.80 9.45 791 553672 287055 89786929
Nasopharyngitis 286.17 9.45 3773 550690 403331 89670653
Lower respiratory tract infection 277.63 9.45 2543 551920 248116 89825868
Myelosuppression 246.52 9.45 22 554441 53569 90020415
Muscle injury 239.90 9.45 1876 552587 174778 89899206
Neutropenia 233.02 9.45 658 553805 224246 89849738
Irritable bowel syndrome 232.38 9.45 2110 552353 205338 89868646
Muscle spasticity 229.97 9.45 601 553862 34721 90039263
Peripheral swelling 225.26 9.45 3664 550799 409442 89664542
Gastrointestinal disorder 219.76 9.45 2470 551993 254217 89819767
Folliculitis 217.55 9.45 2056 552407 202297 89871687
Body temperature increased 208.40 9.45 675 553788 44035 90029949
Ear pain 204.41 9.45 796 553667 56906 90017078
Anaemia 200.49 9.45 1299 553164 351503 89722481
Maternal exposure during delivery 187.76 9.45 169 554294 3677 90070307
Hyponatraemia 187.14 9.45 331 554132 133207 89940777
Weight increased 179.40 9.45 3570 550893 414357 89659627
Drug abuse 178.33 9.45 145 554318 82202 89991782
Blood pressure diastolic abnormal 178.01 9.45 383 554080 19498 90054486
Back pain 174.93 9.45 2819 551644 314356 89759628
Ill-defined disorder 170.55 9.45 1806 552657 183085 89890899
Pancytopenia 168.60 9.45 298 554165 119965 89954019
Cardiac failure 159.28 9.45 265 554198 109231 89964753
Food allergy 159.24 9.45 427 554036 25051 90048933
Blood pressure systolic abnormal 158.34 9.45 361 554102 19117 90054867
Headache 155.45 9.45 6603 547860 856143 89217841
Blood pressure fluctuation 154.20 9.45 683 553780 51730 90022254
Malignant neoplasm progression 146.05 9.45 269 554194 106601 89967383
Night sweats 138.68 9.45 1299 553164 127467 89946517
Impaired healing 137.57 9.45 2104 552359 232095 89841889
Blood pressure increased 136.68 9.45 1824 552639 195393 89878591
Sopor 136.04 9.45 3 554460 24641 90049343
Agranulocytosis 133.35 9.45 26 554437 34976 90039008
Leukopenia 131.93 9.45 260 554203 100450 89973534
Blood pressure systolic increased 131.20 9.45 704 553759 57641 90016343
Septic shock 130.65 9.45 195 554268 83965 89990019
Drug reaction with eosinophilia and systemic symptoms 128.90 9.45 50 554413 42708 90031276
Blister 124.34 9.45 2222 552241 252776 89821208
Drug resistance 123.94 9.45 19 554444 30430 90043554
Infusion related reaction 122.53 9.45 3378 551085 413402 89660582
Hypokalaemia 121.89 9.45 403 554060 130713 89943271
Hepatic function abnormal 121.11 9.45 66 554397 46222 90027762
Temperature regulation disorder 118.28 9.45 270 554193 14309 90059675
Hyperkalaemia 113.53 9.45 138 554325 64826 90009158
Heart rate increased 113.20 9.45 1122 553341 111780 89962204
Bursitis 112.60 9.45 1267 553196 130387 89943597
Toxic anterior segment syndrome 112.07 9.45 100 554363 2150 90071834
Febrile neutropenia 110.43 9.45 545 553918 157804 89916180
Stomatitis 108.98 9.45 2320 552143 272378 89801606
Cholestasis 108.51 9.45 43 554420 36256 90037728
Coma 108.23 9.45 173 554290 72459 90001525
Hepatic cytolysis 107.68 9.45 28 554435 30888 90043096
Thrombocytopenia 107.34 9.45 791 553672 207934 89866050
Contusion 105.64 9.45 2140 552323 249076 89824908
Disease progression 104.13 9.45 548 553915 156067 89917917
Drug ineffective 103.69 9.45 7188 547275 1377110 88696874
Bone marrow failure 103.40 9.45 34 554429 32187 90041797
Device expulsion 103.09 9.45 61 554402 40825 90033159
Rhabdomyolysis 101.64 9.45 98 554365 51158 90022826
Hepatocellular injury 101.29 9.45 26 554437 28932 90045052
Urticaria 100.27 9.45 2564 551899 310170 89763814
Respiratory disorder 99.03 9.45 708 553755 64108 90009876
Mucosal inflammation 99.03 9.45 124 554339 57501 90016483
Pruritus 98.43 9.45 4150 550313 537375 89536609
Cytomegalovirus infection 96.74 9.45 22 554441 26580 90047404
Joint swelling 95.55 9.45 3875 550588 499425 89574559
Intentional self-injury 94.05 9.45 31 554432 29303 90044681
Macular degeneration 93.85 9.45 58 554405 37912 90036072
Sinus disorder 92.49 9.45 437 554026 34010 90039974
Sleep disorder due to general medical condition, insomnia type 92.35 9.45 1198 553265 127496 89946488
Hypocalcaemia 89.99 9.45 76 554387 42292 90031692
Suicide attempt 89.28 9.45 206 554257 75193 89998791
Gamma-glutamyltransferase increased 88.35 9.45 62 554401 37890 90036094
Infection 88.03 9.45 2867 551596 359227 89714757
Lactic acidosis 87.33 9.45 108 554355 50355 90023629
General physical health deterioration 87.15 9.45 1588 552875 353527 89720457
Toxic epidermal necrolysis 85.65 9.45 46 554417 32482 90041502
Osteonecrosis of jaw 83.23 9.45 70 554393 39033 90034951
Oxygen saturation decreased 82.85 9.45 1014 553449 106469 89967515
Fatigue 81.60 9.45 8153 546310 1145870 88928114
Insomnia 81.20 9.45 2641 551822 330833 89743151
Hypoglycaemia 80.97 9.45 193 554270 69655 90004329
Renal impairment 78.68 9.45 354 554109 105067 89968917
Coeliac disease 76.29 9.45 501 553962 44109 90029875
Intentional overdose 75.61 9.45 306 554157 93528 89980456
Multiple organ dysfunction syndrome 73.64 9.45 196 554267 68140 90005844
Interstitial lung disease 72.97 9.45 232 554231 76173 89997811
Pain 72.67 9.45 7055 547408 989286 89084698
Chest discomfort 72.16 9.45 1219 553244 137146 89936838
Aspartate aminotransferase increased 71.91 9.45 354 554109 102583 89971401
Illness 71.50 9.45 792 553671 81177 89992807
Alanine aminotransferase increased 70.04 9.45 430 554033 117908 89956076
Electrocardiogram QT prolonged 68.50 9.45 221 554242 72235 90001749
Angioedema 66.24 9.45 191 554272 64685 90009299
Cardio-respiratory arrest 65.86 9.45 184 554279 62956 90011028
Rhinorrhoea 65.40 9.45 827 553636 87489 89986495
Condition aggravated 65.06 9.45 2979 551484 592566 89481418
Abortion spontaneous 64.55 9.45 147 554316 53909 90020075
Fluid retention 64.01 9.45 822 553641 87269 89986715
Pneumocystis jirovecii pneumonia 63.97 9.45 26 554437 21590 90052394
Gangrene 63.28 9.45 198 554265 12678 90061306
Anxiety 63.13 9.45 2404 552059 307368 89766616
Heart rate decreased 62.27 9.45 549 553914 52956 90021028
Blood parathyroid hormone decreased 62.10 9.45 3 554460 12213 90061771
Immunodeficiency 61.88 9.45 465 553998 42769 90031215
Neck pain 60.88 9.45 1008 553455 112955 89961029
Pancreatitis acute 60.71 9.45 64 554399 32051 90041933
Infusion site erythema 60.66 9.45 203 554260 13467 90060517
Migraine 60.38 9.45 1559 552904 188833 89885151
Sensory loss 59.70 9.45 244 554219 17831 90056153
Infusion site pruritus 59.05 9.45 129 554334 6636 90067348
Drug eruption 57.95 9.45 79 554384 35328 90038656
Poisoning 56.52 9.45 12 554451 15205 90058779
Stevens-Johnson syndrome 56.14 9.45 58 554405 29318 90044666
Arterial occlusive disease 55.38 9.45 185 554278 12261 90061723
Rheumatoid arthritis 54.72 9.45 2728 551735 359886 89714098
Bronchial secretion retention 54.27 9.45 87 554376 3528 90070456
Lymphopenia 53.76 9.45 37 554426 22844 90051140
Melaena 53.63 9.45 81 554382 34716 90039268
Thrombotic microangiopathy 53.43 9.45 15 554448 15728 90058256
Hyperglycaemia 52.82 9.45 149 554314 50821 90023163
Oropharyngeal pain 52.67 9.45 994 553469 114193 89959791
Upper respiratory tract infection 52.20 9.45 1088 553375 127230 89946754
Hypersensitivity 52.16 9.45 3336 551127 451341 89622643
Infusion site swelling 51.97 9.45 174 554289 11546 90062438
Tubulointerstitial nephritis 51.96 9.45 47 554416 25296 90048688
Blood pressure diastolic increased 51.48 9.45 185 554278 12721 90061263
Blood pressure diastolic decreased 51.29 9.45 310 554153 26516 90047468
Personality disorder 51.03 9.45 180 554283 12264 90061720
Proctitis 50.94 9.45 15 554448 15244 90058740
Kounis syndrome 50.62 9.45 70 554393 2483 90071501
Panniculitis 50.53 9.45 13 554450 14445 90059539
Scoliosis 50.43 9.45 144 554319 8763 90065221
Neurologic neglect syndrome 50.06 9.45 143 554320 8704 90065280
Depressed level of consciousness 49.86 9.45 252 554211 72532 90001452
Sinus congestion 49.35 9.45 312 554151 27112 90046872
Pain in extremity 49.06 9.45 3291 551172 447238 89626746
Sneezing 48.99 9.45 332 554131 29537 90044447
Renal failure 48.70 9.45 539 553924 130468 89943516
Poisoning deliberate 48.51 9.45 20 554443 16466 90057518
Transaminases increased 47.85 9.45 97 554366 37095 90036889
Finger deformity 47.75 9.45 355 554108 32542 90041442
Carotid artery thrombosis 47.66 9.45 143 554320 8949 90065035
Altered state of consciousness 47.07 9.45 75 554388 31457 90042527
Confusional state 46.93 9.45 2848 551615 383357 89690627
Toxic skin eruption 46.63 9.45 19 554444 15755 90058229
Suspected suicide 46.63 9.45 3 554460 9565 90064419
Metabolic acidosis 46.48 9.45 179 554284 55497 90018487
Nasal congestion 46.11 9.45 742 553721 82672 89991312
Hypercalcaemia 46.05 9.45 87 554376 34153 90039831
Infusion site pain 45.62 9.45 240 554223 19498 90054486
Inappropriate antidiuretic hormone secretion 45.22 9.45 32 554431 19473 90054511
Respiratory tract congestion 45.15 9.45 305 554158 27105 90046879
Granuloma skin 45.02 9.45 6 554457 10674 90063310
Arthralgia 44.81 9.45 5428 549035 773094 89300890
Orthostatic hypotension 44.29 9.45 121 554342 41706 90032278
Back injury 44.15 9.45 458 554005 46164 90027820
Acute respiratory distress syndrome 43.99 9.45 67 554396 28619 90045365
Bacterial disease carrier 42.90 9.45 55 554408 1811 90072173
Anterior spinal artery syndrome 42.89 9.45 22 554441 177 90073807
Adjustment disorder 42.62 9.45 143 554320 9499 90064485
Jaundice 42.53 9.45 84 554379 32433 90041551
Alopecia 42.51 9.45 2537 551926 492534 89581450
Seasonal allergy 42.31 9.45 263 554200 22720 90051264
C-reactive protein increased 42.01 9.45 819 553644 180570 89893414
Haemophagocytic lymphohistiocytosis 41.98 9.45 21 554442 15438 90058546
Neuroleptic malignant syndrome 41.76 9.45 20 554443 15076 90058908
Transplant rejection 41.76 9.45 13 554450 12745 90061239
Pleural fibrosis 41.47 9.45 77 554386 3519 90070465
Blood creatinine increased 41.41 9.45 408 554055 100978 89973006
Presbyacusis 41.35 9.45 70 554393 2972 90071012
Foetal exposure during pregnancy 40.67 9.45 131 554332 42844 90031140
Rheumatoid nodule 40.63 9.45 38 554425 20128 90053856
Bronchopulmonary aspergillosis 40.32 9.45 10 554453 11388 90062596
Death 40.19 9.45 2334 552129 454217 89619767
Asthma 39.92 9.45 1838 552625 240322 89833662
Polyneuropathy 39.50 9.45 36 554427 19305 90054679
Diabetic ketoacidosis 39.40 9.45 55 554408 24352 90049632
Rash maculo-papular 39.28 9.45 124 554339 40809 90033175
Musculoskeletal pain 39.26 9.45 1347 553116 169904 89904080
Serotonin syndrome 39.08 9.45 111 554352 37776 90036208
Colitis microscopic 39.07 9.45 10 554453 11149 90062835
Methaemoglobinaemia 39.03 9.45 80 554383 3935 90070049
Infusion site extravasation 38.64 9.45 145 554318 10183 90063801
Sleep disorder 38.46 9.45 1529 552934 196501 89877483
Product prescribing error 38.46 9.45 79 554384 30066 90043918
Radiculopathy 38.32 9.45 34 554429 18471 90055513
Sinus operation 38.26 9.45 67 554396 2924 90071060
Hepatitis cholestatic 38.09 9.45 4 554459 8557 90065427
Pleural thickening 38.02 9.45 70 554393 3178 90070806
Anaesthetic complication 37.94 9.45 60 554403 2405 90071579
Cough 37.65 9.45 2681 551782 366281 89707703
Syncope 37.47 9.45 578 553885 132085 89941899
Posterior reversible encephalopathy syndrome 37.42 9.45 49 554414 22290 90051694
Neovascularisation 37.40 9.45 48 554415 1582 90072402
Rheumatoid factor positive 37.36 9.45 783 553680 170867 89903117
Metastases to liver 37.17 9.45 75 554388 28732 90045252
Injection site pain 37.03 9.45 795 553668 172904 89901080
Throat irritation 36.91 9.45 458 554005 48237 90025747
Blood magnesium increased 36.85 9.45 71 554392 3337 90070647
Subcutaneous drug absorption impaired 36.48 9.45 172 554291 13373 90060611
Abdominal pain upper 36.33 9.45 2431 552032 330243 89743741
Drug-induced liver injury 36.24 9.45 365 554098 89953 89984031
Postnatal growth restriction 36.12 9.45 15 554448 69 90073915
Aplastic anaemia 36.07 9.45 18 554445 13251 90060733
Corneal oedema 36.02 9.45 51 554412 1850 90072134
Graft versus host disease 35.74 9.45 4 554459 8140 90065844
Red blood cell sedimentation rate abnormal 35.72 9.45 58 554405 24146 90049838
Peritonitis 35.34 9.45 41 554422 19664 90054320
Back disorder 35.18 9.45 273 554190 25358 90048626
Platelet count decreased 34.97 9.45 608 553855 136361 89937623
Gastrointestinal haemorrhage 34.87 9.45 368 554095 89880 89984104
Respiratory arrest 34.79 9.45 97 554366 33214 90040770
Hypomagnesaemia 34.72 9.45 107 554356 35481 90038503
Helicobacter infection 34.67 9.45 1709 552754 225141 89848843
Dyspnoea 34.64 9.45 6009 548454 874946 89199038
Neutropenic sepsis 34.41 9.45 36 554427 18094 90055890
Anaphylactic reaction 34.26 9.45 738 553725 86786 89987198
Influenza like illness 33.93 9.45 687 553776 79924 89994060
Therapeutic product effect decreased 33.90 9.45 2048 552415 275523 89798461
Therapeutic response decreased 33.81 9.45 368 554095 89361 89984623
Liver function test abnormal 33.72 9.45 178 554285 50667 90023317
Ascites 33.44 9.45 164 554299 47576 90026408
Respiratory failure 33.42 9.45 516 553947 117902 89956082
Vaginal discharge 33.32 9.45 42 554421 19422 90054562
Prescribed overdose 32.88 9.45 806 553657 96819 89977165
Product label confusion 32.83 9.45 246 554217 22604 90051380
Peripheral venous disease 32.65 9.45 707 553756 83214 89990770
Proteinuria 32.37 9.45 58 554405 23233 90050751
International normalised ratio increased 32.31 9.45 164 554299 47152 90026832
Cerebral infarction 32.02 9.45 72 554391 26524 90047460
Taste disorder 31.99 9.45 542 553921 61004 90012980
Sedation 31.74 9.45 169 554294 48002 90025982
Bronchospasm 31.50 9.45 226 554237 20483 90053501
Pneumonia aspiration 31.43 9.45 136 554327 40804 90033180
Adrenal insufficiency 31.35 9.45 87 554376 29834 90044150
Colitis 31.34 9.45 275 554188 69667 90004317
Agitation 31.33 9.45 261 554202 66837 90007147
Multiple-drug resistance 31.31 9.45 5 554458 7771 90066213
Flushing 31.14 9.45 735 553728 87756 89986228
Rhythm idioventricular 31.03 9.45 23 554440 376 90073608
Spinal cord injury 30.86 9.45 36 554427 1073 90072911
Gastrooesophageal reflux disease 30.84 9.45 1278 553185 165059 89908925
Influenza 30.57 9.45 1090 553373 138174 89935810
Nephropathy toxic 30.51 9.45 20 554443 12668 90061316
Motor dysfunction 30.50 9.45 212 554251 19018 90054966
Hepatic failure 30.48 9.45 132 554331 39596 90034388
Palmar-plantar erythrodysaesthesia syndrome 30.47 9.45 80 554383 27943 90046041
Infusion site haemorrhage 30.17 9.45 87 554376 5324 90068660
Device adhesion issue 30.10 9.45 3 554460 6688 90067296
Shock haemorrhagic 29.85 9.45 19 554444 12226 90061758
Off label use 29.82 9.45 6123 548340 1096129 88977855
Skin necrosis 29.58 9.45 36 554427 16905 90057079
Dermatitis bullous 29.58 9.45 13 554450 10303 90063681
Haematochezia 29.53 9.45 284 554179 70629 90003355
Rash erythematous 29.47 9.45 561 553902 64543 90009441
Haematoma 29.20 9.45 131 554332 38917 90035067
Myoclonus 29.17 9.45 45 554418 19123 90054861
Urine leukocyte esterase positive 29.12 9.45 63 554400 3219 90070765
Myelodysplastic syndrome 29.10 9.45 52 554411 20851 90053133
Psychotic disorder 29.00 9.45 96 554367 31134 90042850
Breast cancer stage II 28.82 9.45 337 554126 34997 90038987
Sepsis 28.40 9.45 860 553603 178954 89895030
Hypertransaminasaemia 28.30 9.45 33 554430 15792 90058192
Injection site erythema 28.21 9.45 428 554035 98074 89975910
Acute myeloid leukaemia 28.15 9.45 52 554411 20588 90053396
Polyarthritis 28.00 9.45 43 554420 18307 90055677
Akathisia 27.64 9.45 17 554446 11142 90062842
Urine abnormality 27.61 9.45 107 554356 7630 90066354
Wrong technique in product usage process 27.58 9.45 292 554171 71279 90002705
Acute generalised exanthematous pustulosis 27.40 9.45 26 554437 13677 90060307
Blood creatine phosphokinase increased 27.37 9.45 111 554352 33912 90040072
Deafness neurosensory 27.24 9.45 98 554365 6743 90067241
Peptic ulcer haemorrhage 27.22 9.45 34 554429 1090 90072894
Ulcer haemorrhage 27.06 9.45 263 554200 26058 90047926
Pathogen resistance 27.05 9.45 8 554455 8107 90065877
Seizure 26.89 9.45 719 553744 151910 89922074
Asthenia 26.63 9.45 3690 550773 530061 89543923
Seronegative arthritis 26.63 9.45 44 554419 18190 90055794
Parkinsonism 26.62 9.45 28 554435 14037 90059947
Anaphylactic shock 26.43 9.45 303 554160 31314 90042670
Weight fluctuation 26.36 9.45 209 554254 19540 90054444
Cerebral haemorrhage 26.31 9.45 115 554348 34407 90039577
Incorrect drug administration rate 26.30 9.45 81 554382 5142 90068842
Systemic toxicity 26.29 9.45 18 554445 258 90073726
Affect lability 26.26 9.45 195 554268 17868 90056116
Skin haemorrhage 26.25 9.45 222 554241 21158 90052826
Femoral neck fracture 26.18 9.45 15 554448 10218 90063766
Cytomegalovirus viraemia 26.17 9.45 7 554456 7579 90066405
Peripheral sensory neuropathy 25.98 9.45 12 554451 9238 90064746
Product tampering 25.93 9.45 22 554441 441 90073543
Insurance issue 25.85 9.45 134 554329 10824 90063160
Product quality issue 25.84 9.45 652 553811 78673 89995311
Nail disorder 25.73 9.45 506 553957 58561 90015423
Anaesthetic complication neurological 25.71 9.45 27 554436 714 90073270
Wound infection 25.67 9.45 842 553621 105560 89968424
Epigastric discomfort 25.66 9.45 103 554360 7465 90066519
Haematemesis 25.30 9.45 113 554350 33613 90040371
Dyskinesia 25.30 9.45 126 554337 36408 90037576
Disorientation 25.21 9.45 162 554301 43952 90030032
Bone cyst 25.05 9.45 49 554414 2329 90071655
Hyperbilirubinaemia 24.99 9.45 29 554434 13907 90060077
Nephrotic syndrome 24.89 9.45 7 554456 7332 90066652
Gait inability 24.86 9.45 1115 553348 145341 89928643
Aspergillus infection 24.77 9.45 18 554445 10805 90063179
Procedural hypotension 24.70 9.45 39 554424 1561 90072423
Mania 24.68 9.45 30 554433 14094 90059890
Hypothyroidism 24.64 9.45 207 554256 52920 90021064
Progressive multifocal leukoencephalopathy 24.55 9.45 36 554427 15619 90058365
Superinfection 24.54 9.45 57 554406 3055 90070929
Adverse reaction 24.51 9.45 284 554179 29428 90044556
Hyperthyroidism 24.20 9.45 47 554416 18263 90055721
Hepatic enzyme increased 24.19 9.45 2541 551922 358195 89715789
Osteonecrosis 24.14 9.45 81 554382 26160 90047824
Infusion site urticaria 24.02 9.45 40 554423 1675 90072309
Epstein-Barr virus infection 23.94 9.45 17 554446 10327 90063657
Skin toxicity 23.88 9.45 6 554457 6773 90067211
Sudden death 23.87 9.45 19 554444 10890 90063094
Torsade de pointes 23.73 9.45 35 554428 15147 90058837
Hallucination, visual 23.56 9.45 68 554395 23024 90050960
Ischaemic stroke 23.56 9.45 64 554399 22102 90051882
Productive cough 23.53 9.45 628 553835 76435 89997549
Joint destruction 23.45 9.45 28 554435 13259 90060725
Drug dependence 23.39 9.45 96 554367 29231 90044753
Emotional distress 23.30 9.45 334 554129 36328 90037656
Metastases to bone 23.27 9.45 79 554384 25426 90048558
Foetal death 23.27 9.45 211 554252 20512 90053472
Neutrophil count decreased 23.25 9.45 303 554160 71229 90002755
Hemiplegia 23.23 9.45 174 554289 15986 90057998
Suicidal ideation 23.22 9.45 315 554148 73540 90000444
Infusion site bruising 23.14 9.45 69 554394 4303 90069681
Ventilation perfusion mismatch 23.14 9.45 23 554440 569 90073415
Systemic lupus erythematosus 23.04 9.45 1903 552560 359993 89713991
Concussion 23.03 9.45 131 554332 10960 90063024
Infusion site reaction 23.01 9.45 197 554266 18842 90055142
Hyperhidrosis 22.97 9.45 1037 553426 135268 89938716
Diabetes mellitus inadequate control 22.97 9.45 50 554413 18634 90055350
Joint dislocation 22.87 9.45 169 554294 44413 90029571
Euglycaemic diabetic ketoacidosis 22.81 9.45 5 554458 6196 90067788
Breast cancer female 22.60 9.45 35 554428 14851 90059133
Rash vesicular 22.36 9.45 189 554274 18008 90055976
Cognitive disorder 22.19 9.45 295 554168 69112 90004872
Metastases to lung 22.06 9.45 40 554423 15951 90058033
Cataract 21.87 9.45 587 553876 71505 90002479
Swollen tongue 21.80 9.45 178 554285 45778 90028206
Stress 21.44 9.45 651 553812 80744 89993240
Sulphaemoglobinaemia 21.37 9.45 21 554442 512 90073472
Dermatitis exfoliative 21.33 9.45 4 554459 5532 90068452
Blood lactate dehydrogenase increased 21.24 9.45 84 554379 25848 90048136
Multiple allergies 21.17 9.45 162 554301 14984 90059000
General symptom 21.12 9.45 158 554305 14510 90059474
Accidental exposure to product 21.07 9.45 162 554301 42204 90031780
Rib fracture 21.06 9.45 251 554212 26184 90047800
Drug tolerance decreased 21.02 9.45 113 554350 32017 90041967
Foetal growth restriction 20.95 9.45 16 554447 9364 90064620
Osteoarthritis 20.94 9.45 1428 553035 194302 89879682
Enterocolitis 20.86 9.45 20 554443 10470 90063514
Gestational hypertension 20.85 9.45 53 554410 3009 90070975
Neuralgia 20.83 9.45 289 554174 31211 90042773
Breast cancer stage I 20.76 9.45 17 554446 9607 90064377
Muscle spasms 20.70 9.45 1800 552663 250083 89823901
Adulterated product 20.60 9.45 18 554445 376 90073608
Hypothermia 20.57 9.45 40 554423 15535 90058449
Incorrect route of product administration 20.49 9.45 429 554034 50197 90023787
Tooth disorder 20.46 9.45 285 554178 30805 90043179
Limb injury 20.40 9.45 288 554175 31220 90042764
Drug use disorder 20.26 9.45 13 554450 8330 90065654
Tumour lysis syndrome 20.22 9.45 23 554440 11129 90062855
Red blood cells urine positive 20.10 9.45 54 554409 3171 90070813
COVID-19 20.08 9.45 1243 553220 167600 89906384
Salpingo-oophorectomy unilateral 19.89 9.45 27 554436 941 90073043
Personality change 19.80 9.45 10 554453 7311 90066673
Pneumocephalus 19.79 9.45 15 554448 254 90073730
SARS-CoV-2 test positive 19.65 9.45 126 554337 11002 90062982
Pneumonitis 19.64 9.45 174 554289 43996 90029988
Erysipelas 19.52 9.45 16 554447 9036 90064948
Osteopenia 19.48 9.45 221 554242 22781 90051203
Pemphigoid 19.40 9.45 16 554447 9010 90064974
Abnormal behaviour 19.37 9.45 72 554391 22556 90051428
Spinal meningioma benign 19.34 9.45 11 554452 111 90073873
Genital haemorrhage 19.24 9.45 15 554448 8687 90065297
Eating disorder 19.15 9.45 259 554204 27814 90046170
Atelectasis 19.11 9.45 231 554232 24178 90049806
Haemoglobin decreased 19.08 9.45 803 553660 161153 89912831
Chills 19.06 9.45 989 553474 130992 89942992
Skin ulcer 19.01 9.45 205 554258 49870 90024114
Acute graft versus host disease 18.95 9.45 5 554458 5463 90068521
Cytopenia 18.83 9.45 50 554413 17399 90056585
Asphyxia 18.77 9.45 10 554453 7093 90066891
Female genital tract fistula 18.68 9.45 52 554411 17816 90056168
Femur fracture 18.58 9.45 186 554277 45896 90028088
Poor venous access 18.57 9.45 192 554271 19335 90054649
Live birth 18.56 9.45 624 553839 78483 89995501
Administration site pain 18.38 9.45 29 554434 1160 90072824
Pineal gland cyst 18.37 9.45 13 554450 197 90073787
Hypoalbuminaemia 18.36 9.45 44 554419 15853 90058131
Mixed liver injury 18.35 9.45 12 554451 7611 90066373
Blood folate decreased 18.31 9.45 35 554428 1635 90072349
Cervicogenic headache 18.26 9.45 13 554450 199 90073785
Blood alkaline phosphatase increased 18.18 9.45 197 554266 47882 90026102
Carbuncle 18.15 9.45 32 554431 1404 90072580
Intentional product use issue 17.98 9.45 1551 552912 215341 89858643
Hallucination, auditory 17.84 9.45 45 554418 15930 90058054
Abdominal pain 17.80 9.45 2134 552329 393587 89680397
Cestode infection 17.75 9.45 15 554448 299 90073685
Product substitution issue 17.67 9.45 54 554409 17954 90056030
Metastases to central nervous system 17.65 9.45 52 554411 17490 90056494
Anhedonia 17.53 9.45 125 554338 11306 90062678
Cardiovascular disorder 17.52 9.45 35 554428 13457 90060527
X-ray abnormal 17.45 9.45 382 554081 45042 90028942
Anterior chamber cell 17.40 9.45 22 554441 714 90073270
Basal cell carcinoma 17.40 9.45 126 554337 33263 90040721
Lupus vasculitis 17.36 9.45 20 554443 588 90073396
Pleural effusion 17.34 9.45 537 553926 111454 89962530
Ulcer 17.18 9.45 124 554339 32758 90041226
Cystitis 17.14 9.45 532 553931 66186 90007798
Second primary malignancy 17.14 9.45 23 554440 10355 90063629
Coordination abnormal 17.11 9.45 203 554260 21153 90052831
Cardiac failure congestive 17.10 9.45 466 553997 98228 89975756
Unintentional medical device removal 17.01 9.45 11 554452 7019 90066965
Ileus paralytic 16.97 9.45 5 554458 5080 90068904
Cytokine release syndrome 16.88 9.45 101 554362 27872 90046112
Body height decreased 16.81 9.45 128 554335 11821 90062163
Blood urea increased 16.72 9.45 113 554350 30300 90043684
Upper gastrointestinal haemorrhage 16.63 9.45 78 554385 22898 90051086
Large intestine perforation 16.58 9.45 21 554442 9691 90064293
Sinus headache 16.55 9.45 81 554382 6395 90067589
Allergy to immunoglobulin therapy 16.46 9.45 12 554451 191 90073793
Duodenal ulcer perforation 16.45 9.45 1570 552893 219718 89854266
Obstruction 16.32 9.45 57 554406 3864 90070120
Haematuria 16.26 9.45 136 554327 34801 90039183
Disseminated intravascular coagulation 16.26 9.45 72 554391 21466 90052518
Blepharospasm 16.12 9.45 449 554014 54996 90018988
Enteritis 15.93 9.45 24 554439 10297 90063687
Lip dry 15.92 9.45 763 553700 100192 89973792
Ear pruritus 15.91 9.45 83 554380 6720 90067264
Rectal haemorrhage 15.85 9.45 385 554078 82359 89991625
Mouth ulceration 15.84 9.45 162 554301 39812 90034172
Cyst 15.83 9.45 163 554300 16398 90057586
Face oedema 15.82 9.45 81 554382 23237 90050747
Bradyphrenia 15.74 9.45 14 554449 7598 90066386
Pulmonary tuberculosis 15.69 9.45 5 554458 4829 90069155
Pulmonary embolism 15.54 9.45 648 553815 130172 89943812
Exposure during pregnancy 15.50 9.45 1676 552787 236734 89837250
Tardive dyskinesia 15.38 9.45 27 554436 10903 90063081
Gastroenteritis 15.38 9.45 110 554353 29119 90044865
Encephalitis 15.23 9.45 28 554435 11106 90062878
Infusion site nodule 15.20 9.45 33 554430 1690 90072294
Extradural abscess 15.13 9.45 28 554435 1276 90072708
Pancreatitis 15.04 9.45 319 554144 69507 90004477
Stillbirth 15.03 9.45 14 554449 7429 90066555
Stress cardiomyopathy 15.01 9.45 136 554327 13219 90060765
Libido increased 14.93 9.45 33 554430 1711 90072273
Blood bilirubin increased 14.92 9.45 182 554281 43288 90030696
Lactose intolerance 14.92 9.45 50 554413 3319 90070665
Incision site swelling 14.90 9.45 13 554450 271 90073713
Infusion site rash 14.90 9.45 41 554422 2442 90071542
Hepatitis fulminant 14.88 9.45 3 554460 3942 90070042
Injection site swelling 14.83 9.45 267 554196 59572 90014412
Gastrointestinal toxicity 14.80 9.45 104 554359 9363 90064621
Dystonia 14.74 9.45 53 554410 16766 90057218
Muscle rigidity 14.70 9.45 42 554421 14267 90059717
Drug dose omission by device 14.65 9.45 25 554438 10206 90063778
Post-traumatic neck syndrome 14.58 9.45 41 554422 2473 90071511
Myocarditis 14.57 9.45 40 554423 13766 90060218
Meningitis chemical 14.55 9.45 13 554450 280 90073704
Hallucinations, mixed 14.55 9.45 9 554454 5880 90068104
White blood cell count increased 14.54 9.45 307 554156 66934 90007050
Diffuse large B-cell lymphoma 14.44 9.45 19 554444 8626 90065358
Infusion site discharge 14.41 9.45 40 554423 2395 90071589
Graft versus host disease in skin 14.39 9.45 3 554460 3850 90070134
Oedema peripheral 14.38 9.45 1370 553093 256545 89817439
Pyrexia 14.37 9.45 4385 550078 656100 89417884
Lip pruritus 14.30 9.45 28 554435 1332 90072652
Clostridium difficile colitis 14.30 9.45 100 554363 26606 90047378
Lagophthalmos 14.28 9.45 16 554447 456 90073528
Pustular psoriasis 14.26 9.45 175 554288 18381 90055603
Neoplasm progression 14.25 9.45 189 554274 44297 90029687
Spinal epidural haemorrhage 14.25 9.45 13 554450 288 90073696
Fracture 14.24 9.45 78 554385 21998 90051986
Cystitis haemorrhagic 14.22 9.45 8 554455 5505 90068479
Joint range of motion decreased 14.22 9.45 988 553475 134655 89939329
Hypoaesthesia oral 14.18 9.45 152 554311 15448 90058536
Metamorphopsia 14.13 9.45 29 554434 1428 90072556
Specific gravity urine increased 14.08 9.45 12 554451 242 90073742
Red blood cell sedimentation rate increased 14.05 9.45 391 554072 82204 89991780
Infusion site discomfort 14.04 9.45 33 554430 1783 90072201
Soft tissue injury 14.03 9.45 36 554427 2056 90071928
Device dislocation 14.01 9.45 124 554339 31358 90042626
Bacterial test 14.00 9.45 25 554438 1108 90072876
Injection site haematoma 14.00 9.45 13 554450 6909 90067075
Infusion site mass 13.99 9.45 37 554426 2152 90071832
BK virus infection 13.99 9.45 5 554458 4493 90069491
Ileus 13.94 9.45 53 554410 16493 90057491
Sinus rhythm 13.93 9.45 28 554435 1358 90072626
Blue toe syndrome 13.90 9.45 16 554447 470 90073514
Dyschromatopsia 13.89 9.45 20 554443 737 90073247
Premature baby 13.87 9.45 93 554370 24984 90049000
Drug withdrawal syndrome 13.74 9.45 111 554352 28612 90045372
Hypopyon 13.73 9.45 22 554441 892 90073092
Lung disorder 13.73 9.45 1080 553383 148803 89925181
Hypotonia 13.70 9.45 31 554432 11395 90062589
Cardiotoxicity 13.57 9.45 31 554432 11358 90062626
Pulse absent 13.57 9.45 73 554390 5982 90068002
Congestive cardiomyopathy 13.52 9.45 15 554448 7339 90066645
Injury 13.48 9.45 1392 553071 195957 89878027
Drug tolerance 13.46 9.45 60 554403 17856 90056128
Pemphigus 13.42 9.45 1773 552690 325091 89748893
Flail chest 13.40 9.45 8 554455 89 90073895
Glossodynia 13.38 9.45 1744 552719 320035 89753949
Feeling hot 13.25 9.45 594 553869 77414 89996570
Salivary hypersecretion 13.22 9.45 22 554441 9070 90064914
Dermatitis exfoliative generalised 13.20 9.45 9 554454 5584 90068400
Dissociation 13.13 9.45 13 554450 6702 90067282
Sputum culture 13.10 9.45 13 554450 321 90073663
Premature rupture of membranes 13.04 9.45 9 554454 5549 90068435
Poor quality sleep 13.03 9.45 218 554245 24475 90049509
Hepatic encephalopathy 13.02 9.45 42 554421 13730 90060254
White blood cells urine positive 13.00 9.45 76 554387 6422 90067562
Adenovirus infection 12.98 9.45 6 554457 4616 90069368
Injection site reaction 12.95 9.45 447 554016 91633 89982351
Subacute cutaneous lupus erythematosus 12.95 9.45 3 554460 3579 90070405
Lung perforation 12.89 9.45 8 554455 96 90073888
Abortion induced 12.88 9.45 34 554429 11854 90062130
Magnesium deficiency 12.84 9.45 19 554444 718 90073266
Exposure to toxic agent 12.81 9.45 18 554445 7949 90066035
Peripheral nerve injury 12.80 9.45 19 554444 720 90073264
Platelet aggregation inhibition 12.73 9.45 10 554453 179 90073805
Vein collapse 12.69 9.45 24 554439 1112 90072872
Leukoencephalopathy 12.67 9.45 7 554456 4866 90069118
Loss of consciousness 12.65 9.45 715 553748 139523 89934461
Swelling 12.65 9.45 2822 551641 416236 89657748
Dermatitis contact 12.61 9.45 133 554330 13462 90060522
Therapy interrupted 12.60 9.45 223 554240 49885 90024099
Kidney transplant rejection 12.60 9.45 7 554456 4850 90069134
Hepatitis B 12.48 9.45 6 554457 4513 90069471
Staphylococcal sepsis 12.48 9.45 24 554439 9359 90064625
Purtscher retinopathy 12.47 9.45 9 554454 141 90073843
Hypovolaemic shock 12.47 9.45 15 554448 7079 90066905
Loss of personal independence in daily activities 12.45 9.45 693 553770 135412 89938572
Disease recurrence 12.42 9.45 159 554304 37494 90036490
Mycobacterial disease carrier 12.40 9.45 5 554458 21 90073963
Nerve root injury 12.36 9.45 7 554456 70 90073914
Joint injury 12.32 9.45 274 554189 32390 90041594
Eyelid rash 12.30 9.45 14 554449 406 90073578
Klebsiella infection 12.29 9.45 28 554435 10269 90063715
Psychomotor retardation 12.28 9.45 7 554456 4782 90069202
Urinary sediment present 12.17 9.45 35 554428 2139 90071845
Hyperammonaemia 12.13 9.45 13 554450 6462 90067522
Procedural pain 12.10 9.45 138 554325 33222 90040762
Partial seizures 12.08 9.45 16 554447 7244 90066740
Nerve compression 12.08 9.45 108 554355 10458 90063526
Red cell distribution width increased 12.07 9.45 121 554342 12086 90061898
Atonic urinary bladder 12.05 9.45 9 554454 149 90073835
Arteriovenous fistula occlusion 11.96 9.45 13 554450 358 90073626
Trigeminal palsy 11.95 9.45 7 554456 75 90073909
Faecaloma 11.95 9.45 29 554434 10402 90063582
Tryptase increased 11.93 9.45 16 554447 551 90073433
Hepatitis acute 11.90 9.45 31 554432 10856 90063128
Small for dates baby 11.89 9.45 8 554455 4999 90068985
Vital capacity decreased 11.89 9.45 31 554432 1788 90072196
Graft versus host disease in gastrointestinal tract 11.86 9.45 6 554457 4382 90069602
Foot deformity 11.85 9.45 276 554187 59375 90014609
Calcification of muscle 11.85 9.45 10 554453 199 90073785
Dry mouth 11.83 9.45 1293 553170 182766 89891218
Treatment noncompliance 11.83 9.45 234 554229 51493 90022491
Cutaneous vasculitis 11.82 9.45 16 554447 7177 90066807
Oliguria 11.80 9.45 30 554433 10594 90063390
Cholangitis 11.78 9.45 16 554447 7166 90066818
Arrhythmia 11.75 9.45 185 554278 42147 90031837
Migraine with aura 11.75 9.45 45 554418 3191 90070793
Urine analysis abnormal 11.73 9.45 63 554400 5158 90068826
Device related infection 11.72 9.45 101 554362 25685 90048299
Monoclonal immunoglobulin present 11.70 9.45 34 554429 2090 90071894
Hand-foot-and-mouth disease 11.70 9.45 15 554448 494 90073490
Maternal exposure timing unspecified 11.68 9.45 198 554265 22285 90051699
Palpitations 11.68 9.45 980 553483 135748 89938236
Bladder spasm 11.67 9.45 33 554430 1997 90071987
Aqueous fibrin 11.66 9.45 8 554455 115 90073869
Dry eye 11.63 9.45 449 554014 57482 90016502
Oral candidiasis 11.59 9.45 150 554313 35305 90038679
Injection site pruritus 11.58 9.45 246 554217 53588 90020396
Circulatory collapse 11.57 9.45 97 554366 24807 90049177
Demyelination 11.56 9.45 20 554443 8120 90065864
Metastases to lymph nodes 11.51 9.45 35 554428 11654 90062330
Type IIa hyperlipidaemia 11.47 9.45 12 554451 316 90073668
Disseminated tuberculosis 11.47 9.45 3 554460 3296 90070688
Paraesthesia oral 11.46 9.45 131 554332 31528 90042456
Labelled drug-drug interaction medication error 11.46 9.45 48 554415 14534 90059450
Duodenal ulcer 11.38 9.45 26 554437 9526 90064458
Tuberculosis 11.36 9.45 39 554424 12510 90061474
Restlessness 11.35 9.45 152 554311 35568 90038416
Throat tightness 11.34 9.45 248 554215 29236 90044748
Escherichia bacteraemia 11.33 9.45 11 554452 5724 90068260
Endometrial disorder 11.30 9.45 19 554444 802 90073182
Vomiting 11.29 9.45 4498 549965 783795 89290189
Lymphoproliferative disorder 11.26 9.45 6 554457 4256 90069728
Haemorrhage intracranial 11.25 9.45 51 554412 15111 90058873
Eczema 11.25 9.45 242 554221 52628 90021356
Hostility 11.21 9.45 35 554428 2238 90071746
Hypogammaglobulinaemia 11.21 9.45 31 554432 10643 90063341
Apnoea 11.16 9.45 97 554366 9317 90064667
Subarachnoid haemorrhage 11.15 9.45 64 554399 17840 90056144
Pulseless electrical activity 11.10 9.45 93 554370 8839 90065145
Hypotension 11.06 9.45 1785 552678 323612 89750372
Potentiating drug interaction 11.02 9.45 11 554452 5651 90068333
Tooth abscess 11.02 9.45 151 554312 16262 90057722
Osteosclerosis 11.01 9.45 54 554409 4266 90069718
Mite allergy 10.98 9.45 19 554444 821 90073163
Nonspecific reaction 10.98 9.45 40 554423 2769 90071215
Wheezing 10.89 9.45 1638 552825 236442 89837542
Coma scale abnormal 10.87 9.45 11 554452 5615 90068369
Sensitisation 10.85 9.45 6 554457 4169 90069815
Lower respiratory tract congestion 10.84 9.45 45 554418 3311 90070673
Atypical femur fracture 10.84 9.45 14 554449 6407 90067577
Rebound effect 10.82 9.45 26 554437 9358 90064626
Hyperpyrexia 10.79 9.45 8 554455 4753 90069231
Chronic graft versus host disease 10.68 9.45 6 554457 4133 90069851
Muscular weakness 10.68 9.45 1432 553031 205234 89868750
Myositis 10.61 9.45 207 554256 23921 90050063
Chronic kidney disease 10.61 9.45 230 554233 49961 90024023
Necrosis 10.56 9.45 15 554448 6595 90067389
Cerebrospinal fluid leakage 10.54 9.45 27 554436 1540 90072444
Enterococcal infection 10.50 9.45 29 554434 9962 90064022
Creatinine renal clearance decreased 10.50 9.45 70 554393 18829 90055155
Sputum culture positive 10.48 9.45 34 554429 2219 90071765
Antipsychotic drug level increased 10.46 9.45 5 554458 3774 90070210
Head discomfort 10.46 9.45 149 554314 16184 90057800
Systemic candida 10.40 9.45 9 554454 4950 90069034
Fear 10.39 9.45 151 554312 16471 90057513
Embolia cutis medicamentosa 10.38 9.45 16 554447 627 90073357
Pyelonephritis 10.37 9.45 82 554381 21234 90052750
Sternal fracture 10.36 9.45 40 554423 2847 90071137
Arthritis infective 10.35 9.45 84 554379 7908 90066076
Ear infection 10.30 9.45 524 553939 69251 90004733
Vasculitis 10.26 9.45 89 554374 22604 90051380
Pharyngeal disorder 10.25 9.45 36 554427 2447 90071537
Tracheal mass 10.25 9.45 3 554460 3 90073981
Creatinine urine decreased 10.23 9.45 11 554452 299 90073685
Device difficult to use 10.20 9.45 64 554399 17461 90056523
Acute myocardial infarction 10.19 9.45 151 554312 34739 90039245
Hiatus hernia strangulated 10.17 9.45 11 554452 301 90073683
Grip strength decreased 10.17 9.45 677 553786 91899 89982085
Claustrophobia 10.13 9.45 24 554439 1303 90072681
Blood iron abnormal 10.13 9.45 6 554457 4014 90069970
Injection site bruising 10.12 9.45 243 554220 52064 90021920
Epidural haemorrhage 10.12 9.45 11 554452 303 90073681
Intercepted medication error 10.08 9.45 19 554444 878 90073106
Hyperprolactinaemia 10.08 9.45 11 554452 5422 90068562
Device malfunction 10.06 9.45 81 554382 20896 90053088
Muscle strain 10.06 9.45 97 554366 9590 90064394
Spinal epidural haematoma 10.05 9.45 24 554439 1310 90072674
Oesophagitis 10.03 9.45 63 554400 17186 90056798
Respiratory symptom 10.03 9.45 52 554411 4200 90069784
Hallucination 10.03 9.45 317 554146 65642 90008342
Decreased appetite 9.98 9.45 2093 552370 374447 89699537
Oesophageal motility disorder 9.96 9.45 16 554447 650 90073334
Juvenile idiopathic arthritis 9.93 9.45 6 554457 3971 90070013
Disability assessment scale score increased 9.92 9.45 49 554414 3882 90070102
Granuloma 9.92 9.45 14 554449 6171 90067813
Thoracic operation 9.92 9.45 8 554455 149 90073835
Influenza virus test positive 9.87 9.45 8 554455 150 90073834
Hypoaesthesia 9.87 9.45 2120 552343 312090 89761894
Swollen joint count increased 9.85 9.45 568 553895 110638 89963346
Migraine without aura 9.77 9.45 17 554446 738 90073246
Medical device site abscess 9.77 9.45 9 554454 202 90073782
Flashback 9.75 9.45 11 554452 316 90073668
Sexual dysfunction 9.74 9.45 9 554454 4795 90069189
N-terminal prohormone brain natriuretic peptide increased 9.73 9.45 3 554460 2959 90071025
Pulse abnormal 9.73 9.45 41 554422 3038 90070946
Dermatitis allergic 9.71 9.45 64 554399 17263 90056721
Lichen sclerosus 9.71 9.45 24 554439 1339 90072645
Urinary casts present 9.68 9.45 7 554456 110 90073874
Dysponesis 9.67 9.45 5 554458 41 90073943
Intervertebral disc degeneration 9.67 9.45 154 554309 17120 90056864
Menstruation delayed 9.65 9.45 32 554431 2113 90071871
Limb mass 9.65 9.45 45 554418 3483 90070501
Chronic obstructive pulmonary disease 9.62 9.45 548 553915 73281 90000703
Organising pneumonia 9.61 9.45 20 554443 7577 90066407
Embolism 9.61 9.45 28 554435 9453 90064531
Trigemino-cardiac reflex 9.60 9.45 6 554457 73 90073911
Hypocholesterolaemia 9.59 9.45 70 554393 6379 90067605
Cytomegalovirus test positive 9.57 9.45 5 554458 3586 90070398
Immune-mediated enterocolitis 9.54 9.45 9 554454 4748 90069236
Abnormal cord insertion 9.53 9.45 4 554459 19 90073965
Abnormal dreams 9.52 9.45 36 554427 11221 90062763
Nasal oedema 9.51 9.45 16 554447 6568 90067416
Electrolyte imbalance 9.51 9.45 96 554367 23649 90050335
Dyspepsia 9.49 9.45 1367 553096 196793 89877191
Haemodialysis 9.49 9.45 25 554438 8722 90065262
Rash 9.47 9.45 5176 549287 790924 89283060

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Local anaesthetic systemic toxicity 314.72 10.30 163 170434 2137 42448601
Infusion related reaction 278.23 10.30 695 169902 60111 42390627
Drug interaction 267.18 10.30 410 170187 266589 42184149
Completed suicide 151.26 10.30 100 170497 96365 42354373
Acute kidney injury 146.98 10.30 866 169731 366471 42084267
Blood pressure diastolic abnormal 144.39 10.30 149 170448 5979 42444759
Pain 138.33 10.30 1543 169054 243305 42207433
Chills 132.88 10.30 734 169863 93332 42357406
Back pain 129.50 10.30 991 169606 140785 42309953
Sinusitis 129.17 10.30 450 170147 46842 42403896
Heart rate decreased 123.61 10.30 374 170223 36158 42414580
Anaphylactic reaction 119.59 10.30 410 170187 42333 42408405
Blood pressure increased 118.04 10.30 755 169842 101173 42349565
Fatigue 113.95 10.30 2407 168190 433234 42017504
Blood pressure systolic abnormal 113.60 10.30 125 170472 5403 42445335
General physical health deterioration 111.35 10.30 278 170319 150968 42299770
Interstitial lung disease 105.60 10.30 95 170502 78367 42372371
Myelosuppression 96.09 10.30 22 170575 40439 42410299
Blood pressure systolic increased 95.24 10.30 287 170310 27681 42423057
Thrombocytopenia 91.98 10.30 420 170177 189859 42260879
Methaemoglobinaemia 89.47 10.30 113 170484 5661 42445077
Emotional distress 88.81 10.30 198 170399 15895 42434843
Anaesthetic complication 83.38 10.30 59 170538 1398 42449340
Drug reaction with eosinophilia and systemic symptoms 83.32 10.30 32 170565 42043 42408695
Inspiratory capacity decreased 82.59 10.30 79 170518 2888 42447850
Arthralgia 80.52 10.30 1210 169387 204028 42246710
Agranulocytosis 78.19 10.30 14 170583 30598 42420140
Toxic anterior segment syndrome 77.95 10.30 56 170541 1360 42449378
Anaphylactic shock 76.03 10.30 237 170360 23280 42427458
Oxygen saturation decreased 75.97 10.30 481 170116 64206 42386532
Injury 75.04 10.30 228 170369 22088 42428650
Headache 74.61 10.30 1359 169238 238010 42212728
Drug abuse 72.91 10.30 198 170399 104573 42346165
Drug resistance 71.30 10.30 24 170573 34224 42416514
Hepatic function abnormal 71.11 10.30 61 170536 51506 42399232
Pancytopenia 70.84 10.30 238 170359 117505 42333233
Leukopenia 70.57 10.30 119 170478 74627 42376111
Neutropenia 66.98 10.30 495 170102 198936 42251802
Blood pressure fluctuation 66.61 10.30 248 170349 26660 42424078
Nightmare 65.69 10.30 235 170362 24777 42425961
Postnatal growth restriction 65.30 10.30 26 170571 174 42450564
Rhabdomyolysis 65.00 10.30 134 170463 77885 42372853
Hyperkalaemia 64.68 10.30 141 170456 80317 42370421
Cardiac failure 64.28 10.30 216 170381 106640 42344098
Hepatocellular injury 62.31 10.30 10 170587 23668 42427070
Fear 61.73 10.30 136 170461 10829 42439909
C-reactive protein increased 59.25 10.30 102 170495 63458 42387280
Cytomegalovirus infection 58.50 10.30 28 170569 32278 42418460
Hyperhidrosis 58.23 10.30 586 170011 89926 42360812
Anhedonia 57.61 10.30 107 170490 7533 42443205
Infusion site extravasation 56.19 10.30 88 170509 5393 42445345
Anaemia 55.12 10.30 790 169807 279488 42171250
Cholestasis 54.38 10.30 32 170565 32847 42417891
Nephrolithiasis 54.38 10.30 291 170306 36539 42414199
Pain in extremity 52.58 10.30 871 169726 149733 42301005
Urticaria 52.37 10.30 489 170108 73547 42377191
Cough 51.23 10.30 999 169598 177104 42273634
Renal impairment 51.02 10.30 247 170350 109981 42340757
Bone marrow failure 50.90 10.30 35 170562 33058 42417680
Pancreatitis acute 49.66 10.30 37 170560 33527 42417211
Hepatic cytolysis 47.49 10.30 24 170573 26820 42423918
Ear infection 46.06 10.30 134 170463 12670 42438068
Unevaluable event 46.00 10.30 264 170333 34024 42416714
Flushing 45.75 10.30 279 170318 36749 42413989
Toxicity to various agents 45.67 10.30 644 169953 228492 42222246
Melaena 45.21 10.30 53 170544 38693 42412045
Infusion site pain 45.07 10.30 79 170518 5316 42445422
Hypoglycaemia 44.78 10.30 109 170488 59745 42390993
Anxiety 44.48 10.30 694 169903 117866 42332872
Neck pain 44.20 10.30 237 170360 29777 42420961
Condition aggravated 42.86 10.30 760 169837 259994 42190744
Renal injury 42.73 10.30 127 170470 12153 42438585
Throat irritation 42.71 10.30 132 170465 12904 42437834
Heart rate increased 41.36 10.30 359 170238 52896 42397842
Nasopharyngitis 41.35 10.30 516 170081 83480 42367258
Altered state of consciousness 41.08 10.30 34 170563 29225 42421513
Pneumocystis jirovecii pneumonia 40.95 10.30 25 170572 25156 42425582
Lactic acidosis 40.94 10.30 74 170523 45187 42405551
Septic shock 40.37 10.30 209 170388 91463 42359275
Chest discomfort 39.53 10.30 409 170188 63207 42387531
Gamma-glutamyltransferase increased 39.50 10.30 43 170554 32454 42418284
Blood pressure diastolic increased 38.99 10.30 82 170515 6323 42444415
Mucosal inflammation 38.47 10.30 88 170509 49286 42401452
Pulmonary function test decreased 36.79 10.30 75 170522 5657 42445081
Liver disorder 35.69 10.30 65 170532 39579 42411159
Infusion site erythema 35.54 10.30 57 170540 3565 42447173
Sedation 34.77 10.30 225 170372 30250 42420488
Infusion site swelling 33.95 10.30 53 170544 3239 42447499
Bronchospasm 33.77 10.30 121 170476 12764 42437974
Illness 33.47 10.30 192 170405 24738 42426000
Floppy iris syndrome 33.30 10.30 19 170578 305 42450433
Extrapyramidal disorder 33.30 10.30 12 170585 16400 42434338
Eosinophilia 33.28 10.30 50 170547 32849 42417889
Nausea 33.17 10.30 1922 168675 394877 42055861
Nephropathy toxic 33.01 10.30 13 170584 16825 42433913
Haematotoxicity 32.92 10.30 3 170594 10982 42439756
Labelled drug-drug interaction medication error 32.29 10.30 11 170586 15571 42435167
Peripheral swelling 32.19 10.30 524 170073 89746 42360992
Disease progression 31.03 10.30 397 170200 143259 42307479
Stress 30.74 10.30 291 170306 43921 42406817
Suicide attempt 30.66 10.30 89 170508 46011 42404727
Infusion site pruritus 30.34 10.30 30 170567 1143 42449595
Poor venous access 30.14 10.30 80 170517 7172 42443566
Rhinorrhoea 29.94 10.30 224 170373 31570 42419168
Product used for unknown indication 29.74 10.30 30 170567 1171 42449567
Vitamin D deficiency 29.53 10.30 85 170512 7988 42442750
Cerebral infarction 29.06 10.30 50 170547 31119 42419619
Body temperature increased 28.13 10.30 158 170439 20200 42430538
Bronchopulmonary aspergillosis 28.00 10.30 22 170575 19407 42431331
Pulmonary fibrosis 27.53 10.30 40 170557 26641 42424097
Sleep disorder due to general medical condition, insomnia type 26.42 10.30 31 170566 1438 42449300
Epilepsy 26.26 10.30 40 170557 26131 42424607
Psychotic disorder 26.19 10.30 48 170549 29160 42421578
Unresponsive to stimuli 26.13 10.30 215 170382 31188 42419550
Post transplant lymphoproliferative disorder 26.01 10.30 3 170594 9117 42441621
Oropharyngeal pain 25.78 10.30 272 170325 42238 42408500
Peritonitis 25.73 10.30 22 170575 18611 42432127
Malignant neoplasm progression 25.52 10.30 294 170303 108106 42342632
Post concussion syndrome 25.47 10.30 13 170584 165 42450573
Cauda equina syndrome 25.23 10.30 25 170572 955 42449783
Muscle spasms 24.48 10.30 482 170115 85562 42365176
Lymphocyte count 24.47 10.30 14 170583 226 42450512
Bone pain 24.35 10.30 171 170426 23621 42427117
Electrocardiogram ST segment elevation 24.16 10.30 65 170532 5874 42444864
Infusion site bruising 23.98 10.30 24 170573 928 42449810
Thrombotic microangiopathy 23.59 10.30 15 170582 14767 42435971
Trigemino-cardiac reflex 23.52 10.30 16 170581 355 42450383
Therapeutic product effect incomplete 23.32 10.30 177 170420 70762 42379976
Chest pain 23.28 10.30 727 169870 138803 42311935
Delayed recovery from anaesthesia 23.27 10.30 26 170571 1143 42449595
Maternal exposure before pregnancy 23.26 10.30 25 170572 1052 42449686
Insurance issue 23.11 10.30 51 170546 4065 42446673
Abdominal discomfort 22.92 10.30 426 170171 74829 42375909
Weight decreased 22.79 10.30 1034 169563 206914 42243824
Progressive multifocal leukoencephalopathy 22.46 10.30 9 170588 11527 42439211
Neuroleptic malignant syndrome 22.34 10.30 32 170565 21440 42429298
Hypoxia 22.29 10.30 398 170199 69388 42381350
Procedural pain 22.27 10.30 62 170535 5717 42445021
Hypokalaemia 22.16 10.30 182 170415 71539 42379199
Hyponatraemia 22.04 10.30 280 170317 101182 42349556
Hepatotoxicity 22.00 10.30 42 170555 25125 42425613
Hypoaesthesia 21.92 10.30 405 170192 71058 42379680
Drug-induced liver injury 21.89 10.30 79 170518 38194 42412544
Hypocalcaemia 21.75 10.30 56 170541 30117 42420621
Epstein-Barr virus infection 21.69 10.30 6 170591 9712 42441026
Hypertension 21.61 10.30 846 169751 166358 42284380
Blood creatine phosphokinase increased 21.38 10.30 110 170487 48228 42402510
Immune reconstitution inflammatory syndrome 21.30 10.30 7 170590 10136 42440602
Poisoning deliberate 21.27 10.30 7 170590 10127 42440611
Pharyngeal paraesthesia 21.23 10.30 22 170575 887 42449851
Hypomagnesaemia 21.21 10.30 52 170545 28436 42422302
Post procedural complication 21.03 10.30 103 170494 12487 42438251
Jaundice 20.72 10.30 70 170527 34519 42416219
Akathisia 20.60 10.30 8 170589 10443 42440295
Haemorrhoids 20.59 10.30 128 170469 16969 42433769
Sinus disorder 20.59 10.30 75 170522 7975 42442763
Hepatitis 20.19 10.30 50 170547 27250 42423488
C-reactive protein abnormal 20.15 10.30 6 170591 9255 42441483
Hallucination, auditory 19.98 10.30 18 170579 14846 42435892
Diabetic ketoacidosis 19.84 10.30 37 170560 22330 42428408
Intentional self-injury 19.74 10.30 19 170578 15183 42435555
Lymphopenia 19.73 10.30 35 170562 21528 42429210
Contraindicated product administered 19.71 10.30 45 170552 25227 42425511
Intercepted product preparation error 19.71 10.30 3 170594 7386 42443352
Rebound effect 19.68 10.30 3 170594 7376 42443362
Hypotension 19.60 10.30 1238 169359 256393 42194345
Neutrophil count decreased 19.56 10.30 161 170436 63254 42387484
Parkinsonism 19.55 10.30 9 170588 10614 42440124
Respiratory symptom 19.54 10.30 10 170587 11096 42439642
Ischaemic stroke 19.53 10.30 37 170560 22196 42428542
Dental caries 19.50 10.30 53 170544 4819 42445919
Shock haemorrhagic 19.18 10.30 22 170575 16220 42434518
Upper respiratory tract infection 19.02 10.30 255 170342 41918 42408820
Drug eruption 18.90 10.30 40 170557 23035 42427703
Blood pressure decreased 18.74 10.30 333 170264 57999 42392739
Mental status changes 18.73 10.30 254 170343 41861 42408877
Adulterated product 18.72 10.30 19 170578 747 42449991
Throat tightness 18.59 10.30 82 170515 9517 42441221
Hepatitis cholestatic 18.59 10.30 8 170589 9816 42440922
Vasoplegia syndrome 18.55 10.30 36 170561 2619 42448119
Venoocclusive liver disease 18.54 10.30 9 170588 10293 42440445
Congestive cardiomyopathy 18.49 10.30 6 170591 8758 42441980
Acute graft versus host disease 18.47 10.30 5 170592 8210 42442528
Graft versus host disease 18.17 10.30 15 170582 12910 42437828
Blood pressure diastolic decreased 18.14 10.30 86 170511 10289 42440449
Bladder cancer 18.14 10.30 25 170572 17022 42433716
Haemophagocytic lymphohistiocytosis 18.14 10.30 28 170569 18194 42432544
Paranasal sinus hypersecretion 18.12 10.30 23 170574 1158 42449580
Anterior chamber cell 18.08 10.30 15 170582 453 42450285
Nasal congestion 18.00 10.30 189 170408 29312 42421426
Drug hypersensitivity 17.95 10.30 523 170074 98866 42351872
Diabetes mellitus 17.88 10.30 154 170443 59933 42390805
C-reactive protein decreased 17.72 10.30 32 170565 2204 42448534
Joint swelling 17.67 10.30 376 170221 67646 42383092
Normochromic normocytic anaemia 17.66 10.30 7 170590 9024 42441714
Infective pulmonary exacerbation of cystic fibrosis 17.66 10.30 70 170527 7748 42442990
Hepatic encephalopathy 17.61 10.30 24 170573 16418 42434320
Gastrointestinal haemorrhage 17.59 10.30 280 170317 97446 42353292
Febrile neutropenia 17.56 10.30 588 170009 185115 42265623
Oculocardiac reflex 17.51 10.30 9 170588 116 42450622
Ventricular tachycardia 17.37 10.30 191 170406 29969 42420769
Pleural thickening 17.29 10.30 15 170582 482 42450256
Spinal cord infarction 17.16 10.30 17 170580 649 42450089
Constipation 17.12 10.30 804 169793 161487 42289251
Lymphocyte count abnormal 16.96 10.30 31 170566 2156 42448582
Vitreous floaters 16.91 10.30 46 170551 4184 42446554
Prostate cancer 16.83 10.30 107 170490 44536 42406202
Urinary tract infection 16.73 10.30 518 170079 98766 42351972
Hepatic failure 16.68 10.30 87 170510 38013 42412725
Gastroenteritis viral 16.61 10.30 71 170526 8128 42442610
Hepatocellular carcinoma 16.61 10.30 6 170591 8188 42442550
Vein disorder 16.56 10.30 30 170567 2072 42448666
Pemphigoid 16.50 10.30 13 170584 11454 42439284
Hypogammaglobulinaemia 16.47 10.30 14 170583 11877 42438861
Polyneuropathy 16.44 10.30 31 170566 18630 42432108
Disseminated intravascular coagulation 16.38 10.30 48 170549 24746 42425992
Hip fracture 16.31 10.30 101 170496 13371 42437367
Influenza 16.26 10.30 344 170253 61831 42388907
Type IIa hyperlipidaemia 16.20 10.30 12 170585 306 42450432
Apnoea 16.14 10.30 68 170529 7735 42443003
Rheumatoid arthritis 15.73 10.30 248 170349 42192 42408546
Osteoarthritis 15.67 10.30 158 170439 24247 42426491
Cholangitis 15.64 10.30 12 170585 10715 42440023
Body temperature decreased 15.58 10.30 105 170492 14308 42436430
Tracheitis 15.57 10.30 20 170577 1019 42449719
Neuritis 15.55 10.30 3 170594 6217 42444521
Musculoskeletal chest pain 15.50 10.30 87 170510 11117 42439621
Cystitis haemorrhagic 15.49 10.30 5 170592 7324 42443414
Blood lactate dehydrogenase increased 15.47 10.30 53 170544 26028 42424710
Cerebral haemorrhage 15.42 10.30 92 170505 38874 42411864
Transplant rejection 15.41 10.30 19 170578 13569 42437169
Bronchitis 15.35 10.30 270 170327 46931 42403807
BK virus infection 15.32 10.30 8 170589 8776 42441962
Accident 15.31 10.30 59 170538 6444 42444294
Anal inflammation 15.30 10.30 30 170567 2199 42448539
Hospice care 15.20 10.30 71 170526 8442 42442296
Aspergillus infection 15.13 10.30 25 170572 15812 42434926
Localised infection 15.12 10.30 136 170461 20237 42430501
Electrocardiogram QT prolonged 15.11 10.30 121 170476 47824 42402914
Swelling 15.11 10.30 306 170291 54579 42396159
Aggression 15.08 10.30 109 170488 44054 42406684
Contusion 15.06 10.30 244 170353 41741 42408997
Vitreous disorder 14.92 10.30 9 170588 161 42450577
Multiple organ dysfunction syndrome 14.90 10.30 286 170311 96749 42353989
Paraesthesia oral 14.85 10.30 50 170547 5113 42445625
SARS-CoV-2 test negative 14.84 10.30 26 170571 1749 42448989
Corneal oedema 14.70 10.30 24 170573 1524 42449214
Disease recurrence 14.61 10.30 65 170532 29613 42421125
Eyelid rash 14.56 10.30 8 170589 119 42450619
Arthritis 14.54 10.30 243 170354 41822 42408916
Accidental exposure to product by child 14.48 10.30 24 170573 1543 42449195
Sudden death 14.32 10.30 28 170569 16601 42434137
Coma 14.31 10.30 141 170456 53413 42397325
Osteonecrosis 14.29 10.30 26 170571 15839 42434899
Inappropriate schedule of product administration 14.26 10.30 493 170104 95409 42355329
Dermatitis exfoliative generalised 14.16 10.30 3 170594 5821 42444917
Intentional product misuse 14.13 10.30 169 170428 61731 42389007
Purpura 14.12 10.30 16 170581 11863 42438875
Blood creatinine increased 14.04 10.30 334 170263 109669 42341069
Ascites 14.01 10.30 152 170445 56526 42394212
Hypertriglyceridaemia 13.93 10.30 12 170585 10114 42440624
Product adhesion issue 13.93 10.30 25 170572 1714 42449024
Tubulointerstitial nephritis 13.83 10.30 72 170525 31476 42419262
Vasodilatation 13.79 10.30 21 170576 1256 42449482
Lagophthalmos 13.78 10.30 8 170589 133 42450605
Toxic skin eruption 13.76 10.30 21 170576 13709 42437029
Nephrotic syndrome 13.70 10.30 9 170588 8709 42442029
Feeling abnormal 13.65 10.30 371 170226 69415 42381323
Metastases to liver 13.62 10.30 28 170569 16298 42434440
Pulmonary alveolar haemorrhage 13.60 10.30 24 170573 14792 42435946
Bronchial injury 13.57 10.30 3 170594 0 42450738
Rash maculo-papular 13.57 10.30 91 170506 37412 42413326
Neurological symptom 13.55 10.30 12 170585 9979 42440759
Hypertensive emergency 13.54 10.30 21 170576 1276 42449462
Eosinophilic granulomatosis with polyangiitis 13.46 10.30 9 170588 8629 42442109
Cytomegalovirus viraemia 13.44 10.30 13 170584 10364 42440374
Iris haemorrhage 13.42 10.30 4 170593 9 42450729
Gastrooesophageal reflux disease 13.40 10.30 254 170343 44769 42405969
Aplastic anaemia 13.34 10.30 18 170579 12366 42438372
Infusion site reaction 13.31 10.30 21 170576 1295 42449443
Foetal exposure during pregnancy 13.31 10.30 123 170474 47188 42403550
Orthostatic hypotension 13.28 10.30 70 170527 30500 42420238
Reperfusion arrhythmia 13.24 10.30 7 170590 96 42450642
Syringe issue 13.22 10.30 9 170588 8547 42442191
Dry gangrene 13.17 10.30 13 170584 494 42450244
Weight increased 13.16 10.30 543 170054 107440 42343298
Musculoskeletal stiffness 13.03 10.30 313 170284 57452 42393286
No adverse event 12.97 10.30 224 170373 38797 42411941
Cystitis bacterial 12.95 10.30 9 170588 207 42450531
Nervous system neoplasm 12.93 10.30 8 170589 150 42450588
Cardiac arrest 12.93 10.30 548 170049 108772 42341966
Febrile bone marrow aplasia 12.90 10.30 13 170584 10168 42440570
Appendix disorder 12.88 10.30 15 170582 690 42450048
Spinal meningeal cyst 12.86 10.30 7 170590 102 42450636
Discomfort 12.86 10.30 156 170441 25063 42425675
Penile torsion 12.86 10.30 4 170593 11 42450727
Hyperthermia malignant 12.79 10.30 31 170566 2627 42448111
Neutropenic sepsis 12.76 10.30 28 170569 15918 42434820
Paraesthesia ear 12.75 10.30 5 170592 32 42450706
Ventricular fibrillation 12.71 10.30 180 170417 29943 42420795
Potentiating drug interaction 12.67 10.30 5 170592 6463 42444275
Acute graft versus host disease in skin 12.60 10.30 7 170590 7417 42443321
Intracranial hypotension 12.54 10.30 12 170585 439 42450299
Injection site extravasation 12.53 10.30 34 170563 3088 42447650
Gastric cancer 12.47 10.30 6 170591 6897 42443841
Inappropriate antidiuretic hormone secretion 12.46 10.30 30 170567 16511 42434227
Neuralgia 12.37 10.30 157 170440 25490 42425248
Anaesthetic complication neurological 12.36 10.30 15 170582 721 42450017
Upper-airway cough syndrome 12.31 10.30 42 170555 4324 42446414
Tooth infection 12.30 10.30 64 170533 7947 42442791
Kidney transplant rejection 12.30 10.30 10 170587 8673 42442065
Nonreassuring foetal heart rate pattern 12.25 10.30 5 170592 36 42450702
Enterocolitis 12.22 10.30 13 170584 9916 42440822
Duodenal ulcer haemorrhage 12.21 10.30 4 170593 5804 42444934
Proteinuria 12.13 10.30 49 170548 22934 42427804
Seasonal allergy 12.13 10.30 64 170533 7991 42442747
Sleep disorder due to a general medical condition 12.11 10.30 33 170564 17420 42433318
Hand fracture 12.02 10.30 32 170565 2874 42447864
International normalised ratio increased 11.97 10.30 129 170468 48039 42402699
Pathogen resistance 11.97 10.30 17 170580 11433 42439305
Joint effusion 11.90 10.30 51 170546 5846 42444892
Intentional product use issue 11.89 10.30 374 170223 71459 42379279
Viral infection 11.87 10.30 140 170457 22343 42428395
Impaired work ability 11.84 10.30 86 170511 12005 42438733
Proctalgia 11.83 10.30 58 170539 7035 42443703
Rotator cuff syndrome 11.81 10.30 55 170542 6531 42444207
Allergic transfusion reaction 11.80 10.30 5 170592 40 42450698
Immune-mediated enterocolitis 11.78 10.30 4 170593 5673 42445065
Treatment failure 11.74 10.30 178 170419 62446 42388292
Snapping hip syndrome 11.73 10.30 4 170593 16 42450722
Neoplasm progression 11.72 10.30 68 170529 28932 42421806
Rash 11.58 10.30 1272 169325 275682 42175056
Tryptase increased 11.56 10.30 10 170587 320 42450418
Aqueous fibrin 11.56 10.30 6 170591 79 42450659
Administration site pruritus 11.53 10.30 4 170593 17 42450721
Head lag 11.51 10.30 3 170594 3 42450735
Vitreous degeneration 11.51 10.30 3 170594 3 42450735
Sleep study 11.51 10.30 3 170594 3 42450735
Mobility decreased 11.50 10.30 202 170395 35104 42415634
Colorectal cancer 11.45 10.30 3 170594 5035 42445703
Accidental overdose 11.44 10.30 168 170429 28162 42422576
Feeling hot 11.43 10.30 144 170453 23338 42427400
Delirium 11.37 10.30 145 170452 52374 42398364
Sciatica 11.37 10.30 59 170538 7318 42443420
Psoriasis 11.36 10.30 132 170465 48472 42402266
Angina pectoris 11.32 10.30 81 170516 32815 42417923
Oesophageal obstruction 11.32 10.30 13 170584 589 42450149
Incorrect drug administration rate 11.27 10.30 26 170571 2134 42448604
Encephalitis 11.26 10.30 12 170585 9146 42441592
Toxic epidermal necrolysis 11.20 10.30 62 170535 26688 42424050
Dermatitis exfoliative 11.15 10.30 7 170590 6940 42443798
Alanine aminotransferase increased 11.12 10.30 269 170328 88137 42362601
Aspiration joint 11.10 10.30 7 170590 136 42450602
COVID-19 11.08 10.30 569 170028 115379 42335359
Haematemesis 11.07 10.30 73 170524 30126 42420612
Throat clearing 11.06 10.30 13 170584 604 42450134
Neuromuscular blockade 11.03 10.30 10 170587 341 42450397
Renal tubular disorder 11.01 10.30 3 170594 4906 42445832
Failure to thrive 11.01 10.30 70 170527 9352 42441386
Tenderness 11.01 10.30 67 170530 8816 42441922
Treatment noncompliance 11.00 10.30 97 170500 37575 42413163
Chemical burn 10.98 10.30 10 170587 343 42450395
Withdrawal syndrome 10.97 10.30 27 170570 14748 42435990
Recalled product administered 10.93 10.30 14 170583 711 42450027
Negative pressure pulmonary oedema 10.93 10.30 13 170584 612 42450126
Eosinophilic pneumonia 10.89 10.30 3 170594 4871 42445867
Lung disorder 10.87 10.30 131 170466 47792 42402946
Haemarthrosis 10.87 10.30 38 170559 3960 42446778
Immunosuppressant drug level increased 10.83 10.30 9 170588 7722 42443016
Croup infectious 10.82 10.30 12 170585 523 42450215
Poisoning 10.81 10.30 27 170570 14672 42436066
Vitello-intestinal duct remnant 10.79 10.30 7 170590 143 42450595
Impaired quality of life 10.70 10.30 95 170502 14082 42436656
Anterior chamber fibrin 10.66 10.30 5 170592 52 42450686
Dust allergy 10.65 10.30 4 170593 5328 42445410
Postoperative renal failure 10.58 10.30 5 170592 53 42450685
Increased tendency to bruise 10.58 10.30 40 170557 4330 42446408
Skin discolouration 10.55 10.30 129 170468 20761 42429977
Dyspepsia 10.55 10.30 228 170369 41124 42409614
Pharyngitis streptococcal 10.54 10.30 37 170560 3863 42446875
Oesophageal carcinoma 10.54 10.30 14 170583 9682 42441056
Foetal growth restriction 10.49 10.30 4 170593 5279 42445459
Generalised tonic-clonic seizure 10.49 10.30 156 170441 26223 42424515
Angioedema 10.46 10.30 114 170483 42363 42408375
Small for dates baby 10.42 10.30 4 170593 5259 42445479
Bradyphrenia 10.42 10.30 4 170593 5258 42445480
Seizure like phenomena 10.40 10.30 17 170580 1080 42449658
Cytomegalovirus infection reactivation 10.35 10.30 18 170579 11160 42439578
Pneumonia lipoid 10.32 10.30 6 170591 100 42450638
Carbon dioxide decreased 10.31 10.30 25 170572 2119 42448619
Pemphigus 10.31 10.30 24 170573 1982 42448756
Tinnitus 10.31 10.30 168 170429 28770 42421968
Red blood cell spherocytes present 10.30 10.30 3 170594 6 42450732
Anorectal operation 10.30 10.30 3 170594 6 42450732

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 780.04 9.72 173 593428 242208 109753490
Drug interaction 732.82 9.72 967 592634 499216 109496482
Local anaesthetic systemic toxicity 682.72 9.72 405 593196 5132 109990566
Acute kidney injury 623.19 9.72 1573 592028 633857 109361841
Sinusitis 422.63 9.72 2884 590717 293804 109701894
Toxicity to various agents 383.90 9.72 1309 592292 479246 109516452
Myelosuppression 383.45 9.72 33 593568 94307 109901391
Infusion related reaction 336.50 9.72 3324 590277 377838 109617860
Neutropenia 327.35 9.72 980 592621 373640 109622058
Blood pressure diastolic abnormal 313.02 9.72 525 593076 25290 109970408
Anaemia 305.87 9.72 1705 591896 545381 109450317
Drug abuse 299.24 9.72 306 593295 177105 109818593
Nasopharyngitis 293.14 9.72 3322 590279 391039 109604659
Pancytopenia 278.10 9.72 434 593167 209179 109786519
Blood pressure systolic abnormal 268.15 9.72 480 593121 24370 109971328
Thrombocytopenia 257.44 9.72 982 592619 347903 109647795
Pain 244.14 9.72 6779 586822 948176 109047522
Blood pressure increased 242.50 9.72 2283 591318 256090 109739608
Drug reaction with eosinophilia and systemic symptoms 238.33 9.72 72 593529 82023 109913675
Blood pressure systolic increased 232.87 9.72 973 592628 82018 109913680
Blood pressure fluctuation 231.26 9.72 904 592697 73920 109921778
Back pain 227.40 9.72 3014 590587 367982 109627716
Cardiac failure 222.71 9.72 417 593184 187209 109808489
Muscle injury 219.18 9.72 1400 592201 139407 109856291
Hyperkalaemia 216.98 9.72 245 593356 135551 109860147
Irritable bowel syndrome 211.83 9.72 1559 592042 162656 109833042
Agranulocytosis 211.27 9.72 38 593563 61722 109933976
Peripheral swelling 208.65 9.72 3185 590416 400849 109594849
Hepatic function abnormal 203.14 9.72 113 593488 89182 109906516
Weight increased 202.27 9.72 3270 590331 416374 109579324
Folliculitis 201.28 9.72 1565 592036 166088 109829610
Rheumatoid arthritis 199.57 9.72 2472 591129 297141 109698557
Rhabdomyolysis 199.24 9.72 211 593390 120190 109875508
Maternal exposure during delivery 198.93 9.72 160 593441 3405 109992293
Headache 190.43 9.72 6135 587466 876242 109119456
Interstitial lung disease 190.05 9.72 283 593318 139051 109856647
Hyponatraemia 189.52 9.72 570 593031 217083 109778615
Toxic anterior segment syndrome 188.47 9.72 153 593448 3301 109992397
Drug resistance 187.90 9.72 37 593564 56337 109939361
Leukopenia 186.17 9.72 320 593281 148471 109847227
Septic shock 186.16 9.72 351 593250 157177 109838521
Cytomegalovirus infection 176.77 9.72 38 593563 54406 109941292
Cholestasis 174.32 9.72 64 593537 64454 109931244
Muscle spasticity 174.19 9.72 505 593096 35410 109960288
Fatigue 171.80 9.72 8071 585530 1207887 108787811
Hepatocellular injury 169.29 9.72 33 593568 50609 109945089
Heart rate increased 167.32 9.72 1333 592268 142501 109853197
Bursitis 166.16 9.72 1231 592370 128687 109867011
Gastrointestinal disorder 164.42 9.72 2004 591597 239948 109755750
Lower respiratory tract infection 164.09 9.72 2011 591590 241095 109754603
Bone marrow failure 160.36 9.72 55 593546 57793 109937905
Ear pain 158.77 9.72 636 592965 52590 109943108
Heart rate decreased 157.17 9.72 867 592734 81889 109913809
Hepatic cytolysis 154.95 9.72 51 593550 55002 109940696
Disease progression 153.37 9.72 730 592871 243304 109752394
Body temperature increased 151.55 9.72 639 592962 54074 109941624
Mucosal inflammation 150.82 9.72 176 593425 95965 109899733
Oxygen saturation decreased 149.63 9.72 1392 592209 155590 109840108
Renal impairment 145.72 9.72 520 593081 187925 109807773
Contusion 145.40 9.72 1902 591699 231459 109764239
Lactic acidosis 143.35 9.72 172 593429 92639 109903059
Malignant neoplasm progression 142.91 9.72 470 593131 174097 109821601
Night sweats 134.77 9.72 1202 592399 132781 109862917
Urticaria 133.70 9.72 2430 591171 316427 109679271
Anxiety 133.39 9.72 2597 591004 342481 109653217
Ill-defined disorder 131.94 9.72 1355 592246 155498 109840200
Febrile neutropenia 131.84 9.72 1077 592524 315690 109680008
Hypokalaemia 129.06 9.72 522 593079 181926 109813772
Impaired healing 128.72 9.72 1618 591983 195099 109800599
Anaphylactic reaction 126.81 9.72 1048 592553 113252 109882446
Pancreatitis acute 126.31 9.72 84 593517 60190 109935508
Temperature regulation disorder 126.09 9.72 238 593363 12588 109983110
Food allergy 125.60 9.72 309 593292 19639 109976059
Joint swelling 124.22 9.72 3184 590417 439661 109556037
Pain in extremity 123.97 9.72 3458 590143 483660 109512038
Coma 123.72 9.72 281 593320 117588 109878110
Hypoglycaemia 122.51 9.72 276 593325 115828 109879870
Gamma-glutamyltransferase increased 121.16 9.72 91 593510 61218 109934480
General physical health deterioration 121.08 9.72 1582 592019 423713 109571985
Arthralgia 119.54 9.72 5220 588381 774412 109221286
Neck pain 118.92 9.72 1095 592506 122035 109873663
Suicide attempt 112.20 9.72 242 593359 103152 109892546
Melaena 112.07 9.72 122 593479 68635 109927063
Pneumocystis jirovecii pneumonia 111.12 9.72 45 593556 42690 109953008
Blister 109.83 9.72 1773 591828 225603 109770095
Anaesthetic complication 102.23 9.72 111 593490 3495 109992203
Coeliac disease 101.24 9.72 480 593121 42707 109952991
Altered state of consciousness 101.03 9.72 96 593505 57530 109938168
Sinus disorder 99.96 9.72 394 593207 32334 109963364
Multiple organ dysfunction syndrome 99.93 9.72 446 593155 151264 109844434
Haematotoxicity 99.28 9.72 3 593598 21079 109974619
Chest discomfort 99.24 9.72 1395 592206 172453 109823245
Hypocalcaemia 97.93 9.72 124 593477 65242 109930456
Intentional self-injury 96.37 9.72 40 593561 37389 109958309
Sleep disorder due to general medical condition, insomnia type 96.28 9.72 928 592673 104715 109890983
Electrocardiogram QT prolonged 95.77 9.72 284 593317 108676 109887022
Illness 93.60 9.72 758 592843 81413 109914285
Helicobacter infection 91.51 9.72 1428 592173 180449 109815249
Rhinorrhoea 90.21 9.72 895 592706 101771 109893927
Toxic epidermal necrolysis 89.88 9.72 103 593498 56624 109939074
Migraine 89.15 9.72 1355 592246 170297 109825401
Blood pressure diastolic increased 86.95 9.72 260 593341 18547 109977151
Cardio-respiratory arrest 86.00 9.72 325 593276 115511 109880187
Osteonecrosis of jaw 85.35 9.72 79 593522 47938 109947760
Methaemoglobinaemia 85.06 9.72 166 593435 9002 109986696
Anaphylactic shock 84.83 9.72 520 593081 51026 109944672
Injury 84.00 9.72 1378 592223 175887 109819811
Bronchopulmonary aspergillosis 83.45 9.72 28 593573 29835 109965863
Drug eruption 82.26 9.72 100 593501 53559 109942139
Jaundice 81.06 9.72 120 593481 59116 109936582
Blood pressure diastolic decreased 80.62 9.72 394 593207 35491 109960207
Poisoning deliberate 80.31 9.72 21 593580 26310 109969388
Thrombotic microangiopathy 80.30 9.72 28 593573 29121 109966577
Alanine aminotransferase increased 80.03 9.72 617 592984 183156 109812542
Emotional distress 78.65 9.72 460 593141 44387 109951311
Platelet count decreased 78.35 9.72 824 592777 229619 109766079
Angioedema 77.32 9.72 270 593331 98230 109897468
Osteoarthritis 76.55 9.72 1392 592209 181231 109814467
Lymphopenia 76.36 9.72 62 593539 40108 109955590
Intentional overdose 75.46 9.72 410 593191 132091 109863607
Oropharyngeal pain 75.39 9.72 1081 592520 134195 109861503
Nephropathy toxic 74.66 9.72 27 593574 27451 109968247
Death 73.85 9.72 3034 590567 695835 109299863
Hepatic enzyme increased 71.99 9.72 2243 591358 318649 109677049
Tubulointerstitial nephritis 71.37 9.72 113 593488 54171 109941527
Hypersensitivity 70.90 9.72 2745 590856 401253 109594445
Post transplant lymphoproliferative disorder 70.82 9.72 3 593598 15610 109980088
Poisoning 70.39 9.72 34 593567 29071 109966627
Back injury 69.27 9.72 464 593137 46935 109948763
Finger deformity 69.16 9.72 356 593245 32736 109962962
Neuroleptic malignant syndrome 68.01 9.72 50 593551 34009 109961689
Sensory loss 67.71 9.72 261 593340 21196 109974502
Personality disorder 67.62 9.72 186 593415 12651 109983047
Hepatic failure 67.27 9.72 170 593431 68569 109927129
Cerebral infarction 67.12 9.72 109 593492 51729 109943969
Hyperglycaemia 66.95 9.72 233 593368 84857 109910841
Blood creatine phosphokinase increased 66.76 9.72 187 593414 72890 109922808
Blood creatinine increased 66.71 9.72 643 592958 182246 109813452
Gastrooesophageal reflux disease 66.61 9.72 1346 592255 178630 109817068
Insomnia 66.59 9.72 2464 591137 358126 109637572
Suspected suicide 65.53 9.72 4 593597 15195 109980503
Gastrointestinal haemorrhage 65.10 9.72 571 593030 164947 109830751
Throat irritation 64.83 9.72 501 593100 53051 109942647
Rash maculo-papular 64.11 9.72 195 593406 74027 109921671
Condition aggravated 64.10 9.72 3257 590344 731579 109264119
Product quality issue 63.66 9.72 665 592936 76634 109919064
Haemophagocytic lymphohistiocytosis 63.44 9.72 46 593555 31513 109964185
Hypomagnesaemia 63.28 9.72 144 593457 60226 109935472
Wound infection 62.87 9.72 793 592808 95672 109900026
Gangrene 62.82 9.72 212 593389 16129 109979569
Shock haemorrhagic 62.66 9.72 34 593567 27213 109968485
Renal failure 62.51 9.72 848 592753 225726 109769972
Aspartate aminotransferase increased 62.35 9.72 553 593048 159383 109836315
Pruritus 62.33 9.72 3764 589837 577796 109417902
Scoliosis 62.27 9.72 142 593459 8591 109987107
Musculoskeletal pain 61.95 9.72 1351 592250 181672 109814026
Upper respiratory tract infection 61.87 9.72 1020 592581 130308 109865390
Hepatitis cholestatic 61.86 9.72 10 593591 17556 109978142
Flushing 61.60 9.72 845 592756 103891 109891807
Carotid artery thrombosis 61.42 9.72 150 593451 9488 109986210
Graft versus host disease 61.31 9.72 13 593588 18793 109976905
Ascites 61.01 9.72 273 593328 92535 109903163
Orthostatic hypotension 60.91 9.72 169 593432 66080 109929618
Neurologic neglect syndrome 60.64 9.72 146 593455 9152 109986546
Sinus congestion 60.44 9.72 323 593278 30136 109965562
Transaminases increased 60.32 9.72 159 593442 63231 109932467
Sneezing 59.98 9.72 334 593267 31650 109964048
Stomatitis 59.81 9.72 1886 591715 268356 109727342
Inappropriate antidiuretic hormone secretion 59.80 9.72 56 593545 33795 109961903
Diabetic ketoacidosis 59.72 9.72 83 593518 41975 109953723
Bronchospasm 59.55 9.72 320 593281 29919 109965779
Respiratory tract congestion 59.05 9.72 324 593277 30533 109965165
Duodenal ulcer perforation 58.65 9.72 1307 592294 176393 109819305
Blood parathyroid hormone decreased 57.80 9.72 3 593598 13086 109982612
Transplant rejection 57.46 9.72 30 593571 24537 109971161
Anhedonia 57.42 9.72 198 593403 15230 109980468
Infusion site erythema 56.87 9.72 167 593434 11792 109983906
Toxic skin eruption 56.77 9.72 39 593562 27476 109968222
Fear 56.72 9.72 261 593340 22932 109972766
Wound 56.67 9.72 1654 591947 232783 109762915
Arterial occlusive disease 56.57 9.72 196 593405 15112 109980586
Peripheral venous disease 56.33 9.72 695 592906 83422 109912276
Acute respiratory distress syndrome 55.67 9.72 127 593474 53071 109942627
Peritonitis 55.22 9.72 56 593545 32551 109963147
Pleural thickening 55.03 9.72 79 593522 3320 109992378
Nasal congestion 55 9.72 786 592815 97496 109898202
Inspiratory capacity decreased 53.75 9.72 68 593533 2527 109993171
Gait inability 53.17 9.72 1028 592573 135348 109860350
Febrile bone marrow aplasia 53.13 9.72 14 593587 17451 109978247
Cough 52.70 9.72 3005 590596 458636 109537062
Anti-cyclic citrullinated peptide antibody positive 52.56 9.72 1314 592287 180670 109815028
International normalised ratio increased 52.49 9.72 263 593338 86509 109909189
Depressed level of consciousness 52.20 9.72 370 593231 111908 109883790
Infusion site pruritus 51.82 9.72 95 593506 4913 109990785
Chills 51.80 9.72 1365 592236 189215 109806483
Sepsis 51.43 9.72 1350 592251 325996 109669702
Device expulsion 51.24 9.72 54 593547 30837 109964861
Maternal exposure during pregnancy 51.05 9.72 1758 591843 253125 109742573
Hypercalcaemia 50.78 9.72 109 593492 46548 109949150
Aplastic anaemia 50.76 9.72 34 593567 24274 109971424
Aspergillus infection 50.64 9.72 38 593563 25578 109970120
Product label confusion 50.24 9.72 248 593353 22429 109973269
Multiple-drug resistance 50.22 9.72 6 593595 13229 109982469
Product prescribing error 50.18 9.72 127 593474 51204 109944494
Respiratory disorder 50.07 9.72 595 593006 70787 109924911
Epstein-Barr virus infection 49.92 9.72 19 593582 18719 109976979
Stevens-Johnson syndrome 49.87 9.72 111 593490 46790 109948908
Respiratory failure 49.75 9.72 834 592767 214498 109781200
Adjustment disorder 49.68 9.72 149 593452 10646 109985052
Neutropenic sepsis 49.61 9.72 55 593546 30691 109965007
Progressive multifocal leukoencephalopathy 49.36 9.72 37 593564 24919 109970779
Discomfort 49.24 9.72 1505 592096 213202 109782496
Parkinsonism 49.13 9.72 29 593572 22158 109973540
C-reactive protein increased 49.05 9.72 848 592753 217071 109778627
Muscle spasms 49.00 9.72 1891 591710 276266 109719432
Haematuria 48.84 9.72 254 593347 82751 109912947
Metabolic acidosis 48.70 9.72 324 593277 99420 109896278
Anaesthetic complication neurological 48.59 9.72 42 593559 991 109994707
Venoocclusive liver disease 48.58 9.72 11 593590 15196 109980502
Influenza 48.54 9.72 1220 592381 167881 109827817
Psychotic disorder 48.28 9.72 128 593473 50809 109944889
Cytomegalovirus infection reactivation 48.16 9.72 19 593582 18314 109977384
Syncope 47.92 9.72 781 592820 201755 109793943
Haematemesis 47.76 9.72 160 593441 58948 109936750
Polyneuropathy 47.67 9.72 61 593540 31951 109963747
Pleural fibrosis 47.48 9.72 84 593517 4224 109991474
Cerebral haemorrhage 47.11 9.72 184 593417 64784 109930914
Stress 46.98 9.72 811 592790 104537 109891161
Fluid retention 46.86 9.72 739 592862 93568 109902130
Neutrophil count decreased 46.77 9.72 419 593182 120522 109875176
Bronchial secretion retention 46.65 9.72 91 593510 4933 109990765
Panniculitis 46.44 9.72 13 593588 15569 109980129
Hypothyroidism 46.39 9.72 217 593384 72682 109923016
Infusion site pain 46.35 9.72 201 593400 17218 109978480
Presbyacusis 46.34 9.72 66 593535 2753 109992945
Infusion site swelling 46.09 9.72 137 593464 9740 109985958
Ischaemic stroke 46.08 9.72 95 593506 41168 109954530
Cytomegalovirus viraemia 45.71 9.72 19 593582 17745 109977953
Granuloma skin 45.70 9.72 4 593597 11279 109984419
Proteinuria 45.66 9.72 91 593510 39927 109955771
Swelling 45.61 9.72 2313 591288 348728 109646970
Labelled drug-drug interaction medication error 45.56 9.72 54 593547 29248 109966450
Pathogen resistance 45.31 9.72 19 593582 17653 109978045
Hallucination, auditory 45.08 9.72 45 593556 26352 109969346
Taste disorder 44.97 9.72 543 593058 64844 109930854
Nail disorder 44.72 9.72 492 593109 57443 109938255
Immunodeficiency 44.62 9.72 359 593242 38479 109957219
Kounis syndrome 44.10 9.72 98 593503 5827 109989871
Abdominal discomfort 44.01 9.72 2559 591042 391299 109604399
Acute graft versus host disease 43.89 9.72 8 593593 12873 109982825
Pemphigus 43.73 9.72 1483 592118 213087 109782611
Proctitis 43.72 9.72 18 593583 16909 109978789
Arthropathy 43.63 9.72 1924 591677 285598 109710100
Anterior spinal artery syndrome 43.34 9.72 22 593579 200 109995498
Neovascularisation 43.30 9.72 50 593551 1687 109994011
Acute myeloid leukaemia 43.19 9.72 87 593514 38023 109957675
Corneal oedema 43.18 9.72 68 593533 3105 109992593
Skin toxicity 43.12 9.72 6 593595 11777 109983921
Infusion site extravasation 43.03 9.72 149 593452 11485 109984213
Metastases to liver 42.53 9.72 78 593523 35308 109960390
Myelodysplastic syndrome 42.12 9.72 86 593515 37398 109958300
Therapeutic product effect decreased 42.10 9.72 1657 591944 242659 109753039
Pemphigoid 41.92 9.72 27 593574 19680 109976018
Drug-induced liver injury 41.74 9.72 427 593174 119640 109876058
Bacterial disease carrier 41.62 9.72 56 593545 2213 109993485
Hypoaesthesia 41.55 9.72 2074 591527 312149 109683549
Akathisia 41.37 9.72 20 593581 17093 109978605
Hyperthyroidism 41.29 9.72 58 593543 29203 109966495
Palmar-plantar erythrodysaesthesia syndrome 40.49 9.72 101 593500 40924 109954774
Acute graft versus host disease in skin 40.43 9.72 5 593596 10735 109984963
Influenza like illness 40.28 9.72 683 592918 87729 109907969
Colitis microscopic 40.25 9.72 11 593590 13383 109982315
Blood lactate dehydrogenase increased 40.08 9.72 114 593487 44220 109951478
Asthma 40.01 9.72 1684 591917 248607 109747091
Cholangitis 39.63 9.72 19 593582 16316 109979382
Liver function test abnormal 39.44 9.72 213 593388 68737 109926961
Off label use 39.31 9.72 7275 586326 1492910 108502788
Hyperhidrosis 39.31 9.72 1299 592302 185999 109809699
Intentional product use issue 39.19 9.72 1666 591935 246240 109749458
Hepatic encephalopathy 38.89 9.72 57 593544 28199 109967499
Serotonin syndrome 38.88 9.72 174 593427 58979 109936719
Tumour lysis syndrome 38.73 9.72 66 593535 30735 109964963
Posterior reversible encephalopathy syndrome 38.63 9.72 77 593524 33784 109961914
Joint range of motion decreased 38.60 9.72 891 592710 120941 109874757
Nephrotic syndrome 38.59 9.72 13 593588 13818 109981880
Pneumonia aspiration 38.10 9.72 267 593334 80966 109914732
Hepatotoxicity 37.86 9.72 193 593408 63207 109932491
Prostate cancer 37.68 9.72 92 593509 37549 109958149
Blood magnesium increased 37.65 9.72 71 593530 3752 109991946
Pericarditis 37.26 9.72 1484 592117 217630 109778068
BK virus infection 37.13 9.72 12 593589 13094 109982604
Disorientation 36.83 9.72 225 593376 70446 109925252
Sinus operation 36.48 9.72 61 593540 2930 109992768
Immunosuppressant drug level increased 36.43 9.72 9 593592 11715 109983983
Hepatocellular carcinoma 36.23 9.72 5 593596 9875 109985823
Musculoskeletal stiffness 36.18 9.72 1843 591758 277979 109717719
Systemic infection 35.93 9.72 5 593596 9814 109985884
Sudden death 35.79 9.72 47 593554 24348 109971350
Ulcer haemorrhage 35.45 9.72 225 593376 22346 109973352
Adverse reaction 35.34 9.72 276 593325 29318 109966380
Nephrolithiasis 35.26 9.72 525 593076 65687 109930011
Foetal death 35.21 9.72 175 593426 15870 109979828
Enterocolitis 35.09 9.72 30 593571 18919 109976779
Spinal cord injury 35.07 9.72 44 593557 1621 109994077
Seasonal allergy 35.04 9.72 203 593398 19519 109976179
Pulmonary tuberculosis 35.03 9.72 4 593597 9135 109986563
Agitation 34.93 9.72 413 593188 112638 109883060
Colorectal cancer 34.91 9.72 4 593597 9110 109986588
Eosinophilia 34.81 9.72 176 593425 57760 109937938
Dermatitis bullous 34.65 9.72 26 593575 17503 109978195
Abdominal pain upper 34.47 9.72 2244 591357 346867 109648831
Glossodynia 34.43 9.72 1489 592112 220515 109775183
Rheumatoid nodule 34.21 9.72 35 593566 20261 109975437
Exposure during pregnancy 33.81 9.72 1156 592445 166268 109829430
Cutaneous vasculitis 33.76 9.72 13 593588 12716 109982982
Sleep disorder 33.69 9.72 1345 592256 197299 109798399
Anterior chamber cell 33.60 9.72 37 593564 1184 109994514
Drug dependence 33.56 9.72 146 593455 49874 109945824
Adulterated product 33.53 9.72 36 593565 1119 109994579
Immune reconstitution inflammatory syndrome 33.47 9.72 23 593578 16203 109979495
Poor venous access 33.43 9.72 236 593365 24286 109971412
Prescribed overdose 33.39 9.72 658 592943 86923 109908775
Mucormycosis 33.33 9.72 8 593593 10620 109985078
Affect lability 33.22 9.72 192 593409 18445 109977253
Lip dry 32.97 9.72 736 592865 99347 109896351
Dermatitis exfoliative 32.84 9.72 10 593591 11337 109984361
Disseminated intravascular coagulation 32.51 9.72 113 593488 41173 109954525
Hypogammaglobulinaemia 32.30 9.72 36 593565 20040 109975658
Hand deformity 32.00 9.72 1457 592144 217049 109778649
Bladder cancer 31.98 9.72 37 593564 20255 109975443
Weight fluctuation 31.89 9.72 216 593385 21929 109973769
Live birth 31.73 9.72 537 593064 68947 109926751
Haematoma 31.62 9.72 184 593417 58292 109937406
Feeling hot 31.61 9.72 675 592926 90431 109905267
Cystitis haemorrhagic 31.51 9.72 13 593588 12196 109983502
Adrenal insufficiency 31.41 9.72 119 593482 42271 109953427
Dermatitis exfoliative generalised 31.16 9.72 10 593591 10962 109984736
Congestive cardiomyopathy 30.91 9.72 19 593582 14200 109981498
Erysipelas 30.87 9.72 16 593585 13142 109982556
Blepharospasm 30.82 9.72 439 593162 54412 109941286
Potentiating drug interaction 30.70 9.72 12 593589 11631 109984067
Hyperbilirubinaemia 30.67 9.72 75 593526 30596 109965102
Kidney transplant rejection 30.55 9.72 13 593588 11974 109983724
Macular degeneration 30.49 9.72 43 593558 21616 109974082
Oesophageal carcinoma 30.18 9.72 12 593589 11512 109984186
Skin necrosis 30.00 9.72 43 593558 21469 109974229
Chronic graft versus host disease 29.90 9.72 7 593594 9450 109986248
Urine leukocyte esterase positive 29.74 9.72 64 593537 3722 109991976
Myocarditis 29.66 9.72 74 593527 29981 109965717
Hypoalbuminaemia 29.65 9.72 70 593531 28904 109966794
Cauda equina syndrome 29.60 9.72 46 593555 2076 109993622
Hallucination, visual 29.46 9.72 111 593490 39494 109956204
Contraindicated product administered 29.44 9.72 1622 591979 246645 109749053
Metastases to lung 29.39 9.72 49 593552 23014 109972684
Osteopenia 29.27 9.72 212 593389 21997 109973701
Procedural hypotension 29.12 9.72 50 593551 2455 109993243
Motor dysfunction 28.80 9.72 227 593374 24179 109971519
Infusion site bruising 28.51 9.72 62 593539 3632 109992066
Rib fracture 28.50 9.72 292 593309 33478 109962220
Diabetes mellitus 28.47 9.72 369 593232 99012 109896686
Diffuse large B-cell lymphoma 28.44 9.72 26 593575 15872 109979826
Dry mouth 28.36 9.72 1329 592272 198619 109797079
Osteonecrosis 28.18 9.72 90 593511 33651 109962047
Urine abnormality 28.18 9.72 110 593491 8986 109986712
Respiratory arrest 28.14 9.72 190 593411 58109 109937589
Trigemino-cardiac reflex 28.13 9.72 22 593579 449 109995249
Wheezing 28.04 9.72 1656 591945 253574 109742124
Gastric cancer 27.96 9.72 12 593589 10996 109984702
Product tampering 27.80 9.72 22 593579 457 109995241
Hypoaesthesia oral 27.65 9.72 171 593430 16831 109978867
Hyperammonaemia 27.62 9.72 20 593581 13712 109981986
Joint stiffness 27.61 9.72 511 593090 66732 109928966
Cataract 27.60 9.72 589 593012 78896 109916802
Eating disorder 27.58 9.72 270 593331 30588 109965110
Unevaluable event 27.51 9.72 459 593142 58768 109936930
Body height decreased 27.43 9.72 121 593480 10442 109985256
Electrolyte imbalance 27.40 9.72 104 593497 36924 109958774
Pulmonary alveolar haemorrhage 27.39 9.72 41 593560 20109 109975589
Product adhesion issue 27.37 9.72 54 593547 2952 109992746
Second primary malignancy 27.35 9.72 34 593567 18034 109977664
Acute myocardial infarction 27.07 9.72 303 593298 83474 109912224
Pleural effusion 27.07 9.72 736 592865 176973 109818725
Lower limb fracture 27.03 9.72 561 593040 74787 109920911
Nocardiosis 26.96 9.72 4 593597 7482 109988216
Encephalitis 26.92 9.72 37 593564 18802 109976896
Red blood cell sedimentation rate abnormal 26.89 9.72 57 593544 24452 109971246
Neuralgia 26.84 9.72 387 593214 48091 109947607
Leukoencephalopathy 26.80 9.72 8 593593 9187 109986511
Rebound effect 26.74 9.72 24 593577 14782 109980916
Infection 26.46 9.72 2273 591328 359927 109635771
Mixed liver injury 26.45 9.72 16 593585 12063 109983635
Bradyphrenia 26.44 9.72 15 593586 11713 109983985
Drug use disorder 26.34 9.72 35 593566 18039 109977659
Graft versus host disease in skin 26.31 9.72 6 593595 8248 109987450
Injection site pain 26.30 9.72 740 592861 177182 109818516
Skin haemorrhage 26.12 9.72 225 593376 24602 109971096
Hypertransaminasaemia 26.12 9.72 57 593544 24198 109971500
Intercepted product preparation error 26.10 9.72 3 593598 6817 109988881
Renal injury 26.04 9.72 181 593420 18532 109977166
Graft versus host disease in gastrointestinal tract 25.78 9.72 8 593593 8960 109986738
Vaginal discharge 25.77 9.72 35 593566 17873 109977825
Cyst 25.63 9.72 164 593437 16332 109979366
Grip strength decreased 25.59 9.72 587 593014 79587 109916111
Disease recurrence 25.55 9.72 206 593395 60578 109935120
Dyspepsia 25.54 9.72 1262 592339 189703 109805995
Ear infection 25.51 9.72 476 593125 62256 109933442
Pneumonitis 25.45 9.72 275 593326 76256 109919442
Infusion site reaction 25.18 9.72 172 593429 17510 109978188
Eosinophilic granulomatosis with polyangiitis 25.06 9.72 13 593588 10673 109985025
Hypothermia 25.00 9.72 66 593535 26236 109969462
Incorrect route of product administration 24.99 9.72 483 593118 63578 109932120
Abortion spontaneous 24.91 9.72 97 593504 34185 109961513
Deafness neurosensory 24.83 9.72 110 593491 9509 109986189
Cytopenia 24.69 9.72 81 593520 30035 109965663
Renal tubular disorder 24.50 9.72 5 593596 7424 109988274
Diabetes mellitus inadequate control 24.46 9.72 80 593521 29695 109966003
Type IIa hyperlipidaemia 24.45 9.72 21 593580 491 109995207
Systemic lupus erythematosus 24.40 9.72 1631 591970 252707 109742991
Paraesthesia 24.40 9.72 1761 591840 274760 109720938
Skin ulcer 24.38 9.72 221 593380 63424 109932274
Upper gastrointestinal haemorrhage 24.31 9.72 163 593438 49933 109945765
Aggression 24.28 9.72 202 593399 59008 109936690
Breast cancer stage III 24.25 9.72 576 593025 78541 109917157
Subileus 24.22 9.72 3 593598 6434 109989264
Psychomotor retardation 24.18 9.72 6 593595 7786 109987912
Lagophthalmos 24.00 9.72 22 593579 562 109995136
Hepatitis fulminant 23.96 9.72 8 593593 8552 109987146
Hepatitis acute 23.79 9.72 40 593561 18726 109976972
Ileus paralytic 23.73 9.72 17 593584 11720 109983978
Eyelid rash 23.71 9.72 20 593581 456 109995242
Peripheral sensory neuropathy 23.60 9.72 33 593568 16647 109979051
Diffuse large B-cell lymphoma recurrent 23.55 9.72 3 593598 6296 109989402
Cardiac failure congestive 23.36 9.72 624 592977 150376 109845322
Wrong technique in product usage process 23.33 9.72 329 593272 87019 109908679
Femoral neck fracture 23.14 9.72 20 593581 12547 109983151
Mania 23.12 9.72 48 593553 20748 109974950
Clostridium difficile colitis 23.01 9.72 139 593462 43639 109952059
Immune-mediated enterocolitis 23.00 9.72 13 593588 10172 109985526
Maternal exposure timing unspecified 22.93 9.72 192 593409 20821 109974877
Dry eye 22.91 9.72 424 593177 55369 109940329
Face oedema 22.87 9.72 97 593504 33372 109962326
Liver function test increased 22.84 9.72 630 592971 87918 109907780
Breast cancer stage II 22.77 9.72 236 593365 27139 109968559
Insurance issue 22.76 9.72 115 593486 10497 109985201
Atelectasis 22.74 9.72 299 593302 36413 109959285
Dyskinesia 22.72 9.72 172 593429 51274 109944424
Concussion 22.65 9.72 122 593479 11416 109984282
Antipsychotic drug level increased 22.56 9.72 5 593596 7010 109988688
Salpingo-oophorectomy unilateral 22.55 9.72 25 593576 806 109994892
Oliguria 22.53 9.72 41 593560 18616 109977082
Cytokine release syndrome 22.43 9.72 255 593346 70051 109925647
Asphyxia 22.31 9.72 26 593575 14189 109981509
Limb injury 22.26 9.72 304 593297 37332 109958366
Memory impairment 22.23 9.72 1281 592320 195663 109800035
Nightmare 22.22 9.72 312 593289 38551 109957147
Hypersensitivity vasculitis 22.20 9.72 5 593596 6932 109988766
Cognitive disorder 22.19 9.72 333 593268 87178 109908520
Cerebral haematoma 22.18 9.72 12 593589 9620 109986078
Adenovirus infection 22.13 9.72 16 593585 10978 109984720
Sinus headache 22.09 9.72 77 593524 5955 109989743
Cystitis 21.86 9.72 486 593115 65550 109930148
Ear pruritus 21.84 9.72 87 593514 7173 109988525
Systemic toxicity 21.82 9.72 17 593584 345 109995353
Sulphaemoglobinaemia 21.74 9.72 21 593580 574 109995124
Throat tightness 21.69 9.72 275 593326 33214 109962484
Palpitations 21.68 9.72 1054 592547 158158 109837540
Ventilation perfusion mismatch 21.67 9.72 24 593577 773 109994925
Duodenal ulcer haemorrhage 21.66 9.72 8 593593 8029 109987669
Tooth disorder 21.59 9.72 248 593353 29261 109966437
Lymphoproliferative disorder 21.55 9.72 6 593595 7212 109988486
Red cell distribution width increased 21.48 9.72 165 593436 17437 109978261
Metastases to bone 21.39 9.72 91 593510 31281 109964417
Organising pneumonia 21.35 9.72 27 593574 14216 109981482
Myopathy 21.25 9.72 66 593535 24894 109970804
Basal cell carcinoma 21.13 9.72 149 593452 45121 109950577
Polyarthritis 20.89 9.72 44 593557 18919 109976779
Nerve compression 20.68 9.72 116 593485 11021 109984677
Lupus vulgaris 20.58 9.72 275 593326 33608 109962090
Productive cough 20.56 9.72 779 592822 113526 109882172
Pineal gland cyst 20.43 9.72 14 593587 231 109995467
Drug level increased 20.39 9.72 161 593440 47558 109948140
Colitis 20.27 9.72 407 593194 101916 109893782
Abdominal pain 20.27 9.72 2427 591174 510562 109485136
Epigastric discomfort 20.26 9.72 99 593502 8916 109986782
Rhythm idioventricular 20.25 9.72 23 593578 762 109994936
Hyperpyrexia 20.17 9.72 9 593592 8060 109987638
Substance use disorder 20.08 9.72 7 593594 7283 109988415
Tryptase increased 19.99 9.72 25 593576 918 109994780
Hypertriglyceridaemia 19.96 9.72 35 593566 16119 109979579
Klebsiella infection 19.95 9.72 49 593552 19960 109975738
Ileus 19.83 9.72 91 593510 30638 109965060
Infusion site haemorrhage 19.79 9.72 62 593539 4536 109991162
Cestode infection 19.73 9.72 15 593586 293 109995405
Blood alkaline phosphatase increased 19.72 9.72 265 593336 70670 109925028
Suicidal ideation 19.72 9.72 370 593231 93567 109902131
Aqueous fibrin 19.69 9.72 13 593588 201 109995497
Haemoptysis 19.68 9.72 267 593334 71087 109924611
Arteriosclerosis coronary artery 19.61 9.72 69 593532 25049 109970649
Dermatitis allergic 19.54 9.72 56 593545 21668 109974030
Haemolytic anaemia 19.50 9.72 53 593548 20867 109974831
Onychomadesis 19.45 9.72 349 593252 45314 109950384
Sternal fracture 19.44 9.72 50 593551 3266 109992432
X-ray abnormal 19.43 9.72 300 593301 37817 109957881
Post-traumatic neck syndrome 19.40 9.72 43 593558 2552 109993146
Carbuncle 19.36 9.72 31 593570 1436 109994262
Aplasia 19.34 9.72 9 593592 7864 109987834
Subcutaneous drug absorption impaired 19.33 9.72 87 593514 7572 109988126
Arrhythmia 19.32 9.72 260 593341 69315 109926383
Lichenoid keratosis 19.27 9.72 5 593596 6297 109989401
Anti-neutrophil cytoplasmic antibody positive vasculitis 19.26 9.72 3 593598 5414 109990284
Spinal meningioma benign 19.23 9.72 10 593591 96 109995602
Myocardial infarction 19.14 9.72 839 592762 191244 109804454
Chronic kidney disease 19.10 9.72 291 593310 76000 109919698
Post procedural complication 19.04 9.72 223 593378 26435 109969263
Blood folate decreased 18.95 9.72 40 593561 2295 109993403
Gastroenteritis 18.95 9.72 126 593475 38674 109957024
Coordination abnormal 18.90 9.72 213 593388 25015 109970683
Infective pulmonary exacerbation of cystic fibrosis 18.89 9.72 140 593461 14631 109981067
Cervicogenic headache 18.79 9.72 13 593588 218 109995480
Psychiatric decompensation 18.76 9.72 4 593597 5761 109989937
Salivary hypersecretion 18.71 9.72 41 593560 17380 109978318
Back disorder 18.67 9.72 183 593418 20739 109974959
JC virus infection 18.65 9.72 3 593598 5287 109990411
Pneumonia cytomegaloviral 18.61 9.72 7 593594 6947 109988751
Body temperature decreased 18.56 9.72 290 593311 36645 109959053
Hypopyon 18.42 9.72 30 593571 1410 109994288
Muscular weakness 18.40 9.72 1561 592040 246907 109748791
Hyperuricaemia 18.40 9.72 31 593570 14500 109981198
Normochromic normocytic anaemia 18.31 9.72 26 593575 13031 109982667
Synovitis 18.30 9.72 1709 591892 272383 109723315
Red blood cell sedimentation rate 18.29 9.72 3 593598 5211 109990487
Hyperthermia 18.29 9.72 56 593545 21216 109974482
Transplant dysfunction 18.28 9.72 11 593590 8317 109987381
Blood bilirubin increased 18.27 9.72 292 593309 75680 109920018
Systemic candida 18.21 9.72 16 593585 9958 109985740
Calcification of muscle 18.21 9.72 12 593589 185 109995513
Hyperlactacidaemia 18.11 9.72 11 593590 8275 109987423
Tardive dyskinesia 18.10 9.72 28 593573 13551 109982147
Haemoglobin decreased 18.03 9.72 1122 592479 247605 109748093
Embolia cutis medicamentosa 18.02 9.72 24 593577 939 109994759
Decreased appetite 17.95 9.72 2258 591343 473588 109522110
Acute generalised exanthematous pustulosis 17.94 9.72 58 593543 21606 109974092
Infusion site urticaria 17.86 9.72 27 593574 1189 109994509
Therapy partial responder 17.78 9.72 121 593480 36940 109958758
Varicella zoster virus infection 17.74 9.72 6 593595 6362 109989336
Cytomegalovirus chorioretinitis 17.74 9.72 8 593593 7120 109988578
Pregnancy 17.60 9.72 378 593223 50689 109945009
Gastroenteritis viral 17.57 9.72 250 593351 30976 109964722
SARS-CoV-2 test positive 17.57 9.72 153 593448 16782 109978916
Hepatitis toxic 17.54 9.72 5 593596 5916 109989782
Spirometry abnormal 17.51 9.72 4 593597 5493 109990205
Dystonia 17.51 9.72 75 593526 25730 109969968
Weight decreased 17.50 9.72 2814 590787 465243 109530455
Subdural haematoma 17.50 9.72 119 593482 36335 109959363
Lupus vasculitis 17.48 9.72 19 593582 599 109995099
Drug dose omission by device 17.44 9.72 32 593569 14484 109981214
Infusion site discharge 17.43 9.72 35 593566 1938 109993760
Lymphoma 17.41 9.72 53 593548 20118 109975580
Incorrect drug administration rate 17.38 9.72 67 593534 5441 109990257
Meningitis chemical 17.32 9.72 15 593586 355 109995343
Liver disorder 17.29 9.72 607 592994 141636 109854062
Subacute cutaneous lupus erythematosus 17.24 9.72 3 593598 4991 109990707
Enterococcal infection 17.24 9.72 54 593547 20312 109975386
Rash 17.19 9.72 4800 588801 816164 109179534
Large intestine perforation 17.15 9.72 40 593561 16589 109979109
Chest pain 17.07 9.72 2288 591313 374087 109621611
Stress cardiomyopathy 17.03 9.72 144 593457 15662 109980036
Arthritis infective 17.02 9.72 105 593496 10324 109985374
Pulse abnormal 17.00 9.72 55 593546 4094 109991604
Disability assessment scale score increased 16.95 9.72 56 593545 4214 109991484
Immune-mediated myositis 16.94 9.72 6 593595 6180 109989518
Delayed recovery from anaesthesia 16.90 9.72 37 593564 2178 109993520
Exposure via ingestion 16.79 9.72 3 593598 4897 109990801
Enteritis 16.78 9.72 50 593551 19106 109976592
Hypovolaemic shock 16.77 9.72 33 593568 14550 109981148
Haemorrhoids 16.77 9.72 277 593324 35395 109960303
Treatment noncompliance 16.74 9.72 283 593318 72707 109922991
Infusion site discomfort 16.72 9.72 33 593568 1804 109993894
Unintentional medical device removal 16.68 9.72 14 593587 8909 109986789
Eosinophilic pneumonia 16.64 9.72 9 593592 7218 109988480
Dyspnoea 16.63 9.72 6389 587212 1100483 108895215
Intestinal ischaemia 16.62 9.72 39 593562 16140 109979558
Extrapyramidal disorder 16.61 9.72 89 593512 28778 109966920
Dissociation 16.55 9.72 17 593584 9825 109985873
White blood cells urine positive 16.46 9.72 82 593519 7442 109988256
Erythema multiforme 16.44 9.72 58 593543 21039 109974659
Ulcer 16.39 9.72 150 593451 42966 109952732
Drug effective for unapproved indication 16.35 9.72 32 593569 14135 109981563
Epstein-Barr virus associated lymphoproliferative disorder 16.32 9.72 3 593598 4799 109990899
Subarachnoid haemorrhage 16.31 9.72 93 593508 29609 109966089
Acute graft versus host disease in intestine 16.27 9.72 5 593596 5634 109990064
Pancreatitis 16.22 9.72 380 593221 93153 109902545
Lip pruritus 16.18 9.72 27 593574 1295 109994403
Pulse absent 16.17 9.72 110 593491 11182 109984516
Cardiovascular disorder 16.16 9.72 65 593536 22695 109973003
Coma scale abnormal 16.13 9.72 17 593584 9709 109985989
Faecaloma 16.08 9.72 35 593566 14873 109980825
COVID-19 pneumonia 16.02 9.72 125 593476 37018 109958680
Osteosclerosis 15.99 9.72 57 593544 4458 109991240
Cytomegalovirus colitis 15.96 9.72 9 593592 7052 109988646
Acute myeloid leukaemia recurrent 15.86 9.72 4 593597 5135 109990563
Floppy iris syndrome 15.86 9.72 14 593587 340 109995358
Radiculopathy 15.85 9.72 52 593549 19284 109976414
Tuberculosis 15.85 9.72 46 593555 17728 109977970
Erectile dysfunction 15.85 9.72 49 593552 18507 109977191
Hallucinations, mixed 15.81 9.72 14 593587 8679 109987019
Allergy to immunoglobulin therapy 15.76 9.72 10 593591 144 109995554
Pulmonary function test decreased 15.75 9.72 90 593511 8610 109987088
Urinary sediment present 15.74 9.72 39 593562 2489 109993209
Dental caries 15.74 9.72 120 593481 12653 109983045
Secondary immunodeficiency 15.73 9.72 3 593598 4673 109991025
Hepatitis B 15.72 9.72 17 593584 9595 109986103
Necrosis 15.71 9.72 23 593578 11383 109984315
Haemodialysis 15.70 9.72 46 593555 17673 109978025
Neuropathy peripheral 15.68 9.72 794 592807 178483 109817215
Infusion site mass 15.68 9.72 31 593570 1697 109994001
Postnatal growth restriction 15.68 9.72 6 593595 25 109995673
Petechiae 15.68 9.72 68 593533 23249 109972449
Dehydration 15.67 9.72 1289 592312 278222 109717476
Rash pustular 15.67 9.72 28 593573 12801 109982897
Psoriatic arthropathy 15.66 9.72 1243 592358 195518 109800180
Neoplasm progression 15.63 9.72 248 593353 64347 109931351
COVID-19 15.62 9.72 1523 592078 243537 109752161
Congenital hiatus hernia 15.62 9.72 7 593594 6252 109989446
Arteriosclerosis 15.59 9.72 74 593527 24693 109971005
Pharyngeal disorder 15.56 9.72 41 593560 2718 109992980
Multiple allergies 15.55 9.72 116 593485 12147 109983551
Extradural abscess 15.54 9.72 34 593567 2000 109993698
Diarrhoea 15.52 9.72 5688 587913 1133817 108861881
Catatonia 15.35 9.72 23 593578 11277 109984421
Carbon dioxide decreased 15.35 9.72 58 593543 4666 109991032
Oedema peripheral 15.34 9.72 1537 592064 327123 109668575
Cachexia 15.33 9.72 29 593572 12976 109982722
Gynaecomastia 15.28 9.72 17 593584 9473 109986225
Post concussion syndrome 15.27 9.72 19 593582 694 109995004
Oesophagitis 15.18 9.72 91 593510 28624 109967074
Pulseless electrical activity 15.16 9.72 147 593454 16610 109979088
Haemolytic uraemic syndrome 15.16 9.72 4 593597 4981 109990717
Hemiplegia 15.15 9.72 188 593413 22594 109973104
Obesity 15.13 9.72 749 592852 112602 109883096
Soft tissue injury 15.12 9.72 36 593565 2240 109993458
Pneumonia bacterial 15.09 9.72 81 593520 26180 109969518
Muscle rigidity 15.01 9.72 72 593529 23959 109971739
Encephalopathy 14.99 9.72 326 593275 80729 109914969
Dermatitis contact 14.97 9.72 127 593474 13826 109981872
Superinfection 14.95 9.72 66 593535 5697 109990001
Menstruation delayed 14.87 9.72 31 593570 1763 109993935
Autoimmune haemolytic anaemia 14.86 9.72 21 593580 10546 109985152
Mouth ulceration 14.81 9.72 176 593425 47962 109947736
Brain abscess 14.80 9.72 9 593592 6765 109988933
Autoimmune disorder 14.73 9.72 458 593143 65025 109930673
Myoclonus 14.73 9.72 110 593491 32888 109962810
Normal newborn 14.69 9.72 181 593420 21715 109973983
Hepatic necrosis 14.68 9.72 19 593582 9903 109985795
Oculocardiac reflex 14.65 9.72 9 593592 122 109995576
Transplant failure 14.54 9.72 6 593595 5629 109990069
Torsade de pointes 14.54 9.72 67 593534 22533 109973165
Overdose 14.54 9.72 1069 592532 232725 109762973
Breast cancer female 14.53 9.72 28 593573 12440 109983258
Aplasia pure red cell 14.52 9.72 18 593583 9560 109986138
Hypercholesterolaemia 14.46 9.72 611 592990 90226 109905472
Facet joint syndrome 14.46 9.72 647 592954 96181 109899517
Impaired quality of life 14.45 9.72 234 593367 29783 109965915
Hallucination 14.44 9.72 424 593177 101008 109894690
Vasculitis 14.43 9.72 123 593478 35750 109959948
Pancreatic carcinoma 14.38 9.72 37 593564 14835 109980863
Linear IgA disease 14.38 9.72 3 593598 4386 109991312
Therapeutic response decreased 14.34 9.72 401 593200 96098 109899600
Nausea 14.34 9.72 7071 586530 1228619 108767079
Duodenal ulcer 14.32 9.72 55 593546 19459 109976239
Poor quality sleep 14.32 9.72 221 593380 27856 109967842
Upper respiratory tract inflammation 14.29 9.72 3 593598 4368 109991330
Obstruction 14.27 9.72 65 593536 5687 109990011
Miosis 14.24 9.72 65 593536 21918 109973780
Blue toe syndrome 14.20 9.72 18 593583 670 109995028
Joint destruction 14.17 9.72 23 593578 10920 109984778
Bacterial test 14.17 9.72 24 593577 1165 109994533
Endometrial disorder 14.12 9.72 18 593583 674 109995024
Injection site erythema 14.09 9.72 391 593210 93785 109901913
Product used for unknown indication 14.09 9.72 32 593569 1931 109993767
Disseminated tuberculosis 14.08 9.72 5 593596 5141 109990557
Hepatosplenomegaly 14.02 9.72 10 593591 6909 109988789
Hyperprolactinaemia 14.00 9.72 9 593592 6566 109989132
Hepatitis C 13.99 9.72 29 593572 12544 109983154
Limb mass 13.96 9.72 50 593551 3919 109991779
Stenotrophomonas infection 13.93 9.72 7 593594 5851 109989847
Exostosis 13.91 9.72 334 593267 45622 109950076
Incision site swelling 13.90 9.72 13 593588 341 109995357
Mycobacterial disease carrier 13.85 9.72 5 593596 17 109995681
Toxic encephalopathy 13.84 9.72 39 593562 15175 109980523
Fibromyalgia 13.82 9.72 1081 592520 169828 109825870
Haematochezia 13.80 9.72 494 593107 115030 109880668
Feeling abnormal 13.80 9.72 1138 592463 179573 109816125
Delusion 13.80 9.72 73 593528 23682 109972016
Flail chest 13.79 9.72 8 593593 97 109995601
Peritonitis bacterial 13.77 9.72 22 593579 10511 109985187
Body temperature fluctuation 13.67 9.72 48 593553 3725 109991973
Nerve root injury 13.66 9.72 7 593594 65 109995633
Partial seizures 13.65 9.72 25 593576 11324 109984374
Myoglobin blood increased 13.64 9.72 3 593598 4229 109991469
Oral candidiasis 13.64 9.72 164 593437 44596 109951102
Monoclonal immunoglobulin present 13.57 9.72 37 593564 2503 109993195
Guillain-Barre syndrome 13.53 9.72 23 593578 10721 109984977
Apnoea 13.52 9.72 122 593479 13517 109982181
Gestational hypertension 13.43 9.72 34 593567 2200 109993498
Hypocholesterolaemia 13.36 9.72 69 593532 6352 109989346
Drug withdrawal syndrome 13.36 9.72 135 593466 37919 109957779
Therapeutic product effect incomplete 13.33 9.72 1027 592574 222778 109772920
Affective disorder 13.31 9.72 25 593576 11216 109984482
Pseudomembranous colitis 13.26 9.72 9 593592 6382 109989316
Ketoacidosis 13.26 9.72 21 593580 10066 109985632
Sputum culture 13.24 9.72 12 593589 302 109995396
Exposure to toxic agent 13.21 9.72 31 593570 12827 109982871
Bone cyst 13.20 9.72 46 593555 3557 109992141
Endophthalmitis 13.10 9.72 82 593519 8105 109987593
Lipodystrophy acquired 13.07 9.72 4 593597 4520 109991178
Arthritis 13.06 9.72 1057 592544 166529 109829169
Injection site joint infection 13.05 9.72 7 593594 72 109995626
Labelled drug-drug interaction issue 13.03 9.72 3 593598 4098 109991600
Uterine leiomyoma 13.03 9.72 79 593522 7721 109987977
White blood cell count increased 13.01 9.72 408 593193 96434 109899264
Adjustment disorder with depressed mood 13.00 9.72 318 593283 43565 109952133
Haematoma muscle 12.98 9.72 3 593598 4087 109991611
Pneumatosis intestinalis 12.96 9.72 16 593585 8513 109987185
Blood urea increased 12.96 9.72 212 593389 54745 109940953
Platelet aggregation inhibition 12.96 9.72 10 593591 200 109995498
Squamous cell carcinoma of skin 12.94 9.72 48 593553 17155 109978543
Renal cancer 12.93 9.72 32 593569 13002 109982696
Circulatory collapse 12.92 9.72 158 593443 42835 109952863
Urine analysis abnormal 12.92 9.72 72 593529 6825 109988873
Spinal cord infarction 12.87 9.72 22 593579 1076 109994622
Persecutory delusion 12.87 9.72 9 593592 6282 109989416
Fear of eating 12.83 9.72 15 593586 513 109995185
Pharyngeal paraesthesia 12.82 9.72 50 593551 4082 109991616
Trigeminal palsy 12.81 9.72 7 593594 75 109995623
Specific gravity urine increased 12.78 9.72 15 593586 515 109995183
Metastases to central nervous system 12.77 9.72 71 593530 22746 109972952
Haemorrhage intracranial 12.72 9.72 97 593504 28872 109966826
Coronary artery stenosis 12.72 9.72 35 593566 13723 109981975
Abnormal behaviour 12.69 9.72 141 593460 38898 109956800
Pyelonephritis acute 12.66 9.72 12 593589 7201 109988497
Neurological decompensation 12.62 9.72 11 593590 6872 109988826
Libido increased 12.60 9.72 36 593565 2503 109993195
Skin sensitisation 12.57 9.72 22 593579 1097 109994601
Depressive symptom 12.56 9.72 16 593585 8398 109987300
Photosensitivity reaction 12.55 9.72 83 593518 25506 109970192
Retching 12.53 9.72 181 593420 22501 109973197
Pulmonary embolism 12.49 9.72 986 592615 213488 109782210
Spinal epidural haemorrhage 12.49 9.72 12 593589 326 109995372
Dysaesthesia 12.48 9.72 11 593590 6836 109988862
Renal tubular necrosis 12.48 9.72 104 593497 30371 109965327
Exercise tolerance decreased 12.47 9.72 29 593572 12038 109983660
Blood cholesterol increased 12.46 9.72 1153 592448 183632 109812066
Implant site bruising 12.46 9.72 12 593589 327 109995371
Granulocyte count decreased 12.45 9.72 3 593598 3971 109991727
Vasoplegia syndrome 12.42 9.72 60 593541 5379 109990319
Hepatic fibrosis 12.40 9.72 15 593586 8051 109987647
Neutropenic colitis 12.39 9.72 15 593586 8050 109987648
Cardiac failure acute 12.37 9.72 77 593524 24001 109971697
Arteriovenous fistula occlusion 12.36 9.72 15 593586 534 109995164
Syringe issue 12.36 9.72 20 593581 9505 109986193
Dyspnoea at rest 12.33 9.72 16 593585 8330 109987368
Migraine with aura 12.29 9.72 44 593557 3448 109992250
Lung perforation 12.27 9.72 8 593593 121 109995577
Staphylococcal bacteraemia 12.27 9.72 47 593554 16641 109979057
Hostility 12.21 9.72 37 593564 2659 109993039
Renal tubular acidosis 12.20 9.72 5 593596 4710 109990988
Cardiac failure chronic 12.13 9.72 36 593565 13775 109981923
Acute lymphocytic leukaemia 12.12 9.72 8 593593 5757 109989941
Rectal haemorrhage 12.02 9.72 523 593078 119310 109876388
Bronchitis 12.01 9.72 989 592612 156043 109839655
Drug tolerance 12.00 9.72 47 593554 16538 109979160
Migraine without aura 11.99 9.72 16 593585 627 109995071
Purtscher retinopathy 11.97 9.72 10 593591 225 109995473
Vital capacity decreased 11.89 9.72 31 593570 2042 109993656
Dermatitis 11.86 9.72 94 593507 27743 109967955
Complex regional pain syndrome 11.84 9.72 34 593567 2371 109993327
Skin discolouration 11.83 9.72 346 593255 48700 109946998
Escherichia infection 11.80 9.72 77 593524 23739 109971959
Allergic transfusion reaction 11.78 9.72 10 593591 230 109995468
Fixed eruption 11.77 9.72 4 593597 4228 109991470
Ligament sprain 11.74 9.72 135 593466 15933 109979765
Dust allergy 11.74 9.72 9 593592 5992 109989706
Drug tolerance decreased 11.73 9.72 93 593508 27447 109968251
Pneumonia pneumococcal 11.70 9.72 6 593595 4959 109990739
Red blood cells urine positive 11.70 9.72 57 593544 5128 109990570
Coagulopathy 11.68 9.72 152 593449 40759 109954939
Staphylococcal sepsis 11.67 9.72 51 593550 17403 109978295
Corneal epithelium defect 11.66 9.72 19 593582 893 109994805
Oesophageal varices haemorrhage 11.62 9.72 6 593595 4939 109990759
Claustrophobia 11.62 9.72 26 593575 1553 109994145
Neuromuscular blockade 11.62 9.72 17 593584 727 109994971
Acute febrile neutrophilic dermatosis 11.58 9.72 6 593595 4930 109990768
Implant site pain 11.57 9.72 32 593569 2183 109993515
Disturbance in attention 11.57 9.72 249 593352 61746 109933952
Lactose intolerance 11.55 9.72 37 593564 2739 109992959
Vascular purpura 11.51 9.72 3 593598 3768 109991930
Muscle strain 11.51 9.72 101 593500 11101 109984597
Somnolence 11.51 9.72 1409 592192 296040 109699658
Anal sphincter atony 11.48 9.72 14 593587 501 109995197
Iris haemorrhage 11.45 9.72 4 593597 12 109995686
Azotaemia 11.45 9.72 23 593578 10062 109985636
Anterior chamber fibrin 11.43 9.72 10 593591 240 109995458
Musculoskeletal chest pain 11.42 9.72 218 593383 28629 109967069
Infusion site rash 11.41 9.72 33 593568 2310 109993388
Swollen tongue 11.39 9.72 242 593359 60120 109935578
Injection site nerve damage 11.39 9.72 7 593594 95 109995603
Hiatus hernia strangulated 11.38 9.72 11 593590 301 109995397
Haemorrhagic stroke 11.36 9.72 37 593564 13752 109981946
Nervous system disorder 11.36 9.72 112 593489 31609 109964089
Sputum discoloured 11.35 9.72 212 593389 27733 109967965
Portal hypertension 11.33 9.72 18 593583 8619 109987079
Vein collapse 11.33 9.72 23 593578 1284 109994414
Ototoxicity 11.32 9.72 4 593597 4127 109991571
B-cell lymphoma 11.32 9.72 13 593588 7141 109988557
Pericardial haemorrhage 11.30 9.72 7 593594 5210 109990488
BRASH syndrome 11.30 9.72 3 593598 3720 109991978
Device infusion issue 11.26 9.72 39 593562 3006 109992692
Hypertension 11.23 9.72 2989 590612 507095 109488603
Product substitution issue 11.21 9.72 75 593526 22986 109972712
Premenstrual syndrome 11.18 9.72 15 593586 591 109995107
Hot flush 11.16 9.72 447 593154 65589 109930109
Overlap syndrome 11.10 9.72 85 593516 8974 109986724
Breast cancer stage I 11.08 9.72 14 593587 7373 109988325
Upper-airway cough syndrome 11.04 9.72 132 593469 15725 109979973
Hepatitis 11.01 9.72 384 593217 89670 109906028
Magnesium deficiency 10.93 9.72 17 593584 768 109994930
Peripheral nerve injury 10.91 9.72 21 593580 1127 109994571
Cytomegalovirus test positive 10.90 9.72 13 593588 7023 109988675
Left ventricle outflow tract obstruction 10.89 9.72 14 593587 529 109995169
Pyelonephritis 10.88 9.72 85 593516 25165 109970533
Thrombocytosis 10.87 9.72 25 593576 10419 109985279
Pneumocystis jirovecii infection 10.86 9.72 5 593596 4395 109991303
Medical device site abscess 10.83 9.72 9 593592 201 109995497
Foot fracture 10.79 9.72 195 593406 25351 109970347
Lip oedema 10.79 9.72 15 593586 7585 109988113
Foreign body 10.77 9.72 38 593563 2957 109992741
Withdrawal syndrome 10.74 9.72 112 593489 31268 109964430
Vitritis 10.72 9.72 35 593566 2618 109993080
Device leakage 10.67 9.72 47 593554 16001 109979697
Intervertebral disc degeneration 10.66 9.72 146 593455 17939 109977759
Lichen sclerosus 10.66 9.72 21 593580 1147 109994551
Inappropriate schedule of product administration 10.65 9.72 1249 592352 202388 109793310
Epstein-Barr viraemia 10.64 9.72 3 593598 3576 109992122
Haemoperitoneum 10.64 9.72 8 593593 5380 109990318
Female genital tract fistula 10.61 9.72 49 593552 16470 109979228
Hepatic cancer 10.60 9.72 28 593573 11128 109984570
Band sensation 10.59 9.72 20 593581 1058 109994640
Snapping hip syndrome 10.58 9.72 4 593597 16 109995682
Substance abuse 10.58 9.72 33 593568 12430 109983268
Blood urine present 10.57 9.72 186 593415 24059 109971639
Pneumonia klebsiella 10.55 9.72 12 593589 6620 109989078
Depression 10.54 9.72 1896 591705 315439 109680259
Conjunctivitis allergic 10.54 9.72 13 593588 6918 109988780
Bacteraemia 10.51 9.72 162 593439 42228 109953470
Device related infection 10.50 9.72 149 593452 39370 109956328
Thoracic operation 10.49 9.72 10 593591 269 109995429
Vascular malformation 10.47 9.72 17 593584 797 109994901
Confusional state 10.46 9.72 2748 590853 465932 109529766
Dermatitis atopic 10.45 9.72 194 593407 25347 109970351
Bradypnoea 10.45 9.72 19 593582 8630 109987068
Atonic urinary bladder 10.45 9.72 8 593593 158 109995540
Respiratory rate increased 10.43 9.72 191 593410 24892 109970806
Drug intolerance 10.39 9.72 2398 591203 404114 109591584
Salpingo-oophorectomy 10.39 9.72 5 593596 40 109995658
Mean arterial pressure decreased 10.38 9.72 13 593588 478 109995220
Acute psychosis 10.38 9.72 7 593594 4980 109990718
Premature rupture of membranes 10.35 9.72 6 593595 4631 109991067
Spinal osteoarthritis 10.34 9.72 159 593442 20024 109975674
Mycotic allergy 10.34 9.72 10 593591 5944 109989754
Thyroiditis 10.34 9.72 12 593589 6561 109989137
Acute coronary syndrome 10.34 9.72 77 593524 23035 109972663
Cryptococcosis 10.33 9.72 6 593595 4625 109991073
Immune-mediated lung disease 10.31 9.72 8 593593 5295 109990403
Dysponesis 10.29 9.72 5 593596 41 109995657
Metabolic disorder 10.27 9.72 26 593575 10484 109985214
Tooth infection 10.25 9.72 172 593429 22044 109973654
Abortion induced 10.25 9.72 17 593584 8002 109987696
Pneumocephalus 10.24 9.72 13 593588 485 109995213
Polyomavirus viraemia 10.17 9.72 3 593598 3471 109992227
Epidural analgesia 10.16 9.72 8 593593 165 109995533
Human papilloma virus test positive 10.14 9.72 15 593586 648 109995050
Chemical burn 10.14 9.72 16 593585 732 109994966
Spinal anaesthesia 10.09 9.72 7 593594 118 109995580
Testicular mass 10.09 9.72 7 593594 118 109995580
Urinary casts present 10.09 9.72 7 593594 118 109995580
Ataxia 10.08 9.72 108 593493 30000 109965698
Medical device site cellulitis 10.08 9.72 9 593592 222 109995476
Deafness permanent 10.06 9.72 18 593583 913 109994785
Lung disorder 10.05 9.72 1109 592492 178938 109816760
Hepatic steatosis 10.04 9.72 193 593408 48638 109947060
Madarosis 10.02 9.72 41 593560 3422 109992276
Tooth abscess 10.01 9.72 149 593452 18640 109977058
Haemorrhage subcutaneous 9.98 9.72 9 593592 5530 109990168
Delirium 9.97 9.72 608 592993 134417 109861281
Hand-foot-and-mouth disease 9.95 9.72 16 593585 744 109994954
Radiation pneumonitis 9.94 9.72 6 593595 4530 109991168
C-reactive protein abnormal 9.94 9.72 817 592784 128878 109866820
Therapy interrupted 9.92 9.72 198 593403 49624 109946074
Coronary artery disease 9.88 9.72 301 593300 71389 109924309
Accidental exposure to product 9.88 9.72 199 593402 49809 109945889
Ejection fraction decreased 9.87 9.72 157 593444 40723 109954975
Gastric ulcer haemorrhage 9.85 9.72 25 593576 10069 109985629
Procedure aborted 9.84 9.72 8 593593 173 109995525
Pancreatitis necrotising 9.84 9.72 9 593592 5492 109990206
Vitamin D deficiency 9.83 9.72 147 593454 18405 109977293
Viral haemorrhagic cystitis 9.83 9.72 3 593598 3396 109992302
Essential hypertension 9.82 9.72 74 593527 7773 109987925
N-terminal prohormone brain natriuretic peptide increased 9.82 9.72 11 593590 6110 109989588
Klebsiella sepsis 9.82 9.72 5 593596 4148 109991550
Enterobacter infection 9.82 9.72 10 593591 5801 109989897
Creatinine urine decreased 9.82 9.72 11 593590 359 109995339
Coronavirus infection 9.81 9.72 23 593578 9522 109986176
Lung adenocarcinoma 9.77 9.72 23 593578 9508 109986190
Seronegative arthritis 9.76 9.72 37 593564 13140 109982558

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01CA06 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Adrenergic and dopaminergic agents
ATC C05AX06 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Other agents for treatment of hemorrhoids and anal fissures for topical use
ATC R01AA04 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Sympathomimetics, plain
ATC R01AB01 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Sympathomimetics, combinations excl. corticosteroids
ATC R01BA03 RESPIRATORY SYSTEM
NASAL PREPARATIONS
NASAL DECONGESTANTS FOR SYSTEMIC USE
Sympathomimetics
ATC R01BA53 RESPIRATORY SYSTEM
NASAL PREPARATIONS
NASAL DECONGESTANTS FOR SYSTEMIC USE
Sympathomimetics
ATC S01FB01 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Sympathomimetics excl. antiglaucoma preparations
ATC S01FB51 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Sympathomimetics excl. antiglaucoma preparations
ATC S01GA05 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Sympathomimetics used as decongestants
ATC S01GA55 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Sympathomimetics used as decongestants
FDA MoA N0000009917 Adrenergic alpha1-Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D009184 Mydriatics
MeSH PA D013566 Sympathomimetics
MeSH PA D014662 Vasoconstrictor Agents
MeSH PA D014663 Nasal Decongestants
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D020011 Protective Agents
MeSH PA D058646 Adrenergic alpha-1 Receptor Agonists
FDA EPC N0000186105 alpha-1 Adrenergic Agonist
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35524 sympathomimetic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35569 ฮฑ-adrenergic agonist
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:38147 cardiotonic drug
CHEBI has role CHEBI:50267 protective agent
CHEBI has role CHEBI:50513 mydriatic agent
CHEBI has role CHEBI:50514 vasoconstrictor agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:77715 nasal decongestant
CHEBI has role CHEBI:51177 antitussive

Related Drugs by ATC class:

C01CA Adrenergic and dopaminergic agents 25 drugs
amezinium metilsulfatearbutaminecafedrinedimetofrinedobutaminedopaminedopexaminedroxidopaephedrineepinephrineetilefrinefenoldopam show all 25 →
C05AX Other agents for treatment of hemorrhoids and anal fissures for topical use 1 drug
tribenoside
R01AA Sympathomimetics, plain 13 drugs
cyclopentamineephedrineepinephrinefenoxazolineindanazolinemetizolinenaphazolineoxymetazolinetetryzolinetramazolinetuaminoheptanetymazoline show all 13 →
R01AB Sympathomimetics, combinations excl. corticosteroids 6 drugs
ephedrinenaphazolineoxymetazolinetetryzolinetuaminoheptanexylometazoline
R01BA Sympathomimetics 2 drugs
phenylpropanolaminepseudoephedrine
S01FB Sympathomimetics excl. antiglaucoma preparations 3 drugs
ephedrineibopamineketorolac
S01GA Sympathomimetics used as decongestants 6 drugs
brimonidinenaphazolineoxedrineoxymetazolinetetryzolinexylometazoline

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Proctitis indication 3951002 DOID:3127
Sinus headache indication 4969004
Vasomotor rhinitis indication 8229003 DOID:4730
Dilated pupil indication 37125009
Cough indication 49727002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Hemorrhoids indication 70153002 DOID:9746
Red eye indication 75705005
Sneezing indication 76067001
Rectal pain indication 77880009
Common cold indication 82272006 DOID:10459
Pruritus ani indication 90446007
Headache disorder indication 230461009
Influenza-like symptoms indication 315642008
Seasonal allergic rhinitis indication 367498001
Fever indication 386661006
Allergic conjunctivitis indication 473460002 DOID:11204
Prevention of intraoperative miosis indication
Prevention of Posterior Synechiae indication
Maintenance of intraoperative mydriasis indication
Postoperative ocular pain in intraocular lens replacement surgery indication
Priapism off-label use 6273006 DOID:9286
Low blood pressure off-label use 45007003
Metabolic alkalosis contraindication 1388004
Brain damage contraindication 2470005
Anuria contraindication 2472002 DOID:2983
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Goiter contraindication 3716002 DOID:12176
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Hyperbilirubinemia contraindication 14783006 DOID:2741
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Pulmonary edema contraindication 19242006 DOID:11396
Lowered convulsive threshold contraindication 19260006
Hashimoto thyroiditis contraindication 21983002
Myocardial infarction contraindication 22298006 DOID:5844
Disorder of the central nervous system contraindication 23853001 DOID:331
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Acute tuberculosis contraindication 25629007
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Bronchitis contraindication 32398004 DOID:6132
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypernatremia contraindication 39355002
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Anxiety contraindication 48694002
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Paralytic ileus contraindication 55525008 DOID:8442
Heart disease contraindication 56265001 DOID:114
Peptic reflux disease contraindication 57643001
Acute nephropathy contraindication 58574008
Metabolic acidosis contraindication 59455009
Hepatic failure contraindication 59927004
Perforation of tympanic membrane contraindication 60442001
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Psychotic disorder contraindication 69322001
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Disorder of brain contraindication 81308009 DOID:936
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Oliguria contraindication 83128009
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Epilepsy contraindication 84757009 DOID:1826
Pulmonary emphysema contraindication 87433001
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Myasthenia gravis contraindication 91637004 DOID:437
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Anemia due to enzyme deficiency contraindication 111577008
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Open wound contraindication 125643001
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Drug-induced psychosis contraindication 191483003 DOID:1742
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Myocardial dysfunction contraindication 233928007
Arterial aneurysm contraindication 233981004
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Hypocomplementemic urticarial vasculitis contraindication 239945009
Rhabdomyolysis contraindication 240131006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Drowsy contraindication 271782001
Peripheral edema contraindication 271809000
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Bone marrow depression contraindication 307762000
Infective otitis media contraindication 312218008
Panic disorder contraindication 371631005 DOID:594
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Pseudomembranous enterocolitis contraindication 397683000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Traumatic injury contraindication 417746004
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Acute erosive gastritis contraindication 444926003
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000
Acute exacerbation of asthma contraindication 708038006
Nervousness contraindication
Predisposition to Glaucoma contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.15 acidic
pKa2 13.64 acidic
pKa3 8.71 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
2.5%;1% MYDCOMBI EYENOVIA N215352 May 5, 2023 DISCN SPRAY, METERED OPHTHALMIC 10839960 July 15, 2031 METHOD OF ADMINISTERING AN EFFECTIVE DOSE OF TROPICAMIDE AND PHENYLEPHRINE HYDROCHLORIDE TO AN EYE
2.5%;1% MYDCOMBI EYENOVIA N215352 May 5, 2023 DISCN SPRAY, METERED OPHTHALMIC 11398306 July 15, 2031 METHOD OF ADMINISTERING AN EFFECTIVE DOSE OF TROPICAMIDE AND PHENYLEPHRINE HYDROCHLORIDE TO AN EYE
2.5%;1% MYDCOMBI EYENOVIA N215352 May 5, 2023 DISCN SPRAY, METERED OPHTHALMIC 11839487 July 15, 2031 METHOD OF ADMINISTERING AN EFFECTIVE DOSE OF TROPICAMIDE AND PHENYLEPHRINE HYDROCHLORIDE TO AN EYE
10% PHENYLEPHRINE HYDROCHLORIDE PARAGON BIOTECK N203510 March 21, 2013 RX SOLUTION/DROPS OPHTHALMIC 8859623 Nov. 14, 2033 DILATION OF THE PUPIL
2.5% PHENYLEPHRINE HYDROCHLORIDE PARAGON BIOTECK N203510 March 21, 2013 RX SOLUTION/DROPS OPHTHALMIC 8859623 Nov. 14, 2033 DILATION OF THE PUPIL

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
2.5%;1% MYDCOMBI EYENOVIA N215352 May 5, 2023 DISCN SPRAY, METERED OPHTHALMIC May 5, 2026 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Alpha-1D adrenergic receptor GPCR AGONIST IC50 5.90 WOMBAT-PK CHEMBL
Alpha-1B adrenergic receptor GPCR AGONIST Ki 6.90 WOMBAT-PK CHEMBL
Alpha-1A adrenergic receptor GPCR AGONIST Ki 5.30 WOMBAT-PK CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 6.41 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 5.96 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 5.90 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 6.57 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 5.21 CHEMBL
Alpha-1B adrenergic receptor GPCR EC50 8 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 4.89 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 6.03 CHEMBL

External reference:

IDSource
4017847 VUID
N0000146204 NUI
D00511 KEGG_DRUG
61-76-7 SECONDARY_CAS_RN
1416-03-1 SECONDARY_CAS_RN
17162-39-9 SECONDARY_CAS_RN
4017845 VANDF
4017847 VANDF
4018447 VANDF
4018824 VANDF
C0031469 UMLSCUI
CHEBI:8093 CHEBI
CHEMBL1215 ChEMBL_ID
DB00388 DRUGBANK_ID
CHEMBL1200339 ChEMBL_ID
CHEMBL2062264 ChEMBL_ID
D010656 MESH_DESCRIPTOR_UI
6041 PUBCHEM_CID
4174 INN_ID
485 IUPHAR_LIGAND_ID
1WS297W6MV UNII
221139 RXNORM
1307 MMSL
30342 MMSL
35410 MMSL
5282 MMSL
5283 MMSL
5284 MMSL
5285 MMSL
d00704 MMSL
001825 NDDF
001826 NDDF
001827 NDDF
001828 NDDF
372771005 SNOMEDCT_US
54765002 SNOMEDCT_US
68699004 SNOMEDCT_US
73946006 SNOMEDCT_US
784324003 SNOMEDCT_US
1WS297W6MV INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fresh Clear HUMAN PRESCRIPTION DRUG LABEL 1 0023-0000 SOLUTION/ DROPS 1.20 mg OPHTHALMIC Export only 1 sections
Childrens Robitussin Cough and Cold CF HUMAN OTC DRUG LABEL 3 0031-8716 LIQUID 2.50 mg ORAL OTC Monograph Drug 17 sections
Robitussin Peak Cold Multi-Symptom Cold HUMAN OTC DRUG LABEL 3 0031-8742 LIQUID 5 mg ORAL OTC Monograph Drug 17 sections
Robitussin Severe Multi-Symptom Cough Cold Flu HUMAN OTC DRUG LABEL 4 0031-8751 LIQUID 10 mg ORAL OTC Monograph Drug 17 sections
Robitussin Severe Multi-Symptom Cough Cold Flu Nighttime HUMAN OTC DRUG LABEL 3 0031-8752 SOLUTION 10 mg ORAL OTC Monograph Drug 17 sections
Phenylephrine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0065-0343 SOLUTION/ DROPS 100 mg OPHTHALMIC NDA 24 sections
Phenylephrine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0065-0349 SOLUTION/ DROPS 25 mg OPHTHALMIC NDA 24 sections
Cyclomydril HUMAN PRESCRIPTION DRUG LABEL 2 0065-0359 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 19 sections
TheraFlu Cold and Flu HUMAN OTC DRUG LABEL 3 0067-0924 POWDER 10 mg ORAL Export only 10 sections
4 WayFast Acting HUMAN OTC DRUG LABEL 1 0067-2086 SPRAY 10 mg NASAL OTC Monograph Drug 15 sections
4 WayFast Acting HUMAN OTC DRUG LABEL 1 0067-2086 SPRAY 10 mg NASAL OTC Monograph Drug 15 sections
Theraflu PowerPods Daytime Severe Cold HUMAN OTC DRUG LABEL 3 0067-6094 POWDER, FOR SOLUTION 10 mg ORAL OTC Monograph Drug 16 sections
THERAFLU POWERPODS NIGHTTIME SEVERE COLD HUMAN OTC DRUG LABEL 3 0067-6095 POWDER, FOR SOLUTION 10 mg ORAL OTC Monograph Drug 16 sections
THERAFLU MULTI-SYMPTOM SEVERE COLD HUMAN OTC DRUG LABEL 3 0067-6426 POWDER, FOR SOLUTION 10 mg ORAL OTC Monograph Drug 17 sections
Theraflu Severe Cold Relief Daytime Berry Burst HUMAN OTC DRUG LABEL 3 0067-6800 POWDER 10 mg ORAL OTC Monograph Drug 17 sections
Theraflu Severe Cold relief Nighttime HUMAN OTC DRUG LABEL 3 0067-6801 POWDER 10 mg ORAL OTC Monograph Drug 17 sections
THERAFLU Severe Cold Relief Daytime HUMAN OTC DRUG LABEL 3 0067-6802 POWDER, FOR SOLUTION 10 mg ORAL OTC Monograph Drug 16 sections
Theraflu Severe Cold Relief Nighttime HUMAN OTC DRUG LABEL 3 0067-6803 POWDER, FOR SOLUTION 10 mg ORAL OTC Monograph Drug 16 sections
Theraflu Daytime Severe Cold and Cough HUMAN OTC DRUG LABEL 3 0067-7917 POWDER, FOR SOLUTION 10 mg ORAL OTC Monograph Drug 16 sections
THERAFLU NIGHTTIME SEVERE COLD AND COUGH HUMAN OTC DRUG LABEL 3 0067-7918 POWDER, FOR SOLUTION 10 mg ORAL OTC Monograph Drug 17 sections
Theraflu ExpressMaxDaytime Severe Cold and Cough HUMAN OTC DRUG LABEL 3 0067-8127 SYRUP 10 mg ORAL OTC Monograph Drug 16 sections
Theraflu ExpressMax Nighttime Severe Cold and Cough HUMAN OTC DRUG LABEL 3 0067-8129 SYRUP 10 mg ORAL OTC Monograph Drug 16 sections
Theraflu ExpressMax Severe Cold and Flu Syrup HUMAN OTC DRUG LABEL 4 0067-8132 SYRUP 10 mg ORAL OTC Monograph Drug 16 sections
TheraFlu Cold and Flu HUMAN OTC DRUG LABEL 3 0067-8135 POWDER 10 mg ORAL Export only 15 sections
Theraflu ExpressMax Daytime Severe Cold and Cough HUMAN OTC DRUG LABEL 3 0067-8136 TABLET, FILM COATED 5 mg ORAL OTC Monograph Drug 16 sections
Theraflu ExpressMax Nighttime Severe Cold and Cough HUMAN OTC DRUG LABEL 3 0067-8137 TABLET, FILM COATED 5 mg ORAL OTC Monograph Drug 16 sections
Theraflu ExpressMax Severe Cold and Flu Caplets HUMAN OTC DRUG LABEL 4 0067-8145 TABLET, COATED 5 mg ORAL OTC Monograph Drug 16 sections
Theraflu Severe Cold Relief Daytime with Honey Ginger Flavor HUMAN OTC DRUG LABEL 3 0067-8211 POWDER, FOR SOLUTION 10 mg ORAL OTC Monograph Drug 17 sections
Theraflu Severe Cold Relief Nighttime with Honey Elderberry Flavor HUMAN OTC DRUG LABEL 3 0067-8212 POWDER, FOR SOLUTION 10 mg ORAL OTC Monograph Drug 17 sections
Good Sense Severe NightTime HUMAN OTC DRUG LABEL 4 0113-0019 SOLUTION 10 mg ORAL OTC Monograph Drug 16 sections