ilaprazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
antiulcer, benzimidazole derivatives	3961	172152-36-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

IY-81149
IY81149
IY 81149
ilaprazole
noltec

Molecular weight: 366.44
Formula: C19H18N4O2S
CLOGP: 3.13
LIPINSKI: 0
HAC: 6
HDO: 1
TPSA: 72.80
ALOGS: -3.59
ROTB: 5

Drug dosage:

None

ADMET properties:

Property	Value	Reference
Vd (Volume of distribution)	0.19 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.73 mL/min/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	3.59 hours	Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IGF1R,ITK,JAK2,JAK3,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MELK,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70	59
kinase-selectivity-class	AXL	1
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
Oct. 28, 2008	Korean Food and Drug Administration (KFDA)

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Occupational dermatitis	81.73	70.04	9	147	97	42621082

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Occupational dermatitis	81.32	59.21	9	263	154	110588873
Occupational exposure to air contaminants	70.90	59.21	8	264	164	110588863

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A02BC11	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Proton pump inhibitors
CHEBI has role	CHEBI:49201	anti-ulcer drug

Related Drugs by ATC class:

A02BC Proton pump inhibitors 8 drugs

dexlansoprazole dexrabeprazole esomeprazole lansoprazole omeprazole pantoprazole rabeprazole vonoprazan

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Peptic ulcer	indication	13200003	DOID:750
Gastroesophageal reflux disease	indication	235595009	DOID:8534

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.28	acidic
pKa2	4.05	Basic
pKa3	3.35	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Potassium-transporting ATPase	Transporter	P20648 P51164	ATP4A_HUMAN ATP4B_HUMAN	INHIBITOR				SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
C1881129	UMLSCUI
CHEBI:135544	CHEBI
CHEMBL2106370	ChEMBL_ID
DB11964	DRUGBANK_ID
C119615	MESH_SUPPLEMENTAL_RECORD_UI
214351	PUBCHEM_CID
10512	IUPHAR_LIGAND_ID
8158	INN_ID
776Q6XX45J	UNII
776Q6XX45J	INXIGHT DRUGS

Pharmaceutical products:

None