metizoline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihistaminics or local vasoconstrictors, antazoline derivatives 4671 17692-22-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metizoline monohydrochloride
  • metizoline
  • benazolin
  • benazoline
  • metizolin
  • metizoline hydrochloride
  • metizoline HCl
  • Molecular weight: 230.33
  • Formula: C13H14N2S
  • CLOGP: 4.13
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 24.39
  • ALOGS: -4
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R01AA10 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Sympathomimetics, plain
CHEBI has role CHEBI:24527 herbicides
CHEBI has role CHEBI:26841 synthetic auxins

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Nasal congestion indication 68235000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.44 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Nischarin Membrane receptor Ki 9.20 CHEMBL
Amine oxidase [flavin-containing] B Enzyme Ki 5.83 CHEMBL
Amine oxidase [flavin-containing] A Enzyme Ki 4.86 CHEMBL
Nischarin Unclassified Ki 8.89 CHEMBL

External reference:

IDSource
D05006 KEGG_DRUG
3813-05-6 SECONDARY_CAS_RN
5090-37-9 SECONDARY_CAS_RN
CHEBI:136017 CHEBI
CHEMBL1370446 ChEMBL_ID
C010242 MESH_SUPPLEMENTAL_RECORD_UI
2380 INN_ID
DB13614 DRUGBANK_ID
Z27L8N105U UNII
C0604284 UMLSCUI
CHEMBL266155 ChEMBL_ID
CHEMBL2106879 ChEMBL_ID
28688 PUBCHEM_CID

Pharmaceutical products:

None