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metizoline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antihistaminics or local vasoconstrictors, antazoline derivatives | 4671 | 17692-22-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,MAP3K1,MAP3K21,MAP3K7,MAPK10,MAPK7,MARK4,MET,NTRK2,PDK1,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,STK33,TEK,TTK | 32 | |||
| kinase-selectivity-class | AXL | 1 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R01AA10 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Sympathomimetics, plain |
| CHEBI has role | CHEBI:24527 | herbicide |
| CHEBI has role | CHEBI:26841 | synthetic auxin |
| CHEBI has role | CHEBI:77715 | nasal decongestant |
Related Drugs by ATC class:
R01AA Sympathomimetics, plain 13 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Nasal congestion | indication | 68235000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.44 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Nischarin | Membrane receptor | Ki | 9.20 | CHEMBL | |||||
| Alpha-ketoglutarate-dependent dioxygenase FTO | Enzyme | IC50 | 5.86 | CHEMBL | |||||
| Amine oxidase [flavin-containing] B | Enzyme | Ki | 5.83 | CHEMBL | |||||
| Amine oxidase [flavin-containing] A | Enzyme | Ki | 4.86 | CHEMBL | |||||
| Nischarin | Membrane receptor | Ki | 8.89 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D05006 | KEGG_DRUG |
| CHEBI:136017 | CHEBI |
| CHEMBL1370446 | ChEMBL_ID |
| CHEMBL266155 | ChEMBL_ID |
| CHEMBL2106879 | ChEMBL_ID |
| C010242 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2380 | INN_ID |
| 3813-05-6 | SECONDARY_CAS_RN |
| 5090-37-9 | SECONDARY_CAS_RN |
| DB13614 | DRUGBANK_ID |
| Z27L8N105U | UNII |
| C0604284 | UMLSCUI |
| 28688 | PUBCHEM_CID |
Pharmaceutical products:
None