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xylometazoline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antihistaminics or local vasoconstrictors, antazoline derivatives	3658	526-36-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: xylometazoline rhinoxilin otrivine xylometazoline hydrochloride xylometazoline HCl	nasal decongestant Molecular weight: 244.38 Formula: C16H24N2 CLOGP: 5.38 LIPINSKI: 1 HAC: 2 HDO: 1 TPSA: 24.39 ALOGS: -4.44 ROTB: 3

Molecule

Description

Molfile Inchi Smiles

Synonyms:

xylometazoline
rhinoxilin
otrivine
xylometazoline hydrochloride
xylometazoline HCl

nasal decongestant

Molecular weight: 244.38
Formula: C16H24N2
CLOGP: 5.38
LIPINSKI: 1
HAC: 2
HDO: 1
TPSA: 24.39
ALOGS: -4.44
ROTB: 3

Drug dosage:

Dose	Unit	Route
0.80	mg	N

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Reversible cerebral vasoconstriction syndrome	141.94	27.76	26	961	2632	63485403
Thunderclap headache	101.86	27.76	14	973	217	63487818
Rebound nasal congestion	89.78	27.76	10	977	20	63488015
Subarachnoid haemorrhage	48.53	27.76	15	972	14268	63473767
Nasal mucosal disorder	41.10	27.76	7	980	462	63487573
Cerebral artery stenosis	40.94	27.76	7	980	473	63487562
Anticholinergic syndrome	40.52	27.76	9	978	2373	63485662
Nasal turbinate hypertrophy	37.70	27.76	7	980	756	63487279
Nasal septum deviation	32.81	27.76	7	980	1529	63486506
Allergy to animal	28.45	27.76	6	981	1240	63486795

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	280.89	74.56	74	2469	8527	34945861
Appendicitis	241.13	74.56	74	2469	14733	34939655
Blood phosphorus increased	240.45	74.56	64	2479	7657	34946731
Cardiogenic shock	202.25	74.56	75	2468	26543	34927845
Stress	196.24	74.56	76	2467	30271	34924117
Ventricular fibrillation	182.88	74.56	67	2476	22887	34931501
Ascites	180.70	74.56	81	2462	46490	34907898
Abdominal distension	151.28	74.56	77	2466	58415	34895973
Dry mouth	148.06	74.56	62	2481	30103	34924285
Multiple organ dysfunction syndrome	129.17	74.56	76	2467	76490	34877898

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	320.47	38.55	74	3320	8477	79732517
Blood phosphorus increased	255.70	38.55	64	3330	10283	79730711
Appendicitis	255.22	38.55	74	3320	20720	79720274
Cardiogenic shock	207.98	38.55	75	3319	41839	79699155
Ventricular fibrillation	196.17	38.55	67	3327	31859	79709135
Ascites	184.45	38.55	81	3313	75481	79665513
Stress	164.56	38.55	76	3318	79536	79661458
Abdominal distension	146.27	38.55	80	3314	119570	79621424
Reversible cerebral vasoconstriction syndrome	138.95	38.55	31	3363	3026	79737968
Multiple organ dysfunction syndrome	132.20	38.55	75	3319	120171	79620823

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	R01AA07	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Sympathomimetics, plain
ATC	R01AB06	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Sympathomimetics, combinations excl. corticosteroids
ATC	S01GA03	SENSORY ORGANS OPHTHALMOLOGICALS DECONGESTANTS AND ANTIALLERGICS Sympathomimetics used as decongestants
ATC	S01GA53	SENSORY ORGANS OPHTHALMOLOGICALS DECONGESTANTS AND ANTIALLERGICS Sympathomimetics used as decongestants
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D014663	Nasal Decongestants
MeSH PA	D019141	Respiratory System Agents
MeSH PA	D014662	Vasoconstrictor Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Heart disease	contraindication	56265001	DOID:114
Diabetes mellitus	contraindication	73211009	DOID:9351
Transsphenoidal hypophysectomy	contraindication	171948002

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.95	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN	AGONIST	Ki	5.98	PDSP	SCIENTIFIC LITERATURE
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		Ki	7.04	CHEMBL
5-hydroxytryptamine receptor 1B	GPCR	P28222	5HT1B_HUMAN		Ki	7.89	CHEMBL
5-hydroxytryptamine receptor 1D	GPCR	P28221	5HT1D_HUMAN		Ki	9.15	CHEMBL
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	7.82	PDSP
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	6.89	PDSP
Adrenergic receptor alpha-2	GPCR		ADA2B_RAT ADA2C_RAT ADA2A_RAT		IC50	7.64	CHEMBL
Adrenergic receptor alpha-1	GPCR		ADA1B_RAT ADA1D_RAT ADA1A_RAT		IC50	6.24	CHEMBL
Adrenergic receptor alpha	GPCR		ADA1B_RAT ADA2B_RAT ADA2C_RAT ADA2A_RAT ADA1D_RAT ADA1A_RAT		Ki	8.32	CHEMBL

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External reference:

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ID	Source
001804	NDDF
004727	NDDF
1218-35-5	SECONDARY_CAS_RN
12647	MMSL
226046	RXNORM
372841007	SNOMEDCT_US
4020500	VANDF
4020518	VUID
4020518	VANDF
517	IUPHAR_LIGAND_ID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Aqua Maris Fast Acting Decongestant	HUMAN OTC DRUG LABEL	1	76260-106	SPRAY	10 mg	NASAL	OTC monograph final	13 sections
Aqua Maris Kids Fast Acting Decongestant	HUMAN OTC DRUG LABEL	1	76260-107	SPRAY	0.05 mg	NASAL	OTC monograph final	12 sections
Metarivin Soln. 0.1%	HUMAN OTC DRUG LABEL	1	72988-0030	LIQUID	1 mg	NASAL	unapproved drug other	7 sections
SinosilNasal Decongestant	HUMAN OTC DRUG LABEL	1	44237-007	SPRAY	0.02 mL	NASAL	OTC monograph final	14 sections

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