rabeprazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antiulcer, benzimidazole derivatives 2350 117976-89-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sodium rabeprazole
  • rabeprazole
  • rabeprazole sodium
  • habeprazole
  • aciphex
  • rabeprazole sodium salt
A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
  • Molecular weight: 359.44
  • Formula: C18H21N3O3S
  • CLOGP: 2.08
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 77.10
  • ALOGS: -3.03
  • ROTB: 8
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.50 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 52 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.04 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IGF1R,ITK,JAK2,JAK3,MAP3K1,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 57
kinase-selectivity-class AXL,BRAF 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 3.936 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
rat-kpuu-brain Rat brain Kpuu 0.139 % High 1

Approvals:

DateAgencyCompanyOrphan
Aug. 19, 1999 FDA EISAI INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Obstructive airways disorder 286.36 10.11 205 72162 25664 90530416
Eosinophilic bronchitis 264.80 10.11 68 72299 575 90555505
Eosinophil count increased 252.29 10.11 147 72220 12934 90543146
Pemphigus 232.82 10.11 6 72361 326858 90229222
Maternal exposure during pregnancy 199.50 10.11 26 72341 360037 90196043
Synovitis 175.20 10.11 27 72340 329725 90226355
Pericarditis 172.27 10.11 11 72356 270140 90285940
Vital capacity decreased 172.22 10.11 62 72305 1757 90554323
Reversible airways obstruction 170.67 10.11 63 72304 1920 90554160
Glossodynia 169.48 10.11 27 72340 321752 90234328
Swollen tongue 169.26 10.11 196 72171 45760 90510320
Hand deformity 167.55 10.11 20 72347 296342 90259738
Dysphonia 165.34 10.11 227 72140 62857 90493223
Sputum culture positive 162.85 10.11 63 72304 2190 90553890
Wound 162.81 10.11 24 72343 302956 90253124
Anti-cyclic citrullinated peptide antibody positive 155.73 10.11 8 72359 236425 90319655
Duodenal ulcer perforation 154.08 10.11 5 72362 221283 90334797
Loss of employment 145.67 10.11 63 72304 2924 90553156
Systemic lupus erythematosus 144.78 10.11 54 72313 361842 90194238
Bronchial secretion retention 143.47 10.11 66 72301 3549 90552531
Full blood count abnormal 139.68 10.11 159 72208 36438 90519642
Neutrophilia 136.00 10.11 74 72293 5704 90550376
Angioedema 133.11 10.11 208 72159 64668 90491412
Polyp 126.87 10.11 78 72289 7566 90548514
Helicobacter infection 124.10 10.11 17 72350 226833 90329247
Alopecia 120.11 10.11 131 72236 494940 90061140
Oral discomfort 118.12 10.11 84 72283 10399 90545681
Swelling face 113.50 10.11 220 72147 81132 90474948
Rheumatoid factor positive 112.41 10.11 6 72361 171644 90384436
Secondary immunodeficiency 110.80 10.11 47 72320 2079 90554001
Hepatic steatosis 106.04 10.11 139 72228 36806 90519274
Sputum purulent 101.98 10.11 39 72328 1313 90554767
Cough 98.68 10.11 566 71801 368396 90187684
Hepatic function abnormal 97.17 10.11 150 72217 46138 90509942
Multiple allergies 96.80 10.11 87 72280 15059 90541021
Nicotine dependence 96.45 10.11 35 72332 1015 90555065
Blood folate decreased 94.00 10.11 39 72328 1631 90554449
Interstitial lung disease 90.40 10.11 193 72174 76212 90479868
Discomfort 89.63 10.11 54 72313 274281 90281799
Platelet count decreased 89.05 10.11 276 72091 136693 90419387
Drug ineffective for unapproved indication 89.04 10.11 177 72190 66467 90489613
Exposure during pregnancy 83.55 10.11 43 72324 238367 90317713
C-reactive protein abnormal 78.83 10.11 6 72361 127423 90428657
Upper-airway cough syndrome 77.70 10.11 77 72290 15058 90541022
Nasal disorder 77.03 10.11 42 72325 3250 90552830
Drug eruption 76.08 10.11 116 72251 35291 90520789
Irritable bowel syndrome 71.81 10.11 38 72329 207410 90348670
Hypomagnesaemia 71.45 10.11 113 72254 35475 90520605
Pulmonary mass 68.63 10.11 99 72268 28673 90527407
Completed suicide 68.23 10.11 16 72351 145042 90411038
Gastrooesophageal reflux disease 67.89 10.11 288 72079 166049 90390031
Blood pressure increased 67.42 10.11 324 72043 196893 90359187
Blood pressure fluctuation 67.38 10.11 137 72230 52276 90503804
Cardiac failure congestive 66.11 10.11 201 72166 98493 90457587
Liver injury 65.59 10.11 27 72340 170540 90385540
Type 2 diabetes mellitus 64.98 10.11 41 72326 203203 90352877
Cardiac failure 64.20 10.11 213 72154 109283 90446797
Tonsillar disorder 64.06 10.11 27 72340 1175 90554905
Bacterial infection 63.88 10.11 86 72281 23358 90532722
Impaired healing 63.60 10.11 56 72311 234143 90321937
Facet joint syndrome 62.69 10.11 4 72363 98385 90457695
Gastric disorder 60.23 10.11 101 72266 33283 90522797
Colitis microscopic 59.57 10.11 58 72309 11101 90544979
Arthropathy 58.87 10.11 128 72239 366114 90189966
Gastric polyps 56.27 10.11 39 72328 4633 90551447
Blister 54.83 10.11 74 72293 254924 90301156
Peripheral venous disease 54.72 10.11 3 72364 83918 90472162
Psoriatic arthropathy 54.64 10.11 61 72306 228274 90327806
Cholecystitis chronic 54.20 10.11 52 72315 9774 90546306
Prescribed overdose 54.12 10.11 7 72360 97618 90458462
Wound infection 53.61 10.11 10 72357 106392 90449688
Myocardial infarction 53.34 10.11 196 72171 105776 90450304
Hiatus hernia 52.96 10.11 82 72285 25279 90530801
Bursitis 51.99 10.11 20 72347 131634 90424446
Hepatic enzyme increased 51.66 10.11 134 72233 360602 90195478
Injury 50.27 10.11 50 72317 197299 90358781
Heart rate increased 49.60 10.11 200 72167 112702 90443378
Toxicity to various agents 48.43 10.11 98 72269 287748 90268332
Lichen sclerosus 48.26 10.11 23 72344 1340 90554740
Cestode infection 46.62 10.11 15 72352 299 90555781
Grip strength decreased 46.00 10.11 9 72358 92567 90463513
Drug abuse 45.41 10.11 6 72361 82341 90473739
General physical health deterioration 44.89 10.11 140 72227 354975 90201105
Erythema multiforme 44.69 10.11 52 72315 12194 90543886
Blood pressure systolic increased 43.04 10.11 123 72244 58222 90497858
Renal impairment 42.58 10.11 182 72185 105239 90450841
Fibromyalgia 41.23 10.11 63 72304 206206 90349874
Neutrophil count decreased 40.90 10.11 138 72229 71394 90484686
Infusion related reaction 40.51 10.11 183 72184 416597 90139483
Hyponatraemia 40.40 10.11 212 72155 133326 90422754
Pneumothorax spontaneous 39.85 10.11 18 72349 927 90555153
Treatment failure 38.99 10.11 119 72248 303809 90252271
Obesity 38.50 10.11 18 72349 105489 90450591
Mobility decreased 38.34 10.11 90 72277 250644 90305436
Hypertonic bladder 38.17 10.11 30 72337 4318 90551762
Stomatitis 37.83 10.11 104 72263 274594 90281486
Sputum culture 37.79 10.11 13 72354 321 90555759
Hypokalaemia 37.52 10.11 205 72162 130911 90425169
Gait inability 37.41 10.11 37 72330 146419 90409661
Adverse event 37.09 10.11 24 72343 117394 90438686
Infection 37.00 10.11 156 72211 361938 90194142
Eosinophil count decreased 36.79 10.11 26 72341 3186 90552894
Confusional state 36.68 10.11 171 72196 386034 90170046
Tubulointerstitial nephritis and uveitis syndrome 36.36 10.11 12 72355 260 90555820
Sleep disorder 36.30 10.11 64 72303 197966 90358114
Product dose omission issue 36.15 10.11 116 72251 291571 90264509
Cerebral infarction 35.95 10.11 71 72296 26525 90529555
Lung diffusion test decreased 35.59 10.11 16 72351 815 90555265
Malaise 34.84 10.11 659 71708 585327 89970753
Tubulointerstitial nephritis 34.67 10.11 68 72299 25275 90530805
Abdominal distension 34.59 10.11 200 72167 130401 90425679
Anaemia 34.57 10.11 432 71935 352370 90203710
Magnesium deficiency 34.16 10.11 15 72352 722 90555358
Death 34.10 10.11 219 72148 456332 90099748
Prescribed underdose 33.86 10.11 9 72358 75010 90481070
Swelling 33.38 10.11 197 72170 418861 90137219
Blood pressure diastolic decreased 33.15 10.11 69 72298 26757 90529323
Premenstrual syndrome 32.81 10.11 15 72352 795 90555285
Fall 32.57 10.11 553 71814 481257 90074823
Enterocolitis haemorrhagic 32.17 10.11 19 72348 1713 90554367
Therapy non-responder 32.17 10.11 37 72330 136667 90419413
Malignant polyp 31.83 10.11 10 72357 184 90555896
Peripheral swelling 31.44 10.11 197 72170 412909 90143171
Blood alkaline phosphatase increased 31.32 10.11 97 72270 47982 90508098
Blepharospasm 30.67 10.11 4 72363 55441 90500639
Respiratory tract infection 30.33 10.11 110 72257 58968 90497112
Ill-defined disorder 30.19 10.11 64 72303 184827 90371253
Haemoglobin decreased 30.11 10.11 227 72140 161729 90394351
Road traffic accident 30.10 10.11 25 72342 107601 90448479
Pulmonary fibrosis 30.03 10.11 25 72342 107478 90448602
Abdominal pain 30.02 10.11 463 71904 395258 90160822
Fluid replacement 29.49 10.11 13 72354 632 90555448
Hypereosinophilic syndrome 29.38 10.11 11 72356 349 90555731
Blood pressure decreased 29.24 10.11 128 72239 74767 90481313
Intentional product use issue 29.20 10.11 83 72284 216809 90339271
Night sweats 29.07 10.11 36 72331 128730 90427350
Product use issue 29.05 10.11 150 72217 329769 90226311
Hypocalcaemia 29.03 10.11 87 72280 42281 90513799
Aspartate aminotransferase increased 28.15 10.11 159 72208 102778 90453302
Limb mass 28.12 10.11 23 72344 3505 90552575
Hip arthroplasty 27.80 10.11 13 72354 76195 90479885
Sciatica 27.80 10.11 24 72343 101358 90454722
Blood iron increased 27.54 10.11 18 72349 1941 90554139
Body temperature fluctuation 27.42 10.11 19 72348 2256 90553824
Biliary dyskinesia 27.39 10.11 20 72347 2579 90553501
Uveitis 27.21 10.11 47 72320 15856 90540224
Iron deficiency anaemia 27.09 10.11 59 72308 23603 90532477
Gamma-glutamyltransferase increased 27.01 10.11 79 72288 37873 90518207
Lower respiratory tract infection 26.84 10.11 106 72261 250553 90305527
Medication overuse headache 26.66 10.11 16 72351 1485 90554595
Taste disorder 26.63 10.11 8 72359 61538 90494542
Rheumatoid arthritis 26.63 10.11 422 71945 362192 90193888
Headache 26.62 10.11 888 71479 861858 89694222
Condition aggravated 26.24 10.11 327 72040 595218 89960862
Alanine aminotransferase increased 26.16 10.11 173 72194 118165 90437915
Arthralgia 26.00 10.11 809 71558 777713 89778367
Rib fracture 25.92 10.11 62 72305 26373 90529707
Adenocarcinoma 25.82 10.11 21 72346 3175 90552905
Intra-abdominal fluid collection 25.78 10.11 20 72347 2824 90553256
Joint range of motion decreased 25.62 10.11 43 72324 135600 90420480
Lip pruritus 25.47 10.11 15 72352 1345 90554735
Product use in unapproved indication 25.23 10.11 161 72206 336075 90220005
Polymyalgia rheumatica 24.95 10.11 25 72342 4952 90551128
Polymenorrhoea 24.90 10.11 15 72352 1402 90554678
Retinal toxicity 24.85 10.11 15 72352 1407 90554673
Upper respiratory tract inflammation 24.68 10.11 19 72348 2653 90553427
Chronic kidney disease 24.55 10.11 92 72275 50099 90505981
Dyschromatopsia 24.47 10.11 12 72355 745 90555335
Productive cough 24.45 10.11 124 72243 76939 90479141
Barotrauma 24.17 10.11 8 72359 175 90555905
Tibia fracture 24.16 10.11 27 72340 6060 90550020
Aortic dissection 24.12 10.11 18 72349 2399 90553681
Knee arthroplasty 23.66 10.11 19 72348 83163 90472917
Fatigue 23.62 10.11 722 71645 1153301 89402779
Blood cholesterol increased 23.54 10.11 86 72281 207926 90348154
Neutropenia 23.51 10.11 96 72271 224808 90331272
Forced expiratory volume decreased 23.46 10.11 26 72341 5782 90550298
Hypoaesthesia 23.29 10.11 151 72216 314059 90242021
Medication error 23.25 10.11 20 72347 84632 90471448
Intervertebral disc degeneration 23.21 10.11 46 72321 17228 90538852
Non-economic loss 23.05 10.11 5 72362 18 90556062
Sinusitis 22.91 10.11 170 72197 342918 90213162
Coeliac disease 22.88 10.11 4 72363 44606 90511474
No adverse event 22.72 10.11 13 72354 67969 90488111
Spinal compression fracture 22.33 10.11 42 72325 15136 90540944
Lip infection 22.12 10.11 7 72360 132 90555948
Epilepsy 21.89 10.11 20 72347 82186 90473894
Nerve compression 21.83 10.11 34 72333 10532 90545548
Akathisia 21.80 10.11 35 72332 11124 90544956
Asthma 21.79 10.11 292 72075 241868 90314212
Cystitis 21.62 10.11 108 72259 66610 90489470
Menstruation delayed 21.47 10.11 16 72351 2129 90553951
Communication disorder 21.34 10.11 19 72348 3247 90552833
Oxygen saturation decreased 21.31 10.11 153 72214 107330 90448750
Hypoparathyroidism 21.31 10.11 12 72355 989 90555091
Focal segmental glomerulosclerosis 21.24 10.11 15 72352 1836 90554244
Q fever 21.07 10.11 7 72360 155 90555925
Red blood cell sedimentation rate increased 20.93 10.11 21 72346 82574 90473506
Red cell distribution width increased 20.79 10.11 36 72331 12171 90543909
Abdominal tenderness 20.67 10.11 31 72336 9293 90546787
Intensive care 20.59 10.11 13 72354 1321 90554759
Haemolytic anaemia 20.58 10.11 35 72332 11662 90544418
Pneumonia 20.22 10.11 659 71708 637400 89918680
Nail disorder 20.16 10.11 11 72356 59056 90497024
Multiple fractures 20.08 10.11 31 72336 9531 90546549
Radioallergosorbent test positive 20.06 10.11 5 72362 37 90556043
Hepatitis chronic active 20.00 10.11 6 72361 94 90555986
Hepatotoxicity 19.76 10.11 6 72361 45836 90510244
Foetal exposure during pregnancy 19.69 10.11 5 72362 42970 90513110
Aphthous ulcer 19.67 10.11 43 72324 17244 90538836
Dysstasia 19.64 10.11 54 72313 24998 90531082
Metamorphopsia 19.54 10.11 13 72354 1444 90554636
Rubber sensitivity 19.53 10.11 17 72350 2820 90553260
Blood pressure systolic abnormal 19.44 10.11 46 72321 19432 90536648
Adverse drug reaction 19.38 10.11 40 72327 116661 90439419
Nausea 19.38 10.11 1077 71290 1109239 89446841
Clitoris abscess 19.26 10.11 4 72363 11 90556069
Lower respiratory tract infection viral 18.94 10.11 11 72356 961 90555119
Premature delivery 18.77 10.11 4 72363 38758 90517322
Polyglandular disorder 18.55 10.11 7 72360 227 90555853
Abdominal discomfort 18.50 10.11 269 72098 477059 90079021
Gallbladder injury 18.36 10.11 12 72355 1294 90554786
Musculoskeletal stiffness 18.36 10.11 150 72217 296382 90259698
Melaena 18.04 10.11 65 72302 34732 90521348
Stress 17.99 10.11 119 72248 81276 90474804
Exostosis 17.98 10.11 10 72357 53124 90502956
Pregnancy 17.86 10.11 14 72353 62033 90494047
Diabetic neuropathy 17.66 10.11 20 72347 4554 90551526
Therapeutic reaction time decreased 17.66 10.11 18 72349 3640 90552440
Gastritis 17.56 10.11 73 72294 41680 90514400
Gastric cancer 17.40 10.11 21 72346 5115 90550965
Myalgia 17.36 10.11 215 72152 174910 90381170
Intentional product misuse 17.29 10.11 28 72339 89576 90466504
Memory impairment 17.17 10.11 90 72277 197154 90358926
Respiratory fume inhalation disorder 17.12 10.11 6 72361 157 90555923
Gastric dysplasia 17.07 10.11 4 72363 22 90556058
Oral discharge 17.01 10.11 6 72361 160 90555920
Colon cancer 17.00 10.11 31 72336 10913 90545167
Joint injury 16.92 10.11 61 72306 32603 90523477
Erosive oesophagitis 16.87 10.11 13 72354 1818 90554262
Pneumonia aspiration 16.77 10.11 71 72296 40869 90515211
Eye contusion 16.66 10.11 15 72352 2601 90553479
Blood pressure systolic decreased 16.66 10.11 28 72339 9242 90546838
Spondyloarthropathy 16.61 10.11 11 72356 1213 90554867
Rubella 16.53 10.11 6 72361 174 90555906
Disseminated intravascular coagulation 16.46 10.11 46 72321 21492 90534588
Vulvovaginal pruritus 16.35 10.11 18 72349 3975 90552105
Coeliac artery occlusion 16.32 10.11 3 72364 3 90556077
Tooth fracture 16.26 10.11 33 72334 12567 90543513
Visual impairment 16.13 10.11 53 72314 132312 90423768
White blood cell count decreased 16.07 10.11 204 72163 166905 90389175
Blood bilirubin increased 15.99 10.11 73 72294 43397 90512683
Migraine with aura 15.76 10.11 16 72351 3220 90552860
Cataract 15.69 10.11 105 72262 71987 90484093
Skin infection 15.51 10.11 40 72327 17824 90538256
Skin mass 15.48 10.11 24 72343 7406 90548674
Abdominal pain upper 15.43 10.11 361 72006 332313 90223767
Osteonecrosis of jaw 15.39 10.11 67 72300 39036 90517044
Gastrointestinal haemorrhage 15.38 10.11 124 72243 90124 90465956
Stress at work 15.35 10.11 11 72356 1378 90554702
Balance disorder 15.27 10.11 131 72236 96949 90459131
Microcytic anaemia 15.27 10.11 17 72350 3801 90552279
Chorioretinal disorder 14.99 10.11 5 72362 112 90555968
Amnesia 14.98 10.11 41 72326 108464 90447616
Pigmentation disorder 14.97 10.11 21 72346 5928 90550152
Gallbladder disorder 14.85 10.11 42 72325 19761 90536319
Emphysema 14.71 10.11 31 72336 12124 90543956
Ischaemic stroke 14.70 10.11 45 72322 22121 90533959
Walking aid user 14.68 10.11 5 72362 35501 90520579
Serum sickness 14.56 10.11 16 72351 3526 90552554
Gastric mucosal lesion 14.52 10.11 8 72359 632 90555448
Oedema 14.46 10.11 97 72270 200198 90355882
Heat stroke 14.43 10.11 9 72358 895 90555185
Pharyngeal oedema 14.27 10.11 33 72334 13738 90542342
Renal disorder 14.24 10.11 64 72303 37795 90518285
Ear infection 14.23 10.11 21 72346 69754 90486326
Product quality issue 14.20 10.11 26 72341 79299 90476781
Blood glucose increased 14.19 10.11 127 72240 95119 90460961
Ascites 13.89 10.11 75 72292 47665 90508415
Compression fracture 13.78 10.11 25 72342 8764 90547316
Weight decreased 13.77 10.11 399 71968 379511 90176569
Urinary incontinence 13.75 10.11 63 72304 37503 90518577
Overdose 13.70 10.11 72 72295 157637 90398443
Hepatocellular carcinoma 13.68 10.11 13 72354 2415 90553665
Hypoaesthesia oral 13.62 10.11 35 72332 15565 90540515
Liver iron concentration abnormal 13.62 10.11 4 72363 58 90556022
C-reactive protein increased 13.52 10.11 87 72280 181302 90374778
Pancreatitis acute 13.39 10.11 56 72311 32059 90524021
Auricular swelling 13.37 10.11 4 72363 62 90556018
Haemorrhage subcutaneous 13.37 10.11 15 72352 3381 90552699
Gingival pain 13.32 10.11 26 72341 9626 90546454
Product substitution issue 13.31 10.11 38 72329 17970 90538110
Intentional overdose 13.30 10.11 35 72332 93799 90462281
Dyspnoea exertional 13.24 10.11 101 72266 72187 90483893
Constipation 13.23 10.11 305 72062 280090 90275990
Back pain 13.16 10.11 339 72028 316836 90239244
Bed bug infestation 13.14 10.11 4 72363 66 90556014
Leukaemia 13.12 10.11 18 72349 4974 90551106
Mucosal inflammation 13.12 10.11 16 72351 57609 90498471
Hyperuricaemia 13.02 10.11 21 72346 6698 90549382
Jaundice 13.01 10.11 56 72311 32461 90523619
Hepatitis B 12.96 10.11 17 72350 4502 90551578
Hypochromic anaemia 12.95 10.11 12 72355 2159 90553921
Generalised oedema 12.93 10.11 39 72328 19014 90537066
Muscle spasticity 12.92 10.11 6 72361 35316 90520764
Stress fracture 12.88 10.11 24 72343 8587 90547493
Anaemia folate deficiency 12.87 10.11 7 72360 539 90555541
Onychomycosis 12.70 10.11 7 72360 37369 90518711
Macule 12.64 10.11 13 72354 2656 90553424
Pneumonitis 12.58 10.11 69 72298 44101 90511979
Contusion 12.56 10.11 134 72233 251082 90304998
Contraindicated product administered 12.53 10.11 180 72187 319959 90236121
Psoriasis 12.53 10.11 68 72299 147686 90408394
Device issue 12.49 10.11 4 72363 29533 90526547
Sedation 12.49 10.11 12 72355 48159 90507921
Diabetes mellitus inadequate control 12.45 10.11 38 72329 18646 90537434
Blood iron decreased 12.41 10.11 37 72330 17922 90538158
Atrial fibrillation 12.37 10.11 162 72205 133449 90422631
Pulmonary function test abnormal 12.36 10.11 13 72354 2726 90553354
Gastric ulcer 12.35 10.11 49 72318 27399 90528681
Blood lactate dehydrogenase increased 12.24 10.11 47 72320 25885 90530195
Hepatic encephalopathy 12.13 10.11 31 72336 13741 90542339
Oropharyngeal pain 12.10 10.11 143 72224 115044 90441036
Restrictive pulmonary disease 12.09 10.11 12 72355 2350 90553730
Chest discomfort 12.09 10.11 166 72201 138199 90417881
Ankylosing spondylitis 12.02 10.11 30 72337 13103 90542977
Dengue fever 11.98 10.11 8 72359 894 90555186
Breast pain 11.95 10.11 26 72341 10392 90545688
Head injury 11.94 10.11 53 72314 31135 90524945
Periodontitis 11.84 10.11 15 72352 3838 90552242
Enterocolitis 11.83 10.11 26 72341 10464 90545616
Femur fracture 11.82 10.11 70 72297 46012 90510068
Enteritis infectious 11.79 10.11 12 72355 2423 90553657
Colon cancer stage II 11.77 10.11 5 72362 222 90555858
Adenocarcinoma gastric 11.74 10.11 7 72360 642 90555438
Lupus-like syndrome 11.73 10.11 13 72354 48833 90507247
Hypophosphataemia 11.62 10.11 32 72335 14822 90541258
Pseudocholinesterase deficiency 11.62 10.11 4 72363 99 90555981
Palpitations 11.52 10.11 163 72204 136565 90419515
Lung neoplasm malignant 11.46 10.11 44 72323 24229 90531851
Diverticulum 11.44 10.11 28 72339 12085 90543995
Giardiasis 11.40 10.11 4 72363 105 90555975
Gallbladder enlargement 11.36 10.11 8 72359 975 90555105
Catheter site hypersensitivity 11.33 10.11 4 72363 107 90555973
Therapy interrupted 11.32 10.11 14 72353 50094 90505986
Concomitant disease aggravated 11.28 10.11 27 72340 11491 90544589
Trigger finger 11.19 10.11 17 72350 5153 90550927
Femoral neck fracture 11.13 10.11 25 72342 10208 90545872
Hepatitis 11.12 10.11 25 72342 70714 90485366
Subacute cutaneous lupus erythematosus 11.10 10.11 14 72353 3568 90552512
Hyperthyroidism 11.06 10.11 36 72331 18274 90537806
Intramedullary rod insertion 11.06 10.11 11 72356 2161 90553919
Blood creatine phosphokinase increased 10.97 10.11 55 72312 33968 90522112
Joint swelling 10.96 10.11 312 72055 502988 90053092
Beta-N-acetyl-D-glucosaminidase increased 10.89 10.11 3 72364 34 90556046
Nasal ulcer 10.88 10.11 12 72355 2654 90553426
Inflammatory pain 10.86 10.11 8 72359 1045 90555035
Muscular weakness 10.84 10.11 109 72258 206557 90349523
Joint space narrowing 10.84 10.11 7 72360 740 90555340
Immune-mediated enterocolitis 10.81 10.11 16 72351 4741 90551339
Liver disorder 10.80 10.11 146 72221 121123 90434957
Bone erosion 10.77 10.11 16 72351 53005 90503075
Pain in extremity 10.76 10.11 451 71916 450078 90106002
Disability 10.74 10.11 10 72357 40735 90515345
Gastrointestinal bacterial infection 10.68 10.11 8 72359 1072 90555008
Mouth haemorrhage 10.66 10.11 22 72345 8479 90547601
Joint instability 10.57 10.11 9 72358 1450 90554630
Fracture nonunion 10.56 10.11 11 72356 2281 90553799
Incorrect route of product administration 10.56 10.11 15 72352 50611 90505469
Back injury 10.55 10.11 13 72354 46609 90509471
Cholelithiasis 10.55 10.11 75 72292 52431 90503649
Hypercapnia 10.48 10.11 19 72348 6658 90549422
Hypertension 10.48 10.11 456 71911 457076 90099004
Chronic hepatitis 10.27 10.11 8 72359 1137 90554943
Groin pain 10.25 10.11 27 72340 12186 90543894
Intertrigo 10.24 10.11 7 72360 813 90555267
Dorsal ramus syndrome 10.23 10.11 4 72363 143 90555937
Left atrial dilatation 10.22 10.11 10 72357 1926 90554154
Mean cell haemoglobin concentration decreased 10.21 10.11 15 72352 4413 90551667
Cross sensitivity reaction 10.20 10.11 12 72355 2845 90553235
Gastric antral vascular ectasia 10.17 10.11 7 72360 822 90555258
Dermatomyositis 10.17 10.11 13 72354 3357 90552723
Osmophobia 10.13 10.11 4 72363 147 90555933

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 164.66 11.41 293 43826 78169 42499047
Coombs positive haemolytic anaemia 153.21 11.41 55 44064 1180 42576036
Hepatic function abnormal 134.05 11.41 212 43907 51355 42525861
Needle fatigue 124.54 11.41 47 44072 1166 42576050
Lymphadenitis 118.56 11.41 56 44063 2455 42574761
Gait spastic 117.70 11.41 47 44072 1362 42575854
Relapsing-remitting multiple sclerosis 115.01 11.41 47 44072 1448 42575768
Hypertonic bladder 112.11 11.41 53 44066 2328 42574888
Toxicity to various agents 103.66 11.41 54 44065 229082 42348134
Cerebral hypoperfusion 101.99 11.41 39 44080 1004 42576212
Monoparesis 84.42 11.41 47 44072 2913 42574303
Death 80.41 11.41 237 43882 470948 42106268
Drug ineffective 76.34 11.41 365 43754 629832 41947384
Muscle spasticity 71.23 11.41 58 44061 6764 42570452
Off label use 70.33 11.41 382 43737 637953 41939263
Nocturia 69.96 11.41 74 44045 12038 42565178
Movement disorder 69.71 11.41 81 44038 14617 42562599
Cerebral infarction 68.66 11.41 119 44000 31050 42546166
Completed suicide 64.68 11.41 11 44108 96454 42480762
Parathyroid gland enlargement 63.97 11.41 18 44101 167 42577049
Upper respiratory fungal infection 63.13 11.41 18 44101 176 42577040
Haemolysis 61.54 11.41 62 44057 9527 42567689
Product dose omission issue 60.50 11.41 43 44076 154322 42422894
Drug abuse 58.22 11.41 18 44101 104753 42472463
Oesophageal pain 58.21 11.41 26 44093 1000 42576216
Micturition urgency 57.15 11.41 66 44053 11832 42565384
Hepatic cancer 52.91 11.41 54 44065 8426 42568790
Central nervous system lesion 52.56 11.41 52 44067 7818 42569398
Tetanus 49.91 11.41 12 44107 55 42577161
Migraine with aura 48.06 11.41 22 44097 897 42576319
Product use in unapproved indication 47.91 11.41 73 44046 184383 42392833
Forced expiratory volume 46.96 11.41 13 44106 113 42577103
Blood pressure increased 45.13 11.41 217 43902 101711 42475505
Hypoparathyroidism secondary 44.93 11.41 14 44105 190 42577026
Hypomagnesaemia 43.35 11.41 93 44026 28395 42548821
Drug eruption 43.07 11.41 82 44037 22993 42554223
Migraine 42.22 11.41 86 44033 25328 42551888
Gastrointestinal motility disorder 41.87 11.41 30 44089 2891 42574325
Anorectal discomfort 41.44 11.41 27 44092 2228 42574988
Nipple inflammation 40.39 11.41 10 44109 53 42577163
Binocular eye movement disorder 39.45 11.41 14 44105 290 42576926
Clumsiness 38.01 11.41 24 44095 1876 42575340
Hypocalcaemia 37.59 11.41 91 44028 30082 42547134
Gastrooesophageal reflux disease 37.36 11.41 117 44002 44906 42532310
Mycobacterium test positive 36.73 11.41 15 44104 461 42576755
Dysarthria 33.54 11.41 104 44015 39703 42537513
Nerve degeneration 32.64 11.41 11 44108 194 42577022
Treatment failure 32.62 11.41 12 44107 62612 42514604
Constipation 32.21 11.41 282 43837 162009 42415207
Ataxia 32.21 11.41 59 44060 16066 42561150
Multiple sclerosis relapse 32.11 11.41 55 44064 14209 42563007
Hospitalisation 31.41 11.41 19 44100 74311 42502905
Bronchial disorder 31.37 11.41 19 44100 1379 42575837
Liver disorder 31.04 11.41 101 44018 39543 42537673
Lung diffusion test decreased 30.79 11.41 16 44103 863 42576353
Occupational dermatitis 30.77 11.41 9 44110 97 42577119
Nephrectomy 30.31 11.41 16 44103 891 42576325
Erectile dysfunction 29.82 11.41 74 44045 24839 42552377
Anxiety 29.51 11.41 217 43902 118343 42458873
Cerebellar stroke 29.44 11.41 14 44105 623 42576593
Vitamin D abnormal 29.37 11.41 8 44111 65 42577151
Pancreatic abscess 29.08 11.41 10 44109 188 42577028
Erythema multiforme 28.67 11.41 43 44076 9934 42567282
Intentional overdose 28.28 11.41 9 44110 51447 42525769
Muscular dystrophy 28.06 11.41 9 44110 135 42577081
Nipple disorder 27.79 11.41 10 44109 216 42577000
Hypergastrinaemia 27.79 11.41 10 44109 216 42577000
Tendon disorder 27.61 11.41 25 44094 3364 42573852
Infusion related reaction 26.56 11.41 129 43990 60677 42516539
Chronic kidney disease 26.51 11.41 108 44011 47133 42530083
Lung disorder 26.45 11.41 109 44010 47814 42529402
Abdominal mass 26.42 11.41 21 44098 2365 42574851
Chest discomfort 26.40 11.41 133 43986 63483 42513733
Pollakiuria 26.05 11.41 66 44053 22439 42554777
Hypoaesthesia 25.95 11.41 144 43975 71319 42505897
Decreased appetite 25.60 11.41 309 43810 192828 42384388
Interstitial granulomatous dermatitis 24.44 11.41 9 44110 208 42577008
Tetany 24.42 11.41 15 44104 1117 42576099
Renal cyst 24.32 11.41 40 44079 9999 42567217
Hepatic encephalopathy 24.24 11.41 53 44066 16389 42560827
Hepatocellular carcinoma 23.10 11.41 35 44084 8159 42569057
Platelet count decreased 23.07 11.41 232 43887 138349 42438867
Muscle strain 23.01 11.41 26 44093 4551 42572665
Balance disorder 22.95 11.41 104 44015 47541 42529675
Occupational exposure to air contaminants 22.62 11.41 8 44111 164 42577052
Carotid arteriosclerosis 22.62 11.41 19 44100 2313 42574903
Frustration tolerance decreased 22.48 11.41 22 44097 3264 42573952
Fatigue 22.43 11.41 317 43802 435324 42141892
Enterocolitis haemorrhagic 22.38 11.41 14 44105 1077 42576139
Mycobacterial infection 22.36 11.41 20 44099 2648 42574568
Haemochromatosis 22.13 11.41 14 44105 1098 42576118
Primary hypoparathyroidism 22.00 11.41 6 44113 49 42577167
Heart rate decreased 21.69 11.41 85 44034 36447 42540769
Sedation 21.50 11.41 3 44116 30472 42546744
Hepatic enzyme increased 21.35 11.41 99 44020 45685 42531531
Duodenal polyp 21.22 11.41 9 44110 305 42576911
Disseminated intravascular coagulation 21.08 11.41 65 44054 24729 42552487
Measles 21.08 11.41 9 44110 310 42576906
Gastric polyps 20.96 11.41 16 44103 1699 42575517
Dyslalia 20.65 11.41 11 44108 624 42576592
QRS axis abnormal 20.64 11.41 15 44104 1478 42575738
IIIrd nerve paresis 20.59 11.41 7 44112 127 42577089
Nasopharyngitis 20.46 11.41 153 43966 83843 42493373
Foetal exposure during pregnancy 20.11 11.41 12 44107 47299 42529917
Dizziness 20.11 11.41 366 43753 248888 42328328
Ocular discomfort 20.04 11.41 20 44099 3037 42574179
Sinus congestion 19.94 11.41 30 44089 6950 42570266
Hyperuricaemia 19.48 11.41 35 44084 9389 42567827
Feeling cold 19.33 11.41 42 44077 12931 42564285
Gastric cancer 18.77 11.41 29 44090 6874 42570342
Flatulence 18.72 11.41 63 44056 25089 42552127
Malaise 17.98 11.41 314 43805 211842 42365374
Cardiac failure 17.83 11.41 179 43940 106677 42470539
Complex regional pain syndrome 17.73 11.41 10 44109 635 42576581
Dermatitis acneiform 17.63 11.41 30 44089 7709 42569507
Hyperventilation 17.59 11.41 19 44100 3163 42574053
Skin wrinkling 17.53 11.41 9 44110 473 42576743
Intentional product misuse 17.53 11.41 23 44096 61877 42515339
Disease progression 17.35 11.41 83 44036 143573 42433643
Product substitution issue 17.34 11.41 37 44082 11253 42565963
Asthma 17.20 11.41 117 44002 62197 42515019
Haemorrhagic cerebral infarction 17.19 11.41 11 44108 880 42576336
Renal impairment 17.13 11.41 182 43937 110046 42467170
Tubulointerstitial nephritis 16.81 11.41 71 44048 31477 42545739
Dermatitis contact 16.80 11.41 22 44097 4481 42572735
General physical health deterioration 16.78 11.41 90 44029 151156 42426060
Sitting disability 16.73 11.41 7 44112 229 42576987
Ear discomfort 16.56 11.41 19 44100 3380 42573836
Idiopathic pulmonary fibrosis 16.42 11.41 22 44097 4582 42572634
Gastric adenoma 16.35 11.41 4 44115 20 42577196
Bronchiolitis 16.02 11.41 20 44099 3886 42573330
Thrombosis 16.01 11.41 29 44090 68482 42508734
Hyporesponsive to stimuli 15.83 11.41 13 44106 1533 42575683
Therapeutic product effect decreased 15.64 11.41 81 44038 39069 42538147
Pyomyositis 15.56 11.41 7 44112 274 42576942
Sneezing 14.94 11.41 25 44094 6338 42570878
Multiple organ dysfunction syndrome 14.91 11.41 51 44068 96984 42480232
Polymyalgia rheumatica 14.87 11.41 15 44104 2308 42574908
Leukocyte adhesion deficiency type I 14.74 11.41 4 44115 32 42577184
Premature baby 14.74 11.41 3 44116 23150 42554066
Macule 14.62 11.41 14 44105 2021 42575195
Nephroangiosclerosis 14.52 11.41 6 44113 190 42577026
Angina pectoris 14.51 11.41 70 44049 32826 42544390
Injection site pain 13.92 11.41 24 44095 57774 42519442
Blood calcium abnormal 13.87 11.41 9 44110 737 42576479
No adverse event 13.84 11.41 12 44107 39009 42538207
Delusion of replacement 13.73 11.41 6 44113 219 42576997
Blood pressure diastolic decreased 13.68 11.41 32 44087 10343 42566873
Bone density decreased 13.67 11.41 14 44105 2192 42575024
Abdominal rigidity 13.65 11.41 12 44107 1553 42575663
Tachypnoea 13.39 11.41 3 44116 21659 42555557
Folliculitis 13.26 11.41 22 44097 5536 42571680
Neurotoxicity 13.24 11.41 4 44115 23647 42553569
Sensory disturbance 13.15 11.41 25 44094 6998 42570218
Cholangitis 12.98 11.41 32 44087 10695 42566521
Neutrophil count decreased 12.97 11.41 111 44008 63304 42513912
Myocardial infarction 12.92 11.41 190 43929 123819 42453397
Obstruction 12.91 11.41 16 44103 3087 42574129
Speech disorder 12.87 11.41 62 44057 29059 42548157
Medical device implantation 12.81 11.41 8 44111 613 42576603
Thalamus haemorrhage 12.72 11.41 10 44109 1109 42576107
Angina unstable 12.65 11.41 33 44086 11415 42565801
Occupational exposure to product 12.63 11.41 7 44112 430 42576786
Stenosis 12.42 11.41 13 44106 2088 42575128
Device breakage 12.35 11.41 17 44102 3632 42573584
COVID-19 12.31 11.41 70 44049 115878 42461338
Liver abscess 12.30 11.41 20 44099 4950 42572266
Bile duct stone 12.27 11.41 15 44104 2852 42574364
Accidental exposure to product 12.26 11.41 3 44116 20390 42556826
Renal neoplasm 12.25 11.41 11 44108 1464 42575752
Incorrect route of product administration 12.09 11.41 5 44114 24300 42552916
Fall 12.08 11.41 323 43796 234197 42343019
Erythema of eyelid 12.07 11.41 11 44108 1492 42575724
Therapy interrupted 12.03 11.41 4 44115 22246 42554970
Blood pressure systolic abnormal 12.03 11.41 21 44098 5507 42571709
Defect conduction intraventricular 12.00 11.41 7 44112 474 42576742
Nail operation 11.80 11.41 3 44116 18 42577198
Serotonin syndrome 11.79 11.41 6 44113 25839 42551377
Asthma-chronic obstructive pulmonary disease overlap syndrome 11.73 11.41 11 44108 1548 42575668
Rhinitis 11.71 11.41 33 44086 11944 42565272
Benign prostatic hyperplasia 11.70 11.41 48 44071 21004 42556212
Hypoparathyroidism 11.68 11.41 8 44111 717 42576499
Allergy to vaccine 11.67 11.41 3 44116 19 42577197
Gastrointestinal polyp haemorrhage 11.56 11.41 7 44112 508 42576708
Insomnia 11.47 11.41 179 43940 118074 42459142
Mucosal inflammation 11.44 11.41 21 44098 49353 42527863

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Interstitial lung disease 248.59 9.76 454 101365 138880 110348600
Hepatic function abnormal 215.33 9.76 333 101486 88962 110398518
Synovitis 176.94 9.76 22 101797 274070 110213410
Maternal exposure during pregnancy 170.68 9.76 18 101801 254865 110232615
Obstructive airways disorder 157.10 9.76 203 101616 45946 110441534
Vital capacity decreased 152.26 9.76 61 101758 2012 110485468
Pemphigus 149.35 9.76 13 101806 214557 110272923
Reversible airways obstruction 147.84 9.76 63 101756 2436 110485044
Coombs positive haemolytic anaemia 146.36 9.76 55 101764 1522 110485958
Hypertonic bladder 145.84 9.76 79 101740 5223 110482257
Pericarditis 142.85 9.76 17 101802 219097 110268383
Toxicity to various agents 141.80 9.76 140 101679 480415 110007065
Duodenal ulcer perforation 141.29 9.76 5 101814 177695 110309785
Hand deformity 137.51 9.76 19 101800 218487 110268993
Loss of employment 133.30 9.76 64 101755 3280 110484200
Anti-cyclic citrullinated peptide antibody positive 132.36 9.76 9 101810 181975 110305505
Completed suicide 131.15 9.76 31 101788 242350 110245130
Eosinophil count increased 127.40 9.76 125 101694 20933 110466547
Glossodynia 127.03 9.76 25 101794 221979 110265501
Swollen tongue 126.19 9.76 211 101608 60151 110427329
Sputum culture positive 121.26 9.76 63 101756 3826 110483654
Needle fatigue 120.65 9.76 45 101774 1219 110486261
Dysphonia 119.96 9.76 235 101584 75694 110411786
Wound 119.17 9.76 34 101785 234403 110253077
Hypomagnesaemia 116.94 9.76 204 101615 60166 110427314
Systemic lupus erythematosus 116.78 9.76 44 101775 254294 110233186
Muscle injury 115.42 9.76 3 101816 140804 110346676
Blood pressure increased 114.90 9.76 507 101312 257866 110229614
Gait spastic 111.76 9.76 45 101774 1504 110485976
Bronchial secretion retention 111.43 9.76 65 101754 4959 110482521
Helicobacter infection 109.42 9.76 18 101801 181859 110305621
Drug eruption 108.76 9.76 185 101634 53474 110434006
Cerebral infarction 106.76 9.76 180 101639 51658 110435822
Platelet count decreased 106.12 9.76 457 101362 229986 110257494
Full blood count abnormal 101.61 9.76 184 101635 55868 110431612
Relapsing-remitting multiple sclerosis 98.94 9.76 45 101774 2037 110485443
Swelling face 97.37 9.76 243 101576 92078 110395402
Rheumatoid factor positive 97.23 9.76 6 101813 131634 110355846
Eosinophilic bronchitis 95.13 9.76 31 101788 555 110486925
Drug abuse 93.41 9.76 24 101795 177387 110310093
Angioedema 92.30 9.76 248 101571 98252 110389228
Multiple allergies 89.92 9.76 81 101738 12182 110475298
C-reactive protein abnormal 89.85 9.76 8 101811 129687 110357793
Lymphadenitis 88.57 9.76 58 101761 5435 110482045
Folliculitis 85.77 9.76 24 101795 167629 110319851
Nicotine dependence 83.55 9.76 35 101784 1296 110486184
Sputum purulent 80.77 9.76 38 101781 1860 110485620
Alopecia 79.84 9.76 133 101686 364620 110122860
Treatment failure 79.15 9.76 83 101736 277151 110210329
Death 78.93 9.76 353 101466 698516 109788964
Cardiac failure 78.74 9.76 362 101457 187264 110300216
Blood folate decreased 76.19 9.76 39 101780 2296 110485184
Cough 76.16 9.76 703 101116 460938 110026542
Hypocalcaemia 72.04 9.76 175 101644 65191 110422289
Secondary immunodeficiency 69.66 9.76 47 101772 4629 110482851
Irritable bowel syndrome 69.57 9.76 32 101787 164183 110323297
Monoparesis 68.39 9.76 46 101773 4507 110482973
Lung diffusion test decreased 66.77 9.76 32 101787 1633 110485847
Bursitis 65.71 9.76 19 101800 129899 110357581
Peripheral venous disease 64.72 9.76 3 101816 84114 110403366
Pulmonary mass 63.26 9.76 119 101700 37182 110450298
Exposure during pregnancy 63.00 9.76 38 101781 167386 110320094
Parathyroid gland enlargement 62.97 9.76 18 101801 202 110487278
Erythema multiforme 62.89 9.76 87 101732 21010 110466470
Hepatic steatosis 61.77 9.76 138 101681 48693 110438787
Nasal disorder 61.75 9.76 42 101777 4192 110483288
General physical health deterioration 61.51 9.76 194 101625 425101 110062379
Product dose omission issue 60.98 9.76 128 101691 321654 110165826
Discomfort 60.47 9.76 65 101754 214642 110272838
Blood pressure fluctuation 59.92 9.76 178 101641 74646 110412834
Upper-airway cough syndrome 59.11 9.76 73 101746 15784 110471696
Migraine with aura 59.07 9.76 38 101781 3454 110484026
Liver injury 56.79 9.76 34 101785 150379 110337101
Gastric polyps 56.04 9.76 44 101775 5479 110482001
Psoriatic arthropathy 54.93 9.76 60 101759 196701 110290779
Heart rate increased 54.87 9.76 270 101549 143564 110343916
Tonsillar disorder 54.84 9.76 27 101792 1462 110486018
Product use in unapproved indication 54.74 9.76 219 101600 447158 110040322
Tetanus 51.31 9.76 12 101807 55 110487425
Upper respiratory fungal infection 51.23 9.76 18 101801 409 110487071
Wound infection 50.86 9.76 13 101806 96452 110391028
Haemolysis 50.43 9.76 67 101752 15572 110471908
Drug ineffective for unapproved indication 49.66 9.76 207 101612 102631 110384849
Hepatic cancer 49.26 9.76 56 101763 11100 110476380
Renal impairment 48.88 9.76 319 101500 188126 110299354
Lichen sclerosus 48.52 9.76 23 101796 1145 110486335
Enterocolitis haemorrhagic 48.20 9.76 30 101789 2574 110484906
Impaired healing 47.55 9.76 67 101752 196650 110290830
Blood pressure systolic increased 47.31 9.76 176 101643 82815 110404665
Movement disorder 47.31 9.76 104 101715 36300 110451180
Colitis microscopic 47.27 9.76 60 101759 13334 110474146
Blister 46.91 9.76 86 101733 227290 110260190
Gastrooesophageal reflux disease 46.88 9.76 305 101514 179671 110307809
Forced expiratory volume 45.51 9.76 12 101807 97 110487383
Oral discomfort 45.30 9.76 54 101765 11257 110476223
Type 2 diabetes mellitus 45.24 9.76 58 101761 177174 110310306
Cestode infection 44.81 9.76 15 101804 293 110487187
Nocturia 44.67 9.76 66 101753 16924 110470556
Gait inability 43.39 9.76 37 101782 136339 110351141
Erectile dysfunction 43.03 9.76 68 101751 18488 110468992
Neutrophil count decreased 42.59 9.76 222 101597 120719 110366761
Mobility decreased 42.05 9.76 98 101721 237324 110250156
Nipple inflammation 42.04 9.76 10 101809 50 110487430
Malaise 41.93 9.76 859 100960 670960 109816520
Hypoparathyroidism secondary 41.75 9.76 14 101805 275 110487205
Cardiac failure congestive 41.24 9.76 259 101560 150741 110336739
Autoimmune disorder 40.46 9.76 6 101813 65477 110422003
Prescribed overdose 40.43 9.76 15 101804 87566 110399914
Tubulointerstitial nephritis 39.60 9.76 125 101694 54159 110433321
Blood pressure diastolic decreased 39.46 9.76 96 101723 35789 110451691
Adverse event 39.14 9.76 26 101793 108783 110378697
Cholecystitis chronic 39.11 9.76 46 101773 9454 110478026
Fibromyalgia 38.60 9.76 61 101758 170848 110316632
Sleep disorder 38.48 9.76 78 101741 198566 110288914
Grip strength decreased 38.26 9.76 13 101806 80161 110407319
Hepatocellular carcinoma 37.66 9.76 46 101773 9834 110477646
Injury 37.50 9.76 66 101753 177199 110310281
Polyp 37.29 9.76 46 101773 9934 110477546
Obesity 36.99 9.76 30 101789 113321 110374159
Therapy non-responder 36.62 9.76 55 101764 157252 110330228
Hypokalaemia 36.40 9.76 290 101529 182158 110305322
Hiatus hernia 36.02 9.76 79 101740 27527 110459953
Hepatic encephalopathy 35.90 9.76 80 101739 28176 110459304
Myocardial infarction 35.47 9.76 300 101519 191783 110295697
Intentional overdose 35.24 9.76 42 101777 132459 110355021
Headache 34.97 9.76 1061 100758 881316 109606164
Premenstrual syndrome 34.93 9.76 15 101804 591 110486889
Polymyalgia rheumatica 34.86 9.76 36 101783 6406 110481074
Mycobacterium test positive 34.12 9.76 15 101804 626 110486854
Oesophageal pain 33.98 9.76 32 101787 5093 110482387
Blepharospasm 33.95 9.76 5 101814 54846 110432634
Clumsiness 33.87 9.76 28 101791 3752 110483728
Anorectal discomfort 33.75 9.76 29 101790 4097 110483383
Constipation 33.72 9.76 489 101330 357297 110130183
Sputum culture 33.00 9.76 12 101807 302 110487178
Intentional product misuse 32.38 9.76 45 101774 132859 110354621
Chest discomfort 32.35 9.76 272 101547 173576 110313904
Macule 32.22 9.76 27 101792 3686 110483794
Occupational dermatitis 32.14 9.76 10 101809 153 110487327
Renal cyst 32.10 9.76 59 101760 18113 110469367
Sedation 32.05 9.76 12 101807 69671 110417809
Central nervous system lesion 32.01 9.76 54 101765 15499 110471981
Uveitis 31.65 9.76 65 101754 21645 110465835
Hypergastrinaemia 31.53 9.76 12 101807 344 110487136
Gastrointestinal motility disorder 31.24 9.76 36 101783 7240 110480240
Magnesium deficiency 31.22 9.76 15 101804 770 110486710
Abdominal mass 31.14 9.76 30 101789 4911 110482569
Iron deficiency anaemia 31.11 9.76 81 101738 31478 110456002
Night sweats 31.03 9.76 47 101772 133936 110353544
Fall 30.80 9.76 750 101069 602732 109884748
Mucosal inflammation 30.68 9.76 26 101793 96115 110391365
Nerve degeneration 30.32 9.76 11 101808 275 110487205
Blood iron increased 30.16 9.76 21 101798 2177 110485303
Product substitution issue 30.10 9.76 66 101753 22995 110464485
Balance disorder 30.02 9.76 197 101622 116363 110371117
Tubulointerstitial nephritis and uveitis syndrome 30.00 9.76 12 101807 394 110487086
Heart rate decreased 29.89 9.76 153 101666 82603 110404877
Rheumatoid arthritis 29.62 9.76 413 101406 299200 110188280
Liver disorder 29.42 9.76 228 101591 142015 110345465
Hypoparathyroidism 29.27 9.76 18 101801 1512 110485968
Confusional state 29.24 9.76 283 101536 468397 110019083
Red blood cell sedimentation rate increased 29.13 9.76 18 101801 78284 110409196
Coeliac disease 29.02 9.76 3 101816 43184 110444296
Pneumothorax spontaneous 28.84 9.76 19 101800 1798 110485682
Blood pressure decreased 28.72 9.76 193 101626 114898 110372582
Epilepsy 28.58 9.76 30 101789 100179 110387301
Fatigue 28.45 9.76 878 100941 1215080 109272400
Micturition urgency 28.35 9.76 58 101761 19262 110468218
Intentional product use issue 28.04 9.76 125 101694 247781 110239699
Blood pressure systolic abnormal 27.88 9.76 67 101752 24783 110462697
Stomatitis 27.79 9.76 141 101678 270101 110217379
Swelling 27.77 9.76 199 101620 350842 110136638
Lip infection 27.47 9.76 9 101810 164 110487316
Arthropathy 27.36 9.76 154 101665 287368 110200112
Malignant polyp 27.22 9.76 9 101810 169 110487311
Abdominal distension 26.98 9.76 263 101556 174840 110312640
Nail disorder 26.61 9.76 10 101809 57925 110429555
Gastric cancer 26.44 9.76 41 101778 10967 110476513
Gastric disorder 26.36 9.76 79 101740 33278 110454202
Medication error 26.35 9.76 35 101784 105331 110382149
No adverse event 26.08 9.76 18 101801 73821 110413659
White blood cell count decreased 25.92 9.76 324 101495 229066 110258414
Polymenorrhoea 25.90 9.76 15 101804 1129 110486351
Pneumonia 25.86 9.76 1019 100800 875695 109611785
Dyslalia 25.62 9.76 16 101803 1381 110486099
Spinal compression fracture 25.56 9.76 54 101765 18338 110469142
Neutrophilia 25.55 9.76 39 101780 10290 110477190
Knee arthroplasty 25.48 9.76 14 101805 64934 110422546
Hyperuricaemia 25.44 9.76 47 101772 14484 110472996
Fluid replacement 25.38 9.76 14 101805 959 110486521
Pulmonary function test abnormal 25.37 9.76 27 101792 4973 110482507
Condition aggravated 25.20 9.76 501 101318 734335 109753145
Infection 25.06 9.76 213 101606 361987 110125493
Hip arthroplasty 25.03 9.76 10 101809 55803 110431677
Sciatica 24.88 9.76 29 101790 92370 110395110
Chronic kidney disease 24.79 9.76 137 101682 76154 110411326
Disseminated intravascular coagulation 24.74 9.76 89 101730 41197 110446283
Upper respiratory tract inflammation 24.69 9.76 25 101794 4346 110483134
Productive cough 24.63 9.76 185 101634 114120 110373360
Overdose 24.60 9.76 121 101698 233673 110253807
Cardiac failure chronic 24.59 9.76 45 101774 13766 110473714
Product quality issue 24.55 9.76 21 101798 77278 110410202
Muscular dystrophy 24.30 9.76 9 101810 239 110487241
Hypereosinophilic syndrome 24.26 9.76 13 101806 841 110486639
Anaemia 24.13 9.76 667 101152 546419 109941061
Medication overuse headache 23.98 9.76 16 101803 1547 110485933
Biliary dyskinesia 23.95 9.76 19 101800 2402 110485078
Peripheral swelling 23.93 9.76 247 101572 403787 110083693
Lip pruritus 23.89 9.76 15 101804 1307 110486173
Decreased appetite 23.84 9.76 590 101229 475256 110012224
Ill-defined disorder 23.75 9.76 70 101749 156783 110330697
Bronchial disorder 23.70 9.76 20 101799 2756 110484724
Idiopathic pulmonary fibrosis 23.60 9.76 26 101793 4978 110482502
Nipple disorder 23.55 9.76 10 101809 383 110487097
Occupational exposure to air contaminants 23.54 9.76 8 101811 164 110487316
Enteritis infectious 23.40 9.76 23 101796 3859 110483621
Adenocarcinoma 23.30 9.76 24 101795 4256 110483224
Oxygen saturation decreased 22.84 9.76 233 101586 156749 110330731
Interstitial granulomatous dermatitis 22.81 9.76 9 101810 285 110487195
Ataxia 22.57 9.76 70 101749 30038 110457442
Barotrauma 22.44 9.76 8 101811 190 110487290
Primary hypoparathyroidism 22.38 9.76 6 101813 52 110487428
Pancreatic abscess 22.32 9.76 8 101811 193 110487287
Breast pain 22.30 9.76 36 101783 9964 110477516
Aortic dissection 22.18 9.76 25 101794 4908 110482572
Blood alkaline phosphatase increased 22.13 9.76 126 101693 70809 110416671
Incorrect route of product administration 22.12 9.76 16 101803 64045 110423435
Menstruation delayed 21.99 9.76 16 101803 1778 110485702
Road traffic accident 21.80 9.76 41 101778 107357 110380123
Joint range of motion decreased 21.79 9.76 50 101769 121782 110365698
Product use issue 21.70 9.76 183 101636 311512 110175968
Hepatotoxicity 21.67 9.76 16 101803 63384 110424096
Neutropenia 21.37 9.76 231 101588 374389 110113091
Vitamin D abnormal 21.13 9.76 8 101811 226 110487254
Renal disorder 21.13 9.76 96 101723 49383 110438097
Weight decreased 21.01 9.76 572 101247 467485 110019995
Retinal toxicity 20.80 9.76 15 101804 1644 110485836
Flatulence 20.67 9.76 99 101720 52050 110435430
Muscle strain 20.58 9.76 37 101782 11165 110476315
Dyspnoea exertional 20.53 9.76 165 101654 103895 110383585
Dysarthria 20.35 9.76 140 101679 83981 110403499
Respiratory tract infection 20.27 9.76 124 101695 71493 110415987
Carotid arteriosclerosis 20.10 9.76 19 101800 3038 110484442
Pigmentation disorder 20.09 9.76 29 101790 7282 110480198
Intra-abdominal fluid collection 20.07 9.76 21 101798 3793 110483687
Neurotoxicity 19.87 9.76 7 101812 42200 110445280
Gallbladder disorder 19.74 9.76 53 101766 20976 110466504
Dermatitis acneiform 19.69 9.76 39 101780 12656 110474824
Gastrointestinal polyp haemorrhage 19.67 9.76 11 101808 774 110486706
Cataract 19.65 9.76 133 101686 79352 110408128
Respiratory depression 19.61 9.76 3 101816 31998 110455482
Radioallergosorbent test positive 19.47 9.76 5 101814 36 110487444
Disease progression 19.45 9.76 138 101681 243896 110243584
Limb mass 19.38 9.76 21 101798 3948 110483532
Asthma 19.35 9.76 331 101488 249960 110237520
Haemochromatosis 19.34 9.76 14 101805 1543 110485937
Multiple organ dysfunction syndrome 19.33 9.76 73 101746 151637 110335843
Dyschromatopsia 19.26 9.76 13 101806 1281 110486199
Colon cancer 19.17 9.76 45 101774 16398 110471082
Acute myocardial infarction 18.85 9.76 137 101682 83640 110403840
Suicide attempt 18.84 9.76 42 101777 103352 110384128
Pneumonia bacterial 18.72 9.76 60 101759 26201 110461279
Clitoris abscess 18.69 9.76 4 101815 11 110487469
Pregnancy 18.64 9.76 12 101807 51055 110436425
Gamma-glutamyltransferase increased 18.53 9.76 108 101711 61201 110426279
Body temperature fluctuation 18.49 9.76 20 101799 3753 110483727
Premature delivery 18.48 9.76 3 101816 30629 110456851
Cholangitis 18.28 9.76 44 101775 16291 110471189
Injection site reaction 18.08 9.76 34 101785 89036 110398444
Joint swelling 17.98 9.76 293 101526 442552 110044928
Tibia fracture 17.92 9.76 26 101793 6559 110480921
Haemoglobin decreased 17.83 9.76 325 101494 248402 110239078
Duodenal polyp 17.80 9.76 9 101810 516 110486964
Pneumonia aspiration 17.80 9.76 132 101687 81101 110406379
Rubber sensitivity 17.78 9.76 16 101803 2402 110485078
IIIrd nerve paresis 17.67 9.76 7 101812 224 110487256
Mycobacterial infection 17.54 9.76 21 101798 4396 110483084
Forced expiratory volume decreased 17.52 9.76 38 101781 13138 110474342
Blood lactate dehydrogenase increased 17.45 9.76 84 101735 44250 110443230
Off label use 17.43 9.76 1169 100650 1499016 108988464
Intervertebral disc degeneration 17.40 9.76 46 101773 18039 110469441
Polyglandular disorder 17.24 9.76 7 101812 239 110487241
Poisoning 17.23 9.76 3 101816 29102 110458378
Dermatitis contact 17.16 9.76 39 101780 13914 110473566
Multiple fractures 17.03 9.76 30 101789 8910 110478570
Somnambulism 17.01 9.76 25 101794 6380 110481100
Adverse drug reaction 16.79 9.76 46 101773 105513 110381967
Spondyloarthropathy 16.68 9.76 13 101806 1601 110485879
Stress at work 16.65 9.76 12 101807 1313 110486167
Diverticulitis 16.65 9.76 95 101724 53427 110434053
Hospitalisation 16.62 9.76 71 101748 142422 110345058
Accidental exposure to product 16.61 9.76 13 101806 49995 110437485
Nephrectomy 16.58 9.76 16 101803 2624 110484856
Coronary artery disease 16.57 9.76 118 101701 71572 110415908
Thrombocytopenia 16.52 9.76 224 101595 348661 110138819
Rhinitis 16.52 9.76 52 101767 22493 110464987
Exostosis 16.50 9.76 11 101808 45945 110441535
Thalamus haemorrhage 16.46 9.76 14 101805 1950 110485530
Helicobacter test positive 16.43 9.76 12 101807 1341 110486139
Erosive oesophagitis 16.33 9.76 17 101802 3052 110484428
Hepatic cytolysis 16.24 9.76 16 101803 55037 110432443
Product prescribing error 16.23 9.76 14 101805 51317 110436163
Taste disorder 16.06 9.76 22 101797 65365 110422115
Blood cholesterol increased 15.97 9.76 102 101717 184683 110302797
Neck injury 15.88 9.76 17 101802 3151 110484329
Melaena 15.79 9.76 113 101706 68644 110418836
Rubella 15.73 9.76 6 101813 173 110487307
Measles 15.73 9.76 9 101810 662 110486818
Aphthous ulcer 15.71 9.76 49 101770 21087 110466393
Gastric dysplasia 15.67 9.76 4 101815 28 110487452
Oesophageal varices haemorrhage 15.66 9.76 21 101798 4924 110482556
Renal mass 15.63 9.76 18 101801 3617 110483863
Arthralgia 15.61 9.76 872 100947 778760 109708720
QRS axis abnormal 15.58 9.76 15 101804 2453 110485027
Onychomycosis 15.56 9.76 8 101811 38523 110448957
Ear infection 15.52 9.76 21 101798 62711 110424769
Abdominal pain upper 15.47 9.76 426 101393 348685 110138795
Immune-mediated enterocolitis 15.45 9.76 31 101788 10154 110477326
Haemorrhagic cerebral infarction 15.36 9.76 12 101807 1483 110485997
Anaemia folate deficiency 15.36 9.76 9 101810 692 110486788
Posterior reversible encephalopathy syndrome 15.29 9.76 6 101813 33855 110453625
Vulvovaginal pruritus 15.18 9.76 17 101802 3314 110484166
Head injury 15.16 9.76 79 101740 42938 110444542
Blood creatine phosphokinase increased 15.03 9.76 117 101702 72960 110414520
Cytokine release syndrome 15.02 9.76 26 101793 70280 110417200
Angina unstable 15.01 9.76 41 101778 16391 110471089
Muscle spasms 14.88 9.76 174 101645 277983 110209497
Emphysema 14.87 9.76 46 101773 19710 110467770
Finger deformity 14.72 9.76 6 101813 33086 110454394
Gallbladder injury 14.69 9.76 11 101808 1277 110486203
Nerve compression 14.68 9.76 32 101787 11105 110476375
Lower respiratory tract congestion 14.63 9.76 20 101799 4776 110482704
Therapy partial responder 14.52 9.76 8 101811 37053 110450427
Serotonin syndrome 14.43 9.76 20 101799 59133 110428347
Metamorphopsia 14.43 9.76 12 101807 1621 110485859
Hyponatraemia 14.42 9.76 281 101538 217372 110270108
Aspartate aminotransferase increased 14.42 9.76 217 101602 159719 110327761
Sleep attacks 14.25 9.76 6 101813 225 110487255
Bone erosion 14.24 9.76 13 101806 46358 110441122
Benign prostatic hyperplasia 14.23 9.76 43 101776 18191 110469289
Device issue 14.21 9.76 7 101812 34528 110452952
Red cell distribution width increased 14.21 9.76 42 101777 17560 110469920
Unresponsive to stimuli 14.18 9.76 23 101796 63767 110423713
Concomitant disease aggravated 14.13 9.76 40 101779 16324 110471156
Pollakiuria 14.11 9.76 79 101740 44116 110443364
Somnolence 14.07 9.76 191 101628 297258 110190222
Injection site swelling 13.99 9.76 22 101797 61768 110425712
Injection site pain 13.99 9.76 101 101718 177821 110309659
Eosinophil count decreased 13.88 9.76 22 101797 5996 110481484
Respiratory fume inhalation disorder 13.86 9.76 6 101813 241 110487239
Haemorrhage subcutaneous 13.82 9.76 21 101798 5518 110481962
Mental status changes 13.81 9.76 31 101788 76091 110411389
Joint injury 13.79 9.76 73 101746 39921 110447559
Liver function test increased 13.78 9.76 39 101780 88509 110398971
Hypotension 13.76 9.76 372 101447 523477 109964003
Compression fracture 13.74 9.76 28 101791 9271 110478209
Pulmonary fibrosis 13.73 9.76 48 101771 101994 110385486
Device dislocation 13.70 9.76 6 101813 31698 110455782
Liver abscess 13.51 9.76 25 101794 7714 110479766
Granuloma 13.35 9.76 28 101791 9462 110478018
Ankylosing spondylitis 13.32 9.76 38 101781 15574 110471906
Therapy cessation 13.28 9.76 13 101806 44844 110442636
Delusion of replacement 13.23 9.76 6 101813 270 110487210
Bile duct stone 13.16 9.76 22 101797 6267 110481213
Tooth disorder 13.16 9.76 58 101761 29451 110458029
Liver iron concentration abnormal 13.06 9.76 4 101815 58 110487422
Therapy interrupted 13.02 9.76 16 101803 49806 110437674
Oral discharge 13.02 9.76 6 101813 280 110487200
Neutropenic sepsis 13.00 9.76 6 101813 30740 110456740
Blood gastrin increased 12.81 9.76 4 101815 62 110487418
Hepatitis chronic active 12.80 9.76 6 101813 291 110487189
Pneumonitis 12.80 9.76 117 101702 76414 110411066
Sitting disability 12.79 9.76 7 101812 472 110487008
Hepatic enzyme increased 12.79 9.76 213 101606 320679 110166801
Alanine aminotransferase increased 12.77 9.76 239 101580 183534 110303946
Blood bilirubin increased 12.64 9.76 116 101703 75856 110411624
Q fever 12.62 9.76 6 101813 301 110487179
Bronchiolitis 12.56 9.76 20 101799 5473 110482007
Embolic stroke 12.54 9.76 26 101793 8717 110478763
Tetany 12.49 9.76 16 101803 3588 110483892
Diverticulum 12.49 9.76 37 101782 15489 110471991
Coeliac artery occlusion 12.45 9.76 3 101816 16 110487464
Blood urea increased 12.44 9.76 90 101729 54867 110432613
Communication disorder 12.43 9.76 19 101800 5020 110482460
Myalgia 12.42 9.76 280 101539 222101 110265379
Fulminant type 1 diabetes mellitus 12.42 9.76 13 101806 2350 110485130
Enterocolitis 12.35 9.76 42 101777 18907 110468573
Intensive care 12.34 9.76 13 101806 2366 110485114
Abdominal tenderness 12.31 9.76 32 101787 12425 110475055
Ear discomfort 12.27 9.76 30 101789 11219 110476261
Bed bug infestation 12.25 9.76 4 101815 72 110487408
Injection site erythema 12.20 9.76 45 101774 94131 110393349
Adverse reaction 12.17 9.76 6 101813 29588 110457892
Sinusitis 12.13 9.76 196 101623 296492 110190988
Pancreatitis acute 12.12 9.76 96 101723 60178 110427302
Contusion 12.09 9.76 147 101672 233214 110254266
Musculoskeletal stiffness 12.07 9.76 183 101636 279639 110207841
Tachycardia 12.03 9.76 142 101677 226503 110260977
Chorioretinal disorder 12.02 9.76 5 101814 182 110487298
Skin haemorrhage 11.89 9.76 4 101815 24823 110462657
Hypozincaemia 11.86 9.76 4 101815 80 110487400
Inappropriate antidiuretic hormone secretion 11.81 9.76 62 101757 33789 110453691
Therapeutic reaction time decreased 11.77 9.76 19 101800 5260 110482220
Eye contusion 11.74 9.76 14 101805 2918 110484562
Poor venous access 11.55 9.76 49 101770 24473 110463007
Lower respiratory tract infection viral 11.53 9.76 10 101809 1431 110486049
Hypoalbuminaemia 11.48 9.76 55 101764 28919 110458561
Occupational exposure to product 11.47 9.76 8 101811 831 110486649
Vocal cord paralysis 11.46 9.76 14 101805 2992 110484488
Hypertransaminasaemia 11.45 9.76 4 101815 24251 110463229
Diarrhoea 11.45 9.76 1207 100612 1138298 109349182
Blood albumin decreased 11.32 9.76 53 101766 27599 110459881
Middle insomnia 11.28 9.76 43 101776 20459 110467021
Postmenopausal haemorrhage 11.24 9.76 11 101808 1835 110485645
Gastroenteritis eosinophilic 11.24 9.76 6 101813 385 110487095
Psoriasis 11.23 9.76 79 101740 139914 110347566
Accidental overdose 11.23 9.76 19 101800 51815 110435665
Disability 11.17 9.76 7 101812 30216 110457264
Osteonecrosis of jaw 11.08 9.76 79 101740 47938 110439542
Cystitis 11.07 9.76 101 101718 65935 110421545
Gastric antral vascular ectasia 11.00 9.76 9 101810 1188 110486292
Hyperventilation 10.99 9.76 25 101794 8922 110478558
Catheter site hypersensitivity 10.91 9.76 4 101815 103 110487377
Cholangitis acute 10.91 9.76 11 101808 1902 110485578
Muscular weakness 10.88 9.76 162 101657 248306 110239174
Lower respiratory tract infection 10.82 9.76 158 101661 242948 110244532
Intramedullary rod insertion 10.82 9.76 5 101814 235 110487245
Device malfunction 10.79 9.76 5 101814 25553 110461927
Pancreatic neuroendocrine tumour 10.79 9.76 8 101811 915 110486565
Carcinoid tumour pulmonary 10.79 9.76 6 101813 418 110487062
Lupus-like syndrome 10.77 9.76 13 101806 40779 110446701
Microcytic anaemia 10.74 9.76 20 101799 6198 110481282
Gastric ulcer 10.67 9.76 68 101751 39759 110447721
Jaundice 10.65 9.76 92 101727 59144 110428336
Nephroangiosclerosis 10.62 9.76 6 101813 431 110487049
Rib fracture 10.54 9.76 60 101759 33710 110453770
Bronchitis 10.49 9.76 203 101616 156829 110330651
Lung neoplasm malignant 10.48 9.76 60 101759 33782 110453698
Carotid artery stenosis 10.42 9.76 25 101794 9238 110478242
Diabetic neuropathy 10.25 9.76 21 101798 6978 110480502
Gastroenteritis 10.24 9.76 66 101753 38734 110448746
Colon cancer stage II 10.20 9.76 5 101814 268 110487212
Nail infection 10.16 9.76 12 101807 2476 110485004
Blood glucose increased 10.15 9.76 175 101644 132321 110355159
Cholelithiasis 10.13 9.76 96 101723 63326 110424154
Altered state of consciousness 10.10 9.76 89 101730 57537 110429943
Muscle spasticity 10.04 9.76 62 101757 35853 110451627
Nausea 10.01 9.76 1291 100528 1234399 109253081
Erythema of eyelid 9.99 9.76 15 101804 3900 110483580
Tendon disorder 9.92 9.76 23 101796 8314 110479166
Mydriasis 9.88 9.76 4 101815 22153 110465327
Pleurisy 9.86 9.76 29 101790 12087 110475393
Anticoagulation drug level decreased 9.85 9.76 5 101814 289 110487191
Blood pressure systolic decreased 9.84 9.76 31 101788 13410 110474070
Pyomyositis 9.82 9.76 7 101812 753 110486727
Hepatitis 9.82 9.76 46 101773 90008 110397472
Polyneuropathy 9.80 9.76 9 101810 32003 110455477
Osmophobia 9.79 9.76 4 101815 139 110487341

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BC04 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Proton pump inhibitors
ATC A02BC54 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Proton pump inhibitors
ATC A02BD12 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
ATC A02BD13 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
FDA MoA N0000000147 Proton Pump Inhibitors
FDA EPC N0000175525 Proton Pump Inhibitor
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:49200 EC 3.6.3.10 (<em>H</em><small><sup>+</small></sup>/<em>K</em><small><sup>+</small></sup>-exchanging ATPase) inhibitor
CHEBI has role CHEBI:49201 anti-ulcer drug
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054328 Proton Pump Inhibitors

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A02BD Combinations for eradication of Helicobacter pylori 13 drugs
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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Duodenal ulcer disease indication 51868009 DOID:1724
Zollinger-Ellison syndrome indication 53132006 DOID:0050782
Multiple endocrine adenomas indication 60549007
Gastroesophageal reflux disease indication 235595009 DOID:8534
Systemic mast cell disease indication 397016004 DOID:349
Duodenal Ulcer due to H. Pylori indication
Maintenance of Healing Gastroesophageal Reflux indication
Pathological Gastric Hypersecretory Condition indication
Upper gastrointestinal hemorrhage off-label use 37372002
Prevention of NSAID-Induced Gastric Ulcer off-label use
Osteoporosis contraindication 64859006 DOID:11476
Fracture of bone contraindication 125605004
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.23 acidic
pKa2 3.9 Basic
pKa3 2.72 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Potassium-transporting ATPase Transporter INHIBITOR CHEMBL CHEMBL
D(3) dopamine receptor GPCR Ki 6.10 DRUG MATRIX
5-hydroxytryptamine receptor 1D GPCR Ki 5.12 WOMBAT-PK
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter WOMBAT-PK
Adenosine receptor A3 GPCR Ki 5.74 DRUG MATRIX
ATP-binding cassette sub-family G member 2 Transporter IC50 5.07 CHEMBL
Fatty acid synthase Enzyme Ki 5.23 CHEMBL
Insulin-degrading enzyme Enzyme IC50 4.96 CHEMBL
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Enzyme IC50 4.28 CHEMBL
Cytosolic endo-beta-N-acetylglucosaminidase Enzyme IC50 5.35 CHEMBL
Alpha-2B adrenergic receptor GPCR Ki 6.10 DRUG MATRIX
Sterile alpha and TIR motif-containing protein 1 Enzyme IC50 5.50 CHEMBL

External reference:

IDSource
4021174 VUID
N0000148623 NUI
D00724 KEGG_DRUG
117976-90-6 SECONDARY_CAS_RN
4021174 VANDF
4021175 VANDF
C0378482 UMLSCUI
CHEBI:8768 CHEBI
RZX PDB_CHEM_ID
CHEMBL1219 ChEMBL_ID
CHEMBL1200930 ChEMBL_ID
DB01129 DRUGBANK_ID
D064750 MESH_DESCRIPTOR_UI
5029 PUBCHEM_CID
7290 IUPHAR_LIGAND_ID
7112 INN_ID
32828355LL UNII
114979 RXNORM
206957 MMSL
31277 MMSL
8292 MMSL
d04448 MMSL
007680 NDDF
007681 NDDF
387013009 SNOMEDCT_US
421279008 SNOMEDCT_US
422225001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Rabeprazole sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-107 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
Rabeprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 45865-123 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
RABEPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 45865-802 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
RABEPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 50090-1424 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
Rabeprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 50090-3145 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 29 sections
Rabeprazole sodium HUMAN PRESCRIPTION DRUG LABEL 1 50090-3182 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 29 sections
Rabeprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 50090-3430 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 30 sections
Rabeprazole Sodium Human Prescription Drug Label 1 50090-4751 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 28 sections
RABEPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 50090-6887 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
Rabeprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 50436-0302 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 28 sections
Rabeprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 50436-0724 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 20 sections
Rabeprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 51407-184 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 28 sections
Aciphex HUMAN PRESCRIPTION DRUG LABEL 1 54868-4185 TABLET, DELAYED RELEASE 20 mg ORAL NDA 28 sections
Rabeprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 60760-560 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
Rabeprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 60760-560 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
RABEPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 60760-972 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 26 sections
RABERPRAZOLE SODIUM D/R HUMAN PRESCRIPTION DRUG LABEL 1 61919-225 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 17 sections
RABEPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 61919-467 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 17 sections
Rabeprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 62135-503 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 20 sections
Rabeprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 62175-302 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 28 sections
AcipHex HUMAN PRESCRIPTION DRUG LABEL 1 62856-243 TABLET, DELAYED RELEASE 20 mg ORAL NDA 31 sections
Rabeprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 63187-259 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 31 sections
Rabeprazole sodium HUMAN PRESCRIPTION DRUG LABEL 1 63187-555 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
Rabeprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 65162-724 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 19 sections
Rabeprazole Sodium Human Prescription Drug Label 1 65862-721 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
Rabeprazole Sodium Human Prescription Drug Label 1 67877-443 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
AcipHex HUMAN PRESCRIPTION DRUG LABEL 1 68151-3834 TABLET, DELAYED RELEASE 20 mg ORAL NDA 29 sections
Rabeprazole sodium HUMAN PRESCRIPTION DRUG LABEL 1 68788-4060 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
Rabeprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 68788-7459 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
RABEPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 68788-8536 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections