tramazoline Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihistaminics or local vasoconstrictors, antazoline derivatives 3620 1082-57-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tramazoline hydrochloride
  • tramazoline HCl
  • tramazoline
  • rhinol
  • Molecular weight: 215.30
  • Formula: C13H17N3
  • CLOGP: 2.59
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 36.42
  • ALOGS: -2.72
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC R01AA09 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Sympathomimetics, plain
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013566 Sympathomimetics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Sneezing indication 76067001
Common cold indication 82272006 DOID:10459
Seasonal allergic rhinitis indication 367498001
Allergic conjunctivitis indication 473460002 DOID:11204
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Chronic idiopathic constipation contraindication 82934008
Gastrointestinal obstruction contraindication 126765001
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.92 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-2C adrenergic receptor GPCR Ki 6.56 PDSP
Alpha-2B adrenergic receptor GPCR Ki 6.86 PDSP
Alpha-2A adrenergic receptor GPCR Ki 7.50 PDSP
Adrenergic receptor alpha-2 GPCR Ki 8.38 CHEMBL
Adrenergic receptor alpha-1 GPCR IC50 5.96 CHEMBL

External reference:

IDSource
C0076890 UMLSCUI
D01347 KEGG_DRUG
4DG710Q678 UNII
3715-90-0 SECONDARY_CAS_RN
421308003 SNOMEDCT_US
420558000 SNOMEDCT_US
38453 RXNORM
004058 NDDF
5524 PUBCHEM_CID
CHEBI:134893 CHEBI
CHEMBL32573 ChEMBL_ID
1831 INN_ID
DB13064 DRUGBANK_ID
CHEMBL2107640 ChEMBL_ID
C005370 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None