levofloxacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 1569 100986-85-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levofloxacin anhydrous
  • levofloxacin hydrate
  • levaquin
  • oftaquix
  • quixin
  • (S)-Ofloxacin
  • levofloxacin
The L-isomer of Ofloxacin.
  • Molecular weight: 361.37
  • Formula: C18H20FN3O4
  • CLOGP: -0.26
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 73.32
  • ALOGS: -2.40
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.24 g Inhal.solution
0.50 g O
0.50 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 74 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 29.65 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.90 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.75 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8.80 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.509 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.080 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 9.705 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 1.690 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 87.320 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 86.750 % High 1
herg hERG pIC50 4.280 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 0.989 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.141 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 86.620 % High 1
kinase-safety-class GRK2,PDK1,PDK2,PDK4 4
kinase-selectivity-class ACVR2B,AXL,BRAF,CAMK2D,CDK9,DYRK1B,EIF2AK3,GRK2,MAPK7,PDK4,PRKDC,SIK2,STK33,TEK,TTK 15
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 2.455 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 9.268 High 1
mh-clint Mouse hepatocyte intrinsic clearance 2.218 High 1
mppb Mouse plasma protein binding (% unbound) 83.930 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 16.866 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 87.320 % High 1
rat-kpuu-brain Rat brain Kpuu 0.068 % High 1
rh-clint Rat hepatocyte intrinsic clearance 0.953 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 90.560 % High 1
rppb Rat plasma protein binding (% unbound) 72.500 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 885.116 uM High 1

Approvals:

DateAgencyCompanyOrphan
Dec. 20, 1996 FDA JANSSEN PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1169.98 10.02 2042 107428 461567 90057410
Tendon pain 709.77 10.02 238 109232 3510 90515467
Creatinine renal clearance decreased 672.89 10.02 366 109104 18533 90500444
Sedation complication 653.32 10.02 346 109124 16598 90502379
Blood calcium decreased 550.08 10.02 381 109089 29801 90489176
Orthostatic hypotension 537.68 10.02 428 109042 41399 90477578
Drug reaction with eosinophilia and systemic symptoms 535.75 10.02 431 109039 42327 90476650
Tendonitis 484.24 10.02 309 109161 21063 90497914
Sedation 459.09 10.02 415 109055 47756 90471221
Cognitive disorder 454.41 10.02 487 108983 68920 90450057
Tendon disorder 433.74 10.02 195 109275 6505 90512472
Tendon rupture 432.30 10.02 215 109255 9028 90509949
Febrile neutropenia 416.36 10.02 712 108758 157637 90361340
Depressed level of consciousness 394.76 10.02 463 109007 72321 90446656
Pemphigus 345.11 10.02 11 109459 326853 90192124
Hand deformity 332.19 10.02 5 109465 296357 90222620
Glossodynia 328.79 10.02 14 109456 321765 90197212
Arthropathy 327.11 10.02 32 109438 366210 90152767
Balance disorder 321.45 10.02 485 108985 96595 90422382
Systemic lupus erythematosus 290.53 10.02 45 109425 361851 90157126
Anti-cyclic citrullinated peptide antibody positive 269.29 10.02 3 109467 236430 90282547
Maternal exposure during pregnancy 254.74 10.02 61 109409 360002 90158975
Synovitis 234.95 10.02 55 109415 329697 90189280
Pericarditis 229.96 10.02 28 109442 270123 90248854
Duodenal ulcer perforation 228.08 10.02 9 109461 221279 90297698
International normalised ratio fluctuation 219.42 10.02 96 109374 2997 90515980
Helicobacter infection 218.68 10.02 14 109456 226836 90292141
Wound 216.90 10.02 50 109420 302930 90216047
Folliculitis 215.16 10.02 7 109463 204346 90314631
Constipation 209.43 10.02 779 108691 279616 90239361
Impaired healing 195.13 10.02 26 109444 234173 90284804
Drug interaction 194.03 10.02 753 108717 275700 90243277
Rheumatoid factor positive 191.82 10.02 3 109467 171647 90347330
Psoriatic arthropathy 191.07 10.02 25 109445 228310 90290667
Bloody discharge 186.15 10.02 78 109392 2185 90516792
Irritable bowel syndrome 185.42 10.02 18 109452 207430 90311547
Alopecia 179.67 10.02 200 109270 494871 90024106
Muscle injury 179.30 10.02 8 109462 176646 90342331
Discomfort 174.38 10.02 57 109413 274278 90244699
Joint swelling 170.17 10.02 215 109255 503085 90015892
Hypotension 169.56 10.02 810 108660 324587 90194390
Blood cholesterol increased 157.72 10.02 30 109440 207982 90310995
Contrast media allergy 157.01 10.02 76 109394 3005 90515972
Neutropenia 154.00 10.02 608 108862 224296 90294681
Neuropathy peripheral 150.33 10.02 434 109036 136536 90382441
Pneumonia 150.07 10.02 1297 108173 636762 89882215
Weight increased 147.05 10.02 173 109297 417754 90101223
Toxic epidermal necrolysis 145.70 10.02 188 109282 32340 90486637
Atelectasis 145.28 10.02 163 109307 24246 90494731
Type 2 diabetes mellitus 140.59 10.02 36 109434 203208 90315769
Electrocardiogram QT prolonged 140.36 10.02 286 109184 72170 90446807
Computerised tomogram thorax abnormal 139.09 10.02 62 109408 2025 90516952
Sleep disorder due to general medical condition, insomnia type 136.91 10.02 4 109466 128690 90390287
Loss of employment 135.30 10.02 68 109402 2919 90516058
Rash maculo-papular 134.68 10.02 204 109266 40729 90478248
Thrombocytopenia 134.68 10.02 554 108916 208171 90310806
Lyme disease 131.09 10.02 75 109395 4187 90514790
Pyrexia 129.79 10.02 1292 108178 659193 89859784
Infusion related reaction 129.72 10.02 189 109281 416591 90102386
Fibromyalgia 129.05 10.02 44 109426 206225 90312752
Dysbiosis 127.83 10.02 55 109415 1647 90517330
Respiratory failure 124.92 10.02 370 109100 118048 90400929
Swelling 122.77 10.02 198 109272 418860 90100117
Anaemia 122.52 10.02 787 108683 352015 90166962
Ill-defined disorder 121.79 10.02 36 109434 184855 90334122
Pseudomembranous colitis 121.47 10.02 69 109401 3799 90515178
Clostridium difficile colitis 117.50 10.02 153 109317 26553 90492424
Lower respiratory tract infection 116.52 10.02 80 109390 250579 90268398
Musculoskeletal stiffness 113.94 10.02 114 109356 296418 90222559
Eosinophilia 112.57 10.02 155 109315 28378 90490599
Drug resistance 112.09 10.02 160 109310 30289 90488688
Completed suicide 107.67 10.02 22 109448 145036 90373941
Abdominal discomfort 106.01 10.02 265 109205 477063 90041914
Neutrophil count decreased 105.34 10.02 253 109217 71279 90447698
Contraindicated product administered 104.74 10.02 140 109330 319999 90198978
Lip dry 104.34 10.02 4 109466 100951 90418026
Peripheral swelling 104.19 10.02 214 109256 412892 90106085
C-reactive protein abnormal 104.08 10.02 15 109455 127414 90391563
Acute generalised exanthematous pustulosis 103.73 10.02 104 109366 13599 90505378
Hypoxia 101.22 10.02 251 109219 72148 90446829
Exposure during pregnancy 100.67 10.02 84 109386 238326 90280651
Nasopharyngitis 100.05 10.02 214 109256 406890 90112087
Computerised tomogram thorax 98.05 10.02 33 109437 492 90518485
Sepsis 95.98 10.02 451 109019 179363 90339614
Osteoarthritis 95.67 10.02 59 109411 195671 90323306
Rheumatoid arthritis 94.72 10.02 184 109286 362430 90156547
Neurotoxicity 94.46 10.02 123 109347 21344 90497633
Hepatic enzyme increased 93.40 10.02 184 109286 360552 90158425
Septic shock 91.64 10.02 266 109204 83894 90435083
Grip strength decreased 91.34 10.02 5 109465 92571 90426406
Therapeutic product effect decreased 91.17 10.02 121 109349 277450 90241527
Hepatic function abnormal 91.16 10.02 184 109286 46104 90472873
Blister 89.13 10.02 106 109364 254892 90264085
Acute kidney injury 89.00 10.02 677 108793 319710 90199267
Pneumonia fungal 86.16 10.02 70 109400 6961 90512016
Creatinine renal clearance increased 85.83 10.02 52 109418 3229 90515748
Torsade de pointes 82.94 10.02 97 109373 15085 90503892
Hypokalaemia 82.14 10.02 345 109125 130771 90388206
Contusion 82.00 10.02 110 109360 251106 90267871
Bronchopulmonary aspergillosis 81.70 10.02 84 109386 11314 90507663
Joint range of motion decreased 81.31 10.02 31 109439 135612 90383365
Sciatica 80.36 10.02 13 109457 101369 90417608
Hypercholesterolaemia 79.83 10.02 13 109457 100879 90418098
Pathogen resistance 79.41 10.02 71 109399 8044 90510933
Platelet count decreased 79.36 10.02 352 109118 136617 90382360
Intentional overdose 79.11 10.02 10 109460 93824 90425153
Cholestasis 78.39 10.02 150 109320 36149 90482828
Liver injury 77.18 10.02 56 109414 170511 90348466
Tongue oedema 76.95 10.02 59 109411 5395 90513582
Myoclonus 76.93 10.02 105 109365 19063 90499914
Crystal nephropathy 76.09 10.02 34 109436 1117 90517860
Injection site reaction 74.82 10.02 11 109459 92069 90426908
Migraine 74.48 10.02 72 109398 190320 90328657
Product use issue 74.09 10.02 182 109288 329737 90189240
Cough 73.81 10.02 725 108745 368237 90150740
Peripheral venous disease 73.09 10.02 8 109462 83913 90435064
Bursitis 72.64 10.02 34 109436 131620 90387357
Disseminated mucormycosis 72.00 10.02 28 109442 643 90518334
Lip oedema 71.70 10.02 53 109417 4586 90514391
Hypocoagulable state 71.25 10.02 36 109434 1563 90517414
Pancytopenia 71.13 10.02 311 109159 119952 90399025
Intentional product use issue 70.74 10.02 95 109375 216797 90302180
Obesity 70.46 10.02 20 109450 105487 90413490
Haemophagocytic lymphohistiocytosis 70.24 10.02 90 109380 15369 90503608
Injury 70.06 10.02 81 109389 197268 90321709
Lower limb fracture 69.44 10.02 10 109460 85003 90433974
Trimethylaminuria 69.38 10.02 20 109450 172 90518805
Inflammation 69.32 10.02 68 109402 178524 90340453
General physical health deterioration 68.46 10.02 211 109259 354904 90164073
Vanishing bile duct syndrome 67.38 10.02 33 109437 1339 90517638
Road traffic accident 67.22 10.02 23 109447 107603 90411374
Obliterative bronchiolitis 66.32 10.02 41 109429 2640 90516337
Cytokine release syndrome 65.91 10.02 120 109350 27853 90491124
Multiple organ dysfunction syndrome 65.01 10.02 206 109264 68130 90450847
Tendon discomfort 64.34 10.02 21 109449 283 90518694
Dry mouth 63.78 10.02 77 109393 183982 90334995
Status epilepticus 63.41 10.02 95 109375 18779 90500198
Hyperbilirubinaemia 63.11 10.02 81 109389 13855 90505122
Knee arthroplasty 63.01 10.02 12 109458 83170 90435807
Skin reaction 60.36 10.02 92 109378 18461 90500516
Hip arthroplasty 59.89 10.02 10 109460 76198 90442779
Respiratory muscle weakness 59.84 10.02 18 109452 182 90518795
Drug eruption 59.57 10.02 132 109338 35275 90483702
Wound infection 59.44 10.02 27 109443 106375 90412602
Stevens-Johnson syndrome 59.31 10.02 118 109352 29258 90489719
Musculoskeletal injury 58.79 10.02 17 109453 148 90518829
Symmetrical drug-related intertriginous and flexural exanthema 58.65 10.02 27 109443 952 90518025
Factor XIII deficiency 57.75 10.02 15 109455 83 90518894
Vascular purpura 57.28 10.02 32 109438 1706 90517271
Arthritis 56.91 10.02 71 109399 167244 90351733
Injection site pain 55.71 10.02 77 109393 173622 90345355
Hypoglycaemia 55.34 10.02 198 109272 69650 90449327
Toxic skin eruption 55.29 10.02 81 109389 15693 90503284
Renal function test abnormal 55.21 10.02 55 109415 7136 90511841
Candida infection 55.09 10.02 125 109345 33932 90485045
Prescribed overdose 54.18 10.02 25 109445 97600 90421377
Product quality issue 53.03 10.02 15 109455 79310 90439667
Staphylococcal infection 52.62 10.02 153 109317 48286 90470691
Megacolon 52.60 10.02 33 109437 2181 90516796
Pneumonitis 52.37 10.02 144 109326 44026 90474951
Blepharospasm 51.72 10.02 4 109466 55441 90463536
Myalgia 51.36 10.02 375 109095 174750 90344227
Face oedema 51.14 10.02 97 109373 23221 90495756
Acquired macroglossia 49.55 10.02 16 109454 208 90518769
Pregnancy 49.07 10.02 8 109462 62039 90456938
Streptococcal sepsis 48.88 10.02 38 109432 3546 90515431
Mucormycosis 48.85 10.02 39 109431 3782 90515195
Prescribed underdose 48.66 10.02 15 109455 75004 90443973
Agranulocytosis 48.54 10.02 121 109349 34881 90484096
Eosinophilic pneumonia 48.15 10.02 34 109436 2739 90516238
Acute myeloid leukaemia 47.94 10.02 88 109382 20552 90498425
Hepatic cytolysis 47.29 10.02 111 109359 30805 90488172
Dyspnoea 47.05 10.02 1394 108076 879561 89639416
Pulmonary fibrosis 46.44 10.02 37 109433 107466 90411511
Erythema multiforme 46.02 10.02 65 109405 12181 90506796
White blood cell count decreased 45.70 10.02 352 109118 166757 90352220
Stomatitis 45.61 10.02 174 109296 274524 90244453
Multiple drug therapy 45.51 10.02 49 109421 6960 90512017
International normalised ratio increased 44.42 10.02 142 109328 47174 90471803
Sleep disorder 43.83 10.02 110 109360 197920 90321057
Hepatic steatosis 43.35 10.02 120 109350 36825 90482152
Respiratory syncytial virus infection 42.95 10.02 58 109412 10422 90508555
Long QT syndrome 42.86 10.02 37 109433 4000 90514977
Nasal mucosal disorder 42.42 10.02 27 109443 1830 90517147
Night sweats 42.38 10.02 56 109414 128710 90390267
Suicide attempt 42.32 10.02 19 109451 75380 90443597
Iron deficiency 42.17 10.02 55 109415 9557 90509420
Choroidal effusion 41.83 10.02 20 109450 769 90518208
Exostosis 41.69 10.02 7 109463 53127 90465850
Lupus-like syndrome 41.67 10.02 5 109465 48841 90470136
Cryopyrin associated periodic syndrome 41.50 10.02 18 109452 550 90518427
Hypoglycaemic coma 41.43 10.02 32 109438 2958 90516019
Systemic inflammatory response syndrome 41.34 10.02 45 109425 6471 90512506
Headache 41.29 10.02 764 108706 861982 89656995
Toxicity to various agents 41.27 10.02 530 108940 287316 90231661
Therapeutic response decreased 41.18 10.02 29 109441 89700 90429277
Clostridium difficile infection 40.84 10.02 116 109354 36129 90482848
Nail bed inflammation 40.68 10.02 26 109444 1775 90517202
Mixed liver injury 40.47 10.02 48 109422 7575 90511402
Immune reconstitution inflammatory syndrome associated tuberculosis 40.24 10.02 17 109453 486 90518491
Tendon injury 39.99 10.02 28 109442 2225 90516752
Ectropion 39.74 10.02 14 109456 241 90518736
Collagen disorder 39.53 10.02 14 109456 245 90518732
Coeliac disease 39.49 10.02 4 109466 44606 90474371
Vaccination complication 39.05 10.02 21 109449 1038 90517939
Rash morbilliform 38.92 10.02 35 109435 3994 90514983
Onychomadesis 38.53 10.02 5 109465 45993 90472984
Vascular device infection 38.50 10.02 59 109411 11893 90507084
Hypomagnesaemia 38.26 10.02 112 109358 35476 90483501
Plasma cell myeloma 37.84 10.02 122 109348 40706 90478271
Drug ineffective 37.74 10.02 1332 108138 1382966 89136011
Autoimmune disorder 37.66 10.02 23 109447 76721 90442256
Factor V inhibition 36.95 10.02 12 109458 159 90518818
Pneumonia bacterial 36.87 10.02 60 109410 12730 90506247
Erythema 36.70 10.02 431 109039 228815 90290162
Adverse event 36.70 10.02 53 109417 117365 90401612
Condition aggravated 36.62 10.02 503 108967 595042 89923935
Aspartate aminotransferase increased 36.48 10.02 231 109239 102706 90416271
Graft versus host disease 36.35 10.02 47 109423 8097 90510880
Hallucination 36.30 10.02 167 109303 65792 90453185
Chronic fatigue syndrome 36.18 10.02 23 109447 1556 90517421
Enterococcal infection 36.03 10.02 52 109418 9939 90509038
X-ray abnormal 35.60 10.02 6 109464 45418 90473559
Hypoaesthesia 35.45 10.02 228 109242 313982 90204995
Cystic fibrosis pancreatic 35.41 10.02 9 109461 45 90518932
Pseudomonal sepsis 35.07 10.02 34 109436 4268 90514709
Bronchitis 34.77 10.02 309 109161 152618 90366359
Type I hypersensitivity 34.17 10.02 33 109437 4122 90514855
Gastrooesophageal reflux disease 34.07 10.02 96 109374 166241 90352736
Mucosal inflammation 34.04 10.02 149 109321 57476 90461501
Dyspepsia 33.87 10.02 124 109346 198036 90320941
Conjunctival hyperaemia 33.56 10.02 29 109441 3140 90515837
Foot deformity 33.53 10.02 15 109455 59636 90459341
Immune effector cell-associated neurotoxicity syndrome 33.43 10.02 38 109432 5730 90513247
Blood bilirubin increased 33.38 10.02 122 109348 43348 90475629
Sense of oppression 32.88 10.02 19 109451 1081 90517896
Osteoporosis 32.77 10.02 41 109429 96490 90422487
Stenotrophomonas infection 32.73 10.02 26 109444 2503 90516474
Back injury 32.71 10.02 8 109462 46614 90472363
Lacunar stroke 32.35 10.02 12 109458 241 90518736
Gastritis fungal 32.32 10.02 11 109459 170 90518807
Muscle atrophy 32.18 10.02 45 109425 8356 90510621
Fungaemia 32.16 10.02 29 109441 3321 90515656
Septic embolus 31.89 10.02 18 109452 979 90517998
Keratopathy 31.72 10.02 16 109454 692 90518285
Complex regional pain syndrome 31.59 10.02 26 109444 2633 90516344
Aspergillus infection 31.50 10.02 51 109419 10772 90508205
Blood lactate dehydrogenase increased 31.19 10.02 85 109385 25847 90493130
Laryngeal oedema 31.17 10.02 40 109430 6841 90512136
Lupus vulgaris 31.10 10.02 8 109462 45051 90473926
Supraventricular tachycardia 31.05 10.02 64 109406 16272 90502705
Dysentery 30.52 10.02 18 109452 1064 90517913
Intentional product misuse 30.48 10.02 38 109432 89566 90429411
Muscle tension dysphonia 30.40 10.02 12 109458 287 90518690
Gait inability 30.38 10.02 84 109386 146372 90372605
Haematoma 30.33 10.02 110 109360 38938 90480039
Fall 30.30 10.02 779 108691 481031 90037946
Arteritis infective 30.19 10.02 9 109461 88 90518889
Glaucoma 30.10 10.02 73 109397 20682 90498295
Joint stiffness 29.94 10.02 30 109440 78012 90440965
Meningitis tuberculous 29.86 10.02 15 109455 643 90518334
Underdose 29.71 10.02 14 109456 54003 90464974
Leukopenia 29.71 10.02 216 109254 100494 90418483
Confabulation 29.61 10.02 12 109458 308 90518669
Purpura fulminans 29.49 10.02 9 109461 96 90518881
Upper respiratory tract inflammation 29.41 10.02 25 109445 2647 90516330
Disseminated intravascular coagulation 29.38 10.02 74 109396 21464 90497513
Injection site erythema 29.29 10.02 46 109424 98456 90420521
Injection site swelling 29.27 10.02 18 109452 59821 90459156
Bone erosion 28.77 10.02 14 109456 53007 90465970
Nail disorder 28.57 10.02 18 109452 59049 90459928
Acute myeloid leukaemia recurrent 28.47 10.02 22 109448 2035 90516942
Angioedema 28.43 10.02 154 109316 64722 90454255
Japanese spotted fever 28.42 10.02 7 109463 30 90518947
Weber tuning fork test abnormal 28.38 10.02 9 109461 110 90518867
Chronic kidney disease 28.30 10.02 128 109342 50063 90468914
Tumour associated fever 28.30 10.02 13 109457 456 90518521
Myasthenia gravis crisis 28.19 10.02 17 109453 1047 90517930
Incorrect route of product administration 28.03 10.02 13 109457 50613 90468364
Therapy non-responder 27.92 10.02 79 109391 136625 90382352
Paraspinal abscess 27.83 10.02 11 109459 264 90518713
Liver function test increased 27.82 10.02 37 109433 84818 90434159
Macular degeneration 27.67 10.02 6 109464 37964 90481013
Secretion discharge 27.57 10.02 60 109410 15836 90503141
Tubulointerstitial nephritis 27.47 10.02 80 109390 25263 90493714
Muscle contractions involuntary 27.43 10.02 25 109445 2903 90516074
Umbilical erythema 27.43 10.02 8 109462 72 90518905
Encephalopathy 27.36 10.02 120 109350 46324 90472653
Enterocolitis 27.29 10.02 47 109423 10443 90508534
Influenza B virus test positive 27.19 10.02 11 109459 281 90518696
Acute febrile neutrophilic dermatosis 27.00 10.02 27 109443 3518 90515459
Colitis ulcerative 26.97 10.02 20 109450 60246 90458731
Respiratory tract infection fungal 26.88 10.02 13 109457 513 90518464
Pleural effusion 26.86 10.02 229 109241 111762 90407215
Depression 26.81 10.02 233 109237 300368 90218609
Acute graft versus host disease 26.70 10.02 33 109437 5435 90513542
Infective pulmonary exacerbation of cystic fibrosis 26.67 10.02 46 109424 10233 90508744
Ventricular fibrillation 26.66 10.02 55 109415 13989 90504988
Band sensation 26.66 10.02 17 109453 1156 90517821
Amnesia 26.63 10.02 57 109413 108448 90410529
Injection site bruising 26.62 10.02 15 109455 52292 90466685
Early retirement 26.54 10.02 6 109464 16 90518961
Palatal oedema 26.54 10.02 14 109456 665 90518312
Treatment failure 26.48 10.02 237 109233 303691 90215286
Bacterial infection 26.38 10.02 75 109395 23369 90495608
Altered state of consciousness 26.36 10.02 91 109379 31441 90487536
Foreign body aspiration 26.15 10.02 10 109460 219 90518758
Brain oedema 26.13 10.02 62 109408 17323 90501654
Splenic vein thrombosis 26.12 10.02 12 109458 421 90518556
Hepatitis cholestatic 25.82 10.02 41 109429 8520 90510457
Wrong technique in product usage process 25.79 10.02 29 109441 71542 90447435
Drug tolerance decreased 25.73 10.02 4 109466 32126 90486851
Pulmonary renal syndrome 25.57 10.02 13 109457 572 90518405
Mobility decreased 25.44 10.02 435 109035 250299 90268678
Hyperpyrexia 25.31 10.02 30 109440 4731 90514246
Walking aid user 25.09 10.02 6 109464 35500 90483477
Basal cell carcinoma 24.90 10.02 5 109465 33384 90485593
Premature delivery 24.69 10.02 8 109462 38754 90480223
Rhinovirus infection 24.43 10.02 33 109437 5930 90513047
Clostridial infection 24.30 10.02 29 109441 4607 90514370
Nervous system disorder 24.22 10.02 69 109401 21524 90497453
Frequent bowel movements 24.08 10.02 20 109450 56915 90462062
Rhabdomyolysis 24.06 10.02 124 109346 51132 90467845
Weight decreased 23.99 10.02 319 109151 379591 90139386
Colitis microscopic 23.95 10.02 46 109424 11113 90507864
Generalised onset non-motor seizure 23.95 10.02 6 109464 28 90518949
Memory impairment 23.86 10.02 140 109330 197104 90321873
Bacteraemia 23.80 10.02 70 109400 22230 90496747
Interstitial lung disease 23.77 10.02 166 109304 76239 90442738
Paradoxical drug reaction 23.76 10.02 32 109438 5734 90513243
Productive cough 23.72 10.02 167 109303 76896 90442081
Purpura 23.63 10.02 54 109416 14724 90504253
Recall phenomenon 23.62 10.02 14 109456 835 90518142
Enterocolitis bacterial 23.60 10.02 10 109460 288 90518689
Adverse drug reaction 23.42 10.02 68 109402 116633 90402344
Graft versus host disease in skin 23.39 10.02 26 109444 3827 90515150
Acute respiratory distress syndrome 23.30 10.02 82 109388 28604 90490373
Wheezing 23.29 10.02 180 109290 237900 90281077
Optic neuropathy 23.27 10.02 22 109448 2676 90516301
Epidermolysis 23.22 10.02 13 109457 696 90518281
Pneumocystis jirovecii pneumonia 23.21 10.02 68 109402 21548 90497429
Renal necrosis 23.16 10.02 7 109463 72 90518905
Cytomegalovirus test positive 23.13 10.02 25 109445 3566 90515411
Inappropriate schedule of product administration 22.95 10.02 98 109372 149835 90369142
Plantar fasciitis 22.83 10.02 27 109443 4247 90514730
Therapy naive 22.83 10.02 6 109464 35 90518942
Glomerulonephritis rapidly progressive 22.82 10.02 16 109454 1274 90517703
Generalised tonic-clonic seizure 22.75 10.02 93 109377 34810 90484167
Anti-neutrophil cytoplasmic antibody positive vasculitis 22.63 10.02 26 109444 3967 90515010
Respiratory tract infection 22.45 10.02 135 109335 58943 90460034
Trichoglossia 22.33 10.02 11 109459 452 90518525
Pseudomonas infection 22.33 10.02 53 109417 14812 90504165
Connective tissue disorder 22.32 10.02 18 109452 1771 90517206
Graft versus host disease in gastrointestinal tract 22.26 10.02 27 109443 4361 90514616
Nocardiosis 22.25 10.02 21 109449 2549 90516428
Bronchitis chronic 22.16 10.02 28 109442 4715 90514262
Excessive eye blinking 21.94 10.02 16 109454 1356 90517621
Accidental exposure to product 21.78 10.02 12 109458 42354 90476623
Sputum discoloured 21.75 10.02 64 109406 20327 90498650
Metastatic malignant melanoma 21.67 10.02 17 109453 1607 90517370
Blood alkaline phosphatase increased 21.66 10.02 115 109355 47964 90471013
Functional residual capacity increased 21.61 10.02 7 109463 92 90518885
Bronchial wall thickening 21.56 10.02 19 109451 2112 90516865
Immune-mediated lung disease 21.54 10.02 18 109452 1862 90517115
Jaundice 21.48 10.02 87 109383 32430 90486547
Hyperuricaemia 21.41 10.02 33 109437 6686 90512291
Petechiae 21.39 10.02 54 109416 15687 90503290
Hepatic cirrhosis 21.33 10.02 27 109443 63226 90455751
Sinusitis 21.32 10.02 289 109181 342799 90176178
Nausea 21.21 10.02 1585 107885 1108731 89410246
Tonsillitis bacterial 21.15 10.02 8 109462 170 90518807
Bronchial obstruction 21.08 10.02 17 109453 1672 90517305
Peripheral sensory neuropathy 20.93 10.02 39 109431 9211 90509766
Long QT syndrome congenital 20.52 10.02 7 109463 109 90518868
Pneumothorax 20.29 10.02 60 109410 19107 90499870
Respiratory distress 20.25 10.02 97 109373 38849 90480128
Boutonneuse fever 20.11 10.02 4 109466 4 90518973
Disseminated strongyloidiasis 20.01 10.02 6 109464 60 90518917
Renal failure 19.94 10.02 244 109226 130763 90388214
Fat necrosis 19.88 10.02 12 109458 740 90518237
Product name confusion 19.69 10.02 7 109463 124 90518853
Acute sinusitis 19.66 10.02 25 109445 4236 90514741
Cerebral artery thrombosis 19.58 10.02 10 109460 444 90518533
Foetal exposure during pregnancy 19.57 10.02 14 109456 42961 90476016
Acute respiratory failure 19.57 10.02 103 109367 42815 90476162
Urinary tract infection enterococcal 19.43 10.02 21 109449 2995 90515982
Chordae tendinae rupture 19.35 10.02 5 109465 27 90518950
Endophthalmitis 19.31 10.02 26 109444 4659 90514318
Skin injury 19.18 10.02 18 109452 2170 90516807
Taste disorder 19.01 10.02 28 109442 61518 90457459
Leukocytosis 18.97 10.02 81 109389 30909 90488068
Postural tremor 18.94 10.02 10 109460 476 90518501
Hallucination, visual 18.74 10.02 66 109404 23026 90495951
Alanine aminotransferase increased 18.70 10.02 222 109248 118116 90400861
Kounis syndrome 18.63 10.02 19 109451 2534 90516443
Ultrasound foetal abnormal 18.63 10.02 7 109463 146 90518831
Cross sensitivity reaction 18.59 10.02 20 109450 2837 90516140
Dysphonia 18.43 10.02 135 109335 62949 90456028
Oedema 18.41 10.02 154 109316 200141 90318836
Staphylococcal scalded skin syndrome 18.41 10.02 7 109463 151 90518826
Pulmonary infarction 18.39 10.02 20 109450 2872 90516105
Factor XIII Inhibition 18.37 10.02 5 109465 34 90518943
Acquired haemophilia 18.31 10.02 13 109457 1056 90517921
Systemic mycosis 18.26 10.02 15 109455 1515 90517462
Fusarium infection 18.17 10.02 13 109457 1069 90517908
Muscle spasticity 18.16 10.02 10 109460 35312 90483665
Stress 18.16 10.02 45 109425 81350 90437627
Blast cell count increased 18.14 10.02 10 109460 519 90518458
Hydrocephalus 18.13 10.02 29 109441 6065 90512912
Ear pain 18.07 10.02 26 109444 57676 90461301
Bone marrow failure 18.04 10.02 82 109388 32139 90486838
Cardiac failure 18.01 10.02 207 109263 109289 90409688
Cystic fibrosis 17.99 10.02 23 109447 3918 90515059
Pulmonary embolism 17.94 10.02 239 109231 130581 90388396
Loss of personal independence in daily activities 17.88 10.02 94 109376 136011 90382966
Upper respiratory tract infection 17.83 10.02 235 109235 128083 90390894
Laryngitis 17.81 10.02 21 109449 50732 90468245
Confusional state 17.78 10.02 344 109126 385861 90133116
Cerebrovascular accident 17.55 10.02 83 109387 123450 90395527
Ulcer haemorrhage 17.55 10.02 5 109465 26316 90492661
Acute graft versus host disease in skin 17.51 10.02 25 109445 4731 90514246
Corneal erosion 17.43 10.02 9 109461 409 90518568
Dysphemia 17.41 10.02 20 109450 3050 90515927
Adrenal cortex necrosis 17.35 10.02 4 109466 12 90518965
Haemoptysis 17.33 10.02 83 109387 33237 90485740
Angle closure glaucoma 17.32 10.02 19 109451 2756 90516221
Thyroid disorder 17.26 10.02 54 109416 17731 90501246
Polyneuropathy 17.21 10.02 57 109413 19284 90499693
Herpes simplex viraemia 17.19 10.02 9 109461 421 90518556
Restlessness 17.17 10.02 87 109383 35633 90483344
Suicidal ideation 17.14 10.02 40 109430 73815 90445162
Hepatosplenic abscess 17.11 10.02 4 109466 13 90518964
Blood pressure increased 17.07 10.02 154 109316 197063 90321914
Device related infection 17.04 10.02 69 109401 25717 90493260
Lymphadenopathy 17.01 10.02 104 109366 45671 90473306
Tongue exfoliation 16.99 10.02 6 109464 104 90518873
Circumoral oedema 16.99 10.02 8 109462 297 90518680
Anaphylactic reaction 16.97 10.02 171 109299 87353 90431624
Cardiac failure congestive 16.88 10.02 188 109282 98506 90420471
Immunisation reaction 16.72 10.02 11 109459 789 90518188
Fixed eruption 16.66 10.02 15 109455 1715 90517262
Chorioretinal disorder 16.63 10.02 6 109464 111 90518866
Acinetobacter infection 16.61 10.02 16 109454 1992 90516985
Gamma-glutamyltransferase increased 16.57 10.02 90 109380 37862 90481115
Pneumococcal infection 16.55 10.02 13 109457 1232 90517745
Fatigue 16.54 10.02 1186 108284 1152837 89366140
Paranasal sinus inflammation 16.39 10.02 10 109460 629 90518348
Blood creatinine increased 16.38 10.02 191 109279 101195 90417782
Illusion 16.37 10.02 13 109457 1251 90517726
Oral pruritus 16.36 10.02 19 109451 2932 90516045
Joint dislocation 16.13 10.02 18 109452 44564 90474413
Muscle tightness 16.11 10.02 44 109426 13395 90505582
Oliguria 16.09 10.02 38 109432 10586 90508391
Therapeutic response shortened 15.91 10.02 4 109466 22875 90496102
Lymphocyte count decreased 15.90 10.02 84 109386 34966 90484011
Hepatitis toxic 15.85 10.02 21 109449 3704 90515273
Spinal cord haematoma 15.84 10.02 7 109463 224 90518753
Incorrect dose administered 15.83 10.02 46 109424 78884 90440093
Portal fibrosis 15.78 10.02 8 109462 350 90518627
Enteritis infectious 15.77 10.02 17 109453 2418 90516559
Polyglandular disorder 15.75 10.02 7 109463 227 90518750
Subdural haematoma 15.66 10.02 50 109420 16595 90502382
SJS-TEN overlap 15.66 10.02 12 109458 1096 90517881
Disorientation 15.62 10.02 99 109371 44015 90474962
Sputum purulent 15.60 10.02 13 109457 1339 90517638
Varicose vein 15.48 10.02 30 109440 7297 90511680
Sudden death 15.43 10.02 38 109432 10871 90508106
Myoclonic dystonia 15.42 10.02 4 109466 22 90518955
Bacterial sepsis 15.32 10.02 24 109446 4931 90514046
Pseudoaldosteronism 15.26 10.02 6 109464 142 90518835
Red blood cell sedimentation rate increased 15.24 10.02 50 109420 82545 90436432
Quadriplegia 15.20 10.02 16 109454 2215 90516762
Escherichia infection 15.19 10.02 48 109422 15847 90503130
Cytopenia 15.15 10.02 51 109419 17398 90501579
Sensory disturbance 15.15 10.02 47 109423 15366 90503611
Blood pressure fluctuation 15.09 10.02 25 109445 52388 90466589
Antibiotic associated colitis 15.08 10.02 3 109467 3 90518974
Lymphomatoid papulosis 15.07 10.02 6 109464 147 90518830
Prurigo 15.06 10.02 11 109459 934 90518043
Osteonecrosis of jaw 15.03 10.02 15 109455 39088 90479889
Septic pulmonary embolism 14.99 10.02 6 109464 149 90518828
Sensory processing disorder 14.99 10.02 4 109466 25 90518952
Drug-induced liver injury 14.97 10.02 171 109299 90147 90428830
Food allergy 14.97 10.02 6 109464 25472 90493505
Chest pain 14.93 10.02 284 109186 319361 90199616
Renal tubular necrosis 14.88 10.02 45 109425 14510 90504467
Pyelonephritis 14.85 10.02 58 109412 21258 90497719
Corynebacterium infection 14.83 10.02 11 109459 957 90518020
Lung disorder 14.80 10.02 113 109357 149770 90369207
Eyelid cyst 14.73 10.02 6 109464 156 90518821
Platelet count increased 14.73 10.02 57 109413 20802 90498175
Cerebral hypoperfusion 14.72 10.02 8 109462 404 90518573
Gastrointestinal amyloidosis 14.71 10.02 5 109465 77 90518900
Sputum increased 14.68 10.02 18 109452 2939 90516038
Ventricular tachycardia 14.67 10.02 64 109406 24644 90494333
Eye infection fungal 14.63 10.02 6 109464 159 90518818
Cytokine storm 14.61 10.02 9 109461 576 90518401
Gastroenteritis staphylococcal 14.47 10.02 5 109465 81 90518896
Polymerase chain reaction positive 14.42 10.02 6 109464 165 90518812
Mechanical urticaria 14.34 10.02 9 109461 595 90518382
Pancreatitis necrotising 14.34 10.02 16 109454 2365 90516612
Administration site oedema 14.24 10.02 4 109466 31 90518946
Femur fracture 14.20 10.02 21 109449 46061 90472916
Affective disorder 14.19 10.02 30 109440 7763 90511214
Paralysis 14.18 10.02 38 109432 11440 90507537
Geotrichum infection 14.18 10.02 9 109461 607 90518370
Disability 14.15 10.02 17 109453 40728 90478249
Mitochondrial enzyme deficiency 14.13 10.02 4 109466 32 90518945
Hepatitis B 14.13 10.02 22 109448 4497 90514480
Intestinal polyp 14.07 10.02 13 109457 1536 90517441
Forearm fracture 14.06 10.02 9 109461 616 90518361
Product dose omission issue 13.98 10.02 258 109212 291429 90227548
Blastomycosis 13.88 10.02 8 109462 453 90518524
Mental status changes 13.85 10.02 97 109373 44582 90474395
Fluid retention 13.84 10.02 57 109413 88034 90430943
Vitreous opacities 13.73 10.02 8 109462 462 90518515
Paronychia 13.64 10.02 30 109440 7976 90511001
Pulmonary haemorrhage 13.62 10.02 30 109440 7983 90510994
Dermatitis bullous 13.61 10.02 35 109435 10281 90508696
Staphylococcal sepsis 13.60 10.02 33 109437 9350 90509627
Presyncope 13.60 10.02 75 109395 31730 90487247
Hypoxic-ischaemic encephalopathy 13.59 10.02 22 109448 4646 90514331
Cholangitis 13.49 10.02 28 109442 7154 90511823
Pain 13.45 10.02 1029 108441 995312 89523665
Injection site pruritus 13.44 10.02 28 109442 53806 90465171
Gastric cyst 13.41 10.02 5 109465 102 90518875
Odynophagia 13.32 10.02 32 109438 9011 90509966
Nodular rash 13.29 10.02 6 109464 202 90518775
Mitral valve disease 13.28 10.02 16 109454 2566 90516411
Oesophageal candidiasis 13.27 10.02 27 109443 6802 90512175
Bone marrow leukaemic cell infiltration 13.25 10.02 4 109466 41 90518936
Injection site haemorrhage 13.19 10.02 9 109461 28309 90490668
Rheumatoid nodule 13.13 10.02 4 109466 20162 90498815
Cardiovascular disorder 13.13 10.02 41 109429 13451 90505526
Multiple-drug resistance 13.09 10.02 29 109441 7747 90511230
Toxic encephalopathy 13.05 10.02 31 109439 8668 90510309
Immunodeficiency 13.03 10.02 20 109450 43214 90475763
Musculoskeletal pain 13.02 10.02 138 109332 171113 90347864
Perihepatic discomfort 13.01 10.02 3 109467 9 90518968
Transaminases increased 12.88 10.02 83 109387 37109 90481868
Retroperitoneal haematoma 12.84 10.02 18 109452 3350 90515627
Clostridium colitis 12.76 10.02 14 109456 2031 90516946
Immune reconstitution inflammatory syndrome 12.76 10.02 27 109443 6992 90511985
Restrictive pulmonary disease 12.75 10.02 15 109455 2347 90516630
Chest injury 12.74 10.02 14 109456 2034 90516943
Skin lesion 12.71 10.02 83 109387 37282 90481695
Microscopic polyangiitis 12.69 10.02 6 109464 225 90518752
Neck pain 12.68 10.02 83 109387 113880 90405097
Haemodynamic instability 12.67 10.02 37 109433 11702 90507275
Fear of disease 12.66 10.02 12 109458 1464 90517513
Anterior chamber flare 12.65 10.02 5 109465 120 90518857
Hyperamylasaemia 12.63 10.02 8 109462 538 90518439
Conjunctival oedema 12.62 10.02 10 109460 959 90518018
Skin haemorrhage 12.62 10.02 5 109465 21375 90497602
Infective exacerbation of chronic obstructive airways disease 12.60 10.02 12 109458 1474 90517503
Procedural pain 12.59 10.02 13 109457 33347 90485630
Human herpesvirus 6 infection 12.58 10.02 18 109452 3414 90515563
Gastroenteritis 12.55 10.02 69 109401 29160 90489817
Medication error 12.54 10.02 56 109414 84596 90434381
Walking disability 12.53 10.02 12 109458 1483 90517494
Candida endophthalmitis 12.53 10.02 4 109466 50 90518927
Arthralgia 12.48 10.02 792 108678 777730 89741247
Cytomegalovirus viraemia 12.44 10.02 28 109442 7558 90511419
Diabetic ketoacidosis 12.42 10.02 7 109463 24400 90494577
Purpura non-thrombocytopenic 12.39 10.02 5 109465 127 90518850
Pupillary block 12.35 10.02 3 109467 12 90518965
Hepatic cyst infection 12.24 10.02 5 109465 131 90518846
Device malfunction 12.23 10.02 5 109465 20972 90498005
Feeling abnormal 12.22 10.02 136 109334 167099 90351878
Superinfection fungal 12.15 10.02 3 109467 13 90518964
Myoglobin blood increased 12.15 10.02 12 109458 1540 90517437
Haematoma muscle 12.13 10.02 13 109457 1837 90517140
Bone density decreased 12.12 10.02 3 109467 17342 90501635
Bacterial test positive 12.09 10.02 23 109447 5516 90513461
Apallic syndrome 12.09 10.02 9 109461 787 90518190
Psoriasis 12.09 10.02 117 109353 147637 90371340
Lividity 12.05 10.02 7 109463 402 90518575
Hyperinsulinaemic hypoglycaemia 12 10.02 5 109465 138 90518839
Connective tissue inflammation 11.99 10.02 4 109466 58 90518919
Cachexia 11.97 10.02 26 109444 6852 90512125
Vomiting 11.91 10.02 1106 108364 787187 89731790
Strongyloidiasis 11.83 10.02 12 109458 1590 90517387
Haemolytic anaemia 11.80 10.02 36 109434 11661 90507316
Asteatosis 11.80 10.02 4 109466 61 90518916
Differentiation syndrome 11.76 10.02 11 109459 1320 90517657
Blood pressure systolic increased 11.70 10.02 34 109436 58311 90460666
Enterobacter infection 11.67 10.02 15 109455 2568 90516409
Drug dependence 11.56 10.02 11 109459 29316 90489661
Agitation 11.55 10.02 128 109342 66970 90452007
Linear IgA disease 11.55 10.02 14 109456 2260 90516717
Human herpesvirus 6 infection reactivation 11.54 10.02 8 109462 626 90518351
Rhonchi 11.48 10.02 16 109454 2962 90516015
Neutrophilic dermatosis 11.47 10.02 6 109464 280 90518697
Nasal polyps 11.46 10.02 34 109436 10846 90508131
Normal newborn 11.46 10.02 7 109463 23355 90495622
Incision site pain 11.44 10.02 11 109459 1367 90517610
Kussmaul respiration 11.41 10.02 6 109464 283 90518694
Dermatitis 11.30 10.02 55 109415 22165 90496812
Thrombophlebitis septic 11.28 10.02 6 109464 290 90518687
Haematidrosis 11.19 10.02 4 109466 72 90518905
Meningitis bacterial 11.14 10.02 12 109458 1705 90517272
Dizziness 11.14 10.02 590 108880 588694 89930283
Osteopenia 11.14 10.02 7 109463 22995 90495982
Guillain-Barre syndrome 11.14 10.02 20 109450 4592 90514385
Drug intolerance 11.12 10.02 435 109035 447156 90071821
Trunk injury 11.07 10.02 3 109467 20 90518957
Vasculitis necrotising 10.99 10.02 8 109462 676 90518301
Injection site urticaria 10.98 10.02 4 109466 18007 90500970
Laryngeal haematoma 10.95 10.02 3 109467 21 90518956
Anal candidiasis 10.95 10.02 3 109467 21 90518956
Peritonitis 10.92 10.02 50 109420 19655 90499322
Haematuria 10.92 10.02 76 109394 34861 90484116
Liver abscess 10.90 10.02 17 109453 3479 90515498
Arteritis 10.88 10.02 8 109462 687 90518290
Injection site rash 10.84 10.02 8 109462 24165 90494812
Pericarditis tuberculous 10.83 10.02 3 109467 22 90518955
Focal dyscognitive seizures 10.81 10.02 16 109454 3128 90515849
Keratic precipitates 10.79 10.02 6 109464 317 90518660
Subretinal fluid 10.78 10.02 8 109462 696 90518281
Vaginal discharge 10.77 10.02 5 109465 19459 90499518
Renal arteriosclerosis 10.71 10.02 5 109465 182 90518795
Ecchymosis 10.68 10.02 36 109434 12287 90506690
Nephrogenic anaemia 10.65 10.02 14 109456 2452 90516525
Autoimmune hepatitis 10.58 10.02 32 109438 10319 90508658
Engraftment syndrome 10.57 10.02 8 109462 717 90518260
Motor dysfunction 10.55 10.02 5 109465 19225 90499752
Nodule 10.53 10.02 10 109460 26676 90492301
Seizure 10.52 10.02 250 109220 152379 90366598
Gastrointestinal necrosis 10.50 10.02 16 109454 3209 90515768
Lip erosion 10.50 10.02 10 109460 1228 90517749
Tachycardia 10.49 10.02 257 109213 157416 90361561
Mycobacterium fortuitum infection 10.49 10.02 4 109466 87 90518890
Hypoglycaemic encephalopathy 10.49 10.02 6 109464 335 90518642
Shock 10.45 10.02 65 109405 28713 90490264
Intentional self-injury 10.44 10.02 12 109458 29322 90489655
Hypersensitivity 10.42 10.02 446 109024 454231 90064746
Rectal haemorrhage 10.39 10.02 58 109412 82686 90436291
Injection site mass 10.32 10.02 7 109463 22083 90496894
Breast cancer 10.30 10.02 32 109438 53729 90465248
Disseminated sporotrichosis 10.29 10.02 3 109467 27 90518950
Therapy partial responder 10.28 10.02 7 109463 22036 90496941
Pemphigoid 10.28 10.02 29 109441 8997 90509980
Disseminated tuberculosis 10.23 10.02 16 109454 3283 90515694
Leukoderma 10.20 10.02 4 109466 94 90518883
Anaemia folate deficiency 10.20 10.02 7 109463 539 90518438
Forced expiratory volume decreased 10.16 10.02 22 109448 5786 90513191
Vocal cord operation 10.16 10.02 4 109466 95 90518882
Cutaneous vasculitis 10.11 10.02 25 109445 7168 90511809
Systemic candida 10.10 10.02 20 109450 4939 90514038
Chronic graft versus host disease 10.06 10.02 18 109452 4121 90514856

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tendon rupture 486.14 10.94 273 95206 7810 42518046
Tendonitis 457.77 10.94 282 95197 9612 42516244
Tendon pain 364.27 10.94 168 95311 3132 42522724
Tendon disorder 320.24 10.94 155 95324 3234 42522622
Drug reaction with eosinophilia and systemic symptoms 302.40 10.94 420 95059 41655 42484201
Pulmonary vasculitis 210.05 10.94 146 95333 6120 42519736
Spirometry abnormal 201.42 10.94 132 95347 5014 42520842
Full blood count abnormal 199.48 10.94 288 95191 29588 42496268
Febrile neutropenia 194.95 10.94 878 94601 184825 42341031
Neuritis 187.87 10.94 136 95343 6084 42519772
Mycotic allergy 185.47 10.94 123 95356 4768 42521088
Conjunctivitis allergic 184.84 10.94 132 95347 5779 42520077
Mite allergy 184.37 10.94 124 95355 4922 42520934
Dust allergy 178.17 10.94 124 95355 5208 42520648
Pulmonary alveolar haemorrhage 174.83 10.94 190 95289 14626 42511230
Normochromic normocytic anaemia 155.01 10.94 142 95337 8889 42516967
Drug abuse 151.73 10.94 26 95453 104745 42421111
Eosinophilic granulomatosis with polyangiitis 150.57 10.94 137 95342 8501 42517355
Toxicity to various agents 143.17 10.94 182 95297 228954 42296902
Obstructive airways disorder 142.90 10.94 223 95256 24536 42501320
Completed suicide 141.77 10.94 23 95456 96442 42429414
Neurological symptom 133.66 10.94 137 95342 9854 42516002
Pneumonia 131.89 10.94 1484 93995 420665 42105191
Productive cough 131.10 10.94 329 95150 51238 42474618
Respiratory symptom 128.55 10.94 141 95338 10965 42514891
Wheezing 127.41 10.94 338 95141 54443 42471413
Vasculitis 126.70 10.94 180 95299 18214 42507642
Total lung capacity abnormal 124.82 10.94 93 95386 4350 42521506
Pyrexia 122.02 10.94 1383 94096 392659 42133197
Electrocardiogram QT prolonged 116.78 10.94 301 95178 47644 42478212
Nodule 109.87 10.94 138 95341 12396 42513460
Congenital hiatus hernia 107.76 10.94 98 95381 6076 42519780
Sleep disorder due to a general medical condition 106.05 10.94 161 95318 17292 42508564
Malignant melanoma in situ 105.91 10.94 70 95409 2697 42523159
Drug resistance 104.91 10.94 235 95244 34013 42491843
Tendon discomfort 103.42 10.94 37 95442 343 42525513
Cholestasis 95.60 10.94 221 95258 32658 42493198
Forced expiratory volume decreased 93.78 10.94 100 95379 7530 42518326
Rash maculo-papular 89.83 10.94 234 95245 37269 42488587
Pathogen resistance 89.31 10.94 119 95360 11331 42514525
Asthma 88.58 10.94 324 95155 61990 42463866
Drug hypersensitivity 86.76 10.94 446 95033 98943 42426913
Neuropathy peripheral 84.73 10.94 451 95028 101402 42424454
Haemoptysis 82.31 10.94 259 95220 45908 42479948
Weight increased 81.59 10.94 73 95406 107910 42417946
Breath sounds abnormal 81.30 10.94 117 95362 11976 42513880
Foetal exposure during pregnancy 80.01 10.94 7 95472 47304 42478552
Intentional overdose 78.48 10.94 11 95468 51445 42474411
Inappropriate schedule of product administration 78.43 10.94 60 95419 95842 42430014
Vascular purpura 78.14 10.94 53 95426 2133 42523723
Acute myeloid leukaemia 77.65 10.94 161 95318 22095 42503761
Neutropenia 77.62 10.94 734 94745 198697 42327159
Loss of personal independence in daily activities 75.90 10.94 265 95214 49551 42476305
Eosinophilia 75.46 10.94 202 95277 32697 42493159
Delusion of grandeur 75.20 10.94 50 95429 1946 42523910
Product dose omission issue 74.12 10.94 146 95333 154219 42371637
Antineutrophil cytoplasmic antibody positive 73.67 10.94 68 95411 4297 42521559
Arteriosclerosis coronary artery 73.41 10.94 142 95337 18535 42507321
Immune reconstitution inflammatory syndrome 70.94 10.94 100 95379 10043 42515813
Myocardial infarction 70.80 10.94 105 95374 123904 42401952
Thrombocytopenia 69.93 10.94 692 94787 189587 42336269
Somnolence 69.89 10.94 131 95348 140974 42384882
Hepatitis cholestatic 67.44 10.94 96 95383 9728 42516128
Arteriosclerosis 67.35 10.94 134 95345 17855 42508001
Dizziness 66.87 10.94 309 95170 248945 42276911
Lip oedema 66.54 10.94 56 95423 3128 42522728
Toxic skin eruption 66.14 10.94 114 95365 13616 42512240
Hepatocellular injury 64.31 10.94 155 95324 23523 42502333
Headache 62.87 10.94 299 95180 239070 42286786
Affective disorder 62.69 10.94 72 95407 5888 42519968
Hypoxia 62.15 10.94 315 95164 69471 42456385
Rhinalgia 61.88 10.94 43 95436 1801 42524055
Cerebrovascular accident 61.80 10.94 76 95403 97084 42428772
Eosinophilic pneumonia acute 61.40 10.94 32 95447 785 42525071
Fall 60.98 10.94 294 95185 234226 42291630
Pulmonary fibrosis 60.36 10.94 163 95316 26518 42499338
Dysbiosis 59.13 10.94 31 95448 770 42525086
Cytokine release syndrome 57.86 10.94 225 95254 44302 42481554
Benign prostatic hyperplasia 57.38 10.94 138 95341 20914 42504942
Pancytopenia 57.04 10.94 455 95024 117288 42408568
Bronchopulmonary aspergillosis 55.81 10.94 130 95349 19299 42506557
Tracheobronchomegaly 55.51 10.94 13 95466 17 42525839
Lymphocyte count abnormal 55.31 10.94 43 95436 2144 42523712
Injection site pain 54.21 10.94 31 95448 57767 42468089
Stress 53.91 10.94 16 95463 44196 42481660
Hypothyroidism 53.55 10.94 176 95303 31908 42493948
Fatigue 53.29 10.94 673 94806 434968 42090888
Fixed eruption 53.02 10.94 44 95435 2410 42523446
Platelet count decreased 52.33 10.94 507 94972 138074 42387782
Therapeutic product effect incomplete 51.57 10.94 303 95176 70636 42455220
Vertebral artery dissection 51.48 10.94 13 95466 28 42525828
Clostridium difficile colitis 51.28 10.94 133 95346 21119 42504737
Suicide attempt 50.48 10.94 20 95459 46080 42479776
Purpura 50.00 10.94 93 95386 11786 42514070
Therapeutic product effect decreased 49.92 10.94 13 95466 39137 42486719
Myoclonus 48.82 10.94 114 95365 16951 42508905
Aortitis 47.32 10.94 25 95454 631 42525225
Chorea 46.88 10.94 33 95446 1411 42524445
Neutrophil count decreased 46.83 10.94 272 95207 63143 42462713
Blood pressure increased 46.69 10.94 99 95380 101829 42424027
Bronchiectasis 45.80 10.94 115 95364 17904 42507952
Blood bilirubin increased 45.08 10.94 201 95278 42051 42483805
Drug dependence 44.88 10.94 6 95473 29088 42496768
Cross sensitivity reaction 44.69 10.94 34 95445 1641 42524215
Chest pain 44.22 10.94 162 95317 139368 42386488
Lymphocyte count decreased 44.15 10.94 150 95329 27659 42498197
Lung disorder 42.43 10.94 216 95263 47707 42478149
Drug-induced liver injury 42.30 10.94 184 95295 38089 42487767
Psoriatic arthropathy 41.39 10.94 4 95475 24963 42500893
Agranulocytosis 40.83 10.94 156 95323 30456 42495400
Toxic epidermal necrolysis 40.47 10.94 142 95337 26608 42499248
Micturition urgency 40.25 10.94 85 95394 11813 42514043
Sedation 39.08 10.94 10 95469 30465 42495391
Degenerative mitral valve disease 38.98 10.94 17 95462 276 42525580
Acute myocardial infarction 38.57 10.94 44 95435 58121 42467735
Death 38.47 10.94 785 94694 470400 42055456
Ballismus 38.23 10.94 13 95466 102 42525754
Capillaritis 38.17 10.94 35 95444 2193 42523663
Aortic rupture 37.69 10.94 13 95466 107 42525749
Respiratory failure 37.28 10.94 445 95034 127687 42398169
Weight decreased 36.68 10.94 294 95185 207654 42318202
Paradoxical drug reaction 36.58 10.94 49 95430 4689 42521167
Psoriasis 36.52 10.94 33 95446 48571 42477285
Septic shock 35.87 10.94 338 95141 91334 42434522
Eosinophilic pneumonia 35.49 10.94 49 95430 4825 42521031
Rheumatoid arthritis 35.39 10.94 26 95453 42414 42483442
General physical health deterioration 35.10 10.94 197 95282 151049 42374807
Joint injury 34.54 10.94 91 95388 14585 42511271
Conjunctival hyperaemia 34.47 10.94 39 95440 3137 42522719
Neurotoxicity 34.45 10.94 124 95355 23527 42502329
Diabetes mellitus 34.15 10.94 51 95428 60036 42465820
Musculoskeletal stiffness 33.84 10.94 48 95431 57717 42468139
Feeling abnormal 33.46 10.94 66 95413 69720 42456136
Drug intolerance 32.89 10.94 83 95396 80341 42445515
Bradycardia 32.85 10.94 91 95388 85393 42440463
Hepatic cytolysis 32.73 10.94 133 95346 26711 42499145
Tubulointerstitial nephritis 32.10 10.94 148 95331 31400 42494456
Blood cholesterol increased 32.02 10.94 10 95469 26731 42499125
Nephrolithiasis 31.45 10.94 22 95457 36808 42489048
Tracheal oedema 31.44 10.94 8 95471 18 42525838
Respiratory depression 31.34 10.94 3 95476 18865 42506991
Chronic pigmented purpura 31.01 10.94 12 95467 141 42525715
Blood pressure fluctuation 30.58 10.94 11 95468 26897 42498959
Prostate cancer 30.44 10.94 33 95446 44610 42481246
Nicotine dependence 30.14 10.94 19 95460 674 42525182
Acute kidney injury 30.06 10.94 1054 94425 366283 42159573
Palatal oedema 30.03 10.94 22 95457 1002 42524854
Pain 29.93 10.94 378 95101 244470 42281386
Accidental exposure to product 29.63 10.94 5 95474 20388 42505468
Myoclonic dystonia 29.57 10.94 10 95469 77 42525779
Hypercholesterolaemia 29.56 10.94 79 95400 12770 42513086
Candida infection 29.54 10.94 111 95368 21499 42504357
Cardiogenic shock 29.50 10.94 22 95457 35618 42490238
Aspartate aminotransferase increased 29.43 10.94 283 95196 76880 42448976
Pneumothorax spontaneous 29.03 10.94 20 95459 826 42525030
Pneumonitis 28.90 10.94 176 95303 41542 42484314
Dermatitis exfoliative generalised 28.89 10.94 49 95430 5775 42520081
No adverse event 28.71 10.94 27 95452 38994 42486862
Mucosal inflammation 28.53 10.94 199 95280 49175 42476681
Musculoskeletal injury 28.07 10.94 11 95468 134 42525722
Migraine 27.86 10.94 11 95468 25403 42500453
Plasma cell myeloma 27.63 10.94 192 95287 47386 42478470
Alanine aminotransferase increased 27.47 10.94 311 95168 88095 42437761
Clostridium difficile infection 27.42 10.94 112 95367 22547 42503309
Serotonin syndrome 27.02 10.94 12 95467 25833 42500023
Haemophagocytic lymphohistiocytosis 26.93 10.94 96 95383 18126 42507730
White blood cell count decreased 26.86 10.94 371 95108 110025 42415831
Abdominal pain 26.78 10.94 285 95194 190186 42335670
Pseudomembranous colitis 26.67 10.94 34 95445 3099 42522757
Unmasking of previously unidentified disease 26.48 10.94 22 95457 1207 42524649
Klebsiella infection 26.40 10.94 70 95409 11262 42514594
Factor V inhibition 26.29 10.94 12 95467 218 42525638
Encephalopathy 25.91 10.94 170 95309 41163 42484693
Hypocoagulable state 25.80 10.94 20 95459 993 42524863
Respiratory arrest 25.59 10.94 16 95463 28408 42497448
Idiopathic orbital inflammation 25.59 10.94 9 95470 79 42525777
Coma 25.37 10.94 51 95428 53503 42472353
Lateral medullary syndrome 25.37 10.94 8 95471 48 42525808
Pulmonary vascular disorder 25.35 10.94 17 95462 671 42525185
Torsade de pointes 25.22 10.94 58 95421 8536 42517320
Intentional product misuse 25.21 10.94 64 95415 61836 42464020
Fusarium infection 25.02 10.94 24 95455 1592 42524264
Long QT syndrome 24.83 10.94 33 95446 3134 42522722
Aminoaciduria 24.71 10.94 12 95467 252 42525604
Pain in extremity 24.30 10.94 473 95006 150131 42375725
Malaise 24.27 10.94 332 95147 211824 42314032
Disseminated mucormycosis 24.12 10.94 22 95457 1369 42524487
Neuroleptic malignant syndrome 24.02 10.94 9 95470 21463 42504393
Overdose 23.92 10.94 138 95341 105126 42420730
Acute myeloid leukaemia recurrent 23.63 10.94 34 95445 3478 42522378
Suicidal ideation 23.56 10.94 45 95434 48116 42477740
Fungaemia 23.55 10.94 32 95447 3104 42522752
Wrong technique in product usage process 23.44 10.94 37 95442 42598 42483258
Ventricular enlargement 23.09 10.94 16 95463 667 42525189
Infection in an immunocompromised host 22.94 10.94 19 95460 1038 42524818
Injection site swelling 22.88 10.94 5 95474 16968 42508888
Rectal haemorrhage 22.85 10.94 48 95431 49558 42476298
Mixed liver injury 22.67 10.94 38 95441 4436 42521420
Inferior vena cava dilatation 22.67 10.94 17 95462 803 42525053
Helicobacter test positive 22.59 10.94 17 95462 807 42525049
Subacute endocarditis 22.57 10.94 8 95471 72 42525784
Intentional product use issue 22.34 10.94 84 95395 71749 42454107
Gluten sensitivity 21.92 10.94 7 95472 44 42525812
Phrenic nerve paralysis 21.79 10.94 10 95469 184 42525672
Joint noise 21.69 10.94 18 95461 986 42524870
Hepatic function abnormal 21.61 10.94 193 95286 51374 42474482
Accidental overdose 21.56 10.94 19 95460 28311 42497545
Tuberculoma of central nervous system 21.55 10.94 11 95468 258 42525598
Bronchostenosis 21.55 10.94 13 95466 426 42525430
Eye injury 21.53 10.94 18 95461 996 42524860
Lower respiratory tract infection 21.50 10.94 37 95442 41169 42484687
Ecthyma 21.07 10.94 15 95464 653 42525203
Drug withdrawal syndrome 21.01 10.94 11 95468 21538 42504318
Angular cheilitis 20.99 10.94 10 95469 201 42525655
Tendon injury 20.98 10.94 18 95461 1032 42524824
Diabetic ketoacidosis 20.96 10.94 12 95467 22355 42503501
Capillary permeability increased 20.82 10.94 6 95473 25 42525831
Lactobacillus infection 20.78 10.94 12 95467 362 42525494
Dehydration 20.78 10.94 210 95269 141557 42384299
Colitis ulcerative 20.60 10.94 17 95462 26158 42499698
Therapeutic response shortened 20.42 10.94 3 95476 13551 42512305
Sebaceous adenitis 20.41 10.94 4 95475 0 42525856
Tuberculosis of central nervous system 20.34 10.94 10 95469 216 42525640
Normocytic anaemia 20.33 10.94 32 95447 3545 42522311
SARS-CoV-2 test positive 20.24 10.94 52 95427 8208 42517648
Cardiac aneurysm 20.22 10.94 18 95461 1085 42524771
Weight bearing difficulty 20.21 10.94 19 95460 1229 42524627
Leukopenia 20.17 10.94 256 95223 74490 42451366
Demodicidosis 20.09 10.94 10 95469 222 42525634
Disseminated intravascular coagulation 20.05 10.94 109 95370 24685 42501171
Nervous system disorder 20.02 10.94 84 95395 17111 42508745
Muscle rupture 20.02 10.94 26 95453 2414 42523442
Nephrogenic diabetes insipidus 20.00 10.94 21 95458 1553 42524303
Ulcerative keratitis 19.93 10.94 24 95455 2064 42523792
Pneumonia legionella 19.92 10.94 25 95454 2243 42523613
Fat tissue decreased 19.74 10.94 8 95471 107 42525749
Dry skin 19.67 10.94 50 95429 48288 42477568
Henoch-Schonlein purpura 19.36 10.94 24 95455 2126 42523730
Haematoma muscle 19.36 10.94 24 95455 2126 42523730
Time perception altered 19.35 10.94 8 95471 113 42525743
Tubulointerstitial nephritis and uveitis syndrome 19.35 10.94 8 95471 113 42525743
Frequent bowel movements 19.34 10.94 12 95467 21395 42504461
Gallbladder empyema 19.28 10.94 7 95472 68 42525788
Hepatotoxicity 19.25 10.94 109 95370 25058 42500798
Hypoglycaemia 19.24 10.94 212 95267 59642 42466214
Delirium 19.23 10.94 191 95288 52328 42473528
Small fibre neuropathy 19.20 10.94 10 95469 245 42525611
Haematochezia 19.05 10.94 67 95412 58369 42467487
Precancerous condition 19.04 10.94 8 95471 118 42525738
Irritability 18.95 10.94 21 95458 28107 42497749
Incorrect route of product administration 18.86 10.94 16 95463 24289 42501567
Corneal opacity 18.86 10.94 14 95465 651 42525205
Nasal congestion 18.82 10.94 23 95456 29478 42496378
Respiratory muscle weakness 18.80 10.94 8 95471 122 42525734
Therapeutic response decreased 18.62 10.94 34 95445 36978 42488878
Pneumonia bacterial 18.54 10.94 77 95402 15615 42510241
Corynebacterium test positive 18.38 10.94 5 95474 16 42525840
Drug eruption 18.36 10.94 101 95378 22974 42502882
Malignant neoplasm progression 18.29 10.94 155 95324 108245 42417611
Device issue 18.17 10.94 4 95475 13505 42512351
Multiple organ dysfunction syndrome 18.17 10.94 312 95167 96723 42429133
Abdominal discomfort 18.00 10.94 97 95382 75158 42450698
Cardiac failure congestive 17.99 10.94 115 95364 85487 42440369
Heart rate decreased 17.99 10.94 34 95445 36498 42489358
Hypoalbuminaemia 17.97 10.94 76 95403 15534 42510322
Respiratory distress 17.77 10.94 157 95322 41663 42484193
Haemarthrosis 17.71 10.94 32 95447 3966 42521890
Immune effector cell-associated neurotoxicity syndrome 17.70 10.94 54 95425 9407 42516449
Hypertension 17.58 10.94 266 95213 166938 42358918
Botulism 17.56 10.94 9 95470 213 42525643
Hyperbilirubinaemia 17.56 10.94 92 95387 20543 42505313
FEV1/FVC ratio abnormal 17.55 10.94 6 95473 48 42525808
Herpes dermatitis 17.50 10.94 8 95471 146 42525710
Bicytopenia 17.43 10.94 28 95451 3156 42522700
Thrombosis 17.37 10.94 232 95247 68279 42457577
Hyperhidrosis 17.33 10.94 125 95354 90387 42435469
Renal ischaemia 17.27 10.94 20 95459 1650 42524206
Paranoia 17.23 10.94 5 95474 14021 42511835
Allergic cough 17.23 10.94 6 95473 51 42525805
Dry mouth 17.21 10.94 40 95439 39839 42486017
Surgery 17.16 10.94 9 95470 17607 42508249
Diabetic bullosis 17.14 10.94 5 95474 22 42525834
Sleep apnoea syndrome 17.04 10.94 14 95465 21594 42504262
Glycosylated haemoglobin increased 17.04 10.94 4 95475 12920 42512936
Sepsis 17.01 10.94 575 94904 198759 42327097
Bronchitis 16.96 10.94 171 95308 47030 42478826
Drug ineffective for unapproved indication 16.95 10.94 168 95311 45995 42479861
Crystal nephropathy 16.93 10.94 13 95466 636 42525220
Syncope 16.83 10.94 142 95337 99264 42426592
Prostate tenderness 16.83 10.94 6 95473 55 42525801
Schizophrenia 16.82 10.94 57 95422 10493 42515363
Corneal exfoliation 16.76 10.94 4 95475 6 42525850
Skin hyperpigmentation 16.69 10.94 32 95447 4149 42521707
Retinal pigment epithelial tear 16.68 10.94 10 95469 324 42525532
Neutrophil count increased 16.65 10.94 88 95391 19716 42506140
Urinary tract inflammation 16.62 10.94 9 95470 239 42525617
Mast cell activation syndrome 16.57 10.94 10 95469 328 42525528
Arthritis fungal 16.55 10.94 7 95472 105 42525751
Eczema 16.54 10.94 32 95447 34054 42491802
Ligament pain 16.46 10.94 6 95473 59 42525797
Peripheral sensory neuropathy 16.39 10.94 50 95429 8712 42517144
Cramp-fasciculation syndrome 16.38 10.94 4 95475 7 42525849
Illness 16.37 10.94 19 95460 24911 42500945
Painful ejaculation 16.35 10.94 8 95471 171 42525685
Leukocytosis 16.15 10.94 118 95361 29590 42496266
Nasopharyngitis 16.08 10.94 116 95363 83880 42441976
Acute generalised exanthematous pustulosis 16.03 10.94 49 95430 8546 42517310
Organising pneumonia 16.02 10.94 45 95434 7487 42518369
Bronchial haemorrhage 16 10.94 13 95466 691 42525165
Intentional self-injury 15.98 10.94 7 95472 15195 42510661
Immune reconstitution inflammatory syndrome associated tuberculosis 15.96 10.94 12 95467 569 42525287
Product substitution issue 15.90 10.94 3 95476 11287 42514569
Sputum purulent 15.87 10.94 13 95466 699 42525157
Therapy partial responder 15.76 10.94 13 95466 20008 42505848
Ciliary hyperaemia 15.58 10.94 5 95474 32 42525824
Dermatitis bullous 15.58 10.94 48 95431 8408 42517448
Intestinal obstruction 15.47 10.94 23 95456 27135 42498721
Acute respiratory distress syndrome 15.46 10.94 118 95361 29990 42495866
Nightmare 15.43 10.94 20 95459 24992 42500864
Sensitisation 15.42 10.94 9 95470 277 42525579
Phlebosclerosis 15.40 10.94 7 95472 126 42525730
Blast cell count increased 15.40 10.94 16 95463 1169 42524687
Pneumonia pseudomonal 15.38 10.94 34 95445 4875 42520981
Injection site reaction 15.37 10.94 8 95471 15713 42510143
Infusion related reaction 15.31 10.94 77 95402 60729 42465127
Toxic optic neuropathy 15.27 10.94 15 95464 1025 42524831
Withdrawal syndrome 15.23 10.94 7 95472 14768 42511088
Dementia 15.22 10.94 9 95470 16471 42509385
Linear IgA disease 15.10 10.94 21 95458 2082 42523774
Blood glucose increased 14.98 10.94 100 95379 73599 42452257
Dystonia 14.93 10.94 5 95474 12785 42513071
Wound 14.91 10.94 10 95469 17107 42508749
Abdominal pain upper 14.90 10.94 116 95363 82493 42443363
Ascites 14.72 10.94 71 95408 56607 42469249
Muscle discomfort 14.69 10.94 8 95471 215 42525641
Candida endophthalmitis 14.64 10.94 7 95472 142 42525714
Miosis 14.44 10.94 6 95473 13440 42512416
Aspergillus infection 14.44 10.94 72 95407 15765 42510091
Multiple sclerosis relapse 14.33 10.94 7 95472 14257 42511599
Dermatitis atopic 14.21 10.94 5 95474 12399 42513457
Anterior chamber flare 14.19 10.94 6 95473 90 42525766
Impaired quality of life 14.18 10.94 7 95472 14170 42511686
Therapeutic response unexpected 14.09 10.94 4 95475 11377 42514479
Occult blood 14.06 10.94 14 95465 972 42524884
Peptic ulcer haemorrhage 14.03 10.94 12 95467 685 42525171
Burn oesophageal 13.95 10.94 6 95473 94 42525762
Skin erosion 13.92 10.94 24 95455 2867 42522989
Perineal pain 13.88 10.94 14 95465 987 42524869
Diplopia 13.87 10.94 15 95464 20301 42505555
Polyserositis 13.87 10.94 9 95470 336 42525520
Chronic fatigue syndrome 13.84 10.94 9 95470 337 42525519
Obesity 13.83 10.94 10 95469 16449 42509407
Oesophageal oedema 13.82 10.94 4 95475 17 42525839
Vitreous detachment 13.71 10.94 14 95465 1002 42524854
Chronic obstructive pulmonary disease 13.71 10.94 208 95271 62906 42462950
Sensory level abnormal 13.64 10.94 5 95474 50 42525806
Product storage error 13.64 10.94 4 95475 11136 42514720
Oedema 13.56 10.94 177 95302 51824 42474032
Duodenal stenosis 13.52 10.94 9 95470 351 42525505
Ischaemic stroke 13.49 10.94 18 95461 22215 42503641
Diabetes mellitus inadequate control 13.39 10.94 9 95470 15381 42510475
Anaphylactoid reaction 13.37 10.94 24 95455 2959 42522897
Pneumonia fungal 13.36 10.94 48 95431 9098 42516758
Erectile dysfunction 13.34 10.94 22 95457 24891 42500965
Toxic encephalopathy 13.31 10.94 40 95439 6913 42518943
Amoebic colitis 13.30 10.94 6 95473 106 42525750
Hyposmia 13.29 10.94 9 95470 361 42525495
Bilirubin conjugated increased 13.29 10.94 27 95452 3650 42522206
Cardiac murmur 13.25 10.94 6 95473 12769 42513087
Epididymal disorder 13.24 10.94 3 95476 3 42525853
Red blood cell sedimentation rate increased 13.23 10.94 3 95476 9921 42515935
Persistent corneal epithelial defect 13.22 10.94 5 95474 55 42525801
Head injury 13.18 10.94 16 95463 20566 42505290
Hypersensitivity vasculitis 13.16 10.94 25 95454 3219 42522637
Hallucination, auditory 13.15 10.94 67 95412 14797 42511059
Infective pulmonary exacerbation of cystic fibrosis 13.14 10.94 43 95436 7775 42518081
Product administration error 13.14 10.94 13 95466 18330 42507526
Axonal neuropathy 13.12 10.94 15 95464 1220 42524636
Systolic dysfunction 13.11 10.94 24 95455 3004 42522852
Troponin increased 13.09 10.94 14 95465 19048 42506808
Haematotoxicity 13.05 10.94 54 95425 10931 42514925
Sinusitis fungal 12.99 10.94 12 95467 759 42525097
Colour blindness acquired 12.90 10.94 6 95473 114 42525742
Vertigo 12.86 10.94 37 95442 34310 42491546
Plasma cell myeloma in remission 12.83 10.94 4 95475 23 42525833
Pelvic discomfort 12.78 10.94 3 95476 4 42525852
Dysarthria 12.73 10.94 46 95433 39761 42486095
Bacterial translocation 12.66 10.94 11 95468 642 42525214
Respiratory gas exchange disorder 12.65 10.94 10 95469 511 42525345
Hydrocephalus 12.62 10.94 36 95443 6042 42519814
Injection site bruising 12.61 10.94 5 95474 11520 42514336
Jarisch-Herxheimer reaction 12.57 10.94 12 95467 791 42525065
Arthropathy 12.52 10.94 30 95449 29567 42496289
Abdominal distension 12.35 10.94 102 95377 71633 42454223
Peripheral swelling 12.29 10.94 136 95343 90134 42435722
Meningitis tuberculous 12.29 10.94 11 95468 668 42525188
Pseudomonas bronchitis 12.28 10.94 4 95475 27 42525829
CD4/CD8 ratio decreased 12.16 10.94 4 95475 28 42525828
Rash morbilliform 12.16 10.94 28 95451 4125 42521731
Prolonged expiration 12.08 10.94 8 95471 309 42525547
Haematocrit decreased 12.08 10.94 39 95440 34869 42490987
Road traffic accident 12.06 10.94 15 95464 19078 42506778
Laryngotracheal oedema 12.03 10.94 3 95476 6 42525850
Lethargy 12.02 10.94 59 95420 46831 42479025
Stevens-Johnson syndrome 12.00 10.94 88 95391 22090 42503766
Stenotrophomonas infection 12.00 10.94 26 95453 3678 42522178
Thrombotic microangiopathy 11.96 10.94 65 95414 14717 42511139
Corneal oedema 11.93 10.94 16 95463 1532 42524324
Electrocardiogram T wave biphasic 11.92 10.94 7 95472 218 42525638
Amnesia 11.89 10.94 29 95450 28408 42497448
Gastrointestinal haemorrhage 11.86 10.94 151 95328 97575 42428281
Memory impairment 11.86 10.94 65 95414 50157 42475699
Hyperkalaemia 11.86 10.94 119 95360 80339 42445517
Cataract subcapsular 11.81 10.94 10 95469 563 42525293
Peripheral sensorimotor neuropathy 11.80 10.94 18 95461 1940 42523916
Rotator cuff syndrome 11.78 10.94 37 95442 6549 42519307
Geotrichum infection 11.75 10.94 10 95469 567 42525289
Hypotension 11.74 10.94 465 95014 257166 42268690
Blood triglycerides increased 11.69 10.94 11 95468 15885 42509971
Respiratory disorder 11.59 10.94 87 95392 21998 42503858
Therapy non-responder 11.56 10.94 71 95408 53288 42472568
Keratic precipitates 11.50 10.94 7 95472 233 42525623
Anal stenosis 11.47 10.94 8 95471 337 42525519
Muscle atrophy 11.47 10.94 43 95436 8318 42517538
Heart rate increased 11.47 10.94 71 95408 53184 42472672
Malabsorption from administration site 11.42 10.94 5 95474 82 42525774
Ejection fraction decreased 11.37 10.94 20 95459 22067 42503789
Product quality issue 11.34 10.94 14 95465 17868 42507988
Interleukin level increased 11.31 10.94 12 95467 898 42524958
Oliguria 11.24 10.94 46 95433 9267 42516589
Bacteraemia 11.15 10.94 95 95384 24945 42500911
Morganella infection 11.14 10.94 10 95469 609 42525247
Discomfort 11.12 10.94 25 95454 25194 42500662
Depression 11.08 10.94 179 95300 111184 42414672
Cell death 11.02 10.94 22 95457 2937 42522919
Therapy cessation 11.00 10.94 18 95461 20432 42505424
Optic neuropathy 10.99 10.94 20 95459 2492 42523364
International normalised ratio increased 10.95 10.94 160 95319 48008 42477848

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Tendon pain 945.46 10.16 366 182752 5960 110400221
Tendon rupture 891.17 10.16 445 182673 13633 110392548
Drug reaction with eosinophilia and systemic symptoms 839.92 10.16 847 182271 81248 110324933
Tendonitis 783.01 10.16 506 182612 25577 110380604
Tendon disorder 690.50 10.16 317 182801 8020 110398161
Febrile neutropenia 549.25 10.16 1448 181670 315319 110090862
Creatinine renal clearance decreased 545.98 10.16 378 182740 21437 110384744
Sedation complication 525.21 10.16 356 182762 19499 110386682
Blood calcium decreased 438.21 10.16 408 182710 35437 110370744
Drug hypersensitivity 430.57 10.16 1687 181431 452403 109953778
Hand deformity 340.14 10.16 4 183114 218502 110187679
Orthostatic hypotension 331.22 10.16 475 182643 65774 110340407
Arthropathy 330.21 10.16 43 183075 287479 110118702
Synovitis 303.01 10.16 46 183072 274046 110132135
Glossodynia 298.68 10.16 17 183101 221987 110184194
Cognitive disorder 296.15 10.16 525 182593 86986 110319195
Pemphigus 293.14 10.16 15 183103 214555 110191626
Maternal exposure during pregnancy 276.70 10.16 45 183073 254838 110151343
Systemic lupus erythematosus 275.90 10.16 45 183073 254293 110151888
Completed suicide 258.22 10.16 45 183073 242336 110163845
Psoriatic arthropathy 255.94 10.16 18 183100 196743 110209438
Electrocardiogram QT prolonged 255.10 10.16 560 182558 108400 110297781
Pyrexia 253.15 10.16 2431 180687 895834 109510347
Weight increased 252.76 10.16 195 182923 419449 109986732
Pneumonia 249.67 10.16 2378 180740 874336 109531845
Pulmonary vasculitis 246.87 10.16 147 182971 6413 110399768
Duodenal ulcer perforation 244.07 10.16 12 183106 177688 110228493
Spirometry abnormal 243.62 10.16 137 182981 5360 110400821
Sedation 242.17 10.16 423 182695 69260 110336921
Wound 238.09 10.16 49 183069 234388 110171793
Helicobacter infection 235.51 10.16 17 183101 181860 110224321
Depressed level of consciousness 232.83 10.16 550 182568 111728 110294453
Drug resistance 230.36 10.16 368 182750 56006 110350175
Rash maculo-papular 229.19 10.16 428 182690 73794 110332387
Thrombocytopenia 215.51 10.16 1143 181975 347742 110058439
Neutropenia 215.05 10.16 1203 181915 373417 110032764
Conjunctivitis allergic 214.23 10.16 137 182981 6794 110399387
Blood cholesterol increased 211.23 10.16 28 183090 184757 110221424
Impaired healing 210.67 10.16 36 183082 196681 110209500
Mite allergy 207.92 10.16 126 182992 5677 110400504
Folliculitis 205.18 10.16 20 183098 167633 110238548
Mycotic allergy 204.93 10.16 126 182992 5828 110400353
Pericarditis 204.32 10.16 55 183063 219059 110187122
Pulmonary alveolar haemorrhage 204.27 10.16 207 182911 19943 110386238
Dust allergy 204.02 10.16 126 182992 5875 110400306
Neuritis 203.65 10.16 136 182982 7263 110398918
Neuropathy peripheral 201.24 10.16 704 182414 178573 110227608
Balance disorder 196.68 10.16 528 182590 116032 110290149
Pathogen resistance 196.65 10.16 191 182927 17481 110388700
Irritable bowel syndrome 194.77 10.16 22 183096 164193 110241988
Eosinophilia 190.11 10.16 343 182775 57593 110348588
Cholestasis 188.02 10.16 363 182755 64155 110342026
Discomfort 185.48 10.16 62 183056 214645 110191536
Muscle injury 182.76 10.16 13 183105 140794 110265387
Joint swelling 181.40 10.16 283 182835 442562 109963619
International normalised ratio fluctuation 178.96 10.16 101 183017 3979 110402202
Hypoxia 178.07 10.16 545 182573 128970 110277211
Eosinophilic granulomatosis with polyangiitis 171.46 10.16 142 182976 10544 110395637
Respiratory failure 167.66 10.16 754 182364 214578 110191603
Musculoskeletal stiffness 164.64 10.16 133 182985 279689 110126492
Nasopharyngitis 164.38 10.16 249 182869 394112 110012069
Normochromic normocytic anaemia 164.16 10.16 151 182967 12906 110393275
Bloody discharge 163 10.16 83 183035 2650 110403531
Lower respiratory tract infection 162.14 10.16 101 183017 243005 110163176
Full blood count abnormal 161.65 10.16 314 182804 55738 110350443
Toxic epidermal necrolysis 160.22 10.16 315 182803 56412 110349769
C-reactive protein abnormal 159.94 10.16 15 183103 129680 110276501
Exposure during pregnancy 158.02 10.16 41 183077 167383 110238798
Dysbiosis 157.75 10.16 75 183043 2057 110404124
Clostridium difficile colitis 157.64 10.16 270 182848 43508 110362673
Infusion related reaction 152.83 10.16 247 182871 380915 110025266
Ill-defined disorder 152.72 10.16 36 183082 156817 110249364
Rheumatoid arthritis 150.88 10.16 164 182954 299449 110106732
Total lung capacity abnormal 150.17 10.16 94 183024 4489 110401692
Fibromyalgia 149.99 10.16 48 183070 170861 110235320
Sleep disorder due to general medical condition, insomnia type 148.77 10.16 6 183112 105637 110300544
Intentional overdose 146.91 10.16 22 183096 132479 110273702
Peripheral swelling 145.55 10.16 280 182838 403754 110002427
Neutrophil count decreased 145.37 10.16 486 182632 120455 110285726
Lip dry 143.29 10.16 5 183113 100078 110306103
Respiratory symptom 143.28 10.16 149 182969 14796 110391385
Tendon discomfort 142.94 10.16 49 183069 552 110405629
Type 2 diabetes mellitus 141.58 10.16 58 183060 177174 110229007
Cytokine release syndrome 140.96 10.16 340 182778 69966 110336215
Vascular purpura 140.59 10.16 84 183034 3687 110402494
Obstructive airways disorder 139.81 10.16 264 182854 45885 110360296
Pancytopenia 138.48 10.16 700 182418 208913 110197268
Platelet count decreased 136.74 10.16 747 182371 229696 110176485
Therapeutic product effect decreased 136.52 10.16 122 182996 244194 110161987
Abdominal discomfort 134.96 10.16 281 182837 393577 110012604
Congenital hiatus hernia 134.81 10.16 99 183019 6160 110400021
Productive cough 133.55 10.16 455 182663 113850 110292331
Septic shock 131.25 10.16 563 182555 156965 110249216
Acute kidney injury 130.90 10.16 1617 181501 633813 109772368
Myoclonus 128.79 10.16 211 182907 32787 110373394
Neurological symptom 127.52 10.16 143 182975 15465 110390716
Osteoarthritis 127.22 10.16 72 183046 182551 110223630
Neurotoxicity 126.07 10.16 240 182878 41967 110364214
Headache 125.86 10.16 900 182218 881477 109524704
Contrast media allergy 124.38 10.16 75 183043 3348 110402833
Alopecia 122.64 10.16 263 182855 364490 110041691
Haemoptysis 122.12 10.16 325 182793 71029 110335152
Acute myeloid leukaemia 119.17 10.16 221 182897 37889 110368292
Migraine 117.67 10.16 69 183049 171583 110234598
Bursitis 116.66 10.16 35 183083 129883 110276298
Swelling 116.45 10.16 255 182863 350786 110055395
Lyme disease 115.59 10.16 78 183040 4238 110401943
Pseudomembranous colitis 115.40 10.16 91 183027 6300 110399881
Drug interaction 115.38 10.16 1301 181817 498882 109907299
Toxic skin eruption 112.92 10.16 180 182938 27335 110378846
Lip oedema 111.67 10.16 96 183022 7504 110398677
Dry mouth 111.51 10.16 100 183018 199848 110206333
Obesity 110.37 10.16 26 183092 113325 110292856
Forced expiratory volume decreased 109.85 10.16 122 182996 13054 110393127
Malignant melanoma in situ 109.44 10.16 70 183048 3472 110402709
Computerised tomogram thorax abnormal 108.75 10.16 64 183054 2731 110403450
Contusion 108.56 10.16 136 182982 233225 110172956
Bronchopulmonary aspergillosis 107.28 10.16 184 182934 29679 110376502
Grip strength decreased 105.20 10.16 7 183111 80167 110326014
General physical health deterioration 105.02 10.16 357 182761 424938 109981243
Intentional product use issue 103.74 10.16 156 182962 247750 110158431
Sciatica 103.21 10.16 15 183103 92384 110313797
Contraindicated product administered 102.18 10.16 158 182960 248109 110158072
Injection site pain 101.61 10.16 87 183031 177835 110228346
Loss of employment 100.64 10.16 65 183053 3279 110402902
Joint range of motion decreased 100.37 10.16 38 183080 121794 110284387
Blister 100.15 10.16 138 182980 227238 110178943
Sepsis 98.75 10.16 900 182218 326446 110079735
Vasculitis 98.64 10.16 197 182921 35676 110370505
Hepatitis cholestatic 98.29 10.16 133 182985 17433 110388748
Anaemia 97.83 10.16 1357 181761 545729 109860452
Benign prostatic hyperplasia 97.41 10.16 135 182983 18099 110388082
Clostridium difficile infection 96.98 10.16 245 182873 51884 110354297
Injection site reaction 95.99 10.16 16 183102 89054 110317127
Acute generalised exanthematous pustulosis 94.84 10.16 146 182972 21518 110384663
Hepatic function abnormal 94.43 10.16 344 182774 88951 110317230
Constipation 94.26 10.16 956 182162 356830 110049351
Multiple organ dysfunction syndrome 94.17 10.16 498 182620 151212 110254969
Inflammation 93.71 10.16 109 183009 193129 110213052
Haemophagocytic lymphohistiocytosis 93.69 10.16 179 182939 31380 110374801
Atelectasis 93.13 10.16 195 182923 36517 110369664
Torsade de pointes 91.58 10.16 147 182971 22453 110383728
Antineutrophil cytoplasmic antibody positive 91.06 10.16 72 183046 5004 110401177
Road traffic accident 91.01 10.16 32 183086 107366 110298815
Pneumonitis 89.69 10.16 305 182813 76226 110329955
Computerised tomogram thorax 87.82 10.16 33 183085 493 110405688
Agranulocytosis 86.82 10.16 262 182856 61498 110344683
Affective disorder 86.76 10.16 100 183018 11141 110395040
Disseminated mucormycosis 86.73 10.16 50 183068 2052 110404129
Blood bilirubin increased 86.61 10.16 300 182818 75672 110330509
Hypocoagulable state 86.60 10.16 54 183064 2561 110403620
Injury 85.95 10.16 100 183018 177165 110229016
Hepatic enzyme increased 85.72 10.16 260 182858 320632 110085549
Crystal nephropathy 84.27 10.16 47 183071 1809 110404372
Arteriosclerosis coronary artery 84.04 10.16 150 182968 24968 110381213
Drug abuse 83.97 10.16 102 183016 177309 110228872
Immune reconstitution inflammatory syndrome 83.50 10.16 118 183000 16108 110390073
Wound infection 83.02 10.16 28 183090 96437 110309744
Hepatic cytolysis 82.58 10.16 239 182879 54814 110351367
Delusion of grandeur 80.78 10.16 49 183069 2211 110403970
Suicide attempt 80.69 10.16 35 183083 103359 110302822
Inappropriate schedule of product administration 79.65 10.16 134 182984 203503 110202678
Pneumonia fungal 78.46 10.16 109 183009 14645 110391536
Eosinophilic pneumonia 78.33 10.16 77 183041 7150 110399031
Arteriosclerosis 77.90 10.16 144 182974 24623 110381558
Product dose omission issue 75.45 10.16 276 182842 321506 110084675
Peripheral venous disease 74.90 10.16 23 183095 84094 110322087
Dizziness 73.98 10.16 769 182349 697424 109708757
Fixed eruption 73.72 10.16 59 183059 4173 110402008
Candida infection 73.54 10.16 210 182908 47799 110358382
Hyperbilirubinaemia 73.28 10.16 159 182959 30512 110375669
Purpura 73.22 10.16 139 182979 24249 110381932
Fatigue 71.71 10.16 1503 181615 1214455 109191726
Creatinine renal clearance increased 70.64 10.16 54 183064 3571 110402610
Hypoglycaemia 70.59 10.16 379 182739 115725 110290456
Lower limb fracture 70.04 10.16 19 183099 75329 110330852
Mucosal inflammation 69.83 10.16 330 182788 95811 110310370
Aspartate aminotransferase increased 69.82 10.16 479 182639 159457 110246724
Product quality issue 69.07 10.16 21 183097 77278 110328903
Hepatocellular injury 67.60 10.16 211 182907 50431 110355750
Tubulointerstitial nephritis 66.85 10.16 220 182898 54064 110352117
Prescribed overdose 66.23 10.16 31 183087 87550 110318631
Respiratory muscle weakness 65.25 10.16 25 183093 395 110405786
Product use issue 65.04 10.16 280 182838 311415 110094766
Trimethylaminuria 64.98 10.16 21 183097 194 110405987
Tongue oedema 64.65 10.16 74 183044 8182 110397999
Nail disorder 63.34 10.16 10 183108 57925 110348256
Stress 63.26 10.16 49 183069 105299 110300882
Knee arthroplasty 63.02 10.16 15 183103 64933 110341248
Long QT syndrome 62.97 10.16 68 183050 7050 110399131
Lymphocyte count abnormal 62.96 10.16 43 183075 2383 110403798
Factor V inhibition 62.77 10.16 24 183094 377 110405804
Pregnancy 62.70 10.16 6 183112 51061 110355120
Plasma cell myeloma 61.99 10.16 237 182881 62699 110343482
Blood pressure increased 61.62 10.16 220 182898 258153 110148028
Sinusitis 61.60 10.16 267 182851 296421 110109760
Night sweats 61.34 10.16 79 183039 133904 110272277
Paradoxical drug reaction 60.59 10.16 78 183040 9739 110396442
Mixed liver injury 59.45 10.16 86 183032 11993 110394188
Conjunctival hyperaemia 59.27 10.16 60 183058 5771 110400410
Eosinophilic pneumonia acute 59.26 10.16 36 183082 1629 110404552
Breath sounds abnormal 58.77 10.16 130 182988 25274 110380907
Staphylococcal infection 57.46 10.16 249 182869 69695 110336486
Encephalopathy 57.26 10.16 276 182842 80779 110325402
Hypotension 56.87 10.16 1199 181919 522650 109883531
Blepharospasm 56.62 10.16 11 183107 54840 110351341
Adverse event 56.47 10.16 58 183060 108751 110297430
Drug eruption 56.12 10.16 206 182912 53453 110352728
International normalised ratio increased 56.00 10.16 288 182830 86484 110319697
Coeliac disease 55.99 10.16 4 183114 43183 110362998
Hip arthroplasty 55.94 10.16 12 183106 55801 110350380
Stevens-Johnson syndrome 55.90 10.16 188 182930 46713 110359468
Immune effector cell-associated neurotoxicity syndrome 55.63 10.16 93 183025 14689 110391492
Tracheobronchomegaly 55.16 10.16 12 183106 15 110406166
Back injury 54.58 10.16 7 183111 47392 110358789
Onychomadesis 54.42 10.16 6 183112 45657 110360524
Weight decreased 54.35 10.16 504 182614 467553 109938628
Lymphocyte count decreased 54.29 10.16 213 182905 57030 110349151
Immune reconstitution inflammatory syndrome associated tuberculosis 54.25 10.16 29 183089 1025 110405156
Factor XIII deficiency 53.06 10.16 15 183103 83 110406098
Cerebrovascular accident 52.71 10.16 141 182977 181143 110225038
Colitis ulcerative 51.74 10.16 32 183086 77331 110328850
Arthritis 51.29 10.16 127 182991 167459 110238722
Nodule 51.21 10.16 144 182974 32487 110373694
Tendon injury 51.09 10.16 38 183080 2411 110403770
Respiratory distress 50.45 10.16 237 182881 68637 110337544
Fungaemia 50.13 10.16 56 183062 6030 110400151
Myoclonic dystonia 49.90 10.16 14 183104 75 110406106
Injection site swelling 49.69 10.16 20 183098 61770 110344411
Injection site bruising 49.42 10.16 12 183106 51251 110354930
White blood cell count decreased 49.34 10.16 589 182529 228801 110177380
Capillaritis 49.00 10.16 37 183081 2402 110403779
Cross sensitivity reaction 48.93 10.16 53 183065 5514 110400667
Megacolon 48.78 10.16 47 183071 4258 110401923
Chest pain 48.69 10.16 394 182724 375981 110030200
Rhinalgia 48.54 10.16 45 183073 3884 110402297
Frequent bowel movements 48.48 10.16 29 183089 71361 110334820
Therapeutic response decreased 48.33 10.16 53 183065 96446 110309735
Myalgia 48.27 10.16 572 182546 221809 110184372
Prescribed underdose 47.86 10.16 24 183094 65150 110341031
Hypokalaemia 47.74 10.16 487 182631 181961 110224220
Erythema multiforme 47.72 10.16 107 183011 20990 110385191
Injection site erythema 46.86 10.16 52 183066 94124 110312057
Alanine aminotransferase increased 46.40 10.16 487 182631 183286 110222895
Intentional product misuse 46.15 10.16 94 183024 132810 110273371
Memory impairment 46.09 10.16 169 182949 196775 110209406
Malaise 46.01 10.16 809 182309 671010 109735171
Aortitis 45.96 10.16 33 183085 1982 110404199
Blood pressure fluctuation 45.95 10.16 34 183084 74790 110331391
Drug intolerance 45.78 10.16 441 182677 406071 110000110
Osteoporosis 45.74 10.16 46 183072 87106 110319075
Somnolence 45.40 10.16 297 182821 297152 110109029
Depression 45.39 10.16 323 182795 317012 110089169
Pain 45.18 10.16 1220 181898 953735 109452446
Lupus-like syndrome 44.69 10.16 7 183111 40785 110365396
Liver injury 44.47 10.16 116 183002 150297 110255884
Face oedema 44.26 10.16 139 182979 33330 110372851
Aspergillus infection 44.15 10.16 117 183001 25499 110380682
Drug dependence 43.95 10.16 14 183104 50006 110356175
Exostosis 43.83 10.16 11 183107 45945 110360236
Disseminated intravascular coagulation 43.59 10.16 159 182959 41127 110365054
Acute myeloid leukaemia recurrent 43.56 10.16 48 183070 5091 110401090
Incorrect route of product administration 43.54 10.16 26 183092 64035 110342146
Leukopenia 43.24 10.16 406 182712 148385 110257796
Stomatitis 43.21 10.16 266 182852 269976 110136205
X-ray abnormal 43.01 10.16 6 183112 38111 110368070
Fusarium infection 42.75 10.16 36 183082 2735 110403446
Rash morbilliform 42.67 10.16 59 183059 7892 110398289
Degenerative mitral valve disease 42.24 10.16 17 183101 308 110405873
Accidental exposure to product 42.19 10.16 15 183103 49993 110356188
Acquired macroglossia 41.81 10.16 16 183102 252 110405929
Myocardial infarction 41.62 10.16 170 182948 191913 110214268
Muscle atrophy 41.61 10.16 77 183041 13177 110393004
Renal function test abnormal 41.58 10.16 62 183056 8884 110397297
Underdose 41.52 10.16 27 183091 63527 110342654
Mucormycosis 41.52 10.16 68 183050 10560 110395621
Pneumonia bacterial 41.32 10.16 116 183002 26145 110380036
Dermatitis exfoliative generalised 41.25 10.16 69 183049 10903 110395278
Chronic fatigue syndrome 41.10 10.16 27 183091 1402 110404779
Feeling abnormal 41.03 10.16 157 182961 180554 110225627
Adverse drug reaction 40.76 10.16 70 183048 105489 110300692
Vanishing bile duct syndrome 40.53 10.16 37 183081 3131 110403050
Peripheral sensory neuropathy 40.45 10.16 87 183031 16593 110389588
Leukocytosis 39.99 10.16 186 182932 53642 110352539
Pleural effusion 39.85 10.16 460 182658 177249 110228932
Bronchiectasis 39.77 10.16 142 182976 36351 110369830
Drug-induced liver injury 39.71 10.16 337 182781 119730 110286451
Amnesia 39.71 10.16 71 183047 105337 110300844
Acute respiratory distress syndrome 39.65 10.16 184 182934 53014 110353167
Nervous system disorder 39.45 10.16 129 182989 31592 110374589
Klebsiella infection 39.27 10.16 96 183022 19913 110386268
Obliterative bronchiolitis 39.11 10.16 39 183079 3684 110402497
Bone erosion 38.97 10.16 14 183104 46357 110359824
Streptococcal sepsis 38.94 10.16 45 183073 5027 110401154
Gait inability 38.94 10.16 107 183011 136269 110269912
Autoimmune disorder 38.63 10.16 31 183087 65452 110340729
Symmetrical drug-related intertriginous and flexural exanthema 38.60 10.16 29 183089 1868 110404313
Joint stiffness 38.23 10.16 33 183085 67210 110338971
Enterococcal infection 38.17 10.16 96 183022 20270 110385911
Therapy non-responder 38.12 10.16 133 182985 157174 110249007
Musculoskeletal injury 37.76 10.16 14 183104 201 110405980
Hydrocephalus 37.36 10.16 64 183054 10311 110395870
Rhabdomyolysis 37.25 10.16 333 182785 120068 110286113
Foot deformity 36.90 10.16 17 183101 48463 110357718
Skin reaction 36.87 10.16 97 183021 21047 110385134
Nasal mucosal disorder 36.58 10.16 28 183090 1855 110404326
Meningitis tuberculous 36.40 10.16 24 183094 1254 110404927
Status epilepticus 36.26 10.16 125 182993 31446 110374735
Sleep disorder due to a general medical condition 35.76 10.16 176 182942 51936 110354245
Blast cell count increased 35.50 10.16 26 183092 1611 110404570
Hypoaesthesia 35.31 10.16 341 182777 313882 110092299
Pseudomonas infection 35.30 10.16 114 183004 27739 110378442
Pneumothorax 34.85 10.16 133 182985 35152 110371029
Nail bed inflammation 34.72 10.16 28 183090 2002 110404179
Palatal oedema 34.62 10.16 26 183092 1674 110404507
Early retirement 34.48 10.16 8 183110 16 110406165
Cryopyrin associated periodic syndrome 34.45 10.16 18 183100 607 110405574
Sleep disorder 34.16 10.16 191 182927 198453 110207728
Micturition urgency 34.06 10.16 89 183029 19231 110386950
Optic neuropathy 33.56 10.16 40 183078 4618 110401563
Vertebral artery dissection 33.55 10.16 13 183105 212 110405969
Nocardiosis 33.54 10.16 51 183067 7435 110398746
Muscle contractions involuntary 33.40 10.16 39 183079 4405 110401776
Myasthenia gravis crisis 33.12 10.16 26 183092 1788 110404393
Aortic rupture 32.95 10.16 13 183105 223 110405958
Rectal haemorrhage 32.75 10.16 96 183022 119737 110286444
Bacteraemia 32.61 10.16 148 182970 42242 110363939
Haematoma muscle 32.60 10.16 37 183081 4053 110402128
Cystic fibrosis pancreatic 32.60 10.16 9 183109 45 110406136
Therapeutic response shortened 32.58 10.16 5 183113 29578 110376603
Dysentery 32.53 10.16 23 183095 1348 110404833
Multiple drug therapy 32.29 10.16 52 183066 7962 110398219
Stenotrophomonas infection 32.23 10.16 44 183074 5814 110400367
Dyspnoea 32.20 10.16 2185 180933 1104687 109301494
Hypothyroidism 32.19 10.16 219 182899 72680 110333501
Arthralgia 32.06 10.16 1015 182103 778617 109627564
Gastritis fungal 31.96 10.16 14 183104 316 110405865
Gamma-glutamyltransferase increased 31.89 10.16 192 182926 61117 110345064
Abdominal pain 31.89 10.16 628 182490 512361 109893820
Drug tolerance decreased 31.87 10.16 4 183114 27536 110378645
Kounis syndrome 31.85 10.16 44 183074 5881 110400300
Septic embolus 31.40 10.16 28 183090 2298 110403883
Clostridial infection 31.21 10.16 45 183073 6257 110399924
Enterocolitis 31.10 10.16 85 183033 18864 110387317
Wrong technique in product usage process 30.99 10.16 61 183057 87287 110318894
Renal failure 30.82 10.16 537 182581 226037 110180144
Blood alkaline phosphatase increased 30.67 10.16 212 182906 70723 110335458
Lupus vulgaris 30.64 10.16 9 183109 33874 110372307
Chorea 30.56 10.16 32 183086 3203 110402978
Taste disorder 30.50 10.16 38 183080 65349 110340832
Cardiogenic shock 30.39 10.16 30 183088 57308 110348873
Idiopathic orbital inflammation 30.24 10.16 14 183104 361 110405820
Aminoaciduria 30.20 10.16 14 183104 362 110405819
Acute febrile neutrophilic dermatosis 30.12 10.16 39 183079 4897 110401284
Hypoglycaemic coma 29.60 10.16 41 183077 5492 110400689
Injection site pruritus 29.33 10.16 25 183093 51233 110354948
Red blood cell sedimentation rate increased 29.26 10.16 53 183065 78249 110327932
Collagen disorder 29.25 10.16 13 183105 304 110405877
Infective pulmonary exacerbation of cystic fibrosis 29.13 10.16 71 183047 14700 110391481
Tuberculoma of central nervous system 29.04 10.16 16 183102 601 110405580
Normocytic anaemia 28.89 10.16 44 183074 6423 110399758
Toxic encephalopathy 28.81 10.16 72 183046 15142 110391039
Trichoglossia 28.71 10.16 18 183100 862 110405319
Multiple-drug resistance 28.68 10.16 66 183052 13169 110393012
Laryngeal oedema 28.34 10.16 55 183063 9752 110396429
Musculoskeletal pain 28.29 10.16 182 182936 182841 110223340
Suicidal ideation 28.10 10.16 72 183046 93865 110312316
Pulmonary embolism 27.99 10.16 505 182613 213969 110192212
Keratopathy 27.96 10.16 21 183097 1352 110404829
Premature delivery 27.95 10.16 8 183110 30624 110375557
Poisoning 27.69 10.16 7 183111 29098 110377083
Bronchostenosis 27.66 10.16 18 183100 920 110405261
Product substitution issue 27.56 10.16 3 183115 23058 110383123
Cholangitis 27.53 10.16 74 183044 16261 110389920
Abdominal pain upper 27.30 10.16 410 182708 348701 110057480
Linear IgA disease 27.29 10.16 35 183083 4354 110401827
Dermatitis bullous 27.16 10.16 77 183041 17452 110388729
Candida endophthalmitis 27.14 10.16 11 183107 203 110405978
Blood lactate dehydrogenase increased 27.12 10.16 145 182973 44189 110361992
Polyneuropathy 27.09 10.16 115 183003 31897 110374284
Chronic pigmented purpura 26.94 10.16 12 183106 282 110405899
Pneumothorax spontaneous 26.79 10.16 23 183095 1794 110404387
Complex regional pain syndrome 26.77 10.16 26 183092 2379 110403802
Hyperuricaemia 26.71 10.16 68 183050 14463 110391718
Ear infection 26.68 10.16 39 183079 62693 110343488
Ventricular enlargement 26.66 10.16 16 183102 708 110405473
Ulcerative keratitis 26.53 10.16 36 183082 4730 110401451
Respiratory tract infection fungal 26.41 10.16 20 183098 1304 110404877
Laryngitis 26.40 10.16 19 183099 42392 110363789
Japanese spotted fever 26.23 10.16 7 183111 30 110406151
Renal tubular necrosis 26.19 10.16 110 183008 30365 110375816
Seizure 26.17 10.16 513 182605 220672 110185509
Ballismus 26.15 10.16 12 183106 303 110405878
Oliguria 26.07 10.16 79 183039 18578 110387603
Psoriasis 26.07 10.16 131 182987 139862 110266319
Systemic inflammatory response syndrome 26.05 10.16 63 183055 12980 110393201
Dyspepsia 26.03 10.16 197 182921 190768 110215413
Diabetic ketoacidosis 25.97 10.16 19 183099 42039 110364142
Hallucination, visual 25.93 10.16 132 182986 39473 110366708
Geotrichum infection 25.72 10.16 19 183099 1193 110404988
Henoch-Schonlein purpura 25.68 10.16 31 183087 3626 110402555
Ectropion 25.65 10.16 14 183104 516 110405665
Infection in an immunocompromised host 25.62 10.16 23 183095 1904 110404277
Pneumocystis jirovecii pneumonia 25.62 10.16 139 182979 42596 110363585
Weber tuning fork test abnormal 25.59 10.16 9 183109 110 110406071
Jaundice 25.59 10.16 177 182941 59059 110347122
Lateral medullary syndrome 25.55 10.16 8 183110 66 110406115
Pulmonary vascular disorder 25.49 10.16 18 183100 1053 110405128
Skin hyperpigmentation 25.41 10.16 49 183069 8647 110397534
Hepatotoxicity 25.39 10.16 186 182932 63214 110342967
Muscle rupture 25.30 10.16 34 183084 4426 110401755
Therapy partial responder 25.24 10.16 15 183103 37046 110369135
Muscle spasticity 25.23 10.16 14 183104 35901 110370280
Type I hypersensitivity 25.11 10.16 41 183077 6352 110399829
Tracheal oedema 24.94 10.16 8 183110 72 110406109
Muscle spasms 24.84 10.16 318 182800 277839 110128342
Connective tissue disorder 24.83 10.16 22 183096 1790 110404391
Neck pain 24.81 10.16 112 183006 123018 110283163
Disorientation 24.77 10.16 201 182917 70470 110335711
Inferior vena cava dilatation 24.76 10.16 17 183101 950 110405231
Device malfunction 24.60 10.16 6 183112 25552 110380629
Sense of oppression 24.58 10.16 21 183097 1627 110404554
Blood pressure systolic increased 24.53 10.16 64 183054 82927 110323254
Coma 24.49 10.16 106 183012 117763 110288418
Delirium 24.48 10.16 336 182782 134689 110271492
Purpura fulminans 24.47 10.16 12 183106 353 110405828
Bradycardia 24.37 10.16 154 182964 155363 110250818
Upper respiratory tract inflammation 24.31 10.16 33 183085 4338 110401843
Weight bearing difficulty 24.10 10.16 30 183088 3621 110402560
Bronchitis chronic 24.06 10.16 35 183083 4905 110401276
Hypersensitivity vasculitis 23.94 10.16 42 183076 6895 110399286
Muscle tension dysphonia 23.85 10.16 11 183107 281 110405900
COVID-19 pneumonia 23.77 10.16 123 182995 37020 110369161
Cystic fibrosis 23.75 10.16 34 183084 4697 110401484
Ecthyma 23.66 10.16 17 183101 1022 110405159
Vitreous opacities 23.65 10.16 16 183102 873 110405308
Basal cell carcinoma 23.63 10.16 24 183094 45246 110360935
Anterior chamber flare 23.58 10.16 10 183108 208 110405973
Heart rate decreased 23.57 10.16 65 183053 82691 110323490
Feeling hot 23.46 10.16 75 183043 91031 110315150
Normal newborn 23.44 10.16 4 183114 21892 110384289
Rheumatoid nodule 23.36 10.16 3 183115 20293 110385888
Thrombosis 23.34 10.16 279 182839 108383 110297798
Tubulointerstitial nephritis and uveitis syndrome 23.26 10.16 12 183106 394 110405787
Transaminases increased 23.15 10.16 182 182936 63208 110342973
Band sensation 23.10 10.16 17 183101 1061 110405120
Neutrophil count increased 23.04 10.16 116 183002 34536 110371645
Hyperpyrexia 23.01 10.16 45 183073 8024 110398157
Influenza B virus test positive 22.77 10.16 12 183106 412 110405769
Paraspinal abscess 22.71 10.16 12 183106 414 110405767
Endophthalmitis 22.55 10.16 45 183073 8142 110398039
Painful ejaculation 22.51 10.16 8 183110 101 110406080
Overdose 22.49 10.16 263 182855 233531 110172650
Occult blood 22.43 10.16 21 183097 1835 110404346
Demodicidosis 22.42 10.16 10 183108 236 110405945
Glaucoma 22.34 10.16 85 183033 22432 110383749
Ulcer haemorrhage 22.32 10.16 5 183113 22566 110383615
Haematotoxicity 22.09 10.16 81 183037 21001 110385180
Liver function test increased 22.04 10.16 74 183044 88474 110317707
Nicotine dependence 22.01 10.16 18 183100 1313 110404868
Radiculopathy 21.92 10.16 3 183115 19333 110386848
Respiratory syncytial virus infection 21.83 10.16 63 183055 14421 110391760
Mechanical urticaria 21.77 10.16 13 183105 570 110405611
Prostate tenderness 21.72 10.16 7 183111 64 110406117
Arteritis infective 21.68 10.16 9 183109 177 110406004
Angioedema 21.64 10.16 254 182864 98246 110307935
Sleep apnoea syndrome 21.62 10.16 21 183097 40426 110365755
Anti-neutrophil cytoplasmic antibody positive vasculitis 21.62 10.16 35 183083 5382 110400799
Sebaceous adenitis 21.62 10.16 4 183114 0 110406181
Haemolytic anaemia 21.61 10.16 80 183038 20840 110385341
Cardiac aneurysm 21.58 10.16 20 183098 1725 110404456
Pneumonia legionella 21.47 10.16 28 183090 3541 110402640
Hypoalbuminaemia 21.43 10.16 100 183018 28874 110377307
Pneumonia pseudomonal 21.42 10.16 42 183076 7504 110398677
Haematoma 21.42 10.16 168 182950 58308 110347873
Accidental overdose 21.29 10.16 33 183085 51801 110354380
Osteonecrosis of jaw 21.27 10.16 29 183089 47988 110358193
Drug withdrawal syndrome 21.24 10.16 19 183099 38035 110368146
Ulcer 21.24 10.16 24 183094 43092 110363089
Macular degeneration 21.02 10.16 5 183113 21654 110384527
Withdrawal syndrome 20.95 10.16 13 183105 31367 110374814
Blood creatinine increased 20.90 10.16 422 182696 182467 110223714
Diabetes mellitus 20.87 10.16 89 183029 99292 110306889
Ear pain 20.82 10.16 35 183083 53191 110352990
Device issue 20.81 10.16 16 183102 34519 110371662
Multiple sclerosis relapse 20.62 10.16 32 183086 50208 110355973
Bilirubin conjugated increased 20.60 10.16 37 183081 6187 110399994
Intentional self-injury 20.52 10.16 19 183099 37410 110368771
Phlebosclerosis 20.51 10.16 8 183110 133 110406048
Haematochezia 20.44 10.16 110 183008 115414 110290767
Respiratory arrest 20.43 10.16 41 183077 58258 110347923
Vascular device infection 20.40 10.16 67 183051 16445 110389736
Thrombotic microangiopathy 20.39 10.16 99 183019 29050 110377131
Renal arteriosclerosis 20.39 10.16 12 183106 512 110405669
Chronic obstructive pulmonary disease 20.35 10.16 273 182845 108885 110297296
No adverse event 20.29 10.16 59 183059 73780 110332401
Conductive deafness 20.27 10.16 10 183108 298 110405883
Axonal neuropathy 20.25 10.16 22 183096 2296 110403885
Cytopenia 20.16 10.16 101 183017 30015 110376166
Erythema 20.05 10.16 628 182490 290819 110115362
Skin haemorrhage 20.02 10.16 8 183110 24819 110381362
Toxic optic neuropathy 19.97 10.16 17 183101 1311 110404870
Drug ineffective for unapproved indication 19.92 10.16 259 182859 102579 110303602
Tumour associated fever 19.83 10.16 16 183102 1145 110405036
Cutaneous vasculitis 19.80 10.16 56 183062 12673 110393508
Bicytopenia 19.78 10.16 38 183080 6686 110399495
Keratic precipitates 19.73 10.16 12 183106 544 110405637
Escherichia infection 19.72 10.16 85 183033 23731 110382450
Pulmonary renal syndrome 19.70 10.16 14 183104 827 110405354
Helicobacter test positive 19.69 10.16 17 183101 1336 110404845
Small fibre neuropathy 19.67 10.16 15 183103 988 110405193
Skin erosion 19.63 10.16 35 183083 5819 110400362
Ultrasound foetal abnormal 19.58 10.16 7 183111 90 110406091
Breast cancer 19.48 10.16 21 183097 38521 110367660
Fluid retention 19.47 10.16 85 183033 94222 110311959
Nasal congestion 19.44 10.16 90 183028 98192 110307989
Hepatic cirrhosis 19.34 10.16 53 183065 67573 110338608
Nephrogenic diabetes insipidus 19.29 10.16 22 183096 2423 110403758
Cystitis haemorrhagic 19.27 10.16 54 183064 12155 110394026
Abortion spontaneous 19.27 10.16 17 183101 34265 110371916
Corneal oedema 19.25 10.16 25 183093 3148 110403033
Prurigo 19.19 10.16 17 183101 1383 110404798
Bronchitis 19.18 10.16 366 182752 156666 110249515
Enterocolitis bacterial 19.07 10.16 13 183105 718 110405463
Functional residual capacity increased 19.04 10.16 7 183111 98 110406083
Diabetic bullosis 19.01 10.16 5 183113 20 110406161
Ligament pain 18.99 10.16 9 183109 245 110405936
Boutonneuse fever 18.85 10.16 4 183114 4 110406177
Corneal opacity 18.78 10.16 16 183102 1235 110404946
Dry skin 18.78 10.16 103 183015 107550 110298631
Corneal erosion 18.72 10.16 11 183107 468 110405713
Gastrooesophageal reflux disease 18.68 10.16 199 182919 179777 110226404
Haemarthrosis 18.67 10.16 39 183079 7290 110398891
Cough 18.66 10.16 939 182179 460702 109945479
Altered state of consciousness 18.65 10.16 161 182957 57465 110348716
FEV1/FVC ratio abnormal 18.61 10.16 6 183112 55 110406126
Supraventricular tachycardia 18.59 10.16 85 183033 24337 110381844
Acinetobacter infection 18.41 10.16 26 183092 3547 110402634
Acute respiratory failure 18.31 10.16 198 182920 75062 110331119
Sensory level abnormal 18.28 10.16 8 183110 180 110406001
Cytokine storm 18.28 10.16 17 183101 1473 110404708
Product dose omission in error 18.28 10.16 8 183110 23504 110382677
Strongyloidiasis 18.27 10.16 31 183087 4955 110401226
Injection site mass 18.17 10.16 9 183109 24604 110381577
Unmasking of previously unidentified disease 18.03 10.16 23 183095 2845 110403336
Incision site pain 17.94 10.16 24 183094 3111 110403070
Lactobacillus infection 17.88 10.16 11 183107 509 110405672
Confabulation 17.86 10.16 11 183107 510 110405671
Fat tissue decreased 17.85 10.16 8 183110 191 110405990
Medication error 17.73 10.16 102 183016 105264 110300917
Graft versus host disease in skin 17.71 10.16 41 183077 8213 110397968
Respiratory alkalosis 17.66 10.16 33 183085 5688 110400493
Capillary permeability increased 17.63 10.16 6 183112 66 110406115
Foreign body aspiration 17.60 10.16 11 183107 524 110405657
Cramp-fasciculation syndrome 17.59 10.16 4 183114 7 110406174
Graft versus host disease in gastrointestinal tract 17.57 10.16 43 183075 8925 110397256
Visual acuity reduced 17.53 10.16 102 183016 32071 110374110
Hypersensitivity 17.53 10.16 522 182596 403476 110002705
Guillain-Barre syndrome 17.44 10.16 48 183070 10696 110395485
Time perception altered 17.43 10.16 8 183110 202 110405979
Lacunar stroke 17.30 10.16 11 183107 540 110405641
Therapy naive 17.24 10.16 6 183112 71 110406110
Liver abscess 17.22 10.16 39 183079 7700 110398481
Gallbladder empyema 17.18 10.16 7 183111 131 110406050
Jarisch-Herxheimer reaction 17.13 10.16 15 183103 1202 110404979
Ciliary hyperaemia 17.09 10.16 6 183112 73 110406108
Hypertension 17.06 10.16 681 182437 509403 109896778
Device difficult to use 17.00 10.16 5 183113 18800 110387381
Duodenitis 16.87 10.16 43 183075 9153 110397028
Abdominal distension 16.83 10.16 197 182921 174906 110231275
Renal ischaemia 16.82 10.16 20 183098 2303 110403878
Enteritis infectious 16.76 10.16 26 183092 3856 110402325
SJS-TEN overlap 16.75 10.16 18 183100 1856 110404325
Corneal exfoliation 16.63 10.16 4 183114 10 110406171
Hallucination, auditory 16.60 10.16 87 183031 26310 110379871
Osteopenia 16.57 10.16 8 183110 22201 110383980
Secretion discharge 16.57 10.16 72 183046 20172 110386009
Factor XIII Inhibition 16.57 10.16 5 183113 36 110406145
Sputum purulent 16.56 10.16 18 183100 1880 110404301
Dermatitis atopic 16.48 10.16 11 183107 25530 110380651
Device related infection 16.43 10.16 117 183001 39402 110366779
Bacterial sepsis 16.35 10.16 46 183072 10380 110395801
Hypercholesterolaemia 16.35 10.16 86 183032 90751 110315430
Hepatitis B e antigen positive 16.33 10.16 5 183113 38 110406143
Skin exfoliation 16.25 10.16 219 182899 87432 110318749
Tonsillitis bacterial 16.20 10.16 8 183110 239 110405942
Heart rate increased 16.18 10.16 156 182962 143678 110262503
Petechiae 16.17 10.16 79 183039 23238 110382943
Generalised onset non-motor seizure 16.13 10.16 6 183112 87 110406094
SARS-CoV-2 test positive 16.04 10.16 63 183055 16872 110389309
Herpes dermatitis 16.03 10.16 9 183109 351 110405830
Aplastic anaemia 15.90 10.16 81 183037 24227 110381954
Joint dislocation 15.81 10.16 20 183098 34170 110372011
Vaginal discharge 15.75 10.16 5 183113 17903 110388278
Therapeutic response unexpected 15.75 10.16 10 183108 23833 110382348
Tumour lysis syndrome 15.73 10.16 96 183022 30705 110375476
Angular cheilitis 15.72 10.16 14 183104 1147 110405034
Injection site haemorrhage 15.61 10.16 19 183099 33009 110373172
H1N1 influenza 15.61 10.16 22 183096 2996 110403185
Long QT syndrome congenital 15.58 10.16 7 183111 168 110406013
Blood pressure diastolic abnormal 15.50 10.16 12 183106 25803 110380378
Dystonia 15.49 10.16 12 183106 25793 110380388
Graft versus host disease 15.48 10.16 67 183051 18739 110387442
Differentiation syndrome 15.46 10.16 22 183096 3022 110403159
Interstitial lung disease 15.42 10.16 320 182798 139014 110267167
Forearm fracture 15.36 10.16 11 183107 658 110405523
Psychotic disorder 15.30 10.16 140 182978 50797 110355384
Urinary tract inflammation 15.19 10.16 9 183109 389 110405792
Escherichia bacteraemia 15.12 10.16 44 183074 10120 110396061
Subacute endocarditis 15.10 10.16 7 183111 181 110406000
Food intolerance 15.10 10.16 27 183091 4500 110401681
Peripheral sensorimotor neuropathy 15.10 10.16 25 183093 3918 110402263
Tuberculosis of central nervous system 15.09 10.16 10 183108 527 110405654
Lip erosion 15.08 10.16 17 183101 1849 110404332
Injection site warmth 15.06 10.16 5 183113 17400 110388781
Intestinal obstruction 15.01 10.16 42 183076 53185 110352996
Cell death 14.97 10.16 31 183087 5760 110400421
Urinary tract infection enterococcal 14.89 10.16 24 183094 3678 110402503
Asthma 14.83 10.16 530 182588 249761 110156420
Haemorrhagic pneumonia 14.82 10.16 7 183111 189 110405992
Irritability 14.80 10.16 36 183082 47773 110358408
Drug dose omission by device 14.80 10.16 3 183115 14513 110391668
Pulmonary haemorrhage 14.61 10.16 60 183058 16396 110389785
Circumoral oedema 14.43 10.16 9 183109 427 110405754
Insomnia 14.41 10.16 471 182647 360119 110046062
Hallucination 14.36 10.16 242 182876 101190 110304991
Arthritis fungal 14.33 10.16 7 183111 204 110405977
Sinusitis fungal 14.32 10.16 20 183098 2700 110403481
Phrenic nerve paralysis 14.28 10.16 10 183108 577 110405604
Renal necrosis 14.27 10.16 8 183110 311 110405870
Multiple sclerosis 14.14 10.16 13 183105 25685 110380496
Amoebic colitis 14.09 10.16 6 183112 126 110406055
Perineal pain 14.09 10.16 15 183103 1530 110404651
Renal impairment 14.01 10.16 410 182708 188035 110218146
Disseminated strongyloidiasis 13.95 10.16 10 183108 599 110405582
Walking disability 13.93 10.16 19 183099 2509 110403672
Injection site rash 13.92 10.16 11 183107 23408 110382773
Anterior chamber inflammation 13.92 10.16 11 183107 764 110405417
Corneal perforation 13.89 10.16 12 183106 944 110405237
Legionella infection 13.89 10.16 12 183106 944 110405237
Hyposmia 13.87 10.16 13 183105 1138 110405043
Joint noise 13.84 10.16 28 183090 5115 110401066
Bronchial obstruction 13.83 10.16 21 183097 3058 110403123
Fat necrosis 13.83 10.16 12 183106 950 110405231
Rhinovirus infection 13.82 10.16 47 183071 11742 110394439
Odynophagia 13.80 10.16 53 183065 14048 110392133
Tachypnoea 13.78 10.16 112 183006 39283 110366898
CD4/CD8 ratio decreased 13.73 10.16 5 183113 68 110406113
Sudden death 13.72 10.16 78 183040 24317 110381864
Product name confusion 13.70 10.16 7 183111 225 110405956
Food allergy 13.69 10.16 8 183110 19940 110386241
Epidermolysis 13.61 10.16 13 183105 1165 110405016
Trunk injury 13.60 10.16 4 183114 26 110406155
Coordination abnormal 13.60 10.16 13 183105 25215 110380966
Acute sinusitis 13.59 10.16 28 183090 5183 110400998
Recall phenomenon 13.53 10.16 14 183104 1382 110404799
Sensory disturbance 13.52 10.16 61 183057 17368 110388813
Organising pneumonia 13.50 10.16 53 183065 14190 110391991
Immunisation reaction 13.50 10.16 11 183107 798 110405383
Splenic vein thrombosis 13.48 10.16 12 183106 983 110405198
Brain oedema 13.48 10.16 93 183025 31005 110375176
Electrocardiogram T wave biphasic 13.45 10.16 7 183111 234 110405947
Body temperature increased 13.42 10.16 46 183072 54667 110351514
Procedural pain 13.35 10.16 24 183094 35541 110370640
Mitochondrial enzyme deficiency 13.35 10.16 4 183114 28 110406153
Acquired haemophilia 13.34 10.16 19 183099 2612 110403569
Polyglandular disorder 13.32 10.16 7 183111 239 110405942
Varicose vein 13.30 10.16 33 183085 6907 110399274
Retinal pigment epithelial tear 13.30 10.16 9 183109 491 110405690
Respiratory tract congestion 13.30 10.16 19 183099 30838 110375343
Therapeutic product effect incomplete 13.28 10.16 474 182644 223331 110182850
Intracranial pressure increased 13.24 10.16 43 183075 10492 110395689
Hyperamylasaemia 13.22 10.16 13 183105 1208 110404973
Bone density decreased 13.21 10.16 5 183113 16037 110390144
Product administration error 13.19 10.16 26 183092 37191 110368990
Herpes simplex viraemia 13.11 10.16 10 183108 659 110405522
Treatment failure 13.09 10.16 354 182764 276880 110129301
Rhinorrhoea 13.01 10.16 108 183010 102558 110303623
Testicular pain 13.00 10.16 18 183100 2411 110403770
Hyperhidrosis 12.95 10.16 225 182893 187073 110219108
Cardiac murmur 12.92 10.16 13 183105 24615 110381566
Cataract subcapsular 12.86 10.16 13 183105 1248 110404933
Exposure via skin contact 12.83 10.16 3 183115 13144 110393037
Myosclerosis 12.78 10.16 7 183111 260 110405921
Neuroleptic malignant syndrome 12.77 10.16 23 183095 34036 110372145
Second primary malignancy 12.75 10.16 7 183111 18061 110388120
Hot flush 12.75 10.16 61 183057 65975 110340206
Glomerulonephritis rapidly progressive 12.74 10.16 17 183101 2198 110403983
Botulism 12.72 10.16 9 183109 528 110405653
Vitamin K decreased 12.71 10.16 5 183113 85 110406096
Haematospermia 12.68 10.16 7 183111 264 110405917
Cytomegalovirus infection 12.68 10.16 142 182976 54302 110351879
Oral pruritus 12.64 10.16 21 183097 3299 110402882
Malabsorption from administration site 12.64 10.16 6 183112 164 110406017
Diplopia 12.62 10.16 32 183086 41862 110364319
Femur fracture 12.61 10.16 35 183083 44434 110361747
Hepatic steatosis 12.60 10.16 130 182988 48701 110357480
Dermatitis 12.51 10.16 84 183034 27753 110378428
HIV infection 12.51 10.16 13 183105 1290 110404891
Bacterial toxaemia 12.51 10.16 6 183112 168 110406013
Atrioventricular block first degree 12.46 10.16 4 183114 14221 110391960
Generalised tonic-clonic seizure 12.45 10.16 142 182976 54538 110351643
Mental status changes 12.43 10.16 186 182932 75936 110330245
Eye pruritus 12.41 10.16 22 183096 32753 110373428
Iron deficiency 12.39 10.16 62 183056 18414 110387767
Adrenal cortex necrosis 12.37 10.16 4 183114 37 110406144
Temperature regulation disorder 12.37 10.16 3 183115 12823 110393358
Ventricular tachycardia 12.36 10.16 132 182986 49877 110356304
Restlessness 12.32 10.16 145 182973 56114 110350067
Walking aid user 12.30 10.16 14 183104 25061 110381120
Gastric cyst 12.30 10.16 5 183113 93 110406088
Platelet count increased 12.16 10.16 80 183038 26254 110379927
Thalamic infarction 12.11 10.16 13 183105 1339 110404842
Pneumococcal infection 12.09 10.16 15 183103 1804 110404377
Chorioretinal disorder 12.09 10.16 6 183112 181 110406000
Perihepatic discomfort 12.07 10.16 3 183115 9 110406172
Aortic aneurysm 12.07 10.16 40 183078 9864 110396317
Orbital infection 12.03 10.16 6 183112 183 110405998
Cholestatic liver injury 12.02 10.16 33 183085 7343 110398838
Cytomegalovirus test positive 11.98 10.16 32 183086 7004 110399177
Product storage error 11.95 10.16 11 183107 21717 110384464
Keratitis fungal 11.91 10.16 8 183110 431 110405750
Systemic candida 11.90 10.16 40 183078 9934 110396247
Systolic dysfunction 11.84 10.16 24 183094 4391 110401790
Device breakage 11.84 10.16 4 183114 13765 110392416
Antibiotic associated colitis 11.83 10.16 3 183115 10 110406171
Bronchial haemorrhage 11.83 10.16 13 183105 1374 110404807
Dysarthria 11.83 10.16 86 183032 84035 110322146
Interleukin level increased 11.81 10.16 14 183104 1607 110404574
Excessive eye blinking 11.76 10.16 15 183103 1855 110404326
Pupillary block 11.75 10.16 4 183114 44 110406137
Nephrolithiasis 11.74 10.16 63 183055 66149 110340032
Rotator cuff syndrome 11.72 10.16 57 183061 16737 110389444
Spinal cord haematoma 11.72 10.16 7 183111 307 110405874
Systemic mycosis 11.71 10.16 22 183096 3807 110402374
Persistent corneal epithelial defect 11.70 10.16 5 183113 106 110406075
Substance-induced psychotic disorder 11.70 10.16 27 183091 5397 110400784
Hypomagnesaemia 11.67 10.16 152 182966 60218 110345963
Respiratory depression 11.65 10.16 22 183096 31979 110374202
Chronic kidney disease 11.53 10.16 184 182934 76107 110330074
Pseudoaldosteronism 11.48 10.16 7 183111 319 110405862
Neoplasm malignant 11.47 10.16 28 183090 37115 110369066
Sensory processing disorder 11.44 10.16 4 183114 48 110406133
Pseudomonal sepsis 11.44 10.16 37 183081 9009 110397172
Dysphonia 11.43 10.16 183 182935 75746 110330435
Hypogeusia 11.39 10.16 16 183102 2171 110404010
Device dislocation 11.37 10.16 22 183096 31682 110374499
Paraesthesia 11.32 10.16 360 182758 276161 110130020
Parkinsonism 11.31 10.16 12 183106 22175 110384006
Pseudolymphoma 11.28 10.16 12 183106 1223 110404958
Skin lesion 11.27 10.16 133 182985 51498 110354683
Head discomfort 11.20 10.16 9 183109 18991 110387190
Hepatitis toxic 11.19 10.16 28 183090 5893 110400288
Prostate cancer 11.14 10.16 29 183089 37612 110368569
Rash erythematous 11.13 10.16 194 182924 81638 110324543
Postural tremor 11.10 10.16 11 183107 1031 110405150
Tachycardia 11.08 10.16 470 182648 226175 110180006
Staphylococcus test positive 11.05 10.16 32 183086 7338 110398843
Pudendal canal syndrome 11.04 10.16 3 183115 14 110406167
Skin cancer 11.02 10.16 8 183110 17776 110388405
Tooth fracture 11.02 10.16 4 183114 13163 110393018
Blood pressure systolic abnormal 11.01 10.16 15 183103 24835 110381346
Haemolytic uraemic syndrome 10.96 10.16 25 183093 4960 110401221
Joint microhaemorrhage 10.95 10.16 4 183114 55 110406126
Lower respiratory tract infection fungal 10.95 10.16 10 183108 847 110405334
Illusion 10.93 10.16 15 183103 1992 110404189
Rhodococcus infection 10.89 10.16 8 183110 498 110405683
Blood urea increased 10.89 10.16 139 182979 54818 110351363
Polymerase chain reaction positive 10.88 10.16 7 183111 351 110405830
Brief psychotic disorder with marked stressors 10.84 10.16 7 183111 353 110405828
Mast cell activation syndrome 10.81 10.16 13 183105 1515 110404666
Gluten sensitivity 10.79 10.16 8 183110 505 110405676
Sneezing 10.78 10.16 23 183095 31961 110374220
Affect lability 10.77 10.16 9 183109 18628 110387553
Corneal infiltrates 10.73 10.16 7 183111 359 110405822
Glycosylated haemoglobin increased 10.73 10.16 14 183104 23605 110382576
Hyperaemia 10.71 10.16 21 183097 3752 110402429
Corneal disorder 10.67 10.16 17 183101 2580 110403601
Haematuria 10.66 10.16 195 182923 82810 110323371
Sputum discoloured 10.63 10.16 81 183037 27864 110378317
Gangrene 10.60 10.16 7 183111 16334 110389847
Anaemia folate deficiency 10.59 10.16 9 183109 692 110405489
Eosinophilic pleural effusion 10.59 10.16 8 183110 520 110405661
Oesophageal oedema 10.57 10.16 4 183114 61 110406120
Hypothermia 10.56 10.16 17 183101 26285 110379896
Eye abscess 10.56 10.16 7 183111 369 110405812
Hepatitis acute 10.56 10.16 60 183058 18706 110387475
Motor dysfunction 10.55 10.16 15 183103 24391 110381790
Respiratory gas exchange disorder 10.55 10.16 10 183108 888 110405293
Hypovolaemic shock 10.54 10.16 50 183068 14533 110391648
Hypertensive crisis 10.51 10.16 15 183103 24357 110381824
Enterococcal bacteraemia 10.51 10.16 23 183095 4438 110401743
Product complaint 10.48 10.16 5 183113 13967 110392214
Prostatitis 10.47 10.16 24 183094 4777 110401404
Strangury 10.43 10.16 6 183112 245 110405936
Endocrine disorder 10.41 10.16 11 183107 1113 110405068
Retinal haemorrhage 10.38 10.16 37 183081 9464 110396717
Mental disorder 10.35 10.16 104 183014 38687 110367494
Injection site urticaria 10.34 10.16 8 183110 17207 110388974
Influenza like illness 10.32 10.16 95 183023 88317 110317864
Oesophagitis ulcerative 10.30 10.16 13 183105 1592 110404589
Post-depletion B-cell recovery 10.27 10.16 3 183115 19 110406162
Loss of personal independence in daily activities 10.24 10.16 323 182795 149697 110256484
Colour blindness acquired 10.23 10.16 5 183113 146 110406035
Respiratory tract infection 10.18 10.16 171 182947 71446 110334735
Optic neuritis 10.18 10.16 41 183077 11106 110395075

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BD10 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
ATC J01MA12 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Fluoroquinolones
ATC J01RA05 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
ATC J04AM12 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
ATC S01AE05 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Fluoroquinolones
FDA CS M0372253 Fluoroquinolones
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000892 Anti-Infective Agents, Urinary
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D065609 Cytochrome P-450 CYP1A2 Inhibitors
FDA EPC N0000193223 Fluoroquinolone Antibacterial
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:50750 EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
CHEBI has role CHEBI:53559 topoisomerase IV inhibitor
CHEBI has role CHEBI:59517 DNA synthesis inhibitor

Related Drugs by ATC class:

A02BD Combinations for eradication of Helicobacter pylori 13 drugs
amoxicillinbismuth subcitrateclarithromycinesomeprazolelansoprazolemetronidazoleomeprazolepantoprazolerabeprazolerifabutintetracyclinetinidazole show all 13 →
J01MA Fluoroquinolones 22 drugs
ciprofloxacindelafloxacinenoxacinfleroxacingarenoxacingatifloxacingemifloxacingrepafloxacinlascufloxacinlomefloxacinmoxifloxacinnorfloxacin show all 22 →
J01RA Combinations of antibacterials 18 drugs
amikacinazithromycincefepimecefiximecefuroximeciprofloxacinfluconazolemetronidazolenitazoxanidenorfloxacinnystatinofloxacin show all 18 →
J04AM Combinations of drugs for treatment of tuberculosis 11 drugs
ethambutolisoniazidlomefloxacinprotionamidepyrazinamiderifabutinrifampicinstreptomycinsulfamethoxazolethioacetazonetrimethoprim
S01AE Fluoroquinolones 8 drugs
besifloxacinciprofloxacingatifloxacinlomefloxacinmoxifloxacinnorfloxacinofloxacintosufloxacin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Otitis media caused by Pseudomonas aeruginosa indication 16664009
Haemophilus Influenzae Acute Otitis Media indication 19021002
Infection of skin AND/OR subcutaneous tissue indication 19824006
Staphylococcal pneumonia indication 22754005
Pneumonia due to Streptococcus indication 34020007
Pyelonephritis indication 45816000 DOID:11400
Pneumonia due to Mycoplasma pneumoniae indication 46970008
Bacterial pneumonia indication 53084003 DOID:874
Klebsiella cystitis indication 60867007
Otitis media caused by Streptococcus spp. indication 65363002 DOID:10754
Acute maxillary sinusitis indication 68272006 DOID:2050
Haemophilus influenzae pneumonia indication 70036007
Acute bacterial sinusitis indication 75498004
Bacterial conjunctivitis indication 128350005 DOID:9700
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Acute Moraxella catarrhalis bronchitis indication 195722003
Acute bacterial bronchitis indication 233598009
Pneumococcal pneumonia indication 233607000
Chlamydial pneumonia indication 233609002
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Streptococcus pyogenes infection indication 302809008
Bacterial urinary infection indication 312124009
Infection due to Staphylococcus aureus indication 406602003
Anthrax indication 409498004 DOID:7427
Acute exacerbation of chronic bronchitis indication 425748003
Otitis media caused by Moraxella (Branhamella) catarrhalis indication 703469002
Otitis media caused by Enterobacter spp. indication 703469002
Otitis media caused by Serratia spp. indication 703469002
Otitis media caused by Acinetobacter spp. indication 703469002
Otitis media caused by Staphylococcus spp. indication 703469002
Otitis media caused by Klebsiella pneumoniae indication 703469002
Otitis media caused by Streptococcus pneumoniae indication 721742004
Otitis externa caused by Acinetobacter spp. indication 280221000009107
Otitis externa caused by Streptococcus pneumoniae indication 280221000009107
Otitis externa caused by Staphylococcus spp. indication 280221000009107
Otitis externa caused by Serratia spp. indication 280221000009107
Otitis externa caused by Pseudomonas aeruginosa indication 280221000009107
Otitis externa caused by Streptococcus spp. indication 280221000009107
Otitis externa caused by Moraxella (Branhamella) catarrhalis indication 280221000009107
Otitis externa caused by Klebsiella pneumoniae indication 280221000009107
Otitis externa caused by Haemophilus influenzae indication 280221000009107
Otitis externa caused by Enterobacter spp. indication 280221000009107
Chronic Staphylococcus epidermidis Prostatitis indication
Complicated Skin and Skin Structure Proteus Infection indication
Nosocomial Pneumonia due to Methicillin-Sensitive Staphylococcus Aureus indication
Haemophilus Influenzae Bronchitis indication
Chronic Enterococcus faecalis Prostatitis indication
Nosocomial Pneumonia due to Streptococcus Pneumoniae indication
Haemophilus Parainfluenzae Bronchitis indication
Synergy for Nosocomial Pneumonia due to Pseudomonas Aeruginosa indication
Haemophilus Parainfluenzae Pneumonia indication
Complicated Skin and Skin Structure Streptococcus Pyogenes Infection indication
Nosocomial Pneumonia due to Klebsiella Pneumoniae indication
Bacterial Corneal Ulcer Infection indication
Chronic Escherichia coli Prostatitis indication
Complicated Skin and Skin Structure Staphylococcus Aureus Infection indication
Complicated Urinary Tract Infections indication
Enterococcus Urinary Tract Infection indication
Complicated Skin and Skin Structure Enterococcus Faecalis Infection indication
Legionella Pneumophila Pneumonia indication
Gram-Negative Aerobic Bacillary Pneumonia indication
Nosocomial Pneumonia due to Haemophilus Influenzae indication
Nosocomial Pneumonia due to Serratia Marcescens indication
E. Coli Pyelonephritis indication
Streptococcus Pneumoniae Bronchitis indication
Nosocomial Pneumonia due to Escherichia Coli indication
Complicated Skin and Skin Structure Infection indication
Staphylococcus Saprophyticus Urinary Tract Infection indication
Staphylococcus Aureus Bronchitis indication
Moraxella Catarrhalis Pneumonia indication
Pseudomonas Aeruginosa Urinary Tract Infection indication
Traveler's diarrhea off-label use 11840006
Acute tuberculosis off-label use 25629007
Pulmonary tuberculosis off-label use 154283005 DOID:2957
Diabetic Foot Infection off-label use
Hallucinations contraindication 7011001
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Torsades de pointes contraindication 31722008
Transplantation of heart contraindication 32413006
Tendinitis contraindication 34840004 DOID:971
Hypokalemia contraindication 43339004
Bradycardia contraindication 48867003
Transplant of kidney contraindication 70536003
Diabetes mellitus contraindication 73211009 DOID:9351
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Transplant of lung contraindication 88039007
Myasthenia gravis contraindication 91637004 DOID:437
Prolonged QT interval contraindication 111975006
Pancytopenia contraindication 127034005 DOID:12450
Impaired renal function disorder contraindication 197663003
Disease of liver contraindication 235856003 DOID:409
Drug-induced hepatitis contraindication 235876009
Rhabdomyolysis contraindication 240131006
Anemia contraindication 271737000 DOID:2355
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Peripheral nerve disease contraindication 302226006
Pseudomembranous enterocolitis contraindication 397683000
Myocardial ischemia contraindication 414795007 DOID:3393
Traumatic rupture of tendon contraindication 415749005
Congenital long QT syndrome contraindication 442917000
Severe Cerebral Arteriosclerosis contraindication
Tremors contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.12 acidic
pKa2 8.29 Basic
pKa3 1.12 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 3.04 WOMBAT-PK
Multidrug and toxin extrusion protein 1 Transporter IC50 4.75 CHEMBL
CAAX prenyl protease 2 Enzyme AC50 4.39 CHEMBL
DNA topoisomerase 4 Enzyme INHIBITOR CHEMBL CHEMBL
DNA gyrase Enzyme INHIBITOR CHEMBL CHEMBL
DNA gyrase subunit A Enzyme IC50 4.28 CHEMBL

External reference:

IDSource
D00588 KEGG_DRUG
138199-71-0 SECONDARY_CAS_RN
4021005 VANDF
CHEBI:63598 CHEBI
LFX PDB_CHEM_ID
CHEMBL5315124 ChEMBL_ID
CHEMBL33 ChEMBL_ID
10911 IUPHAR_LIGAND_ID
DB01137 DRUGBANK_ID
6GNT3Y5LMF UNII
1546009 RXNORM
182289 MMSL
37941 MMSL
4972 MMSL
6466 MMSL
d04109 MMSL
006299 NDDF
387552007 SNOMEDCT_US
785695006 SNOMEDCT_US
96087006 SNOMEDCT_US
C0282386 UMLSCUI
D064704 MESH_DESCRIPTOR_UI
6708 INN_ID
149096 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9315 INJECTION, SOLUTION 250 mg INTRAVENOUS ANDA 28 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9316 INJECTION, SOLUTION 500 mg INTRAVENOUS ANDA 28 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9317 INJECTION, SOLUTION 750 mg INTRAVENOUS ANDA 28 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9720 INJECTION, SOLUTION 750 mg INTRAVENOUS ANDA 28 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9721 INJECTION, SOLUTION 500 mg INTRAVENOUS ANDA 28 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0143-9722 INJECTION, SOLUTION 250 mg INTRAVENOUS ANDA 28 sections
LEVOFLOXACIN HUMAN PRESCRIPTION DRUG LABEL 1 0409-0528 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 34 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0409-2220 INJECTION, SOLUTION 250 mg INTRAVENOUS ANDA 31 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0409-3330 INJECTION, SOLUTION 500 mg INTRAVENOUS ANDA 31 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0409-4444 INJECTION, SOLUTION 750 mg INTRAVENOUS ANDA 31 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0527-1948 SOLUTION 25 mg ORAL ANDA 29 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0527-1948 SOLUTION 25 mg ORAL ANDA 29 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6351 TABLET, FILM COATED 250 mg ORAL ANDA 26 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6352 TABLET, FILM COATED 500 mg ORAL ANDA 26 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6353 TABLET, FILM COATED 750 mg ORAL ANDA 26 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-143 TABLET, FILM COATED 500 mg ORAL ANDA 28 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-245 TABLET, FILM COATED 750 mg ORAL ANDA 30 sections
levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-451 TABLET, FILM COATED 500 mg ORAL ANDA 28 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-558 TABLET, FILM COATED 500 mg ORAL ANDA 30 sections
Levofloxacin Human Prescription Drug Label 1 10544-624 TABLET, FILM COATED 500 mg ORAL ANDA 30 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 10544-906 TABLET, FILM COATED 750 mg ORAL ANDA 28 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 12634-674 TABLET, FILM COATED 750 mg ORAL ANDA 28 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 12634-675 TABLET, FILM COATED 500 mg ORAL ANDA 28 sections
LEVOFLOXACIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-992 TABLET, FILM COATED 500 mg ORAL ANDA 30 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 17478-106 SOLUTION 5 mg OPHTHALMIC ANDA 24 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 17478-107 INJECTION 25 mg INTRAVENOUS ANDA 28 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 17856-0286 SOLUTION 25 mg ORAL ANDA 27 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 21695-024 TABLET, FILM COATED 250 mg ORAL ANDA 30 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 21695-027 TABLET, FILM COATED 500 mg ORAL ANDA 30 sections
Levofloxacin HUMAN PRESCRIPTION DRUG LABEL 1 21695-041 TABLET, FILM COATED 750 mg ORAL ANDA 30 sections