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dopamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
dopaminergic agents dopamine derivatives used as cardiac stimulant/antihypertensives/diuretics	947	51-61-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: dopamine oxytyramine dopamin dophamine hydroxytyramin dopamine hydrochloride dopamine HCl	One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action. Molecular weight: 153.18 Formula: C8H11NO2 CLOGP: 0.17 LIPINSKI: 0 HAC: 3 HDO: 3 TPSA: 66.48 ALOGS: -1.31 ROTB: 2 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dopamine
oxytyramine
dopamin
dophamine
hydroxytyramin
dopamine hydrochloride
dopamine HCl

One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.

Molecular weight: 153.18
Formula: C8H11NO2
CLOGP: 0.17
LIPINSKI: 0
HAC: 3
HDO: 3
TPSA: 66.48
ALOGS: -1.31
ROTB: 2

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.50	g	P

ADMET properties:

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Property	Value	Reference
CL (Clearance)	65.90 mL/min/kg	Lombardo F, Berellini G, Obach RS
MRTD (Maximum Recommended Therapeutic Daily Dose)	470 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
S (Water solubility)	18.96 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Hosey CM, Chan R, Benet LZ
fu (Fraction unbound in plasma)	0.87 %	Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)	0.74 L/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	0.42 hours	Lombardo F, Berellini G, Obach RS

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Approvals:

Date	Agency	Company	Orphan
Feb. 25, 1974	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple organ dysfunction syndrome	101.53	25.37	56	3979	56696	63428291
Renal ischaemia	73.89	25.37	15	4020	618	63484369
Cardiac arrest	69.68	25.37	53	3982	92492	63392495
Drug ineffective	65.51	25.37	178	3857	1044587	62440400
PCO2 increased	63.85	25.37	15	4020	1224	63483763
Hypotension	61.76	25.37	81	3954	272523	63212464
Blood bicarbonate decreased	59.90	25.37	17	4018	2924	63482063
Left ventricle outflow tract obstruction	59.12	25.37	11	4024	285	63484702
PO2 increased	57.92	25.37	13	4022	866	63484121
Diabetes insipidus	57.21	25.37	16	4019	2609	63482378

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	68.50	21.90	156	3834	456595	34496346
Multiple organ dysfunction syndrome	58.92	21.90	57	3933	76509	34876432
Disseminated intravascular coagulation	49.76	21.90	31	3959	21785	34931156
Hypotension	43.76	21.90	85	3905	221564	34731377
Shock	39.72	21.90	28	3962	24151	34928790
Torsade de pointes	38.40	21.90	18	3972	7191	34945750
Blood urea increased	38.30	21.90	30	3960	30334	34922607
Ventricular fibrillation	34.08	21.90	25	3965	22929	34930012
Cardiac arrest	32.50	21.90	47	3943	96112	34856829
Acute kidney injury	31.66	21.90	91	3899	304897	34648044

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple organ dysfunction syndrome	114.96	21.18	92	7193	120154	79616949
Drug ineffective	106.54	21.18	274	7011	1080639	78656464
Hypotension	89.82	21.18	151	7134	440166	79296937
Cardiac arrest	88.45	21.18	93	7192	172003	79565100
Shock	78.16	21.18	49	7236	43499	79693604
Disseminated intravascular coagulation	76.32	21.18	45	7240	35797	79701306
Cardiogenic shock	67.37	21.18	44	7241	41870	79695233
Renal ischaemia	59.39	21.18	15	7270	1147	79735956
Blood urea increased	59.03	21.18	43	7242	48747	79688356
PCO2 increased	57.08	21.18	16	7269	1824	79735279

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	C01CA04	CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES Adrenergic and dopaminergic agents
CHEBI has role	CHEBI:35522	beta-adrenergic agonists
CHEBI has role	CHEBI:35524	sympathomimetic
CHEBI has role	CHEBI:38147	cardiotonic drugs
CHEBI has role	CHEBI:48560	dopaminergic agents
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
FDA CS	M0003647	Catecholamines
FDA EPC	N0000175570	Catecholamine

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID
Low cardiac output syndrome	indication	44088000
Low blood pressure	indication	45007003
Decompensated cardiac failure	indication	195111005
Sinus bradycardia	off-label use	49710005
Acute nephropathy	off-label use	58574008
Tachyarrhythmia	contraindication	6285003
Hypovolemia	contraindication	28560003
Ventricular arrhythmia	contraindication	44103008
Acidosis	contraindication	51387008
Pheochromocytoma	contraindication	302835009

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.96	acidic
pKa2	12.98	acidic
pKa3	10.61	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN	AGONIST	Ki	5	WOMBAT-PK	CHEMBL
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN		Kd	4.19	CHEMBL
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN	AGONIST	Ki	9	WOMBAT-PK
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN	AGONIST	Ki	9	WOMBAT-PK
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		IC50	8.18	WOMBAT-PK
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	5.08	PDSP
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN	AGONIST	Ki	9	WOMBAT-PK
D(1B) dopamine receptor	GPCR	P21918	DRD5_HUMAN	AGONIST	Ki	9	WOMBAT-PK
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	5.19	CHEMBL
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN	AGONIST	Ki	9	WOMBAT-PK

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External reference:

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ID	Source
LDP	PDB_CHEM_ID
001787	NDDF
004721	NDDF
16257000	SNOMEDCT_US
2417	INN_ID
3090	MMSL
3628	RXNORM
4018656	VANDF
4019733	VUID
4019733	VANDF

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
DOPAMINE HCI	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1220	INJECTION, SOLUTION, CONCENTRATE	40 mg	INTRAVENOUS	NDA	12 sections
DOPAMINE HCI	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1220	INJECTION, SOLUTION, CONCENTRATE	40 mg	INTRAVENOUS	NDA	12 sections
DOPAMINE HCI	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1291	INJECTION, SOLUTION, CONCENTRATE	40 mg	INTRAVENOUS	NDA	12 sections
DOPAMINE HCI	HUMAN PRESCRIPTION DRUG LABEL	1	51662-1291	INJECTION, SOLUTION, CONCENTRATE	40 mg	INTRAVENOUS	NDA	12 sections
Dopamine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9252	INJECTION	40 mg	INTRAVENOUS	ANDA	16 sections
Dopamine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9252	INJECTION	40 mg	INTRAVENOUS	ANDA	16 sections
Dopamine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9253	INJECTION	80 mg	INTRAVENOUS	ANDA	16 sections
Dopamine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9253	INJECTION	80 mg	INTRAVENOUS	ANDA	16 sections
Dopamine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9254	INJECTION	40 mg	INTRAVENOUS	ANDA	16 sections
Dopamine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9254	INJECTION	40 mg	INTRAVENOUS	ANDA	16 sections

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