Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, 6-aminopenicillanic acid derivatives | 192 | 26787-78-0 |
Dose | Unit | Route |
---|---|---|
1.50 | g | O |
3 | g | P |
1.50 | g | O |
3 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 3.50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 86 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 68.42 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 93 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.25 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.85 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.10 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 9, 1974 | FDA | APOTHECON |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 1331.41 | 9.50 | 2275 | 115227 | 241550 | 46327010 |
Drug reaction with eosinophilia and systemic symptoms | 625.82 | 9.50 | 550 | 116952 | 28998 | 46539562 |
Rash maculo-papular | 608.76 | 9.50 | 528 | 116974 | 27346 | 46541214 |
Pruritus | 491.55 | 9.50 | 1531 | 115971 | 240821 | 46327739 |
Urticaria | 461.08 | 9.50 | 956 | 116546 | 116936 | 46451624 |
Angioedema | 353.82 | 9.50 | 465 | 117037 | 38877 | 46529683 |
Anaphylactic reaction | 346.91 | 9.50 | 539 | 116963 | 52573 | 46515987 |
Anaphylactic shock | 341.13 | 9.50 | 332 | 117170 | 19942 | 46548618 |
Erythema | 340.10 | 9.50 | 956 | 116546 | 141864 | 46426696 |
Acute generalised exanthematous pustulosis | 335.18 | 9.50 | 238 | 117264 | 9167 | 46559393 |
Rash | 302.70 | 9.50 | 1725 | 115777 | 354787 | 46213773 |
Lip oedema | 264.12 | 9.50 | 141 | 117361 | 3223 | 46565337 |
Type IV hypersensitivity reaction | 259.06 | 9.50 | 127 | 117375 | 2413 | 46566147 |
Cholestasis | 234.25 | 9.50 | 313 | 117189 | 26580 | 46541980 |
Lip swelling | 231.12 | 9.50 | 302 | 117200 | 25093 | 46543467 |
Completed suicide | 226.14 | 9.50 | 46 | 117456 | 145874 | 46422686 |
Toxic skin eruption | 219.97 | 9.50 | 209 | 117293 | 12178 | 46556382 |
Hepatocellular injury | 218.90 | 9.50 | 318 | 117184 | 29204 | 46539356 |
Face oedema | 213.18 | 9.50 | 252 | 117250 | 18901 | 46549659 |
Drug-induced liver injury | 199.45 | 9.50 | 281 | 117221 | 25087 | 46543473 |
Maternal exposure during pregnancy | 196.29 | 9.50 | 636 | 116866 | 101913 | 46466647 |
Drug ineffective | 191.24 | 9.50 | 969 | 116533 | 676869 | 45891691 |
Death | 182.89 | 9.50 | 355 | 117147 | 335193 | 46233367 |
Abortion spontaneous | 182.21 | 9.50 | 364 | 117138 | 43282 | 46525278 |
Rheumatoid arthritis | 175.32 | 9.50 | 208 | 117294 | 240007 | 46328553 |
Acute kidney injury | 171.37 | 9.50 | 1097 | 116405 | 234758 | 46333802 |
Jaundice | 166.70 | 9.50 | 277 | 117225 | 28568 | 46539992 |
Type I hypersensitivity | 158.38 | 9.50 | 89 | 117413 | 2257 | 46566303 |
Clostridium difficile infection | 153.08 | 9.50 | 247 | 117255 | 24856 | 46543704 |
Hepatitis cholestatic | 152.82 | 9.50 | 130 | 117372 | 6547 | 46562013 |
Stevens-Johnson syndrome | 150.01 | 9.50 | 235 | 117267 | 23062 | 46545498 |
Fall | 141.60 | 9.50 | 395 | 117107 | 328702 | 46239858 |
Eosinophilia | 136.65 | 9.50 | 203 | 117299 | 19014 | 46549546 |
Documented hypersensitivity to administered product | 134.83 | 9.50 | 52 | 117450 | 533 | 46568027 |
Tongue oedema | 121.52 | 9.50 | 92 | 117410 | 3914 | 46564646 |
Tubulointerstitial nephritis | 120.99 | 9.50 | 167 | 117335 | 14621 | 46553939 |
Enterocolitis haemorrhagic | 119.35 | 9.50 | 64 | 117438 | 1476 | 46567084 |
Crystalluria | 117.41 | 9.50 | 43 | 117459 | 377 | 46568183 |
Rash pruritic | 115.98 | 9.50 | 307 | 117195 | 43908 | 46524652 |
Swollen tongue | 113.93 | 9.50 | 237 | 117265 | 28995 | 46539565 |
Toxic epidermal necrolysis | 113.06 | 9.50 | 202 | 117300 | 22076 | 46546484 |
Clostridium difficile colitis | 112.36 | 9.50 | 182 | 117320 | 18371 | 46550189 |
Erythema multiforme | 111.83 | 9.50 | 130 | 117372 | 9574 | 46558986 |
Rash macular | 108.66 | 9.50 | 183 | 117319 | 19077 | 46549483 |
Infusion related reaction | 103.87 | 9.50 | 63 | 117439 | 101145 | 46467415 |
Arthralgia | 103.55 | 9.50 | 519 | 116983 | 364084 | 46204476 |
Pyrexia | 94.66 | 9.50 | 1314 | 116188 | 347488 | 46221072 |
Rash erythematous | 92.63 | 9.50 | 241 | 117261 | 34109 | 46534451 |
Toxicity to various agents | 92.56 | 9.50 | 252 | 117250 | 211514 | 46357046 |
Fatigue | 91.37 | 9.50 | 1037 | 116465 | 607660 | 45960900 |
Therapeutic product effect decreased | 91.12 | 9.50 | 47 | 117455 | 82554 | 46486006 |
Pemphigus | 87.47 | 9.50 | 7 | 117495 | 45267 | 46523293 |
Swelling face | 86.44 | 9.50 | 312 | 117190 | 52747 | 46515813 |
White blood cell count abnormal | 82.49 | 9.50 | 82 | 117420 | 5050 | 46563510 |
Wound closure | 80.04 | 9.50 | 26 | 117476 | 152 | 46568408 |
Pseudomembranous colitis | 78.89 | 9.50 | 65 | 117437 | 3130 | 46565430 |
Dermatitis allergic | 75.45 | 9.50 | 123 | 117379 | 12480 | 46556080 |
Off label use | 73.81 | 9.50 | 607 | 116895 | 379234 | 46189326 |
Arthropathy | 73.48 | 9.50 | 63 | 117439 | 84637 | 46483923 |
Meningitis aseptic | 73.03 | 9.50 | 69 | 117433 | 3990 | 46564570 |
Palatal oedema | 72.14 | 9.50 | 32 | 117470 | 479 | 46568081 |
Cholecystitis chronic | 71.91 | 9.50 | 109 | 117393 | 10390 | 46558170 |
Hand deformity | 70.73 | 9.50 | 4 | 117498 | 34570 | 46533990 |
Eyelid oedema | 70.20 | 9.50 | 107 | 117395 | 10250 | 46558310 |
Cholestatic liver injury | 70.12 | 9.50 | 51 | 117451 | 2039 | 46566521 |
Dermatitis exfoliative generalised | 69.64 | 9.50 | 59 | 117443 | 2954 | 46565606 |
Therapeutic product effect incomplete | 69.18 | 9.50 | 57 | 117445 | 78096 | 46490464 |
Osteotomy | 68.61 | 9.50 | 26 | 117476 | 253 | 46568307 |
Mixed liver injury | 65.47 | 9.50 | 58 | 117444 | 3085 | 46565475 |
Diarrhoea | 65.45 | 9.50 | 1856 | 115646 | 557746 | 46010814 |
Injection site pain | 64.82 | 9.50 | 106 | 117396 | 107046 | 46461514 |
Injection site erythema | 63.78 | 9.50 | 56 | 117446 | 74371 | 46494189 |
Rash morbilliform | 63.62 | 9.50 | 56 | 117446 | 2953 | 46565607 |
Liver injury | 62.65 | 9.50 | 130 | 117372 | 15871 | 46552689 |
Hypersensitivity | 60.43 | 9.50 | 611 | 116891 | 149710 | 46418850 |
Drug eruption | 59.93 | 9.50 | 152 | 117350 | 21177 | 46547383 |
Synovitis | 59.92 | 9.50 | 40 | 117462 | 61035 | 46507525 |
Myocardial infarction | 59.43 | 9.50 | 96 | 117406 | 97432 | 46471128 |
Alopecia | 58.41 | 9.50 | 211 | 117291 | 162203 | 46406357 |
Weight increased | 58.27 | 9.50 | 215 | 117287 | 164258 | 46404302 |
Idiosyncratic drug reaction | 57.53 | 9.50 | 32 | 117470 | 795 | 46567765 |
Paraesthesia oral | 57.50 | 9.50 | 105 | 117397 | 11668 | 46556892 |
Breast cancer | 54.67 | 9.50 | 23 | 117479 | 45495 | 46523065 |
Joint swelling | 54.41 | 9.50 | 224 | 117278 | 165849 | 46402711 |
Loss of personal independence in daily activities | 54.05 | 9.50 | 39 | 117463 | 57144 | 46511416 |
Hepatitis | 53.79 | 9.50 | 191 | 117311 | 32024 | 46536536 |
Kounis syndrome | 53.72 | 9.50 | 35 | 117467 | 1167 | 46567393 |
Sinusitis | 51.44 | 9.50 | 526 | 116976 | 129242 | 46439318 |
Arthritis | 50.08 | 9.50 | 73 | 117429 | 77243 | 46491317 |
Linear IgA disease | 49.77 | 9.50 | 35 | 117467 | 1326 | 46567234 |
Bronchospasm | 49.51 | 9.50 | 117 | 117385 | 15590 | 46552970 |
Pain in extremity | 49.41 | 9.50 | 415 | 117087 | 258265 | 46310295 |
Treatment failure | 48.38 | 9.50 | 101 | 117401 | 92986 | 46475574 |
Vascular purpura | 47.80 | 9.50 | 34 | 117468 | 1312 | 46567248 |
Acute hepatic failure | 45.69 | 9.50 | 109 | 117393 | 14612 | 46553948 |
Device expulsion | 44.06 | 9.50 | 8 | 117494 | 27534 | 46541026 |
Klebsiella infection | 43.98 | 9.50 | 68 | 117434 | 6594 | 46561966 |
Glossodynia | 43.61 | 9.50 | 29 | 117473 | 44344 | 46524216 |
Dermatitis bullous | 43.61 | 9.50 | 73 | 117429 | 7570 | 46560990 |
Chromaturia | 43.20 | 9.50 | 108 | 117394 | 14911 | 46553649 |
Injection site swelling | 42.92 | 9.50 | 24 | 117478 | 40303 | 46528257 |
Periorbital oedema | 42.90 | 9.50 | 58 | 117444 | 4977 | 46563583 |
Agranulocytosis | 42.73 | 9.50 | 138 | 117364 | 22047 | 46546513 |
Jaundice cholestatic | 39.94 | 9.50 | 56 | 117446 | 4973 | 46563587 |
Odynophagia | 39.85 | 9.50 | 65 | 117437 | 6597 | 46561963 |
Systemic lupus erythematosus | 38.92 | 9.50 | 65 | 117437 | 65115 | 46503445 |
Product use issue | 38.09 | 9.50 | 117 | 117385 | 94527 | 46474033 |
Basilar artery occlusion | 38.00 | 9.50 | 14 | 117488 | 125 | 46568435 |
Symmetrical drug-related intertriginous and flexural exanthema | 37.70 | 9.50 | 17 | 117485 | 265 | 46568295 |
Laryngeal oedema | 37.53 | 9.50 | 56 | 117446 | 5263 | 46563297 |
Tooth demineralisation | 37.29 | 9.50 | 9 | 117493 | 12 | 46568548 |
Cardiac failure congestive | 37.22 | 9.50 | 113 | 117389 | 91637 | 46476923 |
Blood pressure increased | 37.15 | 9.50 | 178 | 117324 | 126488 | 46442072 |
Hyperaemia | 36.10 | 9.50 | 34 | 117468 | 1958 | 46566602 |
Tryptase increased | 35.51 | 9.50 | 15 | 117487 | 198 | 46568362 |
Dermatitis exfoliative | 34.50 | 9.50 | 56 | 117446 | 5660 | 46562900 |
Neutrophilia | 34.50 | 9.50 | 40 | 117462 | 2937 | 46565623 |
Lymphadenopathy | 34.29 | 9.50 | 171 | 117331 | 33317 | 46535243 |
Injection site pruritus | 33.92 | 9.50 | 30 | 117472 | 39713 | 46528847 |
Wound | 33.40 | 9.50 | 35 | 117467 | 42767 | 46525793 |
Platelet count decreased | 33.31 | 9.50 | 134 | 117368 | 99890 | 46468670 |
Throat tightness | 33.28 | 9.50 | 121 | 117381 | 20518 | 46548042 |
Ear infection | 33.04 | 9.50 | 130 | 117372 | 22883 | 46545677 |
Injury | 32.58 | 9.50 | 206 | 117296 | 43821 | 46524739 |
Hepatitis acute | 32.46 | 9.50 | 67 | 117435 | 8147 | 46560413 |
Choluria | 32.34 | 9.50 | 13 | 117489 | 150 | 46568410 |
Trimethylaminuria | 31.88 | 9.50 | 13 | 117489 | 156 | 46568404 |
Pharyngeal swelling | 31.77 | 9.50 | 41 | 117461 | 3362 | 46565198 |
Knee arthroplasty | 31.73 | 9.50 | 10 | 117492 | 23655 | 46544905 |
Purpura | 31.19 | 9.50 | 74 | 117428 | 9884 | 46558676 |
Blood glucose increased | 30.43 | 9.50 | 87 | 117415 | 71926 | 46496634 |
Peritonsillar abscess | 30.24 | 9.50 | 18 | 117484 | 510 | 46568050 |
Premature baby | 29.90 | 9.50 | 107 | 117395 | 18005 | 46550555 |
Drug intolerance | 29.83 | 9.50 | 232 | 117270 | 146817 | 46421743 |
Premature delivery | 29.56 | 9.50 | 122 | 117380 | 21947 | 46546613 |
Contraindicated product administered | 29.28 | 9.50 | 103 | 117399 | 79844 | 46488716 |
Staphylococcal scalded skin syndrome | 29.28 | 9.50 | 12 | 117490 | 146 | 46568414 |
Drug interaction | 29.22 | 9.50 | 693 | 116809 | 202401 | 46366159 |
Candida infection | 29.05 | 9.50 | 122 | 117380 | 22118 | 46546442 |
Tooth infection | 28.90 | 9.50 | 82 | 117420 | 12204 | 46556356 |
Diabetes mellitus | 28.90 | 9.50 | 51 | 117451 | 50014 | 46518546 |
Lower respiratory tract infection | 28.75 | 9.50 | 237 | 117265 | 54852 | 46513708 |
Pain | 28.42 | 9.50 | 950 | 116552 | 475998 | 46092562 |
Hyperleukocytosis | 28.32 | 9.50 | 16 | 117486 | 410 | 46568150 |
Wrong technique in product usage process | 28.31 | 9.50 | 59 | 117443 | 54363 | 46514197 |
Isosthenuria | 27.91 | 9.50 | 11 | 117491 | 120 | 46568440 |
Hallucinations, mixed | 27.84 | 9.50 | 41 | 117461 | 3808 | 46564752 |
Vomiting | 27.79 | 9.50 | 1399 | 116103 | 451395 | 46117165 |
Enanthema | 27.14 | 9.50 | 16 | 117486 | 445 | 46568115 |
Hypertension | 27.14 | 9.50 | 340 | 117162 | 196016 | 46372544 |
Moraxella test positive | 26.93 | 9.50 | 7 | 117495 | 15 | 46568545 |
Skin exfoliation | 26.83 | 9.50 | 158 | 117344 | 32780 | 46535780 |
International normalised ratio increased | 26.82 | 9.50 | 206 | 117296 | 46677 | 46521883 |
Skin test positive | 26.81 | 9.50 | 19 | 117483 | 729 | 46567831 |
Vitiligo | 26.71 | 9.50 | 22 | 117480 | 1059 | 46567501 |
Foetal exposure during pregnancy | 26.68 | 9.50 | 150 | 117352 | 30597 | 46537963 |
Injection site reaction | 26.50 | 9.50 | 50 | 117452 | 47799 | 46520761 |
Mobility decreased | 26.50 | 9.50 | 72 | 117430 | 60522 | 46508038 |
Abdominal discomfort | 25.98 | 9.50 | 249 | 117253 | 150916 | 46417644 |
Localised oedema | 25.76 | 9.50 | 46 | 117456 | 5023 | 46563537 |
Skin lesion | 25.67 | 9.50 | 134 | 117368 | 26579 | 46541981 |
Emotional distress | 25.46 | 9.50 | 148 | 117354 | 30559 | 46538001 |
Multiple sclerosis relapse | 25.15 | 9.50 | 42 | 117460 | 42083 | 46526477 |
Lemierre syndrome | 25.06 | 9.50 | 10 | 117492 | 113 | 46568447 |
Laryngeal discomfort | 24.96 | 9.50 | 13 | 117489 | 282 | 46568278 |
Wheezing | 24.88 | 9.50 | 224 | 117278 | 53162 | 46515398 |
Swelling of eyelid | 24.85 | 9.50 | 22 | 117480 | 1169 | 46567391 |
Chronic kidney disease | 24.74 | 9.50 | 182 | 117320 | 40689 | 46527871 |
Malaise | 24.51 | 9.50 | 1043 | 116459 | 330189 | 46238371 |
Pyelitis | 24.48 | 9.50 | 11 | 117491 | 170 | 46568390 |
Salpingo-oophorectomy unilateral | 24.39 | 9.50 | 14 | 117488 | 370 | 46568190 |
Fluid retention | 24.37 | 9.50 | 58 | 117444 | 50988 | 46517572 |
Injection site warmth | 24.33 | 9.50 | 3 | 117499 | 13769 | 46554791 |
Pharyngeal oedema | 24.32 | 9.50 | 86 | 117416 | 14385 | 46554175 |
Electrocardiogram PR shortened | 24.31 | 9.50 | 11 | 117491 | 173 | 46568387 |
Headache | 24.17 | 9.50 | 972 | 116530 | 477380 | 46091180 |
Faeces pale | 24.14 | 9.50 | 24 | 117478 | 1478 | 46567082 |
Fibromyalgia | 24.03 | 9.50 | 34 | 117468 | 36429 | 46532131 |
Fracture | 23.86 | 9.50 | 6 | 117496 | 16465 | 46552095 |
Drug abuse | 23.69 | 9.50 | 81 | 117421 | 63327 | 46505233 |
Cardio-respiratory arrest | 23.38 | 9.50 | 75 | 117427 | 59794 | 46508766 |
Erythromelalgia | 23.34 | 9.50 | 10 | 117492 | 137 | 46568423 |
Peripheral circulatory failure | 23.23 | 9.50 | 13 | 117489 | 327 | 46568233 |
Tongue discolouration | 23.19 | 9.50 | 33 | 117469 | 2971 | 46565589 |
Exposure during pregnancy | 23.17 | 9.50 | 392 | 117110 | 107820 | 46460740 |
Dental operation | 23.08 | 9.50 | 21 | 117481 | 1157 | 46567403 |
Disease progression | 23.02 | 9.50 | 135 | 117367 | 91165 | 46477395 |
Pericarditis | 23.02 | 9.50 | 16 | 117486 | 23911 | 46544649 |
Somatic delusion | 22.97 | 9.50 | 16 | 117486 | 597 | 46567963 |
Intentional product misuse | 22.94 | 9.50 | 53 | 117449 | 47075 | 46521485 |
Infectious mononucleosis | 22.92 | 9.50 | 24 | 117478 | 1572 | 46566988 |
Leukocytosis | 22.92 | 9.50 | 118 | 117384 | 23280 | 46545280 |
Bladder hypertrophy | 22.34 | 9.50 | 11 | 117491 | 211 | 46568349 |
Rash pustular | 22.26 | 9.50 | 52 | 117450 | 6877 | 46561683 |
Sinusitis fungal | 21.97 | 9.50 | 18 | 117484 | 860 | 46567700 |
Mental status changes | 21.80 | 9.50 | 39 | 117463 | 38049 | 46530511 |
Oral discomfort | 21.79 | 9.50 | 56 | 117446 | 7862 | 46560698 |
Protein C increased | 21.67 | 9.50 | 10 | 117492 | 165 | 46568395 |
Haemolytic anaemia | 21.53 | 9.50 | 64 | 117438 | 9778 | 46558782 |
Therapeutic response decreased | 21.42 | 9.50 | 48 | 117454 | 43097 | 46525463 |
Transaminases increased | 21.23 | 9.50 | 131 | 117371 | 27630 | 46540930 |
Oliguria | 21.13 | 9.50 | 59 | 117443 | 8700 | 46559860 |
Respiratory symptom | 21.01 | 9.50 | 26 | 117476 | 2044 | 46566516 |
Malignant neoplasm progression | 20.97 | 9.50 | 88 | 117414 | 64838 | 46503722 |
Tonsillar exudate | 20.95 | 9.50 | 6 | 117496 | 21 | 46568539 |
Renal papillary necrosis | 20.90 | 9.50 | 11 | 117491 | 244 | 46568316 |
Gastrointestinal haemorrhage | 20.81 | 9.50 | 112 | 117390 | 77261 | 46491299 |
Haematuria | 20.70 | 9.50 | 127 | 117375 | 26731 | 46541829 |
Product complaint | 20.51 | 9.50 | 3 | 117499 | 12098 | 46556462 |
Distributive shock | 20.47 | 9.50 | 14 | 117488 | 507 | 46568053 |
Hip arthroplasty | 20.42 | 9.50 | 10 | 117492 | 18102 | 46550458 |
Pharyngitis streptococcal | 20.39 | 9.50 | 57 | 117445 | 8411 | 46560149 |
Rash papular | 20.28 | 9.50 | 75 | 117427 | 12823 | 46555737 |
Empyema | 20.23 | 9.50 | 24 | 117478 | 1806 | 46566754 |
Conjunctival hyperaemia | 20.21 | 9.50 | 25 | 117477 | 1964 | 46566596 |
Eye swelling | 20.12 | 9.50 | 102 | 117400 | 20001 | 46548559 |
Injection site bruising | 19.94 | 9.50 | 37 | 117465 | 35599 | 46532961 |
Influenza B virus test positive | 19.73 | 9.50 | 12 | 117490 | 354 | 46568206 |
Conjunctivitis | 19.67 | 9.50 | 84 | 117418 | 15340 | 46553220 |
Blood cholesterol increased | 19.47 | 9.50 | 45 | 117457 | 39968 | 46528592 |
Viral parotitis | 19.47 | 9.50 | 5 | 117497 | 10 | 46568550 |
Inappropriate schedule of product administration | 19.26 | 9.50 | 91 | 117411 | 64922 | 46503638 |
Eosinophilic pneumonia | 19.06 | 9.50 | 24 | 117478 | 1920 | 46566640 |
Tonsillitis | 19.04 | 9.50 | 40 | 117462 | 4924 | 46563636 |
Product dose omission issue | 18.96 | 9.50 | 304 | 117198 | 168216 | 46400344 |
Cell death | 18.95 | 9.50 | 26 | 117476 | 2262 | 46566298 |
Normal tension glaucoma | 18.67 | 9.50 | 7 | 117495 | 66 | 46568494 |
Incorrect route of product administration | 18.54 | 9.50 | 9 | 117493 | 16374 | 46552186 |
Nausea | 18.52 | 9.50 | 1485 | 116017 | 685969 | 45882591 |
Otitis media | 18.45 | 9.50 | 36 | 117466 | 4204 | 46564356 |
Tongue coated | 18.34 | 9.50 | 19 | 117483 | 1229 | 46567331 |
Foetal non-stress test abnormal | 18.34 | 9.50 | 6 | 117496 | 36 | 46568524 |
Pharyngotonsillitis | 18.26 | 9.50 | 9 | 117493 | 173 | 46568387 |
Contraindicated product prescribed | 18.17 | 9.50 | 15 | 117487 | 724 | 46567836 |
Hypertransaminasaemia | 18.17 | 9.50 | 32 | 117470 | 3456 | 46565104 |
Biliary colic | 18.10 | 9.50 | 32 | 117470 | 3466 | 46565094 |
Fixed eruption | 18.09 | 9.50 | 16 | 117486 | 849 | 46567711 |
Pharyngeal erythema | 18.09 | 9.50 | 21 | 117481 | 1544 | 46567016 |
Lymphocytosis | 17.93 | 9.50 | 25 | 117477 | 2209 | 46566351 |
Mania | 17.84 | 9.50 | 64 | 117438 | 10782 | 46557778 |
Underdose | 17.63 | 9.50 | 14 | 117488 | 19544 | 46549016 |
Joint range of motion decreased | 17.59 | 9.50 | 8 | 117494 | 15116 | 46553444 |
Red blood cell sedimentation rate increased | 17.54 | 9.50 | 19 | 117483 | 22870 | 46545690 |
Hepatic enzyme increased | 17.54 | 9.50 | 127 | 117375 | 81660 | 46486900 |
Pharyngeal paraesthesia | 17.53 | 9.50 | 18 | 117484 | 1152 | 46567408 |
Cheilitis | 17.52 | 9.50 | 34 | 117468 | 3954 | 46564606 |
Depression | 17.46 | 9.50 | 312 | 117190 | 169792 | 46398768 |
Neisseria infection | 17.43 | 9.50 | 6 | 117496 | 43 | 46568517 |
Hyperthermia | 17.42 | 9.50 | 52 | 117450 | 7962 | 46560598 |
Psychotic symptom | 17.39 | 9.50 | 16 | 117486 | 894 | 46567666 |
Faeces discoloured | 17.38 | 9.50 | 86 | 117416 | 16701 | 46551859 |
Medication crystals in urine present | 17.19 | 9.50 | 4 | 117498 | 4 | 46568556 |
Dyspnoea | 17.17 | 9.50 | 1513 | 115989 | 514035 | 46054525 |
Femur fracture | 16.90 | 9.50 | 43 | 117459 | 36954 | 46531606 |
Rash vesicular | 16.90 | 9.50 | 31 | 117471 | 3456 | 46565104 |
Mouth swelling | 16.88 | 9.50 | 32 | 117470 | 3657 | 46564903 |
Oral candidiasis | 16.88 | 9.50 | 88 | 117414 | 17444 | 46551116 |
Megacolon | 16.78 | 9.50 | 21 | 117481 | 1670 | 46566890 |
Blood pressure fluctuation | 16.70 | 9.50 | 32 | 117470 | 30416 | 46538144 |
Gait disturbance | 16.69 | 9.50 | 261 | 117241 | 145002 | 46423558 |
Tinnitus | 16.61 | 9.50 | 123 | 117379 | 27550 | 46541010 |
Pyogenic granuloma | 16.53 | 9.50 | 10 | 117492 | 292 | 46568268 |
Balance disorder | 16.48 | 9.50 | 95 | 117407 | 64426 | 46504134 |
Multiple sclerosis | 16.45 | 9.50 | 23 | 117479 | 24768 | 46543792 |
Pneumonia mycoplasmal | 16.38 | 9.50 | 15 | 117487 | 833 | 46567727 |
Periorbital cellulitis | 16.32 | 9.50 | 12 | 117490 | 488 | 46568072 |
Respiratory tract infection | 16.20 | 9.50 | 130 | 117372 | 29842 | 46538718 |
Sputum increased | 16.15 | 9.50 | 21 | 117481 | 1735 | 46566825 |
Medication error | 16.13 | 9.50 | 133 | 117369 | 30778 | 46537782 |
Back pain | 16.07 | 9.50 | 404 | 117098 | 209635 | 46358925 |
Injection site rash | 15.99 | 9.50 | 10 | 117492 | 15803 | 46552757 |
Periorbital swelling | 15.99 | 9.50 | 18 | 117484 | 1280 | 46567280 |
Phaeohyphomycosis | 15.85 | 9.50 | 9 | 117493 | 233 | 46568327 |
Skin reaction | 15.85 | 9.50 | 62 | 117440 | 10884 | 46557676 |
Embolism venous | 15.73 | 9.50 | 25 | 117477 | 2482 | 46566078 |
Fulminant type 1 diabetes mellitus | 15.51 | 9.50 | 9 | 117493 | 243 | 46568317 |
Suicidal ideation | 15.50 | 9.50 | 81 | 117421 | 56301 | 46512259 |
Musculoskeletal pain | 15.47 | 9.50 | 108 | 117394 | 70020 | 46498540 |
Psoriasis | 15.47 | 9.50 | 125 | 117377 | 78479 | 46490081 |
Ankle fracture | 15.42 | 9.50 | 10 | 117492 | 15501 | 46553059 |
Herpes zoster | 15.23 | 9.50 | 104 | 117398 | 67768 | 46500792 |
Osteoporosis | 15.08 | 9.50 | 52 | 117450 | 40556 | 46528004 |
Bipolar I disorder | 15.02 | 9.50 | 19 | 117483 | 1527 | 46567033 |
Yellow skin | 14.95 | 9.50 | 22 | 117480 | 2042 | 46566518 |
Induced abortion failed | 14.93 | 9.50 | 9 | 117493 | 261 | 46568299 |
Eczema | 14.81 | 9.50 | 95 | 117407 | 20305 | 46548255 |
Abnormal faeces | 14.81 | 9.50 | 32 | 117470 | 4017 | 46564543 |
Joint injury | 14.66 | 9.50 | 16 | 117486 | 19193 | 46549367 |
Discomfort | 14.61 | 9.50 | 64 | 117438 | 46606 | 46521954 |
White blood cell count decreased | 14.51 | 9.50 | 197 | 117305 | 112034 | 46456526 |
Upper limb fracture | 14.48 | 9.50 | 11 | 117491 | 15702 | 46552858 |
Peripheral swelling | 14.36 | 9.50 | 296 | 117206 | 157775 | 46410785 |
Memory impairment | 14.31 | 9.50 | 125 | 117377 | 77212 | 46491348 |
Chronic sinusitis | 14.27 | 9.50 | 36 | 117466 | 4997 | 46563563 |
Bradycardia | 14.19 | 9.50 | 103 | 117399 | 66195 | 46502365 |
Blood glucose decreased | 14.13 | 9.50 | 16 | 117486 | 18876 | 46549684 |
Mucosal inflammation | 14.02 | 9.50 | 155 | 117347 | 38821 | 46529739 |
Thermal burn | 13.95 | 9.50 | 35 | 117467 | 4842 | 46563718 |
Feeling abnormal | 13.93 | 9.50 | 226 | 117276 | 124834 | 46443726 |
Pericardial effusion | 13.87 | 9.50 | 27 | 117475 | 25516 | 46543044 |
Norovirus test positive | 13.82 | 9.50 | 7 | 117495 | 143 | 46568417 |
Neoplasm progression | 13.81 | 9.50 | 29 | 117473 | 26654 | 46541906 |
Systemic inflammatory response syndrome | 13.78 | 9.50 | 37 | 117465 | 5334 | 46563226 |
Live birth | 13.75 | 9.50 | 57 | 117445 | 10273 | 46558287 |
Ecthyma | 13.72 | 9.50 | 8 | 117494 | 218 | 46568342 |
Amnesia | 13.71 | 9.50 | 56 | 117446 | 41575 | 46526985 |
Respiratory depression | 13.70 | 9.50 | 6 | 117496 | 11594 | 46556966 |
Pharyngeal abscess | 13.69 | 9.50 | 8 | 117494 | 219 | 46568341 |
Deafness | 13.68 | 9.50 | 78 | 117424 | 15990 | 46552570 |
Anuria | 13.62 | 9.50 | 61 | 117441 | 11370 | 46557190 |
Cerebrovascular accident | 13.55 | 9.50 | 176 | 117326 | 100863 | 46467697 |
Accidental exposure to product | 13.55 | 9.50 | 20 | 117482 | 21061 | 46547499 |
Overdose | 13.55 | 9.50 | 178 | 117324 | 101801 | 46466759 |
Diastasis recti abdominis | 13.54 | 9.50 | 5 | 117497 | 45 | 46568515 |
Blood count abnormal | 13.52 | 9.50 | 15 | 117487 | 17863 | 46550697 |
Metastases to lung | 13.51 | 9.50 | 5 | 117497 | 10691 | 46557869 |
Prothrombin time ratio decreased | 13.49 | 9.50 | 10 | 117492 | 412 | 46568148 |
Pulmonary artery stenosis congenital | 13.46 | 9.50 | 8 | 117494 | 226 | 46568334 |
Parotid gland enlargement | 13.34 | 9.50 | 13 | 117489 | 781 | 46567779 |
Dysbiosis | 13.33 | 9.50 | 11 | 117491 | 531 | 46568029 |
Depressed level of consciousness | 13.27 | 9.50 | 68 | 117434 | 47501 | 46521059 |
Bronchopleural fistula | 13.21 | 9.50 | 8 | 117494 | 234 | 46568326 |
Progressive multifocal leukoencephalopathy | 13.20 | 9.50 | 6 | 117496 | 11340 | 46557220 |
Urea urine increased | 13.18 | 9.50 | 4 | 117498 | 18 | 46568542 |
Eosinophils urine present | 13.18 | 9.50 | 4 | 117498 | 18 | 46568542 |
Drug withdrawal syndrome | 13.16 | 9.50 | 31 | 117471 | 27353 | 46541207 |
Prothrombin time shortened | 13.11 | 9.50 | 19 | 117483 | 1740 | 46566820 |
Femoral artery embolism | 12.99 | 9.50 | 5 | 117497 | 51 | 46568509 |
Dyskinesia | 12.92 | 9.50 | 34 | 117468 | 28891 | 46539669 |
Arthritis allergic | 12.89 | 9.50 | 3 | 117499 | 3 | 46568557 |
Biliary sepsis | 12.86 | 9.50 | 11 | 117491 | 558 | 46568002 |
Labelled drug-drug interaction medication error | 12.86 | 9.50 | 51 | 117451 | 9010 | 46559550 |
Cholestasis of pregnancy | 12.85 | 9.50 | 15 | 117487 | 1109 | 46567451 |
Peritonitis bacterial | 12.83 | 9.50 | 3 | 117499 | 8650 | 46559910 |
Hip fracture | 12.81 | 9.50 | 30 | 117472 | 26526 | 46542034 |
Erythema nodosum | 12.81 | 9.50 | 29 | 117473 | 3757 | 46564803 |
Fear-related avoidance of activities | 12.79 | 9.50 | 6 | 117496 | 103 | 46568457 |
Foetal hypokinesia | 12.76 | 9.50 | 10 | 117492 | 448 | 46568112 |
Pulmonary hypertension | 12.76 | 9.50 | 47 | 117455 | 35946 | 46532614 |
Coronary artery disease | 12.68 | 9.50 | 43 | 117459 | 33709 | 46534851 |
Caffeine allergy | 12.67 | 9.50 | 4 | 117498 | 21 | 46568539 |
Sedation | 12.63 | 9.50 | 24 | 117478 | 22886 | 46545674 |
Oedema | 12.58 | 9.50 | 238 | 117264 | 66833 | 46501727 |
Dysphonia | 12.58 | 9.50 | 150 | 117352 | 38264 | 46530296 |
Adverse event | 12.54 | 9.50 | 44 | 117458 | 34140 | 46534420 |
Tangentiality | 12.52 | 9.50 | 4 | 117498 | 22 | 46568538 |
Duodenal ulcer perforation | 12.51 | 9.50 | 3 | 117499 | 8499 | 46560061 |
Toothache | 12.50 | 9.50 | 78 | 117424 | 16514 | 46552046 |
Polymenorrhagia | 12.49 | 9.50 | 5 | 117497 | 57 | 46568503 |
Syncope | 12.47 | 9.50 | 187 | 117315 | 104616 | 46463944 |
Nasal polyps | 12.46 | 9.50 | 21 | 117481 | 2189 | 46566371 |
Lower respiratory tract infection bacterial | 12.46 | 9.50 | 9 | 117493 | 356 | 46568204 |
Gait inability | 12.46 | 9.50 | 46 | 117456 | 35157 | 46533403 |
Excessive eye blinking | 12.43 | 9.50 | 11 | 117491 | 584 | 46567976 |
Lymphadenitis | 12.42 | 9.50 | 23 | 117479 | 2582 | 46565978 |
Gallbladder disorder | 12.40 | 9.50 | 81 | 117421 | 17417 | 46551143 |
Acute haemorrhagic oedema of infancy | 12.37 | 9.50 | 4 | 117498 | 23 | 46568537 |
Cardiac failure | 12.36 | 9.50 | 135 | 117367 | 79813 | 46488747 |
Circulatory collapse | 12.35 | 9.50 | 95 | 117407 | 21529 | 46547031 |
Restless legs syndrome | 12.31 | 9.50 | 13 | 117489 | 15830 | 46552730 |
Gastric disorder | 12.23 | 9.50 | 31 | 117471 | 26674 | 46541886 |
Abdominal pain upper | 12.20 | 9.50 | 464 | 117038 | 144841 | 46423719 |
Metastases to liver | 12.18 | 9.50 | 19 | 117483 | 19566 | 46548994 |
Creatinine renal clearance increased | 12.18 | 9.50 | 10 | 117492 | 479 | 46568081 |
Sebaceous gland infection | 12.14 | 9.50 | 6 | 117496 | 116 | 46568444 |
Myelodysplastic syndrome | 12.08 | 9.50 | 13 | 117489 | 15698 | 46552862 |
Injury corneal | 12.05 | 9.50 | 5 | 117497 | 63 | 46568497 |
Budd-Chiari syndrome | 12.05 | 9.50 | 5 | 117497 | 63 | 46568497 |
Otitis media acute | 11.98 | 9.50 | 13 | 117489 | 887 | 46567673 |
C-reactive protein abnormal | 11.97 | 9.50 | 22 | 117480 | 21248 | 46547312 |
Clostridium test positive | 11.97 | 9.50 | 19 | 117483 | 1885 | 46566675 |
Pulmonary arterial hypertension | 11.95 | 9.50 | 30 | 117472 | 25898 | 46542662 |
Atrial fibrillation | 11.93 | 9.50 | 186 | 117316 | 103404 | 46465156 |
Abdominal pain | 11.92 | 9.50 | 700 | 116802 | 229331 | 46339229 |
Pseudomyopia | 11.91 | 9.50 | 5 | 117497 | 65 | 46568495 |
Device issue | 11.85 | 9.50 | 20 | 117482 | 19960 | 46548600 |
Visual impairment | 11.81 | 9.50 | 109 | 117393 | 66580 | 46501980 |
Neoplasm malignant | 11.78 | 9.50 | 26 | 117476 | 23473 | 46545087 |
Laryngeal obstruction | 11.70 | 9.50 | 4 | 117498 | 28 | 46568532 |
Prescribed underdose | 11.68 | 9.50 | 8 | 117494 | 12045 | 46556515 |
Oropharyngeal discomfort | 11.67 | 9.50 | 25 | 117477 | 3120 | 46565440 |
Right ventricular failure | 11.63 | 9.50 | 14 | 117488 | 16079 | 46552481 |
Neonatal respiratory distress syndrome | 11.63 | 9.50 | 22 | 117480 | 2511 | 46566049 |
Product colour issue | 11.58 | 9.50 | 11 | 117491 | 640 | 46567920 |
Actinomycosis | 11.58 | 9.50 | 14 | 117488 | 1074 | 46567486 |
Forced vital capacity abnormal | 11.58 | 9.50 | 4 | 117498 | 29 | 46568531 |
Palatal swelling | 11.57 | 9.50 | 5 | 117497 | 70 | 46568490 |
Anaemia | 11.55 | 9.50 | 526 | 116976 | 255253 | 46313307 |
Lip pain | 11.53 | 9.50 | 18 | 117484 | 1760 | 46566800 |
Cataract | 11.52 | 9.50 | 67 | 117435 | 45348 | 46523212 |
Injection site urticaria | 11.52 | 9.50 | 8 | 117494 | 11959 | 46556601 |
Laryngeal dyspnoea | 11.48 | 9.50 | 6 | 117496 | 131 | 46568429 |
Bone pain | 11.46 | 9.50 | 70 | 117432 | 46820 | 46521740 |
Sweat discolouration | 11.37 | 9.50 | 3 | 117499 | 7 | 46568553 |
Status epilepticus | 11.34 | 9.50 | 67 | 117435 | 13912 | 46554648 |
Inhibitory drug interaction | 11.31 | 9.50 | 19 | 117483 | 1976 | 46566584 |
Liver function test abnormal | 11.29 | 9.50 | 172 | 117330 | 46315 | 46522245 |
Tooth discolouration | 11.29 | 9.50 | 12 | 117490 | 800 | 46567760 |
Serotonin syndrome | 11.18 | 9.50 | 28 | 117474 | 24192 | 46544368 |
Macroglossia | 11.16 | 9.50 | 10 | 117492 | 540 | 46568020 |
Blood test abnormal | 11.13 | 9.50 | 5 | 117497 | 9515 | 46559045 |
Non-alcoholic steatohepatitis | 11.11 | 9.50 | 16 | 117486 | 1456 | 46567104 |
Congenital tricuspid valve incompetence | 11.09 | 9.50 | 5 | 117497 | 78 | 46568482 |
Septic pulmonary embolism | 11.03 | 9.50 | 4 | 117498 | 34 | 46568526 |
Uveitis | 10.98 | 9.50 | 4 | 117498 | 8637 | 46559923 |
Muscle necrosis | 10.94 | 9.50 | 10 | 117492 | 554 | 46568006 |
Gingival swelling | 10.94 | 9.50 | 28 | 117474 | 3922 | 46564638 |
Ureteric dilatation | 10.93 | 9.50 | 4 | 117498 | 35 | 46568525 |
Infusion site nodule | 10.93 | 9.50 | 13 | 117489 | 981 | 46567579 |
Reaction to excipient | 10.92 | 9.50 | 14 | 117488 | 1140 | 46567420 |
Weight decreased | 10.91 | 9.50 | 427 | 117075 | 210422 | 46358138 |
Glycosylated haemoglobin increased | 10.83 | 9.50 | 7 | 117495 | 10869 | 46557691 |
Veillonella infection | 10.83 | 9.50 | 4 | 117498 | 36 | 46568524 |
Blood catecholamines abnormal | 10.83 | 9.50 | 3 | 117499 | 9 | 46568551 |
Delusion of grandeur | 10.83 | 9.50 | 6 | 117496 | 148 | 46568412 |
Mucosal discolouration | 10.81 | 9.50 | 9 | 117493 | 440 | 46568120 |
Abdominal wall haematoma | 10.80 | 9.50 | 23 | 117479 | 2858 | 46565702 |
Cerebral infarction | 10.80 | 9.50 | 27 | 117475 | 23339 | 46545221 |
Genital erosion | 10.75 | 9.50 | 6 | 117496 | 150 | 46568410 |
Delayed delivery | 10.73 | 9.50 | 4 | 117498 | 37 | 46568523 |
Pneumonia aspiration | 10.73 | 9.50 | 42 | 117460 | 31563 | 46536997 |
Tongue pruritus | 10.67 | 9.50 | 9 | 117493 | 448 | 46568112 |
Tongue exfoliation | 10.65 | 9.50 | 5 | 117497 | 86 | 46568474 |
Subacute hepatic failure | 10.61 | 9.50 | 6 | 117496 | 154 | 46568406 |
Impaired healing | 10.55 | 9.50 | 52 | 117450 | 36691 | 46531869 |
Foot deformity | 10.55 | 9.50 | 14 | 117488 | 15411 | 46553149 |
Hypothyroidism | 10.41 | 9.50 | 42 | 117460 | 31296 | 46537264 |
Factor V inhibition | 10.37 | 9.50 | 6 | 117496 | 161 | 46568399 |
Lip erythema | 10.29 | 9.50 | 5 | 117497 | 93 | 46568467 |
Poor quality sleep | 10.27 | 9.50 | 14 | 117488 | 15239 | 46553321 |
Pneumocystis jirovecii pneumonia | 10.26 | 9.50 | 14 | 117488 | 15234 | 46553326 |
Flank pain | 10.26 | 9.50 | 58 | 117444 | 11855 | 46556705 |
Biliary dyskinesia | 10.24 | 9.50 | 22 | 117480 | 2751 | 46565809 |
Polyneuropathy | 10.23 | 9.50 | 57 | 117445 | 11587 | 46556973 |
Behaviour disorder | 10.23 | 9.50 | 18 | 117484 | 1943 | 46566617 |
Maternal exposure during breast feeding | 10.15 | 9.50 | 22 | 117480 | 2767 | 46565793 |
Psoriatic arthropathy | 10.15 | 9.50 | 52 | 117450 | 36327 | 46532233 |
Rheumatoid nodule | 10.14 | 9.50 | 5 | 117497 | 9015 | 46559545 |
Stomatococcal infection | 10.10 | 9.50 | 5 | 117497 | 97 | 46568463 |
Monoclonal gammopathy | 10.04 | 9.50 | 10 | 117492 | 617 | 46567943 |
Foetal distress syndrome | 10.02 | 9.50 | 14 | 117488 | 1239 | 46567321 |
Palmar-plantar erythrodysaesthesia syndrome | 9.95 | 9.50 | 23 | 117479 | 20428 | 46548132 |
Somnolence | 9.93 | 9.50 | 309 | 117193 | 156212 | 46412348 |
Sleep disorder | 9.87 | 9.50 | 73 | 117429 | 46722 | 46521838 |
Glomerulonephritis acute | 9.81 | 9.50 | 4 | 117498 | 48 | 46568512 |
Ureteric obstruction | 9.78 | 9.50 | 17 | 117485 | 1817 | 46566743 |
Pruritus genital | 9.78 | 9.50 | 10 | 117492 | 637 | 46567923 |
Upper respiratory tract infection | 9.77 | 9.50 | 219 | 117283 | 63337 | 46505223 |
Rhabdomyolysis | 9.77 | 9.50 | 154 | 117348 | 41755 | 46526805 |
Therapy non-responder | 9.77 | 9.50 | 62 | 117440 | 41090 | 46527470 |
Pneumopericardium | 9.74 | 9.50 | 4 | 117498 | 49 | 46568511 |
Genital prolapse | 9.66 | 9.50 | 4 | 117498 | 50 | 46568510 |
Respiratory gas exchange disorder | 9.66 | 9.50 | 8 | 117494 | 388 | 46568172 |
Helicobacter test positive | 9.64 | 9.50 | 8 | 117494 | 389 | 46568171 |
Incorrect dose administered | 9.63 | 9.50 | 71 | 117431 | 45479 | 46523081 |
Intentional self-injury | 9.62 | 9.50 | 30 | 117472 | 24136 | 46544424 |
Coagulation factor deficiency | 9.62 | 9.50 | 3 | 117499 | 15 | 46568545 |
Gamma-glutamyltransferase increased | 9.55 | 9.50 | 122 | 117380 | 31618 | 46536942 |
Nasopharyngitis | 9.53 | 9.50 | 305 | 117197 | 153693 | 46414867 |
Hemianopia homonymous | 9.52 | 9.50 | 10 | 117492 | 657 | 46567903 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug reaction with eosinophilia and systemic symptoms | 540.63 | 9.84 | 520 | 82432 | 27968 | 29841558 |
Anaphylactic shock | 466.22 | 9.84 | 353 | 82599 | 13640 | 29855886 |
Pruritus | 451.31 | 9.84 | 1004 | 81948 | 117200 | 29752326 |
Rash maculo-papular | 437.59 | 9.84 | 440 | 82512 | 24978 | 29844548 |
Urticaria | 384.88 | 9.84 | 604 | 82348 | 54002 | 29815524 |
Cholestasis | 295.58 | 9.84 | 355 | 82597 | 24595 | 29844931 |
Hepatocellular injury | 289.68 | 9.84 | 355 | 82597 | 25116 | 29844410 |
Anaphylactic reaction | 277.08 | 9.84 | 364 | 82588 | 27618 | 29841908 |
Erythema | 266.49 | 9.84 | 632 | 82320 | 76819 | 29792707 |
Rash | 266.06 | 9.84 | 1143 | 81809 | 190746 | 29678780 |
Acute generalised exanthematous pustulosis | 258.27 | 9.84 | 178 | 82774 | 5920 | 29863606 |
Eosinophilia | 257.08 | 9.84 | 312 | 82640 | 21848 | 29847678 |
Drug hypersensitivity | 239.88 | 9.84 | 563 | 82389 | 67956 | 29801570 |
Meningitis aseptic | 208.83 | 9.84 | 110 | 82842 | 2212 | 29867314 |
Hepatitis cholestatic | 207.28 | 9.84 | 173 | 82779 | 7699 | 29861827 |
Death | 207.26 | 9.84 | 425 | 82527 | 356858 | 29512668 |
Lip oedema | 204.10 | 9.84 | 107 | 82845 | 2130 | 29867396 |
Drug-induced liver injury | 198.68 | 9.84 | 269 | 82683 | 21005 | 29848521 |
Angioedema | 197.31 | 9.84 | 347 | 82605 | 34037 | 29835489 |
Kounis syndrome | 181.67 | 9.84 | 90 | 82862 | 1583 | 29867943 |
Completed suicide | 156.76 | 9.84 | 41 | 82911 | 99451 | 29770075 |
Mixed liver injury | 144.83 | 9.84 | 82 | 82870 | 1911 | 29867615 |
Acute kidney injury | 135.50 | 9.84 | 1252 | 81700 | 272590 | 29596936 |
Toxic epidermal necrolysis | 135.38 | 9.84 | 205 | 82747 | 17735 | 29851791 |
Face oedema | 132.08 | 9.84 | 160 | 82792 | 11174 | 29858352 |
Type I hypersensitivity | 130.39 | 9.84 | 60 | 82892 | 888 | 29868638 |
Stevens-Johnson syndrome | 123.21 | 9.84 | 194 | 82758 | 17362 | 29852164 |
Lip swelling | 117.22 | 9.84 | 160 | 82792 | 12584 | 29856942 |
Toxicity to various agents | 109.03 | 9.84 | 203 | 82749 | 176980 | 29692546 |
Toxic skin eruption | 105.43 | 9.84 | 141 | 82811 | 10874 | 29858652 |
Type IV hypersensitivity reaction | 99.32 | 9.84 | 53 | 82899 | 1095 | 29868431 |
Hepatitis acute | 97.60 | 9.84 | 109 | 82843 | 6974 | 29862552 |
Jaundice | 93.58 | 9.84 | 248 | 82704 | 32238 | 29837288 |
Enterocolitis haemorrhagic | 89.89 | 9.84 | 47 | 82905 | 930 | 29868596 |
Hypersensitivity | 89.74 | 9.84 | 341 | 82611 | 53687 | 29815839 |
Hepatitis | 89.59 | 9.84 | 194 | 82758 | 22162 | 29847364 |
Fixed eruption | 86.80 | 9.84 | 49 | 82903 | 1135 | 29868391 |
Clostridium difficile colitis | 86.70 | 9.84 | 139 | 82813 | 12629 | 29856897 |
Rash erythematous | 84.51 | 9.84 | 190 | 82762 | 22262 | 29847264 |
Pyrexia | 81.47 | 9.84 | 1204 | 81748 | 293285 | 29576241 |
Myocardial infarction | 78.92 | 9.84 | 142 | 82810 | 125483 | 29744043 |
Dermatitis exfoliative generalised | 78.55 | 9.84 | 64 | 82888 | 2751 | 29866775 |
Erythema multiforme | 77.62 | 9.84 | 103 | 82849 | 7882 | 29861644 |
Wound closure | 76.26 | 9.84 | 24 | 82928 | 111 | 29869415 |
Idiosyncratic drug reaction | 76.22 | 9.84 | 34 | 82918 | 466 | 29869060 |
Fall | 74.80 | 9.84 | 256 | 82696 | 181616 | 29687910 |
Osteotomy | 74.09 | 9.84 | 24 | 82928 | 124 | 29869402 |
Tongue oedema | 72.97 | 9.84 | 61 | 82891 | 2719 | 29866807 |
Documented hypersensitivity to administered product | 72.44 | 9.84 | 26 | 82926 | 192 | 29869334 |
Eyelid oedema | 68.42 | 9.84 | 77 | 82875 | 4968 | 29864558 |
Cardiac failure congestive | 67.05 | 9.84 | 81 | 82871 | 84326 | 29785200 |
Crystalluria | 64.72 | 9.84 | 28 | 82924 | 355 | 29869171 |
Rash morbilliform | 63.82 | 9.84 | 54 | 82898 | 2448 | 29867078 |
Liver injury | 62.04 | 9.84 | 118 | 82834 | 12282 | 29857244 |
Jaundice cholestatic | 60.93 | 9.84 | 69 | 82883 | 4482 | 29865044 |
Drug abuse | 59.80 | 9.84 | 84 | 82868 | 81988 | 29787538 |
Tubulointerstitial nephritis | 58.17 | 9.84 | 143 | 82809 | 17748 | 29851778 |
Bronchospasm | 57.53 | 9.84 | 103 | 82849 | 10235 | 29859291 |
Cholestatic liver injury | 56.88 | 9.84 | 42 | 82910 | 1559 | 29867967 |
Rash pruritic | 55.79 | 9.84 | 163 | 82789 | 22409 | 29847117 |
Fatigue | 54.10 | 9.84 | 598 | 82354 | 320075 | 29549451 |
Malignant neoplasm progression | 53.65 | 9.84 | 73 | 82879 | 72214 | 29797312 |
Cerebrovascular accident | 53.61 | 9.84 | 93 | 82859 | 83384 | 29786142 |
Serum sickness-like reaction | 52.14 | 9.84 | 17 | 82935 | 90 | 29869436 |
Palatal oedema | 51.46 | 9.84 | 30 | 82922 | 740 | 29868786 |
Rash pustular | 51.11 | 9.84 | 66 | 82886 | 4917 | 29864609 |
Acute psychosis | 50.98 | 9.84 | 42 | 82910 | 1834 | 29867692 |
Faeces pale | 50.80 | 9.84 | 38 | 82914 | 1439 | 29868087 |
Swelling face | 49.44 | 9.84 | 150 | 82802 | 21054 | 29848472 |
Agranulocytosis | 48.18 | 9.84 | 152 | 82800 | 21790 | 29847736 |
Purpura | 46.38 | 9.84 | 92 | 82860 | 9875 | 29859651 |
Swollen tongue | 45.62 | 9.84 | 108 | 82844 | 13084 | 29856442 |
Disease progression | 45.17 | 9.84 | 96 | 82856 | 79778 | 29789748 |
Rash macular | 42.71 | 9.84 | 91 | 82861 | 10276 | 29859250 |
Clostridium difficile infection | 41.94 | 9.84 | 117 | 82835 | 15666 | 29853860 |
Rheumatoid arthritis | 41.45 | 9.84 | 32 | 82920 | 41165 | 29828361 |
Hypersensitivity vasculitis | 40.85 | 9.84 | 51 | 82901 | 3672 | 29865854 |
Mouth swelling | 39.74 | 9.84 | 34 | 82918 | 1565 | 29867961 |
Lower respiratory tract infection | 39.00 | 9.84 | 162 | 82790 | 26552 | 29842974 |
Henoch-Schonlein purpura | 37.92 | 9.84 | 32 | 82920 | 1445 | 29868081 |
Dermatitis bullous | 36.80 | 9.84 | 63 | 82889 | 6041 | 29863485 |
Sensation of foreign body | 36.21 | 9.84 | 31 | 82921 | 1428 | 29868098 |
Chromaturia | 36.07 | 9.84 | 102 | 82850 | 13763 | 29855763 |
Premature baby | 36.07 | 9.84 | 115 | 82837 | 16576 | 29852950 |
Weight increased | 35.29 | 9.84 | 99 | 82853 | 74814 | 29794712 |
Vomiting | 34.81 | 9.84 | 825 | 82127 | 218993 | 29650533 |
Helicobacter gastritis | 34.21 | 9.84 | 24 | 82928 | 821 | 29868705 |
Laryngeal oedema | 34.15 | 9.84 | 44 | 82908 | 3270 | 29866256 |
Therapeutic product effect decreased | 34.11 | 9.84 | 19 | 82933 | 29057 | 29840469 |
Inflammatory marker increased | 33.91 | 9.84 | 43 | 82909 | 3145 | 29866381 |
Tooth disorder | 33.87 | 9.84 | 77 | 82875 | 9084 | 29860442 |
Conjunctivitis | 33.86 | 9.84 | 71 | 82881 | 7929 | 29861597 |
Mononucleosis syndrome | 33.31 | 9.84 | 11 | 82941 | 61 | 29869465 |
Platelet count decreased | 33.18 | 9.84 | 166 | 82786 | 105963 | 29763563 |
Dizziness | 32.95 | 9.84 | 363 | 82589 | 194546 | 29674980 |
Hypertension | 32.91 | 9.84 | 199 | 82753 | 121155 | 29748371 |
Cerebral infarction | 32.76 | 9.84 | 16 | 82936 | 26357 | 29843169 |
Cell death | 32.58 | 9.84 | 36 | 82916 | 2275 | 29867251 |
Injection site pain | 32.51 | 9.84 | 22 | 82930 | 30288 | 29839238 |
Blood glucose increased | 32.29 | 9.84 | 77 | 82875 | 61453 | 29808073 |
Helicobacter infection | 32.07 | 9.84 | 34 | 82918 | 2050 | 29867476 |
Drug eruption | 31.90 | 9.84 | 114 | 82838 | 17412 | 29852114 |
Sinusitis | 31.86 | 9.84 | 179 | 82773 | 33166 | 29836360 |
Tooth demineralisation | 31.76 | 9.84 | 7 | 82945 | 3 | 29869523 |
Crystal nephropathy | 31.10 | 9.84 | 17 | 82935 | 369 | 29869157 |
Prothrombin time shortened | 30.62 | 9.84 | 29 | 82923 | 1526 | 29868000 |
Coronary artery disease | 30.45 | 9.84 | 57 | 82895 | 49655 | 29819871 |
Dermatitis allergic | 30.20 | 9.84 | 56 | 82896 | 5716 | 29863810 |
Eosinophilic pleural effusion | 30.02 | 9.84 | 14 | 82938 | 214 | 29869312 |
Laryngeal dyspnoea | 29.91 | 9.84 | 10 | 82942 | 58 | 29869468 |
Depression | 29.69 | 9.84 | 139 | 82813 | 90298 | 29779228 |
Pathogen resistance | 29.24 | 9.84 | 69 | 82883 | 8341 | 29861185 |
Skin test positive | 28.96 | 9.84 | 16 | 82936 | 355 | 29869171 |
Haemoglobin decreased | 28.93 | 9.84 | 191 | 82761 | 113907 | 29755619 |
Blood creatine phosphokinase increased | 28.92 | 9.84 | 48 | 82904 | 43800 | 29825726 |
Rash vesicular | 28.89 | 9.84 | 35 | 82917 | 2443 | 29867083 |
Wheezing | 28.85 | 9.84 | 165 | 82787 | 30773 | 29838753 |
Epstein-Barr virus infection reactivation | 28.79 | 9.84 | 14 | 82938 | 236 | 29869290 |
Cheilitis | 28.17 | 9.84 | 33 | 82919 | 2223 | 29867303 |
Aortitis | 28.03 | 9.84 | 12 | 82940 | 148 | 29869378 |
Oxygen saturation immeasurable | 28.03 | 9.84 | 9 | 82943 | 45 | 29869481 |
Rash papular | 27.99 | 9.84 | 69 | 82883 | 8576 | 29860950 |
Tooth infection | 27.96 | 9.84 | 51 | 82901 | 5140 | 29864386 |
Tachycardia foetal | 27.84 | 9.84 | 15 | 82937 | 316 | 29869210 |
Malaise | 27.74 | 9.84 | 631 | 82321 | 166331 | 29703195 |
Drug intolerance | 27.68 | 9.84 | 52 | 82900 | 45239 | 29824287 |
Factitious disorder | 27.55 | 9.84 | 9 | 82943 | 48 | 29869478 |
Sensitisation | 27.26 | 9.84 | 12 | 82940 | 159 | 29869367 |
Conjunctival irritation | 26.98 | 9.84 | 11 | 82941 | 119 | 29869407 |
Otospondylomegaepiphyseal dysplasia | 26.81 | 9.84 | 11 | 82941 | 121 | 29869405 |
Periorbital oedema | 26.50 | 9.84 | 39 | 82913 | 3287 | 29866239 |
Aphthous ulcer | 25.30 | 9.84 | 43 | 82909 | 4098 | 29865428 |
Pain | 25.16 | 9.84 | 332 | 82620 | 172309 | 29697217 |
Angina pectoris | 24.86 | 9.84 | 27 | 82925 | 29491 | 29840035 |
White blood cell count decreased | 24.71 | 9.84 | 134 | 82818 | 83813 | 29785713 |
Wrong technique in product usage process | 24.61 | 9.84 | 30 | 82922 | 31125 | 29838401 |
Deficiency of bile secretion | 24.60 | 9.84 | 7 | 82945 | 21 | 29869505 |
Hypersensitivity myocarditis | 24.56 | 9.84 | 9 | 82943 | 71 | 29869455 |
Rash scarlatiniform | 24.54 | 9.84 | 10 | 82942 | 108 | 29869418 |
Product dose omission issue | 24.44 | 9.84 | 151 | 82801 | 91480 | 29778046 |
Malignant mesenteric neoplasm | 24.28 | 9.84 | 8 | 82944 | 44 | 29869482 |
Mental status changes | 24.07 | 9.84 | 41 | 82911 | 37038 | 29832488 |
Loss of personal independence in daily activities | 23.95 | 9.84 | 15 | 82937 | 21520 | 29848006 |
Macroglossia | 23.92 | 9.84 | 12 | 82940 | 217 | 29869309 |
Ureteral disorder | 23.36 | 9.84 | 11 | 82941 | 172 | 29869354 |
Heart rate decreased | 22.83 | 9.84 | 15 | 82937 | 20979 | 29848547 |
Foetal disorder | 22.79 | 9.84 | 17 | 82935 | 641 | 29868885 |
Escherichia infection | 22.76 | 9.84 | 53 | 82899 | 6352 | 29863174 |
Irregular breathing | 22.75 | 9.84 | 10 | 82942 | 132 | 29869394 |
Infusion related reaction | 22.71 | 9.84 | 49 | 82903 | 40515 | 29829011 |
Hyperaemia | 22.61 | 9.84 | 20 | 82932 | 963 | 29868563 |
Foetal exposure during pregnancy | 22.51 | 9.84 | 177 | 82775 | 36694 | 29832832 |
Acute hepatic failure | 22.45 | 9.84 | 78 | 82874 | 11749 | 29857777 |
Pain in extremity | 22.05 | 9.84 | 197 | 82755 | 110024 | 29759502 |
Conjunctival hyperaemia | 21.66 | 9.84 | 29 | 82923 | 2238 | 29867288 |
Gut fermentation syndrome | 21.60 | 9.84 | 6 | 82946 | 16 | 29869510 |
Diarrhoea | 21.19 | 9.84 | 1129 | 81823 | 332974 | 29536552 |
Attention-seeking behaviour | 21.17 | 9.84 | 7 | 82945 | 39 | 29869487 |
Penile erythema | 21.14 | 9.84 | 10 | 82942 | 158 | 29869368 |
Hyperbilirubinaemia | 21.12 | 9.84 | 98 | 82854 | 16844 | 29852682 |
Jejunal ulcer perforation | 21.11 | 9.84 | 8 | 82944 | 70 | 29869456 |
Neutropenia neonatal | 21.06 | 9.84 | 15 | 82937 | 526 | 29869000 |
Deep vein thrombosis | 21.04 | 9.84 | 91 | 82861 | 60410 | 29809116 |
Asthenia | 21.02 | 9.84 | 460 | 82492 | 220830 | 29648696 |
Intentional product misuse | 21.01 | 9.84 | 40 | 82912 | 34627 | 29834899 |
Ear infection | 20.92 | 9.84 | 56 | 82896 | 7318 | 29862208 |
Mite allergy | 20.84 | 9.84 | 11 | 82941 | 222 | 29869304 |
Metastases to stomach | 20.72 | 9.84 | 8 | 82944 | 74 | 29869452 |
Cardio-respiratory arrest | 20.67 | 9.84 | 85 | 82867 | 57221 | 29812305 |
Alice in wonderland syndrome | 20.61 | 9.84 | 6 | 82946 | 20 | 29869506 |
Dyspnoea | 20.49 | 9.84 | 1123 | 81829 | 332172 | 29537354 |
Choluria | 20.49 | 9.84 | 10 | 82942 | 170 | 29869356 |
Dental operation | 20.27 | 9.84 | 13 | 82939 | 382 | 29869144 |
Erysipelas | 20.14 | 9.84 | 41 | 82911 | 4483 | 29865043 |
Dysbiosis | 20.00 | 9.84 | 13 | 82939 | 391 | 29869135 |
Ultrasound liver abnormal | 19.94 | 9.84 | 9 | 82943 | 127 | 29869399 |
Skin exfoliation | 19.93 | 9.84 | 121 | 82831 | 23051 | 29846475 |
Seizure | 19.70 | 9.84 | 176 | 82776 | 98299 | 29771227 |
Bradycardia | 19.61 | 9.84 | 104 | 82848 | 65422 | 29804104 |
Pharyngeal erythema | 19.50 | 9.84 | 14 | 82938 | 497 | 29869029 |
Dermatomyositis | 19.42 | 9.84 | 19 | 82933 | 1041 | 29868485 |
Transaminases increased | 19.24 | 9.84 | 121 | 82831 | 23336 | 29846190 |
Hyperleukocytosis | 19.21 | 9.84 | 23 | 82929 | 1586 | 29867940 |
Oropharyngeal pain | 19.19 | 9.84 | 140 | 82812 | 28356 | 29841170 |
Haematocrit decreased | 18.97 | 9.84 | 35 | 82917 | 30664 | 29838862 |
Skin reaction | 18.96 | 9.84 | 40 | 82912 | 4485 | 29865041 |
Odynophagia | 18.95 | 9.84 | 40 | 82912 | 4487 | 29865039 |
Headache | 18.76 | 9.84 | 374 | 82578 | 181932 | 29687594 |
Genital erythema | 18.71 | 9.84 | 9 | 82943 | 148 | 29869378 |
Eastern Cooperative Oncology Group performance status | 18.68 | 9.84 | 6 | 82946 | 30 | 29869496 |
Omental necrosis | 18.68 | 9.84 | 6 | 82946 | 30 | 29869496 |
Procalcitonin increased | 18.57 | 9.84 | 19 | 82933 | 1099 | 29868427 |
Ischaemic stroke | 18.57 | 9.84 | 11 | 82941 | 16264 | 29853262 |
Drug dependence | 18.46 | 9.84 | 19 | 82933 | 21276 | 29848250 |
Breath sounds | 18.37 | 9.84 | 5 | 82947 | 12 | 29869514 |
Substance-induced mood disorder | 18.37 | 9.84 | 5 | 82947 | 12 | 29869514 |
Constipation | 18.36 | 9.84 | 212 | 82740 | 112694 | 29756832 |
Enterocolitis | 18.19 | 9.84 | 50 | 82902 | 6637 | 29862889 |
Morganella infection | 18.12 | 9.84 | 12 | 82940 | 373 | 29869153 |
Tissue infiltration | 18.01 | 9.84 | 7 | 82945 | 66 | 29869460 |
Orthostatic hypotension | 17.99 | 9.84 | 24 | 82928 | 23955 | 29845571 |
Skin oedema | 17.96 | 9.84 | 14 | 82938 | 564 | 29868962 |
Bone disorder | 17.93 | 9.84 | 50 | 82902 | 6691 | 29862835 |
Eosinophilic pneumonia acute | 17.93 | 9.84 | 13 | 82939 | 469 | 29869057 |
Mycotic allergy | 17.68 | 9.84 | 9 | 82943 | 168 | 29869358 |
Linear IgA disease | 17.66 | 9.84 | 22 | 82930 | 1580 | 29867946 |
Faeces discoloured | 17.62 | 9.84 | 81 | 82871 | 13865 | 29855661 |
Off label use | 17.37 | 9.84 | 542 | 82410 | 248748 | 29620778 |
Lichenoid keratosis | 17.33 | 9.84 | 25 | 82927 | 2069 | 29867457 |
Pharyngeal oedema | 17.22 | 9.84 | 48 | 82904 | 6423 | 29863103 |
Papule | 17.15 | 9.84 | 31 | 82921 | 3102 | 29866424 |
Hyperglycaemia | 16.95 | 9.84 | 46 | 82906 | 35154 | 29834372 |
Blood pressure increased | 16.93 | 9.84 | 123 | 82829 | 71805 | 29797721 |
Spinal muscular atrophy | 16.90 | 9.84 | 9 | 82943 | 185 | 29869341 |
Plica syndrome | 16.81 | 9.84 | 4 | 82948 | 4 | 29869522 |
Genital cyst | 16.81 | 9.84 | 4 | 82948 | 4 | 29869522 |
Food intolerance | 16.77 | 9.84 | 18 | 82934 | 1101 | 29868425 |
Neutrophil count decreased | 16.57 | 9.84 | 61 | 82891 | 42393 | 29827133 |
Pharyngitis | 16.51 | 9.84 | 49 | 82903 | 6793 | 29862733 |
Unresponsive to stimuli | 16.43 | 9.84 | 30 | 82922 | 26389 | 29843137 |
Coagulation factor decreased | 16.38 | 9.84 | 7 | 82945 | 86 | 29869440 |
Macule | 16.35 | 9.84 | 16 | 82936 | 877 | 29868649 |
Vanishing bile duct syndrome | 16.19 | 9.84 | 14 | 82938 | 654 | 29868872 |
Tachypnoea | 16.13 | 9.84 | 83 | 82869 | 14869 | 29854657 |
Metastases to heart | 16.13 | 9.84 | 8 | 82944 | 141 | 29869385 |
Laryngeal discomfort | 15.98 | 9.84 | 8 | 82944 | 144 | 29869382 |
Hypocoagulable state | 15.93 | 9.84 | 16 | 82936 | 905 | 29868621 |
Hypertransaminasaemia | 15.88 | 9.84 | 34 | 82918 | 3851 | 29865675 |
Blood creatinine increased | 15.87 | 9.84 | 169 | 82783 | 91206 | 29778320 |
Cerebral haemorrhage | 15.82 | 9.84 | 43 | 82909 | 32844 | 29836682 |
Diabetes mellitus | 15.79 | 9.84 | 61 | 82891 | 41804 | 29827722 |
Melanocytic hyperplasia | 15.54 | 9.84 | 4 | 82948 | 7 | 29869519 |
Tongue eruption | 15.54 | 9.84 | 4 | 82948 | 7 | 29869519 |
Drug ineffective | 15.47 | 9.84 | 778 | 82174 | 339609 | 29529917 |
Synovitis | 15.45 | 9.84 | 4 | 82948 | 9779 | 29859747 |
Granulomatous dermatitis | 15.40 | 9.84 | 9 | 82943 | 223 | 29869303 |
Maple syrup disease | 15.20 | 9.84 | 4 | 82948 | 8 | 29869518 |
Ototoxicity | 15.12 | 9.84 | 19 | 82933 | 1377 | 29868149 |
Rectal polyp | 14.98 | 9.84 | 13 | 82939 | 610 | 29868916 |
Inappropriate schedule of product administration | 14.91 | 9.84 | 58 | 82894 | 39670 | 29829856 |
Sedation | 14.90 | 9.84 | 14 | 82938 | 16359 | 29853167 |
Dermatitis | 14.85 | 9.84 | 53 | 82899 | 8089 | 29861437 |
Maternal exposure during pregnancy | 14.83 | 9.84 | 33 | 82919 | 3838 | 29865688 |
Antinuclear antibody negative | 14.81 | 9.84 | 5 | 82947 | 30 | 29869496 |
Anaemia | 14.77 | 9.84 | 451 | 82501 | 207541 | 29661985 |
Drug withdrawal syndrome | 14.69 | 9.84 | 20 | 82932 | 19789 | 29849737 |
Toxocariasis | 14.68 | 9.84 | 3 | 82949 | 0 | 29869526 |
Intercostal neuralgia | 14.68 | 9.84 | 3 | 82949 | 0 | 29869526 |
Hepatic function abnormal | 14.63 | 9.84 | 63 | 82889 | 41882 | 29827644 |
Tooth abscess | 14.61 | 9.84 | 39 | 82913 | 5087 | 29864439 |
Conjunctivitis allergic | 14.60 | 9.84 | 12 | 82940 | 522 | 29869004 |
Peritonitis | 14.46 | 9.84 | 23 | 82929 | 21352 | 29848174 |
Ascites | 14.42 | 9.84 | 51 | 82901 | 35870 | 29833656 |
Cutaneous vasculitis | 14.39 | 9.84 | 28 | 82924 | 2963 | 29866563 |
Dermatosis | 14.33 | 9.84 | 9 | 82943 | 255 | 29869271 |
Prostate cancer | 14.20 | 9.84 | 28 | 82924 | 23929 | 29845597 |
Cardiac ventricular disorder | 14.18 | 9.84 | 8 | 82944 | 185 | 29869341 |
Low birth weight baby | 14.17 | 9.84 | 43 | 82909 | 6033 | 29863493 |
Hallucinations, mixed | 14.15 | 9.84 | 25 | 82927 | 2458 | 29867068 |
Biliary sepsis | 14.13 | 9.84 | 13 | 82939 | 659 | 29868867 |
Insomnia | 14.12 | 9.84 | 178 | 82774 | 93158 | 29776368 |
Respiratory tract infection bacterial | 14.09 | 9.84 | 12 | 82940 | 549 | 29868977 |
Colon cancer | 14.05 | 9.84 | 3 | 82949 | 8369 | 29861157 |
Interleukin-2 receptor increased | 14.03 | 9.84 | 7 | 82945 | 125 | 29869401 |
Anal abscess | 13.88 | 9.84 | 38 | 82914 | 5031 | 29864495 |
Gingivitis | 13.88 | 9.84 | 28 | 82924 | 3042 | 29866484 |
Balanoposthitis | 13.87 | 9.84 | 16 | 82936 | 1060 | 29868466 |
Nocardiosis | 13.85 | 9.84 | 30 | 82922 | 3425 | 29866101 |
Exostosis of external ear canal | 13.82 | 9.84 | 4 | 82948 | 13 | 29869513 |
Osteomyelitis salmonella | 13.81 | 9.84 | 5 | 82947 | 38 | 29869488 |
Mucous stools | 13.77 | 9.84 | 15 | 82937 | 933 | 29868593 |
Dysentery | 13.66 | 9.84 | 8 | 82944 | 199 | 29869327 |
Hepatitis C | 13.61 | 9.84 | 10 | 82942 | 13195 | 29856331 |
Infusion site induration | 13.59 | 9.84 | 8 | 82944 | 201 | 29869325 |
Leukocytosis | 13.55 | 9.84 | 104 | 82848 | 21398 | 29848128 |
Respiratory arrest | 13.52 | 9.84 | 39 | 82913 | 29219 | 29840307 |
Overdose | 13.46 | 9.84 | 159 | 82793 | 84178 | 29785348 |
Device malfunction | 13.43 | 9.84 | 3 | 82949 | 8108 | 29861418 |
Vesicoureteric reflux | 13.41 | 9.84 | 7 | 82945 | 138 | 29869388 |
Tongue discolouration | 13.41 | 9.84 | 16 | 82936 | 1099 | 29868427 |
Orbital myositis | 13.40 | 9.84 | 6 | 82946 | 83 | 29869443 |
Pulmonary valve disease | 13.34 | 9.84 | 6 | 82946 | 84 | 29869442 |
Spirometry abnormal | 13.33 | 9.84 | 9 | 82943 | 289 | 29869237 |
Otitis media acute | 13.27 | 9.84 | 10 | 82942 | 383 | 29869143 |
Superinfection bacterial | 13.26 | 9.84 | 11 | 82941 | 485 | 29869041 |
Lymphadenopathy | 13.25 | 9.84 | 114 | 82838 | 24262 | 29845264 |
Therapeutic response decreased | 13.14 | 9.84 | 30 | 82922 | 24319 | 29845207 |
Injection site swelling | 13.10 | 9.84 | 4 | 82948 | 8776 | 29860750 |
Ear swelling | 13.09 | 9.84 | 10 | 82942 | 391 | 29869135 |
Endocarditis candida | 13.03 | 9.84 | 6 | 82946 | 89 | 29869437 |
Blister | 13.01 | 9.84 | 100 | 82852 | 20583 | 29848943 |
Blood urea increased | 12.97 | 9.84 | 44 | 82908 | 31337 | 29838189 |
Dehydration | 12.82 | 9.84 | 253 | 82699 | 123286 | 29746240 |
Erythema annulare | 12.80 | 9.84 | 4 | 82948 | 18 | 29869508 |
Underdose | 12.77 | 9.84 | 9 | 82943 | 12132 | 29857394 |
Localised oedema | 12.67 | 9.84 | 27 | 82925 | 3049 | 29866477 |
Blood pressure fluctuation | 12.65 | 9.84 | 18 | 82934 | 17485 | 29852041 |
Accessory auricle | 12.62 | 9.84 | 4 | 82948 | 19 | 29869507 |
Human herpesvirus 6 infection reactivation | 12.62 | 9.84 | 4 | 82948 | 19 | 29869507 |
Rebound acid hypersecretion | 12.61 | 9.84 | 5 | 82947 | 50 | 29869476 |
Red blood cell sedimentation rate decreased | 12.61 | 9.84 | 5 | 82947 | 50 | 29869476 |
Back pain | 12.58 | 9.84 | 204 | 82748 | 102392 | 29767134 |
Abdominal wall haematoma | 12.55 | 9.84 | 19 | 82933 | 1642 | 29867884 |
Haemolytic anaemia | 12.54 | 9.84 | 58 | 82894 | 9952 | 29859574 |
Cataract | 12.53 | 9.84 | 26 | 82926 | 21809 | 29847717 |
Toothache | 12.52 | 9.84 | 40 | 82912 | 5771 | 29863755 |
Rotavirus infection | 12.40 | 9.84 | 9 | 82943 | 325 | 29869201 |
Injection site erythema | 12.39 | 9.84 | 12 | 82940 | 13822 | 29855704 |
Therapeutic product effect incomplete | 12.31 | 9.84 | 50 | 82902 | 33784 | 29835742 |
Hyperthermia | 12.28 | 9.84 | 58 | 82894 | 10041 | 29859485 |
Infectious mononucleosis | 12.25 | 9.84 | 10 | 82942 | 431 | 29869095 |
Swelling of eyelid | 12.24 | 9.84 | 9 | 82943 | 332 | 29869194 |
Alveolitis | 12.08 | 9.84 | 19 | 82933 | 1698 | 29867828 |
Congenital heart valve disorder | 12.03 | 9.84 | 5 | 82947 | 57 | 29869469 |
Schizophrenia | 12.00 | 9.84 | 5 | 82947 | 9043 | 29860483 |
Periostosis | 11.99 | 9.84 | 4 | 82948 | 23 | 29869503 |
Anal inflammation | 11.98 | 9.84 | 9 | 82943 | 343 | 29869183 |
Cardiac failure | 11.91 | 9.84 | 161 | 82791 | 83257 | 29786269 |
Body fat disorder | 11.88 | 9.84 | 5 | 82947 | 59 | 29869467 |
Hospitalisation | 11.82 | 9.84 | 73 | 82879 | 44246 | 29825280 |
Haematuria | 11.78 | 9.84 | 182 | 82770 | 44652 | 29824874 |
Mobility decreased | 11.76 | 9.84 | 35 | 82917 | 25964 | 29843562 |
Urinary retention | 11.75 | 9.84 | 49 | 82903 | 32868 | 29836658 |
Drug interaction | 11.74 | 9.84 | 670 | 82282 | 198898 | 29670628 |
Oral mucosal blistering | 11.62 | 9.84 | 19 | 82933 | 1754 | 29867772 |
Sense of oppression | 11.60 | 9.84 | 10 | 82942 | 465 | 29869061 |
Psoriatic arthropathy | 11.60 | 9.84 | 16 | 82936 | 15745 | 29853781 |
Hordeolum | 11.48 | 9.84 | 12 | 82940 | 712 | 29868814 |
Interstitial lung disease | 11.42 | 9.84 | 109 | 82843 | 60088 | 29809438 |
Plasma cell myeloma | 11.37 | 9.84 | 94 | 82858 | 53368 | 29816158 |
Ileal perforation | 11.30 | 9.84 | 12 | 82940 | 725 | 29868801 |
Neoplasm malignant | 11.28 | 9.84 | 20 | 82932 | 17794 | 29851732 |
Pyelocaliectasis | 11.27 | 9.84 | 14 | 82938 | 1003 | 29868523 |
Anaphylactoid reaction | 11.18 | 9.84 | 21 | 82931 | 2165 | 29867361 |
Musculoskeletal pain | 11.08 | 9.84 | 46 | 82906 | 30894 | 29838632 |
Mast cell degranulation present | 10.93 | 9.84 | 5 | 82947 | 73 | 29869453 |
Gastrointestinal ischaemia | 10.82 | 9.84 | 7 | 82945 | 209 | 29869317 |
Transplant rejection | 10.82 | 9.84 | 6 | 82946 | 9200 | 29860326 |
Gait disturbance | 10.79 | 9.84 | 144 | 82808 | 74633 | 29794893 |
Ligament sprain | 10.76 | 9.84 | 24 | 82928 | 2796 | 29866730 |
Blood immunoglobulin A increased | 10.74 | 9.84 | 8 | 82944 | 301 | 29869225 |
Hypergammaglobulinaemia | 10.67 | 9.84 | 7 | 82945 | 214 | 29869312 |
Dust allergy | 10.63 | 9.84 | 9 | 82943 | 408 | 29869118 |
Ultrasound scan abnormal | 10.63 | 9.84 | 5 | 82947 | 78 | 29869448 |
Anxiety | 10.59 | 9.84 | 180 | 82772 | 89691 | 29779835 |
Noninfective sialoadenitis | 10.54 | 9.84 | 3 | 82949 | 9 | 29869517 |
Pseudomembranous colitis | 10.48 | 9.84 | 24 | 82928 | 2844 | 29866682 |
Gynaecomastia | 10.47 | 9.84 | 5 | 82947 | 8346 | 29861180 |
Brain abscess | 10.43 | 9.84 | 23 | 82929 | 2658 | 29866868 |
Acute myocardial infarction | 10.41 | 9.84 | 95 | 82857 | 52844 | 29816682 |
Eczema | 10.37 | 9.84 | 68 | 82884 | 13301 | 29856225 |
Blood pressure decreased | 10.37 | 9.84 | 82 | 82870 | 46993 | 29822533 |
Contraindicated product administered | 10.33 | 9.84 | 20 | 82932 | 17211 | 29852315 |
Vascular purpura | 10.31 | 9.84 | 17 | 82935 | 1580 | 29867946 |
Weight decreased | 10.27 | 9.84 | 329 | 82623 | 150592 | 29718934 |
Arthralgia | 10.23 | 9.84 | 292 | 82660 | 135499 | 29734027 |
Multiple sclerosis relapse | 10.22 | 9.84 | 9 | 82943 | 10853 | 29858673 |
Resorption bone increased | 10.19 | 9.84 | 5 | 82947 | 86 | 29869440 |
Epstein-Barr virus antibody positive | 10.19 | 9.84 | 8 | 82944 | 326 | 29869200 |
Pneumococcal sepsis | 10.18 | 9.84 | 11 | 82941 | 678 | 29868848 |
Infusion site swelling | 10.17 | 9.84 | 17 | 82935 | 1599 | 29867927 |
Stomatitis | 10.16 | 9.84 | 61 | 82891 | 37218 | 29832308 |
C-reactive protein increased | 10.13 | 9.84 | 173 | 82779 | 43300 | 29826226 |
Penile swelling | 10.08 | 9.84 | 12 | 82940 | 822 | 29868704 |
Candida infection | 10.07 | 9.84 | 75 | 82877 | 15287 | 29854239 |
Coronavirus test positive | 10.06 | 9.84 | 8 | 82944 | 332 | 29869194 |
Skin graft failure | 10.04 | 9.84 | 6 | 82946 | 155 | 29869371 |
Peritonitis bacterial | 10.04 | 9.84 | 10 | 82942 | 11368 | 29858158 |
Glycosylated haemoglobin increased | 10.03 | 9.84 | 7 | 82945 | 9484 | 29860042 |
Dermatitis exfoliative | 9.94 | 9.84 | 44 | 82908 | 7412 | 29862114 |
Diarrhoea haemorrhagic | 9.92 | 9.84 | 37 | 82915 | 5768 | 29863758 |
Hypersomnia | 9.92 | 9.84 | 10 | 82942 | 11306 | 29858220 |
Small intestinal obstruction | 9.92 | 9.84 | 14 | 82938 | 13645 | 29855881 |
Venoocclusive liver disease | 9.89 | 9.84 | 3 | 82949 | 6610 | 29862916 |
Precancerous condition | 9.88 | 9.84 | 3 | 82949 | 12 | 29869514 |
Genital lesion | 9.86 | 9.84 | 7 | 82945 | 244 | 29869282 |
Dementia | 9.84 | 9.84 | 12 | 82940 | 12449 | 29857077 |
Source | Code | Description |
---|---|---|
ATC | J01CA04 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Penicillins with extended spectrum |
ATC | A02BD01 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD03 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD04 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD05 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD06 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD07 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD10 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD11 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD12 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD13 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD14 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | A02BD15 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Combinations for eradication of Helicobacter pylori |
ATC | J01CR02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Combinations of penicillins, incl. beta-lactamase inhibitors |
FDA CS | M0016152 | Penicillins |
FDA EPC | N0000175497 | Penicillin-class Antibacterial |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute otitis media | indication | 3110003 | |
Staphylococcal tonsillitis | indication | 11461005 | |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Streptococcal tonsillitis | indication | 41582007 | |
Lower respiratory tract infection | indication | 50417007 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Klebsiella cystitis | indication | 60867007 | |
Pneumonia due to Klebsiella pneumoniae | indication | 64479007 | |
Urinary tract infectious disease | indication | 68566005 | |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Infection due to Escherichia coli | indication | 71057007 | |
Rhinoscleroma | indication | 72409005 | DOID:11336 |
Acute bacterial sinusitis | indication | 75498004 | |
Staphylococcal pharyngitis | indication | 82228008 | |
Pneumococcal pneumonia | indication | 233607000 | |
Escherichia coli urinary tract infection | indication | 301011002 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Bacterial urinary infection | indication | 312124009 | |
Infective otitis media | indication | 312218008 | |
Pharyngitis | indication | 405737000 | DOID:2275 |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Acute exacerbation of chronic bronchitis | indication | 425748003 | |
Pneumonia due to Staphylococcus aureus | indication | 441658007 | |
Helicobacter pylori-associated gastritis | indication | 708164002 | |
Skin and Skin Structure Streptococcus Infection | indication | ||
E. Coli Genitourinary Tract Infection | indication | ||
Moraxella Catarrhalis Acute Otitis Media | indication | ||
Duodenal Ulcer due to H. Pylori | indication | ||
Haemophilus Influenzae Chronic Bronchitis | indication | ||
Moraxella Catarrhalis Pneumonia | indication | ||
Tonsillitis due to Haemophilus Influenzae | indication | ||
Genitourinary Tract Infections | indication | ||
Haemophilus Influenzae Pharyngitis | indication | ||
Genitourinary Tract Infection due to Proteus | indication | ||
Haemophilus Influenzae Acute Otitis Media | indication | ||
Pneumococcal Acute Otitis Media | indication | ||
Haemophilus Parainfluenzae Pneumonia | indication | ||
Streptococcus Pneumoniae Chronic Bronchitis | indication | ||
Enterococcus Genitourinary Tract Infection | indication | ||
Typhoid fever | off-label use | 4834000 | DOID:13258 |
Pyrexia of unknown origin | off-label use | 7520000 | |
Lyme disease | off-label use | 23502006 | DOID:11729 |
Chronic purulent otitis media | off-label use | 38394007 | DOID:14247 |
Cholangitis | off-label use | 82403002 | DOID:9446 |
Human bite - wound | off-label use | 262555007 | |
Chancroid | off-label use | 266143009 | DOID:13778 |
Diverticulitis of gastrointestinal tract | off-label use | 271366000 | |
Dog bite - wound | off-label use | 283734005 | |
Cat bite - wound | off-label use | 283782004 | |
Prevention of Bacterial Endocarditis | off-label use | ||
Diabetic Foot Infection | off-label use | ||
Prevention of Neonatal Group B Streptococcal Infection | off-label use | ||
Ventricular tachycardia | contraindication | 25569003 | |
Obstruction of bile duct | contraindication | 30144000 | |
Torsades de pointes | contraindication | 31722008 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Cholestatic hepatitis | contraindication | 95556007 | |
Prolonged QT interval | contraindication | 111975006 | |
Fracture of bone | contraindication | 125605004 | |
Liver function tests abnormal | contraindication | 166603001 | |
Hypomagnesemia | contraindication | 190855004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Infectious mononucleosis | contraindication | 271558008 | DOID:8568 |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Porphyria | contraindication | 418470004 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.79 | acidic |
pKa2 | 9.72 | acidic |
pKa3 | 7.63 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2B | GPCR | IC50 | 5.96 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2A | GPCR | IC50 | 6.22 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2C | GPCR | IC50 | 5.80 | WOMBAT-PK | |||||
Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Penicillin-binding protein 1A | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
9EM05410Q9 | UNII |
4017605 | VUID |
N0000145985 | NUI |
D00229 | KEGG_DRUG |
34642-77-8 | SECONDARY_CAS_RN |
C0002645 | UMLSCUI |
CHEBI:2676 | CHEBI |
AXL | PDB_CHEM_ID |
CHEMBL1082 | ChEMBL_ID |
CHEMBL2105950 | ChEMBL_ID |
DB01060 | DRUGBANK_ID |
D000658 | MESH_DESCRIPTOR_UI |
33613 | PUBCHEM_CID |
3230 | INN_ID |
10895 | IUPHAR_LIGAND_ID |
1297882 | RXNORM |
11786 | MMSL |
3600 | MMSL |
4187 | MMSL |
d00088 | MMSL |
002707 | NDDF |
003675 | NDDF |
003718 | NDDF |
27658006 | SNOMEDCT_US |
372687004 | SNOMEDCT_US |
427483001 | SNOMEDCT_US |
785686003 | SNOMEDCT_US |
96068000 | SNOMEDCT_US |
4017604 | VANDF |
4017605 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Amoxicillin and Clavulanate Potassium | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0781-1943 | TABLET, MULTILAYER, EXTENDED RELEASE | 437.50 mg | ORAL | ANDA | 26 sections |
Amoxicillin and Clavulanate Potassium Extended Release | HUMAN PRESCRIPTION DRUG LABEL | 3 | 43598-220 | TABLET, FILM COATED, EXTENDED RELEASE | 437.50 mg | ORAL | NDA | 27 sections |