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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
antiulcer, benzimidazole derivatives	1547	103577-45-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: prevacid lansoprazole A-65006 AG 1749 AG-1749	A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers. Molecular weight: 369.36 Formula: C16H14F3N3O2S CLOGP: 2.79 LIPINSKI: 0 HAC: 5 HDO: 1 TPSA: 67.87 ALOGS: -3.17 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

prevacid
lansoprazole
A-65006
AG 1749
AG-1749

A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.

Molecular weight: 369.36
Formula: C16H14F3N3O2S
CLOGP: 2.79
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 67.87
ALOGS: -3.17
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
30	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.00 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	1.35 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	81 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.28 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	4.40 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.02 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	1 hours	Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP3K1,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PDK1,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ZAP70	50
kinase-selectivity-class	AXL	1
mdck-mdr1-bcrp-efflux	MDCK-MDR1-BCRP efflux ratio	4.436		High	1
pfas-class	PFAS structural alert (1 = True, 0 = False)	1
pld-class	Phospholipidosis risk class (1 = positive, 0 = negative)	1		Moderate	0.73
rat-kpuu-brain	Rat brain Kpuu	0.216	%	High	1

Approvals:

Date	Agency	Company	Orphan
May 10, 1995	FDA	TAKEDA PHARMS USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	984.84	9.12	2171	319948	1382127	88924201
Chronic kidney disease	750.40	9.12	909	321210	49282	90257046
Colitis microscopic	541.29	9.12	390	321729	10769	90295559
Renal injury	362.91	9.12	297	321822	9946	90296382
Hyponatraemia	335.12	9.12	1141	320978	132397	90173931
Completed suicide	333.38	9.12	57	322062	145001	90161327
Product dose omission issue	309.59	9.12	348	321771	291339	90014989
Off label use	263.23	9.12	2579	319540	1099673	89206655
Death	246.09	9.12	817	321302	455734	89850594
End stage renal disease	239.57	9.12	217	321902	8354	90297974
Acute kidney injury	239.22	9.12	1951	320168	318436	89987892
Therapeutic product effect incomplete	235.97	9.12	205	321914	193691	90112637
Swollen tongue	208.52	9.12	487	321632	45469	90260859
Fatigue	207.08	9.12	2876	319243	1151147	89155181
Pain	201.52	9.12	2421	319698	993920	89312408
Chest pain	194.34	9.12	1861	320258	317784	89988544
Toxicity to various agents	189.54	9.12	468	321651	287378	90018950
Hypomagnesaemia	185.98	9.12	399	321720	35189	90271139
Angioedema	183.01	9.12	577	321542	64299	90242029
Injection site pain	180.10	9.12	211	321908	173488	90132840
Subacute cutaneous lupus erythematosus	173.28	9.12	125	321994	3457	90302871
Lip swelling	164.19	9.12	399	321720	38211	90268117
Lower respiratory tract infection	159.59	9.12	1474	320645	249185	90057143
Contraindicated product administered	153.69	9.12	601	321518	319538	89986790
Liver disorder	145.14	9.12	830	321289	120439	90185889
Deep vein thrombosis postoperative	133.36	9.12	552	321567	70257	90236071
Interstitial lung disease	127.31	9.12	574	321545	75831	90230497
Abdominal pain upper	126.20	9.12	1768	320351	330906	89975422
Lower limb fracture	125.08	9.12	616	321503	84397	90221931
Exposure during pregnancy	122.58	9.12	435	321684	237975	90068353
Injection site reaction	121.18	9.12	90	322029	91990	90214338
Neutropenic sepsis	117.08	9.12	222	321897	17908	90288420
Cardiospasm	113.92	9.12	96	322023	3350	90302978
Autoimmune disorder	113.56	9.12	557	321562	76187	90230141
Hypertensive nephropathy	113.22	9.12	53	322066	625	90305703
Palmoplantar keratoderma	112.45	9.12	96	322023	3411	90302917
Swelling face	112.32	9.12	579	321540	80773	90225555
Device expulsion	111.31	9.12	9	322110	40877	90265451
Renal failure	109.87	9.12	820	321299	130187	90176141
Subarachnoid haemorrhage	108.00	9.12	213	321906	17691	90288637
Electric shock	106.71	9.12	70	322049	1652	90304676
Lip dry	103.63	9.12	664	321455	100291	90206037
Pruritus genital	101.89	9.12	102	322017	4456	90301872
Drug intolerance	101.75	9.12	1058	321061	446533	89859795
X-ray abnormal	100.86	9.12	373	321746	45051	90261277
Sleep terror	98.14	9.12	99	322020	4365	90301963
Adjustment disorder with depressed mood	97.27	9.12	430	321689	56323	90250005
Urticaria	96.19	9.12	1604	320515	311130	89995198
Cerebral infarction	95.62	9.12	258	321861	26338	90279990
Inappropriate schedule of product administration	94.57	9.12	249	321870	149684	90156644
Accidental exposure to product	94.37	9.12	18	322101	42348	90263980
Amnesia	92.59	9.12	682	321437	107823	90198505
Confusional state	91.11	9.12	1901	320218	384304	89922024
Atrial tachycardia	90.31	9.12	109	322010	5881	90300447
Tubulointerstitial nephritis	89.26	9.12	244	321875	25099	90281229
Treatment failure	87.63	9.12	676	321443	303252	90003076
Therapeutic product effect decreased	87.42	9.12	602	321517	276969	90029359
Agranulocytosis	85.03	9.12	296	321823	34706	90271622
Macular degeneration	82.76	9.12	17	322102	37953	90268375
Melaena	82.57	9.12	292	321827	34505	90271823
Peripheral venous disease	79.48	9.12	541	321578	83380	90222948
Hepatic function abnormal	78.79	9.12	350	321769	45938	90260390
Tension headache	78.22	9.12	114	322005	7395	90298933
Drug abuse	78.07	9.12	107	322012	82240	90224088
Immunisation	78.04	9.12	64	322055	2149	90304179
Product use issue	77.75	9.12	773	321346	329146	89977182
Oedema	76.88	9.12	1067	321052	199228	90107100
Carotid artery occlusion	76.05	9.12	103	322016	6239	90300089
Liver injury	75.65	9.12	933	321186	169634	90136694
Injection site erythema	74.74	9.12	148	321971	98354	90207974
Suicide attempt	74.51	9.12	95	322024	75304	90231024
Blood pressure increased	73.93	9.12	405	321714	196812	90109516
Lupus vulgaris	73.17	9.12	336	321783	44723	90261605
Wheezing	72.75	9.12	1220	320899	236860	90069468
Therapy interrupted	72.61	9.12	44	322075	50064	90256264
Abdominal pain	72.36	9.12	1880	320239	393841	89912487
Blood lactic acid decreased	72.11	9.12	34	322085	408	90305920
Injection site swelling	71.86	9.12	64	322055	59775	90246553
Lung disorder	71.79	9.12	832	321287	149051	90157277
Injection site pruritus	71.63	9.12	52	322067	53782	90252546
Influenza	71.61	9.12	254	321865	139010	90167318
Delirium	70.56	9.12	622	321497	103737	90202591
Myelosuppression	69.71	9.12	53	322066	53538	90252790
Road traffic accident	68.95	9.12	634	321485	106992	90199336
Haematemesis	68.34	9.12	269	321850	33457	90272871
Loss of personal independence in daily activities	68.15	9.12	251	321868	135854	90170474
Dry mouth	67.22	9.12	972	321147	183087	90123241
Cholecystitis chronic	66.79	9.12	123	321996	9703	90296625
Foetal exposure during pregnancy	66.20	9.12	35	322084	42940	90263388
Rectal haemorrhage	66.03	9.12	512	321607	82232	90224096
Pulmonary fibrosis	65.73	9.12	627	321492	106876	90199452
Maternal exposure during pregnancy	65.30	9.12	894	321225	359169	89947159
COVID-19	64.79	9.12	344	321775	168499	90137829
Porphyria acute	63.24	9.12	173	321946	17802	90288526
Cardiac output increased	62.96	9.12	33	322086	504	90305824
Vitamin B1 decreased	62.91	9.12	33	322086	505	90305823
Onychomycosis	62.84	9.12	27	322092	37349	90268979
Swollen joint count increased	61.87	9.12	636	321483	110570	90195758
Hallucination	61.73	9.12	424	321695	65535	90240793
Diabetic nephropathy	60.84	9.12	50	322069	1684	90304644
Type 2 diabetes mellitus	60.44	9.12	1037	321082	202207	90104121
Musculoskeletal pain	60.42	9.12	899	321220	170352	90135976
Intervertebral discitis	59.74	9.12	77	322042	4443	90301885
Joint range of motion decreased	59.72	9.12	741	321378	134902	90171426
Asthma	59.67	9.12	1200	320919	240960	90065368
C-reactive protein	58.63	9.12	244	321875	31123	90275205
Nephrogenic anaemia	58.49	9.12	57	322062	2409	90303919
Cholestasis	58.44	9.12	270	321849	36029	90270299
Wrong technique in product usage process	58.30	9.12	103	322016	71468	90234860
Facial pain	57.94	9.12	138	321981	13044	90293284
Dislocation of vertebra	57.35	9.12	368	321751	55600	90250728
Bursitis	57.01	9.12	717	321402	130937	90175391
Hepatotoxicity	56.29	9.12	48	322071	45794	90260534
Reaction to excipient	55.77	9.12	49	322070	1811	90304517
Total lung capacity decreased	55.50	9.12	68	322051	3727	90302601
Subcutaneous drug absorption impaired	55.48	9.12	138	321981	13407	90292921
Labile blood pressure	54.64	9.12	49	322070	1861	90304467
Food allergy	54.31	9.12	12	322107	25466	90280862
Device dislocation	54.13	9.12	22	322097	31460	90274868
Blood cholesterol increased	54.01	9.12	1039	321080	206973	90099355
Muscle twitching	53.95	9.12	199	321920	24003	90282325
Mixed liver injury	53.82	9.12	97	322022	7526	90298802
Rebound acid hypersecretion	53.58	9.12	26	322093	334	90305994
Rhinorrhoea	53.18	9.12	150	321969	88166	90218162
Drug resistance	52.80	9.12	21	322098	30428	90275900
Foetal death	52.62	9.12	6	322113	20717	90285611
Hypokalaemia	52.54	9.12	704	321415	130412	90175916
Red blood cell sedimentation rate abnormal	52.41	9.12	11	322108	24193	90282135
Nephropathy	52.27	9.12	107	322012	9128	90297200
Overdose	52.15	9.12	337	321782	157372	90148956
Pancreatitis	51.85	9.12	425	321694	69401	90236927
Rash vesicular	50.52	9.12	161	321958	18036	90288292
Decreased appetite	50.11	9.12	1720	320399	374820	89931508
Muscle injury	49.89	9.12	894	321225	175760	90130568
Sopor	49.47	9.12	196	321923	24448	90281880
Anosmia	48.70	9.12	108	322011	9740	90296588
Immunodeficiency	48.68	9.12	49	322070	43185	90263143
Injury	48.62	9.12	978	321141	196371	90109957
C-reactive protein abnormal	48.53	9.12	678	321441	126751	90179577
Bronchopulmonary aspergillosis allergic	47.97	9.12	63	322056	3703	90302625
Post cholecystectomy syndrome	47.85	9.12	33	322086	848	90305480
Glomerular filtration rate increased	47.71	9.12	47	322072	2013	90304315
Hypocalcaemia	47.43	9.12	285	321834	42083	90264245
Therapy cessation	47.24	9.12	36	322083	36325	90270003
Hepatocellular injury	47.06	9.12	216	321903	28742	90277586
Intentional overdose	47.00	9.12	173	321946	93661	90212667
Hypergastrinaemia	46.96	9.12	18	322101	123	90306205
Joint swelling	46.44	9.12	1398	320721	501902	89804426
Wound infection	46.28	9.12	580	321539	105822	90200506
Grip strength	46.24	9.12	100	322019	8865	90297463
Adverse reaction	46.06	9.12	24	322095	29688	90276640
Liver function test abnormal	45.32	9.12	323	321796	50522	90255806
Product dose omission in error	45.06	9.12	9	322110	20494	90285834
Night sweats	45.02	9.12	675	321444	128091	90178237
Brain stem glioma	44.98	9.12	19	322100	172	90306156
Abortion spontaneous	44.74	9.12	77	322042	53979	90252349
Demyelination	44.53	9.12	93	322026	8047	90298281
Illness	43.82	9.12	147	321972	81822	90224506
Infective pulmonary exacerbation of cystic fibrosis	43.45	9.12	106	322013	10173	90296155
Obesity	43.31	9.12	569	321550	104938	90201390
Oedema peripheral	43.28	9.12	1212	320907	256703	90049625
Coeliac disease	43.26	9.12	57	322062	44553	90261775
Disease progression	42.94	9.12	353	321766	156262	90150066
Aspiration	42.80	9.12	138	321981	15555	90290773
Respiratory tract congestion	42.70	9.12	22	322097	27388	90278940
Transient ischaemic attack	41.86	9.12	280	321839	42896	90263432
Back injury	41.80	9.12	63	322056	46559	90259769
Breast cancer stage II	41.04	9.12	240	321879	35094	90271234
Lung opacity	40.99	9.12	76	322043	6026	90300302
Renal impairment	40.17	9.12	561	321558	104860	90201468
Facet joint syndrome	40.12	9.12	530	321589	97859	90208469
Myositis	39.97	9.12	181	321938	23947	90282381
Eye injury	39.71	9.12	107	322012	10913	90295415
Post-traumatic stress disorder	39.70	9.12	80	322039	6748	90299580
Injection site bruising	39.32	9.12	79	322040	52228	90254100
Neoplasm progression	39.03	9.12	61	322058	44425	90261903
Stress	38.86	9.12	153	321966	81242	90225086
Biliary dyskinesia	38.70	9.12	47	322072	2552	90303776
Therapy partial responder	38.56	9.12	15	322104	22028	90284300
Arthralgia	38.37	9.12	2321	319798	776201	89530127
No adverse event	38.37	9.12	119	322000	67863	90238465
Skin haemorrhage	38.32	9.12	14	322105	21366	90284962
General symptom	38.22	9.12	127	321992	14541	90291787
Hospitalisation	37.78	9.12	283	321836	127817	90178511
Upper respiratory tract inflammation	37.66	9.12	47	322072	2625	90303703
Multiple sclerosis relapse	37.63	9.12	81	322038	52224	90254104
Sciatica	37.63	9.12	537	321582	100845	90205483
Inappropriate antidiuretic hormone secretion	37.45	9.12	153	321966	19352	90286976
Proctitis	37.32	9.12	5	322114	15254	90291074
Pleuritic pain	37.12	9.12	101	322018	10360	90295968
Pustular psoriasis	36.78	9.12	147	321972	18409	90287919
White blood cell count increased	36.65	9.12	383	321736	66858	90239470
Reflux gastritis	36.23	9.12	34	322085	1370	90304958
Lethargy	36.01	9.12	363	321756	62776	90243552
Pemphigoid	35.96	9.12	91	322028	8935	90297393
Product storage error	35.03	9.12	14	322105	20227	90286101
Hyperlactacidaemia	34.95	9.12	57	322062	4079	90302249
Cholecystitis acute	34.58	9.12	92	322027	9312	90297016
Onychomadesis	34.13	9.12	70	322049	45928	90260400
International normalised ratio increased	34.06	9.12	286	321833	47030	90259298
Alopecia	34.01	9.12	1426	320693	493645	89812683
Coma scale abnormal	34.01	9.12	67	322052	5559	90300769
Device difficult to use	34.00	9.12	10	322109	17515	90288813
Hypophosphataemic osteomalacia	34.00	9.12	17	322102	234	90306094
Hepatorenal syndrome	33.74	9.12	39	322080	2009	90304319
Somatic delusion	33.35	9.12	23	322096	591	90305737
Sinus congestion	33.32	9.12	29	322090	27395	90278933
Crohn's disease	33.32	9.12	61	322058	4790	90301538
Electrocardiogram QT prolonged	33.25	9.12	399	321720	72057	90234271
Faeces discoloured	33.15	9.12	157	321962	21163	90285165
Prescribed overdose	33.06	9.12	509	321610	97116	90209212
Full blood count decreased	33.02	9.12	34	322085	29655	90276673
Blood immunoglobulin A increased	32.98	9.12	31	322088	1252	90305076
Chronic sinusitis	32.97	9.12	22	322097	23780	90282548
Vitamin B1 increased	32.96	9.12	15	322104	165	90306163
Hepatic cytolysis	32.73	9.12	205	321914	30711	90275617
Drug reaction with eosinophilia and systemic symptoms	32.69	9.12	262	321857	42496	90263832
Hepatic ischaemia	32.61	9.12	25	322094	760	90305568
Hyperparathyroidism secondary	32.58	9.12	36	322083	1765	90304563
Urine magnesium decreased	32.50	9.12	7	322112	0	90306328
Muscle spasticity	32.38	9.12	47	322072	35275	90271053
Jaundice	32.20	9.12	212	321907	32305	90274023
Nephrocalcinosis	32.11	9.12	30	322089	1202	90305126
Toxic skin eruption	32.10	9.12	126	321993	15648	90290680
Irritable bowel syndrome	32.09	9.12	965	321154	206483	90099845
Hyperglycaemia	32.00	9.12	299	321820	50671	90255657
Psoriasis	31.98	9.12	353	321766	147401	90158927
Granulocyte count increased	31.87	9.12	33	322086	1501	90304827
Skin candida	31.84	9.12	35	322084	1706	90304622
Product label confusion	31.82	9.12	21	322098	22829	90283499
Purpura	31.68	9.12	120	321999	14658	90291670
Fall	31.60	9.12	1395	320724	480415	89825913
Circulatory collapse	31.46	9.12	173	321946	24731	90281597
Medication error	31.26	9.12	448	321671	84204	90222124
Procedural pain	30.96	9.12	44	322075	33316	90273012
Vasculitis	30.95	9.12	161	321958	22532	90283796
Blood alkaline phosphatase increased	30.67	9.12	283	321836	47796	90258532
Therapeutic response shortened	30.56	9.12	22	322097	22857	90283471
Nasal congestion	30.31	9.12	173	321946	83241	90223087
Erythema multiforme	30.12	9.12	104	322015	12142	90294186
Disease recurrence	29.93	9.12	55	322064	37598	90268730
Finger deformity	29.93	9.12	44	322075	32853	90273475
Bone pain	29.92	9.12	116	322003	61867	90244461
Limb discomfort	29.90	9.12	56	322063	38004	90268324
Haemoptysis	29.89	9.12	212	321907	33108	90273220
Cystitis	29.62	9.12	129	321990	66589	90239739
Sinus disorder	29.50	9.12	48	322071	34399	90271929
Hyperkalaemia	29.49	9.12	357	321762	64607	90241721
Gastritis	29.33	9.12	251	321868	41502	90264826
Pain in extremity	28.81	9.12	1308	320811	449221	89857107
Premature delivery	28.75	9.12	59	322060	38703	90267625
Radiculopathy	28.60	9.12	15	322104	18490	90287838
Panniculitis	28.51	9.12	8	322111	14450	90291878
Basilar artery occlusion	28.44	9.12	14	322105	186	90306142
Pain of skin	28.43	9.12	123	321996	15959	90290369
Female genital tract fistula	28.34	9.12	14	322105	17854	90288474
Personality disorder	28.33	9.12	5	322114	12439	90293889
Swollen joint count	28.20	9.12	81	322038	8572	90297756
Intentional dose omission	28.11	9.12	14	322105	17769	90288559
Fibromyalgia	28.10	9.12	945	321174	205324	90101004
Nasal polyps	28.00	9.12	3	322116	10877	90295451
Progressive multifocal leukoencephalopathy	27.88	9.12	120	321999	15535	90290793
Urine phosphorus decreased	27.86	9.12	6	322113	0	90306328
Gait inability	27.64	9.12	699	321420	145757	90160571
Poisoning deliberate	27.57	9.12	12	322107	16474	90289854
Ulcer haemorrhage	27.54	9.12	174	321945	26147	90280181
Rheumatoid nodule	27.45	9.12	19	322100	20147	90286181
Exposure via skin contact	27.43	9.12	3	322116	10702	90295626
Injection site warmth	27.37	9.12	14	322105	17501	90288827
Back disorder	27.16	9.12	170	321949	25461	90280867
Hyperchlorhydria	27.13	9.12	34	322085	1907	90304421
Oesophagitis	26.81	9.12	127	321992	17122	90289206
Urine potassium decreased	26.75	9.12	7	322112	9	90306319
Sedation	26.70	9.12	85	322034	48086	90258242
Diarrhoea	26.61	9.12	3766	318353	935424	89370904
Complication of device insertion	26.55	9.12	3	322116	10433	90295895
Haematotoxicity	26.53	9.12	6	322113	12529	90293799
Surgery	26.46	9.12	77	322042	44810	90261518
Incorrect dose administered	26.42	9.12	168	321951	78762	90227566
Device issue	26.39	9.12	40	322079	29497	90276831
Sleep disorder due to general medical condition, insomnia type	26.32	9.12	621	321498	128073	90178255
Disseminated intravascular coagulation	26.13	9.12	148	321971	21390	90284938
Injection site mass	26.07	9.12	24	322095	22066	90284262
Coordination abnormal	26.07	9.12	147	321972	21209	90285119
Achlorhydria	25.93	9.12	7	322112	11	90306317
Eye irritation	25.81	9.12	51	322068	33927	90272401
Walking aid user	25.76	9.12	215	321904	35291	90271037
Rheumatoid factor increased	25.69	9.12	37	322082	2374	90303954
Hip fracture	25.69	9.12	49	322070	33028	90273300
Coronary artery disease	25.69	9.12	206	321913	33417	90272911
Breast cancer stage III	25.49	9.12	432	321687	84015	90222313
Deformity	25.41	9.12	6	322113	12164	90294164
Pneumonia	25.25	9.12	1939	320180	636120	89670208
Aspartate aminotransferase	25.13	9.12	21	322098	724	90305604
Gastric polyps	25.12	9.12	53	322066	4619	90301709
Rheumatoid factor positive	25.08	9.12	793	321326	170857	90135471
Hypophosphataemia	25.03	9.12	112	322007	14742	90291586
Ventricular tachycardia	25.02	9.12	162	321957	24546	90281782
Intentional self-injury	25.00	9.12	41	322078	29293	90277035
Oesophageal achalasia	25.00	9.12	20	322099	648	90305680
Post viral fatigue syndrome	24.83	9.12	14	322105	249	90306079
Folliculitis	24.81	9.12	924	321195	203429	90102899
Seasonal allergy	24.80	9.12	27	322092	22956	90283372
Basal cell carcinoma	24.61	9.12	51	322068	33338	90272990
Device malfunction	24.51	9.12	23	322096	20954	90285374
Vomiting	24.42	9.12	3178	318941	785115	89521213
Temperature intolerance	24.41	9.12	96	322023	11934	90294394
Blood albumin abnormal	24.38	9.12	25	322094	1124	90305204
Skin necrosis	24.37	9.12	15	322104	16926	90289402
Herpes zoster	24.29	9.12	217	321902	94427	90211901
Tinnitus	24.19	9.12	247	321872	42855	90263473
Respiratory tract infection	23.99	9.12	118	322001	58960	90247368
Vitamin B12 increased	23.97	9.12	31	322088	1795	90304533
Duodenal ulcer perforation	23.91	9.12	988	321131	220300	90086028
Rheumatic fever	23.86	9.12	713	321406	152408	90153920
Human T-cell lymphotropic virus infection	23.72	9.12	6	322113	6	90306322
Blood parathyroid hormone decreased	23.65	9.12	7	322112	12209	90294119
Condition aggravated	23.37	9.12	1811	320308	593734	89712594
Sensory loss	23.35	9.12	18	322101	18057	90288271
Injection site rash	23.32	9.12	31	322088	24142	90282186
Marasmus	23.32	9.12	21	322098	802	90305526
Hyponatraemic syndrome	23.23	9.12	18	322101	556	90305772
Unevaluable event	23.17	9.12	108	322011	54740	90251588
Pituitary tumour benign	23.13	9.12	33	322086	2099	90304229
Musculoskeletal disorder	23.02	9.12	26	322093	21743	90284585
Infusion related reaction	22.74	9.12	1230	320889	415550	89890778
Nail ridging	22.72	9.12	17	322102	498	90305830
Photodermatosis	22.66	9.12	18	322101	577	90305751
Product use in unapproved indication	22.54	9.12	971	321148	335265	89971063
Renal tubular acidosis	22.47	9.12	34	322085	2281	90304047
Eosinophilia	22.45	9.12	176	321943	28357	90277971
Arthropathy	22.25	9.12	1069	321050	365173	89941155
Cough	22.21	9.12	1078	321041	367884	89938444
Erythema dyschromicum perstans	22.16	9.12	9	322110	73	90306255
Skin exfoliation	21.99	9.12	146	321973	67767	90238561
Blood lactic acid	21.97	9.12	10	322109	110	90306218
Bronchitis	21.85	9.12	397	321722	152530	90153798
Neuropathy, ataxia, retinitis pigmentosa syndrome	21.75	9.12	8	322111	48	90306280
Product preparation error	21.54	9.12	5	322114	10256	90296072
Acne	21.47	9.12	43	322076	28464	90277864
Carbuncle	21.44	9.12	26	322093	1410	90304918
Metastases to bone	21.41	9.12	36	322083	25469	90280859
Muscle relaxant therapy	21.34	9.12	11	322108	162	90306166
Haemorrhage subcutaneous	21.21	9.12	41	322078	3355	90302973
Hypoglycaemic coma	21.05	9.12	38	322081	2952	90303376
Hypoglobulinaemia	20.99	9.12	11	322108	168	90306160
Anaphylactic reaction	20.96	9.12	432	321687	87092	90219236
Enthesopathy	20.93	9.12	4	322115	9400	90296928
Blood alkaline phosphatase abnormal	20.80	9.12	25	322094	1343	90304985
Musculoskeletal toxicity	20.78	9.12	17	322102	569	90305759
Joint injury	20.77	9.12	54	322065	32610	90273718
Maternal exposure timing unspecified	20.72	9.12	144	321975	22339	90283989
Blood pressure systolic increased	20.66	9.12	122	321997	58223	90248105
Rectal ulcer	20.56	9.12	26	322093	1472	90304856
Wrong patient received product	20.53	9.12	41	322078	3436	90302892
Weight increased	20.52	9.12	1246	320873	416681	89889647
Oesophageal mucosal tear	20.40	9.12	6	322113	15	90306313
Renal tubular disorder	20.37	9.12	39	322080	3168	90303160
Chills	20.34	9.12	338	321781	131643	90174685
Fear of injection	20.33	9.12	3	322116	8512	90297816
Secretion discharge	20.32	9.12	16	322103	15880	90290448
Altered state of consciousness	20.31	9.12	186	321933	31346	90274982
Osteoarthritis	20.26	9.12	870	321249	194860	90111468
Dermatitis exfoliative	20.20	9.12	54	322065	5482	90300846
Face oedema	20.12	9.12	147	321972	23171	90283157
Chest wall mass	20.03	9.12	17	322102	599	90305729
Renal cyst	19.87	9.12	95	322024	12855	90293473
Therapy non-responder	19.82	9.12	631	321488	136073	90170255
Dysphagia	19.77	9.12	531	321588	111747	90194581
Endocarditis enterococcal	19.73	9.12	12	322107	247	90306081
Blood uric acid increased	19.45	9.12	66	322053	7638	90298690
Anxiety	19.28	9.12	1313	320806	308459	89997869
Blood pressure abnormal	19.15	9.12	25	322094	19620	90286708
Gastric dysplasia	19.13	9.12	6	322113	20	90306308
Excessive eye blinking	19.12	9.12	24	322095	1348	90304980
Laryngeal pain	19.12	9.12	46	322073	4376	90301952
Pancreatitis acute	18.97	9.12	186	321933	31929	90274399
Malaise	18.95	9.12	2369	319750	583617	89722711
Diplopia	18.81	9.12	170	321949	28544	90277784
Sinusitis	18.81	9.12	1012	321107	342076	89964252
Upper gastrointestinal haemorrhage	18.78	9.12	143	321976	22833	90283495
Carcinoid tumour of the stomach	18.67	9.12	10	322109	160	90306168
Femoral neck fracture	18.65	9.12	79	322040	10154	90296174
Creatinine renal clearance decreased	18.47	9.12	24	322095	18875	90287453
Loose tooth	18.45	9.12	41	322078	3702	90302626
Dysphonia	18.41	9.12	321	321798	62763	90243565
Oropharyngeal pain	18.41	9.12	293	321826	114894	90191434
Arterial intramural haematoma	18.34	9.12	10	322109	166	90306162
Oropharyngeal oedema	18.16	9.12	13	322106	355	90305973
Muscle tension dysphonia	18.15	9.12	12	322107	287	90306041
Hypocalciuria	18.10	9.12	5	322114	9	90306319
Adrenal insufficiency	18.02	9.12	174	321945	29747	90276581
Hypervolaemia	18.02	9.12	58	322061	32699	90273629
Hospice care	18.00	9.12	6	322113	9698	90296630
Carotid artery thrombosis	17.99	9.12	5	322114	9087	90297241
Cardiotoxicity	17.95	9.12	9	322110	11380	90294948
Enterochromaffin cell hyperplasia	17.88	9.12	7	322112	51	90306277
Blood sodium decreased	17.84	9.12	163	321956	27450	90278878
Drug dose omission by device	17.83	9.12	7	322112	10224	90296104
Anticoagulation drug level abnormal	17.80	9.12	9	322110	127	90306201
Deep vein thrombosis	17.79	9.12	439	321680	91181	90215147
Restlessness	17.79	9.12	66	322053	35654	90270674
Trisomy 21	17.75	9.12	14	322105	444	90305884
Rapid eye movement sleep behaviour disorder	17.64	9.12	13	322106	372	90305956
Cerebral haemorrhage	17.58	9.12	194	321925	34328	90272000
Cardiac disorder	17.55	9.12	124	321995	56748	90249580
Scan abnormal	17.55	9.12	16	322103	621	90305707
Injection site urticaria	17.48	9.12	23	322096	17988	90288340
Polyneuropathy	17.47	9.12	26	322093	19315	90287013
Deja vu	17.43	9.12	9	322110	133	90306195
Oral herpes	17.32	9.12	61	322058	33463	90272865
Palpitations	17.26	9.12	621	321498	136107	90170221
Migraine	17.26	9.12	835	321284	189557	90116771
Chromaturia	17.16	9.12	122	321997	19065	90287263
Activated partial thromboplastin time prolonged	17.15	9.12	64	322055	7761	90298567
Anal prolapse	17.12	9.12	8	322111	94	90306234
Sneezing	17.05	9.12	52	322067	29817	90276511
Iron deficiency anaemia	17.01	9.12	143	321976	23519	90282809
Genital ulceration	16.96	9.12	20	322099	1053	90305275
Pathogen resistance	16.94	9.12	4	322115	8111	90298217
Pneumonia bacterial	16.93	9.12	90	322029	12700	90293628
Stillbirth	16.93	9.12	3	322116	7440	90298888
Urine output decreased	16.90	9.12	89	322030	12514	90293814
Dopamine transporter scintigraphy abnormal	16.82	9.12	8	322111	98	90306230
Vaginal discharge	16.78	9.12	27	322092	19437	90286891
Blood calcium increased	16.76	9.12	86	322033	11972	90294356
Product administration interrupted	16.70	9.12	12	322107	12480	90293848
Schizencephaly	16.66	9.12	12	322107	331	90305997
Thrombosis	16.65	9.12	173	321946	73078	90233250
Aplastic anaemia	16.64	9.12	92	322027	13177	90293151
Breast cancer female	16.61	9.12	17	322102	14869	90291459
Impaired quality of life	16.51	9.12	36	322083	23108	90283220
Cerebral haemorrhage foetal	16.51	9.12	12	322107	336	90305992
Cataract	16.50	9.12	170	321949	71922	90234406
Stoma site haemorrhage	16.45	9.12	22	322097	1316	90305012
Renal atrophy	16.34	9.12	26	322093	1822	90304506
Laryngotracheal oedema	16.31	9.12	6	322113	36	90306292
Swelling	16.31	9.12	1275	320844	417783	89888545
Nodule	16.30	9.12	45	322074	26641	90279687
Palatal ulcer	16.27	9.12	10	322109	210	90306118
Flushing	16.26	9.12	219	321900	88272	90218056
Upper respiratory tract infection	16.24	9.12	340	321779	127978	90178350
Endoscopic retrograde cholangiopancreatography	16.23	9.12	10	322109	211	90306117
Oligohydramnios	16.16	9.12	3	322116	7198	90299130
Multiple allergies	16.12	9.12	18	322101	15128	90291200
Blister	16.07	9.12	1082	321037	253916	90052412
Dermatitis bullous	16.06	9.12	76	322043	10240	90296088
Hypersensitivity pneumonitis	15.93	9.12	40	322079	3908	90302420
Eosinophilic pneumonia chronic	15.82	9.12	10	322109	221	90306107
Uveitis	15.75	9.12	20	322099	15883	90290445
Gestational diabetes	15.74	9.12	9	322110	10573	90295755
Psoriatic arthropathy	15.68	9.12	976	321143	227359	90078969
Injection site haemorrhage	15.67	9.12	50	322069	28268	90278060
Non-economic loss	15.65	9.12	5	322114	18	90306310
Leukocytosis	15.60	9.12	57	322062	30933	90275395
Pre-eclampsia	15.59	9.12	10	322109	11038	90295290
Hypoxic-ischaemic encephalopathy	15.51	9.12	44	322075	4624	90301704
Helicobacter infection	15.45	9.12	969	321150	225881	90080447
Heart rate decreased	15.39	9.12	119	322000	53386	90252942
Insurance issue	15.35	9.12	10	322109	10948	90295380
Gallbladder injury	15.34	9.12	21	322098	1285	90305043
Gastrointestinal motility disorder	15.22	9.12	52	322067	6039	90300289
Hypocholesterolaemia	15.20	9.12	54	322065	6395	90299933
Gangrene	15.18	9.12	14	322105	12862	90293466
Asthenia	15.14	9.12	2141	319978	531610	89774718
Contusion	15.13	9.12	1062	321057	250154	90056174
Rash	15.05	9.12	2544	319575	793556	89512772
Dehydration	15.03	9.12	840	321279	193607	90112721
Pressure of speech	14.99	9.12	16	322103	754	90305574
Biliary sepsis	14.96	9.12	18	322101	968	90305360
Monoclonal immunoglobulin present	14.96	9.12	27	322092	2097	90304231
Pemphigus	14.91	9.12	981	321138	325883	89980445
Transplant rejection	14.89	9.12	14	322105	12744	90293584
Narrow anterior chamber angle	14.85	9.12	6	322113	48	90306280
Infusion site streaking	14.74	9.12	14	322105	573	90305755
Enteritis infectious	14.72	9.12	29	322090	2406	90303922
Red cell distribution width increased	14.72	9.12	13	322106	12194	90294134
Haematochezia	14.72	9.12	171	321948	70742	90235586
Maternal exposure before pregnancy	14.70	9.12	11	322108	11202	90295126
Infusion site pain	14.67	9.12	30	322089	19708	90286620
Synovitis	14.65	9.12	992	321127	328760	89977568
Adjustment disorder	14.63	9.12	8	322111	9634	90296694
Joint effusion	14.62	9.12	30	322089	19680	90286648
Sarcoidosis	14.60	9.12	10	322109	10663	90295665
Drug hypersensitivity	14.58	9.12	1434	320685	462175	89844153
Vascular skin disorder	14.55	9.12	4	322115	7	90306321
Central nervous system lesion	14.54	9.12	12	322107	11634	90294694
Tachypnoea	14.51	9.12	34	322085	21275	90285053
Metastases to liver	14.49	9.12	53	322066	28754	90277574
Blood iron decreased	14.48	9.12	26	322093	17933	90288395
Single functional kidney	14.47	9.12	11	322108	330	90305998
Multiple fractures	14.42	9.12	8	322111	9554	90296774
Hypophagia	14.40	9.12	193	321926	35744	90270584
Dactylitis	14.35	9.12	38	322081	3835	90302493
Mitral valve replacement	14.32	9.12	13	322106	502	90305826
Neutrophil count decreased	14.26	9.12	344	321775	71188	90235140
Device use error	14.23	9.12	4	322115	7217	90299111
Paramnesia	14.21	9.12	4	322115	8	90306320
Poisoning	14.19	9.12	20	322099	15197	90291131
Blood urea increased	14.18	9.12	168	321951	30245	90276083
Hypoacusis	14.17	9.12	51	322068	27799	90278529
Hyperprolactinaemia	14.12	9.12	47	322072	5386	90300942
Hiatus hernia	14.07	9.12	145	321974	25216	90281112
Drug use disorder	14.07	9.12	6	322113	8337	90297991
Acute respiratory failure	14.03	9.12	92	322027	42826	90263502
Caesarean section	14.01	9.12	28	322091	18549	90287779
Skin wrinkling	13.97	9.12	21	322098	1401	90304927
Joint noise	13.96	9.12	46	322073	5244	90301084
Respiratory syncytial virus test positive	13.95	9.12	18	322101	1040	90305288
Urine output	13.93	9.12	3	322116	0	90306328
Neurologic neglect syndrome	13.93	9.12	7	322112	8840	90297488
Oesophageal carcinoma recurrent	13.88	9.12	5	322114	28	90306300
Gallbladder disorder	13.88	9.12	119	322000	19684	90286644
Hypothalamo-pituitary disorder	13.83	9.12	27	322092	2225	90304103
Human herpesvirus 6 infection reactivation	13.83	9.12	14	322105	620	90305708
Neck pain	13.83	9.12	304	321815	113659	90192669
Hepatic enzyme increased	13.81	9.12	1099	321020	359637	89946691
CSF test abnormal	13.79	9.12	13	322106	527	90305801
Oral mucosal discolouration	13.79	9.12	11	322108	355	90305973
Bradycardia	13.76	9.12	393	321726	83454	90222874
Abdominal discomfort	13.71	9.12	1486	320633	475842	89830486
Retinitis	13.59	9.12	202	321917	38256	90268072
Spleen congestion	13.59	9.12	7	322112	103	90306225
Skin irritation	13.58	9.12	17	322102	13586	90292742
Labyrinthitis	13.57	9.12	30	322089	2699	90303629
Skin fissures	13.54	9.12	34	322085	20775	90285553
Throat clearing	13.51	9.12	37	322082	3810	90302518
Upper limb fracture	13.47	9.12	36	322083	21542	90284786
Nightmare	13.41	9.12	127	321992	21598	90284730
Gastric ulcer	13.41	9.12	153	321966	27295	90279033
Lactic acidosis	13.40	9.12	253	321866	50210	90256118
Lupus-like syndrome	13.35	9.12	246	321873	48600	90257728
Cholecystitis	13.34	9.12	105	322014	16935	90289393
SARS-CoV-2 test positive	13.24	9.12	12	322107	11116	90295212
Breast cancer stage I	13.19	9.12	9	322110	9615	90296713
Concussion	13.15	9.12	12	322107	11079	90295249
Pneumococcal infection	13.11	9.12	19	322100	1226	90305102
Palmar erythema	13.09	9.12	24	322095	1887	90304441
Metastases to lung	13.03	9.12	23	322096	15968	90290360
Dizziness	12.97	9.12	2331	319788	586953	89719375
Bile duct stone	12.95	9.12	38	322081	4069	90302259
Renal haemangioma	12.94	9.12	5	322114	35	90306293
Foot operation	12.91	9.12	8	322111	8993	90297335
Drug effective for unapproved indication	12.87	9.12	6	322113	7912	90298416
Electrocardiogram QRS complex prolonged	12.85	9.12	5	322114	7343	90298985
Urine calcium/creatinine ratio increased	12.85	9.12	7	322112	116	90306212
Middle insomnia	12.85	9.12	25	322094	16726	90289602
Intestinal ischaemia	12.80	9.12	64	322055	8819	90297509
Gastrointestinal toxicity	12.78	9.12	9	322110	9458	90296870
Pharyngotonsillitis	12.77	9.12	8	322111	174	90306154
Cardioactive drug level increased	12.76	9.12	27	322092	2357	90303971
Abnormal loss of weight	12.69	9.12	53	322066	6770	90299558
Flashback	12.69	9.12	10	322109	317	90306011
Prothrombin time ratio increased	12.64	9.12	7	322112	120	90306208
Dermatitis atopic	12.61	9.12	42	322077	23430	90282898
Therapeutic response unexpected	12.56	9.12	38	322081	21842	90284486
Scratch	12.52	9.12	10	322109	9856	90296472
Septic shock	12.49	9.12	217	321902	83943	90222385
Acute myeloid leukaemia	12.46	9.12	35	322084	20605	90285723
Documented hypersensitivity to administered product	12.45	9.12	14	322105	700	90305628
Oropharyngeal swelling	12.43	9.12	16	322103	922	90305406
Gastrointestinal haemorrhage	12.41	9.12	414	321705	89834	90216494
Renal function test abnormal	12.40	9.12	5	322114	7186	90299142
Protein-losing gastroenteropathy	12.39	9.12	10	322109	328	90306000
Urinary straining	12.37	9.12	5	322114	40	90306288
Nasal oedema	12.34	9.12	4	322115	6580	90299748
Chronic fatigue syndrome	12.32	9.12	21	322098	1558	90304770
Neutrophil count	12.28	9.12	11	322108	417	90305911
Acute coronary syndrome	12.27	9.12	73	322046	10740	90295588
Biopsy muscle abnormal	12.27	9.12	5	322114	41	90306287
Vulvovaginal candidiasis	12.22	9.12	36	322083	3864	90302464
Pneumonia aspiration	12.19	9.12	209	321910	40731	90265597
Device dependence	12.19	9.12	4	322115	16	90306312
Pneumocystis jirovecii pneumonia	12.19	9.12	124	321995	21492	90284836
Affect lability	12.16	9.12	29	322090	18034	90288294
Mouth swelling	12.15	9.12	46	322073	5616	90300712
Nausea	12.12	9.12	3643	318476	1106673	89199655
Depression	12.11	9.12	1233	320886	299368	90006960
Rales	12.11	9.12	97	322022	15730	90290598
Unintended pregnancy	12.09	9.12	6	322113	7631	90298697
Bronchiectasis	12.07	9.12	127	321992	22203	90284125
Muscle spasms	12.07	9.12	1046	321073	250837	90055491
Blindness	12.05	9.12	146	321973	26422	90279906
Picornavirus infection	12.04	9.12	6	322113	82	90306246
Enterocolitis	12.02	9.12	71	322048	10419	90295909
Subendocardial ischaemia	11.97	9.12	6	322113	83	90306245
Weight fluctuation	11.97	9.12	115	322004	19634	90286694
Hepatic cirrhosis	11.96	9.12	302	321817	62951	90243377
Hepatic enzyme	11.96	9.12	44	322075	5300	90301028
Toxic epidermal necrolysis	11.94	9.12	172	321947	32356	90273972
Aspartate aminotransferase abnormal	11.93	9.12	28	322091	2621	90303707
Neoplasm malignant	11.91	9.12	71	322048	33809	90272519
Mediastinitis	11.91	9.12	10	322109	347	90305981
Influenza like illness	11.91	9.12	208	321911	80403	90225925
Haemodialysis	11.89	9.12	62	322057	8685	90297643
Multiple drug therapy	11.88	9.12	5	322114	7004	90299324
Drug level below therapeutic	11.88	9.12	3	322116	5811	90300517
Systemic lupus erythematosus	11.85	9.12	1116	321003	360780	89945548
Cerebral fungal infection	11.84	9.12	9	322110	270	90306058
Catarrh	11.80	9.12	21	322098	1613	90304715
Pancreatic carcinoma recurrent	11.78	9.12	6	322113	86	90306242
Breath sounds abnormal	11.77	9.12	23	322096	15363	90290965
Overweight	11.75	9.12	47	322072	5887	90300441
Ulcer	11.73	9.12	173	321946	32709	90273619
Tooth hypoplasia	11.72	9.12	6	322113	87	90306241
Chronic kidney disease-mineral and bone disorder	11.64	9.12	7	322112	141	90306187
Syncope	11.64	9.12	580	321539	132083	90174245
Thyroid disorder	11.62	9.12	29	322090	17756	90288572
Respiratory arrest	11.61	9.12	70	322049	33241	90273087
Ovarian fibroma	11.49	9.12	6	322113	91	90306237
Cervix inflammation	11.48	9.12	4	322115	20	90306308
Drug interaction	11.43	9.12	1136	320983	275317	90031011
Genitourinary symptom	11.43	9.12	7	322112	146	90306182
Oesophageal food impaction	11.42	9.12	9	322110	285	90306043
Lacunar infarction	11.38	9.12	32	322087	3345	90302983
Complication of device removal	11.37	9.12	4	322115	6251	90300077
Pregnancy	11.37	9.12	295	321824	61752	90244576
Sensitivity to weather change	11.36	9.12	9	322110	8905	90297423
Amenorrhoea	11.34	9.12	15	322104	11707	90294621
Epstein-Barr virus infection	11.33	9.12	12	322107	10332	90295996
Degenerative mitral valve disease	11.32	9.12	4	322115	21	90306307
Ocular hyperaemia	11.28	9.12	72	322047	33726	90272602
Skin oedema	11.27	9.12	17	322102	1137	90305191
Body temperature increased	11.25	9.12	103	322016	44607	90261721
Gastric cancer	11.25	9.12	42	322077	5094	90301234
Skin toxicity	11.23	9.12	5	322114	6774	90299554
Dyspnoea exertional	11.18	9.12	185	321934	72103	90234225
Perforation	11.16	9.12	23	322096	1971	90304357
Poor venous access	11.14	9.12	34	322085	19493	90286835
Pneumonia viral	11.13	9.12	9	322110	8814	90297514
Azotaemia	11.11	9.12	43	322076	5305	90301023
Vaginal cellulitis	11.09	9.12	6	322113	98	90306230
Noninfective gingivitis	11.09	9.12	24	322095	2129	90304199
Hypochloraemia	11.04	9.12	27	322092	2595	90303733
Drug effect less than expected	11.03	9.12	4	322115	6134	90300194
Multiple injuries	11.02	9.12	22	322097	1843	90304485
Hypercholesterolaemia	11.01	9.12	451	321668	100441	90205887
Gallbladder hypofunction	10.98	9.12	11	322108	481	90305847
Spinal operation	10.98	9.12	12	322107	10184	90296144
Immune thrombocytopenia	10.93	9.12	83	322036	13243	90293085
Pharyngeal inflammation	10.91	9.12	16	322103	1044	90305284
Fibrosis	10.89	9.12	46	322073	5906	90300422
Post cardiac arrest syndrome	10.87	9.12	4	322115	24	90306304
Spinal pain	10.86	9.12	25	322094	15742	90290586
Hemiplegia	10.83	9.12	26	322093	16134	90290194
Suicidal ideation	10.78	9.12	191	321928	73664	90232664
Aortic valve replacement	10.76	9.12	15	322104	934	90305394
Dyslalia	10.72	9.12	13	322106	705	90305623
Dialysis	10.70	9.12	73	322046	11256	90295072
Gastroduodenal ulcer	10.68	9.12	10	322109	402	90305926
Large intestine perforation	10.66	9.12	65	322054	9647	90296681
Bronchogenic cyst	10.66	9.12	3	322116	6	90306322
Stevens-Johnson syndrome	10.65	9.12	155	321964	29221	90277107
Rash papulosquamous	10.63	9.12	6	322113	107	90306221
Colon cancer	10.62	9.12	71	322048	10873	90295455
Drug dependence	10.56	9.12	61	322058	29266	90277062
Cholangitis	10.53	9.12	52	322067	7130	90299198
Device leakage	10.49	9.12	12	322107	9979	90296349
Vulval haemorrhage	10.48	9.12	4	322115	27	90306301
Uterine perforation	10.44	9.12	7	322112	7547	90298781
Immune reconstitution inflammatory syndrome	10.40	9.12	6	322113	7013	90299315
Memory impairment	10.39	9.12	825	321294	196419	90109909
Neuroleptic malignant syndrome	10.35	9.12	24	322095	15072	90291256
Blood test abnormal	10.33	9.12	117	322002	20835	90285493
Aortic valve calcification	10.32	9.12	12	322107	622	90305706
Tuberculosis	10.27	9.12	18	322101	12531	90293797
Blood bilirubin abnormal	10.24	9.12	22	322097	1942	90304386
Parosmia	10.23	9.12	51	322068	7018	90299310
Coma	10.23	9.12	189	321930	72443	90233885
Lip oedema	10.22	9.12	38	322081	4601	90301727
Morbid thoughts	10.21	9.12	13	322106	741	90305587
Myocardial ischaemia	10.21	9.12	84	322035	13730	90292598
Respiration abnormal	10.20	9.12	8	322111	7955	90298373
Rash papular	10.19	9.12	114	322005	20241	90286087
Bleeding time prolonged	10.19	9.12	12	322107	631	90305697
Genital pain	10.16	9.12	13	322106	745	90305583
Vitamin B12 deficiency	10.13	9.12	53	322066	7433	90298895
Osteitis	10.13	9.12	33	322086	3740	90302588
Nasal mucosal erosion	10.12	9.12	5	322114	67	90306261
Dilatation atrial	10.11	9.12	22	322097	1959	90304369
Ocular discomfort	10.09	9.12	5	322114	6365	90299963
Feeling jittery	10.09	9.12	25	322094	15346	90290982
Urinary tract infection	10.07	9.12	942	321177	304690	90001638
Cyst	10.06	9.12	28	322091	16533	90289795
Lymphadenopathy	10.04	9.12	109	322010	45666	90260662
Gambling	10.03	9.12	8	322111	258	90306070
Tuberculous pleurisy	10.02	9.12	10	322109	435	90305893
Superinfection	10.01	9.12	29	322090	3083	90303245
Motor dysfunction	9.93	9.12	35	322084	19195	90287133
Skin burning sensation	9.92	9.12	36	322083	19575	90286753
Duodenal ulcer	9.90	9.12	63	322056	9489	90296839
Blood creatinine increased	9.90	9.12	448	321671	100938	90205390
Aortic aneurysm rupture	9.88	9.12	11	322108	544	90305784
Incorrect dose administered by device	9.88	9.12	4	322115	5733	90300595
Product adhesion issue	9.86	9.12	3	322116	5139	90301189
Ileus	9.86	9.12	96	322023	16450	90289878
Thyroid cancer	9.85	9.12	5	322114	6279	90300049
Disturbance in attention	9.83	9.12	228	321891	46881	90259447
Hyperacusis	9.83	9.12	27	322092	2784	90303544
Underdose	9.81	9.12	134	321985	53883	90252445
Blood triglycerides increased	9.81	9.12	83	322036	13678	90292650
Pericarditis	9.75	9.12	1100	321019	269051	90037277
Ankylosing spondylitis	9.73	9.12	20	322099	13113	90293215
Renal cyst haemorrhage	9.68	9.12	5	322114	74	90306254
Burn oral cavity	9.66	9.12	7	322112	195	90306133
Paranasal sinus discomfort	9.65	9.12	5	322114	6205	90300123
Genital haemorrhage	9.64	9.12	10	322109	8692	90297636
Pregnancy with contraceptive device	9.63	9.12	3	322116	5063	90301265
Solar lentigo	9.62	9.12	16	322103	1164	90305164
Dysuria	9.60	9.12	195	321924	39206	90267122
Femoral hernia	9.59	9.12	4	322115	35	90306293
Blood pressure fluctuation	9.53	9.12	130	321989	52283	90254045
Embolic stroke	9.51	9.12	34	322085	4038	90302290
Gastrointestinal amyloidosis	9.50	9.12	5	322114	77	90306251
Atypical fracture	9.50	9.12	14	322105	917	90305411
Vision blurred	9.50	9.12	309	321810	109984	90196344
Clonus	9.42	9.12	43	322076	5707	90300621
Breast pain	9.41	9.12	14	322105	10404	90295924
Dry eye	9.37	9.12	147	321972	57784	90248544
Gastroenteritis	9.36	9.12	151	321968	29078	90277250
Myocardial necrosis	9.36	9.12	7	322112	205	90306123
Second primary malignancy	9.32	9.12	14	322105	10364	90295964
Aortitis	9.30	9.12	17	322102	1333	90304995
Parkinsonian gait	9.30	9.12	11	322108	581	90305747
Gastrointestinal stoma output decreased	9.24	9.12	6	322113	139	90306189
Drug specific antibody present	9.24	9.12	4	322115	5510	90300818
Product quality issue	9.22	9.12	213	321906	79112	90227216
Orthostatic hypotension	9.22	9.12	204	321915	41623	90264705
Colitis ulcerative	9.21	9.12	280	321839	59986	90246342
Uraemic encephalopathy	9.21	9.12	8	322111	291	90306037
Pyelonephritis acute	9.19	9.12	41	322078	5391	90300937
Phyllodes tumour	9.17	9.12	5	322114	83	90306245
Subdural haematoma	9.16	9.12	95	322024	16550	90289778
Pleurisy viral	9.14	9.12	3	322116	12	90306316
Obstructive nephropathy	9.14	9.12	3	322116	12	90306316
Akathisia	9.14	9.12	16	322103	11143	90295185
Cystitis noninfective	9.13	9.12	17	322102	1352	90304976
Amniotic fluid index decreased	9.12	9.12	4	322115	40	90306288
Catheter site erythema	9.12	9.12	3	322116	4891	90301437

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	593.90	10.22	979	166312	629218	41824826
Chronic kidney disease	471.90	10.22	741	166550	46500	42407544
Death	352.74	10.22	836	166455	470349	41983695
Colitis microscopic	299.42	10.22	174	167117	2959	42451085
Completed suicide	240.26	10.22	44	167247	96421	42357623
Hyponatraemia	236.08	10.22	904	166387	100558	42353486
End stage renal disease	220.96	10.22	298	166993	16260	42437784
Toxicity to various agents	206.98	10.22	364	166927	228772	42225272
Interstitial lung disease	203.36	10.22	724	166567	77738	42376306
Off label use	183.22	10.22	1616	165675	636719	41817325
Drug abuse	165.92	10.22	103	167188	104668	42349376
Product dose omission issue	164.48	10.22	219	167072	154146	42299898
Appendicolith	152.55	10.22	224	167067	13232	42440812
Renal injury	145.88	10.22	209	167082	12071	42441973
Treatment failure	142.71	10.22	35	167256	62589	42391455
Drug dispensed to wrong patient	135.16	10.22	57	167234	460	42453584
Lip swelling	130.23	10.22	253	167038	18800	42435244
Appendicitis	119.88	10.22	256	167035	20357	42433687
Cardiospasm	119.41	10.22	81	167210	1826	42452218
Lower respiratory tract infection	113.41	10.22	388	166903	40818	42413226
Acute kidney injury	103.62	10.22	2019	165272	365318	42088726
Palmoplantar keratoderma	100.64	10.22	78	167213	2176	42451868
Foetal exposure during pregnancy	99.28	10.22	31	167260	47280	42406764
Pruritus genital	98.03	10.22	82	167209	2557	42451487
Tension headache	96.74	10.22	91	167200	3323	42450721
Cerebral infarction	91.53	10.22	300	166991	30869	42423175
Drug resistance	91.10	10.22	13	167278	34235	42419809
Sleep terror	88.73	10.22	81	167210	2845	42451199
Cholestasis	87.34	10.22	306	166985	32573	42421471
Ventricular fibrillation	84.07	10.22	285	167006	29838	42424206
Disease progression	82.60	10.22	288	167003	143368	42310676
Intentional overdose	80.85	10.22	51	167240	51405	42402639
Stress	80.03	10.22	365	166926	43847	42410197
Nephrogenic anaemia	79.22	10.22	72	167219	2514	42451530
Atrial tachycardia	78.62	10.22	89	167202	4051	42449993
Fatigue	77.42	10.22	1224	166067	434417	42019627
Hepatic function abnormal	77.06	10.22	403	166888	51164	42402880
Immunisation	75.37	10.22	52	167239	1206	42452838
Blood phosphorus increased	72.18	10.22	155	167136	12370	42441674
Facial pain	71.58	10.22	86	167205	4174	42449870
Neutropenic sepsis	70.67	10.22	178	167113	15768	42438276
Suicide attempt	70.64	10.22	47	167244	46053	42407991
Product use in unapproved indication	69.19	10.22	432	166859	184024	42270020
Carotid artery occlusion	67.75	10.22	83	167208	4111	42449933
Subacute cutaneous lupus erythematosus	67.54	10.22	52	167239	1436	42452608
Hospitalisation	67.03	10.22	118	167173	74212	42379832
Venous pressure jugular increased	66.25	10.22	40	167251	732	42453312
Tubulointerstitial nephritis	65.15	10.22	271	167020	31277	42422767
Malaise	65.10	10.22	1182	166109	210974	42243070
Rectal haemorrhage	62.99	10.22	371	166920	49235	42404809
Angioedema	62.80	10.22	331	166960	42146	42411898
Hypergastrinaemia	62.72	10.22	26	167265	200	42453844
Hypomagnesaemia	62.22	10.22	249	167042	28239	42425805
Therapeutic product effect incomplete	60.95	10.22	116	167175	70823	42383221
Agranulocytosis	60.91	10.22	260	167031	30352	42423692
Drug ineffective for unapproved indication	60.67	10.22	55	167236	46108	42407936
Antimicrobial susceptibility test resistant	60.36	10.22	30	167261	366	42453678
Minimum inhibitory concentration	58.57	10.22	23	167268	151	42453893
Injection site pain	57.50	10.22	86	167205	57712	42396332
Abdominal distension	56.66	10.22	478	166813	71257	42382787
Hypertensive nephropathy	56.58	10.22	31	167260	468	42453576
Eosinophil count decreased	56.53	10.22	70	167221	3506	42450538
Palpitations	56.39	10.22	367	166924	50430	42403614
Transient ischaemic attack	56.26	10.22	272	167019	33467	42420577
Ascites	56.07	10.22	398	166893	56280	42397764
Weight increased	55.84	10.22	226	167065	107757	42346287
Anosmia	55.56	10.22	84	167207	5092	42448952
Blood uric acid increased	55.28	10.22	160	167131	15387	42438657
Toxic epidermal necrolysis	53.84	10.22	228	167063	26522	42427522
Wrong patient received product	53.24	10.22	68	167223	3515	42450529
Liver function test abnormal	52.48	10.22	259	167032	32132	42421912
Tinnitus	52.43	10.22	239	167052	28699	42425345
Adrenal suppression	51.12	10.22	37	167254	928	42453116
Therapy partial responder	50.10	10.22	9	167282	20012	42434032
Confusional state	49.36	10.22	928	166363	166669	42287375
Haematemesis	49.31	10.22	242	167049	29957	42424087
Gingival disorder	48.56	10.22	44	167247	1530	42452514
Myasthenia gravis	47.98	10.22	156	167135	15981	42438063
Nasopharyngitis	47.83	10.22	169	167122	83827	42370217
Gastric polyps	47.23	10.22	45	167246	1670	42452374
Pain of skin	46.57	10.22	100	167191	7980	42446064
Bronchiectasis	46.38	10.22	166	167125	17853	42436191
Subarachnoid haemorrhage	45.85	10.22	143	167148	14329	42439715
Aplastic anaemia	45.54	10.22	129	167162	12255	42441789
Hypoparathyroidism secondary	45.16	10.22	20	167271	184	42453860
Hepatic cytolysis	43.74	10.22	215	167076	26629	42427415
Therapeutic response delayed	43.74	10.22	30	167261	689	42453355
Central nervous system mass	43.65	10.22	32	167259	819	42453225
Swollen tongue	43.53	10.22	182	167109	21049	42432995
Wall motion score index abnormal	43.52	10.22	32	167259	823	42453221
Abdominal pain	42.87	10.22	1014	166277	189457	42264587
Blood cholesterol increased	42.74	10.22	213	167078	26528	42427516
Therapy non-responder	42.63	10.22	91	167200	53268	42400776
Eosinophilia	42.37	10.22	247	167044	32652	42421392
Airway remodelling	42.05	10.22	32	167259	868	42453176
Melaena	41.82	10.22	278	167013	38468	42415576
Muscle twitching	41.66	10.22	121	167170	11659	42442385
Terminal insomnia	41.46	10.22	32	167259	887	42453157
Analgesic therapy	41.41	10.22	84	167207	6440	42447604
Cardiac murmur	41.18	10.22	127	167164	12648	42441396
Renal impairment	40.65	10.22	633	166658	109595	42344449
Protein-losing gastroenteropathy	40.64	10.22	24	167267	421	42453623
Rash papular	40.51	10.22	120	167171	11691	42442353
Pericarditis	40.00	10.22	130	167161	13314	42440730
Accidental exposure to product	39.94	10.22	15	167276	20378	42433666
Gastrointestinal polyp haemorrhage	39.90	10.22	25	167266	490	42453554
Atopy	39.79	10.22	32	167259	943	42453101
Sleep disorder therapy	39.36	10.22	85	167206	6809	42447235
Therapeutic response shortened	38.86	10.22	4	167287	13550	42440494
Therapeutic product effect decreased	38.22	10.22	59	167232	39091	42414953
Vomiting	38.15	10.22	1443	165848	288280	42165764
Cardiac septal defect	38.10	10.22	31	167260	929	42453115
Cardiogenic shock	37.44	10.22	254	167037	35386	42418658
Haemorrhage subcutaneous	37.41	10.22	49	167242	2597	42451447
Catarrh	36.72	10.22	76	167215	5910	42448134
Migraine	36.16	10.22	196	167095	25218	42428826
Gingival pain	35.76	10.22	93	167198	8401	42445643
Occupational dermatitis	35.64	10.22	14	167277	92	42453952
Jaundice	35.43	10.22	245	167046	34344	42419700
Medication error	35.25	10.22	237	167054	32917	42421127
Tetanus	34.11	10.22	12	167279	55	42453989
Eosinophilic myocarditis	34.02	10.22	34	167257	1339	42452705
Hyperphosphataemia	33.64	10.22	120	167171	12884	42441160
Burns second degree	33.48	10.22	74	167217	6022	42448022
Drug dependence	33.31	10.22	39	167252	29055	42424989
Synovitis	33.01	10.22	10	167281	15557	42438487
Hypocalcaemia	32.27	10.22	216	167075	29957	42424087
Device dependence	32.26	10.22	11	167280	45	42453999
Parosmia	32.16	10.22	84	167207	7607	42446437
Chronic kidney disease-mineral and bone disorder	32.13	10.22	21	167270	444	42453600
Poisoning	31.98	10.22	9	167282	14690	42439354
Liver disorder	31.73	10.22	265	167026	39379	42414665
Hepatocellular injury	31.29	10.22	179	167112	23499	42430545
Full blood count abnormal	31.14	10.22	43	167248	29833	42424211
Pancreatitis acute	31.06	10.22	232	167059	33332	42420712
Blood pressure fluctuation	30.88	10.22	36	167255	26872	42427172
Overdose	30.54	10.22	265	167026	104999	42349045
Ventricular tachycardia	30.52	10.22	213	167078	29947	42424097
Nephropathy	30.47	10.22	77	167214	6834	42447210
Drug therapy	30.15	10.22	73	167218	6307	42447737
Amnesia	30.06	10.22	203	167088	28234	42425810
Gait disturbance	29.65	10.22	244	167047	97756	42356288
Diabetic nephropathy	29.51	10.22	41	167250	2300	42451744
Injection site warmth	29.45	10.22	44	167247	2639	42451405
Iron deficiency	29.41	10.22	103	167188	10958	42443086
Activated partial thromboplastin time prolonged	29.29	10.22	132	167159	15771	42438273
Influenza	29.15	10.22	135	167156	62040	42392004
Drug eruption	28.91	10.22	172	167119	22903	42431141
Idiopathic pulmonary fibrosis	28.89	10.22	59	167232	4545	42449499
Therapy interrupted	28.65	10.22	27	167264	22223	42431821
Incorrect dose administered	28.56	10.22	109	167182	52865	42401179
Systemic lupus erythematosus	28.50	10.22	91	167200	9233	42444811
Gastric cancer	28.46	10.22	75	167216	6828	42447216
Hypopnoea	27.91	10.22	81	167210	7801	42446243
Sedation	27.80	10.22	48	167243	30427	42423617
Rash vesicular	27.69	10.22	48	167243	3265	42450779
Steroid dependence	27.68	10.22	73	167218	6649	42447395
Myelosuppression	27.57	10.22	75	167216	40386	42413658
Marasmus	27.48	10.22	25	167266	874	42453170
Hepatitis cholestatic	27.45	10.22	93	167198	9731	42444313
Administration site inflammation	27.40	10.22	10	167281	52	42453992
Haematotoxicity	27.35	10.22	5	167286	10980	42443064
Diplopia	27.12	10.22	154	167137	20162	42433882
Unevaluable event	26.95	10.22	59	167232	34229	42419815
Increased viscosity of upper respiratory secretion	26.83	10.22	17	167274	340	42453704
Infusion related reaction	26.78	10.22	135	167156	60671	42393373
Neuroendocrine tumour	26.62	10.22	25	167266	911	42453133
Pneumonia aspiration	26.48	10.22	307	166984	49771	42404273
Neutrophil count decreased	26.43	10.22	372	166919	63043	42391001
Eosinophilic oesophagitis	26.19	10.22	22	167269	690	42453354
Hypoacusis	26.13	10.22	21	167270	18681	42435363
Therapy cessation	26.11	10.22	25	167266	20425	42433619
Psoriatic arthropathy	25.96	10.22	36	167255	24931	42429113
Aspergillus infection	25.84	10.22	15	167276	15822	42438222
Microangiopathy	25.11	10.22	32	167259	1650	42452394
Rheumatoid arthritis	25.09	10.22	84	167207	42356	42411688
Renal disorder	24.97	10.22	197	167094	28783	42425261
Faecal vomiting	24.67	10.22	21	167270	671	42453373
Tetany	24.38	10.22	26	167265	1106	42452938
Subdural haematoma	24.35	10.22	165	167126	22973	42431071
Product use issue	24.18	10.22	189	167102	76562	42377482
Asthenia	23.98	10.22	881	166410	279912	42174132
Inappropriate schedule of product administration	23.75	10.22	251	167040	95651	42358393
Wrong technique in product usage process	23.45	10.22	87	167204	42548	42411496
Hepatitis acute	23.37	10.22	83	167208	8892	42445152
Occupational exposure to air contaminants	23.21	10.22	12	167279	160	42453884
Drug reaction with eosinophilia and systemic symptoms	23.17	10.22	260	167031	41815	42412229
Pathogen resistance	23.14	10.22	8	167283	11442	42442602
Femoral neck fracture	23.01	10.22	51	167240	4158	42449886
Chest pain	22.85	10.22	713	166578	138817	42315227
Essential thrombocythaemia	22.82	10.22	12	167279	166	42453878
Therapeutic response decreased	22.75	10.22	72	167219	36940	42417104
Neuropathy peripheral	22.69	10.22	273	167018	101580	42352464
Constipation	22.68	10.22	814	166477	161477	42292567
Poisoning deliberate	22.43	10.22	6	167285	10128	42443916
Pneumonia bacterial	22.31	10.22	121	167170	15571	42438473
Melanoderma	21.91	10.22	12	167279	181	42453863
Eosinophil count increased	21.86	10.22	92	167199	10671	42443373
Neurotoxicity	21.81	10.22	37	167254	23614	42430430
Weight decreased	21.64	10.22	636	166655	207312	42246732
Localised infection	21.56	10.22	29	167262	20344	42433700
Hyperchlorhydria	21.50	10.22	19	167272	639	42453405
Dermatitis atopic	21.33	10.22	11	167280	12393	42441651
Prostatic specific antigen increased	21.25	10.22	21	167270	16904	42437140
Hypophosphataemia	21.24	10.22	148	167143	20797	42433247
Aortic stenosis	21.18	10.22	79	167212	8666	42445378
Eosinophilic pneumonia	21.17	10.22	54	167237	4820	42449224
Laboratory test abnormal	21.14	10.22	36	167255	22942	42431102
Dehydration	21.03	10.22	716	166575	141051	42312993
Cystitis escherichia	20.96	10.22	12	167279	198	42453846
Orthostatic hypotension	20.68	10.22	197	167094	30373	42423671
Immune reconstitution inflammatory syndrome	20.65	10.22	7	167284	10136	42443908
No adverse event	20.58	10.22	81	167210	38940	42415104
Disseminated intravascular coagulation	20.51	10.22	167	167124	24627	42429417
Nightmare	20.44	10.22	168	167123	24844	42429200
Thrombotic cerebral infarction	20.44	10.22	16	167275	453	42453591
Hypozincaemia	20.40	10.22	6	167285	13	42454031
Prostate tenderness	20.31	10.22	8	167283	53	42453991
Coma	20.25	10.22	125	167166	53429	42400615
Rash maculo-papular	19.87	10.22	230	167061	37273	42416771
Premature baby	19.75	10.22	38	167253	23115	42430929
Enteritis infectious	19.72	10.22	28	167263	1603	42452441
Device malfunction	19.66	10.22	12	167279	12315	42441729
Rhinitis	19.56	10.22	96	167195	11881	42442163
Oral disorder	19.55	10.22	52	167239	4760	42449284
Ocular myasthenia	19.53	10.22	17	167274	560	42453484
Alcoholic liver disease	19.53	10.22	17	167274	560	42453484
Upper respiratory tract inflammation	19.27	10.22	30	167261	1866	42452178
Hypotension	19.24	10.22	821	166470	256810	42197234
Total lung capacity decreased	19.23	10.22	43	167248	3527	42450517
Incorrect route of product administration	19.20	10.22	162	167129	24143	42429901
Blood magnesium decreased	18.89	10.22	70	167221	7656	42446388
Sinobronchitis	18.80	10.22	5	167286	6	42454038
Gastric varices	18.80	10.22	18	167273	672	42453372
Enterochromaffin cell hyperplasia	18.78	10.22	6	167285	19	42454025
Dry mouth	18.70	10.22	239	167052	39640	42414404
Rebound acid hypersecretion	18.69	10.22	9	167282	102	42453942
Blood alkaline phosphatase increased	18.68	10.22	208	167083	33389	42420655
Hallucination	18.50	10.22	323	166968	57184	42396860
Pelvic pain	18.44	10.22	40	167251	3214	42450830
Cytokine release syndrome	18.40	10.22	101	167190	44426	42409618
Mouth ulceration	18.40	10.22	111	167180	14852	42439192
Alveolitis	18.25	10.22	29	167262	1836	42452208
Paraesthesia oral	18.22	10.22	53	167238	5110	42448934
Oesophagitis	18.05	10.22	112	167179	15135	42438909
Alcohol poisoning	18.00	10.22	68	167223	7506	42446538
Device leakage	17.87	10.22	9	167282	10276	42443768
Failure to anastomose	17.81	10.22	11	167280	210	42453834
Radiation pneumonitis	17.71	10.22	37	167254	2896	42451148
Pseudocellulitis	17.67	10.22	12	167279	271	42453773
Eye pruritus	17.60	10.22	90	167201	11322	42442722
Cholangitis	17.53	10.22	86	167205	10641	42443403
Iron deficiency anaemia	17.51	10.22	99	167192	12940	42441104
Intracranial haematoma	17.45	10.22	16	167275	565	42453479
Post transplant lymphoproliferative disorder	17.38	10.22	7	167284	9113	42444931
Full blood count decreased	17.32	10.22	34	167257	20526	42433518
Blood pressure increased	17.12	10.22	289	167002	101639	42352405
Toxic skin eruption	16.98	10.22	102	167189	13628	42440416
Lung opacity	16.96	10.22	56	167235	5781	42448263
Respiratory depression	16.95	10.22	30	167261	18838	42435206
Vasculitis	16.93	10.22	127	167164	18267	42435777
Akathisia	16.91	10.22	10	167281	10441	42443603
Cardio-respiratory arrest	16.83	10.22	148	167143	58488	42395556
Abdominal pain upper	16.81	10.22	434	166857	82175	42371869
Haemorrhagic cerebral infarction	16.66	10.22	19	167272	872	42453172
Pulmonary thrombosis	16.58	10.22	6	167285	8342	42445702
Miosis	16.52	10.22	17	167274	13429	42440615
Hiatus hernia	16.48	10.22	72	167219	8488	42445556
Multiple sclerosis relapse	16.46	10.22	19	167272	14245	42439799
Impaired work ability	16.36	10.22	92	167199	11999	42442045
Chills	16.36	10.22	265	167026	93801	42360243
Renal failure	16.34	10.22	705	166586	143021	42311023
Genital pain	16.33	10.22	19	167272	891	42453153
Circulatory collapse	16.33	10.22	153	167138	23483	42430561
Erythema multiforme	16.31	10.22	80	167211	9897	42444147
Pain	16.30	10.22	790	166501	244058	42209986
Vasculitic rash	16.08	10.22	20	167271	1006	42453038
Gastrooesophageal reflux disease	15.99	10.22	257	167034	44766	42409278
Adverse event	15.97	10.22	44	167247	23596	42430448
Transplant rejection	15.79	10.22	18	167273	13570	42440474
Hypoaesthesia	15.74	10.22	192	167099	71271	42382773
Hyperlipidaemia	15.74	10.22	141	167150	21375	42432669
Nasal congestion	15.71	10.22	61	167230	29440	42424604
Inappropriate antidiuretic hormone secretion	15.68	10.22	115	167176	16426	42437618
Device issue	15.58	10.22	18	167273	13491	42440553
Delusion	15.56	10.22	21	167270	14713	42439331
Drug intolerance	15.55	10.22	222	167069	80202	42373842
Hospice care	15.48	10.22	7	167284	8506	42445538
Colitis ulcerative	15.45	10.22	164	167127	26011	42428033
Intentional dose omission	15.40	10.22	8	167283	8978	42445066
Acute graft versus host disease in skin	15.33	10.22	5	167286	7419	42446625
Glomerulosclerosis	15.27	10.22	18	167273	856	42453188
Abulia	15.13	10.22	16	167275	674	42453370
Diabetes mellitus	15.08	10.22	325	166966	59762	42394282
Mental status changes	15.06	10.22	100	167191	42015	42412029
Eczema	15.03	10.22	202	167089	33884	42420160
Rash morbilliform	15.01	10.22	43	167248	4110	42449934
Follicular mucinosis	14.95	10.22	5	167286	19	42454025
Renal artery stenosis	14.90	10.22	30	167261	2287	42451757
Cerebral haemorrhage	14.82	10.22	225	167066	38741	42415303
Epstein-Barr virus infection	14.76	10.22	10	167281	9708	42444336
Renal haemangioma	14.75	10.22	5	167286	20	42454024
Treatment noncompliance	14.73	10.22	87	167204	37585	42416459
Platelet count decreased	14.71	10.22	675	166616	137906	42316138
Swelling face	14.60	10.22	169	167122	27385	42426659
Acute graft versus host disease	14.55	10.22	7	167284	8208	42445836
Gastric ulcer haemorrhage	14.55	10.22	55	167236	6072	42447972
Respiratory muscle weakness	14.53	10.22	8	167283	122	42453922
Chronic graft versus host disease	14.46	10.22	3	167288	6022	42448022
Venous thrombosis limb	14.44	10.22	30	167261	2339	42451705
Hypoxia	14.44	10.22	190	167101	69596	42384448
Mucormycosis	14.42	10.22	5	167286	7138	42446906
Enterocolitis	14.41	10.22	77	167214	9852	42444192
Upper gastrointestinal haemorrhage	14.38	10.22	182	167109	30117	42423927
Lymphocyte stimulation test positive	14.32	10.22	15	167276	625	42453419
Duodenal polyp	14.31	10.22	11	167280	303	42453741
Immune thrombocytopenia	14.30	10.22	84	167207	11132	42442912
Nephrosclerosis	14.20	10.22	19	167272	1028	42453016
Diffuse vasculitis	14.11	10.22	7	167284	85	42453959
Barrett's oesophagus	14.11	10.22	12	167279	383	42453661
Mobility decreased	14.09	10.22	81	167210	35225	42418819
Neutrophil count increased	14.08	10.22	129	167162	19675	42434369
Serotonin syndrome	14.04	10.22	53	167238	25792	42428252
Gastrointestinal ulcer	14.03	10.22	26	167265	1864	42452180
Crohn's disease	13.95	10.22	34	167257	2950	42451094
Polyneuropathy	13.94	10.22	33	167258	18628	42435416
Neuralgia	13.90	10.22	158	167133	25489	42428555
Renal atrophy	13.73	10.22	21	167270	1286	42452758
Contraindication to medical treatment	13.58	10.22	17	167274	861	42453183
Ejection fraction decreased	13.55	10.22	43	167248	22044	42432000
Product dose omission in error	13.51	10.22	8	167283	8346	42445698
Renal hypertension	13.44	10.22	10	167281	262	42453782
Gastrostomy tube site complication	13.43	10.22	7	167284	95	42453949
Hypovitaminosis	13.42	10.22	16	167275	770	42453274
BK virus infection	13.39	10.22	9	167282	8775	42445269
Dermatitis acneiform	13.34	10.22	63	167228	7676	42446368
Therapeutic response unexpected	13.31	10.22	15	167276	11366	42442678
Blindness	13.24	10.22	118	167173	17860	42436184
Thalamus haemorrhage	13.22	10.22	19	167272	1100	42452944
Sopor	13.22	10.22	93	167198	13109	42440935
Nephropathy toxic	13.21	10.22	29	167262	16809	42437235
Gastrointestinal infection	13.14	10.22	5	167286	6738	42447306
Periprosthetic fracture	13.03	10.22	9	167282	209	42453835
Neurological symptom	13.01	10.22	12	167279	9979	42444065
Burning feet syndrome	12.93	10.22	7	167284	103	42453941
Heart rate decreased	12.93	10.22	87	167204	36445	42417599
Biliary sepsis	12.89	10.22	17	167274	907	42453137
Infection	12.86	10.22	338	166953	111730	42342314
Anal spasm	12.85	10.22	8	167283	155	42453889
Gastritis	12.74	10.22	147	167144	23800	42430244
Anticoagulant therapy	12.73	10.22	43	167248	4492	42449552
Procedural failure	12.70	10.22	6	167285	65	42453979
Oesophagogastric fundoplasty	12.68	10.22	4	167287	12	42454032
Purpura	12.67	10.22	85	167206	11794	42442250
Retinal vascular occlusion	12.63	10.22	9	167282	220	42453824
Septic embolus	12.60	10.22	21	167270	1384	42452660
Skin toxicity	12.52	10.22	5	167286	6544	42447500
Wrong product administered	12.47	10.22	53	167238	6173	42447871
Pelvic cyst	12.46	10.22	5	167286	35	42454009
Carotid bruit	12.45	10.22	8	167283	164	42453880
Haematuria	12.45	10.22	306	166985	57493	42396551
Substance abuse	12.44	10.22	10	167281	8895	42445149
Back disorder	12.43	10.22	7	167284	7507	42446537
Mesenteric artery embolism	12.38	10.22	6	167285	69	42453975
Blood albumin decreased	12.34	10.22	103	167188	15299	42438745
Dialysis	12.33	10.22	85	167206	11901	42442143
Hyperaesthesia	12.30	10.22	4	167287	5948	42448096
Myocardial ischaemia	12.28	10.22	115	167176	17647	42436397
Faeces discoloured	12.19	10.22	111	167180	16903	42437141
Night sweats	12.16	10.22	39	167252	19930	42434114
Nasal polyps	12.15	10.22	38	167253	3813	42450231
Chronic sinusitis	12.14	10.22	35	167256	3357	42450687
N-telopeptide urine increased	12.11	10.22	5	167286	38	42454006
Drug dose omission by device	12.09	10.22	4	167287	5882	42448162
Central nervous system lesion	12.08	10.22	8	167283	7862	42446182
Renal cyst	12.04	10.22	74	167217	9965	42444079
Cystitis	12.03	10.22	17	167274	11681	42442363
Discoloured vomit	12.02	10.22	15	167276	757	42453287
Gastric ulcer	12.01	10.22	117	167174	18145	42435899
Blood gastrin increased	12.00	10.22	5	167286	39	42454005
Sterile pyuria	12.00	10.22	5	167286	39	42454005
Pyelonephritis	11.92	10.22	62	167229	7852	42446192
Electrocardiogram QRS complex prolonged	11.89	10.22	4	167287	5819	42448225
Enterococcal infection	11.88	10.22	18	167273	12021	42442023
Small for dates baby	11.87	10.22	3	167288	5260	42448784
Cardiac failure congestive	11.81	10.22	251	167040	85351	42368693
Generalised onset non-motor seizure	11.80	10.22	4	167287	16	42454028
Dressler's syndrome	11.80	10.22	4	167287	16	42454028
Blood pressure systolic increased	11.80	10.22	63	167228	27905	42426139
Spinal cord haemorrhage	11.76	10.22	10	167281	319	42453725
Cytomegalovirus infection reactivation	11.74	10.22	16	167275	11162	42442882
Blood immunoglobulin E increased	11.65	10.22	36	167255	3589	42450455
Hyperuricaemia	11.64	10.22	70	167221	9354	42444690
Rhinorrhoea	11.61	10.22	75	167216	31719	42422325
Bacteroides infection	11.59	10.22	29	167262	2558	42451486
Hip fracture	11.59	10.22	22	167269	13450	42440594
Hepatotoxicity	11.58	10.22	55	167236	25112	42428932
Jaundice cholestatic	11.53	10.22	46	167245	5207	42448837
COVID-19	11.46	10.22	357	166934	115591	42338453
Macroglossia	11.45	10.22	12	167279	500	42453544
Gastrointestinal tract irritation	11.45	10.22	10	167281	331	42453713
Pure white cell aplasia	11.41	10.22	6	167285	83	42453961
Campylobacter test positive	11.41	10.22	6	167285	83	42453961
Angina pectoris	11.39	10.22	187	167104	32709	42421335
Cough	11.38	10.22	577	166714	177526	42276518
Adrenal insufficiency	11.37	10.22	119	167172	18805	42435239
Non-small cell lung cancer	11.28	10.22	44	167247	4930	42449114
Cerebellar infarction	11.26	10.22	26	167265	2179	42451865
Blood calcium increased	11.23	10.22	64	167227	8390	42445654
Illness	11.17	10.22	55	167236	24875	42429169
Endoscopy upper gastrointestinal tract	11.11	10.22	5	167286	48	42453996
Reflux gastritis	11.10	10.22	10	167281	345	42453699
Oculocephalogyric reflex absent	11.09	10.22	4	167287	20	42454024
Meniere's disease	11.02	10.22	5	167286	49	42453995
Mesothelioma	10.99	10.22	11	167280	434	42453610
Cerebral hyperperfusion syndrome	10.98	10.22	6	167285	90	42453954
Gastric varices haemorrhage	10.97	10.22	9	167282	273	42453771
Dyslalia	10.97	10.22	13	167278	622	42453422
Lip blister	10.93	10.22	15	167276	832	42453212
Kidney infection	10.87	10.22	54	167237	6716	42447328
Tachypnoea	10.77	10.22	46	167245	21616	42432428
Exposed bone in jaw	10.73	10.22	21	167270	1568	42452476
Renal pain	10.72	10.22	35	167256	3592	42450452
White blood cell count increased	10.72	10.22	242	167049	44845	42409199
Device dislocation	10.68	10.22	9	167282	7822	42446222
Self-injurious ideation	10.63	10.22	23	167268	1845	42452199
Osteonecrosis of jaw	10.62	10.22	118	167173	18931	42435113
Carboxyhaemoglobin increased	10.59	10.22	5	167286	54	42453990
Atypical haemolytic uraemic syndrome	10.58	10.22	12	167279	547	42453497
Inhibitory drug interaction	10.58	10.22	23	167268	1851	42452193
Tendon discomfort	10.52	10.22	10	167281	370	42453674
Immobilisation syndrome	10.37	10.22	11	167280	465	42453579
Embolic cerebral infarction	10.37	10.22	15	167276	874	42453170
Hyperkalaemia	10.36	10.22	400	166891	80058	42373986
Aortic dissection	10.33	10.22	31	167260	3041	42451003
Paranoia	10.32	10.22	25	167266	14001	42440043
Acne	10.29	10.22	24	167267	13620	42440424
Cataract	10.28	10.22	74	167217	30530	42423514
Hypocoagulable state	10.25	10.22	16	167275	997	42453047
Bacterial infection	10.22	10.22	160	167131	27719	42426325

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	1194.62	9.55	2572	425133	1517968	108643626
Colitis microscopic	792.03	9.55	546	427159	12848	110148746
Completed suicide	646.83	9.55	86	427619	242295	109919299
Hyponatraemia	523.79	9.55	1941	425764	215712	109945882
Death	463.28	9.55	1287	426418	697582	109464012
Chronic kidney disease	436.64	9.55	933	426772	75358	110086236
Toxicity to various agents	427.57	9.55	752	426953	479803	109681791
Off label use	377.92	9.55	3849	423856	1496336	108665258
Product dose omission issue	332.41	9.55	455	427250	321327	109840267
Interstitial lung disease	282.66	9.55	1178	426527	138156	110023438
Therapeutic product effect incomplete	264.36	9.55	285	427420	223520	109938074
Lip swelling	255.35	9.55	589	427116	50078	110111516
Drug abuse	255.04	9.55	188	427517	177223	109984371
Swollen tongue	247.21	9.55	648	427057	59714	110101880
Subacute cutaneous lupus erythematosus	232.24	9.55	176	427529	4818	110156776
Hypomagnesaemia	227.03	9.55	628	427077	59742	110101852
Injection site pain	223.26	9.55	215	427490	177707	109983887
Cardiospasm	217.72	9.55	169	427536	4798	110156796
Acute kidney injury	207.61	9.55	3531	424174	631899	109529695
End stage renal disease	207.04	9.55	329	427376	21144	110140450
Palmoplantar keratoderma	197.30	9.55	165	427540	5222	110156372
Angioedema	196.00	9.55	828	426877	97672	110063922
Pruritus genital	191.16	9.55	176	427529	6346	110155248
Fatigue	186.82	9.55	3447	424258	1212511	108949083
Lower respiratory tract infection	186.59	9.55	1591	426114	241515	109920079
Sleep terror	179.57	9.55	171	427534	6439	110155155
Neutropenic sepsis	172.40	9.55	373	427332	30373	110131221
Cerebral infarction	165.84	9.55	509	427196	51329	110110265
Tension headache	163.64	9.55	194	427511	9424	110152170
Atrial tachycardia	159.26	9.55	187	427518	8991	110152603
Appendicolith	153.69	9.55	230	427475	14025	110147569
Pain	151.17	9.55	2692	425013	952263	109209331
Subarachnoid haemorrhage	143.87	9.55	340	427365	29362	110132232
Immunisation	141.04	9.55	109	427596	3074	110158520
Agranulocytosis	137.81	9.55	538	427167	61222	110100372
Cholestasis	135.92	9.55	552	427153	63966	110097628
Liver disorder	135.62	9.55	979	426726	141264	110020330
Confusional state	134.31	9.55	2552	425153	466128	109695466
Swelling face	132.50	9.55	706	426999	91615	110069979
Carotid artery occlusion	132.43	9.55	174	427531	9391	110152203
Drug resistance	130.57	9.55	29	427676	56345	110105249
Chest pain	129.84	9.55	2111	425594	374264	109787330
Hepatic function abnormal	128.93	9.55	684	427021	88611	110072983
Suicide attempt	128.45	9.55	126	427579	103268	110058326
Treatment failure	125.31	9.55	598	427107	276636	109884958
Intentional overdose	124.39	9.55	200	427505	132301	110029293
Appendicitis	120.05	9.55	309	427396	28155	110133439
Deep vein thrombosis postoperative	118.39	9.55	499	427206	58792	110102802
Amnesia	118.09	9.55	755	426950	104653	110056941
Lower limb fracture	115.59	9.55	587	427118	74761	110086833
Renal injury	115.36	9.55	236	427469	18477	110143117
Influenza	114.97	9.55	307	427398	168794	109992800
Rectal haemorrhage	114.36	9.55	825	426880	119008	110042586
Myelosuppression	111.49	9.55	120	427585	94220	110067374
Facial pain	111.04	9.55	207	427498	15132	110146462
Abdominal pain upper	109.77	9.55	1929	425776	347182	109814412
Accidental exposure to product	109.41	9.55	29	427676	49979	110111615
Tubulointerstitial nephritis	108.49	9.55	457	427248	53827	110107767
Anosmia	103.98	9.55	179	427526	12293	110149301
Melaena	102.23	9.55	531	427174	68226	110093368
Autoimmune disorder	101.04	9.55	511	427194	64972	110096622
Haematemesis	100.33	9.55	474	427231	58634	110102960
Injection site reaction	99.05	9.55	119	427586	88951	110072643
Blood pressure increased	98.59	9.55	590	427115	257783	109903811
Electric shock	97.56	9.55	70	427635	1758	110159836
Nephrogenic anaemia	96.10	9.55	103	427602	4474	110157120
Transient ischaemic attack	93.66	9.55	492	427213	63490	110098104
Hypergastrinaemia	92.79	9.55	39	427666	317	110161277
Liver function test abnormal	92.68	9.55	518	427187	68432	110093162
Therapeutic product effect decreased	90.03	9.55	564	427141	243752	109917842
Device expulsion	89.86	9.55	8	427697	30883	110130711
Inappropriate schedule of product administration	89.81	9.55	443	427262	203194	109958400
Overdose	87.55	9.55	537	427168	233257	109928337
Contraindicated product administered	87.47	9.55	581	427124	247686	109913908
Adjustment disorder with depressed mood	86.58	9.55	368	427337	43515	110118079
Lip dry	84.77	9.55	670	427035	99413	110062181
Disease progression	83.53	9.55	576	427129	243458	109918136
Onychomycosis	83.06	9.55	23	427682	38508	110123086
Drug dispensed to wrong patient	81.34	9.55	45	427660	704	110160890
Hypertensive nephropathy	80.12	9.55	50	427655	988	110160606
Hallucination	79.95	9.55	668	427037	100764	110060830
Muscle twitching	79.58	9.55	276	427429	29659	110131935
Hepatic cytolysis	78.98	9.55	421	427284	54632	110106962
Abdominal pain	78.72	9.55	2567	425138	510422	109651172
Ventricular fibrillation	78.09	9.55	342	427363	40971	110120623
Hypocalcaemia	77.45	9.55	475	427230	64891	110096703
Therapy partial responder	76.46	9.55	24	427681	37037	110124557
Wrong technique in product usage process	76.32	9.55	138	427567	87210	110074384
Therapy interrupted	75.26	9.55	50	427655	49772	110111822
Coeliac disease	74.28	9.55	37	427668	43150	110118444
Total lung capacity decreased	74.16	9.55	113	427592	7001	110154593
Hospitalisation	73.07	9.55	293	427412	142200	110019394
Pain of skin	72.97	9.55	206	427499	19823	110141771
Hepatocellular injury	72.46	9.55	387	427318	50255	110111339
Tinnitus	72.40	9.55	441	427264	60099	110101495
Blood cholesterol increased	70.71	9.55	1055	426650	183730	109977864
Dry mouth	70.55	9.55	1126	426579	198822	109962772
Jaundice	70.52	9.55	431	427274	58805	110102789
Injection site swelling	70.37	9.55	81	427624	61709	110099885
Blood uric acid increased	70.35	9.55	213	427492	21316	110140278
Injection site pruritus	70.22	9.55	57	427648	51201	110110393
Product use in unapproved indication	68.68	9.55	1267	426438	446110	109715484
Drug intolerance	68.24	9.55	1133	426572	405379	109756215
X-ray abnormal	67.87	9.55	310	427395	37807	110123787
Loss of personal independence in daily activities	66.93	9.55	325	427380	149695	110011899
Liver injury	66.08	9.55	880	426825	149533	110012061
Cholecystitis chronic	66.03	9.55	126	427579	9374	110152220
Lupus vulgaris	65.96	9.55	283	427422	33600	110127994
Eosinophilia	64.27	9.55	414	427291	57522	110104072
Peripheral venous disease	64.19	9.55	550	427155	83567	110078027
Pulmonary fibrosis	62.70	9.55	637	427068	101405	110060189
Therapy cessation	62.55	9.55	49	427656	44808	110116786
Exposure during pregnancy	62.43	9.55	385	427320	167039	109994555
Rhinorrhoea	62.03	9.55	197	427508	102469	110059125
Hepatotoxicity	61.10	9.55	94	427611	63306	110098288
Antimicrobial susceptibility test resistant	61.08	9.55	31	427674	403	110161191
Renal failure	60.14	9.55	1220	426485	225354	109936240
Sedation	60.07	9.55	111	427594	69572	110092022
Injection site erythema	59.54	9.55	177	427528	93999	110067595
Minimum inhibitory concentration	59.03	9.55	23	427682	150	110161444
Weight increased	57.87	9.55	1210	426495	418434	109743160
Blood lactic acid decreased	57.55	9.55	33	427672	555	110161039
Medication error	57.38	9.55	642	427063	104724	110056870
Wrong patient received product	57.23	9.55	97	427608	6577	110155017
Lung opacity	57.10	9.55	134	427571	11518	110150076
Cardiac output increased	56.37	9.55	33	427672	578	110161016
Eosinophil count decreased	56.36	9.55	91	427614	5927	110155667
Device dislocation	56.30	9.55	26	427679	31678	110129916
Sopor	56.24	9.55	285	427420	36261	110125333
Oedema	55.85	9.55	1131	426574	208845	109952749
Intervertebral discitis	55.25	9.55	98	427607	6892	110154702
Blood phosphorus increased	54.65	9.55	163	427542	16177	110145417
COVID-19	54.64	9.55	645	427060	244415	109917179
Porphyria acute	54.20	9.55	178	427527	18602	110142992
Product use issue	54.19	9.55	863	426842	310832	109850762
Hypokalaemia	54.05	9.55	999	426706	181449	109980145
Red blood cell sedimentation rate abnormal	54.02	9.55	14	427691	24495	110137099
Aplastic anaemia	53.61	9.55	211	427494	24097	110137497
Myasthenia gravis	53.47	9.55	194	427511	21317	110140277
Incorrect dose administered	53.20	9.55	213	427492	103428	110058166
Ventricular tachycardia	52.82	9.55	353	427352	49656	110111938
Poisoning deliberate	52.65	9.55	18	427687	26313	110135281
Mixed liver injury	51.84	9.55	132	427573	11947	110149647
Drug use disorder	51.72	9.55	5	427700	18069	110143525
Palpitations	51.50	9.55	884	426821	158328	110003266
Therapeutic response shortened	51.40	9.55	25	427680	29558	110132036
Haemorrhage subcutaneous	50.84	9.55	83	427622	5456	110156138
Malaise	50.81	9.55	3127	424578	668692	109492902
Venous pressure jugular increased	50.74	9.55	42	427663	1310	110160284
Post-traumatic stress disorder	50.25	9.55	91	427614	6505	110155089
Drug reaction with eosinophilia and systemic symptoms	50.20	9.55	512	427193	81583	110080011
Poisoning	49.96	9.55	25	427680	29080	110132514
Sinus congestion	49.58	9.55	28	427677	30431	110131163
Toxic epidermal necrolysis	49.27	9.55	382	427323	56345	110105249
Faeces discoloured	48.96	9.55	260	427445	33688	110127906
Product dose omission in error	48.91	9.55	15	427690	23497	110138097
Food allergy	48.82	9.55	9	427696	19939	110141655
Neoplasm progression	48.80	9.55	111	427594	64484	110097110
Nasal congestion	48.57	9.55	205	427500	98077	110063517
Haematotoxicity	48.51	9.55	11	427694	21071	110140523
Toxic skin eruption	48.41	9.55	223	427482	27292	110134302
Catarrh	48.19	9.55	95	427610	7240	110154354
Respiratory tract congestion	47.93	9.55	30	427675	30827	110130767
Road traffic accident	47.44	9.55	629	427076	106769	110054825
Adverse reaction	47.04	9.55	28	427677	29566	110132028
Gastric polyps	47.00	9.55	80	427625	5443	110156151
Diplopia	46.86	9.55	300	427405	41594	110120000
Protein-losing gastroenteropathy	46.77	9.55	34	427671	872	110160722
Urticaria	46.39	9.55	1586	426119	317271	109844323
Vitamin B1 decreased	45.68	9.55	34	427671	905	110160689
Cystitis	45.54	9.55	119	427586	65917	110095677
Dislocation of vertebra	45.21	9.55	307	427398	43414	110118180
Rash papular	44.98	9.55	219	427486	27420	110134174
Illness	44.67	9.55	165	427540	82006	110079588
Fall	44.58	9.55	1894	425811	601588	109560006
Marasmus	44.52	9.55	43	427662	1648	110159946
Foetal death	44.47	9.55	5	427700	16040	110145554
Post cholecystectomy syndrome	44.04	9.55	32	427673	820	110160774
Vasculitis	43.96	9.55	263	427442	35610	110125984
Analgesic therapy	43.88	9.55	91	427614	7193	110154401
Muscle injury	43.81	9.55	777	426928	140030	110021564
Sleep disorder therapy	43.45	9.55	92	427613	7379	110154215
Swollen joint count increased	43.41	9.55	505	427200	83156	110078438
Delirium	43.41	9.55	749	426956	134276	110027318
Cough	43.21	9.55	1408	426297	460233	109701361
Hypophosphataemia	43.08	9.55	247	427458	32935	110128659
Blood pressure systolic increased	42.95	9.55	170	427535	82821	110078773
C-reactive protein	42.86	9.55	231	427474	30100	110131494
Onychomadesis	42.77	9.55	69	427636	45594	110116000
Bronchopulmonary aspergillosis allergic	42.49	9.55	98	427607	8328	110153266
Central nervous system mass	42.38	9.55	31	427674	803	110160791
No adverse event	42.32	9.55	145	427560	73694	110087900
Device malfunction	42.32	9.55	23	427682	25535	110136059
Pancreatitis acute	42.31	9.55	387	427318	59887	110101707
Musculoskeletal pain	42.29	9.55	966	426739	182057	109979537
Upper respiratory tract inflammation	42.17	9.55	67	427638	4304	110157290
Wall motion score index abnormal	42.14	9.55	31	427674	810	110160784
Asthma	41.88	9.55	1266	426439	249025	109912569
Renal impairment	41.81	9.55	989	426716	187456	109974138
Joint range of motion decreased	41.80	9.55	683	427022	121149	110040445
Grip strength	41.44	9.55	102	427603	9039	110152555
Inappropriate antidiuretic hormone secretion	41.37	9.55	248	427457	33603	110127991
Decreased appetite	41.34	9.55	2243	425462	473603	109687991
Macular degeneration	41.29	9.55	16	427689	21643	110139951
Infusion related reaction	41.24	9.55	1140	426565	380022	109781572
Reflux gastritis	41.21	9.55	39	427666	1457	110160137
Drug dependence	41.09	9.55	82	427623	49938	110111656
Brain stem glioma	40.86	9.55	19	427686	201	110161393
Dermatitis atopic	40.83	9.55	24	427681	25517	110136077
Femoral neck fracture	40.75	9.55	124	427581	12443	110149151
Arthralgia	40.55	9.55	2536	425169	777096	109384498
Injection site bruising	40.45	9.55	86	427619	51177	110110417
Back injury	40.41	9.55	76	427629	47323	110114271
Blood alkaline phosphatase increased	40.36	9.55	436	427269	70499	110091095
Disease recurrence	40.06	9.55	112	427593	60672	110100922
Circulatory collapse	39.86	9.55	294	427411	42699	110118895
Diabetic nephropathy	39.83	9.55	58	427647	3450	110158144
Product label confusion	39.65	9.55	19	427686	22658	110138936
Drug ineffective for unapproved indication	39.63	9.55	234	427471	102604	110058990
Diarrhoea	39.53	9.55	5007	422698	1134498	109027096
Device difficult to use	39.11	9.55	12	427693	18793	110142801
Sciatica	39.10	9.55	537	427168	91862	110069732
Multiple sclerosis relapse	39.04	9.55	85	427620	50155	110111439
Bursitis	39.04	9.55	713	426992	129205	110032389
Labile blood pressure	39.03	9.55	48	427657	2423	110159171
Airway remodelling	39.02	9.55	31	427674	911	110160683
Blood pressure fluctuation	38.90	9.55	153	427552	74671	110086923
Full blood count decreased	38.85	9.55	40	427665	32059	110129535
Gastritis	38.83	9.55	347	427358	53352	110108242
Hypoparathyroidism secondary	38.81	9.55	20	427685	269	110161325
Rheumatoid nodule	38.68	9.55	15	427690	20281	110141313
Electrocardiogram QT prolonged	38.56	9.55	614	427091	108346	110053248
Sinus disorder	38.25	9.55	42	427663	32686	110128908
Infective pulmonary exacerbation of cystic fibrosis	38.23	9.55	135	427570	14636	110146958
Temperature regulation disorder	38.19	9.55	3	427702	12823	110148771
Purpura	38.10	9.55	191	427514	24197	110137397
Burns second degree	37.97	9.55	89	427616	7644	110153950
Vomiting	37.64	9.55	4047	423658	906628	109254966
Dehydration	37.61	9.55	1378	426327	278133	109883461
Lung disorder	37.26	9.55	936	426769	179111	109982483
Pathogen resistance	37.26	9.55	11	427694	17661	110143933
Device dependence	37.24	9.55	13	427692	59	110161535
Pemphigoid	37.13	9.55	163	427542	19544	110142050
Disseminated intravascular coagulation	36.95	9.55	280	427425	41006	110120588
Activated partial thromboplastin time prolonged	36.95	9.55	178	427527	22190	110139404
Enthesopathy	36.93	9.55	3	427702	12475	110149119
Urine magnesium decreased	36.47	9.55	8	427697	0	110161594
Demyelination	36.35	9.55	99	427606	9330	110152264
Parosmia	36.33	9.55	123	427582	13057	110148537
Immunodeficiency	36.08	9.55	59	427646	38779	110122815
Chills	36.07	9.55	519	427186	190061	109971533
Hypoacusis	36.04	9.55	50	427655	35141	110126453
Hyperphosphataemia	35.97	9.55	142	427563	16239	110145355
Procedural pain	35.96	9.55	51	427654	35514	110126080
Finger deformity	35.96	9.55	45	427660	33047	110128547
Hyperkalaemia	35.95	9.55	731	426974	135065	110026529
Bone pain	35.92	9.55	130	427575	65003	110096591
Cardiac septal defect	35.83	9.55	30	427675	951	110160643
Mental status changes	35.65	9.55	162	427543	75960	110085634
Drug effective for unapproved indication	35.52	9.55	6	427699	14161	110147433
White blood cell count increased	35.51	9.55	549	427156	96293	110065301
Pleuritic pain	35.51	9.55	140	427565	16000	110145594
Coma	35.18	9.55	289	427416	117580	110044014
Pneumonia bacterial	35.09	9.55	197	427508	26064	110135530
Gastrointestinal polyp haemorrhage	35.04	9.55	27	427678	758	110160836
Biliary dyskinesia	35.01	9.55	45	427660	2376	110159218
Erythema multiforme	34.94	9.55	168	427537	20929	110140665
Proctitis	34.85	9.55	11	427694	16916	110144678
Intentional dose omission	34.84	9.55	17	427688	20063	110141531
Nephropathy	34.79	9.55	123	427582	13344	110148250
Skin haemorrhage	34.77	9.55	27	427678	24800	110136794
Enterochromaffin cell hyperplasia	34.70	9.55	13	427692	75	110161519
Tetanus	34.28	9.55	12	427693	55	110161539
Oesophagitis	34.22	9.55	209	427496	28506	110133088
Pneumonia aspiration	33.92	9.55	471	427234	80762	110080832
Pain in extremity	33.64	9.55	1540	426165	485578	109676016
Atopy	33.55	9.55	31	427674	1123	110160471
Limb discomfort	33.53	9.55	67	427638	40787	110120807
Joint swelling	33.48	9.55	1386	426319	441459	109720135
Psoriasis	33.33	9.55	363	427342	139630	110021964
Occupational dermatitis	33.17	9.55	15	427690	148	110161446
Chronic kidney disease-mineral and bone disorder	33.07	9.55	24	427681	614	110160980
Bronchiectasis	32.95	9.55	248	427457	36245	110125349
Transplant rejection	32.81	9.55	28	427677	24539	110137055
Nightmare	32.80	9.55	260	427445	38603	110122991
Steroid dependence	32.72	9.55	89	427616	8380	110153214
Device issue	32.52	9.55	52	427653	34483	110127111
Basal cell carcinoma	32.43	9.55	80	427625	45190	110116404
Neutrophil count decreased	32.33	9.55	652	427053	120289	110041305
Cerebral haemorrhage	32.31	9.55	389	427316	64579	110097015
Obesity	32.30	9.55	617	427088	112734	110048860
Sinusitis	32.17	9.55	887	426818	295801	109865793
Coronary artery disease	32.13	9.55	421	427284	71269	110090325
Hip fracture	32.10	9.55	54	427651	35097	110126497
Neuroendocrine tumour	32.07	9.55	35	427670	1552	110160042
Type 2 diabetes mellitus	31.97	9.55	905	426800	176327	109985267
Gingival pain	31.84	9.55	133	427572	15603	110145991
Vitamin B1 increased	31.75	9.55	15	427690	165	110161429
Oedema peripheral	31.73	9.55	1565	426140	327095	109834499
Drug therapy	31.62	9.55	80	427625	7211	110154383
Muscle spasticity	31.14	9.55	57	427648	35858	110125736
Personality disorder	30.97	9.55	6	427699	12831	110148763
Haemoptysis	30.72	9.55	416	427289	70938	110090656
Nasopharyngitis	30.50	9.55	1231	426474	393130	109768464
Heart rate decreased	30.48	9.55	191	427514	82565	110079029
International normalised ratio increased	30.34	9.55	488	427217	86284	110075310
Female genital tract fistula	30.19	9.55	13	427692	16506	110145088
Aspiration	30.15	9.55	212	427493	30321	110131273
Enteritis infectious	30.14	9.55	54	427651	3828	110157766
Wheezing	30.01	9.55	1240	426465	253990	109907604
Migraine	29.99	9.55	873	426832	170779	109990815
Exposure via skin contact	29.97	9.55	7	427698	13140	110148454
Synovitis	29.83	9.55	819	426886	273273	109888321
Cardiac murmur	29.82	9.55	180	427525	24448	110137146
Pneumonia	29.78	9.55	2953	424752	873761	109287833
Irritable bowel syndrome	29.75	9.55	839	426866	163376	109998218
Hypotension	29.68	9.55	1690	426015	522159	109639435
Hepatic ischaemia	29.58	9.55	30	427675	1221	110160373
Tachypnoea	29.51	9.55	68	427637	39327	110122267
Hypopnoea	29.45	9.55	104	427601	11276	110150318
Epstein-Barr virus infection	29.40	9.55	18	427687	18720	110142874
Cholecystitis acute	29.33	9.55	130	427575	15652	110145942
Immune reconstitution inflammatory syndrome	29.29	9.55	13	427692	16213	110145381
Subdural haematoma	29.21	9.55	241	427464	36213	110125381
Post transplant lymphoproliferative disorder	29.00	9.55	12	427693	15601	110145993
Blood immunoglobulin A increased	28.97	9.55	33	427672	1535	110160059
Panniculitis	28.90	9.55	12	427693	15570	110146024
Coma scale abnormal	28.80	9.55	93	427612	9633	110151961
Genital pain	28.51	9.55	31	427674	1369	110160225
Blindness	28.40	9.55	239	427466	36120	110125474
Somatic delusion	28.32	9.55	23	427682	698	110160896
Cardiotoxicity	28.23	9.55	15	427690	16866	110144728
Hepatitis acute	27.94	9.55	145	427560	18621	110142973
Carcinoid tumour of the stomach	27.86	9.55	14	427691	178	110161416
Hyperchlorhydria	27.80	9.55	38	427667	2131	110159463
Wound infection	27.79	9.55	526	427179	95939	110065655
Incorrect route of product administration	27.79	9.55	374	427331	63687	110097907
Cholangitis	27.72	9.55	131	427574	16204	110145390
Musculoskeletal disorder	27.70	9.55	28	427677	22636	110138958
Neurotoxicity	27.64	9.55	78	427627	42129	110119465
Polyneuropathy	27.58	9.55	51	427654	31961	110129633
Red cell distribution width increased	27.49	9.55	17	427688	17585	110144009
Blood calcium increased	27.28	9.55	140	427565	17900	110143694
Surgery	27.25	9.55	76	427629	41207	110120387
Lethargy	27.22	9.55	511	427194	93065	110068529
Lupus-like syndrome	27.17	9.55	259	427446	40533	110121061
Prescribed overdose	27.13	9.55	483	427222	87098	110074496
Radiculopathy	27.11	9.55	21	427684	19315	110142279
Immune thrombocytopenia	26.98	9.55	164	427541	22330	110139264
Therapeutic response delayed	26.96	9.55	30	427675	1360	110160234
Sensory loss	26.81	9.55	26	427679	21431	110140163
Injury	26.59	9.55	885	426820	176380	109985214
Cardio-respiratory arrest	26.53	9.55	303	427402	115533	110046061
Biliary sepsis	26.25	9.55	34	427671	1809	110159785
Unevaluable event	26.00	9.55	129	427576	59098	110102496
Blood sodium decreased	25.87	9.55	244	427461	38075	110123519
Electrocardiogram QRS complex prolonged	25.86	9.55	9	427696	13012	110148582
Breast cancer stage III	25.83	9.55	440	427265	78677	110082917
Acne	25.81	9.55	57	427648	33463	110128131
Drug dose omission by device	25.63	9.55	12	427693	14504	110147090
Night sweats	25.52	9.55	689	427016	133294	110028300
Gastric dysplasia	25.48	9.55	8	427697	24	110161570
Cardiac arrest	25.44	9.55	573	427132	196180	109965414
Ascites	25.36	9.55	502	427203	92306	110069288
Tetany	25.29	9.55	48	427657	3556	110158038
Lymphadenopathy	25.27	9.55	144	427561	63691	110097903
Hyperlactacidaemia	25.24	9.55	80	427625	8206	110153388
Hypervolaemia	25.16	9.55	102	427603	49358	110112236
Cataract	25.05	9.55	192	427513	79293	110082301
Idiopathic pulmonary fibrosis	25.02	9.55	58	427647	4946	110156648
Urine potassium decreased	24.97	9.55	7	427698	12	110161582
Terminal insomnia	24.91	9.55	34	427671	1904	110159690
Drug hypersensitivity	24.80	9.55	1470	426235	452620	109708974
Gastrointestinal motility disorder	24.73	9.55	73	427632	7203	110154391
Walking aid user	24.70	9.55	174	427531	24901	110136693
Gastric cancer	24.64	9.55	96	427609	10912	110150682
Hyperlipidaemia	24.57	9.55	229	427476	35619	110125975
Facet joint syndrome	24.56	9.55	518	427187	96310	110065284
Aspartate aminotransferase	24.32	9.55	24	427681	945	110160649
Skin candida	24.30	9.55	37	427668	2291	110159303
Abnormal loss of weight	24.23	9.55	91	427614	10166	110151428
Administration site inflammation	24.14	9.55	10	427695	78	110161516
Adjustment disorder	24.11	9.55	6	427699	10789	110150805
Swollen joint count	23.95	9.55	81	427624	8593	110153001
Enterocolitis	23.91	9.55	140	427565	18809	110142785
Respiratory arrest	23.90	9.55	130	427575	58169	110103425
Complication of device insertion	23.88	9.55	3	427702	8835	110152759
Restlessness	23.87	9.55	124	427581	56135	110105459
Muscle spasms	23.69	9.55	1309	426396	276848	109884746
Skin necrosis	23.64	9.55	29	427676	21483	110140111
Upper gastrointestinal haemorrhage	23.63	9.55	297	427408	49799	110111795
Hepatitis cholestatic	23.62	9.55	132	427573	17434	110144160
Cytokine release syndrome	23.51	9.55	167	427538	70139	110091455
Multiple allergies	23.47	9.55	9	427696	12254	110149340
Gastrointestinal toxicity	23.39	9.55	7	427698	11141	110150453
Occupational exposure to air contaminants	23.38	9.55	12	427693	160	110161434
C-reactive protein abnormal	23.31	9.55	662	427043	129033	110032561
Human T-cell lymphotropic virus infection	23.22	9.55	6	427699	6	110161588
Uveitis	23.09	9.55	30	427675	21680	110139914
Device leakage	23.05	9.55	17	427688	16031	110145563
Barrett's oesophagus	23.00	9.55	20	427685	668	110160926
Orthostatic hypotension	22.94	9.55	372	427333	65877	110095717
Rectal ulcer	22.93	9.55	38	427667	2529	110159065
Hypoglobulinaemia	22.81	9.55	13	427692	216	110161378
Eye pruritus	22.78	9.55	210	427495	32565	110129029
Fluid retention	22.66	9.55	244	427461	94063	110067531
Post viral fatigue syndrome	22.64	9.55	14	427691	272	110161322
Skin oedema	22.62	9.55	33	427672	1966	110159628
Mouth ulceration	22.54	9.55	285	427420	47853	110113741
Eye irritation	22.52	9.55	61	427644	33391	110128203
Hospice care	22.51	9.55	10	427695	12463	110149131
Gastric varices	22.48	9.55	22	427683	857	110160737
Therapeutic response decreased	22.26	9.55	252	427453	96247	110065347
Maternal exposure during pregnancy	22.04	9.55	785	426920	254098	109907496
Basilar artery occlusion	22.03	9.55	14	427691	286	110161308
Hyperparathyroidism secondary	21.96	9.55	43	427662	3261	110158333
Retinitis	21.90	9.55	206	427499	32121	110129473
Glomerular filtration rate increased	21.86	9.55	32	427673	1913	110159681
Nail ridging	21.78	9.55	18	427687	560	110161034
Pancreatitis	21.70	9.55	494	427211	93039	110068555
Central nervous system lesion	21.67	9.55	17	427688	15536	110146058
Hypophosphataemic osteomalacia	21.66	9.55	16	427689	421	110161173
Eosinophilic myocarditis	21.57	9.55	33	427672	2052	110159542
Mouth swelling	21.49	9.55	70	427635	7284	110154310
Abortion spontaneous	21.26	9.55	65	427640	34217	110127377
Rheumatoid factor positive	21.24	9.55	663	427042	130977	110030617
Poor venous access	21.19	9.55	39	427666	24483	110137111
Neuropathy, ataxia, retinitis pigmentosa syndrome	21.09	9.55	8	427697	48	110161546
Substance abuse	20.95	9.55	11	427694	12452	110149142
Osteoarthritis	20.95	9.55	885	426820	181738	109979856
Rheumatoid factor increased	20.94	9.55	36	427669	2469	110159125
Renal cyst	20.86	9.55	131	427574	18041	110143553
Platelet count decreased	20.72	9.55	1090	426615	229353	109932241
Nephrocalcinosis	20.61	9.55	30	427675	1784	110159810
Rebound acid hypersecretion	20.55	9.55	10	427695	118	110161476
Muscle relaxant therapy	20.53	9.55	11	427694	161	110161433
Cardioactive drug level increased	20.52	9.55	46	427659	3836	110157758
Secretion discharge	20.50	9.55	29	427676	20215	110141379
Gastric ulcer	20.48	9.55	240	427465	39587	110122007
Rash maculo-papular	20.46	9.55	402	427303	73820	110087774
Skin toxicity	20.41	9.55	10	427695	11773	110149821
Device use error	20.40	9.55	5	427700	9084	110152510
Iron deficiency anaemia	20.34	9.55	199	427506	31360	110130234
Erythema dyschromicum perstans	20.25	9.55	9	427696	85	110161509
Hypoglycaemic coma	20.24	9.55	57	427648	5476	110156118
Flushing	20.24	9.55	284	427421	104452	110057142
Condition aggravated	20.20	9.55	2511	425194	732325	109429269
Genital ulceration	20.06	9.55	31	427674	1944	110159650
Granulocyte count increased	19.97	9.55	31	427674	1952	110159642
Blood pressure abnormal	19.97	9.55	35	427670	22389	110139205
Insurance issue	19.96	9.55	8	427697	10604	110150990
Akathisia	19.96	9.55	22	427683	17091	110144503
Unintentional medical device removal	19.85	9.55	5	427700	8918	110152676
Fear of injection	19.81	9.55	5	427700	8906	110152688
Acute coronary syndrome	19.71	9.55	155	427550	22957	110138637
Colitis ulcerative	19.66	9.55	414	427291	76949	110084645
Maternal exposure timing unspecified	19.65	9.55	144	427561	20869	110140725
Rash vesicular	19.63	9.55	110	427595	14542	110147052
Achlorhydria	19.62	9.55	6	427699	16	110161578
Myocardial ischaemia	19.58	9.55	173	427532	26511	110135083
Sneezing	19.58	9.55	61	427644	31923	110129671
Nausea	19.51	9.55	4356	423349	1231334	108930260
Pulmonary thrombosis	19.51	9.55	15	427690	13848	110147746
Gastrointestinal tract irritation	19.50	9.55	20	427685	825	110160769
Leukocytosis	19.43	9.55	125	427580	53703	110107891
Carbuncle	19.25	9.55	26	427679	1441	110160153
Prostate tenderness	19.25	9.55	8	427697	63	110161531
Product preparation error	19.20	9.55	9	427696	10870	110150724
Acute respiratory failure	19.20	9.55	192	427513	75068	110086526
Vitamin B12 increased	19.14	9.55	31	427674	2024	110159570
Cardiac failure	19.05	9.55	898	426807	186728	109974866
Blood iron decreased	18.98	9.55	28	427677	19186	110142408
Herpes zoster	18.84	9.55	300	427405	108079	110053515
Pericarditis	18.82	9.55	1032	426673	218082	109943512
Anticoagulation drug level abnormal	18.81	9.55	13	427692	307	110161287
Face oedema	18.70	9.55	205	427500	33264	110128330
Thrombotic cerebral infarction	18.70	9.55	19	427686	775	110160819
Cystitis escherichia	18.70	9.55	19	427686	775	110160819
Hyperglycaemia	18.69	9.55	446	427259	84644	110076950
Renal atrophy	18.68	9.55	33	427672	2313	110159281
BK virus infection	18.68	9.55	14	427691	13092	110148502
Iron deficiency	18.66	9.55	129	427576	18347	110143247
Hyponatraemic syndrome	18.64	9.55	19	427686	778	110160816
Blood parathyroid hormone decreased	18.63	9.55	14	427691	13075	110148519
Carotid artery thrombosis	18.57	9.55	7	427698	9631	110151963
Respiratory tract infection	18.56	9.55	182	427523	71435	110090159
Dilatation atrial	18.55	9.55	44	427661	3808	110157786
Mucormycosis	18.44	9.55	9	427696	10619	110150975
Increased viscosity of upper respiratory secretion	18.42	9.55	17	427688	615	110160979
Haemodynamic instability	18.39	9.55	38	427667	22850	110138744
Motor dysfunction	18.38	9.55	42	427663	24364	110137230
Premature delivery	18.34	9.55	59	427646	30573	110131021
Anal prolapse	18.33	9.55	8	427697	72	110161522
Adrenal insufficiency	18.19	9.55	247	427458	42143	110119451
Disturbance in attention	18.19	9.55	339	427366	61656	110099938
Injection site urticaria	18.09	9.55	24	427681	17191	110144403
Product monitoring error	18.03	9.55	6	427699	8921	110152673
Psychotic disorder	18.02	9.55	119	427586	50818	110110776
Chronic graft versus host disease	18.00	9.55	7	427698	9450	110152144
Therapeutic response unexpected	17.98	9.55	41	427664	23802	110137792
Urine output decreased	17.90	9.55	135	427570	19741	110141853
Injection site rash	17.89	9.55	40	427665	23379	110138215
Heart rate irregular	17.86	9.55	70	427635	34204	110127390
Alcoholic liver disease	17.85	9.55	16	427689	557	110161037
Urinary tract infection	17.84	9.55	1056	426649	325226	109836368
Septic shock	17.83	9.55	468	427237	157060	110004534
Eosinophilic pneumonia	17.81	9.55	65	427640	7162	110154432
Rash morbilliform	17.52	9.55	69	427636	7882	110153712
Injection site haemorrhage	17.51	9.55	67	427638	32961	110128633
Neoplasm malignant	17.42	9.55	79	427626	37064	110124530
Joint effusion	17.40	9.55	34	427671	20871	110140723
Extravasation blood	17.33	9.55	15	427690	498	110161096
Hiatus hernia	17.27	9.55	173	427532	27433	110134161
Drug level below therapeutic	17.25	9.55	12	427693	11661	110149933
Sarcoidosis	17.21	9.55	14	427691	12565	110149029
Ocular myasthenia	17.21	9.55	18	427687	760	110160834
Ulcer	17.20	9.55	248	427457	42868	110118726
Aspergillus infection	17.03	9.55	47	427658	25569	110136025
Vasculitic rash	17.02	9.55	31	427674	2226	110159368
Nasal oedema	16.92	9.55	3	427702	6836	110154758
Breast cancer female	16.91	9.55	14	427691	12454	110149140
Altered state of consciousness	16.87	9.55	315	427390	57311	110104283
Radiation pneumonitis	16.86	9.55	47	427658	4489	110157105
Breast cancer stage II	16.86	9.55	171	427534	27204	110134390
Vaginal discharge	16.83	9.55	27	427678	17881	110143713
Drug eruption	16.65	9.55	296	427409	53363	110108231
Metabolic disorder	16.63	9.55	10	427695	10500	110151094
Upper limb fracture	16.51	9.55	35	427670	20853	110140741
Joint injury	16.49	9.55	89	427616	39905	110121689
Pituitary tumour benign	16.49	9.55	35	427670	2812	110158782
Blood test abnormal	16.47	9.55	176	427529	28378	110133216
Blood gastrin increased	16.44	9.55	7	427698	59	110161535
SARS-CoV-2 test positive	16.42	9.55	25	427680	16910	110144684
Metastases to bone	16.40	9.55	64	427641	31308	110130286
Oesophageal achalasia	16.40	9.55	20	427685	1001	110160593
Hepatic enzyme increased	16.25	9.55	1046	426659	319846	109841748
Enterocolitis haemorrhagic	16.24	9.55	33	427672	2571	110159023
Ventricular hypertrophy	16.23	9.55	62	427643	6983	110154611
Oesophageal mucosal tear	16.17	9.55	5	427700	14	110161580
Aortic stenosis	16.17	9.55	96	427609	12963	110148631
Pelvic cyst	16.14	9.55	7	427698	62	110161532
Transplant dysfunction	16.13	9.55	6	427699	8322	110153272
Skin burning sensation	16.08	9.55	38	427667	21787	110139807
Pancreatic carcinoma recurrent	16.05	9.55	10	427695	197	110161397
Localised infection	16.03	9.55	99	427606	42949	110118645
Picornavirus infection	15.98	9.55	9	427696	146	110161448
Blood pressure diastolic abnormal	15.97	9.55	49	427656	25766	110135828
Influenza like illness	15.95	9.55	243	427462	88169	110073425
Rhinitis	15.95	9.55	145	427560	22400	110139194
Haemorrhagic cerebral infarction	15.94	9.55	24	427681	1471	110160123
Acute graft versus host disease in skin	15.92	9.55	11	427694	10729	110150865
Penile curvature	15.92	9.55	5	427700	15	110161579
Vitamin B12 deficiency	15.88	9.55	79	427626	9976	110151618
Underdose	15.85	9.55	163	427542	63391	110098203
Stoma site haemorrhage	15.68	9.55	31	427674	2367	110159227
Middle insomnia	15.67	9.55	35	427670	20467	110141127
Duodenal ulcer perforation	15.67	9.55	839	426866	176861	109984733
Weight decreased	15.64	9.55	1578	426127	466479	109695115
Acute myeloid leukaemia	15.61	9.55	85	427620	38025	110123569
Plasma cell myeloma recurrent	15.56	9.55	4	427701	7038	110154556
Hiccups	15.54	9.55	94	427611	12775	110148819
Cerebral mass effect	15.50	9.55	31	427674	2388	110159206
Embolic stroke	15.48	9.55	71	427634	8672	110152922
Immobilisation syndrome	15.45	9.55	18	427687	858	110160736
Malignant melanoma	15.37	9.55	26	427679	16865	110144729
Photodermatosis	15.34	9.55	20	427685	1071	110160523
Oxygen saturation decreased	15.33	9.55	476	427229	156506	110005088
Neurological symptom	15.17	9.55	23	427682	15585	110146009
Muscle tension dysphonia	15.17	9.55	11	427694	281	110161313
Syringe issue	15.16	9.55	9	427696	9516	110152078
Multiple drug therapy	15.14	9.55	6	427699	8008	110153586
Pulmonary oedema	15.12	9.55	286	427419	100373	110061221
Bradycardia	15.09	9.55	741	426964	154776	110006818
Alcohol poisoning	15.06	9.55	72	427633	8948	110152646
Neuroleptic malignant syndrome	15.06	9.55	74	427631	33985	110127609
Respiratory depression	15.05	9.55	68	427637	31933	110129661
Bile duct stone	15.03	9.55	56	427649	6233	110155361
Anaemia vitamin B12 deficiency	14.98	9.55	21	427684	1206	110160388
Graft versus host disease in gastrointestinal tract	14.95	9.55	8	427697	8960	110152634
Macroglossia	14.94	9.55	23	427682	1438	110160156
Dysphagia	14.93	9.55	732	426973	152868	110008726
Bronchitis	14.89	9.55	478	427227	156554	110005040
Cutaneous lupus erythematosus	14.85	9.55	38	427667	3450	110158144
Hypozincaemia	14.82	9.55	7	427698	77	110161517
Urine phosphorus decreased	14.80	9.55	6	427699	44	110161550
Endocarditis enterococcal	14.75	9.55	12	427693	365	110161229
Hepatic cirrhosis	14.71	9.55	354	427351	67272	110094322
Prostatic specific antigen increased	14.68	9.55	16	427689	12495	110149099
Failure to anastomose	14.62	9.55	10	427695	232	110161362
Body temperature increased	14.62	9.55	138	427567	54575	110107019
Osteonecrosis of jaw	14.58	9.55	264	427441	47753	110113841
Enterococcal infection	14.58	9.55	36	427669	20330	110141264
Osteopenia	14.58	9.55	41	427664	22168	110139426
Hepatorenal syndrome	14.57	9.55	45	427660	4552	110157042
Burn oral cavity	14.55	9.55	9	427696	175	110161419
Acute graft versus host disease	14.54	9.55	17	427688	12864	110148730
Oropharyngeal oedema	14.51	9.55	13	427692	452	110161142
Laryngotracheal oedema	14.47	9.55	6	427699	47	110161547
Follicular mucinosis	14.45	9.55	5	427700	22	110161572
Embolic cerebral infarction	14.41	9.55	23	427682	1483	110160111
Hyperuricaemia	14.41	9.55	101	427604	14430	110147164
Melanoderma	14.39	9.55	13	427692	457	110161137
Rhabdomyolysis	14.38	9.55	586	427119	119815	110041779
Cardiogenic shock	14.30	9.55	306	427399	57032	110104562
Sedation complication	14.29	9.55	35	427670	19820	110141774
Cytomegalovirus infection reactivation	14.26	9.55	31	427674	18302	110143292
Body temperature decreased	14.25	9.55	84	427621	36851	110124743
Cerebellar infarction	14.22	9.55	42	427663	4145	110157449
Cholecystitis	14.22	9.55	158	427547	25724	110135870
Visual impairment	14.21	9.55	646	427059	133782	110027812
Subcutaneous drug absorption impaired	14.17	9.55	63	427642	7596	110153998
Mesenteric artery embolism	14.14	9.55	7	427698	86	110161508
Laryngeal pain	14.11	9.55	53	427652	5922	110155672
Blood pressure systolic abnormal	14.10	9.55	49	427656	24801	110136793
Folliculitis	14.08	9.55	788	426917	166865	109994729
Fungal infection	14.07	9.55	127	427578	50679	110110915
Myositis	14.05	9.55	183	427522	30933	110130661
Arterial intramural haematoma	14.05	9.55	10	427695	248	110161346
Syncope	14.03	9.55	936	426769	201600	109959994
Bleeding time prolonged	14.02	9.55	21	427684	1281	110160313
Palatal ulcer	14.01	9.55	10	427695	249	110161345
Intentional self-injury	13.98	9.55	86	427619	37343	110124251
Blood creatine phosphokinase increased	13.97	9.55	376	427329	72701	110088893
Essential thrombocythaemia	13.92	9.55	12	427693	396	110161198
Vitamin D decreased	13.92	9.55	16	427689	12199	110149395
Haematuria	13.91	9.55	420	427285	82585	110079009
Upper-airway cough syndrome	13.90	9.55	25	427680	15832	110145762
Skin wrinkling	13.89	9.55	23	427682	1530	110160064
Anticoagulant therapy	13.88	9.55	49	427656	5312	110156282
Chronic sinusitis	13.87	9.55	50	427655	25034	110136560
Colon cancer	13.87	9.55	110	427595	16333	110145261
Tuberculosis	13.87	9.55	30	427675	17744	110143850
Chromaturia	13.82	9.55	174	427531	29186	110132408
Dermatitis exfoliative	13.78	9.55	83	427622	11264	110150330
Nephropathy toxic	13.77	9.55	57	427648	27421	110134173
Sluggishness	13.76	9.55	6	427699	7561	110154033
Faecal vomiting	13.75	9.55	23	427682	1543	110160051
Dyspnoea exertional	13.75	9.55	302	427403	103758	110057836
Renal hypertension	13.74	9.55	10	427695	257	110161337
Scratch	13.74	9.55	18	427687	12961	110148633
Spleen congestion	13.73	9.55	13	427692	486	110161108
Infusion site streaking	13.68	9.55	14	427691	576	110161018
Peritoneal mesothelioma malignant	13.68	9.55	3	427702	0	110161594
Oesophageal anastomosis	13.68	9.55	3	427702	0	110161594
Glycated albumin increased	13.68	9.55	3	427702	0	110161594
Lip oedema	13.67	9.55	62	427643	7538	110154056
Posterior reversible encephalopathy syndrome	13.61	9.55	76	427629	33785	110127809
Hypovitaminosis	13.57	9.55	22	427683	1438	110160156
Aortic dissection	13.56	9.55	46	427659	4887	110156707
Blister	13.55	9.55	1038	426667	226338	109935256
Heat illness	13.51	9.55	16	427689	776	110160818
Renal function test abnormal	13.48	9.55	9	427696	8937	110152657
Metastases to lung	13.41	9.55	45	427660	23018	110138576
Lacunar infarction	13.41	9.55	54	427651	6232	110155362
Drug specific antibody present	13.38	9.55	8	427697	8426	110153168
Adverse drug reaction	13.36	9.55	517	427188	105042	110056552
Paradoxical drug reaction	13.34	9.55	11	427694	9806	110151788
Ankylosing spondylitis	13.34	9.55	25	427680	15587	110146007
Neutrophil count increased	13.30	9.55	198	427507	34454	110127140
Contraindication to medical treatment	13.30	9.55	21	427684	1342	110160252
Gastrointestinal infection	13.27	9.55	21	427684	13984	110147610
Seasonal allergy	13.25	9.55	36	427669	19686	110141908
Encephalopathy	13.22	9.55	227	427478	80828	110080766
Pregnancy	13.21	9.55	274	427431	50793	110110801
Respiratory syncytial virus test positive	13.19	9.55	22	427683	1472	110160122
Vulvovaginal candidiasis	13.17	9.55	35	427670	3250	110158344
Hypophagia	13.17	9.55	281	427424	52345	110109249
Neurologic neglect syndrome	13.16	9.55	10	427695	9288	110152306
Progressive multifocal leukoencephalopathy	13.10	9.55	151	427554	24805	110136789
Skin cancer	13.08	9.55	31	427674	17753	110143841
Intracranial haematoma	13.08	9.55	18	427687	1016	110160578
Oculomucocutaneous syndrome	13.08	9.55	11	427694	351	110161243
Creatinine renal clearance decreased	13.08	9.55	42	427663	21773	110139821
Product prescribing error	13.07	9.55	131	427574	51200	110110394
Blood albumin decreased	13.07	9.55	164	427541	27488	110134106
Nephrosclerosis	13.07	9.55	26	427679	1995	110159599
Pseudocellulitis	13.03	9.55	12	427693	433	110161161
Mitral valve replacement	12.99	9.55	14	427691	612	110160982
Coordination abnormal	12.96	9.55	152	427553	25076	110136518
Dyslalia	12.91	9.55	21	427684	1376	110160218
Vision blurred	12.89	9.55	390	427315	128632	110032962
Respiratory failure	12.85	9.55	691	427014	214641	109946953
Clostridium test positive	12.80	9.55	79	427626	10814	110150780
Gallbladder injury	12.78	9.55	20	427685	1268	110160326
Polyomavirus-associated nephropathy	12.70	9.55	8	427697	8193	110153401
Adenoidectomy	12.69	9.55	8	427697	161	110161433
Oral mucosal discolouration	12.69	9.55	11	427694	366	110161228
Anaemia	12.67	9.55	2351	425354	544735	109616859
Product administration interrupted	12.64	9.55	15	427690	11277	110150317
Drug interaction	12.61	9.55	2159	425546	498024	109663570
Endoscopic retrograde cholangiopancreatography	12.58	9.55	9	427696	225	110161369
Hypocalciuria	12.53	9.55	5	427700	35	110161559
Joint noise	12.46	9.55	46	427659	5097	110156497
Erectile dysfunction	12.45	9.55	118	427587	18438	110143156
Staphylococcus test positive	12.43	9.55	59	427646	7311	110154283
Brain stem haemorrhage	12.42	9.55	24	427681	1802	110159792
Single functional kidney	12.41	9.55	10	427695	300	110161294
Upper respiratory tract infection	12.39	9.55	400	427305	130928	110030666
Thalamus haemorrhage	12.38	9.55	25	427680	1939	110159655
Cerebral ventricular rupture	12.36	9.55	12	427693	463	110161131
Sleep disorder due to general medical condition, insomnia type	12.35	9.55	513	427192	105130	110056464
Dysphemia	12.32	9.55	39	427666	3998	110157596
Human herpesvirus 6 infection	12.32	9.55	5	427700	6576	110155018
Pharyngeal oedema	12.31	9.55	107	427598	16321	110145273
Ocular discomfort	12.31	9.55	9	427696	8524	110153070
Microangiopathy	12.26	9.55	32	427673	2940	110158654
Fibromyalgia	12.22	9.55	792	426913	170117	109991477
Pharyngotonsillitis	12.21	9.55	10	427695	307	110161287
Feeling jittery	12.21	9.55	24	427681	14698	110146896
Diffuse vasculitis	12.19	9.55	7	427698	118	110161476
Microcytic anaemia	12.15	9.55	52	427653	6166	110155428
C-reactive protein increased	12.14	9.55	704	427001	217215	109944379
Tongue disorder	12.12	9.55	23	427682	14275	110147319
Contusion	12.08	9.55	1054	426651	232307	109929287
Gait disturbance	12.08	9.55	919	426786	277289	109884305
Anal spasm	12.03	9.55	8	427697	177	110161417
Dermatitis bullous	12.02	9.55	112	427593	17417	110144177
Hypocholesterolaemia	12.01	9.55	53	427652	6368	110155226
Neutrophil count	11.98	9.55	11	427694	395	110161199
Discoloured vomit	11.92	9.55	25	427680	1992	110159602
Deformity	11.92	9.55	13	427692	10147	110151447
Cardiac septal hypertrophy	11.91	9.55	11	427694	398	110161196
Adenovirus infection	11.89	9.55	15	427690	10979	110150615
Cognitive disorder	11.89	9.55	432	427273	87079	110074515
Memory impairment	11.88	9.55	900	426805	196044	109965550
Spinal operation	11.84	9.55	15	427690	10957	110150637
Myocardial infarction	11.79	9.55	879	426826	191204	109970390
N-telopeptide urine increased	11.75	9.55	5	427700	42	110161552
Skin exfoliation	11.69	9.55	254	427451	87397	110074197
Needle issue	11.66	9.55	33	427672	17807	110143787
Cushingoid	11.64	9.55	17	427688	11695	110149899
Cytomegalovirus test positive	11.63	9.55	56	427649	6980	110154614
Pyelonephritis acute	11.63	9.55	57	427648	7156	110154438
Ovarian fibroma	11.62	9.55	6	427699	81	110161513
Anti A antibody	11.61	9.55	3	427702	3	110161591
Temperature intolerance	11.59	9.55	93	427612	13857	110147737
Hemiplegia	11.58	9.55	47	427658	22735	110138859
Productive cough	11.55	9.55	345	427360	113960	110047634
Hepatic enzyme	11.53	9.55	45	427660	5118	110156476
Glossitis	11.53	9.55	41	427664	4460	110157134
Foot operation	11.51	9.55	7	427698	7306	110154288
Incorrect dose administered by device	11.48	9.55	6	427699	6808	110154786
Rheumatic fever	11.46	9.55	582	427123	121997	110039597
Blood magnesium decreased	11.41	9.55	123	427582	19873	110141721
Gallbladder disorder	11.38	9.55	128	427577	20901	110140693
Pre-eclampsia	11.38	9.55	10	427695	8640	110152954
Atypical fracture	11.38	9.55	17	427688	1035	110160559
Duodenal neoplasm	11.37	9.55	6	427699	85	110161509
Lymphocyte stimulation test positive	11.33	9.55	17	427688	1039	110160555
Rectal ulcer haemorrhage	11.33	9.55	10	427695	341	110161253
Cardiac failure congestive	11.30	9.55	473	427232	150527	110011067
Blood loss anaemia	11.30	9.55	34	427671	17991	110143603
Withdrawal syndrome	11.26	9.55	73	427632	31307	110130287
Intentional product use issue	11.23	9.55	816	426889	247090	109914504
Concussion	11.22	9.55	17	427688	11521	110150073
Hypoglycaemia	11.21	9.55	553	427152	115551	110046043
Flashback	11.19	9.55	11	427694	431	110161163
Eosinophilic oesophagitis	11.16	9.55	19	427686	1293	110160301
Ulcer haemorrhage	11.16	9.55	135	427570	22436	110139158
Vascular skin disorder	11.15	9.55	4	427701	20	110161574
Congenital bowing of long bones	11.15	9.55	4	427701	20	110161574
Hysterectomy	11.14	9.55	9	427696	8105	110153489
Gastric ulcer haemorrhage	11.11	9.55	72	427633	10022	110151572
Violence-related symptom	11.10	9.55	16	427689	943	110160651
Biopsy muscle abnormal	11.09	9.55	5	427700	49	110161545
Overweight	11.08	9.55	52	427653	6412	110155182
Fasciitis	11.07	9.55	16	427689	945	110160649
Rapid eye movement sleep behaviour disorder	11.05	9.55	13	427692	626	110160968
Caesarean section	11.05	9.55	23	427682	13794	110147800
Venous thrombosis limb	11.05	9.55	45	427660	5220	110156374
Haemophagocytic lymphohistiocytosis	11.03	9.55	74	427631	31485	110130109
Pharyngeal inflammation	11.02	9.55	22	427683	1692	110159902
Antineutrophil cytoplasmic antibody positive	11.00	9.55	3	427702	5073	110156521
Putamen haemorrhage	10.98	9.55	12	427693	533	110161061
Flank pain	10.96	9.55	49	427656	23081	110138513
Lip blister	10.96	9.55	33	427672	3292	110158302
Urinary straining	10.83	9.55	5	427700	52	110161542
Infusion site pain	10.82	9.55	33	427672	17386	110144208
Skin irritation	10.80	9.55	30	427675	16289	110145305
Urine calcium/creatinine ratio increased	10.80	9.55	7	427698	148	110161446
Alanine aminotransferase increased	10.79	9.55	838	426867	182935	109978659
Autonomic neuropathy	10.78	9.55	26	427679	2274	110159320
Accidental death	10.78	9.55	3	427702	5006	110156588
Anaphylactic reaction	10.75	9.55	543	427162	113757	110047837
Peptic ulcer	10.74	9.55	58	427647	7561	110154033
Meniere's disease	10.72	9.55	7	427698	150	110161444
Foetal exposure during pregnancy	10.72	9.55	8	427697	7497	110154097
Strongyloidiasis	10.70	9.55	3	427702	4983	110156611
Nocardiosis	10.66	9.55	8	427697	7478	110154116
Amenorrhoea	10.62	9.55	12	427693	9219	110152375
Vaginal cellulitis	10.62	9.55	6	427699	98	110161496
Acute hepatic failure	10.61	9.55	90	427615	36378	110125216
Periorbital swelling	10.60	9.55	4	427701	5501	110156093
Spirometry abnormal	10.58	9.55	4	427701	5493	110156101
Hepatic atrophy	10.56	9.55	11	427694	462	110161132
Procedural failure	10.56	9.55	7	427698	154	110161440
Balanoposthitis	10.50	9.55	19	427686	1357	110160237
Anxiety	10.48	9.55	1505	426200	343573	109818021
Full blood count abnormal	10.47	9.55	153	427552	55899	110105695
Gestational diabetes	10.39	9.55	8	427697	7381	110154213
Diabetes mellitus	10.37	9.55	477	427228	98904	110062690
Depression	10.37	9.55	1390	426315	315945	109845649
Pure white cell aplasia	10.37	9.55	7	427698	159	110161435
Gastrostomy tube site complication	10.34	9.55	8	427697	226	110161368
Scleritis	10.34	9.55	4	427701	5416	110156178
Acanthosis	10.33	9.55	12	427693	570	110161024
Cytopenia	10.33	9.55	71	427634	30045	110131549
Product storage error	10.32	9.55	46	427659	21682	110139912
Pneumocystis jirovecii pneumonia	10.31	9.55	227	427478	42508	110119086
Product quality issue	10.31	9.55	224	427481	77075	110084519
Aortic aneurysm rupture	10.27	9.55	19	427686	1381	110160213
Hypersensitivity pneumonitis	10.27	9.55	44	427661	5221	110156373
Paranasal sinus discomfort	10.26	9.55	6	427699	6399	110155195
Constipation	10.22	9.55	1555	426150	356231	109805363
Granuloma	10.21	9.55	13	427692	9477	110152117
Dermatitis acneiform	10.21	9.55	84	427621	12611	110148983
Treatment noncompliance	10.17	9.55	210	427495	72780	110088814
Mycobacterium avium complex infection	10.16	9.55	5	427700	5872	110155722
Inflammatory bowel disease	10.16	9.55	55	427650	7179	110154415
Carotid artery stenosis	10.15	9.55	66	427639	9197	110152397
Dressler's syndrome	10.15	9.55	4	427701	27	110161567
Vulval haemorrhage	10.15	9.55	4	427701	27	110161567
Uterine perforation	10.15	9.55	7	427698	6833	110154761
Unintended pregnancy	10.12	9.55	3	427702	4805	110156789
Gastroenteritis staphylococcal	10.12	9.55	9	427696	310	110161284
Pulmonary embolism	10.08	9.55	962	426743	213512	109948082
Acute myocardial infarction	10.06	9.55	408	427297	83369	110078225
Tendon discomfort	10.02	9.55	12	427693	589	110161005
Dialysis	9.99	9.55	118	427587	19501	110142093
Narrow anterior chamber angle	9.92	9.55	7	427698	171	110161423
Injection site extravasation	9.87	9.55	15	427690	10154	110151440
Abulia	9.86	9.55	18	427687	1295	110160299
Rash papulosquamous	9.85	9.55	7	427698	173	110161421
Strangury	9.84	9.55	8	427697	243	110161351
Frequent bowel movements	9.84	9.55	353	427352	71037	110090557
Irritability	9.83	9.55	128	427577	47681	110113913
Alanine aminotransferase abnormal	9.82	9.55	13	427692	9321	110152273
Respiratory muscle weakness	9.80	9.55	10	427695	410	110161184
Incision site complication	9.78	9.55	14	427691	820	110160774
Coagulation test abnormal	9.77	9.55	20	427685	1566	110160028
Neoplasm recurrence	9.75	9.55	4	427701	5228	110156366
Burning feet syndrome	9.73	9.55	8	427697	247	110161347
Nasal mucosal erosion	9.72	9.55	5	427700	67	110161527
Abortion induced	9.70	9.55	10	427695	8009	110153585
Metastases to lymph nodes	9.68	9.55	28	427677	15004	110146590
Nephrolithiasis	9.68	9.55	189	427516	66023	110095571
Pressure of speech	9.67	9.55	18	427687	1314	110160280
Renal tubular acidosis	9.66	9.55	40	427665	4675	110156919
Bacteroides infection	9.65	9.55	29	427676	2890	110158704
Gastrooesophageal reflux disease	9.65	9.55	815	426890	179161	109982433
Sinus node dysfunction	9.64	9.55	64	427641	8983	110152611
Prothrombin time ratio increased	9.63	9.55	9	427696	331	110161263
Multiple organ dysfunction syndrome	9.61	9.55	696	427009	151014	110010580
Diabetic metabolic decompensation	9.60	9.55	35	427670	3854	110157740
Gallbladder hypofunction	9.60	9.55	11	427694	515	110161079
Renal artery stenosis	9.60	9.55	34	427671	3692	110157902
Oropharyngeal swelling	9.57	9.55	19	427686	1455	110160139
Eosinophil count increased	9.57	9.55	124	427581	20934	110140660
Increased appetite	9.57	9.55	28	427677	14949	110146645
Paramnesia	9.57	9.55	4	427701	32	110161562

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A02BC03	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Proton pump inhibitors
ATC	A02BC53	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Proton pump inhibitors
ATC	A02BD02	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori
ATC	A02BD03	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori
ATC	A02BD07	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori
ATC	A02BD09	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori
ATC	A02BD10	ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori
FDA MoA	N0000000147	Proton Pump Inhibitors
FDA PE	N0000009724	Inhibition Gastric Acid Secretion
FDA EPC	N0000175525	Proton Pump Inhibitor
CHEBI has role	CHEBI:33282	antibacterial agent
CHEBI has role	CHEBI:35480	analgesic
CHEBI has role	CHEBI:35526	hypoglycemic agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:35845	gout suppressant
CHEBI has role	CHEBI:49200	EC 3.6.3.10 (<em>H</em><small><sup>+</small></sup>/<em>K</em><small><sup>+</small></sup>-exchanging ATPase) inhibitor
CHEBI has role	CHEBI:49201	anti-ulcer drug
CHEBI has role	CHEBI:233423	antifibrotic agent
MeSH PA	D000897	Anti-Ulcer Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D054328	Proton Pump Inhibitors

Related Drugs by ATC class:

A02BC Proton pump inhibitors 8 drugs

dexlansoprazole dexrabeprazole esomeprazole ilaprazole omeprazole pantoprazole rabeprazole vonoprazan

A02BD Combinations for eradication of Helicobacter pylori 13 drugs

amoxicillin bismuth subcitrate clarithromycin esomeprazole levofloxacin metronidazole omeprazole pantoprazole rabeprazole rifabutin tetracycline tinidazole show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Peptic ulcer	indication	13200003	DOID:750
Erosive esophagitis	indication	40719004
Duodenal ulcer disease	indication	51868009	DOID:1724
Zollinger-Ellison syndrome	indication	53132006	DOID:0050782
Gastroesophageal reflux disease	indication	235595009	DOID:8534
Gastric ulcer	indication	397825006	DOID:10808
NSAID-Induced Gastric Ulcer	indication
Gastric Hypersecretory Conditions	indication
Duodenal Ulcer due to H. Pylori	indication
Maintenance of Healing Duodenal Ulcer	indication
Upper gastrointestinal hemorrhage	off-label use	37372002
Pathological Gastric Hypersecretory Condition	off-label use
Prevention of Stress Ulcer	off-label use
Prevention of Acute Gastrointestinal Ulcer Re-Bleed	off-label use
Alcoholism	contraindication	7200002
Myocardial infarction	contraindication	22298006	DOID:5844
Ventricular tachycardia	contraindication	25569003
Obstruction of bile duct	contraindication	30144000
Torsades de pointes	contraindication	31722008
Hypertensive disorder	contraindication	38341003	DOID:10763
Gastrointestinal ulcer	contraindication	40845000
Body fluid retention	contraindication	43498006
Chronic heart failure	contraindication	48447003
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Blood coagulation disorder	contraindication	64779008	DOID:1247
Osteoporosis	contraindication	64859006	DOID:11476
Gastrointestinal hemorrhage	contraindication	74474003
Kidney disease	contraindication	90708001	DOID:557
Myasthenia gravis	contraindication	91637004	DOID:437
Cholestatic hepatitis	contraindication	95556007
Prolonged QT interval	contraindication	111975006
Fracture of bone	contraindication	125605004
Liver function tests abnormal	contraindication	166603001
Hypomagnesemia	contraindication	190855004
Cerebrovascular accident	contraindication	230690007
Coronary artery bypass graft	contraindication	232717009
Disease of liver	contraindication	235856003	DOID:409
Esophageal dysmotility	contraindication	266434009	DOID:9192
Edema	contraindication	267038008
Infectious mononucleosis	contraindication	271558008	DOID:8568
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thromboembolic disorder	contraindication	371039008
Cardiovascular event risk	contraindication	395112001
Pseudomembranous enterocolitis	contraindication	397683000
Porphyria	contraindication	418470004
Smokes tobacco daily	contraindication	449868002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.23	acidic
pKa2	3.35	Basic
pKa3	2.72	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Potassium-transporting ATPase	Transporter	P20648 P51164	ATP4A_HUMAN ATP4B_HUMAN	INHIBITOR			CHEMBL	CHEMBL
Peptidyl-prolyl cis-trans isomerase A	Enzyme	P62937	PPIA_HUMAN		IC50	6.12	CHEMBL
ATP-binding cassette sub-family G member 2	Transporter	Q9UNQ0	ABCG2_HUMAN		IC50	4.84	CHEMBL
Cytochrome P450 2C19	Enzyme	P33261	CP2CJ_HUMAN		IC50	6.47	DRUG MATRIX
Fatty acid synthase	Enzyme	P49327	FAS_HUMAN		Ki	5.28	CHEMBL
Phosphoethanolamine/phosphocholine phosphatase	Enzyme	Q8TCT1	PHOP1_HUMAN		IC50	6.36	CHEMBL
Microtubule-associated protein tau	Structural	P10636	TAU_HUMAN		Ki	8.60	CHEMBL
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	Enzyme	O94760	DDAH1_HUMAN		IC50	4.29	CHEMBL
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	5.28	DRUG MATRIX
Cytosolic endo-beta-N-acetylglucosaminidase	Enzyme	Q8NFI3	ENASE_HUMAN		IC50	4.61	CHEMBL
Indoleamine 2,3-dioxygenase 2	Enzyme		I23O2_MOUSE		IC50	5.09	CHEMBL
Indoleamine 2,3-dioxygenase 1	Enzyme		I23O1_MOUSE		IC50	4.03	CHEMBL

External reference:

ID	Source
D00355	KEGG_DRUG
4020922	VANDF
C0050940	UMLSCUI
CHEMBL480	ChEMBL_ID
DB00448	DRUGBANK_ID
D064747	MESH_DESCRIPTOR_UI
3883	PUBCHEM_CID
7208	IUPHAR_LIGAND_ID
6397	INN_ID
0K5C5T2QPG	UNII
17128	RXNORM
169151	MMSL
330	MMSL
4958	MMSL
d03828	MMSL
004456	NDDF
108666007	SNOMEDCT_US
386888004	SNOMEDCT_US
CHEBI:6375	CHEBI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3008	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	15 mg	ORAL	ANDA	29 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-3009	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	30 mg	ORAL	ANDA	29 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7350	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	27 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7351	CAPSULE, DELAYED RELEASE	30 mg	ORAL	ANDA	27 sections
Good Sense Lansoprazole	HUMAN OTC DRUG LABEL	1	0113-0116	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	15 mg	ORAL	NDA	15 sections
Good Sense Lansoprazole	HUMAN OTC DRUG LABEL	1	0113-1114	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	15 sections
Prevacid 24 HR	HUMAN OTC DRUG LABEL	1	0113-6117	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	15 sections
Lansoprazole	HUMAN OTC DRUG LABEL	1	0363-0037	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	15 sections
lansoprazole	HUMAN OTC DRUG LABEL	1	0363-1212	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	15 sections
Lansoprazole	HUMAN OTC DRUG LABEL	1	0363-1419	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	15 mg	ORAL	NDA	15 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-6981	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	15 mg	ORAL	ANDA	28 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-6982	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	30 mg	ORAL	ANDA	28 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-8015	CAPSULE, DELAYED RELEASE PELLETS	15 mg	ORAL	ANDA	29 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0378-8030	CAPSULE, DELAYED RELEASE PELLETS	30 mg	ORAL	ANDA	29 sections
Lansoprazole	HUMAN OTC DRUG LABEL	1	0536-1368	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	15 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6662	CAPSULE, DELAYED RELEASE	30 mg	ORAL	ANDA	27 sections
up and up lansoprazole	HUMAN OTC DRUG LABEL	1	11673-280	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	15 sections
Lansoprazole	HUMAN OTC DRUG LABEL	1	11673-324	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	15 sections
Lansoprazole	HUMAN OTC DRUG LABEL	1	11822-0019	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	15 sections
Lansoprazole	HUMAN OTC DRUG LABEL	1	11822-3374	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	15 sections
Lansoprazole	Human Prescription Drug Label	1	16571-697	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	26 sections
Lansoprazole	Human Prescription Drug Label	1	16571-698	CAPSULE, DELAYED RELEASE	30 mg	ORAL	ANDA	26 sections
Lansoprazole	Human OTC Drug Label	1	16571-742	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	15 sections
LANSOPRAZOLE	HUMAN PRESCRIPTION DRUG LABEL	1	16590-890	CAPSULE, DELAYED RELEASE	15 mg	ORAL	NDA authorized generic	32 sections
LANSOPRAZOLE	HUMAN PRESCRIPTION DRUG LABEL	1	16590-891	CAPSULE, DELAYED RELEASE	30 mg	ORAL	NDA authorized generic	32 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	16714-185	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	15 mg	ORAL	ANDA	28 sections
Lansoprazole	HUMAN PRESCRIPTION DRUG LABEL	1	16714-186	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	30 mg	ORAL	ANDA	28 sections
Lansoprazole	HUMAN OTC DRUG LABEL	1	21130-019	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	15 sections
Lansoprazole	HUMAN OTC DRUG LABEL	1	21130-046	CAPSULE, DELAYED RELEASE	15 mg	ORAL	ANDA	15 sections
Prevacid SoluTab	HUMAN PRESCRIPTION DRUG LABEL	1	21695-106	TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE	30 mg	ORAL	NDA	32 sections

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lansoprazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: