nicotinamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
nicotinic acid or nicotinoyl alcohol derivatives 1906 98-92-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • niacinamide
  • nicotinamide
  • 3-pyridinecarboxamide
An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
  • Molecular weight: 122.13
  • Formula: C6H6N2O
  • CLOGP: -0.21
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 55.98
  • ALOGS: -0.39
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1000 mg/mL Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1778.79 10.42 4410 527521 179316 62777775
Systemic lupus erythematosus 1672.21 10.42 4671 527260 204247 62752844
Glossodynia 1479.07 10.42 4048 527883 174828 62782263
Hand deformity 1206.41 10.42 3495 528436 155962 62801129
Arthropathy 1126.17 10.42 4414 527517 230378 62726713
Abdominal discomfort 1052.41 10.42 5387 526544 315498 62641593
Alopecia 1027.68 10.42 5551 526380 331985 62625106
Wound 999.80 10.42 3325 528606 159938 62797153
Completed suicide 957.39 10.42 68 531863 145605 62811486
Rheumatoid arthritis 896.54 10.42 4353 527578 249466 62707625
Maternal exposure during pregnancy 881.61 10.42 3916 528015 216146 62740945
Synovitis 796.41 10.42 3389 528542 183529 62773562
Toxicity to various agents 762.97 10.42 574 531357 246676 62710415
Anti-cyclic citrullinated peptide antibody positive 756.21 10.42 2417 529514 113795 62843296
Pericarditis 750.05 10.42 2617 529314 128962 62828129
Swelling 745.36 10.42 4390 527541 270988 62686103
Discomfort 743.60 10.42 3074 528857 164300 62792791
Contraindicated product administered 715.20 10.42 3658 528273 213990 62743101
Infusion related reaction 712.03 10.42 3987 527944 241534 62715557
Joint swelling 672.81 10.42 4873 527058 322793 62634298
Pain 606.02 10.42 9122 522809 731506 62225585
Death 537.12 10.42 1494 530437 372887 62584204
Duodenal ulcer perforation 476.42 10.42 1711 530220 85498 62871593
Rheumatoid factor positive 467.06 10.42 1663 530268 82743 62874348
Helicobacter infection 463.02 10.42 1768 530163 91017 62866074
Product use issue 444.65 10.42 3267 528664 217253 62739838
Drug interaction 426.82 10.42 793 531138 228338 62728753
Intentional overdose 418.99 10.42 61 531870 74091 62883000
Hepatic enzyme increased 411.56 10.42 3004 528927 199324 62757767
Drug abuse 384.43 10.42 71 531860 72447 62884644
Arthralgia 382.58 10.42 6797 525134 562913 62394178
Psoriatic arthropathy 349.50 10.42 1607 530324 89913 62867178
Musculoskeletal stiffness 340.47 10.42 2679 529252 181939 62775152
Therapeutic product effect decreased 326.90 10.42 2749 529182 190438 62766653
Febrile neutropenia 311.79 10.42 319 531612 118130 62838961
Drug intolerance 310.54 10.42 3949 527982 304712 62652379
Suicide attempt 278.63 10.42 82 531849 60836 62896255
Exposure during pregnancy 277.86 10.42 2241 529690 153306 62803785
Treatment failure 270.10 10.42 2701 529230 196342 62760749
Depressed level of consciousness 252.11 10.42 102 531829 61976 62895115
Acute kidney injury 250.68 10.42 1244 530687 262171 62694920
Hip arthroplasty 247.58 10.42 920 531011 46726 62910365
Cardiac arrest 243.80 10.42 249 531682 92296 62864795
Knee arthroplasty 241.39 10.42 997 530934 53209 62903882
Overdose 241.08 10.42 369 531562 114709 62842382
Hypersensitivity 233.73 10.42 3595 528336 289090 62668001
Malignant neoplasm progression 219.69 10.42 218 531713 81903 62875188
Rheumatic fever 209.61 10.42 815 531116 42296 62914795
Impaired healing 205.06 10.42 1517 530414 101025 62856066
Disease progression 204.37 10.42 453 531478 122305 62834786
Nasopharyngitis 196.03 10.42 3105 528826 251152 62705939
Neutropenia 187.50 10.42 791 531140 174214 62782877
Swollen joint count increased 183.00 10.42 691 531240 35363 62921728
Sedation 174.28 10.42 54 531877 38755 62918336
Blister 170.37 10.42 1750 530181 128064 62829027
Folliculitis 170.02 10.42 1090 530841 69227 62887864
Electrocardiogram QT prolonged 169.86 10.42 149 531782 59381 62897710
Hyponatraemia 166.44 10.42 438 531493 111462 62845629
Red blood cell sedimentation rate abnormal 165.29 10.42 450 531481 19332 62937759
Muscle injury 164.87 10.42 1024 530907 64321 62892770
Bradycardia 163.97 10.42 224 531707 73003 62884088
Constipation 163.63 10.42 1157 530774 223786 62733305
Lactic acidosis 161.95 10.42 59 531872 38228 62918863
Fatigue 152.20 10.42 8983 522948 879045 62078046
Hypotension 149.27 10.42 1511 530420 271093 62685998
Sleep disorder due to general medical condition, insomnia type 145.61 10.42 840 531091 51377 62905714
Cardiac failure 145.05 10.42 333 531598 88809 62868282
Nausea 143.01 10.42 5785 526146 848686 62108405
Sickle cell anaemia with crisis 140.45 10.42 210 531721 5793 62951298
Rash 140.44 10.42 5888 526043 554983 62402108
Drug reaction with eosinophilia and systemic symptoms 136.72 10.42 56 531875 33780 62923311
Irritable bowel syndrome 135.62 10.42 1166 530765 81246 62875845
Agitation 135.60 10.42 181 531750 59576 62897515
Somnolence 132.89 10.42 913 531018 177772 62779319
Renal failure 132.73 10.42 521 531410 117131 62839960
Hyperhidrosis 132.48 10.42 461 531470 107375 62849716
Rhabdomyolysis 131.55 10.42 105 531826 43846 62913245
Diarrhoea 131.23 10.42 4790 527141 710576 62246515
Respiratory arrest 130.34 10.42 55 531876 32590 62924501
C-reactive protein abnormal 128.83 10.42 742 531189 45354 62911737
Drug hypersensitivity 128.07 10.42 1832 530099 308855 62648236
Lower respiratory tract infection 122.36 10.42 1668 530263 130639 62826452
Neoplasm progression 122.21 10.42 77 531854 36351 62920740
Asthenia 122.09 10.42 2372 529559 381232 62575859
Sopor 121.16 10.42 20 531911 22144 62934947
Tremor 120.81 10.42 633 531298 131606 62825485
Blood cholesterol increased 120.66 10.42 1262 530669 92770 62864321
Osteoarthritis 116.92 10.42 1268 530663 94075 62863016
Intentional self-injury 116.67 10.42 35 531896 25652 62931439
Anxiety 114.44 10.42 1217 530714 216324 62740767
Vomiting 113.13 10.42 3701 528230 555916 62401175
Dyspnoea 112.37 10.42 4468 527463 656845 62300246
Tachycardia 112.23 10.42 558 531373 117598 62839493
Cardio-respiratory arrest 109.27 10.42 210 531721 59749 62897342
Thrombocytopenia 107.65 10.42 782 531149 150375 62806716
Serotonin syndrome 107.22 10.42 53 531878 28629 62928462
Syncope 103.83 10.42 568 531363 116817 62840274
Liver injury 103.65 10.42 864 531067 59656 62897435
Arthritis 102.95 10.42 1451 530480 114470 62842621
Type 2 diabetes mellitus 102.13 10.42 898 531033 62970 62894121
Pregnancy 100.37 10.42 589 531342 36247 62920844
Condition aggravated 100.11 10.42 4221 527710 397996 62559095
Hypoglycaemia 99.63 10.42 222 531709 59843 62897248
Cognitive disorder 98.68 10.42 199 531732 55616 62901475
Psoriasis 96.44 10.42 1134 530797 85823 62871268
Fibromyalgia 94.68 10.42 1061 530870 79359 62877732
Metabolic acidosis 92.92 10.42 146 531785 44923 62912168
No adverse event 92.33 10.42 127 531804 41278 62915813
Hepatic failure 90.44 10.42 99 531832 35557 62921534
Renal impairment 89.31 10.42 408 531523 87947 62869144
Intentional product misuse 87.12 10.42 243 531688 60674 62896417
Coma 86.77 10.42 264 531667 64100 62892991
Anaemia 86.52 10.42 1837 530094 291593 62665498
Intentional product use issue 85.27 10.42 1526 530405 126366 62830725
Peripheral swelling 85.05 10.42 2870 529061 263072 62694019
Drug resistance 84.79 10.42 43 531888 22890 62934201
Drug ineffective 84.70 10.42 9988 521943 1034777 61922314
Live birth 84.06 10.42 431 531500 25199 62931892
Sedation complication 83.82 10.42 9 531922 13813 62943278
Drug dependence 81.78 10.42 52 531879 24431 62932660
Respiratory failure 81.47 10.42 509 531422 101349 62855742
Ill-defined disorder 81.08 10.42 1044 530887 80711 62876380
Abortion spontaneous 80.93 10.42 674 531257 46521 62910570
Hepatic function abnormal 80.75 10.42 116 531815 37026 62920065
Multiple organ dysfunction syndrome 80.70 10.42 227 531704 56525 62900566
Orthostatic hypotension 80.54 10.42 111 531820 36049 62921042
Hyperglycaemia 80.40 10.42 142 531789 41725 62915366
Multiple sclerosis relapse 79.73 10.42 180 531751 48298 62908793
Contusion 79.72 10.42 1730 530201 148314 62808777
Joint effusion 79.26 10.42 318 531613 16742 62940349
Asthma 78.74 10.42 686 531245 126875 62830216
Seizure 78.49 10.42 721 531210 131913 62825178
Altered state of consciousness 78.40 10.42 58 531873 25172 62931919
Neuropathy peripheral 77.60 10.42 595 531336 113072 62844019
Myalgia 76.90 10.42 820 531111 145709 62811382
Angioedema 76.54 10.42 181 531750 47784 62909307
Dizziness 75.80 10.42 2891 529040 427034 62530057
Drug withdrawal syndrome 74.08 10.42 71 531860 27123 62929968
Blood pressure diastolic abnormal 74.02 10.42 279 531652 14263 62942828
Blood pressure fluctuation 73.92 10.42 651 531280 45666 62911425
Hallucination 73.78 10.42 225 531706 54592 62902499
Blood pressure systolic abnormal 73.33 10.42 263 531668 13123 62943968
Creatinine renal clearance decreased 70.90 10.42 24 531907 16284 62940807
Drug ineffective for unapproved indication 70.55 10.42 110 531821 33953 62923138
Hypoxia 70.49 10.42 260 531671 59532 62897559
Sinusitis 69.92 10.42 2436 529495 224217 62732874
Hyperkalaemia 69.77 10.42 227 531704 53976 62903115
Encephalopathy 69.72 10.42 136 531795 38484 62918607
Product quality issue 69.46 10.42 121 531810 35744 62921347
Cytomegalovirus infection 69.30 10.42 45 531886 20907 62936184
Device expulsion 69.30 10.42 116 531815 34806 62922285
Blood glucose increased 68.82 10.42 415 531516 83341 62873750
Dehydration 68.60 10.42 1030 530901 172324 62784767
Hepatocellular injury 68.37 10.42 77 531854 27304 62929787
Foot deformity 68.06 10.42 433 531498 27420 62929671
Red blood cell sedimentation rate increased 68.04 10.42 614 531317 43368 62913723
Neutrophil count decreased 67.34 10.42 244 531687 56162 62900929
Disability assessment scale score increased 67.09 10.42 107 531824 3126 62953965
Metastases to bone 67.04 10.42 47 531884 20972 62936119
Anaphylactic reaction 66.93 10.42 305 531626 65795 62891296
Cholestasis 66.93 10.42 89 531842 29345 62927746
Palmar-plantar erythrodysaesthesia syndrome 66.38 10.42 57 531874 22958 62934133
Cardiac failure congestive 66.36 10.42 477 531454 91956 62865135
Balance disorder 65.90 10.42 425 531506 83997 62873094
Chest discomfort 65.83 10.42 596 531335 109373 62847718
Leukopenia 64.01 10.42 382 531549 76908 62880183
Vision blurred 63.77 10.42 479 531452 91445 62865646
Ejection fraction decreased 63.57 10.42 56 531875 22276 62934815
Basal cell carcinoma 62.84 10.42 426 531505 27565 62929526
COVID-19 60.12 10.42 631 531300 112472 62844619
Poisoning 59.85 10.42 20 531911 13680 62943411
Osteonecrosis of jaw 59.74 10.42 128 531803 34995 62922096
Product use in unapproved indication 59.71 10.42 1098 530833 177982 62779109
Shock 59.66 10.42 65 531866 23398 62933693
Myocardial infarction 59.53 10.42 542 531389 99351 62857740
Hypokalaemia 59.38 10.42 569 531362 103235 62853856
Grip strength decreased 59.19 10.42 354 531577 21933 62935158
Diabetic ketoacidosis 58.87 10.42 51 531880 20454 62936637
Injection site erythema 58.84 10.42 1002 530929 82172 62874919
Feeling abnormal 58.60 10.42 882 531049 147510 62809581
Anaphylactic shock 58.42 10.42 67 531864 23566 62933525
Pulmonary fibrosis 58.18 10.42 549 531382 39260 62917831
Stomatitis 57.47 10.42 1546 530385 137179 62819912
Suicidal ideation 57.42 10.42 298 531633 62123 62894968
Cytokine release syndrome 57.32 10.42 24 531907 14290 62942801
Infection 57.32 10.42 2407 529524 226766 62730325
Insomnia 57.30 10.42 1369 530562 213883 62743208
Gamma-glutamyltransferase increased 57.07 10.42 125 531806 33906 62923185
Blood pressure systolic increased 56.99 10.42 628 531303 46769 62910322
Loss of consciousness 56.85 10.42 674 531257 117447 62839644
Blood creatine phosphokinase increased 56.83 10.42 105 531826 30325 62926766
Respiratory depression 56.55 10.42 22 531909 13693 62943398
Osteoporosis 56.33 10.42 731 531200 56607 62900484
Juvenile idiopathic arthritis 55.65 10.42 100 531831 3226 62953865
Disturbance in attention 55.60 10.42 151 531780 38038 62919053
Restlessness 55.56 10.42 101 531830 29352 62927739
Weight increased 55.40 10.42 2694 529237 258098 62698993
Blood calcium decreased 55.18 10.42 85 531846 26366 62930725
White blood cell count decreased 54.85 10.42 827 531104 138277 62818814
Mydriasis 54.83 10.42 16 531915 11940 62945151
Bone erosion 54.02 10.42 292 531639 17425 62939666
Disorientation 53.04 10.42 162 531769 39290 62917801
Drug level increased 52.46 10.42 68 531863 22668 62934423
Ventricular tachycardia 52.31 10.42 54 531877 19925 62937166
Wrong technique in product usage process 52.21 10.42 307 531624 62033 62895058
Joint laxity 51.75 10.42 82 531849 2382 62954709
Joint range of motion decreased 51.34 10.42 455 531476 31973 62925118
Platelet count decreased 50.50 10.42 677 531254 115445 62841646
Extrapyramidal disorder 50.49 10.42 24 531907 13260 62943831
Disseminated intravascular coagulation 50.44 10.42 51 531880 19000 62938091
Blood pressure decreased 50.41 10.42 328 531603 64694 62892397
Metastases to liver 50.24 10.42 75 531856 23564 62933527
Dysphagia 50.06 10.42 487 531444 88098 62868993
Torsade de pointes 49.41 10.42 25 531906 13326 62943765
Inflammation 49.38 10.42 966 530965 81307 62875784
Joint destruction 49.04 10.42 139 531792 6113 62950978
Mental status changes 48.80 10.42 169 531762 39430 62917661
Caesarean section 48.78 10.42 276 531655 16756 62940335
Acute hepatic failure 48.59 10.42 49 531882 18278 62938813
Drug tolerance decreased 47.99 10.42 280 531651 17193 62939898
Loss of personal independence in daily activities 47.95 10.42 1110 530821 96180 62860911
Cerebral haemorrhage 47.42 10.42 118 531813 30611 62926480
Respiratory disorder 47.35 10.42 168 531763 38914 62918177
Speech disorder 46.38 10.42 179 531752 40450 62916641
Palpitations 46.34 10.42 665 531266 112105 62844986
C-reactive protein increased 46.20 10.42 1079 530852 93628 62863463
Ascites 46.13 10.42 180 531751 40548 62916543
Neurotoxicity 45.53 10.42 45 531886 16945 62940146
Abnormal behaviour 45.52 10.42 68 531863 21358 62935733
Blood alkaline phosphatase increased 45.47 10.42 195 531736 42772 62914319
Injection site reaction 45.46 10.42 716 531215 57808 62899283
Sepsis 45.24 10.42 958 530973 152165 62804926
Hypothermia 45.15 10.42 29 531902 13552 62943539
Emotional distress 44.95 10.42 132 531799 32417 62924674
Urticaria 44.80 10.42 1052 530879 164750 62792341
Accidental exposure to product 44.05 10.42 103 531828 27302 62929789
Polyarthritis 43.88 10.42 185 531746 9961 62947130
Injection site pruritus 43.82 10.42 574 531357 44542 62912549
Inappropriate antidiuretic hormone secretion 43.74 10.42 39 531892 15423 62941668
Muscle spasticity 43.60 10.42 72 531859 21722 62935369
Pulmonary embolism 43.53 10.42 701 531230 115983 62841108
Dysarthria 43.28 10.42 197 531734 42514 62914577
Unresponsive to stimuli 43.25 10.42 142 531789 33674 62923417
Posterior reversible encephalopathy syndrome 43.06 10.42 49 531882 17296 62939795
Schizophrenia 42.66 10.42 15 531916 9937 62947154
Akathisia 42.38 10.42 12 531919 9134 62947957
Myelosuppression 42.33 10.42 84 531847 23619 62933472
Flushing 41.92 10.42 414 531517 74673 62882418
Chronic kidney disease 41.60 10.42 217 531714 45181 62911910
Blood bilirubin increased 41.52 10.42 165 531766 36975 62920116
Depression 41.31 10.42 1292 530639 195200 62761891
Neuroleptic malignant syndrome 41.11 10.42 25 531906 12031 62945060
Disability 41.04 10.42 279 531652 18068 62939023
Withdrawal syndrome 41.01 10.42 65 531866 19932 62937159
Vertigo 40.61 10.42 314 531617 59573 62897518
Fluid retention 40.45 10.42 313 531618 59373 62897718
Blood pressure diastolic decreased 40.39 10.42 327 531604 22379 62934712
Device difficult to use 40.30 10.42 29 531902 12767 62944324
Psychotic disorder 40.25 10.42 98 531833 25614 62931477
Hepatotoxicity 39.87 10.42 167 531764 36874 62920217
Polyneuropathy 39.84 10.42 38 531893 14551 62942540
Rheumatoid nodule 39.65 10.42 263 531668 16892 62940199
Parkinsonism 39.46 10.42 19 531912 10420 62946671
Gestational diabetes 39.40 10.42 157 531774 8239 62948852
Respiratory distress 39.12 10.42 149 531782 33802 62923289
Eosinophilia 38.64 10.42 83 531848 22673 62934418
Neck deformity 38.37 10.42 66 531865 2055 62955036
Toxic skin eruption 38.28 10.42 31 531900 12854 62944237
Bone pain 38.23 10.42 284 531647 54357 62902734
Premature labour 38.07 10.42 206 531725 12298 62944793
Accidental overdose 37.96 10.42 87 531844 23222 62933869
Disease recurrence 37.75 10.42 115 531816 27915 62929176
Foetal exposure during pregnancy 37.74 10.42 422 531509 31540 62925551
Dystonia 37.73 10.42 36 531895 13783 62943308
Stress cardiomyopathy 37.59 10.42 16 531915 9434 62947657
Blood creatinine increased 37.51 10.42 514 531417 87330 62869761
Arrhythmia 37.42 10.42 178 531753 37962 62919129
Thrombotic microangiopathy 37.28 10.42 21 531910 10540 62946551
Tuberculosis 37.09 10.42 189 531742 11022 62946069
Depressed mood 36.89 10.42 192 531739 39999 62917092
Agranulocytosis 36.87 10.42 99 531832 25035 62932056
Adverse event 36.82 10.42 782 531149 66777 62890314
Acute generalised exanthematous pustulosis 36.49 10.42 24 531907 11075 62946016
Multiple fractures 36.39 10.42 156 531775 8462 62948629
Hospitalisation 36.27 10.42 498 531433 84583 62872508
Hypomania 36.23 10.42 5 531926 6325 62950766
Diabetes mellitus inadequate control 36.19 10.42 44 531887 15082 62942009
Product administration error 36.14 10.42 84 531847 22313 62934778
Pain in jaw 35.99 10.42 215 531716 43281 62913810
Haemorrhage 35.95 10.42 332 531599 60690 62896401
Ventricular fibrillation 35.95 10.42 28 531903 11839 62945252
Joint stiffness 35.90 10.42 521 531410 41348 62915743
Dyskinesia 35.88 10.42 142 531789 31860 62925231
Exposure to toxic agent 35.57 10.42 3 531928 5584 62951507
Haematotoxicity 35.54 10.42 17 531914 9359 62947732
Decreased appetite 35.23 10.42 1731 530200 249321 62707770
Cerebrovascular accident 34.84 10.42 666 531265 107358 62849733
Pancreatitis acute 34.80 10.42 114 531817 27052 62930039
Aspartate aminotransferase increased 34.79 10.42 539 531392 89738 62867353
Metastases to central nervous system 34.79 10.42 35 531896 13070 62944021
Alanine aminotransferase increased 34.64 10.42 636 531295 103134 62853957
Nodule 34.31 10.42 297 531634 20729 62936362
Gastrointestinal haemorrhage 34.30 10.42 476 531455 80700 62876391
Gastrointestinal disorder 34.28 10.42 1385 530546 129854 62827237
Face oedema 34.09 10.42 74 531857 20138 62936953
Second primary malignancy 34.06 10.42 12 531919 7941 62949150
Pulmonary oedema 33.88 10.42 295 531636 54578 62902513
Miosis 33.43 10.42 10 531921 7343 62949748
Brain oedema 33.22 10.42 42 531889 14153 62942938
Transplant rejection 33.21 10.42 25 531906 10755 62946336
Hemiparesis 33.19 10.42 93 531838 23189 62933902
Maternal drugs affecting foetus 33.10 10.42 108 531823 5134 62951957
Dysgeusia 33.05 10.42 242 531689 46468 62910623
Mobility decreased 32.90 10.42 1284 530647 119875 62837216
Bronchospasm 32.82 10.42 59 531872 17221 62939870
Laryngitis 32.74 10.42 249 531682 16718 62940373
Hypomagnesaemia 32.55 10.42 127 531804 28610 62928481
Coagulopathy 32.40 10.42 78 531853 20466 62936625
Mania 31.73 10.42 34 531897 12333 62944758
Status epilepticus 31.73 10.42 49 531882 15184 62941907
Lymphocyte count decreased 31.60 10.42 138 531793 30119 62926972
Jaundice 31.41 10.42 132 531799 29119 62927972
Tenderness 31.32 10.42 308 531623 22270 62934821
Atrioventricular block complete 31.21 10.42 15 531916 8236 62948855
Ventricular septal defect 31.14 10.42 94 531837 4284 62952807
Irritability 31.04 10.42 148 531783 31546 62925545
Nightmare 30.96 10.42 72 531859 19122 62937969
Pulmonary arterial hypertension 30.85 10.42 92 531839 22485 62934606
Melaena 30.80 10.42 140 531791 30225 62926866
Musculoskeletal pain 30.75 10.42 1001 530930 91276 62865815
Forced expiratory volume decreased 30.74 10.42 3 531928 4965 62952126
Panic attack 30.52 10.42 91 531840 22240 62934851
Atrial fibrillation 30.40 10.42 744 531187 115892 62841199
Injection site swelling 30.40 10.42 564 531367 47008 62910083
Joint dislocation 30.38 10.42 265 531666 18535 62938556
Pleural effusion 30.26 10.42 574 531357 92636 62864455
Dyspnoea exertional 30.20 10.42 341 531590 59961 62897130
Maternal exposure before pregnancy 30.10 10.42 135 531796 7468 62949623
Proteinuria 29.94 10.42 73 531858 19072 62938019
Device use error 29.76 10.42 6 531925 5755 62951336
Enthesopathy 29.75 10.42 147 531784 8467 62948624
Substance abuse 29.49 10.42 3 531928 4804 62952287
Heart rate decreased 29.41 10.42 541 531390 45019 62912072
International normalised ratio increased 29.37 10.42 248 531683 46177 62910914
Obstructive airways disorder 29.27 10.42 83 531848 20616 62936475
Asphyxia 28.85 10.42 8 531923 6173 62950918
Tumour lysis syndrome 28.80 10.42 20 531911 8970 62948121
Cytopenia 28.55 10.42 33 531898 11568 62945523
Myoclonus 28.54 10.42 56 531875 15812 62941279
Latent tuberculosis 28.49 10.42 66 531865 2561 62954530
Ankylosing spondylitis 28.22 10.42 167 531764 10307 62946784
Pyrexia 28.13 10.42 3482 528449 466996 62490095
Prescribed underdose 28.11 10.42 376 531555 29313 62927778
General physical health deterioration 28.09 10.42 2004 529927 199398 62757693
Hyperlipidaemia 28.03 10.42 78 531853 19493 62937598
Wheelchair user 27.94 10.42 116 531815 6203 62950888
Pain in extremity 27.90 10.42 3179 528752 328307 62628784
Aggression 27.81 10.42 102 531829 23396 62933695
Ischaemic stroke 27.67 10.42 69 531862 17888 62939203
Sinus tachycardia 27.64 10.42 107 531824 24161 62932930
Cardiogenic shock 27.56 10.42 69 531862 17863 62939228
Metastases to lung 27.54 10.42 40 531891 12710 62944381
Haemophagocytic lymphohistiocytosis 27.51 10.42 29 531902 10598 62946493
Blood pressure diastolic increased 27.22 10.42 160 531771 9850 62947241
Erythema multiforme 27.18 10.42 27 531904 10142 62946949
Stevens-Johnson syndrome 27.16 10.42 112 531819 24838 62932253
Localised infection 27.13 10.42 379 531552 29831 62927260
Chest pain 27.07 10.42 1506 530425 214453 62742638
Lupus-like syndrome 27.05 10.42 220 531711 15075 62942016
Cerebral infarction 26.80 10.42 106 531825 23787 62933304
Device related infection 26.73 10.42 103 531828 23289 62933802
Limb deformity 26.68 10.42 84 531847 3918 62953173
Back pain 26.53 10.42 1880 530051 262265 62694826
Product dose omission issue 26.51 10.42 1650 530281 232663 62724428
Aphasia 26.32 10.42 165 531766 32835 62924256
Haemorrhage intracranial 26.23 10.42 45 531886 13374 62943717
Obesity 26.19 10.42 374 531557 29578 62927513
Small for dates baby 26.18 10.42 80 531851 3671 62953420
Graft versus host disease 26.04 10.42 12 531919 6751 62950340
Peripheral venous disease 25.98 10.42 220 531711 15257 62941834
Bradyphrenia 25.93 10.42 13 531918 6967 62950124
Angina pectoris 25.78 10.42 147 531784 29931 62927160
Acute respiratory failure 25.70 10.42 176 531755 34309 62922782
Rash maculo-papular 25.69 10.42 159 531772 31737 62925354
Paralysis 25.65 10.42 27 531904 9873 62947218
Facet joint syndrome 25.63 10.42 182 531749 11956 62945135
Off label use 25.63 10.42 5124 526807 669338 62287753
Acute myeloid leukaemia 25.56 10.42 67 531864 17080 62940011
Tachypnoea 25.49 10.42 68 531863 17234 62939857
Urinary retention 25.48 10.42 149 531782 30152 62926939
Rhinitis allergic 25.12 10.42 37 531894 11690 62945401
Temperature regulation disorder 25.01 10.42 10 531921 6122 62950969
Dry skin 24.96 10.42 331 531600 56556 62900535
Muscle twitching 24.87 10.42 83 531848 19585 62937506
Malignant mediastinal neoplasm 24.87 10.42 44 531887 1402 62955689
Pre-eclampsia 24.85 10.42 146 531785 8987 62948104
Injection site bruising 24.77 10.42 491 531440 41419 62915672
Premature rupture of membranes 24.75 10.42 95 531836 4898 62952193
Tenosynovitis 24.71 10.42 199 531732 13596 62943495
Smear cervix abnormal 24.59 10.42 67 531864 2879 62954212
Lethargy 24.53 10.42 326 531605 55681 62901410
Deep vein thrombosis 24.52 10.42 525 531406 83275 62873816
Injection site pain 24.48 10.42 1326 530605 128474 62828617
Paradoxical drug reaction 24.44 10.42 3 531928 4149 62952942
Haemoptysis 24.29 10.42 141 531790 28585 62928506
Femur fracture 24.28 10.42 488 531443 41268 62915823
Acute graft versus host disease 24.19 10.42 4 531927 4424 62952667
Hallucination, auditory 24.17 10.42 44 531887 12780 62944311
Bronchopulmonary aspergillosis 24.16 10.42 22 531909 8613 62948478
Clostridium difficile colitis 23.87 10.42 90 531841 20479 62936612
Tenosynovitis stenosans 23.71 10.42 72 531859 3292 62953799
Diabetes mellitus 23.66 10.42 327 531604 55483 62901608
Acidosis 23.52 10.42 36 531895 11197 62945894
Neck mass 23.45 10.42 75 531856 3528 62953563
Haematoma 23.40 10.42 183 531748 34637 62922454
Complication of device removal 23.36 10.42 7 531924 5135 62951956
Muscle spasms 23.20 10.42 1070 530861 155080 62802011
Fear 23.20 10.42 62 531869 15704 62941387
Sleep apnoea syndrome 23.06 10.42 146 531785 28987 62928104
Retinitis 23.03 10.42 108 531823 6088 62951003
Exostosis 23.02 10.42 240 531691 17622 62939469
Muscle rigidity 23.00 10.42 38 531893 11462 62945629
Red blood cell sedimentation rate 22.96 10.42 91 531840 4763 62952328
Synovial cyst 22.95 10.42 158 531773 10275 62946816
Delirium 22.94 10.42 292 531639 50249 62906842
Personality disorder 22.86 10.42 10 531921 5801 62951290
Dislocation of vertebra 22.83 10.42 137 531794 8498 62948593
Anuria 22.82 10.42 44 531887 12507 62944584
Myocarditis 22.69 10.42 32 531899 10293 62946798
Rash erythematous 22.64 10.42 237 531694 42273 62914818
Mental disorder 22.58 10.42 126 531805 25793 62931298
Bone marrow failure 22.57 10.42 148 531783 29142 62927949
Febrile bone marrow aplasia 22.55 10.42 17 531914 7308 62949783
Breast cancer stage I 22.51 10.42 15 531916 6874 62950217
Rotator cuff repair 22.47 10.42 53 531878 2081 62955010
Lip dry 22.43 10.42 213 531718 15257 62941834
Purpura 22.42 10.42 38 531893 11347 62945744
Wound infection 22.32 10.42 276 531655 21134 62935957
Crying 22.28 10.42 110 531821 23233 62933858
Skin exfoliation 22.27 10.42 242 531689 42860 62914231
Tardive dyskinesia 22.23 10.42 23 531908 8479 62948612
Colitis 22.16 10.42 280 531651 48248 62908843
Infusion site pain 22.16 10.42 70 531861 16799 62940292
Hallucination, visual 22.04 10.42 85 531846 19213 62937878
Affective disorder 22.02 10.42 12 531919 6134 62950957
Dysmorphism 22.02 10.42 55 531876 2241 62954850
Lip swelling 21.94 10.42 161 531770 30902 62926189
Labelled drug-drug interaction medication error 21.82 10.42 50 531881 13349 62943742
Multiple-drug resistance 21.80 10.42 8 531923 5162 62951929
Skin papilloma 21.80 10.42 91 531840 4878 62952213
Infective pulmonary exacerbation of cystic fibrosis 21.79 10.42 25 531906 8792 62948299
Maternal exposure timing unspecified 21.74 10.42 117 531814 6970 62950121
Anti-cyclic citrullinated peptide antibody 21.71 10.42 113 531818 6645 62950446
Sexual dysfunction 21.58 10.42 5 531926 4354 62952737
Complication of device insertion 21.49 10.42 19 531912 7545 62949546
Hypothyroidism 21.37 10.42 241 531690 42391 62914700
Nasal polyps 21.33 10.42 12 531919 6027 62951064
Placental disorder 21.17 10.42 42 531889 1462 62955629
Skin ulcer 21.16 10.42 491 531440 42554 62914537
Circulatory collapse 21.16 10.42 103 531828 21835 62935256
Injection site rash 21.15 10.42 246 531685 18563 62938528
Gastroenteritis viral 21.15 10.42 297 531634 23403 62933688
Memory impairment 21.06 10.42 689 531242 103569 62853522
Pulmonary hypertension 21.00 10.42 204 531727 36919 62920172
Malignant melanoma 20.99 10.42 165 531766 11191 62945900
Synovial fluid analysis 20.98 10.42 56 531875 2377 62954714
Pathogen resistance 20.81 10.42 14 531917 6384 62950707
Cough 20.79 10.42 2141 529790 290602 62666489
Swollen tongue 20.64 10.42 189 531742 34611 62922480
Body height below normal 20.63 10.42 52 531879 2131 62954960
Psychomotor hyperactivity 20.62 10.42 36 531895 10627 62946464
Dermatitis atopic 20.52 10.42 31 531900 9693 62947398
Leukocytosis 20.52 10.42 130 531801 25805 62931286
Prescribed overdose 20.48 10.42 401 531530 33752 62923339
Glycosylated haemoglobin increased 20.41 10.42 46 531885 12352 62944739
Therapeutic response decreased 20.38 10.42 667 531264 60858 62896233
Hyperprolactinaemia 20.28 10.42 4 531927 3896 62953195
Nervousness 20.27 10.42 164 531767 30815 62926276
Immune reconstitution inflammatory syndrome 20.21 10.42 13 531918 6071 62951020
Abdominal pain 20.20 10.42 2151 529780 291305 62665786
Acute respiratory distress syndrome 20.18 10.42 115 531816 23419 62933672
Developmental hip dysplasia 20.14 10.42 39 531892 1333 62955758
Genital haemorrhage 20.14 10.42 19 531912 7313 62949778
Aspergillus infection 19.94 10.42 23 531908 8070 62949021
Body temperature decreased 19.93 10.42 259 531672 20060 62937031
Pancreatitis 19.89 10.42 290 531641 48765 62908326
Adjustment disorder with depressed mood 19.83 10.42 150 531781 10054 62947037
Ketoacidosis 19.82 10.42 6 531925 4372 62952719
Cardiomyopathy 19.73 10.42 78 531853 17506 62939585
Malaise 19.72 10.42 3122 528809 412832 62544259
Cyanosis 19.72 10.42 74 531857 16861 62940230
Cardiotoxicity 19.71 10.42 25 531906 8413 62948678
Anhedonia 19.50 10.42 39 531892 10935 62946156
Loose body in joint 19.42 10.42 37 531894 1249 62955842
Hemiplegia 19.41 10.42 30 531901 9293 62947798
Sinus bradycardia 19.38 10.42 60 531871 14491 62942600
Hepatitis acute 19.32 10.42 29 531902 9091 62948000
Deep vein thrombosis postoperative 19.29 10.42 162 531769 11207 62945884
Pericardial effusion 19.27 10.42 160 531771 29898 62927193
Arthritis infective 19.23 10.42 106 531825 6372 62950719
Product prescribing error 19.18 10.42 135 531796 26154 62930937
Coronary artery disease 19.13 10.42 176 531755 32201 62924890
Rebound effect 19.09 10.42 7 531924 4519 62952572
Toxic epidermal necrolysis 19.02 10.42 129 531802 25205 62931886
Spinal stenosis 18.98 10.42 200 531731 14725 62942366
Pseudomonas infection 18.95 10.42 41 531890 11172 62945919
Vascular device infection 18.88 10.42 20 531911 7292 62949799
Paranoia 18.69 10.42 44 531887 11635 62945456
Bursitis 18.67 10.42 424 531507 36617 62920474
Blood potassium decreased 18.63 10.42 244 531687 41782 62915309
Synovial disorder 18.58 10.42 48 531883 1997 62955094
Atrioventricular block 18.55 10.42 22 531909 7625 62949466
Cardiac failure acute 18.55 10.42 32 531899 9491 62947600
Hyperthyroidism 18.50 10.42 62 531869 14611 62942480
Pulmonary congestion 18.46 10.42 79 531852 17339 62939752
Foetal anticonvulsant syndrome 18.39 10.42 24 531907 581 62956510
Hypophosphataemia 18.32 10.42 43 531888 11383 62945708
Abdominal distension 18.31 10.42 569 531362 86046 62871045
Tubulointerstitial nephritis 18.31 10.42 95 531836 19808 62937283
Lymphopenia 18.29 10.42 85 531846 18242 62938849
Acute chest syndrome 18.19 10.42 28 531903 793 62956298
Fall 18.13 10.42 2949 528982 389385 62567706
Rheumatoid lung 18.09 10.42 72 531859 3776 62953315
Clear cell renal cell carcinoma 18 10.42 39 531892 1446 62955645
Therapy partial responder 17.99 10.42 39 531892 10619 62946472
Acute myocardial infarction 17.97 10.42 177 531754 31947 62925144
Lymphoedema 17.96 10.42 45 531886 11647 62945444
Hallucinations, mixed 17.93 10.42 9 531922 4820 62952271
Eating disorder 17.93 10.42 90 531841 18926 62938165
Delusion 17.88 10.42 47 531884 11970 62945121
Schizoaffective disorder 17.81 10.42 4 531927 3558 62953533
Subdural haematoma 17.75 10.42 61 531870 14267 62942824
Shock haemorrhagic 17.72 10.42 35 531896 9860 62947231
Bradypnoea 17.72 10.42 4 531927 3546 62953545
Atrial septal defect 17.66 10.42 109 531822 6829 62950262
Epstein-Barr virus infection 17.64 10.42 25 531906 8025 62949066
Blood glucose decreased 17.63 10.42 103 531828 20849 62936242
Graft versus host disease in gastrointestinal tract 17.55 10.42 3 531928 3238 62953853
Antinuclear antibody positive 17.51 10.42 121 531810 7878 62949213
Hepatic cytolysis 17.50 10.42 68 531863 15339 62941752
Hypervolaemia 17.43 10.42 153 531778 28260 62928831
Systemic inflammatory response syndrome 17.36 10.42 13 531918 5608 62951483
Generalised oedema 17.22 10.42 71 531860 15747 62941344
Renal disorder 17.09 10.42 185 531746 32789 62924302
Skin cancer 17.03 10.42 159 531772 11336 62945755
Chills 17.02 10.42 776 531155 112602 62844489
Eosinophil count increased 16.83 10.42 42 531889 10886 62946205
Body temperature increased 16.83 10.42 215 531716 36977 62920114
Jaundice cholestatic 16.80 10.42 22 531909 7302 62949789
Complication associated with device 16.79 10.42 79 531852 16899 62940192
Hepatitis B reactivation 16.77 10.42 3 531928 3134 62953957
Hypophagia 16.76 10.42 174 531757 31085 62926006
Colitis microscopic 16.76 10.42 33 531898 9306 62947785
Transplant dysfunction 16.75 10.42 10 531921 4862 62952229
Ileus 16.72 10.42 65 531866 14660 62942431
Salivary hypersecretion 16.60 10.42 24 531907 7642 62949449
Incorrect product administration duration 16.55 10.42 46 531885 11500 62945591
Sensitisation 16.53 10.42 4 531927 3382 62953709
Multiple drug therapy 16.50 10.42 5 531926 3641 62953450
Klebsiella infection 16.49 10.42 29 531902 8537 62948554
Muscular weakness 16.49 10.42 847 531084 121506 62835585
Aspiration 16.48 10.42 42 531889 10809 62946282
Oliguria 16.47 10.42 32 531899 9069 62948022
Hepatitis cholestatic 16.46 10.42 20 531911 6858 62950233
Neutropenic colitis 16.46 10.42 3 531928 3092 62953999
Macular degeneration 16.43 10.42 128 531803 24248 62932843
Antibody test positive 16.40 10.42 55 531876 2652 62954439
Renal injury 16.38 10.42 34 531897 9405 62947686
Polyhydramnios 16.38 10.42 49 531882 2222 62954869
Human antichimeric antibody positive 16.37 10.42 41 531890 1673 62955418
Polyuria 16.37 10.42 29 531902 8513 62948578
Congenital arterial malformation 16.34 10.42 17 531914 320 62956771
Acute pulmonary oedema 16.27 10.42 27 531904 8131 62948960
Mucosal inflammation 16.16 10.42 286 531645 46642 62910449
Cushingoid 16.08 10.42 124 531807 8361 62948730
Feeling hot 16.06 10.42 311 531620 50043 62907048
Hypertransaminasaemia 16.05 10.42 19 531912 6590 62950501
Urinary incontinence 16.04 10.42 181 531750 31833 62925258
Bradykinesia 16.02 10.42 12 531919 5176 62951915
Laryngospasm 15.97 10.42 3 531928 3025 62954066
Paraesthesia 15.93 10.42 1116 530815 155850 62801241
Toxic encephalopathy 15.89 10.42 19 531912 6560 62950531
Right ventricular failure 15.83 10.42 82 531849 17106 62939985
Renal tubular necrosis 15.80 10.42 49 531882 11829 62945262
Product adhesion issue 15.79 10.42 10 531921 4709 62952382
Tinnitus 15.74 10.42 207 531724 35421 62921670
Treatment noncompliance 15.71 10.42 219 531712 37106 62919985
Product administered to patient of inappropriate age 15.69 10.42 4 531927 3264 62953827
Subarachnoid haemorrhage 15.62 10.42 64 531867 14219 62942872
Scleritis 15.60 10.42 76 531855 4352 62952739
Injury 15.58 10.42 757 531174 72490 62884601
Respiratory acidosis 15.58 10.42 20 531911 6695 62950396
Affect lability 15.56 10.42 45 531886 11106 62945985
Peripheral sensory neuropathy 15.49 10.42 24 531907 7427 62949664
Headache 15.43 10.42 4908 527023 628333 62328758
Fracture delayed union 15.38 10.42 50 531881 2372 62954719
Product preparation error 15.35 10.42 17 531914 6075 62951016
Breast cancer female 15.30 10.42 60 531871 13499 62943592
Bone lesion 15.28 10.42 16 531915 5865 62951226
Dysuria 15.28 10.42 195 531736 33543 62923548
Pallor 15.25 10.42 173 531758 30395 62926696
Epilepsy 15.19 10.42 149 531782 26916 62930175
Presyncope 15.17 10.42 154 531777 27631 62929460
Dermatitis exfoliative 15.16 10.42 14 531917 5445 62951646
Lupus vulgaris 15.15 10.42 94 531837 5900 62951191
Postoperative wound infection 15.14 10.42 149 531782 10776 62946315
Cytomegalovirus viraemia 15.09 10.42 15 531916 5634 62951457
Cholecystitis chronic 15.06 10.42 41 531890 10320 62946771
Sleep disorder due to a general medical condition 15.03 10.42 52 531879 12136 62944955
Multiple allergies 14.99 10.42 62 531869 13740 62943351
Pulseless electrical activity 14.90 10.42 25 531906 7496 62949595
Middle insomnia 14.88 10.42 55 531876 12588 62944503
Fear of injection 14.88 10.42 107 531824 7057 62950034
Tendonitis 14.86 10.42 239 531692 19376 62937715
Pulmonary tuberculosis 14.84 10.42 76 531855 4441 62952650
Blood parathyroid hormone decreased 14.79 10.42 136 531795 9655 62947436
Acute coronary syndrome 14.77 10.42 40 531891 10086 62947005
Stillbirth 14.71 10.42 102 531829 6648 62950443
Hyperuricaemia 14.65 10.42 14 531917 5356 62951735
Breast feeding 14.46 10.42 26 531905 839 62956252
Dementia 14.46 10.42 95 531836 18699 62938392
Haematemesis 14.44 10.42 174 531757 30238 62926853
Hypernatraemia 14.43 10.42 26 531905 7583 62949508
Bundle branch block left 14.42 10.42 23 531908 7036 62950055
Tumour marker increased 14.38 10.42 12 531919 4903 62952188
Myopathy 14.31 10.42 47 531884 11144 62945947
Carotid artery thrombosis 14.25 10.42 3 531928 2791 62954300
Injection site warmth 14.20 10.42 192 531739 15003 62942088
Granuloma skin 14.20 10.42 120 531811 8317 62948774
Ear infection 14.17 10.42 420 531511 37793 62919298
Atrial tachycardia 14.17 10.42 9 531922 4231 62952860
Oedema peripheral 14.13 10.42 1381 530550 188130 62768961
Personality change 13.98 10.42 23 531908 6950 62950141
Illness 13.88 10.42 309 531622 48750 62908341
Exomphalos 13.77 10.42 20 531911 537 62956554
Multiple sclerosis 13.76 10.42 134 531797 24238 62932853
Hypocalcaemia 13.73 10.42 185 531746 31528 62925563
Device breakage 13.72 10.42 50 531881 11492 62945599
Visual impairment 13.70 10.42 573 531358 83873 62873218
Head injury 13.68 10.42 155 531776 27241 62929850
Crohn's disease 13.67 10.42 79 531852 4834 62952257
Hypercholesterolaemia 13.65 10.42 253 531678 21081 62936010
Amylase increased 13.61 10.42 20 531911 6325 62950766
Transaminases increased 13.58 10.42 183 531748 31184 62925907
Wrong product administered 13.53 10.42 19 531912 6122 62950969
Electrocardiogram QRS complex prolonged 13.45 10.42 18 531913 5920 62951171
Nephropathy toxic 13.41 10.42 38 531893 9441 62947650
Inadequate analgesia 13.38 10.42 4 531927 2939 62954152
Colorectal cancer 13.23 10.42 7 531924 3638 62953453
Pulmonary haemorrhage 13.21 10.42 25 531906 7156 62949935
Mood altered 13.21 10.42 71 531860 14672 62942419
Skin toxicity 13.20 10.42 12 531919 4702 62952389
Gastroschisis 13.20 10.42 17 531914 406 62956685
Short stature 13.18 10.42 22 531909 668 62956423
Food allergy 13.16 10.42 50 531881 11351 62945740
Cyst 13.12 10.42 178 531753 13921 62943170
Autism spectrum disorder 13.10 10.42 25 531906 845 62956246
Squamous cell carcinoma 13.09 10.42 120 531811 8512 62948579
Respiration abnormal 13.02 10.42 21 531910 6396 62950695
Glomerular filtration rate decreased 13.02 10.42 63 531868 13378 62943713
Device dislocation 13.01 10.42 145 531786 25560 62931531
Abortion incomplete 12.95 10.42 5 531926 3126 62953965
Pulmonary alveolar haemorrhage 12.93 10.42 12 531919 4656 62952435
Sciatica 12.93 10.42 378 531553 33946 62923145
Erythema 12.93 10.42 1282 530649 174469 62782622
Onychomycosis 12.92 10.42 112 531819 7820 62949271
Metastases to lymph nodes 12.84 10.42 31 531900 8127 62948964
Epistaxis 12.76 10.42 489 531442 72236 62884855
Adenovirus infection 12.75 10.42 7 531924 3564 62953527
Blood lactic acid increased 12.75 10.42 25 531906 7061 62950030
Product substitution issue 12.75 10.42 80 531851 15916 62941175
Visual acuity reduced 12.74 10.42 119 531812 21707 62935384
Hyperthermia 12.74 10.42 37 531894 9119 62947972
Intracranial pressure increased 12.72 10.42 15 531916 5212 62951879
Polydipsia 12.71 10.42 7 531924 3557 62953534
Hypoglycaemic coma 12.66 10.42 3 531928 2572 62954519
Neutrophilia 12.60 10.42 11 531920 4395 62952696
Ulcer 12.59 10.42 297 531634 25810 62931281
Bundle branch block right 12.54 10.42 14 531917 4984 62952107
Coordination abnormal 12.52 10.42 66 531865 13707 62943384
Joint noise 12.46 10.42 71 531860 4321 62952770
Haemorrhage in pregnancy 12.46 10.42 40 531891 1885 62955206
Fracture 12.45 10.42 232 531699 19352 62937739
Product physical issue 12.44 10.42 14 531917 4966 62952125
Lymph gland infection 12.43 10.42 18 531913 482 62956609
Anger 12.29 10.42 58 531873 12398 62944693
Nasal obstruction 12.16 10.42 37 531894 1694 62955397
Blood urea increased 12.12 10.42 152 531779 26227 62930864
Speech disorder developmental 12.09 10.42 21 531910 659 62956432
Ankle arthroplasty 12.04 10.42 38 531893 1775 62955316
Intervertebral disc degeneration 12.03 10.42 192 531739 15540 62941551
Abdominal pain upper 12.03 10.42 1530 530401 204914 62752177
Gestational hypertension 11.99 10.42 46 531885 2371 62954720
Plasma cell myeloma 11.99 10.42 220 531711 35685 62921406
Oligoarthritis 11.99 10.42 19 531912 552 62956539
Learning disorder 11.98 10.42 21 531910 664 62956427
Congenital cerebral cyst 11.96 10.42 13 531918 258 62956833
Cardiac disorder 11.95 10.42 329 531602 50487 62906604
Pregnancy with contraceptive device 11.94 10.42 13 531918 4681 62952410
Progressive multifocal leukoencephalopathy 11.88 10.42 62 531869 12909 62944182
Hypertelorism 11.86 10.42 17 531914 451 62956640
Talipes 11.85 10.42 34 531897 1506 62955585
Infusion site swelling 11.83 10.42 42 531889 9728 62947363
Blood iron increased 11.82 10.42 34 531897 1508 62955583
Post-traumatic stress disorder 11.81 10.42 16 531915 5235 62951856
Pneumonia viral 11.77 10.42 31 531900 7891 62949200
Tongue disorder 11.73 10.42 138 531793 10442 62946649
Blood phosphorus decreased 11.70 10.42 12 531919 4441 62952650
Dactylitis 11.59 10.42 48 531883 2564 62954527
Hyperbilirubinaemia 11.57 10.42 52 531879 11262 62945829
Induced labour 11.56 10.42 25 531906 926 62956165
Sleep terror 11.55 10.42 4 531927 2676 62954415
Premature delivery 11.55 10.42 334 531597 29947 62927144
Panniculitis 11.54 10.42 146 531785 11239 62945852
Joint lock 11.48 10.42 44 531887 2267 62954824
Haemodynamic instability 11.47 10.42 39 531892 9151 62947940
Dermatitis acneiform 11.47 10.42 15 531916 4981 62952110
Blood lactate dehydrogenase increased 11.46 10.42 131 531800 22985 62934106
Ejection fraction 11.44 10.42 3 531928 2403 62954688
Contrast media allergy 11.41 10.42 3 531928 2398 62954693
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.39 10.42 5 531926 2894 62954197
Disturbance in social behaviour 11.38 10.42 10 531921 3983 62953108
Device issue 11.31 10.42 136 531795 23645 62933446
Skin plaque 11.30 10.42 34 531897 8286 62948805
Troponin increased 11.29 10.42 45 531886 10076 62947015
Bacteraemia 11.28 10.42 92 531839 17256 62939835
Ingrown hair 11.27 10.42 19 531912 582 62956509
Nail injury 11.26 10.42 20 531911 639 62956452
Breast cancer metastatic 11.26 10.42 57 531874 11961 62945130
Cyst rupture 11.22 10.42 20 531911 641 62956450
Chronic graft versus host disease 11.19 10.42 6 531925 3096 62953995
Hypoventilation 11.19 10.42 14 531917 4740 62952351
Hepatic necrosis 11.18 10.42 19 531912 5668 62951423
Diabetes insipidus 11.18 10.42 4 531927 2621 62954470
Human anti-human antibody test 11.17 10.42 16 531915 424 62956667
Potentiating drug interaction 11.15 10.42 12 531919 4344 62952747
Nystagmus 11.14 10.42 22 531909 6198 62950893
Ileus paralytic 11.14 10.42 13 531918 4538 62952553
Oropharyngeal pain 11.14 10.42 928 531003 93559 62863532
Lymphatic fistula 11.12 10.42 22 531909 764 62956327
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