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deptropine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| atropine derivatives | 808 | 604-51-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
minor descriptor (65-85); on-line & Index Medicus search TROPANES (66-85); RN given refers to parent cpd
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 2 | mg | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PDPK1,PIM2,PRKDC,TEK,TGFBR1 | 32 | |||
| kinase-selectivity-class | AXL,EIF2AK3,PDK4 | 3 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R06AX16 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Other antihistamines for systemic use |
| MeSH PA | D006633 | Histamine Antagonists |
| MeSH PA | D006634 | Histamine H1 Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018494 | Histamine Agents |
| CHEBI has role | CHEBI:37955 | H<small><sub>1</sub></small>-receptor antagonist |
| CHEBI has role | CHEBI:48876 | muscarinic antagonist |
| CHEBI has role | CHEBI:50370 | parasympatholytic |
Related Drugs by ATC class:
R06AX Other antihistamines for systemic use 26 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.86 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Acetylcholine-binding protein | Secreted | Ki | 5.70 | CHEMBL | |||||
| Soluble acetylcholine receptor | Secreted | Ki | 5.20 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D07404 | KEGG_DRUG |
| C0057763 | UMLSCUI |
| CHEBI:50189 | CHEBI |
| CHEMBL1946186 | ChEMBL_ID |
| DB13466 | DRUGBANK_ID |
| 203911 | PUBCHEM_CID |
| C100220 | MESH_SUPPLEMENTAL_RECORD_UI |
| 1331 | INN_ID |
| 2169-75-7 | SECONDARY_CAS_RN |
| AY31301GKG | UNII |
| CHEMBL2107603 | ChEMBL_ID |
| AY31301GKG | INXIGHT DRUGS |
Pharmaceutical products:
None