tetryzoline Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihistaminics or local vasoconstrictors, antazoline derivatives 3591 84-22-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tetrahydrozoline nitrate
  • tetrahydrozoline
  • (+/-)-Tetrahydrozoline
  • ocuzolin
  • tetryzolin
  • tetryzoline
  • dl-Tetrahydrozoline
  • tetrahydrozoline hydrochloride
  • tetrahydrozeline hydrochloride
  • tetrahydrozeline nitrate
  • tetrahydrozoline HCl
  • tetrahydrozeline HCl
used as nasal decongestant; Visine is a form of eye drops; RN given refers to parent cpd; structure
  • Molecular weight: 200.29
  • Formula: C13H16N2
  • CLOGP: 3.53
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 24.39
  • ALOGS: -2.92
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.80 mg N

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 30, 1979 FDA FOUGERA PHARMS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC R01AA06 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Sympathomimetics, plain
ATC R01AB03 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Sympathomimetics, combinations excl. corticosteroids
ATC S01GA02 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Sympathomimetics used as decongestants
ATC S01GA52 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Sympathomimetics used as decongestants
CHEBI has role CHEBI:77715 nasal decongestant
CHEBI has role CHEBI:35524 sympathomimetic agent
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014663 Nasal Decongestants
MeSH PA D009883 Ophthalmic Solutions
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019999 Pharmaceutical Solutions
MeSH PA D019141 Respiratory System Agents
MeSH PA D013566 Sympathomimetics
MeSH PA D014662 Vasoconstrictor Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Red eye indication 75705005
Hyperthyroidism contraindication 34486009 DOID:7998
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Diabetes mellitus contraindication 73211009 DOID:9351

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.93 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adrenergic receptor alpha GPCR AGONIST CHEMBL CHEMBL
Adrenergic receptor alpha-2 GPCR IC50 7.52 CHEMBL
Adrenergic receptor alpha GPCR Ki 7.96 CHEMBL
Adrenergic receptor alpha-1 GPCR IC50 5.80 CHEMBL

External reference:

IDSource
4022735 VUID
N0000020740 NUI
C0076286 UMLSCUI
D00756 KEGG_DRUG
0YZT43HS7D UNII
522-48-5 SECONDARY_CAS_RN
372673004 SNOMEDCT_US
2183004 SNOMEDCT_US
4022735 VANDF
004726 NDDF
37935 RXNORM
7784 MMSL
5419 PUBCHEM_CID
CHEBI:28674 CHEBI
CHEMBL1266 ChEMBL_ID
CHEMBL1200413 ChEMBL_ID
519 INN_ID
DB06764 DRUGBANK_ID
C005810 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Walgreens Multi-Symptom Relief Eye Drops HUMAN OTC DRUG LABEL 4 0363-1462 SOLUTION/ DROPS 0.05 g OPHTHALMIC OTC monograph final 8 sections
Walgreens Sterile Original Eye Drops HUMAN OTC DRUG LABEL 1 0363-1676 SOLUTION/ DROPS 0.05 mg OPHTHALMIC OTC monograph final 11 sections
Walgreens Sterile Advance Relief Eye Drops HUMAN OTC DRUG LABEL 3 0363-1677 SOLUTION/ DROPS 0.00 mg OPHTHALMIC OTC monograph final 11 sections
Walgreens Eye Drops Seasonal Relief 15mL HUMAN OTC DRUG LABEL 2 0363-4545 LIQUID 0.05 g OPHTHALMIC OTC monograph final 9 sections
Walgreens Eye Drops Advanced Relief 15mL HUMAN OTC DRUG LABEL 3 0363-4547 LIQUID 0.05 g OPHTHALMIC OTC monograph final 8 sections
Walgreens Eye Drops Original 15mL and twin pack HUMAN OTC DRUG LABEL 1 0363-4550 LIQUID 0.05 g OPHTHALMIC OTC monograph final 8 sections
Walgreens Sterile Original Eye HUMAN OTC DRUG LABEL 1 0363-7298 SOLUTION/ DROPS 0.50 mg OPHTHALMIC OTC monograph final 11 sections
Eye Drops HUMAN OTC DRUG LABEL 1 0498-0161 SOLUTION/ DROPS 0.05 g OPHTHALMIC OTC monograph final 8 sections
Industrial Strength Eye Drops HUMAN OTC DRUG LABEL 2 0498-0162 SOLUTION/ DROPS 0.05 g OPHTHALMIC OTC monograph final 9 sections
4248 First Aid Kit HUMAN OTC DRUG LABEL 22 0498-4248 KIT 0.05 g None unapproved drug other 9 sections
Rugby Eye HUMAN OTC DRUG LABEL 1 0536-1002 SOLUTION/ DROPS 0.05 mg OPHTHALMIC OTC monograph final 12 sections
Rugby Tetrahydrozoline Ophthalmic Solution HUMAN OTC DRUG LABEL 1 0536-1217 SOLUTION/ DROPS 0.05 g OPHTHALMIC OTC monograph final 9 sections
Major Redness Reliever Eye HUMAN OTC DRUG LABEL 1 0904-6334 SOLUTION/ DROPS 0.50 mg OPHTHALMIC OTC monograph final 11 sections
Rohto HUMAN OTC DRUG LABEL 1 10742-8143 LIQUID 0.50 mg OPHTHALMIC OTC monograph final 8 sections
Rohto Digi-Eye HUMAN OTC DRUG LABEL 1 10742-8175 LIQUID 0.50 mg OPHTHALMIC OTC monograph final 8 sections
Up and Up Ultra Itchy Relief HUMAN OTC DRUG LABEL 2 11673-672 SOLUTION/ DROPS 0.50 mg OPHTHALMIC OTC monograph final 12 sections
GOODSENSE ORIGINAL EYE DROPS HUMAN OTC DRUG LABEL 1 11716-0002 SOLUTION 0.50 mg OPHTHALMIC OTC monograph final 11 sections
GOODSENSE IRRITATION RELIEF EYE HUMAN OTC DRUG LABEL 2 11716-0003 SOLUTION/ DROPS 0.50 mg OPHTHALMIC OTC monograph final 11 sections
GOODSENSE ADVANCED RELIEF EYE HUMAN OTC DRUG LABEL 3 11716-0004 SOLUTION/ DROPS 0.50 mg OPHTHALMIC OTC monograph final 11 sections
DG HEALTH ORIGINAL HUMAN OTC DRUG LABEL 1 11716-0053 SOLUTION 0.50 mg OPHTHALMIC OTC monograph final 11 sections
PREMIER VALUE ORIGINAL HUMAN OTC DRUG LABEL 1 11716-0101 SOLUTION 0.50 mg OPHTHALMIC OTC monograph final 12 sections
PREMIER VALUE ADVANCED EYE DROPS HUMAN OTC DRUG LABEL 3 11716-0102 SOLUTION 0.00 mL OPHTHALMIC OTC monograph final 11 sections
PREMIER VALUE EYE AC HUMAN OTC DRUG LABEL 2 11716-0103 SOLUTION 0.50 mg OPHTHALMIC OTC monograph final 11 sections
SHOPKO ADVANCED FORMULA EYE DROPS HUMAN OTC DRUG LABEL 3 11716-0458 SOLUTION 0.00 mL OPHTHALMIC OTC monograph final 11 sections
SHOPKO RELIEF HUMAN OTC DRUG LABEL 2 11716-0460 SOLUTION 0.50 mg OPHTHALMIC OTC monograph final 11 sections
LEADER ADVANCED FORMULA EYE DROPS HUMAN OTC DRUG LABEL 3 11716-1104 SOLUTION 0.00 mL OPHTHALMIC OTC monograph final 11 sections
WALGREENS MAXIMUM RELIEF EYE DROPS HUMAN OTC DRUG LABEL 3 11716-1167 SOLUTION 0.00 mL OPHTHALMIC OTC monograph final 11 sections
WALGREENS ORIGINAL EYE DROPS HUMAN OTC DRUG LABEL 1 11716-1168 SOLUTION 0.50 mg OPHTHALMIC OTC monograph final 11 sections
FREDS ORIGINAL EYE DROPS HUMAN OTC DRUG LABEL 1 11716-1187 SOLUTION 0.50 mg OPHTHALMIC OTC monograph final 11 sections
SHOPKO ORIGINAL FORMULA EYE DROPS HUMAN OTC DRUG LABEL 1 11716-1609 SOLUTION 0.50 mg OPHTHALMIC OTC monograph final 11 sections