pantoprazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antiulcer, benzimidazole derivatives 2054 102625-70-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pantoprazole
  • pantozol
  • pantoprazole sodium
  • controloc control
  • pantoprazole sodium hydrate
  • pantoprazole sodium sesquihydrate
Pantoprazole sodium is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by covalently binding to the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus. The binding to the (H+, K+)-ATPase results in a duration of antisecretory effect that persists longer than 24 hours.
  • Molecular weight: 383.37
  • Formula: C16H15F2N3O4S
  • CLOGP: 2.11
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 86.33
  • ALOGS: -2.89
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O
40 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.74 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.20 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.90 hours Lombardo F, Berellini G, Obach RS
BA (Bioavailability) 78 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ZAP70 51
kinase-selectivity-class PDK4 1
pfas-class PFAS structural alert (1 = True, 0 = False) 1
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 0.86

Approvals:

DateAgencyCompanyOrphan
Feb. 2, 2000 FDA WYETH PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 665.19 9.75 943 799260 286903 89541341
General physical health deterioration 580.97 9.75 5224 794979 349891 89478353
Drug ineffective 541.93 9.75 8791 791412 1375507 88452737
Completed suicide 499.77 9.75 333 799870 144725 89683519
Chronic kidney disease 430.94 9.75 1192 799011 48999 89779245
Injection site reaction 314.94 9.75 213 799990 91867 89736377
Device expulsion 274.75 9.75 23 800180 40863 89787381
Haematochezia 271.77 9.75 1294 798909 69619 89758625
Death 244.49 9.75 2714 797489 453837 89374407
Rheumatoid arthritis 242.81 9.75 4524 795679 358090 89470154
Product prescribing error 228.81 9.75 685 799518 29460 89798784
Muscle injury 228.47 9.75 2476 797727 174178 89654066
Sleep disorder due to general medical condition, insomnia type 224.87 9.75 1922 798281 126772 89701472
Intentional overdose 222.91 9.75 301 799902 93533 89734711
Irritable bowel syndrome 205.06 9.75 2763 797440 204685 89623559
Off label use 204.98 9.75 7815 792388 1094437 88733807
Injection site pain 200.58 9.75 820 799383 172879 89655365
Hypomagnesaemia 199.68 9.75 730 799473 34858 89793386
Lower respiratory tract infection 199.28 9.75 3215 796988 247444 89580800
Abortion spontaneous 197.28 9.75 116 800087 53940 89774304
Hyponatraemia 194.63 9.75 1918 798285 131620 89696624
Drug abuse 192.74 9.75 267 799936 82080 89746164
Acute kidney injury 186.75 9.75 3915 796288 316472 89511772
Injection site erythema 185.37 9.75 368 799835 98134 89730110
Product dose omission issue 184.26 9.75 1666 798537 290021 89538223
Myelosuppression 183.20 9.75 124 800079 53467 89774777
Muscle spasticity 169.09 9.75 689 799514 34633 89793611
Anaemia 168.81 9.75 4193 796010 348609 89479635
Systemic infection 164.56 9.75 207 799996 4568 89823676
Disease progression 162.82 9.75 769 799434 155846 89672398
Impaired healing 162.56 9.75 2939 797264 231260 89596984
Exposure during pregnancy 161.54 9.75 1337 798866 237073 89591171
Folliculitis 148.03 9.75 2582 797621 201771 89626473
Stomatitis 147.32 9.75 3317 796886 271381 89556863
Abdominal pain upper 146.61 9.75 3911 796292 328763 89499481
Onychomycosis 142.45 9.75 76 800127 37300 89790944
Gastrointestinal disorder 142.21 9.75 3114 797089 253573 89574671
Sinusitis 141.19 9.75 3998 796205 339090 89489154
Renal injury 140.71 9.75 292 799911 9951 89818293
Peripheral swelling 140.25 9.75 4702 795501 408404 89419840
Hypokalaemia 129.34 9.75 1746 798457 129370 89698874
Drug resistance 126.60 9.75 55 800148 30394 89797850
Confusional state 123.82 9.75 4367 795836 381838 89446406
Labelled drug-drug interaction medication error 120.89 9.75 342 799861 14240 89814004
Product monitoring error 115.59 9.75 170 800033 4374 89823870
Sedation complication 115.32 9.75 9 800194 16935 89811309
Blister 114.92 9.75 3007 797196 251991 89576253
Abdominal pain 114.59 9.75 4424 795779 391297 89436947
Ill-defined disorder 112.76 9.75 2275 797928 182616 89645628
Wrong technique in product usage process 111.51 9.75 296 799907 71275 89756969
Hepatic function abnormal 111.43 9.75 147 800056 46141 89782103
Pyrexia 111.13 9.75 7002 793201 653483 89174761
End stage renal disease 110.39 9.75 238 799965 8333 89819911
Maternal exposure during pregnancy 109.93 9.75 2382 797821 357681 89470563
Premature delivery 107.43 9.75 110 800093 38652 89789592
Tubulointerstitial nephritis 107.10 9.75 476 799727 24867 89803377
Accidental exposure to product 106.71 9.75 130 800073 42236 89786008
No adverse event 103.03 9.75 285 799918 67697 89760547
Body temperature increased 102.76 9.75 712 799491 43998 89784246
Contusion 99.29 9.75 2913 797290 248303 89579941
Ear pain 99.28 9.75 859 799344 56843 89771401
Haematemesis 98.56 9.75 571 799632 33155 89795089
Neuropathy peripheral 97.38 9.75 758 799445 136212 89692032
Injection site pruritus 97.13 9.75 206 799997 53628 89774616
White blood cell count decreased 96.70 9.75 975 799228 166134 89662110
Injection site swelling 95.89 9.75 244 799959 59595 89768649
Sedation 94.95 9.75 175 800028 47996 89780248
Infection 93.25 9.75 3998 796205 358096 89470148
Dyspnoea 92.36 9.75 9001 791202 871954 88956290
Adverse reaction 90.97 9.75 77 800126 29635 89798609
Hypocalcaemia 90.57 9.75 663 799540 41705 89786539
Orthostatic intolerance 87.85 9.75 82 800121 1272 89826972
Foetal exposure during pregnancy 87.51 9.75 153 800050 42822 89785422
Asthenia 86.31 9.75 5640 794563 528111 89300133
Product label confusion 86.29 9.75 47 800156 22803 89805441
Overdose 85.61 9.75 934 799269 156775 89671469
Drug hypersensitivity 84.11 9.75 3294 796909 460315 89367929
Treatment failure 82.27 9.75 2048 798155 301880 89526364
Product use in unapproved indication 82.26 9.75 2299 797904 333937 89494307
Melaena 79.88 9.75 554 799649 34243 89794001
Finger deformity 78.65 9.75 105 800098 32792 89795452
Agranulocytosis 77.85 9.75 553 799650 34449 89793795
Seizure 77.32 9.75 918 799285 151711 89676533
Respiratory disorder 76.24 9.75 892 799311 63924 89764320
Drug dependence 75.99 9.75 88 800115 29239 89799005
Therapeutic product effect incomplete 71.53 9.75 1242 798961 192654 89635590
Night sweats 71.51 9.75 1563 798640 127203 89701041
Respiratory arrest 71.15 9.75 115 800088 33196 89795048
Intentional self-injury 70.77 9.75 93 800110 29241 89799003
Eosinophilia 70.12 9.75 462 799741 28071 89800173
Gastritis 69.45 9.75 617 799586 41136 89787108
Weight increased 67.46 9.75 4416 795787 413511 89414733
Anaphylactic reaction 67.16 9.75 474 799729 87050 89741194
Gastrointestinal haemorrhage 66.98 9.75 1145 799058 89103 89739141
Therapy partial responder 66.42 9.75 58 800145 21985 89806259
Subacute cutaneous lupus erythematosus 66.38 9.75 116 800087 3466 89824778
Platelet count decreased 65.15 9.75 835 799368 136134 89692110
Coma 65.13 9.75 375 799828 72257 89755987
Clostridium test positive 65.06 9.75 146 800057 5255 89822989
Onychomadesis 63.78 9.75 201 800002 45797 89782447
Device difficult to use 63.39 9.75 38 800165 17487 89810757
Neutrophil count decreased 63.25 9.75 371 799832 71161 89757083
Feeling abnormal 62.40 9.75 1069 799134 166166 89662078
Suicidal ideation 61.15 9.75 391 799812 73464 89754780
Balance disorder 60.55 9.75 556 799647 96524 89731720
Temperature regulation disorder 60.23 9.75 272 799931 14307 89813937
Neck pain 58.65 9.75 683 799520 113280 89714964
Food allergy 58.11 9.75 405 799798 25073 89803171
Irritability 57.46 9.75 145 800058 35517 89792727
Hypoparathyroidism secondary 56.81 9.75 21 800182 39 89828205
Colitis ulcerative 56.34 9.75 795 799408 59471 89768773
Cardio-respiratory arrest 56.08 9.75 327 799876 62813 89765431
Product storage error 55.46 9.75 58 800145 20183 89808061
Vision blurred 54.85 9.75 666 799537 109627 89718617
Device dislocation 54.70 9.75 123 800080 31359 89796885
Nasopharyngitis 54.70 9.75 4238 795965 402866 89425378
Flushing 54.68 9.75 508 799695 87983 89740261
Cholestasis 54.62 9.75 525 799678 35774 89792470
Therapeutic drug monitoring analysis not performed 54.62 9.75 63 800140 1266 89826978
Leukopenia 53.56 9.75 1215 798988 99495 89728749
Thrombocytopenia 53.08 9.75 2302 797901 206423 89621821
Cachexia 52.86 9.75 157 800046 6721 89821523
Faecaloma 52.75 9.75 207 799996 10224 89818020
Injection site bruising 51.35 9.75 262 799941 52045 89776199
Dystonia 50.99 9.75 44 800159 16775 89811469
Somnolence 50.22 9.75 1433 798770 207651 89620593
Asthma 49.96 9.75 2616 797587 239544 89588700
Rebound acid hypersecretion 49.76 9.75 34 800169 326 89827918
Therapeutic response decreased 49.64 9.75 529 799674 89200 89739044
Depressed level of consciousness 49.32 9.75 408 799795 72376 89755868
Post transplant lymphoproliferative disorder 49.30 9.75 3 800200 6946 89821298
Depression 49.10 9.75 2161 798042 298440 89529804
Caesarean section 48.94 9.75 55 800148 18522 89809722
Serotonin syndrome 48.79 9.75 171 800032 37716 89790528
Genital haemorrhage 48.54 9.75 9 800194 8693 89819551
Device issue 48.44 9.75 119 800084 29418 89798826
Lung diffusion test abnormal 48.13 9.75 32 800171 292 89827952
Angina pectoris 47.87 9.75 543 799660 38617 89789627
Hypertensive nephropathy 47.77 9.75 43 800160 635 89827609
Pruritus 46.59 9.75 5462 794741 536063 89292181
Injection site haemorrhage 46.51 9.75 114 800089 28204 89800040
Pre-eclampsia 45.86 9.75 20 800183 11028 89817216
Drug use disorder 45.75 9.75 9 800194 8334 89819910
Suicide attempt 45.66 9.75 435 799768 74964 89753280
Poisoning deliberate 45.44 9.75 47 800156 16439 89811805
Breast cancer 45.34 9.75 283 799920 53478 89774766
Drug ineffective for unapproved indication 44.96 9.75 374 799829 66270 89761974
Unintentional medical device removal 44.48 9.75 5 800198 7025 89821219
Electrolyte imbalance 44.30 9.75 360 799843 23385 89804859
Prescribed overdose 43.56 9.75 1150 799053 96475 89731769
Renal failure 43.53 9.75 1488 798715 129519 89698725
Mydriasis 43.45 9.75 41 800162 14971 89813273
Neutropenic sepsis 43.20 9.75 58 800145 18072 89810172
Injection site rash 43.19 9.75 93 800110 24080 89804164
Exposure to toxic agent 42.84 9.75 9 800194 7958 89820286
Cellulitis 42.62 9.75 559 799644 90778 89737466
Gestational diabetes 42.61 9.75 20 800183 10562 89817682
Blood loss anaemia 41.75 9.75 189 800014 9951 89818293
Malaise 41.58 9.75 4534 795669 581452 89246792
Injection site urticaria 41.53 9.75 59 800144 17952 89810292
Breast cancer female 41.53 9.75 42 800161 14844 89813400
Multiple-drug resistance 41.37 9.75 9 800194 7767 89820477
Clostridium difficile colitis 41.05 9.75 388 799815 26318 89801926
Nail disorder 40.98 9.75 329 799874 58738 89769506
Hypomania 40.41 9.75 14 800189 8883 89819361
Drug dose omission by device 40.18 9.75 20 800183 10211 89818033
Immunodeficiency 39.88 9.75 569 799634 42665 89785579
Obstructive airways disorder 39.84 9.75 376 799827 25493 89802751
Premature baby 39.60 9.75 103 800100 24974 89803270
Pulmonary fibrosis 39.58 9.75 1236 798967 106267 89721977
Dissociation 39.55 9.75 6 800197 6709 89821535
Cardiac arrest 39.05 9.75 671 799532 104264 89723980
Device malfunction 38.91 9.75 79 800124 20898 89807346
Dyspnoea exertional 38.71 9.75 873 799330 71415 89756829
Uterine perforation 37.72 9.75 10 800193 7544 89820700
Breast cancer stage I 37.52 9.75 19 800184 9605 89818639
Enthesopathy 37.52 9.75 18 800185 9386 89818858
Pneumonia viral 36.74 9.75 165 800038 8658 89819586
Device breakage 36.54 9.75 42 800161 14002 89814242
Surgery 36.46 9.75 239 799964 44648 89783596
Upper gastrointestinal haemorrhage 36.41 9.75 336 799867 22640 89805604
Creatinine renal clearance decreased 36.07 9.75 70 800133 18829 89809415
Mycotic allergy 36.06 9.75 46 800157 1030 89827214
Injection site warmth 35.99 9.75 62 800141 17453 89810791
Drug withdrawal syndrome 35.42 9.75 132 800071 28591 89799653
Liver injury 35.04 9.75 1842 798361 168725 89659519
Helicobacter infection 34.76 9.75 2387 797816 224463 89603781
Abdominal pain lower 34.47 9.75 413 799790 29764 89798480
Disseminated intravascular coagulation 34.37 9.75 88 800115 21450 89806794
Haematoma 34.08 9.75 509 799694 38539 89789705
Arterial occlusive disease 33.98 9.75 207 799996 12239 89816005
Musculoskeletal disorder 33.93 9.75 90 800113 21679 89806565
Hypertensive crisis 33.92 9.75 271 799932 17513 89810731
Substance abuse 33.82 9.75 4 800199 5402 89822842
Multiple sclerosis relapse 33.73 9.75 297 799906 52008 89776236
Pregnancy with contraceptive device 33.63 9.75 3 800200 5063 89823181
Alopecia 33.59 9.75 3842 796361 491229 89337015
Joint injury 33.56 9.75 161 800042 32503 89795741
Complication of device insertion 33.25 9.75 26 800177 10410 89817834
Treatment noncompliance 33.23 9.75 294 799909 51433 89776811
Dysphoria 32.99 9.75 7 800196 6147 89822097
Cytomegalovirus infection 32.97 9.75 122 800081 26480 89801764
Inappropriate antidiuretic hormone secretion 32.83 9.75 289 799914 19216 89809028
Premature rupture of membranes 32.66 9.75 5 800198 5553 89822691
Blood pressure systolic increased 32.62 9.75 709 799494 57636 89770608
Sickle cell anaemia with crisis 32.26 9.75 12 800191 7285 89820959
Soft tissue disorder 32.09 9.75 97 800106 4193 89824051
Blood calcium decreased 32.05 9.75 147 800056 30035 89798209
Gastric ulcer 31.94 9.75 377 799826 27071 89801173
Nasal obstruction 31.90 9.75 71 800132 2541 89825703
Hepatitis cholestatic 31.90 9.75 155 800048 8406 89819838
Vitamin B12 decreased 31.55 9.75 111 800092 5199 89823045
Total lung capacity decreased 31.45 9.75 89 800114 3706 89824538
Abnormal behaviour 31.29 9.75 99 800104 22529 89805715
Skin disorder 31.07 9.75 193 800010 36513 89791731
Trimethylaminuria 31.05 9.75 20 800183 172 89828072
Vaginal haemorrhage 31.05 9.75 156 800047 31115 89797129
Diverticulum intestinal 30.88 9.75 161 800042 8981 89819263
Iron deficiency anaemia 30.70 9.75 332 799871 23330 89804914
Hepatotoxicity 30.59 9.75 258 799945 45584 89782660
Pathogen resistance 30.20 9.75 17 800186 8098 89820146
Medication error 30.04 9.75 969 799234 83683 89744561
Dry skin 29.99 9.75 572 799631 87501 89740743
Cardiac failure 29.94 9.75 1217 798986 108279 89719965
Complication of device removal 29.90 9.75 9 800194 6246 89821998
Hepatic enzyme increased 29.71 9.75 3629 796574 357107 89471137
Urosepsis 29.48 9.75 302 799901 20930 89807314
Hypersensitivity 29.31 9.75 4508 795695 450169 89378075
Therapy interrupted 29.11 9.75 292 799911 49816 89778428
Hypoaesthesia 28.94 9.75 2384 797819 311826 89516418
Pancreatic steatosis 28.92 9.75 52 800151 1590 89826654
Unevaluable event 28.88 9.75 327 799876 54521 89773723
Nasal oedema 28.82 9.75 11 800192 6573 89821671
Congenital anomaly 28.81 9.75 10 800193 6337 89821907
Coagulation test abnormal 28.66 9.75 39 800164 932 89827312
Device use error 28.54 9.75 14 800189 7207 89821037
Febrile infection 28.44 9.75 59 800144 2010 89826234
Renal impairment 28.20 9.75 1169 799034 104252 89723992
Blood pressure diastolic abnormal 28.18 9.75 284 799919 19597 89808647
Duodenal ulcer perforation 28.10 9.75 2294 797909 218994 89609250
Hiatus hernia 28.06 9.75 345 799858 25016 89803228
Epstein-Barr virus infection 27.94 9.75 30 800173 10314 89817930
Hyperkinesia 27.89 9.75 56 800147 1863 89826381
Throat clearing 27.86 9.75 86 800117 3761 89824483
Paroxysmal extreme pain disorder 27.77 9.75 16 800187 110 89828134
Gastroenteritis clostridial 27.74 9.75 32 800171 643 89827601
Device deployment issue 27.55 9.75 5 800198 4904 89823340
Hepatic cyst 27.48 9.75 123 800080 6445 89821799
Dehydration 27.36 9.75 2032 798171 192415 89635829
Body temperature decreased 27.22 9.75 326 799877 23490 89804754
Musculoskeletal pain 26.94 9.75 1806 798397 169445 89658799
Gamma-glutamyltransferase increased 26.89 9.75 478 799725 37474 89790770
Malignant neoplasm progression 26.79 9.75 728 799475 106142 89722102
Duodenitis 26.61 9.75 92 800111 4271 89823973
Cerebral ischaemia 26.61 9.75 130 800073 7066 89821178
Pneumonia aspiration 26.61 9.75 232 799971 40708 89787536
Blood pressure systolic abnormal 26.54 9.75 276 799927 19202 89809042
Autoimmune disorder 26.33 9.75 875 799328 75869 89752375
Pain in jaw 26.09 9.75 284 799919 47701 89780543
Diabetic nephropathy 25.68 9.75 51 800152 1683 89826561
Drug reaction with eosinophilia and systemic symptoms 25.66 9.75 525 799678 42233 89786011
Spontaneous haemorrhage 25.62 9.75 32 800171 701 89827543
Heavy menstrual bleeding 25.55 9.75 94 800109 20436 89807808
Polycystic ovaries 25.50 9.75 9 800194 5645 89822599
Abortion induced 25.43 9.75 41 800162 11847 89816397
Back injury 25.32 9.75 276 799927 46346 89781898
Schizophrenia 25.32 9.75 59 800144 14855 89813389
Adenovirus infection 25.31 9.75 5 800198 4617 89823627
Painful respiration 25.23 9.75 71 800132 2947 89825297
Oesophagitis 25.23 9.75 248 799955 17001 89811243
Drug intolerance 25.22 9.75 3515 796688 444076 89384168
Frequent bowel movements 25.20 9.75 670 799533 56265 89771979
Urinary tract obstruction 25.11 9.75 59 800144 2190 89826054
X-ray abnormal 25.08 9.75 551 799652 44873 89783371
Oesophageal dilatation 25.04 9.75 27 800176 502 89827742
Psychotic disorder 25.01 9.75 167 800036 31063 89797181
Polyneuropathy 24.92 9.75 271 799932 19070 89809174
Bacteriuria 24.92 9.75 41 800162 1165 89827079
Product complaint 24.90 9.75 51 800152 13449 89814795
Eructation 24.83 9.75 173 800030 10709 89817535
Posterior reversible encephalopathy syndrome 24.81 9.75 107 800096 22232 89806012
Acute abdomen 24.73 9.75 49 800154 1614 89826630
Atrial fibrillation 24.70 9.75 1429 798774 132182 89696062
Incorrect dose administered 24.66 9.75 520 799683 78410 89749834
Drug eruption 24.66 9.75 197 800006 35210 89793034
Sarcoidosis 24.57 9.75 35 800168 10638 89817606
Renal cyst 24.52 9.75 197 800006 12753 89815491
Gangrene 24.45 9.75 196 800007 12680 89815564
Injection site mass 24.41 9.75 106 800097 21984 89806260
Incorrect product administration duration 24.35 9.75 88 800115 19234 89809010
Hypochromic anaemia 24.29 9.75 57 800146 2114 89826130
Deep vein thrombosis postoperative 24.21 9.75 807 799396 70002 89758242
Acute graft versus host disease 24.16 9.75 9 800194 5459 89822785
Lip swelling 24.12 9.75 221 799982 38389 89789855
Injection site discolouration 24.11 9.75 28 800175 9292 89818952
Neuroleptic malignant syndrome 23.84 9.75 62 800141 15034 89813210
Impaired quality of life 23.82 9.75 114 800089 23030 89805214
Respiratory depression 23.81 9.75 65 800138 15510 89812734
Orthostatic hypotension 23.78 9.75 245 799958 41582 89786662
Erysipelas 23.73 9.75 149 800054 8903 89819341
Cardiotoxicity 23.69 9.75 40 800163 11349 89816895
Hyperkalaemia 23.66 9.75 746 799457 64218 89764026
Glomerulonephropathy 23.64 9.75 14 800189 102 89828142
Rectal haemorrhage 23.62 9.75 924 799279 81820 89746424
Amenorrhoea 23.62 9.75 42 800161 11680 89816564
Condition aggravated 23.56 9.75 4770 795433 590775 89237469
Intermenstrual bleeding 23.54 9.75 28 800175 9195 89819049
Asthma-chronic obstructive pulmonary disease overlap syndrome 23.51 9.75 7 800196 4892 89823352
Lethargy 23.40 9.75 404 799799 62735 89765509
Pallor 23.39 9.75 428 799775 33737 89794507
Nephritis allergic 23.39 9.75 21 800182 309 89827935
Poor venous access 23.08 9.75 269 799934 19258 89808986
Chronic gastritis 22.92 9.75 79 800124 3662 89824582
Rhabdomyolysis 22.92 9.75 604 799599 50652 89777592
Eye pruritus 22.85 9.75 156 800047 28871 89799373
Sexual dysfunction 22.81 9.75 7 800196 4797 89823447
Muscle twitching 22.76 9.75 123 800080 24079 89804165
Oedema peripheral 22.73 9.75 2606 797597 255309 89572935
Metastases to bone 22.69 9.75 132 800071 25373 89802871
Demyelination 22.67 9.75 23 800180 8117 89820127
Post procedural hypothyroidism 22.58 9.75 22 800181 361 89827883
Lymphoproliferative disorder 22.54 9.75 5 800198 4257 89823987
Shock 22.49 9.75 155 800048 28623 89799621
Tachyarrhythmia 22.44 9.75 101 800102 5305 89822939
Body mass index abnormal 22.29 9.75 30 800173 709 89827535
Rib deformity 22.22 9.75 19 800184 261 89827983
Neutropenia 22.15 9.75 1697 798506 223207 89605037
Sleep terror 22.12 9.75 6 800197 4458 89823786
Loss of personal independence in daily activities 22.08 9.75 979 799224 135126 89693118
Mood swings 21.88 9.75 101 800102 20601 89807643
Degenerative bone disease 21.76 9.75 19 800184 269 89827975
Joint swelling 21.61 9.75 4888 795315 498412 89329832
Paradoxical drug reaction 21.57 9.75 12 800191 5754 89822490
Discomfort 21.56 9.75 2752 797451 271583 89556661
Sputum discoloured 21.53 9.75 275 799928 20116 89808128
Restlessness 21.24 9.75 438 799765 35282 89792962
Tooth disorder 21.18 9.75 174 800029 30916 89797328
Oestradiol decreased 21.16 9.75 13 800190 102 89828142
Hypergastrinaemia 21.12 9.75 14 800189 127 89828117
Patent ductus arteriosus 21.08 9.75 7 800196 4562 89823682
Hospitalisation 21.07 9.75 920 799283 127180 89701064
Chronic respiratory disease 21.03 9.75 19 800184 282 89827962
Pancreatitis 20.95 9.75 784 799419 69042 89759202
Therapeutic drug monitoring analysis incorrectly performed 20.88 9.75 20 800183 321 89827923
Vomiting 20.82 9.75 7503 792700 780790 89047454
Metastases to lung 20.71 9.75 72 800131 15919 89812325
Cytomegalovirus infection reactivation 20.65 9.75 23 800180 7777 89820467
Fear of injection 20.53 9.75 27 800176 8488 89819756
Synovial fluid analysis 20.41 9.75 63 800140 2755 89825489
Headache 20.36 9.75 7070 793133 855676 88972568
Liver disorder 20.35 9.75 1286 798917 119983 89708261
Cryopyrin associated periodic syndrome 20.18 9.75 25 800178 543 89827701
Haematotoxicity 20.17 9.75 51 800152 12484 89815760
Gastritis erosive 20.15 9.75 115 800088 6640 89821604
Nightmare 20.10 9.75 111 800092 21614 89806630
Adjustment disorder 20.10 9.75 150 800053 9492 89818752
Intestinal villi atrophy 19.97 9.75 20 800183 340 89827904
Paresis 19.96 9.75 61 800142 2653 89825591
Carotid artery thrombosis 19.84 9.75 143 800060 8949 89819295
Injection site induration 19.78 9.75 39 800164 10429 89817815
Retroperitoneal haematoma 19.66 9.75 70 800133 3298 89824946
Basal cell carcinoma 19.63 9.75 194 800009 33195 89795049
Nephrogenic anaemia 19.63 9.75 57 800146 2409 89825835
Therapeutic response unexpected 19.59 9.75 113 800090 21767 89806477
Femoral hernia incarcerated 19.56 9.75 42 800161 1466 89826778
Folate deficiency 19.53 9.75 67 800136 3098 89825146
Thrombosis prophylaxis 19.53 9.75 8 800195 22 89828222
Spinal pain 19.44 9.75 219 799984 15548 89812696
Poisoning 19.38 9.75 69 800134 15148 89813096
Ischaemic stroke 19.36 9.75 289 799914 21877 89806367
Pruritus genital 19.32 9.75 8 800195 4550 89823694
Alanine aminotransferase abnormal 19.30 9.75 12 800191 5414 89822830
Anosmia 19.21 9.75 36 800167 9812 89818432
Haemarthrosis 19.18 9.75 78 800125 3916 89824328
Akathisia 19.06 9.75 44 800159 11115 89817129
Lymphadenopathy 18.92 9.75 287 799916 45488 89782756
White blood cell count abnormal 18.92 9.75 23 800180 7481 89820763
Oesophageal candidiasis 18.91 9.75 114 800089 6715 89821529
Maternal drugs affecting foetus 18.90 9.75 11 800192 5144 89823100
Cholecystitis chronic 18.89 9.75 150 800053 9676 89818568
Salpingo-oophorectomy unilateral 18.79 9.75 32 800171 936 89827308
Complication associated with device 18.76 9.75 98 800105 19351 89808893
Urinary tract infection enterococcal 18.75 9.75 64 800139 2952 89825292
Solar urticaria 18.70 9.75 11 800192 79 89828165
Neuropathy vitamin B12 deficiency 18.69 9.75 5 800198 0 89828244
Confusional arousal 18.69 9.75 18 800185 291 89827953
Therapeutic product effect decreased 18.67 9.75 2759 797444 274812 89553432
Brain contusion 18.56 9.75 26 800177 639 89827605
Sleep disorder 18.55 9.75 2009 798194 196021 89632223
Eye swelling 18.45 9.75 168 800035 29218 89799026
Product administered to patient of inappropriate age 18.42 9.75 9 800194 4644 89823600
Cytomegalovirus viraemia 18.35 9.75 24 800179 7562 89820682
Pharyngeal dystonia 18.33 9.75 6 800197 6 89828238
Therapy cessation 18.28 9.75 219 799984 36142 89792102
Clostridium difficile infection 18.25 9.75 434 799769 35811 89792433
Rash maculo-papular 18.20 9.75 482 799721 40451 89787793
Drug effective for unapproved indication 18.20 9.75 26 800177 7892 89820352
Diastolic dysfunction 18.18 9.75 119 800084 7214 89821030
Abnormal faeces 18.15 9.75 111 800092 6571 89821673
Acute generalised exanthematous pustulosis 18.12 9.75 193 800010 13510 89814734
Disease recurrence 18.10 9.75 229 799974 37424 89790820
Neurologic neglect syndrome 18.08 9.75 137 800066 8710 89819534
Cardiorenal syndrome 18.05 9.75 34 800169 1078 89827166
Osteomyelitis 18.01 9.75 158 800045 27688 89800556
Occupational asthma 17.98 9.75 14 800189 167 89828077
Haemoglobin decreased 17.91 9.75 1662 798541 160294 89667950
Toothache 17.73 9.75 119 800084 22111 89806133
Diverticulitis intestinal perforated 17.65 9.75 20 800183 394 89827850
COVID-19 17.58 9.75 1268 798935 167575 89660669
Fluid intake reduced 17.55 9.75 78 800125 4074 89824170
Jaundice 17.50 9.75 393 799810 32124 89796120
Haematuria 17.49 9.75 418 799785 34519 89793725
Vocal cord dysfunction 17.46 9.75 30 800173 884 89827360
Diarrhoea haemorrhagic 17.44 9.75 157 800046 10506 89817738
Aortic valve stenosis 17.43 9.75 79 800124 4161 89824083
Renal tubular necrosis 17.42 9.75 201 800002 14354 89813890
Productive cough 17.42 9.75 840 799363 76223 89752021
Cardiovascular disorder 17.36 9.75 189 800014 13303 89814941
BK virus infection 17.36 9.75 9 800194 4489 89823755
Breath sounds abnormal 17.32 9.75 210 799993 15176 89813068
Electrocardiogram QT prolonged 17.28 9.75 497 799706 71959 89756285
Palmar-plantar erythrodysaesthesia syndrome 17.25 9.75 161 800042 27862 89800382
Abdominal wall wound 17.23 9.75 11 800192 93 89828151
Deafness 17.23 9.75 122 800081 22392 89805852
Blood iron abnormal 17.13 9.75 7 800196 4013 89824231
Rhinitis allergic 17.09 9.75 83 800120 16702 89811542
Pain in extremity 17.07 9.75 3616 796587 446913 89381331
Product quality issue 16.98 9.75 552 799651 78773 89749471
Sopor 16.97 9.75 309 799894 24335 89803909
Chronic sinusitis 16.94 9.75 300 799903 23502 89804742
Ankylosing spondylitis 16.92 9.75 184 800019 12949 89815295
Gastric haemorrhage 16.84 9.75 114 800089 6989 89821255
Herpes zoster 16.77 9.75 674 799529 93970 89734274
Dysphagia 16.76 9.75 1179 799024 111099 89717145
Injection site irritation 16.75 9.75 17 800186 5998 89822246
Peripheral arterial occlusive disease 16.74 9.75 83 800120 4538 89823706
Disturbance in social behaviour 16.73 9.75 8 800195 4180 89824064
Flatulence 16.67 9.75 481 799722 40886 89787358
Blood pressure diastolic decreased 16.63 9.75 331 799872 26495 89801749
Status epilepticus 16.62 9.75 98 800105 18776 89809468
Hypochloraemia 16.62 9.75 56 800147 2566 89825678
Pneumocystis jirovecii pneumonia 16.61 9.75 117 800086 21499 89806745
Blood glucose increased 16.51 9.75 680 799523 94566 89733678
Swollen joint count increased 16.47 9.75 1167 799036 110039 89718205
Truncus arteriosus persistent 16.46 9.75 19 800184 382 89827862
Hepatitis 16.42 9.75 487 799716 70252 89757992
Tongue oedema 16.37 9.75 93 800110 5361 89822883
Agitation 16.32 9.75 459 799744 66639 89761605
Blood pressure measurement 16.27 9.75 19 800184 387 89827857
Anaemia folate deficiency 16.22 9.75 22 800181 524 89827720
Wrong patient 16.20 9.75 28 800175 829 89827415
Haemorrhagic erosive gastritis 16.20 9.75 21 800182 478 89827766
Biliary dyskinesia 16.02 9.75 55 800148 2544 89825700
TP53 gene mutation 15.97 9.75 9 800194 59 89828185
Reactive gastropathy 15.97 9.75 24 800179 630 89827614
Tuberculosis 15.92 9.75 57 800146 12492 89815752
Maternal exposure during delivery 15.90 9.75 7 800196 3839 89824405
Adverse drug reaction 15.88 9.75 855 799348 115846 89712398
Pericarditis 15.84 9.75 2665 797538 267486 89560758
Adjustment disorder with depressed mood 15.79 9.75 632 799571 56121 89772123
Tenosynovitis stenosans 15.77 9.75 73 800130 3880 89824364
Presyncope 15.76 9.75 380 799823 31425 89796819
Miosis 15.72 9.75 38 800165 9446 89818798
Cytopenia 15.69 9.75 90 800113 17359 89810885
Bursitis 15.62 9.75 1358 798845 130296 89697948
Stillbirth 15.61 9.75 26 800177 7417 89820827
Intraocular pressure increased 15.61 9.75 24 800179 7069 89821175
Pseudarthrosis 15.60 9.75 20 800183 450 89827794
Pleuritic pain 15.59 9.75 151 800052 10310 89817934
Megacolon 15.58 9.75 49 800154 2165 89826079
Transplant rejection 15.49 9.75 59 800144 12699 89815545
Underdose 15.41 9.75 361 799842 53656 89774588
Gestational hypertension 15.39 9.75 4 800199 3058 89825186
Enteritis 15.39 9.75 149 800054 10172 89818072
Withdrawal syndrome 15.37 9.75 126 800077 22398 89805846
Cystostomy 15.26 9.75 9 800194 65 89828179
Diffuse large B-cell lymphoma recurrent 15.25 9.75 6 800197 3520 89824724
Disability assessment scale score increased 15.25 9.75 72 800131 3859 89824385
Osteonecrosis of jaw 15.21 9.75 248 799955 38855 89789389
Ventricular tachycardia 15.19 9.75 142 800061 24566 89803678
Burning sensation 15.19 9.75 435 799768 63017 89765227
Hepatitis acute 15.18 9.75 155 800048 10732 89817512
Sensitisation 15.17 9.75 9 800194 4166 89824078
Lipoedema 15.11 9.75 17 800186 332 89827912
Lung opacity 15.11 9.75 99 800104 6003 89822241
Infusion site pain 15.08 9.75 107 800096 19631 89808613
Hepatic vein dilatation 15.05 9.75 6 800197 15 89828229
Allergy test positive 15.03 9.75 25 800178 717 89827527
Normal newborn 14.91 9.75 133 800070 23229 89805015
Spinal compression fracture 14.91 9.75 76 800127 15102 89813142
Acute megakaryocytic leukaemia 14.90 9.75 8 800195 47 89828197
Lymphatic fistula 14.89 9.75 37 800166 1424 89826820
Internal haemorrhage 14.85 9.75 100 800103 6120 89822124
Sensory level abnormal 14.82 9.75 12 800191 152 89828092
Neoplasm progression 14.81 9.75 290 799913 44196 89784048
Osteonecrosis 14.79 9.75 154 800049 26087 89802157
Neutrophil function disorder 14.78 9.75 6 800197 16 89828228
Troponin abnormal 14.71 9.75 9 800194 70 89828174
Extrapyramidal disorder 14.71 9.75 84 800119 16219 89812025
Gastric perforation 14.60 9.75 45 800158 1966 89826278
Mucous stools 14.60 9.75 88 800115 5183 89823061
Bicytopenia 14.58 9.75 69 800134 3702 89824542
Drug-induced liver injury 14.58 9.75 650 799553 89668 89738576
Inflammation 14.52 9.75 1368 798835 177224 89651020
Lactic acidosis 14.52 9.75 564 799639 49899 89778345
Carcinoid tumour of the stomach 14.45 9.75 12 800191 158 89828086
Mouth breathing 14.45 9.75 12 800191 158 89828086
Graft versus host disease in skin 14.44 9.75 8 800195 3845 89824399
Hyperprolactinaemia 14.40 9.75 16 800187 5417 89822827
Haematocrit decreased 14.36 9.75 477 799726 41355 89786889
Postoperative renal failure 14.35 9.75 11 800192 128 89828116
Myocardial infarction 14.30 9.75 777 799426 105195 89723049
Haemophagocytic lymphohistiocytosis 14.30 9.75 79 800124 15380 89812864
Neurotoxicity 14.24 9.75 121 800082 21346 89806898
Pulmonary tuberculosis 14.23 9.75 13 800190 4821 89823423
Therapeutic reaction time decreased 14.19 9.75 67 800136 3591 89824653
Hepatic steatosis 14.18 9.75 427 799776 36518 89791726
Clostridium colitis 14.15 9.75 45 800158 2000 89826244
Prerenal failure 14.14 9.75 46 800157 2069 89826175
Psoriatic arthropathy 14.12 9.75 2259 797944 226076 89602168
Unresponsive to stimuli 14.10 9.75 244 799959 37877 89790367
Gastrointestinal angiodysplasia 14.08 9.75 22 800181 598 89827646
Musculoskeletal stiffness 14.06 9.75 2352 797851 294180 89534064
Incorrect dose administered by device 14.03 9.75 18 800185 5719 89822525
Injection site scab 14.00 9.75 23 800180 653 89827591
Tongue disorder 13.99 9.75 49 800154 10811 89817433
Dermatitis contact 13.97 9.75 67 800136 13528 89814716
Lymphoma 13.96 9.75 67 800136 13524 89814720
Toxic optic neuropathy 13.88 9.75 14 800189 240 89828004
Anger 13.88 9.75 68 800135 13652 89814592
Wheelchair user 13.87 9.75 30 800173 7755 89820489
Exercise tolerance decreased 13.83 9.75 114 800089 7437 89820807
Eosinophils urine present 13.81 9.75 6 800197 20 89828224
Rabies 13.81 9.75 6 800197 20 89828224
Tricuspid valve incompetence 13.79 9.75 216 799987 16515 89811729
Faeces hard 13.78 9.75 61 800142 3181 89825063
Gastrointestinal procedural complication 13.68 9.75 19 800184 463 89827781
Fluid retention 13.66 9.75 928 799275 87163 89741081
Spontaneous haematoma 13.61 9.75 31 800172 1127 89827117
Pneumonitis chemical 13.59 9.75 16 800187 329 89827915
Haemoptysis 13.58 9.75 388 799815 32932 89795312
Discontinued product administered 13.58 9.75 10 800193 109 89828135
Metabolic surgery 13.57 9.75 38 800165 1573 89826671
Interstitial lung disease 13.56 9.75 544 799659 75861 89752383
Intestinal anastomosis complication 13.55 9.75 16 800187 330 89827914
Creatinine renal clearance increased 13.52 9.75 6 800197 3275 89824969
Arterial haemorrhage 13.52 9.75 51 800152 2472 89825772
Psychological trauma 13.51 9.75 34 800169 1319 89826925
Dermatitis acneiform 13.51 9.75 22 800181 6332 89821912
Device use issue 13.50 9.75 8 800195 3705 89824539
Infective pulmonary exacerbation of cystic fibrosis 13.50 9.75 46 800157 10233 89818011
Dyskinesia 13.46 9.75 234 799969 36300 89791944
Gastrointestinal vascular malformation haemorrhagic 13.41 9.75 13 800190 212 89828032
Photodermatosis 13.35 9.75 21 800182 574 89827670
Shock haemorrhagic 13.30 9.75 166 800037 12079 89816165
Fear 13.25 9.75 89 800114 16533 89811711
Cognitive disorder 13.24 9.75 490 799713 68917 89759327
Ulcer haemorrhage 13.20 9.75 315 799888 26006 89802238
Injury associated with device 13.14 9.75 12 800191 4452 89823792
Suspected suicide 13.13 9.75 42 800161 9526 89818718
Dilatation intrahepatic duct acquired 13.12 9.75 24 800179 744 89827500
Acne 13.10 9.75 175 800028 28332 89799912
Colitis erosive 13.07 9.75 13 800190 219 89828025
Pulmonary embolism 13.07 9.75 1333 798870 129487 89698757
Myalgia 13.04 9.75 1350 798853 173775 89654469
Post procedural pulmonary embolism 13.02 9.75 13 800190 220 89828024
Syncope 13 9.75 1350 798853 131313 89696931
Foetal growth restriction 12.99 9.75 41 800162 9339 89818905
Bacterial test 12.95 9.75 30 800173 1103 89827141
Dysuria 12.95 9.75 447 799756 38954 89789290
Device leakage 12.93 9.75 45 800158 9946 89818298
Potentiating drug interaction 12.91 9.75 90 800113 5572 89822672
Bone disorder 12.91 9.75 136 800067 22984 89805260
Subileus 12.88 9.75 65 800138 3579 89824665
Total lung capacity abnormal 12.86 9.75 9 800194 90 89828154
Personality disorder 12.79 9.75 167 800036 12277 89815967
Macular degeneration 12.79 9.75 432 799771 37538 89790706
Anaesthesia oral 12.74 9.75 4 800199 3 89828241
Cardiac dysfunction 12.73 9.75 8 800195 3589 89824655
Petit mal epilepsy 12.71 9.75 15 800188 4943 89823301
Laryngeal stenosis 12.70 9.75 33 800170 1306 89826938
Hyperammonaemic encephalopathy 12.69 9.75 4 800199 2695 89825549
Blood parathyroid hormone decreased 12.67 9.75 60 800143 12156 89816088
Dry eye 12.67 9.75 402 799801 57529 89770715
Disease risk factor 12.66 9.75 13 800190 228 89828016
Wound infection pseudomonas 12.64 9.75 43 800160 1980 89826264
Oligohydramnios 12.62 9.75 28 800175 7173 89821071
Loss of consciousness 12.59 9.75 1066 799137 139172 89689072
Hepatocellular injury 12.59 9.75 340 799863 28618 89799626
Tachypnoea 12.58 9.75 261 799942 21048 89807196
Glycosylated haemoglobin increased 12.57 9.75 83 800120 15479 89812765
Rash papular 12.50 9.75 117 800086 20238 89808006
Polymyalgia rheumatica 12.48 9.75 81 800122 4896 89823348
Intentional product misuse 12.47 9.75 655 799548 88949 89739295
Aortic occlusion 12.46 9.75 10 800193 125 89828119
Arterial stenosis 12.46 9.75 23 800180 718 89827526
Glucose tolerance impaired 12.45 9.75 33 800170 7952 89820292
Limb deformity 12.42 9.75 11 800192 4141 89824103
Application site pain 12.40 9.75 14 800189 4706 89823538
Lower limb fracture 12.39 9.75 891 799312 84122 89744122
Subcutaneous drug absorption impaired 12.38 9.75 178 800025 13367 89814877
Carcinoid tumour 12.37 9.75 17 800186 410 89827834
Eosinophilic oesophagitis 12.36 9.75 25 800178 836 89827408
Skin burning sensation 12.36 9.75 112 800091 19499 89808745
Craniofacial fracture 12.36 9.75 18 800185 459 89827785
Intentional dose omission 12.36 9.75 99 800104 17684 89810560
Bone density abnormal 12.35 9.75 11 800192 4129 89824115
Metabolic disorder 12.32 9.75 30 800173 7440 89820804
Delirium 12.31 9.75 1076 799127 103283 89724961
Ocular hyperaemia 12.29 9.75 217 799986 33581 89794663
Lung neoplasm malignant 12.28 9.75 146 800057 24127 89804117
Cardiovascular insufficiency 12.26 9.75 37 800166 1598 89826646
Porphyria acute 12.24 9.75 225 799978 17750 89810494
Lipase increased 12.23 9.75 151 800052 10960 89817284
Gastrointestinal inflammation 12.21 9.75 101 800102 6595 89821649
Alveolitis 12.21 9.75 56 800147 2965 89825279
Renal atrophy 12.18 9.75 40 800163 1808 89826436
Blood pressure increased 12.17 9.75 1951 798252 195266 89632978
Disseminated tuberculosis 12.15 9.75 7 800196 3292 89824952
Peripheral venous disease 12.14 9.75 879 799324 83042 89745202
Feeling jittery 12.13 9.75 197 800006 15174 89813070
Mental impairment 12.12 9.75 92 800111 16628 89811616
Atrial septal defect 12.12 9.75 35 800168 8199 89820045
Spigelian hernia 12.11 9.75 6 800197 29 89828215
Administration site discomfort 12.08 9.75 10 800193 131 89828113
Carpal tunnel syndrome 12.08 9.75 144 800059 23784 89804460
Hallucination 12.06 9.75 468 799735 65491 89762753
Colorectal cancer 12.03 9.75 10 800193 3883 89824361
Hypoparathyroidism 11.99 9.75 27 800176 974 89827270
Vaccination site reaction 11.96 9.75 13 800190 244 89828000
Hyperchlorhydria 11.90 9.75 41 800162 1900 89826344
Maternal exposure during breast feeding 11.90 9.75 23 800180 6197 89822047
Diabetic ketoacidosis 11.89 9.75 148 800055 24259 89803985
Acquired haemophilia 11.89 9.75 28 800175 1041 89827203
Embedded device 11.83 9.75 12 800191 4236 89824008
Enterochromaffin cell hyperplasia 11.82 9.75 7 800196 51 89828193
Dislocation of vertebra 11.80 9.75 606 799597 55362 89772882
Hypopnoea 11.80 9.75 13 800190 4418 89823826
Congenital cardiovascular anomaly 11.77 9.75 18 800185 480 89827764
Tardive dyskinesia 11.74 9.75 53 800150 10877 89817367
Panniculitis 11.73 9.75 77 800126 14381 89813863
Drug withdrawal syndrome neonatal 11.71 9.75 3 800200 2316 89825928
Lung disorder 11.69 9.75 1503 798700 148380 89679864
Pneumatosis intestinalis 11.68 9.75 8 800195 3429 89824815
Pancytopenia 11.67 9.75 1223 798980 119040 89709204
Bacterial colitis 11.66 9.75 11 800192 173 89828071
Intestinal intraepithelial lymphocytes increased 11.66 9.75 5 800198 16 89828228
Ejection fraction 11.65 9.75 6 800197 3005 89825239
Humerus fracture 11.65 9.75 135 800068 9650 89818594
Glomerulonephritis chronic 11.60 9.75 10 800193 139 89828105
Atrial tachycardia 11.59 9.75 22 800181 5968 89822276
Mucormycosis 11.58 9.75 10 800193 3811 89824433
Cross sensitivity reaction 11.58 9.75 53 800150 2804 89825440
Hyperreflexia 11.57 9.75 26 800177 6631 89821613
Acute graft versus host disease in skin 11.55 9.75 15 800188 4741 89823503
Flank pain 11.53 9.75 236 799967 18986 89809258
Hyperammonaemia 11.49 9.75 25 800178 6450 89821794
Neurosensory hypoacusis 11.48 9.75 12 800191 215 89828029
Occupational exposure to product 11.47 9.75 4 800199 2527 89825717
Pelvic haematoma 11.41 9.75 22 800181 710 89827534
Granuloma skin 11.35 9.75 52 800151 10628 89817616
Asphyxia 11.35 9.75 29 800174 7074 89821170
Renal haemangioma 11.35 9.75 6 800197 34 89828210
Non-economic loss 11.22 9.75 5 800198 18 89828226
Tinnitus 11.22 9.75 292 799911 42810 89785434
Speech rehabilitation 11.22 9.75 3 800200 0 89828244
Stiff leg syndrome 11.22 9.75 3 800200 0 89828244
Abdominal wall cyst 11.21 9.75 6 800197 35 89828209
Toxic anterior segment syndrome 11.20 9.75 3 800200 2247 89825997
Drug tolerance decreased 11.19 9.75 367 799836 31763 89796481
Polyomavirus-associated nephropathy 11.17 9.75 4 800199 2486 89825758
Pharyngitis 11.11 9.75 132 800071 21815 89806429
Gastric polyps 11.09 9.75 75 800128 4597 89823647
Bone marrow failure 11.05 9.75 209 799994 32012 89796232
Congenital coronary artery malformation 11.04 9.75 10 800193 149 89828095
Rash erythematous 11.03 9.75 691 799512 64413 89763831
Serositis 11.03 9.75 31 800172 1286 89826958
Vascular access site complication 11.02 9.75 5 800198 19 89828225
Pseudomembranous colitis 10.98 9.75 65 800138 3803 89824441
Premature labour 10.97 9.75 71 800132 13305 89814939
Rectal prolapse repair 10.97 9.75 4 800199 7 89828237
Faeces discoloured 10.95 9.75 256 799947 21064 89807180
Ileocolostomy 10.94 9.75 6 800197 37 89828207
Inflammatory marker increased 10.92 9.75 127 800076 9087 89819157
Gastrointestinal ulcer haemorrhage 10.90 9.75 25 800178 913 89827331
Eye disorder 10.89 9.75 173 800030 27217 89801027
Blood pressure inadequately controlled 10.88 9.75 93 800110 6131 89822113
Product preparation error 10.88 9.75 50 800153 10211 89818033
B-lymphocyte count increased 10.87 9.75 9 800194 118 89828126
Glomerular filtration rate decreased 10.86 9.75 210 799993 16722 89811522
Faeces pale 10.79 9.75 40 800163 1923 89826321
Chest pain 10.77 9.75 3072 797131 316573 89511671
Hyperplastic cholecystopathy 10.77 9.75 10 800193 154 89828090
Product adhesion issue 10.75 9.75 18 800185 5124 89823120
Low birth weight baby 10.72 9.75 45 800158 9422 89818822
Hemiparesis 10.71 9.75 362 799841 31457 89796787
Gait deviation 10.70 9.75 7 800196 62 89828182
Organising pneumonia 10.67 9.75 33 800170 7564 89820680
Rapid eye movement sleep behaviour disorder 10.67 9.75 15 800188 370 89827874
Duodenal polyp 10.64 9.75 12 800191 235 89828009
Lactescent serum 10.63 9.75 4 800199 8 89828236
Frustration tolerance decreased 10.60 9.75 35 800168 7861 89820383
N-terminal prohormone brain natriuretic peptide increased 10.59 9.75 53 800150 2909 89825335
Transplant dysfunction 10.58 9.75 19 800184 5263 89822981
HIV infection 10.57 9.75 17 800186 474 89827770
Diplopia 10.55 9.75 184 800019 28530 89799714
Postpartum haemorrhage 10.53 9.75 4 800199 2397 89825847
Faeces soft 10.50 9.75 107 800096 7404 89820840
Osteochondrosis 10.50 9.75 38 800165 1805 89826439
Acute respiratory distress syndrome 10.49 9.75 184 800019 28502 89799742
Crepitations 10.48 9.75 122 800081 8730 89819514
Cholecystitis 10.48 9.75 210 799993 16830 89811414
Sebaceous gland infection 10.47 9.75 10 800193 160 89828084
Myeloblast percentage decreased 10.44 9.75 6 800197 41 89828203
Implant site pain 10.42 9.75 5 800198 2607 89825637
Nephrolithiasis 10.40 9.75 342 799861 48743 89779501
Parkinsonism 10.38 9.75 77 800126 13988 89814256
Staphylococcal infection 10.38 9.75 337 799866 48102 89780142
Wound infection fungal 10.37 9.75 10 800193 162 89828082
Nasal mucosal disorder 10.34 9.75 38 800165 1819 89826425
Urine viscosity increased 10.33 9.75 6 800197 42 89828202
Product prescribing issue 10.28 9.75 36 800167 7943 89820301
Gastroenteritis salmonella 10.26 9.75 23 800180 827 89827417
Upper respiratory tract irritation 10.22 9.75 11 800192 204 89828040
Hemiplegia 10.22 9.75 200 800003 15960 89812284
Epigastric discomfort 10.20 9.75 107 800096 7461 89820783
Atelectasis 10.16 9.75 285 799918 24124 89804120
Abnormal dreams 10.15 9.75 58 800145 11199 89817045
Eye discharge 10.15 9.75 38 800165 8220 89820024
Cardiac failure congestive 10.14 9.75 742 799461 97952 89730292
Bone lesion 10.13 9.75 94 800109 6343 89821901
Dental caries 10.13 9.75 59 800144 11338 89816906
Renal pain 10.13 9.75 109 800094 7650 89820594
Cerebellar ataxia 10.09 9.75 24 800179 898 89827346
Carotid artery occlusion 10.05 9.75 26 800177 6316 89821928
Emphysema 10.05 9.75 157 800046 11998 89816246
Respiratory tract congestion 10.04 9.75 315 799888 27095 89801149
Gastrointestinal complication associated with device 10.03 9.75 4 800199 10 89828234
Cutaneous lymphoma 10.03 9.75 10 800193 169 89828075
Hepatic enzyme 10.02 9.75 20 800183 5324 89822920
Blood glucose decreased 9.99 9.75 146 800057 23283 89804961
Appetite disorder 9.99 9.75 44 800159 9089 89819155
Wrong technique in device usage process 9.97 9.75 23 800180 5812 89822432
Alanine aminotransferase increased 9.97 9.75 904 799299 117434 89710810
Menstruation irregular 9.97 9.75 37 800166 8023 89820221
Anaphylactic shock 9.96 9.75 208 799995 31409 89796835
Infusion site reaction 9.90 9.75 229 799974 18810 89809434
Paralysis 9.90 9.75 60 800143 11418 89816826
Electroencephalogram abnormal 9.87 9.75 13 800190 4083 89824161
Endotracheal intubation 9.86 9.75 57 800146 3307 89824937
Anti-cyclic citrullinated peptide antibody positive 9.82 9.75 2293 797910 234140 89594104
Haemodynamic instability 9.79 9.75 62 800141 11677 89816567
Prothrombin time shortened 9.79 9.75 43 800160 2235 89826009
Tetany 9.78 9.75 47 800156 2537 89825707
Maternal exposure timing unspecified 9.78 9.75 264 799939 22219 89806025
Blood lactic acid increased 9.77 9.75 42 800161 8736 89819508
Femoral pulse decreased 9.76 9.75 4 800199 11 89828233
Benign gastric neoplasm 9.76 9.75 4 800199 11 89828233
Fracture blisters 9.76 9.75 7 800196 73 89828171
Dermatitis atopic 9.76 9.75 147 800056 23325 89804919

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1025.60 11.02 3253 365022 147993 42105067
Drug ineffective 848.20 11.02 2719 365556 627478 41625582
Toxicity to various agents 515.69 11.02 738 367537 228398 42024662
Hypomagnesaemia 446.32 11.02 847 367428 27641 42225419
Completed suicide 401.87 11.02 165 368110 96300 42156760
Systemic infection 321.99 11.02 304 367971 4901 42248159
Drug abuse 307.97 11.02 271 368004 104500 42148560
Chronic kidney disease 278.21 11.02 970 367305 46271 42206789
Hypocalcaemia 271.38 11.02 719 367556 29454 42223606
Product prescribing error 261.52 11.02 648 367627 25464 42227596
Anaemia 246.85 11.02 3590 364685 276688 41976372
Off label use 213.31 11.02 4064 364211 634271 41618789
Acute kidney injury 168.93 11.02 4259 364016 363078 41889982
Haematochezia 165.91 11.02 966 367309 57470 42195590
Product use in unapproved indication 151.79 11.02 952 367323 183504 42069556
Death 150.13 11.02 3022 365253 468163 41784897
Dyspnoea 145.40 11.02 4920 363355 437701 41815359
Electrolyte imbalance 139.28 11.02 393 367882 16708 42236352
Intentional product misuse 139.26 11.02 199 368076 61701 42191359
Treatment failure 131.55 11.02 211 368064 62413 42190647
Drug ineffective for unapproved indication 128.94 11.02 125 368150 46038 42207022
Product monitoring error 127.99 11.02 174 368101 4249 42248811
Hepatic function abnormal 119.78 11.02 162 368113 51405 42201655
Drug resistance 119.42 11.02 74 368201 34174 42218886
Syncope 117.43 11.02 1345 366930 98061 42154999
Cholestasis 116.75 11.02 578 367697 32301 42220759
Melaena 107.68 11.02 637 367638 38109 42214951
Intentional overdose 106.54 11.02 175 368100 51281 42201779
Product dose omission issue 104.81 11.02 842 367433 153523 42099537
Hypokalaemia 104.73 11.02 1013 367262 70708 42182352
Agranulocytosis 102.96 11.02 530 367745 30082 42222978
Foetal exposure during pregnancy 101.64 11.02 157 368118 47154 42205906
Disease progression 101.52 11.02 775 367500 142881 42110179
Atrial fibrillation 100.51 11.02 1730 366545 137863 42115197
Overdose 94.59 11.02 528 367747 104736 42148324
Myelosuppression 91.07 11.02 130 368145 40331 42212729
Abdominal pain lower 86.16 11.02 265 368010 11827 42241233
Renal injury 85.53 11.02 267 368008 12013 42241047
Haematemesis 84.23 11.02 497 367778 29702 42223358
Neuropathy peripheral 84.03 11.02 525 367750 101328 42151732
Erysipelas 80.41 11.02 172 368103 6124 42246936
Abdominal pain upper 78.35 11.02 1073 367202 81536 42171524
Full blood count abnormal 76.56 11.02 481 367794 29395 42223665
Dyspnoea exertional 76.01 11.02 714 367561 49434 42203626
Sedation 75.67 11.02 91 368184 30384 42222676
Oedema peripheral 74.93 11.02 1619 366656 134457 42118603
Dyspnoea at rest 74.92 11.02 133 368142 4116 42248944
Abdominal pain 72.34 11.02 2156 366119 188315 42064745
Rash 72.04 11.02 1832 366443 275122 41977938
Rash maculo-papular 71.57 11.02 562 367713 36941 42216119
Irritability 68.78 11.02 85 368190 28043 42225017
Cytomegalovirus infection 68.63 11.02 108 368167 32198 42220862
Therapy partial responder 67.42 11.02 45 368230 19976 42233084
Premature baby 66.63 11.02 61 368214 23092 42229968
Blood loss anaemia 66.26 11.02 210 368065 9526 42243534
Tricuspid valve incompetence 64.35 11.02 227 368048 10886 42242174
Labelled drug-drug interaction medication error 63.39 11.02 285 367990 15297 42237763
Hepatitis cholestatic 63.32 11.02 208 368067 9616 42243444
Gastrooesophageal reflux disease 63.29 11.02 631 367644 44392 42208668
Therapy non-responder 63.13 11.02 242 368033 53117 42199943
Benign prostatic hyperplasia 62.98 11.02 353 367922 20699 42232361
Nightmare 62.84 11.02 74 368201 24938 42228122
Drug use disorder 61.99 11.02 8 368267 10325 42242735
Diastolic dysfunction 59.34 11.02 163 368112 6820 42246240
Cardiac failure 58.68 11.02 1271 367004 105585 42147475
Gastritis 57.94 11.02 380 367895 23567 42229493
Febrile infection 57.14 11.02 93 368182 2678 42250382
Normocytic anaemia 56.79 11.02 107 368168 3470 42249590
Blood phosphorus increased 56.18 11.02 19 368256 12506 42240554
Respiratory arrest 55.78 11.02 100 368175 28324 42224736
Acute abdomen 55.73 11.02 78 368197 1959 42251101
Asthenia 55.62 11.02 2962 365313 277831 41975229
Gastrointestinal haemorrhage 55.14 11.02 1167 367108 96559 42156501
Leukopenia 54.69 11.02 929 367346 73817 42179243
Pathogen resistance 53.79 11.02 16 368259 11434 42241626
Asthma 52.54 11.02 793 367482 61521 42191539
Pneumonia salmonella 51.90 11.02 21 368254 57 42253003
Cardiac arrest 51.38 11.02 651 367624 108669 42144391
Right atrial hypertrophy 51.33 11.02 46 368229 691 42252369
Musculoskeletal pain 51.17 11.02 476 367799 32864 42220196
Eosinophilia 51.14 11.02 471 367804 32428 42220632
Abnormal behaviour 51.06 11.02 94 368181 26357 42226703
Occult blood 50.58 11.02 52 368223 934 42252126
Hypoparathyroidism 50.00 11.02 45 368230 680 42252380
Mitral valve incompetence 49.66 11.02 277 367998 16212 42236848
Lower respiratory tract infection 49.31 11.02 186 368089 41020 42212040
End stage renal disease 48.44 11.02 276 367999 16282 42236778
Post transplant lymphoproliferative disorder 48.17 11.02 10 368265 9110 42243950
Suicide attempt 47.77 11.02 220 368055 45880 42207180
Appendicitis 47.61 11.02 65 368210 20548 42232512
Urogenital haemorrhage 47.57 11.02 44 368231 690 42252370
Platelet count decreased 47.45 11.02 877 367398 137704 42115356
Carotid arteriosclerosis 46.38 11.02 77 368198 2255 42250805
Therapeutic response decreased 46.31 11.02 164 368111 36848 42216212
Neutrophil count decreased 46.23 11.02 339 367936 63076 42189984
Somnolence 46.15 11.02 900 367375 140205 42112855
Therapeutic drug monitoring analysis not performed 45.92 11.02 39 368236 543 42252517
Multiple-drug resistance 45.58 11.02 5 368270 7317 42245743
Incorrect route of product administration 45.49 11.02 88 368187 24217 42228843
Bronchial secretion retention 44.66 11.02 62 368213 1545 42251515
Stress 44.63 11.02 213 368062 43999 42209061
Injection site pain 44.56 11.02 304 367971 57494 42195566
Immune reconstitution inflammatory syndrome 44.44 11.02 16 368259 10127 42242933
Accidental overdose 43.69 11.02 114 368161 28216 42224844
Drug reaction with eosinophilia and systemic symptoms 42.97 11.02 554 367721 41521 42211539
Hypercholesterolaemia 42.87 11.02 222 368053 12627 42240433
Feeling abnormal 42.24 11.02 392 367883 69394 42183666
Pallor 41.64 11.02 407 367868 28479 42224581
Bronchial wall thickening 41.64 11.02 55 368220 1305 42251755
Acute graft versus host disease 41.39 11.02 10 368265 8205 42244855
Suicidal ideation 41.39 11.02 245 368030 47916 42205144
Synovitis 41.35 11.02 44 368231 15523 42237537
Aortic valve stenosis 41.24 11.02 85 368190 2947 42250113
Psychotic disorder 40.99 11.02 123 368152 29085 42223975
Impaired work ability 40.95 11.02 27 368248 12064 42240996
Malaise 40.82 11.02 1461 366814 210695 42042365
Drug hypersensitivity 40.56 11.02 609 367666 98780 42154280
Chronic graft versus host disease 40.50 11.02 3 368272 6022 42247038
Colitis microscopic 40.48 11.02 86 368189 3047 42250013
C-reactive protein increased 40.15 11.02 772 367503 62788 42190272
No adverse event 39.97 11.02 187 368088 38834 42214226
Dizziness 39.90 11.02 2580 365695 246674 42006386
Upper gastrointestinal haemorrhage 39.88 11.02 419 367856 29880 42223180
Extrapyramidal disorder 39.70 11.02 50 368225 16362 42236698
Malignant melanoma in situ 39.33 11.02 79 368196 2688 42250372
Presyncope 39.20 11.02 329 367946 22058 42231002
Drug intolerance 38.50 11.02 477 367798 79947 42173113
Prostate cancer 38.42 11.02 227 368048 44416 42208644
Angina pectoris 38.30 11.02 444 367831 32452 42220608
Adjustment disorder 37.63 11.02 52 368223 1290 42251770
Device leakage 37.58 11.02 21 368254 10264 42242796
Insomnia 37.52 11.02 758 367517 117495 42135565
Tinnitus 37.03 11.02 127 368148 28811 42224249
Interstitial lung disease 36.94 11.02 467 367808 77995 42175065
Glomerular filtration rate decreased 36.88 11.02 255 368020 16096 42236964
Reversible airways obstruction 36.88 11.02 35 368240 568 42252492
Shock haemorrhagic 36.46 11.02 253 368022 15989 42237071
Infective exacerbation of chronic obstructive airways disease 36.32 11.02 64 368211 1969 42251091
Obstructive airways disorder 36.25 11.02 350 367925 24409 42228651
Hiatus hernia 35.90 11.02 158 368117 8402 42244658
Cerebral infarction 35.82 11.02 143 368132 31026 42222034
Migraine 35.68 11.02 107 368168 25307 42227753
Congenital hiatus hernia 35.65 11.02 126 368149 6048 42247012
Peripheral arterial occlusive disease 35.64 11.02 135 368140 6703 42246357
Acute graft versus host disease in skin 35.57 11.02 10 368265 7414 42245646
Diverticulum intestinal 35.45 11.02 111 368164 5002 42248058
Haematoma 35.24 11.02 384 367891 27639 42225421
Substance use disorder 34.99 11.02 3 368272 5342 42247718
Exposure during pregnancy 34.95 11.02 15 368260 8533 42244527
Gastrointestinal bacterial overgrowth 34.92 11.02 19 368256 118 42252942
Joint swelling 34.64 11.02 398 367877 67624 42185436
Seizure 34.13 11.02 787 367488 119774 42133286
Serum ferritin decreased 34.11 11.02 42 368233 927 42252133
Agitation 34.05 11.02 373 367902 63941 42189119
Hydrocholecystis 33.94 11.02 31 368244 478 42252582
Blood pressure systolic increased 33.69 11.02 380 367895 27588 42225472
Syringe issue 33.45 11.02 16 368259 8540 42244520
Hyperlipasaemia 33.40 11.02 33 368242 564 42252496
Body temperature decreased 33.23 11.02 226 368049 14187 42238873
Mucosal haemorrhage 32.82 11.02 57 368218 1733 42251327
Hypoparathyroidism secondary 32.80 11.02 21 368254 183 42252877
Gastritis erosive 32.76 11.02 127 368148 6376 42246684
Thrombotic microangiopathy 32.76 11.02 48 368227 14734 42238326
Vitamin B12 deficiency 32.43 11.02 105 368170 4817 42248243
Systolic dysfunction 32.28 11.02 77 368198 2951 42250109
Aortic valve incompetence 32.27 11.02 127 368148 6421 42246639
Blood pressure increased 32.19 11.02 1129 367146 100799 42152261
Urinary hesitation 32.17 11.02 77 368198 2958 42250102
Intentional self-injury 32.11 11.02 51 368224 15151 42237909
Serotonin syndrome 32.01 11.02 115 368160 25730 42227330
Aggression 31.74 11.02 237 368038 43926 42209134
Blood pressure fluctuation 31.69 11.02 364 367911 26544 42226516
Cytomegalovirus infection reactivation 31.51 11.02 30 368245 11148 42241912
Drug withdrawal syndrome 31.51 11.02 89 368186 21460 42231600
Ventricular enlargement 31.44 11.02 34 368241 649 42252411
Product use issue 31.40 11.02 470 367805 76281 42176779
Injection site haemorrhage 31.37 11.02 33 368242 11703 42241357
Dermatitis exfoliative generalised 31.20 11.02 116 368159 5708 42247352
Microcytic anaemia 31.10 11.02 76 368199 2959 42250101
Thrombocytopenia 30.86 11.02 1972 366303 188307 42064753
Adverse drug reaction 30.82 11.02 193 368082 37241 42215819
Electrocardiogram Q wave abnormal 30.78 11.02 30 368245 504 42252556
Dehydration 30.76 11.02 1509 366766 140258 42112802
Visual acuity reduced 30.75 11.02 66 368209 17484 42235576
Tachyarrhythmia 30.69 11.02 89 368186 3843 42249217
Pancreatitis acute 30.59 11.02 433 367842 33131 42219929
Wrong technique in product usage process 30.55 11.02 229 368046 42406 42210654
Right ventricular hypertrophy 30.54 11.02 51 368224 1501 42251559
Lichenoid keratosis 30.44 11.02 89 368186 3861 42249199
Cardio-respiratory arrest 30.28 11.02 342 367933 58294 42194766
Cytomegalovirus viraemia 30.26 11.02 27 368248 10350 42242710
Bronchopulmonary aspergillosis 30.10 11.02 78 368197 19351 42233709
Accidental exposure to product 29.99 11.02 84 368191 20309 42232751
Solar lentigo 29.96 11.02 32 368243 602 42252458
Withdrawal syndrome 29.88 11.02 51 368224 14724 42238336
Leriche syndrome 29.72 11.02 16 368259 97 42252963
Electrocardiogram abnormal 29.61 11.02 169 368106 9976 42243084
Blindness 29.55 11.02 70 368205 17908 42235152
Productive cough 29.45 11.02 617 367658 50950 42202110
Arrhythmia 29.44 11.02 501 367774 39816 42213244
Fluid intake reduced 29.32 11.02 89 368186 3943 42249117
Pulmonary function test abnormal 29.26 11.02 69 368206 2625 42250435
Cholestatic liver injury 28.99 11.02 84 368191 3625 42249435
Low birth weight baby 28.92 11.02 26 368249 9929 42243131
Steroid dependence 28.78 11.02 11 368264 6711 42246349
Fracture 28.43 11.02 142 368133 7961 42245099
Bladder cancer 28.32 11.02 66 368209 16981 42236079
Haematotoxicity 28.13 11.02 32 368243 10953 42242107
Gamma-glutamyltransferase increased 27.94 11.02 415 367860 32082 42220978
Dysuria 27.88 11.02 400 367875 30696 42222364
Renal cyst 27.85 11.02 165 368110 9874 42243186
Haematoma muscle 27.76 11.02 59 368216 2091 42250969
Hyponatraemia 27.51 11.02 1105 367170 100357 42152703
Arthritis 27.33 11.02 232 368043 41833 42211227
Altered state of consciousness 27.22 11.02 145 368130 29114 42223946
Lower gastrointestinal haemorrhage 27.06 11.02 173 368102 10635 42242425
Breath sounds abnormal 26.92 11.02 188 368087 11905 42241155
Chest X-ray abnormal 26.89 11.02 93 368182 4415 42248645
Photodermatosis 26.85 11.02 33 368242 727 42252333
Lactic acidosis 26.65 11.02 544 367731 44717 42208343
Hepatojugular reflux 26.47 11.02 31 368244 648 42252412
Hypersensitivity 26.33 11.02 453 367822 71917 42181143
White blood cell count decreased 26.32 11.02 739 367536 109657 42143403
Epidural lipomatosis 26.32 11.02 52 368223 1748 42251312
Drug dose omission by device 26.28 11.02 9 368266 5877 42247183
Fall 26.22 11.02 2360 365915 232160 42020900
Akathisia 26.16 11.02 31 368244 10420 42242640
Dysplastic naevus 26.14 11.02 31 368244 657 42252403
Coronary artery disease 26.04 11.02 628 367647 53092 42199968
Ventricular fibrillation 26.00 11.02 153 368122 29970 42223090
Degenerative mitral valve disease 25.96 11.02 21 368254 272 42252788
Chest injury 25.88 11.02 52 368223 1770 42251290
Therapeutic product effect decreased 25.86 11.02 215 368060 38935 42214125
Graft versus host disease 25.78 11.02 45 368230 12880 42240180
Underdose 25.75 11.02 67 368208 16599 42236461
Blood cholesterol increased 25.73 11.02 131 368144 26610 42226450
Ventricular arrhythmia 25.65 11.02 115 368160 6164 42246896
Rectal haemorrhage 25.61 11.02 585 367690 49021 42204039
Forced expiratory volume decreased 25.57 11.02 132 368143 7498 42245562
Wheezing 25.54 11.02 637 367638 54144 42198916
Exposure to toxic agent 25.39 11.02 6 368269 4998 42248062
Disseminated intravascular coagulation 25.28 11.02 119 368156 24675 42228385
Cold sweat 25.14 11.02 176 368099 11154 42241906
Pulmonary vasculitis 25.03 11.02 114 368161 6152 42246908
Hypertensive nephropathy 25.03 11.02 26 368249 473 42252587
Tetanus 24.96 11.02 12 368263 55 42253005
Clostridium test positive 24.93 11.02 104 368171 5401 42247659
Injection site swelling 24.89 11.02 70 368205 16903 42236157
Gingival pain 24.89 11.02 22 368253 8472 42244588
Symmetrical drug-related intertriginous and flexural exanthema 24.89 11.02 34 368241 834 42252226
Respiratory tract haemorrhage 24.71 11.02 44 368231 1365 42251695
Multiple organ dysfunction syndrome 24.58 11.02 644 367631 96391 42156669
Bacterial infection 24.39 11.02 141 368134 27738 42225322
Treatment noncompliance 24.38 11.02 208 368067 37464 42215596
Urosepsis 24.34 11.02 217 368058 14803 42238257
Stomatitis 24.27 11.02 298 367977 50031 42203029
Parkinsonism hyperpyrexia syndrome 24.20 11.02 22 368253 337 42252723
Foetal malformation 24.14 11.02 17 368258 176 42252884
Iron deficiency anaemia 24.10 11.02 194 368081 12845 42240215
Pericardial disease 24.06 11.02 26 368249 496 42252564
Obstruction 23.99 11.02 70 368205 3033 42250027
Hallucination 23.92 11.02 351 367924 57156 42195904
Flushing 23.71 11.02 205 368070 36823 42216237
Gastric xanthoma 23.68 11.02 8 368267 10 42253050
Injection site erythema 23.62 11.02 92 368183 20103 42232957
Drug effective for unapproved indication 23.58 11.02 14 368261 6619 42246441
Aspergillus infection 23.46 11.02 65 368210 15772 42237288
Haematuria 23.46 11.02 660 367615 57139 42195921
Disinhibition 23.40 11.02 3 368272 3892 42249168
Mood swings 23.38 11.02 25 368250 8801 42244259
Anaphylactic shock 23.32 11.02 114 368161 23403 42229657
Myelocyte count increased 23.15 11.02 23 368252 396 42252664
Subileus 23.10 11.02 75 368200 3446 42249614
Epstein-Barr virus infection 23.10 11.02 30 368245 9688 42243372
Alanine aminotransferase abnormal 23.06 11.02 7 368268 4937 42248123
Hypotension 23.05 11.02 2553 365722 255078 41997982
Pulmonary valve disease 23.05 11.02 23 368252 398 42252662
Poisoning 22.78 11.02 59 368216 14640 42238420
Sickle cell anaemia with crisis 22.67 11.02 7 368268 4883 42248177
Dissociation 22.64 11.02 3 368272 3795 42249265
Nephrogenic anaemia 22.61 11.02 61 368214 2525 42250535
Haemoglobin decreased 22.58 11.02 1379 366896 131092 42121968
Neuritis 22.54 11.02 110 368165 6110 42246950
Eye pruritus 22.52 11.02 40 368235 11372 42241688
Memory impairment 22.50 11.02 302 367973 49920 42203140
Occupational dermatitis 22.40 11.02 13 368262 93 42252967
Enthesopathy 22.22 11.02 7 368268 4821 42248239
Injection site bruising 22.20 11.02 41 368234 11484 42241576
Victim of child abuse 21.98 11.02 38 368237 1151 42251909
Type I hypersensitivity 21.94 11.02 54 368221 2112 42250948
Blood pressure diastolic abnormal 21.94 11.02 108 368167 6020 42247040
Electrocardiogram T wave alternans 21.85 11.02 13 368262 98 42252962
Rebound acid hypersecretion 21.85 11.02 13 368262 98 42252962
Gastrointestinal angiodysplasia 21.66 11.02 28 368247 650 42252410
Vascular purpura 21.61 11.02 54 368221 2132 42250928
Graft versus host disease in skin 21.55 11.02 9 368266 5203 42247857
Mucormycosis 21.54 11.02 18 368257 7125 42245935
Neuroleptic malignant syndrome 21.34 11.02 104 368171 21368 42231692
Myasthenia gravis 21.20 11.02 70 368205 16067 42236993
Oesophageal ulcer haemorrhage 21.11 11.02 21 368254 362 42252698
Bicytopenia 21.05 11.02 68 368207 3116 42249944
BK virus infection 21.00 11.02 27 368248 8757 42244303
Oesophageal carcinoma 20.99 11.02 32 368243 9664 42243396
Antineutrophil cytoplasmic antibody positive 20.98 11.02 84 368191 4281 42248779
Cardiotoxicity 20.97 11.02 20 368255 7425 42245635
Status epilepticus 20.87 11.02 67 368208 15511 42237549
Chronic obstructive pulmonary disease 20.64 11.02 702 367573 62412 42190648
Substance abuse 20.64 11.02 28 368247 8877 42244183
Lethargy 20.63 11.02 283 367992 46607 42206453
Alcohol poisoning 20.58 11.02 21 368254 7553 42245507
Autoimmune colitis 20.49 11.02 36 368239 1105 42251955
Mean cell haemoglobin decreased 20.33 11.02 51 368224 2019 42251041
Fear of disease 20.32 11.02 18 368257 266 42252794
Product storage error 20.27 11.02 41 368234 11099 42241961
Granulocytes maturation arrest 20.23 11.02 8 368267 20 42253040
Heart rate decreased 20.18 11.02 435 367840 36097 42216963
Cardiac aneurysm 20.06 11.02 35 368240 1068 42251992
Transplant rejection 19.96 11.02 56 368219 13532 42239528
Acetabulum fracture 19.94 11.02 22 368253 430 42252630
Sinusitis 19.89 11.02 288 367987 47004 42206056
Anaphylactic reaction 19.89 11.02 255 368020 42488 42210572
Hyperkinesia 19.88 11.02 51 368224 2047 42251013
Child abuse 19.85 11.02 31 368244 861 42252199
Apparent death 19.72 11.02 4 368271 3704 42249356
Pneumonia aspiration 19.68 11.02 309 367966 49769 42203291
Nicotine dependence 19.65 11.02 27 368248 666 42252394
Epileptic encephalopathy 19.63 11.02 18 368257 279 42252781
Vasculitis 19.54 11.02 244 368031 18150 42234910
Total lung capacity abnormal 19.39 11.02 83 368192 4360 42248700
Sexual dysfunction 19.31 11.02 18 368257 6757 42246303
Metamyelocyte count increased 19.31 11.02 22 368253 446 42252614
Shock 19.19 11.02 160 368115 28961 42224099
Left ventricular hypertrophy 19.08 11.02 142 368133 9177 42243883
Hepatocellular injury 19.05 11.02 299 367976 23379 42229681
Mania 19.04 11.02 39 368236 10508 42242552
Ventricular hypokinesia 19 11.02 113 368162 6771 42246289
Viral mutation identified 19.00 11.02 3 368272 3328 42249732
Pneumonia cytomegaloviral 18.96 11.02 6 368269 4120 42248940
Hyperreflexia 18.96 11.02 4 368271 3603 42249457
Clostridium difficile infection 18.95 11.02 288 367987 22371 42230689
Rhinitis perennial 18.95 11.02 15 368260 188 42252872
Injection site reaction 18.78 11.02 71 368204 15650 42237410
Serum ferritin abnormal 18.78 11.02 17 368258 259 42252801
Weight decreased 18.77 11.02 2062 366213 205886 42047174
Behaviour disorder 18.67 11.02 20 368255 7034 42246026
Spleen ischaemia 18.66 11.02 10 368265 60 42253000
Pulmonary sepsis 18.48 11.02 67 368208 3257 42249803
Psoriatic arthropathy 18.41 11.02 133 368142 24834 42228226
Ulnar nerve injury 18.33 11.02 12 368263 109 42252951
Exercise tolerance decreased 18.33 11.02 102 368173 5964 42247096
Bundle branch block left 18.32 11.02 107 368168 6369 42246691
Anaemia of malignant disease 18.32 11.02 23 368252 518 42252542
Splenic thrombosis 18.27 11.02 10 368265 63 42252997
Mean cell haemoglobin concentration 18.26 11.02 9 368266 44 42253016
Faeces pale 18.25 11.02 42 368233 1572 42251488
Drug dependence 18.22 11.02 162 368113 28932 42224128
Systemic lupus erythematosus 18.11 11.02 33 368242 9291 42243769
Anastomotic infection 18.06 11.02 12 368263 112 42252948
Device malfunction 17.96 11.02 51 368224 12276 42240784
Toxic epidermal necrolysis 17.95 11.02 328 367947 26422 42226638
Unintentional medical device removal 17.92 11.02 3 368272 3188 42249872
Physical examination abnormal 17.89 11.02 21 368254 440 42252620
Jaundice 17.88 11.02 408 367867 34181 42218879
Alveolar lung disease 17.86 11.02 21 368254 441 42252619
Duodenitis 17.85 11.02 95 368180 5461 42247599
Articular calcification 17.85 11.02 11 368264 89 42252971
Discontinued product administered 17.84 11.02 7 368268 17 42253043
Chest pain 17.76 11.02 1418 366857 138112 42114948
Gravitational oedema 17.74 11.02 26 368249 682 42252378
Cholelithiasis 17.73 11.02 292 367983 23054 42230006
Biliary cirrhosis 17.71 11.02 14 368261 175 42252885
Anaemia macrocytic 17.56 11.02 69 368206 3486 42249574
Liver disorder 17.54 11.02 239 368036 39405 42213655
Abdominal wall haemorrhage 17.51 11.02 22 368253 496 42252564
Abnormal faeces 17.49 11.02 74 368201 3867 42249193
Sleep disorder due to a general medical condition 17.48 11.02 229 368046 17224 42235836
Phalangeal hypoplasia 17.41 11.02 10 368265 70 42252990
Bronchial obstruction 17.40 11.02 43 368232 1686 42251374
Pulmonary toxicity 17.39 11.02 30 368245 8625 42244435
Scleroderma renal crisis 17.31 11.02 20 368255 412 42252648
Erectile dysfunction 17.28 11.02 135 368140 24778 42228282
Suture rupture 17.28 11.02 21 368254 457 42252603
Osteochondrosis 17.26 11.02 38 368237 1380 42251680
Adenovirus infection 17.26 11.02 20 368255 6789 42246271
Hepatitis B reactivation 17.23 11.02 9 368266 4569 42248491
Lymph nodes scan abnormal 17.11 11.02 8 368267 34 42253026
Ulcer haemorrhage 17.09 11.02 63 368212 3087 42249973
Flatulence 17.09 11.02 309 367966 24843 42228217
Procalcitonin abnormal 17.03 11.02 19 368256 376 42252684
Parosmia 17.02 11.02 25 368250 7666 42245394
Depressive symptom 17.01 11.02 6 368269 3847 42249213
Jugular vein distension 16.97 11.02 25 368250 659 42252401
Carotid artery stenosis 16.82 11.02 92 368183 5344 42247716
Activated partial thromboplastin time shortened 16.80 11.02 21 368254 471 42252589
Wound haemorrhage 16.79 11.02 51 368224 2260 42250800
Polyneuropathy 16.71 11.02 240 368035 18421 42234639
SARS-CoV-2 antibody test positive 16.68 11.02 19 368256 385 42252675
Multiple sclerosis relapse 16.67 11.02 65 368210 14199 42238861
Epidermolysis 16.66 11.02 21 368254 475 42252585
Asphyxia 16.60 11.02 29 368246 8297 42244763
Microvillous inclusion disease 16.59 11.02 15 368260 228 42252832
Cellulitis 16.59 11.02 405 367870 61180 42191880
Urticaria 16.54 11.02 500 367775 73536 42179524
Tachypnoea 16.48 11.02 271 368004 21391 42231669
Burns second degree 16.45 11.02 17 368258 6079 42246981
Base excess decreased 16.42 11.02 14 368261 196 42252864
Acute myocardial infarction 16.35 11.02 636 367639 57529 42195531
Cerebellar ischaemia 16.29 11.02 12 368263 134 42252926
Toxic skin eruption 16.28 11.02 186 368089 13544 42239516
Depression 16.27 11.02 791 367484 110572 42142488
Inspiratory capacity decreased 16.20 11.02 3 368272 2964 42250096
Chronic kidney disease-mineral and bone disorder 16.12 11.02 20 368255 445 42252615
Hypertrophy 16.10 11.02 21 368254 492 42252568
Blood pressure systolic abnormal 16.07 11.02 92 368183 5436 42247624
Cystitis haemorrhagic 16.04 11.02 24 368251 7305 42245755
Subacute cutaneous lupus erythematosus 16.04 11.02 38 368237 1450 42251610
Cryptococcosis 16.00 11.02 4 368271 3207 42249853
Salmonella bacteraemia 15.91 11.02 20 368255 451 42252609
Diverticulitis intestinal perforated 15.89 11.02 16 368259 280 42252780
Dry skin 15.87 11.02 308 367967 48030 42205030
Mood altered 15.87 11.02 44 368231 10674 42242386
Stenosis 15.86 11.02 47 368228 2054 42251006
Alopecia 15.81 11.02 169 368106 29107 42223953
Myoglobin blood increased 15.81 11.02 6 368269 3676 42249384
Saliva altered 15.80 11.02 14 368261 207 42252853
Hypertensive crisis 15.80 11.02 146 368129 10060 42243000
Nocardiosis 15.75 11.02 13 368262 5177 42247883
Periarthritis calcarea 15.73 11.02 10 368265 86 42252974
Sleep disorder therapy 15.66 11.02 22 368253 6872 42246188
Lymph node calcification 15.58 11.02 12 368263 144 42252916
Ischaemic nephropathy 15.54 11.02 10 368265 88 42252972
Intestinal obstruction 15.52 11.02 325 367950 26833 42226227
Incorrect dose administered 15.49 11.02 344 367931 52630 42200430
Graft versus host disease in gastrointestinal tract 15.46 11.02 13 368262 5130 42247930
Anger 15.42 11.02 59 368216 12959 42240101
Thrombophlebitis 15.36 11.02 71 368204 3855 42249205
Injection site phlebitis 15.30 11.02 7 368268 28 42253032
Bile duct stone 15.27 11.02 57 368218 2810 42250250
Cough 15.24 11.02 1760 366515 176343 42076717
Gastrointestinal pain 15.23 11.02 77 368198 4338 42248722
Allergic reaction to excipient 15.22 11.02 9 368266 67 42252993
Pulmonary valve incompetence 15.11 11.02 32 368243 1131 42251929
Headache 15.11 11.02 1824 366451 237545 42015515
Dependence on oxygen therapy 15.11 11.02 14 368261 220 42252840
Peripheral artery bypass 15 11.02 9 368266 69 42252991
Pulpitis dental 14.99 11.02 25 368250 735 42252325
Device dependence 14.93 11.02 8 368267 48 42253012
Ventriculo-peritoneal shunt 14.93 11.02 8 368267 48 42253012
Peripheral artery occlusion 14.90 11.02 42 368233 1784 42251276
Granulocytopenia 14.90 11.02 24 368251 7090 42245970
Device issue 14.88 11.02 63 368212 13446 42239614
Varicose vein 14.83 11.02 38 368237 1524 42251536
Benign gastrointestinal neoplasm 14.78 11.02 11 368264 125 42252935
Vision blurred 14.77 11.02 352 367923 53347 42199713
Gastrointestinal vascular malformation haemorrhagic 14.77 11.02 26 368249 799 42252261
Hepatitis 14.73 11.02 324 367951 26976 42226084
Meningitis cryptococcal 14.69 11.02 5 368270 3278 42249782
Cytomegalovirus chorioretinitis 14.69 11.02 11 368264 4600 42248460
Visual impairment 14.68 11.02 273 368002 42840 42210220
Psoriasis 14.68 11.02 314 367961 48290 42204770
Intention tremor 14.66 11.02 20 368255 490 42252570
Chondrocalcinosis 14.65 11.02 23 368252 642 42252418
Transfusion 14.60 11.02 147 368128 10367 42242693
Mydriasis 14.53 11.02 34 368241 8736 42244324
Blood iron decreased 14.52 11.02 99 368176 6219 42246841
Atypical pneumonia 14.52 11.02 72 368203 4025 42249035
Rectal prolapse 14.44 11.02 21 368254 547 42252513
Atrial enlargement 14.40 11.02 24 368251 705 42252355
Normochromic normocytic anaemia 14.39 11.02 130 368145 8901 42244159
Pruritus allergic 14.38 11.02 17 368258 359 42252701
Tendonitis 14.37 11.02 41 368234 9853 42243207
Arthropathy 14.36 11.02 175 368100 29422 42223638
Generalised tonic-clonic seizure 14.35 11.02 152 368123 26227 42226833
Cryptitis 14.31 11.02 15 368260 276 42252784
Idiopathic pulmonary fibrosis 14.30 11.02 78 368197 4526 42248534
Swollen tongue 14.29 11.02 116 368159 21115 42231945
Vanishing bile duct syndrome 14.27 11.02 42 368233 1829 42251231
Aortic dilatation 14.22 11.02 39 368236 1630 42251430
Cardiac discomfort 14.21 11.02 24 368251 713 42252347
Urine alcohol test positive 14.16 11.02 8 368267 54 42253006
Hyperkalaemia 14.16 11.02 840 367435 79618 42173442
Intraocular pressure increased 14.15 11.02 21 368254 6412 42246648
Pulmonary tuberculosis 14.11 11.02 16 368259 5485 42247575
Bradyarrhythmia 14.10 11.02 53 368222 2622 42250438
Pancreatic enzyme abnormality 14.08 11.02 10 368265 105 42252955
Neonatal respiratory distress syndrome 14.08 11.02 11 368264 4502 42248558
Vascular access site occlusion 14.05 11.02 8 368267 55 42253005
Abdominal discomfort 14.04 11.02 520 367755 74735 42178325
Renal cyst haemorrhage 14.01 11.02 23 368252 667 42252393
Hypertensive encephalopathy 14.00 11.02 19 368256 463 42252597
Adenocarcinoma gastric 13.99 11.02 35 368240 1383 42251677
Haematocrit decreased 13.99 11.02 398 367877 34510 42218550
Oesophageal candidiasis 13.98 11.02 90 368185 5545 42247515
Foetal growth restriction 13.96 11.02 15 368260 5268 42247792
Bronchiectasis 13.92 11.02 226 368049 17793 42235267
Acute generalised exanthematous pustulosis 13.84 11.02 124 368151 8471 42244589
Cardiac murmur 13.81 11.02 60 368215 12715 42240345
Disorientation 13.79 11.02 412 367863 35977 42217083
Dry eye 13.79 11.02 78 368197 15428 42237632
C-reactive protein abnormal 13.73 11.02 38 368237 9223 42243837
Hyperparathyroidism secondary 13.71 11.02 41 368234 1801 42251259
Lip squamous cell carcinoma 13.63 11.02 11 368264 142 42252918
Atrioventricular block 13.62 11.02 135 368140 9480 42243580
Inferior vena cava dilatation 13.61 11.02 25 368250 795 42252265
Rhythm idioventricular 13.57 11.02 16 368259 337 42252723
Atheroembolism 13.57 11.02 16 368259 337 42252723
Rebound effect 13.56 11.02 27 368248 7352 42245708
Renal fusion anomaly 13.55 11.02 9 368266 84 42252976
Duodenal ulcer 13.53 11.02 164 368111 12115 42240945
Hyperphosphataemia 13.50 11.02 62 368213 12942 42240118
Drug interaction 13.48 11.02 2560 365715 264439 41988621
Osteonecrosis 13.47 11.02 81 368194 15784 42237276
Renal phospholipidosis 13.44 11.02 11 368264 145 42252915
Perihepatic abscess 13.41 11.02 10 368265 114 42252946
Tetany 13.40 11.02 30 368245 1102 42251958
Mastitis 13.40 11.02 12 368263 180 42252880
Neurotoxicity 13.39 11.02 135 368140 23516 42229544
Hepatic cytolysis 13.37 11.02 315 367960 26529 42226531
Product quality issue 13.31 11.02 95 368180 17787 42235273
Accidental death 13.28 11.02 5 368270 3078 42249982
Dysmorphism 13.27 11.02 6 368269 3310 42249750
Diplopia 13.22 11.02 112 368163 20204 42232856
Impaired healing 13.21 11.02 214 368061 16839 42236221
Drug abuser 13.21 11.02 7 368268 3524 42249536
Adrenal cyst 13.19 11.02 12 368263 184 42252876
Deafness neurosensory 13.19 11.02 8 368267 3738 42249322
Intestinal angioedema 13.17 11.02 13 368262 222 42252838
Neonatal epileptic seizure 13.16 11.02 8 368267 63 42252997
Drug screen false positive 13.12 11.02 26 368249 876 42252184
Drug tolerance 13.10 11.02 6 368269 3284 42249776
Cachexia 13.09 11.02 117 368158 7987 42245073
Hypoaesthesia 13.06 11.02 495 367780 70968 42182092
Priapism 13.06 11.02 22 368253 6385 42246675
Helicobacter test false negative 13.06 11.02 8 368267 64 42252996
Actinic keratosis 13.05 11.02 83 368192 5093 42247967
Heart rate irregular 13.04 11.02 203 368072 15847 42237213
Phlebitis infective 12.99 11.02 10 368265 120 42252940
Peripheral paralysis 12.92 11.02 6 368269 25 42253035
Internal fixation of fracture 12.87 11.02 9 368266 92 42252968
Plasma cell myeloma 12.84 11.02 518 367757 47060 42206000
Acute coronary syndrome 12.84 11.02 190 368085 14675 42238385
Ocular icterus 12.82 11.02 57 368218 3044 42250016
Lumbar vertebral fracture 12.82 11.02 58 368217 3121 42249939
Paresis 12.78 11.02 49 368226 2447 42250613
Analgesic therapy 12.75 11.02 23 368252 6501 42246559
Pulmonary vascular disorder 12.73 11.02 22 368253 666 42252394
Fungal infection 12.71 11.02 109 368166 19613 42233447
Meralgia paraesthetica 12.67 11.02 11 368264 158 42252902
Hypergammaglobulinaemia 12.62 11.02 16 368259 364 42252696
Poisoning deliberate 12.61 11.02 45 368230 10089 42242971
Rectal abscess 12.60 11.02 38 368237 1677 42251383
Strongyloidiasis 12.54 11.02 7 368268 3424 42249636
Dust allergy 12.53 11.02 84 368191 5248 42247812
Exposure via breast milk 12.51 11.02 3 368272 2474 42250586
Occupational exposure to air contaminants 12.51 11.02 11 368264 161 42252899
Metastatic malignant melanoma 12.49 11.02 47 368228 2326 42250734
Hypovolaemic shock 12.47 11.02 122 368153 8537 42244523
Tuberculosis 12.46 11.02 45 368230 10054 42243006
N-terminal prohormone brain natriuretic peptide increased 12.46 11.02 61 368214 3392 42249668
Nuchal rigidity 12.45 11.02 19 368256 517 42252543
Xyphoid retraction 12.45 11.02 11 368264 162 42252898
Sinus arrest 12.45 11.02 44 368231 2112 42250948
Maternal drugs affecting foetus 12.43 11.02 9 368266 3830 42249230
Infusion site haematoma 12.39 11.02 6 368269 28 42253032
Euphoric mood 12.39 11.02 23 368252 6430 42246630
Cognitive disorder 12.39 11.02 214 368061 33958 42219102
Arteriosclerotic gangrene 12.37 11.02 8 368267 71 42252989
Dyskinesia 12.36 11.02 150 368125 25240 42227820
Neuralgia 12.31 11.02 152 368123 25495 42227565
SARS-CoV-2 sepsis 12.28 11.02 13 368262 242 42252818
Epstein-Barr virus associated lymphoproliferative disorder 12.26 11.02 3 368272 2440 42250620
Organic brain syndrome 12.25 11.02 15 368260 329 42252731
Vena cava injury 12.25 11.02 15 368260 329 42252731
Paranoia 12.23 11.02 71 368204 13955 42239105
Akinesia 12.23 11.02 48 368227 2424 42250636
Abnormal dreams 12.21 11.02 34 368241 8237 42244823
Embedded device 12.20 11.02 17 368258 425 42252635
Intraventricular haemorrhage 12.20 11.02 66 368209 3818 42249242
Swelling 12.17 11.02 371 367904 54514 42198546
Vascular compression 12.17 11.02 16 368259 378 42252682
Eye injury 12.15 11.02 27 368248 987 42252073
Miller Fisher syndrome 12.15 11.02 10 368265 133 42252927
Increased appetite 12.14 11.02 38 368237 8868 42244192
Discoloured vomit 12.14 11.02 23 368252 749 42252311
COVID-19 pneumonia 12.14 11.02 258 368017 21355 42231705
Left ventricular enlargement 12.12 11.02 24 368251 808 42252252
Hyperferritinaemia 12.11 11.02 20 368255 583 42252477
Obsessive-compulsive disorder 12.11 11.02 25 368250 6718 42246342
Delusion 12.11 11.02 76 368199 14658 42238402
FEV1/FVC ratio decreased 12.09 11.02 10 368265 134 42252926
Colitis ulcerative 12.08 11.02 304 367971 25871 42227189
Leukoencephalopathy 12.08 11.02 15 368260 4939 42248121
Bradycardia 12.07 11.02 876 367399 84608 42168452
Mixed liver injury 12.07 11.02 73 368202 4401 42248659
Total lung capacity decreased 12.05 11.02 8 368267 3562 42249498
Dermatosis 12.04 11.02 16 368259 382 42252678
Puncture site haematoma 12.02 11.02 11 368264 170 42252890
Rales 12.01 11.02 151 368124 11249 42241811
Renal cancer 12.00 11.02 34 368241 8190 42244870
Urinary straining 12.00 11.02 5 368270 15 42253045
Malignant neoplasm progression 11.99 11.02 791 367484 107609 42145451
Arteriovenous fistula 11.97 11.02 29 368246 1123 42251937
Haemorrhoids 11.95 11.02 211 368064 16886 42236174
Nasal oedema 11.94 11.02 15 368260 338 42252722
Procalcitonin increased 11.92 11.02 45 368230 2231 42250829
Mean cell volume increased 11.88 11.02 66 368209 3857 42249203
Acute graft versus host disease in intestine 11.86 11.02 10 368265 3941 42249119
Cardiac ablation 11.86 11.02 31 368244 1259 42251801
Lung neoplasm malignant 11.82 11.02 107 368168 19040 42234020
Brain stem ischaemia 11.82 11.02 11 368264 174 42252886
Electrocardiogram QT prolonged 11.81 11.02 517 367758 47428 42205632
Product administered at inappropriate site 11.80 11.02 6 368269 3092 42249968
Ocular hyperaemia 11.79 11.02 85 368190 15878 42237182
Pancreatic duct stenosis 11.77 11.02 11 368264 175 42252885
Miosis 11.76 11.02 68 368207 13378 42239682
Pericardial calcification 11.76 11.02 6 368269 32 42253028
Pulmonary interstitial emphysema syndrome 11.75 11.02 19 368256 544 42252516
Vascular anastomotic haemorrhage 11.72 11.02 14 368261 299 42252761
Large intestine polyp 11.67 11.02 127 368148 9138 42243922
Anti factor V antibody 11.65 11.02 14 368261 301 42252759
Dysphagia 11.64 11.02 753 367522 71966 42181094
Hemiparesis 11.64 11.02 213 368062 17163 42235897
Blood thyroid stimulating hormone increased 11.62 11.02 82 368193 5210 42247850
Tearfulness 11.60 11.02 8 368267 3492 42249568
Tumour pain 11.60 11.02 31 368244 1276 42251784
Renal failure 11.58 11.02 1415 366860 142311 42110749
Lipoprotein (a) increased 11.58 11.02 15 368260 349 42252711
Cutaneous vasculitis 11.58 11.02 100 368175 6760 42246300
PCO2 decreased 11.58 11.02 38 368237 1756 42251304
Brain oedema 11.55 11.02 88 368187 16239 42236821
Troponin increased 11.51 11.02 230 368045 18832 42234228
Disseminated tuberculosis 11.48 11.02 5 368270 2819 42250241
Bacteroides infection 11.47 11.02 4 368271 2583 42250477
Pericardial haemorrhage 11.45 11.02 61 368214 3508 42249552
Congestive cardiomyopathy 11.44 11.02 121 368154 8643 42244417
Febrile neutropenia 11.38 11.02 1799 366476 183904 42069156
Tubulointerstitial nephritis 11.37 11.02 355 367920 31193 42221867
Diabetic gastroparesis 11.36 11.02 9 368266 113 42252947
Lower respiratory tract congestion 11.34 11.02 35 368240 1565 42251495
Cardiovascular somatic symptom disorder 11.33 11.02 6 368269 35 42253025
Autoimmune hypothyroidism 11.32 11.02 11 368264 184 42252876
Band neutrophil count decreased 11.28 11.02 3 368272 0 42253060
Fibrin D dimer 11.28 11.02 3 368272 0 42253060
Achlorhydria 11.28 11.02 3 368272 0 42253060
Subcapsular hepatic haematoma 11.28 11.02 3 368272 0 42253060
Spinal cord herniation 11.28 11.02 3 368272 0 42253060
Blood alcohol abnormal 11.28 11.02 3 368272 0 42253060
Peripheral venous disease 11.22 11.02 54 368221 2982 42250078
Vascular shunt 11.20 11.02 6 368269 36 42253024
Leptotrichia infection 11.19 11.02 8 368267 85 42252975
Inappropriate antidiuretic hormone secretion 11.16 11.02 203 368072 16338 42236722
Echocardiogram abnormal 11.15 11.02 30 368245 1240 42251820
Thoracic vertebral fracture 11.14 11.02 45 368230 2303 42250757
Oral pruritus 11.12 11.02 18 368257 516 42252544
Cushingoid 11.11 11.02 8 368267 3414 42249646
Polypectomy 11.11 11.02 20 368255 626 42252434
Speech disorder developmental 11.09 11.02 3 368272 2282 42250778
Confabulation 11.06 11.02 10 368265 152 42252908

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1429.03 10.25 7531 980176 417764 109183828
Toxicity to various agents 1154.93 10.25 1562 986145 478993 109122599
Completed suicide 961.69 10.25 481 987226 241900 109359692
Drug ineffective 943.14 10.25 8871 978836 1511669 108089923
Hypomagnesaemia 595.01 10.25 1520 986187 58850 109542742
Product prescribing error 505.43 10.25 1292 986415 50039 109551553
Drug abuse 504.94 10.25 503 987204 176908 109424684
Systemic infection 472.14 10.25 508 987199 9311 109592281
Haematochezia 447.75 10.25 2132 985575 113392 109488200
Anaemia 416.59 10.25 7032 980675 540054 109061538
Hypocalcaemia 345.06 10.25 1325 986382 64041 109537551
Off label use 344.26 10.25 10496 977211 1489689 108111903
Intentional overdose 341.24 10.25 408 987299 132093 109469499
Myelosuppression 312.84 10.25 231 987476 94109 109507483
Injection site reaction 294.19 10.25 219 987488 88851 109512741
Chronic kidney disease 273.41 10.25 1377 986330 74914 109526678
Death 258.65 10.25 4538 983169 694331 108907261
Drug resistance 251.82 10.25 94 987613 56280 109545312
Product monitoring error 232.87 10.25 340 987367 8587 109593005
Acute kidney injury 227.03 10.25 7349 980358 628081 108973511
Hepatic function abnormal 218.36 10.25 286 987421 89009 109512583
Product use in unapproved indication 212.34 10.25 2768 984939 444609 109156983
Device expulsion 208.80 10.25 18 987689 30873 109570719
Hypokalaemia 199.07 10.25 2498 985209 179950 109421642
Disease progression 196.46 10.25 1323 986384 242711 109358881
Product dose omission issue 195.70 10.25 1882 985825 319900 109281692
Overdose 188.94 10.25 1266 986441 232528 109369064
Rheumatoid arthritis 186.94 10.25 3735 983972 295878 109305714
Melaena 182.59 10.25 1145 986562 67612 109533980
Injection site pain 179.37 10.25 897 986810 177025 109424567
Dyspnoea 178.25 10.25 11811 975896 1095061 108506531
Abdominal pain 178.18 10.25 5914 981793 507075 109094517
Hyponatraemia 174.93 10.25 2824 984883 214829 109386763
Agranulocytosis 173.79 10.25 1044 986663 60716 109540876
Labelled drug-drug interaction medication error 172.23 10.25 615 987092 28687 109572905
Injection site erythema 169.85 10.25 367 987340 93809 109507783
Abdominal pain upper 169.44 10.25 4199 983508 344912 109256680
Haematemesis 168.77 10.25 1003 986704 58105 109543487
Sedation 168.52 10.25 225 987482 69458 109532134
Electrolyte imbalance 167.08 10.25 715 986992 36313 109565279
Cholestasis 158.79 10.25 1054 986653 63464 109538128
Neuropathy peripheral 153.38 10.25 954 986753 178323 109423269
Exposure during pregnancy 147.90 10.25 882 986825 166542 109435050
Onychomycosis 147.45 10.25 80 987627 38451 109563141
Drug ineffective for unapproved indication 139.81 10.25 461 987246 102377 109499215
Asthenia 138.30 10.25 7499 980208 681500 108920092
Respiratory arrest 135.21 10.25 194 987513 58105 109543487
Therapy partial responder 125.13 10.25 89 987618 36972 109564620
Neutrophil count decreased 124.60 10.25 605 987102 120336 109481256
Eosinophilia 121.26 10.25 910 986797 57026 109544566
Intentional product misuse 121.19 10.25 693 987014 132211 109469381
Sleep disorder due to general medical condition, insomnia type 120.18 10.25 1458 986249 104185 109497407
White blood cell count decreased 117.44 10.25 1396 986311 227994 109373598
Drug use disorder 115.69 10.25 13 987694 18061 109583531
Oedema peripheral 111.91 10.25 3781 983926 324879 109276713
Cytomegalovirus infection 107.73 10.25 201 987506 54243 109547349
Abdominal pain lower 106.01 10.25 632 987075 36651 109564941
Wrong technique in product usage process 105.80 10.25 411 987296 86937 109514655
Cardio-respiratory arrest 105.07 10.25 605 987102 115231 109486361
Accidental exposure to product 104.92 10.25 178 987529 49830 109551762
Muscle injury 104.64 10.25 1804 985903 139003 109462589
Atrial fibrillation 103.67 10.25 2736 984971 226906 109374686
Suicide attempt 102.62 10.25 524 987183 102870 109498722
Syncope 101.75 10.25 2448 985259 200088 109401504
Platelet count decreased 101.19 10.25 1448 986259 228995 109372597
Blood loss anaemia 100.59 10.25 372 987335 17653 109583939
Gastrointestinal haemorrhage 97.08 10.25 2045 985662 163473 109438119
Cardiac arrest 97.04 10.25 1207 986500 195546 109406046
Irritable bowel syndrome 96.67 10.25 2030 985677 162185 109439407
Abortion spontaneous 96.56 10.25 98 987609 34184 109567408
Sedation complication 95.83 10.25 29 987678 19826 109581766
Post transplant lymphoproliferative disorder 95.61 10.25 13 987694 15600 109585992
Leukopenia 95.44 10.25 1863 985844 146928 109454664
Therapeutic drug monitoring analysis not performed 94.77 10.25 101 987606 1830 109599762
Injection site swelling 93.99 10.25 263 987444 61527 109540065
Hepatitis cholestatic 89.36 10.25 352 987355 17214 109584378
Somnolence 89.02 10.25 2000 985707 295449 109306143
Injection site pruritus 88.13 10.25 205 987502 51053 109550539
Product label confusion 86.89 10.25 47 987660 22630 109578962
Drug hypersensitivity 86.69 10.25 3248 984459 450842 109150750
Gastritis 85.93 10.25 794 986913 52905 109548687
Irritability 84.80 10.25 188 987519 47621 109553971
Dyspnoea exertional 84.23 10.25 1352 986355 102708 109498884
Adverse reaction 84.04 10.25 84 987623 29510 109572082
Muscle spasticity 83.75 10.25 579 987128 35336 109566256
Impaired healing 83.44 10.25 2325 985382 194392 109407200
Intentional self-injury 83.43 10.25 128 987579 37301 109564291
Treatment failure 82.98 10.25 1864 985843 275370 109326222
Finger deformity 81.91 10.25 105 987602 32987 109568605
Angina pectoris 80.35 10.25 881 986826 61414 109540178
Suicidal ideation 80.25 10.25 500 987207 93437 109508155
Premature delivery 79.18 10.25 94 987613 30538 109571054
Subacute cutaneous lupus erythematosus 78.97 10.25 152 987555 4842 109596750
Anaphylactic reaction 78.86 10.25 647 987060 113653 109487939
Clostridium test positive 78.58 10.25 245 987462 10648 109590944
Seizure 78.14 10.25 1447 986260 219738 109381854
Pathogen resistance 78.03 10.25 30 987677 17642 109583950
Hypoparathyroidism secondary 77.74 10.25 42 987665 247 109601345
Rash maculo-papular 76.58 10.25 1006 986701 73216 109528376
No adverse event 76.26 10.25 369 987338 73470 109528122
Febrile infection 76.08 10.25 140 987567 4308 109597284
Serotonin syndrome 75.77 10.25 272 987435 58881 109542711
Orthostatic intolerance 74.82 10.25 94 987613 2047 109599545
Abnormal behaviour 74.73 10.25 147 987560 38892 109562700
Multiple-drug resistance 74.34 10.25 14 987693 13221 109588371
Acute abdomen 73.55 10.25 118 987589 3243 109598349
Musculoskeletal pain 73.43 10.25 2148 985559 180875 109420717
Therapeutic response decreased 73.25 10.25 532 987175 95967 109505625
Drug dependence 73.08 10.25 217 987490 49803 109551789
Nightmare 72.96 10.25 148 987559 38715 109562877
Injection site haemorrhage 72.62 10.25 114 987593 32914 109568678
Asthma 72.57 10.25 2828 984879 247463 109354129
Tubulointerstitial nephritis 70.15 10.25 768 986939 53516 109548076
Exposure to toxic agent 69.31 10.25 15 987692 12843 109588749
Thrombocytopenia 69.16 10.25 3794 983913 345091 109256501
Onychomadesis 68.97 10.25 195 987512 45468 109556124
Acute graft versus host disease 67.49 10.25 16 987691 12865 109588727
Feeling abnormal 67.05 10.25 1172 986535 179539 109422053
Contusion 67.02 10.25 2634 985073 230727 109370865
Obstructive airways disorder 66.75 10.25 668 987039 45481 109556111
Coma 65.53 10.25 704 987003 117165 109484427
Mydriasis 65.11 10.25 61 987646 22096 109579496
Device difficult to use 65.02 10.25 44 987663 18761 109582831
Dehydration 64.47 10.25 3084 984623 276427 109325165
Enthesopathy 64.39 10.25 16 987691 12462 109589130
Upper gastrointestinal haemorrhage 64.39 10.25 708 986999 49388 109552204
Diastolic dysfunction 62.64 10.25 248 987459 12156 109589436
Drug reaction with eosinophilia and systemic symptoms 62.50 10.25 1056 986651 81039 109520553
Cellulitis 61.77 10.25 774 986933 125242 109476350
Benign prostatic hyperplasia 61.74 10.25 324 987383 17910 109583682
Flushing 61.72 10.25 617 987090 104119 109497473
Erysipelas 61.63 10.25 257 987450 12901 109588691
Cardiac failure 61.41 10.25 2149 985558 185477 109416115
Dissociation 60.73 10.25 8 987699 9834 109591758
Malaise 60.19 10.25 5173 982534 666646 108934946
Appendicitis 60.00 10.25 101 987606 28363 109573229
Colitis ulcerative 59.95 10.25 998 986709 76365 109525227
Steroid dependence 59.88 10.25 4 987703 8465 109593127
Cytomegalovirus viraemia 59.52 10.25 43 987664 17721 109583871
Renal injury 58.95 10.25 326 987381 18387 109583205
Pallor 58.94 10.25 767 986940 55700 109545892
Drug dose omission by device 58.74 10.25 28 987679 14488 109587104
Psychotic disorder 58.33 10.25 245 987462 50692 109550900
Unintentional medical device removal 58.18 10.25 6 987701 8917 109592675
Poisoning deliberate 57.78 10.25 91 987616 26240 109575352
Blood pressure systolic increased 57.28 10.25 1051 986656 81940 109519652
Injection site bruising 57.21 10.25 249 987458 51014 109550578
Product storage error 56.89 10.25 66 987641 21662 109579930
Disseminated intravascular coagulation 56.85 10.25 184 987523 41102 109560490
Sinusitis 56.75 10.25 3216 984491 293472 109308120
Vision blurred 56.51 10.25 811 986896 128211 109473381
Hypoparathyroidism 56.40 10.25 69 987638 1461 109600131
Epstein-Barr virus infection 55.76 10.25 51 987656 18687 109582905
Haematoma 54.77 10.25 779 986928 57697 109543895
Cytomegalovirus infection reactivation 54.43 10.25 50 987657 18283 109583309
Pneumonia aspiration 53.70 10.25 465 987242 80768 109520824
Cachexia 53.27 10.25 244 987463 12761 109588831
Body temperature decreased 53.11 10.25 534 987173 36401 109565191
Substance use disorder 52.88 10.25 3 987704 7287 109594305
Device issue 52.51 10.25 147 987560 34388 109567204
Fluid intake reduced 52.13 10.25 159 987548 6827 109594765
Folliculitis 52.10 10.25 1909 985798 165744 109435848
Extrapyramidal disorder 51.62 10.25 113 987594 28754 109572838
Tinnitus 51.31 10.25 323 987384 60217 109541375
Cerebral infarction 50.70 10.25 264 987443 51574 109550018
Temperature regulation disorder 49.87 10.25 237 987470 12589 109589003
Shock 49.60 10.25 278 987429 53310 109548282
Ear pain 49.43 10.25 708 986999 52518 109549074
Shock haemorrhagic 49.35 10.25 414 987293 26833 109574759
Night sweats 49.31 10.25 1556 986151 132427 109469165
Peripheral swelling 48.98 10.25 4218 983489 399816 109201776
Pneumonia salmonella 48.78 10.25 21 987686 67 109601525
Interstitial lung disease 48.73 10.25 913 986794 138421 109463171
Presyncope 48.52 10.25 658 987049 48229 109553363
Tricuspid valve incompetence 48.28 10.25 372 987335 23501 109578091
Device use error 48.19 10.25 11 987696 9078 109592514
Hiatus hernia 48.18 10.25 416 987291 27190 109574402
Bronchopulmonary aspergillosis 47.75 10.25 124 987583 29739 109571853
Faecaloma 47.15 10.25 260 987447 14648 109586944
Aortic valve stenosis 46.90 10.25 144 987563 6206 109595386
Right atrial hypertrophy 46.65 10.25 43 987664 648 109600944
Urogenital haemorrhage 46.57 10.25 50 987657 914 109600678
Poisoning 46.43 10.25 121 987586 28984 109572608
Depressed level of consciousness 46.32 10.25 714 986993 111564 109490028
Rectal haemorrhage 46.04 10.25 1399 986308 118434 109483158
Tachyarrhythmia 45.68 10.25 170 987537 8091 109593501
Bladder cancer 45.61 10.25 69 987638 20223 109581369
Dyspnoea at rest 45.53 10.25 171 987536 8175 109593417
Maternal exposure during pregnancy 45.33 10.25 1838 985869 253045 109348547
Iron deficiency anaemia 45.25 10.25 456 987251 31103 109570489
Diverticulum intestinal 45.17 10.25 216 987491 11503 109590089
Photodermatosis 44.82 10.25 52 987655 1039 109600553
Neuroleptic malignant syndrome 44.70 10.25 155 987552 33904 109567688
Gamma-glutamyltransferase increased 44.63 10.25 783 986924 60526 109541066
Acute graft versus host disease in skin 44.57 10.25 20 987687 10720 109590872
Withdrawal syndrome 44.50 10.25 138 987569 31242 109570350
Nail disorder 44.16 10.25 319 987388 57616 109543976
Drug effective for unapproved indication 44.04 10.25 37 987670 14130 109587462
Gastritis erosive 43.97 10.25 218 987489 11782 109589810
Balance disorder 43.85 10.25 754 986953 115806 109485786
Treatment noncompliance 43.84 10.25 428 987279 72562 109529030
Blood pressure increased 43.62 10.25 2770 984937 255603 109345989
Drug withdrawal syndrome 43.59 10.25 183 987524 37871 109563721
Chronic graft versus host disease 43.54 10.25 15 987692 9442 109592150
Therapeutic product effect incomplete 43.50 10.25 1597 986110 222208 109379384
Blood pressure diastolic abnormal 43.49 10.25 386 987321 25429 109576163
Breath sounds abnormal 43.39 10.25 381 987326 25023 109576569
Haematotoxicity 43.35 10.25 76 987631 21006 109580586
Adenovirus infection 43.29 10.25 22 987685 10972 109590620
Gastrointestinal disorder 43.26 10.25 2607 985100 239345 109362247
Prostate cancer 43.13 10.25 181 987526 37460 109564132
Pre-eclampsia 42.91 10.25 12 987695 8638 109592954
Catarrh 42.86 10.25 7 987700 7328 109594264
Depression 42.76 10.25 2357 985350 314978 109286614
Hypomania 42.39 10.25 19 987688 10191 109591401
Blister 42.37 10.25 2459 985248 224917 109376675
Cardiotoxicity 42.37 10.25 53 987654 16828 109584764
BK virus infection 42.28 10.25 33 987674 13073 109588519
Confusional state 42.22 10.25 4793 982914 463887 109137705
Lung diffusion test abnormal 42.09 10.25 32 987675 363 109601229
Pyrexia 41.81 10.25 8852 978855 889413 108712179
Sleep terror 41.69 10.25 5 987702 6605 109594987
Fracture 41.43 10.25 370 987337 24418 109577174
Haemoglobin decreased 41.33 10.25 2663 985044 246064 109355528
Blood phosphorus increased 41.32 10.25 51 987656 16289 109585303
Multiple organ dysfunction syndrome 41.22 10.25 1035 986672 150675 109450917
Full blood count abnormal 41.21 10.25 717 986990 55335 109546257
Dry skin 40.95 10.25 695 987012 106958 109494634
Sickle cell anaemia with crisis 40.84 10.25 17 987690 9528 109592064
Drug intolerance 40.49 10.25 3103 984604 403409 109198183
Accidental overdose 40.19 10.25 284 987423 51550 109550042
Urosepsis 40.10 10.25 435 987272 30240 109571352
Neck pain 39.97 10.25 817 986890 122313 109479279
Foetal exposure during pregnancy 39.96 10.25 9 987698 7496 109594096
Dysuria 39.91 10.25 758 986949 59473 109542119
Glomerular filtration rate decreased 39.90 10.25 415 987292 28541 109573051
End stage renal disease 39.81 10.25 328 987379 21145 109580447
Clostridium difficile colitis 39.73 10.25 580 987127 43198 109558394
Caesarean section 39.48 10.25 39 987668 13778 109587814
Adjustment disorder 39.47 10.25 196 987511 10599 109590993
Device malfunction 39.45 10.25 108 987599 25450 109576142
Alanine aminotransferase abnormal 39.34 10.25 17 987690 9317 109592275
Weight increased 39.22 10.25 4302 983405 415342 109186250
Injection site urticaria 39.21 10.25 58 987649 17157 109584435
Dystonia 39.12 10.25 110 987597 25695 109575897
Food allergy 38.23 10.25 307 987400 19641 109581951
Breast cancer female 38.22 10.25 33 987674 12435 109589157
Lower respiratory tract infection 38.10 10.25 2590 985117 240516 109361076
Status epilepticus 37.94 10.25 149 987558 31422 109570170
Productive cough 37.83 10.25 1311 986396 112994 109488598
Hypertensive crisis 37.80 10.25 358 987349 24014 109577578
Transplant rejection 37.78 10.25 104 987603 24463 109577129
Neutropenic sepsis 37.66 10.25 144 987563 30602 109570990
Inappropriate antidiuretic hormone secretion 37.53 10.25 465 987242 33386 109568206
Rash 37.49 10.25 6606 981101 814358 108787234
Asphyxia 37.41 10.25 43 987664 14172 109587420
Eye pruritus 37.31 10.25 158 987549 32617 109568975
Lethargy 37.27 10.25 599 987108 92977 109508615
Breast cancer stage I 37.11 10.25 10 987697 7377 109594215
Substance abuse 36.99 10.25 34 987673 12429 109589163
Ventricular fibrillation 36.80 10.25 217 987490 41096 109560496
Urinary hesitation 36.63 10.25 108 987599 4550 109597042
Device leakage 36.62 10.25 54 987653 15994 109585598
Mucormycosis 36.57 10.25 25 987682 10603 109590989
Infection 36.50 10.25 3732 983975 358468 109243124
Graft versus host disease in skin 36.46 10.25 14 987693 8240 109593352
Hydrocholecystis 36.19 10.25 35 987672 562 109601030
Hypoaesthesia 36.11 10.25 2369 985338 311854 109289738
Blood pressure systolic abnormal 36.08 10.25 360 987347 24490 109577102
Hyperkinesia 35.42 10.25 84 987623 3100 109598492
Injection site rash 35.37 10.25 100 987607 23319 109578273
Therapy non-responder 35.35 10.25 1102 986605 156205 109445387
Mood swings 34.76 10.25 97 987610 22715 109578877
Immune reconstitution inflammatory syndrome 34.74 10.25 57 987650 16169 109585423
Osteonecrosis 34.61 10.25 169 987538 33572 109568020
Haematuria 34.60 10.25 979 986728 82026 109519566
Creatinine renal clearance decreased 34.56 10.25 91 987616 21724 109579868
Jaundice 34.42 10.25 731 986976 58505 109543087
Duodenitis 34.36 10.25 168 987539 9028 109592564
Palmoplantar keratoderma 34.17 10.25 4 987703 5383 109596209
Hepatic cyst 34.12 10.25 149 987558 7634 109593958
Gastric ulcer 33.94 10.25 522 987185 39305 109562287
Paradoxical drug reaction 33.90 10.25 23 987684 9794 109591798
Hypopnoea 33.83 10.25 31 987676 11349 109590243
Agitation 33.82 10.25 760 986947 112291 109489301
Weight decreased 33.81 10.25 4722 982985 463335 109138257
Hypertensive nephropathy 33.79 10.25 44 987663 994 109600598
Body temperature increased 33.70 10.25 681 987026 54032 109547560
Gastrointestinal angiodysplasia 33.53 10.25 48 987659 1190 109600402
Clostridium difficile infection 33.50 10.25 653 987054 51476 109550116
Flatulence 33.43 10.25 653 987054 51496 109550096
Posterior reversible encephalopathy syndrome 33.37 10.25 172 987535 33689 109567903
Exercise tolerance decreased 33.31 10.25 203 987504 11864 109589728
Pancreatic steatosis 33.27 10.25 59 987648 1763 109599829
Lactic acidosis 33.14 10.25 1074 986633 91737 109509855
Uterine perforation 32.99 10.25 10 987697 6830 109594762
Serum ferritin decreased 32.97 10.25 79 987628 2935 109598657
Drug eruption 32.92 10.25 313 987394 53346 109548246
Rebound acid hypersecretion 32.76 10.25 18 987689 110 109601482
Alcohol poisoning 32.70 10.25 20 987687 9000 109592592
Lip swelling 32.62 10.25 292 987415 50375 109551217
Visual acuity reduced 32.51 10.25 162 987545 32011 109569581
Bacterial infection 32.47 10.25 259 987448 45777 109555815
Congenital hiatus hernia 32.30 10.25 126 987581 6133 109595459
Ill-defined disorder 32.29 10.25 1712 985995 155141 109446451
Carotid arteriosclerosis 32.24 10.25 79 987628 2978 109598614
Sexual dysfunction 32.22 10.25 18 987689 8512 109593080
Multiple sclerosis relapse 32.14 10.25 290 987417 49950 109551642
Aggression 31.96 10.25 356 987351 58854 109542738
Epstein-Barr virus associated lymphoproliferative disorder 31.91 10.25 3 987704 4799 109596793
Renal cyst 31.80 10.25 274 987433 17898 109583694
Heart rate decreased 31.75 10.25 966 986741 81790 109519802
Thrombotic microangiopathy 31.67 10.25 143 987564 29006 109572586
Normocytic anaemia 31.62 10.25 128 987579 6339 109595253
Hepatocellular injury 31.41 10.25 631 987076 50011 109551581
Discontinued product administered 31.33 10.25 17 987690 101 109601491
Stress 31.29 10.25 709 986998 104639 109496953
Oesophageal carcinoma 31.27 10.25 34 987673 11490 109590102
Injection site warmth 31.23 10.25 68 987639 17337 109584255
Bicytopenia 31.23 10.25 131 987576 6593 109594999
Pulmonary fibrosis 31.22 10.25 1160 986547 100882 109500710
Trimethylaminuria 31.15 10.25 21 987686 194 109601398
Diarrhoea 30.96 10.25 10977 976730 1128528 108473064
Respiratory disorder 30.90 10.25 846 986861 70536 109531056
Genital haemorrhage 30.90 10.25 13 987694 7239 109594353
Helicobacter infection 30.88 10.25 1951 985756 179926 109421666
Polyneuropathy 30.60 10.25 428 987279 31584 109570008
Akathisia 30.59 10.25 67 987640 17046 109584546
Lung neoplasm malignant 30.55 10.25 177 987530 33665 109567927
Premature rupture of membranes 30.54 10.25 3 987704 4634 109596958
Lower gastrointestinal haemorrhage 30.41 10.25 275 987432 18211 109583381
Autoimmune disorder 30.33 10.25 783 986924 64700 109536892
Hallucination 30.31 10.25 682 987025 100750 109500842
Hyperammonaemic encephalopathy 29.99 10.25 6 987701 5428 109596164
Gastrointestinal pain 29.93 10.25 195 987512 11665 109589927
Disease recurrence 29.90 10.25 373 987334 60411 109541181
Hypochromic anaemia 29.89 10.25 79 987628 3122 109598470
Coagulation test abnormal 29.79 10.25 52 987655 1534 109600058
Electrocardiogram T wave alternans 29.77 10.25 18 987689 135 109601457
Vitamin B12 decreased 29.76 10.25 109 987598 5148 109596444
Sputum discoloured 29.76 10.25 381 987326 27564 109574028
Mucosal haemorrhage 29.70 10.25 76 987631 2944 109598648
Mitral valve incompetence 29.63 10.25 440 987267 32889 109568703
Microcytic anaemia 29.55 10.25 122 987585 6096 109595496
Altered state of consciousness 29.34 10.25 351 987356 57275 109544317
Pancreatitis 29.04 10.25 1065 986642 92468 109509124
Anaphylactic shock 28.99 10.25 307 987400 51239 109550353
Diffuse large B-cell lymphoma recurrent 28.99 10.25 10 987697 6289 109595303
Malignant neoplasm progression 28.88 10.25 1269 986438 173298 109428294
Discomfort 28.79 10.25 2259 985448 212448 109389144
Pneumonia cytomegaloviral 28.78 10.25 13 987694 6941 109594651
Gestational diabetes 28.77 10.25 15 987692 7374 109594218
Impaired quality of life 28.72 10.25 154 987553 29863 109571729
Gingival pain 28.63 10.25 61 987646 15675 109585917
Pulmonary tuberculosis 28.25 10.25 24 987683 9115 109592477
Abnormal dreams 28.20 10.25 44 987663 12736 109588856
Throat clearing 28.12 10.25 94 987613 4239 109597353
Infective exacerbation of chronic obstructive airways disease 28.05 10.25 77 987630 3113 109598479
Soft tissue disorder 28.00 10.25 82 987625 3442 109598150
Exposure via ingestion 27.92 10.25 5 987702 4895 109596697
Graft versus host disease 27.89 10.25 81 987626 18725 109582867
Paresis 27.89 10.25 101 987606 4743 109596849
Hepatic enzyme increased 27.71 10.25 3273 984434 317619 109283973
Painful respiration 27.70 10.25 85 987622 3662 109597930
Breast cancer 27.58 10.25 216 987491 38326 109563266
Miosis 27.55 10.25 102 987605 21881 109579711
Pain in jaw 27.51 10.25 308 987399 50869 109550723
Rhinitis allergic 27.46 10.25 76 987631 17846 109583746
Dermatitis exfoliative generalised 27.45 10.25 180 987527 10792 109590800
Solar lentigo 27.38 10.25 49 987658 1475 109600117
Subileus 27.29 10.25 122 987585 6315 109595277
Neurotoxicity 27.28 10.25 243 987464 41964 109559628
Unevaluable event 27.09 10.25 369 987338 58858 109542734
COVID-19 26.90 10.25 1855 985852 243205 109358387
Arterial occlusive disease 26.88 10.25 231 987476 15077 109586515
Hepatojugular reflux 26.85 10.25 33 987674 702 109600890
Peripheral arterial occlusive disease 26.82 10.25 158 987549 9122 109592470
Malignant melanoma in situ 26.79 10.25 81 987626 3461 109598131
Eructation 26.75 10.25 216 987491 13841 109587751
Impaired work ability 26.71 10.25 133 987574 26286 109575306
Vaginal haemorrhage 26.65 10.25 124 987583 24950 109576642
Prescribed overdose 26.65 10.25 995 986712 86586 109515006
Reactive gastropathy 26.64 10.25 33 987674 708 109600884
Hepatotoxicity 26.54 10.25 402 987305 62998 109538594
Haematocrit decreased 26.50 10.25 776 986931 65341 109536251
Back injury 26.38 10.25 283 987424 47116 109554476
Dyskinesia 26.33 10.25 313 987394 51133 109550459
Schizophrenia 26.23 10.25 103 987604 21723 109579869
Adjustment disorder with depressed mood 25.97 10.25 543 987164 43340 109558252
Anosognosia 25.90 10.25 3 987704 4071 109597521
Hyperreflexia 25.72 10.25 28 987679 9457 109592135
Cognitive disorder 25.70 10.25 590 987117 86921 109514671
Cytomegalovirus chorioretinitis 25.57 10.25 16 987691 7112 109594480
Burns second degree 25.55 10.25 19 987688 7714 109593878
Pulmonary valve disease 25.53 10.25 23 987684 336 109601256
Tachypnoea 25.49 10.25 494 987213 38901 109562691
Oestradiol decreased 25.43 10.25 13 987694 67 109601525
Tension headache 25.41 10.25 29 987678 9589 109592003
Injection site mass 25.41 10.25 123 987584 24490 109577102
Intraocular pressure increased 25.41 10.25 36 987671 10840 109590752
Abnormal faeces 25.26 10.25 155 987552 9081 109592511
Hemiparesis 25.26 10.25 541 987166 43362 109558230
Surgery 25.24 10.25 241 987466 41042 109560550
Gastrointestinal vascular malformation haemorrhagic 25.03 10.25 37 987670 945 109600647
Diplopia 25.01 10.25 246 987461 41648 109559944
Blood pressure fluctuation 24.96 10.25 859 986848 73965 109527627
Electrocardiogram Q wave abnormal 24.95 10.25 32 987675 712 109600880
Underdose 24.92 10.25 408 987299 63146 109538446
Adrenal insufficiency 24.85 10.25 250 987457 42140 109559452
Hyperkalaemia 24.79 10.25 1466 986241 134330 109467262
Poor venous access 24.72 10.25 331 987376 24191 109577401
Faeces pale 24.67 10.25 76 987631 3281 109598311
Osteonecrosis of jaw 24.63 10.25 292 987415 47725 109553867
Tuberculosis 24.62 10.25 79 987628 17695 109583897
Mycotic allergy 24.61 10.25 112 987595 5842 109595750
Gastrointestinal bacterial overgrowth 24.60 10.25 30 987677 633 109600959
Intraventricular haemorrhage 24.58 10.25 106 987601 5401 109596191
Sopor 24.58 10.25 461 987246 36085 109565507
Tetanus 24.58 10.25 12 987695 55 109601537
Pregnancy with contraceptive device 24.53 10.25 3 987704 3904 109597688
Mania 24.45 10.25 99 987608 20697 109580895
Immune-mediated hepatic disorder 24.38 10.25 5 987702 4445 109597147
Pruritus genital 24.29 10.25 14 987693 6508 109595084
Bacteriuria 24.27 10.25 45 987662 1393 109600199
Leriche syndrome 24.26 10.25 16 987691 142 109601450
Total lung capacity abnormal 24.26 10.25 93 987614 4490 109597102
Haematoma muscle 24.17 10.25 86 987621 4004 109597588
Medication error 24.14 10.25 1162 986545 104204 109497388
Acute respiratory distress syndrome 24.13 10.25 332 987375 52866 109548726
Blindness 24.08 10.25 208 987499 36151 109565441
Complication of device insertion 24.06 10.25 26 987681 8812 109592780
Ventricular enlargement 24.06 10.25 31 987676 693 109600899
Duodenal ulcer perforation 24.04 10.25 1871 985836 175829 109425763
Disseminated tuberculosis 23.98 10.25 8 987699 5138 109596454
Hepatitis B reactivation 23.94 10.25 19 987688 7465 109594127
Pulmonary vasculitis 23.91 10.25 119 987588 6441 109595151
Cardiac failure congestive 23.90 10.25 1103 986604 149897 109451695
Fall 23.82 10.25 5903 981804 597579 109004013
Syringe issue 23.80 10.25 30 987677 9495 109592097
Deep vein thrombosis postoperative 23.80 10.25 696 987011 58595 109542997
Acute generalised exanthematous pustulosis 23.76 10.25 297 987410 21367 109580225
Epstein-Barr virus infection reactivation 23.64 10.25 4 987703 4080 109597512
Suspected suicide 23.63 10.25 64 987643 15135 109586457
Stomatitis 23.54 10.25 2758 984949 267484 109334108
Osteomyelitis 23.53 10.25 211 987496 36389 109565203
Lymphoproliferative disorder 23.50 10.25 18 987689 7200 109594392
Oesophageal candidiasis 23.47 10.25 180 987527 11354 109590238
Degenerative mitral valve disease 23.46 10.25 21 987686 304 109601288
Injection site discolouration 23.46 10.25 28 987679 9075 109592517
Gingival hypertrophy 23.45 10.25 5 987702 4326 109597266
Gastric xanthoma 23.42 10.25 8 987699 10 109601582
Solar urticaria 23.38 10.25 14 987693 103 109601489
Cystitis haemorrhagic 23.34 10.25 46 987661 12163 109589429
Osteochondrosis 23.32 10.25 62 987645 2459 109599133
Demyelination 23.25 10.25 30 987677 9399 109592193
Polycystic ovaries 23.16 10.25 7 987700 4789 109596803
Tongue disorder 23.15 10.25 59 987648 14239 109587353
Dysphagia 23.10 10.25 1631 986076 151969 109449623
Musculoskeletal disorder 22.97 10.25 114 987593 22550 109579042
Accidental death 22.97 10.25 8 987699 5001 109596591
Chest pain 22.93 10.25 3761 983946 372614 109228978
Alcohol interaction 22.80 10.25 3 987704 3691 109597901
Arrhythmia 22.77 10.25 797 986910 68778 109532814
Renal failure 22.72 10.25 2334 985373 224240 109377352
Product administered to patient of inappropriate age 22.60 10.25 23 987684 8013 109593579
Haemophagocytic lymphohistiocytosis 22.52 10.25 177 987530 31382 109570210
Abortion induced 22.50 10.25 23 987684 7996 109593596
Toxic skin eruption 22.45 10.25 358 987349 27157 109574435
Gastroenteritis clostridial 22.44 10.25 37 987670 1041 109600551
Anosmia 22.15 10.25 49 987658 12423 109589169
Respiratory depression 22.13 10.25 181 987526 31820 109569772
Right ventricular hypertrophy 22.07 10.25 48 987659 1671 109599921
Nasal obstruction 22.03 10.25 73 987634 3277 109598315
Stenosis 22.02 10.25 73 987634 3278 109598314
Local anaesthetic systemic toxicity 21.92 10.25 11 987696 5526 109596066
Sarcoidosis 21.87 10.25 50 987657 12529 109589063
Glaucoma 21.84 10.25 115 987592 22402 109579190
Cardiorenal syndrome 21.77 10.25 51 987656 1867 109599725
Transfusion 21.76 10.25 334 987373 25138 109576454
Parkinsonism 21.69 10.25 113 987594 22074 109579518
Autoimmune colitis 21.68 10.25 52 987655 1933 109599659
Therapeutic reaction time decreased 21.59 10.25 99 987608 5180 109596412
Nocardiosis 21.54 10.25 21 987686 7465 109594127
Aspergillus infection 21.54 10.25 137 987570 25479 109576113
Colorectal cancer 21.46 10.25 30 987677 9084 109592508
Polyomavirus-associated nephropathy 21.37 10.25 25 987682 8176 109593416
Therapeutic drug monitoring analysis incorrectly performed 21.36 10.25 29 987678 683 109600909
Systolic dysfunction 21.28 10.25 87 987620 4328 109597264
Adverse drug reaction 21.23 10.25 750 986957 104809 109496783
Vascular purpura 21.19 10.25 78 987629 3693 109597899
Heavy menstrual bleeding 21.12 10.25 75 987632 16290 109585302
Carotid artery thrombosis 21.08 10.25 153 987554 9485 109592107
Folate deficiency 21.03 10.25 87 987620 4351 109597241
Tongue oedema 20.99 10.25 136 987571 8120 109593472
Dysphoria 20.97 10.25 16 987691 6412 109595180
Condition aggravated 20.90 10.25 6048 981659 728788 108872804
Pulmonary sepsis 20.86 10.25 98 987609 5180 109596412
Skin disorder 20.86 10.25 264 987443 42649 109558943
Retroperitoneal haematoma 20.80 10.25 109 987598 6022 109595570
Unresponsive to stimuli 20.78 10.25 423 987284 63367 109538225
Rhinitis perennial 20.72 10.25 17 987690 217 109601375
Epileptic encephalopathy 20.71 10.25 28 987679 657 109600935
Product use issue 20.67 10.25 2452 985255 309243 109292349
Victim of child abuse 20.57 10.25 38 987669 1173 109600419
Hypovolaemic shock 20.56 10.25 210 987497 14373 109587219
Bone marrow failure 20.55 10.25 378 987329 57470 109544122
Incorrect dose administered 20.47 10.25 738 986969 102903 109498689
Generalised tonic-clonic seizure 20.47 10.25 354 987353 54326 109547266
X-ray abnormal 20.44 10.25 465 987242 37652 109563940
Pancreatitis acute 20.37 10.25 693 987014 59581 109542011
Sleep disorder therapy 20.32 10.25 22 987685 7449 109594143
Lung disorder 20.30 10.25 1870 985837 178177 109423415
Frequent bowel movements 20.28 10.25 805 986902 70585 109531007
Herpes zoster 20.23 10.25 777 986930 107602 109493990
Complication of device removal 20.14 10.25 8 987699 4612 109596980
Respiratory tract haemorrhage 20.14 10.25 51 987656 1963 109599629
Insomnia 20.10 10.25 2868 984839 357722 109243870
Swollen joint count increased 20.10 10.25 927 986780 82734 109518858
Microvillous inclusion disease 20.08 10.25 18 987689 261 109601331
Obstruction 20.02 10.25 103 987604 5649 109595943
Pancytopenia 19.99 10.25 2152 985555 207461 109394131
Hyperparathyroidism secondary 19.98 10.25 70 987637 3234 109598358
Cytomegalovirus test positive 19.94 10.25 20 987687 7016 109594576
Antineutrophil cytoplasmic antibody positive 19.88 10.25 94 987613 4982 109596610
Device dislocation 19.85 10.25 184 987523 31520 109570072
Hepatic steatosis 19.81 10.25 574 987133 48257 109553335
Tetany 19.79 10.25 74 987633 3530 109598062
Dislocation of vertebra 19.73 10.25 521 987186 43200 109558392
Blood pressure measurement 19.70 10.25 24 987683 506 109601086
Cytopenia 19.63 10.25 173 987534 29943 109571649
Occult blood 19.61 10.25 48 987659 1808 109599784
Strongyloidiasis 19.60 10.25 10 987697 4976 109596616
Nephrogenic anaemia 19.59 10.25 87 987620 4490 109597102
Chronic sinusitis 19.58 10.25 324 987383 24760 109576832
Restlessness 19.56 10.25 649 987058 55610 109545982
Pericardial disease 19.53 10.25 28 987679 695 109600897
Bronchial wall thickening 19.44 10.25 68 987639 3139 109598453
Granulocytopenia 19.42 10.25 54 987653 12661 109588931
Neutropenia 19.36 10.25 2993 984714 371627 109229965
Fear of injection 19.36 10.25 31 987676 8880 109592712
Bradycardia 19.35 10.25 1627 986080 153890 109447702
Intermenstrual bleeding 19.33 10.25 20 987687 6914 109594678
Epidural lipomatosis 19.29 10.25 51 987656 2016 109599576
Type I hypersensitivity 19.23 10.25 110 987597 6283 109595309
Lipase increased 19.22 10.25 253 987454 18419 109583173
Asthma-chronic obstructive pulmonary disease overlap syndrome 19.20 10.25 17 987690 6327 109595265
Thrombosis prophylaxis 19.19 10.25 10 987697 54 109601538
Child abuse 19.17 10.25 31 987676 858 109600734
Device deployment issue 19.15 10.25 7 987700 4246 109597346
Occupational dermatitis 19.15 10.25 14 987693 149 109601443
Plasma cell myeloma 19.14 10.25 715 986992 62221 109539371
Synovial fluid analysis 19.06 10.25 60 987647 2621 109598971
Metastases to lung 19.06 10.25 124 987583 22939 109578653
Helicobacter gastritis 19.02 10.25 59 987648 2557 109599035
Blood pressure diastolic decreased 19.00 10.25 437 987270 35448 109566144
Symmetrical drug-related intertriginous and flexural exanthema 18.93 10.25 48 987659 1849 109599743
Oesophageal ulcer haemorrhage 18.92 10.25 32 987675 920 109600672
Disability assessment scale score increased 18.91 10.25 82 987625 4188 109597404
Dysplastic naevus 18.87 10.25 30 987677 818 109600774
Neurologic neglect syndrome 18.86 10.25 145 987562 9153 109592439
Neoplasm progression 18.82 10.25 436 987271 64159 109537433
Tearfulness 18.79 10.25 23 987684 7372 109594220
Rib deformity 18.78 10.25 16 987691 216 109601376
Progressive multifocal leukoencephalopathy 18.73 10.25 138 987569 24818 109576774
Serum ferritin abnormal 18.68 10.25 22 987685 447 109601145
Pneumocystis jirovecii pneumonia 18.57 10.25 269 987438 42466 109559126
Disorientation 18.50 10.25 790 986917 69881 109531711
Cholestatic liver injury 18.45 10.25 121 987586 7255 109594337
Spleen ischaemia 18.35 10.25 10 987697 60 109601532
Gangrene 18.34 10.25 225 987482 16116 109585476
Amenorrhoea 18.33 10.25 34 987673 9197 109592395
Human herpesvirus 6 infection 18.32 10.25 19 987688 6562 109595030
Spinal pain 18.29 10.25 249 987458 18266 109583326
Hyperprolactinaemia 18.29 10.25 19 987688 6556 109595036
Endophthalmitis 18.24 10.25 28 987679 8159 109593433
Anastomotic infection 18.20 10.25 13 987694 133 109601459
Body mass index abnormal 18.18 10.25 31 987676 897 109600695
Intestinal intraepithelial lymphocytes increased 18.13 10.25 16 987691 227 109601365
Wound 18.13 10.25 2375 985332 232062 109369530
Femoral hernia incarcerated 18.09 10.25 41 987666 1468 109600124
Cryopyrin associated periodic syndrome 18.07 10.25 25 987682 600 109600992
Retinal haemorrhage 17.99 10.25 36 987671 9465 109592127
Virologic failure 17.92 10.25 11 987696 4941 109596651
Spontaneous haematoma 17.91 10.25 48 987659 1913 109599679
Physical examination abnormal 17.89 10.25 23 987684 513 109601079
Urinary tract infection enterococcal 17.88 10.25 73 987634 3629 109597963
Toxic epidermal necrolysis 17.87 10.25 647 987060 56080 109545512
Device breakage 17.84 10.25 63 987644 13706 109587886
Graft versus host disease in gastrointestinal tract 17.84 10.25 33 987674 8935 109592657
Electrocardiogram abnormal 17.82 10.25 250 987457 18459 109583133
Colitis erosive 17.78 10.25 17 987690 269 109601323
Bezoar 17.70 10.25 7 987700 4047 109597545
Mean cell haemoglobin concentration 17.66 10.25 9 987698 46 109601546
Procalcitonin abnormal 17.66 10.25 20 987687 389 109601203
Circulatory collapse 17.62 10.25 506 987201 42487 109559105
Ventricular arrhythmia 17.60 10.25 152 987555 9935 109591657
Sleep disorder due to a general medical condition 17.57 10.25 599 987108 51513 109550079
Nasopharyngitis 17.56 10.25 3879 983828 390482 109211110
Incorrect dose administered by device 17.51 10.25 21 987686 6793 109594799
Enteritis 17.46 10.25 254 987453 18902 109582690
Vertigo 17.44 10.25 946 986761 85924 109515668
SARS-CoV-2 antibody test positive 17.42 10.25 20 987687 395 109601197
Dysentery 17.28 10.25 38 987669 1333 109600259
Vitamin B12 deficiency 17.27 10.25 151 987556 9904 109591688
Cardiac aneurysm 17.25 10.25 44 987663 1701 109599891
Areflexia 17.25 10.25 21 987686 6748 109594844
Delirium 17.18 10.25 1415 986292 133610 109467982
Viral mutation identified 17.16 10.25 9 987698 4410 109597182
Drug therapy 17.16 10.25 24 987683 7267 109594325
Hypotension 17.16 10.25 5084 982623 518765 109082827
Myocardial infarction 17.14 10.25 1479 986228 190604 109410988
Lupus vulgaris 17.14 10.25 410 987297 33473 109568119
Analgesic therapy 17.12 10.25 24 987683 7260 109594332
Postoperative renal failure 17.11 10.25 14 987693 178 109601414
Myasthenia gravis 17.10 10.25 117 987590 21394 109580198
Retinal detachment 17.06 10.25 47 987660 11053 109590539
Red blood cell count decreased 17.05 10.25 736 986971 65187 109536405
Rectal prolapse 16.99 10.25 56 987651 2507 109599085
Electroencephalogram abnormal 16.99 10.25 18 987689 6155 109595437
Injury associated with device 16.96 10.25 9 987698 4380 109597212
Mucous stools 16.93 10.25 112 987595 6735 109594857
Cerebral ischaemia 16.92 10.25 174 987533 11930 109589662
Gravitational oedema 16.87 10.25 46 987661 1852 109599740
Stupor 16.81 10.25 30 987677 8235 109593357
Anal haemorrhage 16.77 10.25 88 987619 4864 109596728
Lichenoid keratosis 16.76 10.25 105 987602 6197 109595395
Skin burning sensation 16.71 10.25 120 987587 21705 109579887
Faecal calprotectin increased 16.67 10.25 110 987597 6609 109594983
Fatigue 16.62 10.25 11463 976244 1204495 108397097
Salpingo-oophorectomy unilateral 16.60 10.25 28 987679 803 109600789
Anaemia of malignant disease 16.60 10.25 31 987676 965 109600627
Gastric polyps 16.59 10.25 95 987612 5428 109596164
Intracranial mass 16.57 10.25 53 987654 2335 109599257
Alanine aminotransferase increased 16.55 10.25 1414 986293 182359 109419233
Gastrooesophageal reflux disease 16.51 10.25 1843 985864 178133 109423459
Intestinal obstruction 16.50 10.25 606 987101 52621 109548971
Alopecia 16.49 10.25 2936 984771 361817 109239775
Diabetic ketoacidosis 16.49 10.25 270 987437 41788 109559804
Cystostomy 16.43 10.25 10 987697 76 109601516
Vocal cord dysfunction 16.37 10.25 30 987677 920 109600672
Psychological trauma 16.35 10.25 42 987665 1631 109599961
Application site pain 16.32 10.25 15 987692 5484 109596108
Metastatic malignant melanoma 16.29 10.25 67 987640 3342 109598250
Creatinine renal clearance increased 16.26 10.25 6 987701 3619 109597973
Organic brain syndrome 16.25 10.25 23 987684 564 109601028
Blood glucose increased 16.22 10.25 993 986714 131503 109470089
Biliary cirrhosis 16.22 10.25 15 987692 227 109601365
Chronic gastritis 16.21 10.25 93 987614 5318 109596274
Orthostatic hypotension 16.14 10.25 459 987248 65790 109535802
Lumbar vertebral fracture 16.14 10.25 138 987569 8993 109592599
Pericarditis 16.10 10.25 2213 985494 216901 109384691
Paralysis 16.08 10.25 78 987629 15522 109586070
Vomiting 16.07 10.25 8648 979059 902027 108699565
Decreased appetite 16.07 10.25 4624 983083 471222 109130370
Tendonitis 16.06 10.25 152 987555 25931 109575661
Acute graft versus host disease in intestine 16.02 10.25 16 987691 5623 109595969
Bone disorder 16.00 10.25 117 987590 21075 109580517
Inferior vena cava dilatation 15.99 10.25 30 987677 937 109600655
Brain oedema 15.99 10.25 189 987518 30909 109570683
Mental status changes 15.97 10.25 538 987169 75584 109526008
Gastric cancer 15.90 10.25 48 987659 10960 109590632
Abdominal wall haemorrhage 15.88 10.25 26 987681 727 109600865
Cardiac murmur 15.82 10.25 142 987565 24486 109577106
Rash papular 15.79 10.25 164 987543 27475 109574117
Iridocyclitis 15.76 10.25 15 987692 5393 109596199
Mean cell haemoglobin decreased 15.76 10.25 114 987593 7060 109594532
Muscle twitching 15.76 10.25 181 987526 29754 109571838
Cystoid macular oedema 15.65 10.25 3 987704 2797 109598795
Nasal oedema 15.62 10.25 23 987684 6816 109594776
Peripheral artery bypass 15.60 10.25 11 987696 110 109601482
Vascular stent stenosis 15.58 10.25 39 987668 1490 109600102
Premature labour 15.51 10.25 37 987670 9135 109592457
Chest injury 15.51 10.25 66 987641 3343 109598249
Upper respiratory tract irritation 15.50 10.25 15 987692 241 109601351
Eye swelling 15.44 10.25 205 987502 32843 109568749
Device dependence 15.39 10.25 9 987698 63 109601529
Fungaemia 15.39 10.25 19 987688 6067 109595525
Meralgia paraesthetica 15.37 10.25 23 987684 594 109600998
Neuritis 15.36 10.25 116 987591 7283 109594309
Sensitisation 15.33 10.25 9 987698 4142 109597450
Tenosynovitis 15.33 10.25 84 987623 16199 109585393
Flank pain 15.29 10.25 291 987416 22839 109578753
Ventriculo-peritoneal shunt 15.28 10.25 9 987698 64 109601528
Wheezing 15.26 10.25 2548 985159 252682 109348910
Abdominal wall wound 15.23 10.25 10 987697 88 109601504
Palmar-plantar erythrodysaesthesia syndrome 15.23 10.25 266 987441 40759 109560833
Adenocarcinoma gastric 15.22 10.25 47 987660 2032 109599560
Chronic obstructive pulmonary disease 15.20 10.25 1152 986555 108006 109493586
Mood altered 15.19 10.25 120 987587 21255 109580337
Intestinal haemorrhage 15.18 10.25 115 987592 7226 109594366
Lymphatic fistula 15.10 10.25 38 987669 1457 109600135
Umbilical hernia 15.09 10.25 111 987596 6911 109594681
Intestinal villi atrophy 15.08 10.25 22 987685 555 109601037
Incorrect product administration duration 15.08 10.25 114 987593 20384 109581208
Granuloma skin 15.04 10.25 51 987656 11232 109590360
Pulmonary function test abnormal 15.02 10.25 86 987621 4914 109596678
Second primary malignancy 15.00 10.25 97 987610 17971 109583621
Oesophagitis 14.99 10.25 349 987358 28366 109573226
Urine alcohol test positive 14.95 10.25 8 987699 46 109601546
Periarthritis calcarea 14.87 10.25 10 987697 92 109601500
Thinking abnormal 14.86 10.25 77 987630 15063 109586529
Accidental exposure to product by child 14.85 10.25 5 987702 3193 109598399
Histoplasmosis 14.83 10.25 4 987703 2949 109598643
Anger 14.80 10.25 104 987603 18903 109582689
Chronic kidney disease-mineral and bone disorder 14.79 10.25 23 987684 615 109600977
Disturbance in social behaviour 14.77 10.25 14 987693 5044 109596548
Mixed liver injury 14.74 10.25 169 987538 11910 109589682
Renal cancer 14.73 10.25 63 987644 12971 109588621
Mobility decreased 14.70 10.25 1876 985831 235546 109366046
Oculogyric crisis 14.60 10.25 8 987699 3824 109597768
Therapy interrupted 14.60 10.25 336 987371 49486 109552106
Intestinal anastomosis complication 14.57 10.25 18 987689 385 109601207
Blood iron decreased 14.56 10.25 247 987460 18967 109582625
Pneumonia bacterial 14.53 10.25 157 987550 26104 109575488
Dry eye 14.52 10.25 383 987324 55410 109546182
Anaemia folate deficiency 14.51 10.25 24 987683 677 109600915
Aortic valve incompetence 14.48 10.25 156 987551 10825 109590767
Aphasia 14.45 10.25 655 987052 58342 109543250
Apparent death 14.44 10.25 4 987703 2898 109598694
Bile duct stone 14.43 10.25 101 987606 6188 109595404
Acquired haemophilia 14.43 10.25 54 987653 2577 109599015
Arteriosclerotic gangrene 14.41 10.25 9 987698 72 109601520
Headache 14.40 10.25 7411 980296 874966 108726626
Pneumothorax 14.34 10.25 225 987482 35060 109566532
Epstein-Barr viraemia 14.33 10.25 7 987700 3572 109598020
Carotid artery occlusion 14.33 10.25 41 987666 9524 109592068
Tenosynovitis stenosans 14.32 10.25 67 987640 3536 109598056
SJS-TEN overlap 14.31 10.25 43 987664 1831 109599761
Reversible airways obstruction 14.30 10.25 52 987655 2447 109599145
Renal tubular necrosis 14.29 10.25 365 987342 30110 109571482
Hepatic enzyme 14.27 10.25 15 987692 5148 109596444
Lower limb fracture 14.24 10.25 816 986891 74532 109527060
Maternal exposure during delivery 14.24 10.25 7 987700 3558 109598034
Urinary tract obstruction 14.23 10.25 87 987620 5090 109596502
Suture rupture 14.21 10.25 24 987683 689 109600903
Internal haemorrhage 14.19 10.25 145 987562 9926 109591666
Ischaemic nephropathy 14.19 10.25 10 987697 100 109601492
Bronchial secretion retention 14.18 10.25 85 987622 4939 109596653
Hypochloraemia 14.17 10.25 67 987640 3551 109598041
Benign gastrointestinal neoplasm 14.17 10.25 11 987696 129 109601463
Hyperlipasaemia 14.16 10.25 37 987670 1452 109600140
Injection site induration 14.14 10.25 53 987654 11330 109590262
Activated partial thromboplastin time shortened 14.13 10.25 30 987677 1027 109600565
Hyperphosphataemia 14.09 10.25 87 987620 16294 109585298
Staphylococcal infection 14.05 10.25 497 987210 69447 109532145
Splenic thrombosis 14.03 10.25 11 987696 131 109601461
Cholecystitis chronic 13.97 10.25 138 987569 9362 109592230
Parkinsonism hyperpyrexia syndrome 13.94 10.25 22 987685 596 109600996
JC virus infection 13.92 10.25 16 987691 5274 109596318
Acute megakaryocytic leukaemia 13.92 10.25 8 987699 54 109601538
N-terminal prohormone brain natriuretic peptide increased 13.87 10.25 98 987609 6023 109595569
Crepitations 13.86 10.25 153 987554 10682 109590910
Cold sweat 13.83 10.25 275 987432 21756 109579836
Therapeutic response unexpected 13.82 10.25 141 987566 23702 109577890
Confabulation 13.82 10.25 20 987687 501 109601091
Forced expiratory volume decreased 13.76 10.25 179 987528 12997 109588595
Dilatation intrahepatic duct acquired 13.75 10.25 26 987681 817 109600775
Product complaint 13.75 10.25 71 987636 13901 109587691
Metabolic surgery 13.74 10.25 36 987671 1415 109600177
Tic 13.74 10.25 7 987700 3486 109598106
Granulocytes maturation arrest 13.68 10.25 8 987699 56 109601536
Application site erythema 13.68 10.25 18 987689 5592 109596000
Metabolic disorder 13.68 10.25 48 987659 10462 109591130
Aspartate aminotransferase increased 13.61 10.25 1236 986471 158700 109442892
Cardiovascular disorder 13.59 10.25 282 987425 22478 109579114
Colitis microscopic 13.59 10.25 181 987526 13213 109588379
Respiratory symptom 13.56 10.25 198 987509 14747 109586845
Delusion 13.55 10.25 141 987566 23614 109577978
Pneumonitis chemical 13.50 10.25 23 987684 665 109600927
Product administered at inappropriate site 13.46 10.25 17 987690 5376 109596216
Enterovirus infection 13.45 10.25 4 987703 2766 109598826
Dizziness 13.42 10.25 6648 981059 691545 108910047
Product quality issue 13.39 10.25 559 987148 76740 109524852
Substance use 13.35 10.25 3 987704 2503 109599089
Feeling jittery 13.34 10.25 195 987512 14527 109587065
Cryptitis 13.33 10.25 17 987690 376 109601216
Aphthous ulcer 13.32 10.25 264 987443 20872 109580720
Faeces soft 13.31 10.25 156 987551 11054 109590538
Gene mutation 13.29 10.25 7 987700 3422 109598170
Bacteraemia 13.24 10.25 283 987424 42107 109559485
Product dose omission in error 13.24 10.25 140 987567 23372 109578220
Injection site scab 13.22 10.25 22 987685 624 109600968
Faeces discoloured 13.21 10.25 397 987310 33551 109568041
Pneumatosis intestinalis 13.19 10.25 36 987671 8493 109593099
Intensive care 13.19 10.25 49 987658 2330 109599262
Ocular icterus 13.19 10.25 96 987611 5957 109595635
Vena cava injury 13.18 10.25 16 987691 336 109601256
Blood parathyroid hormone decreased 13.17 10.25 66 987641 13023 109588569
Walking aid user 13.16 10.25 305 987402 24770 109576822
Pseudomembranous colitis 13.15 10.25 100 987607 6291 109595301
Peripheral venous disease 13.13 10.25 896 986811 83221 109518371
Petit mal epilepsy 13.12 10.25 30 987677 7517 109594075
Hyperparathyroidism 13.11 10.25 68 987639 3742 109597850
Dental caries 13.09 10.25 64 987643 12709 109588883
Metamyelocyte count increased 13.07 10.25 23 987684 683 109600909
Anaesthetic complication 13.07 10.25 8 987699 3598 109597994
Rebound effect 13.06 10.25 78 987629 14728 109586864
Ankylosing spondylitis 13.06 10.25 204 987503 15408 109586184
Carcinoid tumour of the stomach 13.06 10.25 12 987695 180 109601412
Contraindicated product administered 13.06 10.25 2462 985245 245805 109355787
Cholecystitis 13.03 10.25 313 987394 25569 109576023
Cardiovascular insufficiency 12.96 10.25 61 987646 3227 109598365
Venoocclusive disease 12.96 10.25 23 987684 6327 109595265
Venoocclusive liver disease 12.95 10.25 81 987626 15126 109586466
Infective pulmonary exacerbation of cystic fibrosis 12.94 10.25 78 987629 14693 109586899
Steatorrhoea 12.91 10.25 29 987678 1032 109600560
Congenital coronary artery malformation 12.90 10.25 10 987697 117 109601475
Cardiomyopathy 12.89 10.25 216 987491 33309 109568283
Disease risk factor 12.87 10.25 14 987693 260 109601332
Chondrocalcinosis 12.83 10.25 43 987664 1942 109599650
Helicobacter test false negative 12.81 10.25 8 987699 64 109601528
Neurosis 12.78 10.25 21 987686 589 109601003
Alveolar lung disease 12.77 10.25 23 987684 696 109600896
Spinal compression fracture 12.73 10.25 104 987603 18288 109583304
Ileocolostomy 12.71 10.25 7 987700 43 109601549
Abdominal wall cyst 12.71 10.25 7 987700 43 109601549
Biliary dyskinesia 12.71 10.25 49 987658 2372 109599220
Haemorrhagic erosive gastritis 12.61 10.25 24 987683 758 109600834
Eosinophils urine present 12.61 10.25 8 987699 66 109601526
Behaviour disorder 12.59 10.25 44 987663 9603 109591989
Fear of disease 12.59 10.25 34 987673 1361 109600231
Ototoxicity 12.58 10.25 11 987696 4120 109597472
Endotracheal intubation 12.57 10.25 96 987611 6048 109595544
Erythema multiforme 12.54 10.25 124 987583 20973 109580619
Kounis syndrome 12.51 10.25 21 987686 5904 109595688
Colitis 12.49 10.25 1069 986638 101254 109500338
Secondary immunodeficiency 12.46 10.25 14 987693 4662 109596930
Alveolitis 12.46 10.25 75 987632 4364 109597228
Inflammation 12.44 10.25 1523 986184 191715 109409877
Periodontitis 12.40 10.25 17 987690 5191 109596401
Tumour pain 12.40 10.25 56 987651 2911 109598681
Mouth ulceration 12.38 10.25 331 987376 47807 109553785
Mucosal ulceration 12.38 10.25 3 987704 2376 109599216
Intentional dose omission 12.37 10.25 117 987590 19963 109581629
Arterial haemorrhage 12.34 10.25 67 987640 3752 109597840
Blood osmolarity decreased 12.33 10.25 35 987672 1443 109600149
Cardiac dysfunction 12.29 10.25 23 987684 6200 109595392
Paranoia 12.28 10.25 134 987573 22240 109579352
Vaccination site reaction 12.27 10.25 13 987694 234 109601358
Panniculitis 12.26 10.25 85 987622 15497 109586095
Myalgia 12.24 10.25 1770 985937 220611 109380981
Aortic dilatation 12.24 10.25 46 987661 2200 109599392
Dermatitis acneiform 12.22 10.25 65 987642 12630 109588962
Diarrhoea haemorrhagic 12.20 10.25 202 987505 15437 109586155
Haemodynamic instability 12.20 10.25 138 987569 22750 109578842
Eye disorder 12.20 10.25 183 987524 28723 109572869
Cryptococcosis 12.20 10.25 14 987693 4617 109596975
Occupational exposure to air contaminants 12.19 10.25 11 987696 161 109601431
Amylase decreased 12.18 10.25 13 987694 236 109601356
Lipoedema 12.18 10.25 13 987694 236 109601356
Atheroembolism 12.17 10.25 16 987691 365 109601227
Priapism 12.17 10.25 21 987686 5840 109595752
Coronary artery disease 12.16 10.25 769 986938 70921 109530671
Inspiratory capacity decreased 12.15 10.25 4 987703 2591 109599001
Xyphoid retraction 12.14 10.25 11 987696 162 109601430
Pancreatic duct stenosis 12.09 10.25 13 987694 238 109601354
Faeces hard 12.08 10.25 72 987635 4174 109597418
Mitochondrial toxicity 12.04 10.25 7 987700 3238 109598354
Wrong patient 12.02 10.25 35 987672 1464 109600128
Faecal vomiting 12.02 10.25 36 987671 1530 109600062
Thrombophlebitis 12.01 10.25 113 987594 7566 109594026
Gastrointestinal ulcer 11.97 10.25 72 987635 4188 109597404
Dermatomyositis 11.95 10.25 13 987694 4393 109597199
Coronavirus test positive 11.94 10.25 32 987675 1275 109600317
Optic neuritis 11.92 10.25 55 987652 11092 109590500
Oesophageal variceal ligation 11.92 10.25 11 987696 166 109601426
Perihepatic abscess 11.92 10.25 11 987696 166 109601426
Erectile dysfunction 11.92 10.25 107 987600 18449 109583143
Drooling 11.91 10.25 29 987678 7110 109594482
Gastroenteritis salmonella 11.90 10.25 33 987674 1342 109600250
Meningitis cryptococcal 11.90 10.25 15 987692 4747 109596845
Eosinophilic oesophagitis 11.87 10.25 32 987675 1280 109600312
Chest X-ray abnormal 11.86 10.25 122 987585 8365 109593227
Cerebral haematoma 11.86 10.25 135 987572 9497 109592095
Epigastric discomfort 11.86 10.25 128 987579 8887 109592705
Toothache 11.85 10.25 144 987563 23431 109578161
Neurosensory hypoacusis 11.84 10.25 13 987694 244 109601348
Renal cyst haemorrhage 11.84 10.25 23 987684 738 109600854
Probiotic therapy 11.81 10.25 11 987696 168 109601424
Urine output decreased 11.74 10.25 117 987590 19759 109581833
Tardive dyskinesia 11.74 10.25 72 987635 13507 109588085
Blood immunoglobulin G abnormal 11.74 10.25 10 987697 135 109601457
Brain abscess 11.72 10.25 27 987680 6747 109594845
Normal newborn 11.68 10.25 132 987575 21764 109579828
Central nervous system lesion 11.68 10.25 86 987621 15467 109586125
Prerenal failure 11.67 10.25 74 987633 4385 109597207
Acute myocardial infarction 11.64 10.25 884 986823 82893 109518699
Emotional distress 11.63 10.25 308 987399 44539 109557053
Subcutaneous drug absorption impaired 11.63 10.25 112 987595 7547 109594045
Obsessive-compulsive disorder 11.63 10.25 30 987677 7211 109594381
Waist circumference increased 11.63 10.25 39 987668 1762 109599830
Granulocyte count decreased 11.61 10.25 11 987696 3963 109597629
Diffuse large B-cell lymphoma refractory 11.60 10.25 4 987703 2517 109599075
Drug abuser 11.58 10.25 19 987688 5390 109596202
Renal impairment 11.57 10.25 1884 985823 186561 109415031
Glomerular filtration rate abnormal 11.52 10.25 47 987660 2336 109599256
SARS-CoV-2 sepsis 11.51 10.25 13 987694 252 109601340
Hepatocellular carcinoma 11.51 10.25 137 987570 9743 109591849
Distributive shock 11.50 10.25 22 987685 5882 109595710
Device failure 11.47 10.25 30 987677 7177 109594415
Thoracic vertebral fracture 11.46 10.25 100 987607 6555 109595037
Bursitis 11.45 10.25 1327 986380 128591 109473001
Miller Fisher syndrome 11.42 10.25 15 987692 342 109601250
Seroma 11.41 10.25 59 987648 3242 109598350
Pneumonia viral 11.41 10.25 151 987556 11006 109590586
Endoscopy upper gastrointestinal tract 11.38 10.25 10 987697 141 109601451
Bladder diverticulum 11.38 10.25 10 987697 141 109601451
Limb deformity 11.38 10.25 10 987697 3736 109597856
Sensory level abnormal 11.36 10.25 11 987696 177 109601415
Vascular anastomotic haemorrhage 11.35 10.25 14 987693 299 109601293
Biliary dilatation 11.32 10.25 63 987644 3562 109598030
Leukoencephalopathy 11.30 10.25 43 987664 9152 109592440
Arterial stenosis 11.30 10.25 36 987671 1583 109600009
Forced vital capacity decreased 11.28 10.25 41 987666 1929 109599663
Arteriovenous fistula 11.27 10.25 34 987673 1451 109600141
Scleritis 11.26 10.25 85 987622 5335 109596257
Blood prolactin increased 11.21 10.25 15 987692 4627 109596965
Vascular dissection 11.18 10.25 3 987704 0 109601592
Blood alcohol abnormal 11.18 10.25 3 987704 0 109601592
Pancreatic carcinoma stage IV 11.16 10.25 3 987704 2217 109599375
Maternal exposure timing unspecified 11.16 10.25 256 987451 20757 109580835
Hyperthermia malignant 11.15 10.25 11 987696 3889 109597703
Gastrointestinal procedural complication 11.11 10.25 17 987690 448 109601144
Glomerulonephropathy 11.09 10.25 15 987692 352 109601240
Immature granulocyte count increased 11.08 10.25 24 987683 833 109600759
Inflammation of wound 11.06 10.25 11 987696 183 109601409
Left ventricular hypertrophy 11.06 10.25 173 987534 13071 109588521
Mean cell volume decreased 11.06 10.25 88 987619 5614 109595978
Anti factor V antibody 11.03 10.25 14 987693 308 109601284
Cell death 11.03 10.25 89 987618 5702 109595890
Cardiovascular somatic symptom disorder 11.01 10.25 6 987701 36 109601556
Hypertonic bladder 11.00 10.25 19 987688 5283 109596309
Pseudarthrosis 11.00 10.25 14 987693 309 109601283
Pulmonary interstitial emphysema syndrome 10.99 10.25 19 987688 556 109601036
Lip oedema 10.98 10.25 110 987597 7490 109594102
Diffuse large B-cell lymphoma 10.96 10.25 90 987617 15808 109585784
Hyperleukocytosis 10.89 10.25 60 987647 3379 109598213
Muscle rigidity 10.89 10.25 150 987557 23881 109577711
Reversible cerebral vasoconstriction syndrome 10.88 10.25 16 987691 4745 109596847
Administration site discomfort 10.87 10.25 11 987696 187 109601405
Focal dyscognitive seizures 10.84 10.25 11 987696 3838 109597754
Metastases to bone 10.83 10.25 206 987501 31166 109570426
Pancreatic enzyme abnormality 10.83 10.25 11 987696 188 109601404
Food aversion 10.83 10.25 36 987671 1619 109599973
Injection site irritation 10.82 10.25 17 987690 4907 109596685
Left ventricular enlargement 10.82 10.25 24 987683 847 109600745
Viral infection 10.81 10.25 377 987330 52762 109548830
Intervertebral disc protrusion 10.80 10.25 324 987383 27374 109574218
Wrong technique in device usage process 10.77 10.25 29 987678 6872 109594720
Lymphadenopathy 10.77 10.25 463 987244 63372 109538220
Bacterial test 10.75 10.25 29 987678 1160 109600432
Foetal growth restriction 10.73 10.25 7 987700 3043 109598549
Exposure via skin contact 10.70 10.25 71 987636 13076 109588516
Wound infection fungal 10.69 10.25 12 987695 231 109601361
Burning sensation 10.66 10.25 507 987200 68705 109532887
TP53 gene mutation 10.62 10.25 10 987697 155 109601437
Peripheral nerve paresis 10.62 10.25 6 987701 39 109601553
Rectal abscess 10.61 10.25 50 987657 2646 109598946
Hospitalisation 10.61 10.25 1112 986595 141381 109460211
Laryngeal stenosis 10.60 10.25 32 987675 1366 109600226
Atrial tachycardia 10.60 10.25 44 987663 9134 109592458
Lactescent serum 10.59 10.25 4 987703 8 109601584
Chronic actinic dermatitis 10.58 10.25 5 987702 21 109601571
Organising pneumonia 10.58 10.25 79 987628 14164 109587428
Depressive symptom 10.57 10.25 39 987668 8375 109593217
Atypical pneumonia 10.51 10.25 112 987595 7750 109593842
Application site pruritus 10.50 10.25 13 987694 4147 109597445
Stasis dermatitis 10.50 10.25 38 987669 1784 109599808
Rabies 10.50 10.25 6 987701 40 109601552
Butterfly rash 10.49 10.25 3 987704 2128 109599464
Granulomatosis with polyangiitis 10.46 10.25 60 987647 3430 109598162
Chronic allograft nephropathy 10.45 10.25 3 987704 2123 109599469
Device use issue 10.45 10.25 11 987696 3773 109597819
Wound infection pseudomonas 10.45 10.25 46 987661 2365 109599227
Sebaceous gland infection 10.42 10.25 10 987697 159 109601433
Myeloblast percentage decreased 10.38 10.25 6 987701 41 109601551
Actinic keratosis 10.38 10.25 102 987605 6911 109594681
Porphyria acute 10.35 10.25 230 987477 18550 109583042
Neuralgia 10.31 10.25 342 987365 48136 109553456
Maternal exposure before pregnancy 10.27 10.25 32 987675 7233 109594359
Pharyngeal dystonia 10.26 10.25 6 987701 42 109601550
Electrocardiogram QRS complex prolonged 10.26 10.25 71 987636 12950 109588642

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BC02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Proton pump inhibitors
ATC A02BD04 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
ATC A02BD11 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
FDA MoA N0000000147 Proton Pump Inhibitors
FDA EPC N0000175525 Proton Pump Inhibitor
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054328 Proton Pump Inhibitors
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35718 antifungal agent
CHEBI has role CHEBI:49200 EC 3.6.3.10 (<em>H</em><small><sup>+</small></sup>/<em>K</em><small><sup>+</small></sup>-exchanging ATPase) inhibitor
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:78298 environmental contaminant

Related Drugs by ATC class:

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A02BD Combinations for eradication of Helicobacter pylori 13 drugs
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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Erosive esophagitis indication 40719004
Zollinger-Ellison syndrome indication 53132006 DOID:0050782
Multiple endocrine adenomas indication 60549007
Gastroesophageal reflux disease indication 235595009 DOID:8534
Maintenance of Healing Erosive Esophagitis indication
Gastric Hypersecretory Conditions indication
Upper gastrointestinal hemorrhage off-label use 37372002
Duodenal ulcer disease off-label use 51868009 DOID:1724
Gastric ulcer off-label use 397825006 DOID:10808
Pathological Gastric Hypersecretory Condition off-label use
Duodenal Ulcer due to H. Pylori off-label use
Prevention of NSAID-Induced Gastric Ulcer off-label use
Osteoporosis contraindication 64859006 DOID:11476
Pernicious anemia contraindication 84027009 DOID:13381
Fracture of bone contraindication 125605004
Hypomagnesemia contraindication 190855004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.42 acidic
pKa2 3.58 Basic
pKa3 2.32 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 40MG BASE/VIAL PROTONIX IV WYETH PHARMS N020988 March 22, 2001 RX INJECTABLE INTRAVENOUS Aug. 12, 2027 NEW PATIENT POPULATION

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Potassium-transporting ATPase Transporter INHIBITOR CHEMBL CHEMBL
ATP-binding cassette sub-family G member 2 Transporter IC50 5.26 CHEMBL
Fatty acid synthase Enzyme Ki 5.39 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 5.82 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 5.55 CHEMBL
Multidrug and toxin extrusion protein 2 Transporter IC50 4.36 CHEMBL
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Enzyme IC50 4.20 CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter WOMBAT-PK
Indoleamine 2,3-dioxygenase 2 Enzyme IC50 4.90 CHEMBL
Potassium-transporting ATPase Enzyme IC50 6 SCIENTIFIC LITERATURE

External reference:

IDSource
4021208 VUID
N0000148654 NUI
D02593 KEGG_DRUG
164579-32-2 SECONDARY_CAS_RN
4021208 VANDF
4021209 VANDF
C0081876 UMLSCUI
CHEBI:7915 CHEBI
CHEMBL1502 ChEMBL_ID
CHEMBL3989559 ChEMBL_ID
DB00213 DRUGBANK_ID
D000077402 MESH_DESCRIPTOR_UI
4679 PUBCHEM_CID
7260 IUPHAR_LIGAND_ID
6548 INN_ID
D8TST4O562 UNII
236632 RXNORM
130104 MMSL
42003 MMSL
8654 MMSL
d04514 MMSL
006006 NDDF
006493 NDDF
009120 NDDF
116510001 SNOMEDCT_US
317317009 SNOMEDCT_US
395821003 SNOMEDCT_US
432408008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
ProtonixDelayed-Release HUMAN PRESCRIPTION DRUG LABEL 1 0008-0841 TABLET, DELAYED RELEASE 40 mg ORAL NDA 29 sections
ProtonixDelayed-Release HUMAN PRESCRIPTION DRUG LABEL 1 0008-0843 TABLET, DELAYED RELEASE 20 mg ORAL NDA 29 sections
ProtonixDelayed-Release HUMAN PRESCRIPTION DRUG LABEL 1 0008-0844 GRANULE, DELAYED RELEASE 40 mg ORAL NDA 29 sections
ProtonixI.V. HUMAN PRESCRIPTION DRUG LABEL 1 0008-0923 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 28 sections
ProtonixI.V. HUMAN PRESCRIPTION DRUG LABEL 1 0008-4001 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9284 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 40 mg INTRAVENOUS NDA 25 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9300 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 40 mg INTRAVENOUS NDA 25 sections
PANTOPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0338-9644 INJECTION, SOLUTION 40 mg INTRAVENOUS NDA 26 sections
PANTOPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0338-9646 INJECTION, SOLUTION 40 mg INTRAVENOUS NDA 26 sections
PANTOPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 0338-9648 INJECTION, SOLUTION 80 mg INTRAVENOUS NDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-6688 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-6689 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 27 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7629 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 27 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8113 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0781-3232 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS ANDA 28 sections
PANTOPRAZOLE SODIUMI.V. HUMAN PRESCRIPTION DRUG LABEL 1 0781-3480 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS ANDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0904-6474 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0904-6870 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0904-6870 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0904-7458 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0904-7458 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-096 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-429 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 26 sections
PANTOPRAZOLE SODIUMDELAYED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 16590-635 TABLET, DELAYED RELEASE 20 mg ORAL NDA 30 sections
PROTONIXDELAYED-RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 16590-939 TABLET, DELAYED RELEASE 20 mg ORAL NDA 30 sections
Protonix HUMAN PRESCRIPTION DRUG LABEL 1 21695-108 TABLET, DELAYED RELEASE 40 mg ORAL NDA 27 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-771 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 25021-751 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 40 mg INTRAVENOUS ANDA 28 sections
Pantoprazole sodium Human Prescription Drug Label 1 27241-256 FOR SUSPENSION 40 mg ORAL ANDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 31722-032 GRANULE, DELAYED RELEASE 40 mg ORAL ANDA 25 sections