Stem definition | Drug id | CAS RN |
---|---|---|
antiulcer, benzimidazole derivatives | 2054 | 102625-70-7 |
Dose | Unit | Route |
---|---|---|
40 | mg | O |
40 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.74 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 0.17 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.90 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 2, 2000 | FDA | WYETH PHARMS INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
General physical health deterioration | 749.67 | 9.84 | 2620 | 398597 | 144322 | 52803527 |
Chronic kidney disease | 566.57 | 9.84 | 1102 | 400115 | 42268 | 52905581 |
Completed suicide | 466.30 | 9.84 | 228 | 400989 | 137973 | 52809876 |
Toxicity to various agents | 409.90 | 9.84 | 636 | 400581 | 218962 | 52728887 |
Drug ineffective | 401.10 | 9.84 | 4077 | 397140 | 813168 | 52134681 |
Exposure during pregnancy | 325.63 | 9.84 | 276 | 400941 | 124584 | 52823265 |
Haematochezia | 284.67 | 9.84 | 831 | 400386 | 41527 | 52906322 |
Folliculitis | 271.25 | 9.84 | 680 | 400537 | 31029 | 52916820 |
Muscle injury | 260.58 | 9.84 | 644 | 400573 | 29122 | 52918727 |
Maternal exposure during pregnancy | 246.63 | 9.84 | 499 | 400718 | 155140 | 52792709 |
Irritable bowel syndrome | 218.58 | 9.84 | 774 | 400443 | 42858 | 52904991 |
Product prescribing error | 206.59 | 9.84 | 503 | 400714 | 22528 | 52925321 |
Acute kidney injury | 204.52 | 9.84 | 2856 | 398361 | 251012 | 52696837 |
Death | 197.61 | 9.84 | 1727 | 399490 | 355505 | 52592344 |
Anaemia | 177.84 | 9.84 | 2996 | 398221 | 273722 | 52674127 |
Rheumatoid arthritis | 171.46 | 9.84 | 1526 | 399691 | 313005 | 52634844 |
End stage renal disease | 170.35 | 9.84 | 221 | 400996 | 5950 | 52941899 |
Device expulsion | 168.70 | 9.84 | 15 | 401202 | 29798 | 52918051 |
Treatment failure | 162.64 | 9.84 | 463 | 400754 | 127940 | 52819909 |
Abdominal pain upper | 161.66 | 9.84 | 1937 | 399280 | 164354 | 52783495 |
Off label use | 160.97 | 9.84 | 2541 | 398676 | 469671 | 52478178 |
Sleep disorder due to general medical condition, insomnia type | 160.03 | 9.84 | 474 | 400743 | 23875 | 52923974 |
Lower respiratory tract infection | 159.26 | 9.84 | 1201 | 400016 | 89780 | 52858069 |
Abortion spontaneous | 155.56 | 9.84 | 78 | 401139 | 46557 | 52901292 |
Impaired healing | 154.88 | 9.84 | 918 | 400299 | 63287 | 52884562 |
Renal injury | 154.83 | 9.84 | 272 | 400945 | 9632 | 52938217 |
Drug hypersensitivity | 147.52 | 9.84 | 1280 | 399937 | 263962 | 52683887 |
Injection site erythema | 142.69 | 9.84 | 225 | 400992 | 77024 | 52870825 |
Injection site pain | 139.12 | 9.84 | 415 | 400802 | 112976 | 52834873 |
Hypomagnesaemia | 134.59 | 9.84 | 452 | 400765 | 24359 | 52923490 |
Hyponatraemia | 133.13 | 9.84 | 1325 | 399892 | 107282 | 52840567 |
Dyspnoea | 127.50 | 9.84 | 5504 | 395713 | 580728 | 52367121 |
Peripheral swelling | 124.85 | 9.84 | 2211 | 399006 | 203897 | 52743952 |
Injection site reaction | 122.74 | 9.84 | 122 | 401095 | 51044 | 52896805 |
Ill-defined disorder | 122.50 | 9.84 | 712 | 400505 | 48732 | 52899117 |
Gastrointestinal disorder | 122.15 | 9.84 | 1122 | 400095 | 88882 | 52858967 |
Intentional overdose | 118.28 | 9.84 | 202 | 401015 | 67003 | 52880846 |
Muscle spasticity | 117.93 | 9.84 | 348 | 400869 | 17490 | 52930359 |
Drug intolerance | 112.26 | 9.84 | 996 | 400221 | 204497 | 52743352 |
Alopecia | 110.46 | 9.84 | 1179 | 400038 | 233404 | 52714445 |
Asthenia | 106.57 | 9.84 | 3358 | 397859 | 340232 | 52607617 |
Stomatitis | 104.97 | 9.84 | 1165 | 400052 | 96993 | 52850856 |
Tubulointerstitial nephritis | 104.40 | 9.84 | 317 | 400900 | 16187 | 52931662 |
Labelled drug-drug interaction medication error | 104.17 | 9.84 | 244 | 400973 | 10655 | 52937194 |
Blister | 101.48 | 9.84 | 971 | 400246 | 77782 | 52870067 |
Orthostatic intolerance | 91.11 | 9.84 | 74 | 401143 | 1119 | 52946730 |
Body temperature increased | 91.01 | 9.84 | 487 | 400730 | 32312 | 52915537 |
Abdominal pain | 90.92 | 9.84 | 2544 | 398673 | 253359 | 52694490 |
Wrong technique in product usage process | 90.35 | 9.84 | 198 | 401019 | 59834 | 52888015 |
Ear pain | 89.54 | 9.84 | 451 | 400766 | 29222 | 52918627 |
Product monitoring error | 89.30 | 9.84 | 110 | 401107 | 2807 | 52945042 |
Hypokalaemia | 88.38 | 9.84 | 1112 | 400105 | 95405 | 52852444 |
Melaena | 88.09 | 9.84 | 443 | 400774 | 28686 | 52919163 |
Hepatic function abnormal | 87.34 | 9.84 | 89 | 401128 | 36810 | 52911039 |
Haematemesis | 86.87 | 9.84 | 460 | 400757 | 30397 | 52917452 |
Pemphigus | 84.18 | 9.84 | 449 | 400768 | 103582 | 52844267 |
Night sweats | 83.82 | 9.84 | 499 | 400718 | 34448 | 52913401 |
Systemic lupus erythematosus | 82.80 | 9.84 | 577 | 400640 | 124837 | 52823012 |
Systemic infection | 82.58 | 9.84 | 91 | 401126 | 2054 | 52945795 |
Injection site swelling | 80.77 | 9.84 | 122 | 401095 | 42506 | 52905343 |
Drug abuse | 78.06 | 9.84 | 243 | 400974 | 65283 | 52882566 |
No adverse event | 77.71 | 9.84 | 109 | 401108 | 39156 | 52908693 |
Confusional state | 76.15 | 9.84 | 1956 | 399261 | 192265 | 52755584 |
Product dose omission issue | 75.21 | 9.84 | 1002 | 400215 | 190618 | 52757231 |
Injection site pruritus | 73.17 | 9.84 | 125 | 401092 | 41464 | 52906385 |
Pruritus | 72.10 | 9.84 | 2796 | 398421 | 291036 | 52656813 |
Hypocalcaemia | 71.71 | 9.84 | 421 | 400796 | 28916 | 52918933 |
Gastrointestinal haemorrhage | 68.27 | 9.84 | 913 | 400304 | 79417 | 52868432 |
Foetal exposure during pregnancy | 66.11 | 9.84 | 99 | 401118 | 34616 | 52913233 |
Gastritis | 66.01 | 9.84 | 483 | 400734 | 35751 | 52912098 |
Subacute cutaneous lupus erythematosus | 65.67 | 9.84 | 85 | 401132 | 2283 | 52945566 |
Therapeutic product effect incomplete | 65.24 | 9.84 | 413 | 400804 | 91371 | 52856478 |
Sinusitis | 65.00 | 9.84 | 1694 | 399523 | 166870 | 52780979 |
Drug resistance | 64.18 | 9.84 | 35 | 401182 | 19927 | 52927922 |
Respiratory arrest | 63.53 | 9.84 | 96 | 401121 | 33444 | 52914405 |
Agranulocytosis | 63.43 | 9.84 | 349 | 400868 | 23400 | 52924449 |
Cardio-respiratory arrest | 63.08 | 9.84 | 228 | 400989 | 58530 | 52889319 |
Therapeutic response decreased | 57.66 | 9.84 | 175 | 401042 | 47394 | 52900455 |
Accidental exposure to product | 57.29 | 9.84 | 56 | 401161 | 23618 | 52924231 |
Respiratory disorder | 56.22 | 9.84 | 444 | 400773 | 33653 | 52914196 |
Leukopenia | 55.98 | 9.84 | 819 | 400398 | 72644 | 52875205 |
Premature delivery | 55.19 | 9.84 | 69 | 401148 | 26035 | 52921814 |
Foetal death | 54.84 | 9.84 | 4 | 401213 | 9343 | 52938506 |
Renal failure | 52.41 | 9.84 | 1213 | 400004 | 117239 | 52830610 |
Seizure | 51.95 | 9.84 | 674 | 400543 | 128835 | 52819014 |
Suicidal ideation | 51.85 | 9.84 | 256 | 400961 | 60255 | 52887594 |
Blood loss anaemia | 51.67 | 9.84 | 165 | 401052 | 8658 | 52939191 |
Hypoaesthesia | 51.22 | 9.84 | 698 | 400519 | 132297 | 52815552 |
Gastroenteritis clostridial | 51.14 | 9.84 | 41 | 401176 | 608 | 52947241 |
Faecaloma | 49.07 | 9.84 | 155 | 401062 | 8086 | 52939763 |
Overdose | 47.64 | 9.84 | 549 | 400668 | 107187 | 52840662 |
Anaphylactic reaction | 47.57 | 9.84 | 251 | 400966 | 58075 | 52889774 |
Neuropathy peripheral | 47.13 | 9.84 | 522 | 400695 | 102665 | 52845184 |
Abdominal discomfort | 46.46 | 9.84 | 1286 | 399931 | 219776 | 52728073 |
Musculoskeletal stiffness | 46.24 | 9.84 | 651 | 400566 | 122717 | 52825132 |
Injection site bruising | 45.26 | 9.84 | 139 | 401078 | 37507 | 52910342 |
Product use in unapproved indication | 45.17 | 9.84 | 584 | 400633 | 111705 | 52836144 |
Pneumonia viral | 44.41 | 9.84 | 136 | 401081 | 6976 | 52940873 |
Caesarean section | 44.24 | 9.84 | 39 | 401178 | 17281 | 52930568 |
Loss of personal independence in daily activities | 44.21 | 9.84 | 325 | 400892 | 69490 | 52878359 |
Pallor | 43.78 | 9.84 | 332 | 400885 | 24850 | 52922999 |
Product quality issue | 43.59 | 9.84 | 138 | 401079 | 36885 | 52910964 |
Gastrooesophageal reflux disease | 43.47 | 9.84 | 868 | 400349 | 81795 | 52866054 |
Depression | 42.93 | 9.84 | 1048 | 400169 | 182004 | 52765845 |
Sedation complication | 42.23 | 9.84 | 3 | 401214 | 7163 | 52940686 |
Rebound acid hypersecretion | 42.10 | 9.84 | 28 | 401189 | 305 | 52947544 |
Feeling abnormal | 41.63 | 9.84 | 741 | 400476 | 134560 | 52813289 |
Infection | 41.06 | 9.84 | 1634 | 399583 | 170571 | 52777278 |
Breast cancer | 41.04 | 9.84 | 211 | 401006 | 49147 | 52898702 |
Glossodynia | 40.93 | 9.84 | 520 | 400697 | 99771 | 52848078 |
Intentional self-injury | 40.90 | 9.84 | 80 | 401137 | 25204 | 52922645 |
Electrolyte imbalance | 40.48 | 9.84 | 262 | 400955 | 18622 | 52929227 |
Product use issue | 40.29 | 9.84 | 773 | 400444 | 138811 | 52809038 |
Hypertensive nephropathy | 39.91 | 9.84 | 31 | 401186 | 438 | 52947411 |
Stillbirth | 39.61 | 9.84 | 3 | 401214 | 6794 | 52941055 |
Knee arthroplasty | 39.61 | 9.84 | 125 | 401092 | 33444 | 52914405 |
Malaise | 39.55 | 9.84 | 2243 | 398974 | 355374 | 52592475 |
Intentional product misuse | 39.48 | 9.84 | 214 | 401003 | 49178 | 52898671 |
Adverse drug reaction | 38.24 | 9.84 | 241 | 400976 | 53384 | 52894465 |
Arthropathy | 38.22 | 9.84 | 792 | 400425 | 140661 | 52807188 |
Hip arthroplasty | 37.85 | 9.84 | 97 | 401120 | 27765 | 52920084 |
Coma | 37.51 | 9.84 | 291 | 400926 | 61492 | 52886357 |
Pyrexia | 37.43 | 9.84 | 3519 | 397698 | 399674 | 52548175 |
Irritability | 37.42 | 9.84 | 114 | 401103 | 30839 | 52917010 |
Device issue | 37.27 | 9.84 | 66 | 401151 | 21592 | 52926257 |
Psoriasis | 37.25 | 9.84 | 447 | 400770 | 86642 | 52861207 |
Soft tissue disorder | 36.67 | 9.84 | 92 | 401125 | 4198 | 52943651 |
Hand deformity | 36.49 | 9.84 | 435 | 400782 | 84414 | 52863435 |
Vomiting | 36.42 | 9.84 | 4270 | 396947 | 492869 | 52454980 |
Clostridium difficile colitis | 36.30 | 9.84 | 264 | 400953 | 19501 | 52928348 |
Eosinophilia | 35.82 | 9.84 | 279 | 400938 | 21056 | 52926793 |
Polyneuropathy | 35.70 | 9.84 | 195 | 401022 | 13038 | 52934811 |
Haemoglobin decreased | 35.12 | 9.84 | 1313 | 399904 | 135994 | 52811855 |
Device difficult to use | 35.03 | 9.84 | 17 | 401200 | 10342 | 52937507 |
Dystonia | 34.88 | 9.84 | 28 | 401189 | 12993 | 52934856 |
Live birth | 34.87 | 9.84 | 37 | 401180 | 15022 | 52932827 |
Adverse event | 34.44 | 9.84 | 175 | 401042 | 40886 | 52906963 |
Disease progression | 34.00 | 9.84 | 550 | 400667 | 101370 | 52846479 |
Sedation | 33.97 | 9.84 | 112 | 401105 | 29563 | 52918286 |
Genital haemorrhage | 33.91 | 9.84 | 6 | 401211 | 7038 | 52940811 |
Drug dependence | 33.82 | 9.84 | 69 | 401148 | 21403 | 52926446 |
Injection site warmth | 33.52 | 9.84 | 34 | 401183 | 14094 | 52933755 |
Dehydration | 33.44 | 9.84 | 1568 | 399649 | 166842 | 52781007 |
Haematoma | 33.15 | 9.84 | 395 | 400822 | 33449 | 52914400 |
Angina pectoris | 33.03 | 9.84 | 346 | 400871 | 28379 | 52919470 |
White blood cell count decreased | 33.02 | 9.84 | 699 | 400518 | 123776 | 52824073 |
Therapeutic drug monitoring analysis not performed | 32.91 | 9.84 | 34 | 401183 | 711 | 52947138 |
Product used for unknown indication | 32.84 | 9.84 | 33 | 401184 | 667 | 52947182 |
Pre-eclampsia | 32.76 | 9.84 | 12 | 401205 | 8635 | 52939214 |
Mycotic allergy | 32.75 | 9.84 | 37 | 401180 | 859 | 52946990 |
Weight increased | 32.57 | 9.84 | 1865 | 399352 | 202702 | 52745147 |
Gestational diabetes | 32.47 | 9.84 | 10 | 401207 | 8029 | 52939820 |
Hypoparathyroidism secondary | 32.47 | 9.84 | 13 | 401204 | 41 | 52947808 |
Restlessness | 31.67 | 9.84 | 337 | 400880 | 27750 | 52920099 |
Atrial fibrillation | 31.58 | 9.84 | 1080 | 400137 | 110572 | 52837277 |
Blood parathyroid hormone decreased | 31.26 | 9.84 | 5 | 401212 | 6313 | 52941536 |
Therapy non-responder | 30.93 | 9.84 | 229 | 400988 | 48891 | 52898958 |
Normal newborn | 30.72 | 9.84 | 8 | 401209 | 7171 | 52940678 |
Neutropenic sepsis | 30.68 | 9.84 | 39 | 401178 | 14610 | 52933239 |
Infusion related reaction | 30.53 | 9.84 | 916 | 400301 | 155041 | 52792808 |
Fall | 30.11 | 9.84 | 3107 | 398110 | 355333 | 52592516 |
Contusion | 30.05 | 9.84 | 1066 | 400151 | 109666 | 52838183 |
Flushing | 29.95 | 9.84 | 363 | 400854 | 70237 | 52877612 |
Painful respiration | 29.94 | 9.84 | 64 | 401153 | 2626 | 52945223 |
Drug eruption | 29.92 | 9.84 | 93 | 401124 | 25001 | 52922848 |
Anxiety | 29.58 | 9.84 | 1194 | 400023 | 195510 | 52752339 |
Cardiac arrest | 29.44 | 9.84 | 511 | 400706 | 93156 | 52854693 |
Eructation | 29.29 | 9.84 | 127 | 401090 | 7728 | 52940121 |
Neutrophil count decreased | 28.99 | 9.84 | 233 | 400984 | 48865 | 52898984 |
Duodenitis | 28.83 | 9.84 | 74 | 401143 | 3425 | 52944424 |
Drug reaction with eosinophilia and systemic symptoms | 28.77 | 9.84 | 375 | 400842 | 32425 | 52915424 |
Dyspepsia | 28.76 | 9.84 | 776 | 400441 | 76824 | 52871025 |
Gamma-glutamyltransferase increased | 28.75 | 9.84 | 382 | 400835 | 33173 | 52914676 |
Uterine perforation | 28.61 | 9.84 | 10 | 401207 | 7409 | 52940440 |
Device dislocation | 28.46 | 9.84 | 87 | 401130 | 23510 | 52924339 |
Premature baby | 28.41 | 9.84 | 67 | 401150 | 19734 | 52928115 |
Abnormal behaviour | 28.28 | 9.84 | 78 | 401139 | 21788 | 52926061 |
Cellulitis | 28.10 | 9.84 | 402 | 400815 | 75587 | 52872262 |
Abdominal pain lower | 27.98 | 9.84 | 286 | 400931 | 23307 | 52924542 |
Acute abdomen | 27.83 | 9.84 | 47 | 401170 | 1611 | 52946238 |
Hiatus hernia | 27.82 | 9.84 | 247 | 400970 | 19373 | 52928476 |
Platelet count decreased | 27.52 | 9.84 | 611 | 400606 | 107488 | 52840361 |
Pregnancy | 27.52 | 9.84 | 132 | 401085 | 31309 | 52916540 |
Product storage error | 27.45 | 9.84 | 35 | 401182 | 13095 | 52934754 |
Injection site rash | 27.22 | 9.84 | 52 | 401165 | 16527 | 52931322 |
Glomerulonephropathy | 26.92 | 9.84 | 14 | 401203 | 92 | 52947757 |
Injection site haemorrhage | 26.81 | 9.84 | 81 | 401136 | 21970 | 52925879 |
Rheumatoid factor positive | 26.45 | 9.84 | 191 | 401026 | 41007 | 52906842 |
Body temperature decreased | 26.04 | 9.84 | 214 | 401003 | 16413 | 52931436 |
Hypochromic anaemia | 25.88 | 9.84 | 49 | 401168 | 1840 | 52946009 |
Suicide attempt | 25.86 | 9.84 | 296 | 400921 | 57872 | 52889977 |
Nephrogenic anaemia | 25.83 | 9.84 | 50 | 401167 | 1909 | 52945940 |
Device use error | 25.79 | 9.84 | 5 | 401212 | 5494 | 52942355 |
Abortion induced | 25.74 | 9.84 | 26 | 401191 | 10800 | 52937049 |
Food allergy | 25.56 | 9.84 | 126 | 401091 | 8092 | 52939757 |
Cholestasis | 25.56 | 9.84 | 329 | 400888 | 28366 | 52919483 |
Drug withdrawal syndrome | 25.50 | 9.84 | 116 | 401101 | 27906 | 52919943 |
Clostridium test positive | 25.18 | 9.84 | 55 | 401162 | 2291 | 52945558 |
Cholecystitis chronic | 25.09 | 9.84 | 150 | 401067 | 10368 | 52937481 |
Joint stiffness | 24.87 | 9.84 | 130 | 401087 | 30153 | 52917696 |
Pancytopenia | 24.82 | 9.84 | 876 | 400341 | 90052 | 52857797 |
Vision blurred | 24.71 | 9.84 | 474 | 400743 | 85130 | 52862719 |
Dysuria | 24.58 | 9.84 | 343 | 400874 | 30110 | 52917739 |
Hepatitis acute | 24.46 | 9.84 | 132 | 401085 | 8784 | 52939065 |
Blood pressure systolic increased | 24.40 | 9.84 | 386 | 400831 | 34791 | 52913058 |
Brain contusion | 24.37 | 9.84 | 26 | 401191 | 565 | 52947284 |
Premature rupture of membranes | 24.24 | 9.84 | 4 | 401213 | 4936 | 52942913 |
Oesophagitis | 24.12 | 9.84 | 191 | 401026 | 14486 | 52933363 |
Urosepsis | 24.01 | 9.84 | 210 | 401007 | 16400 | 52931449 |
Diabetic nephropathy | 23.65 | 9.84 | 41 | 401176 | 1436 | 52946413 |
Breath sounds abnormal | 23.60 | 9.84 | 126 | 401091 | 8351 | 52939498 |
Pulmonary embolism | 23.45 | 9.84 | 1069 | 400148 | 113373 | 52834476 |
Febrile infection | 23.34 | 9.84 | 38 | 401179 | 1263 | 52946586 |
Colitis erosive | 23.31 | 9.84 | 12 | 401205 | 77 | 52947772 |
Drug ineffective for unapproved indication | 23.17 | 9.84 | 79 | 401138 | 20641 | 52927208 |
Somnolence | 23.14 | 9.84 | 1028 | 400189 | 166706 | 52781143 |
Temperature regulation disorder | 23.13 | 9.84 | 77 | 401140 | 4130 | 52943719 |
Injection site urticaria | 23 | 9.84 | 37 | 401180 | 12570 | 52935279 |
Hyperkalaemia | 22.87 | 9.84 | 552 | 400665 | 53704 | 52894145 |
Dysphoria | 22.81 | 9.84 | 6 | 401211 | 5343 | 52942506 |
Underdose | 22.77 | 9.84 | 84 | 401133 | 21438 | 52926411 |
Nephritis allergic | 22.43 | 9.84 | 15 | 401202 | 165 | 52947684 |
Internal haemorrhage | 22.39 | 9.84 | 82 | 401135 | 4614 | 52943235 |
Pancreatic steatosis | 22.35 | 9.84 | 34 | 401183 | 1065 | 52946784 |
Coagulation test abnormal | 22.27 | 9.84 | 28 | 401189 | 730 | 52947119 |
Device breakage | 22.27 | 9.84 | 28 | 401189 | 10539 | 52937310 |
Disseminated intravascular coagulation | 22.18 | 9.84 | 75 | 401142 | 19644 | 52928205 |
Panniculitis | 21.95 | 9.84 | 16 | 401201 | 7798 | 52940051 |
Dyspnoea exertional | 21.82 | 9.84 | 555 | 400662 | 54445 | 52893404 |
Hypertensive crisis | 21.81 | 9.84 | 185 | 401032 | 14321 | 52933528 |
Colitis ulcerative | 21.60 | 9.84 | 248 | 400969 | 20813 | 52927036 |
Synovial fluid analysis | 21.59 | 9.84 | 43 | 401174 | 1677 | 52946172 |
Urinary tract infection enterococcal | 21.59 | 9.84 | 55 | 401162 | 2534 | 52945315 |
Rapid eye movement sleep behaviour disorder | 21.55 | 9.84 | 15 | 401202 | 177 | 52947672 |
Enthesopathy | 21.54 | 9.84 | 11 | 401206 | 6500 | 52941349 |
Drug-induced liver injury | 21.51 | 9.84 | 324 | 400893 | 28909 | 52918940 |
Hepatitis cholestatic | 21.48 | 9.84 | 108 | 401109 | 6991 | 52940858 |
Syncope | 21.42 | 9.84 | 1039 | 400178 | 110954 | 52836895 |
Peripheral arterial occlusive disease | 21.41 | 9.84 | 72 | 401145 | 3882 | 52943967 |
Substance abuse | 21.26 | 9.84 | 4 | 401213 | 4490 | 52943359 |
Myelosuppression | 21.26 | 9.84 | 40 | 401177 | 12788 | 52935061 |
Haematotoxicity | 21.13 | 9.84 | 17 | 401200 | 7880 | 52939969 |
Total lung capacity decreased | 20.91 | 9.84 | 38 | 401179 | 1382 | 52946467 |
Pain in jaw | 20.91 | 9.84 | 200 | 401017 | 40469 | 52907380 |
Urinary tract obstruction | 20.90 | 9.84 | 45 | 401172 | 1856 | 52945993 |
Trimethylaminuria | 20.86 | 9.84 | 14 | 401203 | 155 | 52947694 |
Treatment noncompliance | 20.80 | 9.84 | 154 | 401063 | 32881 | 52914968 |
Thrombocytopenia | 20.77 | 9.84 | 1258 | 399959 | 137469 | 52810380 |
Fracture | 20.69 | 9.84 | 217 | 401000 | 17802 | 52930047 |
Hyperkinesia | 20.65 | 9.84 | 47 | 401170 | 2013 | 52945836 |
Sopor | 20.61 | 9.84 | 246 | 400971 | 20838 | 52927011 |
Subileus | 20.55 | 9.84 | 62 | 401155 | 3154 | 52944695 |
Cardiac failure | 20.54 | 9.84 | 815 | 400402 | 85029 | 52862820 |
Bursitis | 20.50 | 9.84 | 259 | 400958 | 22233 | 52925616 |
Balance disorder | 20.32 | 9.84 | 408 | 400809 | 72799 | 52875050 |
Somatic symptom disorder | 20.08 | 9.84 | 47 | 401170 | 2051 | 52945798 |
Oesophageal dilatation | 20.07 | 9.84 | 19 | 401198 | 356 | 52947493 |
Gastric haemorrhage | 20.03 | 9.84 | 96 | 401121 | 6095 | 52941754 |
Headache | 20.00 | 9.84 | 3644 | 397573 | 533177 | 52414672 |
Mydriasis | 19.96 | 9.84 | 34 | 401183 | 11292 | 52936557 |
Sleep disorder | 19.94 | 9.84 | 582 | 400635 | 58288 | 52889561 |
Poisoning | 19.76 | 9.84 | 47 | 401170 | 13803 | 52934046 |
Haematocrit decreased | 19.61 | 9.84 | 392 | 400825 | 36939 | 52910910 |
Neuropathy vitamin B12 deficiency | 19.49 | 9.84 | 5 | 401212 | 0 | 52947849 |
Intermenstrual bleeding | 19.44 | 9.84 | 22 | 401195 | 8676 | 52939173 |
Hepatitis B | 19.44 | 9.84 | 3 | 401214 | 3889 | 52943960 |
Pharyngeal dystonia | 19.27 | 9.84 | 6 | 401211 | 6 | 52947843 |
Shock | 19.19 | 9.84 | 99 | 401118 | 23040 | 52924809 |
Rectal haemorrhage | 19.02 | 9.84 | 427 | 400790 | 41054 | 52906795 |
Heavy menstrual bleeding | 18.92 | 9.84 | 67 | 401150 | 17309 | 52930540 |
Cachexia | 18.88 | 9.84 | 83 | 401134 | 5081 | 52942768 |
Diarrhoea | 18.83 | 9.84 | 5129 | 396088 | 620417 | 52327432 |
Gastric ulcer | 18.77 | 9.84 | 263 | 400954 | 23106 | 52924743 |
Prothrombin time shortened | 18.72 | 9.84 | 42 | 401175 | 1782 | 52946067 |
Clostridium difficile infection | 18.57 | 9.84 | 304 | 400913 | 27589 | 52920260 |
Spontaneous haemorrhage | 18.55 | 9.84 | 16 | 401201 | 264 | 52947585 |
Cerebral ischaemia | 18.51 | 9.84 | 99 | 401118 | 6566 | 52941283 |
Chronic gastritis | 18.41 | 9.84 | 51 | 401166 | 2471 | 52945378 |
Prerenal failure | 18.33 | 9.84 | 39 | 401178 | 1595 | 52946254 |
Therapeutic drug monitoring analysis incorrectly performed | 18.22 | 9.84 | 13 | 401204 | 160 | 52947689 |
Spinal pain | 18.11 | 9.84 | 149 | 401068 | 11431 | 52936418 |
Hepatic cyst | 18.04 | 9.84 | 80 | 401137 | 4916 | 52942933 |
Medication error | 17.84 | 9.84 | 378 | 400839 | 35987 | 52911862 |
Monoparesis | 17.83 | 9.84 | 38 | 401179 | 1556 | 52946293 |
Complication associated with device | 17.83 | 9.84 | 62 | 401155 | 16103 | 52931746 |
Wheelchair user | 17.78 | 9.84 | 7 | 401210 | 4819 | 52943030 |
Low birth weight baby | 17.77 | 9.84 | 13 | 401204 | 6324 | 52941525 |
Amenorrhoea | 17.47 | 9.84 | 27 | 401190 | 9322 | 52938527 |
Gastritis erosive | 17.47 | 9.84 | 86 | 401131 | 5520 | 52942329 |
Abdominal wall wound | 17.45 | 9.84 | 9 | 401208 | 58 | 52947791 |
Vaginal haemorrhage | 17.44 | 9.84 | 124 | 401093 | 26717 | 52921132 |
Hypotension | 17.43 | 9.84 | 2174 | 399043 | 251902 | 52695947 |
Maternal drugs affecting foetus | 17.43 | 9.84 | 10 | 401207 | 5536 | 52942313 |
Paresis | 17.42 | 9.84 | 47 | 401170 | 2242 | 52945607 |
Musculoskeletal disorder | 17.42 | 9.84 | 70 | 401147 | 17429 | 52930420 |
Tachyarrhythmia | 17.39 | 9.84 | 76 | 401141 | 4640 | 52943209 |
Mixed liver injury | 17.36 | 9.84 | 67 | 401150 | 3866 | 52943983 |
Tetany | 17.33 | 9.84 | 41 | 401176 | 1802 | 52946047 |
Tenosynovitis stenosans | 17.18 | 9.84 | 47 | 401170 | 2261 | 52945588 |
Reactive gastropathy | 17.13 | 9.84 | 19 | 401198 | 432 | 52947417 |
Neuroleptic malignant syndrome | 17.04 | 9.84 | 41 | 401176 | 11992 | 52935857 |
Pseudomembranous colitis | 17.01 | 9.84 | 59 | 401158 | 3232 | 52944617 |
Hepatitis | 16.85 | 9.84 | 353 | 400864 | 33541 | 52914308 |
Folate deficiency | 16.82 | 9.84 | 44 | 401173 | 2060 | 52945789 |
Biliary dyskinesia | 16.55 | 9.84 | 52 | 401165 | 2705 | 52945144 |
Pathogen resistance | 16.48 | 9.84 | 15 | 401202 | 6545 | 52941304 |
Solar urticaria | 16.39 | 9.84 | 8 | 401209 | 45 | 52947804 |
Haemarthrosis | 16.36 | 9.84 | 58 | 401159 | 3212 | 52944637 |
Carcinoid tumour of the stomach | 16.34 | 9.84 | 12 | 401205 | 155 | 52947694 |
Deafness | 16.29 | 9.84 | 70 | 401147 | 17106 | 52930743 |
Fear of injection | 16.29 | 9.84 | 11 | 401206 | 5578 | 52942271 |
Renal cyst | 16.12 | 9.84 | 125 | 401092 | 9420 | 52938429 |
Nephropathy | 16.10 | 9.84 | 82 | 401135 | 5335 | 52942514 |
Complication of device insertion | 16.04 | 9.84 | 13 | 401204 | 6004 | 52941845 |
Sensory level abnormal | 16.02 | 9.84 | 12 | 401205 | 160 | 52947689 |
Hepatic vein dilatation | 15.98 | 9.84 | 6 | 401211 | 15 | 52947834 |
Joint injury | 15.92 | 9.84 | 99 | 401118 | 22001 | 52925848 |
Agitation | 15.89 | 9.84 | 328 | 400889 | 58298 | 52889551 |
Jaundice | 15.82 | 9.84 | 318 | 400899 | 29995 | 52917854 |
Infective pulmonary exacerbation of cystic fibrosis | 15.81 | 9.84 | 38 | 401179 | 11118 | 52936731 |
Hepatocellular injury | 15.79 | 9.84 | 315 | 400902 | 29671 | 52918178 |
Serotonin syndrome | 15.73 | 9.84 | 125 | 401092 | 26281 | 52921568 |
Renal impairment | 15.72 | 9.84 | 772 | 400445 | 82546 | 52865303 |
Neutrophil function disorder | 15.71 | 9.84 | 6 | 401211 | 16 | 52947833 |
Pseudarthrosis | 15.70 | 9.84 | 18 | 401199 | 425 | 52947424 |
Strangury | 15.59 | 9.84 | 5 | 401212 | 6 | 52947843 |
Flatulence | 15.59 | 9.84 | 328 | 400889 | 31189 | 52916660 |
Arterial stenosis | 15.52 | 9.84 | 22 | 401195 | 646 | 52947203 |
Helicobacter infection | 15.43 | 9.84 | 394 | 400823 | 38675 | 52909174 |
Arterial occlusive disease | 15.41 | 9.84 | 77 | 401140 | 4972 | 52942877 |
Injection site discolouration | 15.40 | 9.84 | 19 | 401198 | 7211 | 52940638 |
Incorrect dosage administered | 15.35 | 9.84 | 39 | 401178 | 1794 | 52946055 |
Pharyngitis | 15.29 | 9.84 | 82 | 401135 | 18898 | 52928951 |
Iron deficiency anaemia | 15.29 | 9.84 | 210 | 401007 | 18370 | 52929479 |
Occupational asthma | 15.25 | 9.84 | 11 | 401206 | 138 | 52947711 |
Adenovirus infection | 15.23 | 9.84 | 3 | 401214 | 3259 | 52944590 |
Nausea | 15.20 | 9.84 | 6104 | 395113 | 749987 | 52197862 |
Patent ductus arteriosus | 15.12 | 9.84 | 6 | 401211 | 4112 | 52943737 |
Bradycardia | 15.04 | 9.84 | 666 | 400551 | 70390 | 52877459 |
Device malfunction | 14.99 | 9.84 | 65 | 401152 | 15843 | 52932006 |
Deep vein thrombosis | 14.98 | 9.84 | 765 | 400452 | 82148 | 52865701 |
Lipoedema | 14.95 | 9.84 | 13 | 401204 | 217 | 52947632 |
Depressed level of consciousness | 14.91 | 9.84 | 304 | 400913 | 54124 | 52893725 |
Nasopharyngitis | 14.86 | 9.84 | 1658 | 399559 | 190637 | 52757212 |
Clostridium colitis | 14.78 | 9.84 | 40 | 401177 | 1912 | 52945937 |
Pancreatitis | 14.76 | 9.84 | 453 | 400764 | 45689 | 52902160 |
Atelectasis | 14.72 | 9.84 | 221 | 400996 | 19705 | 52928144 |
Drug interaction | 14.69 | 9.84 | 1874 | 399343 | 217455 | 52730394 |
Pneumonia aspiration | 14.68 | 9.84 | 176 | 401041 | 34125 | 52913724 |
Poisoning deliberate | 14.59 | 9.84 | 27 | 401190 | 8686 | 52939163 |
Gastrointestinal inflammation | 14.53 | 9.84 | 72 | 401145 | 4634 | 52943215 |
Retroperitoneal haematoma | 14.44 | 9.84 | 51 | 401166 | 2819 | 52945030 |
Post procedural pulmonary embolism | 14.29 | 9.84 | 14 | 401203 | 274 | 52947575 |
Condition aggravated | 14.22 | 9.84 | 1988 | 399229 | 295146 | 52652703 |
Pleural effusion | 14.15 | 9.84 | 808 | 400409 | 87771 | 52860078 |
Nightmare | 14.13 | 9.84 | 77 | 401140 | 17674 | 52930175 |
Salpingo-oophorectomy unilateral | 14.11 | 9.84 | 21 | 401196 | 645 | 52947204 |
Toothache | 14.10 | 9.84 | 78 | 401139 | 17836 | 52930013 |
Musculoskeletal pain | 14.03 | 9.84 | 696 | 400521 | 74504 | 52873345 |
Device deployment issue | 14.02 | 9.84 | 5 | 401212 | 3659 | 52944190 |
Liver injury | 14.02 | 9.84 | 239 | 400978 | 21864 | 52925985 |
Dermatitis allergic | 14.01 | 9.84 | 160 | 401057 | 13408 | 52934441 |
Rash | 14.00 | 9.84 | 3055 | 398162 | 443136 | 52504713 |
Food aversion | 13.98 | 9.84 | 18 | 401199 | 481 | 52947368 |
Complication of device removal | 13.93 | 9.84 | 7 | 401210 | 4175 | 52943674 |
Hypochloraemia | 13.86 | 9.84 | 39 | 401178 | 1907 | 52945942 |
Osteomyelitis | 13.85 | 9.84 | 116 | 401101 | 24119 | 52923730 |
Mood swings | 13.84 | 9.84 | 76 | 401141 | 17410 | 52930439 |
Swelling face | 13.73 | 9.84 | 326 | 400891 | 56842 | 52891007 |
Pulmonary renal syndrome | 13.68 | 9.84 | 16 | 401201 | 386 | 52947463 |
Metabolic surgery | 13.66 | 9.84 | 27 | 401190 | 1047 | 52946802 |
Lactic acidosis | 13.64 | 9.84 | 372 | 400845 | 36881 | 52910968 |
Joint swelling | 13.64 | 9.84 | 1988 | 399229 | 232650 | 52715199 |
Intraocular pressure increased | 13.63 | 9.84 | 17 | 401200 | 6421 | 52941428 |
Megacolon | 13.61 | 9.84 | 39 | 401178 | 1927 | 52945922 |
Flank pain | 13.55 | 9.84 | 163 | 401054 | 13833 | 52934016 |
Metastases to lung | 13.51 | 9.84 | 44 | 401173 | 11660 | 52936189 |
Waist circumference increased | 13.48 | 9.84 | 23 | 401194 | 795 | 52947054 |
Diverticulum intestinal | 13.46 | 9.84 | 90 | 401127 | 6467 | 52941382 |
Hepatic enzyme abnormal | 13.46 | 9.84 | 74 | 401143 | 4960 | 52942889 |
Transaminases increased | 13.44 | 9.84 | 309 | 400908 | 29823 | 52918026 |
Anuria | 13.44 | 9.84 | 148 | 401069 | 12292 | 52935557 |
Lethargy | 13.35 | 9.84 | 305 | 400912 | 53455 | 52894394 |
Epstein-Barr virus infection | 13.32 | 9.84 | 22 | 401195 | 7396 | 52940453 |
Surgery | 13.30 | 9.84 | 165 | 401052 | 31799 | 52916050 |
Acute graft versus host disease | 13.26 | 9.84 | 8 | 401209 | 4309 | 52943540 |
Hyperplastic cholecystopathy | 13.24 | 9.84 | 9 | 401208 | 102 | 52947747 |
Cushingoid | 13.23 | 9.84 | 96 | 401121 | 7086 | 52940763 |
Tuberculosis | 13.22 | 9.84 | 41 | 401176 | 11030 | 52936819 |
Rapid correction of hyponatraemia | 13.13 | 9.84 | 10 | 401207 | 137 | 52947712 |
Injection site mass | 13.09 | 9.84 | 70 | 401147 | 16144 | 52931705 |
Hypergastrinaemia | 13.09 | 9.84 | 9 | 401208 | 104 | 52947745 |
Sacroiliitis | 13.08 | 9.84 | 45 | 401172 | 2455 | 52945394 |
Gastrointestinal toxicity | 13.06 | 9.84 | 10 | 401207 | 4752 | 52943097 |
Bicytopenia | 12.95 | 9.84 | 40 | 401177 | 2061 | 52945788 |
Carotid arteriosclerosis | 12.93 | 9.84 | 26 | 401191 | 1021 | 52946828 |
Blood pressure diastolic abnormal | 12.87 | 9.84 | 111 | 401106 | 8634 | 52939215 |
Abnormal dreams | 12.84 | 9.84 | 39 | 401178 | 10562 | 52937287 |
Red blood cell sedimentation rate increased | 12.77 | 9.84 | 142 | 401075 | 27915 | 52919934 |
Presyncope | 12.76 | 9.84 | 272 | 400945 | 25922 | 52921927 |
Synovitis | 12.75 | 9.84 | 672 | 400545 | 107221 | 52840628 |
Cerebellar ataxia | 12.75 | 9.84 | 24 | 401193 | 897 | 52946952 |
Lung opacity | 12.72 | 9.84 | 38 | 401179 | 1923 | 52945926 |
Therapeutic reaction time decreased | 12.70 | 9.84 | 30 | 401187 | 1317 | 52946532 |
Gastric polyps | 12.62 | 9.84 | 45 | 401172 | 2499 | 52945350 |
Vertigo | 12.62 | 9.84 | 529 | 400688 | 55552 | 52892297 |
Lung diffusion test abnormal | 12.60 | 9.84 | 8 | 401209 | 80 | 52947769 |
Dysphagia | 12.56 | 9.84 | 765 | 400452 | 83632 | 52864217 |
Neurotoxicity | 12.54 | 9.84 | 66 | 401151 | 15283 | 52932566 |
Productive cough | 12.51 | 9.84 | 534 | 400683 | 56195 | 52891654 |
Application site pain | 12.51 | 9.84 | 8 | 401209 | 4175 | 52943674 |
Hypomania | 12.46 | 9.84 | 11 | 401206 | 4871 | 52942978 |
Pulmonary tuberculosis | 12.45 | 9.84 | 11 | 401206 | 4870 | 52942979 |
Product administered to patient of inappropriate age | 12.45 | 9.84 | 3 | 401214 | 2833 | 52945016 |
Oedema peripheral | 12.44 | 9.84 | 1467 | 399750 | 169320 | 52778529 |
Multiple sclerosis relapse | 12.44 | 9.84 | 250 | 400967 | 44603 | 52903246 |
Renal haemangioma | 12.40 | 9.84 | 6 | 401211 | 33 | 52947816 |
Intestinal haemorrhage | 12.35 | 9.84 | 55 | 401162 | 3385 | 52944464 |
Type I hypersensitivity | 12.34 | 9.84 | 46 | 401171 | 2611 | 52945238 |
Vitamin B12 decreased | 12.31 | 9.84 | 51 | 401166 | 3041 | 52944808 |
Therapy partial responder | 12.30 | 9.84 | 17 | 401200 | 6146 | 52941703 |
Skin disorder | 12.30 | 9.84 | 124 | 401093 | 24834 | 52923015 |
Respiratory depression | 12.26 | 9.84 | 52 | 401165 | 12754 | 52935095 |
Feeling jittery | 12.26 | 9.84 | 142 | 401075 | 11941 | 52935908 |
Basal cell carcinoma | 12.24 | 9.84 | 115 | 401102 | 23354 | 52924495 |
Ear infection | 12.22 | 9.84 | 130 | 401087 | 25770 | 52922079 |
Product complaint | 12.22 | 9.84 | 49 | 401168 | 12208 | 52935641 |
Eosinophils urine present | 12.21 | 9.84 | 5 | 401212 | 17 | 52947832 |
Aortic valve stenosis | 12.13 | 9.84 | 53 | 401164 | 3235 | 52944614 |
Smear cervix abnormal | 12.12 | 9.84 | 3 | 401214 | 2783 | 52945066 |
Spigelian hernia | 12.12 | 9.84 | 6 | 401211 | 35 | 52947814 |
Thrombosis | 12.04 | 9.84 | 566 | 400651 | 60227 | 52887622 |
Haemoptysis | 12.04 | 9.84 | 286 | 400931 | 27753 | 52920096 |
Status epilepticus | 12.01 | 9.84 | 66 | 401151 | 15118 | 52932731 |
Blood iron abnormal | 11.97 | 9.84 | 5 | 401212 | 3322 | 52944527 |
Inappropriate antidiuretic hormone secretion | 11.90 | 9.84 | 168 | 401049 | 14783 | 52933066 |
Acquired diaphragmatic eventration | 11.87 | 9.84 | 14 | 401203 | 341 | 52947508 |
Oesophageal candidiasis | 11.85 | 9.84 | 76 | 401141 | 5384 | 52942465 |
Bacterial test | 11.83 | 9.84 | 28 | 401189 | 1231 | 52946618 |
Enterochromaffin cell hyperplasia | 11.83 | 9.84 | 7 | 401210 | 61 | 52947788 |
Skin test positive | 11.82 | 9.84 | 21 | 401196 | 750 | 52947099 |
Juvenile idiopathic arthritis | 11.78 | 9.84 | 10 | 401207 | 4514 | 52943335 |
Laboratory test abnormal | 11.73 | 9.84 | 122 | 401095 | 24287 | 52923562 |
Myocardial infarction | 11.71 | 9.84 | 619 | 400598 | 98735 | 52849114 |
Disorientation | 11.70 | 9.84 | 383 | 400834 | 38976 | 52908873 |
Automatism epileptic | 11.69 | 9.84 | 3 | 401214 | 0 | 52947849 |
Speech rehabilitation | 11.69 | 9.84 | 3 | 401214 | 0 | 52947849 |
Low density lipoprotein | 11.69 | 9.84 | 3 | 401214 | 0 | 52947849 |
Demyelination | 11.62 | 9.84 | 18 | 401199 | 6209 | 52941640 |
Neck pain | 11.61 | 9.84 | 353 | 400864 | 59663 | 52888186 |
Tooth disorder | 11.56 | 9.84 | 128 | 401089 | 25184 | 52922665 |
Neutropenia | 11.55 | 9.84 | 1035 | 400182 | 158150 | 52789699 |
Cholangitis acute | 11.54 | 9.84 | 16 | 401201 | 460 | 52947389 |
Breast discomfort | 11.54 | 9.84 | 16 | 401201 | 460 | 52947389 |
Akathisia | 11.52 | 9.84 | 30 | 401187 | 8541 | 52939308 |
Rash pruritic | 11.51 | 9.84 | 287 | 400930 | 49723 | 52898126 |
Lymphoproliferative disorder | 11.47 | 9.84 | 4 | 401213 | 2968 | 52944881 |
Squamous cell carcinoma of the oral cavity | 11.43 | 9.84 | 13 | 401204 | 304 | 52947545 |
Wound treatment | 11.41 | 9.84 | 11 | 401206 | 211 | 52947638 |
Cytomegalovirus infection | 11.41 | 9.84 | 93 | 401124 | 19446 | 52928403 |
Hypertransaminasaemia | 11.39 | 9.84 | 60 | 401157 | 3956 | 52943893 |
Coeliac disease | 11.39 | 9.84 | 108 | 401109 | 8627 | 52939222 |
Myeloblast percentage decreased | 11.34 | 9.84 | 6 | 401211 | 41 | 52947808 |
Wound infection fungal | 11.31 | 9.84 | 9 | 401208 | 132 | 52947717 |
Rib deformity | 11.30 | 9.84 | 10 | 401207 | 171 | 52947678 |
Abdominal distension | 11.28 | 9.84 | 720 | 400497 | 79070 | 52868779 |
Enteritis | 11.21 | 9.84 | 95 | 401122 | 7351 | 52940498 |
Nasal obstruction | 11.20 | 9.84 | 25 | 401192 | 1057 | 52946792 |
Glomerulonephritis chronic | 11.16 | 9.84 | 10 | 401207 | 174 | 52947675 |
Arterial haemorrhage | 11.13 | 9.84 | 34 | 401183 | 1742 | 52946107 |
Natural killer cell count decreased | 11.11 | 9.84 | 6 | 401211 | 43 | 52947806 |
Anal polyp | 11.11 | 9.84 | 6 | 401211 | 43 | 52947806 |
Injection site induration | 11.11 | 9.84 | 31 | 401186 | 8627 | 52939222 |
Epigastric discomfort | 11.08 | 9.84 | 82 | 401135 | 6091 | 52941758 |
Vascular stent stenosis | 11.07 | 9.84 | 17 | 401200 | 537 | 52947312 |
Duodenal polyp | 10.98 | 9.84 | 8 | 401209 | 102 | 52947747 |
Pneumocystis jirovecii pneumonia | 10.97 | 9.84 | 75 | 401142 | 16303 | 52931546 |
Iron deficiency | 10.92 | 9.84 | 83 | 401134 | 6217 | 52941632 |
Gait deviation | 10.86 | 9.84 | 7 | 401210 | 72 | 52947777 |
Blood creatinine increased | 10.80 | 9.84 | 741 | 400476 | 81921 | 52865928 |
Spontaneous haematoma | 10.77 | 9.84 | 21 | 401196 | 806 | 52947043 |
Hyperchlorhydria | 10.77 | 9.84 | 32 | 401185 | 1614 | 52946235 |
Hypophysitis | 10.76 | 9.84 | 32 | 401185 | 1615 | 52946234 |
Cytomegalovirus viraemia | 10.75 | 9.84 | 13 | 401204 | 4978 | 52942871 |
Skin necrosis | 10.71 | 9.84 | 42 | 401175 | 10530 | 52937319 |
Incorrect dose administered | 10.68 | 9.84 | 297 | 400920 | 50748 | 52897101 |
Administration site discomfort | 10.66 | 9.84 | 8 | 401209 | 107 | 52947742 |
Genital herpes simplex | 10.62 | 9.84 | 10 | 401207 | 186 | 52947663 |
Norovirus infection | 10.55 | 9.84 | 7 | 401210 | 76 | 52947773 |
Femoral hernia incarcerated | 10.50 | 9.84 | 22 | 401195 | 890 | 52946959 |
Autoimmune nephritis | 10.48 | 9.84 | 13 | 401204 | 334 | 52947515 |
White blood cell count abnormal | 10.47 | 9.84 | 15 | 401202 | 5343 | 52942506 |
Adrenocortical insufficiency acute | 10.46 | 9.84 | 30 | 401187 | 1483 | 52946366 |
Sexual dysfunction | 10.45 | 9.84 | 6 | 401211 | 3320 | 52944529 |
Migraine | 10.44 | 9.84 | 496 | 400721 | 79921 | 52867928 |
Metastases to bone | 10.39 | 9.84 | 94 | 401123 | 19234 | 52928615 |
Tricuspid valve incompetence | 10.38 | 9.84 | 159 | 401058 | 14237 | 52933612 |
Duodenal ulcer perforation | 10.36 | 9.84 | 342 | 400875 | 34841 | 52913008 |
Injection site irritation | 10.34 | 9.84 | 11 | 401206 | 4461 | 52943388 |
Ureteric stenosis | 10.31 | 9.84 | 18 | 401199 | 634 | 52947215 |
Conjunctivitis | 10.30 | 9.84 | 183 | 401034 | 16874 | 52930975 |
Incorrect product administration duration | 10.26 | 9.84 | 43 | 401174 | 10581 | 52937268 |
C-reactive protein increased | 10.22 | 9.84 | 616 | 400601 | 67270 | 52880579 |
Neurofibrosarcoma | 10.22 | 9.84 | 9 | 401208 | 153 | 52947696 |
Faecal calprotectin increased | 10.21 | 9.84 | 37 | 401180 | 2071 | 52945778 |
Anal haemorrhage | 10.19 | 9.84 | 32 | 401185 | 1664 | 52946185 |
Premature labour | 10.19 | 9.84 | 53 | 401164 | 12309 | 52935540 |
Grunting | 10.17 | 9.84 | 11 | 401206 | 243 | 52947606 |
Microgenia | 10.14 | 9.84 | 4 | 401213 | 12 | 52947837 |
Lung adenocarcinoma stage III | 10.14 | 9.84 | 4 | 401213 | 12 | 52947837 |
Amnesia | 10.13 | 9.84 | 261 | 400956 | 45027 | 52902822 |
Hepatic steatosis | 10.13 | 9.84 | 264 | 400953 | 25995 | 52921854 |
Unevaluable event | 10.10 | 9.84 | 289 | 400928 | 49209 | 52898640 |
White matter lesion | 10.09 | 9.84 | 31 | 401186 | 1593 | 52946256 |
Cholecystitis | 10.09 | 9.84 | 166 | 401051 | 15080 | 52932769 |
Maternal exposure before pregnancy | 10.08 | 9.84 | 17 | 401200 | 5669 | 52942180 |
Psychomotor retardation | 10.08 | 9.84 | 54 | 401163 | 3584 | 52944265 |
Tongue disorder | 10.06 | 9.84 | 34 | 401183 | 8907 | 52938942 |
Rhabdomyolysis | 10.04 | 9.84 | 415 | 400802 | 43508 | 52904341 |
Neurosensory hypoacusis | 10.02 | 9.84 | 12 | 401205 | 297 | 52947552 |
Glomerular filtration rate decreased | 9.98 | 9.84 | 143 | 401074 | 12624 | 52935225 |
Multiple sclerosis | 9.91 | 9.84 | 144 | 401073 | 27009 | 52920840 |
Iliac artery occlusion | 9.89 | 9.84 | 9 | 401208 | 160 | 52947689 |
Dyskinesia | 9.89 | 9.84 | 174 | 401043 | 31659 | 52916190 |
Erysipelas | 9.88 | 9.84 | 91 | 401126 | 7210 | 52940639 |
Lipase increased | 9.87 | 9.84 | 111 | 401106 | 9267 | 52938582 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
General physical health deterioration | 837.80 | 10.83 | 2389 | 253165 | 112870 | 32145102 |
Toxicity to various agents | 408.52 | 10.83 | 479 | 255075 | 177562 | 32080410 |
Drug ineffective | 405.42 | 10.83 | 1599 | 253955 | 381878 | 31876094 |
Completed suicide | 360.51 | 10.83 | 138 | 255416 | 92379 | 32165593 |
Chronic kidney disease | 298.81 | 10.83 | 838 | 254716 | 39137 | 32218835 |
Hypomagnesaemia | 246.50 | 10.83 | 491 | 255063 | 18314 | 32239658 |
Drug abuse | 216.75 | 10.83 | 187 | 255367 | 80056 | 32177916 |
Product prescribing error | 204.40 | 10.83 | 468 | 255086 | 19249 | 32238723 |
Haematochezia | 187.73 | 10.83 | 706 | 254848 | 38502 | 32219470 |
Anaemia | 175.06 | 10.83 | 2595 | 252959 | 221029 | 32036943 |
Death | 146.37 | 10.83 | 2123 | 253431 | 380394 | 31877578 |
Systemic infection | 138.43 | 10.83 | 124 | 255430 | 2059 | 32255913 |
Hypocalcaemia | 128.15 | 10.83 | 436 | 255118 | 22618 | 32235354 |
End stage renal disease | 127.86 | 10.83 | 228 | 255326 | 7809 | 32250163 |
Foetal exposure during pregnancy | 121.86 | 10.83 | 88 | 255466 | 41213 | 32216759 |
Hepatic function abnormal | 114.47 | 10.83 | 110 | 255444 | 44730 | 32213242 |
Product monitoring error | 84.88 | 10.83 | 103 | 255451 | 2471 | 32255501 |
Acute kidney injury | 84.45 | 10.83 | 2955 | 252599 | 290513 | 31967459 |
Renal injury | 83.50 | 10.83 | 246 | 255308 | 11809 | 32246163 |
Cholestasis | 82.20 | 10.83 | 425 | 255129 | 26608 | 32231364 |
Electrolyte imbalance | 80.38 | 10.83 | 248 | 255306 | 12214 | 32245758 |
Intentional overdose | 75.32 | 10.83 | 132 | 255422 | 41469 | 32216503 |
Dyspnoea | 73.22 | 10.83 | 3511 | 252043 | 358534 | 31899438 |
Overdose | 72.46 | 10.83 | 395 | 255159 | 86682 | 32171290 |
Melaena | 71.32 | 10.83 | 492 | 255062 | 34173 | 32223799 |
Hypokalaemia | 70.81 | 10.83 | 703 | 254851 | 54391 | 32203581 |
Syncope | 69.90 | 10.83 | 1045 | 254509 | 89079 | 32168893 |
Off label use | 68.75 | 10.83 | 1858 | 253696 | 304462 | 31953510 |
Intentional product misuse | 65.62 | 10.83 | 114 | 255440 | 35937 | 32222035 |
Drug resistance | 65.08 | 10.83 | 51 | 255503 | 22914 | 32235058 |
Haematemesis | 63.36 | 10.83 | 403 | 255151 | 27232 | 32230740 |
Neuropathy peripheral | 62.51 | 10.83 | 352 | 255202 | 76630 | 32181342 |
Blood loss anaemia | 61.49 | 10.83 | 169 | 255385 | 7793 | 32250179 |
Abdominal pain lower | 61.06 | 10.83 | 189 | 255365 | 9324 | 32248648 |
Treatment failure | 60.78 | 10.83 | 136 | 255418 | 39027 | 32218945 |
Respiratory arrest | 60.67 | 10.83 | 83 | 255471 | 28825 | 32229147 |
Abdominal pain upper | 59.90 | 10.83 | 800 | 254754 | 66538 | 32191434 |
Abdominal pain | 59.63 | 10.83 | 1568 | 253986 | 147961 | 32110011 |
Erysipelas | 58.08 | 10.83 | 123 | 255431 | 4793 | 32253179 |
Cardiac arrest | 57.09 | 10.83 | 486 | 255068 | 96290 | 32161682 |
Agranulocytosis | 56.09 | 10.83 | 346 | 255208 | 23131 | 32234841 |
Gastrointestinal haemorrhage | 54.90 | 10.83 | 974 | 254580 | 85908 | 32172064 |
Product dose omission issue | 53.21 | 10.83 | 532 | 255022 | 102043 | 32155929 |
Irritability | 51.52 | 10.83 | 71 | 255483 | 24583 | 32233389 |
Normocytic anaemia | 50.80 | 10.83 | 73 | 255481 | 2074 | 32255898 |
Oedema peripheral | 50.06 | 10.83 | 1212 | 254342 | 112879 | 32145093 |
Acute abdomen | 49.11 | 10.83 | 69 | 255485 | 1919 | 32256053 |
Abnormal behaviour | 47.88 | 10.83 | 84 | 255470 | 26382 | 32231590 |
Hepatitis cholestatic | 47.86 | 10.83 | 158 | 255396 | 8067 | 32249905 |
Cardio-respiratory arrest | 46.54 | 10.83 | 254 | 255300 | 55735 | 32202237 |
Febrile infection | 45.88 | 10.83 | 71 | 255483 | 2158 | 32255814 |
Premature baby | 45.44 | 10.83 | 47 | 255507 | 18471 | 32239501 |
Pallor | 44.28 | 10.83 | 320 | 255234 | 22561 | 32235411 |
Type I hypersensitivity | 44.04 | 10.83 | 50 | 255504 | 1115 | 32256857 |
Lower respiratory tract infection | 42.62 | 10.83 | 105 | 255449 | 29138 | 32228834 |
Hypoparathyroidism secondary | 42.60 | 10.83 | 21 | 255533 | 115 | 32257857 |
Labelled drug-drug interaction medication error | 41.87 | 10.83 | 201 | 255353 | 12212 | 32245760 |
Drug withdrawal syndrome | 41.54 | 10.83 | 59 | 255495 | 20172 | 32237800 |
Immune reconstitution inflammatory syndrome | 41.13 | 10.83 | 12 | 255542 | 9547 | 32248425 |
Feeling abnormal | 40.96 | 10.83 | 292 | 255262 | 60131 | 32197841 |
Gastrointestinal bacterial overgrowth | 40.40 | 10.83 | 18 | 255536 | 75 | 32257897 |
Rectal haemorrhage | 39.89 | 10.83 | 460 | 255094 | 36963 | 32221009 |
Infective exacerbation of chronic obstructive airways disease | 39.56 | 10.83 | 60 | 255494 | 1791 | 32256181 |
Musculoskeletal pain | 39.51 | 10.83 | 404 | 255150 | 31493 | 32226479 |
Insomnia | 39.49 | 10.83 | 553 | 255001 | 99795 | 32158177 |
Gastrooesophageal reflux disease | 39.30 | 10.83 | 432 | 255122 | 34306 | 32223666 |
Therapeutic drug monitoring analysis not performed | 38.65 | 10.83 | 32 | 255522 | 475 | 32257497 |
Neutrophil count decreased | 38.00 | 10.83 | 216 | 255338 | 46923 | 32211049 |
Subileus | 37.72 | 10.83 | 81 | 255473 | 3187 | 32254785 |
Dyspnoea exertional | 37.63 | 10.83 | 470 | 255084 | 38491 | 32219481 |
Leukopenia | 37.60 | 10.83 | 673 | 254881 | 59449 | 32198523 |
Hypoparathyroidism | 37.45 | 10.83 | 31 | 255523 | 460 | 32257512 |
Pathogen resistance | 37.30 | 10.83 | 14 | 255540 | 9496 | 32248476 |
Platelet count decreased | 37.17 | 10.83 | 655 | 254899 | 113936 | 32144036 |
Malaise | 37.16 | 10.83 | 1084 | 254470 | 176054 | 32081918 |
Gastritis | 37.04 | 10.83 | 296 | 255258 | 21531 | 32236441 |
C-reactive protein increased | 36.57 | 10.83 | 556 | 254998 | 47546 | 32210426 |
Shock haemorrhagic | 36.36 | 10.83 | 173 | 255381 | 10472 | 32247500 |
Therapeutic product effect incomplete | 36.34 | 10.83 | 184 | 255370 | 41157 | 32216815 |
Atrial fibrillation | 35.62 | 10.83 | 1184 | 254370 | 115520 | 32142452 |
Suicidal ideation | 35.50 | 10.83 | 166 | 255388 | 37917 | 32220055 |
Drug hypersensitivity | 35.47 | 10.83 | 387 | 255167 | 73013 | 32184959 |
Haematoma | 35.07 | 10.83 | 332 | 255222 | 25352 | 32232620 |
Stomatitis | 34.82 | 10.83 | 180 | 255374 | 40049 | 32217923 |
Asthenia | 34.31 | 10.83 | 2221 | 253333 | 233723 | 32024249 |
Psychotic disorder | 34.06 | 10.83 | 82 | 255472 | 22938 | 32235034 |
Mucosal haemorrhage | 34.05 | 10.83 | 52 | 255502 | 1562 | 32256410 |
Cytomegalovirus infection | 32.91 | 10.83 | 97 | 255457 | 25367 | 32232605 |
Visual acuity reduced | 32.74 | 10.83 | 49 | 255505 | 16396 | 32241576 |
Agitation | 32.59 | 10.83 | 290 | 255264 | 56946 | 32201026 |
Tachyarrhythmia | 32.29 | 10.83 | 78 | 255476 | 3321 | 32254651 |
Hypertensive nephropathy | 31.35 | 10.83 | 28 | 255526 | 463 | 32257509 |
Rash | 31.28 | 10.83 | 1336 | 254218 | 207997 | 32049975 |
Product use in unapproved indication | 31.04 | 10.83 | 490 | 255064 | 86714 | 32171258 |
Diastolic dysfunction | 30.98 | 10.83 | 101 | 255453 | 5123 | 32252849 |
Seizure | 30.76 | 10.83 | 603 | 254951 | 103251 | 32154721 |
Suicide attempt | 30.42 | 10.83 | 176 | 255378 | 38068 | 32219904 |
Cardiac failure | 29.76 | 10.83 | 937 | 254617 | 90736 | 32167236 |
Dyspnoea at rest | 29.71 | 10.83 | 75 | 255479 | 3284 | 32254688 |
Serum ferritin decreased | 29.51 | 10.83 | 29 | 255525 | 544 | 32257428 |
Exposure during pregnancy | 29.46 | 10.83 | 18 | 255536 | 9211 | 32248761 |
Interstitial lung disease | 28.95 | 10.83 | 349 | 255205 | 64652 | 32193320 |
Aggression | 28.35 | 10.83 | 187 | 255367 | 39202 | 32218770 |
Hyperlipasaemia | 28.34 | 10.83 | 28 | 255526 | 529 | 32257443 |
Sedation | 28.20 | 10.83 | 65 | 255489 | 18461 | 32239511 |
Low birth weight baby | 27.93 | 10.83 | 10 | 255544 | 6984 | 32250988 |
Liver disorder | 27.75 | 10.83 | 141 | 255413 | 31513 | 32226459 |
Fracture | 27.69 | 10.83 | 115 | 255439 | 6564 | 32251408 |
Wrong technique in product usage process | 27.53 | 10.83 | 162 | 255392 | 34897 | 32223075 |
Injection site pain | 27.45 | 10.83 | 150 | 255404 | 32908 | 32225064 |
Polyneuropathy | 27.43 | 10.83 | 188 | 255366 | 13027 | 32244945 |
Synovitis | 27.39 | 10.83 | 27 | 255527 | 10851 | 32247121 |
Troponin increased | 27.29 | 10.83 | 152 | 255402 | 9790 | 32248182 |
Haematoma muscle | 27.27 | 10.83 | 37 | 255517 | 995 | 32256977 |
Upper gastrointestinal haemorrhage | 26.24 | 10.83 | 295 | 255259 | 23554 | 32234418 |
Drug ineffective for unapproved indication | 26.22 | 10.83 | 43 | 255511 | 13869 | 32244103 |
Tetanus | 26.21 | 10.83 | 12 | 255542 | 54 | 32257918 |
Angina pectoris | 26.15 | 10.83 | 369 | 255185 | 31057 | 32226915 |
Vertigo | 25.66 | 10.83 | 298 | 255256 | 23985 | 32233987 |
Acute graft versus host disease | 25.63 | 10.83 | 9 | 255545 | 6361 | 32251611 |
Tricuspid valve incompetence | 25.50 | 10.83 | 142 | 255412 | 9145 | 32248827 |
Cerebral infarction | 25.36 | 10.83 | 121 | 255433 | 27493 | 32230479 |
Psoriasis | 25.25 | 10.83 | 236 | 255318 | 45887 | 32212085 |
Intentional self-injury | 25.24 | 10.83 | 44 | 255510 | 13856 | 32244116 |
Accidental overdose | 24.75 | 10.83 | 74 | 255480 | 19265 | 32238707 |
Chronic graft versus host disease | 24.54 | 10.83 | 3 | 255551 | 4437 | 32253535 |
Depression | 24.54 | 10.83 | 578 | 254976 | 96482 | 32161490 |
Fear of disease | 24.52 | 10.83 | 19 | 255535 | 255 | 32257717 |
Osteochondrosis | 24.43 | 10.83 | 32 | 255522 | 831 | 32257141 |
Serotonin syndrome | 23.86 | 10.83 | 74 | 255480 | 19043 | 32238929 |
Arrhythmia | 23.80 | 10.83 | 400 | 255154 | 34903 | 32223069 |
Occupational dermatitis | 23.74 | 10.83 | 12 | 255542 | 70 | 32257902 |
Lower gastrointestinal haemorrhage | 23.67 | 10.83 | 134 | 255420 | 8683 | 32249289 |
Gastritis erosive | 23.61 | 10.83 | 102 | 255452 | 5925 | 32252047 |
Nephrogenic anaemia | 23.60 | 10.83 | 54 | 255500 | 2219 | 32255753 |
Dysplastic naevus | 23.35 | 10.83 | 22 | 255532 | 391 | 32257581 |
Hyponatraemia | 23.24 | 10.83 | 758 | 254796 | 73755 | 32184217 |
Rebound acid hypersecretion | 23.21 | 10.83 | 13 | 255541 | 96 | 32257876 |
Vitamin B12 deficiency | 22.84 | 10.83 | 64 | 255490 | 2985 | 32254987 |
Disease progression | 22.59 | 10.83 | 515 | 255039 | 86347 | 32171625 |
Hydrocholecystis | 22.49 | 10.83 | 18 | 255536 | 254 | 32257718 |
Colitis microscopic | 22.43 | 10.83 | 48 | 255506 | 1884 | 32256088 |
Therapeutic response decreased | 22.41 | 10.83 | 116 | 255438 | 25804 | 32232168 |
Urticaria | 22.21 | 10.83 | 332 | 255222 | 59282 | 32198690 |
Bradyarrhythmia | 22.17 | 10.83 | 51 | 255503 | 2103 | 32255869 |
Solar lentigo | 22.12 | 10.83 | 22 | 255532 | 419 | 32257553 |
Abnormal dreams | 21.86 | 10.83 | 21 | 255533 | 8543 | 32249429 |
Degenerative mitral valve disease | 21.83 | 10.83 | 17 | 255537 | 230 | 32257742 |
Cardiac failure congestive | 21.81 | 10.83 | 504 | 255050 | 84348 | 32173624 |
Hiatus hernia | 21.80 | 10.83 | 118 | 255436 | 7518 | 32250454 |
Hypersensitivity | 21.75 | 10.83 | 321 | 255233 | 57437 | 32200535 |
Thrombocytopenia | 21.69 | 10.83 | 1397 | 254157 | 146902 | 32111070 |
Dizziness | 21.67 | 10.83 | 1921 | 253633 | 207697 | 32050275 |
Cerebellar ischaemia | 21.65 | 10.83 | 13 | 255541 | 111 | 32257861 |
Gamma-glutamyltransferase increased | 21.57 | 10.83 | 351 | 255203 | 30431 | 32227541 |
Product use issue | 21.40 | 10.83 | 289 | 255265 | 52488 | 32205484 |
Headache | 21.07 | 10.83 | 1295 | 254259 | 194902 | 32063070 |
Rheumatoid arthritis | 21.05 | 10.83 | 236 | 255318 | 44308 | 32213664 |
Peritoneal dialysis complication | 21.04 | 10.83 | 4 | 255550 | 4264 | 32253708 |
Hepatocellular injury | 20.95 | 10.83 | 297 | 255257 | 25021 | 32232951 |
Drug dependence | 20.93 | 10.83 | 104 | 255450 | 23380 | 32234592 |
Anaphylactic reaction | 20.83 | 10.83 | 145 | 255409 | 30027 | 32227945 |
Lactic acidosis | 20.81 | 10.83 | 375 | 255179 | 33161 | 32224811 |
Accidental exposure to product | 20.76 | 10.83 | 35 | 255519 | 11167 | 32246805 |
No adverse event | 20.76 | 10.83 | 84 | 255470 | 19969 | 32238003 |
Tetany | 20.75 | 10.83 | 28 | 255526 | 749 | 32257223 |
Post transplant lymphoproliferative disorder | 20.63 | 10.83 | 10 | 255544 | 5824 | 32252148 |
Memory impairment | 20.53 | 10.83 | 211 | 255343 | 40268 | 32217704 |
Injection site haemorrhage | 20.52 | 10.83 | 22 | 255532 | 8506 | 32249466 |
Aortic valve stenosis | 20.50 | 10.83 | 50 | 255504 | 2142 | 32255830 |
Anxiety | 20.47 | 10.83 | 586 | 254968 | 95419 | 32162553 |
Injection site erythema | 20.34 | 10.83 | 54 | 255500 | 14614 | 32243358 |
Microcytic anaemia | 20.25 | 10.83 | 50 | 255504 | 2159 | 32255813 |
Nightmare | 20.20 | 10.83 | 46 | 255508 | 13120 | 32244852 |
Nicotine dependence | 20.18 | 10.83 | 23 | 255531 | 515 | 32257457 |
Body temperature decreased | 20.14 | 10.83 | 152 | 255402 | 10862 | 32247110 |
Drug eruption | 20.02 | 10.83 | 80 | 255474 | 19086 | 32238886 |
Multiple-drug resistance | 19.80 | 10.83 | 3 | 255551 | 3772 | 32254200 |
Therapy partial responder | 19.77 | 10.83 | 7 | 255547 | 4923 | 32253049 |
Drug reaction with eosinophilia and systemic symptoms | 19.72 | 10.83 | 362 | 255192 | 32123 | 32225849 |
Mood swings | 19.72 | 10.83 | 21 | 255533 | 8144 | 32249828 |
Withdrawal syndrome | 19.71 | 10.83 | 41 | 255513 | 12081 | 32245891 |
Mitral valve incompetence | 19.69 | 10.83 | 191 | 255363 | 14680 | 32243292 |
Adverse event | 19.69 | 10.83 | 65 | 255489 | 16407 | 32241565 |
Photodermatosis | 19.68 | 10.83 | 22 | 255532 | 482 | 32257490 |
Paresis | 19.63 | 10.83 | 47 | 255507 | 1990 | 32255982 |
Chest injury | 19.49 | 10.83 | 40 | 255514 | 1524 | 32256448 |
Foetal malformation | 19.23 | 10.83 | 13 | 255541 | 139 | 32257833 |
Glomerular filtration rate decreased | 19.21 | 10.83 | 169 | 255385 | 12642 | 32245330 |
Eosinophilia | 19.16 | 10.83 | 289 | 255265 | 24669 | 32233303 |
Mean cell haemoglobin decreased | 19.06 | 10.83 | 37 | 255517 | 1353 | 32256619 |
Serum ferritin abnormal | 18.97 | 10.83 | 16 | 255538 | 244 | 32257728 |
Myocardial infarction | 18.96 | 10.83 | 801 | 254753 | 124875 | 32133097 |
Iron deficiency anaemia | 18.95 | 10.83 | 136 | 255418 | 9565 | 32248407 |
Peripheral arterial occlusive disease | 18.93 | 10.83 | 92 | 255462 | 5617 | 32252355 |
Urogenital haemorrhage | 18.91 | 10.83 | 22 | 255532 | 504 | 32257468 |
Disseminated intravascular coagulation | 18.78 | 10.83 | 106 | 255448 | 23070 | 32234902 |
Poisoning | 18.78 | 10.83 | 37 | 255517 | 11121 | 32246851 |
Anger | 18.74 | 10.83 | 41 | 255513 | 11863 | 32246109 |
Gravitational oedema | 18.53 | 10.83 | 24 | 255530 | 616 | 32257356 |
Autoimmune colitis | 18.40 | 10.83 | 30 | 255524 | 954 | 32257018 |
Cachexia | 18.40 | 10.83 | 107 | 255447 | 7002 | 32250970 |
Urinary hesitation | 18.39 | 10.83 | 50 | 255504 | 2291 | 32255681 |
Hallucination | 18.27 | 10.83 | 297 | 255257 | 52322 | 32205650 |
Helicobacter gastritis | 18.16 | 10.83 | 30 | 255524 | 965 | 32257007 |
Gastrointestinal angiodysplasia | 18.15 | 10.83 | 24 | 255530 | 629 | 32257343 |
Intestinal angioedema | 18.12 | 10.83 | 13 | 255541 | 154 | 32257818 |
Flushing | 18.03 | 10.83 | 157 | 255397 | 30970 | 32227002 |
Joint swelling | 17.96 | 10.83 | 292 | 255262 | 51443 | 32206529 |
Gastrointestinal pain | 17.88 | 10.83 | 57 | 255497 | 2857 | 32255115 |
Product storage error | 17.86 | 10.83 | 18 | 255536 | 7160 | 32250812 |
Product quality issue | 17.82 | 10.83 | 84 | 255470 | 19149 | 32238823 |
Lethargy | 17.73 | 10.83 | 223 | 255331 | 41005 | 32216967 |
Fall | 17.73 | 10.83 | 1781 | 253773 | 194420 | 32063552 |
Presyncope | 17.69 | 10.83 | 211 | 255343 | 17090 | 32240882 |
Victim of child abuse | 17.62 | 10.83 | 26 | 255528 | 757 | 32257215 |
Electrocardiogram QT prolonged | 17.62 | 10.83 | 422 | 255132 | 39219 | 32218753 |
Altered state of consciousness | 17.61 | 10.83 | 101 | 255453 | 21896 | 32236076 |
Bronchial wall thickening | 17.48 | 10.83 | 29 | 255525 | 936 | 32257036 |
Drug screen false positive | 17.47 | 10.83 | 26 | 255528 | 763 | 32257209 |
Miosis | 17.26 | 10.83 | 26 | 255528 | 8678 | 32249294 |
Thrombotic microangiopathy | 17.23 | 10.83 | 30 | 255524 | 9452 | 32248520 |
Right atrial hypertrophy | 17.21 | 10.83 | 17 | 255537 | 321 | 32257651 |
Occult blood | 17.20 | 10.83 | 20 | 255534 | 458 | 32257514 |
Neuroleptic malignant syndrome | 17.05 | 10.83 | 75 | 255479 | 17420 | 32240552 |
Erectile dysfunction | 17.03 | 10.83 | 89 | 255465 | 19750 | 32238222 |
Adjustment disorder | 17.02 | 10.83 | 29 | 255525 | 957 | 32257015 |
Mean cell haemoglobin concentration | 16.97 | 10.83 | 8 | 255546 | 39 | 32257933 |
Cold sweat | 16.94 | 10.83 | 135 | 255419 | 9811 | 32248161 |
Hypertrophy | 16.90 | 10.83 | 19 | 255535 | 419 | 32257553 |
Injection site swelling | 16.81 | 10.83 | 31 | 255523 | 9553 | 32248419 |
Drug use disorder | 16.61 | 10.83 | 4 | 255550 | 3617 | 32254355 |
Cytomegalovirus viraemia | 16.59 | 10.83 | 17 | 255537 | 6710 | 32251262 |
Cardiac aneurysm | 16.58 | 10.83 | 28 | 255526 | 917 | 32257055 |
Apparent death | 16.57 | 10.83 | 4 | 255550 | 3611 | 32254361 |
Base excess decreased | 16.52 | 10.83 | 14 | 255540 | 215 | 32257757 |
Perihepatic abscess | 16.50 | 10.83 | 10 | 255544 | 87 | 32257885 |
Chronic kidney disease-mineral and bone disorder | 16.44 | 10.83 | 18 | 255536 | 385 | 32257587 |
Tuberculosis | 16.43 | 10.83 | 27 | 255527 | 8702 | 32249270 |
Dermatitis infected | 16.24 | 10.83 | 11 | 255543 | 118 | 32257854 |
White blood cell count decreased | 16.22 | 10.83 | 570 | 254984 | 90628 | 32167344 |
Mania | 16.15 | 10.83 | 32 | 255522 | 9600 | 32248372 |
Jaundice | 15.91 | 10.83 | 366 | 255188 | 33792 | 32224180 |
Peritonitis bacterial | 15.86 | 10.83 | 48 | 255506 | 12448 | 32245524 |
Therapy non-responder | 15.83 | 10.83 | 172 | 255382 | 32482 | 32225490 |
Osteonecrosis | 15.75 | 10.83 | 72 | 255482 | 16550 | 32241422 |
Burns second degree | 15.62 | 10.83 | 17 | 255537 | 361 | 32257611 |
Extrapyramidal disorder | 15.59 | 10.83 | 45 | 255509 | 11850 | 32246122 |
N-terminal prohormone brain natriuretic peptide increased | 15.56 | 10.83 | 43 | 255511 | 1989 | 32255983 |
Rash maculo-papular | 15.55 | 10.83 | 308 | 255246 | 27714 | 32230258 |
Ventricular arrhythmia | 15.53 | 10.83 | 80 | 255474 | 4999 | 32252973 |
Trisomy 18 | 15.50 | 10.83 | 14 | 255540 | 235 | 32257737 |
Duodenogastric reflux | 15.42 | 10.83 | 4 | 255550 | 0 | 32257972 |
Treatment noncompliance | 15.40 | 10.83 | 138 | 255416 | 27064 | 32230908 |
Sexual dysfunction | 15.39 | 10.83 | 16 | 255538 | 6273 | 32251699 |
Acute graft versus host disease in skin | 15.36 | 10.83 | 10 | 255544 | 4947 | 32253025 |
Pericardial disease | 15.15 | 10.83 | 16 | 255538 | 328 | 32257644 |
Small for dates baby | 15.08 | 10.83 | 4 | 255550 | 3389 | 32254583 |
Benign gastrointestinal neoplasm | 15.08 | 10.83 | 11 | 255543 | 134 | 32257838 |
Blood iron decreased | 15.02 | 10.83 | 75 | 255479 | 4629 | 32253343 |
Bronchopulmonary aspergillosis | 15.02 | 10.83 | 56 | 255498 | 13631 | 32244341 |
Injection site bruising | 14.90 | 10.83 | 24 | 255530 | 7796 | 32250176 |
Hospitalisation | 14.89 | 10.83 | 283 | 255271 | 48688 | 32209284 |
Peripheral venous disease | 14.88 | 10.83 | 49 | 255505 | 2498 | 32255474 |
Subacute cutaneous lupus erythematosus | 14.86 | 10.83 | 24 | 255530 | 757 | 32257215 |
Bronchial obstruction | 14.81 | 10.83 | 38 | 255516 | 1681 | 32256291 |
Injection site phlebitis | 14.71 | 10.83 | 7 | 255547 | 35 | 32257937 |
Blood pressure fluctuation | 14.63 | 10.83 | 231 | 255323 | 19904 | 32238068 |
Device issue | 14.61 | 10.83 | 30 | 255524 | 8882 | 32249090 |
Uveitis | 14.60 | 10.83 | 17 | 255537 | 6333 | 32251639 |
Upper motor neurone lesion | 14.55 | 10.83 | 10 | 255544 | 110 | 32257862 |
Procalcitonin abnormal | 14.55 | 10.83 | 10 | 255544 | 110 | 32257862 |
Dependence on oxygen therapy | 14.45 | 10.83 | 12 | 255542 | 179 | 32257793 |
Thrombophlebitis | 14.43 | 10.83 | 55 | 255499 | 3017 | 32254955 |
Flatulence | 14.42 | 10.83 | 223 | 255331 | 19132 | 32238840 |
Hyperreflexia | 14.42 | 10.83 | 3 | 255551 | 3001 | 32254971 |
Pulpitis dental | 14.20 | 10.83 | 17 | 255537 | 402 | 32257570 |
Renal cyst | 14.12 | 10.83 | 117 | 255437 | 8602 | 32249370 |
Pulmonary valve disease | 14.02 | 10.83 | 14 | 255540 | 268 | 32257704 |
Neoplasm malignant | 13.92 | 10.83 | 89 | 255465 | 18796 | 32239176 |
Cardiotoxicity | 13.91 | 10.83 | 11 | 255543 | 4921 | 32253051 |
Mastitis | 13.91 | 10.83 | 12 | 255542 | 189 | 32257783 |
Diverticulum intestinal | 13.89 | 10.83 | 59 | 255495 | 3401 | 32254571 |
Procalcitonin increased | 13.87 | 10.83 | 37 | 255517 | 1676 | 32256296 |
Weight decreased | 13.86 | 10.83 | 1489 | 254065 | 163329 | 32094643 |
Tendonitis | 13.82 | 10.83 | 30 | 255524 | 8705 | 32249267 |
Pulmonary embolism | 13.69 | 10.83 | 796 | 254758 | 82863 | 32175109 |
Therapeutic product effect decreased | 13.62 | 10.83 | 167 | 255387 | 30850 | 32227122 |
Drug abuser | 13.58 | 10.83 | 8 | 255546 | 4176 | 32253796 |
Urinary straining | 13.54 | 10.83 | 5 | 255549 | 11 | 32257961 |
Respiratory tract haemorrhage | 13.53 | 10.83 | 27 | 255527 | 1008 | 32256964 |
Device leakage | 13.51 | 10.83 | 10 | 255544 | 4626 | 32253346 |
Thrombocytosis | 13.40 | 10.83 | 61 | 255493 | 3624 | 32254348 |
Faeces pale | 13.38 | 10.83 | 34 | 255520 | 1495 | 32256477 |
Graft versus host disease | 13.36 | 10.83 | 42 | 255512 | 10764 | 32247208 |
Leptospirosis | 13.28 | 10.83 | 6 | 255548 | 26 | 32257946 |
Puncture site haematoma | 13.19 | 10.83 | 11 | 255543 | 165 | 32257807 |
Activated partial thromboplastin time shortened | 13.18 | 10.83 | 18 | 255536 | 487 | 32257485 |
Alanine aminotransferase increased | 13.17 | 10.83 | 494 | 255060 | 77985 | 32179987 |
Exercise tolerance decreased | 13.16 | 10.83 | 71 | 255483 | 4517 | 32253455 |
Myelocyte count increased | 13.11 | 10.83 | 16 | 255538 | 386 | 32257586 |
Polypectomy | 13.09 | 10.83 | 19 | 255535 | 545 | 32257427 |
Arteriosclerotic gangrene | 13.07 | 10.83 | 8 | 255546 | 71 | 32257901 |
Fluid intake reduced | 13.06 | 10.83 | 57 | 255497 | 3325 | 32254647 |
Lichenoid keratosis | 13.03 | 10.83 | 45 | 255509 | 2351 | 32255621 |
Cellulitis | 13.00 | 10.83 | 298 | 255256 | 49932 | 32208040 |
Hypertransaminasaemia | 12.94 | 10.83 | 66 | 255488 | 4108 | 32253864 |
Tobacco abuse | 12.92 | 10.83 | 16 | 255538 | 392 | 32257580 |
Confabulation | 12.92 | 10.83 | 10 | 255544 | 134 | 32257838 |
Taste disorder | 12.91 | 10.83 | 72 | 255482 | 4639 | 32253333 |
Gastrooesophageal sphincter insufficiency | 12.89 | 10.83 | 8 | 255546 | 73 | 32257899 |
Dyskinesia | 12.82 | 10.83 | 121 | 255433 | 23482 | 32234490 |
Jejunostomy | 12.77 | 10.83 | 6 | 255548 | 29 | 32257943 |
Underdose | 12.75 | 10.83 | 56 | 255498 | 13013 | 32244959 |
Abnormal faeces | 12.74 | 10.83 | 53 | 255501 | 3027 | 32254945 |
Benign prostatic hyperplasia | 12.73 | 10.83 | 151 | 255403 | 12213 | 32245759 |
Haemophagocytic lymphohistiocytosis | 12.69 | 10.83 | 46 | 255508 | 11289 | 32246683 |
Occupational exposure to air contaminants | 12.66 | 10.83 | 9 | 255545 | 105 | 32257867 |
Hypovolaemic shock | 12.66 | 10.83 | 95 | 255459 | 6777 | 32251195 |
Paranasal sinus discomfort | 12.57 | 10.83 | 22 | 255532 | 742 | 32257230 |
COVID-19 pneumonia | 12.55 | 10.83 | 114 | 255440 | 8606 | 32249366 |
Hyperkinesia | 12.54 | 10.83 | 43 | 255511 | 2239 | 32255733 |
Rhythm idioventricular | 12.51 | 10.83 | 14 | 255540 | 307 | 32257665 |
Alveolar lung disease | 12.49 | 10.83 | 16 | 255538 | 406 | 32257566 |
Sinusitis | 12.47 | 10.83 | 207 | 255347 | 36353 | 32221619 |
Jugular vein distension | 12.43 | 10.83 | 19 | 255535 | 571 | 32257401 |
Nuchal rigidity | 12.39 | 10.83 | 17 | 255537 | 462 | 32257510 |
Incorrect dose administered | 12.39 | 10.83 | 197 | 255357 | 34831 | 32223141 |
Granulomatous dermatitis | 12.33 | 10.83 | 13 | 255541 | 266 | 32257706 |
Saliva altered | 12.31 | 10.83 | 11 | 255543 | 182 | 32257790 |
Lymph node calcification | 12.30 | 10.83 | 12 | 255542 | 223 | 32257749 |
Pneumonia cytomegaloviral | 12.30 | 10.83 | 4 | 255550 | 2968 | 32255004 |
Wound haemorrhage | 12.30 | 10.83 | 39 | 255515 | 1949 | 32256023 |
Chondrocalcinosis pyrophosphate | 12.26 | 10.83 | 24 | 255530 | 883 | 32257089 |
Xyphoid retraction | 12.26 | 10.83 | 11 | 255543 | 183 | 32257789 |
Road traffic accident | 12.26 | 10.83 | 83 | 255471 | 17298 | 32240674 |
Painful respiration | 12.20 | 10.83 | 30 | 255524 | 1292 | 32256680 |
Mood altered | 12.18 | 10.83 | 33 | 255521 | 8871 | 32249101 |
Syringe issue | 12.18 | 10.83 | 7 | 255547 | 3704 | 32254268 |
Pancreatic duct stenosis | 12.16 | 10.83 | 11 | 255543 | 185 | 32257787 |
Congenital hiatus hernia | 12.14 | 10.83 | 13 | 255541 | 271 | 32257701 |
Erythropenia | 12.13 | 10.83 | 12 | 255542 | 227 | 32257745 |
Hepatorenal syndrome | 12.13 | 10.83 | 47 | 255507 | 2598 | 32255374 |
Prolonged expiration | 12.12 | 10.83 | 11 | 255543 | 186 | 32257786 |
Phlebitis infective | 12.10 | 10.83 | 10 | 255544 | 148 | 32257824 |
Mucormycosis | 12.10 | 10.83 | 16 | 255538 | 5638 | 32252334 |
Hemiparesis | 12.09 | 10.83 | 181 | 255373 | 15426 | 32242546 |
Status epilepticus | 11.99 | 10.83 | 51 | 255503 | 11955 | 32246017 |
Disorganised speech | 11.99 | 10.83 | 21 | 255533 | 709 | 32257263 |
Myalgia | 11.98 | 10.83 | 519 | 255035 | 80711 | 32177261 |
Faecal calprotectin increased | 11.94 | 10.83 | 31 | 255523 | 1381 | 32256591 |
Medication error | 11.94 | 10.83 | 246 | 255308 | 22289 | 32235683 |
Device dependence | 11.87 | 10.83 | 6 | 255548 | 35 | 32257937 |
Pulmonary tuberculosis | 11.86 | 10.83 | 13 | 255541 | 4976 | 32252996 |
Pneumonia aspiration | 11.86 | 10.83 | 240 | 255314 | 40916 | 32217056 |
Gastrointestinal motility disorder | 11.84 | 10.83 | 43 | 255511 | 2304 | 32255668 |
Bronchial secretion retention | 11.82 | 10.83 | 26 | 255528 | 1040 | 32256932 |
Haemorrhagic disorder | 11.82 | 10.83 | 19 | 255535 | 597 | 32257375 |
Haematotoxicity | 11.81 | 10.83 | 22 | 255532 | 6754 | 32251218 |
Blood triglycerides increased | 11.77 | 10.83 | 67 | 255487 | 14552 | 32243420 |
Vision blurred | 11.76 | 10.83 | 261 | 255293 | 43925 | 32214047 |
Eosinophilic pneumonia | 11.73 | 10.83 | 52 | 255502 | 3054 | 32254918 |
Retinitis viral | 11.72 | 10.83 | 8 | 255546 | 87 | 32257885 |
Urosepsis | 11.72 | 10.83 | 144 | 255410 | 11746 | 32246226 |
Post procedural haemorrhage | 11.68 | 10.83 | 108 | 255446 | 8192 | 32249780 |
Epileptic encephalopathy | 11.67 | 10.83 | 9 | 255545 | 120 | 32257852 |
Drug intolerance | 11.64 | 10.83 | 303 | 255251 | 49932 | 32208040 |
Cytomegalovirus infection reactivation | 11.63 | 10.83 | 6 | 255548 | 3373 | 32254599 |
Substance abuse | 11.59 | 10.83 | 24 | 255530 | 7083 | 32250889 |
Splenic thrombosis | 11.58 | 10.83 | 5 | 255549 | 19 | 32257953 |
Spinal cord herniation | 11.56 | 10.83 | 3 | 255551 | 0 | 32257972 |
Blood alcohol abnormal | 11.56 | 10.83 | 3 | 255551 | 0 | 32257972 |
Bladder diverticulitis | 11.56 | 10.83 | 3 | 255551 | 0 | 32257972 |
Hypertensive crisis | 11.55 | 10.83 | 113 | 255441 | 8704 | 32249268 |
Epstein-Barr virus infection | 11.51 | 10.83 | 24 | 255530 | 7066 | 32250906 |
Pulmonary vascular disorder | 11.50 | 10.83 | 19 | 255535 | 611 | 32257361 |
Adenovirus infection | 11.47 | 10.83 | 12 | 255542 | 4692 | 32253280 |
Leptotrichia infection | 11.42 | 10.83 | 8 | 255546 | 91 | 32257881 |
Strongyloidiasis | 11.42 | 10.83 | 3 | 255551 | 2558 | 32255414 |
Clostridium difficile infection | 11.40 | 10.83 | 200 | 255354 | 17596 | 32240376 |
Scan abnormal | 11.38 | 10.83 | 5 | 255549 | 20 | 32257952 |
Renal haemangioma | 11.38 | 10.83 | 5 | 255549 | 20 | 32257952 |
Degenerative aortic valve disease | 11.38 | 10.83 | 5 | 255549 | 20 | 32257952 |
Seroma | 11.37 | 10.83 | 19 | 255535 | 617 | 32257355 |
Prothrombin time prolonged | 11.34 | 10.83 | 122 | 255432 | 9633 | 32248339 |
Acute coronary syndrome | 11.31 | 10.83 | 163 | 255391 | 13778 | 32244194 |
Muscular weakness | 11.30 | 10.83 | 428 | 255126 | 67501 | 32190471 |
Ventricular enlargement | 11.28 | 10.83 | 16 | 255538 | 449 | 32257523 |
Organic brain syndrome | 11.25 | 10.83 | 12 | 255542 | 249 | 32257723 |
Oesophageal infection | 11.25 | 10.83 | 12 | 255542 | 249 | 32257723 |
Atrial septal defect | 11.22 | 10.83 | 24 | 255530 | 7001 | 32250971 |
Peripheral paralysis | 11.22 | 10.83 | 6 | 255548 | 40 | 32257932 |
Blindness | 11.20 | 10.83 | 59 | 255495 | 13067 | 32244905 |
Chronic actinic dermatitis | 11.19 | 10.83 | 5 | 255549 | 21 | 32257951 |
Anaemia of malignant disease | 11.18 | 10.83 | 15 | 255539 | 399 | 32257573 |
Pyelitis | 11.14 | 10.83 | 8 | 255546 | 95 | 32257877 |
Pulmonary sepsis | 11.11 | 10.83 | 40 | 255514 | 2134 | 32255838 |
Autoimmune encephalopathy | 11.10 | 10.83 | 6 | 255548 | 41 | 32257931 |
Bladder tamponade | 11.07 | 10.83 | 17 | 255537 | 513 | 32257459 |
Walking aid user | 11.06 | 10.83 | 32 | 255522 | 1520 | 32256452 |
Arteriovenous fistula | 11.01 | 10.83 | 20 | 255534 | 695 | 32257277 |
Blood pressure increased | 10.95 | 10.83 | 744 | 254810 | 78610 | 32179362 |
Hallucination, auditory | 10.94 | 10.83 | 43 | 255511 | 10307 | 32247665 |
Nocardiosis | 10.93 | 10.83 | 8 | 255546 | 3723 | 32254249 |
Shock | 10.91 | 10.83 | 129 | 255425 | 23985 | 32233987 |
Intestinal haemorrhage | 10.88 | 10.83 | 54 | 255500 | 3325 | 32254647 |
Unevaluable event | 10.86 | 10.83 | 192 | 255362 | 33394 | 32224578 |
Systolic dysfunction | 10.85 | 10.83 | 41 | 255513 | 2239 | 32255733 |
Tumour pain | 10.85 | 10.83 | 25 | 255529 | 1032 | 32256940 |
Source | Code | Description |
---|---|---|
ATC | A02BC02 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Proton pump inhibitors |
ATC | A02BD04 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD11 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
FDA MoA | N0000000147 | Proton Pump Inhibitors |
FDA EPC | N0000175525 | Proton Pump Inhibitor |
MeSH PA | D000897 | Anti-Ulcer Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D054328 | Proton Pump Inhibitors |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:49200 | proton pump inhibitors |
CHEBI has role | CHEBI:49201 | anti-ulcer agents |
CHEBI has role | CHEBI:78298 | environmental contaminants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Peptic ulcer | indication | 13200003 | DOID:750 |
Erosive esophagitis | indication | 40719004 | |
Zollinger-Ellison syndrome | indication | 53132006 | DOID:0050782 |
Multiple endocrine adenomas | indication | 60549007 | |
Gastroesophageal reflux disease | indication | 235595009 | DOID:8534 |
Maintenance of Healing Erosive Esophagitis | indication | ||
Gastric Hypersecretory Conditions | indication | ||
Upper gastrointestinal hemorrhage | off-label use | 37372002 | |
Duodenal ulcer disease | off-label use | 51868009 | DOID:1724 |
Gastric ulcer | off-label use | 397825006 | DOID:10808 |
Pathological Gastric Hypersecretory Condition | off-label use | ||
Duodenal Ulcer due to H. Pylori | off-label use | ||
Prevention of NSAID-Induced Gastric Ulcer | off-label use | ||
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Pernicious anemia | contraindication | 84027009 | DOID:13381 |
Fracture of bone | contraindication | 125605004 | |
Hypomagnesemia | contraindication | 190855004 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.42 | acidic |
pKa2 | 3.58 | Basic |
pKa3 | 2.32 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 40MG BASE | PROTONIX | WYETH PHARMS | N022020 | Nov. 14, 2007 | RX | FOR SUSPENSION, DELAYED RELEASE | ORAL | 7550153 | Sept. 30, 2024 | EROSIVE ESOPHAGITIS, HYPERSECRETORY CONDITIONS INCLUDING ZOLLINGER-ELLISON SYNDROME, MAINTENANCE OF HEALING OF EROSIVE ESOPHAGITIS AND REDUCTION OF SYMPTOMS IN PATIENTS WITH GERD |
EQ 40MG BASE | PROTONIX | WYETH PHARMS | N022020 | Nov. 14, 2007 | RX | FOR SUSPENSION, DELAYED RELEASE | ORAL | 7553498 | Sept. 30, 2024 | EROSIVE ESOPHAGITIS, HYPERSECRETORY CONDITIONS INCLUDING ZOLLINGER-ELLISON SYNDROME, MAINTENANCE OF HEALING OF EROSIVE ESOPHAGITIS AND REDUCTION OF SYMPTOMS IN PATIENTS WITH GERD |
EQ 40MG BASE | PROTONIX | WYETH PHARMS | N022020 | Nov. 14, 2007 | RX | FOR SUSPENSION, DELAYED RELEASE | ORAL | 7838027 | Sept. 30, 2024 | EROSIVE ESOPHAGITIS, HYPERSECRETORY CONDITIONS INCLUDING ZOLLINGER-ELLISON SYNDROME, MAINTENANCE OF HEALING OF EROSIVE ESOPHAGITIS AND REDUCTION OF SYMPTOMS IN PATIENTS WITH GERD |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Potassium-transporting ATPase | Transporter | INHIBITOR | CHEMBL | CHEMBL | |||||
Fatty acid synthase | Enzyme | Ki | 5.39 | CHEMBL | |||||
Solute carrier family 22 member 2 | Transporter | IC50 | 5.82 | CHEMBL | |||||
Multidrug and toxin extrusion protein 1 | Transporter | IC50 | 5.55 | CHEMBL | |||||
Multidrug and toxin extrusion protein 2 | Transporter | IC50 | 4.36 | CHEMBL | |||||
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | Enzyme | IC50 | 4.20 | CHEMBL | |||||
Sodium/potassium-transporting ATPase subunit alpha-1 | Transporter | WOMBAT-PK | |||||||
Indoleamine 2,3-dioxygenase 2 | Enzyme | IC50 | 4.90 | CHEMBL | |||||
Potassium-transporting ATPase | Enzyme | IC50 | 6 | SCIENTIFIC LITERATURE |
ID | Source |
---|---|
4021208 | VUID |
N0000148654 | NUI |
D02593 | KEGG_DRUG |
164579-32-2 | SECONDARY_CAS_RN |
4021208 | VANDF |
4021209 | VANDF |
C0081876 | UMLSCUI |
CHEBI:7915 | CHEBI |
CHEMBL1502 | ChEMBL_ID |
CHEMBL3989559 | ChEMBL_ID |
CHEMBL1200408 | ChEMBL_ID |
DB00213 | DRUGBANK_ID |
D000077402 | MESH_DESCRIPTOR_UI |
4679 | PUBCHEM_CID |
7260 | IUPHAR_LIGAND_ID |
6548 | INN_ID |
D8TST4O562 | UNII |
236632 | RXNORM |
130104 | MMSL |
8654 | MMSL |
d04514 | MMSL |
006006 | NDDF |
006493 | NDDF |
009120 | NDDF |
116510001 | SNOMEDCT_US |
317317009 | SNOMEDCT_US |
395821003 | SNOMEDCT_US |
432408008 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Protonix Delayed-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0008-0841 | TABLET, DELAYED RELEASE | 40 mg | ORAL | NDA | 30 sections |
Protonix Delayed-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0008-0843 | TABLET, DELAYED RELEASE | 20 mg | ORAL | NDA | 30 sections |
Protonix Delayed-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0008-0844 | GRANULE, DELAYED RELEASE | 40 mg | ORAL | NDA | 30 sections |
Protonix I.V. | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0008-0923 | INJECTION, POWDER, FOR SOLUTION | 40 mg | INTRAVENOUS | NDA | 28 sections |
Protonix I.V. | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0008-2001 | INJECTION, POWDER, FOR SOLUTION | 40 mg | INTRAVENOUS | NDA | 27 sections |
Protonix I.V. | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0008-4001 | INJECTION, POWDER, FOR SOLUTION | 40 mg | INTRAVENOUS | NDA | 28 sections |
Pantoprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9284 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 40 mg | INTRAVENOUS | NDA | 26 sections |
Pantoprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9300 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 40 mg | INTRAVENOUS | NDA | 26 sections |
Pantoprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6688 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 28 sections |
Pantoprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6689 | TABLET, DELAYED RELEASE | 40 mg | ORAL | ANDA | 28 sections |
Pantoprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8113 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 27 sections |
Pantoprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8308 | TABLET, DELAYED RELEASE | 40 mg | ORAL | ANDA | 29 sections |
Pantoprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3232 | INJECTION, POWDER, FOR SOLUTION | 40 mg | INTRAVENOUS | ANDA | 28 sections |
Pantoprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6474 | TABLET, DELAYED RELEASE | 40 mg | ORAL | ANDA | 27 sections |
Pantoprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6870 | TABLET, DELAYED RELEASE | 40 mg | ORAL | ANDA | 27 sections |
Pantoprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-096 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 27 sections |
Pantoprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-429 | TABLET, DELAYED RELEASE | 40 mg | ORAL | ANDA | 27 sections |
PANTOPRAZOLE SODIUMDELAYED RELEASE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-635 | TABLET, DELAYED RELEASE | 20 mg | ORAL | NDA | 30 sections |
PROTONIXDELAYED-RELEASE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-939 | TABLET, DELAYED RELEASE | 20 mg | ORAL | NDA | 30 sections |
Protonix | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-108 | TABLET, DELAYED RELEASE | 40 mg | ORAL | NDA | 27 sections |
Pantoprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-771 | TABLET, DELAYED RELEASE | 40 mg | ORAL | ANDA | 28 sections |
PANTOPRAZOLE SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-712 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 26 sections |
PANTOPRAZOLE SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-713 | TABLET, DELAYED RELEASE | 40 mg | ORAL | ANDA | 26 sections |
Pantoprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-629 | TABLET, DELAYED RELEASE | 40 mg | ORAL | ANDA | 29 sections |
Pantoprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33358-536 | TABLET, DELAYED RELEASE | 20 mg | ORAL | ANDA | 28 sections |
Pantoprazole Sodium | Human Prescription Drug Label | 1 | 35573-428 | TABLET, DELAYED RELEASE | 40 mg | ORAL | ANDA | 27 sections |
PANTOPRAZOLE SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-124 | TABLET, DELAYED RELEASE | 40 mg | ORAL | ANDA | 27 sections |
PANTOPRAZOLE SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-765 | TABLET, DELAYED RELEASE | 40 mg | ORAL | ANDA | 26 sections |
PANTOPRAZOLE SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42708-104 | TABLET, DELAYED RELEASE | 40 mg | ORAL | ANDA | 29 sections |
Pantoprazole Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-618 | TABLET, DELAYED RELEASE | 40 mg | ORAL | ANDA | 27 sections |