omeprazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antiulcer, benzimidazole derivatives 1990 73590-58-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • omeprazole sodium
  • omeprazole
  • omeprazole magnesium
  • omeprazole sodium bicarbonate
A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
  • Molecular weight: 345.42
  • Formula: C17H19N3O3S
  • CLOGP: 2.56
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 77.10
  • ALOGS: -2.98
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O
20 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ
S (Water solubility) 0.02 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 5.79 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.24 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 8.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.05 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.58 hours Lombardo F, Berellini G, Obach RS
BA (Bioavailability) 53 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK1,GRK2,GSK3B,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAPK1,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 63
kinase-selectivity-class AXL,BRAF,GRK2,PDK4 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Sept. 14, 1989 FDA ASTRAZENECA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1766.53 9.27 29 530567 326835 89771016
Synovitis 1567.86 9.27 90 530506 329662 89768189
Hand deformity 1521.17 9.27 47 530549 296315 89801536
Systemic lupus erythematosus 1335.65 9.27 251 530345 361645 89736206
Anti-cyclic citrullinated peptide antibody positive 1312.32 9.27 13 530583 236420 89861431
Glossodynia 1295.80 9.27 175 530421 321604 89776247
Contraindicated product administered 1268.25 9.27 183 530413 319956 89777895
Drug intolerance 1191.07 9.27 566 530030 447025 89650826
Wound 1184.41 9.27 180 530416 302800 89795051
Duodenal ulcer perforation 1111.02 9.27 42 530554 221246 89876605
Hypomagnesaemia 1080.61 9.27 1183 529413 34405 90063446
Helicobacter infection 1019.24 9.27 82 530514 226768 89871083
Folliculitis 1008.34 9.27 44 530552 204309 89893542
Infusion related reaction 988.99 9.27 609 529987 416171 89681680
Pericarditis 984.48 9.27 193 530403 269958 89827893
Treatment failure 983.72 9.27 280 530316 303648 89794203
Rheumatoid factor positive 936.36 9.27 13 530583 171637 89926214
Muscle injury 924.67 9.27 23 530573 176631 89921220
Drug ineffective 871.96 9.27 4669 525927 1379629 88718222
Rheumatic fever 851.46 9.27 8 530588 153113 89944738
Drug interaction 846.96 9.27 3533 527063 272920 89824931
Hepatic enzyme increased 841.96 9.27 537 530059 360199 89737652
Maternal exposure during pregnancy 813.31 9.27 556 530040 359507 89738344
Chronic kidney disease 771.79 9.27 1192 529404 48999 90048852
Arthropathy 753.38 9.27 623 529973 365619 89732232
Acute kidney injury 751.42 9.27 3785 526811 316602 89781249
Hyponatraemia 745.58 9.27 2087 528509 131451 89966400
Therapeutic product effect decreased 700.19 9.27 376 530220 277195 89820656
Sleep disorder due to general medical condition, insomnia type 676.34 9.27 16 530580 128678 89969173
Joint swelling 660.75 9.27 1212 529384 502088 89595763
C-reactive protein abnormal 629.93 9.27 27 530569 127402 89970449
Impaired healing 622.46 9.27 296 530300 233903 89863948
Tubulointerstitial nephritis 622.09 9.27 755 529841 24588 90073263
Irritable bowel syndrome 617.89 9.27 221 530375 207227 89890624
Swollen joint count increased 599.70 9.27 10 530586 111196 89986655
Type 2 diabetes mellitus 597.76 9.27 221 530375 203023 89894828
Discomfort 597.70 9.27 440 530156 273895 89823956
Off label use 540.54 9.27 4011 526585 1098241 88999610
Liver injury 526.49 9.27 171 530425 170396 89927455
Swelling 518.43 9.27 1045 529551 418013 89679838
Alopecia 505.54 9.27 1368 529228 493703 89604148
Product use issue 497.50 9.27 725 529871 329194 89768657
Psoriatic arthropathy 492.42 9.27 370 530226 227965 89869886
Ill-defined disorder 474.12 9.27 245 530351 184646 89913205
Hypersensitivity 473.52 9.27 1244 529352 453433 89644418
Joint range of motion decreased 455.43 9.27 116 530480 135527 89962324
Abdominal discomfort 452.02 9.27 1367 529229 475961 89621890
Lip dry 449.06 9.27 38 530558 100917 89996934
Facet joint syndrome 448.94 9.27 33 530563 98356 89999495
Drug hypersensitivity 435.90 9.27 1332 529264 462277 89635574
Hypocalcaemia 420.84 9.27 830 529766 41538 90056313
Breast cancer stage III 401.06 9.27 23 530573 84424 90013427
Fibromyalgia 383.15 9.27 385 530211 205884 89891967
Blister 379.74 9.27 565 530031 254433 89843418
Rheumatoid arthritis 375.89 9.27 994 529602 361620 89736231
Stomatitis 368.45 9.27 652 529944 274046 89823805
Diarrhoea 365.54 9.27 7609 522987 931581 89166270
Grip strength decreased 352.37 9.27 59 530537 92517 90005334
Fall 346.83 9.27 4326 526270 477484 89620367
Bursitis 341.14 9.27 172 530424 131482 89966369
Blood cholesterol increased 339.73 9.27 431 530165 207581 89890270
Subacute cutaneous lupus erythematosus 332.30 9.27 226 530370 3356 90094495
Constipation 325.68 9.27 2777 527819 277618 89820233
Musculoskeletal stiffness 323.35 9.27 792 529804 295740 89802111
General physical health deterioration 316.22 9.27 1045 529551 354070 89743781
Wound infection 315.59 9.27 114 530482 106288 89991563
Peripheral venous disease 311.72 9.27 57 530539 83864 90013987
Exposure during pregnancy 308.84 9.27 578 530018 237832 89860019
Hypokalaemia 308.10 9.27 1551 529045 129565 89968286
Balance disorder 305.55 9.27 1252 529344 95828 90002023
Orthostatic hypotension 301.60 9.27 720 529876 41107 90056744
Deep vein thrombosis postoperative 298.18 9.27 33 530563 70776 90027075
Therapeutic product effect incomplete 288.23 9.27 430 530166 193466 89904385
Prescribed overdose 285.48 9.27 107 530489 97518 90000333
Live birth 280.67 9.27 60 530536 79047 90018804
Hypercholesterolaemia 276.47 9.27 122 530474 100770 89997081
Renal injury 270.86 9.27 317 530279 9926 90087925
Autoimmune disorder 268.65 9.27 60 530536 76684 90021167
Infection 265.62 9.27 1153 529443 360941 89736910
Adjustment disorder with depressed mood 264.83 9.27 17 530579 56736 90041115
Injury 263.10 9.27 470 530126 196879 89900972
Intentional product use issue 260.12 9.27 550 530046 216342 89881509
Cognitive disorder 258.33 9.27 944 529652 68463 90029388
Blood calcium decreased 255.89 9.27 554 530042 29628 90068223
Creatinine renal clearance decreased 253.65 9.27 422 530174 18477 90079374
Lower respiratory tract infection 246.95 9.27 704 529892 249955 89847896
Dislocation of vertebra 238.43 9.27 25 530571 55943 90041908
Gastrointestinal disorder 236.99 9.27 743 529853 255944 89841907
Lupus vulgaris 235.17 9.27 6 530590 45053 90052798
Dehydration 227.29 9.27 1929 528667 192518 89905333
X-ray abnormal 226.53 9.27 9 530587 45415 90052436
Urinary tract infection 222.03 9.27 2750 527846 302882 89794969
Sedation complication 218.96 9.27 372 530224 16572 90081279
Blepharospasm 218.55 9.27 32 530564 55413 90042438
Nasopharyngitis 213.64 9.27 1450 529146 405654 89692197
Nausea 211.06 9.27 8214 522382 1102102 88995749
Inflammation 208.20 9.27 460 530136 178132 89919719
Wheezing 206.72 9.27 708 529888 237372 89860479
Bone erosion 194.79 9.27 37 530559 52984 90044867
Retinitis 187.23 9.27 9 530587 38449 90059402
Sciatica 183.88 9.27 193 530403 101189 89996662
Pulmonary fibrosis 183.62 9.27 215 530381 107288 89990563
End stage renal disease 182.70 9.27 238 530358 8333 90089518
Obesity 181.29 9.27 210 530386 105297 89992554
C-reactive protein increased 179.66 9.27 508 530088 180881 89916970
Hypotension 172.29 9.27 2769 527827 322628 89775223
Renal failure 172.16 9.27 1335 529261 129672 89968179
Condition aggravated 172.13 9.27 2453 528143 593092 89504759
Cholecystitis chronic 171.93 9.27 248 530348 9578 90088273
C-reactive protein 168.33 9.27 3 530593 31364 90066487
Lung disorder 168.24 9.27 394 530202 149489 89948362
Anaemia 165.56 9.27 2944 527652 349858 89747993
Lower limb fracture 165.54 9.27 152 530444 84861 90012990
Red blood cell sedimentation rate increased 165.24 9.27 144 530452 82451 90015400
Night sweats 164.17 9.27 315 530281 128451 89969400
Onychomadesis 162.94 9.27 35 530561 45963 90051888
Prescribed underdose 159.75 9.27 123 530473 74896 90022955
Gait inability 159.62 9.27 391 530205 146065 89951786
Gastrointestinal haemorrhage 158.32 9.27 987 529609 89261 90008590
Adverse event 157.01 9.27 279 530317 117139 89980712
Plasma cell myeloma 155.03 9.27 559 530037 40269 90057582
Lip swelling 153.78 9.27 537 530059 38073 90059778
Therapy non-responder 152.12 9.27 361 530235 136343 89961508
Abdominal pain 151.35 9.27 3201 527395 392520 89705331
Sleep disorder 149.72 9.27 623 529973 197407 89900444
Osteoarthritis 147.83 9.27 616 529980 195114 89902737
Hip arthroplasty 147.50 9.27 137 530459 76071 90021780
Vision blurred 147.17 9.27 1128 529468 109165 89988686
Sedation 146.60 9.27 615 529981 47556 90050295
Weight increased 144.93 9.27 1656 528940 416271 89681580
Myalgia 142.59 9.27 1611 528985 173514 89924337
Syncope 141.94 9.27 1291 529305 131372 89966479
Road traffic accident 141.86 9.27 258 530338 107368 89990483
Tremor 140.94 9.27 1444 529152 151729 89946122
Drug tolerance decreased 140.40 9.27 13 530583 32117 90065734
Nail disorder 138.82 9.27 87 530509 58980 90038871
Gastritis 135.70 9.27 544 530052 41209 90056642
Back pain 135.29 9.27 2608 527988 314567 89783284
Pulmonary embolism 133.38 9.27 1260 529336 129560 89968291
Atrial fibrillation 132.81 9.27 1280 529316 132331 89965520
Breast cancer stage II 131.20 9.27 24 530572 35310 90062541
Product dose omission issue 130.44 9.27 2416 528180 289271 89808580
Rash 129.84 9.27 3609 526987 792491 89305360
Feeling abnormal 128.80 9.27 1522 529074 165713 89932138
Hallucination 126.92 9.27 739 529857 65220 90032631
Lethargy 125.80 9.27 714 529882 62425 90035426
Haematemesis 124.86 9.27 458 530138 33268 90064583
Liver disorder 124.25 9.27 334 530262 120935 89976916
Dyspnoea 124.02 9.27 6323 524273 874632 89223219
Pregnancy 121.91 9.27 110 530486 61937 90035914
Transient ischaemic attack 119.72 9.27 536 530060 42640 90055211
Musculoskeletal pain 119.58 9.27 555 530041 170696 89927155
Palpitations 117.79 9.27 1272 529324 135456 89962395
Liver function test abnormal 117.61 9.27 599 529997 50246 90047605
Coeliac disease 117.45 9.27 57 530539 44553 90053298
Deep vein thrombosis 116.13 9.27 926 529670 90694 90007157
International normalised ratio increased 114.80 9.27 565 530031 46751 90051100
Epilepsy 114.77 9.27 190 530406 82016 90015835
Finger deformity 112.58 9.27 27 530569 32870 90064981
Sinusitis 112.51 9.27 1376 529220 341712 89756139
Product use in unapproved indication 111.98 9.27 1344 529252 334892 89762959
Dizziness 111.68 9.27 4361 526235 584923 89512928
Tetany 111.63 9.27 104 530492 2480 90095371
Haemoglobin decreased 111.37 9.27 1443 529153 160513 89937338
Pancreatitis acute 111.31 9.27 427 530169 31688 90066163
Disorientation 110.78 9.27 532 530064 43582 90054269
Sepsis 109.29 9.27 1567 529029 178247 89919604
Chronic obstructive pulmonary disease 107.53 9.27 771 529825 73058 90024793
Vomiting 107.19 9.27 5640 524956 782653 89315198
Back injury 106.38 9.27 71 530525 46551 90051300
Red blood cell sedimentation rate abnormal 105.21 9.27 10 530586 24194 90073657
Mobility decreased 104.37 9.27 951 529645 249783 89848068
Exostosis 103.44 9.27 95 530501 53039 90044812
Cough 103.26 9.27 2860 527736 366102 89731749
Hiatus hernia 102.96 9.27 355 530241 25006 90072845
Rhabdomyolysis 101.70 9.27 579 530017 50677 90047174
Onychomycosis 99.56 9.27 47 530549 37329 90060522
Hypoaesthesia 98.96 9.27 1271 529325 312939 89784912
Maternal exposure timing unspecified 98.50 9.27 9 530587 22474 90075377
Liver function test increased 98.48 9.27 219 530377 84636 90013215
Tinnitus 97.75 9.27 505 530091 42597 90055254
Peripheral swelling 97.64 9.27 1766 528830 411340 89686511
Taste disorder 94.82 9.27 133 530463 61413 90036438
Infective pulmonary exacerbation of cystic fibrosis 93.28 9.27 194 530402 10085 90087766
Oedema 93.08 9.27 738 529858 199557 89898294
Hypoparathyroidism 92.48 9.27 63 530533 938 90096913
Flatulence 91.28 9.27 481 530115 40886 90056965
Hypertensive nephropathy 88.33 9.27 53 530543 625 90097226
Inappropriate antidiuretic hormone secretion 88.06 9.27 283 530313 19222 90078629
Swollen tongue 87.83 9.27 514 530082 45442 90052409
Knee arthroplasty 86.03 9.27 228 530368 82954 90014897
Cogwheel rigidity 85.83 9.27 82 530514 2020 90095831
Depressed level of consciousness 84.91 9.27 722 529874 72062 90025789
Gastric pH decreased 83.92 9.27 59 530537 927 90096924
Urticaria 83.62 9.27 1307 529289 311427 89786424
Chest discomfort 82.94 9.27 1203 529393 137162 89960689
Disturbance in attention 82.46 9.27 515 530081 46594 90051257
Gastric polyps 81.86 9.27 118 530478 4554 90093297
Angioedema 81.82 9.27 655 529941 64221 90033630
Cerebrovascular accident 81.71 9.27 1093 529503 122440 89975411
Gallbladder disorder 81.09 9.27 278 530318 19525 90078326
Hypoglycaemia 81.02 9.27 692 529904 69156 90028695
Seronegative arthritis 80.69 9.27 7 530589 18227 90079624
Porphyria acute 79.27 9.27 7 530589 17968 90079883
Urinary retention 78.62 9.27 432 530164 37312 90060539
Walking aid user 78.45 9.27 56 530540 35450 90062401
Swelling face 77.70 9.27 773 529823 80579 90017272
Asthenia 77.52 9.27 3844 526752 529907 89567944
Myelosuppression 76.55 9.27 122 530474 53469 90044382
Blood sodium decreased 75.95 9.27 342 530254 27271 90070580
Laryngitis 73.01 9.27 115 530481 50638 90047213
Toxic epidermal necrolysis 71.61 9.27 378 530218 32150 90065701
Electrocardiogram QT prolonged 71.41 9.27 693 529903 71763 90026088
Agitation 71.24 9.27 652 529944 66446 90031405
Parkinsonism 69.90 9.27 211 530385 13854 90083997
Dysgeusia 69.78 9.27 537 530059 52023 90045828
Drug ineffective for unapproved indication 69.43 9.27 182 530414 66462 90031389
Macular degeneration 69.15 9.27 72 530524 37898 90059953
Feeling of despair 68.34 9.27 89 530507 3115 90094736
Blood alkaline phosphatase increased 68.22 9.27 499 530097 47580 90050271
Hypertension 68.13 9.27 2099 528497 455433 89642418
Rheumatoid nodule 68.13 9.27 17 530579 20149 90077702
Drug resistance 67.30 9.27 48 530548 30401 90067450
Somnolence 67.21 9.27 1651 528945 207433 89890418
Dry skin 67.08 9.27 800 529796 87273 90010578
Oesophagitis 67.04 9.27 238 530358 17011 90080840
Nightmare 66.59 9.27 278 530318 21447 90076404
Subcutaneous drug absorption impaired 66.48 9.27 3 530593 13542 90084309
Joint dislocation 66.06 9.27 99 530497 44483 90053368
Dysphagia 66.03 9.27 973 529623 111305 89986546
Vertigo 66.02 9.27 662 529934 69149 90028702
Normal newborn 65.98 9.27 27 530569 23335 90074516
Adverse reaction 65.46 9.27 47 530549 29665 90068186
Hip fracture 65.19 9.27 373 530223 32704 90065147
Carotid artery occlusion 65.09 9.27 126 530470 6216 90091635
Melaena 64.44 9.27 386 530210 34411 90063440
Upper gastrointestinal haemorrhage 63.52 9.27 285 530311 22691 90075160
Hyperkalaemia 62.87 9.27 619 529977 64345 90033506
Drug-induced liver injury 62.85 9.27 293 530303 90025 90007826
Subarachnoid haemorrhage 62.82 9.27 239 530357 17665 90080186
Metabolic alkalosis 62.72 9.27 90 530506 3459 90094392
Tension headache 62.69 9.27 137 530459 7372 90090479
Joint stiffness 62.43 9.27 240 530356 77802 90020049
Cardiospasm 61.79 9.27 88 530508 3358 90094493
Myocardial infarction 61.78 9.27 917 529679 105055 89992796
Pruritus genital 61.46 9.27 102 530494 4456 90093395
Hyperhidrosis 60.84 9.27 1129 529467 135176 89962675
Infusion site reaction 60.65 9.27 18 530578 19021 90078830
Palmoplantar keratoderma 60.61 9.27 88 530508 3419 90094432
Device expulsion 60.38 9.27 91 530505 40795 90057056
Neutropenic sepsis 60.34 9.27 238 530358 17892 90079959
Atrial tachycardia 60.25 9.27 118 530478 5872 90091979
Depersonalisation/derealisation disorder 59.80 9.27 60 530536 1572 90096279
Pain 59.39 9.27 5025 525571 991316 89106535
Seizure 58.32 9.27 1235 529361 151394 89946457
Biliary dyskinesia 58.27 9.27 74 530522 2525 90095326
Impaired quality of life 58.03 9.27 279 530317 22865 90074986
Disability 57.03 9.27 94 530502 40651 90057200
Hypophosphataemia 56.91 9.27 204 530392 14650 90083201
Completed suicide 56.56 9.27 559 530037 144499 89953352
Restless legs syndrome 56.43 9.27 271 530325 22199 90075652
Hepatic cirrhosis 56.27 9.27 186 530410 63067 90034784
Malaise 55.70 9.27 4065 526531 581921 89515930
Cardiac failure congestive 55.58 9.27 849 529747 97845 90000006
Foot deformity 55.45 9.27 172 530424 59479 90038372
Abdominal tenderness 55.21 9.27 149 530447 9175 90088676
Emotional distress 55.20 9.27 386 530210 36276 90061575
Femur fracture 54.74 9.27 459 530137 45623 90052228
Blood magnesium decreased 54.66 9.27 209 530387 15484 90082367
Lipase increased 54.57 9.27 166 530430 10945 90086906
Blood potassium decreased 54.38 9.27 471 530125 47256 90050595
Epistaxis 54.16 9.27 748 529848 84377 90013474
Chills 54.07 9.27 1079 529517 130902 89966949
Bone pain 53.98 9.27 578 530018 61405 90036446
Electrolyte imbalance 53.70 9.27 278 530318 23467 90074384
Hallucinations, mixed 53.27 9.27 111 530485 5778 90092073
Proctitis 53.25 9.27 12 530584 15247 90082604
Cellulitis 52.71 9.27 789 529807 90548 90007303
Frequent bowel movements 52.33 9.27 165 530431 56770 90041081
Mania 51.60 9.27 191 530405 13933 90083918
Therapeutic response decreased 51.34 9.27 311 530285 89418 90008433
Clostridium difficile infection 51.32 9.27 376 530220 35869 90061982
Parosmia 51.28 9.27 122 530474 6947 90090904
H1N1 influenza 51.15 9.27 61 530535 1949 90095902
Contusion 51.09 9.27 1101 529495 250115 89847736
Blood urea increased 50.46 9.27 328 530268 30085 90067766
Sleep terror 49.92 9.27 92 530504 4372 90093479
Skin discolouration 49.80 9.27 436 530160 43879 90053972
Pulmonary malformation 49.55 9.27 30 530566 360 90097491
Atrioventricular block first degree 49.39 9.27 135 530461 8376 90089475
Acute respiratory failure 49.14 9.27 424 530172 42494 90055357
Cholecystitis 49.10 9.27 214 530382 16826 90081025
Muscle rigidity 48.56 9.27 189 530407 14120 90083731
Oral pain 48.56 9.27 343 530253 32340 90065511
Faeces discoloured 48.48 9.27 250 530346 21070 90076781
Dementia 48.29 9.27 271 530325 23590 90074261
Ventricular tachycardia 48.28 9.27 278 530318 24430 90073421
Foetal death 48.03 9.27 31 530565 20692 90077159
Product substitution issue 48.01 9.27 221 530375 17787 90080064
Derealisation 47.92 9.27 51 530545 1434 90096417
Temperature regulation disorder 47.90 9.27 13 530583 14566 90083285
Cholelithiasis 47.78 9.27 494 530102 52012 90045839
Incorrect route of product administration 47.75 9.27 145 530451 50481 90047370
Dysuria 47.09 9.27 393 530203 39008 90058843
Loss of consciousness 47.05 9.27 1114 529482 139124 89958727
Mouth swelling 46.93 9.27 103 530493 5559 90092292
Atrioventricular block complete 46.72 9.27 145 530451 9666 90088185
Underdose 46.58 9.27 161 530435 53856 90043995
Stevens-Johnson syndrome 46.43 9.27 313 530283 29063 90068788
Speech disorder 45.41 9.27 437 530159 45148 90052703
Nervousness 45.23 9.27 348 530248 33708 90064143
Cystic fibrosis 45.06 9.27 82 530514 3859 90093992
Product formulation issue 44.93 9.27 35 530561 648 90097203
Diabetic nephropathy 44.74 9.27 53 530543 1681 90096170
Immunodeficiency 44.32 9.27 119 530477 43115 90054736
Hypoaesthesia oral 44.25 9.27 195 530401 15405 90082446
Thrombosis 43.92 9.27 637 529959 72614 90025237
Facial pain 43.83 9.27 173 530423 13009 90084842
Joint destruction 43.37 9.27 12 530584 13275 90084576
Presyncope 43.36 9.27 327 530269 31478 90066373
General symptom 43.00 9.27 16 530580 14652 90083199
Hypertrichosis 42.87 9.27 48 530548 1431 90096420
Cross sensitivity reaction 42.70 9.27 67 530529 2790 90095061
Illness 42.70 9.27 696 529900 81273 90016578
Feeling of body temperature change 42.62 9.27 99 530497 5550 90092301
Blood glucose increased 42.17 9.27 788 529808 94458 90003393
Cholecystectomy 42.14 9.27 158 530438 11597 90086254
Burning mouth syndrome 42.07 9.27 32 530564 571 90097280
Arthralgia 41.83 9.27 3957 526639 774565 89323286
Rebound acid hypersecretion 41.43 9.27 26 530570 334 90097517
Diplopia 41.30 9.27 299 530297 28415 90069436
Tenosynovitis 40.87 9.27 17 530579 14550 90083301
Urinary incontinence 40.87 9.27 367 530229 37199 90060652
Gallbladder injury 40.65 9.27 44 530552 1262 90096589
Anxiety 40.62 9.27 2210 528386 307562 89790289
Mood swings 40.50 9.27 233 530363 20469 90077382
Small intestinal obstruction 40.25 9.27 237 530359 20997 90076854
Abortion spontaneous 40.23 9.27 171 530425 53885 90043966
Pustular psoriasis 40.04 9.27 30 530566 18526 90079325
Jaundice 39.75 9.27 326 530270 32191 90065660
Female genital tract fistula 39.71 9.27 28 530568 17840 90080011
Renal impairment 39.61 9.27 851 529745 104570 89993281
Muscle twitching 39.53 9.27 260 530336 23942 90073909
Abnormal loss of weight 39.37 9.27 108 530488 6715 90091136
Malabsorption 39.35 9.27 91 530505 5087 90092764
Oropharyngeal pain 38.94 9.27 916 529680 114271 89983580
Chromaturia 38.88 9.27 218 530378 18969 90078882
Dermatitis atopic 38.85 9.27 253 530343 23219 90074632
Muscle spasticity 38.70 9.27 94 530502 35228 90062623
Lupus-like syndrome 38.56 9.27 151 530445 48695 90049156
Pancytopenia 38.13 9.27 948 529648 119315 89978536
Muscle disorder 38.07 9.27 93 530503 5386 90092465
Drooling 38.02 9.27 83 530513 4463 90093388
Emotional disorder 37.75 9.27 181 530415 14816 90083035
Pneumonitis 37.58 9.27 410 530186 43760 90054091
Spondylitis 37.50 9.27 18 530578 14160 90083691
Abdominal distension 37.48 9.27 1016 529580 129585 89968266
Pulmonary pain 36.82 9.27 88 530508 5026 90092825
Respiratory failure 36.81 9.27 931 529665 117487 89980364
Tachycardia 36.67 9.27 1195 529401 156478 89941373
Anosmia 36.67 9.27 134 530462 9714 90088137
Multiple drug therapy 36.59 9.27 107 530489 6902 90090949
Abnormal behaviour 36.30 9.27 242 530354 22386 90075465
Malignant mediastinal neoplasm 36.27 9.27 43 530553 1365 90096486
Loss of personal independence in daily activities 36.27 9.27 569 530027 135536 89962315
Serotonin syndrome 36.17 9.27 360 530236 37527 90060324
Immunisation 36.04 9.27 54 530542 2159 90095692
Eosinophilic oesophagitis 35.94 9.27 34 530562 827 90097024
Heart rate increased 35.80 9.27 890 529706 112012 89985839
Iron deficiency anaemia 35.55 9.27 249 530347 23413 90074438
Dilatation intrahepatic duct acquired 35.30 9.27 32 530564 736 90097115
Torus fracture 35.21 9.27 18 530578 151 90097700
Genital blister 35.21 9.27 18 530578 151 90097700
Cerebellar syndrome 35.04 9.27 73 530523 3799 90094052
Calcium deficiency 34.82 9.27 41 530555 1292 90096559
Blood pressure diastolic abnormal 34.76 9.27 39 530557 19842 90078009
Ulcer haemorrhage 34.76 9.27 63 530533 26258 90071593
Burning sensation 34.64 9.27 543 530053 62909 90034942
Blood pressure systolic increased 34.55 9.27 200 530396 58145 90039706
Duodenal stenosis 34.49 9.27 29 530567 601 90097250
Circulatory collapse 34.49 9.27 257 530339 24647 90073204
Full blood count decreased 34.35 9.27 294 530302 29395 90068456
Nephrogenic anaemia 34.35 9.27 56 530540 2410 90095441
Suicidal ideation 34.08 9.27 615 529981 73240 90024611
Rash macular 34.07 9.27 298 530298 29982 90067869
Diverticulum 34.04 9.27 151 530445 11962 90085889
Respiratory tract malformation 33.86 9.27 18 530578 165 90097686
Acute myocardial infarction 33.54 9.27 332 530264 34558 90063293
Rash papular 33.45 9.27 219 530377 20136 90077715
Blindness 33.36 9.27 268 530328 26300 90071551
Influenza 33.04 9.27 1058 529538 138206 89959645
Chest pain 32.83 9.27 2232 528364 317413 89780438
Hypergammaglobulinaemia 32.80 9.27 28 530568 593 90097258
Palatal oedema 32.61 9.27 29 530567 650 90097201
Large intestine infection 32.58 9.27 57 530539 2600 90095251
Essential hypertension 32.58 9.27 96 530500 6219 90091632
Hot flush 32.06 9.27 508 530088 58980 90038871
Muscle spasms 32.02 9.27 1792 528804 250091 89847760
Chronic spontaneous urticaria 31.94 9.27 46 530550 1774 90096077
Respiratory disorder 31.88 9.27 235 530361 64581 90033270
Platelet count decreased 31.83 9.27 1038 529558 135931 89961920
Drug dispensed to wrong patient 31.76 9.27 22 530574 337 90097514
Hypophagia 31.70 9.27 336 530260 35601 90062250
Non-cardiac chest pain 31.70 9.27 99 530497 6622 90091229
Surgery 31.69 9.27 402 530194 44485 90053366
Panniculitis 31.68 9.27 23 530573 14435 90083416
Incontinence 31.57 9.27 159 530437 13276 90084575
Gastroenteritis 31.51 9.27 285 530311 28944 90068907
Head discomfort 31.41 9.27 183 530413 16150 90081701
Adverse drug reaction 31.39 9.27 487 530109 116214 89981637
Injection site reaction 31.39 9.27 366 530230 91714 90006137
Hyperreflexia 31.34 9.27 98 530498 6559 90091292
Intestinal obstruction 31.28 9.27 344 530252 36787 90061064
Delirium 31.03 9.27 427 530169 103932 89993919
Dry mouth 30.97 9.27 830 529766 183229 89914622
International normalised ratio abnormal 30.80 9.27 69 530527 3776 90094075
Hypoparathyroidism secondary 30.72 9.27 12 530584 48 90097803
Poisoning deliberate 30.32 9.27 31 530565 16455 90081396
Bradycardia 30.27 9.27 673 529923 83174 90014677
Amyloid arthropathy 30.27 9.27 43 530553 1637 90096214
Intestinal dilatation 30.22 9.27 51 530545 2259 90095592
Dyskinesia 30.11 9.27 337 530259 36197 90061654
Aphasia 30.05 9.27 383 530213 42429 90055422
Pallor 29.93 9.27 319 530277 33846 90064005
Lower gastrointestinal haemorrhage 29.81 9.27 117 530479 8775 90089076
Nephropathy 29.74 9.27 120 530476 9115 90088736
Migraine 29.62 9.27 868 529728 189524 89908327
Mouth ulceration 29.51 9.27 361 530235 39613 90058238
Dialysis 29.44 9.27 138 530458 11191 90086660
Skin exfoliation 29.42 9.27 560 530036 67353 90030498
Ear infection 29.28 9.27 264 530332 69511 90028340
Hypervolaemia 29.24 9.27 307 530289 32450 90065401
Vitamin D deficiency 28.91 9.27 189 530407 17367 90080484
Eye pruritus 28.77 9.27 278 530318 28749 90069102
Acute generalised exanthematous pustulosis 28.64 9.27 157 530439 13546 90084305
Hallucination, visual 28.49 9.27 232 530364 22860 90074991
Pulmonary toxicity 28.48 9.27 16 530580 11515 90086336
Lung cyst 28.37 9.27 23 530573 452 90097399
Haematuria 28.22 9.27 321 530275 34616 90063235
Blood creatine phosphokinase increased 28.11 9.27 314 530282 33709 90064142
Irritability 28.06 9.27 326 530270 35336 90062515
Product blister packaging issue 28.03 9.27 20 530576 322 90097529
Vitamin B12 deficiency 27.99 9.27 102 530494 7384 90090467
Chronic sinusitis 27.96 9.27 61 530535 23741 90074110
Malnutrition 27.71 9.27 195 530401 18363 90079488
Ear pain 27.53 9.27 211 530385 57491 90040360
Mood altered 27.29 9.27 183 530413 16961 90080890
Pneumonia 27.12 9.27 4193 526403 633866 89463985
Tongue blistering 27.12 9.27 44 530552 1886 90095965
Death 27.04 9.27 3061 527535 453490 89644361
Pain of skin 27.02 9.27 174 530422 15908 90081943
Food allergy 26.98 9.27 69 530527 25409 90072442
Cholestasis 26.88 9.27 328 530268 35971 90061880
Goitre 26.84 9.27 94 530502 6673 90091178
Head injury 26.76 9.27 290 530306 30898 90066953
Hyperbilirubinaemia 26.71 9.27 156 530440 13780 90084071
Cyanosis 26.51 9.27 200 530396 19255 90078596
Nephritis allergic 26.36 9.27 19 530577 311 90097540
Renal disorder 26.28 9.27 338 530258 37521 90060330
Cholecystitis acute 26.26 9.27 117 530479 9287 90088564
Vaginal discharge 26.23 9.27 46 530550 19418 90078433
Congenital thrombocytopenia 26.22 9.27 11 530585 55 90097796
Colitis ulcerative 26.18 9.27 226 530370 60040 90037811
Initial insomnia 26.12 9.27 116 530480 9194 90088657
Haemorrhoids 26.11 9.27 255 530341 26447 90071404
Drug reaction with eosinophilia and systemic symptoms 26.10 9.27 373 530223 42385 90055466
Eye pain 26.05 9.27 383 530213 43785 90054066
Pancreatitis 26.01 9.27 563 530033 69263 90028588
Ventilation perfusion mismatch 25.91 9.27 24 530572 568 90097283
Vasculitis 25.88 9.27 224 530372 22469 90075382
Prescription drug used without a prescription 25.61 9.27 58 530538 3197 90094654
Overlap syndrome 25.61 9.27 9 530587 8539 90089312
Hyperchlorhydria 25.59 9.27 43 530553 1898 90095953
Dysphonia 25.57 9.27 515 530081 62569 90035282
Oesophageal disorder 25.56 9.27 52 530544 2661 90095190
Drug withdrawal syndrome 25.54 9.27 269 530327 28454 90069397
Panic attack 25.40 9.27 251 530345 26114 90071737
Blood pressure systolic abnormal 25.38 9.27 47 530549 19431 90078420
Nephroangiosclerosis 25.27 9.27 16 530580 209 90097642
Labelled drug-drug interaction medication error 25.26 9.27 159 530437 14423 90083428
Pelvic fracture 25.16 9.27 164 530432 15055 90082796
Anal incontinence 25.09 9.27 172 530424 16058 90081793
Feeling jittery 25.03 9.27 165 530431 15206 90082645
Hyperlipidaemia 24.99 9.27 224 530372 22692 90075159
Depression 24.97 9.27 2064 528532 298537 89799314
Abnormal dreams 24.90 9.27 131 530465 11126 90086725
Eye injury 24.85 9.27 17 530579 11003 90086848
Hyperglycaemia 24.79 9.27 428 530168 50542 90047309
Haematoma 24.78 9.27 343 530253 38705 90059146
Premature delivery 24.52 9.27 130 530466 38632 90059219
Hepatic encephalopathy 24.37 9.27 151 530445 13621 90084230
Gastrointestinal sounds abnormal 24.34 9.27 70 530526 4473 90093378
Coronary artery disease 24.11 9.27 302 530294 33321 90064530
Acidosis 24.04 9.27 142 530454 12594 90085257
Skin test positive 24.04 9.27 28 530568 872 90096979
Diverticulitis 24.02 9.27 385 530211 44802 90053049
Supraventricular tachycardia 24.01 9.27 171 530425 16165 90081686
Oral mucosal blistering 23.94 9.27 92 530504 6832 90091019
Hypoacusis 23.92 9.27 259 530337 27591 90070260
Cutaneous lupus erythematosus 23.92 9.27 55 530541 3063 90094788
Spinal fracture 23.90 9.27 215 530381 21801 90076050
Oral discomfort 23.89 9.27 123 530473 10360 90087491
Skin necrosis 23.78 9.27 39 530557 16902 90080949
Hypergastrinaemia 23.66 9.27 13 530583 128 90097723
Haemorrhage intracranial 23.63 9.27 161 530435 15001 90082850
Pulmonary hypertension 23.63 9.27 365 530231 42158 90055693
Multiple-drug resistance 23.62 9.27 8 530588 7768 90090083
Tongue oedema 23.60 9.27 78 530518 5376 90092475
Drug tolerance 23.55 9.27 43 530553 17873 90079978
Neutrophil count increased 23.49 9.27 194 530402 19196 90078655
Hypernatraemia 23.41 9.27 113 530483 9274 90088577
Long QT syndrome 23.39 9.27 64 530532 3973 90093878
Duodenitis 23.15 9.27 67 530529 4296 90093555
Therapy partial responder 23.11 9.27 60 530536 21983 90075868
Aphonia 23.03 9.27 137 530459 12182 90085669
Impaired gastric emptying 23.02 9.27 141 530455 12668 90085183
Polyuria 23.02 9.27 118 530478 9922 90087929
Intestinal ischaemia 22.93 9.27 108 530488 8775 90089076
Limb reduction defect 22.85 9.27 23 530573 605 90097246
Adjusted calcium decreased 22.62 9.27 15 530581 213 90097638
Tongue discomfort 22.58 9.27 50 530546 2715 90095136
Blood immunoglobulin E increased 22.57 9.27 67 530529 4358 90093493
Truncus coeliacus thrombosis 22.48 9.27 7 530589 11 90097840
Rotator cuff syndrome 22.45 9.27 165 530431 15754 90082097
Therapeutic product ineffective 22.42 9.27 46 530550 2368 90095483
Alanine aminotransferase increased 22.36 9.27 876 529720 117462 89980389
Neuropathy peripheral 22.27 9.27 998 529598 135972 89961879
Moraxella test positive 22.22 9.27 8 530588 24 90097827
Device difficult to use 22.21 9.27 43 530553 17482 90080369
Dyspnoea exertional 22.07 9.27 567 530029 71721 90026130
Target skin lesion 22.03 9.27 12 530584 116 90097735
Product complaint 22.03 9.27 145 530451 13355 90084496
Blood creatinine increased 21.94 9.27 762 529834 100624 89997227
Bradykinesia 21.70 9.27 88 530508 6700 90091151
Nephrolithiasis 21.69 9.27 406 530190 48679 90049172
Haemoptysis 21.68 9.27 294 530302 33026 90064825
Throat tightness 21.65 9.27 266 530330 29218 90068633
White blood cell count decreased 21.64 9.27 1191 529405 165918 89931933
Thermohypoaesthesia 21.60 9.27 12 530584 121 90097730
Occult blood positive 21.56 9.27 62 530534 3961 90093890
Headache 21.42 9.27 5521 525075 857225 89240626
Insulin autoimmune syndrome 21.40 9.27 13 530583 157 90097694
Pneumonia streptococcal 21.32 9.27 42 530554 2099 90095752
Renal cyst 21.08 9.27 139 530457 12811 90085040
Colitis ischaemic 21 9.27 134 530462 12212 90085639
Clostridium difficile colitis 20.95 9.27 244 530352 26462 90071389
Hepatic failure 20.93 9.27 338 530258 39390 90058461
Therapy cessation 20.93 9.27 314 530282 36047 90061804
Bronchospasm 20.85 9.27 199 530397 20510 90077341
Viral diarrhoea 20.81 9.27 14 530582 204 90097647
Cardiac failure 20.79 9.27 811 529785 108685 89989166
Maternal exposure before pregnancy 20.71 9.27 21 530575 11192 90086659
Catatonia 20.66 9.27 5 530591 6051 90091800
Crohn's disease 20.65 9.27 69 530527 4782 90093069
Mucosal erosion 20.60 9.27 38 530558 1807 90096044
Subdural haemorrhage 20.57 9.27 55 530541 3368 90094483
Peripheral circulatory failure 20.44 9.27 35 530561 1569 90096282
Malignant neoplasm progression 20.38 9.27 473 530123 106397 89991454
Product quality issue 20.33 9.27 334 530262 78991 90018860
Eructation 20.33 9.27 121 530475 10761 90087090
Rash vesicular 20.27 9.27 48 530548 18149 90079702
Drug dose omission by device 20.26 9.27 18 530578 10213 90087638
Biliary colic 20.23 9.27 61 530535 4002 90093849
Breast cancer stage I 20.20 9.27 16 530580 9608 90088243
Haemodialysis 20.19 9.27 103 530493 8644 90089207
Eye irritation 20.18 9.27 295 530301 33683 90064168
Eyelid retraction 20.17 9.27 10 530586 78 90097773
Pharyngeal swelling 20.16 9.27 113 530483 9831 90088020
Endocrine ophthalmopathy 20.11 9.27 28 530568 1046 90096805
Bicytopenia 20.10 9.27 58 530538 3713 90094138
Ageusia 20.10 9.27 162 530434 15914 90081937
Product packaging confusion 19.96 9.27 14 530582 219 90097632
Spondylolysis 19.89 9.27 12 530584 143 90097708
Sight disability 19.82 9.27 12 530584 144 90097707
Pathological fracture 19.74 9.27 110 530486 9550 90088301
Bladder disorder 19.63 9.27 119 530477 10653 90087198
Essential tremor 19.58 9.27 32 530564 1380 90096471
Weight decreased 19.56 9.27 2525 528071 377385 89720466
Urinary tract infection pseudomonal 19.49 9.27 26 530570 932 90096919
Gastric ulcer 19.45 9.27 246 530350 27202 90070649
Bronchitis 19.42 9.27 1088 529508 151839 89946012
Blood cholesterol decreased 19.37 9.27 38 530558 1893 90095958
Depressed mood 19.37 9.27 407 530189 49815 90048036
Metastases to lymph nodes 19.29 9.27 24 530572 11665 90086186
Tooth disorder 19.29 9.27 272 530324 30818 90067033
Photopsia 19.25 9.27 69 530527 4955 90092896
Glomerular filtration rate decreased 19.24 9.27 167 530429 16765 90081086
Aplastic anaemia 19.14 9.27 30 530566 13239 90084612
Caesarean section 19.14 9.27 51 530545 18526 90079325
Withdrawal syndrome 19.12 9.27 209 530387 22315 90075536
Flushing 19.12 9.27 665 529931 87826 90010025
Drug abuse 19.09 9.27 353 530243 81994 90015857
Hepatitis acute 19.04 9.27 119 530477 10768 90087083
Acquired oesophageal web 19.03 9.27 14 530582 237 90097614
Hypocholesterolaemia 18.96 9.27 7 530589 6442 90091409
Escherichia urinary tract infection 18.81 9.27 142 530454 13673 90084178
Ascites 18.78 9.27 388 530208 47352 90050499
Compartment syndrome 18.74 9.27 48 530548 2864 90094987
Gallbladder cholesterolosis 18.56 9.27 23 530573 765 90097086
Vitamin D decreased 18.55 9.27 127 530469 11852 90085999
Unintentional medical device removal 18.48 9.27 9 530587 7021 90090830
Torsade de pointes 18.44 9.27 152 530444 15030 90082821
Vertigo positional 18.38 9.27 52 530544 3292 90094559
Congenital ovarian anomaly 18.36 9.27 6 530590 12 90097839
Sensory loss 18.36 9.27 174 530422 17901 90079950
Abnormal weight gain 18.27 9.27 45 530551 2620 90095231
Blood parathyroid hormone decreased 18.22 9.27 27 530569 12189 90085662
Post transplant lymphoproliferative disorder 18.11 9.27 9 530587 6940 90090911
Limb injury 18.10 9.27 272 530324 31236 90066615
Gastric haemorrhage 18.08 9.27 86 530510 7017 90090834
Urine output decreased 17.99 9.27 131 530465 12472 90085379
Ischaemic hepatitis 17.93 9.27 46 530550 2747 90095104
Blast cells present 17.89 9.27 19 530577 533 90097318
Pharyngeal oedema 17.89 9.27 140 530456 13631 90084220
COVID-19 17.84 9.27 1182 529414 167661 89930190
Gingival pain 17.82 9.27 107 530489 9545 90088306
Chronic kidney disease-mineral and bone disorder 17.82 9.27 11 530585 137 90097714
Pulseless electrical activity 17.78 9.27 101 530495 8831 90089020
Product dispensing error 17.76 9.27 128 530468 12145 90085706
Beta haemolytic streptococcal infection 17.76 9.27 43 530553 2476 90095375
Gallbladder adenocarcinoma 17.74 9.27 10 530586 104 90097747
Gastric antral vascular ectasia 17.64 9.27 23 530573 806 90097045
Hypovolaemia 17.62 9.27 129 530467 12302 90085549
Sleep disorder due to a general medical condition 17.60 9.27 172 530424 44566 90053285
Barrett's oesophagus 17.58 9.27 19 530577 544 90097307
Atrophic vulvovaginitis 17.58 9.27 36 530560 1851 90096000
Acute coronary syndrome 17.56 9.27 116 530480 10697 90087154
Product administration error 17.55 9.27 234 530362 26189 90071662
Fungal infection 17.53 9.27 349 530247 42312 90055539
Mental status changes 17.53 9.27 363 530233 44316 90053535
Renal function test abnormal 17.53 9.27 86 530510 7105 90090746
Body height decreased 17.51 9.27 125 530471 11824 90086027
Blood chromogranin A increased 17.51 9.27 16 530580 372 90097479
Avian influenza 17.45 9.27 9 530587 77 90097774
Hypertonia 17.42 9.27 68 530528 5087 90092764
Epigastric discomfort 17.39 9.27 89 530507 7479 90090372
Vascular encephalopathy 17.38 9.27 22 530574 748 90097103
Product residue present 17.36 9.27 60 530536 4231 90093620
Product taste abnormal 17.36 9.27 42 530554 2418 90095433
Thinking abnormal 17.35 9.27 123 530473 11609 90086242
Listless 17.35 9.27 50 530546 3199 90094652
Blood bilirubin increased 17.33 9.27 354 530242 43116 90054735
Arrhythmia 17.30 9.27 346 530250 41986 90055865
Atrial flutter 17.22 9.27 115 530481 10643 90087208
Genital ulceration 17.21 9.27 26 530570 1047 90096804
Multimorbidity 17.19 9.27 20 530576 622 90097229
Seasonal allergy 17.16 9.27 208 530388 22775 90075076
Gastrointestinal polyp 17.10 9.27 11 530585 148 90097703
Acute psychosis 17.05 9.27 48 530548 3030 90094821
Atrioventricular block second degree 16.93 9.27 61 530535 4391 90093460
Enthesopathy 16.93 9.27 18 530578 9386 90088465
Suicide attempt 16.93 9.27 325 530271 75074 90022777
Lichen planus 16.93 9.27 45 530551 2746 90095105
Thrombocytopenia 16.82 9.27 1430 529166 207295 89890556
Hepatitis toxic 16.77 9.27 54 530542 3671 90094180
Oesophageal stenosis 16.72 9.27 55 530541 3781 90094070
Xeroderma 16.69 9.27 15 530581 341 90097510
Blood phosphorus decreased 16.68 9.27 66 530530 4968 90092883
Osteopenia 16.66 9.27 207 530389 22795 90075056
Increased tendency to bruise 16.63 9.27 123 530473 11767 90086084
Sputum retention 16.60 9.27 20 530576 646 90097205
Atypical femur fracture 16.53 9.27 78 530518 6343 90091508
Psychomotor hyperactivity 16.50 9.27 130 530466 12683 90085168
Gamma-glutamyltransferase increased 16.45 9.27 313 530283 37639 90060212
Limb operation 16.35 9.27 61 530535 4466 90093385
Intentional overdose 16.34 9.27 421 530175 93413 90004438
Mesenteric artery thrombosis 16.23 9.27 13 530583 251 90097600
Product administration interrupted 16.23 9.27 127 530469 12365 90085486
Therapy interrupted 16.17 9.27 396 530200 49712 90048139
Oesophageal candidiasis 16.17 9.27 81 530515 6748 90091103
Wrist fracture 16.16 9.27 151 530445 15473 90082378
Gastrointestinal erosion 16.15 9.27 21 530575 734 90097117
Phlebitis 16.12 9.27 86 530510 7344 90090507
Limb hypoplasia congenital 15.93 9.27 12 530584 211 90097640
Gingival bleeding 15.91 9.27 145 530451 14758 90083093
Product odour abnormal 15.86 9.27 31 530565 1540 90096311
Eye swelling 15.85 9.27 251 530345 29135 90068716
Necrosis ischaemic 15.81 9.27 24 530572 971 90096880
Intravascular haemolysis 15.80 9.27 16 530580 424 90097427
Drug dose titration not performed 15.78 9.27 21 530575 751 90097100
Pregnancy with contraceptive device 15.76 9.27 5 530591 5061 90092790
Petechiae 15.72 9.27 151 530445 15590 90082261
Gastrointestinal stoma complication 15.70 9.27 40 530556 2379 90095472
Lung consolidation 15.67 9.27 63 530533 4777 90093074
Renal pain 15.62 9.27 88 530508 7671 90090180
Respirovirus test positive 15.56 9.27 6 530590 23 90097828
Extrasystoles 15.51 9.27 70 530526 5587 90092264
Rib fracture 15.50 9.27 229 530367 26206 90071645
Lung infiltration 15.46 9.27 147 530449 15135 90082716
Pleural effusion 15.46 9.27 803 529793 111188 89986663
Giardiasis 15.46 9.27 9 530587 100 90097751
Cytomegalovirus viraemia 15.44 9.27 13 530583 7573 90090278
Eye infection 15.37 9.27 139 530457 14115 90083736
Colitis microscopic 15.36 9.27 115 530481 11044 90086807
Dental discomfort 15.31 9.27 17 530579 502 90097349
Colitis 15.21 9.27 526 530070 69416 90028435
Thoracic vertebral fracture 15.20 9.27 68 530528 5406 90092445
Poor peripheral circulation 15.18 9.27 55 530541 3970 90093881
Discoloured vomit 15.18 9.27 26 530570 1166 90096685
Hand-eye coordination impaired 15.17 9.27 6 530590 25 90097826
Device use error 15.17 9.27 12 530584 7209 90090642
Stupor 15.15 9.27 68 530528 5414 90092437
Neuroglycopenia 15.10 9.27 25 530571 1090 90096761
Idiopathic pulmonary fibrosis 15.07 9.27 31 530565 1599 90096252
Sluggishness 15.06 9.27 72 530524 5887 90091964
Gastric disorder 15.05 9.27 277 530319 33107 90064744
Type I hypersensitivity 15.02 9.27 56 530540 4099 90093752
Vulvovaginal ulceration 14.99 9.27 6 530590 26 90097825
Leukocytosis 14.99 9.27 260 530336 30730 90067121
Myoclonus 14.98 9.27 175 530421 18993 90078858
Product prescribing error 14.97 9.27 254 530342 29891 90067960
Intervertebral disc protrusion 14.94 9.27 233 530363 26963 90070888
Toxic shock syndrome 14.94 9.27 24 530572 1020 90096831
Expired product administered 14.93 9.27 80 530516 6842 90091009
Pollakiuria 14.93 9.27 274 530322 32731 90065120
Face oedema 14.87 9.27 205 530391 23113 90074738
Dermatitis exfoliative 14.80 9.27 68 530528 5468 90092383
Neuralgia 14.77 9.27 263 530333 31237 90066614
Menstrual disorder 14.67 9.27 73 530523 6065 90091786
Ventricular fibrillation 14.66 9.27 136 530460 13908 90083943
Renal atrophy 14.62 9.27 33 530563 1815 90096036
Obstructive airways disorder 14.62 9.27 90 530506 25779 90072072
Anaemia folate deficiency 14.61 9.27 17 530579 529 90097322
Cleft palate 14.56 9.27 27 530569 1289 90096562
Otospondylomegaepiphyseal dysplasia 14.52 9.27 9 530587 113 90097738
Developmental hip dysplasia 14.48 9.27 30 530566 1555 90096296
Cerebrovascular arteriovenous malformation 14.46 9.27 8 530588 80 90097771
Intestinal ulcer 14.44 9.27 31 530565 1648 90096203
Hypersomnia 14.43 9.27 191 530405 21340 90076511
Blood electrolytes decreased 14.43 9.27 29 530567 1471 90096380
Nasal polyps 14.40 9.27 26 530570 10854 90086997
Choluria 14.34 9.27 12 530584 247 90097604
Reduced facial expression 14.32 9.27 40 530556 2513 90095338
Lung opacity 14.32 9.27 9 530587 6093 90091758
Gallbladder hypofunction 14.32 9.27 16 530580 476 90097375
Polyarthritis 14.31 9.27 57 530539 18293 90079558
Aquagenic pruritus 14.30 9.27 6 530590 30 90097821
Intraocular pressure test 14.30 9.27 7 530589 53 90097798
Nocturia 14.30 9.27 106 530490 10149 90087702
Septic shock 14.29 9.27 616 529980 83544 90014307
Creatinine renal clearance increased 14.26 9.27 47 530549 3234 90094617
Blood loss anaemia 14.24 9.27 105 530491 10035 90087816
Fear of eating 14.23 9.27 15 530581 417 90097434
Antithrombin III 14.23 9.27 10 530586 157 90097694
Apathy 14.21 9.27 112 530484 10928 90086923
Radius fracture 14.20 9.27 54 530542 3990 90093861
Helicobacter gastritis 14.17 9.27 31 530565 1669 90096182
Hypoxia 14.16 9.27 538 530058 71861 90025990
Bromhidrosis 14.14 9.27 5 530591 14 90097837
Endoscopy abnormal 14.14 9.27 5 530591 14 90097837
Failure to thrive 14.13 9.27 91 530505 8320 90089531
Tooth loss 14.11 9.27 84 530512 7470 90090381
Cataract nuclear 14.11 9.27 24 530572 1070 90096781
Cerebral haematoma 14.03 9.27 56 530540 4233 90093618
Stoma site infection 14.02 9.27 22 530574 916 90096935
Musculoskeletal chest pain 14.02 9.27 206 530390 23544 90074307
Oedematous pancreatitis 14.01 9.27 20 530576 765 90097086
Food aversion 14.00 9.27 27 530569 1328 90096523
Superior mesenteric artery syndrome 13.99 9.27 9 530587 121 90097730
Streptococcus test positive 13.97 9.27 28 530568 1417 90096434
Incoherent 13.95 9.27 62 530534 4915 90092936
Renal neoplasm 13.94 9.27 29 530567 1508 90096343
Foreign body 13.92 9.27 39 530557 2455 90095396
Erythrodermic psoriasis 13.92 9.27 24 530572 1082 90096769
Urine chloride decreased 13.89 9.27 8 530588 87 90097764
Poor sucking reflex 13.86 9.27 15 530581 430 90097421
Laryngeal oedema 13.82 9.27 78 530518 6803 90091048
Congenital oral malformation 13.79 9.27 11 530585 211 90097640
Colonic abscess 13.72 9.27 26 530570 1262 90096589
Ecchymosis 13.72 9.27 121 530475 12202 90085649
Cerebral haemorrhage 13.72 9.27 281 530315 34241 90063610
Coma 13.70 9.27 322 530274 72310 90025541
Renal haemangioma 13.70 9.27 6 530590 34 90097817
Salmonellosis 13.62 9.27 26 530570 1269 90096582
Gastrooesophageal reflux disease 13.62 9.27 1141 529455 165196 89932655
Pituitary tumour benign 13.57 9.27 35 530561 2097 90095754
Anticholinergic syndrome 13.49 9.27 41 530555 2702 90095149
Magnesium deficiency 13.48 9.27 19 530577 718 90097133
Derailment 13.47 9.27 7 530589 61 90097790
Crying 13.44 9.27 218 530378 25427 90072424
Infective exacerbation of chronic obstructive airways disease 13.43 9.27 28 530568 1458 90096393
Sepsis syndrome 13.42 9.27 22 530574 951 90096900
Prevertebral soft tissue swelling of cervical space 13.41 9.27 6 530590 36 90097815
Sinus node dysfunction 13.39 9.27 65 530531 5347 90092504
Arteriosclerosis 13.37 9.27 109 530487 10744 90087107
Mastication disorder 13.31 9.27 38 530558 2418 90095433
Spinal osteoarthritis 13.31 9.27 171 530425 18977 90078874
Vitamin B12 decreased 13.30 9.27 64 530532 5246 90092605
Potentiating drug interaction 13.30 9.27 67 530529 5595 90092256
Retching 13.28 9.27 171 530425 18988 90078863
Tangentiality 13.28 9.27 7 530589 63 90097788
Decreased interest 13.20 9.27 56 530540 4351 90093500
Bradyphrenia 13.18 9.27 83 530513 7529 90090322
Antineutrophil cytoplasmic antibody positive 13.17 9.27 19 530577 734 90097117
Nasal congestion 13.17 9.27 606 529990 82808 90015043
Musculoskeletal discomfort 13.16 9.27 184 530412 20807 90077044
Mitral valve incompetence 13.16 9.27 195 530401 22329 90075522
Cerebral disorder 13.11 9.27 67 530529 5627 90092224
Polymyositis 13.08 9.27 35 530561 2144 90095707
Upper limb fracture 13.07 9.27 188 530408 21390 90076461
Bipolar I disorder 13.07 9.27 34 530562 2048 90095803
Pathogen resistance 13.04 9.27 17 530579 8098 90089753
Influenza like illness 13.02 9.27 587 530009 80024 90017827
Oesophageal adenocarcinoma 12.98 9.27 10 530586 182 90097669
Fracture nonunion 12.95 9.27 36 530560 2256 90095595
Paralysis 12.93 9.27 113 530483 11365 90086486
Norovirus test positive 12.92 9.27 11 530585 232 90097619
Cholangitis 12.87 9.27 79 530517 7103 90090748
Osteoporosis 12.86 9.27 449 530147 96082 90001769
Foreign body in reproductive tract 12.84 9.27 24 530572 1153 90096698
Pelvic pain 12.81 9.27 142 530454 15215 90082636
Hepatitis cholestatic 12.81 9.27 90 530506 8471 90089380
Mental impairment 12.78 9.27 152 530444 16568 90081283
Asthma 12.77 9.27 1232 529364 240928 89856923
Platelet count increased 12.74 9.27 182 530414 20677 90077174
Dental caries 12.73 9.27 112 530484 11285 90086566
Catarrh 12.73 9.27 29 530567 1605 90096246
Dyspepsia 12.69 9.27 993 529603 197167 89900684
Anal haemorrhage 12.67 9.27 38 530558 2486 90095365
Cardiac steatosis 12.65 9.27 6 530590 42 90097809
Ligament sprain 12.64 9.27 136 530460 14463 90083388
Erosive oesophagitis 12.64 9.27 31 530565 1800 90096051
Subdural haematoma 12.58 9.27 151 530445 16494 90081357
Sweat discolouration 12.58 9.27 4 530592 7 90097844
Tympanic membrane hyperaemia 12.58 9.27 4 530592 7 90097844
Tongue discolouration 12.56 9.27 47 530549 3446 90094405
DNA antibody 12.53 9.27 6 530590 43 90097808
Hair injury 12.53 9.27 6 530590 43 90097808
Haemorrhage 12.52 9.27 511 530085 68858 90028993
Carotid artery disease 12.46 9.27 29 530567 1628 90096223
High density lipoprotein decreased 12.46 9.27 39 530557 2612 90095239
Blood pressure decreased 12.45 9.27 547 530049 74348 90023503
Presumed ocular histoplasmosis syndrome 12.44 9.27 3 530593 0 90097851
Feeding disorder 12.43 9.27 157 530439 17355 90080496
Swelling of eyelid 12.43 9.27 64 530532 5390 90092461
Feeling cold 12.42 9.27 228 530368 27237 90070614
Hepatomegaly 12.42 9.27 126 530470 13200 90084651
Calcium metabolism disorder 12.40 9.27 9 530587 149 90097702
Bedridden 12.36 9.27 117 530479 12031 90085820
Urine output increased 12.34 9.27 30 530566 1732 90096119
Hyponatraemic syndrome 12.33 9.27 16 530580 558 90097293
Dermatitis psoriasiform 12.27 9.27 39 530557 2633 90095218
Visual acuity reduced 12.27 9.27 199 530397 23211 90074640
Blood potassium increased 12.26 9.27 180 530416 20569 90077282
Miosis 12.26 9.27 23 530573 9461 90088390
Osteochondritis 12.25 9.27 5 530591 23 90097828
Lymphadenopathy 12.25 9.27 353 530243 45422 90052429
Facial paralysis 12.22 9.27 142 530454 15392 90082459
Diabetes mellitus inadequate control 12.21 9.27 165 530431 18519 90079332
Vascular dementia 12.20 9.27 16 530580 564 90097287
Magnesium metabolism disorder 12.19 9.27 6 530590 46 90097805
Mucosal inflammation 12.19 9.27 432 530164 57193 90040658
Formication 12.19 9.27 58 530538 4733 90093118
Sensory disturbance 12.17 9.27 141 530455 15272 90082579
Sinonasal obstruction 12.17 9.27 11 530585 252 90097599
Tendon sheath incision 12.16 9.27 7 530589 76 90097775
Intramedullary rod insertion 12.16 9.27 34 530562 2138 90095713
Dry throat 12.09 9.27 84 530512 7876 90089975
Protein total decreased 12.09 9.27 77 530519 7012 90090839
Burns second degree 12.09 9.27 32 530564 1948 90095903
Vasculitic rash 12.08 9.27 26 530570 1384 90096467
Hyperventilation 12.05 9.27 74 530522 6654 90091197
Osteomalacia 12.03 9.27 20 530576 875 90096976
Lung adenocarcinoma stage IV 12.02 9.27 14 530582 436 90097415
Red blood cell count decreased 12.01 9.27 356 530240 45995 90051856
Parkinsonian rest tremor 12.00 9.27 9 530587 157 90097694
Joint abscess 11.92 9.27 14 530582 440 90097411
Lactation disorder 11.92 9.27 14 530582 440 90097411
Faecaloma 11.91 9.27 103 530493 10328 90087523
Intervertebral disc degeneration 11.90 9.27 154 530442 17120 90080731
Internal fixation of fracture 11.87 9.27 19 530577 805 90097046
Urine sodium decreased 11.81 9.27 9 530587 161 90097690
Skin texture abnormal 11.79 9.27 16 530580 583 90097268
Stress ulcer 11.77 9.27 6 530590 50 90097801
Overdose 11.77 9.27 780 529816 156929 89940922
Exposure via breast milk 11.76 9.27 35 530561 2280 90095571
Radiculopathy 11.74 9.27 62 530534 18443 90079408
Faecal volume decreased 11.71 9.27 11 530585 265 90097586
Aspiration 11.70 9.27 142 530454 15551 90082300
Appendicitis 11.67 9.27 101 530495 10130 90087721
Dolichocolon 11.67 9.27 6 530590 51 90097800
Gastrointestinal obstruction 11.67 9.27 25 530571 1327 90096524
Ventricular dysfunction 11.63 9.27 48 530548 3683 90094168
Hepatic steatosis 11.63 9.27 291 530305 36654 90061197
Intraductal papillary breast neoplasm 11.63 9.27 4 530592 10 90097841
Hernia 11.60 9.27 131 530465 14100 90083751
Cardio-respiratory arrest 11.60 9.27 466 530130 62674 90035177
Acute graft versus host disease 11.59 9.27 9 530587 5459 90092392
Starvation ketoacidosis 11.59 9.27 10 530586 215 90097636
Sudden cardiac death 11.58 9.27 34 530562 2198 90095653
Poliomyelitis 11.57 9.27 6 530590 52 90097799
Thrombosis mesenteric vessel 11.56 9.27 7 530589 84 90097767
Aortic stenosis 11.55 9.27 70 530526 6266 90091585
Stillbirth 11.55 9.27 16 530580 7427 90090424
Facial bones fracture 11.52 9.27 48 530548 3699 90094152
Oesophageal irritation 11.52 9.27 12 530584 329 90097522
Right ventricular failure 11.51 9.27 167 530429 19038 90078813
Dissociation 11.49 9.27 73 530523 6642 90091209
Blood pressure diastolic decreased 11.47 9.27 101 530495 26725 90071126
Salivary gland enlargement 11.47 9.27 13 530583 393 90097458
BK virus infection 11.46 9.27 6 530590 4492 90093359
Cardiac disorder 11.45 9.27 424 530172 56448 90041403
Nasal ulcer 11.42 9.27 38 530558 2628 90095223
Nasal oedema 11.42 9.27 13 530583 6571 90091280
Low turnover osteopathy 11.42 9.27 52 530544 4166 90093685
Peripheral coldness 11.38 9.27 128 530468 13764 90084087
Blindness unilateral 11.38 9.27 81 530515 7655 90090196
Acquired cystic kidney disease 11.38 9.27 6 530590 54 90097797
Deformity 11.37 9.27 35 530561 12135 90085716
Haemorrhagic stroke 11.36 9.27 71 530525 6425 90091426
Chronic graft versus host disease 11.34 9.27 5 530591 4134 90093717
Reaction to excipient 11.29 9.27 30 530566 1830 90096021
Thrombophlebitis 11.25 9.27 57 530539 4771 90093080
Blood phosphorus abnormal 11.23 9.27 9 530587 174 90097677
Bone disorder 11.19 9.27 194 530402 22926 90074925
Vulvar basal cell carcinoma 11.18 9.27 5 530591 30 90097821
Spinal compression fracture 11.17 9.27 137 530459 15041 90082810
Allergy to chemicals 11.16 9.27 4 530592 3750 90094101
Tanning 11.15 9.27 7 530589 90 90097761
Cystic fibrosis lung 11.15 9.27 8 530588 130 90097721
Eosinophilic cellulitis 11.14 9.27 10 530586 227 90097624
Hypomania 11.13 9.27 22 530574 8875 90088976
Liver palpable 11.11 9.27 4 530592 12 90097839
Urticaria vesiculosa 11.11 9.27 4 530592 12 90097839
Nikolsky's sign 11.08 9.27 7 530589 91 90097760
Sudden death 11.07 9.27 105 530491 10804 90087047
Paranoia 11.06 9.27 120 530476 12788 90085063
Gastrointestinal mucosal exfoliation 11.05 9.27 8 530588 132 90097719
Microcytic anaemia 11.04 9.27 48 530548 3770 90094081
Erythema multiforme 11.04 9.27 115 530481 12131 90085720
Myxofibrosarcoma 11.02 9.27 7 530589 92 90097759
Abdominal pain upper 11.01 9.27 2158 528438 330516 89767335
Drug use disorder 10.99 9.27 20 530576 8323 90089528
Microalbuminuria 10.98 9.27 15 530581 550 90097301
Urosepsis 10.95 9.27 180 530416 21052 90076799
White blood cell count increased 10.94 9.27 490 530106 66751 90031100
Blood triglycerides increased 10.92 9.27 126 530470 13635 90084216
Volvulus 10.90 9.27 33 530563 2170 90095681
Acinetobacter test positive 10.89 9.27 7 530589 94 90097757
Osmotic demyelination syndrome 10.89 9.27 21 530575 1033 90096818
Splenic calcification 10.87 9.27 4 530592 13 90097838
Hepatitis 10.87 9.27 323 530273 70416 90027435
Economic problem 10.86 9.27 43 530553 3238 90094613
Pancreatitis chronic 10.85 9.27 39 530557 2804 90095047
Humerus fracture 10.85 9.27 96 530500 9689 90088162
Renal cell carcinoma 10.82 9.27 48 530548 3803 90094048
Hypertensive cardiomyopathy 10.82 9.27 11 530585 293 90097558
Anaemia postoperative 10.81 9.27 33 530563 2180 90095671
Renal artery arteriosclerosis 10.78 9.27 5 530591 33 90097818
Intracranial haemangioma 10.78 9.27 5 530591 33 90097818
Coagulopathy 10.77 9.27 194 530402 23095 90074756
Angina pectoris 10.76 9.27 303 530293 38857 90058994
Differential white blood cell count abnormal 10.74 9.27 20 530576 958 90096893
Social avoidant behaviour 10.71 9.27 44 530552 3369 90094482
Scleroderma 10.68 9.27 68 530528 6193 90091658
Hospice care 10.66 9.27 95 530501 9609 90088242
Ear, nose and throat examination abnormal 10.65 9.27 4 530592 14 90097837
Achlorhydria 10.65 9.27 4 530592 14 90097837
Confusion postoperative 10.65 9.27 10 530586 241 90097610
Zinc deficiency 10.64 9.27 7 530589 98 90097753
Mental status changes postoperative 10.61 9.27 9 530587 189 90097662
Neutropenia 10.59 9.27 1487 529109 223417 89874434
Oedema peripheral 10.58 9.27 1692 528904 256223 89841628
Hypoglycaemic coma 10.56 9.27 40 530556 2950 90094901
Adrenal neoplasm 10.55 9.27 13 530583 430 90097421
Oroantral fistula 10.53 9.27 9 530587 191 90097660
Sarcoma 10.53 9.27 16 530580 648 90097203
Dermatitis diaper 10.49 9.27 11 530585 304 90097547
Tympanic membrane disorder 10.45 9.27 9 530587 193 90097658
Urethritis 10.41 9.27 10 530586 248 90097603
Electrolyte depletion 10.41 9.27 9 530587 194 90097657
Localised oedema 10.39 9.27 67 530529 6127 90091724
Mean cell volume abnormal 10.39 9.27 13 530583 437 90097414
Diabetic gastropathy 10.38 9.27 3 530593 3 90097848
Campylobacter sepsis 10.38 9.27 3 530593 3 90097848
Occupational problem environmental 10.38 9.27 3 530593 3 90097848
Apraxia 10.37 9.27 33 530563 2229 90095622
Polyserositis 10.36 9.27 16 530580 657 90097194
Left ventricular failure 10.35 9.27 71 530525 6629 90091222
Cardiomegaly 10.34 9.27 162 530434 18763 90079088
Azotaemia 10.34 9.27 60 530536 5288 90092563
Dermatitis bullous 10.32 9.27 99 530497 10217 90087634
Kidney infection 10.31 9.27 211 530385 25705 90072146
Vanishing bile duct syndrome 10.30 9.27 24 530572 1348 90096503
Blood test abnormal 10.29 9.27 76 530520 20876 90076975
Hypovolaemic shock 10.28 9.27 74 530522 7020 90090831
Feeling drunk 10.27 9.27 55 530541 4703 90093148
Ankle fracture 10.25 9.27 172 530424 20198 90077653
X-ray of pelvis and hip abnormal 10.24 9.27 4 530592 16 90097835
Granulocytopenia neonatal 10.24 9.27 4 530592 16 90097835
Urinary tract disorder 10.23 9.27 46 530550 3665 90094186
Cytopenia 10.23 9.27 60 530536 17389 90080462
Haematocrit decreased 10.23 9.27 319 530277 41513 90056338
Abscess neck 10.22 9.27 17 530579 744 90097107
Renal tuberculosis 10.20 9.27 5 530591 38 90097813
Central nervous system haemorrhage 10.19 9.27 10 530586 255 90097596
Genital neoplasm malignant female 10.18 9.27 8 530588 150 90097701
Cholestasis of pregnancy 10.15 9.27 26 530570 1551 90096300
Pyogenic granuloma 10.15 9.27 11 530585 316 90097535
Anhedonia 10.14 9.27 107 530489 11324 90086527
Heart rate irregular 10.13 9.27 199 530397 24069 90073782
Gastrointestinal stoma output increased 10.12 9.27 15 530581 594 90097257
Diffuse large B-cell lymphoma recurrent 10.08 9.27 4 530592 3522 90094329
Blood phosphorus increased 10.07 9.27 51 530545 4267 90093584
Respiratory distress 10.06 9.27 299 530297 38647 90059204
Coronary artery occlusion 10.05 9.27 85 530511 8469 90089382
Atrioventricular block 10.04 9.27 87 530509 8728 90089123
Systemic inflammatory response syndrome 10.04 9.27 69 530527 6447 90091404
Body temperature decreased 10.04 9.27 90 530506 23726 90074125
Cholesterosis 10.03 9.27 13 530583 453 90097398
Blood albumin decreased 10.02 9.27 146 530450 16657 90081194
Cholangiocarcinoma 10.01 9.27 23 530573 1280 90096571
Antidepressant drug level increased 10.00 9.27 12 530584 386 90097465
Hepatic haematoma 9.99 9.27 14 530582 526 90097325
Prothrombin level decreased 9.99 9.27 16 530580 678 90097173
Drop attacks 9.99 9.27 16 530580 678 90097173
Eyelid disorder 9.98 9.27 32 530564 2171 90095680
Ear haemorrhage 9.95 9.27 26 530570 1570 90096281
Urinary tract infection bacterial 9.95 9.27 67 530529 6218 90091633
Bile duct stone 9.93 9.27 49 530547 4058 90093793
Viral labyrinthitis 9.92 9.27 3 530593 4 90097847
Gastritis bacterial 9.92 9.27 8 530588 156 90097695
Subileus 9.92 9.27 45 530551 3599 90094252
Bladder irritation 9.88 9.27 11 530585 326 90097525
Pulmonary artery atresia 9.87 9.27 4 530592 18 90097833
Gout 9.86 9.27 146 530450 16713 90081138
Kidney small 9.86 9.27 9 530587 209 90097642
Infective exacerbation of bronchiectasis 9.85 9.27 13 530583 461 90097390
Product physical consistency issue 9.85 9.27 19 530577 935 90096916
Ovarian germ cell cancer stage II 9.84 9.27 6 530590 73 90097778
Oropharyngeal blistering 9.84 9.27 20 530576 1023 90096828
Diabetic ketoacidosis 9.81 9.27 199 530397 24208 90073643
Blood chloride decreased 9.79 9.27 67 530529 6252 90091599
Metabolic acidosis 9.79 9.27 409 530187 55267 90042584
Eyelid erosion 9.77 9.27 5 530591 42 90097809
Skin tightness 9.77 9.27 52 530544 4436 90093415
Hypotensive crisis 9.77 9.27 6 530590 74 90097777
Abdominal adhesions 9.75 9.27 44 530552 3511 90094340
Oral disorder 9.73 9.27 98 530498 10247 90087604
Splenic infarction 9.73 9.27 31 530565 2096 90095755
Acute sinusitis 9.71 9.27 50 530546 4211 90093640
Primary myelofibrosis 9.70 9.27 6 530590 75 90097776
Urethritis noninfective 9.70 9.27 4 530592 19 90097832
Cartilage injury 9.69 9.27 31 530565 2100 90095751
Albumin globulin ratio increased 9.68 9.27 5 530591 43 90097808
Culture positive 9.66 9.27 13 530583 470 90097381
Transplant dysfunction 9.64 9.27 10 530586 5272 90092579
Shunt thrombosis 9.63 9.27 6 530590 76 90097775
Generalised oedema 9.63 9.27 161 530435 18892 90078959
Oesophageal ulcer 9.61 9.27 57 530539 5062 90092789
Graft versus host disease in gastrointestinal tract 9.59 9.27 7 530589 4381 90093470
Conversion disorder 9.56 9.27 31 530565 2115 90095736
Type V hyperlipidaemia 9.55 9.27 18 530578 870 90096981
Cardiac pacemaker insertion 9.55 9.27 51 530545 4356 90093495
Respiratory tract procedural complication 9.54 9.27 4 530592 20 90097831
Pyonephrosis 9.54 9.27 4 530592 20 90097831
Dysarthria 9.52 9.27 400 530196 54082 90043769
Portal vein thrombosis 9.50 9.27 40 530556 3098 90094753
Rash pustular 9.47 9.27 80 530516 7969 90089882
Tracheo-oesophageal fistula 9.46 9.27 16 530580 710 90097141
Dental restoration failure 9.45 9.27 21 530575 1143 90096708
Eye oedema 9.43 9.27 29 530567 1923 90095928
Blood pressure fluctuation 9.43 9.27 234 530362 52179 90045672
Calciphylaxis 9.42 9.27 42 530554 3334 90094517
Dyspnoea at rest 9.42 9.27 54 530542 4737 90093114
Spondylolisthesis 9.42 9.27 48 530548 4027 90093824
Skin atrophy 9.40 9.27 60 530536 5469 90092382
Accidental exposure to product 9.39 9.27 183 530413 42183 90055668
Regurgitation 9.39 9.27 31 530565 2135 90095716
Hypoglycaemic unconsciousness 9.39 9.27 17 530579 797 90097054
Fat intolerance 9.38 9.27 4 530592 21 90097830
Hepatic rupture 9.37 9.27 6 530590 80 90097771
Food interaction 9.37 9.27 22 530574 1242 90096609
Acetabulum fracture 9.37 9.27 12 530584 413 90097438
Breast enlargement 9.36 9.27 27 530569 1728 90096123
Non-small cell lung cancer metastatic 9.33 9.27 17 530579 801 90097050
Throat irritation 9.32 9.27 361 530235 48334 90049517
Acute interstitial pneumonitis 9.31 9.27 17 530579 802 90097049
Localised infection 9.31 9.27 260 530336 33302 90064549
Stress fracture 9.30 9.27 84 530512 8527 90089324
Lipidosis 9.30 9.27 5 530591 47 90097804
Mucosal dryness 9.30 9.27 40 530556 3127 90094724
Tarsal tunnel syndrome 9.28 9.27 14 530582 563 90097288
Fistula 9.28 9.27 110 530486 11979 90085872

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypomagnesaemia 870.62 11.04 1116 345782 27372 42247065
Off label use 668.60 11.04 2807 344091 635528 41638909
Drug ineffective 512.82 11.04 3026 343872 627171 41647266
Hypocalcaemia 379.05 11.04 790 346108 29383 42245054
Drug abuse 378.10 11.04 190 346708 104581 42169856
Chronic kidney disease 286.15 11.04 941 345957 46300 42228137
Tubulointerstitial nephritis 242.22 11.04 683 346215 30865 42243572
Toxicity to various agents 221.51 11.04 1035 345863 228101 42046336
Product use in unapproved indication 178.27 11.04 833 346065 183623 42090814
Treatment failure 172.77 11.04 153 346745 62471 42211966
Therapeutic product effect incomplete 138.64 11.04 227 346671 70712 42203725
Hypertrichosis 132.27 11.04 74 346824 524 42273913
Drug ineffective for unapproved indication 118.86 11.04 120 346778 46043 42228394
Drug resistance 109.35 11.04 72 346826 34176 42240261
Drug intolerance 107.16 11.04 318 346580 80106 42194331
Drug interaction 104.08 11.04 2877 344021 264122 42010315
Myelosuppression 102.10 11.04 107 346791 40354 42234083
Febrile neutropenia 95.48 11.04 1008 345890 184695 42089742
Hypoparathyroidism 94.47 11.04 64 346834 661 42273776
Abdominal pain upper 91.05 11.04 1051 345847 81558 42192879
General physical health deterioration 87.36 11.04 798 346100 150448 42123989
Tetany 85.25 11.04 72 346826 1060 42273377
Diarrhoea 82.95 11.04 4562 342336 456287 41818150
Lip swelling 82.83 11.04 341 346557 18712 42255725
Therapy partial responder 80.53 11.04 31 346867 19990 42254447
Condition aggravated 80.42 11.04 1567 345331 259187 42015250
Product formulation issue 79.70 11.04 60 346838 741 42273696
Completed suicide 77.76 11.04 463 346435 96002 42178435
Myalgia 73.02 11.04 1143 345755 94937 42179500
Acute kidney injury 72.98 11.04 3671 343227 363666 41910771
Death 70.53 11.04 3127 343771 468058 41806379
Multiple organ dysfunction syndrome 69.90 11.04 482 346416 96553 42177884
Drug use disorder 67.93 11.04 4 346894 10329 42264108
Obstructive airways disorder 67.65 11.04 61 346837 24698 42249739
Foetal exposure during pregnancy 67.49 11.04 181 346717 47130 42227307
Gastrooesophageal reflux disease 67.39 11.04 610 346288 44413 42230024
Chest pain 66.78 11.04 1546 345352 137984 42136453
Cardiospasm 66.71 11.04 80 346818 1827 42272610
Synovitis 66.20 11.04 22 346876 15545 42258892
Respiratory symptom 65.50 11.04 7 346891 11099 42263338
Cardiogenic shock 65.09 11.04 119 346779 35521 42238916
Palmoplantar keratoderma 63.68 11.04 85 346813 2169 42272268
Renal injury 62.50 11.04 231 346667 12049 42262388
Confusional state 60.48 11.04 1789 345109 165808 42108629
Dizziness 60.45 11.04 2542 344356 246712 42027725
C-reactive protein abnormal 59.64 11.04 4 346894 9257 42265180
Drug hypersensitivity 59.27 11.04 520 346378 98869 42175568
Asthenia 57.72 11.04 2816 344082 277977 41996460
Suicide attempt 57.35 11.04 188 346710 45912 42228525
Inappropriate antidiuretic hormone secretion 56.79 11.04 276 346622 16265 42258172
Incorrect route of product administration 56.17 11.04 69 346829 24236 42250201
Lower respiratory tract infection 54.57 11.04 544 346354 40662 42233775
Fatigue 54.21 11.04 4180 342718 431461 41842976
Poisoning 53.96 11.04 26 346872 14673 42259764
Coma 53.92 11.04 238 346660 53316 42221121
Gastric polyps 53.64 11.04 68 346830 1647 42272790
Drug dependence 51.49 11.04 99 346799 28995 42245442
Cytomegalovirus infection reactivation 50.79 11.04 14 346884 11164 42263273
Hiatus hernia 50.44 11.04 169 346729 8391 42266046
Gastritis 50.42 11.04 351 346547 23596 42250841
Infective pulmonary exacerbation of cystic fibrosis 50.26 11.04 159 346739 7659 42266778
Myasthenia gravis 50.07 11.04 35 346863 16102 42258335
Subacute cutaneous lupus erythematosus 49.74 11.04 61 346837 1427 42273010
Tinnitus 49.56 11.04 404 346494 28534 42245903
Pruritus genital 49.34 11.04 82 346816 2557 42271880
Disease progression 49.31 11.04 847 346051 142809 42131628
Hyperphosphataemia 49.29 11.04 22 346876 12982 42261455
Hyponatraemia 48.76 11.04 1125 345773 100337 42174100
Chromaturia 48.73 11.04 258 346640 15731 42258706
Haemophagocytic lymphohistiocytosis 48.48 11.04 46 346852 18176 42256261
Renal tubular acidosis 48.17 11.04 83 346815 2667 42271770
Palpitations 47.19 11.04 626 346272 50171 42224266
Overdose 47.14 11.04 589 346309 104675 42169762
Intercepted product preparation error 45.30 11.04 4 346894 7385 42267052
Eosinophilic oesophagitis 45.02 11.04 41 346857 671 42273766
Multiple-drug resistance 44.79 11.04 4 346894 7318 42267119
Tension headache 44.75 11.04 91 346807 3323 42271114
Plasma cell myeloma 44.48 11.04 587 346311 46991 42227446
Intentional overdose 44.12 11.04 242 346656 51214 42223223
Appendicitis 44.07 11.04 62 346836 20551 42253886
Blood pressure fluctuation 43.85 11.04 96 346802 26812 42247625
Immune reconstitution inflammatory syndrome 43.72 11.04 14 346884 10129 42264308
Hypokalaemia 43.52 11.04 823 346075 70898 42203539
Rectal haemorrhage 43.09 11.04 604 346294 49002 42225435
Facial pain 42.74 11.04 102 346796 4158 42270279
Atrial tachycardia 42.48 11.04 100 346798 4040 42270397
Dyspnoea 42.10 11.04 4164 342734 438457 41835980
Blood pressure systolic increased 41.41 11.04 105 346793 27863 42246574
Immunisation 41.13 11.04 51 346847 1207 42273230
Eosinophilic granulomatosis with polyangiitis 40.81 11.04 10 346888 8628 42265809
Dyspepsia 40.25 11.04 514 346384 40838 42233599
Sleep terror 39.55 11.04 79 346819 2847 42271590
Hypoparathyroidism secondary 39.12 11.04 23 346875 181 42274256
Dysgeusia 39.00 11.04 438 346460 33751 42240686
Anosmia 38.67 11.04 111 346787 5065 42269372
Malignant neoplasm progression 38.53 11.04 635 346263 107765 42166672
Migraine 38.37 11.04 345 346553 25069 42249368
Abdominal discomfort 38.21 11.04 841 346057 74414 42200023
Hypertensive nephropathy 38.12 11.04 32 346866 467 42273970
Abdominal pain 37.57 11.04 1903 344995 188568 42085869
Therapy non-responder 37.45 11.04 267 346631 53092 42221345
Product use issue 37.22 11.04 422 346476 76329 42198108
Muscle spasms 37.09 11.04 940 345958 85104 42189333
Neuritis 36.48 11.04 4 346894 6216 42268221
Mucormycosis 36.32 11.04 7 346891 7136 42267301
Hyperchlorhydria 36.06 11.04 35 346863 623 42273814
Substance abuse 35.46 11.04 14 346884 8891 42265546
Pathogen resistance 35.30 11.04 25 346873 11425 42263012
Nephrogenic anaemia 35.17 11.04 70 346828 2516 42271921
Pneumocystis jirovecii pneumonia 34.66 11.04 98 346800 25083 42249354
Occupational dermatitis 34.54 11.04 17 346881 89 42274348
Aplastic anaemia 34.45 11.04 30 346868 12354 42262083
Carotid artery occlusion 34.35 11.04 93 346805 4101 42270336
Full blood count abnormal 34.34 11.04 126 346772 29750 42244687
Insulin autoimmune syndrome 34.30 11.04 31 346867 502 42273935
Premature baby 34.22 11.04 87 346811 23066 42251371
Impaired quality of life 34.21 11.04 215 346683 13962 42260475
End stage renal disease 33.87 11.04 241 346657 16317 42258120
Blood pressure diastolic abnormal 33.38 11.04 5 346893 6123 42268314
Interstitial lung disease 32.92 11.04 445 346453 78017 42196420
Blood phosphorus increased 32.87 11.04 32 346866 12493 42261944
Blood magnesium decreased 32.57 11.04 137 346761 7589 42266848
Liver function test abnormal 32.54 11.04 405 346493 31986 42242451
Swollen tongue 32.45 11.04 289 346609 20942 42253495
Muscular weakness 32.19 11.04 899 345999 82599 42191838
International normalised ratio increased 32.12 11.04 561 346337 47607 42226830
Angioedema 32.11 11.04 505 346393 41972 42232465
Infusion related reaction 32.02 11.04 328 346570 60478 42213959
Hallucination 31.88 11.04 651 346247 56856 42217581
Muscle twitching 31.83 11.04 184 346714 11596 42262841
Heart rate decreased 31.76 11.04 171 346727 36361 42238076
BK virus infection 31.55 11.04 16 346882 8768 42265669
Venoocclusive liver disease 31.10 11.04 23 346875 10279 42264158
Oesophagitis 30.65 11.04 221 346677 15026 42259411
Intentional product misuse 30.54 11.04 339 346559 61561 42212876
Gastric mucosal hypertrophy 30.03 11.04 19 346879 173 42274264
Iron deficiency anaemia 29.77 11.04 195 346703 12844 42261593
Cytomegalovirus infection 29.33 11.04 149 346749 32157 42242280
Vomiting 29.29 11.04 2738 344160 286985 41987452
Mycotic allergy 29.05 11.04 3 346895 4888 42269549
Dehydration 28.89 11.04 1421 345477 140346 42134091
Lethargy 28.76 11.04 539 346359 46351 42228086
Rash papular 28.42 11.04 179 346719 11632 42262805
Cystitis haemorrhagic 28.41 11.04 12 346886 7317 42267120
Headache 28.21 11.04 2288 344610 237081 42037356
Jejunal ulcer perforation 28.19 11.04 14 346884 75 42274362
Brain scan abnormal 28.01 11.04 42 346856 1197 42273240
Conjunctivitis allergic 27.62 11.04 7 346891 5904 42268533
Multimorbidity 27.50 11.04 36 346862 901 42273536
Intentional product use issue 27.12 11.04 416 346482 71417 42203020
Renal failure 27.10 11.04 1430 345468 142296 42132141
Respiratory depression 27.04 11.04 72 346826 18796 42255641
Respiratory tract infection 26.82 11.04 330 346568 25992 42248445
Systemic infection 26.68 11.04 5 346893 5200 42269237
Diffuse large B-cell lymphoma recurrent 26.58 11.04 4 346894 4882 42269555
Graft versus host disease in gastrointestinal tract 26.24 11.04 5 346893 5138 42269299
Rheumatoid arthritis 26.19 11.04 220 346678 42220 42232217
Upper gastrointestinal haemorrhage 25.94 11.04 368 346530 29931 42244506
Weight increased 25.78 11.04 675 346223 107308 42167129
Inappropriate schedule of product administration 25.76 11.04 589 346309 95313 42179124
Pain of skin 25.74 11.04 132 346766 7948 42266489
Total lung capacity abnormal 25.70 11.04 3 346895 4440 42269997
Syncope 25.67 11.04 1021 345877 98385 42176052
Tetanus 25.64 11.04 12 346886 55 42274382
Oesophageal perforation 25.35 11.04 40 346858 1193 42273244
Right hemisphere deficit syndrome 25.31 11.04 9 346889 16 42274421
Hepatic encephalopathy 25.22 11.04 224 346674 16218 42258219
Antineutrophil cytoplasmic antibody positive 25.11 11.04 3 346895 4362 42270075
Blood pressure systolic abnormal 24.97 11.04 7 346891 5521 42268916
Pulmonary alveolar haemorrhage 24.86 11.04 52 346846 14764 42259673
Labelled drug-drug interaction medication error 24.80 11.04 214 346684 15368 42259069
Chronic graft versus host disease 24.78 11.04 9 346889 6016 42268421
Stress 24.74 11.04 235 346663 43977 42230460
Odynophagia 24.72 11.04 115 346783 6655 42267782
Loss of personal independence in daily activities 24.50 11.04 273 346625 49543 42224894
Device dependence 24.48 11.04 11 346887 45 42274392
Post transplant lymphoproliferative disorder 24.28 11.04 23 346875 9097 42265340
Sedation 24.15 11.04 147 346751 30328 42244109
Neutropenia 24.14 11.04 1352 345546 198079 42076358
Back pain 24.06 11.04 1397 345501 140379 42134058
Pancreatitis 24.04 11.04 490 346408 42778 42231659
Hepatic function abnormal 24.03 11.04 286 346612 51281 42223156
Bacterial infection 23.96 11.04 131 346767 27748 42246689
Soft tissue mass 23.87 11.04 35 346863 977 42273460
Meconium abnormal 23.76 11.04 12 346886 67 42274370
Gastrointestinal haemorrhage 23.69 11.04 997 345901 96729 42177708
Blood uric acid increased 23.30 11.04 58 346840 15489 42258948
Helicobacter test positive 23.17 11.04 31 346867 793 42273644
Blood chromogranin A increased 22.95 11.04 20 346878 308 42274129
Device leakage 22.93 11.04 30 346868 10255 42264182
Granuloma annulare 22.86 11.04 16 346882 175 42274262
Lymphopenia 22.82 11.04 94 346804 21469 42252968
Graft versus host disease in skin 22.81 11.04 7 346891 5205 42269232
Altered state of consciousness 22.74 11.04 142 346756 29117 42245320
Lung disorder 22.64 11.04 265 346633 47658 42226779
Blood pressure diastolic increased 22.51 11.04 12 346886 6393 42268044
Neurological symptom 22.42 11.04 29 346869 9962 42264475
Cytomegalovirus viraemia 22.39 11.04 31 346867 10346 42264091
Bronchopulmonary aspergillosis allergic 22.36 11.04 5 346893 4593 42269844
Pancreatic abscess 22.34 11.04 16 346882 182 42274255
Bronchopulmonary aspergillosis 22.29 11.04 82 346816 19347 42255090
Polyomavirus-associated nephropathy 22.08 11.04 9 346889 5606 42268831
Barrett's oesophagus 21.63 11.04 21 346877 374 42274063
Malaise 21.57 11.04 2006 344892 210150 42064287
Pneumatosis intestinalis 21.50 11.04 6 346892 4746 42269691
Dysphagia 21.44 11.04 758 346140 71961 42202476
Crohn's disease 21.34 11.04 63 346835 2921 42271516
Red blood cell sedimentation rate abnormal 21.20 11.04 3 346895 3833 42270604
Status epilepticus 21.17 11.04 61 346837 15517 42258920
Tenosynovitis 21.11 11.04 6 346892 4689 42269748
Lymphoma 21.02 11.04 54 346844 14267 42260170
Hepatic cytolysis 21.00 11.04 130 346768 26714 42247723
Cerebral artery thrombosis 20.97 11.04 37 346861 1212 42273225
Product label on wrong product 20.84 11.04 10 346888 49 42274388
Jaundice 20.66 11.04 396 346502 34193 42240244
Product substitution issue 20.63 11.04 160 346738 11130 42263307
Respiratory arrest 20.54 11.04 141 346757 28283 42246154
Diverticulum 20.51 11.04 118 346780 7423 42267014
Feeling abnormal 20.47 11.04 727 346171 69059 42205378
Faeces discoloured 20.33 11.04 220 346678 16794 42257643
Apparent death 20.26 11.04 3 346895 3705 42270732
Mesenteric vein thrombosis 20.23 11.04 31 346867 901 42273536
Angina pectoris 20.12 11.04 378 346520 32518 42241919
Aspergillus infection 20.10 11.04 64 346834 15773 42258664
Thrombotic microangiopathy 20.00 11.04 58 346840 14724 42259713
Deep vein thrombosis 19.53 11.04 789 346109 76168 42198269
Flatulence 19.38 11.04 300 346598 24852 42249585
Therapeutic response decreased 19.34 11.04 200 346698 36812 42237625
Ageusia 19.32 11.04 161 346737 11444 42262993
Insomnia 19.25 11.04 1161 345737 117092 42157345
Blood pH abnormal 19.16 11.04 7 346891 14 42274423
Ventricular fibrillation 19.11 11.04 155 346743 29968 42244469
Septic shock 19.09 11.04 584 346314 91088 42183349
Epstein-Barr virus infection 19.06 11.04 31 346867 9687 42264750
Cerebral infarction 19.04 11.04 162 346736 31007 42243430
Neutropenic sepsis 18.96 11.04 206 346692 15740 42258697
Superinfection 18.95 11.04 60 346838 2891 42271546
Idiopathic pulmonary fibrosis 18.91 11.04 81 346817 4523 42269914
Memory impairment 18.87 11.04 539 346359 49683 42224754
Eye pruritus 18.83 11.04 158 346740 11254 42263183
Lupus endocarditis 18.81 11.04 6 346892 6 42274431
Degenerative mitral valve disease 18.78 11.04 17 346881 276 42274161
Miosis 18.75 11.04 52 346846 13394 42261043
Stoma site haemorrhage 18.59 11.04 33 346865 1086 42273351
Incorrect dose administered 18.58 11.04 311 346587 52663 42221774
Drug effective for unapproved indication 18.53 11.04 16 346882 6617 42267820
Immunosuppressant drug level increased 18.50 11.04 117 346781 7614 42266823
Paraesthesia 18.38 11.04 752 346146 72707 42201730
Extrapyramidal disorder 18.35 11.04 70 346828 16342 42258095
Cerebral atrophy congenital 18.21 11.04 10 346888 68 42274369
Haematotoxicity 18.06 11.04 39 346859 10946 42263491
Syringe issue 18.03 11.04 26 346872 8530 42265907
Acute interstitial pneumonitis 17.89 11.04 23 346875 565 42273872
Cytokine release syndrome 17.79 11.04 255 346643 44272 42230165
Indifference 17.64 11.04 13 346885 155 42274282
Aggression 17.62 11.04 253 346645 43910 42230527
Endophthalmitis 17.60 11.04 7 346891 4426 42270011
Iron deficiency 17.58 11.04 40 346858 11021 42263416
Low birth weight baby 17.50 11.04 34 346864 9921 42264516
Oedematous pancreatitis 17.49 11.04 26 346872 735 42273702
Blood glucose increased 17.43 11.04 750 346148 72949 42201488
Bone erosion 17.41 11.04 7 346891 4396 42270041
Rebound acid hypersecretion 17.40 11.04 11 346887 100 42274337
Hepatocellular injury 17.34 11.04 117 346781 23561 42250876
Diabetic nephropathy 17.29 11.04 50 346848 2291 42272146
Acute graft versus host disease 17.27 11.04 25 346873 8190 42266247
Blood gastrin increased 17.21 11.04 8 346890 36 42274401
Myoclonic dystonia 17.19 11.04 10 346888 77 42274360
Catarrh 17.16 11.04 95 346803 5891 42268546
Chronic kidney disease-mineral and bone disorder 17.08 11.04 20 346878 445 42273992
Genital ulceration 17.08 11.04 28 346870 863 42273574
Activated partial thromboplastin time prolonged 17.04 11.04 69 346829 15834 42258603
Oropharyngeal blistering 17.04 11.04 14 346884 198 42274239
Malignant spinal cord compression 17.01 11.04 12 346886 133 42274304
Hepatitis B reactivation 16.95 11.04 8 346890 4570 42269867
Nephropathy 16.79 11.04 105 346793 6806 42267631
Epiploic appendagitis 16.78 11.04 9 346889 58 42274379
Veillonella infection 16.77 11.04 5 346893 3 42274434
Hyperhidrosis 16.74 11.04 899 345999 89613 42184824
Hepatitis cholestatic 16.73 11.04 137 346761 9687 42264750
Carcinoid tumour of the gastrointestinal tract 16.65 11.04 9 346889 59 42274378
Nephritis 16.61 11.04 68 346830 3721 42270716
Renal fusion anomaly 16.57 11.04 10 346888 83 42274354
Pharyngeal oedema 16.54 11.04 95 346803 5973 42268464
Blood sodium decreased 16.52 11.04 223 346675 17939 42256498
Body temperature decreased 16.42 11.04 61 346837 14352 42260085
Urine calcium decreased 16.42 11.04 6 346892 12 42274425
Oesophageal stenosis 16.39 11.04 45 346853 2001 42272436
Virologic failure 16.37 11.04 6 346892 3988 42270449
Blood calcium decreased 16.36 11.04 150 346748 10958 42263479
Macrocephaly 16.34 11.04 20 346878 467 42273970
Aminoaciduria 16.30 11.04 15 346883 249 42274188
Lipodystrophy acquired 16.29 11.04 4 346894 3446 42270991
Abnormal loss of weight 16.26 11.04 82 346816 4905 42269532
Peripheral sensory neuropathy 16.22 11.04 29 346869 8733 42265704
Device malfunction 16.22 11.04 49 346849 12278 42262159
Ventricular flutter 16.18 11.04 10 346888 87 42274350
Exposure during pregnancy 16.09 11.04 28 346870 8520 42265917
Acute graft versus host disease in intestine 16.09 11.04 6 346892 3945 42270492
Lymphangitis 16.04 11.04 23 346875 629 42273808
Infection 15.98 11.04 747 346151 111321 42163116
Blood copper increased 15.89 11.04 7 346891 27 42274410
Progressive multifocal leukoencephalopathy 15.80 11.04 45 346853 11491 42262946
Amnesia 15.78 11.04 322 346576 28115 42246322
Neuroleptic malignant syndrome 15.77 11.04 106 346792 21366 42253071
Somnolence 15.73 11.04 964 345934 140141 42134296
Accidental death 15.72 11.04 3 346895 3080 42271357
Disinhibition 15.72 11.04 6 346892 3889 42270548
Hypopnoea 15.70 11.04 114 346784 7768 42266669
Cytomegalovirus chorioretinitis 15.68 11.04 9 346889 4602 42269835
Steatorrhoea 15.59 11.04 26 346872 813 42273624
Contusion 15.33 11.04 449 346449 41536 42232901
Forced expiratory volume decreased 15.29 11.04 24 346874 7606 42266831
Transient ischaemic attack 15.24 11.04 371 346527 33368 42241069
Febrile bone marrow aplasia 15.24 11.04 38 346860 10143 42264294
Blood pressure increased 15.22 11.04 676 346222 101252 42173185
Lung opacity 15.22 11.04 15 346883 5822 42268615
Nervous system disorder 15.22 11.04 80 346818 17115 42257322
Catatonia 15.18 11.04 17 346881 6222 42268215
Blister 15.17 11.04 311 346587 27179 42247258
Hospitalisation 15.11 11.04 475 346423 73855 42200582
Nephrosclerosis 15.04 11.04 29 346869 1018 42273419
Nicotine dependence 14.97 11.04 23 346875 670 42273767
Pyloric stenosis 14.95 11.04 27 346871 901 42273536
Inspiratory capacity decreased 14.89 11.04 3 346895 2964 42271473
Pneumonia 14.89 11.04 3759 343139 418390 41856047
Musculoskeletal stiffness 14.88 11.04 357 346541 57408 42217029
Acute myeloid leukaemia recurrent 14.87 11.04 5 346893 3507 42270930
Pancreatitis necrotising 14.84 11.04 64 346834 3585 42270852
Product complaint 14.64 11.04 91 346807 5886 42268551
Peripheral swelling 14.64 11.04 886 346012 89384 42185053
Breath sounds abnormal 14.57 11.04 50 346848 12043 42262394
Shock 14.55 11.04 159 346739 28962 42245475
Device use error 14.53 11.04 4 346894 3193 42271244
Unintentional medical device removal 14.49 11.04 4 346894 3187 42271250
Ischaemic stroke 14.48 11.04 258 346640 21975 42252462
Gastric neoplasm 14.40 11.04 9 346889 80 42274357
Sopor 14.32 11.04 57 346841 13145 42261292
Polymyositis 14.21 11.04 39 346859 1734 42272703
Protein total abnormal 14.18 11.04 17 346881 388 42274049
Posterior reversible encephalopathy syndrome 14.13 11.04 55 346843 12766 42261671
Blood lactate dehydrogenase increased 14.01 11.04 140 346758 25941 42248496
Therapeutic product effect decreased 14.01 11.04 229 346669 38921 42235516
Oxygen saturation decreased 13.98 11.04 410 346488 64277 42210160
Gastric pH decreased 13.97 11.04 12 346886 181 42274256
Alveolitis 13.94 11.04 40 346858 1825 42272612
Leukopenia 13.93 11.04 483 346415 74263 42200174
Oral administration complication 13.92 11.04 8 346890 60 42274377
Psoriasis 13.92 11.04 505 346393 48099 42226338
Tracheobronchitis bacterial 13.87 11.04 7 346891 39 42274398
Urinary tract discomfort 13.87 11.04 10 346888 115 42274322
Ceruloplasmin increased 13.85 11.04 6 346892 22 42274415
Hypothyroidism 13.80 11.04 181 346717 31903 42242534
Therapeutic response shortened 13.78 11.04 60 346838 13494 42260943
Gastroenteritis eosinophilic 13.78 11.04 13 346885 223 42274214
Essential hypertension 13.75 11.04 64 346834 3704 42270733
Joint injury 13.71 11.04 67 346831 14609 42259828
Nausea 13.69 11.04 3530 343368 393269 41881168
Brain abscess 13.68 11.04 9 346889 4275 42270162
Viral mutation identified 13.66 11.04 5 346893 3326 42271111
Immune effector cell-associated neurotoxicity syndrome 13.63 11.04 36 346862 9425 42265012
Gastritis erosive 13.50 11.04 95 346803 6408 42268029
Musculoskeletal chest pain 13.44 11.04 145 346753 11059 42263378
Rales 13.43 11.04 147 346751 11253 42263184
Sleep disorder due to a general medical condition 13.41 11.04 85 346813 17368 42257069
Drug dose omission by device 13.30 11.04 17 346881 5869 42268568
Product substitution error 13.27 11.04 6 346892 25 42274412
Eye injury 13.26 11.04 27 346871 987 42273450
Prescription drug used without a prescription 13.21 11.04 3 346895 2727 42271710
Cholelithiasis 13.17 11.04 265 346633 23081 42251356
Depression 13.17 11.04 1065 345833 110298 42164139
Anaphylactic shock 13.15 11.04 125 346773 23392 42251045
Hypogammaglobulinaemia 13.11 11.04 51 346847 11840 42262597
Occupational exposure to air contaminants 13.08 11.04 11 346887 161 42274276
Pedal pulse decreased 13.08 11.04 5 346893 12 42274425
Choking 13.07 11.04 92 346806 6206 42268231
Non-cardiac chest pain 13.07 11.04 72 346826 4457 42269980
Dry skin 13.06 11.04 499 346399 47839 42226598
Urinary tract infection 12.98 11.04 957 345941 98327 42176110
Parosmia 12.96 11.04 107 346791 7584 42266853
Coronary artery bypass 12.96 11.04 12 346886 4798 42269639
Treatment noncompliance 12.94 11.04 222 346676 37450 42236987
Breast inflammation 12.91 11.04 6 346892 27 42274410
Exposure to toxic agent 12.88 11.04 13 346885 4991 42269446
Gastric xanthoma 12.80 11.04 5 346893 13 42274424
Uveitis 12.76 11.04 36 346862 9222 42265215
Skin toxicity 12.74 11.04 21 346877 6528 42267909
Vasoplegia syndrome 12.69 11.04 3 346895 2652 42271785
Gingival pain 12.66 11.04 115 346783 8379 42266058
Periodontal disease 12.65 11.04 24 346874 832 42273605
Adrenal insufficiency 12.64 11.04 96 346802 18828 42255609
Radiation inflammation 12.64 11.04 27 346871 1021 42273416
Hepatitis B 12.62 11.04 22 346876 6689 42267748
Erosive oesophagitis 12.59 11.04 34 346864 1497 42272940
Constipation 12.58 11.04 1507 345391 160784 42113653
Latent tetany 12.54 11.04 4 346894 4 42274433
Neonatal respiratory distress syndrome 12.47 11.04 11 346887 4502 42269935
Faeces pale 12.44 11.04 35 346863 1579 42272858
Depressive symptom 12.43 11.04 8 346890 3845 42270592
Drug level increased 12.41 11.04 290 346608 25910 42248527
Blood potassium decreased 12.39 11.04 234 346664 20150 42254287
Ectopic gastric mucosa 12.29 11.04 5 346893 15 42274422
Red blood cell analysis abnormal 12.29 11.04 5 346893 15 42274422
Euphoric mood 12.27 11.04 21 346877 6432 42268005
Swelling face 12.15 11.04 302 346596 27252 42247185
Rhinitis 12.13 11.04 150 346748 11827 42262610
Cerebrovascular accident 12.11 11.04 933 345965 96227 42178210
Cytopenia 12.05 11.04 88 346810 17409 42257028
Psychiatric decompensation 12.02 11.04 10 346888 4212 42270225
Abdominal sepsis 12.01 11.04 29 346869 1191 42273246
Agitated depression 11.99 11.04 13 346885 265 42274172
Dermatitis atopic 11.99 11.04 154 346744 12250 42262187
Hyperthermia 11.98 11.04 57 346841 12517 42261920
Electrocardiogram QRS complex prolonged 11.97 11.04 18 346880 5805 42268632
Colorectal cancer 11.96 11.04 14 346884 5024 42269413
Pancreatic pseudocyst 11.96 11.04 24 346874 868 42273569
Intestinal angioedema 11.95 11.04 12 346886 223 42274214
Pleural mass 11.94 11.04 8 346890 81 42274356
Micturition urgency 11.90 11.04 53 346845 11845 42262592
Blindness 11.84 11.04 209 346689 17769 42256668
Necrotising panniculitis 11.81 11.04 7 346891 56 42274381
Psychomotor skills impaired 11.79 11.04 15 346883 5189 42269248
Yellow skin 11.74 11.04 44 346854 2310 42272127
Intermittent claudication 11.72 11.04 46 346852 2469 42271968
Nocardiosis 11.71 11.04 15 346883 5175 42269262
Immune-mediated hepatic disorder 11.70 11.04 3 346895 2511 42271926
Acute graft versus host disease in skin 11.68 11.04 27 346871 7397 42267040
Intestinal fistula infection 11.66 11.04 4 346894 6 42274431
Intestinal infarction 11.60 11.04 19 346879 585 42273852
Abdominal wall disorder 11.57 11.04 9 346889 117 42274320
Product administered to patient of inappropriate age 11.55 11.04 13 346885 4748 42269689
Transaminases increased 11.55 11.04 193 346705 32692 42241745
Palatal swelling 11.51 11.04 7 346891 59 42274378
Acute respiratory distress syndrome 11.48 11.04 174 346724 29934 42244503
Visceral pain 11.47 11.04 8 346890 87 42274350
Anal chlamydia infection 11.46 11.04 3 346895 0 42274437
Aspiration pleural cavity abnormal 11.46 11.04 3 346895 0 42274437
Glossitis 11.39 11.04 32 346866 1442 42272995
Cholecystectomy 11.37 11.04 56 346842 3318 42271119
Post procedural constipation 11.29 11.04 4 346894 7 42274430
Incision site cellulitis 11.29 11.04 4 346894 7 42274430
Portal fibrosis 11.27 11.04 14 346884 332 42274105
Somatosensory evoked potentials abnormal 11.26 11.04 10 346888 158 42274279
Antipsychotic drug level below therapeutic 11.26 11.04 6 346892 3198 42271239
No adverse event 11.23 11.04 237 346661 38784 42235653
Renal haemangioma 11.21 11.04 5 346893 20 42274417
Visual impairment 11.16 11.04 443 346455 42670 42231767
Cerebral vasoconstriction 11.13 11.04 12 346886 243 42274194
Pharyngeal dystonia 11.13 11.04 7 346891 63 42274374
Blood pressure diastolic decreased 11.12 11.04 45 346853 10330 42264107
Hallucination, auditory 11.11 11.04 73 346825 14791 42259646
Psoriatic arthropathy 11.05 11.04 140 346758 24827 42249610
Amino acid level increased 11.04 11.04 17 346881 496 42273941

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypomagnesaemia 2015.53 9.81 2216 716398 58154 109812531
Synovitis 1445.58 9.81 83 718531 274009 109596676
Hand deformity 1227.81 9.81 43 718571 218463 109652222
Pemphigus 1224.29 9.81 37 718577 214533 109656152
Anti-cyclic citrullinated peptide antibody positive 1125.77 9.81 10 718604 181974 109688711
Drug intolerance 1115.63 9.81 627 717987 405885 109464800
Drug ineffective 1077.96 9.81 5663 712951 1514877 108355808
Drug interaction 997.53 9.81 6102 712512 494081 109376604
Duodenal ulcer perforation 977.71 9.81 41 718573 177659 109693026
Wound 910.44 9.81 204 718410 234233 109636452
Off label use 906.78 9.81 5879 712735 1494306 108376379
Treatment failure 899.39 9.81 338 718276 276896 109593789
Glossodynia 866.50 9.81 191 718423 221813 109648872
Hypocalcaemia 861.47 9.81 1534 717080 63832 109806853
Helicobacter infection 848.18 9.81 95 718519 181782 109688903
Folliculitis 839.10 9.81 66 718548 167587 109703098
Tubulointerstitial nephritis 827.43 9.81 1359 717255 52925 109817760
Systemic lupus erythematosus 823.47 9.81 311 718303 254027 109616658
Rheumatoid factor positive 797.01 9.81 11 718603 131629 109739056
Contraindicated product administered 791.46 9.81 311 718303 247956 109622729
Infusion related reaction 788.36 9.81 788 717826 380374 109490311
Rheumatic fever 761.63 9.81 6 718608 122573 109748112
Muscle injury 759.81 9.81 37 718577 140770 109729915
C-reactive protein abnormal 733.82 9.81 24 718590 129671 109741014
Hyponatraemia 728.68 9.81 3074 715540 214579 109656106
Maternal exposure during pregnancy 674.90 9.81 410 718204 254473 109616212
Acute kidney injury 671.04 9.81 6688 711926 628742 109241943
Hepatic enzyme increased 641.24 9.81 683 717931 320209 109550476
Pericarditis 621.02 9.81 324 718290 218790 109651895
Sleep disorder due to general medical condition, insomnia type 603.24 9.81 18 718596 105625 109765060
Therapeutic product effect decreased 583.89 9.81 440 718174 243876 109626809
Facet joint syndrome 554.71 9.81 16 718598 96812 109773873
Arthropathy 550.20 9.81 634 717980 286888 109583797
Impaired healing 544.10 9.81 300 718314 196417 109674268
Drug hypersensitivity 523.68 9.81 1380 717234 452710 109417975
Irritable bowel syndrome 514.59 9.81 211 718403 164004 109706681
Joint swelling 512.82 9.81 1343 717271 441502 109429183
Swollen joint count increased 510.80 9.81 6 718608 83655 109787030
Psoriatic arthropathy 509.05 9.81 325 718289 196436 109674249
Chronic kidney disease 498.69 9.81 1350 717264 74941 109795744
Lip dry 480.11 9.81 47 718567 100036 109770649
Fibromyalgia 475.03 9.81 259 718355 170650 109700035
Breast cancer stage III 468.88 9.81 9 718605 79108 109791577
Type 2 diabetes mellitus 430.09 9.81 314 718300 176918 109693767
Bursitis 420.09 9.81 159 718455 129759 109740926
Joint range of motion decreased 419.95 9.81 134 718480 121698 109748987
Ill-defined disorder 405.82 9.81 259 718355 156594 109714091
Therapeutic product effect incomplete 396.01 9.81 524 718090 223281 109647404
Discomfort 381.62 9.81 501 718113 214206 109656479
Rheumatoid arthritis 364.95 9.81 885 717729 298728 109571957
Product use issue 361.57 9.81 944 717670 310751 109559934
Swelling 355.45 9.81 1134 717480 349907 109520778
Diarrhoea 350.88 9.81 9784 708830 1129721 108740964
Stomatitis 342.10 9.81 782 717832 269460 109601225
Grip strength decreased 340.23 9.81 56 718558 80118 109790567
Hypersensitivity 339.82 9.81 1410 717204 402588 109468097
Subacute cutaneous lupus erythematosus 338.78 9.81 272 718342 4722 109865963
Alopecia 321.92 9.81 1249 717365 363504 109507181
Hypokalaemia 319.00 9.81 2155 716459 180293 109690392
Peripheral venous disease 316.88 9.81 78 718536 84039 109786646
General physical health deterioration 315.40 9.81 1555 717059 423740 109446945
Blood cholesterol increased 309.48 9.81 450 718164 184335 109686350
Deep vein thrombosis postoperative 303.27 9.81 21 718593 59270 109811415
Wound infection 300.46 9.81 125 718489 96340 109774345
Liver injury 299.27 9.81 321 718293 150092 109720593
Live birth 293.81 9.81 49 718565 69435 109801250
Musculoskeletal stiffness 292.34 9.81 891 717723 278931 109591754
Product use in unapproved indication 291.19 9.81 1709 716905 445668 109425017
Exposure during pregnancy 288.03 9.81 400 718214 167024 109703661
Nasopharyngitis 273.12 9.81 1476 717138 392885 109477800
Orthostatic hypotension 261.84 9.81 986 717628 65263 109805422
Autoimmune disorder 254.02 9.81 57 718557 65426 109805259
Blood calcium decreased 253.21 9.81 653 717961 35192 109835493
Blepharospasm 252.25 9.81 30 718584 54821 109815864
Cognitive disorder 248.13 9.81 1177 717437 86334 109784351
Balance disorder 240.36 9.81 1436 717178 115124 109755561
Intentional product use issue 239.67 9.81 817 717797 247089 109623596
Creatinine renal clearance decreased 238.80 9.81 473 718141 21342 109849343
Adjustment disorder with depressed mood 238.40 9.81 11 718603 43872 109826813
Lung disorder 237.63 9.81 509 718105 179538 109691147
Dislocation of vertebra 237.39 9.81 11 718603 43710 109826975
Constipation 235.90 9.81 3446 715168 354340 109516345
Inflammation 235.03 9.81 571 718043 192667 109678018
Lip swelling 231.71 9.81 791 717823 49876 109820809
Drug abuse 229.64 9.81 507 718107 176904 109693781
Obesity 228.73 9.81 239 718375 113112 109757573
Blister 226.20 9.81 740 717874 226636 109644049
Infection 223.34 9.81 1407 717207 360793 109509892
Osteoarthritis 217.12 9.81 546 718068 182077 109688608
Bone erosion 216.65 9.81 24 718590 46347 109824338
Myalgia 214.06 9.81 2299 716315 220082 109650603
Injury 210.72 9.81 530 718084 176735 109693950
Prescribed overdose 210.04 9.81 157 718457 87424 109783261
Weight increased 203.13 9.81 1746 716868 417898 109452787
X-ray abnormal 202.47 9.81 11 718603 38106 109832579
Hypercholesterolaemia 200.20 9.81 177 718437 90660 109780025
Sciatica 196.56 9.81 186 718428 92213 109778472
Tetany 196.39 9.81 173 718441 3431 109867254
Hypoparathyroidism 196.35 9.81 123 718491 1407 109869278
Lupus vulgaris 196.28 9.81 5 718609 33878 109836807
Condition aggravated 194.28 9.81 3483 715131 731353 109139332
Lower limb fracture 191.33 9.81 127 718487 75221 109795464
Gastrointestinal haemorrhage 191.12 9.81 1777 716837 163741 109706944
Dehydration 189.67 9.81 2706 715908 276805 109593880
Onychomadesis 189.11 9.81 34 718580 45629 109825056
Fall 186.34 9.81 5187 713427 598295 109272390
Sedation complication 185.08 9.81 403 718211 19452 109851233
Nail disorder 180.53 9.81 75 718539 57860 109812825
C-reactive protein 177.53 9.81 4 718610 30327 109840358
Gastrointestinal disorder 177.25 9.81 888 717726 241064 109629621
Wheezing 175.07 9.81 958 717656 254272 109616413
Retinitis 172.74 9.81 9 718605 32318 109838367
Therapy non-responder 172.09 9.81 490 718124 156817 109713868
Hallucination 171.79 9.81 1189 717425 100243 109770442
Drug ineffective for unapproved indication 169.64 9.81 253 718361 102585 109768100
Myelosuppression 164.63 9.81 223 718391 94117 109776568
Dyspnoea 164.13 9.81 8774 709840 1098098 108772587
Night sweats 162.82 9.81 396 718218 133587 109737098
Hypertrichosis 160.82 9.81 115 718499 1663 109869022
Syncope 160.16 9.81 2016 716598 200520 109670165
Lethargy 159.11 9.81 1098 717516 92478 109778207
Inappropriate antidiuretic hormone secretion 158.77 9.81 533 718081 33318 109837367
Renal failure 158.69 9.81 2206 716408 224368 109646317
Gastritis 157.89 9.81 730 717884 52969 109817716
Palpitations 157.86 9.81 1656 716958 157556 109713129
Liver function test abnormal 156.17 9.81 871 717743 68079 109802606
Musculoskeletal pain 155.42 9.81 636 717978 182387 109688298
Abdominal discomfort 152.69 9.81 1729 716885 392129 109478556
Plasma cell myeloma 147.21 9.81 802 717812 62134 109808551
Sinusitis 146.36 9.81 1228 717386 295460 109575225
Urinary tract infection 146.05 9.81 2953 715661 323329 109547356
Red blood cell sedimentation rate increased 146.05 9.81 176 718438 78126 109792559
Liver disorder 145.56 9.81 457 718157 141786 109728899
Breast cancer stage II 145.09 9.81 8 718606 27367 109843318
Abdominal pain 142.55 9.81 4352 714262 508637 109362048
Road traffic accident 141.36 9.81 304 718310 107094 109763591
Tinnitus 141.28 9.81 771 717843 59769 109810916
Coeliac disease 141.01 9.81 52 718562 43135 109827550
Finger deformity 140.65 9.81 23 718591 33069 109837616
Pregnancy 139.50 9.81 79 718535 50988 109819697
Drug resistance 139.15 9.81 98 718516 56276 109814409
Cholecystitis chronic 136.91 9.81 232 718382 9268 109861417
C-reactive protein increased 136.05 9.81 843 717771 217076 109653609
Adverse event 135.86 9.81 317 718297 108492 109762193
International normalised ratio increased 132.96 9.81 993 717621 85779 109784906
Cardiospasm 131.64 9.81 162 718452 4805 109865880
Dizziness 130.78 9.81 5665 712949 692528 109178157
Infective pulmonary exacerbation of cystic fibrosis 127.77 9.81 291 718323 14480 109856205
Palmoplantar keratoderma 127.40 9.81 166 718448 5221 109865464
Sleep disorder 127.37 9.81 762 717852 197882 109672803
Nausea 126.59 9.81 9488 709126 1226202 108644483
Transient ischaemic attack 124.74 9.81 777 717837 63205 109807480
Red blood cell sedimentation rate abnormal 124.42 9.81 9 718605 24500 109846185
Deep vein thrombosis 123.95 9.81 1423 717191 138464 109732221
Atrial fibrillation 123.35 9.81 2138 716476 227504 109643181
Gastric polyps 122.61 9.81 165 718449 5358 109865327
Drug tolerance decreased 119.63 9.81 18 718596 27522 109843163
Swollen tongue 119.53 9.81 736 717878 59626 109811059
Pulmonary embolism 119.26 9.81 2008 716606 212466 109658219
Maternal exposure timing unspecified 118.43 9.81 4 718610 21009 109849676
Completed suicide 117.82 9.81 1007 717607 241374 109629311
Product formulation issue 117.73 9.81 85 718529 1249 109869436
Hip arthroplasty 116.79 9.81 114 718500 55699 109814986
Angioedema 116.43 9.81 1063 717551 97437 109773248
Hiatus hernia 115.03 9.81 418 718196 27188 109843497
Pruritus genital 112.74 9.81 173 718441 6349 109864336
Gait inability 112.60 9.81 479 718135 135897 109734788
Vomiting 111.39 9.81 7097 711517 903578 108967107
Therapy partial responder 110.69 9.81 51 718563 37010 109833675
Exostosis 106.85 9.81 85 718529 45871 109824814
Prescribed underdose 106.84 9.81 161 718453 65013 109805672
Pulmonary fibrosis 106.41 9.81 325 718289 101717 109768968
Anaemia 106.17 9.81 4456 714158 542630 109328055
Back injury 106.08 9.81 91 718523 47308 109823377
Haematemesis 104.91 9.81 701 717913 58407 109812278
Taste disorder 104.81 9.81 164 718450 65223 109805462
Lower respiratory tract infection 104.75 9.81 1041 717573 242065 109628620
Back pain 104.18 9.81 3152 715462 367844 109502841
Cerebrovascular accident 103.62 9.81 1705 716909 179579 109691106
Upper gastrointestinal haemorrhage 103.11 9.81 617 717997 49479 109821206
Feeling abnormal 103.06 9.81 1699 716915 179012 109691673
Atrial tachycardia 102.87 9.81 201 718413 8977 109861708
Rhabdomyolysis 102.31 9.81 1215 717399 119186 109751499
Tension headache 102.22 9.81 206 718408 9412 109861273
Carotid artery occlusion 101.82 9.81 205 718409 9360 109861325
Sleep terror 98.69 9.81 164 718450 6446 109864239
Tremor 98.43 9.81 1854 716760 200378 109670307
Epilepsy 98.31 9.81 328 718286 99881 109770804
Haemoglobin decreased 97.35 9.81 2208 716406 246519 109624166
Disorientation 96.25 9.81 787 717827 69884 109800801
Asthenia 95.13 9.81 5428 713186 683571 109187114
Vision blurred 94.69 9.81 1267 717347 127755 109742930
Pancreatitis acute 94.17 9.81 693 717921 59581 109811104
Chest pain 93.22 9.81 3150 715464 373225 109497460
Porphyria acute 92.24 9.81 8 718606 18772 109851913
Dysgeusia 91.38 9.81 772 717842 69213 109801472
Therapeutic response decreased 87.87 9.81 326 718288 96173 109774512
Hypotension 87.85 9.81 4204 714410 519645 109351040
Gastric pH decreased 87.20 9.81 64 718550 966 109869719
Blood sodium decreased 84.74 9.81 481 718133 37838 109832847
Renal injury 84.55 9.81 291 718323 18422 109852263
Rheumatoid nodule 84.29 9.81 15 718599 20281 109850404
Normal newborn 83.05 9.81 20 718594 21876 109848809
Incorrect route of product administration 82.91 9.81 183 718431 63878 109806807
Onychomycosis 82.60 9.81 77 718537 38454 109832231
Hyperhidrosis 82.35 9.81 1691 716923 185607 109685078
Chromaturia 81.82 9.81 393 718221 28967 109841718
Blood magnesium decreased 81.82 9.81 301 718313 19695 109850990
Facial pain 81.43 9.81 252 718362 15087 109855598
Oesophagitis 81.21 9.81 386 718228 28329 109842356
Mobility decreased 81.03 9.81 1071 717543 236351 109634334
Hypoaesthesia 81.02 9.81 1495 717119 312728 109557957
Adverse reaction 80.52 9.81 46 718568 29548 109841137
Jaundice 80.31 9.81 659 717955 58577 109812108
Impaired quality of life 80.22 9.81 397 718217 29620 109841065
Liver function test increased 79.41 9.81 301 718313 88247 109782438
Swelling face 79.03 9.81 933 717681 91388 109779297
Immunisation 78.27 9.81 100 718514 3083 109867602
Anosmia 75.82 9.81 215 718399 12257 109858428
Toxic epidermal necrolysis 75.79 9.81 629 717985 56098 109814587
End stage renal disease 74.64 9.81 307 718307 21166 109849519
Blood pressure systolic increased 73.85 9.81 283 718331 82708 109787977
Hypoglycaemia 73.53 9.81 1111 717503 114993 109755692
Neutropenic sepsis 72.70 9.81 393 718221 30353 109840332
Hypertension 72.56 9.81 2647 715967 507437 109363248
Flatulence 71.69 9.81 582 718032 51567 109819118
Dry skin 71.25 9.81 1038 717576 106615 109764070
Muscle twitching 70.35 9.81 382 718232 29553 109841132
Subarachnoid haemorrhage 69.79 9.81 379 718235 29323 109841362
Hypoparathyroidism secondary 69.26 9.81 35 718579 254 109870431
Disturbance in attention 68.72 9.81 660 717954 61335 109809350
Foot deformity 68.23 9.81 132 718482 48348 109822337
Product dose omission issue 67.88 9.81 2645 715969 319137 109551548
Dysphagia 67.59 9.81 1387 717227 152213 109718472
Labelled drug-drug interaction medication error 67.57 9.81 372 718242 28930 109841755
Eosinophilic oesophagitis 67.56 9.81 61 718553 1251 109869434
Hypertensive nephropathy 67.17 9.81 55 718559 983 109869702
Blood alkaline phosphatase increased 66.63 9.81 730 717884 70205 109800480
Obstructive airways disorder 66.40 9.81 124 718490 46025 109824660
Blood pressure diastolic abnormal 66.22 9.81 43 718571 25772 109844913
Urticaria 65.48 9.81 1574 717040 317283 109553402
Infusion site reaction 65.42 9.81 17 718597 17665 109853020
Faeces discoloured 63.51 9.81 408 718206 33540 109837145
Toxicity to various agents 61.28 9.81 2526 716088 478029 109392656
Blood glucose increased 60.81 9.81 1204 717410 131292 109739393
Iron deficiency anaemia 60.10 9.81 381 718233 31178 109839507
Sedation 59.98 9.81 705 717909 68978 109801707
Rash papular 59.84 9.81 345 718269 27294 109843391
Laryngitis 59.23 9.81 116 718498 42295 109828390
Chest discomfort 58.82 9.81 1513 717101 172335 109698350
Electrocardiogram QT prolonged 58.66 9.81 1015 717599 107945 109762740
Gallbladder disorder 58.25 9.81 281 718333 20748 109849937
Insulin autoimmune syndrome 58.11 9.81 44 718570 698 109869987
Melaena 57.58 9.81 692 717922 68065 109802620
Parosmia 56.98 9.81 202 718412 12978 109857707
Drug use disorder 56.95 9.81 23 718591 18051 109852634
Oedema 56.95 9.81 990 717624 208986 109661699
Peripheral swelling 56.90 9.81 2099 716515 401935 109468750
Electrolyte imbalance 56.29 9.81 423 718191 36605 109834080
Tenosynovitis 55.93 9.81 18 718596 16265 109854420
Abnormal loss of weight 55.84 9.81 170 718444 10087 109860598
Coma 55.77 9.81 493 718121 117376 109753309
Cough 55.20 9.81 3592 715022 458049 109412636
Dry mouth 55.10 9.81 940 717674 199008 109671677
Blood potassium decreased 55.08 9.81 566 718048 53548 109817137
Agitation 54.83 9.81 1036 717578 112015 109758670
Chronic obstructive pulmonary disease 54.56 9.81 1005 717609 108153 109762532
Seronegative arthritis 54.16 9.81 10 718604 13167 109857518
Aplastic anaemia 53.99 9.81 47 718567 24261 109846424
Hepatic encephalopathy 53.73 9.81 341 718273 27915 109842770
Myocardial infarction 53.59 9.81 1631 716983 190452 109680233
Product substitution issue 53.33 9.81 293 718321 22768 109847917
Oral pain 53.16 9.81 421 718193 37023 109833662
Underdose 52.59 9.81 223 718391 63331 109807354
Walking aid user 51.56 9.81 52 718562 25023 109845662
Pain of skin 51.47 9.81 262 718352 19767 109850918
Feeling of despair 51.13 9.81 90 718524 3708 109866977
Mouth swelling 50.93 9.81 133 718481 7221 109863464
Device expulsion 50.93 9.81 76 718538 30815 109839870
Blindness 50.64 9.81 407 718207 35952 109834733
Multiple-drug resistance 50.37 9.81 12 718602 13223 109857462
Biliary dyskinesia 50.23 9.81 70 718544 2351 109868334
Acute myocardial infarction 50.11 9.81 794 717820 82983 109787702
Joint dislocation 49.96 9.81 91 718523 34099 109836586
Presyncope 49.60 9.81 511 718103 48376 109822309
Blood pressure systolic abnormal 49.44 9.81 53 718561 24797 109845888
Loss of personal independence in daily activities 49.26 9.81 682 717932 149338 109721347
Blood pressure fluctuation 49.01 9.81 285 718329 74539 109796146
Nephrogenic anaemia 48.60 9.81 98 718516 4479 109866206
Joint stiffness 48.51 9.81 248 718366 66995 109803690
Vertigo 48.12 9.81 813 717801 86057 109784628
Rash macular 47.49 9.81 421 718193 38265 109832420
Mania 47.27 9.81 263 718351 20533 109850152
Pulmonary pain 46.89 9.81 117 718497 6176 109864509
Depersonalisation/derealisation disorder 46.66 9.81 64 718550 2117 109868568
Female genital tract fistula 45.92 9.81 25 718589 16494 109854191
Panniculitis 45.67 9.81 22 718592 15560 109855125
Loss of consciousness 45.30 9.81 1630 716984 194676 109676009
Nightmare 45.20 9.81 418 718196 38445 109832240
Cogwheel rigidity 45.16 9.81 84 718530 3614 109867071
Foetal death 45.01 9.81 24 718590 16021 109854664
Pneumonitis 44.89 9.81 723 717891 75808 109794877
Blood urea increased 44.67 9.81 550 718064 54407 109816278
Epistaxis 44.50 9.81 1136 717478 129236 109741449
Suicide attempt 44.40 9.81 443 718171 102951 109767734
Feeling of body temperature change 43.97 9.81 113 718501 6075 109864610
Hyperkalaemia 43.38 9.81 1173 717441 134623 109736062
Intentional overdose 43.27 9.81 603 718011 131898 109738787
Eye pruritus 43.02 9.81 362 718252 32413 109838272
Circulatory collapse 42.96 9.81 448 718166 42545 109828140
Occupational dermatitis 42.79 9.81 21 718593 142 109870543
Diverticulum 42.67 9.81 207 718407 15319 109855366
Restless legs syndrome 42.46 9.81 290 718324 24336 109846349
Injection site reaction 42.38 9.81 372 718242 88698 109781987
Knee arthroplasty 42.20 9.81 248 718366 64700 109805985
Non-cardiac chest pain 42.13 9.81 154 718460 10044 109860641
Chronic sinusitis 42.05 9.81 61 718553 25023 109845662
Hepatitis cholestatic 41.85 9.81 225 718389 17341 109853344
Mucormycosis 41.72 9.81 9 718605 10619 109860066
Joint destruction 41.50 9.81 10 718604 10933 109859752
Respiratory symptom 40.99 9.81 23 718591 14922 109855763
Multimorbidity 40.97 9.81 50 718564 1470 109869215
Metabolic alkalosis 40.62 9.81 103 718511 5492 109865193
Immune reconstitution inflammatory syndrome 40.32 9.81 28 718586 16198 109854487
Poisoning 40.30 9.81 80 718534 29025 109841660
Disability 40.22 9.81 85 718529 30138 109840547
Haemophagocytic lymphohistiocytosis 40.14 9.81 91 718523 31468 109839217
Pulmonary malformation 40.01 9.81 23 718591 222 109870463
Seizure 39.99 9.81 1789 716825 219396 109651289
H1N1 influenza 39.96 9.81 71 718543 2947 109867738
Derealisation 39.80 9.81 59 718555 2099 109868586
Proctitis 39.74 9.81 31 718583 16896 109853789
Catatonia 39.69 9.81 12 718602 11288 109859397
Bone pain 39.59 9.81 619 717995 64514 109806171
Cardiac failure congestive 39.43 9.81 1272 717342 149728 109720957
Temperature regulation disorder 39.32 9.81 17 718597 12809 109857876
Diplopia 39.28 9.81 431 718183 41463 109829222
Hallucinations, mixed 39.11 9.81 135 718479 8558 109862127
Product complaint 38.91 9.81 187 718427 13785 109856900
Ventricular tachycardia 38.73 9.81 496 718118 49513 109821172
Hypophosphataemia 38.64 9.81 357 718257 32825 109837860
Skin discolouration 38.64 9.81 488 718126 48558 109822127
Pneumonia 38.60 9.81 6370 712244 870344 109000341
Depressed level of consciousness 38.21 9.81 978 717636 111300 109759385
Parkinsonism 38.09 9.81 261 718353 21926 109848759
Essential hypertension 38.08 9.81 125 718489 7722 109862963
Colitis ischaemic 38.06 9.81 221 718393 17529 109853156
Muscle spasticity 37.71 9.81 114 718500 35801 109834884
Cerebellar syndrome 37.69 9.81 108 718506 6194 109864491
BK virus infection 37.66 9.81 19 718595 13087 109857598
Malaise 37.60 9.81 4949 713665 666870 109203815
Enthesopathy 37.53 9.81 17 718597 12461 109858224
Urinary retention 37.45 9.81 649 717965 69034 109801651
Rectal haemorrhage 37.39 9.81 1032 717582 118801 109751884
Burning sensation 37.34 9.81 645 717969 68567 109802118
Confusional state 37.11 9.81 3532 715082 465148 109405537
Hypophagia 37.04 9.81 513 718101 52113 109818572
Drug-induced liver injury 36.90 9.81 553 718061 119514 109751171
Angina pectoris 36.72 9.81 589 718025 61706 109808979
Drooling 36.71 9.81 116 718498 7023 109863662
Cytomegalovirus infection reactivation 36.58 9.81 39 718575 18294 109852391
Sepsis 36.41 9.81 2532 716082 324814 109545871
Abdominal tenderness 36.36 9.81 169 718445 12288 109858397
Cytomegalovirus viraemia 36.34 9.81 37 718577 17727 109852958
Post transplant lymphoproliferative disorder 36.14 9.81 29 718585 15584 109855101
Malignant neoplasm progression 36.01 9.81 861 717753 173706 109696979
Acute respiratory failure 35.91 9.81 688 717926 74572 109796113
Clostridium difficile infection 35.82 9.81 506 718108 51623 109819062
Dermatitis atopic 35.62 9.81 286 718328 25255 109845430
Renal tubular acidosis 35.49 9.81 88 718526 4627 109866058
Malabsorption 35.45 9.81 107 718507 6318 109864367
Hypoaesthesia oral 35.36 9.81 210 718404 16792 109853893
Lower gastrointestinal haemorrhage 35.09 9.81 223 718391 18263 109852422
Neutrophil count increased 35.06 9.81 362 718252 34290 109836395
Palatal oedema 35.04 9.81 49 718565 1651 109869034
Genital ulceration 35.00 9.81 53 718561 1922 109868763
Catarrh 34.84 9.81 116 718498 7219 109863466
Pathogen resistance 34.81 9.81 38 718576 17634 109853051
Drug level increased 34.74 9.81 468 718146 47251 109823434
Vaginal discharge 34.74 9.81 39 718575 17869 109852816
Cholelithiasis 34.56 9.81 592 718022 62830 109807855
Arthralgia 34.43 9.81 4489 714125 775143 109095542
Vitamin B12 deficiency 34.35 9.81 143 718471 9912 109860773
Device difficult to use 34.29 9.81 43 718571 18762 109851923
Frequent bowel movements 34.03 9.81 298 718316 71092 109799593
Dialysis 33.80 9.81 231 718383 19388 109851297
Burning mouth syndrome 33.77 9.81 31 718583 650 109870035
Stevens-Johnson syndrome 33.75 9.81 459 718155 46442 109824243
Pancreatitis 33.69 9.81 821 717793 92712 109777973
Rash 33.63 9.81 4749 713865 816215 109054470
Barrett's oesophagus 33.50 9.81 31 718583 657 109870028
Substance use disorder 33.49 9.81 4 718610 7286 109863399
Gastric mucosal hypertrophy 33.16 9.81 23 718591 316 109870369
Premature delivery 33.05 9.81 96 718518 30536 109840149
Blood creatine phosphokinase increased 32.83 9.81 662 717952 72415 109798270
Hyperchlorhydria 32.63 9.81 54 718560 2115 109868570
Cholecystectomy 32.55 9.81 148 718466 10661 109860024
Immunodeficiency 32.30 9.81 136 718478 38702 109831983
Rebound acid hypersecretion 32.14 9.81 16 718598 112 109870573
Asthma 31.99 9.81 1315 717299 248976 109621709
Epstein-Barr virus infection 31.97 9.81 45 718569 18693 109851992
Malignant mediastinal neoplasm 31.87 9.81 42 718572 1336 109869349
Spondylitis 31.75 9.81 17 718597 11321 109859364
Dilatation intrahepatic duct acquired 31.74 9.81 33 718581 810 109869875
Dementia 31.63 9.81 330 718284 31343 109839342
Ageusia 31.33 9.81 227 718387 19418 109851267
Hip fracture 31.30 9.81 358 718256 34793 109835892
Genital blister 31.27 9.81 19 718595 205 109870480
Muscle disorder 31.23 9.81 105 718509 6567 109864118
Overlap syndrome 31.14 9.81 10 718604 9049 109861636
Pharyngeal oedema 31.08 9.81 198 718416 16230 109854455
Right hemisphere deficit syndrome 30.98 9.81 10 718604 16 109870669
Long QT syndrome 30.69 9.81 109 718505 7009 109863676
Graft versus host disease in gastrointestinal tract 30.65 9.81 10 718604 8958 109861727
Pancreatic abscess 30.53 9.81 18 718596 183 109870502
Odynophagia 30.52 9.81 176 718438 13925 109856760
Brain scan abnormal 30.49 9.81 44 718570 1527 109869158
Atrioventricular block first degree 30.43 9.81 177 718437 14048 109856637
Occult blood positive 30.40 9.81 112 718502 7333 109863352
Poisoning deliberate 30.29 9.81 80 718534 26251 109844434
Oedematous pancreatitis 30.19 9.81 45 718569 1609 109869076
Cross sensitivity reaction 30.05 9.81 92 718522 5475 109865210
Gingival pain 29.98 9.81 190 718424 15546 109855139
Dysuria 29.90 9.81 554 718060 59677 109811008
Polymyositis 29.83 9.81 71 718543 3637 109867048
Hepatic cirrhosis 29.76 9.81 288 718326 67338 109803347
Abdominal pain upper 29.74 9.81 2645 715969 346466 109524219
Tongue discomfort 29.68 9.81 61 718553 2827 109867858
Ear infection 29.40 9.81 263 718351 62469 109808216
Respiratory disorder 29.34 9.81 309 718305 71073 109799612
Cardiogenic shock 29.29 9.81 235 718379 57103 109813582
Sleep disorder due to a general medical condition 29.27 9.81 208 718406 51904 109818781
Duodenitis 29.27 9.81 128 718486 9068 109861617
Urinary incontinence 29.24 9.81 461 718153 48126 109822559
Calcium deficiency 28.85 9.81 37 718577 1145 109869540
Drug dose omission by device 28.83 9.81 31 718583 14485 109856200
Cytomegalovirus infection 28.81 9.81 221 718393 54223 109816462
Nasal polyps 28.74 9.81 26 718588 13174 109857511
Supraventricular tachycardia 28.56 9.81 263 718351 24159 109846526
Oesophageal stenosis 28.49 9.81 86 718528 5079 109865606
Intercepted product preparation error 28.41 9.81 5 718609 6815 109863870
Contusion 28.36 9.81 1233 717381 232128 109638557
Hyperphosphataemia 28.29 9.81 39 718575 16342 109854343
Tetanus 28.23 9.81 12 718602 55 109870630
Blood chromogranin A increased 28.15 9.81 29 718585 704 109869981
Drug tolerance 28.13 9.81 40 718574 16545 109854140
Gastroenteritis 28.03 9.81 380 718234 38420 109832265
Mycotic allergy 28.02 9.81 3 718611 5951 109864734
Total lung capacity decreased 27.98 9.81 6 718608 7108 109863577
Pulmonary toxicity 27.97 9.81 45 718569 17701 109852984
Tongue oedema 27.88 9.81 117 718497 8139 109862546
Gallbladder injury 27.86 9.81 38 718576 1250 109869435
Cystitis haemorrhagic 27.86 9.81 23 718591 12186 109858499
Lung opacity 27.79 9.81 21 718593 11631 109859054
Distributive shock 27.72 9.81 3 718611 5901 109864784
Atrioventricular block complete 27.53 9.81 224 718390 19858 109850827
Device dependence 27.40 9.81 12 718602 60 109870625
Macular degeneration 27.11 9.81 63 718551 21596 109849089
Haematuria 27.08 9.81 719 717895 82286 109788399
Cholecystitis 26.96 9.81 272 718342 25610 109845075
Amyloid arthropathy 26.87 9.81 43 718571 1637 109869048
Overdose 26.84 9.81 1243 717371 232551 109638134
Skin exfoliation 26.82 9.81 753 717861 86898 109783787
Type I hypersensitivity 26.80 9.81 97 718517 6296 109864389
Emotional distress 26.80 9.81 425 718189 44422 109826263
Metastases to lymph nodes 26.76 9.81 35 718579 14997 109855688
Chronic graft versus host disease 26.75 9.81 14 718600 9443 109861242
Muscle rigidity 26.71 9.81 256 718358 23775 109846910
Haemodialysis 26.69 9.81 202 718412 17517 109853168
Blood pressure diastolic decreased 26.65 9.81 131 718483 35754 109834931
Hypopnoea 26.59 9.81 145 718469 11235 109859450
Jejunal ulcer perforation 26.57 9.81 14 718600 112 109870573
Mouth ulceration 26.47 9.81 450 718164 47688 109822997
Burns second degree 26.44 9.81 110 718504 7623 109863062
Device use error 26.39 9.81 13 718601 9076 109861609
Idiopathic pulmonary fibrosis 26.37 9.81 82 718532 4922 109865763
Panic attack 26.34 9.81 296 718318 28644 109842041
Myocardial ischaemia 26.16 9.81 277 718337 26407 109844278
Acute graft versus host disease 26.16 9.81 27 718587 12854 109857831
Duodenal stenosis 26.11 9.81 32 718582 945 109869740
Polyuria 26.04 9.81 201 718413 17537 109853148
Diabetic nephropathy 25.91 9.81 65 718549 3443 109867242
Dust allergy 25.89 9.81 4 718610 5997 109864688
Mood swings 25.85 9.81 244 718370 22568 109848117
Heart rate decreased 25.82 9.81 380 718234 82376 109788309
Neuritis 25.73 9.81 8 718606 7391 109863294
Cerebral artery thrombosis 25.73 9.81 42 718572 1626 109869059
Systemic infection 25.67 9.81 16 718598 9803 109860882
Unintentional medical device removal 25.55 9.81 13 718601 8910 109861775
Graft versus host disease in skin 25.21 9.81 11 718603 8243 109862442
Acute generalised exanthematous pustulosis 25.19 9.81 233 718381 21431 109849254
Blood gastrin increased 25.12 9.81 11 718603 55 109870630
Truncus coeliacus thrombosis 25.09 9.81 8 718606 12 109870673
Throat tightness 25.03 9.81 330 718284 33159 109837526
Human herpesvirus 6 infection 24.98 9.81 6 718608 6575 109864110
Abortion spontaneous 24.97 9.81 126 718488 34156 109836529
Cellulitis 24.95 9.81 1029 717585 124987 109745698
Vasoplegia syndrome 24.94 9.81 3 718611 5436 109865249
Polyomavirus-associated nephropathy 24.94 9.81 11 718603 8190 109862495
Oral mucosal blistering 24.92 9.81 110 718504 7824 109862861
Tongue blistering 24.92 9.81 45 718569 1892 109868793
Lung cyst 24.83 9.81 23 718591 488 109870197
Emotional disorder 24.78 9.81 185 718429 15975 109854710
Chills 24.78 9.81 1494 717120 189086 109681599
Sopor 24.58 9.81 138 718476 36408 109834277
Headache 24.35 9.81 6268 712346 876109 108994576
Coronary artery disease 24.26 9.81 624 717990 71066 109799619
Adverse drug reaction 24.22 9.81 512 718102 105047 109765638
Food allergy 24.19 9.81 59 718555 19889 109850796
Product quality issue 24.10 9.81 355 718259 76944 109793741
Cutaneous lupus erythematosus 24.07 9.81 63 718551 3425 109867260
Chronic kidney disease-mineral and bone disorder 24.07 9.81 25 718589 613 109870072
Body temperature decreased 24.01 9.81 141 718473 36794 109833891
Femur fracture 23.84 9.81 414 718200 44055 109826630
Haemoptysis 23.83 9.81 620 717994 70734 109799951
Tachycardia 23.79 9.81 1745 716869 224900 109645785
Superinfection 23.79 9.81 87 718527 5676 109865009
Ear pain 23.71 9.81 226 718388 53000 109817685
Miosis 23.64 9.81 69 718545 21914 109848771
Red blood cell sedimentation rate 23.61 9.81 3 718611 5211 109865474
Facial paralysis 23.57 9.81 251 718363 23963 109846722
Blood creatinine increased 23.45 9.81 1432 717182 181457 109689228
Infective exacerbation of chronic obstructive airways disease 23.45 9.81 59 718555 3131 109867554
Acute interstitial pneumonitis 23.11 9.81 37 718577 1409 109869276
Small intestinal obstruction 23.07 9.81 315 718299 31898 109838787
Bronchopulmonary aspergillosis allergic 23.06 9.81 13 718601 8413 109862272
Incontinence 23.05 9.81 186 718428 16449 109854236
Muscle spasms 23.00 9.81 2103 716511 276054 109594631
Pulmonary vasculitis 22.98 9.81 7 718607 6553 109864132
Multiple drug therapy 22.86 9.81 108 718506 7906 109862779
Lupus-like syndrome 22.82 9.81 163 718451 40629 109830056
Pulmonary hypertension 22.77 9.81 494 718120 54726 109815959
Chronic spontaneous urticaria 22.77 9.81 44 718570 1949 109868736
Poor sucking reflex 22.75 9.81 13 718601 124 109870561
Eye irritation 22.70 9.81 324 718290 33128 109837557
Cystic fibrosis 22.63 9.81 75 718539 4656 109866029
Steroid dependence 22.62 9.81 112 718502 8357 109862328
Product label on wrong product 22.52 9.81 10 718604 52 109870633
Photopsia 22.52 9.81 90 718524 6124 109864561
Respiratory arrest 22.51 9.81 256 718358 58043 109812642
Anal incontinence 22.48 9.81 230 718384 21734 109848951
Discoloured vomit 22.40 9.81 44 718570 1973 109868712
Nephrosclerosis 22.33 9.81 44 718570 1977 109868708
Breast cancer stage I 22.32 9.81 10 718604 7377 109863308
Lipase increased 22.30 9.81 202 718412 18470 109852215
Acquired oesophageal web 22.30 9.81 18 718596 315 109870370
Drug effective for unapproved indication 22.26 9.81 36 718578 14131 109856554
Choluria 22.17 9.81 21 718593 459 109870226
Respiratory tract infection 22.12 9.81 616 717998 71001 109799684
Respiratory tract malformation 22.06 9.81 12 718602 103 109870582
Vascular encephalopathy 22.04 9.81 27 718587 797 109869888
Immunosuppressant drug level increased 21.99 9.81 141 718473 11583 109859102
Myoclonic dystonia 21.98 9.81 11 718603 78 109870607
Nervousness 21.93 9.81 349 718265 36502 109834183
Oesophageal perforation 21.93 9.81 39 718575 1620 109869065
Hypergammaglobulinaemia 21.85 9.81 29 718585 929 109869756
Adjusted calcium decreased 21.83 9.81 16 718598 241 109870444
Nephropathy 21.70 9.81 156 718458 13311 109857374
Gastrointestinal sounds abnormal 21.68 9.81 87 718527 5931 109864754
Arrhythmia 21.65 9.81 599 718015 68976 109801709
Renal impairment 21.53 9.81 1461 717153 186984 109683701
Pharyngeal swelling 21.53 9.81 143 718471 11889 109858796
Soft tissue mass 21.51 9.81 37 718577 1496 109869189
Vasculitis 21.45 9.81 340 718274 35533 109835152
Pneumocystis jirovecii pneumonia 21.44 9.81 176 718438 42559 109828126
Moraxella test positive 21.41 9.81 8 718606 24 109870661
Skin necrosis 21.38 9.81 70 718544 21442 109849243
Blood test abnormal 21.34 9.81 104 718510 28450 109842235
Hypergastrinaemia 21.24 9.81 18 718596 338 109870347
Substance abuse 21.20 9.81 30 718584 12433 109858252
Anxiety 21.18 9.81 2557 716057 342521 109528164
Epstein-Barr virus associated lymphoproliferative disorder 21.18 9.81 3 718611 4799 109865886
Product blister packaging issue 21.16 9.81 18 718596 340 109870345
Product residue present 21.15 9.81 65 718549 3876 109866809
Oropharyngeal blistering 21.14 9.81 28 718586 895 109869790
General symptom 21.02 9.81 16 718598 8830 109861855
Drug reaction with eosinophilia and systemic symptoms 21.02 9.81 690 717924 81405 109789280
Caesarean section 20.89 9.81 36 718578 13781 109856904
Pneumatosis intestinalis 20.82 9.81 15 718599 8514 109862171
Myasthenia gravis 20.69 9.81 71 718543 21440 109849245
Product dispensing error 20.65 9.81 179 718435 16166 109854519
Full blood count decreased 20.64 9.81 308 718306 31791 109838894
Urinary tract infection pseudomonal 20.59 9.81 45 718569 2177 109868508
Coronary artery occlusion 20.59 9.81 174 718440 15598 109855087
Oral discomfort 20.58 9.81 135 718479 11176 109859509
Degenerative mitral valve disease 20.57 9.81 17 718597 308 109870377
Cyanosis 20.56 9.81 289 718325 29452 109841233
Platelet count decreased 20.55 9.81 1752 716862 228691 109641994
Epigastric discomfort 20.48 9.81 114 718500 8901 109861784
Malignant spinal cord compression 20.44 9.81 13 718601 153 109870532
Aminoaciduria 20.39 9.81 18 718596 358 109870327
Impaired gastric emptying 20.37 9.81 152 718462 13123 109857562
Accidental death 20.16 9.81 4 718610 5005 109865680
Pain 20.07 9.81 5715 712899 949240 108921445
Ectopic gastric mucosa 20.07 9.81 8 718606 30 109870655
Ulcer haemorrhage 20.06 9.81 77 718537 22494 109848191
Haematotoxicity 20.00 9.81 70 718544 21012 109849673
Abnormal dreams 19.99 9.81 147 718467 12633 109858052
Osteoporosis 19.91 9.81 423 718191 86729 109783956
Total lung capacity abnormal 19.90 9.81 3 718611 4580 109866105
Diffuse large B-cell lymphoma recurrent 19.87 9.81 8 718606 6291 109864394
Irritability 19.81 9.81 428 718186 47381 109823304
Intestinal dilatation 19.71 9.81 60 718554 3560 109867125
Renal cell carcinoma 19.70 9.81 99 718515 7431 109863254
Febrile neutropenia 19.64 9.81 1781 716833 314986 109555699
Atrioventricular block second degree 19.63 9.81 105 718509 8076 109862609
Blood bilirubin increased 19.57 9.81 639 717975 75333 109795352
Epiploic appendagitis 19.48 9.81 13 718601 167 109870518
Oesophageal atresia 19.42 9.81 11 718603 103 109870582
Metabolic acidosis 19.40 9.81 813 717801 98931 109771754
Pancreatitis necrotising 19.40 9.81 79 718535 5422 109865263
Hallucination, visual 19.22 9.81 363 718251 39242 109831443
Therapeutic response shortened 19.20 9.81 113 718501 29470 109841215
International normalised ratio abnormal 19.11 9.81 87 718527 6270 109864415
Subdural haematoma 19.04 9.81 338 718276 36116 109834569
Intestinal ulcer 19.01 9.81 46 718568 2381 109868304
Mite allergy 18.92 9.81 7 718607 5796 109864889
Hypocholesterolaemia 18.92 9.81 9 718605 6412 109864273
Rhinitis 18.91 9.81 227 718387 22318 109848367
Eructation 18.84 9.81 156 718458 13901 109856784
Thermohypoaesthesia 18.72 9.81 11 718603 111 109870574
Breath sounds abnormal 18.72 9.81 93 718521 25311 109845374
Large intestine infection 18.70 9.81 68 718546 4424 109866261
Hepatic haematoma 18.69 9.81 27 718587 938 109869747
Agitated depression 18.64 9.81 21 718593 566 109870119
Genital pain 18.62 9.81 33 718581 1367 109869318
Product taste abnormal 18.55 9.81 47 718567 2505 109868180
Indifference 18.54 9.81 17 718597 356 109870329
Drug withdrawal syndrome 18.54 9.81 349 718265 37705 109832980
Aphonia 18.48 9.81 145 718469 12715 109857970
Amylase increased 18.46 9.81 142 718472 12377 109858308
Petechiae 18.36 9.81 232 718382 23085 109847600
Prothrombin level decreased 18.33 9.81 38 718576 1772 109868913
Abnormal behaviour 18.32 9.81 356 718258 38683 109832002
Intestinal obstruction 18.21 9.81 464 718150 52763 109817922
Abnormal weight gain 18.15 9.81 58 718556 3533 109867152
Helicobacter test positive 18.13 9.81 32 718582 1321 109869364
Suicidal ideation 18.12 9.81 765 717849 93172 109777513
Oedema mouth 18.10 9.81 53 718561 3077 109867608
Nasal oedema 18.08 9.81 11 718603 6828 109863857
Adrenal insufficiency 18.04 9.81 182 718432 42208 109828477
Ventilation perfusion mismatch 17.98 9.81 24 718590 773 109869912
Hypomania 17.94 9.81 24 718590 10186 109860499
Product packaging confusion 17.93 9.81 17 718597 372 109870313
Sarcoidosis 17.92 9.81 34 718580 12545 109858140
Acute psychosis 17.89 9.81 72 718542 4915 109865770
Haemorrhage intracranial 17.87 9.81 276 718338 28693 109841992
Yellow skin 17.85 9.81 63 718551 4039 109866646
Pseudoporphyria 17.84 9.81 24 718590 779 109869906
Subileus 17.82 9.81 86 718528 6351 109864334
Hypervolaemia 17.77 9.81 434 718180 49026 109821659
Ventricular dysfunction 17.75 9.81 96 718518 7415 109863270
Bleeding time prolonged 17.72 9.81 31 718583 1271 109869414
Ischaemic stroke 17.61 9.81 371 718243 40892 109829793
Mental status changes 17.53 9.81 632 717982 75490 109795195
Faecal calprotectin increased 17.50 9.81 11 718603 6708 109863977
Musculoskeletal chest pain 17.47 9.81 274 718340 28573 109842112
Gamma-glutamyltransferase increased 17.46 9.81 522 718092 60787 109809898
Erectile dysfunction 17.44 9.81 191 718423 18365 109852320
Hot flush 17.42 9.81 557 718057 65479 109805206
Endoscopy abnormal 17.37 9.81 8 718606 46 109870639
Spirometry abnormal 17.31 9.81 7 718607 5490 109865195
Polyarthritis 17.30 9.81 64 718550 18899 109851786
Dactylitis 17.28 9.81 3 718611 4130 109866555
Nocardiosis 17.21 9.81 14 718600 7472 109863213
Reaction to excipient 17.19 9.81 40 718574 2019 109868666
Retching 17.15 9.81 224 718390 22458 109848227
Cerebral haemorrhage 17.14 9.81 548 718066 64420 109806265
Electrocardiogram QRS complex prolonged 17.01 9.81 37 718577 12984 109857701
Radiation inflammation 17.00 9.81 27 718587 1021 109869664
Subdural haemorrhage 17.00 9.81 86 718528 6472 109864213
Haemorrhoids 16.98 9.81 326 718288 35346 109835339
Fear of eating 16.95 9.81 19 718595 509 109870176
Cerebral haematoma 16.95 9.81 114 718500 9518 109861167
Speech disorder 16.95 9.81 522 718092 61047 109809638
Administration related reaction 16.92 9.81 15 718599 300 109870385
Torus fracture 16.91 9.81 11 718603 135 109870550
Calcium metabolism disorder 16.87 9.81 9 718605 74 109870611
Vasculitic rash 16.86 9.81 42 718572 2215 109868470
Acidosis 16.83 9.81 222 718392 22309 109848376
Cytomegalovirus chorioretinitis 16.80 9.81 13 718601 7115 109863570
Viral diarrhoea 16.76 9.81 20 718594 574 109870111
Haematoma 16.69 9.81 498 718116 57978 109812707
Ventricular flutter 16.69 9.81 10 718604 105 109870580
Vertigo positional 16.63 9.81 60 718554 3888 109866797
Oesophageal adenocarcinoma 16.57 9.81 26 718588 973 109869712
Achlorhydria 16.57 9.81 6 718608 16 109870669
Febrile bone marrow aplasia 16.56 9.81 58 718556 17407 109853278
Hyperreflexia 16.53 9.81 112 718502 9373 109861312
Gastritis erosive 16.53 9.81 134 718480 11866 109858819
Hyponatraemic syndrome 16.47 9.81 23 718591 774 109869911
Blood electrolytes decreased 16.46 9.81 36 718578 1743 109868942
Colorectal cancer 16.45 9.81 21 718593 9093 109861592
Exposure to toxic agent 16.42 9.81 37 718577 12821 109857864
Dermatitis exfoliative 16.34 9.81 128 718486 11219 109859466
Nephroangiosclerosis 16.26 9.81 17 718597 420 109870265
Avian influenza 16.22 9.81 10 718604 111 109870574
Blood pressure diastolic increased 16.17 9.81 65 718549 18742 109851943
Mesenteric artery thrombosis 16.08 9.81 25 718589 928 109869757
Drug dispensed to wrong patient 16.06 9.81 22 718592 727 109869958
Oropharyngeal pain 16.02 9.81 1052 717562 134224 109736461
Alanine aminotransferase increased 15.89 9.81 1394 717220 182379 109688306
Mesenteric vein thrombosis 15.83 9.81 38 718576 1957 109868728
Muscle contractions involuntary 15.81 9.81 64 718550 4380 109866305
Blood cholesterol decreased 15.72 9.81 46 718568 2670 109868015
Abdominal sepsis 15.71 9.81 42 718572 2313 109868372
Endophthalmitis 15.69 9.81 18 718596 8169 109862516
Faecaloma 15.68 9.81 157 718457 14751 109855934
Atrial flutter 15.68 9.81 233 718381 24029 109846656
Blood copper increased 15.67 9.81 7 718607 37 109870648
Hepatic failure 15.66 9.81 570 718044 68169 109802516
Gastric antral vascular ectasia 15.64 9.81 28 718586 1169 109869516
Hepatitis toxic 15.60 9.81 78 718536 5843 109864842
Feeling drunk 15.60 9.81 74 718540 5426 109865259
Diverticulitis 15.60 9.81 457 718157 53065 109817620
Hepatomegaly 15.58 9.81 210 718404 21204 109849481
Menstrual disorder 15.54 9.81 67 718547 4717 109865968
Drop attacks 15.54 9.81 27 718587 1101 109869584
Respiratory depression 15.51 9.81 133 718481 31868 109838817
Gallbladder adenocarcinoma 15.49 9.81 10 718604 121 109870564
Renal pain 15.40 9.81 113 718501 9704 109860981
Intermittent claudication 15.38 9.81 56 718558 3645 109867040
Skin test positive 15.36 9.81 31 718583 1418 109869267
Drug dose titration not performed 15.34 9.81 26 718588 1039 109869646
Metastatic renal cell carcinoma 15.32 9.81 43 718571 2437 109868248
Dermatomyositis 15.32 9.81 63 718551 4343 109866342
Use of accessory respiratory muscles 15.30 9.81 21 718593 695 109869990
Duodenal ulcer 15.30 9.81 194 718420 19320 109851365
Occupational exposure to air contaminants 15.27 9.81 11 718603 161 109870524
Leukocytosis 15.25 9.81 458 718156 53370 109817315
Granuloma annulare 15.23 9.81 23 718591 832 109869853
Portal vein thrombosis 15.21 9.81 88 718526 6970 109863715
Gastrointestinal erosion 15.19 9.81 27 718587 1121 109869564
Bladder disorder 15.15 9.81 124 718490 11013 109859672
Immune-mediated hepatic disorder 15.14 9.81 5 718609 4445 109866240
Non-small cell lung cancer stage III 15.12 9.81 5 718609 9 109870676
Bladder cancer 15.11 9.81 74 718540 20218 109850467
Arthritis 15.08 9.81 913 717701 166673 109704012
Gastric ulcer 15.07 9.81 352 718262 39475 109831210
Inappropriate schedule of product administration 15.04 9.81 1129 717485 202508 109668177
Haematocrit decreased 15.00 9.81 548 718066 65569 109805116
Erosive oesophagitis 14.99 9.81 49 718565 3020 109867665
Viral mutation identified 14.98 9.81 5 718609 4414 109866271
Bronchopulmonary aspergillosis 14.97 9.81 123 718491 29740 109840945
Therapeutic product ineffective 14.97 9.81 44 718570 2560 109868125
Intestinal ischaemia 14.96 9.81 166 718448 16013 109854672
Urine output decreased 14.91 9.81 196 718418 19680 109851005
Atrophic vulvovaginitis 14.89 9.81 30 718584 1370 109869315
Choking 14.88 9.81 157 718457 14953 109855732
Initial insomnia 14.85 9.81 117 718497 10272 109860413
Peripheral circulatory failure 14.82 9.81 35 718579 1784 109868901
Pneumonia streptococcal 14.68 9.81 53 718561 3436 109867249
Blood immunoglobulin E increased 14.66 9.81 91 718523 7391 109863294
Erythrodermic psoriasis 14.59 9.81 37 718577 1973 109868712
Altered state of consciousness 14.57 9.81 275 718339 57351 109813334
Ceruloplasmin increased 14.57 9.81 6 718608 25 109870660
Bradypnoea 14.53 9.81 21 718593 8628 109862057
Depressed mood 14.53 9.81 507 718107 60302 109810383
Coronary artery stenosis 14.53 9.81 145 718469 13613 109857072
Dyspnoea exertional 14.52 9.81 821 717793 103239 109767446
Surgery 14.46 9.81 361 718253 40922 109829763
Bradycardia 14.44 9.81 1186 717428 154331 109716354
Xeroderma 14.43 9.81 19 718595 604 109870081
Aphasia 14.37 9.81 493 718121 58504 109812181
Atypical femur fracture 14.37 9.81 79 718535 6140 109864545
Retroperitoneal fibrosis 14.34 9.81 21 718593 739 109869946
Anal haemorrhage 14.32 9.81 67 718547 4885 109865800
Nephritis 14.28 9.81 78 718536 6048 109864637
Stoma site haemorrhage 14.25 9.81 41 718573 2357 109868328
Sensory loss 14.23 9.81 207 718407 21250 109849435
Amino acid level increased 14.20 9.81 22 718592 814 109869871
Appendicitis perforated 14.13 9.81 54 718560 3598 109867087
Endocrine ophthalmopathy 14.11 9.81 29 718585 1344 109869341
Pancreatic carcinoma metastatic 14.05 9.81 59 718555 4105 109866580
Platelet count increased 14.05 9.81 245 718369 26089 109844596
Derailment 14.03 9.81 8 718606 76 109870609
Carcinoid tumour of the gastrointestinal tract 14.02 9.81 10 718604 144 109870541
Aspergillus infection 14.02 9.81 103 718511 25513 109845172
Renal cyst 13.97 9.81 180 718434 17992 109852693
Hand-eye coordination impaired 13.94 9.81 7 718607 50 109870635
Increased tendency to bruise 13.94 9.81 127 718487 11631 109859054
Maternal exposure before pregnancy 13.90 9.81 16 718598 7249 109863436
Gastric xanthoma 13.89 9.81 5 718609 13 109870672
Regurgitation 13.87 9.81 52 718562 3433 109867252
Hyperglycaemia 13.82 9.81 681 717933 84409 109786276
Accidental exposure to product 13.80 9.81 235 718379 49773 109820912
Hepatitis B reactivation 13.76 9.81 17 718597 7467 109863218
Lactation disorder 13.76 9.81 13 718601 283 109870402
Eyelid retraction 13.76 9.81 8 718606 79 109870606
COVID-19 treatment 13.75 9.81 16 718598 447 109870238
Dry throat 13.74 9.81 105 718509 9133 109861552
Cholecystitis acute 13.72 9.81 160 718454 15622 109855063
Spinal fracture 13.72 9.81 215 718399 22418 109848267
Gallbladder hypofunction 13.69 9.81 17 718597 509 109870176
Weight fluctuation 13.63 9.81 86 718528 22059 109848626
Bromhidrosis 13.63 9.81 5 718609 14 109870671
Weight decreased 13.61 9.81 3333 715281 464724 109405961
Serotonin syndrome 13.59 9.81 491 718123 58662 109812023
Limb operation 13.57 9.81 57 718557 3967 109866718
Orthopnoea 13.56 9.81 120 718494 10901 109859784
Conjunctivitis allergic 13.55 9.81 15 718599 6916 109863769
Urine calcium decreased 13.54 9.81 6 718608 31 109870654
Creatinine renal clearance increased 13.54 9.81 53 718561 3572 109867113
Polyomavirus viraemia 13.52 9.81 3 718611 3471 109867214
Nodule 13.51 9.81 141 718473 32490 109838195
Inadequate analgesia 13.46 9.81 67 718547 5010 109865675
Colitis ulcerative 13.46 9.81 391 718223 76972 109793713
Rash pustular 13.44 9.81 135 718479 12694 109857991
Fatigue 13.44 9.81 8364 710250 1207594 108663091
Multiple endocrine neoplasia Type 1 13.42 9.81 4 718610 4 109870681
Oesophageal mucosa erythema 13.42 9.81 4 718610 4 109870681
Latent tetany 13.42 9.81 4 718610 4 109870681
Intraductal papillary breast neoplasm 13.42 9.81 4 718610 4 109870681
Multiple organ dysfunction syndrome 13.38 9.81 828 717786 150882 109719803
Dyskinesia 13.32 9.81 433 718181 51013 109819672
Hypoosmolar state 13.32 9.81 15 718599 404 109870281
White blood cell count increased 13.31 9.81 763 717851 96079 109774606
Head injury 13.28 9.81 370 718244 42647 109828038
Gastrointestinal polyp 13.28 9.81 11 718603 200 109870485
Essential tremor 13.28 9.81 34 718580 1824 109868861
Blood potassium increased 13.25 9.81 296 718318 32953 109837732
Dyspnoea paroxysmal nocturnal 13.18 9.81 41 718573 2461 109868224
Goitre 13.14 9.81 77 718537 6127 109864558
Adrenal neoplasm 13.14 9.81 17 718597 531 109870154
Spinal osteoarthritis 13.11 9.81 194 718420 19989 109850696
Gastrointestinal mucosal exfoliation 13.10 9.81 12 718602 251 109870434
Glossitis 13.09 9.81 61 718553 4440 109866245
Pancytopenia 13.09 9.81 1555 717059 208058 109662627
Pulmonary alveolar haemorrhage 13.06 9.81 77 718537 20073 109850612
Blood phosphorus decreased 13.06 9.81 90 718524 7575 109863110
Pallor 13.05 9.81 469 718145 55998 109814687
Neuroglycopenia 13.04 9.81 25 718589 1101 109869584
Sudden death 13.03 9.81 227 718387 24168 109846517
Ecchymosis 13.02 9.81 171 718443 17167 109853518
Metastases to lung 12.98 9.81 92 718522 22971 109847714
Sweat discolouration 12.95 9.81 6 718608 35 109870650
Postictal paralysis 12.95 9.81 18 718596 603 109870082
Thinking abnormal 12.95 9.81 153 718461 14987 109855698
Stress 12.92 9.81 556 718058 104792 109765893
Red blood cell analysis abnormal 12.92 9.81 5 718609 17 109870668
Failure to thrive 12.88 9.81 140 718474 13434 109857251
Progressive multifocal leukoencephalopathy 12.88 9.81 102 718512 24854 109845831
Dysphonia 12.82 9.81 610 718004 75319 109795366
Prevertebral soft tissue swelling of cervical space 12.82 9.81 6 718608 36 109870649
Cardiac failure 12.81 9.81 1400 717214 186226 109684459
Blood loss anaemia 12.80 9.81 176 718438 17849 109852836
Venoocclusive liver disease 12.80 9.81 53 718561 15154 109855531
Rotator cuff syndrome 12.76 9.81 166 718448 16628 109854057
Supraventricular extrasystoles 12.71 9.81 93 718521 7980 109862705
Sight disability 12.70 9.81 11 718603 213 109870472
Laryngeal oedema 12.70 9.81 108 718506 9699 109860986
Acute coronary syndrome 12.69 9.81 216 718398 22896 109847789
DNA antibody 12.68 9.81 6 718608 37 109870648
Delusional disorder, persecutory type 12.66 9.81 18 718596 616 109870069
Diverticulum intestinal 12.61 9.81 124 718490 11595 109859090
Portal fibrosis 12.61 9.81 19 718595 686 109869999
Personality disorder 12.60 9.81 42 718572 12795 109857890
Hypocalcaemic seizure 12.59 9.81 9 718605 130 109870555
Lung adenocarcinoma stage IV 12.59 9.81 17 718597 554 109870131
Food aversion 12.57 9.81 31 718583 1624 109869061
Mood altered 12.56 9.81 202 718412 21173 109849512
Formication 12.55 9.81 71 718543 5577 109865108
Malnutrition 12.55 9.81 248 718366 27031 109843654
Diverticular fistula 12.55 9.81 4 718610 6 109870679
Alcoholic liver disease 12.54 9.81 17 718597 556 109870129
Lymphangitis 12.54 9.81 30 718584 1542 109869143
Tracheo-oesophageal fistula 12.53 9.81 19 718595 690 109869995
Cytopenia 12.53 9.81 130 718484 29986 109840699
Nephrolithiasis 12.50 9.81 538 718076 65674 109805011
Eye swelling 12.48 9.81 292 718322 32756 109837929
Product monitoring error 12.47 9.81 100 718514 8827 109861858
Mineral deficiency 12.45 9.81 8 718606 96 109870589
Incoherent 12.43 9.81 95 718519 8263 109862422
Hepatitis acute 12.43 9.81 181 718433 18585 109852100
Magnesium deficiency 12.43 9.81 20 718594 765 109869920
Gastrointestinal polyp haemorrhage 12.43 9.81 20 718594 765 109869920
Antipsychotic drug level decreased 12.42 9.81 28 718586 1384 109869301
Fibrinolysis 12.41 9.81 7 718607 65 109870620
Product odour abnormal 12.40 9.81 30 718584 1553 109869132
Hyperventilation 12.37 9.81 100 718514 8847 109861838
Spondylolysis 12.33 9.81 11 718603 222 109870463
Visceral pain 12.31 9.81 9 718605 135 109870550
Pregnancy with contraceptive device 12.26 9.81 5 718609 3902 109866783
Ventricular enlargement 12.23 9.81 19 718595 705 109869980
Varicella zoster virus infection 12.21 9.81 14 718600 6354 109864331
Hair injury 12.17 9.81 6 718608 41 109870644
Aspiration pleural cavity abnormal 12.13 9.81 3 718611 0 109870685
Hepatic fibrosis marker increased 12.13 9.81 3 718611 0 109870685
Anal chlamydia infection 12.13 9.81 3 718611 0 109870685
Nephrostomy tube removal 12.13 9.81 3 718611 0 109870685
Vertigo labyrinthine 12.13 9.81 3 718611 0 109870685
Apathy 12.13 9.81 160 718454 16079 109854606
Urine chloride decreased 12.10 9.81 8 718606 101 109870584
Alveolitis 12.07 9.81 59 718555 4380 109866305
Blood uric acid increased 12.06 9.81 86 718528 21443 109849242
Sepsis neonatal 12.04 9.81 8 718606 102 109870583
Borderline personality disorder 12.04 9.81 24 718590 1088 109869597
Therapy cessation 12.00 9.81 379 718235 44478 109826207
Thrombosis 11.98 9.81 840 717774 107822 109762863
Target skin lesion 11.96 9.81 12 718602 282 109870403
Sensitisation 11.96 9.81 6 718608 4145 109866540
Hepatic rupture 11.93 9.81 9 718605 142 109870543
Vulvovaginal ulceration 11.93 9.81 5 718609 22 109870663
Cardiac flutter 11.90 9.81 71 718543 5686 109864999
Hyperbilirubinaemia 11.89 9.81 272 718342 30399 109840286
Paranoia 11.88 9.81 208 718406 22166 109848519
Lichen nitidus 11.87 9.81 9 718605 143 109870542
Respiratory failure 11.84 9.81 1585 717029 213747 109656938
Lung consolidation 11.84 9.81 112 718502 10364 109860321
Adenocarcinoma gastric 11.83 9.81 35 718579 2044 109868641
Feeling jittery 11.82 9.81 147 718467 14575 109856110
Alanine aminotransferase abnormal 11.80 9.81 27 718587 9307 109861378
Psychiatric decompensation 11.80 9.81 12 718602 5753 109864932
Protein total abnormal 11.76 9.81 19 718595 729 109869956
Sickle cell anaemia with crisis 11.76 9.81 28 718586 9517 109861168
Non-small cell lung cancer stage IV 11.74 9.81 11 718603 237 109870448
Second primary malignancy 11.73 9.81 69 718545 17999 109852686
Cleft palate 11.73 9.81 14 718600 402 109870283
Foetal exposure timing unspecified 11.72 9.81 7 718607 73 109870612
Pollakiuria 11.71 9.81 373 718241 43822 109826863
Nocturia 11.70 9.81 165 718449 16825 109853860
Diabetic ketoacidosis 11.69 9.81 357 718257 41701 109828984
Heart rate increased 11.66 9.81 1086 717528 142748 109727937
Duodenal obstruction 11.65 9.81 15 718599 466 109870219
Bipolar I disorder 11.65 9.81 37 718577 2246 109868439
Campylobacter infection 11.64 9.81 38 718576 2341 109868344
Calciphylaxis 11.63 9.81 56 718558 4131 109866554
Epstein-Barr virus infection reactivation 11.62 9.81 6 718608 4078 109866607
Biliary tract disorder 11.61 9.81 32 718582 1794 109868891
Osteitis 11.61 9.81 57 718557 4239 109866446
Graft versus host disease 11.59 9.81 73 718541 18733 109851952
Necrotising panniculitis 11.56 9.81 7 718607 75 109870610
Unresponsive to stimuli 11.53 9.81 516 718098 63274 109807411
Magnesium metabolism disorder 11.49 9.81 6 718608 47 109870638
Radiotherapy to brain 11.49 9.81 6 718608 47 109870638
Clostridium difficile colitis 11.48 9.81 369 718245 43409 109827276
Posterior reversible encephalopathy syndrome 11.44 9.81 153 718461 33708 109836977
Urine flow decreased 11.39 9.81 27 718587 1379 109869306
Facial bones fracture 11.39 9.81 63 718551 4908 109865777
International normalised ratio decreased 11.36 9.81 92 718522 8144 109862541
Hyperosmolar state 11.36 9.81 19 718595 751 109869934
Foreign body 11.36 9.81 44 718570 2951 109867734
Hypogammaglobulinaemia 11.34 9.81 80 718534 19996 109850689
Acute myeloid leukaemia recurrent 11.34 9.81 10 718604 5129 109865556
Nephritis allergic 11.34 9.81 23 718591 1056 109869629
Intestinal metaplasia 11.33 9.81 7 718607 78 109870607
Carotid artery disease 11.32 9.81 36 718578 2187 109868498
Neuroendocrine tumour 11.30 9.81 29 718585 1558 109869127
Anaemia folate deficiency 11.29 9.81 18 718596 683 109870002
Thoracic vertebral fracture 11.25 9.81 78 718536 6577 109864108
Acute sinusitis 11.25 9.81 65 718549 5146 109865539
Plicated tongue 11.22 9.81 9 718605 156 109870529
Pelvic fracture 11.22 9.81 141 718473 14013 109856672
Hepatitis B 11.21 9.81 29 718585 9583 109861102
Device dislocation 11.18 9.81 142 718472 31562 109839123
Somatosensory evoked potentials abnormal 11.16 9.81 10 718604 203 109870482
Nail bed bleeding 11.16 9.81 20 718594 836 109869849
Gastrointestinal obstruction 11.16 9.81 36 718578 2204 109868481
Bradyphrenia 11.15 9.81 121 718493 11607 109859078
Kidney small 11.12 9.81 11 718603 254 109870431
Gastrointestinal pain 11.11 9.81 122 718492 11738 109858947
Gastric dysplasia 11.11 9.81 5 718609 27 109870658
Intentional product misuse 11.10 9.81 729 717885 132175 109738510
Blood chloride decreased 11.09 9.81 99 718515 9016 109861669
Blood magnesium abnormal 11.09 9.81 19 718595 766 109869919
Toxic shock syndrome 11.05 9.81 28 718586 1492 109869193
Penile oedema 11.05 9.81 12 718602 310 109870375
Renal hypertension 11.05 9.81 11 718603 256 109870429
Rebound effect 11.02 9.81 54 718560 14752 109855933
Illness 11.02 9.81 646 717968 81525 109789160
Diverticular perforation 11.02 9.81 75 718539 6287 109864398
Polycystic ovaries 10.99 9.81 9 718605 4787 109865898
Androgenetic alopecia 10.98 9.81 11 718603 258 109870427
Primary hypoparathyroidism 10.98 9.81 6 718608 52 109870633
Urosepsis 10.97 9.81 269 718345 30406 109840279
Depression 10.96 9.81 2278 716336 315057 109555628
Drug eruption 10.96 9.81 265 718349 53394 109817291
Tooth loss 10.93 9.81 90 718524 8006 109862679
Exposure via breast milk 10.90 9.81 22 718592 1006 109869679
Faeces pale 10.89 9.81 47 718567 3310 109867375
Oesophageal varices haemorrhage 10.88 9.81 62 718552 4883 109865802
Listless 10.87 9.81 58 718556 4457 109866228
Thrombotic microangiopathy 10.86 9.81 129 718485 29020 109841665
Allergy to chemicals 10.86 9.81 4 718610 3321 109867364
Breast pain 10.85 9.81 106 718508 9894 109860791
Supine hypertension 10.83 9.81 14 718600 437 109870248
Sinonasal obstruction 10.82 9.81 13 718601 376 109870309
Food intolerance 10.79 9.81 58 718556 4469 109866216
Gastrinoma 10.79 9.81 6 718608 54 109870631
Biliary cyst 10.78 9.81 8 718606 123 109870562
Superior mesenteric artery syndrome 10.77 9.81 10 718604 213 109870472
Gastroenteritis eosinophilic 10.76 9.81 13 718601 378 109870307
Urticaria vesiculosa 10.70 9.81 4 718610 12 109870673
Vitamin D decreased 10.69 9.81 124 718490 12091 109858594
Feeling cold 10.68 9.81 293 718321 33694 109836991
Vulvar basal cell carcinoma 10.68 9.81 5 718609 30 109870655
Generalised anxiety disorder 10.68 9.81 41 718573 2738 109867947
Hypoacusis 10.67 9.81 302 718312 34889 109835796
Cystic fibrosis lung 10.67 9.81 9 718605 168 109870517
Transplant rejection 10.65 9.81 105 718509 24462 109846223
Paraneoplastic rash 10.62 9.81 7 718607 88 109870597
Respirovirus test positive 10.61 9.81 8 718606 126 109870559
Paternal exposure during pregnancy 10.61 9.81 10 718604 217 109870468
Poliomyelitis 10.61 9.81 6 718608 56 109870629
Eosinophilic fasciitis 10.60 9.81 13 718601 384 109870301
Transplant dysfunction 10.60 9.81 24 718590 8304 109862381
Seborrhoeic keratosis 10.60 9.81 45 718569 3147 109867538
Cardiomegaly 10.58 9.81 256 718358 28874 109841811
Oropharyngeal swelling 10.56 9.81 27 718587 1447 109869238
Parotid gland haemorrhage 10.55 9.81 5 718609 31 109870654
Acquired cystic kidney disease 10.52 9.81 6 718608 57 109870628
Alkalosis hypochloraemic 10.47 9.81 16 718598 585 109870100
Infantile spitting up 10.47 9.81 4 718610 13 109870672
Radiculopathy 10.46 9.81 78 718536 19258 109851427
Blast cells present 10.46 9.81 21 718593 957 109869728
Peptic ulcer 10.45 9.81 85 718529 7534 109863151
Osteochondritis 10.41 9.81 5 718609 32 109870653
Hypersensitivity vasculitis 10.40 9.81 79 718535 6858 109863827
Salivary gland enlargement 10.39 9.81 14 718600 455 109870230
Renal mass 10.38 9.81 49 718565 3586 109867099
Glomerular filtration rate decreased 10.38 9.81 254 718360 28702 109841983
Food poisoning 10.37 9.81 74 718540 6298 109864387
Salmonellosis 10.35 9.81 35 718579 2196 109868489
Pulmonary function test decreased 10.33 9.81 94 718520 8606 109862079
Gastric disorder 10.32 9.81 287 718327 33070 109837615
Hypersomnia 10.31 9.81 247 718367 27814 109842871
Jealous delusion 10.30 9.81 14 718600 459 109870226
Intracranial haemangioma 10.29 9.81 5 718609 33 109870652
Pulmonary vascular disorder 10.28 9.81 22 718592 1049 109869636
Pseudomembranous colitis 10.28 9.81 74 718540 6317 109864368
Blindness unilateral 10.27 9.81 103 718511 9683 109861002
Alcohol use disorder 10.26 9.81 6 718608 60 109870625
X-ray of pelvis and hip abnormal 10.25 9.81 4 718610 14 109870671
Splenic calcification 10.25 9.81 4 718610 14 109870671
Head discomfort 10.22 9.81 177 718437 18823 109851862
Tongue discolouration 10.22 9.81 53 718561 4028 109866657
Anaphylactic reaction 10.18 9.81 869 717745 113431 109757254
Renal atrophy 10.18 9.81 36 718578 2310 109868375
Blood phosphorus abnormal 10.18 9.81 12 718602 340 109870345
Plethoric face 10.16 9.81 5 718609 34 109870651
Hepatobiliary infection 10.16 9.81 5 718609 34 109870651
Oedema peripheral 10.16 9.81 2347 716267 326313 109544372
Stress fracture 10.15 9.81 81 718533 7140 109863545
Genital rash 10.14 9.81 25 718589 1310 109869375
Cytomegalovirus colitis 10.13 9.81 19 718595 7042 109863643
Migraine 10.07 9.81 969 717645 170683 109700002
Biliary neoplasm 10.07 9.81 3 718611 3 109870682
Genital prolapse 10.07 9.81 3 718611 3 109870682
Stertor 10.07 9.81 3 718611 3 109870682
Oesophageal candidiasis 10.06 9.81 117 718497 11417 109859268
Intra-abdominal haematoma 10.06 9.81 47 718567 3425 109867260
Oral administration complication 10.05 9.81 8 718606 137 109870548
Dermatitis bullous 10.05 9.81 165 718449 17364 109853321
Lung infiltration 10.05 9.81 220 718394 24408 109846277
Intestinal fistula infection 10.04 9.81 4 718610 15 109870670
Ventricular failure 10.03 9.81 15 718599 538 109870147
Eye infection fungal 10.00 9.81 16 718598 609 109870076
Herbal interaction 9.98 9.81 16 718598 610 109870075
Sensory disturbance 9.97 9.81 164 718450 17265 109853420
Acute graft versus host disease in skin 9.96 9.81 36 718578 10704 109859981
Myoclonus 9.96 9.81 283 718331 32715 109837970
Duodenal perforation 9.94 9.81 40 718574 2730 109867955
Neurological symptom 9.93 9.81 60 718554 15548 109855137
Brain abscess 9.92 9.81 18 718596 6756 109863929
Amyloidosis 9.91 9.81 44 718570 3137 109867548
Cerebral toxoplasmosis 9.90 9.81 4 718610 3138 109867547
Muscle rupture 9.87 9.81 56 718558 4404 109866281
Chronic hepatic failure 9.86 9.81 24 718590 1247 109869438
Lymphoproliferative disorder 9.86 9.81 20 718594 7198 109863487
Eczema eyelids 9.85 9.81 13 718601 414 109870271
Teratogenicity 9.83 9.81 10 718604 239 109870446
Laryngeal discomfort 9.83 9.81 18 718596 765 109869920

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BC01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Proton pump inhibitors
ATC A02BC51 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Proton pump inhibitors
ATC A02BD01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
ATC A02BD05 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
ATC A02BD16 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
FDA MoA N0000000147 Proton Pump Inhibitors
FDA EPC N0000175525 Proton Pump Inhibitor
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054328 Proton Pump Inhibitors
FDA MoA N0000182140 Cytochrome P450 2C19 Inhibitors
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:49200 EC 3.6.3.10 (<em>H</em><small><sup>+</small></sup>/<em>K</em><small><sup>+</small></sup>-exchanging ATPase) inhibitor
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50183 P450 inhibitor
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:64951 anti-HBV agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:233423 antifibrotic agent

Related Drugs by ATC class:

A02BC Proton pump inhibitors 8 drugs
dexlansoprazoledexrabeprazoleesomeprazoleilaprazolelansoprazolepantoprazolerabeprazolevonoprazan
A02BD Combinations for eradication of Helicobacter pylori 13 drugs
amoxicillinbismuth subcitrateclarithromycinesomeprazolelansoprazolelevofloxacinmetronidazolepantoprazolerabeprazolerifabutintetracyclinetinidazole show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Reduction of risk of upper gastrointestinal bleeding indication 37372002
Erosive esophagitis indication 40719004
Duodenal ulcer disease indication 51868009 DOID:1724
Zollinger-Ellison syndrome indication 53132006 DOID:0050782
Peptic reflux disease indication 57643001
Gastroesophageal reflux disease indication 235595009 DOID:8534
Gastric ulcer indication 397825006 DOID:10808
Duodenal Ulcer due to H. Pylori indication
Maintenance of Healing Erosive Esophagitis indication
Pathological Gastric Hypersecretory Condition indication
Gastric Hypersecretory Conditions indication
Upper gastrointestinal hemorrhage off-label use 37372002
Chronic heart failure contraindication 48447003
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Osteoporosis contraindication 64859006 DOID:11476
Oliguria contraindication 83128009
Atrophic gastritis contraindication 84568007 DOID:8929
Fracture of bone contraindication 125605004
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Edema contraindication 267038008




🐶 Veterinary Drug Use

SpeciesUseRelation
Horses Gastric ulcers Indication

🐶 Veterinary products

ProductApplicantIngredients
GastroGard Boehringer lngelheim Animal Health USA Inc. 1
UlcerGard Boehringer lngelheim Animal Health USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.71 acidic
pKa2 4.44 Basic
pKa3 2.53 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
325MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9987231 Jan. 2, 2033 FOR SECONDARY PREVENTION OF CARDIOVASCULAR AND CEREBROVASCULAR EVENTS IN PATIENTS AT RISK OF DEVELOPING ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9987231 Jan. 2, 2033 FOR SECONDARY PREVENTION OF CARDIOVASCULAR AND CEREBROVASCULAR EVENTS IN PATIENTS AT RISK OF DEVELOPING ASPIRIN-ASSOCIATED GASTRIC ULCERS
325MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9539214 March 13, 2033 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
81MG;40MG YOSPRALA GENUS LIFESCIENCES N205103 Sept. 14, 2016 DISCN TABLET, DELAYED RELEASE ORAL 9539214 March 13, 2033 TREATMENT OR SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE, CARDIOVASCULAR EVENTS, OR CEREBROVASCULAR EVENTS AND RISK-REDUCTION OF ASPIRIN-ASSOCIATED GASTRIC ULCERS
250MG;EQ 10MG BASE;12.5MG TALICIA TALICIA HOLDINGS N213004 Nov. 1, 2019 RX CAPSULE, DELAYED RELEASE ORAL 11135172 Feb. 12, 2034 TREATMENT OF H. PYLORI INFECTION IN ADULTS
250MG;EQ 10MG BASE;12.5MG TALICIA TALICIA HOLDINGS N213004 Nov. 1, 2019 RX CAPSULE, DELAYED RELEASE ORAL 11931463 Feb. 12, 2034 TREATMENT OF HELICOBACTER PYLORI INFECTION IN ADULTS USING SPECIFIED DOSAGE FORM
250MG;EQ 10MG BASE;12.5MG TALICIA TALICIA HOLDINGS N213004 Nov. 1, 2019 RX CAPSULE, DELAYED RELEASE ORAL 9050263 Feb. 12, 2034 TREATMENT OF H. PYLORI INFECTION IN ADULTS
250MG;EQ 10MG BASE;12.5MG TALICIA TALICIA HOLDINGS N213004 Nov. 1, 2019 RX CAPSULE, DELAYED RELEASE ORAL 9498445 Feb. 12, 2034 TREATMENT OF H. PYLORI INFECTION IN ADULTS
250MG;EQ 10MG BASE;12.5MG TALICIA TALICIA HOLDINGS N213004 Nov. 1, 2019 RX CAPSULE, DELAYED RELEASE ORAL 9603806 Feb. 12, 2034 TREATMENT OF H. PYLORI INFECTION IN ADULTS
2MG/ML;84MG/ML KONVOMEP AZURITY N213593 Aug. 30, 2022 RX FOR SUSPENSION ORAL 11911473 July 16, 2039 REDUCTION OF RISK OF UPPER GASTROINTESTINAL BLEEDING IN CRITICALLY ILL PATIENTS
2MG/ML;84MG/ML KONVOMEP AZURITY N213593 Aug. 30, 2022 RX FOR SUSPENSION ORAL 11911473 July 16, 2039 SHORT TERM TREATMENT OF ACTIVE BENIGN GASTRIC ULCER
2MG/ML;84MG/ML KONVOMEP AZURITY N213593 Aug. 30, 2022 RX FOR SUSPENSION ORAL 11771686 March 1, 2040 SHORT TERM TREATMENT OF ACTIVE BENIGN GASTRIC ULCER
250MG;EQ 10MG BASE;12.5MG TALICIA TALICIA HOLDINGS N213004 Nov. 1, 2019 RX CAPSULE, DELAYED RELEASE ORAL 11878011 May 27, 2042 TREATMENT OF HELICOBACTER PYLORI INFECTION USING THE ADMINISTERED DOSAGE FORMS IN ADULTS WITH DIFFERENT BODY MASS INDEX DETERMINATIONS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
250MG;EQ 10MG BASE;12.5MG TALICIA TALICIA HOLDINGS N213004 Nov. 1, 2019 RX CAPSULE, DELAYED RELEASE ORAL Nov. 1, 2022 NEW PRODUCT
250MG;EQ 10MG BASE;12.5MG TALICIA TALICIA HOLDINGS N213004 Nov. 1, 2019 RX CAPSULE, DELAYED RELEASE ORAL Nov. 1, 2027 GENERATING ANTIBIOTIC INCENTIVES NOW

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Potassium-transporting ATPase Transporter INHIBITOR IC50 5.70 CHEMBL CHEMBL
Multidrug resistance protein 1 Transporter IC50 4.05 WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter IC50 4.75 CHEMBL
Cytochrome P450 2C9 Enzyme Ki 4.35 WOMBAT-PK
Cytochrome P450 1A2 Enzyme IC50 4.74 WOMBAT-PK
Cytochrome P450 2C19 Enzyme Ki 5.30 WOMBAT-PK
Fatty acid synthase Enzyme Ki 5.47 CHEMBL
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Enzyme IC50 4.70 CHEMBL
Glutathione S-transferase omega-1 Enzyme IC50 5.34 CHEMBL
Cytosolic endo-beta-N-acetylglucosaminidase Enzyme IC50 4.60 CHEMBL
Cytochrome P450 3A4 Enzyme Km 4.31 WOMBAT-PK
Potassium-transporting ATPase Enzyme IC50 5.42 CHEMBL
Potassium-transporting ATPase Enzyme IC50 6.16 SCIENTIFIC LITERATURE

External reference:

IDSource
4019439 VUID
N0000147569 NUI
D00455 KEGG_DRUG
95510-70-6 SECONDARY_CAS_RN
95382-33-5 SECONDARY_CAS_RN
4019439 VANDF
4025702 VANDF
4029343 VANDF
C0028978 UMLSCUI
CHEBI:7772 CHEBI
1C6 PDB_CHEM_ID
CHEMBL1503 ChEMBL_ID
CHEMBL2105294 ChEMBL_ID
CHEMBL1567328 ChEMBL_ID
DB00338 DRUGBANK_ID
D009853 MESH_DESCRIPTOR_UI
4594 PUBCHEM_CID
4279 IUPHAR_LIGAND_ID
5081 INN_ID
KG60484QX9 UNII
1792108 RXNORM
174165 MMSL
34509 MMSL
38031 MMSL
45807 MMSL
5201 MMSL
d00325 MMSL
d05770 MMSL
003476 NDDF
005065 NDDF
006090 NDDF
25673006 SNOMEDCT_US
384973006 SNOMEDCT_US
387137007 SNOMEDCT_US
420878004 SNOMEDCT_US
441570004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Good Sense Omeprazole and Sodium Bicarbonate HUMAN OTC DRUG LABEL 2 0113-0058 CAPSULE, GELATIN COATED 20 mg ORAL ANDA 15 sections
good sense omeprazole HUMAN OTC DRUG LABEL 1 0113-0520 TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE 20 mg ORAL NDA 15 sections
Good Sense Omeprazole HUMAN OTC DRUG LABEL 1 0113-0915 TABLET, DELAYED RELEASE 20 mg ORAL NDA 15 sections
Good Sense Omeprazole HUMAN OTC DRUG LABEL 1 0113-1723 TABLET, DELAYED RELEASE 20 mg ORAL NDA 15 sections
good sense omeprazole delayed release HUMAN OTC DRUG LABEL 1 0113-1803 TABLET, DELAYED RELEASE 20 mg ORAL NDA 15 sections
GOOD SENSE OMEPRAZOLE HUMAN OTC DRUG LABEL 1 0113-6010 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
omeprazole HUMAN OTC DRUG LABEL 1 0363-0007 TABLET, DELAYED RELEASE 20 mg ORAL NDA 15 sections
Omeprazole Magnesium HUMAN OTC DRUG LABEL 1 0363-0042 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
Omeprazole and sodium bicarbonate HUMAN OTC DRUG LABEL 2 0363-0732 CAPSULE, GELATIN COATED 20 mg ORAL ANDA 15 sections
Omeprazole and sodium bicarbonate HUMAN OTC DRUG LABEL 2 0363-0732 CAPSULE, GELATIN COATED 20 mg ORAL ANDA 15 sections
omeprazole HUMAN OTC DRUG LABEL 1 0363-0915 TABLET, DELAYED RELEASE 20 mg ORAL NDA 15 sections
Acid Reducer Human OTC Drug Label 1 0363-1008 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 16 sections
Omeprazole HUMAN OTC DRUG LABEL 1 0363-1607 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
omeprazole HUMAN OTC DRUG LABEL 1 0363-1819 TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE 20 mg ORAL NDA 15 sections
OMEPRAZOLE HUMAN OTC DRUG LABEL 1 0363-4099 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
omeprazole HUMAN OTC DRUG LABEL 1 0363-6089 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 15 sections
omeprazole HUMAN OTC DRUG LABEL 1 0363-6101 TABLET, DELAYED RELEASE 20 mg ORAL NDA 15 sections
Omeprazole HUMAN OTC DRUG LABEL 1 0363-9510 TABLET, DELAYED RELEASE 20.60 mg ORAL ANDA 14 sections
Omeprazole HUMAN OTC DRUG LABEL 1 0363-9980 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 16 sections
Acid Reducer Human OTC Drug Label 1 0536-1322 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 16 sections
rugby omeprazole HUMAN OTC DRUG LABEL 1 0536-1448 TABLET, DELAYED RELEASE 20 mg ORAL NDA 15 sections
Omeprazole HUMAN PRESCRIPTION DRUG LABEL 1 0615-8079 CAPSULE, DELAYED RELEASE 40 mg ORAL ANDA 28 sections
Omeprazole HUMAN PRESCRIPTION DRUG LABEL 1 0615-8406 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 28 sections
Omeprazole HUMAN PRESCRIPTION DRUG LABEL 1 0781-2234 CAPSULE, DELAYED RELEASE 40 mg ORAL ANDA 27 sections
Omeprazole HUMAN PRESCRIPTION DRUG LABEL 1 0781-2785 CAPSULE, DELAYED RELEASE 10 mg ORAL ANDA 27 sections
Omeprazole HUMAN PRESCRIPTION DRUG LABEL 1 0781-2790 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
Omeprazole HUMAN PRESCRIPTION DRUG LABEL 1 0781-2859 CAPSULE, DELAYED RELEASE 10 mg ORAL ANDA 27 sections
Omeprazole HUMAN PRESCRIPTION DRUG LABEL 1 0781-2868 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
Omeprazole HUMAN PRESCRIPTION DRUG LABEL 1 0904-6917 CAPSULE, DELAYED RELEASE 20 mg ORAL ANDA 28 sections
Acid Reducer Human OTC Drug Label 1 10202-722 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 16 sections