All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

bamipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
tricyclic compounds	288	4945-47-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: piperamine bamipine dihydrochloride bamipine lactate bamipine monohydrochloride bamipine citrate bamipine dihydrochloride hydrate multifungin bamipine taumidrine bamipin	Molecular weight: 280.42 Formula: C19H24N2 CLOGP: 4.13 LIPINSKI: 0 HAC: 2 HDO: 0 TPSA: 6.48 ALOGS: -3.81 ROTB: 4

Drug dosage:

Dose	Unit	Route
0.10	g	O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TGFBR1,TTK	48
kinase-selectivity-class	AKT3,AXL,CAMK2D,EPHB4,ERBB2,PDK4,SIK2,STK33,TEK	9
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D04AA15	DERMATOLOGICALS ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. Antihistamines for topical use
ATC	R06AX01	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Other antihistamines for systemic use
MeSH PA	D006633	Histamine Antagonists
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018494	Histamine Agents

Related Drugs by ATC class:

D04AA Antihistamines for topical use 13 drugs

chloropyraminechlorphenoxamineclemastinedimetindenediphenhydramineisothipendylmepyraminepheniraminepromethazinethenalidinethonzylaminetolpropamine show all 13 →

R06AX Other antihistamines for systemic use 26 drugs

acrivastineantazolineastemizoleazatadineazelastinebilastinecyproheptadinedeptropinedesloratadineebastineepinastinefexofenadine show all 26 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Urticaria	indication	126485001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.35	Basic
pKa2	5.65	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST				KEGG DRUG	KEGG DRUG

External reference:

ID	Source
D07197	KEGG_DRUG
61732-85-2	SECONDARY_CAS_RN
61670-09-5	SECONDARY_CAS_RN
18753	RXNORM
C0052946	UMLSCUI
CHEBI:135165	CHEBI
CHEMBL520400	ChEMBL_ID
DB13489	DRUGBANK_ID
C020867	MESH_SUPPLEMENTAL_RECORD_UI
72075	PUBCHEM_CID
C029080	MESH_SUPPLEMENTAL_RECORD_UI
1285	INN_ID
Y6BHZ28O92	UNII
003726	NDDF
006226	NDDF

Pharmaceutical products:

None