lansoprazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antiulcer, benzimidazole derivatives	1547	103577-45-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: prevacid lansoprazole A-65006 AG 1749 AG-1749	A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers. Molecular weight: 369.36 Formula: C16H14F3N3O2S CLOGP: 2.79 LIPINSKI: 0 HAC: 5 HDO: 1 TPSA: 67.87 ALOGS: -3.17 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

prevacid
lansoprazole
A-65006
AG 1749
AG-1749

A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.

Molecular weight: 369.36
Formula: C16H14F3N3O2S
CLOGP: 2.79
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 67.87
ALOGS: -3.17
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
30	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.00 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	1.35 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	81 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.28 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	4.40 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.02 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	1 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
May 10, 1995	FDA	TAKEDA PHARMS USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Chronic kidney disease	948.67	9.36	908	182282	41148	56067729
Drug ineffective	663.90	9.36	1244	181946	917745	55191132
Hyponatraemia	414.25	9.36	981	182209	101158	56007719
Renal injury	409.96	9.36	291	182899	8596	56100281
Colitis microscopic	358.96	9.36	256	182934	7619	56101258
Acute kidney injury	337.82	9.36	1614	181576	239149	55869728
End stage renal disease	309.69	9.36	212	182978	5899	56102978
Rheumatoid arthritis	292.28	9.36	498	182692	382106	55726771
Completed suicide	269.20	9.36	54	183136	133779	55975098
Drug intolerance	233.62	9.36	312	182878	264506	55844371
Contraindicated product administered	210.59	9.36	178	183012	186108	55922769
Hypomagnesaemia	191.44	9.36	314	182876	24701	56084176
Fatigue	185.79	9.36	1659	181531	786893	55321984
Therapeutic product effect incomplete	185.64	9.36	57	183133	105974	56002903
Product dose omission issue	176.68	9.36	245	182945	204508	55904369
Pain	170.06	9.36	1364	181826	661820	55447057
Off label use	162.05	9.36	1103	182087	555077	55553800
Renal failure	160.59	9.36	749	182441	109751	55999126
Arthropathy	159.78	9.36	253	182937	200022	55908855
Alopecia	155.29	9.36	466	182724	292992	55815885
Subacute cutaneous lupus erythematosus	154.58	9.36	96	183094	2253	56106624
Death	150.94	9.36	586	182604	340840	55768037
Pemphigus	149.19	9.36	175	183015	157037	55951840
Treatment failure	143.87	9.36	207	182983	170185	55938692
Maternal exposure during pregnancy	140.53	9.36	251	182939	189302	55919575
Synovitis	140.13	9.36	192	182998	161113	55947764
Systemic lupus erythematosus	133.90	9.36	238	182952	179840	55929037
Joint swelling	125.08	9.36	502	182688	289298	55819579
Therapeutic product effect decreased	120.60	9.36	230	182960	169222	55939655
Hypertensive nephropathy	119.72	9.36	50	183140	484	56108393
Hepatic function abnormal	107.89	9.36	301	182889	34257	56074620
Neutropenic sepsis	107.36	9.36	184	183006	15001	56093876
Cerebral infarction	104.23	9.36	228	182962	22277	56086600
Interstitial lung disease	102.96	9.36	413	182777	56650	56052227
Gastrooesophageal reflux disease	101.49	9.36	537	182653	82720	56026157
Abdominal discomfort	100.62	9.36	512	182678	276762	55832115
Melaena	98.97	9.36	257	182933	28033	56080844
Hand deformity	98.82	9.36	179	183011	134313	55974564
Toxicity to various agents	98.74	9.36	386	182804	224178	55884699
Product use issue	98.60	9.36	295	182895	185746	55923131
Exposure during pregnancy	97.92	9.36	184	183006	136158	55972719
Glossodynia	94.22	9.36	224	182966	152234	55956643
Renal impairment	91.90	9.36	511	182679	80202	56028675
Hypokalaemia	91.49	9.36	573	182617	93864	56015013
Abdominal pain	89.45	9.36	1258	181932	257547	55851330
Haematemesis	89.30	9.36	250	182940	28508	56080369
Chest pain	86.73	9.36	972	182218	188825	55920052
Electric shock	85.63	9.36	50	183140	1045	56107832
Injection site pain	80.67	9.36	162	183028	116956	55991921
Swollen tongue	80.21	9.36	249	182941	30075	56078802
Arthralgia	76.43	9.36	1161	182029	500508	55608369
Tubulointerstitial nephritis	76.22	9.36	168	183022	16497	56092380
Swelling	75.38	9.36	464	182726	239307	55869570
Device expulsion	73.56	9.36	7	183183	30442	56078435
Nephrogenic anaemia	73.48	9.36	56	183134	1848	56107029
Diabetic nephropathy	73.11	9.36	49	183141	1315	56107562
Cholecystitis chronic	72.73	9.36	121	183069	9627	56099250
Electrocardiogram QT prolonged	69.20	9.36	356	182834	54232	56054645
Loss of personal independence in daily activities	67.49	9.36	100	183090	81269	56027608
Nephropathy	67.12	9.36	87	183103	5522	56103355
Psoriasis	65.74	9.36	126	183064	92566	56016311
Sinusitis	64.91	9.36	377	182813	197204	55911673
Peripheral swelling	64.87	9.36	472	182718	234254	55874623
Anti-cyclic citrullinated peptide antibody positive	64.85	9.36	140	183050	98460	56010417
Hypocalcaemia	63.38	9.36	222	182968	28538	56080339
Infective pulmonary exacerbation of cystic fibrosis	60.52	9.36	101	183089	8056	56100821
Labile blood pressure	59.27	9.36	47	183143	1646	56107231
Rebound acid hypersecretion	59.01	9.36	26	183164	290	56108587
Drug hypersensitivity	58.77	9.36	592	182598	274613	55834264
Infusion related reaction	58.75	9.36	418	182772	208513	55900364
Drug abuse	58.13	9.36	81	183109	67529	56041348
Wound	57.55	9.36	244	182946	138560	55970317
Hepatic enzyme increased	57.36	9.36	325	182865	171059	55937818
Gastritis	56.19	9.36	243	182947	34459	56074418
Cholestasis	56.11	9.36	204	182986	26709	56082168
Confusional state	55.54	9.36	969	182221	207186	55901691
Faeces discoloured	53.99	9.36	149	183041	16847	56092030
Angioedema	53.00	9.36	271	182919	41182	56067695
Weight increased	52.89	9.36	485	182705	229218	55879659
Intervertebral discitis	52.88	9.36	55	183135	2752	56106125
Hepatocellular injury	52.78	9.36	198	182992	26316	56082561
Agranulocytosis	51.75	9.36	177	183013	22482	56086395
COVID-19	51.51	9.36	104	183086	74954	56033923
Foetal exposure during pregnancy	51.08	9.36	23	183167	33800	56075077
Sopor	50.95	9.36	167	183023	20755	56088122
International normalised ratio increased	50.89	9.36	280	182910	43761	56065116
Lip swelling	50.49	9.36	194	182996	26078	56082799
Vomiting	50.40	9.36	2040	181150	496188	55612689
Swelling face	48.66	9.36	331	182859	55738	56053139
Lethargy	48.47	9.36	310	182880	51131	56057746
Rectal haemorrhage	48.16	9.36	264	182926	41203	56067674
Discomfort	47.87	9.36	268	182922	141493	55967384
Anaemia	46.69	9.36	1170	182020	266341	55842536
Accidental exposure to product	45.42	9.36	12	183178	24635	56084242
Dysphagia	45.09	9.36	436	182754	81511	56027366
Urticaria	45.07	9.36	691	182499	143985	55964892
Lower respiratory tract infection	44.94	9.36	571	182619	114223	55994654
Liver function test abnormal	44.75	9.36	278	182912	45393	56063484
Hyperglycaemia	43.97	9.36	243	182947	38038	56070839
Brain stem glioma	42.73	9.36	19	183171	217	56108660
Biliary dyskinesia	42.61	9.36	47	183143	2516	56106361
Neutrophil count decreased	42.56	9.36	293	182897	49529	56059348
Drug interaction	41.96	9.36	935	182255	208820	55900057
Jaundice	41.81	9.36	188	183002	27106	56081771
Injection site pruritus	41.56	9.36	45	183145	41886	56066991
Circulatory collapse	41.12	9.36	155	183035	20648	56088229
Injection site reaction	40.78	9.36	69	183121	53178	56055699
Upper respiratory tract inflammation	40.45	9.36	45	183145	2432	56106445
Coordination abnormal	40.44	9.36	111	183079	12510	56096367
Coma scale abnormal	39.87	9.36	63	183127	4800	56104077
Injection site swelling	39.71	9.36	50	183140	43528	56065349
Therapy interrupted	39.37	9.36	17	183173	25608	56083269
Anaphylactic reaction	39.18	9.36	327	182863	58668	56050209
Rheumatoid factor positive	39.12	9.36	106	183084	68954	56039923
Post-traumatic stress disorder	38.89	9.36	60	183130	4478	56104399
Hypophosphataemic osteomalacia	38.21	9.36	16	183174	156	56108721
Basilar artery occlusion	37.69	9.36	14	183176	96	56108781
Nasopharyngitis	37.52	9.36	500	182690	220459	55888418
Hepatic ischaemia	37.52	9.36	24	183166	594	56108283
Nephrocalcinosis	37.31	9.36	29	183161	986	56107891
Reflux gastritis	37.12	9.36	30	183160	1080	56107797
Pericarditis	36.72	9.36	206	182984	108717	56000160
Injection site erythema	36.01	9.36	130	183060	77318	56031559
Hypersensitivity	35.70	9.36	603	182587	255805	55853072
Renal tubular acidosis	35.10	9.36	34	183156	1561	56107316
Blood alkaline phosphatase increased	35.04	9.36	232	182958	38713	56070164
Hepatorenal syndrome	34.90	9.36	36	183154	1784	56107093
Red blood cell sedimentation rate abnormal	34.59	9.36	9	183181	18664	56090213
Facet joint syndrome	34.51	9.36	71	183119	6646	56102231
Coronary artery disease	34.38	9.36	194	182996	30602	56078275
Disseminated intravascular coagulation	34.31	9.36	132	183058	17753	56091124
Oesophagitis	34.04	9.36	112	183078	13945	56094932
Deep vein thrombosis postoperative	34.03	9.36	53	183137	3988	56104889
Wrong technique in product usage process	33.92	9.36	88	183102	58080	56050797
Inappropriate schedule of product administration	33.68	9.36	148	183042	83239	56025638
Urine magnesium decreased	33.12	9.36	7	183183	0	56108877
Skin candida	33.08	9.36	31	183159	1365	56107512
Erythema multiforme	32.60	9.36	86	183104	9468	56099409
Lip dry	32.55	9.36	87	183103	9653	56099224
Mobility decreased	32.41	9.36	189	183001	98802	56010075
Hyperkalaemia	32.22	9.36	279	182911	50586	56058291
Therapeutic response decreased	32.17	9.36	78	183112	52680	56056197
Therapy cessation	32.07	9.36	25	183165	27239	56081638
Adrenal insufficiency	31.89	9.36	118	183072	15579	56093298
Suicide attempt	31.84	9.36	90	183100	57746	56051131
Somatic delusion	31.75	9.36	21	183169	551	56108326
Syncope	31.49	9.36	511	182679	107688	56001189
Blood sodium decreased	31.38	9.36	150	183040	22184	56086693
Demyelination	30.78	9.36	65	183125	6197	56102680
Hypergastrinaemia	30.72	9.36	12	183178	96	56108781
Intentional overdose	30.58	9.36	116	183074	68001	56040876
Abortion spontaneous	30.55	9.36	60	183130	43693	56065184
Pemphigoid	30.51	9.36	65	183125	6235	56102642
Hospitalisation	30.36	9.36	133	183057	74867	56034010
Device dislocation	30.23	9.36	18	183172	22588	56086289
Decreased appetite	30.10	9.36	930	182260	218301	55890576
Altered state of consciousness	29.77	9.36	151	183039	22870	56086007
Haemorrhage subcutaneous	29.66	9.36	41	183149	2769	56106108
Drug resistance	29.44	9.36	15	183175	20527	56088350
Drug reaction with eosinophilia and systemic symptoms	29.40	9.36	184	183006	30120	56078757
Intentional product use issue	29.25	9.36	197	182993	99536	56009341
Post viral fatigue syndrome	29.18	9.36	16	183174	295	56108582
Pneumonia bacterial	29.18	9.36	74	183116	7954	56100923
Hiatus hernia	29.09	9.36	134	183056	19518	56089359
Liver disorder	28.96	9.36	245	182945	44125	56064752
Subarachnoid haemorrhage	28.92	9.36	92	183098	11255	56097622
Psoriatic arthropathy	28.90	9.36	133	183057	73875	56035002
Dry mouth	28.90	9.36	328	182862	63877	56045000
Iron deficiency anaemia	28.64	9.36	125	183065	17794	56091083
Deep vein thrombosis	28.48	9.36	379	182811	76598	56032279
Urine phosphorus decreased	28.39	9.36	6	183184	0	56108877
Temperature intolerance	28.07	9.36	73	183117	7967	56100910
Pituitary tumour benign	28.06	9.36	33	183157	1895	56106982
Platelet count decreased	27.89	9.36	494	182696	105889	56002988
Progressive multifocal leukoencephalopathy	27.57	9.36	94	183096	11919	56096958
Hyperchlorhydria	27.51	9.36	30	183160	1585	56107292
Cardiac failure	27.46	9.36	397	182793	81696	56027181
Urine potassium decreased	27.36	9.36	7	183183	9	56108868
Gastrointestinal haemorrhage	27.30	9.36	372	182818	75579	56033298
Urine output decreased	27.12	9.36	87	183103	10690	56098187
Gastric polyps	27.01	9.36	42	183148	3156	56105721
Macular degeneration	26.81	9.36	14	183176	18894	56089983
Condition aggravated	26.30	9.36	889	182301	344009	55764868
Haematuria	26.26	9.36	164	183026	26823	56082054
Peripheral venous disease	25.94	9.36	82	183108	9997	56098880
Rectal ulcer	25.93	9.36	25	183165	1141	56107736
Upper gastrointestinal haemorrhage	25.77	9.36	117	183073	16937	56091940
Premature delivery	25.77	9.36	30	183160	27030	56081847
Red blood cell sedimentation rate increased	25.76	9.36	50	183140	36573	56072304
Renal atrophy	25.71	9.36	27	183163	1366	56107511
Angina pectoris	25.37	9.36	167	183023	27809	56081068
Toxic skin eruption	25.33	9.36	90	183100	11649	56097228
Gastric ulcer	25.10	9.36	142	183048	22421	56086456
Drug ineffective for unapproved indication	24.99	9.36	28	183162	25665	56083212
Dermatitis exfoliative	24.89	9.36	54	183136	5245	56103632
Erythema dyschromicum perstans	24.83	9.36	9	183181	57	56108820
Injury	24.39	9.36	300	182890	59551	56049326
Mixed liver injury	24.29	9.36	45	183145	3899	56104978
Crohn's disease	24.15	9.36	60	183130	6367	56102510
Dysuria	24.08	9.36	177	183013	30552	56078325
Gallbladder disorder	24.05	9.36	116	183074	17218	56091659
Adverse drug reaction	23.71	9.36	120	183070	65012	56043865
Cerebral haemorrhage	23.70	9.36	167	183023	28439	56080438
Hypersensitivity pneumonitis	23.42	9.36	34	183156	2403	56106474
Pancreatitis	23.40	9.36	237	182953	44843	56064034
Laryngeal pain	23.34	9.36	46	183144	4174	56104703
Dyspepsia	23.09	9.36	391	182799	83080	56025797
Product use in unapproved indication	23.04	9.36	321	182869	140501	55968376
Hyperprolactinaemia	22.84	9.36	42	183148	3619	56105258
Dermatitis bullous	22.69	9.36	65	183125	7508	56101369
Dehydration	22.65	9.36	677	182513	158148	55950729
Infection	22.57	9.36	488	182702	199718	55909159
Orthostatic hypotension	22.56	9.36	185	183005	33014	56075863
Abnormal loss of weight	22.53	9.36	52	183138	5264	56103613
Neuropathy, ataxia, retinitis pigmentosa syndrome	22.44	9.36	8	183182	48	56108829
Hyperparathyroidism secondary	22.43	9.36	25	183165	1354	56107523
Foot deformity	22.06	9.36	27	183163	23798	56085079
Muscle relaxant therapy	22.02	9.36	11	183179	166	56108711
Injection site bruising	21.91	9.36	59	183131	38462	56070415
Bradycardia	21.61	9.36	324	182866	67180	56041697
Nasal congestion	21.59	9.36	102	183088	56268	56052609
Product storage error	21.55	9.36	8	183182	13205	56095672
Inappropriate antidiuretic hormone secretion	21.25	9.36	95	183095	13661	56095216
Joint stiffness	21.11	9.36	53	183137	35372	56073505
Flashback	21.07	9.36	10	183180	134	56108743
Oropharyngeal oedema	21.05	9.36	13	183177	302	56108575
Oedema peripheral	21.03	9.36	717	182473	170537	55938340
Blood lactic acid	20.95	9.36	9	183181	94	56108783
Oesophageal mucosal tear	20.92	9.36	6	183184	15	56108862
Sedation	20.88	9.36	52	183138	34802	56074075
Hepatotoxicity	20.66	9.36	44	183146	31109	56077768
Rapid eye movement sleep behaviour disorder	20.65	9.36	11	183179	191	56108686
Gastric dysplasia	20.64	9.36	6	183184	16	56108861
Acne	20.59	9.36	23	183167	21113	56087764
Multiple sclerosis relapse	20.46	9.36	76	183114	44827	56064050
Cholecystitis	20.32	9.36	97	183093	14338	56094539
Pneumocystis jirovecii pneumonia	20.31	9.36	103	183087	15598	56093279
Pressure of speech	20.31	9.36	16	183174	555	56108322
Eosinophilia	20.16	9.36	123	183067	19954	56088923
Malaise	20.05	9.36	1422	181768	366438	55742439
Blood pressure decreased	19.91	9.36	286	182904	58764	56050113
Aphasia	19.87	9.36	168	183022	30247	56078630
Carcinoid tumour of the stomach	19.84	9.36	10	183180	154	56108723
Cholelithiasis	19.78	9.36	206	182984	39258	56069619
Dialysis	19.76	9.36	73	183117	9629	56099248
Rheumatoid nodule	19.63	9.36	12	183178	14845	56094032
Chromaturia	19.45	9.36	100	183090	15225	56093652
Aspiration	19.27	9.36	72	183118	9549	56099328
Diarrhoea	19.21	9.36	2365	180825	636142	55472735
Alanine aminotransferase increased	19.17	9.36	419	182771	93243	56015634
Activated partial thromboplastin time prolonged	19.08	9.36	56	183134	6556	56102321
Full blood count decreased	19.06	9.36	29	183161	23320	56085557
Product substitution issue	19.04	9.36	96	183094	14503	56094374
No adverse event	19.01	9.36	58	183132	36316	56072561
Stress	19.00	9.36	113	183077	58797	56050080
Superinfection	18.85	9.36	29	183161	2159	56106718
Gastrointestinal motility disorder	18.82	9.36	45	183145	4661	56104216
Purpura	18.68	9.36	75	183115	10287	56098590
Hypocalciuria	18.54	9.36	5	183185	9	56108868
Anal prolapse	18.50	9.36	8	183182	85	56108792
Hypoglycaemic coma	18.49	9.36	30	183160	2337	56106540
Enterocolitis	18.47	9.36	58	183132	7046	56101831
Device difficult to use	18.44	9.36	6	183184	10755	56098122
Infusion site streaking	18.42	9.36	14	183176	460	56108417
Abdominal pain upper	18.37	9.36	732	182458	177581	55931296
Neoplasm progression	18.23	9.36	49	183141	31967	56076910
Injection site warmth	18.14	9.36	12	183178	14231	56094646
Stoma site haemorrhage	18.13	9.36	19	183171	959	56107918
Poisoning deliberate	18.05	9.36	5	183185	9948	56098929
Gastric cancer	18.04	9.36	40	183150	3943	56104934
Enteritis infectious	17.88	9.36	27	183163	1977	56106900
Mediastinitis	17.88	9.36	10	183180	192	56108685
Cholecystitis acute	17.88	9.36	59	183131	7357	56101520
Face oedema	17.87	9.36	112	183078	18340	56090537
Enterochromaffin cell hyperplasia	17.81	9.36	7	183183	57	56108820
Wheezing	17.78	9.36	343	182847	74683	56034194
Biliary sepsis	17.71	9.36	18	183172	876	56108001
Autoimmune disorder	17.70	9.36	67	183123	8942	56099935
Rash erythematous	17.59	9.36	192	182998	37029	56071848
Intestinal ischaemia	17.37	9.36	56	183134	6899	56101978
Genitourinary symptom	17.20	9.36	7	183183	63	56108814
Deformity	17.08	9.36	6	183184	10249	56098628
Pancreatitis acute	17.07	9.36	140	183050	24984	56083893
Vulvovaginal candidiasis	17.07	9.36	33	183157	2953	56105924
Palpitations	17.06	9.36	435	182755	99237	56009640
Excessive eye blinking	17.03	9.36	19	183171	1030	56107847
Haemoptysis	16.98	9.36	146	183044	26414	56082463
Azotaemia	16.89	9.36	40	183150	4118	56104759
Gallbladder injury	16.88	9.36	21	183169	1279	56107598
Blood triglycerides increased	16.82	9.36	79	183111	11598	56097279
Eye haemorrhage	16.79	9.36	60	183130	7787	56101090
Musculoskeletal stiffness	16.79	9.36	383	182807	155624	55953253
Non-economic loss	16.77	9.36	5	183185	15	56108862
Enthesopathy	16.74	9.36	3	183187	8060	56100817
Hyponatraemic syndrome	16.72	9.36	14	183176	530	56108347
Influenza	16.72	9.36	214	182976	95047	56013830
Generalised bullous fixed drug eruption	16.65	9.36	7	183183	69	56108808
Hypochloraemia	16.62	9.36	24	183166	1688	56107189
Gastroenteritis	16.57	9.36	136	183054	24276	56084601
Ileus	16.53	9.36	89	183101	13793	56095084
Hypophosphataemia	16.52	9.36	69	183121	9633	56099244
Musculoskeletal disorder	16.39	9.36	23	183167	19124	56089753
Blood pressure increased	16.31	9.36	354	182836	144822	55964055
Acute coronary syndrome	16.27	9.36	69	183121	9699	56099178
Nightmare	16.21	9.36	102	183088	16724	56092153
Ulcer	16.20	9.36	127	183063	22358	56086519
Mouth swelling	16.20	9.36	39	183151	4058	56104819
Foetal death	16.17	9.36	4	183186	8583	56100294
Neuropathy peripheral	16.16	9.36	444	182746	102449	56006428
Total lung capacity decreased	16.13	9.36	22	183168	1467	56107410
Inflammatory bowel disease	16.13	9.36	37	183153	3731	56105146
Myocardial ischaemia	16.04	9.36	80	183110	12036	56096841
Panniculitis	15.98	9.36	6	183184	9836	56099041
Pulmonary embolism	15.91	9.36	459	182731	106665	56002212
Cardioactive drug level increased	15.86	9.36	26	183164	2043	56106834
Knee arthroplasty	15.85	9.36	82	183108	44177	56064700
Narrow anterior chamber angle	15.69	9.36	6	183184	45	56108832
Genital ulceration	15.64	9.36	13	183177	487	56108390
Product quality issue	15.60	9.36	52	183138	31684	56077193
Secondary adrenocortical insufficiency	15.54	9.36	20	183170	1260	56107617
Sinus bradycardia	15.44	9.36	86	183104	13500	56095377
Transient ischaemic attack	15.31	9.36	172	183018	33405	56075472
Dizziness	15.31	9.36	1422	181768	374718	55734159
Emotional distress	15.22	9.36	156	183034	29607	56079270
Pain in extremity	15.19	9.36	802	182388	296629	55812248
Respiratory arrest	15.18	9.36	50	183140	30575	56078302
Oral mucosal discolouration	15.03	9.36	11	183179	341	56108536
Hallucination	15.00	9.36	234	182956	48915	56059962
Erythema annulare	14.94	9.36	7	183183	91	56108786
Vascular skin disorder	14.90	9.36	4	183186	7	56108870
Lung opacity	14.78	9.36	27	183163	2314	56106563
Hemiparesis	14.73	9.36	120	183070	21370	56087507
Rhinorrhoea	14.63	9.36	117	183073	56920	56051957
Palmar erythema	14.63	9.36	22	183168	1605	56107272
Hypophagia	14.60	9.36	151	183039	28725	56080152
Asthma	14.56	9.36	475	182715	112295	55996582
Paramnesia	14.56	9.36	4	183186	8	56108869
Gastrointestinal stoma output decreased	14.56	9.36	6	183184	56	56108821
Haemodialysis	14.55	9.36	61	183129	8530	56100347
Immune thrombocytopenia	14.52	9.36	66	183124	9559	56099318
Intentional self-injury	14.42	9.36	38	183152	24954	56083923
Oesophageal carcinoma recurrent	14.31	9.36	5	183185	28	56108849
Pleuritic pain	14.29	9.36	53	183137	7004	56101873
Aortic valve calcification	14.27	9.36	12	183178	457	56108420
Nervous system disorder	14.23	9.36	99	183091	16790	56092087
Urine output	14.19	9.36	3	183187	0	56108877
Renal cyst	14.17	9.36	64	183126	9245	56099632
Hip fracture	14.10	9.36	43	183147	26930	56081947
Sleep disorder due to a general medical condition	14.01	9.36	6	183184	9084	56099793
Colon cancer	14.00	9.36	65	183125	9496	56099381
White blood cell count increased	14	9.36	214	182976	44545	56064332
Renal haemangioma	13.89	9.36	5	183185	31	56108846
Blood urea increased	13.84	9.36	131	183059	24342	56084535
Dermatitis psoriasiform	13.81	9.36	23	183167	1831	56107046
Multiple organ dysfunction syndrome	13.80	9.36	245	182945	52525	56056352
Tooth hypoplasia	13.77	9.36	6	183184	65	56108812
Phyllodes tumour	13.75	9.36	5	183185	32	56108845
Pleural effusion	13.74	9.36	370	182820	85110	56023767
Hepatic cytolysis	13.73	9.36	71	183119	10835	56098042
Coagulopathy	13.65	9.36	106	183084	18610	56090267
Bronchopulmonary aspergillosis allergic	13.65	9.36	20	183170	1426	56107451
Bradyphrenia	13.64	9.36	50	183140	6570	56102307
Pyrexia	13.60	9.36	1559	181631	417214	55691663
Urine calcium/creatinine ratio increased	13.59	9.36	7	183183	113	56108764
Atypical fracture	13.53	9.36	13	183177	591	56108286
Osteonecrosis	13.50	9.36	125	183065	23090	56085787
Cholangitis	13.42	9.36	41	183149	4908	56103969
Device dependence	13.42	9.36	4	183186	12	56108865
Fluid retention	13.38	9.36	112	183078	53966	56054911
Spleen congestion	13.38	9.36	7	183183	117	56108760
Laryngotracheal oedema	13.37	9.36	5	183185	35	56108842
Rhabdomyolysis	13.34	9.36	196	182994	40462	56068415
Multiple injuries	13.28	9.36	22	183168	1744	56107133
Immunodeficiency	13.25	9.36	20	183170	16137	56092740
Gastrointestinal perforation	13.24	9.36	31	183159	3168	56105709
General physical health deterioration	13.21	9.36	437	182753	169573	55939304
Maternal exposure before pregnancy	13.20	9.36	3	183187	6820	56102057
Ill-defined disorder	13.16	9.36	151	183039	68392	56040485
Eosinophilic pneumonia chronic	13.14	9.36	8	183182	181	56108696
Hepatitis acute	13.13	9.36	58	183132	8299	56100578
Bile duct stone	13.09	9.36	32	183158	3362	56105515
Cystitis noninfective	13.07	9.36	16	183174	958	56107919
Device issue	13.03	9.36	31	183159	21075	56087802
Femoral neck fracture	13.02	9.36	55	183135	7716	56101161
Lung disorder	12.99	9.36	242	182948	52355	56056522
Oesophageal food impaction	12.99	9.36	8	183182	185	56108692
Chronic gastritis	12.95	9.36	27	183163	2551	56106326
Hypoxic-ischaemic encephalopathy	12.94	9.36	35	183155	3910	56104967
Hyperlipidaemia	12.89	9.36	102	183088	18007	56090870
Gastrointestinal disorder	12.89	9.36	274	182916	112428	55996449
Inadequate diet	12.87	9.36	7	183183	127	56108750
Oesophageal achalasia	12.86	9.36	11	183179	429	56108448
Hepatic failure	12.85	9.36	166	183024	33320	56075557
Oropharyngeal swelling	12.83	9.36	15	183175	856	56108021
Urinary straining	12.80	9.36	5	183185	40	56108837
Tongue discolouration	12.73	9.36	29	183161	2910	56105967
Pancreatic carcinoma recurrent	12.67	9.36	6	183184	80	56108797
Injection site mass	12.63	9.36	22	183168	16771	56092106
Unevaluable event	12.61	9.36	97	183093	47590	56061287
Discoloured vomit	12.55	9.36	14	183176	759	56108118
Skin necrosis	12.54	9.36	13	183177	12348	56096529
Vulval haemorrhage	12.54	9.36	4	183186	16	56108861
Finger deformity	12.51	9.36	3	183187	6574	56102303
Joint dislocation	12.48	9.36	20	183170	15753	56093124
Pre-eclampsia	12.46	9.36	6	183184	8480	56100397
Abortion induced	12.45	9.36	8	183182	9637	56099240
Wrong patient received product	12.42	9.36	24	183166	2147	56106730
Illness	12.32	9.36	64	183126	34447	56074430
Occult blood positive	12.29	9.36	31	183159	3320	56105557
Dilatation atrial	12.25	9.36	22	183168	1861	56107016
Stevens-Johnson syndrome	12.17	9.36	120	183070	22543	56086334
Morbid thoughts	12.15	9.36	12	183178	564	56108313
Blood parathyroid hormone decreased	12.15	9.36	6	183184	8358	56100519
Obstructive nephropathy	12.12	9.36	3	183187	3	56108874
Respiratory tract congestion	12.12	9.36	20	183170	15571	56093306
Complication of device insertion	12.08	9.36	3	183187	6421	56102456
Injection site rash	12.06	9.36	23	183167	16935	56091942
Gingival bleeding	12.05	9.36	72	183118	11594	56097283
Rash papulosquamous	11.99	9.36	6	183184	91	56108786
Subdural haematoma	11.89	9.36	80	183110	13419	56095458
Hypoproteinaemia	11.88	9.36	22	183168	1906	56106971
Bone erosion	11.84	9.36	19	183171	14955	56093922
Physical deconditioning	11.79	9.36	12	183178	585	56108292
Muscle spasticity	11.78	9.36	30	183160	19930	56088947
Photodermatosis	11.74	9.36	10	183180	388	56108489
Autonomic neuropathy	11.71	9.36	16	183174	1069	56107808
Nocturia	11.68	9.36	50	183140	7056	56101821
Degenerative mitral valve disease	11.66	9.36	4	183186	21	56108856
Anxiety disorder	11.65	9.36	33	183157	3787	56105090
Presyncope	11.64	9.36	131	183059	25451	56083426
Gamma-glutamyltransferase increased	11.60	9.36	153	183037	30852	56078025
Cold sweat	11.60	9.36	68	183122	10875	56098002
Drug tolerance decreased	11.59	9.36	16	183174	13395	56095482
Blood albumin decreased	11.55	9.36	80	183110	13548	56095329
Limb discomfort	11.52	9.36	46	183144	26576	56082301
Bone pain	11.51	9.36	106	183084	50079	56058798
Rectocele	11.50	9.36	15	183175	958	56107919
Lip blister	11.50	9.36	23	183167	2110	56106767
Seasonal allergy	11.48	9.36	24	183166	17084	56091793
Breast cancer female	11.40	9.36	14	183176	12324	56096553
Hiccups	11.40	9.36	22	183168	1966	56106911
Device malfunction	11.37	9.36	22	183168	16114	56092763
Single functional kidney	11.36	9.36	7	183183	162	56108715
Pharyngotonsillitis	11.36	9.36	7	183183	162	56108715
Blood electrolytes abnormal	11.34	9.36	15	183175	971	56107906
Bradyarrhythmia	11.34	9.36	22	183168	1974	56106903
Pneumonia aspiration	11.33	9.36	158	183032	32253	56076624
Renal cyst haemorrhage	11.33	9.36	5	183185	56	56108821
Splenic vein thrombosis	11.33	9.36	9	183181	316	56108561
Cardiomegaly	11.32	9.36	92	183098	16375	56092502
Tetany	11.30	9.36	20	183170	1672	56107205
Gambling	11.30	9.36	8	183182	235	56108642
Bleeding time prolonged	11.30	9.36	12	183178	615	56108262
Erythema	11.28	9.36	618	182572	155321	55953556
Enterocolitis haemorrhagic	11.28	9.36	18	183172	1383	56107494
Cytomegalovirus test positive	11.28	9.36	27	183163	2799	56106078
Post cardiac arrest syndrome	11.22	9.36	4	183186	24	56108853
Hypoglycaemia	11.19	9.36	249	182941	55566	56053311
Infusion site vesicles	11.17	9.36	10	183180	415	56108462
Atypical femur fracture	11.15	9.36	39	183151	5008	56103869
Gallbladder hypofunction	11.14	9.36	11	183179	517	56108360
Laboratory test abnormal	11.12	9.36	42	183148	24653	56084224
Apraxia	11.08	9.36	20	183170	1699	56107178
Aortic aneurysm rupture	11.05	9.36	11	183179	522	56108355
Hyperphosphataemia	11.04	9.36	22	183168	2013	56106864
Osteonecrosis of jaw	11.02	9.36	161	183029	33197	56075680
Metastases to bone	11	9.36	30	183160	19478	56089399
Impaired quality of life	10.98	9.36	7	183183	8467	56100410
Bronchogenic cyst	10.92	9.36	3	183187	6	56108871
Oligohydramnios	10.89	9.36	3	183187	5991	56102886
Blood cholinesterase decreased	10.88	9.36	6	183184	112	56108765
Adrenal suppression	10.83	9.36	14	183176	886	56107991
Staphylococcus test positive	10.81	9.36	31	183159	3582	56105295
Hyperhidrosis	10.81	9.36	391	182799	93697	56015180
Uraemic encephalopathy	10.79	9.36	8	183182	253	56108624
Chronic kidney disease-mineral and bone disorder	10.79	9.36	8	183182	253	56108624
Regurgitation	10.78	9.36	18	183172	1436	56107441
Haematotoxicity	10.76	9.36	7	183183	8376	56100501
Duodenal ulcer	10.74	9.36	49	183141	7106	56101771
Prothrombin time ratio increased	10.69	9.36	6	183184	116	56108761
Abnormal faeces	10.67	9.36	37	183153	4731	56104146
Fasciitis	10.66	9.36	11	183179	545	56108332
Optic neuritis	10.66	9.36	52	183138	7752	56101125
Ejection fraction decreased	10.63	9.36	105	183085	19736	56089141
Hypercapnic coma	10.61	9.36	7	183183	183	56108694
Heparin-induced thrombocytopenia	10.59	9.36	34	183156	4180	56104697
Loss of consciousness	10.58	9.36	446	182744	108903	55999974
Renal hypertrophy	10.58	9.36	4	183186	29	56108848
Acute myocardial infarction	10.56	9.36	148	183042	30245	56078632
Product complaint	10.54	9.36	70	183120	11690	56097187
Abdominal rigidity	10.54	9.36	20	183170	1765	56107112
Medication error	10.53	9.36	195	182995	42140	56066737
Macroglossia	10.46	9.36	12	183178	671	56108206
Blood uric acid increased	10.45	9.36	34	183156	4208	56104669
Nasal mucosal erosion	10.41	9.36	5	183185	69	56108808
Gastrointestinal amyloidosis	10.34	9.36	5	183185	70	56108807
Protein-losing gastroenteropathy	10.34	9.36	7	183183	191	56108686
Nephrectomy	10.34	9.36	16	183174	1197	56107680
Bradykinesia	10.29	9.36	37	183153	4817	56104060
Flat affect	10.29	9.36	17	183173	1345	56107532
Blood pressure fluctuation	10.26	9.36	83	183107	40277	56068600
Osteoporosis	10.25	9.36	114	183076	51938	56056939
Femoral hernia	10.24	9.36	4	183186	32	56108845
Hyperuricaemia	10.19	9.36	38	183152	5035	56103842
Mouth ulceration	10.17	9.36	144	183046	29496	56079381
Blood creatinine increased	10.15	9.36	337	182853	79854	56029023
Pharyngeal oedema	10.11	9.36	76	183114	13209	56095668
Small intestinal haemorrhage	10.06	9.36	21	183169	1986	56106891
Herpes zoster	10.05	9.36	180	183010	75709	56033168
Arthritis	9.95	9.36	248	182942	99604	56009273
Cerebral mass effect	9.94	9.36	13	183177	832	56108045
Depressed mood	9.94	9.36	170	183020	36189	56072688
Ventricular dysfunction	9.94	9.36	25	183165	2674	56106203
Coagulation test abnormal	9.92	9.36	12	183178	710	56108167
Ventricular hypertrophy	9.90	9.36	28	183162	3210	56105667
Haemorrhoids	9.90	9.36	105	183085	20101	56088776
Disability	9.88	9.36	23	183167	15757	56093120
Chorea	9.84	9.36	17	183173	1395	56107482
Balance disorder	9.80	9.36	322	182868	76198	56032679
Glycosuria	9.75	9.36	15	183175	1117	56107760
Rash maculo-papular	9.74	9.36	140	183050	28767	56080110
Loose tooth	9.69	9.36	28	183162	3250	56105627
Gastrointestinal stoma output increased	9.68	9.36	7	183183	213	56108664
Fanconi syndrome	9.67	9.36	16	183174	1267	56107610
Scleroderma	9.66	9.36	37	183153	4964	56103913
Gingival erosion	9.65	9.36	7	183183	214	56108663
Gingival hypertrophy	9.59	9.36	17	183173	1423	56107454
Drug eruption	9.59	9.36	127	183063	25636	56083241
Arteriosclerosis	9.55	9.36	58	183132	9395	56099482
Post cholecystectomy syndrome	9.53	9.36	5	183185	84	56108793
Infusion site pain	9.50	9.36	19	183171	13743	56095134
Adverse event	9.49	9.36	125	183065	55251	56053626
Joint injury	9.49	9.36	47	183143	25607	56083270
Transplant rejection	9.47	9.36	11	183179	9923	56098954
Wheelchair user	9.45	9.36	3	183187	5463	56103414
Hepatitis	9.43	9.36	165	183025	35276	56073601
Muscle tension dysphonia	9.43	9.36	5	183185	86	56108791
Pulmonary venous thrombosis	9.40	9.36	3	183187	12	56108865
Documented hypersensitivity to administered product	9.39	9.36	10	183180	514	56108363
Renal hypertension	9.36	9.36	6	183184	149	56108728

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Chronic kidney disease	593.71	10.08	739	123860	37236	31535509
Drug ineffective	336.95	10.08	655	123944	394918	31177827
Death	268.56	10.08	643	123956	359926	31212819
End stage renal disease	262.52	10.08	233	124366	7876	31564869
Completed suicide	241.29	10.08	36	124563	91478	31481267
Hyponatraemia	191.70	10.08	682	123917	73117	31499628
Colitis microscopic	177.16	10.08	106	124493	1904	31570841
Renal injury	175.26	10.08	213	124386	10452	31562293
Interstitial lung disease	171.20	10.08	581	124018	60822	31511923
Toxicity to various agents	136.67	10.08	321	124278	181166	31391579
Product dose omission issue	127.62	10.08	136	124463	105450	31467295
Drug dispensed to wrong patient	122.45	10.08	52	124547	427	31572318
Off label use	120.30	10.08	836	123763	346438	31226307
Drug abuse	120.15	10.08	101	124498	87657	31485088
Acute kidney injury	116.01	10.08	1639	122960	278075	31294670
Appendicolith	93.41	10.08	114	124485	5617	31567128
Fatigue	91.56	10.08	860	123739	334346	31238399
Cerebral infarction	88.04	10.08	263	124336	25714	31547031
Treatment failure	87.12	10.08	26	124573	40766	31531979
Nephrogenic anaemia	83.58	10.08	68	124531	2035	31570710
Foetal exposure during pregnancy	80.40	10.08	30	124569	40846	31531899
Neutropenic sepsis	76.79	10.08	158	124441	12221	31560524
Hepatic function abnormal	74.14	10.08	340	124259	40882	31531863
Lower respiratory tract infection	74.11	10.08	262	124337	27975	31544770
Hypertensive nephropathy	73.42	10.08	36	124563	425	31572320
Hypomagnesaemia	69.42	10.08	198	124401	18860	31553885
Product use in unapproved indication	66.36	10.08	186	124413	98985	31473760
Venous pressure jugular increased	66.05	10.08	40	124559	735	31572010
Drug resistance	64.66	10.08	8	124591	23445	31549300
Appendicitis	63.79	10.08	140	124459	11325	31561420
Gastrooesophageal reflux disease	62.87	10.08	282	124317	33589	31539156
Intentional product use issue	59.08	10.08	64	124535	49283	31523462
Renal impairment	57.02	10.08	554	124045	85795	31486950
COVID-19	56.30	10.08	80	124519	54741	31518004
Intentional overdose	56.16	10.08	48	124551	41341	31531404
Hypoparathyroidism secondary	52.98	10.08	20	124579	116	31572629
Wrong patient received product	51.94	10.08	57	124542	2502	31570243
Liver function test abnormal	51.24	10.08	242	124357	29450	31543295
Suicide attempt	50.78	10.08	43	124556	37205	31535540
Antimicrobial susceptibility test resistant	47.61	10.08	24	124575	302	31572443
Rheumatoid arthritis	46.91	10.08	72	124527	47737	31525008
Toxic epidermal necrolysis	46.86	10.08	176	124423	19348	31553397
Cholestasis	46.70	10.08	209	124390	24866	31547879
Nephropathy	46.53	10.08	80	124519	5399	31567346
Malaise	45.56	10.08	922	123677	167589	31405156
Diabetic nephropathy	44.50	10.08	47	124552	1974	31570771
Hypergastrinaemia	44.44	10.08	15	124584	59	31572686
Subacute cutaneous lupus erythematosus	41.27	10.08	32	124567	892	31571853
Minimum inhibitory concentration	40.60	10.08	16	124583	106	31572639
Full blood count abnormal	39.60	10.08	8	124591	16339	31556406
Neutrophil count decreased	39.05	10.08	314	124285	46080	31526665
Drug intolerance	37.51	10.08	94	124505	51939	31520806
Melaena	37.36	10.08	238	124361	32416	31540329
Haematemesis	37.15	10.08	199	124400	25454	31547291
Therapeutic response delayed	36.78	10.08	24	124575	505	31572240
Tetany	36.10	10.08	26	124573	646	31572099
Hypocalcaemia	35.66	10.08	176	124423	21802	31550943
Occupational dermatitis	35.39	10.08	13	124586	69	31572676
Chronic kidney disease-mineral and bone disorder	35.30	10.08	21	124578	373	31572372
Hepatocellular injury	35.30	10.08	173	124426	21371	31551374
Inappropriate schedule of product administration	34.96	10.08	94	124505	50729	31522016
Tetanus	34.45	10.08	12	124587	53	31572692
Hospitalisation	34.35	10.08	92	124507	49715	31523030
Tubulointerstitial nephritis	34.31	10.08	154	124445	18342	31554403
Abdominal pain	34.09	10.08	782	123817	145170	31427575
Device dependence	33.91	10.08	11	124588	37	31572708
Peripheral swelling	33.43	10.08	145	124454	67720	31505025
Disease progression	32.00	10.08	216	124383	90248	31482497
Weight increased	31.92	10.08	193	124406	82754	31489991
Jaundice	31.76	10.08	216	124383	30071	31542674
Therapeutic product effect incomplete	31.44	10.08	79	124520	43617	31529128
Rash vesicular	31.42	10.08	44	124555	2483	31570262
Pain	30.97	10.08	532	124067	186227	31386518
Abdominal distension	30.92	10.08	320	124279	50364	31522381
Gastric cancer	30.49	10.08	71	124528	5974	31566771
Drug eruption	30.48	10.08	147	124452	18040	31554705
Hyperchlorhydria	30.41	10.08	23	124576	617	31572128
Drug hypersensitivity	30.04	10.08	165	124434	72434	31500311
Agranulocytosis	29.54	10.08	163	124436	21084	31551661
Liver disorder	28.88	10.08	208	124391	29499	31543246
Overdose	28.54	10.08	205	124394	84459	31488286
Ventricular fibrillation	28.52	10.08	148	124451	18700	31554045
Stress	28.04	10.08	181	124418	24760	31547985
Poisoning	27.56	10.08	4	124595	10387	31562358
Nasopharyngitis	27.13	10.08	142	124457	63103	31509642
Haemorrhage subcutaneous	27.06	10.08	38	124561	2150	31570595
Injection site pain	27.00	10.08	60	124539	34574	31538171
Adverse drug reaction	26.64	10.08	36	124563	25165	31547580
Blood pressure fluctuation	26.64	10.08	30	124569	22706	31550039
Therapeutic product effect decreased	26.15	10.08	53	124546	31569	31541176
Ascites	25.52	10.08	260	124339	40753	31531992
Pancreatitis acute	25.33	10.08	180	124419	25420	31547325
Hepatic cytolysis	24.68	10.08	96	124503	10727	31562018
Loss of personal independence in daily activities	24.61	10.08	46	124553	28242	31544503
Renal failure	24.35	10.08	646	123953	122684	31450061
Platelet count decreased	24.32	10.08	587	124012	109848	31462897
Unevaluable event	23.81	10.08	53	124546	30522	31542223
Disseminated intravascular coagulation	23.68	10.08	150	124449	20387	31552358
Melanoderma	23.66	10.08	12	124587	153	31572592
Enteritis infectious	23.47	10.08	27	124572	1249	31571496
Neutrophil count increased	23.44	10.08	123	124476	15608	31557137
Lip swelling	23.28	10.08	109	124490	13214	31559531
Cystitis escherichia	23.26	10.08	12	124587	159	31572586
Pneumonia bacterial	23.21	10.08	91	124508	10205	31562540
Dissociation	22.86	10.08	27	124572	1285	31571460
Intentional product misuse	22.63	10.08	75	124524	37876	31534869
Synovitis	22.54	10.08	10	124589	12273	31560472
Protein-losing gastroenteropathy	22.41	10.08	15	124584	330	31572415
Vomiting	22.29	10.08	1085	123514	222888	31349857
Adrenal suppression	22.17	10.08	18	124581	537	31572208
Pulmonary fibrosis	21.96	10.08	126	124473	16534	31556211
Occupational exposure to air contaminants	21.85	10.08	11	124588	138	31572607
Gastric polyps	21.78	10.08	24	124575	1058	31571687
Pneumonia aspiration	21.52	10.08	240	124359	38486	31534259
Hiatus hernia	21.35	10.08	68	124531	6879	31565866
Orthostatic hypotension	21.25	10.08	165	124434	23954	31548791
Neurotoxicity	20.60	10.08	20	124579	16206	31556539
Gait disturbance	20.52	10.08	200	124399	77295	31495450
Confusional state	20.49	10.08	677	123922	132657	31440088
Accidental exposure to product	20.11	10.08	10	124589	11485	31561260
Hepatitis acute	20.01	10.08	65	124534	6644	31566101
Dry skin	19.98	10.08	44	124555	25437	31547308
Toxic skin eruption	19.82	10.08	86	124513	10094	31562651
Rectal haemorrhage	19.72	10.08	224	124375	36080	31536665
Blood alkaline phosphatase increased	19.42	10.08	189	124410	29264	31543481
Renal disorder	19.33	10.08	159	124440	23486	31549259
Prostatic specific antigen increased	19.23	10.08	15	124584	13523	31559222
Gastric varices	19.22	10.08	15	124584	422	31572323
Gingival disorder	19.00	10.08	25	124574	1329	31571416
Weight decreased	19.00	10.08	481	124118	159471	31413274
Rebound acid hypersecretion	18.99	10.08	9	124590	98	31572647
Marasmus	18.91	10.08	16	124583	506	31572239
Hypozincaemia	18.80	10.08	5	124594	6	31572739
Sinobronchitis	18.80	10.08	5	124594	6	31572739
Femoral neck fracture	18.79	10.08	38	124561	2902	31569843
Enterochromaffin cell hyperplasia	18.77	10.08	6	124593	19	31572726
Biliary sepsis	18.72	10.08	17	124582	592	31572153
Renal cyst	18.66	10.08	74	124525	8342	31564403
Contraindication to medical treatment	18.60	10.08	17	124582	597	31572148
Hypoacusis	18.45	10.08	19	124580	14980	31557765
Sopor	18.38	10.08	92	124507	11460	31561285
Haematotoxicity	18.35	10.08	3	124596	7134	31565611
Cholangitis	18.34	10.08	71	124528	7915	31564830
Immune thrombocytopenia	18.27	10.08	74	124525	8424	31564321
Vasculitic rash	18.18	10.08	20	124579	880	31571865
Failure to anastomose	18.07	10.08	11	124588	204	31572541
Dialysis	17.98	10.08	86	124513	10517	31562228
Glomerulosclerosis	17.92	10.08	18	124581	712	31572033
Alcoholic liver disease	17.89	10.08	16	124583	546	31572199
Nephrosclerosis	17.81	10.08	20	124579	901	31571844
Pathogen resistance	17.76	10.08	6	124593	8695	31564050
Drug dependence	17.70	10.08	39	124560	22540	31550205
Joint swelling	17.69	10.08	130	124469	53301	31519444
Psoriatic arthropathy	17.59	10.08	32	124567	19851	31552894
Upper respiratory tract inflammation	17.55	10.08	27	124572	1659	31571086
Cardio-respiratory arrest	17.54	10.08	125	124474	51601	31521144
White blood cell count increased	17.45	10.08	232	124367	38768	31533977
Subdural haematoma	17.39	10.08	131	124468	18840	31553905
Psoriasis	17.29	10.08	110	124489	46609	31526136
Idiopathic pulmonary fibrosis	17.12	10.08	45	124554	4085	31568660
Renal hypertension	17.09	10.08	10	124589	172	31572573
Oesophagitis	17.09	10.08	95	124504	12321	31560424
Paraesthesia oral	17.03	10.08	42	124557	3666	31569079
Mouth ulceration	16.98	10.08	86	124513	10762	31561983
Therapy non-responder	16.79	10.08	72	124527	33739	31539006
Transient ischaemic attack	16.67	10.08	156	124443	23900	31548845
Respiratory muscle weakness	16.65	10.08	8	124591	90	31572655
Renal artery stenosis	16.54	10.08	30	124569	2112	31570633
Barrett's oesophagus	16.49	10.08	14	124585	445	31572300
Blood albumin decreased	16.37	10.08	94	124505	12337	31560408
Therapy partial responder	16.34	10.08	3	124596	6559	31566186
Hyperuricaemia	16.17	10.08	65	124534	7373	31565372
Aspergillus infection	16.09	10.08	13	124586	11515	31561230
Immune reconstitution inflammatory syndrome	16.08	10.08	6	124593	8172	31564573
Faecal vomiting	16.03	10.08	13	124586	387	31572358
Laboratory test abnormal	16.01	10.08	31	124568	18783	31553962
Wrong technique in product usage process	15.95	10.08	72	124527	33271	31539474
Aplastic anaemia	15.86	10.08	75	124524	9128	31563617
Hypotension	15.74	10.08	651	123948	203967	31368778
Periprosthetic fracture	15.68	10.08	9	124590	149	31572596
Dermatitis acneiform	15.54	10.08	54	124545	5713	31567032
Constipation	15.48	10.08	615	123984	123376	31449369
Blood magnesium decreased	15.44	10.08	54	124545	5732	31567013
Therapy cessation	15.42	10.08	22	124577	15033	31557712
Duodenal polyp	15.26	10.08	10	124589	212	31572533
Asthenia	15.25	10.08	725	123874	224030	31348715
Gastrointestinal ulcer	15.05	10.08	25	124574	1640	31571105
Haemorrhagic cerebral infarction	15.04	10.08	17	124582	771	31571974
Follicular mucinosis	14.95	10.08	5	124594	19	31572726
Device malfunction	14.85	10.08	9	124590	9257	31563488
Blood phosphorus increased	14.82	10.08	45	124554	4437	31568308
Electrocardiogram ST-T segment abnormal	14.78	10.08	10	124589	224	31572521
Renal haemangioma	14.75	10.08	5	124594	20	31572725
Gastrointestinal tract irritation	14.67	10.08	10	124589	227	31572518
Haemoptysis	14.61	10.08	192	124407	31997	31540748
Enterocolitis	14.58	10.08	62	124537	7212	31565533
Thrombosis	14.40	10.08	111	124488	45040	31527705
Cardiogenic shock	14.39	10.08	143	124456	22265	31550480
Underdose	14.37	10.08	17	124582	12590	31560155
Gastrointestinal motility disorder	14.35	10.08	30	124569	2346	31570399
Macroglossia	14.25	10.08	12	124587	377	31572368
Coma	14.17	10.08	99	124500	41051	31531694
Infusion related reaction	14.02	10.08	121	124478	47934	31524811
Retinal vascular occlusion	13.94	10.08	9	124590	186	31572559
Dyspepsia	13.89	10.08	192	124407	32361	31540384
Ischaemic nephropathy	13.85	10.08	5	124594	25	31572720
Wrong product administered	13.81	10.08	47	124552	4921	31567824
Eosinophil count increased	13.80	10.08	64	124535	7727	31565018
Inhibitory drug interaction	13.73	10.08	23	124576	1519	31571226
Faeces discoloured	13.67	10.08	97	124502	13689	31559056
Pulmonary thrombosis	13.62	10.08	5	124594	6880	31565865
Drug reaction with eosinophilia and systemic symptoms	13.61	10.08	179	124420	29839	31542906
Drug-induced liver injury	13.54	10.08	151	124448	24212	31548533
Therapy interrupted	13.52	10.08	13	124586	10583	31562162
Thrombotic cerebral infarction	13.41	10.08	11	124588	333	31572412
Hyponatraemic seizure	13.37	10.08	6	124593	57	31572688
Gastritis	13.27	10.08	130	124469	20162	31552583
Lymphocyte stimulation test positive	13.16	10.08	15	124584	687	31572058
Localised infection	13.12	10.08	25	124574	15240	31557505
Neuroendocrine tumour	13.10	10.08	16	124583	789	31571956
Gastric ulcer haemorrhage	12.98	10.08	47	124552	5076	31567669
Nocturia	12.93	10.08	71	124528	9164	31563581
Burning feet syndrome	12.92	10.08	7	124592	103	31572642
Hepatic encephalopathy	12.87	10.08	95	124504	13576	31559169
Eosinophilia	12.87	10.08	144	124455	23109	31549636
Cytokine release syndrome	12.83	10.08	29	124570	16613	31556132
Clostridium test positive	12.81	10.08	29	124570	2395	31570350
Product use issue	12.80	10.08	152	124447	56607	31516138
Peptic ulcer	12.71	10.08	30	124569	2546	31570199
Circulatory collapse	12.68	10.08	126	124473	19618	31553127
Oesophagogastric fundoplasty	12.67	10.08	4	124595	12	31572733
Radiation pneumonitis	12.65	10.08	29	124570	2415	31570330
Erythema multiforme	12.64	10.08	64	124535	8007	31564738
Cerebral haemorrhage	12.59	10.08	190	124409	32622	31540123
Embolic cerebral infarction	12.53	10.08	14	124585	627	31572118
Procedural failure	12.53	10.08	6	124593	67	31572678
Central nervous system mass	12.46	10.08	7	124592	111	31572634
Pelvic cyst	12.46	10.08	5	124594	35	31572710
Wall motion score index abnormal	12.41	10.08	7	124592	112	31572633
Neuropathy peripheral	12.34	10.08	216	124383	75433	31497312
Incorrect dose administered	12.31	10.08	86	124513	35666	31537079
Sterile pyuria	12.22	10.08	5	124594	37	31572708
Henoch-Schonlein purpura	12.19	10.08	22	124577	1543	31571202
Granulomatous dermatitis	12.18	10.08	9	124590	233	31572512
Drug ineffective for unapproved indication	12.15	10.08	33	124566	17757	31554988
N-telopeptide urine increased	12.11	10.08	5	124594	38	31572707
Chondrocalcinosis	12.07	10.08	10	124589	307	31572438
Oculocephalogyric reflex absent	12.00	10.08	4	124595	15	31572730
Poisoning deliberate	11.95	10.08	7	124592	7337	31565408
Multiple sclerosis relapse	11.95	10.08	18	124581	12029	31560716
Gastric varices haemorrhage	11.95	10.08	9	124590	240	31572505
Lymphocyte count decreased	11.94	10.08	129	124470	20520	31552225
Hypersensitivity vasculitis	11.90	10.08	34	124565	3241	31569504
Brain stem haemorrhage	11.88	10.08	16	124583	870	31571875
Intracranial haematoma	11.85	10.08	11	124588	394	31572351
Spinal cord haemorrhage	11.83	10.08	10	124589	316	31572429
Inappropriate antidiuretic hormone secretion	11.81	10.08	81	124518	11306	31561439
Dehydration	11.81	10.08	577	124022	118534	31454211
Diffuse vasculitis	11.80	10.08	6	124593	77	31572668
Generalised onset non-motor seizure	11.80	10.08	4	124595	16	31572729
Enterocolitis haemorrhagic	11.77	10.08	16	124583	878	31571867
Putamen haemorrhage	11.76	10.08	9	124590	246	31572499
Prostate cancer	11.73	10.08	93	124506	37508	31535237
Hirsutism	11.72	10.08	8	124591	182	31572563
Carotid bruit	11.68	10.08	8	124591	183	31572562
Sedation	11.64	10.08	37	124562	18928	31553817
Metaplasia	11.63	10.08	9	124590	250	31572495
Exposed bone in jaw	11.60	10.08	21	124578	1476	31571269
Mobility decreased	11.59	10.08	62	124537	27407	31545338
Gastric pH increased	11.56	10.08	3	124596	3	31572742
Discharge	11.54	10.08	9	124590	253	31572492
Cerebral hyperperfusion syndrome	11.53	10.08	6	124593	81	31572664
Osteonecrosis of jaw	11.48	10.08	110	124489	16961	31555784
Influenza	11.47	10.08	115	124484	44210	31528535
Blood creatine phosphokinase increased	11.41	10.08	230	124369	41744	31531001
Mesothelioma	11.40	10.08	11	124588	414	31572331
Meniere's disease	11.38	10.08	5	124594	45	31572700
Device issue	11.31	10.08	10	124589	8474	31564271
Ventricular hypertrophy	11.28	10.08	40	124559	4276	31568469
Product dispensing error	11.27	10.08	49	124550	5755	31566990
Premature baby	11.26	10.08	35	124564	18031	31554714
Iron deficiency anaemia	11.19	10.08	69	124530	9290	31563455
Neuropathic ulcer	11.08	10.08	4	124595	20	31572725
Full blood count decreased	11.06	10.08	31	124568	16509	31556236
Chest pain	11.06	10.08	564	124035	116393	31456352
Plasma cell myeloma	11.04	10.08	156	124443	56375	31516370
Aortic dissection	10.99	10.08	28	124571	2494	31570251
Gastrostomy tube site complication	10.92	10.08	5	124594	50	31572695
Cerebellar infarction	10.85	10.08	23	124576	1816	31570929
Rhabdomyolysis	10.85	10.08	327	124272	63254	31509491
Upper gastrointestinal haemorrhage	10.82	10.08	139	124460	23044	31549701
Occupational exposure to product	10.80	10.08	10	124589	357	31572388
Muscle injury	10.77	10.08	19	124580	1309	31571436
Coronary artery disease	10.75	10.08	247	124352	45840	31526905
Hyperkalaemia	10.72	10.08	330	124269	64021	31508724
Sexually inappropriate behaviour	10.69	10.08	11	124588	448	31572297
Alanine aminotransferase increased	10.68	10.08	376	124223	74280	31498465
Respiratory depression	10.62	10.08	26	124573	14484	31558261
Electrocardiogram QT prolonged	10.61	10.08	209	124390	37778	31534967
Rash morbilliform	10.56	10.08	29	124570	2702	31570043
Myocardial ischaemia	10.52	10.08	106	124493	16561	31556184
Therapeutic response unexpected	10.47	10.08	12	124587	9012	31563733
Amaurosis fugax	10.43	10.08	12	124587	555	31572190
Ammonia decreased	10.36	10.08	3	124596	6	31572739
Dressler's syndrome	10.35	10.08	4	124595	25	31572720
Hip fracture	10.34	10.08	17	124582	10969	31561776
Renal infarct	10.26	10.08	18	124581	1234	31571511
Urinary retention	10.26	10.08	188	124411	33537	31539208
Cirrhosis alcoholic	10.23	10.08	14	124585	773	31571972
Transverse sinus thrombosis	10.21	10.08	4	124595	26	31572719
Renal atrophy	10.20	10.08	17	124582	1118	31571627
Helicobacter test positive	10.18	10.08	14	124585	777	31571968
Cardiac murmur	10.16	10.08	53	124546	6709	31566036
Lichenoid keratosis	10.16	10.08	26	124573	2322	31570423
Haematuria	10.12	10.08	246	124353	46068	31526677
Airway remodelling	10.11	10.08	7	124592	163	31572582

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	787.09	9.46	1434	261776	938318	69726916
Chronic kidney disease	600.89	9.46	923	262287	60134	70605100
Completed suicide	582.74	9.46	77	263133	227058	70438176
Hyponatraemia	539.04	9.46	1557	261653	158530	70506704
Colitis microscopic	487.00	9.46	342	262868	8663	70656571
Death	328.60	9.46	896	262314	509165	70156069
Acute kidney injury	274.11	9.46	2827	260383	471797	70193437
Toxicity to various agents	265.37	9.46	646	262564	381526	70283708
End stage renal disease	257.83	9.46	259	262951	10874	70654360
Rheumatoid arthritis	248.30	9.46	439	262771	291366	70373868
Hypomagnesaemia	242.12	9.46	494	262716	40270	70624964
Interstitial lung disease	235.92	9.46	889	262321	103796	70561438
Product dose omission issue	220.72	9.46	290	262920	217178	70448056
Off label use	219.23	9.46	1738	261472	741322	69923912
Fatigue	188.43	9.46	2055	261155	822264	69842970
Subacute cutaneous lupus erythematosus	187.76	9.46	128	263082	3085	70662149
Drug intolerance	183.46	9.46	349	262861	225338	70439896
Drug abuse	180.57	9.46	168	263042	147088	70518146
Therapeutic product effect incomplete	174.50	9.46	115	263095	119767	70545467
Neutropenic sepsis	171.88	9.46	321	262889	24509	70640725
Cerebral infarction	164.94	9.46	439	262771	42570	70622664
Treatment failure	160.19	9.46	179	263031	143963	70521271
Synovitis	154.27	9.46	151	263059	129077	70536157
Pain	151.78	9.46	1547	261663	627269	70037965
Hepatic function abnormal	149.47	9.46	573	262637	67423	70597811
Renal injury	143.97	9.46	233	262977	15861	70649373
Gastrooesophageal reflux disease	126.85	9.46	669	262541	90170	70575064
Injection site pain	124.29	9.46	152	263058	117467	70547767
Haematemesis	112.86	9.46	418	262792	48379	70616855
Nephrogenic anaemia	112.23	9.46	99	263111	3519	70661715
Melaena	110.28	9.46	458	262752	55897	70609337
Therapeutic product effect decreased	107.75	9.46	231	262979	142787	70522447
Joint swelling	107.63	9.46	528	262682	252683	70412551
Contraindicated product administered	104.28	9.46	214	262996	134398	70530836
Loss of personal independence in daily activities	103.90	9.46	97	263113	84813	70580421
Hypertensive nephropathy	101.12	9.46	54	263156	820	70664414
Appendicolith	97.84	9.46	113	263097	5567	70659667
Arthropathy	97.48	9.46	262	262948	149795	70515439
Hypocalcaemia	96.91	9.46	376	262834	44483	70620751
Cholestasis	95.19	9.46	391	262819	47481	70617753
Liver function test abnormal	94.93	9.46	464	262746	60682	70604552
Abdominal pain	92.94	9.46	1784	261426	340343	70324891
Confusional state	91.04	9.46	1522	261688	282876	70382358
COVID-19	90.81	9.46	158	263052	105599	70559635
Renal failure	90.33	9.46	1086	262124	187984	70477250
Intentional overdose	89.21	9.46	142	263068	98293	70566941
Renal impairment	87.80	9.46	868	262342	143069	70522165
Drug resistance	86.61	9.46	18	263192	38172	70627062
Weight increased	83.09	9.46	542	262668	241789	70423445
Drug hypersensitivity	82.60	9.46	602	262608	261857	70403377
Hepatocellular injury	81.27	9.46	363	262847	45728	70619506
Lower respiratory tract infection	80.39	9.46	699	262511	111214	70554020
Drug dispensed to wrong patient	79.18	9.46	40	263170	538	70664696
Alopecia	76.95	9.46	427	262783	198063	70467171
Jaundice	76.18	9.46	378	262832	49730	70615504
Hypokalaemia	75.62	9.46	782	262428	130406	70534828
Electric shock	75.57	9.46	50	263160	1145	70664089
Electrocardiogram QT prolonged	74.93	9.46	549	262661	82968	70582266
Agranulocytosis	73.80	9.46	321	262889	39977	70625257
Product use in unapproved indication	73.70	9.46	459	262751	207019	70458215
Swollen tongue	72.41	9.46	301	262909	36745	70628489
Faeces discoloured	71.76	9.46	241	262969	26568	70638666
Maternal exposure during pregnancy	70.75	9.46	207	263003	115138	70550096
Suicide attempt	69.89	9.46	117	263093	79393	70585841
Neutrophil count decreased	69.19	9.46	539	262671	83017	70582217
Arthralgia	69.11	9.46	1385	261825	502005	70163229
Hypergastrinaemia	68.64	9.46	26	263184	163	70665071
Appendicitis	68.44	9.46	175	263035	16558	70648676
Cholecystitis chronic	68.39	9.46	124	263086	9252	70655982
Sinusitis	67.76	9.46	360	262850	168835	70496399
Infusion related reaction	67.60	9.46	442	262768	197092	70468142
Peripheral swelling	65.86	9.46	561	262649	236002	70429232
Intentional product use issue	65.70	9.46	227	262983	119915	70545319
Hand deformity	64.85	9.46	140	263070	86342	70578892
Tubulointerstitial nephritis	63.28	9.46	267	262943	32809	70632425
Diabetic nephropathy	63.27	9.46	64	263146	2709	70662525
Inappropriate schedule of product administration	63.11	9.46	197	263013	107358	70557876
Rectal haemorrhage	62.68	9.46	439	262771	65392	70599842
Product use issue	61.88	9.46	402	262808	179535	70485699
Sopor	61.86	9.46	255	262955	31012	70634222
Exposure during pregnancy	61.71	9.46	147	263063	87570	70577664
Device expulsion	60.83	9.46	6	263204	22240	70642994
Lip swelling	60.64	9.46	269	262941	33785	70631449
Vomiting	59.34	9.46	2729	260481	590382	70074852
Nasopharyngitis	58.30	9.46	535	262675	221671	70443563
Psoriasis	57.96	9.46	180	263030	98253	70566981
Pemphigus	56.96	9.46	141	263069	82895	70582339
Platelet count decreased	55.21	9.46	949	262261	177273	70487961
Chest pain	54.13	9.46	1267	261943	249993	70415241
Venous pressure jugular increased	53.37	9.46	42	263168	1270	70663964
Gastritis	53.30	9.46	315	262895	44276	70620958
Hospitalisation	52.22	9.46	146	263064	82422	70582812
Liver disorder	51.99	9.46	399	262811	61169	70604065
Malaise	51.80	9.46	2030	261180	430902	70234332
Nephropathy	51.26	9.46	106	263104	8719	70656515
Systemic lupus erythematosus	50.18	9.46	201	263009	101701	70563533
Infective pulmonary exacerbation of cystic fibrosis	49.57	9.46	127	263083	12031	70653203
Accidental exposure to product	49.49	9.46	21	263189	28030	70637204
Wrong technique in product usage process	49.22	9.46	114	263096	68584	70596650
Injection site pruritus	48.90	9.46	44	263166	39166	70626068
Haemorrhage subcutaneous	48.36	9.46	71	263139	4438	70660796
Antimicrobial susceptibility test resistant	48.02	9.46	24	263186	315	70664919
Pneumonia bacterial	47.58	9.46	153	263057	16488	70648746
Injection site erythema	47.58	9.46	127	263083	72797	70592437
Hypoparathyroidism secondary	46.24	9.46	20	263190	184	70665050
Wrong patient received product	45.83	9.46	69	263141	4411	70660823
Intervertebral discitis	45.32	9.46	66	263144	4095	70661139
Abdominal discomfort	45.23	9.46	544	262666	214114	70451120
Swelling	45.19	9.46	464	262746	188075	70477159
Toxic skin eruption	45.18	9.46	171	263039	19991	70645243
Hepatic enzyme increased	45.16	9.46	369	262841	156621	70508613
Therapy interrupted	44.68	9.46	18	263192	24784	70640450
Swelling face	44.55	9.46	393	262817	62771	70602463
Disseminated intravascular coagulation	44.53	9.46	244	262966	33354	70631880
Injection site reaction	44.14	9.46	73	263137	49779	70615455
Hepatic cytolysis	44.03	9.46	164	263046	19028	70646206
Mobility decreased	43.57	9.46	215	262995	102784	70562450
Circulatory collapse	43.31	9.46	252	262958	35222	70630012
Toxic epidermal necrolysis	43.21	9.46	273	262937	39284	70625950
Anti-cyclic citrullinated peptide antibody positive	42.99	9.46	126	263084	70059	70595175
Labile blood pressure	42.89	9.46	46	263164	2086	70663148
Upper respiratory tract inflammation	42.17	9.46	62	263148	3880	70661354
Minimum inhibitory concentration	41.75	9.46	16	263194	104	70665130
Therapy cessation	41.75	9.46	38	263172	33638	70631596
Device dependence	40.98	9.46	13	263197	43	70665191
Sedation	40.85	9.46	69	263141	46662	70618572
Blood alkaline phosphatase increased	40.69	9.46	363	262847	58158	70607076
Overdose	40.58	9.46	418	262792	169327	70495907
Drug ineffective for unapproved indication	40.48	9.46	50	263160	38488	70626746
International normalised ratio increased	40.41	9.46	468	262742	80258	70584976
Reflux gastritis	40.27	9.46	34	263176	1138	70664096
Brain stem glioma	40.04	9.46	19	263191	221	70665013
Red blood cell sedimentation rate abnormal	40.03	9.46	11	263199	19292	70645942
Coronary artery disease	40.02	9.46	382	262828	62354	70602880
Injection site swelling	39.33	9.46	62	263148	43095	70622139
Hyperkalaemia	39.16	9.46	584	262626	106007	70559227
Tetany	39.09	9.46	45	263165	2209	70663025
Oesophagitis	38.87	9.46	177	263033	22475	70642759
Blood sodium decreased	38.36	9.46	221	262989	30777	70634457
Blood pressure fluctuation	38.32	9.46	103	263107	58909	70606325
Poisoning	38.24	9.46	18	263192	22604	70642630
Pancreatitis acute	37.58	9.46	292	262918	44932	70620302
Drug reaction with eosinophilia and systemic symptoms	37.38	9.46	354	262856	57659	70607575
Nasal congestion	37.32	9.46	122	263088	65550	70599684
Therapeutic response decreased	37.23	9.46	103	263107	58350	70606884
Biliary dyskinesia	36.82	9.46	45	263165	2354	70662880
Urine magnesium decreased	36.80	9.46	8	263202	0	70665234
Cardiac failure	36.69	9.46	742	262468	142799	70522435
Influenza	36.59	9.46	259	262951	113441	70551793
Orthostatic hypotension	36.00	9.46	321	262889	51422	70613812
Enteritis infectious	35.67	9.46	51	263159	3111	70662123
Post-traumatic stress disorder	35.66	9.46	61	263149	4346	70660888
Chronic kidney disease-mineral and bone disorder	35.19	9.46	25	263185	645	70664589
Therapy partial responder	35.09	9.46	3	263207	12471	70652763
Tetanus	34.95	9.46	12	263198	54	70665180
Device dislocation	34.94	9.46	20	263190	22487	70642747
Cerebral haemorrhage	34.86	9.46	329	262881	53535	70611699
Red blood cell sedimentation rate increased	34.76	9.46	56	263154	38586	70626648
Enterochromaffin cell hyperplasia	34.66	9.46	13	263197	79	70665155
Immune thrombocytopenia	33.77	9.46	135	263075	16189	70649045
Angioedema	33.71	9.46	387	262823	66223	70599011
Dehydration	33.56	9.46	1087	262123	225055	70440179
Discomfort	33.52	9.46	241	262969	105195	70560039
Glossodynia	33.51	9.46	186	263024	86301	70578933
Occupational dermatitis	33.43	9.46	14	263196	118	70665116
Hepatic ischaemia	33.37	9.46	29	263181	1010	70664224
Biliary sepsis	33.13	9.46	34	263176	1464	70663770
Anaemia	32.96	9.46	1821	261389	401602	70263632
Decreased appetite	32.92	9.46	1414	261796	303366	70361868
Gastric cancer	32.91	9.46	90	263120	8865	70656369
Cholangitis	32.85	9.46	106	263104	11443	70653791
Lethargy	32.78	9.46	425	262785	74825	70590409
Erythema multiforme	32.69	9.46	135	263075	16429	70648805
Hyperchlorhydria	32.26	9.46	37	263173	1809	70663425
Psoriatic arthropathy	31.73	9.46	128	263082	64643	70600591
Diarrhoea	31.41	9.46	3342	259868	779999	69885235
Poisoning deliberate	31.36	9.46	12	263198	17048	70648186
Gastric polyps	31.24	9.46	50	263160	3371	70661863
Enterocolitis	31.10	9.46	113	263097	12953	70652281
Protein-losing gastroenteropathy	31.05	9.46	22	263188	565	70664669
Eosinophilia	30.60	9.46	255	262955	40064	70625170
Upper gastrointestinal haemorrhage	30.59	9.46	241	262969	37236	70627998
Rheumatoid nodule	30.48	9.46	9	263201	15058	70650176
Facet joint syndrome	30.45	9.46	69	263141	6044	70659190
Hiatus hernia	30.41	9.46	157	263053	20977	70644257
Coma scale abnormal	30.25	9.46	82	263128	8034	70657200
Gastrointestinal motility disorder	30.18	9.46	65	263145	5501	70659733
Injection site bruising	29.82	9.46	60	263150	37972	70627262
Haemoptysis	29.76	9.46	307	262903	51145	70614089
Wound	29.33	9.46	230	262980	98502	70566732
Hepatitis acute	29.31	9.46	116	263094	13846	70651388
Neurotoxicity	28.98	9.46	41	263169	29785	70635449
Dysphagia	28.74	9.46	583	262627	112251	70552983
Altered state of consciousness	28.73	9.46	250	262960	39772	70625462
Transient ischaemic attack	28.44	9.46	278	262932	45666	70619568
Femoral neck fracture	28.32	9.46	86	263124	8987	70656247
Carcinoid tumour of the stomach	28.27	9.46	14	263196	180	70665054
Subarachnoid haemorrhage	28.14	9.46	145	263065	19359	70645875
Blood pressure increased	28.14	9.46	511	262699	188006	70477228
Lip dry	28.01	9.46	90	263120	9695	70655539
Syncope	27.90	9.46	809	262401	164900	70500334
Dyspepsia	27.80	9.46	475	262735	88602	70576632
Hepatotoxicity	27.64	9.46	78	263132	43908	70621326
Pneumonia aspiration	27.64	9.46	353	262857	61936	70603298
Basilar artery occlusion	27.60	9.46	14	263196	190	70665044
Pemphigoid	27.45	9.46	114	263096	13908	70651326
Abnormal loss of weight	27.39	9.46	77	263133	7707	70657527
Abdominal distension	27.38	9.46	543	262667	104126	70561108
Intentional product misuse	27.25	9.46	178	263032	79417	70585817
Constipation	27.21	9.46	1171	262039	251267	70413967
Subdural haematoma	27.07	9.46	194	263016	29104	70636130
Rectal ulcer	26.90	9.46	35	263175	1951	70663283
Gastric dysplasia	26.85	9.46	8	263202	20	70665214
Post viral fatigue syndrome	26.85	9.46	16	263194	303	70664931
Rheumatoid factor positive	26.75	9.46	91	263119	48309	70616925
Ventricular fibrillation	26.51	9.46	182	263028	26929	70638305
Rhabdomyolysis	26.48	9.46	501	262709	95259	70569975
Anaphylactic reaction	26.46	9.46	408	262802	74566	70590668
Urine potassium decreased	26.45	9.46	7	263203	9	70665225
Coordination abnormal	26.43	9.46	124	263086	15942	70649292
Hyperglycaemia	26.41	9.46	361	262849	64311	70600923
Gastric ulcer	26.26	9.46	205	263005	31585	70633649
Mixed liver injury	26.23	9.46	66	263144	6183	70659051
Haematotoxicity	26.18	9.46	9	263201	13665	70651569
Respiratory arrest	26.16	9.46	107	263103	53826	70611408
Nephrocalcinosis	26.05	9.46	29	263181	1372	70663862
Cystitis escherichia	25.77	9.46	19	263191	520	70664714
Adrenal insufficiency	25.75	9.46	171	263039	25024	70640210
Acne	25.64	9.46	33	263177	24956	70640278
Haematuria	25.60	9.46	354	262856	63219	70602015
Rhinorrhoea	25.57	9.46	143	263067	66228	70599006
Device malfunction	25.54	9.46	20	263190	19064	70646170
Somatic delusion	25.49	9.46	21	263189	679	70664555
Deep vein thrombosis postoperative	25.42	9.46	47	263163	3560	70661674
Musculoskeletal disorder	25.40	9.46	22	263188	19949	70645285
Barrett's oesophagus	25.39	9.46	22	263188	763	70664471
Drug interaction	25.19	9.46	1690	261520	379751	70285483
Dry mouth	25.08	9.46	384	262826	70073	70595161
Urine output decreased	25.07	9.46	127	263083	16843	70648391
Skin candida	25.03	9.46	32	263178	1753	70663481
Mouth ulceration	24.88	9.46	215	262995	34134	70631100
Hypophosphataemic osteomalacia	24.81	9.46	15	263195	292	70664942
Foot deformity	24.79	9.46	24	263186	20631	70644603
Joint stiffness	24.69	9.46	59	263151	35117	70630117
Therapeutic response delayed	24.51	9.46	24	263186	976	70664258
Hyperlipidaemia	24.41	9.46	162	263048	23701	70641533
Multiple sclerosis relapse	24.38	9.46	80	263130	42937	70622297
Full blood count decreased	24.12	9.46	32	263178	23886	70641348
Mouth swelling	24.04	9.46	58	263152	5291	70659943
Demyelination	23.93	9.46	70	263140	7166	70658068
Gastric varices	23.88	9.46	19	263191	584	70664650
Pain in extremity	23.87	9.46	985	262225	327097	70338137
Drug eruption	23.48	9.46	237	262973	39259	70625975
Purpura	23.46	9.46	130	263080	17845	70647389
Rebound acid hypersecretion	23.41	9.46	10	263200	89	70665145
Neuroendocrine tumour	23.38	9.46	27	263183	1330	70663904
Cardioactive drug level increased	23.35	9.46	45	263165	3517	70661717
Pathogen resistance	23.33	9.46	10	263200	13269	70651965
Erythema dyschromicum perstans	23.29	9.46	9	263201	60	70665174
Gastrointestinal tract irritation	22.94	9.46	18	263192	542	70664692
Renal atrophy	22.85	9.46	30	263180	1687	70663547
Enterocolitis haemorrhagic	22.81	9.46	33	263177	2035	70663199
Myocardial ischaemia	22.80	9.46	161	263049	24039	70641195
Inappropriate antidiuretic hormone secretion	22.60	9.46	156	263054	23120	70642114
Pericarditis	22.60	9.46	203	263007	84502	70580732
Immune reconstitution inflammatory syndrome	22.48	9.46	10	263200	12980	70652254
Occupational exposure to air contaminants	22.45	9.46	11	263199	138	70665096
Bradycardia	22.26	9.46	613	262597	124002	70541232
Marasmus	22.24	9.46	22	263188	906	70664328
Idiopathic pulmonary fibrosis	22.24	9.46	53	263157	4798	70660436
Hypersensitivity pneumonitis	22.15	9.46	43	263167	3379	70661855
Hyperuricaemia	22.13	9.46	90	263120	10876	70654358
Osteonecrosis of jaw	22.01	9.46	241	262969	40761	70624473
Aplastic anaemia	21.88	9.46	121	263089	16595	70648639
Hip fracture	21.81	9.46	45	263165	28218	70637016
Angina pectoris	21.81	9.46	275	262935	48108	70617126
Sleep disorder due to a general medical condition	21.67	9.46	6	263204	10470	70654764
Hyperparathyroidism secondary	21.48	9.46	36	263174	2522	70662712
Hypoglycaemic coma	21.47	9.46	49	263161	4312	70660922
Blood creatine phosphokinase increased	21.47	9.46	333	262877	60930	70604304
Device issue	21.44	9.46	35	263175	23990	70641244
Neuropathy, ataxia, retinitis pigmentosa syndrome	21.41	9.46	8	263202	48	70665186
Musculoskeletal stiffness	21.27	9.46	403	262807	147357	70517877
Renal cyst	21.23	9.46	102	263108	13243	70651991
Weight decreased	21.16	9.46	939	262271	309549	70355685
Neoplasm progression	21.14	9.46	91	263119	45137	70620097
Fluid retention	21.07	9.46	143	263067	63242	70601992
Device difficult to use	21.02	9.46	7	263203	10842	70654392
Premature delivery	20.98	9.46	29	263181	21275	70643959
Pituitary tumour benign	20.97	9.46	35	263175	2444	70662790
Iron deficiency anaemia	20.87	9.46	152	263058	22920	70642314
Unevaluable event	20.70	9.46	111	263099	51952	70613282
Muscle relaxant therapy	20.66	9.46	11	263199	166	70665068
White blood cell count increased	20.63	9.46	368	262842	69205	70596029
Abdominal pain upper	20.61	9.46	897	262313	192705	70472529
Gait disturbance	20.57	9.46	526	262684	184580	70480654
Alanine aminotransferase increased	20.35	9.46	703	262507	146777	70518457
Macroglossia	20.32	9.46	23	263187	1108	70664126
Cholecystitis	20.26	9.46	139	263071	20562	70644672
Ventricular hypertrophy	20.17	9.46	62	263148	6522	70658712
Blood albumin decreased	20.15	9.46	146	263064	21981	70643253
Blood pressure decreased	20.14	9.46	463	262747	91052	70574182
Condition aggravated	20.07	9.46	1342	261868	426293	70238941
Hyponatraemic syndrome	20.00	9.46	19	263191	744	70664490
Gastrointestinal haemorrhage	19.98	9.46	659	262551	136749	70528485
Adverse drug reaction	19.97	9.46	116	263094	53228	70612006
Gallbladder disorder	19.81	9.46	123	263087	17589	70647645
Dialysis	19.56	9.46	121	263089	17281	70647953
Illness	19.52	9.46	57	263153	31734	70633500
Drug dependence	19.40	9.46	72	263138	37249	70627985
Cardio-respiratory arrest	19.38	9.46	260	262950	100417	70564817
Face oedema	19.37	9.46	162	263048	25477	70639757
Extravasation blood	19.22	9.46	14	263196	376	70664858
Nocturia	19.21	9.46	93	263117	12111	70653123
Limb discomfort	19.17	9.46	52	263158	29653	70635581
Hypersensitivity	19.11	9.46	679	262531	229133	70436101
Renal tubular acidosis	18.89	9.46	40	263170	3346	70661888
Urticaria	18.84	9.46	762	262448	162287	70502947
Anal prolapse	18.75	9.46	8	263202	71	70665163
Transplant rejection	18.64	9.46	24	263186	18147	70647087
Pancreatic carcinoma recurrent	18.54	9.46	10	263200	155	70665079
Hepatic encephalopathy	18.48	9.46	143	263067	21975	70643259
Nephrosclerosis	18.31	9.46	27	263183	1694	70663540
Vulvovaginal candidiasis	18.17	9.46	32	263178	2334	70662900
Blood pressure systolic increased	18.14	9.46	131	263079	57128	70608106
Coma	18.11	9.46	236	262974	91608	70573626
Peripheral venous disease	17.96	9.46	83	263127	10604	70654630
Infection	17.94	9.46	621	262589	210164	70455070
Dilatation atrial	17.89	9.46	40	263170	3472	70661762
Cardiac murmur	17.86	9.46	91	263119	12095	70653139
Tachypnoea	17.84	9.46	51	263159	28587	70636647
Bone erosion	17.78	9.46	18	263192	15155	70650079
Dermatitis exfoliative	17.77	9.46	82	263128	10469	70654765
Peptic ulcer	17.69	9.46	54	263156	5659	70659575
Cardiac arrest	17.54	9.46	455	262755	159379	70505855
Microcytic anaemia	17.47	9.46	48	263162	4741	70660493
Oropharyngeal oedema	17.44	9.46	13	263197	362	70664872
Chromaturia	17.42	9.46	148	263062	23380	70641854
Red cell distribution width increased	17.42	9.46	15	263195	13642	70651592
Respiratory tract congestion	17.41	9.46	24	263186	17629	70647605
Hypoacusis	17.40	9.46	48	263162	27221	70638013
Alcoholic liver disease	17.37	9.46	15	263195	518	70664716
Pelvic cyst	17.36	9.46	7	263203	53	70665181
Panniculitis	17.28	9.46	9	263201	10667	70654567
Hiccups	17.26	9.46	73	263137	8979	70656255
Chronic gastritis	17.13	9.46	40	263170	3573	70661661
Cold sweat	17.09	9.46	115	263095	16901	70648333
Melanoderma	17.08	9.46	13	263197	374	70664860
Stoma site haemorrhage	17.03	9.46	26	263184	1683	70663551
Unintentional medical device removal	16.91	9.46	3	263207	7121	70658113
Acute coronary syndrome	16.87	9.46	130	263080	19949	70645285
Sinus congestion	16.76	9.46	24	263186	17349	70647885
Urinary retention	16.72	9.46	281	262929	52239	70612995
Infusion site streaking	16.72	9.46	14	263196	463	70664771
Laryngeal pain	16.68	9.46	53	263157	5675	70659559
Blood magnesium decreased	16.56	9.46	103	263107	14738	70650496
Hypophagia	16.54	9.46	231	262979	41339	70623895
Aortic dissection	16.53	9.46	41	263169	3806	70661428
Dermatitis bullous	16.47	9.46	92	263118	12665	70652569
Atypical fracture	16.46	9.46	16	263194	645	70664589
Cerebral mass effect	16.45	9.46	26	263184	1734	70663500
Arthritis	16.42	9.46	260	262950	97720	70567514
Embolic cerebral infarction	16.42	9.46	21	263189	1151	70664083
Oesophageal mucosal tear	16.38	9.46	5	263205	14	70665220
Renal hypertension	16.30	9.46	10	263200	200	70665034
Electrocardiogram QRS complex prolonged	16.27	9.46	8	263202	9798	70655436
Drug use disorder	16.25	9.46	5	263205	8146	70657088
Contraindication to medical treatment	16.23	9.46	21	263189	1164	70664070
Nightmare	16.21	9.46	139	263071	22017	70643217
Flashback	16.21	9.46	11	263199	263	70664971
Cerebellar infarction	16.20	9.46	38	263172	3404	70661830
Eye haemorrhage	16.16	9.46	71	263139	8878	70656356
Penile curvature	16.13	9.46	5	263205	15	70665219
Cholelithiasis	16.08	9.46	256	262954	47084	70618150
Knee arthroplasty	16.04	9.46	69	263141	34232	70631002
Neutrophil count increased	16.03	9.46	161	263049	26634	70638600
Paraesthesia oral	15.97	9.46	105	263105	15312	70649922
Alanine aminotransferase abnormal	15.96	9.46	5	263205	8054	70657180
Oral candidiasis	15.94	9.46	152	263058	24800	70640434
Sepsis	15.86	9.46	1082	262128	243463	70421771
Pharyngeal oedema	15.72	9.46	106	263104	15590	70649644
Bleeding time prolonged	15.64	9.46	21	263189	1207	70664027
Product substitution issue	15.63	9.46	120	263090	18393	70646841
Basal cell carcinoma	15.63	9.46	68	263142	33630	70631604
Temperature intolerance	15.60	9.46	69	263141	8654	70656580
Brain stem haemorrhage	15.54	9.46	24	263186	1569	70663665
Spleen congestion	15.48	9.46	13	263197	432	70664802
Staphylococcus test positive	15.47	9.46	53	263157	5901	70659333
Sinus node dysfunction	15.40	9.46	60	263150	7109	70658125
Blood gastrin increased	15.40	9.46	6	263204	41	70665193
Autonomic neuropathy	15.35	9.46	25	263185	1710	70663524
Therapeutic response shortened	15.31	9.46	15	263195	12823	70652411
Incorrect dose administered	15.24	9.46	166	263044	66553	70598681
Failure to anastomose	15.23	9.46	10	263200	226	70665008
Injection site mass	15.20	9.46	28	263182	18315	70646919
Gallbladder injury	15.13	9.46	20	263190	1132	70664102
Haemorrhagic cerebral infarction	15.06	9.46	22	263188	1369	70663865
Vasculitic rash	15.04	9.46	27	263183	1999	70663235
Mental status changes	14.81	9.46	156	263054	62945	70602289
Hepatorenal syndrome	14.77	9.46	40	263170	3917	70661317
Dermatitis acneiform	14.69	9.46	69	263141	8876	70656358
Pulmonary thrombosis	14.68	9.46	12	263198	11196	70654038
Follicular mucinosis	14.65	9.46	5	263205	22	70665212
Malignant melanoma	14.63	9.46	18	263192	13882	70651352
Ascites	14.63	9.46	341	262869	67206	70598028
Activated partial thromboplastin time prolonged	14.62	9.46	93	263117	13412	70651822
Urine phosphorus decreased	14.60	9.46	6	263204	48	70665186
Product quality issue	14.59	9.46	61	263149	30500	70634734
Rash maculo-papular	14.51	9.46	266	262944	50279	70614955
Sedation complication	14.51	9.46	17	263193	13393	70651841
Cholecystitis acute	14.50	9.46	85	263125	11909	70653325
Abortion spontaneous	14.49	9.46	50	263160	26429	70638805
Hypocalciuria	14.47	9.46	5	263205	23	70665211
Radiation pneumonitis	14.46	9.46	38	263172	3655	70661579
Coagulation test abnormal	14.37	9.46	20	263190	1190	70664044
Central nervous system lesion	14.34	9.46	15	263195	12438	70652796
Cardiotoxicity	14.31	9.46	12	263198	11058	70654176
Drug-induced liver injury	14.30	9.46	290	262920	55823	70609411
Fasciitis	14.29	9.46	16	263194	762	70664472
Post transplant lymphoproliferative disorder	14.17	9.46	11	263199	10534	70654700
Injection site haemorrhage	14.10	9.46	48	263162	25479	70639755
Joint dislocation	14.09	9.46	20	263190	14511	70650723
Foetal death	14.02	9.46	3	263207	6236	70658998
Blood cholinesterase decreased	13.94	9.46	10	263200	262	70664972
Hyperprolactinaemia	13.94	9.46	42	263168	4371	70660863
Bone pain	13.90	9.46	121	263089	50701	70614533
Dysuria	13.85	9.46	243	262967	45551	70619683
Renal disorder	13.85	9.46	208	263002	37801	70627433
Palpitations	13.82	9.46	522	262688	110231	70555003
Underdose	13.81	9.46	59	263151	29324	70635910
Oesophageal anastomosis	13.80	9.46	3	263207	0	70665234
Lip blister	13.80	9.46	29	263181	2413	70662821
Cerebral ventricular rupture	13.78	9.46	12	263198	419	70664815
Impaired quality of life	13.73	9.46	8	263202	8908	70656326
Disease progression	13.69	9.46	460	262750	156212	70509022
Lymphangiosis carcinomatosa	13.69	9.46	25	263185	1876	70663358
Pressure of speech	13.65	9.46	18	263192	1017	70664217
Intestinal ischaemia	13.63	9.46	84	263126	11980	70653254
Diabetic metabolic decompensation	13.62	9.46	33	263177	3019	70662215
Device use error	13.54	9.46	4	263206	6692	70658542
Muscle atrophy	13.53	9.46	75	263135	10295	70654939
Lymphocyte count decreased	13.52	9.46	232	262978	43307	70621927
Immunodeficiency	13.50	9.46	28	263182	17527	70647707
Heart rate decreased	13.49	9.46	156	263054	61859	70603375
Dissociation	13.49	9.46	35	263175	3341	70661893
Injection site warmth	13.43	9.46	19	263191	13806	70651428
Acute myocardial infarction	13.42	9.46	360	262850	72527	70592707
Rapid eye movement sleep behaviour disorder	13.39	9.46	11	263199	354	70664880
Multiple allergies	13.39	9.46	6	263204	7754	70657480
Respiratory muscle weakness	13.37	9.46	10	263200	280	70664954
Hypozincaemia	13.35	9.46	6	263204	61	70665173
Embolic stroke	13.29	9.46	58	263152	7231	70658003
Blood uric acid increased	13.26	9.46	68	263142	9061	70656173
Phyllodes tumour	13.25	9.46	5	263205	31	70665203
Disability	13.21	9.46	22	263188	14961	70650273
Ulcer	13.19	9.46	150	263060	25604	70639630
Cystitis	13.18	9.46	111	263099	46830	70618404
Osteoporosis	13.13	9.46	117	263093	48790	70616444
Skin oedema	13.10	9.46	22	263188	1544	70663690
Renal artery stenosis	13.07	9.46	34	263176	3250	70661984
Total lung capacity decreased	13.06	9.46	25	263185	1944	70663290
Gastroenteritis	13.05	9.46	175	263035	31038	70634196
Hypervolaemia	12.99	9.46	90	263120	39616	70625618
Hydronephrosis	12.98	9.46	99	263111	15143	70650091
Epstein-Barr virus infection	12.96	9.46	18	263192	13180	70652054
Cutaneous lupus erythematosus	12.93	9.46	31	263179	2817	70662417
Blood loss anaemia	12.92	9.46	21	263189	14420	70650814
Hallucination, visual	12.90	9.46	166	263044	29171	70636063
Glomerulosclerosis	12.89	9.46	17	263193	960	70664274
Breast cancer female	12.80	9.46	12	263198	10474	70654760
Wall motion score index abnormal	12.79	9.46	7	263203	112	70665122
Ischaemic nephropathy	12.73	9.46	5	263205	35	70665199
Hypotension	12.73	9.46	1310	261900	403071	70262163
Mouth haemorrhage	12.69	9.46	73	263137	10158	70655076
Hypochloraemia	12.69	9.46	26	263184	2125	70663109
Glossitis	12.67	9.46	34	263176	3312	70661922
Blood parathyroid hormone decreased	12.66	9.46	9	263201	9015	70656219
Food allergy	12.64	9.46	8	263202	8516	70656718
Central nervous system mass	12.62	9.46	7	263203	115	70665119
Bile duct stone	12.57	9.46	45	263165	5121	70660113
Hypoglycaemia	12.56	9.46	448	262762	93916	70571318
Putamen haemorrhage	12.53	9.46	12	263198	475	70664759
Abnormal faeces	12.52	9.46	53	263157	6520	70658714
Clostridium test positive	12.52	9.46	43	263167	4793	70660441
Skin necrosis	12.52	9.46	26	263184	16265	70648969
Injury	12.52	9.46	324	262886	64921	70600313
Hypoalbuminaemia	12.47	9.46	117	263093	19005	70646229
Gastrointestinal stoma output increased	12.41	9.46	9	263201	240	70664994
Substance abuse	12.31	9.46	11	263199	9826	70655408
Oculomucocutaneous syndrome	12.31	9.46	10	263200	317	70664917
Poor venous access	12.28	9.46	23	263187	14948	70650286
Multiple organ dysfunction syndrome	12.27	9.46	506	262704	108009	70557225
Hypoperfusion	12.26	9.46	28	263182	2465	70662769
Genital ulceration	12.20	9.46	14	263196	685	70664549
Rectal ulcer haemorrhage	12.16	9.46	9	263201	248	70664986
Adverse event	12.14	9.46	121	263089	49340	70615894
Myelosuppression	12.13	9.46	64	263146	30081	70635153
Autoimmune disorder	12.10	9.46	64	263146	8632	70656602
Product monitoring error	12.07	9.46	5	263205	6771	70658463
Gastric ulcer haemorrhage	12.06	9.46	63	263147	8455	70656779
Mesenteric artery embolism	12.06	9.46	6	263204	78	70665156
Tongue disorder	12.05	9.46	19	263191	13208	70652026
Heart rate irregular	12.05	9.46	63	263147	29680	70635554
Vascular skin disorder	12.02	9.46	4	263206	16	70665218
Vulval haemorrhage	12.02	9.46	4	263206	16	70665218
Burning feet syndrome	12.02	9.46	8	263202	185	70665049
Violence-related symptom	11.99	9.46	14	263196	698	70664536
Gamma-glutamyltransferase increased	11.96	9.46	259	262951	50426	70614808
N-telopeptide urine increased	11.95	9.46	5	263205	42	70665192
Strangury	11.95	9.46	8	263202	187	70665047
Generalised bullous fixed drug eruption	11.91	9.46	7	263203	129	70665105
Pneumocystis jirovecii pneumonia	11.90	9.46	167	263043	29915	70635319
Erythema	11.90	9.46	877	262333	198686	70466548
Ileus	11.89	9.46	140	263070	24097	70641137
Product complaint	11.89	9.46	82	263128	12149	70653085
Tongue discolouration	11.87	9.46	34	263176	3440	70661794
Discoloured vomit	11.86	9.46	19	263191	1282	70663952
Aphasia	11.86	9.46	226	262984	43023	70622211
Procedural failure	11.86	9.46	6	263204	81	70665153
Drug level below therapeutic	11.85	9.46	9	263201	8714	70656520
Sinus bradycardia	11.84	9.46	137	263073	23486	70641748
Rash papulosquamous	11.82	9.46	7	263203	131	70665103
Haemoglobin decreased	11.80	9.46	899	262311	204260	70460974
Rash erythematous	11.79	9.46	263	262947	51455	70613779
Skin toxicity	11.75	9.46	6	263204	7192	70658042
Sinobronchitis	11.75	9.46	5	263205	44	70665190
Anti A antibody	11.73	9.46	3	263207	3	70665231
Lymphadenopathy	11.71	9.46	120	263090	48671	70616563
Colon cancer	11.68	9.46	92	263118	14214	70651020
Oral mucosal discolouration	11.66	9.46	10	263200	342	70664892
Incision site complication	11.66	9.46	14	263196	719	70664515
Laryngotracheal oedema	11.66	9.46	5	263205	45	70665189
Discharge	11.63	9.46	18	263192	1179	70664055
Wheezing	11.55	9.46	443	262767	93727	70571507
Pharyngotonsillitis	11.53	9.46	9	263201	269	70664965
Immobilisation syndrome	11.51	9.46	11	263199	434	70664800
Inflammatory bowel disease	11.47	9.46	43	263167	5003	70660231
Laboratory test abnormal	11.44	9.46	53	263157	25770	70639464
Helicobacter test positive	11.38	9.46	18	263192	1201	70664033
Oesophageal carcinoma recurrent	11.38	9.46	5	263205	48	70665186
Urine calcium/creatinine ratio increased	11.37	9.46	7	263203	141	70665093
Dermatitis atopic	11.36	9.46	10	263200	8997	70656237
Prostatic specific antigen increased	11.36	9.46	11	263199	9455	70655779
Congenital bowing of long bones	11.31	9.46	4	263206	20	70665214
Urinary straining	11.29	9.46	5	263205	49	70665185
Lymphocyte stimulation test positive	11.25	9.46	17	263193	1090	70664144
Rash morbilliform	11.19	9.46	45	263165	5410	70659824
Aortic aneurysm rupture	11.16	9.46	18	263192	1221	70664013
Uveitis	11.15	9.46	24	263186	14821	70650413
Atrioventricular block	11.14	9.46	83	263127	12605	70652629
Gastroenteritis staphylococcal	11.14	9.46	9	263201	283	70664951
Complication of device insertion	11.13	9.46	3	263207	5329	70659905
Erythema annulare	11.07	9.46	7	263203	148	70665086
Gallbladder hypofunction	11.06	9.46	11	263199	456	70664778
Medication error	11.03	9.46	283	262927	56629	70608605
Product prescribing error	10.99	9.46	92	263118	38860	70626374
Joint injury	10.94	9.46	57	263153	26875	70638359
Parakeratosis	10.93	9.46	10	263200	373	70664861
Transplant dysfunction	10.93	9.46	6	263204	6903	70658331
Respiratory tract oedema	10.91	9.46	14	263196	770	70664464
Cardiomegaly	10.84	9.46	139	263071	24406	70640828
Acanthosis	10.81	9.46	11	263199	469	70664765
Atypical femur fracture	10.79	9.46	41	263169	4802	70660432
Gynaecomastia	10.74	9.46	52	263158	6771	70658463
Presyncope	10.74	9.46	197	263013	37241	70627993
Regurgitation	10.72	9.46	25	263185	2231	70663003
Pulmonary fibrosis	10.71	9.46	183	263027	34127	70631107
Post cardiac arrest syndrome	10.71	9.46	4	263206	24	70665210
Rectocele	10.67	9.46	12	263198	574	70664660
General physical health deterioration	10.67	9.46	743	262467	235288	70429946
Hypoaesthesia	10.65	9.46	464	262746	153275	70511959
Herpes zoster	10.62	9.46	238	262972	84997	70580237
Cystitis noninfective	10.62	9.46	18	263192	1273	70663961
Oedema	10.59	9.46	478	262732	103103	70562131
Rash vesicular	10.57	9.46	43	263167	5197	70660037
Paramnesia	10.57	9.46	4	263206	25	70665209
Papule	10.49	9.46	51	263159	6652	70658582
Lung opacity	10.49	9.46	34	263176	3679	70661555
Hospice care	10.48	9.46	9	263201	8196	70657038
Acute graft versus host disease	10.48	9.46	12	263198	9550	70655684
Fibrin degradation products increased	10.47	9.46	9	263201	309	70664925
Tumour haemorrhage	10.44	9.46	34	263176	3688	70661546
Myositis	10.42	9.46	105	263105	17384	70647850
Hyperlipasaemia	10.38	9.46	16	263194	1044	70664190
Surgery	10.29	9.46	67	263143	29922	70635312
Meniere's disease	10.29	9.46	7	263203	168	70665066
Thrombotic cerebral infarction	10.29	9.46	11	263199	497	70664737
Periprosthetic fracture	10.28	9.46	12	263198	598	70664636
Gingivitis	10.26	9.46	59	263151	8211	70657023
Hemiparesis	10.25	9.46	169	263041	31300	70633934
Diffuse vasculitis	10.24	9.46	6	263204	110	70665124
Narrow anterior chamber angle	10.22	9.46	7	263203	170	70665064
Finger deformity	10.19	9.46	5	263205	6131	70659103
Rash macular	10.18	9.46	142	263068	25402	70639832
Feeling of body temperature change	10.16	9.46	41	263169	4938	70660296
Paradoxical drug reaction	10.15	9.46	6	263204	6630	70658604
Cerebral hyperperfusion syndrome	10.14	9.46	6	263204	112	70665122
Pyelonephritis acute	10.14	9.46	44	263166	5473	70659761
Thrombosis	10.14	9.46	208	263002	75197	70590037
Hepatic cancer metastatic	10.13	9.46	14	263196	827	70664407
Dialysis hypotension	10.12	9.46	5	263205	64	70665170
Metaplasia	10.11	9.46	10	263200	412	70664822
Pleuritic pain	10.09	9.46	62	263148	8835	70656399
Drug tolerance decreased	10.07	9.46	13	263197	9820	70655414
Mucormycosis	9.98	9.46	9	263201	8005	70657229
Small intestinal haemorrhage	9.98	9.46	35	263175	3943	70661291
Fat redistribution	9.96	9.46	6	263204	116	70665118
Gamma-glutamyltransferase	9.95	9.46	4	263206	30	70665204
Hepatic atrophy	9.91	9.46	10	263200	422	70664812
Progressive multifocal leukoencephalopathy	9.88	9.46	112	263098	19102	70646132
Oesophageal ulcer	9.87	9.46	49	263161	6445	70658789
Blood electrolytes increased	9.85	9.46	5	263205	68	70665166
Physical deconditioning	9.83	9.46	19	263191	1488	70663746
Gastrointestinal stoma output decreased	9.82	9.46	6	263204	119	70665115
Sputum retention	9.80	9.46	15	263195	973	70664261
Sterile pyuria	9.78	9.46	5	263205	69	70665165
Nasal mucosal erosion	9.78	9.46	5	263205	69	70665165
Chondrocalcinosis	9.78	9.46	13	263197	740	70664494
Morbid thoughts	9.74	9.46	13	263197	743	70664491
Pre-eclampsia	9.73	9.46	6	263204	6479	70658755
Dysentery	9.73	9.46	15	263195	979	70664255
Periorbital discomfort	9.73	9.46	4	263206	32	70665202
Electrocardiogram ST-T segment abnormal	9.72	9.46	11	263199	530	70664704
Gastric varices haemorrhage	9.70	9.46	9	263201	342	70664892
Oropharyngeal swelling	9.70	9.46	17	263193	1235	70663999
Culture throat positive	9.68	9.46	3	263207	9	70665225
Drug tolerance	9.67	9.46	8	263202	7420	70657814
Sluggishness	9.63	9.46	5	263205	5938	70659296
Stevens-Johnson syndrome	9.63	9.46	187	263023	35720	70629514
Malignant neoplasm progression	9.61	9.46	548	262662	121191	70544043
Platelet transfusion	9.56	9.46	23	263187	2095	70663139
Large intestinal ulcer	9.54	9.46	37	263173	4375	70660859
Onychomycosis	9.53	9.46	7	263203	6894	70658340
Single functional kidney	9.52	9.46	6	263204	126	70665108
Gastrointestinal toxicity	9.51	9.46	6	263204	6399	70658835
Abdominal wound dehiscence	9.49	9.46	8	263202	267	70664967

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A02BC03	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Proton pump inhibitors
ATC	A02BC53	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Proton pump inhibitors
ATC	A02BD02	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori
ATC	A02BD03	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori
ATC	A02BD07	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori
ATC	A02BD09	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori
ATC	A02BD10	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori
FDA MoA	N0000000147	Proton Pump Inhibitors
FDA PE	N0000009724	Inhibition Gastric Acid Secretion
FDA EPC	N0000175525	Proton Pump Inhibitor
CHEBI has role	CHEBI:49200	proton pump inhibitors
CHEBI has role	CHEBI:49201	anti-ulcer drugs
MeSH PA	D000897	Anti-Ulcer Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D054328	Proton Pump Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Peptic ulcer	indication	13200003	DOID:750
Erosive esophagitis	indication	40719004
Duodenal ulcer disease	indication	51868009	DOID:1724
Zollinger-Ellison syndrome	indication	53132006	DOID:0050782
Gastroesophageal reflux disease	indication	235595009	DOID:8534
Gastric ulcer	indication	397825006	DOID:10808
NSAID-Induced Gastric Ulcer	indication
Gastric Hypersecretory Conditions	indication
Duodenal Ulcer due to H. Pylori	indication
Maintenance of Healing Duodenal Ulcer	indication
Upper gastrointestinal hemorrhage	off-label use	37372002
Pathological Gastric Hypersecretory Condition	off-label use
Prevention of Stress Ulcer	off-label use
Prevention of Acute Gastrointestinal Ulcer Re-Bleed	off-label use
Alcoholism	contraindication	7200002
Myocardial infarction	contraindication	22298006	DOID:5844
Ventricular tachycardia	contraindication	25569003
Obstruction of bile duct	contraindication	30144000
Torsades de pointes	contraindication	31722008
Hypertensive disorder	contraindication	38341003	DOID:10763
Gastrointestinal ulcer	contraindication	40845000
Body fluid retention	contraindication	43498006
Chronic heart failure	contraindication	48447003
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Blood coagulation disorder	contraindication	64779008	DOID:1247
Osteoporosis	contraindication	64859006	DOID:11476
Gastrointestinal hemorrhage	contraindication	74474003
Kidney disease	contraindication	90708001	DOID:557
Myasthenia gravis	contraindication	91637004	DOID:437
Cholestatic hepatitis	contraindication	95556007
Prolonged QT interval	contraindication	111975006
Fracture of bone	contraindication	125605004
Liver function tests abnormal	contraindication	166603001
Hypomagnesemia	contraindication	190855004
Cerebrovascular accident	contraindication	230690007
Coronary artery bypass graft	contraindication	232717009
Disease of liver	contraindication	235856003	DOID:409
Esophageal dysmotility	contraindication	266434009	DOID:9192
Edema	contraindication	267038008
Infectious mononucleosis	contraindication	271558008	DOID:8568
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thromboembolic disorder	contraindication	371039008
Cardiovascular event risk	contraindication	395112001
Pseudomembranous enterocolitis	contraindication	397683000
Porphyria	contraindication	418470004
Smokes tobacco daily	contraindication	449868002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.23	acidic
pKa2	3.35	Basic
pKa3	2.72	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Potassium-transporting ATPase	Transporter	P20648 P51164	ATP4A_HUMAN ATP4B_HUMAN	INHIBITOR			CHEMBL	CHEMBL
Cytochrome P450 2C19	Enzyme	P33261	CP2CJ_HUMAN		IC50	6.47	DRUG MATRIX
Fatty acid synthase	Enzyme	P49327	FAS_HUMAN		Ki	5.28	CHEMBL
Phosphoethanolamine/phosphocholine phosphatase	Enzyme	Q8TCT1	PHOP1_HUMAN		IC50	6.36	CHEMBL
Microtubule-associated protein tau	Structural	P10636	TAU_HUMAN		Ki	8.60	CHEMBL
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Enzyme	O94760	DDAH1_HUMAN		IC50	4.29	CHEMBL
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	5.28	DRUG MATRIX
Cytosolic endo-beta-N-acetylglucosaminidase	Enzyme	Q8NFI3	ENASE_HUMAN		IC50	4.61	CHEMBL
Indoleamine 2,3-dioxygenase 2	Enzyme		I23O2_MOUSE		IC50	5.09	CHEMBL
Indoleamine 2,3-dioxygenase 1	Enzyme		I23O1_MOUSE		IC50	4.03	CHEMBL

External reference:

ID	Source
D00355	KEGG_DRUG
4020922	VANDF
C0050940	UMLSCUI
CHEBI:6375	CHEBI
CHEMBL480	ChEMBL_ID
DB00448	DRUGBANK_ID
D064747	MESH_DESCRIPTOR_UI
3883	PUBCHEM_CID
7208	IUPHAR_LIGAND_ID
6397	INN_ID
0K5C5T2QPG	UNII
17128	RXNORM
169151	MMSL
330	MMSL
4958	MMSL
d03828	MMSL
004456	NDDF
108666007	SNOMEDCT_US
386888004	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Prevacid24 HR	HUMAN OTC DRUG LABEL	1	0067-6286	CAPSULE, DELAYED RELEASE	15 mg	ORAL	NDA	15 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3008	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	15 mg	ORAL	ANDA	29 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3008	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	15 mg	ORAL	ANDA	29 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3008	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	15 mg	ORAL	ANDA	29 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3009	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	30 mg	ORAL	ANDA	29 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3009	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	30 mg	ORAL	ANDA	29 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3009	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	30 mg	ORAL	ANDA	29 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7350	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	27 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7350	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	27 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7350	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	27 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7351	CAPSULE, DELAYED RELEASE	30 mg	ORAL	ANDA	27 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7351	CAPSULE, DELAYED RELEASE	30 mg	ORAL	ANDA	27 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7351	CAPSULE, DELAYED RELEASE	30 mg	ORAL	ANDA	27 sections
Good Sense Lansoprazole	HUMAN OTC DRUG LABEL	1	0113-0116	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	15 mg	ORAL	NDA	16 sections
Good Sense lansoprazole	HUMAN OTC DRUG LABEL	1	0113-0117	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	16 sections
Good Sense Lansoprazole	HUMAN OTC DRUG LABEL	1	0113-1114	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	16 sections
Prevacid 24 HR	HUMAN OTC DRUG LABEL	1	0113-6002	CAPSULE, DELAYED RELEASE	15 mg	ORAL	NDA	16 sections
Prevacid 24 HR	HUMAN OTC DRUG LABEL	1	0113-6002	CAPSULE, DELAYED RELEASE	15 mg	ORAL	NDA	16 sections
Basic Care Lansoprazole	HUMAN OTC DRUG LABEL	1	0113-7003	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	16 sections
basic care lansoprazole	HUMAN OTC DRUG LABEL	1	0113-7116	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	15 mg	ORAL	NDA	16 sections
Lansoprazole	HUMAN OTC DRUG LABEL	1	0363-0739	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	15 sections
lansoprazole	HUMAN OTC DRUG LABEL	1	0363-1212	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	16 sections
Lansoprazole	HUMAN OTC DRUG LABEL	1	0363-1419	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	15 mg	ORAL	NDA	16 sections
Lansoprazole	HUMAN OTC DRUG LABEL	1	0363-4069	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	16 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-6981	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	15 mg	ORAL	ANDA	29 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-6981	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	15 mg	ORAL	ANDA	29 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-6982	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	30 mg	ORAL	ANDA	29 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-6982	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	30 mg	ORAL	ANDA	29 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-8015	CAPSULE, DELAYED RELEASE PELLETS	15 mg	ORAL	ANDA	30 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-8015	CAPSULE, DELAYED RELEASE PELLETS	15 mg	ORAL	ANDA	30 sections