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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
sympathomimetics	2326	90-82-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: pseudoephedrine (+)-Pseudoephedrine pseudophedrine sulphate pseudoephedrine hydrochloride pseudoephedrine sulfate pseudoephedrine HCl pseudoephedrine polistirex	A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion. Molecular weight: 165.24 Formula: C10H15NO CLOGP: 0.89 LIPINSKI: 0 HAC: 2 HDO: 2 TPSA: 32.26 ALOGS: -1.30 ROTB: 3 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

pseudoephedrine
(+)-Pseudoephedrine
pseudophedrine sulphate
pseudoephedrine hydrochloride
pseudoephedrine sulfate
pseudoephedrine HCl
pseudoephedrine polistirex

A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.

Molecular weight: 165.24
Formula: C10H15NO
CLOGP: 0.89
LIPINSKI: 0
HAC: 2
HDO: 2
TPSA: 32.26
ALOGS: -1.30
ROTB: 3

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.24	g	O
0.24	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	43 %	Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability)	100 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value
kinase-safety-class	ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK3,MAP3K21,MAP3K7,MAPK7,NTRK2,PDK2,PDK4,PIM2,PRKDC,SIK2,SIK3,SYK,TEK,TGFBR1,ZAP70	33
kinase-selectivity-class	AXL,EIF2AK3,GRK2,PDK4	4
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
Oct. 18, 1963	FDA	SCHERING PLOUGH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	3055.38	21.79	4883	340234	321981	89961349
Systemic lupus erythematosus	2911.33	21.79	5054	340063	356842	89926488
Glossodynia	2732.32	21.79	4604	340513	317175	89966155
Wound	2715.69	21.79	4442	340675	298538	89984792
Pericarditis	2703.72	21.79	4166	340951	265985	90017345
Hand deformity	2692.81	21.79	4372	340745	291990	89991340
Anti-cyclic citrullinated peptide antibody positive	2251.62	21.79	3565	341552	232868	90050462
Synovitis	2116.30	21.79	4181	340936	325571	89957759
Duodenal ulcer perforation	2001.64	21.79	3260	341857	218028	90065302
Discomfort	1925.65	21.79	3614	341503	270721	90012609
Helicobacter infection	1889.92	21.79	3221	341896	223629	90059701
Swelling	1822.66	21.79	4547	340570	414511	89868819
Arthropathy	1809.77	21.79	4176	340941	362066	89921264
Abdominal discomfort	1779.76	21.79	4889	340228	472439	89810891
Alopecia	1580.70	21.79	4797	340320	490274	89793056
Hepatic enzyme increased	1451.84	21.79	3803	341314	356933	89926397
Folliculitis	1392.79	21.79	2660	342457	201693	90081637
Rheumatoid factor positive	1384.87	21.79	2404	342713	169246	90114084
Infusion related reaction	1357.98	21.79	4069	341048	412711	89870619
Rheumatic fever	1343.00	21.79	2226	342891	150895	90132435
Contraindicated product administered	1304.00	21.79	3391	341726	316748	89966582
Irritable bowel syndrome	1292.04	21.79	2600	342517	204848	90078482
Muscle injury	1228.84	21.79	2320	342797	174334	90108996
Type 2 diabetes mellitus	1179.12	21.79	2474	342643	200770	90082560
Blister	1156.06	21.79	2814	342303	252184	90031146
Maternal exposure during pregnancy	1087.74	21.79	3425	341692	356638	89926692
Swollen joint count increased	1070.58	21.79	1687	343430	109519	90173811
Impaired healing	1052.35	21.79	2576	342541	231623	90051707
Hypersensitivity	1043.95	21.79	3947	341170	450730	89832600
Sleep disorder due to general medical condition, insomnia type	1033.04	21.79	1799	343318	126895	90156435
Acute kidney injury	960.55	21.79	67	345050	320320	89963010
Anaemia	945.54	21.79	116	345001	352686	89930644
Blood cholesterol increased	907.82	21.79	2263	342854	205749	90077581
Joint swelling	901.81	21.79	4048	341069	499252	89784078
Drug interaction	880.16	21.79	41	345076	276412	90006918
Psoriatic arthropathy	862.16	21.79	2353	342764	225982	90057348
Therapeutic product effect decreased	817.01	21.79	2618	342499	274953	90008377
Injury	800.81	21.79	2089	343028	195260	90088070
Stomatitis	798.60	21.79	2580	342537	272118	90011212
Liver injury	793.35	21.79	1902	343215	168665	90114665
Ill-defined disorder	782.02	21.79	1988	343129	182903	90100427
Hypotension	761.55	21.79	156	344961	325241	89958089
Product use issue	748.64	21.79	2855	342262	327064	89956266
Drug intolerance	731.11	21.79	3505	341612	444086	89839244
Toxicity to various agents	712.07	21.79	120	344997	287726	89995604
Fall	705.77	21.79	486	344631	481324	89802006
Death	692.32	21.79	443	344674	456108	89827222
Neutropenia	688.77	21.79	42	345075	224862	90058468
Lower respiratory tract infection	673.73	21.79	2293	342824	248366	90034964
Fibromyalgia	633.54	21.79	1975	343142	204294	90079036
Cough	625.26	21.79	312	344805	368650	89914680
Urinary tract infection	604.22	21.79	205	344912	305427	89977903
General physical health deterioration	603.52	21.79	2814	342303	352301	89931029
Treatment failure	576.85	21.79	2489	342628	301439	89981891
Nausea	570.24	21.79	2241	342876	1108075	89175255
Constipation	559.59	21.79	185	344932	280210	90003120
Back pain	555.98	21.79	256	344861	316919	89966411
Joint range of motion decreased	545.94	21.79	1432	343685	134211	90149119
Facet joint syndrome	531.05	21.79	1164	343953	97225	90186105
Lip dry	523.10	21.79	1175	343942	99780	90183550
Somnolence	519.54	21.79	86	345031	208998	90074332
Erythema	515.67	21.79	120	344997	229126	90054204
Product dose omission issue	513.42	21.79	234	344883	291453	89991877
Febrile neutropenia	498.91	21.79	25	345092	158324	90125006
Mobility decreased	490.71	21.79	2073	343044	248661	90034669
Gastrointestinal disorder	485.99	21.79	2101	343016	254586	90028744
Sepsis	484.13	21.79	58	345059	179756	90103574
Musculoskeletal stiffness	475.30	21.79	2311	342806	294221	89989109
Disease progression	474.20	21.79	31	345086	156584	90126746
Dehydration	457.21	21.79	92	345025	194355	90088975
Peripheral venous disease	450.77	21.79	991	344126	82930	90200400
Deep vein thrombosis postoperative	425.16	21.79	875	344242	69934	90213396
Pancytopenia	406.24	21.79	11	345106	120252	90163078
Hyponatraemia	405.55	21.79	26	345091	133512	90149818
Wound infection	402.48	21.79	1098	344019	105304	90178026
Injection site pain	394.41	21.79	89	345028	173610	90109720
Intentional product use issue	388.16	21.79	1746	343371	215146	90068184
Haemoglobin decreased	384.14	21.79	75	345042	161881	90121449
Diarrhoea	377.31	21.79	2071	343046	937119	89346211
White blood cell count decreased	376.68	21.79	87	345030	167022	90116308
Thrombocytopenia	374.16	21.79	163	344954	208562	90074768
Hip arthroplasty	372.58	21.79	867	344250	75341	90207989
Blood pressure increased	369.71	21.79	144	344973	197073	90086257
Sleep disorder	364.76	21.79	1608	343509	196422	90086908
Platelet count decreased	361.80	21.79	47	345070	136922	90146408
Renal failure	358.25	21.79	40	345077	130967	90152363
Contusion	355.50	21.79	1891	343226	249325	90034005
Seizure	353.02	21.79	75	345042	152554	90130776
Hyperhidrosis	345.44	21.79	53	345064	136252	90147078
Tremor	344.72	21.79	80	345037	153093	90130237
Breast cancer stage III	342.14	21.79	894	344223	83553	90199777
Sinusitis	338.87	21.79	2352	342765	340736	89942594
Grip strength decreased	338.86	21.79	944	344173	91632	90191698
Autoimmune disorder	338.50	21.79	839	344278	75905	90207425
Road traffic accident	335.14	21.79	1036	344081	106590	90176740
Hypercholesterolaemia	329.91	21.79	988	344129	99904	90183426
Rash	328.77	21.79	4541	340576	791559	89491771
Malignant neoplasm progression	326.92	21.79	20	345097	106850	90176480
Syncope	326.30	21.79	56	345061	132607	90150723
C-reactive protein abnormal	325.58	21.79	1147	343970	126282	90157048
Myalgia	324.74	21.79	130	344987	174995	90108335
Renal impairment	324.70	21.79	19	345098	105402	90177928
Cardiac failure	324.67	21.79	24	345093	109472	90173858
Atrial fibrillation	322.97	21.79	59	345058	133552	90149778
Confusional state	320.85	21.79	2541	342576	383664	89899666
Infection	320.01	21.79	2417	342700	359677	89923653
Obesity	316.90	21.79	1003	344114	104504	90178826
Sciatica	311.13	21.79	971	344146	100411	90182919
Bursitis	310.89	21.79	1155	343962	130499	90152831
Alanine aminotransferase increased	306.85	21.79	43	345074	118295	90165035
Completed suicide	306.75	21.79	86	345031	144972	90138358
Neuropathy peripheral	303.37	21.79	74	345043	136896	90146434
Wheezing	298.70	21.79	1735	343382	236345	90046985
Dislocation of vertebra	296.06	21.79	657	344460	55311	90228019
Pulmonary fibrosis	295.88	21.79	992	344125	106511	90176819
Weight increased	292.28	21.79	2646	342471	415281	89868049
Lower limb fracture	291.76	21.79	847	344270	84166	90199164
Nasopharyngitis	291.11	21.79	2590	342527	404514	89878816
Gait inability	289.41	21.79	1215	343902	145241	90138089
Cerebrovascular accident	289.18	21.79	59	345058	123474	90159856
Live birth	288.85	21.79	806	344311	78301	90205029
Adjustment disorder with depressed mood	288.78	21.79	656	344461	56097	90227233
Night sweats	286.96	21.79	1109	344008	127657	90155673
Blood creatinine increased	282.19	21.79	29	345088	101357	90181973
Knee arthroplasty	281.86	21.79	825	344292	82357	90200973
Chest discomfort	279.90	21.79	89	345028	138276	90145054
COVID-19	277.92	21.79	148	344969	168695	90114635
Inappropriate schedule of product administration	275.21	21.79	113	345004	149820	90133510
Feeling abnormal	271.75	21.79	149	344968	167086	90116244
Aspartate aminotransferase increased	270.22	21.79	36	345081	102901	90180429
Oxygen saturation decreased	269.61	21.79	43	345074	107440	90175890
Influenza	267.12	21.79	98	345019	139166	90144164
Respiratory failure	266.14	21.79	62	345055	118356	90164974
Blepharospasm	264.66	21.79	625	344492	54820	90228510
X-ray abnormal	264.05	21.79	554	344563	44870	90238460
Intentional overdose	263.35	21.79	26	345091	93808	90189522
Prescribed overdose	259.97	21.79	891	344226	96734	90186596
Bradycardia	258.56	21.79	15	345102	83832	90199498
Heart rate increased	257.96	21.79	57	345060	112845	90170485
Myocardial infarction	257.84	21.79	46	345071	105926	90177404
Adverse event	256.52	21.79	1005	344112	116413	90166917
Herpes zoster	255.99	21.79	30	345087	94614	90188716
Pain	255.94	21.79	5261	339856	991080	89292250
Balance disorder	254.71	21.79	34	345083	97046	90186284
Blood glucose increased	253.17	21.79	32	345085	95214	90188116
Lupus vulgaris	250.88	21.79	540	344577	44519	90238811
Dry mouth	247.04	21.79	1366	343751	182693	90100637
Onychomadesis	246.71	21.79	543	344574	45455	90237875
Palpitations	244.61	21.79	107	345010	136621	90146709
Injection site erythema	239.12	21.79	43	345074	98459	90184871
Vision blurred	237.67	21.79	63	345054	110230	90173100
Pulmonary embolism	234.63	21.79	102	345015	130718	90152612
Cardiac arrest	233.72	21.79	56	345061	104879	90178451
Chills	233.41	21.79	105	345012	131876	90151454
Multiple organ dysfunction syndrome	231.70	21.79	6	345111	68330	90215000
Prescribed underdose	231.51	21.79	720	344397	74299	90209031
Retinitis	229.33	21.79	474	344643	37984	90245346
Electrocardiogram QT prolonged	223.30	21.79	13	345104	72443	90210887
Hyperkalaemia	222.96	21.79	5	345112	64959	90218371
Oropharyngeal pain	222.69	21.79	80	345037	115107	90168223
Gastrointestinal haemorrhage	222.12	21.79	38	345079	90210	90193120
Hypoglycaemia	220.04	21.79	11	345106	69837	90213493
Osteoarthritis	218.47	21.79	1384	343733	194346	90088984
Hypoaesthesia	214.70	21.79	1980	343137	312230	89971100
Suicide attempt	213.94	21.79	20	345097	75379	90207951
Depressed level of consciousness	212.81	21.79	17	345100	72767	90210563
Drug abuse	210.96	21.79	31	345086	82316	90201014
Dysphagia	205.42	21.79	85	345032	112193	90171137
Peripheral swelling	204.78	21.79	2439	342678	410667	89872663
Lung disorder	204.18	21.79	1117	344000	148766	90134564
Flushing	203.53	21.79	44	345073	88447	90194883
Neutrophil count decreased	200.26	21.79	20	345097	71512	90211818
Coma	198.99	21.79	22	345095	72610	90210720
Anti-cyclic citrullinated peptide antibody	195.70	21.79	363	344754	26858	90256472
Blood pressure decreased	194.65	21.79	27	345090	74868	90208462
Blood pressure systolic increased	194.58	21.79	6	345111	58339	90224991
Hypokalaemia	193.21	21.79	131	344986	130985	90152345
Leukopenia	192.90	21.79	71	345046	100639	90182691
Angioedema	190.11	21.79	15	345102	64861	90218469
Nail disorder	187.92	21.79	573	344544	58494	90224836
Rheumatoid arthritis	187.24	21.79	2158	342959	360456	89922874
Cellulitis	186.05	21.79	58	345059	91279	90192051
Mucosal inflammation	185.01	21.79	8	345109	57617	90225713
Onychomycosis	184.57	21.79	427	344690	36949	90246381
Wrong technique in product usage process	180.92	21.79	28	345089	71543	90211787
Urticaria	179.67	21.79	1901	343216	310833	89972497
Vertigo	179.48	21.79	26	345091	69785	90213545
Pleural effusion	175.86	21.79	104	345013	111887	90171443
C-reactive protein	175.86	21.79	377	344740	30990	90252340
Epistaxis	173.48	21.79	54	345063	85071	90198259
Abdominal pain	173.16	21.79	846	344271	394875	89888455
Skin exfoliation	172.97	21.79	26	345091	67887	90215443
Dyspnoea exertional	172.36	21.79	33	345084	72255	90211075
Dry skin	172.24	21.79	60	345057	88013	90195317
Incorrect dose administered	172.12	21.79	44	345073	78886	90204444
Abortion spontaneous	171.92	21.79	8	345109	54048	90229282
Rhabdomyolysis	171.92	21.79	5	345112	51251	90232079
Inflammation	171.71	21.79	1217	343900	177375	90105955
Metabolic acidosis	171.54	21.79	10	345107	55666	90227664
Oedema	169.38	21.79	1324	343793	198971	90084359
Lactic acidosis	168.97	21.79	5	345112	50458	90232872
Loss of consciousness	167.35	21.79	172	344945	140066	90143264
Suicidal ideation	167.27	21.79	38	345079	73817	90209513
Influenza like illness	166.33	21.79	50	345067	80561	90202769
Interstitial lung disease	165.83	21.79	43	345074	76362	90206968
Taste disorder	165.81	21.79	564	344553	60982	90222348
Cystitis	164.39	21.79	28	345089	66690	90216640
Swelling face	163.31	21.79	53	345064	81299	90202031
Stress	161.69	21.79	54	345063	81341	90201989
Cardiac failure congestive	161.65	21.79	87	345030	98607	90184723
Exostosis	159.36	21.79	505	344612	52629	90230701
Cognitive disorder	158.62	21.79	35	345082	69372	90213958
Overdose	156.84	21.79	223	344894	157486	90125844
Cataract	155.65	21.79	41	345076	72051	90211279
Lupus-like syndrome	155.52	21.79	474	344643	48372	90234958
Heart rate decreased	152.31	21.79	14	345103	53491	90229839
Laryngitis	150.96	21.79	481	344636	50272	90233058
Thrombosis	150.11	21.79	46	345071	73205	90210125
Off label use	150.04	21.79	3132	341985	1099120	89184210
Deep vein thrombosis	149.71	21.79	81	345036	91539	90191791
Cardio-respiratory arrest	148.07	21.79	30	345087	63110	90220220
Sedation	147.35	21.79	9	345108	48162	90235168
Agitation	147.08	21.79	37	345080	67061	90216269
Hepatic function abnormal	146.73	21.79	7	345110	46281	90237049
Blood bilirubin increased	146.68	21.79	4	345113	43466	90239864
Blood pressure fluctuation	145.82	21.79	15	345102	52398	90230932
Bone erosion	145.58	21.79	489	344628	52532	90230798
Lethargy	143.96	21.79	32	345085	63107	90220223
Dysarthria	140.74	21.79	20	345097	54462	90228868
Neoplasm progression	140.14	21.79	7	345110	44479	90238851
Liver disorder	139.91	21.79	865	344252	120404	90162926
Colitis	139.63	21.79	46	345071	69896	90213434
Haematochezia	139.20	21.79	48	345069	70865	90212465
Pulmonary oedema	138.49	21.79	33	345084	62047	90221283
Skin ulcer	137.59	21.79	15	345102	50060	90233270
Burning sensation	137.15	21.79	36	345081	63416	90219914
Bone pain	136.21	21.79	34	345083	61949	90221381
Hyperglycaemia	135.74	21.79	17	345100	50953	90232377
Hypoxia	135.37	21.79	53	345064	72346	90210984
Premature delivery	132.95	21.79	3	345114	38759	90244571
Therapy interrupted	132.75	21.79	17	345100	50091	90233239
Disorientation	132.69	21.79	9	345108	44105	90239225
Septic shock	132.35	21.79	78	345039	84082	90199248
Hallucination	132.35	21.79	43	345074	65916	90217414
Ascites	131.94	21.79	14	345103	47726	90235604
Multiple sclerosis relapse	130.98	21.79	21	345096	52284	90231046
Swollen tongue	130.88	21.79	12	345105	45944	90237386
Gamma-glutamyltransferase increased	129.93	21.79	3	345114	37949	90245381
Drug ineffective for unapproved indication	129.29	21.79	46	345071	66598	90216732
Injection site swelling	129.24	21.79	34	345083	59805	90223525
Walking aid user	128.81	21.79	361	344756	35145	90248185
Liver function test abnormal	126.01	21.79	21	345096	50824	90232506
Hepatic failure	125.95	21.79	6	345111	39722	90243608
Injection site pruritus	125.36	21.79	26	345091	53808	90229522
Breast cancer	125.12	21.79	26	345091	53735	90229595
Hypothyroidism	125.08	21.79	25	345092	53102	90230228
Drug reaction with eosinophilia and systemic symptoms	124.96	21.79	10	345107	42748	90240582
Encephalopathy	124.89	21.79	15	345102	46429	90236901
Haemorrhage	124.50	21.79	54	345063	69315	90214015
Rash erythematous	124.49	21.79	46	345071	65058	90218272
Rash maculo-papular	124.15	21.79	8	345109	40925	90242405
Rhinorrhoea	122.57	21.79	94	345023	88222	90195108
Migraine	122.52	21.79	1185	343932	189207	90094123
Seronegative arthritis	122.21	21.79	236	344881	17998	90265332
Device expulsion	121.07	21.79	9	345108	40877	90242453
Breast cancer stage II	120.17	21.79	351	344766	34983	90248347
Pneumonitis	119.43	21.79	14	345103	44156	90239174
Femur fracture	118.84	21.79	17	345100	46065	90237265
Weight decreased	118.54	21.79	903	344214	379007	89904323
Dysphonia	118.25	21.79	46	345071	63038	90220292
Illness	117.96	21.79	84	345033	81885	90201445
Osteonecrosis of jaw	117.54	21.79	8	345109	39095	90244235
Speech disorder	117.13	21.79	17	345100	45568	90237762
Drug eruption	116.79	21.79	4	345113	35403	90247927
Transient ischaemic attack	115.96	21.79	14	345103	43162	90240168
Red blood cell count decreased	115.19	21.79	19	345098	46332	90236998
Mouth ulceration	115.02	21.79	10	345107	39964	90243366
Pneumonia	114.56	21.79	1725	343392	636334	89646996
Blood alkaline phosphatase increased	114.51	21.79	22	345095	48057	90235273
Eczema	114.26	21.79	30	345087	52840	90230490
Asthenia	113.83	21.79	1393	343724	532358	89750972
Orthostatic hypotension	113.74	21.79	13	345104	41814	90241516
Hepatotoxicity	113.46	21.79	19	345098	45823	90237507
Skin discolouration	112.77	21.79	17	345100	44298	90239032
Lymphocyte count decreased	112.07	21.79	5	345112	35045	90248285
Intentional product misuse	111.37	21.79	106	345011	89498	90193832
Pulmonary hypertension	111.27	21.79	15	345102	42508	90240822
Memory impairment	110.83	21.79	1194	343923	196050	90087280
Transaminases increased	110.66	21.79	8	345109	37184	90246146
Hypertension	110.28	21.79	2396	342721	455136	89828194
Aphasia	109.92	21.79	16	345101	42796	90240534
Depressed mood	109.49	21.79	28	345089	50194	90233136
Lymphadenopathy	108.90	21.79	21	345096	45754	90237576
Hot flush	108.85	21.79	45	345072	59443	90223887
Injection site bruising	108.72	21.79	32	345085	52275	90231055
Full blood count abnormal	108.53	21.79	8	345109	36589	90246741
Pancreatitis acute	108.19	21.79	3	345114	32112	90251218
International normalised ratio increased	107.84	21.79	24	345093	47292	90236038
Hypomagnesaemia	107.80	21.79	7	345110	35581	90247749
Cardiac disorder	107.38	21.79	41	345076	56831	90226499
Dry eye	107.34	21.79	43	345074	57888	90225442
Drug tolerance decreased	107.19	21.79	317	344800	31813	90251517
Angina pectoris	106.91	21.79	12	345105	39148	90244182
Hypercalcaemia	105.94	21.79	6	345111	34234	90249096
Melaena	104.95	21.79	7	345110	34790	90248540
Diverticulitis	104.86	21.79	22	345095	45165	90238165
Haematoma	104.04	21.79	13	345104	39035	90244295
Pneumonia aspiration	103.50	21.79	16	345101	40924	90242406
Localised infection	103.48	21.79	6	345111	33556	90249774
Musculoskeletal pain	103.43	21.79	1052	344065	170199	90113131
Throat irritation	102.66	21.79	29	345088	48666	90234664
Blood creatine phosphokinase increased	102.16	21.79	7	345110	34016	90249314
Productive cough	101.97	21.79	86	345031	76977	90206353
Hepatic steatosis	101.68	21.79	11	345106	36934	90246396
Product prescribing error	100.88	21.79	3	345114	30142	90253188
Dyspnoea	100.54	21.79	2571	342546	878384	89404946
Serotonin syndrome	100.01	21.79	13	345104	37874	90245456
Altered state of consciousness	99.20	21.79	5	345112	31527	90251803
Chronic kidney disease	98.46	21.79	34	345083	50157	90233173
Cerebral haemorrhage	98.35	21.79	9	345108	34513	90248817
Hypophagia	98.14	21.79	11	345106	35926	90247404
Anaphylactic reaction	98.14	21.79	113	345004	87411	90195919
Stevens-Johnson syndrome	98.03	21.79	3	345114	29373	90253957
Tinnitus	97.95	21.79	22	345095	43080	90240250
Dyskinesia	97.74	21.79	12	345105	36522	90246808
Cholelithiasis	97.24	21.79	39	345078	52467	90230863
Tachycardia	96.63	21.79	294	344823	157379	90125951
Plasma cell myeloma	96.56	21.79	19	345098	40809	90242521
Headache	96.54	21.79	2525	342592	860221	89423109
Hepatocellular injury	96.48	21.79	3	345114	28955	90254375
Anaphylactic shock	96.42	21.79	6	345111	31611	90251719
Unevaluable event	96.37	21.79	44	345073	54804	90228526
Pericardial effusion	96.36	21.79	13	345104	36820	90246510
Skin lesion	95.85	21.79	14	345103	37351	90245979
Foetal exposure during pregnancy	95.55	21.79	23	345094	42952	90240378
Product quality issue	95.38	21.79	572	344545	78753	90204577
Joint dislocation	95.21	21.79	379	344738	44203	90239127
Pain in jaw	95.01	21.79	32	345085	47953	90235377
Dysgeusia	94.18	21.79	41	345076	52519	90230811
Disturbance in attention	94.00	21.79	31	345086	47078	90236252
Jaundice	93.93	21.79	8	345109	32509	90250821
Eye pain	93.68	21.79	26	345091	44142	90239188
Epilepsy	93.31	21.79	584	344533	81622	90201708
Drug level increased	92.05	21.79	3	345114	27759	90255571
Basal cell carcinoma	91.74	21.79	10	345107	33379	90249951
Arrhythmia	91.52	21.79	24	345093	42308	90241022
Diabetes mellitus	91.37	21.79	68	345049	64807	90218523
Staphylococcal infection	91.32	21.79	35	345082	48404	90234926
Vomiting	91.11	21.79	2296	342821	785997	89497333
Blood potassium decreased	90.79	21.79	34	345083	47693	90235637
Back injury	90.61	21.79	385	344732	46237	90237093
Hepatic cirrhosis	90.55	21.79	478	344639	62775	90220555
Porphyria acute	90.55	21.79	207	344910	17768	90265562
Surgery	90.52	21.79	29	345088	44858	90238472
Pallor	89.52	21.79	12	345105	34153	90249177
Metastases to liver	89.27	21.79	5	345112	28802	90254528
Lip swelling	89.18	21.79	19	345098	38591	90244739
Shock	89.17	21.79	5	345112	28773	90254557
Presyncope	88.74	21.79	9	345108	31796	90251534
Blood calcium decreased	88.36	21.79	7	345110	30175	90253155
Pregnancy	88.22	21.79	468	344649	61579	90221751
Mental status changes	88.11	21.79	30	345087	44649	90238681
Haematemesis	88.00	21.79	12	345105	33714	90249616
Restlessness	87.97	21.79	15	345102	35705	90247625
Therapy cessation	87.96	21.79	16	345101	36345	90246985
Gastritis	87.77	21.79	25	345092	41728	90241602
Cytomegalovirus infection	87.76	21.79	3	345114	26599	90256731
Generalised tonic-clonic seizure	87.42	21.79	14	345103	34889	90248441
Acute myocardial infarction	87.38	21.79	14	345103	34876	90248454
Nephrolithiasis	86.83	21.79	39	345078	49046	90234284
Delirium	86.58	21.79	687	344430	103672	90179658
Palmar-plantar erythrodysaesthesia syndrome	86.42	21.79	5	345112	28018	90255312
Acute respiratory distress syndrome	85.84	21.79	6	345111	28680	90254650
Subcutaneous drug absorption impaired	85.55	21.79	171	344946	13374	90269956
Blood pressure diastolic decreased	85.21	21.79	4	345113	26822	90256508
Haematocrit decreased	84.40	21.79	27	345090	41805	90241525
Psychotic disorder	84.18	21.79	10	345107	31220	90252110
Ejection fraction decreased	83.11	21.79	4	345113	26249	90257081
Osteonecrosis	83.07	21.79	4	345113	26237	90257093
Nasal congestion	82.85	21.79	118	344999	83296	90200034
Foot deformity	82.81	21.79	447	344670	59204	90224126
Gastroenteritis	82.26	21.79	8	345109	29221	90254109
Premature baby	82.13	21.79	3	345114	25074	90258256
Disability	81.94	21.79	340	344777	40405	90242925
Dyspepsia	81.89	21.79	1132	343985	197028	90086302
Cerebral infarction	81.25	21.79	5	345112	26591	90256739
Accidental exposure to product	80.89	21.79	30	345087	42336	90240994
Renal disorder	80.83	21.79	22	345095	37837	90245493
Respiratory distress	80.62	21.79	24	345093	38922	90244408
Acute respiratory failure	79.28	21.79	32	345085	42886	90240444
Hemiparesis	79.17	21.79	13	345104	31806	90251524
Maternal exposure timing unspecified	79.01	21.79	226	344891	22257	90261073
Obstructive airways disorder	78.62	21.79	5	345112	25864	90257466
Fungal infection	78.49	21.79	32	345085	42629	90240701
Device dislocation	78.02	21.79	13	345104	31469	90251861
Neoplasm malignant	77.58	21.79	17	345100	33863	90249467
Product label confusion	76.75	21.79	226	344891	22624	90260706
Blood urea increased	76.63	21.79	12	345105	30401	90252929
Clostridium difficile colitis	75.98	21.79	7	345110	26699	90256631
Adverse drug reaction	75.84	21.79	728	344389	115973	90167357
Abdominal pain lower	75.82	21.79	12	345105	30165	90253165
Device related infection	75.44	21.79	6	345111	25780	90257550
Ocular hyperaemia	75.31	21.79	18	345099	33780	90249550
Haematuria	75.16	21.79	20	345097	34917	90248413
Flatulence	74.55	21.79	32	345085	41335	90241995
Urinary incontinence	74.47	21.79	25	345092	37541	90245789
Lymphopenia	74.04	21.79	3	345114	22878	90260452
Device issue	73.64	21.79	12	345105	29525	90253805
Cardiogenic shock	73.56	21.79	5	345112	24463	90258867
Dysuria	73.40	21.79	29	345088	39372	90243958
Rash pruritic	73.36	21.79	125	344992	82089	90201241
Viral infection	73.11	21.79	33	345084	41381	90241949
Vaginal haemorrhage	73.02	21.79	15	345102	31256	90252074
Blindness	72.89	21.79	8	345109	26560	90256770
Oral herpes	72.48	21.79	19	345098	33505	90249825
Ulcer haemorrhage	72.46	21.79	243	344874	26078	90257252
Leukocytosis	72.09	21.79	15	345102	30975	90252355
Irritability	71.98	21.79	23	345094	35639	90247691
Bacteraemia	71.90	21.79	3	345114	22297	90261033
Food allergy	71.63	21.79	7	345110	25471	90257859
Eating disorder	70.90	21.79	11	345106	28062	90255268
Candida infection	70.47	21.79	21	345096	34036	90249294
Eosinophilia	70.23	21.79	12	345105	28521	90254809
Haemoptysis	69.95	21.79	20	345097	33300	90250030
Hip fracture	69.17	21.79	20	345097	33057	90250273
Metastases to bone	69.16	21.79	8	345109	25497	90257833
Disseminated intravascular coagulation	69.10	21.79	3	345114	21535	90261795
Coronary artery disease	69.09	21.79	21	345096	33602	90249728
Pollakiuria	68.94	21.79	20	345097	32985	90250345
Sopor	68.69	21.79	7	345110	24637	90258693
Body temperature decreased	68.41	21.79	6	345111	23810	90259520
Hypervolaemia	68.15	21.79	20	345097	32737	90250593
Finger deformity	67.32	21.79	276	344841	32621	90250709
Skin disorder	66.78	21.79	28	345089	36678	90246652
Mental disorder	66.74	21.79	20	345097	32298	90251032
Pulmonary arterial hypertension	66.74	21.79	10	345107	26177	90257153
Acute hepatic failure	66.70	21.79	5	345112	22556	90260774
Diplopia	66.58	21.79	14	345103	28700	90254630
Gastric ulcer	66.56	21.79	12	345105	27436	90255894
Proteinuria	66.54	21.79	6	345111	23285	90260045
Coagulopathy	66.54	21.79	6	345111	23283	90260047
Liver function test increased	66.26	21.79	551	344566	84304	90199026
Aggression	66.12	21.79	11	345106	26657	90256673
Sinus tachycardia	65.91	21.79	14	345103	28499	90254831
Posterior reversible encephalopathy syndrome	65.91	21.79	5	345112	22334	90260996
Hallucination, visual	65.84	21.79	6	345111	23086	90260244
Therapy non-responder	65.73	21.79	803	344314	135901	90147429
Upper gastrointestinal haemorrhage	65.42	21.79	6	345111	22970	90260360
Skin haemorrhage	65.37	21.79	4	345113	21376	90261954
Rib fracture	65.32	21.79	11	345106	26424	90256906
Urinary retention	65.20	21.79	31	345086	37713	90245617
Panic attack	65.09	21.79	11	345106	26354	90256976
Fracture	64.97	21.79	5	345112	22071	90261259
Abnormal behaviour	64.19	21.79	6	345111	22622	90260708
Limb injury	64.17	21.79	20	345097	31488	90251842
Rheumatoid nodule	64.07	21.79	3	345114	20163	90263167
Acne	63.88	21.79	15	345102	28492	90254838
No adverse event	63.80	21.79	100	345017	67882	90215448
Nightmare	63.71	21.79	5	345112	21720	90261610
Osteomyelitis	63.71	21.79	14	345103	27832	90255498
Eye irritation	63.31	21.79	25	345092	33953	90249377
Unresponsive to stimuli	63.30	21.79	33	345084	38088	90245242
Injection site haemorrhage	63.26	21.79	15	345102	28303	90255027
Nervous system disorder	63.24	21.79	5	345112	21588	90261742
Diabetic ketoacidosis	62.94	21.79	9	345108	24398	90258932
Dysstasia	62.86	21.79	10	345107	25042	90258288
Joint injury	62.58	21.79	23	345094	32641	90250689
Peritonitis	62.39	21.79	3	345114	19702	90263628
Amnesia	62.38	21.79	660	344457	107845	90175485
Clostridium difficile infection	62.25	21.79	30	345087	36215	90247115
Full blood count decreased	62.00	21.79	18	345099	29671	90253659
Exposure during pregnancy	61.69	21.79	1262	343855	237148	90046182
Ventricular tachycardia	61.68	21.79	10	345107	24698	90258632
Face oedema	61.55	21.79	8	345109	23310	90260020
Head injury	61.39	21.79	21	345096	31167	90252163
Throat tightness	61.34	21.79	18	345099	29466	90253864
Dementia	61.06	21.79	9	345108	23852	90259478
Myelodysplastic syndrome	60.77	21.79	5	345112	20898	90262432
Electrolyte imbalance	60.67	21.79	9	345108	23736	90259594
Neuralgia	60.65	21.79	22	345095	31478	90251852
Rash macular	60.28	21.79	20	345097	30260	90253070
General symptom	60.09	21.79	156	344961	14512	90268818
Multiple sclerosis	59.77	21.79	16	345101	27824	90255506
Respiratory arrest	59.66	21.79	26	345091	33285	90250045
Pyelonephritis	59.55	21.79	6	345111	21310	90262020
Visual acuity reduced	59.52	21.79	9	345108	23401	90259929
Vasculitis	59.39	21.79	8	345109	22685	90260645
Status epilepticus	59.35	21.79	3	345114	18871	90264459
Urosepsis	59.26	21.79	6	345111	21226	90262104
Eye swelling	59.23	21.79	19	345098	29367	90253963
Withdrawal syndrome	58.80	21.79	8	345109	22516	90260814
Diabetes mellitus inadequate control	58.66	21.79	3	345114	18681	90264649
Feeling cold	58.56	21.79	16	345101	27449	90255881
Cardiomyopathy	58.29	21.79	5	345112	20201	90263129
Caesarean section	58.27	21.79	3	345114	18574	90264756
Neutrophil count increased	58.18	21.79	4	345113	19386	90263944
Lung neoplasm malignant	58.03	21.79	11	345106	24262	90259068
Polyneuropathy	58.01	21.79	4	345113	19337	90263993
Therapeutic response shortened	57.70	21.79	9	345108	22870	90260460
Injection site rash	57.69	21.79	11	345106	24162	90259168
Condition aggravated	57.62	21.79	2796	342321	592749	89690581
Injection site mass	57.31	21.79	8	345109	22082	90261248
Gastric disorder	56.78	21.79	28	345089	33356	90249974
Respiratory tract infection	56.30	21.79	86	345031	58992	90224338
Disease recurrence	56.28	21.79	37	345080	37616	90245714
Product substitution issue	56.19	21.79	3	345114	18005	90265325
Drug dependence	55.60	21.79	21	345096	29306	90254024
Pulmonary mass	55.56	21.79	20	345097	28752	90254578
Kidney infection	55.44	21.79	15	345102	25901	90257429
Ischaemic stroke	55.27	21.79	9	345108	22157	90261173
Bacterial infection	55.25	21.79	11	345106	23433	90259897
Malnutrition	55.19	21.79	4	345113	18554	90264776
Eye pruritus	54.67	21.79	21	345096	29006	90254324
Metastases to central nervous system	54.50	21.79	3	345114	17539	90265791
Injection site warmth	54.40	21.79	3	345114	17512	90265818
Haemorrhoids	54.29	21.79	17	345100	26685	90256645
Skin laceration	53.97	21.79	16	345101	26019	90257311
Heart rate irregular	53.93	21.79	13	345104	24255	90259075
Musculoskeletal disorder	53.92	21.79	9	345108	21760	90261570
Ulcer	53.81	21.79	29	345088	32853	90250477
Procedural pain	53.75	21.79	30	345087	33330	90250000
Bronchiectasis	53.64	21.79	10	345107	22320	90261010
Eye injury	53.41	21.79	125	344992	10895	90272435
Blood glucose decreased	53.15	21.79	12	345105	23417	90259913
Subarachnoid haemorrhage	52.84	21.79	4	345113	17900	90265430
Rash vesicular	52.77	21.79	171	344946	18026	90265304
Hypoacusis	52.70	21.79	20	345097	27830	90255500
Chronic obstructive pulmonary disease	52.46	21.79	128	344989	73701	90209629
Intervertebral disc protrusion	52.36	21.79	19	345098	27177	90256153
Abdominal pain upper	52.27	21.79	1647	343470	331027	89952303
Motor dysfunction	52.22	21.79	6	345111	19224	90264106
Drug withdrawal syndrome	52.11	21.79	22	345095	28701	90254629
Body temperature increased	52.01	21.79	56	345061	44654	90238676
Lacrimation increased	51.94	21.79	19	345098	27043	90256287
Pustular psoriasis	51.69	21.79	172	344945	18384	90264946
Mental impairment	51.51	21.79	3	345114	16717	90266613
Dizziness	51.29	21.79	1783	343334	587501	89695829
Cytopenia	51.21	21.79	4	345113	17445	90265885
Crying	50.95	21.79	17	345100	25628	90257702
Poor venous access	50.83	21.79	7	345110	19520	90263810
Complication associated with device	50.56	21.79	7	345110	19442	90263888
C-reactive protein increased	50.54	21.79	971	344146	180418	90102912
Injection site urticaria	50.50	21.79	5	345112	18006	90265324
Blood potassium increased	50.47	21.79	9	345108	20740	90262590
Coordination abnormal	50.37	21.79	10	345107	21346	90261984
Bronchospasm	50.33	21.79	9	345108	20700	90262630
Spondylitis	50.29	21.79	143	344974	14035	90269295
Faeces discoloured	50.25	21.79	10	345107	21310	90262020
Paraesthesia oral	50.25	21.79	29	345088	31630	90251700
Tachypnoea	50.22	21.79	10	345107	21299	90262031
Oral candidiasis	50.13	21.79	37	345080	35418	90247912
Malaise	50.09	21.79	1777	343340	584209	89699121
Hiatus hernia	50.05	21.79	17	345100	25344	90257986
Small intestinal obstruction	49.97	21.79	10	345107	21224	90262106
Product administration error	49.96	21.79	19	345098	26404	90256926
Muscle twitching	49.94	21.79	15	345102	24187	90259143
Intestinal obstruction	49.65	21.79	41	345076	37090	90246240
Skin necrosis	49.40	21.79	4	345113	16937	90266393
Generalised oedema	49.19	21.79	7	345110	19046	90264284
Dermatitis	49.18	21.79	12	345105	22208	90261122
Blood test abnormal	49.03	21.79	10	345107	20942	90262388
Foot fracture	48.88	21.79	20	345097	26586	90256744
Metastases to lung	48.87	21.79	3	345114	15988	90267342
Device difficult to use	48.79	21.79	5	345112	17520	90265810
Feeding disorder	48.74	21.79	5	345112	17507	90265823
Bone disorder	48.31	21.79	14	345103	23106	90260224
Brain oedema	48.29	21.79	5	345112	17380	90265950
Cyanosis	48.29	21.79	8	345109	19447	90263883
Iron deficiency anaemia	48.22	21.79	15	345102	23647	90259683
Sensory loss	48.20	21.79	6	345111	18069	90265261
Bone density decreased	48.15	21.79	5	345112	17340	90265990
Eye disorder	48.08	21.79	22	345095	27368	90255962
Spinal pain	48.06	21.79	3	345114	15764	90267566
Poor quality sleep	47.96	21.79	17	345100	24676	90258654
Oesophagitis	47.81	21.79	5	345112	17244	90266086
Progressive multifocal leukoencephalopathy	47.65	21.79	3	345114	15652	90267678
Heavy menstrual bleeding	47.62	21.79	10	345107	20520	90262810
Conjunctivitis	47.58	21.79	21	345096	26685	90256645
Coeliac disease	47.58	21.79	312	344805	44298	90239032
Flank pain	47.50	21.79	8	345109	19214	90264116
Photosensitivity reaction	47.27	21.79	6	345111	17801	90265529
Tooth disorder	47.22	21.79	30	345087	31060	90252270
Blood sodium decreased	47.20	21.79	23	345094	27590	90255740
Ankle fracture	47.09	21.79	10	345107	20360	90262970
Device malfunction	47.08	21.79	11	345106	20966	90262364
Hemiplegia	46.61	21.79	4	345113	16156	90267174
Glaucoma	46.35	21.79	11	345106	20744	90262586
Cardiac murmur	46.24	21.79	7	345110	18187	90265143
Spinal compression fracture	45.93	21.79	3	345114	15175	90268155
Toxic epidermal necrolysis	45.92	21.79	34	345083	32494	90250836
Treatment noncompliance	45.82	21.79	79	345038	51648	90231682
Uveitis	45.70	21.79	4	345113	15899	90267431
Rales	45.42	21.79	4	345113	15823	90267507
Ileus	45.34	21.79	5	345112	16541	90266789
Mydriasis	45.33	21.79	3	345114	15009	90268321
Petechiae	45.12	21.79	4	345113	15737	90267593
Hypokinesia	44.96	21.79	4	345113	15693	90267637
Infusion site reaction	44.86	21.79	167	344950	18872	90264458
Blood pressure abnormal	44.69	21.79	10	345107	19635	90263695
Mitral valve incompetence	44.63	21.79	15	345102	22509	90260821
Hypoaesthesia oral	44.62	21.79	4	345113	15596	90267734
Skin burning sensation	44.58	21.79	10	345107	19601	90263729
Pharyngitis	44.57	21.79	14	345103	21933	90261397
Hypothermia	44.53	21.79	4	345113	15571	90267759
Nail operation	44.37	21.79	45	345072	1861	90281469
Sinus bradycardia	44.30	21.79	6	345111	16946	90266384
Abscess	44.24	21.79	9	345108	18882	90264448
Transfusion	43.83	21.79	7	345110	17481	90265849
Respiratory tract congestion	43.66	21.79	25	345092	27385	90255945
Accidental overdose	43.33	21.79	27	345090	28246	90255084
Subdural haematoma	43.25	21.79	6	345111	16639	90266691
Right ventricular failure	43.24	21.79	10	345107	19195	90264135
Spinal fracture	43.03	21.79	15	345102	22001	90261329
Breast cancer metastatic	42.96	21.79	4	345113	15128	90268202
Deafness	42.88	21.79	16	345101	22498	90260832
Product storage error	42.77	21.79	12	345105	20229	90263101
Emotional distress	42.55	21.79	46	345071	36616	90246714
Sleep apnoea syndrome	42.52	21.79	35	345082	31712	90251618
Gingival bleeding	42.15	21.79	4	345113	14899	90268431
Parkinsonism	41.92	21.79	3	345114	14062	90269268
COVID-19 pneumonia	41.86	21.79	9	345108	18168	90265162
Anuria	41.85	21.79	4	345113	14814	90268516
Purpura	41.70	21.79	4	345113	14774	90268556
Impaired work ability	41.69	21.79	11	345106	19315	90264015
Blood albumin decreased	41.50	21.79	7	345110	16796	90266534
Spinal stenosis	41.43	21.79	8	345109	17416	90265914
Sensory disturbance	41.38	21.79	5	345112	15408	90267922
Pelvic pain	41.19	21.79	5	345112	15352	90267978
Retching	41.15	21.79	11	345106	19148	90264182
Ovarian cyst	41.08	21.79	8	345109	17310	90266020
Escherichia urinary tract infection	41.02	21.79	3	345114	13812	90269518
Tenosynovitis	40.96	21.79	4	345113	14563	90268767
Red blood cell sedimentation rate increased	40.92	21.79	488	344629	82107	90201223
Joint stiffness	40.85	21.79	466	344651	77576	90205754
Ear infection	40.84	21.79	426	344691	69349	90213981
Skin infection	40.83	21.79	9	345108	17855	90265475
Swollen joint count	40.69	21.79	97	345020	8556	90274774
Musculoskeletal chest pain	40.27	21.79	20	345097	23730	90259600
Oral pain	40.21	21.79	39	345078	32644	90250686
Bronchitis	40.19	21.79	380	344737	152547	90130783
Hypocalcaemia	40.06	21.79	62	345055	42306	90241024
Muscle rigidity	40.05	21.79	4	345113	14305	90269025
Mass	39.58	21.79	6	345111	15571	90267759
Osteopenia	39.56	21.79	19	345098	22983	90260347
Glycosylated haemoglobin increased	39.52	21.79	6	345111	15556	90267774
Pneumothorax	39.33	21.79	12	345105	19155	90264175
Skin fissures	39.28	21.79	15	345102	20794	90262536
Hepatomegaly	39.27	21.79	3	345114	13323	90270007
Ventricular fibrillation	39.11	21.79	4	345113	14040	90269290
Pain of skin	39.06	21.79	7	345110	16075	90267255
Dermatitis allergic	39.06	21.79	9	345108	17318	90266012
Ventricular extrasystoles	38.99	21.79	3	345114	13247	90270083
Blood urine present	38.90	21.79	9	345108	17269	90266061
Thyroid disorder	38.60	21.79	10	345107	17775	90265555
Intestinal perforation	38.54	21.79	4	345113	13877	90269453
Mood altered	38.46	21.79	9	345108	17135	90266195
Renal tubular necrosis	38.40	21.79	5	345112	14550	90268780
Carpal tunnel syndrome	37.86	21.79	22	345095	23906	90259424
Atelectasis	37.84	21.79	23	345094	24386	90258944
Tendonitis	37.77	21.79	17	345100	21355	90261975
Extrapyramidal disorder	37.70	21.79	8	345109	16295	90267035
Chromaturia	37.63	21.79	13	345104	19174	90264156
Wrist fracture	37.52	21.79	7	345110	15617	90267713
Drug tolerance	37.20	21.79	151	344966	17765	90265565
Hypophosphataemia	37.11	21.79	6	345111	14848	90268482
Impaired quality of life	37.02	21.79	21	345096	23123	90260207
Intervertebral disc degeneration	36.95	21.79	10	345107	17264	90266066
Fear	36.75	21.79	9	345108	16613	90266717
Product dose omission in error	36.72	21.79	16	345101	20487	90262843
Device breakage	36.63	21.79	5	345112	14039	90269291
Musculoskeletal discomfort	36.62	21.79	17	345100	20974	90262356
Hallucination, auditory	36.61	21.79	8	345109	15967	90267363
Troponin increased	36.43	21.79	4	345113	13277	90270053
Lung infiltration	36.37	21.79	7	345110	15275	90268055
Arterial occlusive disease	36.12	21.79	3	345114	12443	90270887
Nervousness	36.02	21.79	46	345071	34010	90249320
Hydronephrosis	35.96	21.79	3	345114	12399	90270931
Ataxia	35.77	21.79	12	345105	18030	90265300
Mood swings	35.76	21.79	17	345100	20685	90262645
Eosinophil count increased	35.73	21.79	4	345113	13077	90270253
Blood iron decreased	35.51	21.79	12	345105	17947	90265383
Post procedural complication	35.49	21.79	14	345103	19028	90264302
Acute generalised exanthematous pustulosis	35.46	21.79	5	345112	13698	90269632
Hypersomnia	35.22	21.79	19	345098	21512	90261818
Tricuspid valve incompetence	35.20	21.79	10	345107	16721	90266609
Dermatitis atopic	35.17	21.79	23	345094	23449	90259881
Facial paralysis	35.15	21.79	8	345109	15526	90267804
Joint destruction	35.10	21.79	121	344996	13166	90270164
Lymphoma	35.07	21.79	5	345112	13586	90269744
Ageusia	34.97	21.79	9	345108	16067	90267263
Cyst	34.65	21.79	10	345107	16551	90266779
Postoperative wound infection	34.51	21.79	5	345112	13421	90269909
Toothache	34.38	21.79	21	345096	22209	90261121
Cholecystitis	34.37	21.79	11	345106	17029	90266301
Needle issue	33.99	21.79	6	345111	13928	90269402
Supraventricular tachycardia	33.93	21.79	10	345107	16326	90267004
Head discomfort	33.92	21.79	10	345107	16323	90267007
Anxiety	33.84	21.79	909	344208	308863	89974467
Gout	33.80	21.79	11	345106	16848	90266482
Hyperlipidaemia	33.60	21.79	23	345094	22893	90260437
Ankylosing spondylitis	33.50	21.79	5	345112	13128	90270202
Hypovolaemia	33.46	21.79	4	345113	12427	90270903
Sinus congestion	33.42	21.79	33	345084	27391	90255939
Sputum discoloured	33.34	21.79	18	345099	20373	90262957
Central nervous system lesion	33.27	21.79	3	345114	11643	90271687
Hepatic enzyme	33.19	21.79	67	345050	5277	90278053
Medication error	33.10	21.79	479	344638	84173	90199157
Pseudomonas infection	32.96	21.79	8	345109	14857	90268473
Skin irritation	32.87	21.79	6	345111	13597	90269733
Hernia	32.87	21.79	7	345110	14224	90269106
Breath sounds abnormal	32.73	21.79	9	345108	15377	90267953
Vitamin D deficiency	32.57	21.79	13	345104	17543	90265787
Upper limb fracture	32.53	21.79	21	345096	21557	90261773
Cardiovascular disorder	32.50	21.79	6	345111	13486	90269844
Psychomotor hyperactivity	32.41	21.79	5	345112	12808	90270522
Anal incontinence	31.82	21.79	11	345106	16219	90267111
Peripheral coldness	31.75	21.79	7	345110	13885	90269445
Urine output decreased	31.69	21.79	5	345112	12598	90270732
Akathisia	31.54	21.79	3	345114	11156	90272174
Synovial cyst	31.10	21.79	4	345113	11748	90271582
Restless legs syndrome	31.06	21.79	24	345093	22446	90260884
Eye infection	30.97	21.79	8	345109	14246	90269084
Colon cancer	30.78	21.79	3	345114	10941	90272389
Sudden death	30.66	21.79	3	345114	10906	90272424
Hepatitis acute	30.58	21.79	3	345114	10884	90272446
Eructation	30.56	21.79	3	345114	10879	90272451
Nasal polyps	30.56	21.79	3	345114	10877	90272453
Skin cancer	30.52	21.79	7	345110	13512	90269818
Tongue disorder	30.49	21.79	3	345114	10857	90272473
Grip strength	30.42	21.79	89	345028	8876	90274454
Cold sweat	30.40	21.79	8	345109	14073	90269257
Red cell distribution width increased	30.34	21.79	5	345112	12202	90271128
Rhinitis allergic	30.22	21.79	13	345104	16772	90266558
Blood magnesium decreased	30.15	21.79	11	345106	15682	90267648
Hypocholesterolaemia	30.01	21.79	72	345045	6377	90276953
Tooth infection	29.90	21.79	20	345097	20150	90263180
Immunosuppression	29.90	21.79	5	345112	12072	90271258
Sarcoidosis	29.83	21.79	3	345114	10670	90272660
Choking	29.75	21.79	5	345112	12028	90271302
Myositis	29.64	21.79	175	344942	23953	90259377
Dialysis	29.63	21.79	4	345113	11325	90272005
Malignant melanoma	29.43	21.79	6	345111	12570	90270760
Pharyngeal oedema	29.40	21.79	8	345109	13763	90269567
Cardiac failure acute	29.40	21.79	5	345112	11924	90271406
Micturition urgency	29.30	21.79	4	345113	11229	90272101
Quality of life decreased	29.26	21.79	5	345112	11884	90271446
Anger	29.24	21.79	8	345109	13712	90269618
Abdominal distension	29.22	21.79	337	344780	130264	90153066
Cardiomegaly	29.10	21.79	18	345099	18907	90264423
Tooth abscess	29.09	21.79	13	345104	16400	90266930
Cushingoid	28.85	21.79	3	345114	10392	90272938
Increased appetite	28.84	21.79	5	345112	11760	90271570
Concussion	28.81	21.79	4	345113	11087	90272243
Arthralgia	28.74	21.79	3385	341732	775137	89508193
Pelvic fracture	28.68	21.79	11	345106	15208	90268122
Product dispensing error	28.42	21.79	6	345111	12267	90271063
Nocturia	28.36	21.79	3	345114	10252	90273078
Drug dose omission by device	28.27	21.79	3	345114	10228	90273102
Appendicitis	28.27	21.79	3	345114	10228	90273102
Tardive dyskinesia	28.26	21.79	4	345113	10926	90272404
Drug ineffective	28.16	21.79	4740	340377	1379558	88903772
Bedridden	28.01	21.79	6	345111	12142	90271188
Acidosis	27.95	21.79	7	345110	12729	90270601
Sinus disorder	27.52	21.79	56	345061	34391	90248939
Diarrhoea haemorrhagic	27.34	21.79	4	345113	10659	90272671
Thirst	27.21	21.79	14	345103	16281	90267049
Gestational diabetes	27.06	21.79	4	345113	10578	90272752
Scratch	26.99	21.79	3	345114	9863	90273467
Incorrect route of product administration	26.81	21.79	303	344814	50323	90233007
Product complaint	26.73	21.79	9	345108	13491	90269839
Oral discomfort	26.72	21.79	4	345113	10479	90272851
Product use in unapproved indication	26.68	21.79	1550	343567	334686	89948644
Aphonia	26.60	21.79	7	345110	12312	90271018
Gastrointestinal infection	26.23	21.79	5	345112	10985	90272345
Pharyngitis streptococcal	26.10	21.79	8	345109	12734	90270596
Electrocardiogram abnormal	26.09	21.79	4	345113	10294	90273036
Scar	26.05	21.79	13	345104	15382	90267948
Concomitant disease aggravated	25.93	21.79	6	345111	11512	90271818
Multiple fractures	25.93	21.79	3	345114	9559	90273771
Therapeutic response unexpected	25.90	21.79	27	345090	21853	90261477
Spinal fusion surgery	25.88	21.79	104	345013	12179	90271151
Femoral neck fracture	25.86	21.79	4	345113	10229	90273101
Underdose	25.82	21.79	317	344800	53700	90229630
Paralysis	25.80	21.79	6	345111	11472	90271858
Arteriosclerosis	25.77	21.79	5	345112	10848	90272482
Embolism	25.64	21.79	3	345114	9478	90273852
Cardiotoxicity	25.50	21.79	6	345111	11383	90271947
Congenital anomaly	25.49	21.79	67	345050	6280	90277050
Dyslipidaemia	25.43	21.79	4	345113	10103	90273227
Hypernatraemia	25.31	21.79	3	345114	9384	90273946
Enterococcal infection	25.04	21.79	4	345113	9987	90273343
Device leakage	25.04	21.79	4	345113	9987	90273343
Skin abrasion	25.00	21.79	6	345111	11229	90272101
Blood pressure systolic decreased	24.91	21.79	3	345114	9267	90274063
Muscle tightness	24.85	21.79	10	345107	13429	90269901
Adverse reaction	24.85	21.79	196	344921	29516	90253814
Incontinence	24.84	21.79	10	345107	13425	90269905
Nephropathy	24.78	21.79	3	345114	9232	90274098
Ecchymosis	24.78	21.79	8	345109	12315	90271015
Tenderness	24.75	21.79	40	345077	26828	90256502
Intentional dose omission	24.57	21.79	19	345098	17764	90265566
Injection site induration	24.48	21.79	5	345112	10463	90272867
Post procedural infection	24.47	21.79	6	345111	11068	90272262
Pleuritic pain	24.46	21.79	5	345112	10456	90272874
Sneezing	24.34	21.79	48	345069	29821	90253509
Middle insomnia	24.31	21.79	17	345100	16734	90266596
Chronic sinusitis	24.30	21.79	33	345084	23769	90259561
Lymphoedema	24.21	21.79	11	345106	13742	90269588
Skin reaction	24.18	21.79	21	345096	18532	90264798
Pulmonary congestion	24.13	21.79	23	345094	19410	90263920
Eyelid oedema	24.07	21.79	7	345110	11527	90271803
Pulmonary toxicity	24.06	21.79	7	345110	11524	90271806
Injection site extravasation	24.03	21.79	3	345114	9016	90274314
Gallbladder disorder	23.94	21.79	24	345093	19779	90263551
Tooth fracture	23.92	21.79	9	345108	12591	90270739
Uterine leiomyoma	23.79	21.79	6	345111	10858	90272472
Mania	23.79	21.79	12	345105	14112	90269218
Fatigue	23.73	21.79	4856	340261	1149167	89134163
Acute coronary syndrome	23.62	21.79	6	345111	10807	90272523
Bladder disorder	23.49	21.79	6	345111	10766	90272564
Spinal osteoarthritis	23.38	21.79	23	345094	19125	90264205
Renal cyst	23.36	21.79	10	345107	12940	90270390
Atrioventricular block	23.32	21.79	3	345114	8812	90274518
Rotator cuff syndrome	23.31	21.79	16	345101	15903	90267427
Limb discomfort	23.28	21.79	71	345046	37989	90245341
Colitis ischaemic	23.14	21.79	9	345108	12337	90270993
Feeling jittery	23.11	21.79	15	345102	15356	90267974
Gastrointestinal pain	23.02	21.79	7	345110	11199	90272131
Hereditary angioedema	22.91	21.79	4	345113	9361	90273969
Abdominal tenderness	22.77	21.79	4	345113	9320	90274010
Pharyngeal swelling	22.75	21.79	5	345112	9939	90273391
Initial insomnia	22.73	21.79	4	345113	9306	90274024
Blood triglycerides increased	22.72	21.79	12	345105	13749	90269581
Nerve injury	22.70	21.79	7	345110	11099	90272231
Poisoning	22.68	21.79	15	345102	15202	90268128
Device occlusion	22.63	21.79	4	345113	9278	90274052
Joint effusion	22.58	21.79	25	345092	19685	90263645
Ligament sprain	22.29	21.79	14	345103	14585	90268745
Fear of injection	22.29	21.79	3	345114	8512	90274818
Mouth haemorrhage	22.24	21.79	3	345114	8498	90274832
Pain in extremity	21.82	21.79	1450	343667	449079	89834251

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sinusitis	65.54	13.48	79	13839	47213	42560204
Penile abscess	63.90	13.48	14	13904	151	42607266
Sudden infant death syndrome	49.82	13.48	13	13905	307	42607110
Dyspnoea	46.40	13.48	274	13644	442347	42165070
Multiple allergies	45.83	13.48	23	13895	3705	42603712
Chronic obstructive pulmonary disease	45.21	13.48	77	13841	63037	42544380
Kidney duplex	42.06	13.48	12	13906	399	42607018
Cough	37.05	13.48	135	13783	177968	42429449
Productive cough	37.04	13.48	63	13855	51504	42555913
Cardiac septal defect	32.06	13.48	12	13906	948	42606469
Off label use	30.47	13.48	107	13811	638228	41969189
Bronchitis	30.44	13.48	55	13863	47146	42560271
Asthma-chronic obstructive pulmonary disease overlap syndrome	29.64	13.48	13	13905	1546	42605871
Pneumonia	29.63	13.48	237	13681	421912	42185505
Acute kidney injury	29.11	13.48	47	13871	367290	42240127
Nasal congestion	28.05	13.48	41	13877	29460	42577957
Symmetrical drug-related intertriginous and flexural exanthema	25.92	13.48	10	13908	858	42606559
Mycobacterial infection	23.01	13.48	13	13905	2655	42604762
Priapism	22.84	13.48	18	13900	6389	42601028
SARS-CoV-2 test negative	21.96	13.48	11	13907	1764	42605653
Fatigue	21.60	13.48	227	13691	435414	42172003
Nasopharyngitis	21.23	13.48	68	13850	83928	42523489
Upper respiratory tract infection	19.76	13.48	43	13875	42130	42565287
Anal inflammation	19.60	13.48	11	13907	2218	42605199
Hypoxic-ischaemic encephalopathy	19.38	13.48	15	13903	5187	42602230
Substance abuser	19.22	13.48	6	13912	273	42607144
Product dose omission issue	18.32	13.48	99	13819	154266	42453151
General physical health deterioration	17.79	13.48	14	13904	151232	42456185
Sinus congestion	17.47	13.48	16	13902	6964	42600453
Seasonal allergy	15.52	13.48	16	13902	8039	42599378
Bradycardia	14.34	13.48	5	13913	85479	42521938
Rhabdomyolysis	14.09	13.48	4	13914	78015	42529402
Congenital central nervous system anomaly	13.79	13.48	6	13912	699	42606718
Thrombocytopenia	13.53	13.48	26	13892	190253	42417164

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	2997.42	20.07	3154	271727	211416	110103002
Systemic lupus erythematosus	2863.51	20.07	3339	271542	250999	110063419
Pericarditis	2788.37	20.07	3066	271815	216048	110098370
Glossodynia	2734.65	20.07	3054	271827	218950	110095468
Hand deformity	2705.36	20.07	3014	271867	215492	110098926
Wound	2549.03	20.07	3024	271857	231413	110083005
Anti-cyclic citrullinated peptide antibody positive	2379.67	20.07	2584	272297	179400	110135018
Synovitis	2302.77	20.07	3109	271772	270983	110043435
Duodenal ulcer perforation	2263.89	20.07	2489	272392	175211	110139207
Helicobacter infection	2204.38	20.07	2482	272399	179395	110135023
Folliculitis	1788.43	20.07	2143	272738	165510	110148908
Swelling	1780.99	20.07	3154	271727	347887	109966531
Arthropathy	1772.34	20.07	2819	272062	284703	110029715
Discomfort	1694.19	20.07	2364	272517	212343	110102075
Irritable bowel syndrome	1682.95	20.07	2057	272824	162158	110152260
Alopecia	1622.93	20.07	3097	271784	361656	109952762
Abdominal discomfort	1600.80	20.07	3219	271662	390639	109923779
Muscle injury	1574.40	20.07	1844	273037	138963	110175455
Hepatic enzyme increased	1573.15	20.07	2841	272040	318051	109996367
Rheumatic fever	1487.81	20.07	1675	273206	120904	110193514
Blister	1431.65	20.07	2252	272629	225124	110089294
Rheumatoid factor positive	1425.29	20.07	1696	273185	129944	110184474
Impaired healing	1406.24	20.07	2067	272814	194650	110119768
Infusion related reaction	1369.17	20.07	2962	271919	378200	109936218
Sleep disorder due to general medical condition, insomnia type	1297.97	20.07	1453	273428	104190	110210228
Type 2 diabetes mellitus	1285.01	20.07	1875	273006	175357	110139061
Acute kidney injury	1229.91	20.07	92	274789	635338	109679080
Contraindicated product administered	1229.81	20.07	2209	272672	246058	110068360
Maternal exposure during pregnancy	1222.10	20.07	2236	272645	252647	110061771
Hypersensitivity	1209.89	20.07	2922	271959	401076	109913342
Joint swelling	1146.70	20.07	3031	271850	439814	109874604
Psoriatic arthropathy	1107.77	20.07	1853	273028	194908	110119510
Swollen joint count increased	1085.09	20.07	1184	273697	82477	110231941
Stomatitis	1050.47	20.07	2170	272711	268072	110046346
Ill-defined disorder	1047.40	20.07	1597	273284	155256	110159162
Therapeutic product effect decreased	1022.33	20.07	2023	272858	242293	110072125
Blood cholesterol increased	960.71	20.07	1680	273201	183105	110131313
Fibromyalgia	955.77	20.07	1605	273276	169304	110145114
Injury	941.58	20.07	1627	273254	175638	110138780
Drug interaction	940.78	20.07	82	274799	500101	109814317
Anaemia	913.44	20.07	136	274745	546950	109767468
Lower respiratory tract infection	894.34	20.07	1909	272972	241197	110073221
Drug intolerance	878.12	20.07	2606	272275	403906	109910512
Facet joint syndrome	853.50	20.07	1126	273755	95702	110218716
Liver injury	852.21	20.07	1421	273460	148992	110165426
Lip dry	850.18	20.07	1143	273738	98940	110215478
Joint range of motion decreased	781.57	20.07	1218	273663	120614	110193804
Hypotension	766.22	20.07	181	274700	523668	109790750
Peripheral venous disease	730.21	20.07	971	273910	83146	110231272
Neutropenia	681.35	20.07	70	274811	374550	109939868
Mobility decreased	664.67	20.07	1675	273206	235747	110078671
Gastrointestinal disorder	657.64	20.07	1688	273193	240264	110074154
Treatment failure	607.16	20.07	1787	273094	275447	110038971
Death	606.05	20.07	509	274372	698360	109616058
Sinusitis	605.16	20.07	1865	273016	294823	110019595
C-reactive protein abnormal	598.36	20.07	1120	273761	128575	110185843
Toxicity to various agents	590.58	20.07	228	274653	480327	109834091
Bursitis	587.04	20.07	1112	273769	128806	110185612
Febrile neutropenia	576.45	20.07	59	274822	316708	109997710
Deep vein thrombosis postoperative	555.85	20.07	711	274170	58580	110255838
Night sweats	550.82	20.07	1102	273779	132881	110181537
Breast cancer stage III	545.35	20.07	818	274063	78299	110236119
Obesity	538.05	20.07	991	273890	112360	110202058
Wound infection	524.39	20.07	895	273986	95570	110218848
Sepsis	524.25	20.07	91	274790	327255	109987163
Musculoskeletal stiffness	503.29	20.07	1685	273196	278137	110036281
Grip strength decreased	493.87	20.07	787	274094	79387	110235031
Sleep disorder	487.91	20.07	1335	273546	197309	110117109
Osteoarthritis	487.64	20.07	1266	273615	181357	110133061
Product use issue	485.63	20.07	1790	273091	309905	110004513
Sciatica	473.15	20.07	835	274046	91564	110222854
Autoimmune disorder	459.81	20.07	683	274198	64800	110249618
Weight increased	455.51	20.07	2157	272724	417487	109896931
Nasopharyngitis	455.27	20.07	2064	272817	392297	109922121
Dry mouth	454.95	20.07	1307	273574	198641	110115777
Somnolence	454.30	20.07	93	274788	297356	110017062
Road traffic accident	445.75	20.07	887	273994	106511	110207907
Blepharospasm	442.23	20.07	611	274270	54240	110260178
Disease progression	439.93	20.07	47	274834	243987	110070431
Contusion	439.88	20.07	1428	273453	231933	110082485
Pancytopenia	433.03	20.07	21	274860	209592	110104826
Fall	431.95	20.07	519	274362	602963	109711455
Lower limb fracture	418.63	20.07	706	274175	74642	110239776
Constipation	416.33	20.07	184	274697	357602	109956816
Thrombocytopenia	416.20	20.07	173	274708	348712	109965706
Hypercholesterolaemia	408.36	20.07	776	274105	90061	110224357
Platelet count decreased	406.28	20.07	48	274833	230395	110084023
Onychomadesis	402.13	20.07	531	274350	45132	110269286
Live birth	401.99	20.07	663	274218	68821	110245597
Hip arthroplasty	401.74	20.07	589	274292	55224	110259194
Hypoaesthesia	401.66	20.07	1696	273185	312527	110001891
Cough	401.22	20.07	335	274546	461306	109853112
Wheezing	398.44	20.07	1467	273414	253763	110060655
Infection	397.47	20.07	1868	273013	360332	109954086
General physical health deterioration	395.71	20.07	2093	272788	423202	109891216
Hyponatraemia	394.68	20.07	41	274840	217612	110096806
Gait inability	390.58	20.07	971	273910	135405	110179013
Dehydration	390.09	20.07	106	274775	279405	110035013
Erythema	378.69	20.07	126	274755	291321	110023097
Inflammation	375.44	20.07	1195	273686	192043	110122375
Adjustment disorder with depressed mood	370.64	20.07	500	274381	43383	110271035
Adverse event	368.36	20.07	827	274054	107982	110206436
Renal impairment	367.58	20.07	26	274855	188419	110125999
Urinary tract infection	366.85	20.07	176	274705	326106	109988312
Peripheral swelling	366.02	20.07	1974	272907	402060	109912358
Renal failure	360.45	20.07	64	274817	226510	110087908
Dislocation of vertebra	356.91	20.07	490	274391	43231	110271187
Lung disorder	354.86	20.07	1119	273762	178928	110135490
Cardiac failure	351.67	20.07	31	274850	187595	110126823
Nail disorder	342.14	20.07	558	274323	57377	110257041
Haemoglobin decreased	340.22	20.07	98	274783	248629	110065789
Back pain	327.49	20.07	265	274616	370731	109943687
Intentional product use issue	324.40	20.07	1348	273533	246558	110067860
Nausea	322.90	20.07	1781	273100	1233909	109080509
Blood creatinine increased	322.60	20.07	38	274843	182851	110131567
X-ray abnormal	321.44	20.07	434	274447	37683	110276735
Multiple organ dysfunction syndrome	320.55	20.07	13	274868	151697	110162721
Bradycardia	316.69	20.07	17	274864	155500	110158918
Seizure	314.06	20.07	81	274800	221104	110093314
Malignant neoplasm progression	313.62	20.07	34	274847	174533	110139885
Rash	312.49	20.07	3264	271617	817700	109496718
Knee arthroplasty	310.81	20.07	570	274311	64378	110250040
Alanine aminotransferase increased	310.14	20.07	44	274837	183729	110130689
Blood pressure increased	308.24	20.07	128	274753	258245	110056173
Retinitis	308.20	20.07	391	274490	31936	110282482
White blood cell count decreased	307.14	20.07	94	274787	229296	110085122
Onychomycosis	305.76	20.07	426	274455	38105	110276313
Prescribed overdose	304.66	20.07	673	274208	86908	110227510
Atrial fibrillation	293.55	20.07	102	274779	229540	110084878
Taste disorder	290.65	20.07	556	274325	64831	110249587
Urticaria	290.03	20.07	1560	273321	317297	109997121
C-reactive protein	287.81	20.07	366	274515	29965	110284453
Product dose omission issue	287.53	20.07	227	274654	321555	109992863
Syncope	285.96	20.07	75	274806	202461	110111957
Hyperkalaemia	282.39	20.07	13	274868	135783	110178635
Confusional state	278.95	20.07	2057	272824	466623	109847795
Musculoskeletal pain	278.79	20.07	1044	273837	181979	110132439
Lupus vulgaris	276.94	20.07	380	274501	33503	110280915
Aspartate aminotransferase increased	270.56	20.07	38	274843	159898	110154520
Pain	267.06	20.07	3579	271302	951376	109363042
Respiratory failure	262.83	20.07	103	274778	215229	110099189
Rhabdomyolysis	262.45	20.07	8	274873	120393	110194025
Myocardial infarction	262.07	20.07	76	274805	192007	110122411
Drug abuse	261.56	20.07	60	274821	177351	110137067
Off label use	258.39	20.07	2437	272444	1497748	108816670
Tremor	258.17	20.07	90	274791	202142	110112276
Neuropathy peripheral	257.68	20.07	64	274817	179213	110135205
Hyperhidrosis	252.08	20.07	76	274805	187222	110127196
Cardiac arrest	248.70	20.07	89	274792	196664	110117754
Anti-cyclic citrullinated peptide antibody	245.61	20.07	275	274606	19689	110294729
Completed suicide	242.89	20.07	151	274730	242230	110072188
Cerebrovascular accident	234.30	20.07	79	274802	181205	110133213
Exposure during pregnancy	233.68	20.07	929	273952	166495	110147923
Migraine	232.82	20.07	944	273937	170708	110143710
Hypoglycaemia	232.36	20.07	14	274867	116090	110198328
COVID-19	231.61	20.07	163	274718	244897	110069521
Pregnancy	231.60	20.07	438	274443	50629	110263789
Diarrhoea	228.53	20.07	1778	273103	1137727	109176691
Exostosis	228.35	20.07	410	274471	45546	110268872
Product quality issue	226.10	20.07	555	274326	76744	110237674
Septic shock	224.91	20.07	57	274824	157471	110156947
Gastrointestinal haemorrhage	224.85	20.07	66	274815	165452	110148966
Pulmonary embolism	224.21	20.07	127	274754	214347	110100071
Myalgia	222.18	20.07	139	274742	222242	110092176
Inappropriate schedule of product administration	219.54	20.07	116	274765	203521	110110897
Injection site pain	218.95	20.07	84	274797	177838	110136580
Myelosuppression	218.51	20.07	3	274878	94337	110220081
Lupus-like syndrome	218.31	20.07	376	274505	40416	110274002
Neutrophil count decreased	216.08	20.07	24	274857	120917	110193501
Memory impairment	215.91	20.07	1016	273865	195928	110118490
Oedema	215.61	20.07	1063	273818	208913	110105505
Interstitial lung disease	211.72	20.07	44	274837	139290	110175128
Bone erosion	210.63	20.07	398	274483	45973	110268445
Oxygen saturation decreased	208.89	20.07	65	274816	156917	110157501
Rheumatoid arthritis	208.70	20.07	1367	273514	298246	110016172
Coma	206.58	20.07	25	274856	117844	110196574
Hypokalaemia	204.06	20.07	99	274782	182349	110132069
Blood glucose increased	203.06	20.07	41	274840	132455	110181963
Metabolic acidosis	202.76	20.07	11	274870	99733	110214685
Depressed level of consciousness	201.31	20.07	22	274859	112256	110202162
Chest discomfort	199.57	20.07	91	274790	173757	110140661
Lactic acidosis	199.32	20.07	7	274874	92804	110221614
Electrocardiogram QT prolonged	198.83	20.07	20	274861	108940	110205478
Laryngitis	196.35	20.07	367	274514	42044	110272374
Hepatic function abnormal	194.37	20.07	6	274875	89289	110225129
Intentional overdose	192.94	20.07	46	274835	132455	110181963
Liver disorder	191.85	20.07	781	274100	141462	110172956
Pulmonary fibrosis	190.74	20.07	623	274258	101419	110212999
Pleural effusion	190.42	20.07	102	274779	177607	110136811
Leukopenia	190.26	20.07	66	274815	148725	110165693
Mucosal inflammation	188.21	20.07	13	274868	96128	110218290
Herpes zoster	187.46	20.07	24	274857	108355	110206063
Influenza	185.73	20.07	94	274787	169007	110145411
Blood pressure decreased	184.09	20.07	32	274849	115059	110199359
Back injury	182.94	20.07	380	274501	47019	110267399
Chills	179.74	20.07	127	274754	190453	110123965
Ascites	174.77	20.07	15	274866	92793	110221625
Loss of consciousness	172.12	20.07	141	274740	196165	110118253
Heart rate increased	171.89	20.07	71	274810	143763	110170655
Prescribed underdose	170.88	20.07	449	274432	64725	110249693
Suicide attempt	169.26	20.07	27	274854	103367	110211051
Drug reaction with eosinophilia and systemic symptoms	167.03	20.07	9	274872	82086	110232332
Epistaxis	166.40	20.07	58	274823	130314	110184104
Feeling abnormal	160.67	20.07	128	274753	180583	110133835
Angioedema	160.62	20.07	26	274855	98474	110215944
Blood pressure systolic increased	160.22	20.07	12	274869	82979	110231439
Cytokine release syndrome	159.61	20.07	3	274878	70303	110244115
Blood bilirubin increased	158.83	20.07	7	274874	75965	110238453
Palpitations	158.34	20.07	100	274781	159112	110155306
Balance disorder	157.35	20.07	47	274834	116513	110197905
Dysphagia	156.19	20.07	94	274787	153506	110160912
Vertigo	155.79	20.07	17	274864	86853	110227565
Maternal exposure timing unspecified	152.97	20.07	223	274658	20790	110293628
Cellulitis	152.54	20.07	61	274820	125955	110188463
Porphyria acute	152.53	20.07	210	274671	18570	110295848
Epilepsy	151.15	20.07	570	274311	99639	110214779
Pneumonia	147.78	20.07	1430	273451	875284	109439134
Abdominal pain upper	144.71	20.07	1414	273467	347697	109966721
Product label confusion	144.26	20.07	226	274655	22451	110291967
Haemorrhage	144.06	20.07	43	274838	106649	110207769
Finger deformity	142.88	20.07	278	274603	32814	110281604
Rash maculo-papular	142.53	20.07	11	274870	74211	110240207
Foot deformity	141.66	20.07	348	274533	48132	110266286
Agitation	141.37	20.07	52	274829	112999	110201419
Hyperglycaemia	139.78	20.07	22	274859	85068	110229350
Vision blurred	139.77	20.07	73	274808	128949	110185469
Thrombosis	139.26	20.07	48	274833	108614	110205804
Heart rate decreased	139.15	20.07	20	274861	82736	110231682
Agranulocytosis	138.75	20.07	3	274878	61757	110252661
Oropharyngeal pain	138.65	20.07	82	274799	135194	110179224
Haematochezia	138.08	20.07	57	274824	115467	110198951
Encephalopathy	137.67	20.07	19	274862	81036	110233382
Blood creatine phosphokinase increased	137.09	20.07	12	274869	73065	110241353
Cardiac failure congestive	135.44	20.07	106	274775	150894	110163524
Dysarthria	135.39	20.07	23	274858	84098	110230320
Dyspnoea exertional	135.04	20.07	45	274836	104015	110210403
Hypoxia	134.88	20.07	77	274804	129438	110184980
Stress	134.21	20.07	47	274834	105301	110209117
Pulmonary oedema	133.33	20.07	42	274839	100617	110213801
Flushing	132.96	20.07	47	274834	104689	110209729
Adverse drug reaction	132.46	20.07	567	274314	104992	110209426
Cognitive disorder	132.18	20.07	28	274853	87483	110226935
Wrong technique in product usage process	131.83	20.07	28	274853	87320	110227098
Disorientation	131.51	20.07	12	274869	70659	110243759
Cardio-respiratory arrest	130.81	20.07	62	274819	115774	110198644
Hepatic failure	129.73	20.07	11	274870	68728	110245690
Breast cancer stage II	129.36	20.07	239	274642	27136	110287282
Hepatotoxicity	128.83	20.07	7	274874	63393	110251025
Skin exfoliation	128.45	20.07	30	274851	87621	110226797
Blood pressure fluctuation	128.36	20.07	17	274864	74807	110239611
Colitis	128.05	20.07	47	274834	102276	110212142
Lymphocyte count decreased	127.74	20.07	3	274878	57240	110257178
Incorrect dose administered	127.37	20.07	49	274832	103592	110210826
Gamma-glutamyltransferase increased	127.02	20.07	6	274875	61303	110253115
Transaminases increased	125.76	20.07	8	274873	63382	110251036
Injection site erythema	125.26	20.07	39	274842	94137	110220281
Altered state of consciousness	124.96	20.07	4	274877	57622	110256796
Suicidal ideation	124.77	20.07	39	274842	93898	110220520
Walking aid user	123.65	20.07	223	274658	24852	110289566
Neoplasm progression	122.84	20.07	10	274871	64585	110249833
Drug ineffective for unapproved indication	122.49	20.07	51	274830	102787	110211631
Melaena	121.92	20.07	14	274867	68743	110245675
Tachycardia	121.34	20.07	237	274644	226408	110088010
Abdominal pain	120.76	20.07	763	274118	512226	109802192
Pneumonia aspiration	120.65	20.07	27	274854	81206	110233212
Tubulointerstitial nephritis	120.54	20.07	3	274878	54281	110260137
Pancreatitis acute	118.41	20.07	8	274873	60266	110254152
Deep vein thrombosis	118.29	20.07	104	274777	139783	110174635
Drug hypersensitivity	118.24	20.07	1682	273199	452408	109862010
Cytomegalovirus infection	117.27	20.07	4	274877	54440	110259978
Hypothyroidism	117.17	20.07	20	274861	72879	110241539
Seronegative arthritis	117.17	20.07	154	274727	13023	110301395
Coeliac disease	116.76	20.07	301	274580	42886	110271532
Haematuria	116.62	20.07	31	274850	82974	110231444
Cerebral haemorrhage	115.77	20.07	13	274868	64955	110249463
Hepatic cirrhosis	114.97	20.07	400	274481	67226	110247192
Sedation	114.49	20.07	18	274863	69665	110244753
Liver function test abnormal	112.86	20.07	18	274863	68932	110245486
Joint dislocation	112.44	20.07	257	274624	33933	110280485
Lethargy	112.11	20.07	46	274835	93530	110220888
International normalised ratio increased	111.76	20.07	38	274843	86734	110227684
Hepatocellular injury	111.69	20.07	3	274878	50639	110263779
Hypertension	111.13	20.07	1833	273048	508251	109806167
Acute myocardial infarction	110.88	20.07	35	274846	83742	110230676
Blood alkaline phosphatase increased	110.68	20.07	21	274860	70914	110243504
Dry skin	109.27	20.07	66	274815	107587	110206831
Cardiogenic shock	108.69	20.07	9	274872	57329	110257089
Pneumonitis	108.63	20.07	28	274853	76503	110237915
Influenza like illness	108.31	20.07	42	274839	88370	110226048
Overdose	108.22	20.07	265	274616	233529	110080889
Hypomagnesaemia	107.78	20.07	12	274869	60358	110254060
Jaundice	107.74	20.07	11	274870	59225	110255193
Cerebral infarction	107.63	20.07	5	274876	51833	110262585
Product prescribing error	106.42	20.07	5	274876	51326	110263092
Eosinophilia	104.75	20.07	11	274870	57925	110256493
Orthostatic hypotension	104.68	20.07	19	274862	66230	110248188
Anaphylactic shock	103.78	20.07	6	274875	51540	110262878
Full blood count abnormal	103.01	20.07	10	274871	56042	110258376
Liver function test increased	102.27	20.07	464	274417	88084	110226334
Muscle spasms	102.03	20.07	1099	273782	277058	110037360
Acute respiratory distress syndrome	101.82	20.07	8	274873	53190	110261228
Eczema	101.56	20.07	27	274854	72266	110242152
Hallucination	100.44	20.07	64	274817	101368	110213050
Swelling face	100.33	20.07	52	274829	92269	110222149
Drug eruption	100.14	20.07	9	274872	53650	110260768
Haematemesis	100.04	20.07	14	274867	59094	110255324
Arthralgia	99.35	20.07	2588	272293	777044	109537374
Serotonin syndrome	97.82	20.07	15	274866	59138	110255280
Weight decreased	97.31	20.07	722	274159	467335	109847083
Cataract	96.97	20.07	38	274843	79447	110234971
Cystitis	95.98	20.07	23	274858	66013	110248405
Skin ulcer	94.83	20.07	21	274860	63624	110250794
C-reactive protein increased	94.34	20.07	891	273990	217028	110097390
Pallor	94.11	20.07	14	274867	56453	110257965
Intentional product misuse	94.08	20.07	115	274766	132789	110181629
Dyspepsia	94.04	20.07	803	274078	190162	110124256
Transient ischaemic attack	93.55	20.07	22	274859	63960	110250458
Blood lactate dehydrogenase increased	92.95	20.07	4	274877	44330	110270088
Paraesthesia	92.52	20.07	1073	273808	275448	110038970
Angina pectoris	91.92	20.07	21	274860	62274	110252144
Neurotoxicity	91.27	20.07	3	274878	42204	110272214
Aphasia	90.92	20.07	18	274863	58979	110255439
Respiratory distress	90.74	20.07	29	274852	68845	110245573
Red blood cell count decreased	90.03	20.07	26	274855	65897	110248521
Stevens-Johnson syndrome	89.91	20.07	7	274874	46894	110267524
Haematoma	89.78	20.07	18	274863	58458	110255960
Depressed mood	88.73	20.07	21	274860	60788	110253630
Amnesia	88.49	20.07	505	274376	104903	110209515
Bacteraemia	88.30	20.07	4	274877	42386	110272032
Swollen tongue	87.77	20.07	21	274860	60341	110254077
Diabetes mellitus	87.56	20.07	71	274810	99310	110215108
Lymphadenopathy	87.50	20.07	25	274856	63810	110250608
Chronic kidney disease	87.42	20.07	40	274841	76251	110238167
Osteonecrosis of jaw	87.11	20.07	9	274872	48008	110266410
Mental status changes	87.09	20.07	40	274841	76082	110238336
Hypercalcaemia	86.60	20.07	8	274873	46649	110267769
Bone pain	86.57	20.07	27	274854	65106	110249312
Lymphopenia	86.35	20.07	3	274878	40167	110274251
Blood urea increased	86.32	20.07	16	274865	54941	110259477
Pneumocystis jirovecii pneumonia	85.96	20.07	5	274876	42730	110271688
Haemoptysis	85.60	20.07	35	274846	71319	110243099
Dyskinesia	85.18	20.07	13	274868	51433	110262985
Ear infection	84.98	20.07	345	274536	62387	110252031
Disturbance in attention	83.66	20.07	25	274856	61970	110252448
Generalised tonic-clonic seizure	83.60	20.07	17	274864	54663	110259755
Hypophagia	83.35	20.07	15	274866	52611	110261807
Cardiac disorder	82.84	20.07	43	274838	76237	110238181
Ventricular fibrillation	82.59	20.07	5	274876	41308	110273110
Disseminated intravascular coagulation	82.53	20.07	5	274876	41281	110273137
Dysphonia	82.17	20.07	43	274838	75886	110238532
Arrhythmia	82.06	20.07	35	274846	69540	110244878
Haematocrit decreased	81.67	20.07	31	274850	66086	110248332
Subcutaneous drug absorption impaired	81.63	20.07	98	274783	7561	110306857
Coronary artery disease	81.51	20.07	38	274843	71652	110242766
Shock	81.23	20.07	17	274864	53571	110260847
Basal cell carcinoma	80.81	20.07	9	274872	45261	110269157
Tinnitus	80.63	20.07	25	274856	60515	110253903
Mouth ulceration	80.08	20.07	12	274869	48126	110266292
Ventricular tachycardia	79.75	20.07	14	274867	49995	110264423
Staphylococcal infection	79.64	20.07	37	274844	69907	110244511
Presyncope	79.48	20.07	13	274868	48874	110265544
Speech disorder	79.22	20.07	27	274854	61542	110252876
Drug level increased	79.14	20.07	12	274869	47707	110266711
Drug tolerance decreased	78.67	20.07	196	274685	27344	110287074
Plasma cell myeloma	78.59	20.07	29	274852	62907	110251511
Acute myeloid leukaemia	78.08	20.07	4	274877	38106	110276312
Injection site swelling	77.96	20.07	28	274853	61762	110252656
Ulcer haemorrhage	76.82	20.07	172	274709	22399	110292019
Intentional self-injury	76.46	20.07	4	274877	37425	110276993
Ejection fraction decreased	75.90	20.07	7	274874	40873	110273545
Ulcer	75.89	20.07	9	274872	43107	110271311
Pericardial effusion	75.54	20.07	24	274857	57193	110257225
Nephrolithiasis	75.43	20.07	35	274846	66177	110248241
Rash erythematous	75.21	20.07	56	274825	81776	110232642
Burning sensation	75.19	20.07	39	274842	69173	110245245
Red blood cell sedimentation rate increased	75.08	20.07	389	274492	77913	110236505
Dysuria	74.80	20.07	28	274853	60203	110254215
Anaphylactic reaction	74.65	20.07	105	274776	114195	110200223
Infusion site reaction	74.45	20.07	147	274734	17535	110296883
Multiple sclerosis relapse	74.00	20.07	17	274864	50223	110264195
Restlessness	73.56	20.07	24	274857	56235	110258183
Diabetic ketoacidosis	73.49	20.07	9	274872	42049	110272369
Therapy interrupted	73.10	20.07	17	274864	49805	110264613
Skin lesion	73.06	20.07	19	274862	51612	110262806
Hepatic steatosis	72.97	20.07	16	274865	48815	110265603
Abortion spontaneous	72.18	20.07	3	274878	34279	110280139
Proteinuria	71.32	20.07	8	274873	40010	110274408
Lip swelling	71.02	20.07	19	274862	50648	110263770
Localised infection	70.99	20.07	11	274870	43037	110271381
Dysgeusia	70.89	20.07	43	274838	69942	110244476
Clostridium difficile colitis	70.38	20.07	12	274869	43766	110270652
Disability	70.01	20.07	199	274682	30024	110284394
Therapy non-responder	69.97	20.07	647	274234	156660	110157758
Acute respiratory failure	69.82	20.07	51	274830	75209	110239209
Upper gastrointestinal haemorrhage	69.82	20.07	19	274862	50077	110264341
Blood pressure diastolic decreased	69.80	20.07	5	274876	35880	110278538
Drug dependence	69.66	20.07	19	274862	50001	110264417
Aggression	69.49	20.07	30	274851	59180	110255238
Ischaemic stroke	69.30	20.07	10	274871	41253	110273165
Hot flush	69.12	20.07	39	274842	65997	110248421
Myoclonus	69.11	20.07	3	274878	32995	110281423
Swollen joint count	68.95	20.07	96	274785	8578	110305840
Urinary retention	68.94	20.07	44	274837	69639	110244779
Palmar-plantar erythrodysaesthesia syndrome	68.77	20.07	10	274871	41015	110273403
Adverse reaction	68.69	20.07	195	274686	29399	110285019
Prostate cancer	68.43	20.07	7	274874	37634	110276784
Gastritis	68.32	20.07	24	274857	53675	110260743
Pulmonary hypertension	68.02	20.07	26	274855	55194	110259224
Device related infection	67.73	20.07	9	274872	39510	110274908
Osteonecrosis	67.71	20.07	4	274877	33737	110280681
Dyspnoea	67.11	20.07	2169	272712	1104703	109209715
Neutrophil count increased	66.91	20.07	5	274876	34647	110279771
Leukocytosis	66.88	20.07	25	274856	53803	110260615
Clostridium difficile infection	66.83	20.07	23	274858	52106	110262312
Body temperature decreased	66.80	20.07	7	274874	36928	110277490
Respiratory depression	66.72	20.07	3	274878	31998	110282420
Renal disorder	66.68	20.07	20	274861	49459	110264959
Hypocalcaemia	66.44	20.07	40	274841	65326	110249092
Hemiparesis	66.39	20.07	14	274867	43889	110270529
Nightmare	66.25	20.07	9	274872	38854	110275564
Coagulopathy	66.24	20.07	11	274870	40900	110273518
Illness	66.01	20.07	64	274817	82107	110232311
Sopor	65.91	20.07	7	274874	36539	110277879
Skin discolouration	65.78	20.07	20	274861	49026	110265392
Status epilepticus	65.69	20.07	3	274878	31568	110282850
Myelodysplastic syndrome	65.54	20.07	8	274873	37476	110276942
Rhinorrhoea	65.38	20.07	96	274785	102570	110211848
Obstructive airways disorder	65.27	20.07	17	274864	46132	110268286
Peritonitis	65.02	20.07	4	274877	32603	110281815
Diverticulitis	64.61	20.07	26	274855	53496	110260922
Electrolyte imbalance	64.51	20.07	8	274873	37020	110277398
Therapy cessation	64.45	20.07	16	274865	44841	110269577
Eye pain	64.41	20.07	22	274859	50077	110264341
Psychotic disorder	64.40	20.07	23	274858	50914	110263504
Neutropenic sepsis	63.72	20.07	3	274878	30743	110283675
Polyneuropathy	63.62	20.07	4	274877	32008	110282410
Hypophosphataemia	63.47	20.07	5	274876	33177	110281241
Premature delivery	63.45	20.07	3	274878	30629	110283789
Injection site bruising	63.37	20.07	24	274857	51239	110263179
Hallucination, visual	63.35	20.07	11	274870	39594	110274824
Metastases to liver	63.25	20.07	7	274874	35379	110279039
Acute hepatic failure	63.24	20.07	8	274873	36460	110277958
Cytopenia	62.22	20.07	3	274878	30113	110284305
Diplopia	62.05	20.07	14	274867	41880	110272538
Candida infection	61.86	20.07	21	274860	47988	110266430
Gastroenteritis	61.57	20.07	11	274870	38789	110275629
Subarachnoid haemorrhage	61.23	20.07	3	274878	29699	110284719
Neuralgia	61.10	20.07	22	274859	48456	110265962
Blindness	60.63	20.07	9	274872	36350	110278068
Urosepsis	60.47	20.07	4	274877	30671	110283747
Hyperbilirubinaemia	60.46	20.07	4	274877	30667	110283751
Nervous system disorder	60.07	20.07	5	274876	31716	110282702
Sinus tachycardia	59.93	20.07	18	274863	44475	110269943
Femur fracture	59.88	20.07	18	274863	44451	110269967
Posterior reversible encephalopathy syndrome	59.77	20.07	7	274874	33854	110280564
Gastric ulcer	59.62	20.07	13	274868	39814	110274604
Haemorrhage intracranial	59.48	20.07	3	274878	28966	110285452
Glomerular filtration rate decreased	59.45	20.07	3	274878	28953	110285465
Fungal infection	59.21	20.07	26	274855	50780	110263638
Visual acuity reduced	58.44	20.07	6	274875	32167	110282251
Hepatic encephalopathy	57.78	20.07	3	274878	28253	110286165
Unevaluable event	57.77	20.07	38	274843	59189	110255229
Cholelithiasis	57.52	20.07	44	274837	63378	110251040
Blood calcium decreased	57.24	20.07	10	274871	35835	110278583
Underdose	57.00	20.07	310	274571	63244	110251174
Tachypnoea	56.70	20.07	14	274867	39381	110275037
Grip strength	56.62	20.07	90	274791	9051	110305367
Cardiomyopathy	56.59	20.07	8	274873	33517	110280901
Productive cough	56.53	20.07	125	274756	114180	110200238
Irritability	56.46	20.07	24	274857	47785	110266633
Gastrooesophageal reflux disease	56.04	20.07	689	274192	179287	110135131
Toxic epidermal necrolysis	55.87	20.07	36	274845	56691	110257727
Joint stiffness	55.67	20.07	321	274560	66922	110247496
Injection site pruritus	55.50	20.07	29	274852	51229	110263189
Appendicitis	55.27	20.07	4	274877	28460	110285958
Vasculitis	55.16	20.07	11	274870	35862	110278556
Blood potassium decreased	55.16	20.07	33	274848	54081	110260337
Acne	54.30	20.07	9	274872	33511	110280907
Throat irritation	54.10	20.07	33	274848	53519	110260899
COVID-19 pneumonia	53.85	20.07	13	274868	37130	110277288
Hypervolaemia	53.53	20.07	28	274853	49432	110264986
Viral infection	53.33	20.07	33	274848	53106	110261312
Troponin increased	52.92	20.07	6	274875	29760	110284658
Normal newborn	52.51	20.07	146	274735	21750	110292668
Malnutrition	52.49	20.07	4	274877	27275	110287143
Subdural haematoma	52.38	20.07	13	274868	36441	110277977
Spondylitis	52.33	20.07	98	274783	11240	110303178
Renal tubular necrosis	52.09	20.07	7	274874	30468	110283950
Nail operation	52.03	20.07	39	274842	1655	110312763
Face oedema	52.02	20.07	10	274871	33459	110280959
Pruritus	52.00	20.07	1849	273032	579711	109734707
Neoplasm malignant	51.93	20.07	14	274867	37129	110277289
Pneumothorax	51.85	20.07	12	274869	35273	110279145
Withdrawal syndrome	51.79	20.07	8	274873	31372	110283046
Head injury	51.76	20.07	21	274860	42996	110271422
Dry eye	51.50	20.07	38	274843	55755	110258663
Brain oedema	51.16	20.07	8	274873	31090	110283328
Hypoalbuminaemia	51.12	20.07	6	274875	28968	110285450
Injection site haemorrhage	51.05	20.07	10	274871	33018	110281400
Hypocholesterolaemia	50.94	20.07	71	274810	6350	110308068
Unresponsive to stimuli	50.87	20.07	50	274831	63740	110250678
Device expulsion	50.70	20.07	8	274873	30883	110283535
Abdominal pain lower	50.37	20.07	15	274866	37268	110277150
Therapeutic response shortened	50.08	20.07	7	274874	29576	110284842
Sinus bradycardia	49.85	20.07	7	274874	29476	110284942
Accidental overdose	49.56	20.07	34	274847	51800	110262618
Fracture	49.55	20.07	3	274878	24785	110289633
Labelled drug-drug interaction medication error	49.45	20.07	7	274874	29295	110285123
Gout	48.88	20.07	15	274866	36551	110277867
Abnormal behaviour	48.72	20.07	18	274863	39021	110275397
Hepatic enzyme	48.49	20.07	62	274819	5101	110309317
Product administration error	48.44	20.07	16	274865	37201	110277217
Mental disorder	48.22	20.07	18	274863	38773	110275645
Ileus	48.14	20.07	9	274872	30720	110283698
Dementia	48.10	20.07	10	274871	31663	110282755
Generalised oedema	48.09	20.07	9	274872	30695	110283723
Oral herpes	47.87	20.07	15	274866	36065	110278353
Insomnia	47.81	20.07	1204	273677	359386	109955032
Respiratory arrest	47.30	20.07	45	274836	58254	110256164
Escherichia infection	47.26	20.07	3	274878	23813	110290605
Progressive multifocal leukoencephalopathy	47.07	20.07	4	274877	24952	110289466
Dysstasia	46.94	20.07	12	274869	32974	110281444
Delirium	46.93	20.07	528	274353	134497	110179921
General symptom	46.62	20.07	81	274800	8765	110305653
Device issue	46.46	20.07	14	274867	34521	110279897
Pollakiuria	46.40	20.07	26	274855	44169	110270249
Extrapyramidal disorder	46.21	20.07	8	274873	28859	110285559
Breast cancer	46.07	20.07	19	274862	38523	110275895
Photosensitivity reaction	45.89	20.07	5	274876	25584	110288834
Joint injury	45.77	20.07	21	274860	39973	110274445
Intestinal obstruction	45.68	20.07	39	274842	53188	110261230
Anuria	45.64	20.07	4	274877	24337	110290081
Blood potassium increased	45.61	20.07	13	274868	33236	110281182
Osteomyelitis	45.47	20.07	17	274864	36583	110277835
Metastases to bone	45.44	20.07	11	274870	31361	110283057
Hypothermia	45.05	20.07	6	274875	26296	110288122
Urinary incontinence	44.97	20.07	33	274848	48554	110265864
Hemiplegia	44.82	20.07	3	274878	22779	110291639
Rash macular	44.76	20.07	20	274861	38666	110275752
Disease recurrence	44.72	20.07	51	274830	60733	110253685
Rash pruritic	44.69	20.07	112	274769	97957	110216461
Mental impairment	44.48	20.07	3	274878	22636	110291782
Eating disorder	44.35	20.07	11	274870	30847	110283571
Muscle twitching	44.34	20.07	10	274871	29925	110284493
Bacterial infection	44.28	20.07	30	274851	46006	110268412
Heart rate irregular	44.15	20.07	15	274866	34259	110280159
Immune thrombocytopenia	44.14	20.07	3	274878	22491	110291927
Rales	43.95	20.07	5	274876	24734	110289684
Dystonia	43.93	20.07	6	274875	25799	110288619
Cyanosis	43.93	20.07	10	274871	29731	110284687
Accidental exposure to product	43.70	20.07	36	274845	49972	110264446
Bronchiectasis	43.61	20.07	18	274863	36475	110277943
Faeces discoloured	43.48	20.07	15	274866	33933	110280485
Motor dysfunction	43.19	20.07	5	274876	24401	110290017
Abscess	43.13	20.07	8	274873	27461	110286957
Skin laceration	43.08	20.07	15	274866	33738	110280680
Breath sounds abnormal	43.03	20.07	6	274875	25398	110289020
Schizophrenia	42.57	20.07	3	274878	21823	110292595
Hypokinesia	42.57	20.07	3	274878	21823	110292595
Injection site reaction	42.49	20.07	372	274509	88698	110225720
Muscle rigidity	42.34	20.07	5	274876	24026	110290392
Hypovolaemia	42.21	20.07	3	274878	21671	110292747
Pain in jaw	42.11	20.07	39	274842	51138	110263280
Pulmonary mass	42.05	20.07	20	274861	37281	110277137
Asthma	42.00	20.07	864	274017	249427	110064991
Feeling cold	41.86	20.07	16	274865	33971	110280447
Skin haemorrhage	41.73	20.07	6	274875	24821	110289597
Small intestinal obstruction	41.66	20.07	14	274867	32199	110282219
Feeding disorder	41.48	20.07	3	274878	21359	110293059
Flatulence	41.44	20.07	41	274840	52108	110262310
Blood albumin decreased	41.44	20.07	9	274872	27643	110286775
Neck pain	41.23	20.07	478	274403	122652	110191766
Pustular psoriasis	41.17	20.07	99	274782	13506	110300912
Splenomegaly	40.99	20.07	6	274875	24492	110289926
Surgery	40.93	20.07	26	274855	41257	110273161
Eosinophil count increased	40.77	20.07	3	274878	21055	110293363
Purpura	40.75	20.07	6	274875	24382	110290036
Device dislocation	40.62	20.07	14	274867	31690	110282728
Intestinal perforation	40.50	20.07	3	274878	20941	110293477
Panic attack	40.28	20.07	11	274870	28929	110285489
Product substitution issue	40.13	20.07	5	274876	23056	110291362
Cardiac failure acute	40.05	20.07	6	274875	24072	110290346
Ocular hyperaemia	39.98	20.07	24	274857	39262	110275156
Lung neoplasm malignant	39.94	20.07	17	274864	33825	110280593
Skin disorder	39.91	20.07	29	274852	42884	110271534
Pseudomonas infection	39.89	20.07	10	274871	27843	110286575
Drug ineffective	39.77	20.07	3248	271633	1517292	108797126
Limb injury	39.71	20.07	22	274859	37614	110276804
Metastases to central nervous system	39.58	20.07	5	274876	22812	110291606
Blood test abnormal	39.47	20.07	11	274870	28543	110285875
Medication error	39.37	20.07	418	274463	104948	110209470
Myocardial ischaemia	39.36	20.07	9	274872	26675	110287743
Chromaturia	39.32	20.07	12	274869	29348	110285070
Blood uric acid increased	39.14	20.07	4	274877	21525	110292893
Skin necrosis	39.10	20.07	4	274877	21508	110292910
Overlap syndrome	38.97	20.07	76	274805	8983	110305435
Hepatomegaly	38.88	20.07	4	274877	21410	110293008
Impaired work ability	38.79	20.07	9	274872	26410	110288008
Chronic obstructive pulmonary disease	38.72	20.07	140	274741	109018	110205400
Atrioventricular block complete	38.49	20.07	3	274878	20079	110294339
Hypertensive crisis	38.48	20.07	7	274874	24365	110290053
Hypogammaglobulinaemia	38.47	20.07	3	274878	20073	110294345
Klebsiella infection	38.31	20.07	3	274878	20006	110294412
Pyelonephritis	38.29	20.07	8	274873	25242	110289176
Coordination abnormal	38.24	20.07	8	274873	25220	110289198
Rib fracture	38.23	20.07	18	274863	33752	110280666
Erythema multiforme	38.15	20.07	4	274877	21093	110293325
Osteoporosis	38.01	20.07	357	274524	86795	110227623
Urine output decreased	38.00	20.07	3	274878	19873	110294545
Hypoacusis	37.97	20.07	20	274861	35171	110279247
Hip fracture	37.89	20.07	20	274861	35131	110279287
Drug withdrawal syndrome	37.68	20.07	24	274857	38030	110276388
Nasal congestion	37.61	20.07	122	274759	98160	110216258
Penile abscess	37.50	20.07	14	274867	132	110314286
Sudden infant death syndrome	37.45	20.07	18	274863	331	110314087
Rash vesicular	37.43	20.07	100	274781	14552	110299866
Mass	37.43	20.07	3	274878	19627	110294791
Pulmonary arterial hypertension	37.43	20.07	17	274864	32551	110281867
Ataxia	37.38	20.07	14	274867	30094	110284324
Delusion	37.12	20.07	7	274874	23748	110290670
Cardiovascular disorder	37.11	20.07	6	274875	22754	110291664
Kidney infection	37.03	20.07	9	274872	25590	110288828
Cardiac murmur	36.94	20.07	8	274873	24620	110289798
Poor venous access	36.71	20.07	8	274873	24514	110289904
Sensory loss	36.50	20.07	5	274876	21452	110292966
Sudden death	36.44	20.07	8	274873	24387	110290031
Activated partial thromboplastin time prolonged	36.24	20.07	6	274875	22362	110292056
Oesophagitis	36.24	20.07	13	274868	28702	110285716
Respiratory rate increased	35.93	20.07	9	274872	25074	110289344
Mydriasis	35.78	20.07	6	274875	22151	110292267
Acute coronary syndrome	35.72	20.07	7	274874	23105	110291313
Food allergy	35.52	20.07	4	274877	19944	110294474
Hepatitis acute	35.42	20.07	3	274878	18763	110295655
Miosis	35.39	20.07	6	274875	21977	110292441
Vomiting	35.34	20.07	1877	273004	908798	109405620
Atelectasis	35.21	20.07	24	274857	36688	110277730
Hallucination, auditory	34.97	20.07	11	274870	26386	110288032
Injection site mass	34.93	20.07	9	274872	24604	110289814
Uveitis	34.79	20.07	6	274875	21704	110292714
Squamous cell carcinoma	34.71	20.07	3	274878	18460	110295958
Dermatitis	34.46	20.07	13	274868	27824	110286594
Acidosis	34.45	20.07	7	274874	22524	110291894
Mitral valve incompetence	34.43	20.07	20	274861	33309	110281109
Bronchospasm	34.42	20.07	16	274865	30223	110284195
Treatment noncompliance	34.32	20.07	82	274799	72908	110241510
Tendonitis	34.32	20.07	11	274870	26072	110288346
Blood sodium decreased	34.22	20.07	27	274854	38292	110276126
Micturition urgency	34.08	20.07	4	274877	19316	110295102
Cholecystitis	33.91	20.07	11	274870	25871	110288547
Psychomotor hyperactivity	33.85	20.07	5	274876	20272	110294146
Eye pruritus	33.38	20.07	20	274861	32755	110281663
Device malfunction	33.24	20.07	11	274870	25547	110288871
Lung infiltration	33.10	20.07	10	274871	24618	110289800
Encephalitis	32.99	20.07	4	274877	18835	110295583
Glycosylated haemoglobin increased	32.83	20.07	9	274872	23610	110290808
Lacrimation increased	32.79	20.07	18	274863	30932	110283486
Musculoskeletal disorder	32.72	20.07	8	274873	22656	110291762
Renal injury	32.70	20.07	4	274877	18709	110295709
Affect lability	32.53	20.07	4	274877	18633	110295785
Conjunctivitis	32.53	20.07	22	274859	33770	110280648
Iron deficiency anaemia	32.51	20.07	19	274862	31540	110282878
Joint destruction	32.44	20.07	79	274802	10864	110303554
Staphylococcal sepsis	32.37	20.07	3	274878	17451	110296967
Right ventricular failure	32.33	20.07	12	274869	25942	110288476
Cardiomegaly	32.26	20.07	16	274865	29114	110285304
Petechiae	32.20	20.07	9	274872	23308	110291110
Full blood count decreased	32.12	20.07	20	274861	32079	110282339
Eye irritation	31.90	20.07	22	274859	33430	110280988
Enterococcal infection	31.83	20.07	6	274875	20360	110294058
Blood triglycerides increased	31.65	20.07	10	274871	23916	110290502
Tooth disorder	31.50	20.07	17	274864	29492	110284926
Lymphoma	31.40	20.07	6	274875	20165	110294253
Oral candidiasis	31.38	20.07	39	274842	44721	110269697
Transfusion	31.36	20.07	12	274869	25460	110288958
Nocturia	31.30	20.07	3	274878	16987	110297431
Pain of skin	31.09	20.07	6	274875	20023	110294395
Spinal fracture	30.77	20.07	9	274872	22624	110291794
Poisoning	30.73	20.07	17	274864	29088	110285330
Throat tightness	30.66	20.07	23	274858	33466	110280952
Injection site rash	30.60	20.07	10	274871	23409	110291009
Device difficult to use	30.57	20.07	5	274876	18800	110295618
Facial paralysis	30.50	20.07	11	274870	24203	110290215
Polyuria	30.49	20.07	4	274877	17734	110296684
Electrocardiogram abnormal	30.36	20.07	5	274876	18704	110295714
Blood pressure abnormal	30.33	20.07	9	274872	22415	110292003
Poor quality sleep	30.23	20.07	16	274865	28061	110286357
Colon cancer	30.04	20.07	3	274878	16440	110297978
Blood glucose decreased	30.03	20.07	18	274863	29470	110284948
Asthenia	30.01	20.07	1403	273478	687596	109626822
Arteriosclerosis	29.94	20.07	12	274869	24755	110289663
Hernia	29.94	20.07	6	274875	19494	110294924
Lower gastrointestinal haemorrhage	29.86	20.07	5	274876	18481	110295937
Gangrene	29.80	20.07	3	274878	16338	110298080
Cholangitis	29.79	20.07	3	274878	16332	110298086
Injection site warmth	29.74	20.07	4	274877	17401	110297017
Eye injury	29.71	20.07	62	274819	7693	110306725
Immune reconstitution inflammatory syndrome	29.54	20.07	3	274878	16223	110298195
Respiratory tract infection	29.46	20.07	86	274795	71531	110242887
Escherichia urinary tract infection	29.39	20.07	3	274878	16159	110298259
Hypertriglyceridaemia	29.37	20.07	3	274878	16151	110298267
Hiatus hernia	29.33	20.07	16	274865	27590	110286828
Ventricular extrasystoles	29.00	20.07	10	274871	22631	110291787
Ear pain	28.96	20.07	229	274652	52997	110261421
Atrial flutter	28.94	20.07	12	274869	24250	110290168
Product storage error	28.88	20.07	9	274872	21719	110292699
Stress cardiomyopathy	28.57	20.07	3	274878	15803	110298615
Respiratory disorder	28.47	20.07	287	274594	71095	110243323
Hypotonia	28.43	20.07	3	274878	15742	110298676
Needle issue	28.43	20.07	5	274876	17835	110296583
Depression	28.32	20.07	1009	273872	316326	109998092
Diarrhoea haemorrhagic	28.19	20.07	3	274878	15636	110298782
Tricuspid valve incompetence	28.16	20.07	12	274869	23861	110290557
Neurological symptom	28.12	20.07	3	274878	15605	110298813
Erectile dysfunction	27.89	20.07	6	274875	18550	110295868
Spinal pain	27.80	20.07	6	274875	18509	110295909
Iron deficiency	27.72	20.07	6	274875	18470	110295948
Supraventricular tachycardia	27.67	20.07	13	274868	24409	110290009
Sleep apnoea syndrome	27.57	20.07	36	274845	40411	110274007
Spinal compression fracture	27.53	20.07	6	274875	18386	110296032
Sensory disturbance	27.53	20.07	5	274876	17424	110296994
Vaginal haemorrhage	27.42	20.07	14	274867	25060	110289358
Skin burning sensation	27.34	20.07	10	274871	21815	110292603
Tenosynovitis	27.22	20.07	4	274877	16279	110298139
Toxic encephalopathy	27.22	20.07	3	274878	15211	110299207
Sputum discoloured	27.16	20.07	18	274863	27927	110286491
Dermatitis allergic	27.14	20.07	10	274871	21714	110292704
Fear	26.82	20.07	12	274869	23181	110291237
Paranoia	26.79	20.07	11	274870	22363	110292055
Pneumonia bacterial	26.78	20.07	16	274865	26245	110288173
Intervertebral disc protrusion	26.70	20.07	18	274863	27680	110286738
Device leakage	26.69	20.07	4	274877	16044	110298374
Bone density decreased	26.68	20.07	4	274877	16038	110298380
Respiratory symptom	26.60	20.07	3	274878	14942	110299476
Hypernatraemia	26.33	20.07	6	274875	17827	110296591
Eye swelling	26.24	20.07	26	274855	33022	110281396
Haemorrhoids	26.16	20.07	30	274851	35642	110278776
Pulmonary toxicity	26.14	20.07	6	274875	17740	110296678
Post procedural complication	26.14	20.07	17	274864	26641	110287777
Herpes simplex	26.06	20.07	4	274877	15760	110298658
Postoperative wound infection	26.03	20.07	4	274877	15749	110298669
Gingival pain	26.00	20.07	4	274877	15732	110298686
Spinal fusion surgery	25.98	20.07	65	274816	9091	110305327
Product dose omission in error	25.91	20.07	13	274868	23499	110290919
Blood urine present	25.83	20.07	14	274867	24231	110290187
Retching	25.82	20.07	12	274869	22670	110291748
Multiple sclerosis	25.73	20.07	16	274865	25682	110288736
Product use in unapproved indication	25.71	20.07	1359	273522	446018	109868400
Drug dose omission by device	25.62	20.07	3	274878	14513	110299905
Fatigue	25.49	20.07	3421	271460	1212537	109101881
Glaucoma	25.49	20.07	12	274869	22505	110291913
Complication associated with device	25.48	20.07	9	274872	20064	110294354
Skin infection	25.48	20.07	12	274869	22497	110291921
Flank pain	25.17	20.07	13	274868	23117	110291301
Product dispensing error	25.15	20.07	5	274876	16340	110298078
Arterial occlusive disease	25.04	20.07	4	274877	15304	110299114
Eye disorder	25.02	20.07	21	274860	28885	110285533
Fistula	25.02	20.07	4	274877	15295	110299123
Hydronephrosis	25.00	20.07	10	274871	20655	110293763
Squamous cell carcinoma of skin	24.98	20.07	6	274875	17197	110297221
Asphyxia	24.94	20.07	3	274878	14212	110300206
Procedural pain	24.92	20.07	31	274850	35534	110278884
Skin fissures	24.81	20.07	15	274866	24443	110289975
Odynophagia	24.68	20.07	3	274878	14098	110300320
Pharyngitis	24.62	20.07	16	274865	25082	110289336
Ageusia	24.61	20.07	9	274872	19636	110294782
Mood swings	24.56	20.07	13	274868	22799	110291619
Impaired quality of life	24.55	20.07	23	274858	29994	110284424
Acute pulmonary oedema	24.54	20.07	6	274875	16990	110297428
Bone disorder	24.45	20.07	11	274870	21181	110293237
Duodenal ulcer	24.35	20.07	9	274872	19505	110294913
Malignant melanoma	24.31	20.07	6	274875	16885	110297533
Increased appetite	24.31	20.07	4	274877	14973	110299445
Cardiotoxicity	24.29	20.07	6	274875	16875	110297543
Immunosuppression	24.25	20.07	7	274874	17752	110296666
Muscular weakness	24.16	20.07	798	274083	247670	110066748
Peripheral coldness	24.08	20.07	8	274873	18532	110295886
Pulseless electrical activity	24.03	20.07	6	274875	16751	110297667
Red cell distribution width increased	23.93	20.07	7	274874	17595	110296823
Autoimmune hepatitis	23.92	20.07	4	274877	14800	110299618
Staphylococcal bacteraemia	23.88	20.07	6	274875	16682	110297736
Acute generalised exanthematous pustulosis	23.84	20.07	12	274869	21652	110292766
Pulmonary haemorrhage	23.39	20.07	6	274875	16450	110297968
Angina unstable	23.34	20.07	6	274875	16426	110297992
Hyperlipidaemia	23.33	20.07	33	274848	35815	110278603
Ankle fracture	23.32	20.07	10	274871	19809	110294609
Brain injury	23.26	20.07	3	274878	13473	110300945
Nephropathy	23.24	20.07	3	274878	13464	110300954
Blood pressure systolic decreased	23.18	20.07	3	274878	13438	110300980
Aspiration	23.14	20.07	25	274856	30508	110283910
Injection site urticaria	23.12	20.07	7	274874	17208	110297210
Emotional distress	23.04	20.07	48	274833	44799	110269619
Eyelid ptosis	22.92	20.07	3	274878	13324	110301094
Rhinitis	22.62	20.07	14	274867	22531	110291887
Parosmia	22.59	20.07	3	274878	13177	110301241
Forced expiratory volume decreased	22.58	20.07	3	274878	13173	110301245
Respiratory tract congestion	22.58	20.07	26	274855	30831	110283587
Drug effective for unapproved indication	22.52	20.07	4	274877	14163	110300255
Gastric disorder	22.42	20.07	30	274851	33327	110281091
Vitamin D deficiency	22.41	20.07	9	274872	18543	110295875
Aortic stenosis	22.32	20.07	3	274878	13056	110301362
Eructation	22.27	20.07	4	274877	14053	110300365
Blood magnesium decreased	22.12	20.07	11	274870	19985	110294433
Arteriosclerosis coronary artery	22.05	20.07	18	274863	25100	110289318
Blood lactic acid increased	22.05	20.07	6	274875	15815	110298603
Osteopenia	22.00	20.07	14	274867	22195	110292223
Nervousness	21.98	20.07	36	274845	36815	110277603
Cholecystitis acute	21.96	20.07	6	274875	15776	110298642
Oral pain	21.95	20.07	37	274844	37407	110277011
Mood altered	21.83	20.07	13	274868	21362	110293056
Rebound effect	21.82	20.07	5	274876	14801	110299617
Decubitus ulcer	21.78	20.07	9	274872	18227	110296191
Caesarean section	21.75	20.07	4	274877	13813	110300605
Haemorrhagic stroke	21.68	20.07	4	274877	13785	110300633
Haemolysis	21.66	20.07	6	274875	15633	110298785
Paralysis	21.58	20.07	6	274875	15594	110298824
Central nervous system lesion	21.48	20.07	6	274875	15547	110298871
Heavy menstrual bleeding	21.36	20.07	7	274874	16358	110298060
Hypovolaemic shock	21.35	20.07	5	274876	14578	110299840
Hepatitis C	21.22	20.07	3	274878	12570	110301848
Paraesthesia oral	20.93	20.07	32	274849	33639	110280779
Pleuritic pain	20.90	20.07	7	274874	16133	110298285
Bedridden	20.89	20.07	4	274877	13421	110300997
Skin cancer	20.88	20.07	9	274872	17775	110296643
Diastolic dysfunction	20.84	20.07	3	274878	12401	110302017
Suspected suicide	20.74	20.07	6	274875	15193	110299225
Tongue disorder	20.74	20.07	5	274876	14293	110300125
Pulmonary congestion	20.66	20.07	28	274853	30938	110283480
Blood thyroid stimulating hormone increased	20.61	20.07	3	274878	12298	110302120
Choking	20.56	20.07	6	274875	15104	110299314
Musculoskeletal discomfort	20.50	20.07	17	274864	23521	110290897
Left ventricular hypertrophy	20.49	20.07	4	274877	13240	110301178
Quality of life decreased	20.46	20.07	5	274876	14164	110300254
Gastric haemorrhage	20.44	20.07	7	274874	15908	110298510
Vitamin D decreased	20.42	20.07	3	274878	12212	110302206
Anal incontinence	20.22	20.07	15	274866	21949	110292469
Anger	20.22	20.07	11	274870	18996	110295422
Sleep disorder due to general medical condition, hypersomnia type	20.16	20.07	25	274856	1994	110312424
Musculoskeletal deformity	20.15	20.07	22	274859	1531	110312887
Gastrointestinal infection	20.11	20.07	5	274876	14000	110300418
Exercise tolerance decreased	20.09	20.07	3	274878	12064	110302354

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R01BA02	RESPIRATORY SYSTEM NASAL PREPARATIONS NASAL DECONGESTANTS FOR SYSTEMIC USE Sympathomimetics
ATC	R01BA52	RESPIRATORY SYSTEM NASAL PREPARATIONS NASAL DECONGESTANTS FOR SYSTEMIC USE Sympathomimetics
FDA MoA	N0000000209	Adrenergic alpha-Agonists
FDA EPC	N0000175552	alpha-Adrenergic Agonist
CHEBI has role	CHEBI:76924	plant metabolite
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D014662	Vasoconstrictor Agents
MeSH PA	D014663	Nasal Decongestants
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D019141	Respiratory System Agents
CHEBI has role	CHEBI:35470	central nervous system drug
CHEBI has role	CHEBI:35523	bronchodilator agent
CHEBI has role	CHEBI:35524	sympathomimetic agent
CHEBI has role	CHEBI:35703	xenobiotic
CHEBI has role	CHEBI:49167	anti-asthmatic drug
CHEBI has role	CHEBI:50514	vasoconstrictor agent
CHEBI has role	CHEBI:50857	anti-allergic agent
CHEBI has role	CHEBI:51177	antitussive
CHEBI has role	CHEBI:67079	anti-inflammatory agent
CHEBI has role	CHEBI:77715	nasal decongestant

Related Drugs by ATC class:

R01BA Sympathomimetics 2 drugs

phenylephrine phenylpropanolamine

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Sinus headache	indication	4969004
Vasomotor rhinitis	indication	8229003	DOID:4730
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Rhinitis	indication	70076002	DOID:4483
Common cold	indication	82272006	DOID:10459
Headache disorder	indication	230461009
Influenza-like symptoms	indication	315642008
Seasonal allergic rhinitis	indication	367498001
Allergic conjunctivitis	indication	473460002	DOID:11204
Eustachian Tube Congestion	indication
Brain damage	contraindication	2470005
Ocular hypertension	contraindication	4210003	DOID:9282
Tachyarrhythmia	contraindication	6285003
Suicidal thoughts	contraindication	6471006
Dependent drug abuse	contraindication	6525002
Urinary tract obstruction	contraindication	7163005	DOID:5200
Alcoholism	contraindication	7200002
Alcohol withdrawal delirium	contraindication	8635005
Peptic ulcer	contraindication	13200003	DOID:750
Chronic obstructive lung disease	contraindication	13645005	DOID:3083
Asthenia	contraindication	13791008
Hyperkalemia	contraindication	14140009
Severe chronic ulcerative colitis	contraindication	14311001
Constipation	contraindication	14760008	DOID:2089
Disorder of autonomic nervous system	contraindication	15241006
Chronic disease of respiratory system	contraindication	17097001
Mood swings	contraindication	18963009
Pulmonary edema	contraindication	19242006	DOID:11396
Myocardial infarction	contraindication	22298006	DOID:5844
Glaucoma	contraindication	23986001	DOID:1686
Inflammatory bowel disease	contraindication	24526004	DOID:0050589
Ventricular tachycardia	contraindication	25569003
Alcohol intoxication	contraindication	25702006
Shock	contraindication	27942005
Toxic megacolon	contraindication	28536002	DOID:1770
Atony of colon	contraindication	29479008
Hypercapnia	contraindication	29596007
Dehydration	contraindication	34095006
Hyperthyroidism	contraindication	34486009	DOID:7998
Acute hepatitis	contraindication	37871000
Hypertensive disorder	contraindication	38341003	DOID:10763
Hypovolemic shock	contraindication	39419009
Disorder of gallbladder	contraindication	39621005	DOID:0060262
Gastrointestinal ulcer	contraindication	40845000
Hypothyroidism	contraindication	40930008	DOID:1459
Complete trisomy 21 syndrome	contraindication	41040004	DOID:14250
Third trimester pregnancy	contraindication	41587001
Body fluid retention	contraindication	43498006
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Achalasia of esophagus	contraindication	45564002	DOID:9164
Chronic heart failure	contraindication	48447003
Bradycardia	contraindication	48867003
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Acidosis	contraindication	51387008
Gastrointestinal perforation	contraindication	51875005
Coronary arteriosclerosis	contraindication	53741008	DOID:3393
Paralytic ileus	contraindication	55525008	DOID:8442
Peptic reflux disease	contraindication	57643001
Multiple organ failure	contraindication	57653000
Acute nephropathy	contraindication	58574008
Metabolic acidosis	contraindication	59455009
Hepatic failure	contraindication	59927004
Ulcerative colitis	contraindication	64766004	DOID:8577
Blood coagulation disorder	contraindication	64779008	DOID:1247
Arterial thrombosis	contraindication	65198009
Drug AND/OR toxin-induced diarrhea	contraindication	65979008
Substance abuse	contraindication	66214007
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Poisoning by acetaminophen	contraindication	70273001
Arteriosclerotic vascular disease	contraindication	72092001
Diabetes mellitus	contraindication	73211009	DOID:9351
Gastrointestinal hemorrhage	contraindication	74474003
Urethral stricture	contraindication	76618002
Spastic paralysis	contraindication	78403003
Disturbance of salivary secretion	contraindication	78948009
Decreased respiratory function	contraindication	80954004
Injury of head	contraindication	82271004
Chronic idiopathic constipation	contraindication	82934008
Cor pulmonale	contraindication	83291003	DOID:8515
Hiatal hernia	contraindication	84089009	DOID:12642
Epilepsy	contraindication	84757009	DOID:1826
Pulmonary emphysema	contraindication	87433001
Kidney disease	contraindication	90708001	DOID:557
Myasthenia gravis	contraindication	91637004	DOID:437
Acute abdominal pain	contraindication	116290004
Procedure on urinary system	contraindication	118677009
Gastrointestinal obstruction	contraindication	126765001
Neoplasm of brain	contraindication	126952004	DOID:1319
Seizure disorder	contraindication	128613002
Autonomic dysreflexia	contraindication	129618003
Bleeding	contraindication	131148009
Liver function tests abnormal	contraindication	166603001
Cystic fibrosis	contraindication	190905008	DOID:1485
Drug-induced psychosis	contraindication	191483003	DOID:1742
Angina pectoris	contraindication	194828000
Partial atrioventricular block	contraindication	195039008
Acute pancreatitis	contraindication	197456007	DOID:2913
Impaired renal function disorder	contraindication	197663003
Cerebrovascular accident	contraindication	230690007
Coronary artery bypass graft	contraindication	232717009
Myocardial dysfunction	contraindication	233928007
Gastroesophageal reflux disease	contraindication	235595009	DOID:8534
Disease of liver	contraindication	235856003	DOID:409
Hyporeninemic hypoaldosteronism	contraindication	236464008
Bladder outflow obstruction	contraindication	236645006
Morbid obesity	contraindication	238136002	DOID:11981
Sepsis syndrome	contraindication	238150007
Rhabdomyolysis	contraindication	240131006
Pyloric obstruction	contraindication	244815007
Esophageal dysmotility	contraindication	266434009	DOID:9192
Benign prostatic hyperplasia	contraindication	266569009
Edema	contraindication	267038008
Retention of urine	contraindication	267064002
Anemia	contraindication	271737000	DOID:2355
Continuous fever	contraindication	271751000
Drowsy	contraindication	271782001
Exacerbation of asthma	contraindication	281239006
Pregnancy, function	contraindication	289908002
Lesion of brain	contraindication	301766008
Thromboembolic disorder	contraindication	371039008
Coma	contraindication	371632003
Primary adrenocortical insufficiency	contraindication	373662000
Smoking cessation assistance	contraindication	384742004
Operation on gastrointestinal tract	contraindication	386621005
Hypoxia	contraindication	389086002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Cardiovascular event risk	contraindication	395112001
Pseudomembranous enterocolitis	contraindication	397683000
Gastric ulcer	contraindication	397825006	DOID:10808
Breastfeeding (mother)	contraindication	413712001
Chronic lung disease	contraindication	413839001
Disorder of coronary artery	contraindication	414024009
Traumatic injury	contraindication	417746004
Central nervous system depression	contraindication	418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant	contraindication	422681000
Fever greater than 100.4 Fahrenheit	contraindication	426000000
Dysfunction of sphincter of Oddi	contraindication	430887001
Hypertensive urgency	contraindication	443482000
Smokes tobacco daily	contraindication	449868002
Acute exacerbation of asthma	contraindication	708038006
Acute Thromboembolic Stroke	contraindication
Theophylline Toxicity	contraindication
Severe Hypoxemia	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.22	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Bioact source	MoA source
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN	RELEASING AGENT	CHEMBL	CHEMBL
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN		WOMBAT-PK
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		WOMBAT-PK
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		WOMBAT-PK

External reference:

ID	Source
4018571	VUID
N0000178581	NUI
D00485	KEGG_DRUG
345-78-8	SECONDARY_CAS_RN
7460-12-0	SECONDARY_CAS_RN
4018043	VANDF
4018571	VANDF
4018802	VANDF
C0033798	UMLSCUI
CHEBI:51209	CHEBI
CHEMBL1590	ChEMBL_ID
DB00852	DRUGBANK_ID
CHEMBL1200724	ChEMBL_ID
CHEMBL3989855	ChEMBL_ID
D054199	MESH_DESCRIPTOR_UI
7028	PUBCHEM_CID
1061	INN_ID
7286	IUPHAR_LIGAND_ID
7CUC9DDI9F	UNII
407885	RXNORM
2354	MMSL
5382	MMSL
5383	MMSL
5384	MMSL
d00769	MMSL
001831	NDDF
001832	NDDF
001833	NDDF
005972	NDDF
10595003	SNOMEDCT_US
12177002	SNOMEDCT_US
372900003	SNOMEDCT_US
91435002	SNOMEDCT_US
CHEMBL1201483	ChEMBL_ID
7CUC9DDI9F	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Dimetapp	HUMAN OTC DRUG LABEL	2	0031-2231	ELIXIR	15 mg	ORAL	Export only	15 sections
Dimetapp Paediatric	HUMAN OTC DRUG LABEL	2	0031-2251	ELIXIR	15 mg	ORAL	Export only	1 sections
Robitussin CF	HUMAN OTC DRUG LABEL	3	0031-8678	LIQUID	30 mg	ORAL	Export only	15 sections
Theraflu-D Flu Relief Max Strength plus Nasal Decongestant Nighttime	HUMAN OTC DRUG LABEL	4	0067-0114	SYRUP	60 mg	ORAL	OTC Monograph Drug	17 sections
Theraflu-D Flu Relief Max Strength plus Nasal Decongestant	HUMAN OTC DRUG LABEL	3	0067-0115	SYRUP	60 mg	ORAL	OTC Monograph Drug	17 sections
Good Sense Suphedrine12 Hour	HUMAN OTC DRUG LABEL	1	0113-0054	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	14 sections
Good Sense Suphedrine12 Hour	HUMAN OTC DRUG LABEL	1	0113-0054	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	14 sections
good sense all day allergy d	HUMAN OTC DRUG LABEL	2	0113-0147	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	16 sections
Zephrex D	HUMAN OTC DRUG LABEL	1	0113-0401	CAPSULE, GELATIN COATED	30 mg	ORAL	OTC Monograph Drug	15 sections
Good Sense Nasal Decongestant	HUMAN OTC DRUG LABEL	1	0113-0432	TABLET, FILM COATED	30 mg	ORAL	OTC Monograph Drug	15 sections
Allergy and Congestion Relief	HUMAN OTC DRUG LABEL	2	0113-2007	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	14 sections
sinus 12 hour	HUMAN OTC DRUG LABEL	1	0113-2017	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	15 sections
All Day Allergy D	HUMAN OTC DRUG LABEL	2	0113-2147	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	16 sections
perrigo allergy d	HUMAN OTC DRUG LABEL	2	0113-7777	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	15 sections
mucus D	HUMAN OTC DRUG LABEL	2	0113-8307	TABLET, MULTILAYER, EXTENDED RELEASE	60 mg	ORAL	ANDA	14 sections
Mucus D	HUMAN OTC DRUG LABEL	2	0113-8911	TABLET, MULTILAYER, EXTENDED RELEASE	120 mg	ORAL	ANDA	15 sections
allergy d	HUMAN OTC DRUG LABEL	2	0113-9004	TABLET, EXTENDED RELEASE	240 mg	ORAL	ANDA	15 sections
Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide	HUMAN PRESCRIPTION DRUG LABEL	3	0121-0933	SOLUTION	30 mg	ORAL	ANDA	21 sections
Aleve-D Sinus and Headache	HUMAN OTC DRUG LABEL	2	0280-6045	TABLET	120 mg	ORAL	ANDA	17 sections
Aleve-D Sinus and Cold	HUMAN OTC DRUG LABEL	2	0280-6090	TABLET	120 mg	ORAL	ANDA	17 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride	HUMAN OTC DRUG LABEL	2	0363-0044	TABLET, EXTENDED RELEASE	120 mg	ORAL	ANDA	14 sections
Fexofenadine HCl and Pseudoephedrine HCl	HUMAN OTC DRUG LABEL	2	0363-0049	TABLET, EXTENDED RELEASE	240 mg	ORAL	ANDA	14 sections
Guaifenesin and Pseudoephedrine Hydrochloride	HUMAN OTC DRUG LABEL	2	0363-0077	TABLET, EXTENDED RELEASE	60 mg	ORAL	NDA	16 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride	Human OTC Drug Label	2	0363-0094	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	11 sections
Guaifenesin and Pseudoephedrine HCl	Human OTC Drug Label	2	0363-0134	TABLET, EXTENDED RELEASE	120 mg	ORAL	ANDA	14 sections
Pseudoephedrine Hydrochloride	HUMAN OTC DRUG LABEL	1	0363-0204	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	16 sections
Cold and Allergy D	HUMAN OTC DRUG LABEL	2	0363-0287	TABLET, FILM COATED	60 mg	ORAL	OTC Monograph Drug	16 sections
Ibuprofen and Pseudoephedrine Hydrochloride	HUMAN OTC DRUG LABEL	2	0363-0423	TABLET, COATED	30 mg	ORAL	ANDA	17 sections
All Day Sinus and Cold D	HUMAN OTC DRUG LABEL	2	0363-0650	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	16 sections
Loratadine and Pseudoephedrine	HUMAN OTC DRUG LABEL	2	0363-0725	TABLET, FILM COATED, EXTENDED RELEASE	240 mg	ORAL	ANDA	16 sections

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pseudoephedrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: