tuaminoheptane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3637 123-82-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tuamine sulfate
  • tuamine
  • tuaminoheptane sulfate
  • tuaminoheptane
  • heptamine
  • heptin
  • rineptil
  • rineptyl
  • tuaminoheptan
an adrenergic agent used as a nasal decongestant in the form of the base (for inhalation) or the sulfate salt (topical solution)
  • Molecular weight: 115.22
  • Formula: C7H17N
  • CLOGP: 2.29
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 26.02
  • ALOGS: -1.54
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,IKBKB,IRAK4,ITK,JAK3,MAP2K6,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 36
kinase-selectivity-class AKT2,AXL,CAMK2D,CDK4,EIF2AK3,PDK4 6
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R01AA11 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Sympathomimetics, plain
ATC R01AB08 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Sympathomimetics, combinations excl. corticosteroids
CHEBI has role CHEBI:77715 nasal decongestant

Related Drugs by ATC class:

R01AA Sympathomimetics, plain 13 drugs
cyclopentamineephedrineepinephrinefenoxazolineindanazolinemetizolinenaphazolineoxymetazolinephenylephrinetetryzolinetramazolinetymazoline show all 13 →
R01AB Sympathomimetics, combinations excl. corticosteroids 6 drugs
ephedrinenaphazolineoxymetazolinephenylephrinetetryzolinexylometazoline

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.51 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
Z0420GYD84 UNII
D07371 KEGG_DRUG
6411-75-2 SECONDARY_CAS_RN
C0642440 UMLSCUI
CHEBI:134753 CHEBI
CHEMBL123693 ChEMBL_ID
5603 PUBCHEM_CID
DB13238 DRUGBANK_ID
CHEMBL3560769 ChEMBL_ID
140 INN_ID
C065369 MESH_SUPPLEMENTAL_RECORD_UI
001806 NDDF
001808 NDDF
15810003 SNOMEDCT_US
708563000 SNOMEDCT_US

Pharmaceutical products:

None