levofloxacin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 1569 100986-85-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levofloxacin anhydrous
  • levofloxacin hydrate
  • levaquin
  • oftaquix
  • quixin
  • (S)-Ofloxacin
  • levofloxacin
The L-isomer of Ofloxacin.
  • Molecular weight: 361.37
  • Formula: C18H20FN3O4
  • CLOGP: -0.51
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 73.32
  • ALOGS: -2.40
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.24 g Inhal.solution
0.50 g O
0.50 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 74 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 29.65 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 97.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.90 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.75 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8.80 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 20, 1996 FDA JANSSEN PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 4497.68 27.53 1371 6369 45272 2305073
Tendon rupture 2254.52 27.53 415 7325 1103 2349242
Tendonitis 2242.30 27.53 439 7301 1788 2348557
Arthralgia 1027.69 27.53 494 7246 53791 2296554
Tendon pain 993.10 27.53 183 7557 480 2349865
Tendon disorder 936.51 27.53 180 7560 636 2349709
Rotator cuff syndrome 743.64 27.53 171 7569 1654 2348691
Myalgia 600.55 27.53 264 7476 23069 2327276
Pain in extremity 565.03 27.53 306 7434 42234 2308111
Dyspnoea 510.48 27.53 358 7382 78375 2271970
Drug interaction 455.19 27.53 234 7506 28929 2321416
Rash 444.98 27.53 296 7444 59262 2291083
Neuropathy peripheral 423.60 27.53 168 7572 11264 2339081
Erythema 413.11 27.53 209 7531 24950 2325395
Nausea 406.23 27.53 362 7378 111827 2238518
Pruritus 394.01 27.53 244 7496 43096 2307249
Asthenia 376.19 27.53 244 7496 46682 2303663
Vomiting 360.24 27.53 280 7460 71322 2279023
Drug reaction with eosinophilia and systemic symptoms 351.96 27.53 121 7619 5397 2344948
Urticaria 341.93 27.53 182 7558 24079 2326266
Pain 326.37 27.53 249 7491 61608 2288737
Gait disturbance 320.09 27.53 170 7570 22375 2327970
Electrocardiogram QT prolonged 314.44 27.53 122 7618 7692 2342653
Insomnia 295.99 27.53 169 7571 25618 2324727
Pyrexia 295.91 27.53 222 7518 53486 2296859
Anxiety 288.54 27.53 174 7566 29185 2321160
Paraesthesia 278.49 27.53 154 7586 21934 2328411
Hallucination 267.93 27.53 110 7630 8038 2342307
Confusional state 267.18 27.53 155 7585 24189 2326156
Hypoglycaemia 264.60 27.53 110 7630 8297 2342048
Musculoskeletal pain 263.11 27.53 118 7622 10712 2339633
Meniscus injury 252.56 27.53 65 7675 1033 2349312
Toxic epidermal necrolysis 252.27 27.53 82 7658 3062 2347283
Anaphylactic reaction 249.39 27.53 110 7630 9595 2340750
Tenosynovitis 245.83 27.53 55 7685 461 2349884
Fatigue 238.97 27.53 239 7501 84634 2265711
Torsade de pointes 219.12 27.53 68 7672 2178 2348167
Joint swelling 216.60 27.53 119 7621 16700 2333645
Muscular weakness 215.86 27.53 114 7626 14783 2335562
Dizziness 210.23 27.53 189 7551 58476 2291869
Hypoaesthesia 206.62 27.53 123 7617 20092 2330253
Tendon injury 204.85 27.53 43 7697 257 2350088
Depression 195.09 27.53 134 7606 27998 2322347
Tremor 193.83 27.53 119 7621 20542 2329803
Epicondylitis 191.43 27.53 40 7700 233 2350112
Drug ineffective 185.16 27.53 228 7512 101396 2248949
Delirium 180.09 27.53 73 7667 5150 2345195
Bursitis 178.70 27.53 56 7684 1852 2348493
Seizure 175.41 27.53 119 7621 24347 2325998
Swelling 170.95 27.53 101 7639 16249 2334096
International normalised ratio increased 168.75 27.53 77 7663 7259 2343086
Hypersensitivity 162.59 27.53 112 7628 23481 2326864
Headache 159.05 27.53 188 7552 79991 2270354
Muscle rupture 158.97 27.53 36 7704 320 2350025
Diarrhoea 157.67 27.53 191 7549 83373 2266972
Drug intolerance 154.64 27.53 89 7651 13628 2336717
Stevens-Johnson syndrome 151.89 27.53 61 7679 4198 2346147
Nervous system disorder 151.77 27.53 56 7684 3060 2347285
Hypotension 151.77 27.53 122 7618 32314 2318031
Malaise 151.26 27.53 154 7586 55431 2294914
Oedema peripheral 150.19 27.53 107 7633 23656 2326689
Burning sensation 148.69 27.53 72 7668 7756 2342589
Impaired work ability 148.36 27.53 48 7692 1762 2348583
Neurotoxicity 144.61 27.53 49 7691 2081 2348264
Plantar fasciitis 144.13 27.53 35 7705 432 2349913
Muscle spasms 138.32 27.53 98 7642 21468 2328877
Pneumonia 134.81 27.53 137 7603 49159 2301186
Gait inability 132.20 27.53 61 7679 5894 2344451
Gastrointestinal disorder 131.20 27.53 69 7671 8848 2341497
Ligament rupture 130.81 27.53 33 7707 481 2349864
Disorientation 128.26 27.53 61 7679 6311 2344034
Acute generalised exanthematous pustulosis 127.91 27.53 42 7698 1616 2348729
Myoclonus 126.01 27.53 46 7694 2437 2347908
Decreased appetite 123.19 27.53 103 7637 28788 2321557
Acute kidney injury 121.44 27.53 101 7639 28021 2322324
Cough 120.84 27.53 108 7632 33009 2317336
Respiratory failure 119.35 27.53 75 7665 13453 2336892
Visual impairment 118.58 27.53 71 7669 11684 2338661
Abdominal pain upper 118.15 27.53 90 7650 22010 2328335
Ventricular tachycardia 117.37 27.53 46 7694 2965 2347380
International normalised ratio fluctuation 113.44 27.53 27 7713 304 2350041
Psychotic disorder 110.35 27.53 50 7690 4629 2345716
Tenosynovitis stenosans 107.59 27.53 22 7718 113 2350232
Crystal nephropathy 107.37 27.53 20 7720 56 2350289
Clostridial infection 107.22 27.53 31 7709 773 2349572
Atelectasis 105.66 27.53 38 7702 1927 2348418
Periarthritis 105.04 27.53 26 7714 349 2349996
Hypomagnesaemia 102.86 27.53 40 7700 2524 2347821
Infusion site erythema 101.63 27.53 30 7710 806 2349539
Tachycardia 101.54 27.53 73 7667 16336 2334009
Anaemia 99.21 27.53 99 7641 34693 2315652
Musculoskeletal stiffness 98.33 27.53 64 7676 12183 2338162
Generalised tonic-clonic seizure 97.74 27.53 48 7692 5324 2345021
Status epilepticus 97.08 27.53 38 7702 2440 2347905
Angioedema 95.95 27.53 55 7685 8341 2342004
Drug-induced liver injury 95.12 27.53 42 7698 3657 2346688
Palpitations 94.54 27.53 70 7670 16386 2333959
Agitation 94.28 27.53 60 7680 10991 2339354
Hypokalaemia 93.77 27.53 59 7681 10595 2339750
Muscle twitching 93.05 27.53 38 7702 2727 2347618
Condition aggravated 93.02 27.53 92 7648 31887 2318458
Rash maculo-papular 92.62 27.53 43 7697 4209 2346136
Clostridium difficile colitis 92.59 27.53 35 7705 2044 2348301
Sleep disorder 91.99 27.53 49 7691 6440 2343905
Blood creatinine increased 91.88 27.53 58 7682 10475 2339870
Drug resistance 91.51 27.53 37 7703 2587 2347758
Infection 91.02 27.53 71 7669 17958 2332387
Septic shock 90.90 27.53 50 7690 7004 2343341
Tinnitus 90.79 27.53 45 7695 5090 2345255
Loss of consciousness 90.65 27.53 72 7668 18695 2331650
Feeling abnormal 90.12 27.53 79 7661 23502 2326843
Renal failure 89.06 27.53 69 7671 17280 2333065
Disturbance in attention 86.46 27.53 45 7695 5640 2344705
Mental disorder 85.65 27.53 40 7700 3967 2346378
Joint range of motion decreased 85.39 27.53 32 7708 1824 2348521
Vanishing bile duct syndrome 85.33 27.53 19 7721 155 2350190
Musculoskeletal injury 85.10 27.53 15 7725 27 2350318
Lip oedema 83.95 27.53 26 7714 825 2349520
Chest pain 83.77 27.53 82 7658 28055 2322290
Infusion related reaction 83.09 27.53 53 7687 9743 2340602
Cognitive disorder 83.00 27.53 43 7697 5338 2345007
Movement disorder 82.15 27.53 35 7705 2793 2347552
Muscle atrophy 81.85 27.53 27 7713 1053 2349292
Dysphagia 81.57 27.53 58 7682 12747 2337598
Alanine aminotransferase increased 81.29 27.53 60 7680 13972 2336373
Pseudomembranous colitis 81.22 27.53 23 7717 531 2349814
Factor XIII deficiency 80.29 27.53 13 7727 9 2350336
Aspartate aminotransferase increased 80.05 27.53 57 7683 12555 2337790
Treatment failure 78.93 27.53 46 7694 7193 2343152
Joint injury 77.10 27.53 32 7708 2392 2347953
Bloody discharge 77.09 27.53 17 7723 132 2350213
Hypocoagulable state 77.02 27.53 18 7722 186 2350159
Face oedema 77.00 27.53 37 7703 3911 2346434
Cholestasis 76.00 27.53 36 7704 3685 2346660
Back pain 75.67 27.53 82 7658 31577 2318768
Thrombocytopenia 74.90 27.53 65 7675 19066 2331279
Toxicity to various agents 73.38 27.53 82 7658 32672 2317673
Chest discomfort 72.62 27.53 57 7683 14538 2335807
Loss of personal independence in daily activities 72.17 27.53 39 7701 5272 2345073
Chills 71.53 27.53 58 7682 15494 2334851
Sensory disturbance 71.28 27.53 31 7709 2601 2347744
Dyskinesia 70.23 27.53 37 7703 4752 2345593
Nightmare 70.14 27.53 34 7706 3663 2346682
Computerised tomogram thorax abnormal 69.40 27.53 16 7724 155 2350190
Presyncope 69.22 27.53 34 7706 3769 2346576
Restlessness 69.04 27.53 36 7704 4527 2345818
Hypoxia 69.02 27.53 40 7700 6187 2344158
Pharyngeal oedema 68.92 27.53 33 7707 3460 2346885
Blister 68.50 27.53 41 7699 6730 2343615
Haematoma 67.90 27.53 37 7703 5084 2345261
Hyperhidrosis 67.75 27.53 56 7684 15366 2334979
Abdominal pain 66.83 27.53 80 7660 34294 2316051
Hepatitis 65.74 27.53 39 7701 6298 2344047
Hypertension 65.60 27.53 71 7669 27290 2323055
Cardiac arrest 65.14 27.53 54 7686 14876 2335469
Joint stiffness 64.49 27.53 33 7707 3990 2346355
Hallucination, visual 64.47 27.53 30 7710 2949 2347396
Immune reconstitution inflammatory syndrome associated tuberculosis 64.31 27.53 12 7728 34 2350311
Multiple organ dysfunction syndrome 63.94 27.53 41 7699 7600 2342745
Neck pain 63.66 27.53 41 7699 7656 2342689
Skin exfoliation 63.66 27.53 37 7703 5753 2344592
Upper respiratory tract infection 63.16 27.53 43 7697 8808 2341537
Kounis syndrome 62.61 27.53 16 7724 246 2350099
Hepatic function abnormal 61.91 27.53 37 7703 6055 2344290
Drug eruption 61.91 27.53 30 7710 3229 2347116
Depressed level of consciousness 61.65 27.53 40 7700 7564 2342781
Eosinophilia 61.47 27.53 29 7711 2941 2347404
Cardiovascular disorder 61.38 27.53 27 7713 2328 2348017
Swollen tongue 61.02 27.53 35 7705 5308 2345037
Encephalopathy 60.59 27.53 33 7707 4528 2345817
Asthma 60.22 27.53 46 7694 11268 2339077
Epilepsy 60.07 27.53 33 7707 4606 2345739
Muscle contractions involuntary 59.92 27.53 18 7722 514 2349831
Anaphylactic shock 59.70 27.53 32 7708 4254 2346091
Peripheral coldness 59.69 27.53 24 7716 1653 2348692
Respiratory tract infection 58.71 27.53 31 7709 3998 2346347
Acute respiratory distress syndrome 58.63 27.53 29 7711 3263 2347082
Carpal tunnel syndrome 58.61 27.53 25 7715 2000 2348345
Paranoia 57.65 27.53 25 7715 2082 2348263
Jaundice 57.40 27.53 34 7706 5474 2344871
Haemophagocytic lymphohistiocytosis 56.97 27.53 22 7718 1361 2348984
Atrial fibrillation 56.34 27.53 48 7692 13720 2336625
Tongue oedema 55.50 27.53 19 7721 831 2349514
Affective disorder 55.46 27.53 19 7721 833 2349512
Influenza B virus test positive 55.40 27.53 10 7730 22 2350323
Lyme disease 55.28 27.53 16 7724 400 2349945
Abortion spontaneous 55.28 27.53 47 7693 13398 2336947
Anosmia 55.03 27.53 19 7721 853 2349492
Rash erythematous 54.84 27.53 34 7706 5942 2344403
Hypoglycaemic coma 54.59 27.53 17 7723 549 2349796
Respiratory muscle weakness 54.37 27.53 11 7729 53 2350292
Respiratory distress 54.33 27.53 32 7708 5097 2345248
Contrast media allergy 54.26 27.53 14 7726 224 2350121
Systemic inflammatory response syndrome 53.12 27.53 18 7722 763 2349582
Toxic skin eruption 52.79 27.53 24 7716 2236 2348109
Wheezing 52.77 27.53 34 7706 6350 2343995
Haemoglobin decreased 52.30 27.53 52 7688 18099 2332246
Skin injury 51.96 27.53 14 7726 267 2350078
Joint effusion 51.50 27.53 20 7720 1256 2349089
Amnesia 51.18 27.53 35 7705 7218 2343127
Ventricular fibrillation 50.23 27.53 23 7717 2178 2348167
Weight decreased 50.21 27.53 63 7677 28308 2322037
Dehydration 50.20 27.53 56 7684 22239 2328106
Rash pruritic 49.98 27.53 35 7705 7500 2342845
Syncope 49.83 27.53 49 7691 16826 2333519
Vision blurred 49.78 27.53 46 7694 14622 2335723
Complex regional pain syndrome 49.65 27.53 14 7726 318 2350027
Urinary tract infection 49.07 27.53 64 7676 29878 2320467
Pancytopenia 49.06 27.53 41 7699 11411 2338934
Interstitial lung disease 48.84 27.53 35 7705 7777 2342568
Polyneuropathy 48.50 27.53 21 7719 1742 2348603
Blood sodium decreased 48.45 27.53 25 7715 3075 2347270
Dysphonia 47.99 27.53 32 7708 6332 2344013
Speech disorder 47.53 27.53 32 7708 6432 2343913
Infusion site pruritus 47.38 27.53 13 7727 266 2350079
Ectropion 46.90 27.53 10 7730 65 2350280
Leukopenia 46.81 27.53 38 7702 10158 2340187
Clostridium colitis 46.45 27.53 13 7727 287 2350058
Hepatitis cholestatic 46.22 27.53 18 7722 1139 2349206
Fall 46.02 27.53 79 7661 47020 2303325
Skin reaction 45.99 27.53 21 7719 1976 2348369
Arthritis 45.44 27.53 37 7703 9931 2340414
Joint noise 44.88 27.53 15 7725 609 2349736
Transaminases increased 44.38 27.53 27 7713 4560 2345785
Rhabdomyolysis 44.13 27.53 31 7709 6673 2343672
Dysstasia 43.92 27.53 23 7717 2916 2347429
Hepatic failure 43.85 27.53 29 7711 5660 2344685
Respiratory syncytial virus infection 43.71 27.53 15 7725 661 2349684
Renal impairment 42.96 27.53 36 7704 10056 2340289
Mobility decreased 42.92 27.53 34 7706 8776 2341569
Memory impairment 42.83 27.53 40 7700 12883 2337462
Throat tightness 42.63 27.53 26 7714 4410 2345935
Trimethylaminuria 42.06 27.53 7 7733 7 2350338
Mental status changes 41.92 27.53 28 7712 5554 2344791
Megacolon 41.89 27.53 12 7728 289 2350056
Fibromyalgia 41.41 27.53 23 7717 3277 2347068
C-reactive protein increased 41.35 27.53 29 7711 6226 2344119
Liver function test abnormal 41.05 27.53 31 7709 7459 2342886
Loss of employment 40.68 27.53 10 7730 130 2350215
Muscle tightness 40.65 27.53 19 7721 1886 2348459
Impaired driving ability 40.62 27.53 16 7724 1043 2349302
Gastroenteritis 40.25 27.53 22 7718 3038 2347307
Aphasia 40.12 27.53 26 7714 4902 2345443
Panic attack 40.12 27.53 24 7716 3932 2346413
Muscle strain 39.91 27.53 16 7724 1093 2349252
Gamma-glutamyltransferase increased 39.62 27.53 27 7713 5535 2344810
Ligament injury 39.55 27.53 10 7730 147 2350198
Sepsis 39.16 27.53 45 7695 18443 2331902
Hypokinesia 39.00 27.53 18 7722 1736 2348609
Oedema 38.55 27.53 34 7706 10169 2340176
Lymphocyte count decreased 38.31 27.53 22 7718 3341 2347004
Staphylococcal infection 38.28 27.53 26 7714 5300 2345045
Muscle injury 37.93 27.53 11 7729 277 2350068
Rheumatoid arthritis 37.89 27.53 45 7695 19095 2331250
Crying 37.78 27.53 24 7716 4372 2345973
Conjunctival hyperaemia 37.51 27.53 13 7727 590 2349755
Myositis 37.04 27.53 16 7724 1319 2349026
Ventricular extrasystoles 37.04 27.53 18 7722 1948 2348397
Enterocolitis 36.88 27.53 14 7726 826 2349519
Neutropenia 36.76 27.53 47 7693 21501 2328844
Somnolence 36.61 27.53 49 7691 23436 2326909
Osteoarthritis 36.42 27.53 28 7712 6918 2343427
Neuralgia 36.32 27.53 20 7720 2802 2347543
Abdominal discomfort 36.15 27.53 42 7698 17414 2332931
Petechiae 36.14 27.53 18 7722 2054 2348291
Heart rate increased 36.08 27.53 34 7706 11071 2339274
Alopecia 35.98 27.53 47 7693 21954 2328391
Clostridium difficile infection 35.88 27.53 20 7720 2870 2347475
Altered state of consciousness 35.50 27.53 22 7718 3838 2346507
Paralysis 35.09 27.53 17 7723 1827 2348518
Infusion site reaction 35.06 27.53 10 7730 237 2350108
Prurigo 34.94 27.53 10 7730 240 2350105
Shock 34.76 27.53 22 7718 3982 2346363
Quadriplegia 34.53 27.53 11 7729 383 2349962
Lymphadenopathy 34.40 27.53 25 7715 5673 2344672
Metabolic encephalopathy 34.32 27.53 12 7728 559 2349786
Renal necrosis 34.22 27.53 7 7733 36 2350309
Nervousness 34.16 27.53 24 7716 5165 2345180
Flushing 34.16 27.53 34 7706 11837 2338508
Balance disorder 33.90 27.53 31 7709 9716 2340629
Hyperpyrexia 33.72 27.53 12 7728 589 2349756
Blood glucose decreased 33.68 27.53 20 7720 3232 2347113
Weight bearing difficulty 33.66 27.53 11 7729 416 2349929
Photosensitivity reaction 33.45 27.53 18 7722 2409 2347936
Lip swelling 33.38 27.53 23 7717 4798 2345547
Tubulointerstitial nephritis 33.38 27.53 18 7722 2420 2347925
Hepatitis B 33.31 27.53 13 7727 827 2349518
Foreign body aspiration 33.21 27.53 8 7732 95 2350250
Arthropathy 33.01 27.53 27 7713 7289 2343056
Eosinophilic pneumonia 33.00 27.53 11 7729 443 2349902
Bedridden 32.79 27.53 15 7725 1417 2348928
Swelling face 32.64 27.53 30 7710 9463 2340882
Erythema multiforme 32.43 27.53 17 7723 2158 2348187
Hepatotoxicity 32.42 27.53 20 7720 3461 2346884
Bronchospasm 32.37 27.53 19 7721 3005 2347340
Trigger finger 32.28 27.53 11 7729 474 2349871
Creatinine renal clearance decreased 32.22 27.53 13 7727 903 2349442
Discomfort 31.98 27.53 23 7717 5136 2345209
Dysbiosis 31.90 27.53 7 7733 53 2350292
Bronchitis 31.80 27.53 35 7705 13679 2336666
Acute psychosis 31.79 27.53 11 7729 497 2349848
Psychomotor hyperactivity 31.48 27.53 16 7724 1906 2348439
Liver injury 31.44 27.53 17 7723 2297 2348048
Blood pressure decreased 31.39 27.53 29 7711 9207 2341138
Sinusitis 31.31 27.53 38 7702 16488 2333857
Blood bilirubin increased 31.25 27.53 23 7717 5322 2345023
Injury 31.21 27.53 24 7716 5930 2344415
Orthostatic hypotension 30.58 27.53 18 7722 2861 2347484
Limb discomfort 30.42 27.53 19 7721 3360 2346985
Hypocalcaemia 30.42 27.53 20 7720 3863 2346482
Retching 30.04 27.53 16 7724 2098 2348247
Therapeutic product effect incomplete 30.00 27.53 30 7710 10501 2339844
Hepatic enzyme increased 29.92 27.53 29 7711 9773 2340572
Red blood cell sedimentation rate increased 29.88 27.53 16 7724 2121 2348224
Hypophagia 29.88 27.53 20 7720 3980 2346365
Nerve injury 29.83 27.53 13 7727 1095 2349250
Haemorrhage intracranial 29.63 27.53 17 7723 2577 2347768
Platelet count decreased 29.37 27.53 36 7704 15777 2334568
Blood urea increased 29.29 27.53 19 7721 3586 2346759
Sputum discoloured 29.19 27.53 13 7727 1153 2349192
Hyponatraemia 29.17 27.53 33 7707 13292 2337053
Infective exacerbation of chronic obstructive airways disease 29.05 27.53 8 7732 166 2350179
Purpura fulminans 28.99 27.53 6 7734 33 2350312
Cyanosis 28.90 27.53 18 7722 3167 2347178
Eye disorder 28.73 27.53 18 7722 3201 2347144
Hyperbilirubinaemia 28.63 27.53 14 7726 1535 2348810
Medication error 28.44 27.53 23 7717 6108 2344237
Factor V inhibition 28.41 27.53 6 7734 37 2350308
Exposure during pregnancy 28.22 27.53 45 7695 25174 2325171
Coma 28.03 27.53 27 7713 9029 2341316
Laryngeal oedema 27.95 27.53 13 7727 1275 2349070
Mental impairment 27.89 27.53 16 7724 2424 2347921
Meningitis tuberculous 27.80 27.53 7 7733 101 2350244
Oropharyngeal pain 27.76 27.53 30 7710 11488 2338857
Psychotic symptom 27.75 27.53 8 7732 197 2350148
Dysgeusia 27.67 27.53 26 7714 8433 2341912

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tendon rupture 2508.18 32.00 477 5104 1295 1739905
Tendonitis 1630.43 32.00 322 5259 1111 1740089
Drug hypersensitivity 786.12 32.00 297 5284 14838 1726362
Rotator cuff syndrome 702.63 32.00 149 5432 776 1740424
Tendon disorder 676.98 32.00 131 5450 385 1740815
Tendon pain 480.07 32.00 98 5483 406 1740794
Neuropathy peripheral 340.09 32.00 142 5439 9111 1732089
Rash 339.43 32.00 227 5354 38466 1702734
Pain in extremity 338.90 32.00 175 5406 18297 1722903
Electrocardiogram QT prolonged 312.44 32.00 116 5465 5429 1735771
Arthralgia 297.14 32.00 174 5407 23270 1717930
Drug interaction 283.82 32.00 180 5401 27778 1713422
Acute kidney injury 277.52 32.00 193 5388 34751 1706449
Urticaria 277.42 32.00 134 5447 12107 1729093
Hypoglycaemia 255.53 32.00 113 5468 8325 1732875
Pyrexia 243.42 32.00 200 5381 46200 1695000
Pruritus 209.46 32.00 139 5442 23083 1718117
Drug ineffective 206.98 32.00 210 5371 63591 1677609
Dyspnoea 205.63 32.00 191 5390 51868 1689332
Erythema 205.29 32.00 115 5466 14073 1727127
Drug reaction with eosinophilia and systemic symptoms 200.13 32.00 82 5499 4988 1736212
Joint injury 190.87 32.00 54 5527 1037 1740163
Hypersensitivity 179.72 32.00 95 5486 10349 1730851
International normalised ratio increased 179.19 32.00 88 5493 8211 1732989
Tenosynovitis 175.72 32.00 39 5542 257 1740943
Myalgia 171.43 32.00 106 5475 15552 1725648
Tendon injury 163.01 32.00 34 5547 159 1741041
Pneumonia 154.77 32.00 155 5426 46027 1695173
Vomiting 153.64 32.00 142 5439 38173 1703027
Delirium 150.98 32.00 72 5509 6290 1734910
Drug resistance 150.84 32.00 59 5522 3171 1738029
Muscle rupture 146.74 32.00 37 5544 446 1740754
Paraesthesia 146.38 32.00 83 5498 10368 1730832
Confusional state 144.15 32.00 107 5474 21171 1720029
Drug-induced liver injury 143.69 32.00 57 5524 3180 1738020
Pain 143.58 32.00 117 5464 26540 1714660
Seizure 143.44 32.00 105 5476 20336 1720864
Nausea 143.18 32.00 156 5425 51040 1690160
Torsade de pointes 142.33 32.00 45 5536 1279 1739921
Epicondylitis 138.79 32.00 28 5553 107 1741093
Nervous system disorder 129.47 32.00 49 5532 2405 1738795
Meniscus injury 129.16 32.00 32 5549 357 1740843
Diarrhoea 128.26 32.00 151 5430 53701 1687499
Ligament rupture 123.92 32.00 28 5553 202 1740998
Asthenia 122.67 32.00 120 5461 34550 1706650
Thrombocytopenia 122.26 32.00 97 5484 21152 1720048
Bursitis 121.16 32.00 34 5547 632 1740568
Anxiety 120.86 32.00 85 5496 15442 1725758
Oedema peripheral 118.42 32.00 84 5497 15466 1725734
Tubulointerstitial nephritis 117.17 32.00 48 5533 2910 1738290
Hypoaesthesia 116.25 32.00 70 5511 9765 1731435
Cholestasis 113.69 32.00 50 5531 3615 1737585
Condition aggravated 112.02 32.00 92 5489 21058 1720142
Toxic epidermal necrolysis 109.58 32.00 43 5538 2328 1738872
Eosinophilia 109.03 32.00 48 5533 3479 1737721
Muscular weakness 108.52 32.00 68 5513 10181 1731019
Renal failure 105.83 32.00 87 5494 19930 1721270
Respiratory failure 105.01 32.00 76 5505 14429 1726771
Tremor 102.41 32.00 72 5509 13059 1728141
Rhabdomyolysis 101.17 32.00 67 5514 11023 1730177
Anaphylactic reaction 100.49 32.00 54 5527 6059 1735141
Insomnia 97.20 32.00 76 5505 16200 1725000
Pathogen resistance 96.60 32.00 32 5549 1057 1740143
Depression 95.60 32.00 76 5505 16593 1724607
Plantar fasciitis 94.07 32.00 22 5559 188 1741012
Anaemia 93.12 32.00 96 5485 29361 1711839
Gait disturbance 93.09 32.00 67 5514 12603 1728597
Dizziness 91.08 32.00 102 5479 34259 1706941
Disorientation 89.01 32.00 48 5533 5421 1735779
Hepatotoxicity 88.98 32.00 40 5541 3044 1738156
Decreased appetite 86.85 32.00 84 5497 23787 1717413
Metabolic acidosis 86.77 32.00 47 5534 5355 1735845
Myoclonus 86.66 32.00 36 5545 2259 1738941
Blood creatinine increased 85.15 32.00 66 5515 13880 1727320
Rash maculo-papular 85.01 32.00 41 5540 3662 1737538
Angioedema 84.78 32.00 57 5524 9607 1731593
Multiple organ dysfunction syndrome 84.66 32.00 56 5525 9186 1732014
Hepatocellular injury 84.07 32.00 39 5542 3192 1738008
Sepsis 79.48 32.00 73 5508 19365 1721835
Respiratory distress 77.66 32.00 43 5538 5114 1736086
Clostridium difficile colitis 77.31 32.00 30 5551 1574 1739626
Fixed eruption 76.18 32.00 19 5562 218 1740982
Therapeutic product cross-reactivity 74.29 32.00 19 5562 243 1740957
Hepatitis 73.74 32.00 41 5540 4914 1736286
Stevens-Johnson syndrome 73.54 32.00 36 5545 3321 1737879
Eosinophilic pneumonia acute 73.20 32.00 16 5565 97 1741103
Alanine aminotransferase increased 72.53 32.00 57 5524 12221 1728979
Clostridial infection 71.65 32.00 23 5558 686 1740514
Tachycardia 71.12 32.00 57 5524 12571 1728629
Hallucination, visual 69.65 32.00 32 5549 2560 1738640
Blood bilirubin increased 67.68 32.00 42 5539 6168 1735032
Clostridium difficile infection 67.44 32.00 28 5553 1753 1739447
Muscle spasms 66.59 32.00 53 5528 11568 1729632
Haematoma 65.22 32.00 35 5546 3910 1737290
Psychotic disorder 64.93 32.00 38 5543 5018 1736182
Chorea 64.59 32.00 17 5564 245 1740955
Arrhythmia 63.83 32.00 40 5541 5976 1735224
Hypotension 63.51 32.00 79 5502 29575 1711625
Ballismus 62.47 32.00 12 5569 33 1741167
Lip oedema 62.41 32.00 20 5561 593 1740607
Palatal oedema 60.45 32.00 16 5565 236 1740964
Visual impairment 60.14 32.00 39 5542 6179 1735021
Drug eruption 59.99 32.00 30 5551 2896 1738304
Musculoskeletal injury 59.72 32.00 11 5570 22 1741178
Musculoskeletal pain 59.59 32.00 36 5545 5038 1736162
Aspartate aminotransferase increased 59.37 32.00 48 5533 10708 1730492
Loss of consciousness 59.08 32.00 55 5526 14820 1726380
Skin injury 58.35 32.00 15 5566 196 1741004
Swelling 58.31 32.00 40 5541 6956 1734244
Acute generalised exanthematous pustulosis 57.69 32.00 22 5559 1100 1740100
Purpura 57.57 32.00 25 5556 1749 1739451
Weight decreased 57.55 32.00 66 5515 22687 1718513
Tinnitus 57.49 32.00 30 5551 3165 1738035
Bronchitis 57.32 32.00 36 5545 5396 1735804
Joint swelling 56.95 32.00 38 5543 6315 1734885
Hypokalaemia 56.84 32.00 38 5543 6336 1734864
Toxic skin eruption 56.14 32.00 25 5556 1858 1739342
Ventricular tachycardia 55.34 32.00 31 5550 3767 1737433
Septic shock 55.24 32.00 41 5540 8068 1733132
Dysphonia 54.48 32.00 30 5551 3525 1737675
Burning sensation 54.31 32.00 29 5552 3206 1737994
Dermatitis exfoliative generalised 54.19 32.00 16 5565 358 1740842
Encephalopathy 53.34 32.00 32 5549 4420 1736780
Tuberculosis 53.16 32.00 24 5557 1842 1739358
Mental disorder 52.03 32.00 27 5554 2816 1738384
Leukocytosis 51.91 32.00 29 5552 3504 1737696
Kounis syndrome 51.74 32.00 16 5565 421 1740779
Gastrointestinal disorder 51.44 32.00 32 5549 4716 1736484
Generalised tonic-clonic seizure 50.87 32.00 30 5551 4016 1737184
Liver function test abnormal 50.72 32.00 34 5547 5692 1735508
Demodicidosis 50.70 32.00 9 5572 13 1741187
Palpitations 49.91 32.00 36 5545 6778 1734422
Hypersensitivity vasculitis 49.55 32.00 20 5561 1164 1740036
Toxicity to various agents 49.03 32.00 69 5512 29072 1712128
Atrial fibrillation 48.99 32.00 50 5531 15061 1726139
Dermatitis bullous 48.91 32.00 20 5561 1204 1739996
Abdominal pain 48.79 32.00 59 5522 21431 1719769
Cardiac arrest 48.57 32.00 51 5530 15879 1725321
Tendon discomfort 48.24 32.00 10 5571 45 1741155
Face oedema 48.03 32.00 24 5557 2312 1738888
Blister 47.95 32.00 29 5552 4063 1737137
Thrombotic microangiopathy 47.82 32.00 20 5561 1275 1739925
Long QT syndrome 47.77 32.00 14 5567 305 1740895
Brain abscess 46.86 32.00 15 5566 443 1740757
Paradoxical drug reaction 45.53 32.00 15 5566 486 1740714
Skin exfoliation 45.21 32.00 29 5552 4506 1736694
Shock 44.96 32.00 28 5553 4133 1737067
Oedema 44.80 32.00 34 5547 6914 1734286
Jaundice 44.33 32.00 32 5549 6030 1735170
Transaminases increased 43.95 32.00 27 5554 3890 1737310
Haemoglobin decreased 43.84 32.00 50 5531 17064 1724136
Chronic pigmented purpura 43.69 32.00 9 5572 39 1741161
Anaphylactic shock 43.15 32.00 24 5557 2875 1738325
Fibromyalgia 43.01 32.00 13 5568 316 1740884
Candida infection 42.87 32.00 21 5560 1937 1739263
Injury 42.68 32.00 24 5557 2936 1738264
Osteoarthritis 42.57 32.00 22 5559 2274 1738926
Malaise 42.48 32.00 65 5516 29500 1711700
Gait inability 42.44 32.00 25 5556 3338 1737862
Tuberculoma of central nervous system 42.31 32.00 9 5572 47 1741153
Ventricular fibrillation 41.52 32.00 23 5558 2733 1738467
Dehydration 40.91 32.00 49 5532 17609 1723591
Throat tightness 40.61 32.00 19 5562 1583 1739617
Headache 40.43 32.00 69 5512 34307 1706893
Product use in unapproved indication 39.64 32.00 36 5545 9386 1731814
Cough 39.21 32.00 50 5531 19147 1722053
Sensitisation 39.15 32.00 8 5573 33 1741167
Acute hepatic failure 39.10 32.00 20 5561 2023 1739177
Hyponatraemia 39.07 32.00 35 5546 8965 1732235
Tongue oedema 38.76 32.00 14 5567 600 1740600
Bronchospasm 38.74 32.00 20 5561 2062 1739138
Rash erythematous 38.65 32.00 25 5556 3940 1737260
Arthropathy 37.99 32.00 22 5559 2845 1738355
Eyelid oedema 37.76 32.00 17 5564 1296 1739904
Pancytopenia 37.56 32.00 38 5543 11319 1729881
Nephrogenic diabetes insipidus 37.52 32.00 11 5570 240 1740960
Deafness 36.91 32.00 19 5562 1947 1739253
Rash pruritic 36.89 32.00 25 5556 4257 1736943
Leukopenia 36.85 32.00 33 5548 8447 1732753
Renal impairment 36.76 32.00 39 5542 12275 1728925
Cartilage injury 36.51 32.00 9 5572 98 1741102
Muscle atrophy 36.05 32.00 16 5565 1179 1740021
Hallucination 35.91 32.00 32 5549 8138 1733062
Eosinophilic pneumonia 35.67 32.00 13 5568 572 1740628
Dysphagia 35.42 32.00 35 5546 10133 1731067
Blood lactate dehydrogenase increased 35.39 32.00 23 5558 3652 1737548
Muscle injury 35.37 32.00 11 5570 295 1740905
Aortic aneurysm 35.25 32.00 15 5566 998 1740202
Interstitial lung disease 34.94 32.00 34 5547 9662 1731538
Anaphylactoid reaction 34.69 32.00 13 5568 619 1740581
Infusion site pruritus 34.34 32.00 8 5573 67 1741133
Distributive shock 34.30 32.00 9 5572 128 1741072
Cardio-respiratory arrest 34.26 32.00 33 5548 9260 1731940
Crystal nephropathy 33.93 32.00 8 5573 71 1741129
Gastrointestinal motility disorder 33.58 32.00 11 5570 350 1740850
Coagulopathy 33.33 32.00 20 5561 2761 1738439
Bicytopenia 33.24 32.00 10 5571 239 1740961
Clostridium colitis 32.97 32.00 10 5571 246 1740954
Wheezing 32.84 32.00 23 5558 4130 1737070
Hyperhidrosis 32.84 32.00 37 5544 12451 1728749
Hyperlactacidaemia 32.58 32.00 11 5570 385 1740815
Blood alkaline phosphatase increased 32.55 32.00 25 5556 5170 1736030
Aggression 32.17 32.00 30 5551 8085 1733115

Pharmacologic Action:

SourceCodeDescription
ATC A02BD10 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
ATC J01MA12 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Fluoroquinolones
ATC J01RA05 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
ATC S01AE05 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Fluoroquinolones
FDA EPC N0000175937 Quinolone Antimicrobial
FDA Chemical/Ingredient N0000007606 Quinolones
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000892 Anti-Infective Agents, Urinary
MeSH PA D000970 Antineoplastic Agents
MeSH PA D065609 Cytochrome P-450 CYP1A2 Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
CHEBI has role CHEBI:36047 antibacterial drug
MeSH PA D059005 Topoisomerase II Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Infection of skin AND/OR subcutaneous tissue indication 19824006
Staphylococcal pneumonia indication 22754005
Pneumonia due to Streptococcus indication 34020007
Pyelonephritis indication 45816000 DOID:11400
Pneumonia due to Mycoplasma pneumoniae indication 46970008
Bacterial pneumonia indication 53084003 DOID:874
Klebsiella cystitis indication 60867007
Acute maxillary sinusitis indication 68272006 DOID:2050
Haemophilus influenzae pneumonia indication 70036007
Acute bacterial sinusitis indication 75498004
Bacterial conjunctivitis indication 128350005 DOID:9700
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Acute Moraxella catarrhalis bronchitis indication 195722003
Acute bacterial bronchitis indication 233598009
Pneumococcal pneumonia indication 233607000
Chlamydial pneumonia indication 233609002
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Streptococcus pyogenes infection indication 302809008
Bacterial urinary infection indication 312124009
Infection due to Staphylococcus aureus indication 406602003
Anthrax indication 409498004 DOID:7427
Acute exacerbation of chronic bronchitis indication 425748003
E. Coli Pyelonephritis indication
Pseudomonas Aeruginosa Urinary Tract Infection indication
Complicated Skin and Skin Structure Proteus Infection indication
Staphylococcus Aureus Bronchitis indication
Nosocomial Pneumonia due to Methicillin-Sensitive Staphylococcus Aureus indication
Haemophilus Influenzae Bronchitis indication
Chronic Enterococcus faecalis Prostatitis indication
Nosocomial Pneumonia due to Streptococcus Pneumoniae indication
Haemophilus Parainfluenzae Bronchitis indication
Synergy for Nosocomial Pneumonia due to Pseudomonas Aeruginosa indication
Haemophilus Parainfluenzae Pneumonia indication
Complicated Skin and Skin Structure Streptococcus Pyogenes Infection indication
Chronic Staphylococcus epidermidis Prostatitis indication
Staphylococcus Saprophyticus Urinary Tract Infection indication
Bacterial Corneal Ulcer Infection indication
Chronic Escherichia coli Prostatitis indication
Complicated Skin and Skin Structure Staphylococcus Aureus Infection indication
Complicated Urinary Tract Infections indication
Enterococcus Urinary Tract Infection indication
Moraxella Catarrhalis Pneumonia indication
Nosocomial Pneumonia due to Klebsiella Pneumoniae indication
Complicated Skin and Skin Structure Enterococcus Faecalis Infection indication
Nosocomial Pneumonia due to Escherichia Coli indication
Streptococcus Pneumoniae Bronchitis indication
Legionella Pneumophila Pneumonia indication
Complicated Skin and Skin Structure Infection indication
Gram-Negative Aerobic Bacillary Pneumonia indication
Nosocomial Pneumonia due to Haemophilus Influenzae indication
Nosocomial Pneumonia due to Serratia Marcescens indication
Traveler's diarrhea off-label use 11840006
Acute tuberculosis off-label use 25629007
Pulmonary tuberculosis off-label use 154283005 DOID:2957
Diabetic Foot Infection off-label use
Hallucinations contraindication 7011001
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Torsades de pointes contraindication 31722008
Transplantation of heart contraindication 32413006
Tendinitis contraindication 34840004 DOID:971
Hypokalemia contraindication 43339004
Bradycardia contraindication 48867003
Transplant of kidney contraindication 70536003
Diabetes mellitus contraindication 73211009 DOID:9351
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Transplant of lung contraindication 88039007
Myasthenia gravis contraindication 91637004 DOID:437
Prolonged QT interval contraindication 111975006
Pancytopenia contraindication 127034005 DOID:12450
Impaired renal function disorder contraindication 197663003
Disease of liver contraindication 235856003 DOID:409
Drug-induced hepatitis contraindication 235876009
Rhabdomyolysis contraindication 240131006
Anemia contraindication 271737000 DOID:2355
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Peripheral nerve disease contraindication 302226006
Pseudomembranous enterocolitis contraindication 397683000
Myocardial ischemia contraindication 414795007 DOID:3393
Traumatic rupture of tendon contraindication 415749005
Congenital long QT syndrome contraindication 442917000
Severe Cerebral Arteriosclerosis contraindication
Tremors contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.12 acidic
pKa2 8.29 Basic
pKa3 1.12 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Multidrug and toxin extrusion protein 1 Transporter IC50 4.75 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 3.04 WOMBAT-PK
CAAX prenyl protease 2 Enzyme AC50 4.39 CHEMBL
DNA gyrase Enzyme INHIBITOR CHEMBL CHEMBL
DNA topoisomerase 4 Enzyme INHIBITOR CHEMBL CHEMBL
DNA gyrase subunit A Enzyme IC50 4.28 CHEMBL

External reference:

IDSource
C3661457 UMLSCUI
D00588 KEGG_DRUG
6GNT3Y5LMF UNII
138199-71-0 SECONDARY_CAS_RN
182289 MMSL
96087006 SNOMEDCT_US
006299 NDDF
82122 RXNORM
387552007 SNOMEDCT_US
4021005 VANDF
4972 MMSL
d04109 MMSL
CHEMBL33 ChEMBL_ID
6708 INN_ID
LFX PDB_CHEM_ID
DB01137 DRUGBANK_ID
CHEBI:63598 CHEBI
D064704 MESH_DESCRIPTOR_UI
149096 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0121-0872 SOLUTION 25 mg ORAL ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9315 INJECTION, SOLUTION 250 mg INTRAVENOUS ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9316 INJECTION, SOLUTION 500 mg INTRAVENOUS ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9317 INJECTION, SOLUTION 750 mg INTRAVENOUS ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9720 INJECTION, SOLUTION 750 mg INTRAVENOUS ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9721 INJECTION, SOLUTION 500 mg INTRAVENOUS ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9722 INJECTION, SOLUTION 250 mg INTRAVENOUS ANDA 19 sections
LEVOFLOXACIN HUMAN PRESCRIPTION DRUG LABEL 1 0409-0528 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 20 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0527-1948 SOLUTION 25 mg ORAL ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0781-5790 TABLET, FILM COATED 250 mg ORAL ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0781-5791 TABLET, FILM COATED 500 mg ORAL ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0781-5792 TABLET, FILM COATED 750 mg ORAL ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6351 TABLET, FILM COATED 250 mg ORAL ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6352 TABLET, FILM COATED 500 mg ORAL ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6353 TABLET, FILM COATED 750 mg ORAL ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-143 TABLET, FILM COATED 500 mg ORAL ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-245 TABLET, FILM COATED 750 mg ORAL ANDA 21 sections
levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-451 TABLET, FILM COATED 500 mg ORAL ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-558 TABLET, FILM COATED 500 mg ORAL ANDA 21 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-624 TABLET, FILM COATED 500 mg ORAL ANDA 21 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-906 TABLET, FILM COATED 750 mg ORAL ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 12634-674 TABLET, FILM COATED 750 mg ORAL ANDA 20 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 12634-675 TABLET, FILM COATED 500 mg ORAL ANDA 19 sections
LEVOFLOXACIN HUMAN PRESCRIPTION DRUG LABEL 1 16571-150 SOLUTION/ DROPS 5 mg TOPICAL ANDA 10 sections
LEVOFLOXACIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-992 TABLET, FILM COATED 500 mg ORAL ANDA 20 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 17478-106 SOLUTION 5 mg OPHTHALMIC ANDA 14 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 17478-107 INJECTION 25 mg INTRAVENOUS ANDA 20 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 17856-0286 SOLUTION 25 mg ORAL ANDA 19 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 21695-024 TABLET, FILM COATED 250 mg ORAL ANDA 20 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 21695-027 TABLET, FILM COATED 500 mg ORAL ANDA 20 sections