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naphazoline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antihistaminics or local vasoconstrictors, antazoline derivatives	3369	835-31-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: naphazoline nitrate naphazoline naphthazoline naphthizine nephazoline rhinazine naphazoline hydrochloride naphazoline HCl	An adrenergic vasoconstrictor agent used as a decongestant. Molecular weight: 210.28 Formula: C14H14N2 CLOGP: 3.83 LIPINSKI: 0 HAC: 2 HDO: 1 TPSA: 24.39 ALOGS: -3.74 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

naphazoline nitrate
naphazoline
naphthazoline
naphthizine
nephazoline
rhinazine
naphazoline hydrochloride
naphazoline HCl

An adrenergic vasoconstrictor agent used as a decongestant.

Molecular weight: 210.28
Formula: C14H14N2
CLOGP: 3.83
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 24.39
ALOGS: -3.74
ROTB: 2

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.40	mg	N

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
June 7, 1971	FDA	NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	R01AA08	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Sympathomimetics, plain
ATC	R01AB02	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Sympathomimetics, combinations excl. corticosteroids
ATC	S01GA01	SENSORY ORGANS OPHTHALMOLOGICALS DECONGESTANTS AND ANTIALLERGICS Sympathomimetics used as decongestants
ATC	S01GA51	SENSORY ORGANS OPHTHALMOLOGICALS DECONGESTANTS AND ANTIALLERGICS Sympathomimetics used as decongestants
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D000322	Adrenergic Agonists
MeSH PA	D000316	Adrenergic alpha-Agonists
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D014663	Nasal Decongestants
MeSH PA	D018377	Neurotransmitter Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Red eye	indication	75705005
Ocular Itching	indication
Hyperthyroidism	contraindication	34486009	DOID:7998
Hypertensive disorder	contraindication	38341003	DOID:10763
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Diabetes mellitus	contraindication	73211009	DOID:9351
Hyperglycemia	contraindication	80394007	DOID:4195
Eye infection	contraindication	128351009
Injury of eye region	contraindication	282752000
Angle-closure glaucoma	contraindication	392291006	DOID:13550

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.3	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN	AGONIST	Ki	7.68	PDSP	CHEMBL
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN	AGONIST	Ki	6.39	PDSP	CHEMBL
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN	AGONIST	Ki	6.39	PDSP	CHEMBL
Nischarin	Membrane receptor	Q9Y2I1	NISCH_HUMAN		Ki	6.92	CHEMBL
Nischarin	Unclassified		NISCH_RAT		Ki	6.61	CHEMBL
Adrenergic receptor alpha-2	GPCR		ADA2B_RAT ADA2C_RAT ADA2A_RAT		Ki	8.24	CHEMBL
Adrenergic receptor alpha-1	GPCR		ADA1B_RAT ADA1D_RAT ADA1A_RAT		EC50	7.92	CHEMBL
Adrenergic receptor alpha	GPCR		ADA1B_RAT ADA2B_RAT ADA2C_RAT ADA2A_RAT ADA1D_RAT ADA1A_RAT		Ki	8.24	CHEMBL

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External reference:

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ID	Source
001802	NDDF
003876	NDDF
003877	NDDF
2098	MMSL
235810	RXNORM
372803000	SNOMEDCT_US
4018585	VANDF
4019855	VANDF
4153	INN_ID
4436	PUBCHEM_CID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
7 Select Redness Relief	HUMAN OTC DRUG LABEL	2	10202-850	SOLUTION/ DROPS	0 mg	OPHTHALMIC	OTC monograph final	14 sections
7 Select Redness Relief	HUMAN OTC DRUG LABEL	2	10202-850	SOLUTION/ DROPS	0 mg	OPHTHALMIC	OTC monograph final	14 sections
Eye Allergy Relief	HUMAN OTC DRUG LABEL	2	0363-0430	SOLUTION/ DROPS	0.27 mg	OPHTHALMIC	NDA	14 sections
Eye Allergy Relief	HUMAN OTC DRUG LABEL	2	0363-0430	SOLUTION/ DROPS	0.27 mg	OPHTHALMIC	NDA	14 sections
Eye Allergy Relief	HUMAN OTC DRUG LABEL	2	11673-430	SOLUTION/ DROPS	0.27 mg	OPHTHALMIC	NDA	14 sections
Eye Allergy Relief	HUMAN OTC DRUG LABEL	2	11673-430	SOLUTION/ DROPS	0.27 mg	OPHTHALMIC	NDA	14 sections
Eye Allergy Relief	HUMAN OTC DRUG LABEL	2	11822-0552	SOLUTION/ DROPS	0.27 mg	OPHTHALMIC	NDA	14 sections
Lubricant / Redness Reliever	HUMAN OTC DRUG LABEL	2	11822-3025	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC monograph final	14 sections
Naphcon A	HUMAN OTC DRUG LABEL	2	0065-0085	SOLUTION/ DROPS	0.25 mg	OPHTHALMIC	NDA	14 sections
Naphcon A	HUMAN OTC DRUG LABEL	2	0065-0085	SOLUTION/ DROPS	0.25 mg	OPHTHALMIC	NDA	14 sections

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