Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, 6-aminopenicillanic acid derivatives | 192 | 26787-78-0 |
Dose | Unit | Route |
---|---|---|
1.50 | g | O |
3 | g | P |
1.50 | g | O |
3 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 3.50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 86 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 68.42 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 93 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.25 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.85 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.10 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 9, 1974 | FDA | APOTHECON |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 851.72 | 9.77 | 1508 | 82782 | 249502 | 50271332 |
Rash maculo-papular | 546.80 | 9.77 | 410 | 83880 | 26231 | 50494603 |
Pruritus | 415.30 | 9.77 | 1222 | 83068 | 282346 | 50238488 |
Urticaria | 411.85 | 9.77 | 758 | 83532 | 128803 | 50392031 |
Angioedema | 408.04 | 9.77 | 402 | 83888 | 37274 | 50483560 |
Drug reaction with eosinophilia and systemic symptoms | 392.06 | 9.77 | 347 | 83943 | 28077 | 50492757 |
Erythema | 326.74 | 9.77 | 740 | 83550 | 145674 | 50375160 |
Anaphylactic shock | 302.01 | 9.77 | 258 | 84032 | 19897 | 50500937 |
Cross sensitivity reaction | 300.99 | 9.77 | 116 | 84174 | 1853 | 50518981 |
Lip swelling | 253.11 | 9.77 | 256 | 84034 | 24480 | 50496354 |
Acute generalised exanthematous pustulosis | 249.33 | 9.77 | 166 | 84124 | 8772 | 50512062 |
Abortion spontaneous | 247.46 | 9.77 | 326 | 83964 | 41446 | 50479388 |
Type IV hypersensitivity reaction | 229.17 | 9.77 | 102 | 84188 | 2380 | 50518454 |
Drug ineffective | 223.13 | 9.77 | 667 | 83623 | 818666 | 49702168 |
Toxic skin eruption | 212.79 | 9.77 | 165 | 84125 | 11086 | 50509748 |
Lip oedema | 210.59 | 9.77 | 104 | 84186 | 3089 | 50517745 |
Rash | 204.79 | 9.77 | 1336 | 82954 | 436135 | 50084699 |
Anaphylactic reaction | 190.31 | 9.77 | 331 | 83959 | 53724 | 50467110 |
Face oedema | 181.35 | 9.77 | 184 | 84106 | 17655 | 50503179 |
Pemphigus | 180.73 | 9.77 | 4 | 84286 | 120162 | 50400672 |
Synovitis | 166.28 | 9.77 | 10 | 84280 | 123855 | 50396979 |
Systemic lupus erythematosus | 151.33 | 9.77 | 26 | 84264 | 140596 | 50380238 |
Type I hypersensitivity | 149.36 | 9.77 | 75 | 84215 | 2310 | 50518524 |
Swelling face | 146.19 | 9.77 | 291 | 83999 | 52304 | 50468530 |
Swollen tongue | 144.73 | 9.77 | 207 | 84083 | 28423 | 50492411 |
Hepatocellular injury | 140.66 | 9.77 | 194 | 84096 | 25753 | 50495081 |
Arthropathy | 130.28 | 9.77 | 50 | 84240 | 157856 | 50362978 |
Stevens-Johnson syndrome | 129.14 | 9.77 | 170 | 84120 | 21582 | 50499252 |
White blood cell count abnormal | 128.03 | 9.77 | 91 | 84199 | 5349 | 50515485 |
Macular degeneration | 127.63 | 9.77 | 138 | 84152 | 14250 | 50506584 |
Crystalluria | 125.57 | 9.77 | 40 | 84250 | 349 | 50520485 |
Tongue oedema | 123.53 | 9.77 | 78 | 84212 | 3761 | 50517073 |
Hand deformity | 118.34 | 9.77 | 14 | 84276 | 100185 | 50420649 |
Acute kidney injury | 117.12 | 9.77 | 714 | 83576 | 227344 | 50293490 |
Rash pruritic | 116.83 | 9.77 | 251 | 84039 | 47595 | 50473239 |
Cholecystitis chronic | 113.68 | 9.77 | 108 | 84182 | 9561 | 50511273 |
Alopecia | 112.47 | 9.77 | 146 | 84144 | 244901 | 50275933 |
Glossodynia | 110.68 | 9.77 | 28 | 84262 | 115541 | 50405293 |
Infusion related reaction | 106.91 | 9.77 | 76 | 84214 | 169481 | 50351353 |
Erythema multiforme | 106.24 | 9.77 | 101 | 84189 | 8949 | 50511885 |
Death | 104.58 | 9.77 | 243 | 84047 | 325136 | 50195698 |
Wound closure | 102.56 | 9.77 | 26 | 84264 | 86 | 50520748 |
Completed suicide | 100.38 | 9.77 | 47 | 84243 | 131842 | 50388992 |
Eosinophilia | 97.42 | 9.77 | 137 | 84153 | 18515 | 50502319 |
Therapeutic product effect decreased | 96.78 | 9.77 | 53 | 84237 | 135997 | 50384837 |
Pericarditis | 95.42 | 9.77 | 10 | 84280 | 78679 | 50442155 |
Rash erythematous | 94.63 | 9.77 | 191 | 84099 | 34661 | 50486173 |
Enterocolitis haemorrhagic | 91.87 | 9.77 | 45 | 84245 | 1312 | 50519522 |
Fatigue | 89.33 | 9.77 | 753 | 83537 | 706848 | 49813986 |
Osteotomy | 86.99 | 9.77 | 26 | 84264 | 179 | 50520655 |
Jaundice | 86.73 | 9.77 | 157 | 84133 | 26272 | 50494562 |
Rash macular | 85.36 | 9.77 | 131 | 84159 | 19146 | 50501688 |
Wound | 84.76 | 9.77 | 35 | 84255 | 105759 | 50415075 |
Off label use | 84.73 | 9.77 | 455 | 83835 | 473971 | 50046863 |
Tubulointerstitial nephritis | 81.34 | 9.77 | 113 | 84177 | 15098 | 50505736 |
Treatment failure | 81.23 | 9.77 | 66 | 84224 | 137571 | 50383263 |
Paraesthesia oral | 81.17 | 9.77 | 101 | 84189 | 12120 | 50508714 |
Fall | 76.61 | 9.77 | 293 | 83997 | 334639 | 50186195 |
Cholestasis | 74.74 | 9.77 | 144 | 84146 | 25257 | 50495577 |
Arthralgia | 74.33 | 9.77 | 428 | 83862 | 438274 | 50082560 |
Product use issue | 71.71 | 9.77 | 86 | 84204 | 149389 | 50371445 |
Abdominal discomfort | 71.16 | 9.77 | 177 | 84113 | 231464 | 50289370 |
Toxic epidermal necrolysis | 70.54 | 9.77 | 126 | 84164 | 20866 | 50499968 |
Contraindicated product administered | 70.09 | 9.77 | 87 | 84203 | 148871 | 50371963 |
Maternal exposure during pregnancy | 67.74 | 9.77 | 477 | 83813 | 159301 | 50361533 |
Meningitis aseptic | 65.97 | 9.77 | 55 | 84235 | 4097 | 50516737 |
Discomfort | 65.16 | 9.77 | 51 | 84239 | 108329 | 50412505 |
Duodenal ulcer perforation | 63.31 | 9.77 | 3 | 84287 | 45608 | 50475226 |
Rash morbilliform | 63.29 | 9.77 | 46 | 84244 | 2800 | 50518034 |
Hepatitis cholestatic | 60.17 | 9.77 | 62 | 84228 | 6055 | 50514779 |
Drug intolerance | 60.08 | 9.77 | 177 | 84113 | 218927 | 50301907 |
Joint swelling | 55.11 | 9.77 | 216 | 84074 | 245070 | 50275764 |
Eyelid oedema | 54.66 | 9.77 | 73 | 84217 | 9393 | 50511441 |
Dermatitis allergic | 54.30 | 9.77 | 85 | 84205 | 12635 | 50508199 |
Emotional distress | 54.16 | 9.77 | 136 | 84154 | 28527 | 50492307 |
Hallucinations, mixed | 52.41 | 9.77 | 48 | 84242 | 4055 | 50516779 |
Injury | 52.40 | 9.77 | 190 | 84100 | 48735 | 50472099 |
Hepatic enzyme increased | 51.31 | 9.77 | 94 | 84196 | 137286 | 50383548 |
Throat tightness | 50.44 | 9.77 | 109 | 84181 | 20738 | 50500096 |
Injection site pain | 49.99 | 9.77 | 67 | 84223 | 110957 | 50409877 |
Clostridium difficile infection | 49.43 | 9.77 | 122 | 84168 | 25317 | 50495517 |
Swelling | 48.29 | 9.77 | 172 | 84118 | 200700 | 50320134 |
Therapeutic product effect incomplete | 47.89 | 9.77 | 49 | 84241 | 91466 | 50429368 |
Periorbital oedema | 47.86 | 9.77 | 50 | 84240 | 4962 | 50515872 |
Laryngeal oedema | 47.52 | 9.77 | 50 | 84240 | 5003 | 50515831 |
Basilar artery occlusion | 46.89 | 9.77 | 14 | 84276 | 96 | 50520738 |
Tooth demineralisation | 46.01 | 9.77 | 9 | 84281 | 3 | 50520831 |
Drug eruption | 45.64 | 9.77 | 113 | 84177 | 23493 | 50497341 |
Skin candida | 45.33 | 9.77 | 28 | 84262 | 1298 | 50519536 |
Vascular purpura | 45.00 | 9.77 | 27 | 84263 | 1187 | 50519647 |
Dermatitis exfoliative generalised | 44.74 | 9.77 | 39 | 84251 | 3087 | 50517747 |
Muscle injury | 44.26 | 9.77 | 5 | 84285 | 37106 | 50483728 |
Injection site erythema | 44.10 | 9.77 | 36 | 84254 | 74900 | 50445934 |
Weight increased | 42.07 | 9.77 | 183 | 84107 | 201708 | 50319126 |
Diarrhoea | 41.51 | 9.77 | 1277 | 83013 | 587199 | 49933635 |
Loss of personal independence in daily activities | 40.80 | 9.77 | 34 | 84256 | 70016 | 50450818 |
Folliculitis | 40.55 | 9.77 | 8 | 84282 | 39217 | 50481617 |
Vomiting | 39.75 | 9.77 | 1026 | 83264 | 459732 | 50061102 |
Purpura | 39.24 | 9.77 | 64 | 84226 | 9847 | 50510987 |
Pseudomembranous colitis | 38.37 | 9.77 | 34 | 84256 | 2751 | 50518083 |
Impaired healing | 38.08 | 9.77 | 36 | 84254 | 69750 | 50451084 |
Documented hypersensitivity to administered product | 37.71 | 9.77 | 18 | 84272 | 495 | 50520339 |
Malaise | 37.53 | 9.77 | 775 | 83515 | 334757 | 50186077 |
Bronchospasm | 36.32 | 9.77 | 78 | 84212 | 14776 | 50506058 |
Agranulocytosis | 35.72 | 9.77 | 97 | 84193 | 21324 | 50499510 |
Premature baby | 35.69 | 9.77 | 88 | 84202 | 18249 | 50502585 |
Febrile neutropenia | 33.70 | 9.77 | 70 | 84220 | 97597 | 50423237 |
Knee arthroplasty | 33.69 | 9.77 | 9 | 84281 | 35837 | 50484997 |
Hyperleukocytosis | 33.26 | 9.77 | 16 | 84274 | 448 | 50520386 |
Mobility decreased | 33.26 | 9.77 | 51 | 84239 | 79897 | 50440937 |
Condition aggravated | 32.52 | 9.77 | 327 | 83963 | 296731 | 50224103 |
Drug abuse | 32.50 | 9.77 | 31 | 84259 | 59815 | 50461019 |
Flank pain | 32.22 | 9.77 | 69 | 84221 | 13046 | 50507788 |
Dental operation | 32.18 | 9.77 | 21 | 84269 | 1072 | 50519762 |
Tongue discolouration | 32.16 | 9.77 | 31 | 84259 | 2793 | 50518041 |
Thermal burn | 32.13 | 9.77 | 40 | 84250 | 4801 | 50516033 |
Hepatic ischaemia | 32.04 | 9.77 | 17 | 84273 | 588 | 50520246 |
Peritonsillar abscess | 31.91 | 9.77 | 16 | 84274 | 491 | 50520343 |
Chronic sinusitis | 31.88 | 9.77 | 45 | 84245 | 6100 | 50514734 |
Chronic kidney disease | 31.79 | 9.77 | 141 | 84149 | 39630 | 50481204 |
Eczema | 31.28 | 9.77 | 96 | 84194 | 22606 | 50498228 |
Salpingo-oophorectomy unilateral | 30.93 | 9.77 | 16 | 84274 | 525 | 50520309 |
Foetal exposure during pregnancy | 30.78 | 9.77 | 108 | 84182 | 27251 | 50493583 |
Drug interaction | 30.73 | 9.77 | 485 | 83805 | 199136 | 50321698 |
Palatal oedema | 30.70 | 9.77 | 15 | 84275 | 435 | 50520399 |
Somatic delusion | 30.25 | 9.77 | 16 | 84274 | 550 | 50520284 |
Moraxella test positive | 29.80 | 9.77 | 7 | 84283 | 15 | 50520819 |
Clostridium difficile colitis | 29.24 | 9.77 | 80 | 84210 | 17662 | 50503172 |
Wheezing | 29.09 | 9.77 | 190 | 84100 | 61857 | 50458977 |
Toxicity to various agents | 28.97 | 9.77 | 221 | 84069 | 212278 | 50308556 |
Abdominal pain | 28.16 | 9.77 | 551 | 83739 | 235677 | 50285157 |
Gallbladder disorder | 28.10 | 9.77 | 76 | 84214 | 16666 | 50504168 |
Device expulsion | 27.54 | 9.77 | 7 | 84283 | 28815 | 50492019 |
Intentional product use issue | 27.50 | 9.77 | 54 | 84236 | 76864 | 50443970 |
Chromaturia | 27.32 | 9.77 | 69 | 84221 | 14521 | 50506313 |
Injection site swelling | 27.26 | 9.77 | 18 | 84272 | 41755 | 50479079 |
Dermatitis exfoliative | 27.19 | 9.77 | 38 | 84252 | 5104 | 50515730 |
Acute hepatic failure | 27.15 | 9.77 | 72 | 84218 | 15605 | 50505229 |
Stomatitis | 26.93 | 9.77 | 83 | 84207 | 101261 | 50419573 |
Eye swelling | 26.66 | 9.77 | 84 | 84206 | 20060 | 50500774 |
Sinusitis fungal | 26.55 | 9.77 | 20 | 84270 | 1286 | 50519548 |
Irritable bowel syndrome | 26.39 | 9.77 | 28 | 84262 | 51413 | 50469421 |
Breast cancer | 25.99 | 9.77 | 20 | 84270 | 42870 | 50477964 |
Localised oedema | 25.78 | 9.77 | 36 | 84254 | 4831 | 50516003 |
Candida infection | 25.73 | 9.77 | 92 | 84198 | 23431 | 50497403 |
Muscle relaxant therapy | 25.59 | 9.77 | 10 | 84280 | 166 | 50520668 |
Helicobacter infection | 25.55 | 9.77 | 27 | 84263 | 49675 | 50471159 |
Oral discomfort | 25.50 | 9.77 | 47 | 84243 | 7970 | 50512864 |
Normal tension glaucoma | 25.48 | 9.77 | 7 | 84283 | 34 | 50520800 |
Hepatic cytolysis | 25.15 | 9.77 | 47 | 84243 | 8056 | 50512778 |
Rheumatoid arthritis | 25.15 | 9.77 | 216 | 84074 | 202334 | 50318500 |
Deafness | 25.11 | 9.77 | 70 | 84220 | 15621 | 50505213 |
Excessive eye blinking | 25.01 | 9.77 | 17 | 84273 | 929 | 50519905 |
Staphylococcal scalded skin syndrome | 24.90 | 9.77 | 9 | 84281 | 119 | 50520715 |
Tooth infection | 24.63 | 9.77 | 65 | 84225 | 14047 | 50506787 |
Ill-defined disorder | 24.57 | 9.77 | 33 | 84257 | 54621 | 50466213 |
Influenza B virus test positive | 24.54 | 9.77 | 11 | 84279 | 261 | 50520573 |
Tinnitus | 24.22 | 9.77 | 102 | 84188 | 28030 | 50492804 |
Biliary sepsis | 24.22 | 9.77 | 16 | 84274 | 834 | 50520000 |
Allergy to chemicals | 24.02 | 9.77 | 19 | 84271 | 1313 | 50519521 |
Dermatitis bullous | 24.02 | 9.77 | 43 | 84247 | 7130 | 50513704 |
Hip arthroplasty | 22.89 | 9.77 | 11 | 84279 | 30418 | 50490416 |
Skin test positive | 22.82 | 9.77 | 14 | 84276 | 641 | 50520193 |
Drug-induced liver injury | 22.75 | 9.77 | 100 | 84190 | 27995 | 50492839 |
Malignant neoplasm progression | 22.52 | 9.77 | 50 | 84240 | 68074 | 50452760 |
Crystal nephropathy | 22.40 | 9.77 | 15 | 84275 | 800 | 50520034 |
Arthritis | 22.35 | 9.77 | 72 | 84218 | 86649 | 50434185 |
Pain in extremity | 22.33 | 9.77 | 320 | 83970 | 272545 | 50248289 |
Injection site pruritus | 21.86 | 9.77 | 21 | 84269 | 40390 | 50480444 |
Lymphadenopathy | 21.86 | 9.77 | 112 | 84178 | 33387 | 50487447 |
Hepatitis | 21.82 | 9.77 | 107 | 84183 | 31346 | 50489488 |
Therapeutic response decreased | 21.76 | 9.77 | 28 | 84262 | 47203 | 50473631 |
Tongue coated | 21.53 | 9.77 | 17 | 84273 | 1172 | 50519662 |
Hepatorenal syndrome | 21.50 | 9.77 | 20 | 84270 | 1723 | 50519111 |
Psychotic symptom | 21.24 | 9.77 | 17 | 84273 | 1195 | 50519639 |
Foetal non-stress test abnormal | 21.22 | 9.77 | 6 | 84284 | 33 | 50520801 |
Pneumonia aspiration | 20.72 | 9.77 | 13 | 84277 | 30991 | 50489843 |
Hyperaemia | 20.56 | 9.77 | 21 | 84269 | 2029 | 50518805 |
Pharyngeal paraesthesia | 20.37 | 9.77 | 18 | 84272 | 1451 | 50519383 |
Pharyngeal oedema | 20.35 | 9.77 | 58 | 84232 | 13107 | 50507727 |
Visual snow syndrome | 20.35 | 9.77 | 5 | 84285 | 14 | 50520820 |
Sputum increased | 20.34 | 9.77 | 20 | 84270 | 1847 | 50518987 |
Interstitial lung disease | 20.18 | 9.77 | 36 | 84254 | 53140 | 50467694 |
Foetal heart rate decreased | 20.14 | 9.77 | 8 | 84282 | 139 | 50520695 |
Prothrombin time ratio decreased | 20.11 | 9.77 | 11 | 84279 | 405 | 50520429 |
Adverse event | 20.10 | 9.77 | 26 | 84264 | 43737 | 50477097 |
Anhedonia | 19.92 | 9.77 | 47 | 84243 | 9477 | 50511357 |
Lip erosion | 19.89 | 9.77 | 14 | 84276 | 810 | 50520024 |
Choluria | 19.73 | 9.77 | 8 | 84282 | 147 | 50520687 |
Oedema | 19.71 | 9.77 | 191 | 84099 | 69990 | 50450844 |
Coma | 19.42 | 9.77 | 41 | 84249 | 56838 | 50463996 |
Gastrointestinal disorder | 19.42 | 9.77 | 86 | 84204 | 94370 | 50426464 |
Respiratory failure | 19.36 | 9.77 | 82 | 84208 | 91099 | 50429735 |
Osteonecrosis of jaw | 19.34 | 9.77 | 106 | 84184 | 32420 | 50488414 |
Mouth swelling | 19.32 | 9.77 | 28 | 84262 | 3888 | 50516946 |
Blood pressure increased | 19.30 | 9.77 | 136 | 84154 | 132996 | 50387838 |
Multiple sclerosis relapse | 19.25 | 9.77 | 26 | 84264 | 42938 | 50477896 |
Blood glucose increased | 19.24 | 9.77 | 58 | 84232 | 71266 | 50449568 |
Pulmonary artery stenosis congenital | 19.22 | 9.77 | 9 | 84281 | 237 | 50520597 |
Peripheral swelling | 19.21 | 9.77 | 235 | 84055 | 205701 | 50315133 |
Nasopharyngitis | 18.82 | 9.77 | 218 | 84072 | 192709 | 50328125 |
Eosinophils urine present | 18.79 | 9.77 | 5 | 84285 | 21 | 50520813 |
Neutropenic sepsis | 18.72 | 9.77 | 59 | 84231 | 14088 | 50506746 |
Symmetrical drug-related intertriginous and flexural exanthema | 18.69 | 9.77 | 10 | 84280 | 352 | 50520482 |
Psoriatic arthropathy | 18.61 | 9.77 | 31 | 84259 | 47001 | 50473833 |
Labile blood pressure | 18.49 | 9.77 | 18 | 84272 | 1642 | 50519192 |
Biliary dyskinesia | 18.43 | 9.77 | 22 | 84268 | 2528 | 50518306 |
International normalised ratio increased | 18.34 | 9.77 | 129 | 84161 | 43023 | 50477811 |
Laryngeal discomfort | 17.99 | 9.77 | 9 | 84281 | 275 | 50520559 |
Exposure during pregnancy | 17.84 | 9.77 | 292 | 83998 | 120723 | 50400111 |
Mouth ulceration | 17.80 | 9.77 | 93 | 84197 | 27931 | 50492903 |
Myocardial infarction | 17.73 | 9.77 | 82 | 84208 | 88945 | 50431889 |
Fluid retention | 17.72 | 9.77 | 36 | 84254 | 50613 | 50470221 |
Sedation | 17.64 | 9.77 | 15 | 84275 | 30595 | 50490239 |
Fibromyalgia | 17.47 | 9.77 | 30 | 84260 | 44948 | 50475886 |
Pharyngeal swelling | 17.42 | 9.77 | 29 | 84261 | 4537 | 50516297 |
Septic shock | 17.28 | 9.77 | 44 | 84246 | 57131 | 50463703 |
Eosinophilic pneumonia acute | 17.24 | 9.77 | 9 | 84281 | 301 | 50520533 |
Medication error | 17.19 | 9.77 | 111 | 84179 | 35993 | 50484841 |
Biliary colic | 17.11 | 9.77 | 24 | 84266 | 3235 | 50517599 |
Hepatic failure | 17.09 | 9.77 | 102 | 84188 | 32181 | 50488653 |
SJS-TEN overlap | 17.00 | 9.77 | 8 | 84282 | 213 | 50520621 |
Incorrect route of product administration | 16.96 | 9.77 | 5 | 84285 | 18661 | 50502173 |
Skin reaction | 16.95 | 9.77 | 50 | 84240 | 11518 | 50509316 |
Norovirus test positive | 16.90 | 9.77 | 7 | 84283 | 136 | 50520698 |
Tryptase increased | 16.83 | 9.77 | 8 | 84282 | 218 | 50520616 |
Neutrophilia | 16.82 | 9.77 | 25 | 84265 | 3550 | 50517284 |
Odynophagia | 16.78 | 9.77 | 35 | 84255 | 6497 | 50514337 |
Swelling of eyelid | 16.77 | 9.77 | 18 | 84272 | 1842 | 50518992 |
Genital erosion | 16.54 | 9.77 | 7 | 84283 | 144 | 50520690 |
Dyspnoea | 16.51 | 9.77 | 1090 | 83200 | 546518 | 49974316 |
Diastasis recti abdominis | 16.42 | 9.77 | 5 | 84285 | 37 | 50520797 |
Hepatitis acute | 16.34 | 9.77 | 39 | 84251 | 7922 | 50512912 |
Behaviour disorder | 16.33 | 9.77 | 20 | 84270 | 2360 | 50518474 |
Atrial septal defect | 16.32 | 9.77 | 34 | 84256 | 6307 | 50514527 |
Blood cholesterol increased | 16.29 | 9.77 | 43 | 84247 | 55172 | 50465662 |
Red blood cell sedimentation rate increased | 16.25 | 9.77 | 15 | 84275 | 29401 | 50491433 |
Joint injury | 16.20 | 9.77 | 8 | 84282 | 21781 | 50499053 |
Congenital melanocytic naevus | 16.20 | 9.77 | 3 | 84287 | 0 | 50520834 |
Diabetes mellitus | 16.19 | 9.77 | 36 | 84254 | 48997 | 50471837 |
Deep vein thrombosis | 16.14 | 9.77 | 190 | 84100 | 73114 | 50447720 |
Bipolar I disorder | 16.05 | 9.77 | 16 | 84274 | 1502 | 50519332 |
Pharyngotonsillitis | 15.98 | 9.77 | 7 | 84283 | 157 | 50520677 |
Glomerulonephritis acute | 15.97 | 9.77 | 5 | 84285 | 41 | 50520793 |
Lymphocytosis | 15.92 | 9.77 | 19 | 84271 | 2183 | 50518651 |
Dysphonia | 15.80 | 9.77 | 115 | 84175 | 38777 | 50482057 |
Underdose | 15.76 | 9.77 | 7 | 84283 | 20271 | 50500563 |
Serotonin syndrome | 15.65 | 9.77 | 11 | 84279 | 24702 | 50496132 |
Haematuria | 15.58 | 9.77 | 84 | 84206 | 25529 | 50495305 |
Nail dystrophy | 15.56 | 9.77 | 12 | 84278 | 799 | 50520035 |
Polymenorrhagia | 15.56 | 9.77 | 5 | 84285 | 45 | 50520789 |
Tubulointerstitial nephritis and uveitis syndrome | 15.50 | 9.77 | 7 | 84283 | 169 | 50520665 |
Cardiac failure congestive | 15.49 | 9.77 | 80 | 84210 | 84302 | 50436532 |
Femoral artery embolism | 15.27 | 9.77 | 5 | 84285 | 48 | 50520786 |
Rash papular | 15.27 | 9.77 | 51 | 84239 | 12553 | 50508281 |
Nasal polyps | 15.21 | 9.77 | 20 | 84270 | 2534 | 50518300 |
Fixed eruption | 15.20 | 9.77 | 12 | 84278 | 827 | 50520007 |
PRIDE syndrome | 15.19 | 9.77 | 4 | 84286 | 16 | 50520818 |
Skin exfoliation | 15.19 | 9.77 | 102 | 84188 | 33510 | 50487324 |
Cardiac failure | 15.17 | 9.77 | 70 | 84220 | 75970 | 50444864 |
Budd-Chiari syndrome | 15.09 | 9.77 | 5 | 84285 | 50 | 50520784 |
General physical health deterioration | 15.06 | 9.77 | 158 | 84132 | 142276 | 50378558 |
Accidental exposure to product | 14.95 | 9.77 | 10 | 84280 | 23047 | 50497787 |
Tangentiality | 14.81 | 9.77 | 4 | 84286 | 18 | 50520816 |
Sebaceous gland infection | 14.76 | 9.77 | 6 | 84284 | 111 | 50520723 |
Tooth discolouration | 14.71 | 9.77 | 12 | 84278 | 867 | 50519967 |
Pseudomyopia | 14.66 | 9.77 | 5 | 84285 | 55 | 50520779 |
Mixed liver injury | 14.64 | 9.77 | 23 | 84267 | 3428 | 50517406 |
Respiratory symptom | 14.53 | 9.77 | 19 | 84271 | 2395 | 50518439 |
Forced vital capacity abnormal | 14.46 | 9.77 | 4 | 84286 | 20 | 50520814 |
Pain | 14.46 | 9.77 | 803 | 83487 | 578100 | 49942734 |
Hypoaesthesia oral | 14.44 | 9.77 | 45 | 84245 | 10683 | 50510151 |
Gallbladder cholesterolosis | 14.42 | 9.77 | 11 | 84279 | 721 | 50520113 |
Caffeine allergy | 14.30 | 9.77 | 4 | 84286 | 21 | 50520813 |
Fear-related avoidance of activities | 14.28 | 9.77 | 6 | 84284 | 121 | 50520713 |
Cell death | 14.22 | 9.77 | 18 | 84272 | 2197 | 50518637 |
Atrophy | 14.20 | 9.77 | 15 | 84275 | 1508 | 50519326 |
Injection site haemorrhage | 14.19 | 9.77 | 9 | 84281 | 21337 | 50499497 |
Contusion | 14.19 | 9.77 | 119 | 84171 | 112064 | 50408770 |
Tongue pruritus | 14.16 | 9.77 | 9 | 84281 | 439 | 50520395 |
Cholestasis of pregnancy | 14.00 | 9.77 | 13 | 84277 | 1118 | 50519716 |
Injection site warmth | 13.98 | 9.77 | 3 | 84287 | 13863 | 50506971 |
Mania | 13.97 | 9.77 | 45 | 84245 | 10871 | 50509963 |
Mucosal discolouration | 13.92 | 9.77 | 9 | 84281 | 452 | 50520382 |
Fulminant type 1 diabetes mellitus | 13.91 | 9.77 | 8 | 84282 | 325 | 50520509 |
Foetal hypokinesia | 13.89 | 9.77 | 9 | 84281 | 454 | 50520380 |
Coagulopathy | 13.87 | 9.77 | 63 | 84227 | 17881 | 50502953 |
Cheilitis | 13.87 | 9.77 | 23 | 84267 | 3587 | 50517247 |
Monoclonal gammopathy | 13.84 | 9.77 | 10 | 84280 | 603 | 50520231 |
Pharyngitis streptococcal | 13.80 | 9.77 | 39 | 84251 | 8769 | 50512065 |
Mucosal inflammation | 13.70 | 9.77 | 114 | 84176 | 40028 | 50480806 |
Reaction to excipient | 13.70 | 9.77 | 13 | 84277 | 1149 | 50519685 |
Actinomycosis | 13.69 | 9.77 | 12 | 84278 | 957 | 50519877 |
Sweat discolouration | 13.66 | 9.77 | 3 | 84287 | 4 | 50520830 |
Conjunctivitis | 13.48 | 9.77 | 58 | 84232 | 16087 | 50504747 |
Haemolytic anaemia | 13.46 | 9.77 | 40 | 84250 | 9252 | 50511582 |
Gamma-glutamyltransferase increased | 13.45 | 9.77 | 90 | 84200 | 29533 | 50491301 |
Lip pain | 13.33 | 9.77 | 15 | 84275 | 1619 | 50519215 |
Cholecystitis | 13.29 | 9.77 | 52 | 84238 | 13819 | 50507015 |
Injection site reaction | 13.27 | 9.77 | 41 | 84249 | 49991 | 50470843 |
Delusion of grandeur | 13.21 | 9.77 | 6 | 84284 | 147 | 50520687 |
Lymphadenitis | 13.09 | 9.77 | 19 | 84271 | 2641 | 50518193 |
Skin swelling | 13.05 | 9.77 | 17 | 84273 | 2135 | 50518699 |
Human herpesvirus 6 encephalitis | 12.99 | 9.77 | 6 | 84284 | 153 | 50520681 |
Full blood count abnormal | 12.83 | 9.77 | 12 | 84278 | 23376 | 50497458 |
Toothache | 12.83 | 9.77 | 59 | 84231 | 16835 | 50503999 |
Therapy non-responder | 12.70 | 9.77 | 43 | 84247 | 50979 | 50469855 |
Pharyngeal abscess | 12.67 | 9.77 | 7 | 84283 | 263 | 50520571 |
Allergy test negative | 12.60 | 9.77 | 3 | 84287 | 7 | 50520827 |
Lice infestation | 12.60 | 9.77 | 3 | 84287 | 7 | 50520827 |
Palatal swelling | 12.58 | 9.77 | 5 | 84285 | 87 | 50520747 |
Erythema nodosum | 12.56 | 9.77 | 23 | 84267 | 3880 | 50516954 |
Rash pustular | 12.50 | 9.77 | 31 | 84259 | 6450 | 50514384 |
Facial paralysis | 12.46 | 9.77 | 48 | 84242 | 12667 | 50508167 |
Klebsiella infection | 12.42 | 9.77 | 33 | 84257 | 7161 | 50513673 |
Embolism venous | 12.38 | 9.77 | 18 | 84272 | 2507 | 50518327 |
Delayed delivery | 12.35 | 9.77 | 4 | 84286 | 37 | 50520797 |
Hypertension | 12.34 | 9.77 | 263 | 84027 | 210940 | 50309894 |
Platelet count decreased | 12.22 | 9.77 | 108 | 84182 | 100618 | 50420216 |
Lymphocyte morphology abnormal | 12.19 | 9.77 | 8 | 84282 | 412 | 50520422 |
Macule | 12.16 | 9.77 | 14 | 84276 | 1548 | 50519286 |
Congenital tricuspid valve incompetence | 12.08 | 9.77 | 5 | 84285 | 97 | 50520737 |
Genital prolapse | 12.07 | 9.77 | 4 | 84286 | 40 | 50520794 |
Pneumopericardium | 11.98 | 9.77 | 4 | 84286 | 41 | 50520793 |
Injection site rash | 11.94 | 9.77 | 6 | 84284 | 16171 | 50504663 |
Vitiligo | 11.90 | 9.77 | 12 | 84278 | 1142 | 50519692 |
Localised infection | 11.85 | 9.77 | 15 | 84275 | 25470 | 50495364 |
Ear infection | 11.85 | 9.77 | 79 | 84211 | 25891 | 50494943 |
Delirium | 11.84 | 9.77 | 29 | 84261 | 38163 | 50482671 |
Cognitive disorder | 11.81 | 9.77 | 36 | 84254 | 44087 | 50476747 |
Wrong technique in product usage process | 11.73 | 9.77 | 50 | 84240 | 55460 | 50465374 |
Periorbital swelling | 11.65 | 9.77 | 15 | 84275 | 1862 | 50518972 |
Right ventricular failure | 11.57 | 9.77 | 6 | 84284 | 15887 | 50504947 |
Fibrous histiocytoma | 11.55 | 9.77 | 8 | 84282 | 451 | 50520383 |
Target skin lesion | 11.54 | 9.77 | 5 | 84285 | 109 | 50520725 |
Anxiety | 11.53 | 9.77 | 382 | 83908 | 177224 | 50343610 |
Oropharyngeal discomfort | 11.50 | 9.77 | 22 | 84268 | 3836 | 50516998 |
Eosinophilic pneumonia | 11.48 | 9.77 | 15 | 84275 | 1889 | 50518945 |
Hypotonia neonatal | 11.46 | 9.77 | 11 | 84279 | 986 | 50519848 |
Infectious mononucleosis | 11.43 | 9.77 | 14 | 84276 | 1652 | 50519182 |
Premature delivery | 11.41 | 9.77 | 73 | 84217 | 23590 | 50497244 |
Non-alcoholic steatohepatitis | 11.41 | 9.77 | 13 | 84277 | 1422 | 50519412 |
Abnormal faeces | 11.39 | 9.77 | 23 | 84267 | 4173 | 50516661 |
Injection site bruising | 11.34 | 9.77 | 28 | 84262 | 36740 | 50484094 |
Respiratory depression | 11.31 | 9.77 | 3 | 84287 | 12007 | 50508827 |
Hypovolaemic shock | 11.28 | 9.77 | 26 | 84264 | 5162 | 50515672 |
Tooth disorder | 11.23 | 9.77 | 74 | 84216 | 24154 | 50496680 |
Crepitations | 11.22 | 9.77 | 29 | 84261 | 6190 | 50514644 |
Tonsillitis streptococcal | 11.20 | 9.77 | 4 | 84286 | 51 | 50520783 |
Foetal distress syndrome | 11.14 | 9.77 | 12 | 84278 | 1233 | 50519601 |
Hypersensitivity | 11.10 | 9.77 | 451 | 83839 | 214710 | 50306124 |
Actinic keratosis | 11.10 | 9.77 | 16 | 84274 | 2211 | 50518623 |
Hepatic necrosis | 11.08 | 9.77 | 26 | 84264 | 5222 | 50515612 |
Bone disorder | 11.07 | 9.77 | 61 | 84229 | 18691 | 50502143 |
Linear IgA disease | 11.07 | 9.77 | 12 | 84278 | 1242 | 50519592 |
Dysphagia | 11.03 | 9.77 | 186 | 84104 | 77332 | 50443502 |
Incision site haemorrhage | 11.00 | 9.77 | 8 | 84282 | 487 | 50520347 |
Cholelithiasis | 10.98 | 9.77 | 104 | 84186 | 37869 | 50482965 |
Pneumonia mycoplasmal | 10.98 | 9.77 | 10 | 84280 | 839 | 50519995 |
Anion gap increased | 10.95 | 9.77 | 13 | 84277 | 1486 | 50519348 |
Hepatitis toxic | 10.90 | 9.77 | 18 | 84272 | 2798 | 50518036 |
Mental status changes | 10.89 | 9.77 | 28 | 84262 | 36244 | 50484590 |
Spinal subdural haematoma | 10.88 | 9.77 | 5 | 84285 | 126 | 50520708 |
Erythromelalgia | 10.88 | 9.77 | 5 | 84285 | 126 | 50520708 |
Carcinoid crisis | 10.87 | 9.77 | 6 | 84284 | 225 | 50520609 |
Bone erosion | 10.86 | 9.77 | 3 | 84287 | 11684 | 50509150 |
Death neonatal | 10.84 | 9.77 | 6 | 84284 | 226 | 50520608 |
Herpes simplex test positive | 10.81 | 9.77 | 5 | 84285 | 128 | 50520706 |
Tonsillar hypertrophy | 10.81 | 9.77 | 10 | 84280 | 856 | 50519978 |
Pharyngeal erythema | 10.72 | 9.77 | 13 | 84277 | 1519 | 50519315 |
Caesarean section | 10.70 | 9.77 | 53 | 84237 | 15586 | 50505248 |
Hepatosplenomegaly | 10.64 | 9.77 | 16 | 84274 | 2296 | 50518538 |
Injury corneal | 10.61 | 9.77 | 4 | 84286 | 60 | 50520774 |
Sacroiliitis | 10.59 | 9.77 | 17 | 84273 | 2580 | 50518254 |
Anaemia | 10.57 | 9.77 | 330 | 83960 | 252126 | 50268708 |
Maternal drugs affecting foetus | 10.56 | 9.77 | 25 | 84265 | 5052 | 50515782 |
Product complaint | 10.55 | 9.77 | 3 | 84287 | 11463 | 50509371 |
Lip ulceration | 10.54 | 9.77 | 14 | 84276 | 1791 | 50519043 |
Tongue haemorrhage | 10.54 | 9.77 | 7 | 84283 | 368 | 50520466 |
Pleural effusion | 10.48 | 9.77 | 86 | 84204 | 81368 | 50439466 |
Enanthema | 10.47 | 9.77 | 7 | 84283 | 372 | 50520462 |
Lip discolouration | 10.45 | 9.77 | 8 | 84282 | 527 | 50520307 |
Jaundice cholestatic | 10.45 | 9.77 | 25 | 84265 | 5086 | 50515748 |
Helicobacter test positive | 10.37 | 9.77 | 7 | 84283 | 378 | 50520456 |
Blood test abnormal | 10.34 | 9.77 | 3 | 84287 | 11316 | 50509518 |
Intentional self-injury | 10.34 | 9.77 | 14 | 84276 | 23098 | 50497736 |
Depressed level of consciousness | 10.26 | 9.77 | 48 | 84242 | 51905 | 50468929 |
Prescribed underdose | 10.23 | 9.77 | 7 | 84283 | 15942 | 50504892 |
Feeling hot | 10.18 | 9.77 | 105 | 84185 | 39097 | 50481737 |
Inappropriate schedule of product administration | 10.10 | 9.77 | 74 | 84216 | 71757 | 50449077 |
Palpitations | 10.10 | 9.77 | 217 | 84073 | 94289 | 50426545 |
Rheumatic fever | 10.05 | 9.77 | 8 | 84282 | 16859 | 50503975 |
Claudication of jaw muscles | 10.04 | 9.77 | 4 | 84286 | 70 | 50520764 |
Transaminases increased | 10.03 | 9.77 | 80 | 84210 | 27744 | 50493090 |
Fracture | 10.01 | 9.77 | 8 | 84282 | 16825 | 50504009 |
Sebaceous gland disorder | 9.99 | 9.77 | 3 | 84287 | 21 | 50520813 |
Multiple lentigines syndrome | 9.99 | 9.77 | 5 | 84285 | 153 | 50520681 |
Overdose | 9.98 | 9.77 | 112 | 84178 | 99615 | 50421219 |
Neoplasm progression | 9.96 | 9.77 | 21 | 84269 | 29136 | 50491698 |
Metastases to lung | 9.92 | 9.77 | 3 | 84287 | 11017 | 50509817 |
Pyrexia | 9.89 | 9.77 | 748 | 83542 | 379455 | 50141379 |
Hypersensitivity myocarditis | 9.87 | 9.77 | 3 | 84287 | 22 | 50520812 |
Nephritis allergic | 9.87 | 9.77 | 5 | 84285 | 157 | 50520677 |
Product storage error | 9.85 | 9.77 | 4 | 84286 | 12220 | 50508614 |
Female genital tract fistula | 9.84 | 9.77 | 20 | 84270 | 3646 | 50517188 |
Labelled drug-drug interaction medication error | 9.82 | 9.77 | 39 | 84251 | 10438 | 50510396 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug reaction with eosinophilia and systemic symptoms | 437.84 | 10.40 | 382 | 53724 | 27610 | 29492811 |
Pruritus | 406.55 | 10.40 | 749 | 53357 | 116100 | 29404321 |
Urticaria | 398.15 | 10.40 | 495 | 53611 | 54165 | 29466256 |
Anaphylactic shock | 382.49 | 10.40 | 261 | 53845 | 13075 | 29507346 |
Rash maculo-papular | 249.52 | 10.40 | 263 | 53843 | 24026 | 29496395 |
Rash | 247.06 | 10.40 | 835 | 53271 | 188984 | 29331437 |
Erythema | 221.26 | 10.40 | 451 | 53655 | 75155 | 29445266 |
Anaphylactic reaction | 217.20 | 10.40 | 260 | 53846 | 27313 | 29493108 |
Angioedema | 216.22 | 10.40 | 279 | 53827 | 31636 | 29488785 |
Meningitis aseptic | 202.44 | 10.40 | 95 | 54011 | 2281 | 29518140 |
Acute generalised exanthematous pustulosis | 198.41 | 10.40 | 125 | 53981 | 5458 | 29514963 |
Lip oedema | 196.71 | 10.40 | 91 | 54015 | 2113 | 29518308 |
Drug hypersensitivity | 175.68 | 10.40 | 387 | 53719 | 68019 | 29452402 |
Death | 165.06 | 10.40 | 232 | 53874 | 341852 | 29178569 |
Eosinophilia | 163.18 | 10.40 | 202 | 53904 | 21959 | 29498462 |
Cross sensitivity reaction | 150.96 | 10.40 | 64 | 54042 | 1198 | 29519223 |
Face oedema | 128.75 | 10.40 | 124 | 53982 | 10159 | 29510262 |
Acute kidney injury | 122.76 | 10.40 | 867 | 53239 | 264400 | 29256021 |
Hepatocellular injury | 119.90 | 10.40 | 170 | 53936 | 21073 | 29499348 |
Crystalluria | 119.35 | 10.40 | 40 | 54066 | 375 | 29520046 |
Cholestasis | 118.27 | 10.40 | 178 | 53928 | 23284 | 29497137 |
Lip swelling | 116.18 | 10.40 | 128 | 53978 | 12282 | 29508139 |
Stevens-Johnson syndrome | 105.11 | 10.40 | 140 | 53966 | 16357 | 29504064 |
Type I hypersensitivity | 104.28 | 10.40 | 47 | 54059 | 1025 | 29519396 |
Toxic epidermal necrolysis | 100.56 | 10.40 | 144 | 53962 | 18009 | 29502412 |
Wound closure | 99.77 | 10.40 | 24 | 54082 | 52 | 29520369 |
Osteotomy | 98.55 | 10.40 | 24 | 54082 | 56 | 29520365 |
Hypersensitivity | 85.20 | 10.40 | 251 | 53855 | 52652 | 29467769 |
Kounis syndrome | 83.21 | 10.40 | 48 | 54058 | 1781 | 29518640 |
Rash erythematous | 79.43 | 10.40 | 142 | 53964 | 21420 | 29499001 |
Completed suicide | 77.54 | 10.40 | 34 | 54072 | 90212 | 29430209 |
Fixed eruption | 75.36 | 10.40 | 39 | 54067 | 1163 | 29519258 |
Drug abuse | 70.37 | 10.40 | 29 | 54077 | 79854 | 29440567 |
Eyelid oedema | 69.84 | 10.40 | 62 | 54044 | 4574 | 29515847 |
Enterocolitis haemorrhagic | 69.38 | 10.40 | 33 | 54073 | 817 | 29519604 |
Swollen tongue | 68.96 | 10.40 | 98 | 54008 | 12168 | 29508253 |
Tubulointerstitial nephritis | 67.31 | 10.40 | 118 | 53988 | 17525 | 29502896 |
Toxic skin eruption | 63.99 | 10.40 | 84 | 54022 | 9673 | 29510748 |
Drug ineffective | 63.64 | 10.40 | 397 | 53709 | 362773 | 29157648 |
Tooth disorder | 62.44 | 10.40 | 82 | 54024 | 9447 | 29510974 |
Tongue oedema | 61.42 | 10.40 | 45 | 54061 | 2521 | 29517900 |
Swelling face | 61.29 | 10.40 | 123 | 53983 | 20227 | 29500194 |
Toxicity to various agents | 60.84 | 10.40 | 143 | 53963 | 173518 | 29346903 |
Rash morbilliform | 55.82 | 10.40 | 42 | 54064 | 2451 | 29517970 |
Acute psychosis | 55.53 | 10.40 | 36 | 54070 | 1651 | 29518770 |
Fall | 54.32 | 10.40 | 156 | 53950 | 177022 | 29343399 |
Off label use | 49.46 | 10.40 | 335 | 53771 | 300465 | 29219956 |
Disease progression | 48.46 | 10.40 | 47 | 54059 | 81869 | 29438552 |
Premature baby | 47.97 | 10.40 | 101 | 54005 | 17179 | 29503242 |
Crystal nephropathy | 44.50 | 10.40 | 19 | 54087 | 362 | 29520059 |
Dermatitis exfoliative generalised | 43.93 | 10.40 | 39 | 54067 | 2877 | 29517544 |
Type IV hypersensitivity reaction | 43.50 | 10.40 | 27 | 54079 | 1147 | 29519274 |
Helicobacter test positive | 43.00 | 10.40 | 22 | 54084 | 640 | 29519781 |
Malignant neoplasm progression | 42.97 | 10.40 | 43 | 54063 | 73816 | 29446605 |
Serum sickness-like reaction | 37.92 | 10.40 | 12 | 54094 | 92 | 29520329 |
Rash pruritic | 37.79 | 10.40 | 108 | 53998 | 22255 | 29498166 |
Degenerative mitral valve disease | 35.85 | 10.40 | 14 | 54092 | 210 | 29520211 |
Hepatitis cholestatic | 35.72 | 10.40 | 53 | 54053 | 6840 | 29513581 |
Drug-induced liver injury | 35.07 | 10.40 | 103 | 54003 | 21552 | 29498869 |
Ureteric compression | 35.05 | 10.40 | 13 | 54093 | 168 | 29520253 |
Neutropenia neonatal | 34.65 | 10.40 | 19 | 54087 | 638 | 29519783 |
Tooth demineralisation | 34.65 | 10.40 | 7 | 54099 | 3 | 29520418 |
Febrile neutropenia | 34.22 | 10.40 | 99 | 54007 | 112141 | 29408280 |
Foetal disorder | 34.16 | 10.40 | 20 | 54086 | 763 | 29519658 |
Clostridium difficile colitis | 34.12 | 10.40 | 75 | 54031 | 13137 | 29507284 |
Jaundice cholestatic | 33.49 | 10.40 | 40 | 54066 | 4186 | 29516235 |
Conjunctival irritation | 33.31 | 10.40 | 11 | 54095 | 98 | 29520323 |
Dyspnoea | 33.08 | 10.40 | 806 | 53300 | 325926 | 29194495 |
Otospondylomegaepiphyseal dysplasia | 32.83 | 10.40 | 11 | 54095 | 103 | 29520318 |
Liver injury | 32.73 | 10.40 | 72 | 54034 | 12618 | 29507803 |
Hepatitis acute | 32.51 | 10.40 | 49 | 54057 | 6413 | 29514008 |
Fatigue | 32.31 | 10.40 | 398 | 53708 | 316423 | 29203998 |
Bradycardia | 31.95 | 10.40 | 44 | 54062 | 65585 | 29454836 |
Factitious disorder | 31.23 | 10.40 | 9 | 54097 | 48 | 29520373 |
Cardiac failure congestive | 31.01 | 10.40 | 58 | 54048 | 76523 | 29443898 |
Malaise | 30.99 | 10.40 | 436 | 53670 | 159166 | 29361255 |
Myocardial infarction | 30.98 | 10.40 | 101 | 54005 | 110195 | 29410226 |
Bone disorder | 30.74 | 10.40 | 45 | 54061 | 5738 | 29514683 |
Rash macular | 30.18 | 10.40 | 62 | 54044 | 10363 | 29510058 |
Helicobacter infection | 30.14 | 10.40 | 27 | 54079 | 2015 | 29518406 |
Rash vesicular | 29.96 | 10.40 | 29 | 54077 | 2389 | 29518032 |
Rash papular | 29.94 | 10.40 | 53 | 54053 | 7928 | 29512493 |
Laryngeal dyspnoea | 29.91 | 10.40 | 10 | 54096 | 93 | 29520328 |
Dermatitis allergic | 29.86 | 10.40 | 44 | 54062 | 5644 | 29514777 |
Mouth swelling | 29.75 | 10.40 | 24 | 54082 | 1552 | 29518869 |
Drug eruption | 29.41 | 10.40 | 82 | 54024 | 16659 | 29503762 |
Erythema multiforme | 28.63 | 10.40 | 51 | 54055 | 7666 | 29512755 |
Documented hypersensitivity to administered product | 28.28 | 10.40 | 12 | 54094 | 225 | 29520196 |
Skin test positive | 28.13 | 10.40 | 13 | 54093 | 301 | 29520120 |
Mixed liver injury | 28.09 | 10.40 | 26 | 54080 | 2025 | 29518396 |
Ureteral disorder | 27.93 | 10.40 | 11 | 54095 | 169 | 29520252 |
Secondary amyloidosis | 27.89 | 10.40 | 9 | 54097 | 74 | 29520347 |
Malignant mesenteric neoplasm | 27.55 | 10.40 | 8 | 54098 | 44 | 29520377 |
Eye injury | 27.36 | 10.40 | 16 | 54090 | 609 | 29519812 |
Jaundice | 27.20 | 10.40 | 116 | 53990 | 29180 | 29491241 |
Conjunctival hyperaemia | 27.09 | 10.40 | 26 | 54080 | 2119 | 29518302 |
Hepatic cytolysis | 27.00 | 10.40 | 52 | 54054 | 8295 | 29512126 |
Injection site pain | 26.64 | 10.40 | 13 | 54093 | 32433 | 29487988 |
Acute hepatic failure | 26.62 | 10.40 | 64 | 54042 | 11888 | 29508533 |
Tachycardia foetal | 26.32 | 10.40 | 12 | 54094 | 269 | 29520152 |
Urethral valves | 26.24 | 10.40 | 12 | 54094 | 271 | 29520150 |
Conjunctivitis | 26.08 | 10.40 | 50 | 54056 | 7948 | 29512473 |
Wheezing | 25.92 | 10.40 | 125 | 53981 | 33115 | 29487306 |
Skin reaction | 25.87 | 10.40 | 36 | 54070 | 4381 | 29516040 |
Pulmonary vascular disorder | 25.87 | 10.40 | 15 | 54091 | 562 | 29519859 |
Nicotine dependence | 25.46 | 10.40 | 14 | 54092 | 473 | 29519948 |
Therapeutic product effect decreased | 25.42 | 10.40 | 11 | 54095 | 29440 | 29490981 |
Low birth weight baby | 24.94 | 10.40 | 44 | 54062 | 6564 | 29513857 |
Penile erythema | 24.90 | 10.40 | 10 | 54096 | 162 | 29520259 |
Laryngeal oedema | 24.40 | 10.40 | 29 | 54077 | 3019 | 29517402 |
Jejunal ulcer perforation | 24.36 | 10.40 | 8 | 54098 | 70 | 29520351 |
Dermatomyositis | 24.23 | 10.40 | 18 | 54088 | 1030 | 29519391 |
Bronchospasm | 24.19 | 10.40 | 54 | 54052 | 9555 | 29510866 |
Haemoglobin decreased | 24.13 | 10.40 | 109 | 53997 | 108266 | 29412155 |
Cerebrovascular accident | 24.04 | 10.40 | 67 | 54039 | 76844 | 29443577 |
Periorbital oedema | 24.03 | 10.40 | 30 | 54076 | 3285 | 29517136 |
Ultrasound liver abnormal | 24.01 | 10.40 | 9 | 54097 | 120 | 29520301 |
Attention-seeking behaviour | 23.88 | 10.40 | 7 | 54099 | 40 | 29520381 |
Metastases to stomach | 23.77 | 10.40 | 8 | 54098 | 76 | 29520345 |
Tooth infection | 23.70 | 10.40 | 39 | 54067 | 5500 | 29514921 |
White blood cell count decreased | 23.63 | 10.40 | 76 | 54030 | 83286 | 29437135 |
Cardiac aneurysm | 23.34 | 10.40 | 16 | 54090 | 806 | 29519615 |
Ventricular enlargement | 23.32 | 10.40 | 13 | 54093 | 451 | 29519970 |
Pyelocaliectasis | 23.32 | 10.40 | 18 | 54088 | 1091 | 29519330 |
Sensation of foreign body | 23.18 | 10.40 | 22 | 54084 | 1768 | 29518653 |
Vanishing bile duct syndrome | 23.00 | 10.40 | 14 | 54092 | 574 | 29519847 |
Anaemia | 22.94 | 10.40 | 246 | 53860 | 200705 | 29319716 |
Macroglossia | 22.85 | 10.40 | 12 | 54094 | 369 | 29520052 |
Platelet count decreased | 22.28 | 10.40 | 107 | 53999 | 104565 | 29415856 |
Purpura | 22.26 | 10.40 | 51 | 54055 | 9181 | 29511240 |
Rheumatoid arthritis | 22.01 | 10.40 | 16 | 54090 | 32136 | 29488285 |
Dermatitis bullous | 21.87 | 10.40 | 39 | 54067 | 5867 | 29514554 |
Sensitisation | 21.81 | 10.40 | 9 | 54097 | 157 | 29520264 |
Inferior vena cava dilatation | 21.19 | 10.40 | 14 | 54092 | 663 | 29519758 |
Omental necrosis | 21.14 | 10.40 | 6 | 54100 | 30 | 29520391 |
Rash scarlatiniform | 21.12 | 10.40 | 8 | 54098 | 110 | 29520311 |
Weight increased | 20.97 | 10.40 | 71 | 54035 | 76596 | 29443825 |
Hallucinations, mixed | 20.89 | 10.40 | 24 | 54082 | 2409 | 29518012 |
Eastern Cooperative Oncology Group performance status | 20.66 | 10.40 | 6 | 54100 | 33 | 29520388 |
Therapeutic product effect incomplete | 20.52 | 10.40 | 25 | 54081 | 39280 | 29481141 |
Tissue infiltration | 20.39 | 10.40 | 7 | 54099 | 71 | 29520350 |
Dental operation | 20.35 | 10.40 | 11 | 54095 | 359 | 29520062 |
Gingivitis | 20.34 | 10.40 | 26 | 54080 | 2916 | 29517505 |
Macule | 20.30 | 10.40 | 16 | 54090 | 1000 | 29519421 |
Hyperglycaemia | 19.88 | 10.40 | 20 | 54086 | 34267 | 29486154 |
Prothrombin time shortened | 19.68 | 10.40 | 18 | 54088 | 1380 | 29519041 |
Tubulointerstitial nephritis and uveitis syndrome | 19.41 | 10.40 | 7 | 54099 | 83 | 29520338 |
Toothache | 19.35 | 10.40 | 36 | 54070 | 5596 | 29514825 |
Faeces pale | 19.29 | 10.40 | 17 | 54089 | 1242 | 29519179 |
Pyrexia | 19.00 | 10.40 | 673 | 53433 | 286949 | 29233472 |
Infective exacerbation of chronic obstructive airways disease | 18.97 | 10.40 | 19 | 54087 | 1631 | 29518790 |
Laryngeal discomfort | 18.95 | 10.40 | 8 | 54098 | 148 | 29520273 |
Oral mucosal blistering | 18.91 | 10.40 | 19 | 54087 | 1638 | 29518783 |
Cardiac failure | 18.71 | 10.40 | 78 | 54028 | 79209 | 29441212 |
Rash pustular | 18.70 | 10.40 | 32 | 54074 | 4659 | 29515762 |
Henoch-Schonlein purpura | 18.64 | 10.40 | 17 | 54089 | 1299 | 29519122 |
Rebound acid hypersecretion | 18.63 | 10.40 | 7 | 54099 | 94 | 29520327 |
Cerebral infarction | 18.62 | 10.40 | 11 | 54095 | 24664 | 29495757 |
Genital cyst | 18.46 | 10.40 | 4 | 54102 | 4 | 29520417 |
Plica syndrome | 18.46 | 10.40 | 4 | 54102 | 4 | 29520417 |
Melanocytic hyperplasia | 18.46 | 10.40 | 4 | 54102 | 4 | 29520417 |
Occult blood | 18.36 | 10.40 | 12 | 54094 | 558 | 29519863 |
Diarrhoea haemorrhagic | 18.28 | 10.40 | 36 | 54070 | 5838 | 29514583 |
Hypersensitivity vasculitis | 18.27 | 10.40 | 26 | 54080 | 3231 | 29517190 |
Product use issue | 18.25 | 10.40 | 42 | 54064 | 51402 | 29469019 |
Rectal polyp | 18.21 | 10.40 | 12 | 54094 | 566 | 29519855 |
Foetal exposure during pregnancy | 18.11 | 10.40 | 115 | 53991 | 33752 | 29486669 |
Genital erythema | 17.94 | 10.40 | 8 | 54098 | 170 | 29520251 |
Palatal oedema | 17.90 | 10.40 | 13 | 54093 | 718 | 29519703 |
Alveolitis | 17.85 | 10.40 | 18 | 54088 | 1558 | 29518863 |
Vomiting | 17.75 | 10.40 | 511 | 53595 | 211749 | 29308672 |
Drug intolerance | 17.57 | 10.40 | 39 | 54067 | 48340 | 29472081 |
Skin exfoliation | 17.53 | 10.40 | 85 | 54021 | 22560 | 29497861 |
Sense of oppression | 17.46 | 10.40 | 11 | 54095 | 480 | 29519941 |
Pharyngitis | 17.31 | 10.40 | 39 | 54067 | 6944 | 29513477 |
Exposure during pregnancy | 17.14 | 10.40 | 44 | 54062 | 8510 | 29511911 |
Haematoma muscle | 16.86 | 10.40 | 14 | 54092 | 943 | 29519478 |
Maple syrup disease | 16.84 | 10.40 | 4 | 54102 | 8 | 29520413 |
Dermatosis | 16.75 | 10.40 | 9 | 54097 | 290 | 29520131 |
Infusion site induration | 16.67 | 10.40 | 8 | 54098 | 202 | 29520219 |
Deep vein thrombosis | 16.49 | 10.40 | 52 | 54054 | 57347 | 29463074 |
Pharyngeal oedema | 16.48 | 10.40 | 34 | 54072 | 5700 | 29514721 |
Metastases to heart | 16.46 | 10.40 | 7 | 54099 | 132 | 29520289 |
Maternal exposure during pregnancy | 16.27 | 10.40 | 28 | 54078 | 4095 | 29516326 |
Blood creatine phosphokinase increased | 16.25 | 10.40 | 31 | 54075 | 40613 | 29479808 |
Accessory auricle | 16.23 | 10.40 | 4 | 54102 | 10 | 29520411 |
Exostosis of external ear canal | 16.23 | 10.40 | 4 | 54102 | 10 | 29520411 |
Odynophagia | 16.23 | 10.40 | 30 | 54076 | 4640 | 29515781 |
Coagulation factor decreased | 16.21 | 10.40 | 6 | 54100 | 77 | 29520344 |
Body fat disorder | 16.20 | 10.40 | 5 | 54101 | 35 | 29520386 |
Ileal perforation | 15.95 | 10.40 | 12 | 54094 | 700 | 29519721 |
Inflammatory marker increased | 15.93 | 10.40 | 26 | 54080 | 3641 | 29516780 |
Neutrophil count decreased | 15.92 | 10.40 | 35 | 54071 | 43532 | 29476889 |
Tonsillar erythema | 15.92 | 10.40 | 3 | 54103 | 0 | 29520421 |
Tongue discolouration | 15.86 | 10.40 | 14 | 54092 | 1025 | 29519396 |
Eye swelling | 15.79 | 10.40 | 43 | 54063 | 8614 | 29511807 |
Vesicoureteric reflux | 15.64 | 10.40 | 7 | 54099 | 150 | 29520271 |
Hypocoagulable state | 15.54 | 10.40 | 13 | 54093 | 885 | 29519536 |
Interstitial lung disease | 15.41 | 10.40 | 54 | 54052 | 57664 | 29462757 |
Cheilitis | 15.39 | 10.40 | 19 | 54087 | 2057 | 29518364 |
Morganella infection | 15.38 | 10.40 | 10 | 54096 | 461 | 29519960 |
Heart rate decreased | 15.06 | 10.40 | 14 | 54092 | 24898 | 29495523 |
Periostosis | 15.02 | 10.40 | 4 | 54102 | 15 | 29520406 |
Agranulocytosis | 14.79 | 10.40 | 75 | 54031 | 20265 | 29500156 |
Hepatitis | 14.67 | 10.40 | 76 | 54030 | 20707 | 29499714 |
Cardiac arrest | 14.65 | 10.40 | 94 | 54012 | 85497 | 29434924 |
Sepsis | 14.57 | 10.40 | 179 | 53927 | 142503 | 29377918 |
Spinal muscular atrophy | 14.32 | 10.40 | 8 | 54098 | 279 | 29520142 |
Balanoposthitis | 14.30 | 10.40 | 13 | 54093 | 989 | 29519432 |
Breath sounds | 14.26 | 10.40 | 4 | 54102 | 19 | 29520402 |
Liver function test abnormal | 14.12 | 10.40 | 96 | 54010 | 28822 | 29491599 |
Congenital heart valve disorder | 14.04 | 10.40 | 5 | 54101 | 57 | 29520364 |
Chest discomfort | 13.96 | 10.40 | 137 | 53969 | 45846 | 29474575 |
Infusion related reaction | 13.88 | 10.40 | 38 | 54068 | 43848 | 29476573 |
Encephalitis | 13.85 | 10.40 | 34 | 54072 | 6396 | 29514025 |
Constipation | 13.72 | 10.40 | 138 | 53968 | 114022 | 29406399 |
Chromaturia | 13.71 | 10.40 | 53 | 54053 | 12749 | 29507672 |
Infusion site swelling | 13.68 | 10.40 | 17 | 54089 | 1853 | 29518568 |
Lower respiratory tract infection | 13.56 | 10.40 | 89 | 54017 | 26413 | 29494008 |
Maternal drugs affecting foetus | 13.52 | 10.40 | 25 | 54081 | 3868 | 29516553 |
Dental caries | 13.47 | 10.40 | 26 | 54080 | 4154 | 29516267 |
Loss of personal independence in daily activities | 13.47 | 10.40 | 16 | 54090 | 25424 | 29494997 |
Crying | 13.39 | 10.40 | 30 | 54076 | 5321 | 29515100 |
Tongue eruption | 13.38 | 10.40 | 3 | 54103 | 4 | 29520417 |
Intentional product misuse | 13.37 | 10.40 | 27 | 54079 | 34634 | 29485787 |
Erythema annulare | 13.34 | 10.40 | 4 | 54102 | 25 | 29520396 |
Symmetrical drug-related intertriginous and flexural exanthema | 13.13 | 10.40 | 7 | 54099 | 222 | 29520199 |
Allergy test positive | 13.08 | 10.40 | 4 | 54102 | 27 | 29520394 |
Normocytic anaemia | 12.83 | 10.40 | 17 | 54089 | 1975 | 29518446 |
Chronic kidney disease | 12.82 | 10.40 | 112 | 53994 | 36304 | 29484117 |
Pleocytosis | 12.81 | 10.40 | 9 | 54097 | 472 | 29519949 |
Osteonecrosis of jaw | 12.80 | 10.40 | 62 | 54044 | 16448 | 29503973 |
Genital lesion | 12.77 | 10.40 | 7 | 54099 | 235 | 29520186 |
Haematocrit decreased | 12.63 | 10.40 | 21 | 54085 | 29001 | 29491420 |
Cerebral haemorrhage | 12.54 | 10.40 | 24 | 54082 | 31402 | 29489019 |
Ligament sprain | 12.39 | 10.40 | 20 | 54086 | 2775 | 29517646 |
Ischaemic stroke | 12.23 | 10.40 | 7 | 54099 | 15970 | 29504451 |
Product use in unapproved indication | 12.18 | 10.40 | 101 | 54005 | 86774 | 29433647 |
Substance-induced mood disorder | 12.13 | 10.40 | 5 | 54101 | 87 | 29520334 |
Bronchial haemorrhage | 12.05 | 10.40 | 10 | 54096 | 673 | 29519748 |
Factor V inhibition | 11.97 | 10.40 | 6 | 54100 | 167 | 29520254 |
Nephritis | 11.90 | 10.40 | 17 | 54089 | 2119 | 29518302 |
Pulmonary sequestration | 11.89 | 10.40 | 4 | 54102 | 38 | 29520383 |
Cyanosis neonatal | 11.79 | 10.40 | 7 | 54099 | 274 | 29520147 |
Helicobacter gastritis | 11.79 | 10.40 | 12 | 54094 | 1050 | 29519371 |
Gastrooesophageal reflux disease | 11.68 | 10.40 | 98 | 54008 | 31398 | 29489023 |
Blood pressure increased | 11.66 | 10.40 | 83 | 54023 | 73720 | 29446701 |
Gastritis | 11.52 | 10.40 | 68 | 54038 | 19449 | 29500972 |
Intervertebral disc degeneration | 11.52 | 10.40 | 28 | 54078 | 5236 | 29515185 |
Epstein-Barr virus antibody positive | 11.48 | 10.40 | 7 | 54099 | 288 | 29520133 |
Ear swelling | 11.46 | 10.40 | 8 | 54098 | 415 | 29520006 |
Senile dementia | 11.45 | 10.40 | 4 | 54102 | 43 | 29520378 |
Periodontal disease | 11.42 | 10.40 | 10 | 54096 | 724 | 29519697 |
Clostridium difficile infection | 11.37 | 10.40 | 59 | 54047 | 16082 | 29504339 |
Contraindicated product administered | 11.36 | 10.40 | 10 | 54096 | 18256 | 29502165 |
Biliary sepsis | 11.30 | 10.40 | 9 | 54097 | 571 | 29519850 |
Blood pressure systolic decreased | 11.29 | 10.40 | 23 | 54083 | 3821 | 29516600 |
Serum sickness | 11.27 | 10.40 | 15 | 54091 | 1750 | 29518671 |
Mental status changes | 11.23 | 10.40 | 30 | 54076 | 34897 | 29485524 |
Orthostatic hypotension | 11.18 | 10.40 | 15 | 54091 | 22614 | 29497807 |
Treatment failure | 10.94 | 10.40 | 33 | 54073 | 36906 | 29483515 |
Therapeutic product ineffective for unapproved indication | 10.92 | 10.40 | 3 | 54103 | 13 | 29520408 |
Dental care | 10.90 | 10.40 | 6 | 54100 | 203 | 29520218 |
Blister | 10.89 | 10.40 | 68 | 54038 | 19838 | 29500583 |
Patellofemoral pain syndrome | 10.89 | 10.40 | 5 | 54101 | 114 | 29520307 |
Alveolar proteinosis | 10.84 | 10.40 | 7 | 54099 | 319 | 29520102 |
Lymphadenitis | 10.79 | 10.40 | 14 | 54092 | 1593 | 29518828 |
Throat tightness | 10.79 | 10.40 | 33 | 54073 | 7058 | 29513363 |
Nasal neoplasm | 10.77 | 10.40 | 5 | 54101 | 117 | 29520304 |
Stoma closure | 10.77 | 10.40 | 5 | 54101 | 117 | 29520304 |
Abdominal pain upper | 10.76 | 10.40 | 164 | 53942 | 60829 | 29459592 |
Pseudomembranous colitis | 10.73 | 10.40 | 18 | 54088 | 2579 | 29517842 |
Otitis media acute | 10.72 | 10.40 | 8 | 54098 | 461 | 29519960 |
Non-cardiogenic pulmonary oedema | 10.69 | 10.40 | 9 | 54097 | 618 | 29519803 |
Abdominal wall haematoma | 10.65 | 10.40 | 14 | 54092 | 1613 | 29518808 |
Enamel anomaly | 10.65 | 10.40 | 5 | 54101 | 120 | 29520301 |
Myasthenia gravis | 10.65 | 10.40 | 20 | 54086 | 3131 | 29517290 |
Mycoplasma test positive | 10.62 | 10.40 | 5 | 54101 | 121 | 29520300 |
Tooth hypoplasia | 10.62 | 10.40 | 5 | 54101 | 121 | 29520300 |
Hyperleukocytosis | 10.60 | 10.40 | 14 | 54092 | 1621 | 29518800 |
Foetal distress syndrome | 10.57 | 10.40 | 11 | 54095 | 988 | 29519433 |
Product dose omission issue | 10.57 | 10.40 | 119 | 53987 | 96264 | 29424157 |
Binocular eye movement disorder | 10.56 | 10.40 | 4 | 54102 | 55 | 29520366 |
Ischaemic cerebral infarction | 10.52 | 10.40 | 11 | 54095 | 994 | 29519427 |
Resuscitation | 10.48 | 10.40 | 12 | 54094 | 1200 | 29519221 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pruritus | 837.52 | 9.73 | 1783 | 114865 | 310617 | 64071467 |
Drug reaction with eosinophilia and systemic symptoms | 791.32 | 9.73 | 708 | 115940 | 53509 | 64328575 |
Rash maculo-papular | 752.25 | 9.73 | 647 | 116001 | 46379 | 64335705 |
Urticaria | 744.91 | 9.73 | 1111 | 115537 | 146206 | 64235878 |
Anaphylactic shock | 640.87 | 9.73 | 491 | 116157 | 29837 | 64352247 |
Angioedema | 560.11 | 9.73 | 623 | 116025 | 61198 | 64320886 |
Rash | 510.25 | 9.73 | 1901 | 114747 | 456648 | 63925436 |
Erythema | 507.28 | 9.73 | 1074 | 115574 | 185996 | 64196088 |
Drug hypersensitivity | 448.54 | 9.73 | 1185 | 115463 | 236630 | 64145454 |
Cross sensitivity reaction | 435.78 | 9.73 | 180 | 116468 | 3187 | 64378897 |
Acute generalised exanthematous pustulosis | 424.67 | 9.73 | 283 | 116365 | 13775 | 64368309 |
Anaphylactic reaction | 377.16 | 9.73 | 539 | 116109 | 68125 | 64313959 |
Lip oedema | 376.06 | 9.73 | 185 | 116463 | 5004 | 64377080 |
Lip swelling | 359.01 | 9.73 | 361 | 116287 | 31546 | 64350538 |
Face oedema | 293.05 | 9.73 | 288 | 116360 | 24473 | 64357611 |
Type IV hypersensitivity reaction | 269.04 | 9.73 | 129 | 116519 | 3293 | 64378791 |
Eosinophilia | 250.01 | 9.73 | 326 | 116322 | 37750 | 64344334 |
Toxic skin eruption | 248.38 | 9.73 | 235 | 116413 | 19049 | 64363035 |
Type I hypersensitivity | 242.94 | 9.73 | 122 | 116526 | 3452 | 64378632 |
Hepatocellular injury | 240.86 | 9.73 | 350 | 116298 | 44885 | 64337199 |
Drug ineffective | 236.22 | 9.73 | 759 | 115889 | 839488 | 63542596 |
Crystalluria | 230.93 | 9.73 | 78 | 116570 | 760 | 64381324 |
Acute kidney injury | 229.30 | 9.73 | 1492 | 115156 | 447748 | 63934336 |
Completed suicide | 215.09 | 9.73 | 69 | 116579 | 224345 | 64157739 |
Death | 207.04 | 9.73 | 347 | 116301 | 482358 | 63899726 |
Wound closure | 205.18 | 9.73 | 50 | 116598 | 119 | 64381965 |
Swollen tongue | 204.61 | 9.73 | 283 | 116365 | 34671 | 64347413 |
Stevens-Johnson syndrome | 200.04 | 9.73 | 277 | 116371 | 33972 | 64348112 |
Swelling face | 197.58 | 9.73 | 371 | 116277 | 58795 | 64323289 |
Cholestasis | 192.25 | 9.73 | 314 | 116334 | 44558 | 64337526 |
Osteotomy | 192.09 | 9.73 | 50 | 116598 | 170 | 64381914 |
Meningitis aseptic | 191.71 | 9.73 | 123 | 116525 | 5607 | 64376477 |
Tongue oedema | 160.50 | 9.73 | 112 | 116536 | 5878 | 64376206 |
Toxic epidermal necrolysis | 160.45 | 9.73 | 261 | 116387 | 36905 | 64345179 |
Enterocolitis haemorrhagic | 156.74 | 9.73 | 75 | 116573 | 1905 | 64380179 |
Rash erythematous | 152.57 | 9.73 | 297 | 116351 | 48336 | 64333748 |
Rash pruritic | 147.64 | 9.73 | 323 | 116325 | 57081 | 64325003 |
Synovitis | 146.46 | 9.73 | 8 | 116640 | 99082 | 64283002 |
Tubulointerstitial nephritis | 144.34 | 9.73 | 225 | 116423 | 30684 | 64351400 |
Fall | 131.44 | 9.73 | 356 | 116292 | 416470 | 63965614 |
Rash macular | 122.76 | 9.73 | 181 | 116467 | 23504 | 64358580 |
Eyelid oedema | 116.71 | 9.73 | 127 | 116521 | 12152 | 64369932 |
Rash morbilliform | 114.64 | 9.73 | 86 | 116562 | 5055 | 64377029 |
Erythema multiforme | 113.41 | 9.73 | 141 | 116507 | 15560 | 64366524 |
Drug abuse | 109.69 | 9.73 | 51 | 116597 | 132323 | 64249761 |
Off label use | 106.21 | 9.73 | 690 | 115958 | 632116 | 63749968 |
Toxicity to various agents | 98.38 | 9.73 | 333 | 116315 | 363180 | 64018904 |
Jaundice | 97.54 | 9.73 | 248 | 116400 | 48264 | 64333820 |
Fatigue | 95.82 | 9.73 | 880 | 115768 | 747850 | 63634234 |
Infusion related reaction | 88.61 | 9.73 | 100 | 116548 | 164367 | 64217717 |
Dermatitis exfoliative generalised | 87.67 | 9.73 | 78 | 116570 | 5838 | 64376246 |
Rheumatoid arthritis | 85.17 | 9.73 | 103 | 116545 | 164191 | 64217893 |
Fixed eruption | 83.97 | 9.73 | 51 | 116597 | 2108 | 64379976 |
Cholecystitis chronic | 82.99 | 9.73 | 93 | 116555 | 9194 | 64372890 |
Therapeutic product effect decreased | 81.74 | 9.73 | 54 | 116594 | 115297 | 64266787 |
Hypersensitivity | 78.02 | 9.73 | 615 | 116033 | 195837 | 64186247 |
Kounis syndrome | 77.42 | 9.73 | 55 | 116593 | 2970 | 64379114 |
Hepatitis cholestatic | 75.02 | 9.73 | 101 | 116547 | 12054 | 64370030 |
Dermatitis allergic | 74.77 | 9.73 | 113 | 116535 | 14996 | 64367088 |
Hallucinations, mixed | 74.59 | 9.73 | 72 | 116576 | 5980 | 64376104 |
Pemphigus | 73.52 | 9.73 | 11 | 116637 | 60690 | 64321394 |
Malaise | 73.28 | 9.73 | 1063 | 115585 | 395184 | 63986900 |
Arthropathy | 72.59 | 9.73 | 67 | 116581 | 120900 | 64261184 |
Paraesthesia oral | 71.90 | 9.73 | 103 | 116545 | 13028 | 64369056 |
Clostridium difficile infection | 70.76 | 9.73 | 183 | 116465 | 35980 | 64346104 |
Hand deformity | 70.27 | 9.73 | 14 | 116634 | 62757 | 64319327 |
Drug eruption | 68.79 | 9.73 | 181 | 116467 | 35955 | 64346129 |
Injection site pain | 67.68 | 9.73 | 61 | 116587 | 111347 | 64270737 |
Periorbital oedema | 67.55 | 9.73 | 75 | 116573 | 7339 | 64374745 |
Laryngeal oedema | 66.61 | 9.73 | 73 | 116575 | 7040 | 64375044 |
Contraindicated product administered | 65.56 | 9.73 | 59 | 116589 | 107770 | 64274314 |
Febrile neutropenia | 63.84 | 9.73 | 154 | 116494 | 187503 | 64194581 |
Throat tightness | 63.75 | 9.73 | 134 | 116514 | 23026 | 64359058 |
Drug-induced liver injury | 62.42 | 9.73 | 209 | 116439 | 47434 | 64334650 |
Product use issue | 62.14 | 9.73 | 112 | 116536 | 151603 | 64230481 |
Bronchospasm | 61.50 | 9.73 | 127 | 116521 | 21555 | 64360529 |
Crystal nephropathy | 60.05 | 9.73 | 34 | 116614 | 1231 | 64380853 |
Systemic lupus erythematosus | 59.64 | 9.73 | 33 | 116615 | 77579 | 64304505 |
Alopecia | 58.74 | 9.73 | 133 | 116515 | 165557 | 64216527 |
Documented hypersensitivity to administered product | 57.79 | 9.73 | 29 | 116619 | 819 | 64381265 |
Purpura | 57.36 | 9.73 | 108 | 116540 | 17138 | 64364946 |
Vomiting | 56.84 | 9.73 | 1350 | 115298 | 549767 | 63832317 |
Wheezing | 56.76 | 9.73 | 292 | 116356 | 80287 | 64301797 |
Dental operation | 54.62 | 9.73 | 29 | 116619 | 923 | 64381161 |
Clostridium difficile colitis | 53.50 | 9.73 | 138 | 116510 | 27085 | 64354999 |
Arthralgia | 52.87 | 9.73 | 528 | 116120 | 441732 | 63940352 |
Wound | 52.57 | 9.73 | 37 | 116611 | 76440 | 64305644 |
Therapeutic product effect incomplete | 52.42 | 9.73 | 66 | 116582 | 103416 | 64278668 |
Pericarditis | 51.90 | 9.73 | 24 | 116624 | 62492 | 64319592 |
Drug intolerance | 50.23 | 9.73 | 173 | 116475 | 187819 | 64194265 |
Weight increased | 50.08 | 9.73 | 207 | 116441 | 213141 | 64168943 |
Hepatitis acute | 49.79 | 9.73 | 88 | 116560 | 13301 | 64368783 |
Diarrhoea | 48.87 | 9.73 | 1678 | 114970 | 721026 | 63661058 |
Malignant neoplasm progression | 48.33 | 9.73 | 81 | 116567 | 112790 | 64269294 |
Injection site erythema | 47.69 | 9.73 | 35 | 116613 | 70765 | 64311319 |
Tongue discolouration | 47.14 | 9.73 | 43 | 116605 | 3325 | 64378759 |
Cardiac failure congestive | 46.13 | 9.73 | 105 | 116543 | 130475 | 64251609 |
Dyspnoea | 45.44 | 9.73 | 1656 | 114992 | 717018 | 63665066 |
Duodenal ulcer perforation | 45.00 | 9.73 | 5 | 116643 | 34620 | 64347464 |
Agranulocytosis | 44.27 | 9.73 | 161 | 116487 | 38068 | 64344016 |
Mouth swelling | 43.69 | 9.73 | 50 | 116598 | 5057 | 64377027 |
Treatment failure | 43.68 | 9.73 | 91 | 116557 | 116725 | 64265359 |
Dermatitis bullous | 43.25 | 9.73 | 78 | 116570 | 11976 | 64370108 |
Acute hepatic failure | 42.96 | 9.73 | 124 | 116524 | 25988 | 64356096 |
Loss of personal independence in daily activities | 42.43 | 9.73 | 41 | 116607 | 72413 | 64309671 |
Pseudomembranous colitis | 41.83 | 9.73 | 48 | 116600 | 4868 | 64377216 |
Discomfort | 41.57 | 9.73 | 51 | 116597 | 80827 | 64301257 |
Skin test positive | 41.28 | 9.73 | 25 | 116623 | 1028 | 64381056 |
Emotional distress | 40.24 | 9.73 | 150 | 116498 | 35888 | 64346196 |
Bradycardia | 40.20 | 9.73 | 97 | 116551 | 118122 | 64263962 |
Injury | 40.19 | 9.73 | 204 | 116444 | 55788 | 64326296 |
Skin reaction | 39.41 | 9.73 | 76 | 116572 | 12276 | 64369808 |
Helicobacter test positive | 38.70 | 9.73 | 24 | 116624 | 1030 | 64381054 |
Joint swelling | 38.46 | 9.73 | 230 | 116418 | 215152 | 64166932 |
Hepatitis | 38.46 | 9.73 | 174 | 116474 | 45408 | 64336676 |
Hepatic cytolysis | 38.33 | 9.73 | 81 | 116567 | 13968 | 64368116 |
Palatal oedema | 38.33 | 9.73 | 25 | 116623 | 1172 | 64380912 |
Otospondylomegaepiphyseal dysplasia | 38.19 | 9.73 | 10 | 116638 | 35 | 64382049 |
Rash papular | 38.11 | 9.73 | 91 | 116557 | 17022 | 64365062 |
Acute psychosis | 37.75 | 9.73 | 40 | 116608 | 3712 | 64378372 |
Eczema | 37.71 | 9.73 | 129 | 116519 | 29591 | 64352493 |
Mixed liver injury | 37.63 | 9.73 | 48 | 116600 | 5433 | 64376651 |
Interstitial lung disease | 37.50 | 9.73 | 75 | 116573 | 97657 | 64284427 |
Basilar artery occlusion | 37.48 | 9.73 | 14 | 116634 | 187 | 64381897 |
Chromaturia | 36.83 | 9.73 | 107 | 116541 | 22504 | 64359580 |
Hyperleukocytosis | 36.56 | 9.73 | 30 | 116618 | 2010 | 64380074 |
Symmetrical drug-related intertriginous and flexural exanthema | 35.86 | 9.73 | 19 | 116629 | 602 | 64381482 |
Injection site swelling | 35.70 | 9.73 | 15 | 116633 | 41338 | 64340746 |
Platelet count decreased | 35.55 | 9.73 | 169 | 116479 | 167542 | 64214542 |
Glossodynia | 35.18 | 9.73 | 39 | 116609 | 64657 | 64317427 |
Ureteric compression | 35.05 | 9.73 | 13 | 116635 | 170 | 64381914 |
Jaundice cholestatic | 34.87 | 9.73 | 59 | 116589 | 8611 | 64373473 |
Skin candida | 34.70 | 9.73 | 27 | 116621 | 1676 | 64380408 |
Vascular purpura | 34.54 | 9.73 | 32 | 116616 | 2524 | 64379560 |
Lymphadenopathy | 34.14 | 9.73 | 171 | 116477 | 46515 | 64335569 |
Degenerative mitral valve disease | 34.14 | 9.73 | 14 | 116634 | 243 | 64381841 |
Macule | 34.00 | 9.73 | 31 | 116617 | 2395 | 64379689 |
Eye swelling | 33.98 | 9.73 | 103 | 116545 | 22178 | 64359906 |
Laryngeal discomfort | 33.81 | 9.73 | 17 | 116631 | 482 | 64381602 |
Myocardial infarction | 33.47 | 9.73 | 170 | 116478 | 165651 | 64216433 |
Anaemia | 33.37 | 9.73 | 483 | 116165 | 378197 | 64003887 |
Bone disorder | 32.97 | 9.73 | 85 | 116563 | 16674 | 64365410 |
Pharyngeal oedema | 32.89 | 9.73 | 81 | 116567 | 15450 | 64366634 |
Odynophagia | 32.84 | 9.73 | 61 | 116587 | 9580 | 64372504 |
Disease progression | 32.28 | 9.73 | 139 | 116509 | 141541 | 64240543 |
Serum sickness-like reaction | 32.25 | 9.73 | 17 | 116631 | 533 | 64381551 |
Biliary sepsis | 32.09 | 9.73 | 24 | 116624 | 1404 | 64380680 |
Abdominal pain | 31.42 | 9.73 | 763 | 115885 | 311612 | 64070472 |
Conjunctival irritation | 31.05 | 9.73 | 11 | 116637 | 125 | 64381959 |
Conjunctivitis | 30.95 | 9.73 | 94 | 116554 | 20260 | 64361824 |
Depressed level of consciousness | 29.97 | 9.73 | 64 | 116584 | 81372 | 64300712 |
Blood pressure increased | 29.89 | 9.73 | 186 | 116462 | 172366 | 64209718 |
Tooth infection | 29.71 | 9.73 | 75 | 116573 | 14526 | 64367558 |
Liver injury | 29.68 | 9.73 | 120 | 116528 | 29812 | 64352272 |
Tubulointerstitial nephritis and uveitis syndrome | 29.52 | 9.73 | 13 | 116635 | 271 | 64381813 |
Muscle injury | 29.37 | 9.73 | 6 | 116642 | 26431 | 64355653 |
Tongue coated | 29.31 | 9.73 | 21 | 116627 | 1149 | 64380935 |
Moraxella test positive | 29.23 | 9.73 | 7 | 116641 | 15 | 64382069 |
Impaired healing | 29.16 | 9.73 | 40 | 116608 | 60433 | 64321651 |
Rash pustular | 28.15 | 9.73 | 58 | 116590 | 9827 | 64372257 |
Intentional product use issue | 28.07 | 9.73 | 84 | 116564 | 95280 | 64286804 |
Cardiac failure | 27.69 | 9.73 | 134 | 116514 | 132239 | 64249845 |
Cheilitis | 27.69 | 9.73 | 38 | 116610 | 4618 | 64377466 |
Folliculitis | 27.47 | 9.73 | 10 | 116638 | 30067 | 64352017 |
Stomatitis | 27.18 | 9.73 | 104 | 116544 | 109501 | 64272583 |
Oral discomfort | 27.16 | 9.73 | 52 | 116596 | 8354 | 64373730 |
Allergy to chemicals | 26.87 | 9.73 | 19 | 116629 | 1018 | 64381066 |
Peritonsillar abscess | 26.73 | 9.73 | 17 | 116631 | 763 | 64381321 |
Henoch-Schonlein purpura | 26.73 | 9.73 | 26 | 116622 | 2180 | 64379904 |
Conjunctival hyperaemia | 26.54 | 9.73 | 34 | 116614 | 3865 | 64378219 |
Drug interaction | 26.46 | 9.73 | 849 | 115799 | 361234 | 64020850 |
Skin exfoliation | 26.45 | 9.73 | 155 | 116493 | 44730 | 64337354 |
Mobility decreased | 26.44 | 9.73 | 74 | 116574 | 85766 | 64296318 |
Malignant mesenteric neoplasm | 26.38 | 9.73 | 8 | 116640 | 53 | 64382031 |
Macroglossia | 26.31 | 9.73 | 19 | 116629 | 1053 | 64381031 |
Pain | 26.14 | 9.73 | 782 | 115866 | 552729 | 63829355 |
Somatic delusion | 26.07 | 9.73 | 16 | 116632 | 674 | 64381410 |
Injection site haemorrhage | 25.97 | 9.73 | 6 | 116642 | 24272 | 64357812 |
Liver function test abnormal | 25.80 | 9.73 | 190 | 116458 | 59211 | 64322873 |
SJS-TEN overlap | 25.77 | 9.73 | 14 | 116634 | 467 | 64381617 |
Tinnitus | 25.65 | 9.73 | 126 | 116522 | 34007 | 64348077 |
Lip erosion | 25.46 | 9.73 | 20 | 116628 | 1259 | 64380825 |
Salpingo-oophorectomy unilateral | 25.37 | 9.73 | 14 | 116634 | 482 | 64381602 |
Swelling of eyelid | 25.01 | 9.73 | 25 | 116623 | 2167 | 64379917 |
Hepatic ischaemia | 24.82 | 9.73 | 18 | 116630 | 1004 | 64381080 |
Muscle relaxant therapy | 24.79 | 9.73 | 10 | 116638 | 166 | 64381918 |
Ventricular enlargement | 24.67 | 9.73 | 14 | 116634 | 509 | 64381575 |
Secondary amyloidosis | 24.38 | 9.73 | 9 | 116639 | 116 | 64381968 |
Lymphadenitis | 24.20 | 9.73 | 32 | 116616 | 3753 | 64378331 |
Abdominal discomfort | 24.15 | 9.73 | 212 | 116436 | 182110 | 64199974 |
Pain in extremity | 24.15 | 9.73 | 394 | 116254 | 302691 | 64079393 |
General physical health deterioration | 23.97 | 9.73 | 245 | 116403 | 204180 | 64177904 |
Therapeutic response decreased | 23.70 | 9.73 | 36 | 116612 | 52152 | 64329932 |
Thermal burn | 23.50 | 9.73 | 40 | 116608 | 5866 | 64376218 |
Rash vesicular | 23.27 | 9.73 | 36 | 116612 | 4874 | 64377210 |
Pyelocaliectasis | 23.23 | 9.73 | 16 | 116632 | 822 | 64381262 |
Pyrexia | 23.13 | 9.73 | 1233 | 115415 | 557411 | 63824673 |
Dermatitis exfoliative | 23.00 | 9.73 | 55 | 116593 | 10297 | 64371787 |
Knee arthroplasty | 22.98 | 9.73 | 10 | 116638 | 26989 | 64355095 |
Chronic sinusitis | 22.94 | 9.73 | 41 | 116607 | 6251 | 64375833 |
Factitious disorder | 22.91 | 9.73 | 9 | 116639 | 139 | 64381945 |
Oral mucosal blistering | 22.89 | 9.73 | 37 | 116611 | 5200 | 64376884 |
Penile erythema | 22.85 | 9.73 | 9 | 116639 | 140 | 64381944 |
Inferior vena cava dilatation | 22.33 | 9.73 | 15 | 116633 | 739 | 64381345 |
Product dose omission issue | 22.18 | 9.73 | 235 | 116413 | 194512 | 64187572 |
Multiple sclerosis relapse | 22.14 | 9.73 | 25 | 116623 | 41110 | 64340974 |
Rash scarlatiniform | 21.97 | 9.73 | 10 | 116638 | 226 | 64381858 |
Fluid retention | 21.80 | 9.73 | 47 | 116601 | 59559 | 64322525 |
Medication error | 21.80 | 9.73 | 160 | 116488 | 49806 | 64332278 |
Pulmonary vascular disorder | 21.74 | 9.73 | 16 | 116632 | 913 | 64381171 |
Mental status changes | 21.73 | 9.73 | 49 | 116599 | 61113 | 64320971 |
Normal tension glaucoma | 21.62 | 9.73 | 7 | 116641 | 59 | 64382025 |
Breast cancer | 21.52 | 9.73 | 13 | 116635 | 29135 | 64352949 |
Injection site pruritus | 21.46 | 9.73 | 22 | 116626 | 37804 | 64344280 |
Orthostatic hypotension | 21.46 | 9.73 | 32 | 116616 | 46706 | 64335378 |
Nasopharyngitis | 21.37 | 9.73 | 239 | 116409 | 195834 | 64186250 |
Cardiac arrest | 21.36 | 9.73 | 177 | 116471 | 153887 | 64228197 |
Nicotine dependence | 21.29 | 9.73 | 15 | 116633 | 799 | 64381285 |
Musculoskeletal stiffness | 21.23 | 9.73 | 133 | 116515 | 123073 | 64259011 |
Oedema | 21.22 | 9.73 | 257 | 116391 | 91678 | 64290406 |
Jejunal ulcer perforation | 21.21 | 9.73 | 8 | 116640 | 110 | 64381974 |
Flank pain | 21.18 | 9.73 | 71 | 116577 | 16118 | 64365966 |
White blood cell count decreased | 21.14 | 9.73 | 183 | 116465 | 157654 | 64224430 |
Pleural effusion | 21.10 | 9.73 | 138 | 116510 | 126421 | 64255663 |
Intentional product misuse | 21.05 | 9.73 | 64 | 116584 | 72231 | 64309853 |
Cell death | 21.03 | 9.73 | 31 | 116617 | 4023 | 64378061 |
Laryngeal dyspnoea | 20.93 | 9.73 | 10 | 116638 | 253 | 64381831 |
Urinary tract infection | 20.86 | 9.73 | 294 | 116354 | 231302 | 64150782 |
International normalised ratio increased | 20.83 | 9.73 | 227 | 116421 | 78940 | 64303144 |
Influenza B virus test positive | 20.72 | 9.73 | 11 | 116637 | 350 | 64381734 |
Hyperaemia | 20.65 | 9.73 | 25 | 116623 | 2684 | 64379400 |
Sputum increased | 20.62 | 9.73 | 29 | 116619 | 3606 | 64378478 |
Osteonecrosis of jaw | 20.62 | 9.73 | 133 | 116515 | 39692 | 64342392 |
Sedation | 20.42 | 9.73 | 27 | 116621 | 41435 | 64340649 |
Pharyngitis | 20.22 | 9.73 | 78 | 116570 | 18961 | 64363123 |
Eastern Cooperative Oncology Group performance status | 20.15 | 9.73 | 6 | 116642 | 37 | 64382047 |
Faeces pale | 20.04 | 9.73 | 24 | 116624 | 2547 | 64379537 |
Pharyngeal swelling | 19.98 | 9.73 | 36 | 116612 | 5523 | 64376561 |
Gallbladder disorder | 19.95 | 9.73 | 72 | 116576 | 16958 | 64365126 |
Ureteral disorder | 19.82 | 9.73 | 12 | 116636 | 493 | 64381591 |
Haemolytic anaemia | 19.77 | 9.73 | 69 | 116579 | 15984 | 64366100 |
Pulmonary artery stenosis congenital | 19.68 | 9.73 | 5 | 116643 | 15 | 64382069 |
Prothrombin time ratio decreased | 19.66 | 9.73 | 14 | 116634 | 759 | 64381325 |
Inappropriate schedule of product administration | 19.54 | 9.73 | 93 | 116555 | 92193 | 64289891 |
Infective exacerbation of chronic obstructive airways disease | 19.40 | 9.73 | 23 | 116625 | 2415 | 64379669 |
Device expulsion | 19.35 | 9.73 | 7 | 116641 | 21129 | 64360955 |
Vanishing bile duct syndrome | 19.25 | 9.73 | 17 | 116631 | 1260 | 64380824 |
Omental necrosis | 19.14 | 9.73 | 6 | 116642 | 45 | 64382039 |
Nephritis | 19.09 | 9.73 | 28 | 116620 | 3618 | 64378466 |
Localised oedema | 19.09 | 9.73 | 41 | 116607 | 7150 | 64374934 |
Neutropenic sepsis | 19.00 | 9.73 | 88 | 116560 | 23184 | 64358900 |
Cardiac aneurysm | 19.00 | 9.73 | 17 | 116631 | 1282 | 64380802 |
Serum sickness | 18.92 | 9.73 | 26 | 116622 | 3163 | 64378921 |
Oxygen saturation decreased | 18.82 | 9.73 | 115 | 116533 | 107061 | 64275023 |
Dysphonia | 18.81 | 9.73 | 146 | 116502 | 46236 | 64335848 |
Sensation of foreign body | 18.69 | 9.73 | 31 | 116617 | 4451 | 64377633 |
Abnormal faeces | 18.63 | 9.73 | 36 | 116612 | 5823 | 64376261 |
Sinusitis fungal | 18.62 | 9.73 | 19 | 116629 | 1687 | 64380397 |
Visual snow syndrome | 18.57 | 9.73 | 5 | 116643 | 20 | 64382064 |
Plica syndrome | 18.50 | 9.73 | 4 | 116644 | 4 | 64382080 |
Myelosuppression | 18.49 | 9.73 | 10 | 116638 | 23820 | 64358264 |
Ill-defined disorder | 18.49 | 9.73 | 32 | 116616 | 44020 | 64338064 |
Choluria | 18.31 | 9.73 | 10 | 116638 | 337 | 64381747 |
Abdominal wall haematoma | 18.26 | 9.73 | 30 | 116618 | 4275 | 64377809 |
Right ventricular failure | 18.20 | 9.73 | 8 | 116640 | 21463 | 64360621 |
Tryptase increased | 18.19 | 9.73 | 11 | 116637 | 451 | 64381633 |
Pharyngeal erythema | 18.14 | 9.73 | 19 | 116629 | 1740 | 64380344 |
Prothrombin time shortened | 18.08 | 9.73 | 24 | 116624 | 2825 | 64379259 |
Blood pressure fluctuation | 18.07 | 9.73 | 42 | 116606 | 51829 | 64330255 |
Chronic kidney disease | 18.07 | 9.73 | 172 | 116476 | 57747 | 64324337 |
Cerebral infarction | 17.98 | 9.73 | 29 | 116619 | 41015 | 64341069 |
Red blood cell sedimentation rate increased | 17.91 | 9.73 | 18 | 116630 | 31217 | 64350867 |
Mouth ulceration | 17.82 | 9.73 | 110 | 116538 | 32334 | 64349750 |
Tooth disorder | 17.77 | 9.73 | 84 | 116564 | 22318 | 64359766 |
Attention-seeking behaviour | 17.76 | 9.73 | 7 | 116641 | 109 | 64381975 |
Device malfunction | 17.63 | 9.73 | 5 | 116643 | 17628 | 64364456 |
Peripheral swelling | 17.62 | 9.73 | 269 | 116379 | 208884 | 64173200 |
Cardio-respiratory arrest | 17.58 | 9.73 | 105 | 116543 | 98288 | 64283796 |
Pharyngotonsillitis | 17.47 | 9.73 | 9 | 116639 | 269 | 64381815 |
Excessive eye blinking | 17.46 | 9.73 | 16 | 116632 | 1244 | 64380840 |
Ultrasound liver abnormal | 17.45 | 9.73 | 8 | 116640 | 184 | 64381900 |
Lip pain | 17.35 | 9.73 | 19 | 116629 | 1830 | 64380254 |
Otitis media acute | 17.22 | 9.73 | 15 | 116633 | 1091 | 64380993 |
Feeling hot | 17.03 | 9.73 | 141 | 116507 | 45522 | 64336562 |
Maple syrup disease | 16.89 | 9.73 | 4 | 116644 | 8 | 64382076 |
Psoriatic arthropathy | 16.78 | 9.73 | 33 | 116615 | 43248 | 64338836 |
Inflammatory marker increased | 16.77 | 9.73 | 43 | 116605 | 8408 | 64373676 |
Irritable bowel syndrome | 16.75 | 9.73 | 26 | 116622 | 37343 | 64344741 |
Small intestinal obstruction | 16.74 | 9.73 | 11 | 116637 | 23562 | 64358522 |
Hypersensitivity myocarditis | 16.72 | 9.73 | 6 | 116642 | 71 | 64382013 |
Hepatic necrosis | 16.69 | 9.73 | 43 | 116605 | 8430 | 64373654 |
Injection site rash | 16.62 | 9.73 | 4 | 116644 | 15738 | 64366346 |
Jarisch-Herxheimer reaction | 16.46 | 9.73 | 12 | 116636 | 675 | 64381409 |
Bipolar I disorder | 16.28 | 9.73 | 18 | 116630 | 1753 | 64380331 |
Exostosis of external ear canal | 16.28 | 9.73 | 4 | 116644 | 10 | 64382074 |
Genital erythema | 16.24 | 9.73 | 8 | 116640 | 217 | 64381867 |
Urinary retention | 16.22 | 9.73 | 41 | 116607 | 49160 | 64332924 |
Haematuria | 16.18 | 9.73 | 174 | 116474 | 60297 | 64321787 |
Acute respiratory failure | 16.16 | 9.73 | 42 | 116606 | 49892 | 64332192 |
Pneumopericardium | 16.07 | 9.73 | 7 | 116641 | 142 | 64381942 |
Gait disturbance | 16.05 | 9.73 | 217 | 116431 | 171938 | 64210146 |
Neuroleptic malignant syndrome | 16.01 | 9.73 | 13 | 116635 | 24983 | 64357101 |
Melanocytic hyperplasia | 16.00 | 9.73 | 4 | 116644 | 11 | 64382073 |
Disseminated intravascular coagulation | 15.99 | 9.73 | 21 | 116627 | 32327 | 64349757 |
Underdose | 15.85 | 9.73 | 14 | 116634 | 25815 | 64356269 |
Blood glucose increased | 15.81 | 9.73 | 108 | 116540 | 97965 | 64284119 |
Drug withdrawal syndrome | 15.79 | 9.73 | 20 | 116628 | 31271 | 64350813 |
Contusion | 15.76 | 9.73 | 131 | 116517 | 113834 | 64268250 |
Hypertransaminasaemia | 15.75 | 9.73 | 38 | 116610 | 7153 | 64374931 |
Toothache | 15.75 | 9.73 | 68 | 116580 | 17391 | 64364693 |
Tongue eruption | 15.74 | 9.73 | 6 | 116642 | 85 | 64381999 |
Dysentery | 15.74 | 9.73 | 13 | 116635 | 879 | 64381205 |
Palatal swelling | 15.72 | 9.73 | 7 | 116641 | 150 | 64381934 |
Candida infection | 15.70 | 9.73 | 104 | 116544 | 31315 | 64350769 |
Hepatic failure | 15.58 | 9.73 | 161 | 116487 | 55233 | 64326851 |
Premature baby | 15.52 | 9.73 | 24 | 116624 | 3248 | 64378836 |
Encephalitis | 15.45 | 9.73 | 54 | 116594 | 12517 | 64369567 |
Body fat disorder | 15.43 | 9.73 | 7 | 116641 | 157 | 64381927 |
Therapy non-responder | 15.40 | 9.73 | 64 | 116584 | 65835 | 64316249 |
Fear-related avoidance of activities | 15.37 | 9.73 | 6 | 116642 | 91 | 64381993 |
Accidental exposure to product | 15.34 | 9.73 | 15 | 116633 | 26349 | 64355735 |
Polymenorrhagia | 15.25 | 9.73 | 5 | 116643 | 44 | 64382040 |
Neoplasm progression | 15.23 | 9.73 | 32 | 116616 | 40932 | 64341152 |
Metastases to stomach | 15.20 | 9.73 | 8 | 116640 | 250 | 64381834 |
Condition aggravated | 15.19 | 9.73 | 536 | 116112 | 371890 | 64010194 |
Actinomycosis | 15.12 | 9.73 | 13 | 116635 | 929 | 64381155 |
Pharyngeal paraesthesia | 15.12 | 9.73 | 18 | 116630 | 1899 | 64380185 |
Incorrect route of product administration | 15.07 | 9.73 | 12 | 116636 | 23286 | 64358798 |
Periostosis | 15.06 | 9.73 | 4 | 116644 | 15 | 64382069 |
Foot fracture | 15.02 | 9.73 | 7 | 116641 | 18150 | 64363934 |
Dysphagia | 14.98 | 9.73 | 274 | 116374 | 106538 | 64275546 |
Genital erosion | 14.97 | 9.73 | 9 | 116639 | 365 | 64381719 |
Chest discomfort | 14.96 | 9.73 | 294 | 116354 | 115812 | 64266272 |
Ear swelling | 14.91 | 9.73 | 15 | 116633 | 1310 | 64380774 |
Hypertension | 14.89 | 9.73 | 356 | 116292 | 258905 | 64123179 |
PRIDE syndrome | 14.86 | 9.73 | 4 | 116644 | 16 | 64382068 |
Tooth discolouration | 14.85 | 9.73 | 13 | 116635 | 952 | 64381132 |
Dermatosis | 14.83 | 9.73 | 10 | 116638 | 496 | 64381588 |
Balanoposthitis | 14.78 | 9.73 | 12 | 116636 | 792 | 64381292 |
Cytomegalovirus infection | 14.74 | 9.73 | 28 | 116620 | 37171 | 64344913 |
Diabetes mellitus | 14.66 | 9.73 | 66 | 116582 | 66408 | 64315676 |
Adverse event | 14.55 | 9.73 | 31 | 116617 | 39458 | 64342626 |
Poisoning | 14.49 | 9.73 | 11 | 116637 | 21868 | 64360216 |
Myasthenia gravis | 14.42 | 9.73 | 32 | 116616 | 5706 | 64376378 |
Staphylococcal scalded skin syndrome | 14.41 | 9.73 | 9 | 116639 | 391 | 64381693 |
Crepitations | 14.41 | 9.73 | 39 | 116609 | 7876 | 64374208 |
Fracture | 14.37 | 9.73 | 8 | 116640 | 18747 | 64363337 |
Femoral artery embolism | 14.34 | 9.73 | 5 | 116643 | 54 | 64382030 |
Sebaceous gland infection | 14.33 | 9.73 | 6 | 116642 | 110 | 64381974 |
Hepatic enzyme increased | 14.30 | 9.73 | 158 | 116490 | 129785 | 64252299 |
Palpitations | 14.29 | 9.73 | 267 | 116381 | 104221 | 64277863 |
Spinal muscular atrophy | 14.22 | 9.73 | 8 | 116640 | 286 | 64381798 |
Substance-induced mood disorder | 14.18 | 9.73 | 6 | 116642 | 113 | 64381971 |
Enamel anomaly | 14.13 | 9.73 | 6 | 116642 | 114 | 64381970 |
Skin swelling | 14.13 | 9.73 | 21 | 116627 | 2745 | 64379339 |
Pruritus genital | 14.10 | 9.73 | 13 | 116635 | 1019 | 64381065 |
Eye injury | 14.06 | 9.73 | 16 | 116632 | 1608 | 64380476 |
Wrong technique in product usage process | 14.03 | 9.73 | 65 | 116583 | 64909 | 64317175 |
Full blood count abnormal | 14.02 | 9.73 | 20 | 116628 | 29737 | 64352347 |
Caffeine allergy | 13.98 | 9.73 | 4 | 116644 | 21 | 64382063 |
Forced vital capacity abnormal | 13.98 | 9.73 | 4 | 116644 | 21 | 64382063 |
Labile blood pressure | 13.94 | 9.73 | 18 | 116630 | 2062 | 64380022 |
Cognitive disorder | 13.83 | 9.73 | 52 | 116596 | 55035 | 64327049 |
Delayed delivery | 13.67 | 9.73 | 4 | 116644 | 23 | 64382061 |
Ileal perforation | 13.65 | 9.73 | 12 | 116636 | 884 | 64381200 |
Gamma-glutamyltransferase increased | 13.65 | 9.73 | 141 | 116507 | 48369 | 64333715 |
Pseudomyopia | 13.58 | 9.73 | 5 | 116643 | 64 | 64382020 |
Serotonin syndrome | 13.53 | 9.73 | 32 | 116616 | 39250 | 64342834 |
Gastritis | 13.51 | 9.73 | 127 | 116521 | 42491 | 64339593 |
Overdose | 13.51 | 9.73 | 205 | 116443 | 159361 | 64222723 |
Enanthema | 13.50 | 9.73 | 11 | 116637 | 730 | 64381354 |
Pneumonia | 13.49 | 9.73 | 852 | 115796 | 558724 | 63823360 |
Posterior reversible encephalopathy syndrome | 13.41 | 9.73 | 13 | 116635 | 22933 | 64359151 |
Coma | 13.38 | 9.73 | 98 | 116550 | 87517 | 64294567 |
Papule | 13.32 | 9.73 | 33 | 116615 | 6317 | 64375767 |
Cholestasis of pregnancy | 13.32 | 9.73 | 12 | 116636 | 913 | 64381171 |
Eosinophils urine present | 13.30 | 9.73 | 5 | 116643 | 68 | 64382016 |
Sepsis | 13.30 | 9.73 | 316 | 116332 | 230025 | 64152059 |
Sensitisation | 13.23 | 9.73 | 16 | 116632 | 1715 | 64380369 |
Infectious mononucleosis | 13.22 | 9.73 | 16 | 116632 | 1717 | 64380367 |
Fibromyalgia | 13.21 | 9.73 | 28 | 116620 | 35703 | 64346381 |
Injection site warmth | 13.12 | 9.73 | 4 | 116644 | 13458 | 64368626 |
Injection site reaction | 13.09 | 9.73 | 42 | 116606 | 46622 | 64335462 |
Pneumonia mycoplasmal | 13.01 | 9.73 | 14 | 116634 | 1322 | 64380762 |
Dyspnoea exertional | 13.00 | 9.73 | 79 | 116569 | 73651 | 64308433 |
Musculoskeletal pain | 12.87 | 9.73 | 90 | 116558 | 81204 | 64300880 |
Budd-Chiari syndrome | 12.86 | 9.73 | 5 | 116643 | 75 | 64382009 |
Asthenia | 12.82 | 9.73 | 638 | 116010 | 427406 | 63954678 |
Tongue pruritus | 12.78 | 9.73 | 9 | 116639 | 479 | 64381605 |
Somnolence | 12.71 | 9.73 | 276 | 116372 | 203369 | 64178715 |
Linear IgA disease | 12.68 | 9.73 | 20 | 116628 | 2754 | 64379330 |
Respiratory arrest | 12.67 | 9.73 | 51 | 116597 | 52934 | 64329150 |
Ear infection | 12.63 | 9.73 | 79 | 116569 | 23325 | 64358759 |
Oropharyngeal discomfort | 12.56 | 9.73 | 29 | 116619 | 5306 | 64376778 |
Anaphylactoid reaction | 12.56 | 9.73 | 27 | 116621 | 4711 | 64377373 |
Electrocardiogram QT prolonged | 12.55 | 9.73 | 88 | 116560 | 79360 | 64302724 |
Transplant rejection | 12.52 | 9.73 | 8 | 116640 | 17393 | 64364691 |
Drug dependence | 12.40 | 9.73 | 26 | 116622 | 33286 | 64348798 |
Coagulation factor decreased | 12.37 | 9.73 | 6 | 116642 | 157 | 64381927 |
Vasculitis | 12.34 | 9.73 | 65 | 116583 | 18030 | 64364054 |
Progressive multifocal leukoencephalopathy | 12.29 | 9.73 | 9 | 116639 | 18223 | 64363861 |
Atrial septal defect | 12.18 | 9.73 | 15 | 116633 | 1638 | 64380446 |
Bone erosion | 12.14 | 9.73 | 3 | 116645 | 11592 | 64370492 |
Biliary dyskinesia | 12.11 | 9.73 | 18 | 116630 | 2354 | 64379730 |
Metastases to central nervous system | 12.08 | 9.73 | 5 | 116643 | 13907 | 64368177 |
Glomerulonephritis acute | 12.07 | 9.73 | 6 | 116642 | 166 | 64381918 |
Glycosylated haemoglobin increased | 12.03 | 9.73 | 7 | 116641 | 16012 | 64366072 |
Pulmonary arterial hypertension | 12.00 | 9.73 | 17 | 116631 | 25350 | 64356734 |
Biliary colic | 11.99 | 9.73 | 22 | 116626 | 3422 | 64378662 |
Blood alkaline phosphatase increased | 11.99 | 9.73 | 155 | 116493 | 56124 | 64325960 |
Pericardial effusion | 11.97 | 9.73 | 34 | 116614 | 39220 | 64342864 |
Hypoaesthesia oral | 11.94 | 9.73 | 47 | 116601 | 11533 | 64370551 |
Abdominal pain upper | 11.88 | 9.73 | 407 | 116241 | 174623 | 64207461 |
Personal relationship issue | 11.84 | 9.73 | 6 | 116642 | 173 | 64381911 |
Pneumonia aspiration | 11.81 | 9.73 | 61 | 116587 | 59210 | 64322874 |
Transaminases increased | 11.78 | 9.73 | 128 | 116520 | 44466 | 64337618 |
Rectal polyp | 11.72 | 9.73 | 13 | 116635 | 1271 | 64380813 |
Cerebral haemorrhage | 11.70 | 9.73 | 50 | 116598 | 51040 | 64331044 |
Respiratory failure | 11.70 | 9.73 | 213 | 116435 | 160970 | 64221114 |
Lung neoplasm malignant | 11.58 | 9.73 | 13 | 116635 | 21435 | 64360649 |
Respiratory tract oedema | 11.57 | 9.73 | 10 | 116638 | 720 | 64381364 |
Hyperglycaemia | 11.46 | 9.73 | 64 | 116584 | 60904 | 64321180 |
Allergy test positive | 11.33 | 9.73 | 8 | 116640 | 428 | 64381656 |
Tendon disorder | 11.33 | 9.73 | 31 | 116617 | 6301 | 64375783 |
Subarachnoid haemorrhage | 11.31 | 9.73 | 10 | 116638 | 18428 | 64363656 |
Analgesic drug level increased | 11.26 | 9.73 | 17 | 116631 | 2253 | 64379831 |
Mucosal discolouration | 11.21 | 9.73 | 10 | 116638 | 751 | 64381333 |
Post-traumatic stress disorder | 11.19 | 9.73 | 24 | 116624 | 4181 | 64377903 |
Chapped lips | 11.18 | 9.73 | 16 | 116632 | 2022 | 64380062 |
Osteogenesis imperfecta | 11.13 | 9.73 | 6 | 116642 | 197 | 64381887 |
Lymphocytosis | 11.11 | 9.73 | 22 | 116626 | 3622 | 64378462 |
Mycoplasma test positive | 10.97 | 9.73 | 6 | 116642 | 203 | 64381881 |
Product complaint | 10.87 | 9.73 | 4 | 116644 | 11950 | 64370134 |
Epigastric discomfort | 10.87 | 9.73 | 32 | 116616 | 6779 | 64375305 |
Arthritis | 10.85 | 9.73 | 98 | 116550 | 83716 | 64298368 |
Femur fracture | 10.83 | 9.73 | 29 | 116619 | 34106 | 64347978 |
Acquired haemophilia | 10.83 | 9.73 | 14 | 116634 | 1606 | 64380478 |
Erythema nodosum | 10.82 | 9.73 | 23 | 116625 | 3981 | 64378103 |
Bleeding time prolonged | 10.81 | 9.73 | 12 | 116636 | 1174 | 64380910 |
Pharyngeal abscess | 10.79 | 9.73 | 9 | 116639 | 617 | 64381467 |
Tonsillar erythema | 10.77 | 9.73 | 3 | 116645 | 14 | 64382070 |
Prescribed underdose | 10.77 | 9.73 | 10 | 116638 | 18005 | 64364079 |
Electric shock sensation | 10.72 | 9.73 | 7 | 116641 | 329 | 64381755 |
Periorbital swelling | 10.69 | 9.73 | 15 | 116633 | 1861 | 64380223 |
Tongue dry | 10.67 | 9.73 | 11 | 116637 | 989 | 64381095 |
Intestinal obstruction | 10.65 | 9.73 | 32 | 116616 | 36254 | 64345830 |
Nail dystrophy | 10.64 | 9.73 | 10 | 116638 | 803 | 64381281 |
Allergy test negative | 10.60 | 9.73 | 3 | 116645 | 15 | 64382069 |
Lower gastrointestinal haemorrhage | 10.60 | 9.73 | 6 | 116642 | 13933 | 64368151 |
Systolic dysfunction | 10.58 | 9.73 | 20 | 116628 | 3182 | 64378902 |
Female genital tract fistula | 10.57 | 9.73 | 18 | 116630 | 2640 | 64379444 |
Prurigo | 10.55 | 9.73 | 12 | 116636 | 1205 | 64380879 |
Target skin lesion | 10.52 | 9.73 | 5 | 116643 | 125 | 64381959 |
Genital cyst | 10.47 | 9.73 | 4 | 116644 | 57 | 64382027 |
Metastases to heart | 10.43 | 9.73 | 6 | 116642 | 224 | 64381860 |
Psychotic behaviour | 10.41 | 9.73 | 11 | 116637 | 1018 | 64381066 |
Colon cancer | 10.40 | 9.73 | 5 | 116643 | 12734 | 64369350 |
Genital lesion | 10.37 | 9.73 | 8 | 116640 | 490 | 64381594 |
Stoma closure | 10.27 | 9.73 | 5 | 116643 | 132 | 64381952 |
Iris transillumination defect | 10.24 | 9.73 | 5 | 116643 | 133 | 64381951 |
Tonsillitis streptococcal | 10.17 | 9.73 | 5 | 116643 | 135 | 64381949 |
Ascites | 10.13 | 9.73 | 68 | 116580 | 61933 | 64320151 |
Acute febrile neutrophilic dermatosis | 10.03 | 9.73 | 20 | 116628 | 3309 | 64378775 |
Bone pain | 10.03 | 9.73 | 48 | 116600 | 47524 | 64334560 |
Gait inability | 9.99 | 9.73 | 41 | 116607 | 42327 | 64339757 |
Klebsiella infection | 9.96 | 9.73 | 49 | 116599 | 13232 | 64368852 |
Tonsillitis | 9.92 | 9.73 | 28 | 116620 | 5792 | 64376292 |
Clostridium colitis | 9.91 | 9.73 | 17 | 116631 | 2508 | 64379576 |
Tonsillar hypertrophy | 9.90 | 9.73 | 12 | 116636 | 1289 | 64380795 |
Eosinophilic pneumonia acute | 9.90 | 9.73 | 10 | 116638 | 877 | 64381207 |
Pneumococcal sepsis | 9.88 | 9.73 | 12 | 116636 | 1292 | 64380792 |
COVID-19 | 9.88 | 9.73 | 73 | 116575 | 65067 | 64317017 |
Creatinine renal clearance decreased | 9.88 | 9.73 | 7 | 116641 | 14414 | 64367670 |
Myelodysplastic syndrome | 9.87 | 9.73 | 22 | 116626 | 27557 | 64354527 |
Dermatomyositis | 9.87 | 9.73 | 18 | 116630 | 2788 | 64379296 |
Injection site mass | 9.85 | 9.73 | 10 | 116638 | 17260 | 64364824 |
Second primary malignancy | 9.84 | 9.73 | 5 | 116643 | 12332 | 64369752 |
Fibrous histiocytoma | 9.82 | 9.73 | 8 | 116640 | 531 | 64381553 |
Pulmonary oedema | 9.75 | 9.73 | 93 | 116555 | 78581 | 64303503 |
None
Source | Code | Description |
---|---|---|
ATC | A02BD01 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD03 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD04 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD05 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD06 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD07 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD10 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD11 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD12 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD13 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD14 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD15 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD16 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | J01CA04 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Penicillins with extended spectrum |
ATC | J01CR02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Combinations of penicillins, incl. beta-lactamase inhibitors |
FDA CS | M0016152 | Penicillins |
FDA EPC | N0000175497 | Penicillin-class Antibacterial |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute otitis media | indication | 3110003 | |
Staphylococcal tonsillitis | indication | 11461005 | |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Streptococcal tonsillitis | indication | 41582007 | |
Lower respiratory tract infection | indication | 50417007 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Klebsiella cystitis | indication | 60867007 | |
Pneumonia due to Klebsiella pneumoniae | indication | 64479007 | |
Urinary tract infectious disease | indication | 68566005 | |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Infection due to Escherichia coli | indication | 71057007 | |
Rhinoscleroma | indication | 72409005 | DOID:11336 |
Acute bacterial sinusitis | indication | 75498004 | |
Staphylococcal pharyngitis | indication | 82228008 | |
Pneumococcal pneumonia | indication | 233607000 | |
Escherichia coli urinary tract infection | indication | 301011002 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Bacterial urinary infection | indication | 312124009 | |
Infective otitis media | indication | 312218008 | |
Pharyngitis | indication | 405737000 | DOID:2275 |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Acute exacerbation of chronic bronchitis | indication | 425748003 | |
Pneumonia due to Staphylococcus aureus | indication | 441658007 | |
Helicobacter pylori-associated gastritis | indication | 708164002 | |
Skin and Skin Structure Streptococcus Infection | indication | ||
E. Coli Genitourinary Tract Infection | indication | ||
Moraxella Catarrhalis Acute Otitis Media | indication | ||
Duodenal Ulcer due to H. Pylori | indication | ||
Haemophilus Influenzae Chronic Bronchitis | indication | ||
Moraxella Catarrhalis Pneumonia | indication | ||
Tonsillitis due to Haemophilus Influenzae | indication | ||
Genitourinary Tract Infections | indication | ||
Haemophilus Influenzae Pharyngitis | indication | ||
Genitourinary Tract Infection due to Proteus | indication | ||
Haemophilus Influenzae Acute Otitis Media | indication | ||
Pneumococcal Acute Otitis Media | indication | ||
Haemophilus Parainfluenzae Pneumonia | indication | ||
Streptococcus Pneumoniae Chronic Bronchitis | indication | ||
Enterococcus Genitourinary Tract Infection | indication | ||
Typhoid fever | off-label use | 4834000 | DOID:13258 |
Pyrexia of unknown origin | off-label use | 7520000 | |
Lyme disease | off-label use | 23502006 | DOID:11729 |
Chronic purulent otitis media | off-label use | 38394007 | DOID:14247 |
Cholangitis | off-label use | 82403002 | DOID:9446 |
Human bite - wound | off-label use | 262555007 | |
Chancroid | off-label use | 266143009 | DOID:13778 |
Diverticulitis of gastrointestinal tract | off-label use | 271366000 | |
Dog bite - wound | off-label use | 283734005 | |
Cat bite - wound | off-label use | 283782004 | |
Prevention of Bacterial Endocarditis | off-label use | ||
Diabetic Foot Infection | off-label use | ||
Prevention of Neonatal Group B Streptococcal Infection | off-label use | ||
Ventricular tachycardia | contraindication | 25569003 | |
Obstruction of bile duct | contraindication | 30144000 | |
Torsades de pointes | contraindication | 31722008 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Cholestatic hepatitis | contraindication | 95556007 | |
Prolonged QT interval | contraindication | 111975006 | |
Fracture of bone | contraindication | 125605004 | |
Liver function tests abnormal | contraindication | 166603001 | |
Hypomagnesemia | contraindication | 190855004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Infectious mononucleosis | contraindication | 271558008 | DOID:8568 |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Porphyria | contraindication | 418470004 |
Species | Use | Relation |
---|---|---|
Cats | Upper respiratory tract infections caused by Staphylococcus aureus | Indication |
Cats | Upper respiratory tract infections caused by Streptococcus spp | Indication |
Cats | Upper respiratory tract infections caused by Escherichia coli | Indication |
Cats | Gastrointestinal tract infections caused by Escherichia coli | Indication |
Cats | Genitourinary tract infections caused by Staphylococcus aureus | Indication |
Cats | Genitourinary tract infections caused by Streptococcus spp | Indication |
Cats | Genitourinary tract infections caused by Escherichia coli | Indication |
Cats | Genitourinary tract infections caused by Proteus species | Indication |
Cats | Skin and soft tissue infections caused by Staphylococcus spp | Indication |
Cats | Skin and soft tissue infections caused by Streptococcus spp | Indication |
Cats | Skin and soft tissue infections caused by Escherichia coli | Indication |
Cats | Skin and soft tissue infectionscaused by Pasteurella multocida | Indication |
Cattle | Bacterial enteritis caused by susceptible Escherichia coli | Indication |
Cattle | Respiratory tract infections caused by Pasteurella multocida | Indication |
Cattle | Respiratory tract infections caused by P hemolytica | Indication |
Cattle | Respiratory tract infections caused by Hemophilus species | Indication |
Cattle | Respiratory tract infections caused by Staphylococci species | Indication |
Cattle | Respiratory tract infections caused by Streptococci species and | Indication |
Cattle | Necrotic pododermatitis (foot rot) caused by Fusobacterium necrophorum | Indication |
Cattle | Bovine mastitis caused by Streptococcus agalactiae | Indication |
Cattle | Bovine mastitis caused by Staphylococcus aureus | Indication |
Dogs | Respiratory tract infection caused by Staphylococcus aureus | Indication |
Dogs | Respiratory tract infections caused by Streptococcus spp | Indication |
Dogs | Respiratory tract infections caused by Escherichia coli | Indication |
Dogs | Respiratory tract infections caused by Proteus mirabilis | Indication |
Dogs | Urinary tract infections caused by Staphylococcus aureus | Indication |
Dogs | Urinary tract infections caused by Streptococcus spp | Indication |
Dogs | Urinary tract infections caused by Escherichia coli | Indication |
Dogs | Urinary tract infections caused by Proteus mirabilis | Indication |
Dogs | Soft tissue infections caused by Staphylococcus aureus | Indication |
Dogs | Soft tissue infections caused by Streptococcus spp | Indication |
Dogs | Soft tissue infections caused by Escherichia coli | Indication |
Dogs | Soft tissue infections caused by Proteus mirabilis | Indication |
Dogs | Bacterial dermatitis caused by Staphylococcus aureus | Indication |
Dogs | Bacterial dermatitis caused by Streptococcus spp | Indication |
Dogs | Bacterial dermatitis caused by Proteus mirabilis | Indication |
Swine | PorcinEscherichia colibacillosis caused by Escherichia coli | Indication |
Product | Applicant | Ingredients |
---|---|---|
Amoxi-Tabs | Zoetis Inc. | 1 |
Amoxi-Doser | Zoetis Inc. | 1 |
Amoxi-Tabs | Zoetis Inc. | 1 |
Amoxi-Drop Oral Suspension | Zoetis Inc. | 1 |
Amoxi-Bol | Zoetis Inc. | 1 |
Amoxi-Sol | Zoetis Inc. | 1 |
Amoxi-Inject (Cattle) | Zoetis Inc. | 1 |
Amoxi-Inject (Dogs and Cats) | Zoetis Inc. | 1 |
CLAVAMOX CHEWABLE Tablets, CLAVAMOX tablets | Zoetis Inc. | 2 |
CLAVAMOX CHEWABLE Tablets, CLAVAMOX tablets | Zoetis Inc. | 2 |
Amoxi-Mast | Intervet Inc. | 1 |
Clavamox Drops | Zoetis Inc. | 2 |
Biomox, Robamox-V Tablets | Virbac AH Inc. | 1 |
Biomox, Robamox-V | Virbac AH Inc. | 1 |
Robamox-V | Zoetis Inc. | 1 |
Robamox-V Tablets | Zoetis Inc. | 1 |
Clavacillin | Dechra Veterinary Products LLC | 2 |
Amoxicillin and Clavulanate Potassium for Oral Suspension | Dechra Veterinary Products LLC | 2 |
Amoxicillin and Clavulanate Potassium Tablets | Cronus Pharma Specialities India Private Limited | 2 |
Amoxicillin and Clavulanate Potassium for Oral Suspension | Cronus Pharma Specialities India Private Limited | 2 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.79 | acidic |
pKa2 | 9.72 | acidic |
pKa3 | 7.63 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
775MG | MOXATAG | PRAGMA | N050813 | Jan. 23, 2008 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 8778924 | Dec. 8, 2026 | METHOD OF TREATING TONSILLITIS AND/OR PHARYNGITIS SECONDARY TO STREPTOCOCCUS PYOGENES IN A ONCE-A-DAY AMOXICILLIN PRODUCT |
775MG | MOXATAG | PRAGMA | N050813 | Jan. 23, 2008 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 8299052 | May 7, 2027 | USE OF ONCE-A-DAY AMOXICILLIN PRODUCT TO TREAT TONSILLITIS AND/OR PHARYNGITIS SECONDARY TO STREPTOCOCCUS PYOGENES |
250MG;EQ 10MG BASE;12.5MG | TALICIA | REDHILL | N213004 | Nov. 1, 2019 | RX | CAPSULE, DELAYED RELEASE | ORAL | 11135172 | Feb. 12, 2034 | TREATMENT OF H. PYLORI INFECTION IN ADULTS |
250MG;EQ 10MG BASE;12.5MG | TALICIA | REDHILL | N213004 | Nov. 1, 2019 | RX | CAPSULE, DELAYED RELEASE | ORAL | 9050263 | Feb. 12, 2034 | TREATMENT OF H. PYLORI INFECTION IN ADULTS |
250MG;EQ 10MG BASE;12.5MG | TALICIA | REDHILL | N213004 | Nov. 1, 2019 | RX | CAPSULE, DELAYED RELEASE | ORAL | 9498445 | Feb. 12, 2034 | TREATMENT OF H. PYLORI INFECTION IN ADULTS |
250MG;EQ 10MG BASE;12.5MG | TALICIA | REDHILL | N213004 | Nov. 1, 2019 | RX | CAPSULE, DELAYED RELEASE | ORAL | 9603806 | Feb. 12, 2034 | TREATMENT OF H. PYLORI INFECTION IN ADULTS |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
500MG;500MG;EQ 20MG BASE | VOQUEZNA TRIPLE PAK | PHATHOM | N215152 | May 3, 2022 | RX | CAPSULE, TABLET, TABLET | ORAL | May 3, 2027 | NEW CHEMICAL ENTITY |
500MG;EQ 20MG BASE | VOQUEZNA DUAL PAK | PHATHOM | N215153 | May 3, 2022 | RX | CAPSULE, TABLET | ORAL | May 3, 2027 | NEW CHEMICAL ENTITY |
500MG;500MG;EQ 20MG BASE | VOQUEZNA TRIPLE PAK | PHATHOM | N215152 | May 3, 2022 | RX | CAPSULE, TABLET, TABLET | ORAL | May 3, 2032 | GENERATING ANTIBIOTIC INCENTIVES NOW |
500MG;EQ 20MG BASE | VOQUEZNA DUAL PAK | PHATHOM | N215153 | May 3, 2022 | RX | CAPSULE, TABLET | ORAL | May 3, 2032 | GENERATING ANTIBIOTIC INCENTIVES NOW |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2A | GPCR | IC50 | 6.22 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2B | GPCR | IC50 | 5.96 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2C | GPCR | IC50 | 5.80 | WOMBAT-PK | |||||
Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Penicillin-binding protein 1A | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
4017605 | VUID |
N0000145985 | NUI |
D00229 | KEGG_DRUG |
34642-77-8 | SECONDARY_CAS_RN |
1297882 | RXNORM |
C0002645 | UMLSCUI |
CHEBI:2676 | CHEBI |
CHEMBL1082 | ChEMBL_ID |
DB01060 | DRUGBANK_ID |
CHEMBL2105950 | ChEMBL_ID |
D000658 | MESH_DESCRIPTOR_UI |
33613 | PUBCHEM_CID |
10895 | IUPHAR_LIGAND_ID |
804826J2HU | UNII |
11786 | MMSL |
3600 | MMSL |
4187 | MMSL |
d00088 | MMSL |
002707 | NDDF |
003675 | NDDF |
003718 | NDDF |
4017604 | VANDF |
4017605 | VANDF |
AXL | PDB_CHEM_ID |
3230 | INN_ID |
27658006 | SNOMEDCT_US |
372687004 | SNOMEDCT_US |
427483001 | SNOMEDCT_US |
785686003 | SNOMEDCT_US |
96068000 | SNOMEDCT_US |
61336-70-7 | SECONDARY_CAS_RN |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2263 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2263 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2264 | TABLET, FILM COATED | 875 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2264 | TABLET, FILM COATED | 875 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2267 | TABLET, CHEWABLE | 125 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2267 | TABLET, CHEWABLE | 125 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2268 | TABLET, CHEWABLE | 250 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-2268 | TABLET, CHEWABLE | 250 mg | ORAL | ANDA | 26 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2270 | TABLET, CHEWABLE | 200 mg | ORAL | ANDA | 26 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2270 | TABLET, CHEWABLE | 200 mg | ORAL | ANDA | 26 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2272 | TABLET, CHEWABLE | 400 mg | ORAL | ANDA | 26 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2272 | TABLET, CHEWABLE | 400 mg | ORAL | ANDA | 26 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2274 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 26 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2274 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 26 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2275 | TABLET, FILM COATED | 875 mg | ORAL | ANDA | 26 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2275 | TABLET, FILM COATED | 875 mg | ORAL | ANDA | 26 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2277 | POWDER, FOR SUSPENSION | 200 mg | ORAL | ANDA | 26 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2277 | POWDER, FOR SUSPENSION | 200 mg | ORAL | ANDA | 26 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2279 | POWDER, FOR SUSPENSION | 400 mg | ORAL | ANDA | 26 sections |
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-2279 | POWDER, FOR SUSPENSION | 400 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3107 | CAPSULE | 250 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3107 | CAPSULE | 250 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3109 | CAPSULE | 500 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-3109 | CAPSULE | 500 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4150 | POWDER, FOR SUSPENSION | 125 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4155 | POWDER, FOR SUSPENSION | 250 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4155 | POWDER, FOR SUSPENSION | 250 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4160 | POWDER, FOR SUSPENSION | 200 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4160 | POWDER, FOR SUSPENSION | 200 mg | ORAL | ANDA | 26 sections |
Amoxicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-4161 | POWDER, FOR SUSPENSION | 400 mg | ORAL | ANDA | 26 sections |