lansoprazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antiulcer, benzimidazole derivatives 1547 103577-45-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prevacid
  • lansoprazole
  • A-65006
  • AG 1749
  • AG-1749
A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.
  • Molecular weight: 369.36
  • Formula: C16H14F3N3O2S
  • CLOGP: 2.79
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 67.87
  • ALOGS: -3.17
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.35 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 81 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.28 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP3K1,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PDK1,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ZAP70 50
kinase-selectivity-class AXL 1
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 4.436 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 1
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 Moderate 0.73
rat-kpuu-brain Rat brain Kpuu 0.216 % High 1

Approvals:

DateAgencyCompanyOrphan
May 10, 1995 FDA TAKEDA PHARMS USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 984.84 9.12 2171 319948 1382127 88924201
Chronic kidney disease 750.40 9.12 909 321210 49282 90257046
Colitis microscopic 541.29 9.12 390 321729 10769 90295559
Renal injury 362.91 9.12 297 321822 9946 90296382
Hyponatraemia 335.12 9.12 1141 320978 132397 90173931
Completed suicide 333.38 9.12 57 322062 145001 90161327
Product dose omission issue 309.59 9.12 348 321771 291339 90014989
Off label use 263.23 9.12 2579 319540 1099673 89206655
Death 246.09 9.12 817 321302 455734 89850594
End stage renal disease 239.57 9.12 217 321902 8354 90297974
Acute kidney injury 239.22 9.12 1951 320168 318436 89987892
Therapeutic product effect incomplete 235.97 9.12 205 321914 193691 90112637
Swollen tongue 208.52 9.12 487 321632 45469 90260859
Fatigue 207.08 9.12 2876 319243 1151147 89155181
Pain 201.52 9.12 2421 319698 993920 89312408
Chest pain 194.34 9.12 1861 320258 317784 89988544
Toxicity to various agents 189.54 9.12 468 321651 287378 90018950
Hypomagnesaemia 185.98 9.12 399 321720 35189 90271139
Angioedema 183.01 9.12 577 321542 64299 90242029
Injection site pain 180.10 9.12 211 321908 173488 90132840
Subacute cutaneous lupus erythematosus 173.28 9.12 125 321994 3457 90302871
Lip swelling 164.19 9.12 399 321720 38211 90268117
Lower respiratory tract infection 159.59 9.12 1474 320645 249185 90057143
Contraindicated product administered 153.69 9.12 601 321518 319538 89986790
Liver disorder 145.14 9.12 830 321289 120439 90185889
Deep vein thrombosis postoperative 133.36 9.12 552 321567 70257 90236071
Interstitial lung disease 127.31 9.12 574 321545 75831 90230497
Abdominal pain upper 126.20 9.12 1768 320351 330906 89975422
Lower limb fracture 125.08 9.12 616 321503 84397 90221931
Exposure during pregnancy 122.58 9.12 435 321684 237975 90068353
Injection site reaction 121.18 9.12 90 322029 91990 90214338
Neutropenic sepsis 117.08 9.12 222 321897 17908 90288420
Cardiospasm 113.92 9.12 96 322023 3350 90302978
Autoimmune disorder 113.56 9.12 557 321562 76187 90230141
Hypertensive nephropathy 113.22 9.12 53 322066 625 90305703
Palmoplantar keratoderma 112.45 9.12 96 322023 3411 90302917
Swelling face 112.32 9.12 579 321540 80773 90225555
Device expulsion 111.31 9.12 9 322110 40877 90265451
Renal failure 109.87 9.12 820 321299 130187 90176141
Subarachnoid haemorrhage 108.00 9.12 213 321906 17691 90288637
Electric shock 106.71 9.12 70 322049 1652 90304676
Lip dry 103.63 9.12 664 321455 100291 90206037
Pruritus genital 101.89 9.12 102 322017 4456 90301872
Drug intolerance 101.75 9.12 1058 321061 446533 89859795
X-ray abnormal 100.86 9.12 373 321746 45051 90261277
Sleep terror 98.14 9.12 99 322020 4365 90301963
Adjustment disorder with depressed mood 97.27 9.12 430 321689 56323 90250005
Urticaria 96.19 9.12 1604 320515 311130 89995198
Cerebral infarction 95.62 9.12 258 321861 26338 90279990
Inappropriate schedule of product administration 94.57 9.12 249 321870 149684 90156644
Accidental exposure to product 94.37 9.12 18 322101 42348 90263980
Amnesia 92.59 9.12 682 321437 107823 90198505
Confusional state 91.11 9.12 1901 320218 384304 89922024
Atrial tachycardia 90.31 9.12 109 322010 5881 90300447
Tubulointerstitial nephritis 89.26 9.12 244 321875 25099 90281229
Treatment failure 87.63 9.12 676 321443 303252 90003076
Therapeutic product effect decreased 87.42 9.12 602 321517 276969 90029359
Agranulocytosis 85.03 9.12 296 321823 34706 90271622
Macular degeneration 82.76 9.12 17 322102 37953 90268375
Melaena 82.57 9.12 292 321827 34505 90271823
Peripheral venous disease 79.48 9.12 541 321578 83380 90222948
Hepatic function abnormal 78.79 9.12 350 321769 45938 90260390
Tension headache 78.22 9.12 114 322005 7395 90298933
Drug abuse 78.07 9.12 107 322012 82240 90224088
Immunisation 78.04 9.12 64 322055 2149 90304179
Product use issue 77.75 9.12 773 321346 329146 89977182
Oedema 76.88 9.12 1067 321052 199228 90107100
Carotid artery occlusion 76.05 9.12 103 322016 6239 90300089
Liver injury 75.65 9.12 933 321186 169634 90136694
Injection site erythema 74.74 9.12 148 321971 98354 90207974
Suicide attempt 74.51 9.12 95 322024 75304 90231024
Blood pressure increased 73.93 9.12 405 321714 196812 90109516
Lupus vulgaris 73.17 9.12 336 321783 44723 90261605
Wheezing 72.75 9.12 1220 320899 236860 90069468
Therapy interrupted 72.61 9.12 44 322075 50064 90256264
Abdominal pain 72.36 9.12 1880 320239 393841 89912487
Blood lactic acid decreased 72.11 9.12 34 322085 408 90305920
Injection site swelling 71.86 9.12 64 322055 59775 90246553
Lung disorder 71.79 9.12 832 321287 149051 90157277
Injection site pruritus 71.63 9.12 52 322067 53782 90252546
Influenza 71.61 9.12 254 321865 139010 90167318
Delirium 70.56 9.12 622 321497 103737 90202591
Myelosuppression 69.71 9.12 53 322066 53538 90252790
Road traffic accident 68.95 9.12 634 321485 106992 90199336
Haematemesis 68.34 9.12 269 321850 33457 90272871
Loss of personal independence in daily activities 68.15 9.12 251 321868 135854 90170474
Dry mouth 67.22 9.12 972 321147 183087 90123241
Cholecystitis chronic 66.79 9.12 123 321996 9703 90296625
Foetal exposure during pregnancy 66.20 9.12 35 322084 42940 90263388
Rectal haemorrhage 66.03 9.12 512 321607 82232 90224096
Pulmonary fibrosis 65.73 9.12 627 321492 106876 90199452
Maternal exposure during pregnancy 65.30 9.12 894 321225 359169 89947159
COVID-19 64.79 9.12 344 321775 168499 90137829
Porphyria acute 63.24 9.12 173 321946 17802 90288526
Cardiac output increased 62.96 9.12 33 322086 504 90305824
Vitamin B1 decreased 62.91 9.12 33 322086 505 90305823
Onychomycosis 62.84 9.12 27 322092 37349 90268979
Swollen joint count increased 61.87 9.12 636 321483 110570 90195758
Hallucination 61.73 9.12 424 321695 65535 90240793
Diabetic nephropathy 60.84 9.12 50 322069 1684 90304644
Type 2 diabetes mellitus 60.44 9.12 1037 321082 202207 90104121
Musculoskeletal pain 60.42 9.12 899 321220 170352 90135976
Intervertebral discitis 59.74 9.12 77 322042 4443 90301885
Joint range of motion decreased 59.72 9.12 741 321378 134902 90171426
Asthma 59.67 9.12 1200 320919 240960 90065368
C-reactive protein 58.63 9.12 244 321875 31123 90275205
Nephrogenic anaemia 58.49 9.12 57 322062 2409 90303919
Cholestasis 58.44 9.12 270 321849 36029 90270299
Wrong technique in product usage process 58.30 9.12 103 322016 71468 90234860
Facial pain 57.94 9.12 138 321981 13044 90293284
Dislocation of vertebra 57.35 9.12 368 321751 55600 90250728
Bursitis 57.01 9.12 717 321402 130937 90175391
Hepatotoxicity 56.29 9.12 48 322071 45794 90260534
Reaction to excipient 55.77 9.12 49 322070 1811 90304517
Total lung capacity decreased 55.50 9.12 68 322051 3727 90302601
Subcutaneous drug absorption impaired 55.48 9.12 138 321981 13407 90292921
Labile blood pressure 54.64 9.12 49 322070 1861 90304467
Food allergy 54.31 9.12 12 322107 25466 90280862
Device dislocation 54.13 9.12 22 322097 31460 90274868
Blood cholesterol increased 54.01 9.12 1039 321080 206973 90099355
Muscle twitching 53.95 9.12 199 321920 24003 90282325
Mixed liver injury 53.82 9.12 97 322022 7526 90298802
Rebound acid hypersecretion 53.58 9.12 26 322093 334 90305994
Rhinorrhoea 53.18 9.12 150 321969 88166 90218162
Drug resistance 52.80 9.12 21 322098 30428 90275900
Foetal death 52.62 9.12 6 322113 20717 90285611
Hypokalaemia 52.54 9.12 704 321415 130412 90175916
Red blood cell sedimentation rate abnormal 52.41 9.12 11 322108 24193 90282135
Nephropathy 52.27 9.12 107 322012 9128 90297200
Overdose 52.15 9.12 337 321782 157372 90148956
Pancreatitis 51.85 9.12 425 321694 69401 90236927
Rash vesicular 50.52 9.12 161 321958 18036 90288292
Decreased appetite 50.11 9.12 1720 320399 374820 89931508
Muscle injury 49.89 9.12 894 321225 175760 90130568
Sopor 49.47 9.12 196 321923 24448 90281880
Anosmia 48.70 9.12 108 322011 9740 90296588
Immunodeficiency 48.68 9.12 49 322070 43185 90263143
Injury 48.62 9.12 978 321141 196371 90109957
C-reactive protein abnormal 48.53 9.12 678 321441 126751 90179577
Bronchopulmonary aspergillosis allergic 47.97 9.12 63 322056 3703 90302625
Post cholecystectomy syndrome 47.85 9.12 33 322086 848 90305480
Glomerular filtration rate increased 47.71 9.12 47 322072 2013 90304315
Hypocalcaemia 47.43 9.12 285 321834 42083 90264245
Therapy cessation 47.24 9.12 36 322083 36325 90270003
Hepatocellular injury 47.06 9.12 216 321903 28742 90277586
Intentional overdose 47.00 9.12 173 321946 93661 90212667
Hypergastrinaemia 46.96 9.12 18 322101 123 90306205
Joint swelling 46.44 9.12 1398 320721 501902 89804426
Wound infection 46.28 9.12 580 321539 105822 90200506
Grip strength 46.24 9.12 100 322019 8865 90297463
Adverse reaction 46.06 9.12 24 322095 29688 90276640
Liver function test abnormal 45.32 9.12 323 321796 50522 90255806
Product dose omission in error 45.06 9.12 9 322110 20494 90285834
Night sweats 45.02 9.12 675 321444 128091 90178237
Brain stem glioma 44.98 9.12 19 322100 172 90306156
Abortion spontaneous 44.74 9.12 77 322042 53979 90252349
Demyelination 44.53 9.12 93 322026 8047 90298281
Illness 43.82 9.12 147 321972 81822 90224506
Infective pulmonary exacerbation of cystic fibrosis 43.45 9.12 106 322013 10173 90296155
Obesity 43.31 9.12 569 321550 104938 90201390
Oedema peripheral 43.28 9.12 1212 320907 256703 90049625
Coeliac disease 43.26 9.12 57 322062 44553 90261775
Disease progression 42.94 9.12 353 321766 156262 90150066
Aspiration 42.80 9.12 138 321981 15555 90290773
Respiratory tract congestion 42.70 9.12 22 322097 27388 90278940
Transient ischaemic attack 41.86 9.12 280 321839 42896 90263432
Back injury 41.80 9.12 63 322056 46559 90259769
Breast cancer stage II 41.04 9.12 240 321879 35094 90271234
Lung opacity 40.99 9.12 76 322043 6026 90300302
Renal impairment 40.17 9.12 561 321558 104860 90201468
Facet joint syndrome 40.12 9.12 530 321589 97859 90208469
Myositis 39.97 9.12 181 321938 23947 90282381
Eye injury 39.71 9.12 107 322012 10913 90295415
Post-traumatic stress disorder 39.70 9.12 80 322039 6748 90299580
Injection site bruising 39.32 9.12 79 322040 52228 90254100
Neoplasm progression 39.03 9.12 61 322058 44425 90261903
Stress 38.86 9.12 153 321966 81242 90225086
Biliary dyskinesia 38.70 9.12 47 322072 2552 90303776
Therapy partial responder 38.56 9.12 15 322104 22028 90284300
Arthralgia 38.37 9.12 2321 319798 776201 89530127
No adverse event 38.37 9.12 119 322000 67863 90238465
Skin haemorrhage 38.32 9.12 14 322105 21366 90284962
General symptom 38.22 9.12 127 321992 14541 90291787
Hospitalisation 37.78 9.12 283 321836 127817 90178511
Upper respiratory tract inflammation 37.66 9.12 47 322072 2625 90303703
Multiple sclerosis relapse 37.63 9.12 81 322038 52224 90254104
Sciatica 37.63 9.12 537 321582 100845 90205483
Inappropriate antidiuretic hormone secretion 37.45 9.12 153 321966 19352 90286976
Proctitis 37.32 9.12 5 322114 15254 90291074
Pleuritic pain 37.12 9.12 101 322018 10360 90295968
Pustular psoriasis 36.78 9.12 147 321972 18409 90287919
White blood cell count increased 36.65 9.12 383 321736 66858 90239470
Reflux gastritis 36.23 9.12 34 322085 1370 90304958
Lethargy 36.01 9.12 363 321756 62776 90243552
Pemphigoid 35.96 9.12 91 322028 8935 90297393
Product storage error 35.03 9.12 14 322105 20227 90286101
Hyperlactacidaemia 34.95 9.12 57 322062 4079 90302249
Cholecystitis acute 34.58 9.12 92 322027 9312 90297016
Onychomadesis 34.13 9.12 70 322049 45928 90260400
International normalised ratio increased 34.06 9.12 286 321833 47030 90259298
Alopecia 34.01 9.12 1426 320693 493645 89812683
Coma scale abnormal 34.01 9.12 67 322052 5559 90300769
Device difficult to use 34.00 9.12 10 322109 17515 90288813
Hypophosphataemic osteomalacia 34.00 9.12 17 322102 234 90306094
Hepatorenal syndrome 33.74 9.12 39 322080 2009 90304319
Somatic delusion 33.35 9.12 23 322096 591 90305737
Sinus congestion 33.32 9.12 29 322090 27395 90278933
Crohn's disease 33.32 9.12 61 322058 4790 90301538
Electrocardiogram QT prolonged 33.25 9.12 399 321720 72057 90234271
Faeces discoloured 33.15 9.12 157 321962 21163 90285165
Prescribed overdose 33.06 9.12 509 321610 97116 90209212
Full blood count decreased 33.02 9.12 34 322085 29655 90276673
Blood immunoglobulin A increased 32.98 9.12 31 322088 1252 90305076
Chronic sinusitis 32.97 9.12 22 322097 23780 90282548
Vitamin B1 increased 32.96 9.12 15 322104 165 90306163
Hepatic cytolysis 32.73 9.12 205 321914 30711 90275617
Drug reaction with eosinophilia and systemic symptoms 32.69 9.12 262 321857 42496 90263832
Hepatic ischaemia 32.61 9.12 25 322094 760 90305568
Hyperparathyroidism secondary 32.58 9.12 36 322083 1765 90304563
Urine magnesium decreased 32.50 9.12 7 322112 0 90306328
Muscle spasticity 32.38 9.12 47 322072 35275 90271053
Jaundice 32.20 9.12 212 321907 32305 90274023
Nephrocalcinosis 32.11 9.12 30 322089 1202 90305126
Toxic skin eruption 32.10 9.12 126 321993 15648 90290680
Irritable bowel syndrome 32.09 9.12 965 321154 206483 90099845
Hyperglycaemia 32.00 9.12 299 321820 50671 90255657
Psoriasis 31.98 9.12 353 321766 147401 90158927
Granulocyte count increased 31.87 9.12 33 322086 1501 90304827
Skin candida 31.84 9.12 35 322084 1706 90304622
Product label confusion 31.82 9.12 21 322098 22829 90283499
Purpura 31.68 9.12 120 321999 14658 90291670
Fall 31.60 9.12 1395 320724 480415 89825913
Circulatory collapse 31.46 9.12 173 321946 24731 90281597
Medication error 31.26 9.12 448 321671 84204 90222124
Procedural pain 30.96 9.12 44 322075 33316 90273012
Vasculitis 30.95 9.12 161 321958 22532 90283796
Blood alkaline phosphatase increased 30.67 9.12 283 321836 47796 90258532
Therapeutic response shortened 30.56 9.12 22 322097 22857 90283471
Nasal congestion 30.31 9.12 173 321946 83241 90223087
Erythema multiforme 30.12 9.12 104 322015 12142 90294186
Disease recurrence 29.93 9.12 55 322064 37598 90268730
Finger deformity 29.93 9.12 44 322075 32853 90273475
Bone pain 29.92 9.12 116 322003 61867 90244461
Limb discomfort 29.90 9.12 56 322063 38004 90268324
Haemoptysis 29.89 9.12 212 321907 33108 90273220
Cystitis 29.62 9.12 129 321990 66589 90239739
Sinus disorder 29.50 9.12 48 322071 34399 90271929
Hyperkalaemia 29.49 9.12 357 321762 64607 90241721
Gastritis 29.33 9.12 251 321868 41502 90264826
Pain in extremity 28.81 9.12 1308 320811 449221 89857107
Premature delivery 28.75 9.12 59 322060 38703 90267625
Radiculopathy 28.60 9.12 15 322104 18490 90287838
Panniculitis 28.51 9.12 8 322111 14450 90291878
Basilar artery occlusion 28.44 9.12 14 322105 186 90306142
Pain of skin 28.43 9.12 123 321996 15959 90290369
Female genital tract fistula 28.34 9.12 14 322105 17854 90288474
Personality disorder 28.33 9.12 5 322114 12439 90293889
Swollen joint count 28.20 9.12 81 322038 8572 90297756
Intentional dose omission 28.11 9.12 14 322105 17769 90288559
Fibromyalgia 28.10 9.12 945 321174 205324 90101004
Nasal polyps 28.00 9.12 3 322116 10877 90295451
Progressive multifocal leukoencephalopathy 27.88 9.12 120 321999 15535 90290793
Urine phosphorus decreased 27.86 9.12 6 322113 0 90306328
Gait inability 27.64 9.12 699 321420 145757 90160571
Poisoning deliberate 27.57 9.12 12 322107 16474 90289854
Ulcer haemorrhage 27.54 9.12 174 321945 26147 90280181
Rheumatoid nodule 27.45 9.12 19 322100 20147 90286181
Exposure via skin contact 27.43 9.12 3 322116 10702 90295626
Injection site warmth 27.37 9.12 14 322105 17501 90288827
Back disorder 27.16 9.12 170 321949 25461 90280867
Hyperchlorhydria 27.13 9.12 34 322085 1907 90304421
Oesophagitis 26.81 9.12 127 321992 17122 90289206
Urine potassium decreased 26.75 9.12 7 322112 9 90306319
Sedation 26.70 9.12 85 322034 48086 90258242
Diarrhoea 26.61 9.12 3766 318353 935424 89370904
Complication of device insertion 26.55 9.12 3 322116 10433 90295895
Haematotoxicity 26.53 9.12 6 322113 12529 90293799
Surgery 26.46 9.12 77 322042 44810 90261518
Incorrect dose administered 26.42 9.12 168 321951 78762 90227566
Device issue 26.39 9.12 40 322079 29497 90276831
Sleep disorder due to general medical condition, insomnia type 26.32 9.12 621 321498 128073 90178255
Disseminated intravascular coagulation 26.13 9.12 148 321971 21390 90284938
Injection site mass 26.07 9.12 24 322095 22066 90284262
Coordination abnormal 26.07 9.12 147 321972 21209 90285119
Achlorhydria 25.93 9.12 7 322112 11 90306317
Eye irritation 25.81 9.12 51 322068 33927 90272401
Walking aid user 25.76 9.12 215 321904 35291 90271037
Rheumatoid factor increased 25.69 9.12 37 322082 2374 90303954
Hip fracture 25.69 9.12 49 322070 33028 90273300
Coronary artery disease 25.69 9.12 206 321913 33417 90272911
Breast cancer stage III 25.49 9.12 432 321687 84015 90222313
Deformity 25.41 9.12 6 322113 12164 90294164
Pneumonia 25.25 9.12 1939 320180 636120 89670208
Aspartate aminotransferase 25.13 9.12 21 322098 724 90305604
Gastric polyps 25.12 9.12 53 322066 4619 90301709
Rheumatoid factor positive 25.08 9.12 793 321326 170857 90135471
Hypophosphataemia 25.03 9.12 112 322007 14742 90291586
Ventricular tachycardia 25.02 9.12 162 321957 24546 90281782
Intentional self-injury 25.00 9.12 41 322078 29293 90277035
Oesophageal achalasia 25.00 9.12 20 322099 648 90305680
Post viral fatigue syndrome 24.83 9.12 14 322105 249 90306079
Folliculitis 24.81 9.12 924 321195 203429 90102899
Seasonal allergy 24.80 9.12 27 322092 22956 90283372
Basal cell carcinoma 24.61 9.12 51 322068 33338 90272990
Device malfunction 24.51 9.12 23 322096 20954 90285374
Vomiting 24.42 9.12 3178 318941 785115 89521213
Temperature intolerance 24.41 9.12 96 322023 11934 90294394
Blood albumin abnormal 24.38 9.12 25 322094 1124 90305204
Skin necrosis 24.37 9.12 15 322104 16926 90289402
Herpes zoster 24.29 9.12 217 321902 94427 90211901
Tinnitus 24.19 9.12 247 321872 42855 90263473
Respiratory tract infection 23.99 9.12 118 322001 58960 90247368
Vitamin B12 increased 23.97 9.12 31 322088 1795 90304533
Duodenal ulcer perforation 23.91 9.12 988 321131 220300 90086028
Rheumatic fever 23.86 9.12 713 321406 152408 90153920
Human T-cell lymphotropic virus infection 23.72 9.12 6 322113 6 90306322
Blood parathyroid hormone decreased 23.65 9.12 7 322112 12209 90294119
Condition aggravated 23.37 9.12 1811 320308 593734 89712594
Sensory loss 23.35 9.12 18 322101 18057 90288271
Injection site rash 23.32 9.12 31 322088 24142 90282186
Marasmus 23.32 9.12 21 322098 802 90305526
Hyponatraemic syndrome 23.23 9.12 18 322101 556 90305772
Unevaluable event 23.17 9.12 108 322011 54740 90251588
Pituitary tumour benign 23.13 9.12 33 322086 2099 90304229
Musculoskeletal disorder 23.02 9.12 26 322093 21743 90284585
Infusion related reaction 22.74 9.12 1230 320889 415550 89890778
Nail ridging 22.72 9.12 17 322102 498 90305830
Photodermatosis 22.66 9.12 18 322101 577 90305751
Product use in unapproved indication 22.54 9.12 971 321148 335265 89971063
Renal tubular acidosis 22.47 9.12 34 322085 2281 90304047
Eosinophilia 22.45 9.12 176 321943 28357 90277971
Arthropathy 22.25 9.12 1069 321050 365173 89941155
Cough 22.21 9.12 1078 321041 367884 89938444
Erythema dyschromicum perstans 22.16 9.12 9 322110 73 90306255
Skin exfoliation 21.99 9.12 146 321973 67767 90238561
Blood lactic acid 21.97 9.12 10 322109 110 90306218
Bronchitis 21.85 9.12 397 321722 152530 90153798
Neuropathy, ataxia, retinitis pigmentosa syndrome 21.75 9.12 8 322111 48 90306280
Product preparation error 21.54 9.12 5 322114 10256 90296072
Acne 21.47 9.12 43 322076 28464 90277864
Carbuncle 21.44 9.12 26 322093 1410 90304918
Metastases to bone 21.41 9.12 36 322083 25469 90280859
Muscle relaxant therapy 21.34 9.12 11 322108 162 90306166
Haemorrhage subcutaneous 21.21 9.12 41 322078 3355 90302973
Hypoglycaemic coma 21.05 9.12 38 322081 2952 90303376
Hypoglobulinaemia 20.99 9.12 11 322108 168 90306160
Anaphylactic reaction 20.96 9.12 432 321687 87092 90219236
Enthesopathy 20.93 9.12 4 322115 9400 90296928
Blood alkaline phosphatase abnormal 20.80 9.12 25 322094 1343 90304985
Musculoskeletal toxicity 20.78 9.12 17 322102 569 90305759
Joint injury 20.77 9.12 54 322065 32610 90273718
Maternal exposure timing unspecified 20.72 9.12 144 321975 22339 90283989
Blood pressure systolic increased 20.66 9.12 122 321997 58223 90248105
Rectal ulcer 20.56 9.12 26 322093 1472 90304856
Wrong patient received product 20.53 9.12 41 322078 3436 90302892
Weight increased 20.52 9.12 1246 320873 416681 89889647
Oesophageal mucosal tear 20.40 9.12 6 322113 15 90306313
Renal tubular disorder 20.37 9.12 39 322080 3168 90303160
Chills 20.34 9.12 338 321781 131643 90174685
Fear of injection 20.33 9.12 3 322116 8512 90297816
Secretion discharge 20.32 9.12 16 322103 15880 90290448
Altered state of consciousness 20.31 9.12 186 321933 31346 90274982
Osteoarthritis 20.26 9.12 870 321249 194860 90111468
Dermatitis exfoliative 20.20 9.12 54 322065 5482 90300846
Face oedema 20.12 9.12 147 321972 23171 90283157
Chest wall mass 20.03 9.12 17 322102 599 90305729
Renal cyst 19.87 9.12 95 322024 12855 90293473
Therapy non-responder 19.82 9.12 631 321488 136073 90170255
Dysphagia 19.77 9.12 531 321588 111747 90194581
Endocarditis enterococcal 19.73 9.12 12 322107 247 90306081
Blood uric acid increased 19.45 9.12 66 322053 7638 90298690
Anxiety 19.28 9.12 1313 320806 308459 89997869
Blood pressure abnormal 19.15 9.12 25 322094 19620 90286708
Gastric dysplasia 19.13 9.12 6 322113 20 90306308
Excessive eye blinking 19.12 9.12 24 322095 1348 90304980
Laryngeal pain 19.12 9.12 46 322073 4376 90301952
Pancreatitis acute 18.97 9.12 186 321933 31929 90274399
Malaise 18.95 9.12 2369 319750 583617 89722711
Diplopia 18.81 9.12 170 321949 28544 90277784
Sinusitis 18.81 9.12 1012 321107 342076 89964252
Upper gastrointestinal haemorrhage 18.78 9.12 143 321976 22833 90283495
Carcinoid tumour of the stomach 18.67 9.12 10 322109 160 90306168
Femoral neck fracture 18.65 9.12 79 322040 10154 90296174
Creatinine renal clearance decreased 18.47 9.12 24 322095 18875 90287453
Loose tooth 18.45 9.12 41 322078 3702 90302626
Dysphonia 18.41 9.12 321 321798 62763 90243565
Oropharyngeal pain 18.41 9.12 293 321826 114894 90191434
Arterial intramural haematoma 18.34 9.12 10 322109 166 90306162
Oropharyngeal oedema 18.16 9.12 13 322106 355 90305973
Muscle tension dysphonia 18.15 9.12 12 322107 287 90306041
Hypocalciuria 18.10 9.12 5 322114 9 90306319
Adrenal insufficiency 18.02 9.12 174 321945 29747 90276581
Hypervolaemia 18.02 9.12 58 322061 32699 90273629
Hospice care 18.00 9.12 6 322113 9698 90296630
Carotid artery thrombosis 17.99 9.12 5 322114 9087 90297241
Cardiotoxicity 17.95 9.12 9 322110 11380 90294948
Enterochromaffin cell hyperplasia 17.88 9.12 7 322112 51 90306277
Blood sodium decreased 17.84 9.12 163 321956 27450 90278878
Drug dose omission by device 17.83 9.12 7 322112 10224 90296104
Anticoagulation drug level abnormal 17.80 9.12 9 322110 127 90306201
Deep vein thrombosis 17.79 9.12 439 321680 91181 90215147
Restlessness 17.79 9.12 66 322053 35654 90270674
Trisomy 21 17.75 9.12 14 322105 444 90305884
Rapid eye movement sleep behaviour disorder 17.64 9.12 13 322106 372 90305956
Cerebral haemorrhage 17.58 9.12 194 321925 34328 90272000
Cardiac disorder 17.55 9.12 124 321995 56748 90249580
Scan abnormal 17.55 9.12 16 322103 621 90305707
Injection site urticaria 17.48 9.12 23 322096 17988 90288340
Polyneuropathy 17.47 9.12 26 322093 19315 90287013
Deja vu 17.43 9.12 9 322110 133 90306195
Oral herpes 17.32 9.12 61 322058 33463 90272865
Palpitations 17.26 9.12 621 321498 136107 90170221
Migraine 17.26 9.12 835 321284 189557 90116771
Chromaturia 17.16 9.12 122 321997 19065 90287263
Activated partial thromboplastin time prolonged 17.15 9.12 64 322055 7761 90298567
Anal prolapse 17.12 9.12 8 322111 94 90306234
Sneezing 17.05 9.12 52 322067 29817 90276511
Iron deficiency anaemia 17.01 9.12 143 321976 23519 90282809
Genital ulceration 16.96 9.12 20 322099 1053 90305275
Pathogen resistance 16.94 9.12 4 322115 8111 90298217
Pneumonia bacterial 16.93 9.12 90 322029 12700 90293628
Stillbirth 16.93 9.12 3 322116 7440 90298888
Urine output decreased 16.90 9.12 89 322030 12514 90293814
Dopamine transporter scintigraphy abnormal 16.82 9.12 8 322111 98 90306230
Vaginal discharge 16.78 9.12 27 322092 19437 90286891
Blood calcium increased 16.76 9.12 86 322033 11972 90294356
Product administration interrupted 16.70 9.12 12 322107 12480 90293848
Schizencephaly 16.66 9.12 12 322107 331 90305997
Thrombosis 16.65 9.12 173 321946 73078 90233250
Aplastic anaemia 16.64 9.12 92 322027 13177 90293151
Breast cancer female 16.61 9.12 17 322102 14869 90291459
Impaired quality of life 16.51 9.12 36 322083 23108 90283220
Cerebral haemorrhage foetal 16.51 9.12 12 322107 336 90305992
Cataract 16.50 9.12 170 321949 71922 90234406
Stoma site haemorrhage 16.45 9.12 22 322097 1316 90305012
Renal atrophy 16.34 9.12 26 322093 1822 90304506
Laryngotracheal oedema 16.31 9.12 6 322113 36 90306292
Swelling 16.31 9.12 1275 320844 417783 89888545
Nodule 16.30 9.12 45 322074 26641 90279687
Palatal ulcer 16.27 9.12 10 322109 210 90306118
Flushing 16.26 9.12 219 321900 88272 90218056
Upper respiratory tract infection 16.24 9.12 340 321779 127978 90178350
Endoscopic retrograde cholangiopancreatography 16.23 9.12 10 322109 211 90306117
Oligohydramnios 16.16 9.12 3 322116 7198 90299130
Multiple allergies 16.12 9.12 18 322101 15128 90291200
Blister 16.07 9.12 1082 321037 253916 90052412
Dermatitis bullous 16.06 9.12 76 322043 10240 90296088
Hypersensitivity pneumonitis 15.93 9.12 40 322079 3908 90302420
Eosinophilic pneumonia chronic 15.82 9.12 10 322109 221 90306107
Uveitis 15.75 9.12 20 322099 15883 90290445
Gestational diabetes 15.74 9.12 9 322110 10573 90295755
Psoriatic arthropathy 15.68 9.12 976 321143 227359 90078969
Injection site haemorrhage 15.67 9.12 50 322069 28268 90278060
Non-economic loss 15.65 9.12 5 322114 18 90306310
Leukocytosis 15.60 9.12 57 322062 30933 90275395
Pre-eclampsia 15.59 9.12 10 322109 11038 90295290
Hypoxic-ischaemic encephalopathy 15.51 9.12 44 322075 4624 90301704
Helicobacter infection 15.45 9.12 969 321150 225881 90080447
Heart rate decreased 15.39 9.12 119 322000 53386 90252942
Insurance issue 15.35 9.12 10 322109 10948 90295380
Gallbladder injury 15.34 9.12 21 322098 1285 90305043
Gastrointestinal motility disorder 15.22 9.12 52 322067 6039 90300289
Hypocholesterolaemia 15.20 9.12 54 322065 6395 90299933
Gangrene 15.18 9.12 14 322105 12862 90293466
Asthenia 15.14 9.12 2141 319978 531610 89774718
Contusion 15.13 9.12 1062 321057 250154 90056174
Rash 15.05 9.12 2544 319575 793556 89512772
Dehydration 15.03 9.12 840 321279 193607 90112721
Pressure of speech 14.99 9.12 16 322103 754 90305574
Biliary sepsis 14.96 9.12 18 322101 968 90305360
Monoclonal immunoglobulin present 14.96 9.12 27 322092 2097 90304231
Pemphigus 14.91 9.12 981 321138 325883 89980445
Transplant rejection 14.89 9.12 14 322105 12744 90293584
Narrow anterior chamber angle 14.85 9.12 6 322113 48 90306280
Infusion site streaking 14.74 9.12 14 322105 573 90305755
Enteritis infectious 14.72 9.12 29 322090 2406 90303922
Red cell distribution width increased 14.72 9.12 13 322106 12194 90294134
Haematochezia 14.72 9.12 171 321948 70742 90235586
Maternal exposure before pregnancy 14.70 9.12 11 322108 11202 90295126
Infusion site pain 14.67 9.12 30 322089 19708 90286620
Synovitis 14.65 9.12 992 321127 328760 89977568
Adjustment disorder 14.63 9.12 8 322111 9634 90296694
Joint effusion 14.62 9.12 30 322089 19680 90286648
Sarcoidosis 14.60 9.12 10 322109 10663 90295665
Drug hypersensitivity 14.58 9.12 1434 320685 462175 89844153
Vascular skin disorder 14.55 9.12 4 322115 7 90306321
Central nervous system lesion 14.54 9.12 12 322107 11634 90294694
Tachypnoea 14.51 9.12 34 322085 21275 90285053
Metastases to liver 14.49 9.12 53 322066 28754 90277574
Blood iron decreased 14.48 9.12 26 322093 17933 90288395
Single functional kidney 14.47 9.12 11 322108 330 90305998
Multiple fractures 14.42 9.12 8 322111 9554 90296774
Hypophagia 14.40 9.12 193 321926 35744 90270584
Dactylitis 14.35 9.12 38 322081 3835 90302493
Mitral valve replacement 14.32 9.12 13 322106 502 90305826
Neutrophil count decreased 14.26 9.12 344 321775 71188 90235140
Device use error 14.23 9.12 4 322115 7217 90299111
Paramnesia 14.21 9.12 4 322115 8 90306320
Poisoning 14.19 9.12 20 322099 15197 90291131
Blood urea increased 14.18 9.12 168 321951 30245 90276083
Hypoacusis 14.17 9.12 51 322068 27799 90278529
Hyperprolactinaemia 14.12 9.12 47 322072 5386 90300942
Hiatus hernia 14.07 9.12 145 321974 25216 90281112
Drug use disorder 14.07 9.12 6 322113 8337 90297991
Acute respiratory failure 14.03 9.12 92 322027 42826 90263502
Caesarean section 14.01 9.12 28 322091 18549 90287779
Skin wrinkling 13.97 9.12 21 322098 1401 90304927
Joint noise 13.96 9.12 46 322073 5244 90301084
Respiratory syncytial virus test positive 13.95 9.12 18 322101 1040 90305288
Urine output 13.93 9.12 3 322116 0 90306328
Neurologic neglect syndrome 13.93 9.12 7 322112 8840 90297488
Oesophageal carcinoma recurrent 13.88 9.12 5 322114 28 90306300
Gallbladder disorder 13.88 9.12 119 322000 19684 90286644
Hypothalamo-pituitary disorder 13.83 9.12 27 322092 2225 90304103
Human herpesvirus 6 infection reactivation 13.83 9.12 14 322105 620 90305708
Neck pain 13.83 9.12 304 321815 113659 90192669
Hepatic enzyme increased 13.81 9.12 1099 321020 359637 89946691
CSF test abnormal 13.79 9.12 13 322106 527 90305801
Oral mucosal discolouration 13.79 9.12 11 322108 355 90305973
Bradycardia 13.76 9.12 393 321726 83454 90222874
Abdominal discomfort 13.71 9.12 1486 320633 475842 89830486
Retinitis 13.59 9.12 202 321917 38256 90268072
Spleen congestion 13.59 9.12 7 322112 103 90306225
Skin irritation 13.58 9.12 17 322102 13586 90292742
Labyrinthitis 13.57 9.12 30 322089 2699 90303629
Skin fissures 13.54 9.12 34 322085 20775 90285553
Throat clearing 13.51 9.12 37 322082 3810 90302518
Upper limb fracture 13.47 9.12 36 322083 21542 90284786
Nightmare 13.41 9.12 127 321992 21598 90284730
Gastric ulcer 13.41 9.12 153 321966 27295 90279033
Lactic acidosis 13.40 9.12 253 321866 50210 90256118
Lupus-like syndrome 13.35 9.12 246 321873 48600 90257728
Cholecystitis 13.34 9.12 105 322014 16935 90289393
SARS-CoV-2 test positive 13.24 9.12 12 322107 11116 90295212
Breast cancer stage I 13.19 9.12 9 322110 9615 90296713
Concussion 13.15 9.12 12 322107 11079 90295249
Pneumococcal infection 13.11 9.12 19 322100 1226 90305102
Palmar erythema 13.09 9.12 24 322095 1887 90304441
Metastases to lung 13.03 9.12 23 322096 15968 90290360
Dizziness 12.97 9.12 2331 319788 586953 89719375
Bile duct stone 12.95 9.12 38 322081 4069 90302259
Renal haemangioma 12.94 9.12 5 322114 35 90306293
Foot operation 12.91 9.12 8 322111 8993 90297335
Drug effective for unapproved indication 12.87 9.12 6 322113 7912 90298416
Electrocardiogram QRS complex prolonged 12.85 9.12 5 322114 7343 90298985
Urine calcium/creatinine ratio increased 12.85 9.12 7 322112 116 90306212
Middle insomnia 12.85 9.12 25 322094 16726 90289602
Intestinal ischaemia 12.80 9.12 64 322055 8819 90297509
Gastrointestinal toxicity 12.78 9.12 9 322110 9458 90296870
Pharyngotonsillitis 12.77 9.12 8 322111 174 90306154
Cardioactive drug level increased 12.76 9.12 27 322092 2357 90303971
Abnormal loss of weight 12.69 9.12 53 322066 6770 90299558
Flashback 12.69 9.12 10 322109 317 90306011
Prothrombin time ratio increased 12.64 9.12 7 322112 120 90306208
Dermatitis atopic 12.61 9.12 42 322077 23430 90282898
Therapeutic response unexpected 12.56 9.12 38 322081 21842 90284486
Scratch 12.52 9.12 10 322109 9856 90296472
Septic shock 12.49 9.12 217 321902 83943 90222385
Acute myeloid leukaemia 12.46 9.12 35 322084 20605 90285723
Documented hypersensitivity to administered product 12.45 9.12 14 322105 700 90305628
Oropharyngeal swelling 12.43 9.12 16 322103 922 90305406
Gastrointestinal haemorrhage 12.41 9.12 414 321705 89834 90216494
Renal function test abnormal 12.40 9.12 5 322114 7186 90299142
Protein-losing gastroenteropathy 12.39 9.12 10 322109 328 90306000
Urinary straining 12.37 9.12 5 322114 40 90306288
Nasal oedema 12.34 9.12 4 322115 6580 90299748
Chronic fatigue syndrome 12.32 9.12 21 322098 1558 90304770
Neutrophil count 12.28 9.12 11 322108 417 90305911
Acute coronary syndrome 12.27 9.12 73 322046 10740 90295588
Biopsy muscle abnormal 12.27 9.12 5 322114 41 90306287
Vulvovaginal candidiasis 12.22 9.12 36 322083 3864 90302464
Pneumonia aspiration 12.19 9.12 209 321910 40731 90265597
Device dependence 12.19 9.12 4 322115 16 90306312
Pneumocystis jirovecii pneumonia 12.19 9.12 124 321995 21492 90284836
Affect lability 12.16 9.12 29 322090 18034 90288294
Mouth swelling 12.15 9.12 46 322073 5616 90300712
Nausea 12.12 9.12 3643 318476 1106673 89199655
Depression 12.11 9.12 1233 320886 299368 90006960
Rales 12.11 9.12 97 322022 15730 90290598
Unintended pregnancy 12.09 9.12 6 322113 7631 90298697
Bronchiectasis 12.07 9.12 127 321992 22203 90284125
Muscle spasms 12.07 9.12 1046 321073 250837 90055491
Blindness 12.05 9.12 146 321973 26422 90279906
Picornavirus infection 12.04 9.12 6 322113 82 90306246
Enterocolitis 12.02 9.12 71 322048 10419 90295909
Subendocardial ischaemia 11.97 9.12 6 322113 83 90306245
Weight fluctuation 11.97 9.12 115 322004 19634 90286694
Hepatic cirrhosis 11.96 9.12 302 321817 62951 90243377
Hepatic enzyme 11.96 9.12 44 322075 5300 90301028
Toxic epidermal necrolysis 11.94 9.12 172 321947 32356 90273972
Aspartate aminotransferase abnormal 11.93 9.12 28 322091 2621 90303707
Neoplasm malignant 11.91 9.12 71 322048 33809 90272519
Mediastinitis 11.91 9.12 10 322109 347 90305981
Influenza like illness 11.91 9.12 208 321911 80403 90225925
Haemodialysis 11.89 9.12 62 322057 8685 90297643
Multiple drug therapy 11.88 9.12 5 322114 7004 90299324
Drug level below therapeutic 11.88 9.12 3 322116 5811 90300517
Systemic lupus erythematosus 11.85 9.12 1116 321003 360780 89945548
Cerebral fungal infection 11.84 9.12 9 322110 270 90306058
Catarrh 11.80 9.12 21 322098 1613 90304715
Pancreatic carcinoma recurrent 11.78 9.12 6 322113 86 90306242
Breath sounds abnormal 11.77 9.12 23 322096 15363 90290965
Overweight 11.75 9.12 47 322072 5887 90300441
Ulcer 11.73 9.12 173 321946 32709 90273619
Tooth hypoplasia 11.72 9.12 6 322113 87 90306241
Chronic kidney disease-mineral and bone disorder 11.64 9.12 7 322112 141 90306187
Syncope 11.64 9.12 580 321539 132083 90174245
Thyroid disorder 11.62 9.12 29 322090 17756 90288572
Respiratory arrest 11.61 9.12 70 322049 33241 90273087
Ovarian fibroma 11.49 9.12 6 322113 91 90306237
Cervix inflammation 11.48 9.12 4 322115 20 90306308
Drug interaction 11.43 9.12 1136 320983 275317 90031011
Genitourinary symptom 11.43 9.12 7 322112 146 90306182
Oesophageal food impaction 11.42 9.12 9 322110 285 90306043
Lacunar infarction 11.38 9.12 32 322087 3345 90302983
Complication of device removal 11.37 9.12 4 322115 6251 90300077
Pregnancy 11.37 9.12 295 321824 61752 90244576
Sensitivity to weather change 11.36 9.12 9 322110 8905 90297423
Amenorrhoea 11.34 9.12 15 322104 11707 90294621
Epstein-Barr virus infection 11.33 9.12 12 322107 10332 90295996
Degenerative mitral valve disease 11.32 9.12 4 322115 21 90306307
Ocular hyperaemia 11.28 9.12 72 322047 33726 90272602
Skin oedema 11.27 9.12 17 322102 1137 90305191
Body temperature increased 11.25 9.12 103 322016 44607 90261721
Gastric cancer 11.25 9.12 42 322077 5094 90301234
Skin toxicity 11.23 9.12 5 322114 6774 90299554
Dyspnoea exertional 11.18 9.12 185 321934 72103 90234225
Perforation 11.16 9.12 23 322096 1971 90304357
Poor venous access 11.14 9.12 34 322085 19493 90286835
Pneumonia viral 11.13 9.12 9 322110 8814 90297514
Azotaemia 11.11 9.12 43 322076 5305 90301023
Vaginal cellulitis 11.09 9.12 6 322113 98 90306230
Noninfective gingivitis 11.09 9.12 24 322095 2129 90304199
Hypochloraemia 11.04 9.12 27 322092 2595 90303733
Drug effect less than expected 11.03 9.12 4 322115 6134 90300194
Multiple injuries 11.02 9.12 22 322097 1843 90304485
Hypercholesterolaemia 11.01 9.12 451 321668 100441 90205887
Gallbladder hypofunction 10.98 9.12 11 322108 481 90305847
Spinal operation 10.98 9.12 12 322107 10184 90296144
Immune thrombocytopenia 10.93 9.12 83 322036 13243 90293085
Pharyngeal inflammation 10.91 9.12 16 322103 1044 90305284
Fibrosis 10.89 9.12 46 322073 5906 90300422
Post cardiac arrest syndrome 10.87 9.12 4 322115 24 90306304
Spinal pain 10.86 9.12 25 322094 15742 90290586
Hemiplegia 10.83 9.12 26 322093 16134 90290194
Suicidal ideation 10.78 9.12 191 321928 73664 90232664
Aortic valve replacement 10.76 9.12 15 322104 934 90305394
Dyslalia 10.72 9.12 13 322106 705 90305623
Dialysis 10.70 9.12 73 322046 11256 90295072
Gastroduodenal ulcer 10.68 9.12 10 322109 402 90305926
Large intestine perforation 10.66 9.12 65 322054 9647 90296681
Bronchogenic cyst 10.66 9.12 3 322116 6 90306322
Stevens-Johnson syndrome 10.65 9.12 155 321964 29221 90277107
Rash papulosquamous 10.63 9.12 6 322113 107 90306221
Colon cancer 10.62 9.12 71 322048 10873 90295455
Drug dependence 10.56 9.12 61 322058 29266 90277062
Cholangitis 10.53 9.12 52 322067 7130 90299198
Device leakage 10.49 9.12 12 322107 9979 90296349
Vulval haemorrhage 10.48 9.12 4 322115 27 90306301
Uterine perforation 10.44 9.12 7 322112 7547 90298781
Immune reconstitution inflammatory syndrome 10.40 9.12 6 322113 7013 90299315
Memory impairment 10.39 9.12 825 321294 196419 90109909
Neuroleptic malignant syndrome 10.35 9.12 24 322095 15072 90291256
Blood test abnormal 10.33 9.12 117 322002 20835 90285493
Aortic valve calcification 10.32 9.12 12 322107 622 90305706
Tuberculosis 10.27 9.12 18 322101 12531 90293797
Blood bilirubin abnormal 10.24 9.12 22 322097 1942 90304386
Parosmia 10.23 9.12 51 322068 7018 90299310
Coma 10.23 9.12 189 321930 72443 90233885
Lip oedema 10.22 9.12 38 322081 4601 90301727
Morbid thoughts 10.21 9.12 13 322106 741 90305587
Myocardial ischaemia 10.21 9.12 84 322035 13730 90292598
Respiration abnormal 10.20 9.12 8 322111 7955 90298373
Rash papular 10.19 9.12 114 322005 20241 90286087
Bleeding time prolonged 10.19 9.12 12 322107 631 90305697
Genital pain 10.16 9.12 13 322106 745 90305583
Vitamin B12 deficiency 10.13 9.12 53 322066 7433 90298895
Osteitis 10.13 9.12 33 322086 3740 90302588
Nasal mucosal erosion 10.12 9.12 5 322114 67 90306261
Dilatation atrial 10.11 9.12 22 322097 1959 90304369
Ocular discomfort 10.09 9.12 5 322114 6365 90299963
Feeling jittery 10.09 9.12 25 322094 15346 90290982
Urinary tract infection 10.07 9.12 942 321177 304690 90001638
Cyst 10.06 9.12 28 322091 16533 90289795
Lymphadenopathy 10.04 9.12 109 322010 45666 90260662
Gambling 10.03 9.12 8 322111 258 90306070
Tuberculous pleurisy 10.02 9.12 10 322109 435 90305893
Superinfection 10.01 9.12 29 322090 3083 90303245
Motor dysfunction 9.93 9.12 35 322084 19195 90287133
Skin burning sensation 9.92 9.12 36 322083 19575 90286753
Duodenal ulcer 9.90 9.12 63 322056 9489 90296839
Blood creatinine increased 9.90 9.12 448 321671 100938 90205390
Aortic aneurysm rupture 9.88 9.12 11 322108 544 90305784
Incorrect dose administered by device 9.88 9.12 4 322115 5733 90300595
Product adhesion issue 9.86 9.12 3 322116 5139 90301189
Ileus 9.86 9.12 96 322023 16450 90289878
Thyroid cancer 9.85 9.12 5 322114 6279 90300049
Disturbance in attention 9.83 9.12 228 321891 46881 90259447
Hyperacusis 9.83 9.12 27 322092 2784 90303544
Underdose 9.81 9.12 134 321985 53883 90252445
Blood triglycerides increased 9.81 9.12 83 322036 13678 90292650
Pericarditis 9.75 9.12 1100 321019 269051 90037277
Ankylosing spondylitis 9.73 9.12 20 322099 13113 90293215
Renal cyst haemorrhage 9.68 9.12 5 322114 74 90306254
Burn oral cavity 9.66 9.12 7 322112 195 90306133
Paranasal sinus discomfort 9.65 9.12 5 322114 6205 90300123
Genital haemorrhage 9.64 9.12 10 322109 8692 90297636
Pregnancy with contraceptive device 9.63 9.12 3 322116 5063 90301265
Solar lentigo 9.62 9.12 16 322103 1164 90305164
Dysuria 9.60 9.12 195 321924 39206 90267122
Femoral hernia 9.59 9.12 4 322115 35 90306293
Blood pressure fluctuation 9.53 9.12 130 321989 52283 90254045
Embolic stroke 9.51 9.12 34 322085 4038 90302290
Gastrointestinal amyloidosis 9.50 9.12 5 322114 77 90306251
Atypical fracture 9.50 9.12 14 322105 917 90305411
Vision blurred 9.50 9.12 309 321810 109984 90196344
Clonus 9.42 9.12 43 322076 5707 90300621
Breast pain 9.41 9.12 14 322105 10404 90295924
Dry eye 9.37 9.12 147 321972 57784 90248544
Gastroenteritis 9.36 9.12 151 321968 29078 90277250
Myocardial necrosis 9.36 9.12 7 322112 205 90306123
Second primary malignancy 9.32 9.12 14 322105 10364 90295964
Aortitis 9.30 9.12 17 322102 1333 90304995
Parkinsonian gait 9.30 9.12 11 322108 581 90305747
Gastrointestinal stoma output decreased 9.24 9.12 6 322113 139 90306189
Drug specific antibody present 9.24 9.12 4 322115 5510 90300818
Product quality issue 9.22 9.12 213 321906 79112 90227216
Orthostatic hypotension 9.22 9.12 204 321915 41623 90264705
Colitis ulcerative 9.21 9.12 280 321839 59986 90246342
Uraemic encephalopathy 9.21 9.12 8 322111 291 90306037
Pyelonephritis acute 9.19 9.12 41 322078 5391 90300937
Phyllodes tumour 9.17 9.12 5 322114 83 90306245
Subdural haematoma 9.16 9.12 95 322024 16550 90289778
Pleurisy viral 9.14 9.12 3 322116 12 90306316
Obstructive nephropathy 9.14 9.12 3 322116 12 90306316
Akathisia 9.14 9.12 16 322103 11143 90295185
Cystitis noninfective 9.13 9.12 17 322102 1352 90304976
Amniotic fluid index decreased 9.12 9.12 4 322115 40 90306288
Catheter site erythema 9.12 9.12 3 322116 4891 90301437

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 593.90 10.22 979 166312 629218 41824826
Chronic kidney disease 471.90 10.22 741 166550 46500 42407544
Death 352.74 10.22 836 166455 470349 41983695
Colitis microscopic 299.42 10.22 174 167117 2959 42451085
Completed suicide 240.26 10.22 44 167247 96421 42357623
Hyponatraemia 236.08 10.22 904 166387 100558 42353486
End stage renal disease 220.96 10.22 298 166993 16260 42437784
Toxicity to various agents 206.98 10.22 364 166927 228772 42225272
Interstitial lung disease 203.36 10.22 724 166567 77738 42376306
Off label use 183.22 10.22 1616 165675 636719 41817325
Drug abuse 165.92 10.22 103 167188 104668 42349376
Product dose omission issue 164.48 10.22 219 167072 154146 42299898
Appendicolith 152.55 10.22 224 167067 13232 42440812
Renal injury 145.88 10.22 209 167082 12071 42441973
Treatment failure 142.71 10.22 35 167256 62589 42391455
Drug dispensed to wrong patient 135.16 10.22 57 167234 460 42453584
Lip swelling 130.23 10.22 253 167038 18800 42435244
Appendicitis 119.88 10.22 256 167035 20357 42433687
Cardiospasm 119.41 10.22 81 167210 1826 42452218
Lower respiratory tract infection 113.41 10.22 388 166903 40818 42413226
Acute kidney injury 103.62 10.22 2019 165272 365318 42088726
Palmoplantar keratoderma 100.64 10.22 78 167213 2176 42451868
Foetal exposure during pregnancy 99.28 10.22 31 167260 47280 42406764
Pruritus genital 98.03 10.22 82 167209 2557 42451487
Tension headache 96.74 10.22 91 167200 3323 42450721
Cerebral infarction 91.53 10.22 300 166991 30869 42423175
Drug resistance 91.10 10.22 13 167278 34235 42419809
Sleep terror 88.73 10.22 81 167210 2845 42451199
Cholestasis 87.34 10.22 306 166985 32573 42421471
Ventricular fibrillation 84.07 10.22 285 167006 29838 42424206
Disease progression 82.60 10.22 288 167003 143368 42310676
Intentional overdose 80.85 10.22 51 167240 51405 42402639
Stress 80.03 10.22 365 166926 43847 42410197
Nephrogenic anaemia 79.22 10.22 72 167219 2514 42451530
Atrial tachycardia 78.62 10.22 89 167202 4051 42449993
Fatigue 77.42 10.22 1224 166067 434417 42019627
Hepatic function abnormal 77.06 10.22 403 166888 51164 42402880
Immunisation 75.37 10.22 52 167239 1206 42452838
Blood phosphorus increased 72.18 10.22 155 167136 12370 42441674
Facial pain 71.58 10.22 86 167205 4174 42449870
Neutropenic sepsis 70.67 10.22 178 167113 15768 42438276
Suicide attempt 70.64 10.22 47 167244 46053 42407991
Product use in unapproved indication 69.19 10.22 432 166859 184024 42270020
Carotid artery occlusion 67.75 10.22 83 167208 4111 42449933
Subacute cutaneous lupus erythematosus 67.54 10.22 52 167239 1436 42452608
Hospitalisation 67.03 10.22 118 167173 74212 42379832
Venous pressure jugular increased 66.25 10.22 40 167251 732 42453312
Tubulointerstitial nephritis 65.15 10.22 271 167020 31277 42422767
Malaise 65.10 10.22 1182 166109 210974 42243070
Rectal haemorrhage 62.99 10.22 371 166920 49235 42404809
Angioedema 62.80 10.22 331 166960 42146 42411898
Hypergastrinaemia 62.72 10.22 26 167265 200 42453844
Hypomagnesaemia 62.22 10.22 249 167042 28239 42425805
Therapeutic product effect incomplete 60.95 10.22 116 167175 70823 42383221
Agranulocytosis 60.91 10.22 260 167031 30352 42423692
Drug ineffective for unapproved indication 60.67 10.22 55 167236 46108 42407936
Antimicrobial susceptibility test resistant 60.36 10.22 30 167261 366 42453678
Minimum inhibitory concentration 58.57 10.22 23 167268 151 42453893
Injection site pain 57.50 10.22 86 167205 57712 42396332
Abdominal distension 56.66 10.22 478 166813 71257 42382787
Hypertensive nephropathy 56.58 10.22 31 167260 468 42453576
Eosinophil count decreased 56.53 10.22 70 167221 3506 42450538
Palpitations 56.39 10.22 367 166924 50430 42403614
Transient ischaemic attack 56.26 10.22 272 167019 33467 42420577
Ascites 56.07 10.22 398 166893 56280 42397764
Weight increased 55.84 10.22 226 167065 107757 42346287
Anosmia 55.56 10.22 84 167207 5092 42448952
Blood uric acid increased 55.28 10.22 160 167131 15387 42438657
Toxic epidermal necrolysis 53.84 10.22 228 167063 26522 42427522
Wrong patient received product 53.24 10.22 68 167223 3515 42450529
Liver function test abnormal 52.48 10.22 259 167032 32132 42421912
Tinnitus 52.43 10.22 239 167052 28699 42425345
Adrenal suppression 51.12 10.22 37 167254 928 42453116
Therapy partial responder 50.10 10.22 9 167282 20012 42434032
Confusional state 49.36 10.22 928 166363 166669 42287375
Haematemesis 49.31 10.22 242 167049 29957 42424087
Gingival disorder 48.56 10.22 44 167247 1530 42452514
Myasthenia gravis 47.98 10.22 156 167135 15981 42438063
Nasopharyngitis 47.83 10.22 169 167122 83827 42370217
Gastric polyps 47.23 10.22 45 167246 1670 42452374
Pain of skin 46.57 10.22 100 167191 7980 42446064
Bronchiectasis 46.38 10.22 166 167125 17853 42436191
Subarachnoid haemorrhage 45.85 10.22 143 167148 14329 42439715
Aplastic anaemia 45.54 10.22 129 167162 12255 42441789
Hypoparathyroidism secondary 45.16 10.22 20 167271 184 42453860
Hepatic cytolysis 43.74 10.22 215 167076 26629 42427415
Therapeutic response delayed 43.74 10.22 30 167261 689 42453355
Central nervous system mass 43.65 10.22 32 167259 819 42453225
Swollen tongue 43.53 10.22 182 167109 21049 42432995
Wall motion score index abnormal 43.52 10.22 32 167259 823 42453221
Abdominal pain 42.87 10.22 1014 166277 189457 42264587
Blood cholesterol increased 42.74 10.22 213 167078 26528 42427516
Therapy non-responder 42.63 10.22 91 167200 53268 42400776
Eosinophilia 42.37 10.22 247 167044 32652 42421392
Airway remodelling 42.05 10.22 32 167259 868 42453176
Melaena 41.82 10.22 278 167013 38468 42415576
Muscle twitching 41.66 10.22 121 167170 11659 42442385
Terminal insomnia 41.46 10.22 32 167259 887 42453157
Analgesic therapy 41.41 10.22 84 167207 6440 42447604
Cardiac murmur 41.18 10.22 127 167164 12648 42441396
Renal impairment 40.65 10.22 633 166658 109595 42344449
Protein-losing gastroenteropathy 40.64 10.22 24 167267 421 42453623
Rash papular 40.51 10.22 120 167171 11691 42442353
Pericarditis 40.00 10.22 130 167161 13314 42440730
Accidental exposure to product 39.94 10.22 15 167276 20378 42433666
Gastrointestinal polyp haemorrhage 39.90 10.22 25 167266 490 42453554
Atopy 39.79 10.22 32 167259 943 42453101
Sleep disorder therapy 39.36 10.22 85 167206 6809 42447235
Therapeutic response shortened 38.86 10.22 4 167287 13550 42440494
Therapeutic product effect decreased 38.22 10.22 59 167232 39091 42414953
Vomiting 38.15 10.22 1443 165848 288280 42165764
Cardiac septal defect 38.10 10.22 31 167260 929 42453115
Cardiogenic shock 37.44 10.22 254 167037 35386 42418658
Haemorrhage subcutaneous 37.41 10.22 49 167242 2597 42451447
Catarrh 36.72 10.22 76 167215 5910 42448134
Migraine 36.16 10.22 196 167095 25218 42428826
Gingival pain 35.76 10.22 93 167198 8401 42445643
Occupational dermatitis 35.64 10.22 14 167277 92 42453952
Jaundice 35.43 10.22 245 167046 34344 42419700
Medication error 35.25 10.22 237 167054 32917 42421127
Tetanus 34.11 10.22 12 167279 55 42453989
Eosinophilic myocarditis 34.02 10.22 34 167257 1339 42452705
Hyperphosphataemia 33.64 10.22 120 167171 12884 42441160
Burns second degree 33.48 10.22 74 167217 6022 42448022
Drug dependence 33.31 10.22 39 167252 29055 42424989
Synovitis 33.01 10.22 10 167281 15557 42438487
Hypocalcaemia 32.27 10.22 216 167075 29957 42424087
Device dependence 32.26 10.22 11 167280 45 42453999
Parosmia 32.16 10.22 84 167207 7607 42446437
Chronic kidney disease-mineral and bone disorder 32.13 10.22 21 167270 444 42453600
Poisoning 31.98 10.22 9 167282 14690 42439354
Liver disorder 31.73 10.22 265 167026 39379 42414665
Hepatocellular injury 31.29 10.22 179 167112 23499 42430545
Full blood count abnormal 31.14 10.22 43 167248 29833 42424211
Pancreatitis acute 31.06 10.22 232 167059 33332 42420712
Blood pressure fluctuation 30.88 10.22 36 167255 26872 42427172
Overdose 30.54 10.22 265 167026 104999 42349045
Ventricular tachycardia 30.52 10.22 213 167078 29947 42424097
Nephropathy 30.47 10.22 77 167214 6834 42447210
Drug therapy 30.15 10.22 73 167218 6307 42447737
Amnesia 30.06 10.22 203 167088 28234 42425810
Gait disturbance 29.65 10.22 244 167047 97756 42356288
Diabetic nephropathy 29.51 10.22 41 167250 2300 42451744
Injection site warmth 29.45 10.22 44 167247 2639 42451405
Iron deficiency 29.41 10.22 103 167188 10958 42443086
Activated partial thromboplastin time prolonged 29.29 10.22 132 167159 15771 42438273
Influenza 29.15 10.22 135 167156 62040 42392004
Drug eruption 28.91 10.22 172 167119 22903 42431141
Idiopathic pulmonary fibrosis 28.89 10.22 59 167232 4545 42449499
Therapy interrupted 28.65 10.22 27 167264 22223 42431821
Incorrect dose administered 28.56 10.22 109 167182 52865 42401179
Systemic lupus erythematosus 28.50 10.22 91 167200 9233 42444811
Gastric cancer 28.46 10.22 75 167216 6828 42447216
Hypopnoea 27.91 10.22 81 167210 7801 42446243
Sedation 27.80 10.22 48 167243 30427 42423617
Rash vesicular 27.69 10.22 48 167243 3265 42450779
Steroid dependence 27.68 10.22 73 167218 6649 42447395
Myelosuppression 27.57 10.22 75 167216 40386 42413658
Marasmus 27.48 10.22 25 167266 874 42453170
Hepatitis cholestatic 27.45 10.22 93 167198 9731 42444313
Administration site inflammation 27.40 10.22 10 167281 52 42453992
Haematotoxicity 27.35 10.22 5 167286 10980 42443064
Diplopia 27.12 10.22 154 167137 20162 42433882
Unevaluable event 26.95 10.22 59 167232 34229 42419815
Increased viscosity of upper respiratory secretion 26.83 10.22 17 167274 340 42453704
Infusion related reaction 26.78 10.22 135 167156 60671 42393373
Neuroendocrine tumour 26.62 10.22 25 167266 911 42453133
Pneumonia aspiration 26.48 10.22 307 166984 49771 42404273
Neutrophil count decreased 26.43 10.22 372 166919 63043 42391001
Eosinophilic oesophagitis 26.19 10.22 22 167269 690 42453354
Hypoacusis 26.13 10.22 21 167270 18681 42435363
Therapy cessation 26.11 10.22 25 167266 20425 42433619
Psoriatic arthropathy 25.96 10.22 36 167255 24931 42429113
Aspergillus infection 25.84 10.22 15 167276 15822 42438222
Microangiopathy 25.11 10.22 32 167259 1650 42452394
Rheumatoid arthritis 25.09 10.22 84 167207 42356 42411688
Renal disorder 24.97 10.22 197 167094 28783 42425261
Faecal vomiting 24.67 10.22 21 167270 671 42453373
Tetany 24.38 10.22 26 167265 1106 42452938
Subdural haematoma 24.35 10.22 165 167126 22973 42431071
Product use issue 24.18 10.22 189 167102 76562 42377482
Asthenia 23.98 10.22 881 166410 279912 42174132
Inappropriate schedule of product administration 23.75 10.22 251 167040 95651 42358393
Wrong technique in product usage process 23.45 10.22 87 167204 42548 42411496
Hepatitis acute 23.37 10.22 83 167208 8892 42445152
Occupational exposure to air contaminants 23.21 10.22 12 167279 160 42453884
Drug reaction with eosinophilia and systemic symptoms 23.17 10.22 260 167031 41815 42412229
Pathogen resistance 23.14 10.22 8 167283 11442 42442602
Femoral neck fracture 23.01 10.22 51 167240 4158 42449886
Chest pain 22.85 10.22 713 166578 138817 42315227
Essential thrombocythaemia 22.82 10.22 12 167279 166 42453878
Therapeutic response decreased 22.75 10.22 72 167219 36940 42417104
Neuropathy peripheral 22.69 10.22 273 167018 101580 42352464
Constipation 22.68 10.22 814 166477 161477 42292567
Poisoning deliberate 22.43 10.22 6 167285 10128 42443916
Pneumonia bacterial 22.31 10.22 121 167170 15571 42438473
Melanoderma 21.91 10.22 12 167279 181 42453863
Eosinophil count increased 21.86 10.22 92 167199 10671 42443373
Neurotoxicity 21.81 10.22 37 167254 23614 42430430
Weight decreased 21.64 10.22 636 166655 207312 42246732
Localised infection 21.56 10.22 29 167262 20344 42433700
Hyperchlorhydria 21.50 10.22 19 167272 639 42453405
Dermatitis atopic 21.33 10.22 11 167280 12393 42441651
Prostatic specific antigen increased 21.25 10.22 21 167270 16904 42437140
Hypophosphataemia 21.24 10.22 148 167143 20797 42433247
Aortic stenosis 21.18 10.22 79 167212 8666 42445378
Eosinophilic pneumonia 21.17 10.22 54 167237 4820 42449224
Laboratory test abnormal 21.14 10.22 36 167255 22942 42431102
Dehydration 21.03 10.22 716 166575 141051 42312993
Cystitis escherichia 20.96 10.22 12 167279 198 42453846
Orthostatic hypotension 20.68 10.22 197 167094 30373 42423671
Immune reconstitution inflammatory syndrome 20.65 10.22 7 167284 10136 42443908
No adverse event 20.58 10.22 81 167210 38940 42415104
Disseminated intravascular coagulation 20.51 10.22 167 167124 24627 42429417
Nightmare 20.44 10.22 168 167123 24844 42429200
Thrombotic cerebral infarction 20.44 10.22 16 167275 453 42453591
Hypozincaemia 20.40 10.22 6 167285 13 42454031
Prostate tenderness 20.31 10.22 8 167283 53 42453991
Coma 20.25 10.22 125 167166 53429 42400615
Rash maculo-papular 19.87 10.22 230 167061 37273 42416771
Premature baby 19.75 10.22 38 167253 23115 42430929
Enteritis infectious 19.72 10.22 28 167263 1603 42452441
Device malfunction 19.66 10.22 12 167279 12315 42441729
Rhinitis 19.56 10.22 96 167195 11881 42442163
Oral disorder 19.55 10.22 52 167239 4760 42449284
Ocular myasthenia 19.53 10.22 17 167274 560 42453484
Alcoholic liver disease 19.53 10.22 17 167274 560 42453484
Upper respiratory tract inflammation 19.27 10.22 30 167261 1866 42452178
Hypotension 19.24 10.22 821 166470 256810 42197234
Total lung capacity decreased 19.23 10.22 43 167248 3527 42450517
Incorrect route of product administration 19.20 10.22 162 167129 24143 42429901
Blood magnesium decreased 18.89 10.22 70 167221 7656 42446388
Sinobronchitis 18.80 10.22 5 167286 6 42454038
Gastric varices 18.80 10.22 18 167273 672 42453372
Enterochromaffin cell hyperplasia 18.78 10.22 6 167285 19 42454025
Dry mouth 18.70 10.22 239 167052 39640 42414404
Rebound acid hypersecretion 18.69 10.22 9 167282 102 42453942
Blood alkaline phosphatase increased 18.68 10.22 208 167083 33389 42420655
Hallucination 18.50 10.22 323 166968 57184 42396860
Pelvic pain 18.44 10.22 40 167251 3214 42450830
Cytokine release syndrome 18.40 10.22 101 167190 44426 42409618
Mouth ulceration 18.40 10.22 111 167180 14852 42439192
Alveolitis 18.25 10.22 29 167262 1836 42452208
Paraesthesia oral 18.22 10.22 53 167238 5110 42448934
Oesophagitis 18.05 10.22 112 167179 15135 42438909
Alcohol poisoning 18.00 10.22 68 167223 7506 42446538
Device leakage 17.87 10.22 9 167282 10276 42443768
Failure to anastomose 17.81 10.22 11 167280 210 42453834
Radiation pneumonitis 17.71 10.22 37 167254 2896 42451148
Pseudocellulitis 17.67 10.22 12 167279 271 42453773
Eye pruritus 17.60 10.22 90 167201 11322 42442722
Cholangitis 17.53 10.22 86 167205 10641 42443403
Iron deficiency anaemia 17.51 10.22 99 167192 12940 42441104
Intracranial haematoma 17.45 10.22 16 167275 565 42453479
Post transplant lymphoproliferative disorder 17.38 10.22 7 167284 9113 42444931
Full blood count decreased 17.32 10.22 34 167257 20526 42433518
Blood pressure increased 17.12 10.22 289 167002 101639 42352405
Toxic skin eruption 16.98 10.22 102 167189 13628 42440416
Lung opacity 16.96 10.22 56 167235 5781 42448263
Respiratory depression 16.95 10.22 30 167261 18838 42435206
Vasculitis 16.93 10.22 127 167164 18267 42435777
Akathisia 16.91 10.22 10 167281 10441 42443603
Cardio-respiratory arrest 16.83 10.22 148 167143 58488 42395556
Abdominal pain upper 16.81 10.22 434 166857 82175 42371869
Haemorrhagic cerebral infarction 16.66 10.22 19 167272 872 42453172
Pulmonary thrombosis 16.58 10.22 6 167285 8342 42445702
Miosis 16.52 10.22 17 167274 13429 42440615
Hiatus hernia 16.48 10.22 72 167219 8488 42445556
Multiple sclerosis relapse 16.46 10.22 19 167272 14245 42439799
Impaired work ability 16.36 10.22 92 167199 11999 42442045
Chills 16.36 10.22 265 167026 93801 42360243
Renal failure 16.34 10.22 705 166586 143021 42311023
Genital pain 16.33 10.22 19 167272 891 42453153
Circulatory collapse 16.33 10.22 153 167138 23483 42430561
Erythema multiforme 16.31 10.22 80 167211 9897 42444147
Pain 16.30 10.22 790 166501 244058 42209986
Vasculitic rash 16.08 10.22 20 167271 1006 42453038
Gastrooesophageal reflux disease 15.99 10.22 257 167034 44766 42409278
Adverse event 15.97 10.22 44 167247 23596 42430448
Transplant rejection 15.79 10.22 18 167273 13570 42440474
Hypoaesthesia 15.74 10.22 192 167099 71271 42382773
Hyperlipidaemia 15.74 10.22 141 167150 21375 42432669
Nasal congestion 15.71 10.22 61 167230 29440 42424604
Inappropriate antidiuretic hormone secretion 15.68 10.22 115 167176 16426 42437618
Device issue 15.58 10.22 18 167273 13491 42440553
Delusion 15.56 10.22 21 167270 14713 42439331
Drug intolerance 15.55 10.22 222 167069 80202 42373842
Hospice care 15.48 10.22 7 167284 8506 42445538
Colitis ulcerative 15.45 10.22 164 167127 26011 42428033
Intentional dose omission 15.40 10.22 8 167283 8978 42445066
Acute graft versus host disease in skin 15.33 10.22 5 167286 7419 42446625
Glomerulosclerosis 15.27 10.22 18 167273 856 42453188
Abulia 15.13 10.22 16 167275 674 42453370
Diabetes mellitus 15.08 10.22 325 166966 59762 42394282
Mental status changes 15.06 10.22 100 167191 42015 42412029
Eczema 15.03 10.22 202 167089 33884 42420160
Rash morbilliform 15.01 10.22 43 167248 4110 42449934
Follicular mucinosis 14.95 10.22 5 167286 19 42454025
Renal artery stenosis 14.90 10.22 30 167261 2287 42451757
Cerebral haemorrhage 14.82 10.22 225 167066 38741 42415303
Epstein-Barr virus infection 14.76 10.22 10 167281 9708 42444336
Renal haemangioma 14.75 10.22 5 167286 20 42454024
Treatment noncompliance 14.73 10.22 87 167204 37585 42416459
Platelet count decreased 14.71 10.22 675 166616 137906 42316138
Swelling face 14.60 10.22 169 167122 27385 42426659
Acute graft versus host disease 14.55 10.22 7 167284 8208 42445836
Gastric ulcer haemorrhage 14.55 10.22 55 167236 6072 42447972
Respiratory muscle weakness 14.53 10.22 8 167283 122 42453922
Chronic graft versus host disease 14.46 10.22 3 167288 6022 42448022
Venous thrombosis limb 14.44 10.22 30 167261 2339 42451705
Hypoxia 14.44 10.22 190 167101 69596 42384448
Mucormycosis 14.42 10.22 5 167286 7138 42446906
Enterocolitis 14.41 10.22 77 167214 9852 42444192
Upper gastrointestinal haemorrhage 14.38 10.22 182 167109 30117 42423927
Lymphocyte stimulation test positive 14.32 10.22 15 167276 625 42453419
Duodenal polyp 14.31 10.22 11 167280 303 42453741
Immune thrombocytopenia 14.30 10.22 84 167207 11132 42442912
Nephrosclerosis 14.20 10.22 19 167272 1028 42453016
Diffuse vasculitis 14.11 10.22 7 167284 85 42453959
Barrett's oesophagus 14.11 10.22 12 167279 383 42453661
Mobility decreased 14.09 10.22 81 167210 35225 42418819
Neutrophil count increased 14.08 10.22 129 167162 19675 42434369
Serotonin syndrome 14.04 10.22 53 167238 25792 42428252
Gastrointestinal ulcer 14.03 10.22 26 167265 1864 42452180
Crohn's disease 13.95 10.22 34 167257 2950 42451094
Polyneuropathy 13.94 10.22 33 167258 18628 42435416
Neuralgia 13.90 10.22 158 167133 25489 42428555
Renal atrophy 13.73 10.22 21 167270 1286 42452758
Contraindication to medical treatment 13.58 10.22 17 167274 861 42453183
Ejection fraction decreased 13.55 10.22 43 167248 22044 42432000
Product dose omission in error 13.51 10.22 8 167283 8346 42445698
Renal hypertension 13.44 10.22 10 167281 262 42453782
Gastrostomy tube site complication 13.43 10.22 7 167284 95 42453949
Hypovitaminosis 13.42 10.22 16 167275 770 42453274
BK virus infection 13.39 10.22 9 167282 8775 42445269
Dermatitis acneiform 13.34 10.22 63 167228 7676 42446368
Therapeutic response unexpected 13.31 10.22 15 167276 11366 42442678
Blindness 13.24 10.22 118 167173 17860 42436184
Thalamus haemorrhage 13.22 10.22 19 167272 1100 42452944
Sopor 13.22 10.22 93 167198 13109 42440935
Nephropathy toxic 13.21 10.22 29 167262 16809 42437235
Gastrointestinal infection 13.14 10.22 5 167286 6738 42447306
Periprosthetic fracture 13.03 10.22 9 167282 209 42453835
Neurological symptom 13.01 10.22 12 167279 9979 42444065
Burning feet syndrome 12.93 10.22 7 167284 103 42453941
Heart rate decreased 12.93 10.22 87 167204 36445 42417599
Biliary sepsis 12.89 10.22 17 167274 907 42453137
Infection 12.86 10.22 338 166953 111730 42342314
Anal spasm 12.85 10.22 8 167283 155 42453889
Gastritis 12.74 10.22 147 167144 23800 42430244
Anticoagulant therapy 12.73 10.22 43 167248 4492 42449552
Procedural failure 12.70 10.22 6 167285 65 42453979
Oesophagogastric fundoplasty 12.68 10.22 4 167287 12 42454032
Purpura 12.67 10.22 85 167206 11794 42442250
Retinal vascular occlusion 12.63 10.22 9 167282 220 42453824
Septic embolus 12.60 10.22 21 167270 1384 42452660
Skin toxicity 12.52 10.22 5 167286 6544 42447500
Wrong product administered 12.47 10.22 53 167238 6173 42447871
Pelvic cyst 12.46 10.22 5 167286 35 42454009
Carotid bruit 12.45 10.22 8 167283 164 42453880
Haematuria 12.45 10.22 306 166985 57493 42396551
Substance abuse 12.44 10.22 10 167281 8895 42445149
Back disorder 12.43 10.22 7 167284 7507 42446537
Mesenteric artery embolism 12.38 10.22 6 167285 69 42453975
Blood albumin decreased 12.34 10.22 103 167188 15299 42438745
Dialysis 12.33 10.22 85 167206 11901 42442143
Hyperaesthesia 12.30 10.22 4 167287 5948 42448096
Myocardial ischaemia 12.28 10.22 115 167176 17647 42436397
Faeces discoloured 12.19 10.22 111 167180 16903 42437141
Night sweats 12.16 10.22 39 167252 19930 42434114
Nasal polyps 12.15 10.22 38 167253 3813 42450231
Chronic sinusitis 12.14 10.22 35 167256 3357 42450687
N-telopeptide urine increased 12.11 10.22 5 167286 38 42454006
Drug dose omission by device 12.09 10.22 4 167287 5882 42448162
Central nervous system lesion 12.08 10.22 8 167283 7862 42446182
Renal cyst 12.04 10.22 74 167217 9965 42444079
Cystitis 12.03 10.22 17 167274 11681 42442363
Discoloured vomit 12.02 10.22 15 167276 757 42453287
Gastric ulcer 12.01 10.22 117 167174 18145 42435899
Blood gastrin increased 12.00 10.22 5 167286 39 42454005
Sterile pyuria 12.00 10.22 5 167286 39 42454005
Pyelonephritis 11.92 10.22 62 167229 7852 42446192
Electrocardiogram QRS complex prolonged 11.89 10.22 4 167287 5819 42448225
Enterococcal infection 11.88 10.22 18 167273 12021 42442023
Small for dates baby 11.87 10.22 3 167288 5260 42448784
Cardiac failure congestive 11.81 10.22 251 167040 85351 42368693
Generalised onset non-motor seizure 11.80 10.22 4 167287 16 42454028
Dressler's syndrome 11.80 10.22 4 167287 16 42454028
Blood pressure systolic increased 11.80 10.22 63 167228 27905 42426139
Spinal cord haemorrhage 11.76 10.22 10 167281 319 42453725
Cytomegalovirus infection reactivation 11.74 10.22 16 167275 11162 42442882
Blood immunoglobulin E increased 11.65 10.22 36 167255 3589 42450455
Hyperuricaemia 11.64 10.22 70 167221 9354 42444690
Rhinorrhoea 11.61 10.22 75 167216 31719 42422325
Bacteroides infection 11.59 10.22 29 167262 2558 42451486
Hip fracture 11.59 10.22 22 167269 13450 42440594
Hepatotoxicity 11.58 10.22 55 167236 25112 42428932
Jaundice cholestatic 11.53 10.22 46 167245 5207 42448837
COVID-19 11.46 10.22 357 166934 115591 42338453
Macroglossia 11.45 10.22 12 167279 500 42453544
Gastrointestinal tract irritation 11.45 10.22 10 167281 331 42453713
Pure white cell aplasia 11.41 10.22 6 167285 83 42453961
Campylobacter test positive 11.41 10.22 6 167285 83 42453961
Angina pectoris 11.39 10.22 187 167104 32709 42421335
Cough 11.38 10.22 577 166714 177526 42276518
Adrenal insufficiency 11.37 10.22 119 167172 18805 42435239
Non-small cell lung cancer 11.28 10.22 44 167247 4930 42449114
Cerebellar infarction 11.26 10.22 26 167265 2179 42451865
Blood calcium increased 11.23 10.22 64 167227 8390 42445654
Illness 11.17 10.22 55 167236 24875 42429169
Endoscopy upper gastrointestinal tract 11.11 10.22 5 167286 48 42453996
Reflux gastritis 11.10 10.22 10 167281 345 42453699
Oculocephalogyric reflex absent 11.09 10.22 4 167287 20 42454024
Meniere's disease 11.02 10.22 5 167286 49 42453995
Mesothelioma 10.99 10.22 11 167280 434 42453610
Cerebral hyperperfusion syndrome 10.98 10.22 6 167285 90 42453954
Gastric varices haemorrhage 10.97 10.22 9 167282 273 42453771
Dyslalia 10.97 10.22 13 167278 622 42453422
Lip blister 10.93 10.22 15 167276 832 42453212
Kidney infection 10.87 10.22 54 167237 6716 42447328
Tachypnoea 10.77 10.22 46 167245 21616 42432428
Exposed bone in jaw 10.73 10.22 21 167270 1568 42452476
Renal pain 10.72 10.22 35 167256 3592 42450452
White blood cell count increased 10.72 10.22 242 167049 44845 42409199
Device dislocation 10.68 10.22 9 167282 7822 42446222
Self-injurious ideation 10.63 10.22 23 167268 1845 42452199
Osteonecrosis of jaw 10.62 10.22 118 167173 18931 42435113
Carboxyhaemoglobin increased 10.59 10.22 5 167286 54 42453990
Atypical haemolytic uraemic syndrome 10.58 10.22 12 167279 547 42453497
Inhibitory drug interaction 10.58 10.22 23 167268 1851 42452193
Tendon discomfort 10.52 10.22 10 167281 370 42453674
Immobilisation syndrome 10.37 10.22 11 167280 465 42453579
Embolic cerebral infarction 10.37 10.22 15 167276 874 42453170
Hyperkalaemia 10.36 10.22 400 166891 80058 42373986
Aortic dissection 10.33 10.22 31 167260 3041 42451003
Paranoia 10.32 10.22 25 167266 14001 42440043
Acne 10.29 10.22 24 167267 13620 42440424
Cataract 10.28 10.22 74 167217 30530 42423514
Hypocoagulable state 10.25 10.22 16 167275 997 42453047
Bacterial infection 10.22 10.22 160 167131 27719 42426325

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 1194.62 9.55 2572 425133 1517968 108643626
Colitis microscopic 792.03 9.55 546 427159 12848 110148746
Completed suicide 646.83 9.55 86 427619 242295 109919299
Hyponatraemia 523.79 9.55 1941 425764 215712 109945882
Death 463.28 9.55 1287 426418 697582 109464012
Chronic kidney disease 436.64 9.55 933 426772 75358 110086236
Toxicity to various agents 427.57 9.55 752 426953 479803 109681791
Off label use 377.92 9.55 3849 423856 1496336 108665258
Product dose omission issue 332.41 9.55 455 427250 321327 109840267
Interstitial lung disease 282.66 9.55 1178 426527 138156 110023438
Therapeutic product effect incomplete 264.36 9.55 285 427420 223520 109938074
Lip swelling 255.35 9.55 589 427116 50078 110111516
Drug abuse 255.04 9.55 188 427517 177223 109984371
Swollen tongue 247.21 9.55 648 427057 59714 110101880
Subacute cutaneous lupus erythematosus 232.24 9.55 176 427529 4818 110156776
Hypomagnesaemia 227.03 9.55 628 427077 59742 110101852
Injection site pain 223.26 9.55 215 427490 177707 109983887
Cardiospasm 217.72 9.55 169 427536 4798 110156796
Acute kidney injury 207.61 9.55 3531 424174 631899 109529695
End stage renal disease 207.04 9.55 329 427376 21144 110140450
Palmoplantar keratoderma 197.30 9.55 165 427540 5222 110156372
Angioedema 196.00 9.55 828 426877 97672 110063922
Pruritus genital 191.16 9.55 176 427529 6346 110155248
Fatigue 186.82 9.55 3447 424258 1212511 108949083
Lower respiratory tract infection 186.59 9.55 1591 426114 241515 109920079
Sleep terror 179.57 9.55 171 427534 6439 110155155
Neutropenic sepsis 172.40 9.55 373 427332 30373 110131221
Cerebral infarction 165.84 9.55 509 427196 51329 110110265
Tension headache 163.64 9.55 194 427511 9424 110152170
Atrial tachycardia 159.26 9.55 187 427518 8991 110152603
Appendicolith 153.69 9.55 230 427475 14025 110147569
Pain 151.17 9.55 2692 425013 952263 109209331
Subarachnoid haemorrhage 143.87 9.55 340 427365 29362 110132232
Immunisation 141.04 9.55 109 427596 3074 110158520
Agranulocytosis 137.81 9.55 538 427167 61222 110100372
Cholestasis 135.92 9.55 552 427153 63966 110097628
Liver disorder 135.62 9.55 979 426726 141264 110020330
Confusional state 134.31 9.55 2552 425153 466128 109695466
Swelling face 132.50 9.55 706 426999 91615 110069979
Carotid artery occlusion 132.43 9.55 174 427531 9391 110152203
Drug resistance 130.57 9.55 29 427676 56345 110105249
Chest pain 129.84 9.55 2111 425594 374264 109787330
Hepatic function abnormal 128.93 9.55 684 427021 88611 110072983
Suicide attempt 128.45 9.55 126 427579 103268 110058326
Treatment failure 125.31 9.55 598 427107 276636 109884958
Intentional overdose 124.39 9.55 200 427505 132301 110029293
Appendicitis 120.05 9.55 309 427396 28155 110133439
Deep vein thrombosis postoperative 118.39 9.55 499 427206 58792 110102802
Amnesia 118.09 9.55 755 426950 104653 110056941
Lower limb fracture 115.59 9.55 587 427118 74761 110086833
Renal injury 115.36 9.55 236 427469 18477 110143117
Influenza 114.97 9.55 307 427398 168794 109992800
Rectal haemorrhage 114.36 9.55 825 426880 119008 110042586
Myelosuppression 111.49 9.55 120 427585 94220 110067374
Facial pain 111.04 9.55 207 427498 15132 110146462
Abdominal pain upper 109.77 9.55 1929 425776 347182 109814412
Accidental exposure to product 109.41 9.55 29 427676 49979 110111615
Tubulointerstitial nephritis 108.49 9.55 457 427248 53827 110107767
Anosmia 103.98 9.55 179 427526 12293 110149301
Melaena 102.23 9.55 531 427174 68226 110093368
Autoimmune disorder 101.04 9.55 511 427194 64972 110096622
Haematemesis 100.33 9.55 474 427231 58634 110102960
Injection site reaction 99.05 9.55 119 427586 88951 110072643
Blood pressure increased 98.59 9.55 590 427115 257783 109903811
Electric shock 97.56 9.55 70 427635 1758 110159836
Nephrogenic anaemia 96.10 9.55 103 427602 4474 110157120
Transient ischaemic attack 93.66 9.55 492 427213 63490 110098104
Hypergastrinaemia 92.79 9.55 39 427666 317 110161277
Liver function test abnormal 92.68 9.55 518 427187 68432 110093162
Therapeutic product effect decreased 90.03 9.55 564 427141 243752 109917842
Device expulsion 89.86 9.55 8 427697 30883 110130711
Inappropriate schedule of product administration 89.81 9.55 443 427262 203194 109958400
Overdose 87.55 9.55 537 427168 233257 109928337
Contraindicated product administered 87.47 9.55 581 427124 247686 109913908
Adjustment disorder with depressed mood 86.58 9.55 368 427337 43515 110118079
Lip dry 84.77 9.55 670 427035 99413 110062181
Disease progression 83.53 9.55 576 427129 243458 109918136
Onychomycosis 83.06 9.55 23 427682 38508 110123086
Drug dispensed to wrong patient 81.34 9.55 45 427660 704 110160890
Hypertensive nephropathy 80.12 9.55 50 427655 988 110160606
Hallucination 79.95 9.55 668 427037 100764 110060830
Muscle twitching 79.58 9.55 276 427429 29659 110131935
Hepatic cytolysis 78.98 9.55 421 427284 54632 110106962
Abdominal pain 78.72 9.55 2567 425138 510422 109651172
Ventricular fibrillation 78.09 9.55 342 427363 40971 110120623
Hypocalcaemia 77.45 9.55 475 427230 64891 110096703
Therapy partial responder 76.46 9.55 24 427681 37037 110124557
Wrong technique in product usage process 76.32 9.55 138 427567 87210 110074384
Therapy interrupted 75.26 9.55 50 427655 49772 110111822
Coeliac disease 74.28 9.55 37 427668 43150 110118444
Total lung capacity decreased 74.16 9.55 113 427592 7001 110154593
Hospitalisation 73.07 9.55 293 427412 142200 110019394
Pain of skin 72.97 9.55 206 427499 19823 110141771
Hepatocellular injury 72.46 9.55 387 427318 50255 110111339
Tinnitus 72.40 9.55 441 427264 60099 110101495
Blood cholesterol increased 70.71 9.55 1055 426650 183730 109977864
Dry mouth 70.55 9.55 1126 426579 198822 109962772
Jaundice 70.52 9.55 431 427274 58805 110102789
Injection site swelling 70.37 9.55 81 427624 61709 110099885
Blood uric acid increased 70.35 9.55 213 427492 21316 110140278
Injection site pruritus 70.22 9.55 57 427648 51201 110110393
Product use in unapproved indication 68.68 9.55 1267 426438 446110 109715484
Drug intolerance 68.24 9.55 1133 426572 405379 109756215
X-ray abnormal 67.87 9.55 310 427395 37807 110123787
Loss of personal independence in daily activities 66.93 9.55 325 427380 149695 110011899
Liver injury 66.08 9.55 880 426825 149533 110012061
Cholecystitis chronic 66.03 9.55 126 427579 9374 110152220
Lupus vulgaris 65.96 9.55 283 427422 33600 110127994
Eosinophilia 64.27 9.55 414 427291 57522 110104072
Peripheral venous disease 64.19 9.55 550 427155 83567 110078027
Pulmonary fibrosis 62.70 9.55 637 427068 101405 110060189
Therapy cessation 62.55 9.55 49 427656 44808 110116786
Exposure during pregnancy 62.43 9.55 385 427320 167039 109994555
Rhinorrhoea 62.03 9.55 197 427508 102469 110059125
Hepatotoxicity 61.10 9.55 94 427611 63306 110098288
Antimicrobial susceptibility test resistant 61.08 9.55 31 427674 403 110161191
Renal failure 60.14 9.55 1220 426485 225354 109936240
Sedation 60.07 9.55 111 427594 69572 110092022
Injection site erythema 59.54 9.55 177 427528 93999 110067595
Minimum inhibitory concentration 59.03 9.55 23 427682 150 110161444
Weight increased 57.87 9.55 1210 426495 418434 109743160
Blood lactic acid decreased 57.55 9.55 33 427672 555 110161039
Medication error 57.38 9.55 642 427063 104724 110056870
Wrong patient received product 57.23 9.55 97 427608 6577 110155017
Lung opacity 57.10 9.55 134 427571 11518 110150076
Cardiac output increased 56.37 9.55 33 427672 578 110161016
Eosinophil count decreased 56.36 9.55 91 427614 5927 110155667
Device dislocation 56.30 9.55 26 427679 31678 110129916
Sopor 56.24 9.55 285 427420 36261 110125333
Oedema 55.85 9.55 1131 426574 208845 109952749
Intervertebral discitis 55.25 9.55 98 427607 6892 110154702
Blood phosphorus increased 54.65 9.55 163 427542 16177 110145417
COVID-19 54.64 9.55 645 427060 244415 109917179
Porphyria acute 54.20 9.55 178 427527 18602 110142992
Product use issue 54.19 9.55 863 426842 310832 109850762
Hypokalaemia 54.05 9.55 999 426706 181449 109980145
Red blood cell sedimentation rate abnormal 54.02 9.55 14 427691 24495 110137099
Aplastic anaemia 53.61 9.55 211 427494 24097 110137497
Myasthenia gravis 53.47 9.55 194 427511 21317 110140277
Incorrect dose administered 53.20 9.55 213 427492 103428 110058166
Ventricular tachycardia 52.82 9.55 353 427352 49656 110111938
Poisoning deliberate 52.65 9.55 18 427687 26313 110135281
Mixed liver injury 51.84 9.55 132 427573 11947 110149647
Drug use disorder 51.72 9.55 5 427700 18069 110143525
Palpitations 51.50 9.55 884 426821 158328 110003266
Therapeutic response shortened 51.40 9.55 25 427680 29558 110132036
Haemorrhage subcutaneous 50.84 9.55 83 427622 5456 110156138
Malaise 50.81 9.55 3127 424578 668692 109492902
Venous pressure jugular increased 50.74 9.55 42 427663 1310 110160284
Post-traumatic stress disorder 50.25 9.55 91 427614 6505 110155089
Drug reaction with eosinophilia and systemic symptoms 50.20 9.55 512 427193 81583 110080011
Poisoning 49.96 9.55 25 427680 29080 110132514
Sinus congestion 49.58 9.55 28 427677 30431 110131163
Toxic epidermal necrolysis 49.27 9.55 382 427323 56345 110105249
Faeces discoloured 48.96 9.55 260 427445 33688 110127906
Product dose omission in error 48.91 9.55 15 427690 23497 110138097
Food allergy 48.82 9.55 9 427696 19939 110141655
Neoplasm progression 48.80 9.55 111 427594 64484 110097110
Nasal congestion 48.57 9.55 205 427500 98077 110063517
Haematotoxicity 48.51 9.55 11 427694 21071 110140523
Toxic skin eruption 48.41 9.55 223 427482 27292 110134302
Catarrh 48.19 9.55 95 427610 7240 110154354
Respiratory tract congestion 47.93 9.55 30 427675 30827 110130767
Road traffic accident 47.44 9.55 629 427076 106769 110054825
Adverse reaction 47.04 9.55 28 427677 29566 110132028
Gastric polyps 47.00 9.55 80 427625 5443 110156151
Diplopia 46.86 9.55 300 427405 41594 110120000
Protein-losing gastroenteropathy 46.77 9.55 34 427671 872 110160722
Urticaria 46.39 9.55 1586 426119 317271 109844323
Vitamin B1 decreased 45.68 9.55 34 427671 905 110160689
Cystitis 45.54 9.55 119 427586 65917 110095677
Dislocation of vertebra 45.21 9.55 307 427398 43414 110118180
Rash papular 44.98 9.55 219 427486 27420 110134174
Illness 44.67 9.55 165 427540 82006 110079588
Fall 44.58 9.55 1894 425811 601588 109560006
Marasmus 44.52 9.55 43 427662 1648 110159946
Foetal death 44.47 9.55 5 427700 16040 110145554
Post cholecystectomy syndrome 44.04 9.55 32 427673 820 110160774
Vasculitis 43.96 9.55 263 427442 35610 110125984
Analgesic therapy 43.88 9.55 91 427614 7193 110154401
Muscle injury 43.81 9.55 777 426928 140030 110021564
Sleep disorder therapy 43.45 9.55 92 427613 7379 110154215
Swollen joint count increased 43.41 9.55 505 427200 83156 110078438
Delirium 43.41 9.55 749 426956 134276 110027318
Cough 43.21 9.55 1408 426297 460233 109701361
Hypophosphataemia 43.08 9.55 247 427458 32935 110128659
Blood pressure systolic increased 42.95 9.55 170 427535 82821 110078773
C-reactive protein 42.86 9.55 231 427474 30100 110131494
Onychomadesis 42.77 9.55 69 427636 45594 110116000
Bronchopulmonary aspergillosis allergic 42.49 9.55 98 427607 8328 110153266
Central nervous system mass 42.38 9.55 31 427674 803 110160791
No adverse event 42.32 9.55 145 427560 73694 110087900
Device malfunction 42.32 9.55 23 427682 25535 110136059
Pancreatitis acute 42.31 9.55 387 427318 59887 110101707
Musculoskeletal pain 42.29 9.55 966 426739 182057 109979537
Upper respiratory tract inflammation 42.17 9.55 67 427638 4304 110157290
Wall motion score index abnormal 42.14 9.55 31 427674 810 110160784
Asthma 41.88 9.55 1266 426439 249025 109912569
Renal impairment 41.81 9.55 989 426716 187456 109974138
Joint range of motion decreased 41.80 9.55 683 427022 121149 110040445
Grip strength 41.44 9.55 102 427603 9039 110152555
Inappropriate antidiuretic hormone secretion 41.37 9.55 248 427457 33603 110127991
Decreased appetite 41.34 9.55 2243 425462 473603 109687991
Macular degeneration 41.29 9.55 16 427689 21643 110139951
Infusion related reaction 41.24 9.55 1140 426565 380022 109781572
Reflux gastritis 41.21 9.55 39 427666 1457 110160137
Drug dependence 41.09 9.55 82 427623 49938 110111656
Brain stem glioma 40.86 9.55 19 427686 201 110161393
Dermatitis atopic 40.83 9.55 24 427681 25517 110136077
Femoral neck fracture 40.75 9.55 124 427581 12443 110149151
Arthralgia 40.55 9.55 2536 425169 777096 109384498
Injection site bruising 40.45 9.55 86 427619 51177 110110417
Back injury 40.41 9.55 76 427629 47323 110114271
Blood alkaline phosphatase increased 40.36 9.55 436 427269 70499 110091095
Disease recurrence 40.06 9.55 112 427593 60672 110100922
Circulatory collapse 39.86 9.55 294 427411 42699 110118895
Diabetic nephropathy 39.83 9.55 58 427647 3450 110158144
Product label confusion 39.65 9.55 19 427686 22658 110138936
Drug ineffective for unapproved indication 39.63 9.55 234 427471 102604 110058990
Diarrhoea 39.53 9.55 5007 422698 1134498 109027096
Device difficult to use 39.11 9.55 12 427693 18793 110142801
Sciatica 39.10 9.55 537 427168 91862 110069732
Multiple sclerosis relapse 39.04 9.55 85 427620 50155 110111439
Bursitis 39.04 9.55 713 426992 129205 110032389
Labile blood pressure 39.03 9.55 48 427657 2423 110159171
Airway remodelling 39.02 9.55 31 427674 911 110160683
Blood pressure fluctuation 38.90 9.55 153 427552 74671 110086923
Full blood count decreased 38.85 9.55 40 427665 32059 110129535
Gastritis 38.83 9.55 347 427358 53352 110108242
Hypoparathyroidism secondary 38.81 9.55 20 427685 269 110161325
Rheumatoid nodule 38.68 9.55 15 427690 20281 110141313
Electrocardiogram QT prolonged 38.56 9.55 614 427091 108346 110053248
Sinus disorder 38.25 9.55 42 427663 32686 110128908
Infective pulmonary exacerbation of cystic fibrosis 38.23 9.55 135 427570 14636 110146958
Temperature regulation disorder 38.19 9.55 3 427702 12823 110148771
Purpura 38.10 9.55 191 427514 24197 110137397
Burns second degree 37.97 9.55 89 427616 7644 110153950
Vomiting 37.64 9.55 4047 423658 906628 109254966
Dehydration 37.61 9.55 1378 426327 278133 109883461
Lung disorder 37.26 9.55 936 426769 179111 109982483
Pathogen resistance 37.26 9.55 11 427694 17661 110143933
Device dependence 37.24 9.55 13 427692 59 110161535
Pemphigoid 37.13 9.55 163 427542 19544 110142050
Disseminated intravascular coagulation 36.95 9.55 280 427425 41006 110120588
Activated partial thromboplastin time prolonged 36.95 9.55 178 427527 22190 110139404
Enthesopathy 36.93 9.55 3 427702 12475 110149119
Urine magnesium decreased 36.47 9.55 8 427697 0 110161594
Demyelination 36.35 9.55 99 427606 9330 110152264
Parosmia 36.33 9.55 123 427582 13057 110148537
Immunodeficiency 36.08 9.55 59 427646 38779 110122815
Chills 36.07 9.55 519 427186 190061 109971533
Hypoacusis 36.04 9.55 50 427655 35141 110126453
Hyperphosphataemia 35.97 9.55 142 427563 16239 110145355
Procedural pain 35.96 9.55 51 427654 35514 110126080
Finger deformity 35.96 9.55 45 427660 33047 110128547
Hyperkalaemia 35.95 9.55 731 426974 135065 110026529
Bone pain 35.92 9.55 130 427575 65003 110096591
Cardiac septal defect 35.83 9.55 30 427675 951 110160643
Mental status changes 35.65 9.55 162 427543 75960 110085634
Drug effective for unapproved indication 35.52 9.55 6 427699 14161 110147433
White blood cell count increased 35.51 9.55 549 427156 96293 110065301
Pleuritic pain 35.51 9.55 140 427565 16000 110145594
Coma 35.18 9.55 289 427416 117580 110044014
Pneumonia bacterial 35.09 9.55 197 427508 26064 110135530
Gastrointestinal polyp haemorrhage 35.04 9.55 27 427678 758 110160836
Biliary dyskinesia 35.01 9.55 45 427660 2376 110159218
Erythema multiforme 34.94 9.55 168 427537 20929 110140665
Proctitis 34.85 9.55 11 427694 16916 110144678
Intentional dose omission 34.84 9.55 17 427688 20063 110141531
Nephropathy 34.79 9.55 123 427582 13344 110148250
Skin haemorrhage 34.77 9.55 27 427678 24800 110136794
Enterochromaffin cell hyperplasia 34.70 9.55 13 427692 75 110161519
Tetanus 34.28 9.55 12 427693 55 110161539
Oesophagitis 34.22 9.55 209 427496 28506 110133088
Pneumonia aspiration 33.92 9.55 471 427234 80762 110080832
Pain in extremity 33.64 9.55 1540 426165 485578 109676016
Atopy 33.55 9.55 31 427674 1123 110160471
Limb discomfort 33.53 9.55 67 427638 40787 110120807
Joint swelling 33.48 9.55 1386 426319 441459 109720135
Psoriasis 33.33 9.55 363 427342 139630 110021964
Occupational dermatitis 33.17 9.55 15 427690 148 110161446
Chronic kidney disease-mineral and bone disorder 33.07 9.55 24 427681 614 110160980
Bronchiectasis 32.95 9.55 248 427457 36245 110125349
Transplant rejection 32.81 9.55 28 427677 24539 110137055
Nightmare 32.80 9.55 260 427445 38603 110122991
Steroid dependence 32.72 9.55 89 427616 8380 110153214
Device issue 32.52 9.55 52 427653 34483 110127111
Basal cell carcinoma 32.43 9.55 80 427625 45190 110116404
Neutrophil count decreased 32.33 9.55 652 427053 120289 110041305
Cerebral haemorrhage 32.31 9.55 389 427316 64579 110097015
Obesity 32.30 9.55 617 427088 112734 110048860
Sinusitis 32.17 9.55 887 426818 295801 109865793
Coronary artery disease 32.13 9.55 421 427284 71269 110090325
Hip fracture 32.10 9.55 54 427651 35097 110126497
Neuroendocrine tumour 32.07 9.55 35 427670 1552 110160042
Type 2 diabetes mellitus 31.97 9.55 905 426800 176327 109985267
Gingival pain 31.84 9.55 133 427572 15603 110145991
Vitamin B1 increased 31.75 9.55 15 427690 165 110161429
Oedema peripheral 31.73 9.55 1565 426140 327095 109834499
Drug therapy 31.62 9.55 80 427625 7211 110154383
Muscle spasticity 31.14 9.55 57 427648 35858 110125736
Personality disorder 30.97 9.55 6 427699 12831 110148763
Haemoptysis 30.72 9.55 416 427289 70938 110090656
Nasopharyngitis 30.50 9.55 1231 426474 393130 109768464
Heart rate decreased 30.48 9.55 191 427514 82565 110079029
International normalised ratio increased 30.34 9.55 488 427217 86284 110075310
Female genital tract fistula 30.19 9.55 13 427692 16506 110145088
Aspiration 30.15 9.55 212 427493 30321 110131273
Enteritis infectious 30.14 9.55 54 427651 3828 110157766
Wheezing 30.01 9.55 1240 426465 253990 109907604
Migraine 29.99 9.55 873 426832 170779 109990815
Exposure via skin contact 29.97 9.55 7 427698 13140 110148454
Synovitis 29.83 9.55 819 426886 273273 109888321
Cardiac murmur 29.82 9.55 180 427525 24448 110137146
Pneumonia 29.78 9.55 2953 424752 873761 109287833
Irritable bowel syndrome 29.75 9.55 839 426866 163376 109998218
Hypotension 29.68 9.55 1690 426015 522159 109639435
Hepatic ischaemia 29.58 9.55 30 427675 1221 110160373
Tachypnoea 29.51 9.55 68 427637 39327 110122267
Hypopnoea 29.45 9.55 104 427601 11276 110150318
Epstein-Barr virus infection 29.40 9.55 18 427687 18720 110142874
Cholecystitis acute 29.33 9.55 130 427575 15652 110145942
Immune reconstitution inflammatory syndrome 29.29 9.55 13 427692 16213 110145381
Subdural haematoma 29.21 9.55 241 427464 36213 110125381
Post transplant lymphoproliferative disorder 29.00 9.55 12 427693 15601 110145993
Blood immunoglobulin A increased 28.97 9.55 33 427672 1535 110160059
Panniculitis 28.90 9.55 12 427693 15570 110146024
Coma scale abnormal 28.80 9.55 93 427612 9633 110151961
Genital pain 28.51 9.55 31 427674 1369 110160225
Blindness 28.40 9.55 239 427466 36120 110125474
Somatic delusion 28.32 9.55 23 427682 698 110160896
Cardiotoxicity 28.23 9.55 15 427690 16866 110144728
Hepatitis acute 27.94 9.55 145 427560 18621 110142973
Carcinoid tumour of the stomach 27.86 9.55 14 427691 178 110161416
Hyperchlorhydria 27.80 9.55 38 427667 2131 110159463
Wound infection 27.79 9.55 526 427179 95939 110065655
Incorrect route of product administration 27.79 9.55 374 427331 63687 110097907
Cholangitis 27.72 9.55 131 427574 16204 110145390
Musculoskeletal disorder 27.70 9.55 28 427677 22636 110138958
Neurotoxicity 27.64 9.55 78 427627 42129 110119465
Polyneuropathy 27.58 9.55 51 427654 31961 110129633
Red cell distribution width increased 27.49 9.55 17 427688 17585 110144009
Blood calcium increased 27.28 9.55 140 427565 17900 110143694
Surgery 27.25 9.55 76 427629 41207 110120387
Lethargy 27.22 9.55 511 427194 93065 110068529
Lupus-like syndrome 27.17 9.55 259 427446 40533 110121061
Prescribed overdose 27.13 9.55 483 427222 87098 110074496
Radiculopathy 27.11 9.55 21 427684 19315 110142279
Immune thrombocytopenia 26.98 9.55 164 427541 22330 110139264
Therapeutic response delayed 26.96 9.55 30 427675 1360 110160234
Sensory loss 26.81 9.55 26 427679 21431 110140163
Injury 26.59 9.55 885 426820 176380 109985214
Cardio-respiratory arrest 26.53 9.55 303 427402 115533 110046061
Biliary sepsis 26.25 9.55 34 427671 1809 110159785
Unevaluable event 26.00 9.55 129 427576 59098 110102496
Blood sodium decreased 25.87 9.55 244 427461 38075 110123519
Electrocardiogram QRS complex prolonged 25.86 9.55 9 427696 13012 110148582
Breast cancer stage III 25.83 9.55 440 427265 78677 110082917
Acne 25.81 9.55 57 427648 33463 110128131
Drug dose omission by device 25.63 9.55 12 427693 14504 110147090
Night sweats 25.52 9.55 689 427016 133294 110028300
Gastric dysplasia 25.48 9.55 8 427697 24 110161570
Cardiac arrest 25.44 9.55 573 427132 196180 109965414
Ascites 25.36 9.55 502 427203 92306 110069288
Tetany 25.29 9.55 48 427657 3556 110158038
Lymphadenopathy 25.27 9.55 144 427561 63691 110097903
Hyperlactacidaemia 25.24 9.55 80 427625 8206 110153388
Hypervolaemia 25.16 9.55 102 427603 49358 110112236
Cataract 25.05 9.55 192 427513 79293 110082301
Idiopathic pulmonary fibrosis 25.02 9.55 58 427647 4946 110156648
Urine potassium decreased 24.97 9.55 7 427698 12 110161582
Terminal insomnia 24.91 9.55 34 427671 1904 110159690
Drug hypersensitivity 24.80 9.55 1470 426235 452620 109708974
Gastrointestinal motility disorder 24.73 9.55 73 427632 7203 110154391
Walking aid user 24.70 9.55 174 427531 24901 110136693
Gastric cancer 24.64 9.55 96 427609 10912 110150682
Hyperlipidaemia 24.57 9.55 229 427476 35619 110125975
Facet joint syndrome 24.56 9.55 518 427187 96310 110065284
Aspartate aminotransferase 24.32 9.55 24 427681 945 110160649
Skin candida 24.30 9.55 37 427668 2291 110159303
Abnormal loss of weight 24.23 9.55 91 427614 10166 110151428
Administration site inflammation 24.14 9.55 10 427695 78 110161516
Adjustment disorder 24.11 9.55 6 427699 10789 110150805
Swollen joint count 23.95 9.55 81 427624 8593 110153001
Enterocolitis 23.91 9.55 140 427565 18809 110142785
Respiratory arrest 23.90 9.55 130 427575 58169 110103425
Complication of device insertion 23.88 9.55 3 427702 8835 110152759
Restlessness 23.87 9.55 124 427581 56135 110105459
Muscle spasms 23.69 9.55 1309 426396 276848 109884746
Skin necrosis 23.64 9.55 29 427676 21483 110140111
Upper gastrointestinal haemorrhage 23.63 9.55 297 427408 49799 110111795
Hepatitis cholestatic 23.62 9.55 132 427573 17434 110144160
Cytokine release syndrome 23.51 9.55 167 427538 70139 110091455
Multiple allergies 23.47 9.55 9 427696 12254 110149340
Gastrointestinal toxicity 23.39 9.55 7 427698 11141 110150453
Occupational exposure to air contaminants 23.38 9.55 12 427693 160 110161434
C-reactive protein abnormal 23.31 9.55 662 427043 129033 110032561
Human T-cell lymphotropic virus infection 23.22 9.55 6 427699 6 110161588
Uveitis 23.09 9.55 30 427675 21680 110139914
Device leakage 23.05 9.55 17 427688 16031 110145563
Barrett's oesophagus 23.00 9.55 20 427685 668 110160926
Orthostatic hypotension 22.94 9.55 372 427333 65877 110095717
Rectal ulcer 22.93 9.55 38 427667 2529 110159065
Hypoglobulinaemia 22.81 9.55 13 427692 216 110161378
Eye pruritus 22.78 9.55 210 427495 32565 110129029
Fluid retention 22.66 9.55 244 427461 94063 110067531
Post viral fatigue syndrome 22.64 9.55 14 427691 272 110161322
Skin oedema 22.62 9.55 33 427672 1966 110159628
Mouth ulceration 22.54 9.55 285 427420 47853 110113741
Eye irritation 22.52 9.55 61 427644 33391 110128203
Hospice care 22.51 9.55 10 427695 12463 110149131
Gastric varices 22.48 9.55 22 427683 857 110160737
Therapeutic response decreased 22.26 9.55 252 427453 96247 110065347
Maternal exposure during pregnancy 22.04 9.55 785 426920 254098 109907496
Basilar artery occlusion 22.03 9.55 14 427691 286 110161308
Hyperparathyroidism secondary 21.96 9.55 43 427662 3261 110158333
Retinitis 21.90 9.55 206 427499 32121 110129473
Glomerular filtration rate increased 21.86 9.55 32 427673 1913 110159681
Nail ridging 21.78 9.55 18 427687 560 110161034
Pancreatitis 21.70 9.55 494 427211 93039 110068555
Central nervous system lesion 21.67 9.55 17 427688 15536 110146058
Hypophosphataemic osteomalacia 21.66 9.55 16 427689 421 110161173
Eosinophilic myocarditis 21.57 9.55 33 427672 2052 110159542
Mouth swelling 21.49 9.55 70 427635 7284 110154310
Abortion spontaneous 21.26 9.55 65 427640 34217 110127377
Rheumatoid factor positive 21.24 9.55 663 427042 130977 110030617
Poor venous access 21.19 9.55 39 427666 24483 110137111
Neuropathy, ataxia, retinitis pigmentosa syndrome 21.09 9.55 8 427697 48 110161546
Substance abuse 20.95 9.55 11 427694 12452 110149142
Osteoarthritis 20.95 9.55 885 426820 181738 109979856
Rheumatoid factor increased 20.94 9.55 36 427669 2469 110159125
Renal cyst 20.86 9.55 131 427574 18041 110143553
Platelet count decreased 20.72 9.55 1090 426615 229353 109932241
Nephrocalcinosis 20.61 9.55 30 427675 1784 110159810
Rebound acid hypersecretion 20.55 9.55 10 427695 118 110161476
Muscle relaxant therapy 20.53 9.55 11 427694 161 110161433
Cardioactive drug level increased 20.52 9.55 46 427659 3836 110157758
Secretion discharge 20.50 9.55 29 427676 20215 110141379
Gastric ulcer 20.48 9.55 240 427465 39587 110122007
Rash maculo-papular 20.46 9.55 402 427303 73820 110087774
Skin toxicity 20.41 9.55 10 427695 11773 110149821
Device use error 20.40 9.55 5 427700 9084 110152510
Iron deficiency anaemia 20.34 9.55 199 427506 31360 110130234
Erythema dyschromicum perstans 20.25 9.55 9 427696 85 110161509
Hypoglycaemic coma 20.24 9.55 57 427648 5476 110156118
Flushing 20.24 9.55 284 427421 104452 110057142
Condition aggravated 20.20 9.55 2511 425194 732325 109429269
Genital ulceration 20.06 9.55 31 427674 1944 110159650
Granulocyte count increased 19.97 9.55 31 427674 1952 110159642
Blood pressure abnormal 19.97 9.55 35 427670 22389 110139205
Insurance issue 19.96 9.55 8 427697 10604 110150990
Akathisia 19.96 9.55 22 427683 17091 110144503
Unintentional medical device removal 19.85 9.55 5 427700 8918 110152676
Fear of injection 19.81 9.55 5 427700 8906 110152688
Acute coronary syndrome 19.71 9.55 155 427550 22957 110138637
Colitis ulcerative 19.66 9.55 414 427291 76949 110084645
Maternal exposure timing unspecified 19.65 9.55 144 427561 20869 110140725
Rash vesicular 19.63 9.55 110 427595 14542 110147052
Achlorhydria 19.62 9.55 6 427699 16 110161578
Myocardial ischaemia 19.58 9.55 173 427532 26511 110135083
Sneezing 19.58 9.55 61 427644 31923 110129671
Nausea 19.51 9.55 4356 423349 1231334 108930260
Pulmonary thrombosis 19.51 9.55 15 427690 13848 110147746
Gastrointestinal tract irritation 19.50 9.55 20 427685 825 110160769
Leukocytosis 19.43 9.55 125 427580 53703 110107891
Carbuncle 19.25 9.55 26 427679 1441 110160153
Prostate tenderness 19.25 9.55 8 427697 63 110161531
Product preparation error 19.20 9.55 9 427696 10870 110150724
Acute respiratory failure 19.20 9.55 192 427513 75068 110086526
Vitamin B12 increased 19.14 9.55 31 427674 2024 110159570
Cardiac failure 19.05 9.55 898 426807 186728 109974866
Blood iron decreased 18.98 9.55 28 427677 19186 110142408
Herpes zoster 18.84 9.55 300 427405 108079 110053515
Pericarditis 18.82 9.55 1032 426673 218082 109943512
Anticoagulation drug level abnormal 18.81 9.55 13 427692 307 110161287
Face oedema 18.70 9.55 205 427500 33264 110128330
Thrombotic cerebral infarction 18.70 9.55 19 427686 775 110160819
Cystitis escherichia 18.70 9.55 19 427686 775 110160819
Hyperglycaemia 18.69 9.55 446 427259 84644 110076950
Renal atrophy 18.68 9.55 33 427672 2313 110159281
BK virus infection 18.68 9.55 14 427691 13092 110148502
Iron deficiency 18.66 9.55 129 427576 18347 110143247
Hyponatraemic syndrome 18.64 9.55 19 427686 778 110160816
Blood parathyroid hormone decreased 18.63 9.55 14 427691 13075 110148519
Carotid artery thrombosis 18.57 9.55 7 427698 9631 110151963
Respiratory tract infection 18.56 9.55 182 427523 71435 110090159
Dilatation atrial 18.55 9.55 44 427661 3808 110157786
Mucormycosis 18.44 9.55 9 427696 10619 110150975
Increased viscosity of upper respiratory secretion 18.42 9.55 17 427688 615 110160979
Haemodynamic instability 18.39 9.55 38 427667 22850 110138744
Motor dysfunction 18.38 9.55 42 427663 24364 110137230
Premature delivery 18.34 9.55 59 427646 30573 110131021
Anal prolapse 18.33 9.55 8 427697 72 110161522
Adrenal insufficiency 18.19 9.55 247 427458 42143 110119451
Disturbance in attention 18.19 9.55 339 427366 61656 110099938
Injection site urticaria 18.09 9.55 24 427681 17191 110144403
Product monitoring error 18.03 9.55 6 427699 8921 110152673
Psychotic disorder 18.02 9.55 119 427586 50818 110110776
Chronic graft versus host disease 18.00 9.55 7 427698 9450 110152144
Therapeutic response unexpected 17.98 9.55 41 427664 23802 110137792
Urine output decreased 17.90 9.55 135 427570 19741 110141853
Injection site rash 17.89 9.55 40 427665 23379 110138215
Heart rate irregular 17.86 9.55 70 427635 34204 110127390
Alcoholic liver disease 17.85 9.55 16 427689 557 110161037
Urinary tract infection 17.84 9.55 1056 426649 325226 109836368
Septic shock 17.83 9.55 468 427237 157060 110004534
Eosinophilic pneumonia 17.81 9.55 65 427640 7162 110154432
Rash morbilliform 17.52 9.55 69 427636 7882 110153712
Injection site haemorrhage 17.51 9.55 67 427638 32961 110128633
Neoplasm malignant 17.42 9.55 79 427626 37064 110124530
Joint effusion 17.40 9.55 34 427671 20871 110140723
Extravasation blood 17.33 9.55 15 427690 498 110161096
Hiatus hernia 17.27 9.55 173 427532 27433 110134161
Drug level below therapeutic 17.25 9.55 12 427693 11661 110149933
Sarcoidosis 17.21 9.55 14 427691 12565 110149029
Ocular myasthenia 17.21 9.55 18 427687 760 110160834
Ulcer 17.20 9.55 248 427457 42868 110118726
Aspergillus infection 17.03 9.55 47 427658 25569 110136025
Vasculitic rash 17.02 9.55 31 427674 2226 110159368
Nasal oedema 16.92 9.55 3 427702 6836 110154758
Breast cancer female 16.91 9.55 14 427691 12454 110149140
Altered state of consciousness 16.87 9.55 315 427390 57311 110104283
Radiation pneumonitis 16.86 9.55 47 427658 4489 110157105
Breast cancer stage II 16.86 9.55 171 427534 27204 110134390
Vaginal discharge 16.83 9.55 27 427678 17881 110143713
Drug eruption 16.65 9.55 296 427409 53363 110108231
Metabolic disorder 16.63 9.55 10 427695 10500 110151094
Upper limb fracture 16.51 9.55 35 427670 20853 110140741
Joint injury 16.49 9.55 89 427616 39905 110121689
Pituitary tumour benign 16.49 9.55 35 427670 2812 110158782
Blood test abnormal 16.47 9.55 176 427529 28378 110133216
Blood gastrin increased 16.44 9.55 7 427698 59 110161535
SARS-CoV-2 test positive 16.42 9.55 25 427680 16910 110144684
Metastases to bone 16.40 9.55 64 427641 31308 110130286
Oesophageal achalasia 16.40 9.55 20 427685 1001 110160593
Hepatic enzyme increased 16.25 9.55 1046 426659 319846 109841748
Enterocolitis haemorrhagic 16.24 9.55 33 427672 2571 110159023
Ventricular hypertrophy 16.23 9.55 62 427643 6983 110154611
Oesophageal mucosal tear 16.17 9.55 5 427700 14 110161580
Aortic stenosis 16.17 9.55 96 427609 12963 110148631
Pelvic cyst 16.14 9.55 7 427698 62 110161532
Transplant dysfunction 16.13 9.55 6 427699 8322 110153272
Skin burning sensation 16.08 9.55 38 427667 21787 110139807
Pancreatic carcinoma recurrent 16.05 9.55 10 427695 197 110161397
Localised infection 16.03 9.55 99 427606 42949 110118645
Picornavirus infection 15.98 9.55 9 427696 146 110161448
Blood pressure diastolic abnormal 15.97 9.55 49 427656 25766 110135828
Influenza like illness 15.95 9.55 243 427462 88169 110073425
Rhinitis 15.95 9.55 145 427560 22400 110139194
Haemorrhagic cerebral infarction 15.94 9.55 24 427681 1471 110160123
Acute graft versus host disease in skin 15.92 9.55 11 427694 10729 110150865
Penile curvature 15.92 9.55 5 427700 15 110161579
Vitamin B12 deficiency 15.88 9.55 79 427626 9976 110151618
Underdose 15.85 9.55 163 427542 63391 110098203
Stoma site haemorrhage 15.68 9.55 31 427674 2367 110159227
Middle insomnia 15.67 9.55 35 427670 20467 110141127
Duodenal ulcer perforation 15.67 9.55 839 426866 176861 109984733
Weight decreased 15.64 9.55 1578 426127 466479 109695115
Acute myeloid leukaemia 15.61 9.55 85 427620 38025 110123569
Plasma cell myeloma recurrent 15.56 9.55 4 427701 7038 110154556
Hiccups 15.54 9.55 94 427611 12775 110148819
Cerebral mass effect 15.50 9.55 31 427674 2388 110159206
Embolic stroke 15.48 9.55 71 427634 8672 110152922
Immobilisation syndrome 15.45 9.55 18 427687 858 110160736
Malignant melanoma 15.37 9.55 26 427679 16865 110144729
Photodermatosis 15.34 9.55 20 427685 1071 110160523
Oxygen saturation decreased 15.33 9.55 476 427229 156506 110005088
Neurological symptom 15.17 9.55 23 427682 15585 110146009
Muscle tension dysphonia 15.17 9.55 11 427694 281 110161313
Syringe issue 15.16 9.55 9 427696 9516 110152078
Multiple drug therapy 15.14 9.55 6 427699 8008 110153586
Pulmonary oedema 15.12 9.55 286 427419 100373 110061221
Bradycardia 15.09 9.55 741 426964 154776 110006818
Alcohol poisoning 15.06 9.55 72 427633 8948 110152646
Neuroleptic malignant syndrome 15.06 9.55 74 427631 33985 110127609
Respiratory depression 15.05 9.55 68 427637 31933 110129661
Bile duct stone 15.03 9.55 56 427649 6233 110155361
Anaemia vitamin B12 deficiency 14.98 9.55 21 427684 1206 110160388
Graft versus host disease in gastrointestinal tract 14.95 9.55 8 427697 8960 110152634
Macroglossia 14.94 9.55 23 427682 1438 110160156
Dysphagia 14.93 9.55 732 426973 152868 110008726
Bronchitis 14.89 9.55 478 427227 156554 110005040
Cutaneous lupus erythematosus 14.85 9.55 38 427667 3450 110158144
Hypozincaemia 14.82 9.55 7 427698 77 110161517
Urine phosphorus decreased 14.80 9.55 6 427699 44 110161550
Endocarditis enterococcal 14.75 9.55 12 427693 365 110161229
Hepatic cirrhosis 14.71 9.55 354 427351 67272 110094322
Prostatic specific antigen increased 14.68 9.55 16 427689 12495 110149099
Failure to anastomose 14.62 9.55 10 427695 232 110161362
Body temperature increased 14.62 9.55 138 427567 54575 110107019
Osteonecrosis of jaw 14.58 9.55 264 427441 47753 110113841
Enterococcal infection 14.58 9.55 36 427669 20330 110141264
Osteopenia 14.58 9.55 41 427664 22168 110139426
Hepatorenal syndrome 14.57 9.55 45 427660 4552 110157042
Burn oral cavity 14.55 9.55 9 427696 175 110161419
Acute graft versus host disease 14.54 9.55 17 427688 12864 110148730
Oropharyngeal oedema 14.51 9.55 13 427692 452 110161142
Laryngotracheal oedema 14.47 9.55 6 427699 47 110161547
Follicular mucinosis 14.45 9.55 5 427700 22 110161572
Embolic cerebral infarction 14.41 9.55 23 427682 1483 110160111
Hyperuricaemia 14.41 9.55 101 427604 14430 110147164
Melanoderma 14.39 9.55 13 427692 457 110161137
Rhabdomyolysis 14.38 9.55 586 427119 119815 110041779
Cardiogenic shock 14.30 9.55 306 427399 57032 110104562
Sedation complication 14.29 9.55 35 427670 19820 110141774
Cytomegalovirus infection reactivation 14.26 9.55 31 427674 18302 110143292
Body temperature decreased 14.25 9.55 84 427621 36851 110124743
Cerebellar infarction 14.22 9.55 42 427663 4145 110157449
Cholecystitis 14.22 9.55 158 427547 25724 110135870
Visual impairment 14.21 9.55 646 427059 133782 110027812
Subcutaneous drug absorption impaired 14.17 9.55 63 427642 7596 110153998
Mesenteric artery embolism 14.14 9.55 7 427698 86 110161508
Laryngeal pain 14.11 9.55 53 427652 5922 110155672
Blood pressure systolic abnormal 14.10 9.55 49 427656 24801 110136793
Folliculitis 14.08 9.55 788 426917 166865 109994729
Fungal infection 14.07 9.55 127 427578 50679 110110915
Myositis 14.05 9.55 183 427522 30933 110130661
Arterial intramural haematoma 14.05 9.55 10 427695 248 110161346
Syncope 14.03 9.55 936 426769 201600 109959994
Bleeding time prolonged 14.02 9.55 21 427684 1281 110160313
Palatal ulcer 14.01 9.55 10 427695 249 110161345
Intentional self-injury 13.98 9.55 86 427619 37343 110124251
Blood creatine phosphokinase increased 13.97 9.55 376 427329 72701 110088893
Essential thrombocythaemia 13.92 9.55 12 427693 396 110161198
Vitamin D decreased 13.92 9.55 16 427689 12199 110149395
Haematuria 13.91 9.55 420 427285 82585 110079009
Upper-airway cough syndrome 13.90 9.55 25 427680 15832 110145762
Skin wrinkling 13.89 9.55 23 427682 1530 110160064
Anticoagulant therapy 13.88 9.55 49 427656 5312 110156282
Chronic sinusitis 13.87 9.55 50 427655 25034 110136560
Colon cancer 13.87 9.55 110 427595 16333 110145261
Tuberculosis 13.87 9.55 30 427675 17744 110143850
Chromaturia 13.82 9.55 174 427531 29186 110132408
Dermatitis exfoliative 13.78 9.55 83 427622 11264 110150330
Nephropathy toxic 13.77 9.55 57 427648 27421 110134173
Sluggishness 13.76 9.55 6 427699 7561 110154033
Faecal vomiting 13.75 9.55 23 427682 1543 110160051
Dyspnoea exertional 13.75 9.55 302 427403 103758 110057836
Renal hypertension 13.74 9.55 10 427695 257 110161337
Scratch 13.74 9.55 18 427687 12961 110148633
Spleen congestion 13.73 9.55 13 427692 486 110161108
Infusion site streaking 13.68 9.55 14 427691 576 110161018
Peritoneal mesothelioma malignant 13.68 9.55 3 427702 0 110161594
Oesophageal anastomosis 13.68 9.55 3 427702 0 110161594
Glycated albumin increased 13.68 9.55 3 427702 0 110161594
Lip oedema 13.67 9.55 62 427643 7538 110154056
Posterior reversible encephalopathy syndrome 13.61 9.55 76 427629 33785 110127809
Hypovitaminosis 13.57 9.55 22 427683 1438 110160156
Aortic dissection 13.56 9.55 46 427659 4887 110156707
Blister 13.55 9.55 1038 426667 226338 109935256
Heat illness 13.51 9.55 16 427689 776 110160818
Renal function test abnormal 13.48 9.55 9 427696 8937 110152657
Metastases to lung 13.41 9.55 45 427660 23018 110138576
Lacunar infarction 13.41 9.55 54 427651 6232 110155362
Drug specific antibody present 13.38 9.55 8 427697 8426 110153168
Adverse drug reaction 13.36 9.55 517 427188 105042 110056552
Paradoxical drug reaction 13.34 9.55 11 427694 9806 110151788
Ankylosing spondylitis 13.34 9.55 25 427680 15587 110146007
Neutrophil count increased 13.30 9.55 198 427507 34454 110127140
Contraindication to medical treatment 13.30 9.55 21 427684 1342 110160252
Gastrointestinal infection 13.27 9.55 21 427684 13984 110147610
Seasonal allergy 13.25 9.55 36 427669 19686 110141908
Encephalopathy 13.22 9.55 227 427478 80828 110080766
Pregnancy 13.21 9.55 274 427431 50793 110110801
Respiratory syncytial virus test positive 13.19 9.55 22 427683 1472 110160122
Vulvovaginal candidiasis 13.17 9.55 35 427670 3250 110158344
Hypophagia 13.17 9.55 281 427424 52345 110109249
Neurologic neglect syndrome 13.16 9.55 10 427695 9288 110152306
Progressive multifocal leukoencephalopathy 13.10 9.55 151 427554 24805 110136789
Skin cancer 13.08 9.55 31 427674 17753 110143841
Intracranial haematoma 13.08 9.55 18 427687 1016 110160578
Oculomucocutaneous syndrome 13.08 9.55 11 427694 351 110161243
Creatinine renal clearance decreased 13.08 9.55 42 427663 21773 110139821
Product prescribing error 13.07 9.55 131 427574 51200 110110394
Blood albumin decreased 13.07 9.55 164 427541 27488 110134106
Nephrosclerosis 13.07 9.55 26 427679 1995 110159599
Pseudocellulitis 13.03 9.55 12 427693 433 110161161
Mitral valve replacement 12.99 9.55 14 427691 612 110160982
Coordination abnormal 12.96 9.55 152 427553 25076 110136518
Dyslalia 12.91 9.55 21 427684 1376 110160218
Vision blurred 12.89 9.55 390 427315 128632 110032962
Respiratory failure 12.85 9.55 691 427014 214641 109946953
Clostridium test positive 12.80 9.55 79 427626 10814 110150780
Gallbladder injury 12.78 9.55 20 427685 1268 110160326
Polyomavirus-associated nephropathy 12.70 9.55 8 427697 8193 110153401
Adenoidectomy 12.69 9.55 8 427697 161 110161433
Oral mucosal discolouration 12.69 9.55 11 427694 366 110161228
Anaemia 12.67 9.55 2351 425354 544735 109616859
Product administration interrupted 12.64 9.55 15 427690 11277 110150317
Drug interaction 12.61 9.55 2159 425546 498024 109663570
Endoscopic retrograde cholangiopancreatography 12.58 9.55 9 427696 225 110161369
Hypocalciuria 12.53 9.55 5 427700 35 110161559
Joint noise 12.46 9.55 46 427659 5097 110156497
Erectile dysfunction 12.45 9.55 118 427587 18438 110143156
Staphylococcus test positive 12.43 9.55 59 427646 7311 110154283
Brain stem haemorrhage 12.42 9.55 24 427681 1802 110159792
Single functional kidney 12.41 9.55 10 427695 300 110161294
Upper respiratory tract infection 12.39 9.55 400 427305 130928 110030666
Thalamus haemorrhage 12.38 9.55 25 427680 1939 110159655
Cerebral ventricular rupture 12.36 9.55 12 427693 463 110161131
Sleep disorder due to general medical condition, insomnia type 12.35 9.55 513 427192 105130 110056464
Dysphemia 12.32 9.55 39 427666 3998 110157596
Human herpesvirus 6 infection 12.32 9.55 5 427700 6576 110155018
Pharyngeal oedema 12.31 9.55 107 427598 16321 110145273
Ocular discomfort 12.31 9.55 9 427696 8524 110153070
Microangiopathy 12.26 9.55 32 427673 2940 110158654
Fibromyalgia 12.22 9.55 792 426913 170117 109991477
Pharyngotonsillitis 12.21 9.55 10 427695 307 110161287
Feeling jittery 12.21 9.55 24 427681 14698 110146896
Diffuse vasculitis 12.19 9.55 7 427698 118 110161476
Microcytic anaemia 12.15 9.55 52 427653 6166 110155428
C-reactive protein increased 12.14 9.55 704 427001 217215 109944379
Tongue disorder 12.12 9.55 23 427682 14275 110147319
Contusion 12.08 9.55 1054 426651 232307 109929287
Gait disturbance 12.08 9.55 919 426786 277289 109884305
Anal spasm 12.03 9.55 8 427697 177 110161417
Dermatitis bullous 12.02 9.55 112 427593 17417 110144177
Hypocholesterolaemia 12.01 9.55 53 427652 6368 110155226
Neutrophil count 11.98 9.55 11 427694 395 110161199
Discoloured vomit 11.92 9.55 25 427680 1992 110159602
Deformity 11.92 9.55 13 427692 10147 110151447
Cardiac septal hypertrophy 11.91 9.55 11 427694 398 110161196
Adenovirus infection 11.89 9.55 15 427690 10979 110150615
Cognitive disorder 11.89 9.55 432 427273 87079 110074515
Memory impairment 11.88 9.55 900 426805 196044 109965550
Spinal operation 11.84 9.55 15 427690 10957 110150637
Myocardial infarction 11.79 9.55 879 426826 191204 109970390
N-telopeptide urine increased 11.75 9.55 5 427700 42 110161552
Skin exfoliation 11.69 9.55 254 427451 87397 110074197
Needle issue 11.66 9.55 33 427672 17807 110143787
Cushingoid 11.64 9.55 17 427688 11695 110149899
Cytomegalovirus test positive 11.63 9.55 56 427649 6980 110154614
Pyelonephritis acute 11.63 9.55 57 427648 7156 110154438
Ovarian fibroma 11.62 9.55 6 427699 81 110161513
Anti A antibody 11.61 9.55 3 427702 3 110161591
Temperature intolerance 11.59 9.55 93 427612 13857 110147737
Hemiplegia 11.58 9.55 47 427658 22735 110138859
Productive cough 11.55 9.55 345 427360 113960 110047634
Hepatic enzyme 11.53 9.55 45 427660 5118 110156476
Glossitis 11.53 9.55 41 427664 4460 110157134
Foot operation 11.51 9.55 7 427698 7306 110154288
Incorrect dose administered by device 11.48 9.55 6 427699 6808 110154786
Rheumatic fever 11.46 9.55 582 427123 121997 110039597
Blood magnesium decreased 11.41 9.55 123 427582 19873 110141721
Gallbladder disorder 11.38 9.55 128 427577 20901 110140693
Pre-eclampsia 11.38 9.55 10 427695 8640 110152954
Atypical fracture 11.38 9.55 17 427688 1035 110160559
Duodenal neoplasm 11.37 9.55 6 427699 85 110161509
Lymphocyte stimulation test positive 11.33 9.55 17 427688 1039 110160555
Rectal ulcer haemorrhage 11.33 9.55 10 427695 341 110161253
Cardiac failure congestive 11.30 9.55 473 427232 150527 110011067
Blood loss anaemia 11.30 9.55 34 427671 17991 110143603
Withdrawal syndrome 11.26 9.55 73 427632 31307 110130287
Intentional product use issue 11.23 9.55 816 426889 247090 109914504
Concussion 11.22 9.55 17 427688 11521 110150073
Hypoglycaemia 11.21 9.55 553 427152 115551 110046043
Flashback 11.19 9.55 11 427694 431 110161163
Eosinophilic oesophagitis 11.16 9.55 19 427686 1293 110160301
Ulcer haemorrhage 11.16 9.55 135 427570 22436 110139158
Vascular skin disorder 11.15 9.55 4 427701 20 110161574
Congenital bowing of long bones 11.15 9.55 4 427701 20 110161574
Hysterectomy 11.14 9.55 9 427696 8105 110153489
Gastric ulcer haemorrhage 11.11 9.55 72 427633 10022 110151572
Violence-related symptom 11.10 9.55 16 427689 943 110160651
Biopsy muscle abnormal 11.09 9.55 5 427700 49 110161545
Overweight 11.08 9.55 52 427653 6412 110155182
Fasciitis 11.07 9.55 16 427689 945 110160649
Rapid eye movement sleep behaviour disorder 11.05 9.55 13 427692 626 110160968
Caesarean section 11.05 9.55 23 427682 13794 110147800
Venous thrombosis limb 11.05 9.55 45 427660 5220 110156374
Haemophagocytic lymphohistiocytosis 11.03 9.55 74 427631 31485 110130109
Pharyngeal inflammation 11.02 9.55 22 427683 1692 110159902
Antineutrophil cytoplasmic antibody positive 11.00 9.55 3 427702 5073 110156521
Putamen haemorrhage 10.98 9.55 12 427693 533 110161061
Flank pain 10.96 9.55 49 427656 23081 110138513
Lip blister 10.96 9.55 33 427672 3292 110158302
Urinary straining 10.83 9.55 5 427700 52 110161542
Infusion site pain 10.82 9.55 33 427672 17386 110144208
Skin irritation 10.80 9.55 30 427675 16289 110145305
Urine calcium/creatinine ratio increased 10.80 9.55 7 427698 148 110161446
Alanine aminotransferase increased 10.79 9.55 838 426867 182935 109978659
Autonomic neuropathy 10.78 9.55 26 427679 2274 110159320
Accidental death 10.78 9.55 3 427702 5006 110156588
Anaphylactic reaction 10.75 9.55 543 427162 113757 110047837
Peptic ulcer 10.74 9.55 58 427647 7561 110154033
Meniere's disease 10.72 9.55 7 427698 150 110161444
Foetal exposure during pregnancy 10.72 9.55 8 427697 7497 110154097
Strongyloidiasis 10.70 9.55 3 427702 4983 110156611
Nocardiosis 10.66 9.55 8 427697 7478 110154116
Amenorrhoea 10.62 9.55 12 427693 9219 110152375
Vaginal cellulitis 10.62 9.55 6 427699 98 110161496
Acute hepatic failure 10.61 9.55 90 427615 36378 110125216
Periorbital swelling 10.60 9.55 4 427701 5501 110156093
Spirometry abnormal 10.58 9.55 4 427701 5493 110156101
Hepatic atrophy 10.56 9.55 11 427694 462 110161132
Procedural failure 10.56 9.55 7 427698 154 110161440
Balanoposthitis 10.50 9.55 19 427686 1357 110160237
Anxiety 10.48 9.55 1505 426200 343573 109818021
Full blood count abnormal 10.47 9.55 153 427552 55899 110105695
Gestational diabetes 10.39 9.55 8 427697 7381 110154213
Diabetes mellitus 10.37 9.55 477 427228 98904 110062690
Depression 10.37 9.55 1390 426315 315945 109845649
Pure white cell aplasia 10.37 9.55 7 427698 159 110161435
Gastrostomy tube site complication 10.34 9.55 8 427697 226 110161368
Scleritis 10.34 9.55 4 427701 5416 110156178
Acanthosis 10.33 9.55 12 427693 570 110161024
Cytopenia 10.33 9.55 71 427634 30045 110131549
Product storage error 10.32 9.55 46 427659 21682 110139912
Pneumocystis jirovecii pneumonia 10.31 9.55 227 427478 42508 110119086
Product quality issue 10.31 9.55 224 427481 77075 110084519
Aortic aneurysm rupture 10.27 9.55 19 427686 1381 110160213
Hypersensitivity pneumonitis 10.27 9.55 44 427661 5221 110156373
Paranasal sinus discomfort 10.26 9.55 6 427699 6399 110155195
Constipation 10.22 9.55 1555 426150 356231 109805363
Granuloma 10.21 9.55 13 427692 9477 110152117
Dermatitis acneiform 10.21 9.55 84 427621 12611 110148983
Treatment noncompliance 10.17 9.55 210 427495 72780 110088814
Mycobacterium avium complex infection 10.16 9.55 5 427700 5872 110155722
Inflammatory bowel disease 10.16 9.55 55 427650 7179 110154415
Carotid artery stenosis 10.15 9.55 66 427639 9197 110152397
Dressler's syndrome 10.15 9.55 4 427701 27 110161567
Vulval haemorrhage 10.15 9.55 4 427701 27 110161567
Uterine perforation 10.15 9.55 7 427698 6833 110154761
Unintended pregnancy 10.12 9.55 3 427702 4805 110156789
Gastroenteritis staphylococcal 10.12 9.55 9 427696 310 110161284
Pulmonary embolism 10.08 9.55 962 426743 213512 109948082
Acute myocardial infarction 10.06 9.55 408 427297 83369 110078225
Tendon discomfort 10.02 9.55 12 427693 589 110161005
Dialysis 9.99 9.55 118 427587 19501 110142093
Narrow anterior chamber angle 9.92 9.55 7 427698 171 110161423
Injection site extravasation 9.87 9.55 15 427690 10154 110151440
Abulia 9.86 9.55 18 427687 1295 110160299
Rash papulosquamous 9.85 9.55 7 427698 173 110161421
Strangury 9.84 9.55 8 427697 243 110161351
Frequent bowel movements 9.84 9.55 353 427352 71037 110090557
Irritability 9.83 9.55 128 427577 47681 110113913
Alanine aminotransferase abnormal 9.82 9.55 13 427692 9321 110152273
Respiratory muscle weakness 9.80 9.55 10 427695 410 110161184
Incision site complication 9.78 9.55 14 427691 820 110160774
Coagulation test abnormal 9.77 9.55 20 427685 1566 110160028
Neoplasm recurrence 9.75 9.55 4 427701 5228 110156366
Burning feet syndrome 9.73 9.55 8 427697 247 110161347
Nasal mucosal erosion 9.72 9.55 5 427700 67 110161527
Abortion induced 9.70 9.55 10 427695 8009 110153585
Metastases to lymph nodes 9.68 9.55 28 427677 15004 110146590
Nephrolithiasis 9.68 9.55 189 427516 66023 110095571
Pressure of speech 9.67 9.55 18 427687 1314 110160280
Renal tubular acidosis 9.66 9.55 40 427665 4675 110156919
Bacteroides infection 9.65 9.55 29 427676 2890 110158704
Gastrooesophageal reflux disease 9.65 9.55 815 426890 179161 109982433
Sinus node dysfunction 9.64 9.55 64 427641 8983 110152611
Prothrombin time ratio increased 9.63 9.55 9 427696 331 110161263
Multiple organ dysfunction syndrome 9.61 9.55 696 427009 151014 110010580
Diabetic metabolic decompensation 9.60 9.55 35 427670 3854 110157740
Gallbladder hypofunction 9.60 9.55 11 427694 515 110161079
Renal artery stenosis 9.60 9.55 34 427671 3692 110157902
Oropharyngeal swelling 9.57 9.55 19 427686 1455 110160139
Eosinophil count increased 9.57 9.55 124 427581 20934 110140660
Increased appetite 9.57 9.55 28 427677 14949 110146645
Paramnesia 9.57 9.55 4 427701 32 110161562

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BC03 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Proton pump inhibitors
ATC A02BC53 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Proton pump inhibitors
ATC A02BD02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
ATC A02BD03 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
ATC A02BD07 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
ATC A02BD09 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
ATC A02BD10 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
FDA MoA N0000000147 Proton Pump Inhibitors
FDA PE N0000009724 Inhibition Gastric Acid Secretion
FDA EPC N0000175525 Proton Pump Inhibitor
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35845 gout suppressant
CHEBI has role CHEBI:49200 EC 3.6.3.10 (<em>H</em><small><sup>+</small></sup>/<em>K</em><small><sup>+</small></sup>-exchanging ATPase) inhibitor
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:233423 antifibrotic agent
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054328 Proton Pump Inhibitors

Related Drugs by ATC class:

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A02BD Combinations for eradication of Helicobacter pylori 13 drugs
amoxicillinbismuth subcitrateclarithromycinesomeprazolelevofloxacinmetronidazoleomeprazolepantoprazolerabeprazolerifabutintetracyclinetinidazole show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Erosive esophagitis indication 40719004
Duodenal ulcer disease indication 51868009 DOID:1724
Zollinger-Ellison syndrome indication 53132006 DOID:0050782
Gastroesophageal reflux disease indication 235595009 DOID:8534
Gastric ulcer indication 397825006 DOID:10808
NSAID-Induced Gastric Ulcer indication
Gastric Hypersecretory Conditions indication
Duodenal Ulcer due to H. Pylori indication
Maintenance of Healing Duodenal Ulcer indication
Upper gastrointestinal hemorrhage off-label use 37372002
Pathological Gastric Hypersecretory Condition off-label use
Prevention of Stress Ulcer off-label use
Prevention of Acute Gastrointestinal Ulcer Re-Bleed off-label use
Alcoholism contraindication 7200002
Myocardial infarction contraindication 22298006 DOID:5844
Ventricular tachycardia contraindication 25569003
Obstruction of bile duct contraindication 30144000
Torsades de pointes contraindication 31722008
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Osteoporosis contraindication 64859006 DOID:11476
Gastrointestinal hemorrhage contraindication 74474003
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Cholestatic hepatitis contraindication 95556007
Prolonged QT interval contraindication 111975006
Fracture of bone contraindication 125605004
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Cerebrovascular accident contraindication 230690007
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Esophageal dysmotility contraindication 266434009 DOID:9192
Edema contraindication 267038008
Infectious mononucleosis contraindication 271558008 DOID:8568
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thromboembolic disorder contraindication 371039008
Cardiovascular event risk contraindication 395112001
Pseudomembranous enterocolitis contraindication 397683000
Porphyria contraindication 418470004
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.23 acidic
pKa2 3.35 Basic
pKa3 2.72 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Potassium-transporting ATPase Transporter INHIBITOR CHEMBL CHEMBL
Peptidyl-prolyl cis-trans isomerase A Enzyme IC50 6.12 CHEMBL
ATP-binding cassette sub-family G member 2 Transporter IC50 4.84 CHEMBL
Cytochrome P450 2C19 Enzyme IC50 6.47 DRUG MATRIX
Fatty acid synthase Enzyme Ki 5.28 CHEMBL
Phosphoethanolamine/phosphocholine phosphatase Enzyme IC50 6.36 CHEMBL
Microtubule-associated protein tau Structural Ki 8.60 CHEMBL
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Enzyme IC50 4.29 CHEMBL
Cytochrome P450 2D6 Enzyme IC50 5.28 DRUG MATRIX
Cytosolic endo-beta-N-acetylglucosaminidase Enzyme IC50 4.61 CHEMBL
Indoleamine 2,3-dioxygenase 2 Enzyme IC50 5.09 CHEMBL
Indoleamine 2,3-dioxygenase 1 Enzyme IC50 4.03 CHEMBL

External reference:

IDSource
D00355 KEGG_DRUG
4020922 VANDF
C0050940 UMLSCUI
CHEMBL480 ChEMBL_ID
DB00448 DRUGBANK_ID
D064747 MESH_DESCRIPTOR_UI
3883 PUBCHEM_CID
7208 IUPHAR_LIGAND_ID
6397 INN_ID
0K5C5T2QPG UNII
17128 RXNORM
169151 MMSL
330 MMSL
4958 MMSL
d03828 MMSL
004456 NDDF
108666007 SNOMEDCT_US
386888004 SNOMEDCT_US
CHEBI:6375 CHEBI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lansoprazole HUMAN PRESCRIPTION DRUG LABEL 1 0093-3008 TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE 15 mg ORAL ANDA 29 sections
Lansoprazole HUMAN PRESCRIPTION DRUG LABEL 1 0093-3009 TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE 30 mg ORAL ANDA 29 sections
Lansoprazole HUMAN PRESCRIPTION DRUG LABEL 1 0093-7350 CAPSULE, DELAYED RELEASE 15 mg ORAL ANDA 27 sections
Lansoprazole HUMAN PRESCRIPTION DRUG LABEL 1 0093-7351 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 27 sections
Good Sense Lansoprazole HUMAN OTC DRUG LABEL 1 0113-0116 TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE 15 mg ORAL NDA 15 sections
Good Sense Lansoprazole HUMAN OTC DRUG LABEL 1 0113-1114 CAPSULE, DELAYED RELEASE 15 mg ORAL ANDA 15 sections
Prevacid 24 HR HUMAN OTC DRUG LABEL 1 0113-6117 CAPSULE, DELAYED RELEASE 15 mg ORAL ANDA 15 sections
Lansoprazole HUMAN OTC DRUG LABEL 1 0363-0037 CAPSULE, DELAYED RELEASE 15 mg ORAL ANDA 15 sections
lansoprazole HUMAN OTC DRUG LABEL 1 0363-1212 CAPSULE, DELAYED RELEASE 15 mg ORAL ANDA 15 sections
Lansoprazole HUMAN OTC DRUG LABEL 1 0363-1419 TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE 15 mg ORAL NDA 15 sections
Lansoprazole HUMAN PRESCRIPTION DRUG LABEL 1 0378-6981 TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE 15 mg ORAL ANDA 28 sections
Lansoprazole HUMAN PRESCRIPTION DRUG LABEL 1 0378-6982 TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE 30 mg ORAL ANDA 28 sections
Lansoprazole HUMAN PRESCRIPTION DRUG LABEL 1 0378-8015 CAPSULE, DELAYED RELEASE PELLETS 15 mg ORAL ANDA 29 sections
Lansoprazole HUMAN PRESCRIPTION DRUG LABEL 1 0378-8030 CAPSULE, DELAYED RELEASE PELLETS 30 mg ORAL ANDA 29 sections
Lansoprazole HUMAN OTC DRUG LABEL 1 0536-1368 CAPSULE, DELAYED RELEASE 15 mg ORAL ANDA 15 sections
Lansoprazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-6662 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 27 sections
up and up lansoprazole HUMAN OTC DRUG LABEL 1 11673-280 CAPSULE, DELAYED RELEASE 15 mg ORAL ANDA 15 sections
Lansoprazole HUMAN OTC DRUG LABEL 1 11673-324 CAPSULE, DELAYED RELEASE 15 mg ORAL ANDA 15 sections
Lansoprazole HUMAN OTC DRUG LABEL 1 11822-0019 CAPSULE, DELAYED RELEASE 15 mg ORAL ANDA 15 sections
Lansoprazole HUMAN OTC DRUG LABEL 1 11822-3374 CAPSULE, DELAYED RELEASE 15 mg ORAL ANDA 15 sections
Lansoprazole Human Prescription Drug Label 1 16571-697 CAPSULE, DELAYED RELEASE 15 mg ORAL ANDA 26 sections
Lansoprazole Human Prescription Drug Label 1 16571-698 CAPSULE, DELAYED RELEASE 30 mg ORAL ANDA 26 sections
Lansoprazole Human OTC Drug Label 1 16571-742 CAPSULE, DELAYED RELEASE 15 mg ORAL ANDA 15 sections
LANSOPRAZOLE HUMAN PRESCRIPTION DRUG LABEL 1 16590-890 CAPSULE, DELAYED RELEASE 15 mg ORAL NDA authorized generic 32 sections
LANSOPRAZOLE HUMAN PRESCRIPTION DRUG LABEL 1 16590-891 CAPSULE, DELAYED RELEASE 30 mg ORAL NDA authorized generic 32 sections
Lansoprazole HUMAN PRESCRIPTION DRUG LABEL 1 16714-185 TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE 15 mg ORAL ANDA 28 sections
Lansoprazole HUMAN PRESCRIPTION DRUG LABEL 1 16714-186 TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE 30 mg ORAL ANDA 28 sections
Lansoprazole HUMAN OTC DRUG LABEL 1 21130-019 CAPSULE, DELAYED RELEASE 15 mg ORAL ANDA 15 sections
Lansoprazole HUMAN OTC DRUG LABEL 1 21130-046 CAPSULE, DELAYED RELEASE 15 mg ORAL ANDA 15 sections
Prevacid SoluTab HUMAN PRESCRIPTION DRUG LABEL 1 21695-106 TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE 30 mg ORAL NDA 32 sections