ilaprazole Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiulcer, benzimidazole derivatives 3961 172152-36-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • IY-81149
  • IY81149
  • IY 81149
  • ilaprazole
  • noltec
  • Molecular weight: 366.44
  • Formula: C19H18N4O2S
  • CLOGP: 3.13
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 72.80
  • ALOGS: -3.59
  • ROTB: 5

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.19 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.73 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.59 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 28, 2008 Korean Food and Drug Administration (KFDA)

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Gastroesophageal reflux disease indication 235595009 DOID:8534

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.28 acidic
pKa2 4.05 Basic
pKa3 3.35 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium-transporting ATPase Transporter INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
C1881129 UMLSCUI
CHEBI:135544 CHEBI
CHEMBL2106370 ChEMBL_ID
DB11964 DRUGBANK_ID
C119615 MESH_SUPPLEMENTAL_RECORD_UI
10512 IUPHAR_LIGAND_ID
8158 INN_ID
776Q6XX45J UNII
214351 PUBCHEM_CID

Pharmaceutical products:

None