pantoprazole Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiulcer, benzimidazole derivatives 2054 102625-70-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pantoprazole
  • pantozol
  • pantoprazole sodium
  • controloc control
  • pantoprazole sodium hydrate
  • pantoprazole sodium sesquihydrate
Pantoprazole sodium is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by covalently binding to the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus. The binding to the (H+, K+)-ATPase results in a duration of antisecretory effect that persists longer than 24 hours.
  • Molecular weight: 383.37
  • Formula: C16H15F2N3O4S
  • CLOGP: 2.11
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 86.33
  • ALOGS: -2.89
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O
40 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.74 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.20 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 2, 2000 FDA WYETH PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 749.67 9.84 2620 398597 144322 52803527
Chronic kidney disease 566.57 9.84 1102 400115 42268 52905581
Completed suicide 466.30 9.84 228 400989 137973 52809876
Toxicity to various agents 409.90 9.84 636 400581 218962 52728887
Drug ineffective 401.10 9.84 4077 397140 813168 52134681
Exposure during pregnancy 325.63 9.84 276 400941 124584 52823265
Haematochezia 284.67 9.84 831 400386 41527 52906322
Folliculitis 271.25 9.84 680 400537 31029 52916820
Muscle injury 260.58 9.84 644 400573 29122 52918727
Maternal exposure during pregnancy 246.63 9.84 499 400718 155140 52792709
Irritable bowel syndrome 218.58 9.84 774 400443 42858 52904991
Product prescribing error 206.59 9.84 503 400714 22528 52925321
Acute kidney injury 204.52 9.84 2856 398361 251012 52696837
Death 197.61 9.84 1727 399490 355505 52592344
Anaemia 177.84 9.84 2996 398221 273722 52674127
Rheumatoid arthritis 171.46 9.84 1526 399691 313005 52634844
End stage renal disease 170.35 9.84 221 400996 5950 52941899
Device expulsion 168.70 9.84 15 401202 29798 52918051
Treatment failure 162.64 9.84 463 400754 127940 52819909
Abdominal pain upper 161.66 9.84 1937 399280 164354 52783495
Off label use 160.97 9.84 2541 398676 469671 52478178
Sleep disorder due to general medical condition, insomnia type 160.03 9.84 474 400743 23875 52923974
Lower respiratory tract infection 159.26 9.84 1201 400016 89780 52858069
Abortion spontaneous 155.56 9.84 78 401139 46557 52901292
Impaired healing 154.88 9.84 918 400299 63287 52884562
Renal injury 154.83 9.84 272 400945 9632 52938217
Drug hypersensitivity 147.52 9.84 1280 399937 263962 52683887
Injection site erythema 142.69 9.84 225 400992 77024 52870825
Injection site pain 139.12 9.84 415 400802 112976 52834873
Hypomagnesaemia 134.59 9.84 452 400765 24359 52923490
Hyponatraemia 133.13 9.84 1325 399892 107282 52840567
Dyspnoea 127.50 9.84 5504 395713 580728 52367121
Peripheral swelling 124.85 9.84 2211 399006 203897 52743952
Injection site reaction 122.74 9.84 122 401095 51044 52896805
Ill-defined disorder 122.50 9.84 712 400505 48732 52899117
Gastrointestinal disorder 122.15 9.84 1122 400095 88882 52858967
Intentional overdose 118.28 9.84 202 401015 67003 52880846
Muscle spasticity 117.93 9.84 348 400869 17490 52930359
Drug intolerance 112.26 9.84 996 400221 204497 52743352
Alopecia 110.46 9.84 1179 400038 233404 52714445
Asthenia 106.57 9.84 3358 397859 340232 52607617
Stomatitis 104.97 9.84 1165 400052 96993 52850856
Tubulointerstitial nephritis 104.40 9.84 317 400900 16187 52931662
Labelled drug-drug interaction medication error 104.17 9.84 244 400973 10655 52937194
Blister 101.48 9.84 971 400246 77782 52870067
Orthostatic intolerance 91.11 9.84 74 401143 1119 52946730
Body temperature increased 91.01 9.84 487 400730 32312 52915537
Abdominal pain 90.92 9.84 2544 398673 253359 52694490
Wrong technique in product usage process 90.35 9.84 198 401019 59834 52888015
Ear pain 89.54 9.84 451 400766 29222 52918627
Product monitoring error 89.30 9.84 110 401107 2807 52945042
Hypokalaemia 88.38 9.84 1112 400105 95405 52852444
Melaena 88.09 9.84 443 400774 28686 52919163
Hepatic function abnormal 87.34 9.84 89 401128 36810 52911039
Haematemesis 86.87 9.84 460 400757 30397 52917452
Pemphigus 84.18 9.84 449 400768 103582 52844267
Night sweats 83.82 9.84 499 400718 34448 52913401
Systemic lupus erythematosus 82.80 9.84 577 400640 124837 52823012
Systemic infection 82.58 9.84 91 401126 2054 52945795
Injection site swelling 80.77 9.84 122 401095 42506 52905343
Drug abuse 78.06 9.84 243 400974 65283 52882566
No adverse event 77.71 9.84 109 401108 39156 52908693
Confusional state 76.15 9.84 1956 399261 192265 52755584
Product dose omission issue 75.21 9.84 1002 400215 190618 52757231
Injection site pruritus 73.17 9.84 125 401092 41464 52906385
Pruritus 72.10 9.84 2796 398421 291036 52656813
Hypocalcaemia 71.71 9.84 421 400796 28916 52918933
Gastrointestinal haemorrhage 68.27 9.84 913 400304 79417 52868432
Foetal exposure during pregnancy 66.11 9.84 99 401118 34616 52913233
Gastritis 66.01 9.84 483 400734 35751 52912098
Subacute cutaneous lupus erythematosus 65.67 9.84 85 401132 2283 52945566
Therapeutic product effect incomplete 65.24 9.84 413 400804 91371 52856478
Sinusitis 65.00 9.84 1694 399523 166870 52780979
Drug resistance 64.18 9.84 35 401182 19927 52927922
Respiratory arrest 63.53 9.84 96 401121 33444 52914405
Agranulocytosis 63.43 9.84 349 400868 23400 52924449
Cardio-respiratory arrest 63.08 9.84 228 400989 58530 52889319
Therapeutic response decreased 57.66 9.84 175 401042 47394 52900455
Accidental exposure to product 57.29 9.84 56 401161 23618 52924231
Respiratory disorder 56.22 9.84 444 400773 33653 52914196
Leukopenia 55.98 9.84 819 400398 72644 52875205
Premature delivery 55.19 9.84 69 401148 26035 52921814
Foetal death 54.84 9.84 4 401213 9343 52938506
Renal failure 52.41 9.84 1213 400004 117239 52830610
Seizure 51.95 9.84 674 400543 128835 52819014
Suicidal ideation 51.85 9.84 256 400961 60255 52887594
Blood loss anaemia 51.67 9.84 165 401052 8658 52939191
Hypoaesthesia 51.22 9.84 698 400519 132297 52815552
Gastroenteritis clostridial 51.14 9.84 41 401176 608 52947241
Faecaloma 49.07 9.84 155 401062 8086 52939763
Overdose 47.64 9.84 549 400668 107187 52840662
Anaphylactic reaction 47.57 9.84 251 400966 58075 52889774
Neuropathy peripheral 47.13 9.84 522 400695 102665 52845184
Abdominal discomfort 46.46 9.84 1286 399931 219776 52728073
Musculoskeletal stiffness 46.24 9.84 651 400566 122717 52825132
Injection site bruising 45.26 9.84 139 401078 37507 52910342
Product use in unapproved indication 45.17 9.84 584 400633 111705 52836144
Pneumonia viral 44.41 9.84 136 401081 6976 52940873
Caesarean section 44.24 9.84 39 401178 17281 52930568
Loss of personal independence in daily activities 44.21 9.84 325 400892 69490 52878359
Pallor 43.78 9.84 332 400885 24850 52922999
Product quality issue 43.59 9.84 138 401079 36885 52910964
Gastrooesophageal reflux disease 43.47 9.84 868 400349 81795 52866054
Depression 42.93 9.84 1048 400169 182004 52765845
Sedation complication 42.23 9.84 3 401214 7163 52940686
Rebound acid hypersecretion 42.10 9.84 28 401189 305 52947544
Feeling abnormal 41.63 9.84 741 400476 134560 52813289
Infection 41.06 9.84 1634 399583 170571 52777278
Breast cancer 41.04 9.84 211 401006 49147 52898702
Glossodynia 40.93 9.84 520 400697 99771 52848078
Intentional self-injury 40.90 9.84 80 401137 25204 52922645
Electrolyte imbalance 40.48 9.84 262 400955 18622 52929227
Product use issue 40.29 9.84 773 400444 138811 52809038
Hypertensive nephropathy 39.91 9.84 31 401186 438 52947411
Stillbirth 39.61 9.84 3 401214 6794 52941055
Knee arthroplasty 39.61 9.84 125 401092 33444 52914405
Malaise 39.55 9.84 2243 398974 355374 52592475
Intentional product misuse 39.48 9.84 214 401003 49178 52898671
Adverse drug reaction 38.24 9.84 241 400976 53384 52894465
Arthropathy 38.22 9.84 792 400425 140661 52807188
Hip arthroplasty 37.85 9.84 97 401120 27765 52920084
Coma 37.51 9.84 291 400926 61492 52886357
Pyrexia 37.43 9.84 3519 397698 399674 52548175
Irritability 37.42 9.84 114 401103 30839 52917010
Device issue 37.27 9.84 66 401151 21592 52926257
Psoriasis 37.25 9.84 447 400770 86642 52861207
Soft tissue disorder 36.67 9.84 92 401125 4198 52943651
Hand deformity 36.49 9.84 435 400782 84414 52863435
Vomiting 36.42 9.84 4270 396947 492869 52454980
Clostridium difficile colitis 36.30 9.84 264 400953 19501 52928348
Eosinophilia 35.82 9.84 279 400938 21056 52926793
Polyneuropathy 35.70 9.84 195 401022 13038 52934811
Haemoglobin decreased 35.12 9.84 1313 399904 135994 52811855
Device difficult to use 35.03 9.84 17 401200 10342 52937507
Dystonia 34.88 9.84 28 401189 12993 52934856
Live birth 34.87 9.84 37 401180 15022 52932827
Adverse event 34.44 9.84 175 401042 40886 52906963
Disease progression 34.00 9.84 550 400667 101370 52846479
Sedation 33.97 9.84 112 401105 29563 52918286
Genital haemorrhage 33.91 9.84 6 401211 7038 52940811
Drug dependence 33.82 9.84 69 401148 21403 52926446
Injection site warmth 33.52 9.84 34 401183 14094 52933755
Dehydration 33.44 9.84 1568 399649 166842 52781007
Haematoma 33.15 9.84 395 400822 33449 52914400
Angina pectoris 33.03 9.84 346 400871 28379 52919470
White blood cell count decreased 33.02 9.84 699 400518 123776 52824073
Therapeutic drug monitoring analysis not performed 32.91 9.84 34 401183 711 52947138
Product used for unknown indication 32.84 9.84 33 401184 667 52947182
Pre-eclampsia 32.76 9.84 12 401205 8635 52939214
Mycotic allergy 32.75 9.84 37 401180 859 52946990
Weight increased 32.57 9.84 1865 399352 202702 52745147
Gestational diabetes 32.47 9.84 10 401207 8029 52939820
Hypoparathyroidism secondary 32.47 9.84 13 401204 41 52947808
Restlessness 31.67 9.84 337 400880 27750 52920099
Atrial fibrillation 31.58 9.84 1080 400137 110572 52837277
Blood parathyroid hormone decreased 31.26 9.84 5 401212 6313 52941536
Therapy non-responder 30.93 9.84 229 400988 48891 52898958
Normal newborn 30.72 9.84 8 401209 7171 52940678
Neutropenic sepsis 30.68 9.84 39 401178 14610 52933239
Infusion related reaction 30.53 9.84 916 400301 155041 52792808
Fall 30.11 9.84 3107 398110 355333 52592516
Contusion 30.05 9.84 1066 400151 109666 52838183
Flushing 29.95 9.84 363 400854 70237 52877612
Painful respiration 29.94 9.84 64 401153 2626 52945223
Drug eruption 29.92 9.84 93 401124 25001 52922848
Anxiety 29.58 9.84 1194 400023 195510 52752339
Cardiac arrest 29.44 9.84 511 400706 93156 52854693
Eructation 29.29 9.84 127 401090 7728 52940121
Neutrophil count decreased 28.99 9.84 233 400984 48865 52898984
Duodenitis 28.83 9.84 74 401143 3425 52944424
Drug reaction with eosinophilia and systemic symptoms 28.77 9.84 375 400842 32425 52915424
Dyspepsia 28.76 9.84 776 400441 76824 52871025
Gamma-glutamyltransferase increased 28.75 9.84 382 400835 33173 52914676
Uterine perforation 28.61 9.84 10 401207 7409 52940440
Device dislocation 28.46 9.84 87 401130 23510 52924339
Premature baby 28.41 9.84 67 401150 19734 52928115
Abnormal behaviour 28.28 9.84 78 401139 21788 52926061
Cellulitis 28.10 9.84 402 400815 75587 52872262
Abdominal pain lower 27.98 9.84 286 400931 23307 52924542
Acute abdomen 27.83 9.84 47 401170 1611 52946238
Hiatus hernia 27.82 9.84 247 400970 19373 52928476
Platelet count decreased 27.52 9.84 611 400606 107488 52840361
Pregnancy 27.52 9.84 132 401085 31309 52916540
Product storage error 27.45 9.84 35 401182 13095 52934754
Injection site rash 27.22 9.84 52 401165 16527 52931322
Glomerulonephropathy 26.92 9.84 14 401203 92 52947757
Injection site haemorrhage 26.81 9.84 81 401136 21970 52925879
Rheumatoid factor positive 26.45 9.84 191 401026 41007 52906842
Body temperature decreased 26.04 9.84 214 401003 16413 52931436
Hypochromic anaemia 25.88 9.84 49 401168 1840 52946009
Suicide attempt 25.86 9.84 296 400921 57872 52889977
Nephrogenic anaemia 25.83 9.84 50 401167 1909 52945940
Device use error 25.79 9.84 5 401212 5494 52942355
Abortion induced 25.74 9.84 26 401191 10800 52937049
Food allergy 25.56 9.84 126 401091 8092 52939757
Cholestasis 25.56 9.84 329 400888 28366 52919483
Drug withdrawal syndrome 25.50 9.84 116 401101 27906 52919943
Clostridium test positive 25.18 9.84 55 401162 2291 52945558
Cholecystitis chronic 25.09 9.84 150 401067 10368 52937481
Joint stiffness 24.87 9.84 130 401087 30153 52917696
Pancytopenia 24.82 9.84 876 400341 90052 52857797
Vision blurred 24.71 9.84 474 400743 85130 52862719
Dysuria 24.58 9.84 343 400874 30110 52917739
Hepatitis acute 24.46 9.84 132 401085 8784 52939065
Blood pressure systolic increased 24.40 9.84 386 400831 34791 52913058
Brain contusion 24.37 9.84 26 401191 565 52947284
Premature rupture of membranes 24.24 9.84 4 401213 4936 52942913
Oesophagitis 24.12 9.84 191 401026 14486 52933363
Urosepsis 24.01 9.84 210 401007 16400 52931449
Diabetic nephropathy 23.65 9.84 41 401176 1436 52946413
Breath sounds abnormal 23.60 9.84 126 401091 8351 52939498
Pulmonary embolism 23.45 9.84 1069 400148 113373 52834476
Febrile infection 23.34 9.84 38 401179 1263 52946586
Colitis erosive 23.31 9.84 12 401205 77 52947772
Drug ineffective for unapproved indication 23.17 9.84 79 401138 20641 52927208
Somnolence 23.14 9.84 1028 400189 166706 52781143
Temperature regulation disorder 23.13 9.84 77 401140 4130 52943719
Injection site urticaria 23 9.84 37 401180 12570 52935279
Hyperkalaemia 22.87 9.84 552 400665 53704 52894145
Dysphoria 22.81 9.84 6 401211 5343 52942506
Underdose 22.77 9.84 84 401133 21438 52926411
Nephritis allergic 22.43 9.84 15 401202 165 52947684
Internal haemorrhage 22.39 9.84 82 401135 4614 52943235
Pancreatic steatosis 22.35 9.84 34 401183 1065 52946784
Coagulation test abnormal 22.27 9.84 28 401189 730 52947119
Device breakage 22.27 9.84 28 401189 10539 52937310
Disseminated intravascular coagulation 22.18 9.84 75 401142 19644 52928205
Panniculitis 21.95 9.84 16 401201 7798 52940051
Dyspnoea exertional 21.82 9.84 555 400662 54445 52893404
Hypertensive crisis 21.81 9.84 185 401032 14321 52933528
Colitis ulcerative 21.60 9.84 248 400969 20813 52927036
Synovial fluid analysis 21.59 9.84 43 401174 1677 52946172
Urinary tract infection enterococcal 21.59 9.84 55 401162 2534 52945315
Rapid eye movement sleep behaviour disorder 21.55 9.84 15 401202 177 52947672
Enthesopathy 21.54 9.84 11 401206 6500 52941349
Drug-induced liver injury 21.51 9.84 324 400893 28909 52918940
Hepatitis cholestatic 21.48 9.84 108 401109 6991 52940858
Syncope 21.42 9.84 1039 400178 110954 52836895
Peripheral arterial occlusive disease 21.41 9.84 72 401145 3882 52943967
Substance abuse 21.26 9.84 4 401213 4490 52943359
Myelosuppression 21.26 9.84 40 401177 12788 52935061
Haematotoxicity 21.13 9.84 17 401200 7880 52939969
Total lung capacity decreased 20.91 9.84 38 401179 1382 52946467
Pain in jaw 20.91 9.84 200 401017 40469 52907380
Urinary tract obstruction 20.90 9.84 45 401172 1856 52945993
Trimethylaminuria 20.86 9.84 14 401203 155 52947694
Treatment noncompliance 20.80 9.84 154 401063 32881 52914968
Thrombocytopenia 20.77 9.84 1258 399959 137469 52810380
Fracture 20.69 9.84 217 401000 17802 52930047
Hyperkinesia 20.65 9.84 47 401170 2013 52945836
Sopor 20.61 9.84 246 400971 20838 52927011
Subileus 20.55 9.84 62 401155 3154 52944695
Cardiac failure 20.54 9.84 815 400402 85029 52862820
Bursitis 20.50 9.84 259 400958 22233 52925616
Balance disorder 20.32 9.84 408 400809 72799 52875050
Somatic symptom disorder 20.08 9.84 47 401170 2051 52945798
Oesophageal dilatation 20.07 9.84 19 401198 356 52947493
Gastric haemorrhage 20.03 9.84 96 401121 6095 52941754
Headache 20.00 9.84 3644 397573 533177 52414672
Mydriasis 19.96 9.84 34 401183 11292 52936557
Sleep disorder 19.94 9.84 582 400635 58288 52889561
Poisoning 19.76 9.84 47 401170 13803 52934046
Haematocrit decreased 19.61 9.84 392 400825 36939 52910910
Neuropathy vitamin B12 deficiency 19.49 9.84 5 401212 0 52947849
Intermenstrual bleeding 19.44 9.84 22 401195 8676 52939173
Hepatitis B 19.44 9.84 3 401214 3889 52943960
Pharyngeal dystonia 19.27 9.84 6 401211 6 52947843
Shock 19.19 9.84 99 401118 23040 52924809
Rectal haemorrhage 19.02 9.84 427 400790 41054 52906795
Heavy menstrual bleeding 18.92 9.84 67 401150 17309 52930540
Cachexia 18.88 9.84 83 401134 5081 52942768
Diarrhoea 18.83 9.84 5129 396088 620417 52327432
Gastric ulcer 18.77 9.84 263 400954 23106 52924743
Prothrombin time shortened 18.72 9.84 42 401175 1782 52946067
Clostridium difficile infection 18.57 9.84 304 400913 27589 52920260
Spontaneous haemorrhage 18.55 9.84 16 401201 264 52947585
Cerebral ischaemia 18.51 9.84 99 401118 6566 52941283
Chronic gastritis 18.41 9.84 51 401166 2471 52945378
Prerenal failure 18.33 9.84 39 401178 1595 52946254
Therapeutic drug monitoring analysis incorrectly performed 18.22 9.84 13 401204 160 52947689
Spinal pain 18.11 9.84 149 401068 11431 52936418
Hepatic cyst 18.04 9.84 80 401137 4916 52942933
Medication error 17.84 9.84 378 400839 35987 52911862
Monoparesis 17.83 9.84 38 401179 1556 52946293
Complication associated with device 17.83 9.84 62 401155 16103 52931746
Wheelchair user 17.78 9.84 7 401210 4819 52943030
Low birth weight baby 17.77 9.84 13 401204 6324 52941525
Amenorrhoea 17.47 9.84 27 401190 9322 52938527
Gastritis erosive 17.47 9.84 86 401131 5520 52942329
Abdominal wall wound 17.45 9.84 9 401208 58 52947791
Vaginal haemorrhage 17.44 9.84 124 401093 26717 52921132
Hypotension 17.43 9.84 2174 399043 251902 52695947
Maternal drugs affecting foetus 17.43 9.84 10 401207 5536 52942313
Paresis 17.42 9.84 47 401170 2242 52945607
Musculoskeletal disorder 17.42 9.84 70 401147 17429 52930420
Tachyarrhythmia 17.39 9.84 76 401141 4640 52943209
Mixed liver injury 17.36 9.84 67 401150 3866 52943983
Tetany 17.33 9.84 41 401176 1802 52946047
Tenosynovitis stenosans 17.18 9.84 47 401170 2261 52945588
Reactive gastropathy 17.13 9.84 19 401198 432 52947417
Neuroleptic malignant syndrome 17.04 9.84 41 401176 11992 52935857
Pseudomembranous colitis 17.01 9.84 59 401158 3232 52944617
Hepatitis 16.85 9.84 353 400864 33541 52914308
Folate deficiency 16.82 9.84 44 401173 2060 52945789
Biliary dyskinesia 16.55 9.84 52 401165 2705 52945144
Pathogen resistance 16.48 9.84 15 401202 6545 52941304
Solar urticaria 16.39 9.84 8 401209 45 52947804
Haemarthrosis 16.36 9.84 58 401159 3212 52944637
Carcinoid tumour of the stomach 16.34 9.84 12 401205 155 52947694
Deafness 16.29 9.84 70 401147 17106 52930743
Fear of injection 16.29 9.84 11 401206 5578 52942271
Renal cyst 16.12 9.84 125 401092 9420 52938429
Nephropathy 16.10 9.84 82 401135 5335 52942514
Complication of device insertion 16.04 9.84 13 401204 6004 52941845
Sensory level abnormal 16.02 9.84 12 401205 160 52947689
Hepatic vein dilatation 15.98 9.84 6 401211 15 52947834
Joint injury 15.92 9.84 99 401118 22001 52925848
Agitation 15.89 9.84 328 400889 58298 52889551
Jaundice 15.82 9.84 318 400899 29995 52917854
Infective pulmonary exacerbation of cystic fibrosis 15.81 9.84 38 401179 11118 52936731
Hepatocellular injury 15.79 9.84 315 400902 29671 52918178
Serotonin syndrome 15.73 9.84 125 401092 26281 52921568
Renal impairment 15.72 9.84 772 400445 82546 52865303
Neutrophil function disorder 15.71 9.84 6 401211 16 52947833
Pseudarthrosis 15.70 9.84 18 401199 425 52947424
Strangury 15.59 9.84 5 401212 6 52947843
Flatulence 15.59 9.84 328 400889 31189 52916660
Arterial stenosis 15.52 9.84 22 401195 646 52947203
Helicobacter infection 15.43 9.84 394 400823 38675 52909174
Arterial occlusive disease 15.41 9.84 77 401140 4972 52942877
Injection site discolouration 15.40 9.84 19 401198 7211 52940638
Incorrect dosage administered 15.35 9.84 39 401178 1794 52946055
Pharyngitis 15.29 9.84 82 401135 18898 52928951
Iron deficiency anaemia 15.29 9.84 210 401007 18370 52929479
Occupational asthma 15.25 9.84 11 401206 138 52947711
Adenovirus infection 15.23 9.84 3 401214 3259 52944590
Nausea 15.20 9.84 6104 395113 749987 52197862
Patent ductus arteriosus 15.12 9.84 6 401211 4112 52943737
Bradycardia 15.04 9.84 666 400551 70390 52877459
Device malfunction 14.99 9.84 65 401152 15843 52932006
Deep vein thrombosis 14.98 9.84 765 400452 82148 52865701
Lipoedema 14.95 9.84 13 401204 217 52947632
Depressed level of consciousness 14.91 9.84 304 400913 54124 52893725
Nasopharyngitis 14.86 9.84 1658 399559 190637 52757212
Clostridium colitis 14.78 9.84 40 401177 1912 52945937
Pancreatitis 14.76 9.84 453 400764 45689 52902160
Atelectasis 14.72 9.84 221 400996 19705 52928144
Drug interaction 14.69 9.84 1874 399343 217455 52730394
Pneumonia aspiration 14.68 9.84 176 401041 34125 52913724
Poisoning deliberate 14.59 9.84 27 401190 8686 52939163
Gastrointestinal inflammation 14.53 9.84 72 401145 4634 52943215
Retroperitoneal haematoma 14.44 9.84 51 401166 2819 52945030
Post procedural pulmonary embolism 14.29 9.84 14 401203 274 52947575
Condition aggravated 14.22 9.84 1988 399229 295146 52652703
Pleural effusion 14.15 9.84 808 400409 87771 52860078
Nightmare 14.13 9.84 77 401140 17674 52930175
Salpingo-oophorectomy unilateral 14.11 9.84 21 401196 645 52947204
Toothache 14.10 9.84 78 401139 17836 52930013
Musculoskeletal pain 14.03 9.84 696 400521 74504 52873345
Device deployment issue 14.02 9.84 5 401212 3659 52944190
Liver injury 14.02 9.84 239 400978 21864 52925985
Dermatitis allergic 14.01 9.84 160 401057 13408 52934441
Rash 14.00 9.84 3055 398162 443136 52504713
Food aversion 13.98 9.84 18 401199 481 52947368
Complication of device removal 13.93 9.84 7 401210 4175 52943674
Hypochloraemia 13.86 9.84 39 401178 1907 52945942
Osteomyelitis 13.85 9.84 116 401101 24119 52923730
Mood swings 13.84 9.84 76 401141 17410 52930439
Swelling face 13.73 9.84 326 400891 56842 52891007
Pulmonary renal syndrome 13.68 9.84 16 401201 386 52947463
Metabolic surgery 13.66 9.84 27 401190 1047 52946802
Lactic acidosis 13.64 9.84 372 400845 36881 52910968
Joint swelling 13.64 9.84 1988 399229 232650 52715199
Intraocular pressure increased 13.63 9.84 17 401200 6421 52941428
Megacolon 13.61 9.84 39 401178 1927 52945922
Flank pain 13.55 9.84 163 401054 13833 52934016
Metastases to lung 13.51 9.84 44 401173 11660 52936189
Waist circumference increased 13.48 9.84 23 401194 795 52947054
Diverticulum intestinal 13.46 9.84 90 401127 6467 52941382
Hepatic enzyme abnormal 13.46 9.84 74 401143 4960 52942889
Transaminases increased 13.44 9.84 309 400908 29823 52918026
Anuria 13.44 9.84 148 401069 12292 52935557
Lethargy 13.35 9.84 305 400912 53455 52894394
Epstein-Barr virus infection 13.32 9.84 22 401195 7396 52940453
Surgery 13.30 9.84 165 401052 31799 52916050
Acute graft versus host disease 13.26 9.84 8 401209 4309 52943540
Hyperplastic cholecystopathy 13.24 9.84 9 401208 102 52947747
Cushingoid 13.23 9.84 96 401121 7086 52940763
Tuberculosis 13.22 9.84 41 401176 11030 52936819
Rapid correction of hyponatraemia 13.13 9.84 10 401207 137 52947712
Injection site mass 13.09 9.84 70 401147 16144 52931705
Hypergastrinaemia 13.09 9.84 9 401208 104 52947745
Sacroiliitis 13.08 9.84 45 401172 2455 52945394
Gastrointestinal toxicity 13.06 9.84 10 401207 4752 52943097
Bicytopenia 12.95 9.84 40 401177 2061 52945788
Carotid arteriosclerosis 12.93 9.84 26 401191 1021 52946828
Blood pressure diastolic abnormal 12.87 9.84 111 401106 8634 52939215
Abnormal dreams 12.84 9.84 39 401178 10562 52937287
Red blood cell sedimentation rate increased 12.77 9.84 142 401075 27915 52919934
Presyncope 12.76 9.84 272 400945 25922 52921927
Synovitis 12.75 9.84 672 400545 107221 52840628
Cerebellar ataxia 12.75 9.84 24 401193 897 52946952
Lung opacity 12.72 9.84 38 401179 1923 52945926
Therapeutic reaction time decreased 12.70 9.84 30 401187 1317 52946532
Gastric polyps 12.62 9.84 45 401172 2499 52945350
Vertigo 12.62 9.84 529 400688 55552 52892297
Lung diffusion test abnormal 12.60 9.84 8 401209 80 52947769
Dysphagia 12.56 9.84 765 400452 83632 52864217
Neurotoxicity 12.54 9.84 66 401151 15283 52932566
Productive cough 12.51 9.84 534 400683 56195 52891654
Application site pain 12.51 9.84 8 401209 4175 52943674
Hypomania 12.46 9.84 11 401206 4871 52942978
Pulmonary tuberculosis 12.45 9.84 11 401206 4870 52942979
Product administered to patient of inappropriate age 12.45 9.84 3 401214 2833 52945016
Oedema peripheral 12.44 9.84 1467 399750 169320 52778529
Multiple sclerosis relapse 12.44 9.84 250 400967 44603 52903246
Renal haemangioma 12.40 9.84 6 401211 33 52947816
Intestinal haemorrhage 12.35 9.84 55 401162 3385 52944464
Type I hypersensitivity 12.34 9.84 46 401171 2611 52945238
Vitamin B12 decreased 12.31 9.84 51 401166 3041 52944808
Therapy partial responder 12.30 9.84 17 401200 6146 52941703
Skin disorder 12.30 9.84 124 401093 24834 52923015
Respiratory depression 12.26 9.84 52 401165 12754 52935095
Feeling jittery 12.26 9.84 142 401075 11941 52935908
Basal cell carcinoma 12.24 9.84 115 401102 23354 52924495
Ear infection 12.22 9.84 130 401087 25770 52922079
Product complaint 12.22 9.84 49 401168 12208 52935641
Eosinophils urine present 12.21 9.84 5 401212 17 52947832
Aortic valve stenosis 12.13 9.84 53 401164 3235 52944614
Smear cervix abnormal 12.12 9.84 3 401214 2783 52945066
Spigelian hernia 12.12 9.84 6 401211 35 52947814
Thrombosis 12.04 9.84 566 400651 60227 52887622
Haemoptysis 12.04 9.84 286 400931 27753 52920096
Status epilepticus 12.01 9.84 66 401151 15118 52932731
Blood iron abnormal 11.97 9.84 5 401212 3322 52944527
Inappropriate antidiuretic hormone secretion 11.90 9.84 168 401049 14783 52933066
Acquired diaphragmatic eventration 11.87 9.84 14 401203 341 52947508
Oesophageal candidiasis 11.85 9.84 76 401141 5384 52942465
Bacterial test 11.83 9.84 28 401189 1231 52946618
Enterochromaffin cell hyperplasia 11.83 9.84 7 401210 61 52947788
Skin test positive 11.82 9.84 21 401196 750 52947099
Juvenile idiopathic arthritis 11.78 9.84 10 401207 4514 52943335
Laboratory test abnormal 11.73 9.84 122 401095 24287 52923562
Myocardial infarction 11.71 9.84 619 400598 98735 52849114
Disorientation 11.70 9.84 383 400834 38976 52908873
Automatism epileptic 11.69 9.84 3 401214 0 52947849
Speech rehabilitation 11.69 9.84 3 401214 0 52947849
Low density lipoprotein 11.69 9.84 3 401214 0 52947849
Demyelination 11.62 9.84 18 401199 6209 52941640
Neck pain 11.61 9.84 353 400864 59663 52888186
Tooth disorder 11.56 9.84 128 401089 25184 52922665
Neutropenia 11.55 9.84 1035 400182 158150 52789699
Cholangitis acute 11.54 9.84 16 401201 460 52947389
Breast discomfort 11.54 9.84 16 401201 460 52947389
Akathisia 11.52 9.84 30 401187 8541 52939308
Rash pruritic 11.51 9.84 287 400930 49723 52898126
Lymphoproliferative disorder 11.47 9.84 4 401213 2968 52944881
Squamous cell carcinoma of the oral cavity 11.43 9.84 13 401204 304 52947545
Wound treatment 11.41 9.84 11 401206 211 52947638
Cytomegalovirus infection 11.41 9.84 93 401124 19446 52928403
Hypertransaminasaemia 11.39 9.84 60 401157 3956 52943893
Coeliac disease 11.39 9.84 108 401109 8627 52939222
Myeloblast percentage decreased 11.34 9.84 6 401211 41 52947808
Wound infection fungal 11.31 9.84 9 401208 132 52947717
Rib deformity 11.30 9.84 10 401207 171 52947678
Abdominal distension 11.28 9.84 720 400497 79070 52868779
Enteritis 11.21 9.84 95 401122 7351 52940498
Nasal obstruction 11.20 9.84 25 401192 1057 52946792
Glomerulonephritis chronic 11.16 9.84 10 401207 174 52947675
Arterial haemorrhage 11.13 9.84 34 401183 1742 52946107
Natural killer cell count decreased 11.11 9.84 6 401211 43 52947806
Anal polyp 11.11 9.84 6 401211 43 52947806
Injection site induration 11.11 9.84 31 401186 8627 52939222
Epigastric discomfort 11.08 9.84 82 401135 6091 52941758
Vascular stent stenosis 11.07 9.84 17 401200 537 52947312
Duodenal polyp 10.98 9.84 8 401209 102 52947747
Pneumocystis jirovecii pneumonia 10.97 9.84 75 401142 16303 52931546
Iron deficiency 10.92 9.84 83 401134 6217 52941632
Gait deviation 10.86 9.84 7 401210 72 52947777
Blood creatinine increased 10.80 9.84 741 400476 81921 52865928
Spontaneous haematoma 10.77 9.84 21 401196 806 52947043
Hyperchlorhydria 10.77 9.84 32 401185 1614 52946235
Hypophysitis 10.76 9.84 32 401185 1615 52946234
Cytomegalovirus viraemia 10.75 9.84 13 401204 4978 52942871
Skin necrosis 10.71 9.84 42 401175 10530 52937319
Incorrect dose administered 10.68 9.84 297 400920 50748 52897101
Administration site discomfort 10.66 9.84 8 401209 107 52947742
Genital herpes simplex 10.62 9.84 10 401207 186 52947663
Norovirus infection 10.55 9.84 7 401210 76 52947773
Femoral hernia incarcerated 10.50 9.84 22 401195 890 52946959
Autoimmune nephritis 10.48 9.84 13 401204 334 52947515
White blood cell count abnormal 10.47 9.84 15 401202 5343 52942506
Adrenocortical insufficiency acute 10.46 9.84 30 401187 1483 52946366
Sexual dysfunction 10.45 9.84 6 401211 3320 52944529
Migraine 10.44 9.84 496 400721 79921 52867928
Metastases to bone 10.39 9.84 94 401123 19234 52928615
Tricuspid valve incompetence 10.38 9.84 159 401058 14237 52933612
Duodenal ulcer perforation 10.36 9.84 342 400875 34841 52913008
Injection site irritation 10.34 9.84 11 401206 4461 52943388
Ureteric stenosis 10.31 9.84 18 401199 634 52947215
Conjunctivitis 10.30 9.84 183 401034 16874 52930975
Incorrect product administration duration 10.26 9.84 43 401174 10581 52937268
C-reactive protein increased 10.22 9.84 616 400601 67270 52880579
Neurofibrosarcoma 10.22 9.84 9 401208 153 52947696
Faecal calprotectin increased 10.21 9.84 37 401180 2071 52945778
Anal haemorrhage 10.19 9.84 32 401185 1664 52946185
Premature labour 10.19 9.84 53 401164 12309 52935540
Grunting 10.17 9.84 11 401206 243 52947606
Microgenia 10.14 9.84 4 401213 12 52947837
Lung adenocarcinoma stage III 10.14 9.84 4 401213 12 52947837
Amnesia 10.13 9.84 261 400956 45027 52902822
Hepatic steatosis 10.13 9.84 264 400953 25995 52921854
Unevaluable event 10.10 9.84 289 400928 49209 52898640
White matter lesion 10.09 9.84 31 401186 1593 52946256
Cholecystitis 10.09 9.84 166 401051 15080 52932769
Maternal exposure before pregnancy 10.08 9.84 17 401200 5669 52942180
Psychomotor retardation 10.08 9.84 54 401163 3584 52944265
Tongue disorder 10.06 9.84 34 401183 8907 52938942
Rhabdomyolysis 10.04 9.84 415 400802 43508 52904341
Neurosensory hypoacusis 10.02 9.84 12 401205 297 52947552
Glomerular filtration rate decreased 9.98 9.84 143 401074 12624 52935225
Multiple sclerosis 9.91 9.84 144 401073 27009 52920840
Iliac artery occlusion 9.89 9.84 9 401208 160 52947689
Dyskinesia 9.89 9.84 174 401043 31659 52916190
Erysipelas 9.88 9.84 91 401126 7210 52940639
Lipase increased 9.87 9.84 111 401106 9267 52938582

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 837.80 10.83 2389 253165 112870 32145102
Toxicity to various agents 408.52 10.83 479 255075 177562 32080410
Drug ineffective 405.42 10.83 1599 253955 381878 31876094
Completed suicide 360.51 10.83 138 255416 92379 32165593
Chronic kidney disease 298.81 10.83 838 254716 39137 32218835
Hypomagnesaemia 246.50 10.83 491 255063 18314 32239658
Drug abuse 216.75 10.83 187 255367 80056 32177916
Product prescribing error 204.40 10.83 468 255086 19249 32238723
Haematochezia 187.73 10.83 706 254848 38502 32219470
Anaemia 175.06 10.83 2595 252959 221029 32036943
Death 146.37 10.83 2123 253431 380394 31877578
Systemic infection 138.43 10.83 124 255430 2059 32255913
Hypocalcaemia 128.15 10.83 436 255118 22618 32235354
End stage renal disease 127.86 10.83 228 255326 7809 32250163
Foetal exposure during pregnancy 121.86 10.83 88 255466 41213 32216759
Hepatic function abnormal 114.47 10.83 110 255444 44730 32213242
Product monitoring error 84.88 10.83 103 255451 2471 32255501
Acute kidney injury 84.45 10.83 2955 252599 290513 31967459
Renal injury 83.50 10.83 246 255308 11809 32246163
Cholestasis 82.20 10.83 425 255129 26608 32231364
Electrolyte imbalance 80.38 10.83 248 255306 12214 32245758
Intentional overdose 75.32 10.83 132 255422 41469 32216503
Dyspnoea 73.22 10.83 3511 252043 358534 31899438
Overdose 72.46 10.83 395 255159 86682 32171290
Melaena 71.32 10.83 492 255062 34173 32223799
Hypokalaemia 70.81 10.83 703 254851 54391 32203581
Syncope 69.90 10.83 1045 254509 89079 32168893
Off label use 68.75 10.83 1858 253696 304462 31953510
Intentional product misuse 65.62 10.83 114 255440 35937 32222035
Drug resistance 65.08 10.83 51 255503 22914 32235058
Haematemesis 63.36 10.83 403 255151 27232 32230740
Neuropathy peripheral 62.51 10.83 352 255202 76630 32181342
Blood loss anaemia 61.49 10.83 169 255385 7793 32250179
Abdominal pain lower 61.06 10.83 189 255365 9324 32248648
Treatment failure 60.78 10.83 136 255418 39027 32218945
Respiratory arrest 60.67 10.83 83 255471 28825 32229147
Abdominal pain upper 59.90 10.83 800 254754 66538 32191434
Abdominal pain 59.63 10.83 1568 253986 147961 32110011
Erysipelas 58.08 10.83 123 255431 4793 32253179
Cardiac arrest 57.09 10.83 486 255068 96290 32161682
Agranulocytosis 56.09 10.83 346 255208 23131 32234841
Gastrointestinal haemorrhage 54.90 10.83 974 254580 85908 32172064
Product dose omission issue 53.21 10.83 532 255022 102043 32155929
Irritability 51.52 10.83 71 255483 24583 32233389
Normocytic anaemia 50.80 10.83 73 255481 2074 32255898
Oedema peripheral 50.06 10.83 1212 254342 112879 32145093
Acute abdomen 49.11 10.83 69 255485 1919 32256053
Abnormal behaviour 47.88 10.83 84 255470 26382 32231590
Hepatitis cholestatic 47.86 10.83 158 255396 8067 32249905
Cardio-respiratory arrest 46.54 10.83 254 255300 55735 32202237
Febrile infection 45.88 10.83 71 255483 2158 32255814
Premature baby 45.44 10.83 47 255507 18471 32239501
Pallor 44.28 10.83 320 255234 22561 32235411
Type I hypersensitivity 44.04 10.83 50 255504 1115 32256857
Lower respiratory tract infection 42.62 10.83 105 255449 29138 32228834
Hypoparathyroidism secondary 42.60 10.83 21 255533 115 32257857
Labelled drug-drug interaction medication error 41.87 10.83 201 255353 12212 32245760
Drug withdrawal syndrome 41.54 10.83 59 255495 20172 32237800
Immune reconstitution inflammatory syndrome 41.13 10.83 12 255542 9547 32248425
Feeling abnormal 40.96 10.83 292 255262 60131 32197841
Gastrointestinal bacterial overgrowth 40.40 10.83 18 255536 75 32257897
Rectal haemorrhage 39.89 10.83 460 255094 36963 32221009
Infective exacerbation of chronic obstructive airways disease 39.56 10.83 60 255494 1791 32256181
Musculoskeletal pain 39.51 10.83 404 255150 31493 32226479
Insomnia 39.49 10.83 553 255001 99795 32158177
Gastrooesophageal reflux disease 39.30 10.83 432 255122 34306 32223666
Therapeutic drug monitoring analysis not performed 38.65 10.83 32 255522 475 32257497
Neutrophil count decreased 38.00 10.83 216 255338 46923 32211049
Subileus 37.72 10.83 81 255473 3187 32254785
Dyspnoea exertional 37.63 10.83 470 255084 38491 32219481
Leukopenia 37.60 10.83 673 254881 59449 32198523
Hypoparathyroidism 37.45 10.83 31 255523 460 32257512
Pathogen resistance 37.30 10.83 14 255540 9496 32248476
Platelet count decreased 37.17 10.83 655 254899 113936 32144036
Malaise 37.16 10.83 1084 254470 176054 32081918
Gastritis 37.04 10.83 296 255258 21531 32236441
C-reactive protein increased 36.57 10.83 556 254998 47546 32210426
Shock haemorrhagic 36.36 10.83 173 255381 10472 32247500
Therapeutic product effect incomplete 36.34 10.83 184 255370 41157 32216815
Atrial fibrillation 35.62 10.83 1184 254370 115520 32142452
Suicidal ideation 35.50 10.83 166 255388 37917 32220055
Drug hypersensitivity 35.47 10.83 387 255167 73013 32184959
Haematoma 35.07 10.83 332 255222 25352 32232620
Stomatitis 34.82 10.83 180 255374 40049 32217923
Asthenia 34.31 10.83 2221 253333 233723 32024249
Psychotic disorder 34.06 10.83 82 255472 22938 32235034
Mucosal haemorrhage 34.05 10.83 52 255502 1562 32256410
Cytomegalovirus infection 32.91 10.83 97 255457 25367 32232605
Visual acuity reduced 32.74 10.83 49 255505 16396 32241576
Agitation 32.59 10.83 290 255264 56946 32201026
Tachyarrhythmia 32.29 10.83 78 255476 3321 32254651
Hypertensive nephropathy 31.35 10.83 28 255526 463 32257509
Rash 31.28 10.83 1336 254218 207997 32049975
Product use in unapproved indication 31.04 10.83 490 255064 86714 32171258
Diastolic dysfunction 30.98 10.83 101 255453 5123 32252849
Seizure 30.76 10.83 603 254951 103251 32154721
Suicide attempt 30.42 10.83 176 255378 38068 32219904
Cardiac failure 29.76 10.83 937 254617 90736 32167236
Dyspnoea at rest 29.71 10.83 75 255479 3284 32254688
Serum ferritin decreased 29.51 10.83 29 255525 544 32257428
Exposure during pregnancy 29.46 10.83 18 255536 9211 32248761
Interstitial lung disease 28.95 10.83 349 255205 64652 32193320
Aggression 28.35 10.83 187 255367 39202 32218770
Hyperlipasaemia 28.34 10.83 28 255526 529 32257443
Sedation 28.20 10.83 65 255489 18461 32239511
Low birth weight baby 27.93 10.83 10 255544 6984 32250988
Liver disorder 27.75 10.83 141 255413 31513 32226459
Fracture 27.69 10.83 115 255439 6564 32251408
Wrong technique in product usage process 27.53 10.83 162 255392 34897 32223075
Injection site pain 27.45 10.83 150 255404 32908 32225064
Polyneuropathy 27.43 10.83 188 255366 13027 32244945
Synovitis 27.39 10.83 27 255527 10851 32247121
Troponin increased 27.29 10.83 152 255402 9790 32248182
Haematoma muscle 27.27 10.83 37 255517 995 32256977
Upper gastrointestinal haemorrhage 26.24 10.83 295 255259 23554 32234418
Drug ineffective for unapproved indication 26.22 10.83 43 255511 13869 32244103
Tetanus 26.21 10.83 12 255542 54 32257918
Angina pectoris 26.15 10.83 369 255185 31057 32226915
Vertigo 25.66 10.83 298 255256 23985 32233987
Acute graft versus host disease 25.63 10.83 9 255545 6361 32251611
Tricuspid valve incompetence 25.50 10.83 142 255412 9145 32248827
Cerebral infarction 25.36 10.83 121 255433 27493 32230479
Psoriasis 25.25 10.83 236 255318 45887 32212085
Intentional self-injury 25.24 10.83 44 255510 13856 32244116
Accidental overdose 24.75 10.83 74 255480 19265 32238707
Chronic graft versus host disease 24.54 10.83 3 255551 4437 32253535
Depression 24.54 10.83 578 254976 96482 32161490
Fear of disease 24.52 10.83 19 255535 255 32257717
Osteochondrosis 24.43 10.83 32 255522 831 32257141
Serotonin syndrome 23.86 10.83 74 255480 19043 32238929
Arrhythmia 23.80 10.83 400 255154 34903 32223069
Occupational dermatitis 23.74 10.83 12 255542 70 32257902
Lower gastrointestinal haemorrhage 23.67 10.83 134 255420 8683 32249289
Gastritis erosive 23.61 10.83 102 255452 5925 32252047
Nephrogenic anaemia 23.60 10.83 54 255500 2219 32255753
Dysplastic naevus 23.35 10.83 22 255532 391 32257581
Hyponatraemia 23.24 10.83 758 254796 73755 32184217
Rebound acid hypersecretion 23.21 10.83 13 255541 96 32257876
Vitamin B12 deficiency 22.84 10.83 64 255490 2985 32254987
Disease progression 22.59 10.83 515 255039 86347 32171625
Hydrocholecystis 22.49 10.83 18 255536 254 32257718
Colitis microscopic 22.43 10.83 48 255506 1884 32256088
Therapeutic response decreased 22.41 10.83 116 255438 25804 32232168
Urticaria 22.21 10.83 332 255222 59282 32198690
Bradyarrhythmia 22.17 10.83 51 255503 2103 32255869
Solar lentigo 22.12 10.83 22 255532 419 32257553
Abnormal dreams 21.86 10.83 21 255533 8543 32249429
Degenerative mitral valve disease 21.83 10.83 17 255537 230 32257742
Cardiac failure congestive 21.81 10.83 504 255050 84348 32173624
Hiatus hernia 21.80 10.83 118 255436 7518 32250454
Hypersensitivity 21.75 10.83 321 255233 57437 32200535
Thrombocytopenia 21.69 10.83 1397 254157 146902 32111070
Dizziness 21.67 10.83 1921 253633 207697 32050275
Cerebellar ischaemia 21.65 10.83 13 255541 111 32257861
Gamma-glutamyltransferase increased 21.57 10.83 351 255203 30431 32227541
Product use issue 21.40 10.83 289 255265 52488 32205484
Headache 21.07 10.83 1295 254259 194902 32063070
Rheumatoid arthritis 21.05 10.83 236 255318 44308 32213664
Peritoneal dialysis complication 21.04 10.83 4 255550 4264 32253708
Hepatocellular injury 20.95 10.83 297 255257 25021 32232951
Drug dependence 20.93 10.83 104 255450 23380 32234592
Anaphylactic reaction 20.83 10.83 145 255409 30027 32227945
Lactic acidosis 20.81 10.83 375 255179 33161 32224811
Accidental exposure to product 20.76 10.83 35 255519 11167 32246805
No adverse event 20.76 10.83 84 255470 19969 32238003
Tetany 20.75 10.83 28 255526 749 32257223
Post transplant lymphoproliferative disorder 20.63 10.83 10 255544 5824 32252148
Memory impairment 20.53 10.83 211 255343 40268 32217704
Injection site haemorrhage 20.52 10.83 22 255532 8506 32249466
Aortic valve stenosis 20.50 10.83 50 255504 2142 32255830
Anxiety 20.47 10.83 586 254968 95419 32162553
Injection site erythema 20.34 10.83 54 255500 14614 32243358
Microcytic anaemia 20.25 10.83 50 255504 2159 32255813
Nightmare 20.20 10.83 46 255508 13120 32244852
Nicotine dependence 20.18 10.83 23 255531 515 32257457
Body temperature decreased 20.14 10.83 152 255402 10862 32247110
Drug eruption 20.02 10.83 80 255474 19086 32238886
Multiple-drug resistance 19.80 10.83 3 255551 3772 32254200
Therapy partial responder 19.77 10.83 7 255547 4923 32253049
Drug reaction with eosinophilia and systemic symptoms 19.72 10.83 362 255192 32123 32225849
Mood swings 19.72 10.83 21 255533 8144 32249828
Withdrawal syndrome 19.71 10.83 41 255513 12081 32245891
Mitral valve incompetence 19.69 10.83 191 255363 14680 32243292
Adverse event 19.69 10.83 65 255489 16407 32241565
Photodermatosis 19.68 10.83 22 255532 482 32257490
Paresis 19.63 10.83 47 255507 1990 32255982
Chest injury 19.49 10.83 40 255514 1524 32256448
Foetal malformation 19.23 10.83 13 255541 139 32257833
Glomerular filtration rate decreased 19.21 10.83 169 255385 12642 32245330
Eosinophilia 19.16 10.83 289 255265 24669 32233303
Mean cell haemoglobin decreased 19.06 10.83 37 255517 1353 32256619
Serum ferritin abnormal 18.97 10.83 16 255538 244 32257728
Myocardial infarction 18.96 10.83 801 254753 124875 32133097
Iron deficiency anaemia 18.95 10.83 136 255418 9565 32248407
Peripheral arterial occlusive disease 18.93 10.83 92 255462 5617 32252355
Urogenital haemorrhage 18.91 10.83 22 255532 504 32257468
Disseminated intravascular coagulation 18.78 10.83 106 255448 23070 32234902
Poisoning 18.78 10.83 37 255517 11121 32246851
Anger 18.74 10.83 41 255513 11863 32246109
Gravitational oedema 18.53 10.83 24 255530 616 32257356
Autoimmune colitis 18.40 10.83 30 255524 954 32257018
Cachexia 18.40 10.83 107 255447 7002 32250970
Urinary hesitation 18.39 10.83 50 255504 2291 32255681
Hallucination 18.27 10.83 297 255257 52322 32205650
Helicobacter gastritis 18.16 10.83 30 255524 965 32257007
Gastrointestinal angiodysplasia 18.15 10.83 24 255530 629 32257343
Intestinal angioedema 18.12 10.83 13 255541 154 32257818
Flushing 18.03 10.83 157 255397 30970 32227002
Joint swelling 17.96 10.83 292 255262 51443 32206529
Gastrointestinal pain 17.88 10.83 57 255497 2857 32255115
Product storage error 17.86 10.83 18 255536 7160 32250812
Product quality issue 17.82 10.83 84 255470 19149 32238823
Lethargy 17.73 10.83 223 255331 41005 32216967
Fall 17.73 10.83 1781 253773 194420 32063552
Presyncope 17.69 10.83 211 255343 17090 32240882
Victim of child abuse 17.62 10.83 26 255528 757 32257215
Electrocardiogram QT prolonged 17.62 10.83 422 255132 39219 32218753
Altered state of consciousness 17.61 10.83 101 255453 21896 32236076
Bronchial wall thickening 17.48 10.83 29 255525 936 32257036
Drug screen false positive 17.47 10.83 26 255528 763 32257209
Miosis 17.26 10.83 26 255528 8678 32249294
Thrombotic microangiopathy 17.23 10.83 30 255524 9452 32248520
Right atrial hypertrophy 17.21 10.83 17 255537 321 32257651
Occult blood 17.20 10.83 20 255534 458 32257514
Neuroleptic malignant syndrome 17.05 10.83 75 255479 17420 32240552
Erectile dysfunction 17.03 10.83 89 255465 19750 32238222
Adjustment disorder 17.02 10.83 29 255525 957 32257015
Mean cell haemoglobin concentration 16.97 10.83 8 255546 39 32257933
Cold sweat 16.94 10.83 135 255419 9811 32248161
Hypertrophy 16.90 10.83 19 255535 419 32257553
Injection site swelling 16.81 10.83 31 255523 9553 32248419
Drug use disorder 16.61 10.83 4 255550 3617 32254355
Cytomegalovirus viraemia 16.59 10.83 17 255537 6710 32251262
Cardiac aneurysm 16.58 10.83 28 255526 917 32257055
Apparent death 16.57 10.83 4 255550 3611 32254361
Base excess decreased 16.52 10.83 14 255540 215 32257757
Perihepatic abscess 16.50 10.83 10 255544 87 32257885
Chronic kidney disease-mineral and bone disorder 16.44 10.83 18 255536 385 32257587
Tuberculosis 16.43 10.83 27 255527 8702 32249270
Dermatitis infected 16.24 10.83 11 255543 118 32257854
White blood cell count decreased 16.22 10.83 570 254984 90628 32167344
Mania 16.15 10.83 32 255522 9600 32248372
Jaundice 15.91 10.83 366 255188 33792 32224180
Peritonitis bacterial 15.86 10.83 48 255506 12448 32245524
Therapy non-responder 15.83 10.83 172 255382 32482 32225490
Osteonecrosis 15.75 10.83 72 255482 16550 32241422
Burns second degree 15.62 10.83 17 255537 361 32257611
Extrapyramidal disorder 15.59 10.83 45 255509 11850 32246122
N-terminal prohormone brain natriuretic peptide increased 15.56 10.83 43 255511 1989 32255983
Rash maculo-papular 15.55 10.83 308 255246 27714 32230258
Ventricular arrhythmia 15.53 10.83 80 255474 4999 32252973
Trisomy 18 15.50 10.83 14 255540 235 32257737
Duodenogastric reflux 15.42 10.83 4 255550 0 32257972
Treatment noncompliance 15.40 10.83 138 255416 27064 32230908
Sexual dysfunction 15.39 10.83 16 255538 6273 32251699
Acute graft versus host disease in skin 15.36 10.83 10 255544 4947 32253025
Pericardial disease 15.15 10.83 16 255538 328 32257644
Small for dates baby 15.08 10.83 4 255550 3389 32254583
Benign gastrointestinal neoplasm 15.08 10.83 11 255543 134 32257838
Blood iron decreased 15.02 10.83 75 255479 4629 32253343
Bronchopulmonary aspergillosis 15.02 10.83 56 255498 13631 32244341
Injection site bruising 14.90 10.83 24 255530 7796 32250176
Hospitalisation 14.89 10.83 283 255271 48688 32209284
Peripheral venous disease 14.88 10.83 49 255505 2498 32255474
Subacute cutaneous lupus erythematosus 14.86 10.83 24 255530 757 32257215
Bronchial obstruction 14.81 10.83 38 255516 1681 32256291
Injection site phlebitis 14.71 10.83 7 255547 35 32257937
Blood pressure fluctuation 14.63 10.83 231 255323 19904 32238068
Device issue 14.61 10.83 30 255524 8882 32249090
Uveitis 14.60 10.83 17 255537 6333 32251639
Upper motor neurone lesion 14.55 10.83 10 255544 110 32257862
Procalcitonin abnormal 14.55 10.83 10 255544 110 32257862
Dependence on oxygen therapy 14.45 10.83 12 255542 179 32257793
Thrombophlebitis 14.43 10.83 55 255499 3017 32254955
Flatulence 14.42 10.83 223 255331 19132 32238840
Hyperreflexia 14.42 10.83 3 255551 3001 32254971
Pulpitis dental 14.20 10.83 17 255537 402 32257570
Renal cyst 14.12 10.83 117 255437 8602 32249370
Pulmonary valve disease 14.02 10.83 14 255540 268 32257704
Neoplasm malignant 13.92 10.83 89 255465 18796 32239176
Cardiotoxicity 13.91 10.83 11 255543 4921 32253051
Mastitis 13.91 10.83 12 255542 189 32257783
Diverticulum intestinal 13.89 10.83 59 255495 3401 32254571
Procalcitonin increased 13.87 10.83 37 255517 1676 32256296
Weight decreased 13.86 10.83 1489 254065 163329 32094643
Tendonitis 13.82 10.83 30 255524 8705 32249267
Pulmonary embolism 13.69 10.83 796 254758 82863 32175109
Therapeutic product effect decreased 13.62 10.83 167 255387 30850 32227122
Drug abuser 13.58 10.83 8 255546 4176 32253796
Urinary straining 13.54 10.83 5 255549 11 32257961
Respiratory tract haemorrhage 13.53 10.83 27 255527 1008 32256964
Device leakage 13.51 10.83 10 255544 4626 32253346
Thrombocytosis 13.40 10.83 61 255493 3624 32254348
Faeces pale 13.38 10.83 34 255520 1495 32256477
Graft versus host disease 13.36 10.83 42 255512 10764 32247208
Leptospirosis 13.28 10.83 6 255548 26 32257946
Puncture site haematoma 13.19 10.83 11 255543 165 32257807
Activated partial thromboplastin time shortened 13.18 10.83 18 255536 487 32257485
Alanine aminotransferase increased 13.17 10.83 494 255060 77985 32179987
Exercise tolerance decreased 13.16 10.83 71 255483 4517 32253455
Myelocyte count increased 13.11 10.83 16 255538 386 32257586
Polypectomy 13.09 10.83 19 255535 545 32257427
Arteriosclerotic gangrene 13.07 10.83 8 255546 71 32257901
Fluid intake reduced 13.06 10.83 57 255497 3325 32254647
Lichenoid keratosis 13.03 10.83 45 255509 2351 32255621
Cellulitis 13.00 10.83 298 255256 49932 32208040
Hypertransaminasaemia 12.94 10.83 66 255488 4108 32253864
Tobacco abuse 12.92 10.83 16 255538 392 32257580
Confabulation 12.92 10.83 10 255544 134 32257838
Taste disorder 12.91 10.83 72 255482 4639 32253333
Gastrooesophageal sphincter insufficiency 12.89 10.83 8 255546 73 32257899
Dyskinesia 12.82 10.83 121 255433 23482 32234490
Jejunostomy 12.77 10.83 6 255548 29 32257943
Underdose 12.75 10.83 56 255498 13013 32244959
Abnormal faeces 12.74 10.83 53 255501 3027 32254945
Benign prostatic hyperplasia 12.73 10.83 151 255403 12213 32245759
Haemophagocytic lymphohistiocytosis 12.69 10.83 46 255508 11289 32246683
Occupational exposure to air contaminants 12.66 10.83 9 255545 105 32257867
Hypovolaemic shock 12.66 10.83 95 255459 6777 32251195
Paranasal sinus discomfort 12.57 10.83 22 255532 742 32257230
COVID-19 pneumonia 12.55 10.83 114 255440 8606 32249366
Hyperkinesia 12.54 10.83 43 255511 2239 32255733
Rhythm idioventricular 12.51 10.83 14 255540 307 32257665
Alveolar lung disease 12.49 10.83 16 255538 406 32257566
Sinusitis 12.47 10.83 207 255347 36353 32221619
Jugular vein distension 12.43 10.83 19 255535 571 32257401
Nuchal rigidity 12.39 10.83 17 255537 462 32257510
Incorrect dose administered 12.39 10.83 197 255357 34831 32223141
Granulomatous dermatitis 12.33 10.83 13 255541 266 32257706
Saliva altered 12.31 10.83 11 255543 182 32257790
Lymph node calcification 12.30 10.83 12 255542 223 32257749
Pneumonia cytomegaloviral 12.30 10.83 4 255550 2968 32255004
Wound haemorrhage 12.30 10.83 39 255515 1949 32256023
Chondrocalcinosis pyrophosphate 12.26 10.83 24 255530 883 32257089
Xyphoid retraction 12.26 10.83 11 255543 183 32257789
Road traffic accident 12.26 10.83 83 255471 17298 32240674
Painful respiration 12.20 10.83 30 255524 1292 32256680
Mood altered 12.18 10.83 33 255521 8871 32249101
Syringe issue 12.18 10.83 7 255547 3704 32254268
Pancreatic duct stenosis 12.16 10.83 11 255543 185 32257787
Congenital hiatus hernia 12.14 10.83 13 255541 271 32257701
Erythropenia 12.13 10.83 12 255542 227 32257745
Hepatorenal syndrome 12.13 10.83 47 255507 2598 32255374
Prolonged expiration 12.12 10.83 11 255543 186 32257786
Phlebitis infective 12.10 10.83 10 255544 148 32257824
Mucormycosis 12.10 10.83 16 255538 5638 32252334
Hemiparesis 12.09 10.83 181 255373 15426 32242546
Status epilepticus 11.99 10.83 51 255503 11955 32246017
Disorganised speech 11.99 10.83 21 255533 709 32257263
Myalgia 11.98 10.83 519 255035 80711 32177261
Faecal calprotectin increased 11.94 10.83 31 255523 1381 32256591
Medication error 11.94 10.83 246 255308 22289 32235683
Device dependence 11.87 10.83 6 255548 35 32257937
Pulmonary tuberculosis 11.86 10.83 13 255541 4976 32252996
Pneumonia aspiration 11.86 10.83 240 255314 40916 32217056
Gastrointestinal motility disorder 11.84 10.83 43 255511 2304 32255668
Bronchial secretion retention 11.82 10.83 26 255528 1040 32256932
Haemorrhagic disorder 11.82 10.83 19 255535 597 32257375
Haematotoxicity 11.81 10.83 22 255532 6754 32251218
Blood triglycerides increased 11.77 10.83 67 255487 14552 32243420
Vision blurred 11.76 10.83 261 255293 43925 32214047
Eosinophilic pneumonia 11.73 10.83 52 255502 3054 32254918
Retinitis viral 11.72 10.83 8 255546 87 32257885
Urosepsis 11.72 10.83 144 255410 11746 32246226
Post procedural haemorrhage 11.68 10.83 108 255446 8192 32249780
Epileptic encephalopathy 11.67 10.83 9 255545 120 32257852
Drug intolerance 11.64 10.83 303 255251 49932 32208040
Cytomegalovirus infection reactivation 11.63 10.83 6 255548 3373 32254599
Substance abuse 11.59 10.83 24 255530 7083 32250889
Splenic thrombosis 11.58 10.83 5 255549 19 32257953
Spinal cord herniation 11.56 10.83 3 255551 0 32257972
Blood alcohol abnormal 11.56 10.83 3 255551 0 32257972
Bladder diverticulitis 11.56 10.83 3 255551 0 32257972
Hypertensive crisis 11.55 10.83 113 255441 8704 32249268
Epstein-Barr virus infection 11.51 10.83 24 255530 7066 32250906
Pulmonary vascular disorder 11.50 10.83 19 255535 611 32257361
Adenovirus infection 11.47 10.83 12 255542 4692 32253280
Leptotrichia infection 11.42 10.83 8 255546 91 32257881
Strongyloidiasis 11.42 10.83 3 255551 2558 32255414
Clostridium difficile infection 11.40 10.83 200 255354 17596 32240376
Scan abnormal 11.38 10.83 5 255549 20 32257952
Renal haemangioma 11.38 10.83 5 255549 20 32257952
Degenerative aortic valve disease 11.38 10.83 5 255549 20 32257952
Seroma 11.37 10.83 19 255535 617 32257355
Prothrombin time prolonged 11.34 10.83 122 255432 9633 32248339
Acute coronary syndrome 11.31 10.83 163 255391 13778 32244194
Muscular weakness 11.30 10.83 428 255126 67501 32190471
Ventricular enlargement 11.28 10.83 16 255538 449 32257523
Organic brain syndrome 11.25 10.83 12 255542 249 32257723
Oesophageal infection 11.25 10.83 12 255542 249 32257723
Atrial septal defect 11.22 10.83 24 255530 7001 32250971
Peripheral paralysis 11.22 10.83 6 255548 40 32257932
Blindness 11.20 10.83 59 255495 13067 32244905
Chronic actinic dermatitis 11.19 10.83 5 255549 21 32257951
Anaemia of malignant disease 11.18 10.83 15 255539 399 32257573
Pyelitis 11.14 10.83 8 255546 95 32257877
Pulmonary sepsis 11.11 10.83 40 255514 2134 32255838
Autoimmune encephalopathy 11.10 10.83 6 255548 41 32257931
Bladder tamponade 11.07 10.83 17 255537 513 32257459
Walking aid user 11.06 10.83 32 255522 1520 32256452
Arteriovenous fistula 11.01 10.83 20 255534 695 32257277
Blood pressure increased 10.95 10.83 744 254810 78610 32179362
Hallucination, auditory 10.94 10.83 43 255511 10307 32247665
Nocardiosis 10.93 10.83 8 255546 3723 32254249
Shock 10.91 10.83 129 255425 23985 32233987
Intestinal haemorrhage 10.88 10.83 54 255500 3325 32254647
Unevaluable event 10.86 10.83 192 255362 33394 32224578
Systolic dysfunction 10.85 10.83 41 255513 2239 32255733
Tumour pain 10.85 10.83 25 255529 1032 32256940

Pharmacologic Action:

SourceCodeDescription
ATC A02BC02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Proton pump inhibitors
ATC A02BD04 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
ATC A02BD11 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
FDA MoA N0000000147 Proton Pump Inhibitors
FDA EPC N0000175525 Proton Pump Inhibitor
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054328 Proton Pump Inhibitors
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:49200 proton pump inhibitors
CHEBI has role CHEBI:49201 anti-ulcer agents
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Erosive esophagitis indication 40719004
Zollinger-Ellison syndrome indication 53132006 DOID:0050782
Multiple endocrine adenomas indication 60549007
Gastroesophageal reflux disease indication 235595009 DOID:8534
Maintenance of Healing Erosive Esophagitis indication
Gastric Hypersecretory Conditions indication
Upper gastrointestinal hemorrhage off-label use 37372002
Duodenal ulcer disease off-label use 51868009 DOID:1724
Gastric ulcer off-label use 397825006 DOID:10808
Pathological Gastric Hypersecretory Condition off-label use
Duodenal Ulcer due to H. Pylori off-label use
Prevention of NSAID-Induced Gastric Ulcer off-label use
Osteoporosis contraindication 64859006 DOID:11476
Pernicious anemia contraindication 84027009 DOID:13381
Fracture of bone contraindication 125605004
Hypomagnesemia contraindication 190855004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.42 acidic
pKa2 3.58 Basic
pKa3 2.32 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 40MG BASE PROTONIX WYETH PHARMS N022020 Nov. 14, 2007 RX FOR SUSPENSION, DELAYED RELEASE ORAL 7550153 Sept. 30, 2024 EROSIVE ESOPHAGITIS, HYPERSECRETORY CONDITIONS INCLUDING ZOLLINGER-ELLISON SYNDROME, MAINTENANCE OF HEALING OF EROSIVE ESOPHAGITIS AND REDUCTION OF SYMPTOMS IN PATIENTS WITH GERD
EQ 40MG BASE PROTONIX WYETH PHARMS N022020 Nov. 14, 2007 RX FOR SUSPENSION, DELAYED RELEASE ORAL 7553498 Sept. 30, 2024 EROSIVE ESOPHAGITIS, HYPERSECRETORY CONDITIONS INCLUDING ZOLLINGER-ELLISON SYNDROME, MAINTENANCE OF HEALING OF EROSIVE ESOPHAGITIS AND REDUCTION OF SYMPTOMS IN PATIENTS WITH GERD
EQ 40MG BASE PROTONIX WYETH PHARMS N022020 Nov. 14, 2007 RX FOR SUSPENSION, DELAYED RELEASE ORAL 7838027 Sept. 30, 2024 EROSIVE ESOPHAGITIS, HYPERSECRETORY CONDITIONS INCLUDING ZOLLINGER-ELLISON SYNDROME, MAINTENANCE OF HEALING OF EROSIVE ESOPHAGITIS AND REDUCTION OF SYMPTOMS IN PATIENTS WITH GERD

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium-transporting ATPase Transporter INHIBITOR CHEMBL CHEMBL
Fatty acid synthase Enzyme Ki 5.39 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 5.82 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 5.55 CHEMBL
Multidrug and toxin extrusion protein 2 Transporter IC50 4.36 CHEMBL
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Enzyme IC50 4.20 CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter WOMBAT-PK
Indoleamine 2,3-dioxygenase 2 Enzyme IC50 4.90 CHEMBL
Potassium-transporting ATPase Enzyme IC50 6 SCIENTIFIC LITERATURE

External reference:

IDSource
4021208 VUID
N0000148654 NUI
D02593 KEGG_DRUG
164579-32-2 SECONDARY_CAS_RN
4021208 VANDF
4021209 VANDF
C0081876 UMLSCUI
CHEBI:7915 CHEBI
CHEMBL1502 ChEMBL_ID
CHEMBL3989559 ChEMBL_ID
CHEMBL1200408 ChEMBL_ID
DB00213 DRUGBANK_ID
D000077402 MESH_DESCRIPTOR_UI
4679 PUBCHEM_CID
7260 IUPHAR_LIGAND_ID
6548 INN_ID
D8TST4O562 UNII
236632 RXNORM
130104 MMSL
8654 MMSL
d04514 MMSL
006006 NDDF
006493 NDDF
009120 NDDF
116510001 SNOMEDCT_US
317317009 SNOMEDCT_US
395821003 SNOMEDCT_US
432408008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Protonix Delayed-Release HUMAN PRESCRIPTION DRUG LABEL 1 0008-0841 TABLET, DELAYED RELEASE 40 mg ORAL NDA 30 sections
Protonix Delayed-Release HUMAN PRESCRIPTION DRUG LABEL 1 0008-0843 TABLET, DELAYED RELEASE 20 mg ORAL NDA 30 sections
Protonix Delayed-Release HUMAN PRESCRIPTION DRUG LABEL 1 0008-0844 GRANULE, DELAYED RELEASE 40 mg ORAL NDA 30 sections
Protonix I.V. HUMAN PRESCRIPTION DRUG LABEL 1 0008-0923 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 28 sections
Protonix I.V. HUMAN PRESCRIPTION DRUG LABEL 1 0008-2001 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 27 sections
Protonix I.V. HUMAN PRESCRIPTION DRUG LABEL 1 0008-4001 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9284 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 40 mg INTRAVENOUS NDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9300 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 40 mg INTRAVENOUS NDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-6688 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-6689 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8113 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8308 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 29 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0781-3232 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS ANDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0904-6474 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 27 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0904-6870 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 27 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-096 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-429 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 27 sections
PANTOPRAZOLE SODIUMDELAYED RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 16590-635 TABLET, DELAYED RELEASE 20 mg ORAL NDA 30 sections
PROTONIXDELAYED-RELEASE HUMAN PRESCRIPTION DRUG LABEL 1 16590-939 TABLET, DELAYED RELEASE 20 mg ORAL NDA 30 sections
Protonix HUMAN PRESCRIPTION DRUG LABEL 1 21695-108 TABLET, DELAYED RELEASE 40 mg ORAL NDA 27 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-771 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 28 sections
PANTOPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 31722-712 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 26 sections
PANTOPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 31722-713 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-629 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 29 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33358-536 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 28 sections
Pantoprazole Sodium Human Prescription Drug Label 1 35573-428 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 27 sections
PANTOPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 42254-124 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 27 sections
PANTOPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 42291-765 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 26 sections
PANTOPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 42708-104 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 29 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 43063-618 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 27 sections