Stem definition | Drug id | CAS RN |
---|---|---|
2286 | 60-87-7 |
Dose | Unit | Route |
---|---|---|
25 | mg | O |
25 | mg | P |
25 | mg | R |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 2 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 5.03 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 25 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 14 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 14 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.09 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 14 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
March 29, 1951 | FDA | DELCOR ASSET CORP |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Intentional self-injury | 6677.07 | 10.13 | 2019 | 59356 | 21093 | 50522656 |
Intentional overdose | 5455.80 | 10.13 | 2239 | 59136 | 60265 | 50483484 |
Akathisia | 530.44 | 10.13 | 239 | 61136 | 7990 | 50535759 |
Tachycardia | 464.40 | 10.13 | 588 | 60787 | 99175 | 50444574 |
Depressed level of consciousness | 393.97 | 10.13 | 395 | 60980 | 51558 | 50492191 |
Cholecystitis chronic | 296.50 | 10.13 | 170 | 61205 | 9499 | 50534250 |
Drug ineffective | 278.75 | 10.13 | 353 | 61022 | 818980 | 49724769 |
Mydriasis | 273.88 | 10.13 | 167 | 61208 | 10460 | 50533289 |
Anxiety | 185.68 | 10.13 | 554 | 60821 | 177052 | 50366697 |
Contraindicated product administered | 161.67 | 10.13 | 4 | 61371 | 148954 | 50394795 |
Hallucination | 143.78 | 10.13 | 226 | 61149 | 46431 | 50497318 |
Synovitis | 121.93 | 10.13 | 7 | 61368 | 123858 | 50419891 |
Somnolence | 120.15 | 10.13 | 437 | 60938 | 154548 | 50389201 |
Drug intolerance | 115.31 | 10.13 | 61 | 61314 | 219043 | 50324706 |
Poisoning | 113.94 | 10.13 | 105 | 61270 | 12324 | 50531425 |
Treatment failure | 111.28 | 10.13 | 17 | 61358 | 137620 | 50406129 |
Glossodynia | 109.40 | 10.13 | 8 | 61367 | 115561 | 50428188 |
Agitation | 104.38 | 10.13 | 212 | 61163 | 53172 | 50490577 |
Hand deformity | 103.98 | 10.13 | 4 | 61371 | 100195 | 50443554 |
Joint swelling | 103.89 | 10.13 | 87 | 61288 | 245199 | 50298550 |
Rheumatoid arthritis | 99.96 | 10.13 | 61 | 61314 | 202489 | 50341260 |
Biliary dyskinesia | 97.87 | 10.13 | 52 | 61323 | 2498 | 50541251 |
Injury | 96.49 | 10.13 | 195 | 61180 | 48730 | 50495019 |
Off label use | 95.16 | 10.13 | 279 | 61096 | 474147 | 50069602 |
Emotional distress | 92.69 | 10.13 | 142 | 61233 | 28521 | 50515228 |
Gallbladder disorder | 91.20 | 10.13 | 107 | 61268 | 16635 | 50527114 |
Arthropathy | 89.06 | 10.13 | 40 | 61335 | 157866 | 50385883 |
Suicide attempt | 86.75 | 10.13 | 193 | 61182 | 51539 | 50492210 |
Sinus tachycardia | 85.40 | 10.13 | 117 | 61258 | 21237 | 50522512 |
Gallbladder injury | 84.68 | 10.13 | 38 | 61337 | 1256 | 50542493 |
Vomiting | 83.46 | 10.13 | 889 | 60486 | 459869 | 50083880 |
Therapeutic product effect decreased | 82.32 | 10.13 | 31 | 61344 | 136019 | 50407730 |
Systemic lupus erythematosus | 80.27 | 10.13 | 35 | 61340 | 140587 | 50403162 |
Migraine | 75.82 | 10.13 | 232 | 61143 | 75048 | 50468701 |
Pericarditis | 70.21 | 10.13 | 7 | 61368 | 78682 | 50465067 |
Abdominal discomfort | 69.94 | 10.13 | 108 | 61267 | 231533 | 50312216 |
Cholelithiasis | 68.59 | 10.13 | 146 | 61229 | 37827 | 50505922 |
Infusion related reaction | 63.66 | 10.13 | 67 | 61308 | 169490 | 50374259 |
Rash | 62.87 | 10.13 | 295 | 61080 | 437176 | 50106573 |
Nasopharyngitis | 62.09 | 10.13 | 86 | 61289 | 192841 | 50350908 |
Alopecia | 60.77 | 10.13 | 129 | 61246 | 244918 | 50298831 |
Snoring | 59.79 | 10.13 | 42 | 61333 | 3342 | 50540407 |
Drug abuse | 58.91 | 10.13 | 183 | 61192 | 59663 | 50484086 |
Toxicity to various agents | 58.84 | 10.13 | 450 | 60925 | 212049 | 50331700 |
Product use issue | 58.46 | 10.13 | 57 | 61318 | 149418 | 50394331 |
Incoherent | 57.86 | 10.13 | 45 | 61330 | 4185 | 50539564 |
Wound | 57.77 | 10.13 | 28 | 61347 | 105766 | 50437983 |
Hepatic enzyme increased | 57.76 | 10.13 | 49 | 61326 | 137331 | 50406418 |
Respiratory arrest | 57.25 | 10.13 | 118 | 61257 | 29891 | 50513858 |
Muscle twitching | 54.96 | 10.13 | 80 | 61295 | 15351 | 50528398 |
Accidental overdose | 51.21 | 10.13 | 88 | 61287 | 19445 | 50524304 |
Arthralgia | 50.25 | 10.13 | 319 | 61056 | 438383 | 50105366 |
Loss of consciousness | 48.94 | 10.13 | 253 | 61122 | 104100 | 50439649 |
Formication | 48.17 | 10.13 | 38 | 61337 | 3608 | 50540141 |
Dependence | 47.11 | 10.13 | 29 | 61346 | 1846 | 50541903 |
Therapeutic product effect incomplete | 45.88 | 10.13 | 27 | 61348 | 91488 | 50452261 |
Lethargy | 45.76 | 10.13 | 148 | 61227 | 49284 | 50494465 |
Peripheral swelling | 45.72 | 10.13 | 115 | 61260 | 205821 | 50337928 |
Deep vein thrombosis | 45.59 | 10.13 | 193 | 61182 | 73111 | 50470638 |
Pulmonary haemorrhage neonatal | 45.56 | 10.13 | 10 | 61365 | 22 | 50543727 |
Abdominal pain | 44.07 | 10.13 | 459 | 60916 | 235769 | 50307980 |
Opisthotonus | 43.46 | 10.13 | 16 | 61359 | 313 | 50543436 |
Helicobacter infection | 42.86 | 10.13 | 5 | 61370 | 49697 | 50494052 |
Drug hypersensitivity | 42.79 | 10.13 | 479 | 60896 | 250531 | 50293218 |
Hereditary angioedema | 40.50 | 10.13 | 41 | 61334 | 5401 | 50538348 |
Accidental death | 38.86 | 10.13 | 25 | 61350 | 1719 | 50542030 |
C-reactive protein increased | 38.78 | 10.13 | 16 | 61359 | 66458 | 50477291 |
Swelling | 38.77 | 10.13 | 120 | 61255 | 200752 | 50342997 |
Lower respiratory tract infection | 38.74 | 10.13 | 35 | 61340 | 95166 | 50448583 |
Pupillary reflex impaired | 37.14 | 10.13 | 25 | 61350 | 1856 | 50541893 |
Hypersensitivity | 37.11 | 10.13 | 135 | 61240 | 215026 | 50328723 |
Drug abuser | 36.34 | 10.13 | 29 | 61346 | 2799 | 50540950 |
Serotonin syndrome | 34.65 | 10.13 | 86 | 61289 | 24627 | 50519122 |
Impaired healing | 34.40 | 10.13 | 21 | 61354 | 69765 | 50473984 |
Congenital tricuspid valve incompetence | 34.05 | 10.13 | 10 | 61365 | 92 | 50543657 |
Mental status changes | 33.02 | 10.13 | 108 | 61267 | 36164 | 50507585 |
Nausea | 32.51 | 10.13 | 1100 | 60275 | 704298 | 49839451 |
Electrocardiogram QRS complex shortened | 32.46 | 10.13 | 14 | 61361 | 420 | 50543329 |
Neonatal hypotension | 32.28 | 10.13 | 10 | 61365 | 112 | 50543637 |
Cardiac failure | 32.09 | 10.13 | 27 | 61348 | 76013 | 50467736 |
Dysarthria | 31.95 | 10.13 | 109 | 61266 | 37294 | 50506455 |
Discomfort | 31.28 | 10.13 | 52 | 61323 | 108328 | 50435421 |
Infection | 30.82 | 10.13 | 107 | 61268 | 172847 | 50370902 |
Newborn persistent pulmonary hypertension | 30.25 | 10.13 | 10 | 61365 | 140 | 50543609 |
Cardiac arrest | 29.48 | 10.13 | 188 | 61187 | 83463 | 50460286 |
Suicidal ideation | 29.30 | 10.13 | 139 | 61236 | 55246 | 50488503 |
Folliculitis | 29.16 | 10.13 | 6 | 61369 | 39219 | 50504530 |
Maternal exposure during pregnancy | 29.04 | 10.13 | 98 | 61277 | 159680 | 50384069 |
Cholecystitis | 28.18 | 10.13 | 56 | 61319 | 13815 | 50529934 |
Drug screen positive | 27.85 | 10.13 | 27 | 61348 | 3375 | 50540374 |
Neonatal respiratory failure | 27.63 | 10.13 | 10 | 61365 | 186 | 50543563 |
Gallbladder hypofunction | 26.85 | 10.13 | 13 | 61362 | 512 | 50543237 |
Depression | 26.05 | 10.13 | 311 | 61064 | 165112 | 50378637 |
Gallbladder cholesterolosis | 25.50 | 10.13 | 14 | 61361 | 718 | 50543031 |
Pulmonary embolism | 25.15 | 10.13 | 210 | 61165 | 101494 | 50442255 |
General physical health deterioration | 24.78 | 10.13 | 89 | 61286 | 142345 | 50401404 |
Mobility decreased | 24.35 | 10.13 | 37 | 61338 | 79911 | 50463838 |
Drug reaction with eosinophilia and systemic symptoms | 24.16 | 10.13 | 3 | 61372 | 28421 | 50515328 |
Biliary colic | 23.24 | 10.13 | 24 | 61351 | 3235 | 50540514 |
Completed suicide | 22.57 | 10.13 | 252 | 61123 | 131637 | 50412112 |
Exposure via ingestion | 22.49 | 10.13 | 22 | 61353 | 2781 | 50540968 |
Renal impairment | 22.10 | 10.13 | 36 | 61339 | 75625 | 50468124 |
Dehydration | 22.01 | 10.13 | 282 | 61093 | 152167 | 50391582 |
Product use in unapproved indication | 21.76 | 10.13 | 70 | 61305 | 115749 | 50428000 |
Fatigue | 21.55 | 10.13 | 1056 | 60319 | 706545 | 49837204 |
Miosis | 21.44 | 10.13 | 32 | 61343 | 6278 | 50537471 |
Atrial septal defect | 21.32 | 10.13 | 32 | 61343 | 6309 | 50537440 |
Anhedonia | 21.24 | 10.13 | 40 | 61335 | 9484 | 50534265 |
Musculoskeletal stiffness | 20.59 | 10.13 | 83 | 61292 | 128398 | 50415351 |
Hip arthroplasty | 20.01 | 10.13 | 6 | 61369 | 30423 | 50513326 |
Impaired gastric emptying | 19.92 | 10.13 | 37 | 61338 | 8681 | 50535068 |
Cholesterosis | 19.86 | 10.13 | 10 | 61365 | 429 | 50543320 |
Cough | 19.80 | 10.13 | 192 | 61183 | 241072 | 50302677 |
Fear | 19.73 | 10.13 | 50 | 61325 | 14499 | 50529250 |
Illness anxiety disorder | 19.66 | 10.13 | 7 | 61368 | 124 | 50543625 |
Electrocardiogram QT prolonged | 19.14 | 10.13 | 118 | 61257 | 51768 | 50491981 |
Coma blister | 18.51 | 10.13 | 7 | 61368 | 148 | 50543601 |
Gastrointestinal disorder | 18.51 | 10.13 | 56 | 61319 | 94400 | 50449349 |
Therapeutic response decreased | 18.46 | 10.13 | 18 | 61357 | 47213 | 50496536 |
Differential white blood cell count abnormal | 18.04 | 10.13 | 11 | 61364 | 688 | 50543061 |
Drug withdrawal syndrome | 17.95 | 10.13 | 69 | 61306 | 25012 | 50518737 |
Stomatitis | 17.84 | 10.13 | 63 | 61312 | 101281 | 50442468 |
Restlessness | 17.80 | 10.13 | 69 | 61306 | 25104 | 50518645 |
Paranoia | 17.78 | 10.13 | 39 | 61336 | 10309 | 50533440 |
Hyperreflexia | 17.45 | 10.13 | 26 | 61349 | 5092 | 50538657 |
Ill-defined disorder | 16.92 | 10.13 | 25 | 61350 | 54629 | 50489120 |
Cholestasis | 16.72 | 10.13 | 5 | 61370 | 25396 | 50518353 |
Blastocystis infection | 16.25 | 10.13 | 4 | 61371 | 17 | 50543732 |
Pupil fixed | 15.98 | 10.13 | 14 | 61361 | 1538 | 50542211 |
Ventricular septal defect | 15.94 | 10.13 | 22 | 61353 | 4019 | 50539730 |
Cardio-respiratory arrest | 15.93 | 10.13 | 116 | 61259 | 53776 | 50489973 |
Cholecystectomy | 15.91 | 10.13 | 35 | 61340 | 9268 | 50534481 |
Jaw clicking | 15.89 | 10.13 | 4 | 61371 | 19 | 50543730 |
Blister | 15.78 | 10.13 | 52 | 61323 | 85366 | 50458383 |
Seizure | 15.74 | 10.13 | 215 | 61160 | 117659 | 50426090 |
Red blood cell sedimentation rate increased | 15.72 | 10.13 | 8 | 61367 | 29408 | 50514341 |
Neutropenia | 15.66 | 10.13 | 110 | 61265 | 147855 | 50395894 |
Vasoplegia syndrome | 15.56 | 10.13 | 12 | 61363 | 1102 | 50542647 |
Condition aggravated | 15.55 | 10.13 | 260 | 61115 | 296798 | 50246951 |
Fear of disease | 15.48 | 10.13 | 11 | 61364 | 891 | 50542858 |
Mental disorder | 15.33 | 10.13 | 60 | 61315 | 21931 | 50521818 |
Arthritis | 15.20 | 10.13 | 54 | 61321 | 86667 | 50457082 |
Device expulsion | 15.17 | 10.13 | 8 | 61367 | 28814 | 50514935 |
Tremor | 15.10 | 10.13 | 209 | 61166 | 114694 | 50429055 |
Aggression | 15.03 | 10.13 | 58 | 61317 | 21058 | 50522691 |
Melaena | 14.82 | 10.13 | 7 | 61368 | 26857 | 50516892 |
Attention-seeking behaviour | 14.81 | 10.13 | 5 | 61370 | 75 | 50543674 |
Blood pressure fluctuation | 14.77 | 10.13 | 13 | 61362 | 35810 | 50507939 |
pH body fluid increased | 14.61 | 10.13 | 3 | 61372 | 4 | 50543745 |
Unresponsive to stimuli | 14.18 | 10.13 | 74 | 61301 | 30535 | 50513214 |
Loss of personal independence in daily activities | 14.10 | 10.13 | 41 | 61334 | 70009 | 50473740 |
Respiratory rate decreased | 13.91 | 10.13 | 18 | 61357 | 3090 | 50540659 |
Base excess increased | 13.70 | 10.13 | 4 | 61371 | 36 | 50543713 |
Pancreatitis chronic | 13.46 | 10.13 | 15 | 61360 | 2205 | 50541544 |
Respiratory rate increased | 13.28 | 10.13 | 37 | 61338 | 11348 | 50532401 |
Acute lung injury | 13.22 | 10.13 | 12 | 61363 | 1381 | 50542368 |
Fall | 13.04 | 10.13 | 308 | 61067 | 334624 | 50209125 |
Finger amputation | 12.84 | 10.13 | 8 | 61367 | 520 | 50543229 |
Cytomegalovirus infection | 12.84 | 10.13 | 3 | 61372 | 17959 | 50525790 |
Jugular vein thrombosis | 12.68 | 10.13 | 16 | 61359 | 2680 | 50541069 |
Postpartum haemorrhage | 12.66 | 10.13 | 13 | 61362 | 1741 | 50542008 |
Pulmonary fibrosis | 12.54 | 10.13 | 7 | 61368 | 24430 | 50519319 |
Hepatocellular injury | 12.52 | 10.13 | 8 | 61367 | 25939 | 50517810 |
Osteoporosis | 12.51 | 10.13 | 22 | 61353 | 44857 | 50498892 |
Psychotic disorder | 12.46 | 10.13 | 56 | 61319 | 21756 | 50521993 |
Patent ductus arteriosus | 12.45 | 10.13 | 19 | 61356 | 3801 | 50539948 |
Prolonged rupture of membranes | 12.37 | 10.13 | 4 | 61371 | 52 | 50543697 |
Neonatal tachycardia | 12.33 | 10.13 | 3 | 61372 | 12 | 50543737 |
Dyspnoea | 12.32 | 10.13 | 541 | 60834 | 547067 | 49996682 |
Overdose | 12.15 | 10.13 | 179 | 61196 | 99548 | 50444201 |
Acute kidney injury | 12.12 | 10.13 | 199 | 61176 | 227859 | 50315890 |
Drug interaction | 12.04 | 10.13 | 170 | 61205 | 199451 | 50344298 |
Drug resistance | 12.03 | 10.13 | 4 | 61371 | 18985 | 50524764 |
Lentigo | 12.01 | 10.13 | 6 | 61369 | 253 | 50543496 |
Uterine perforation | 11.97 | 10.13 | 25 | 61350 | 6390 | 50537359 |
Herpes zoster | 11.80 | 10.13 | 45 | 61330 | 70741 | 50473008 |
Intestinal obstruction | 11.69 | 10.13 | 63 | 61312 | 26320 | 50517429 |
Hyperkinetic heart syndrome | 11.63 | 10.13 | 3 | 61372 | 16 | 50543733 |
Knee arthroplasty | 11.49 | 10.13 | 16 | 61359 | 35830 | 50507919 |
Hypophagia | 11.47 | 10.13 | 65 | 61310 | 27663 | 50516086 |
Pickwickian syndrome | 11.45 | 10.13 | 6 | 61369 | 280 | 50543469 |
Psoriatic arthropathy | 11.43 | 10.13 | 25 | 61350 | 47007 | 50496742 |
Hypopnoea | 11.41 | 10.13 | 14 | 61361 | 2279 | 50541470 |
Slow response to stimuli | 11.36 | 10.13 | 9 | 61366 | 860 | 50542889 |
Cholecystitis acute | 11.33 | 10.13 | 26 | 61349 | 7080 | 50536669 |
Patient uncooperative | 11.32 | 10.13 | 5 | 61370 | 159 | 50543590 |
Arm amputation | 11.19 | 10.13 | 3 | 61372 | 19 | 50543730 |
Ventricular extrasystoles | 11.13 | 10.13 | 33 | 61342 | 10483 | 50533266 |
Nephrolithiasis | 11.02 | 10.13 | 76 | 61299 | 34617 | 50509132 |
Therapy non-responder | 10.91 | 10.13 | 29 | 61346 | 50993 | 50492756 |
Drug dependence | 10.74 | 10.13 | 50 | 61325 | 19709 | 50524040 |
Fallot's tetralogy | 10.74 | 10.13 | 4 | 61371 | 81 | 50543668 |
Respiratory disorder neonatal | 10.73 | 10.13 | 9 | 61366 | 932 | 50542817 |
Blood potassium decreased | 10.62 | 10.13 | 79 | 61296 | 36866 | 50506883 |
Scar | 10.58 | 10.13 | 35 | 61340 | 11783 | 50531966 |
Visceral oedema | 10.48 | 10.13 | 3 | 61372 | 25 | 50543724 |
Transverse sinus thrombosis | 10.43 | 10.13 | 7 | 61368 | 517 | 50543232 |
Arteriovenous fistula thrombosis | 10.37 | 10.13 | 5 | 61370 | 195 | 50543554 |
Radial pulse abnormal | 10.27 | 10.13 | 3 | 61372 | 27 | 50543722 |
Pre-existing condition improved | 10.27 | 10.13 | 25 | 61350 | 7072 | 50536677 |
Inflammation | 10.27 | 10.13 | 35 | 61340 | 56877 | 50486872 |
Psychological trauma | 10.25 | 10.13 | 9 | 61366 | 991 | 50542758 |
Basal cell carcinoma | 10.22 | 10.13 | 8 | 61367 | 23348 | 50520401 |
Constipation | 10.15 | 10.13 | 296 | 61079 | 185412 | 50358337 |
Gas gangrene | 10.14 | 10.13 | 4 | 61371 | 95 | 50543654 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Intentional self-injury | 2134.88 | 11.91 | 661 | 22840 | 11800 | 29539226 |
Intentional overdose | 1684.22 | 11.91 | 748 | 22753 | 37780 | 29513246 |
Akathisia | 152.69 | 11.91 | 84 | 23417 | 6658 | 29544368 |
Depressed level of consciousness | 121.08 | 11.91 | 148 | 23353 | 36794 | 29514232 |
Tachycardia | 93.68 | 11.91 | 189 | 23312 | 72221 | 29478805 |
Respiratory arrest | 87.06 | 11.91 | 105 | 23396 | 25728 | 29525298 |
Sinus tachycardia | 65.65 | 11.91 | 70 | 23431 | 14999 | 29536027 |
Mydriasis | 60.25 | 11.91 | 45 | 23456 | 6040 | 29544986 |
Drug ineffective | 57.08 | 11.91 | 128 | 23373 | 363042 | 29187984 |
Somnolence | 55.08 | 11.91 | 182 | 23319 | 93773 | 29457253 |
Poisoning | 53.70 | 11.91 | 52 | 23449 | 9941 | 29541085 |
Off label use | 52.30 | 11.91 | 100 | 23401 | 300700 | 29250326 |
Vomiting | 48.39 | 11.91 | 311 | 23190 | 211949 | 29339077 |
Agitation | 46.19 | 11.91 | 116 | 23385 | 51188 | 29499838 |
Hallucination | 40.14 | 11.91 | 101 | 23400 | 44611 | 29506415 |
Dysarthria | 39.09 | 11.91 | 80 | 23421 | 30831 | 29520195 |
Loss of consciousness | 38.60 | 11.91 | 138 | 23363 | 73918 | 29477108 |
Exposure during pregnancy | 35.95 | 11.91 | 39 | 23462 | 8515 | 29542511 |
Consciousness fluctuating | 32.96 | 11.91 | 16 | 23485 | 976 | 29550050 |
Neuroleptic malignant syndrome | 32.24 | 11.91 | 51 | 23450 | 16097 | 29534929 |
Dystonia | 31.80 | 11.91 | 39 | 23462 | 9710 | 29541316 |
Anxiety | 30.12 | 11.91 | 141 | 23360 | 85224 | 29465802 |
Interstitial lung disease | 29.82 | 11.91 | 5 | 23496 | 57713 | 29493313 |
Cardio-respiratory arrest | 28.70 | 11.91 | 97 | 23404 | 50504 | 29500522 |
Dehydration | 27.84 | 11.91 | 171 | 23330 | 114577 | 29436449 |
Lethargy | 26.80 | 11.91 | 78 | 23423 | 37502 | 29513524 |
Failure to thrive | 25.49 | 11.91 | 31 | 23470 | 7653 | 29543373 |
Cardiac arrest | 24.30 | 11.91 | 133 | 23368 | 85458 | 29465568 |
General symptom | 23.50 | 11.91 | 12 | 23489 | 816 | 29550210 |
Dextrocardia | 23.11 | 11.91 | 7 | 23494 | 114 | 29550912 |
Confusional state | 22.96 | 11.91 | 177 | 23324 | 127700 | 29423326 |
Foetal alcohol syndrome | 21.86 | 11.91 | 7 | 23494 | 138 | 29550888 |
Drug withdrawal syndrome | 20.93 | 11.91 | 45 | 23456 | 17939 | 29533087 |
Nausea | 20.53 | 11.91 | 333 | 23168 | 288922 | 29262104 |
Nasopharyngitis | 20.37 | 11.91 | 11 | 23490 | 59654 | 29491372 |
Opisthotonus | 20.31 | 11.91 | 9 | 23492 | 445 | 29550581 |
Atrial septal defect | 20.29 | 11.91 | 26 | 23475 | 6763 | 29544263 |
Drug hypersensitivity | 19.88 | 11.91 | 107 | 23394 | 68299 | 29482727 |
Hepatic ischaemia | 18.38 | 11.91 | 8 | 23493 | 379 | 29550647 |
Patent ductus arteriosus | 18.16 | 11.91 | 17 | 23484 | 3114 | 29547912 |
General physical health deterioration | 17.96 | 11.91 | 34 | 23467 | 102823 | 29448203 |
Exposure via ingestion | 17.94 | 11.91 | 14 | 23487 | 2004 | 29549022 |
Obsessive thoughts | 17.61 | 11.91 | 9 | 23492 | 613 | 29550413 |
Toxicity to various agents | 17.14 | 11.91 | 212 | 23289 | 173449 | 29377577 |
Completed suicide | 16.79 | 11.91 | 126 | 23375 | 90120 | 29460906 |
Cardiomegaly | 16.64 | 11.91 | 35 | 23466 | 13741 | 29537285 |
Condition aggravated | 16.63 | 11.91 | 60 | 23441 | 146235 | 29404791 |
Sedation | 16.33 | 11.91 | 40 | 23461 | 17365 | 29533661 |
Fallot's tetralogy | 16.22 | 11.91 | 6 | 23495 | 185 | 29550841 |
Acute kidney injury | 16.21 | 11.91 | 134 | 23367 | 265133 | 29285893 |
Accidental overdose | 16.04 | 11.91 | 40 | 23461 | 17553 | 29533473 |
Skin swelling | 15.78 | 11.91 | 10 | 23491 | 1028 | 29549998 |
Therapeutic product effect incomplete | 15.35 | 11.91 | 6 | 23495 | 39299 | 29511727 |
Product use in unapproved indication | 14.92 | 11.91 | 29 | 23472 | 86846 | 29464180 |
Upper respiratory tract irritation | 14.91 | 11.91 | 4 | 23497 | 41 | 29550985 |
Overdose | 14.60 | 11.91 | 111 | 23390 | 79708 | 29471318 |
Psychotic disorder | 14.27 | 11.91 | 42 | 23459 | 20312 | 29530714 |
Gallbladder enlargement | 14.05 | 11.91 | 9 | 23492 | 942 | 29550084 |
Restlessness | 13.94 | 11.91 | 44 | 23457 | 22101 | 29528925 |
Psychomotor hyperactivity | 13.79 | 11.91 | 24 | 23477 | 8189 | 29542837 |
Fatigue | 13.79 | 11.91 | 339 | 23162 | 316482 | 29234544 |
Pupil fixed | 13.44 | 11.91 | 11 | 23490 | 1685 | 29549341 |
Renal impairment | 13.24 | 11.91 | 28 | 23473 | 81305 | 29469721 |
Acute chest syndrome | 13.20 | 11.91 | 6 | 23495 | 315 | 29550711 |
Ventricular septal defect | 12.96 | 11.91 | 15 | 23486 | 3514 | 29547512 |
Loss of control of legs | 12.95 | 11.91 | 7 | 23494 | 535 | 29550491 |
Labelled drug-drug interaction medication error | 12.54 | 11.91 | 29 | 23472 | 12130 | 29538896 |
Unresponsive to stimuli | 12.37 | 11.91 | 46 | 23455 | 25080 | 29525946 |
Mucosal haemorrhage | 12.34 | 11.91 | 10 | 23491 | 1511 | 29549515 |
Cardiac failure | 12.32 | 11.91 | 28 | 23473 | 79259 | 29471767 |
Snoring | 12.24 | 11.91 | 13 | 23488 | 2771 | 29548255 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Intentional self-injury | 5462.39 | 10.38 | 1740 | 61693 | 27304 | 64407995 |
Intentional overdose | 4253.85 | 10.38 | 1968 | 61465 | 87976 | 64347323 |
Akathisia | 557.28 | 10.38 | 257 | 63176 | 11253 | 64424046 |
Tachycardia | 383.74 | 10.38 | 594 | 62839 | 148985 | 64286314 |
Depressed level of consciousness | 352.01 | 10.38 | 417 | 63016 | 81019 | 64354280 |
Cholecystitis chronic | 276.30 | 10.38 | 149 | 63284 | 9138 | 64426161 |
Mydriasis | 228.62 | 10.38 | 158 | 63275 | 15154 | 64420145 |
Drug ineffective | 190.81 | 10.38 | 335 | 63098 | 839912 | 63595387 |
Anxiety | 177.84 | 10.38 | 519 | 62914 | 202130 | 64233169 |
Poisoning | 174.70 | 10.38 | 156 | 63277 | 21723 | 64413576 |
Respiratory arrest | 156.47 | 10.38 | 225 | 63208 | 52760 | 64382539 |
Hallucination | 140.80 | 10.38 | 255 | 63178 | 72533 | 64362766 |
Off label use | 138.23 | 10.38 | 258 | 63175 | 632548 | 63802751 |
Vomiting | 113.14 | 10.38 | 926 | 62507 | 550191 | 63885108 |
Somnolence | 111.83 | 10.38 | 446 | 62987 | 203199 | 64232100 |
Biliary dyskinesia | 105.60 | 10.38 | 50 | 63383 | 2322 | 64432977 |
Sinus tachycardia | 101.38 | 10.38 | 141 | 63292 | 32047 | 64403252 |
Agitation | 100.22 | 10.38 | 249 | 63184 | 88118 | 64347181 |
Injury | 95.60 | 10.38 | 186 | 63247 | 55806 | 64379493 |
Gallbladder injury | 93.25 | 10.38 | 37 | 63396 | 1111 | 64434188 |
Gallbladder disorder | 91.93 | 10.38 | 98 | 63335 | 16932 | 64418367 |
Emotional distress | 90.62 | 10.38 | 142 | 63291 | 35896 | 64399403 |
Synovitis | 84.08 | 10.38 | 3 | 63430 | 99087 | 64336212 |
Suicide attempt | 82.53 | 10.38 | 202 | 63231 | 70805 | 64364494 |
Toxicity to various agents | 76.65 | 10.38 | 615 | 62818 | 362898 | 64072401 |
Drug hypersensitivity | 71.64 | 10.38 | 439 | 62994 | 237376 | 64197923 |
Drug abuse | 68.68 | 10.38 | 285 | 63148 | 132089 | 64303210 |
Drug intolerance | 62.13 | 10.38 | 56 | 63377 | 187936 | 64247363 |
Cardiac arrest | 61.50 | 10.38 | 307 | 63126 | 153757 | 64281542 |
Nasopharyngitis | 59.49 | 10.38 | 63 | 63370 | 196010 | 64239289 |
Opisthotonus | 59.34 | 10.38 | 23 | 63410 | 648 | 64434651 |
Rheumatoid arthritis | 59.16 | 10.38 | 45 | 63388 | 164249 | 64271050 |
Contraindicated product administered | 54.44 | 10.38 | 19 | 63414 | 107810 | 64327489 |
Joint swelling | 54.06 | 10.38 | 80 | 63353 | 215302 | 64219997 |
Lethargy | 53.38 | 10.38 | 175 | 63258 | 72419 | 64362880 |
Accidental overdose | 51.90 | 10.38 | 107 | 63326 | 33450 | 64401849 |
Treatment failure | 51.82 | 10.38 | 25 | 63408 | 116791 | 64318508 |
Cholelithiasis | 51.32 | 10.38 | 128 | 63305 | 45378 | 64389921 |
Nausea | 49.71 | 10.38 | 1064 | 62369 | 784736 | 63650563 |
Hand deformity | 49.69 | 10.38 | 3 | 63430 | 62768 | 64372531 |
Loss of consciousness | 49.21 | 10.38 | 281 | 63152 | 148084 | 64287215 |
Migraine | 48.71 | 10.38 | 154 | 63279 | 62523 | 64372776 |
Completed suicide | 48.47 | 10.38 | 382 | 63051 | 224032 | 64211267 |
Drug abuser | 47.52 | 10.38 | 42 | 63391 | 5766 | 64429533 |
Serotonin syndrome | 46.96 | 10.38 | 113 | 63320 | 39169 | 64396130 |
Dysarthria | 44.38 | 10.38 | 144 | 63289 | 59262 | 64376037 |
Dependence | 43.83 | 10.38 | 27 | 63406 | 2128 | 64433171 |
Formication | 42.80 | 10.38 | 35 | 63398 | 4322 | 64430977 |
Muscle twitching | 42.49 | 10.38 | 71 | 63362 | 18927 | 64416372 |
Incoherent | 42.07 | 10.38 | 43 | 63390 | 7075 | 64428224 |
Cardiac failure | 41.88 | 10.38 | 41 | 63392 | 132332 | 64302967 |
Exposure via ingestion | 41.21 | 10.38 | 36 | 63397 | 4866 | 64430433 |
Cardio-respiratory arrest | 40.61 | 10.38 | 198 | 63235 | 98195 | 64337104 |
Snoring | 40.60 | 10.38 | 35 | 63398 | 4647 | 64430652 |
Arthropathy | 39.99 | 10.38 | 36 | 63397 | 120931 | 64314368 |
Therapeutic product effect decreased | 39.75 | 10.38 | 33 | 63400 | 115318 | 64319981 |
Pericarditis | 39.30 | 10.38 | 7 | 63426 | 62509 | 64372790 |
Deep vein thrombosis | 38.74 | 10.38 | 205 | 63228 | 104977 | 64330322 |
Drug withdrawal syndrome | 38.46 | 10.38 | 91 | 63342 | 31200 | 64404099 |
Abdominal pain | 37.69 | 10.38 | 471 | 62962 | 311904 | 64123395 |
Mental status changes | 37.63 | 10.38 | 139 | 63294 | 61023 | 64374276 |
Pupillary reflex impaired | 37.36 | 10.38 | 28 | 63405 | 3045 | 64432254 |
Arthralgia | 36.43 | 10.38 | 270 | 63163 | 441990 | 63993309 |
C-reactive protein increased | 35.44 | 10.38 | 25 | 63408 | 94884 | 64340415 |
Dehydration | 35.38 | 10.38 | 347 | 63086 | 216416 | 64218883 |
Acute kidney injury | 35.24 | 10.38 | 278 | 63155 | 448962 | 63986337 |
Therapeutic product effect incomplete | 35.17 | 10.38 | 30 | 63403 | 103452 | 64331847 |
Peripheral swelling | 35.13 | 10.38 | 98 | 63335 | 209055 | 64226244 |
Product use in unapproved indication | 34.13 | 10.38 | 77 | 63356 | 176541 | 64258758 |
Neuroleptic malignant syndrome | 33.26 | 10.38 | 75 | 63358 | 24921 | 64410378 |
Hereditary angioedema | 31.65 | 10.38 | 28 | 63405 | 3848 | 64431451 |
Glossodynia | 31.63 | 10.38 | 12 | 63421 | 64684 | 64370615 |
Renal impairment | 31.16 | 10.38 | 53 | 63380 | 134964 | 64300335 |
General physical health deterioration | 30.60 | 10.38 | 101 | 63332 | 204324 | 64230975 |
Interstitial lung disease | 30.07 | 10.38 | 31 | 63402 | 97701 | 64337598 |
Hepatic enzyme increased | 29.99 | 10.38 | 51 | 63382 | 129892 | 64305407 |
Fatigue | 29.77 | 10.38 | 954 | 62479 | 747776 | 63687523 |
Dystonia | 28.99 | 10.38 | 60 | 63373 | 18805 | 64416494 |
Restlessness | 28.42 | 10.38 | 95 | 63338 | 39690 | 64395609 |
Pain | 28.25 | 10.38 | 728 | 62705 | 552783 | 63882516 |
Drug screen positive | 27.50 | 10.38 | 31 | 63402 | 5698 | 64429601 |
Electrocardiogram QRS complex shortened | 26.97 | 10.38 | 13 | 63420 | 628 | 64434671 |
Impaired healing | 26.72 | 10.38 | 13 | 63420 | 60460 | 64374839 |
Accidental death | 26.68 | 10.38 | 25 | 63408 | 3700 | 64431599 |
Systemic lupus erythematosus | 25.76 | 10.38 | 23 | 63410 | 77589 | 64357710 |
Overdose | 25.32 | 10.38 | 254 | 63179 | 159312 | 64275987 |
Rash | 24.93 | 10.38 | 310 | 63123 | 458239 | 63977060 |
Abdominal discomfort | 24.66 | 10.38 | 94 | 63339 | 182228 | 64253071 |
Depression | 24.54 | 10.38 | 282 | 63151 | 183009 | 64252290 |
Gallbladder hypofunction | 24.51 | 10.38 | 11 | 63422 | 451 | 64434848 |
Cholestasis | 24.25 | 10.38 | 7 | 63426 | 44865 | 64390434 |
Drug resistance | 24.20 | 10.38 | 3 | 63430 | 35099 | 64400200 |
Pupil fixed | 23.74 | 10.38 | 22 | 63411 | 3210 | 64432089 |
Illness anxiety disorder | 23.72 | 10.38 | 9 | 63424 | 239 | 64435060 |
Infection | 23.31 | 10.38 | 98 | 63335 | 184782 | 64250517 |
Condition aggravated | 23.28 | 10.38 | 244 | 63189 | 372182 | 64063117 |
Drug interaction | 23.13 | 10.38 | 236 | 63197 | 361847 | 64073452 |
Lower respiratory tract infection | 22.89 | 10.38 | 36 | 63397 | 94578 | 64340721 |
Psychotic disorder | 22.46 | 10.38 | 80 | 63353 | 34498 | 64400801 |
Product use issue | 21.98 | 10.38 | 76 | 63357 | 151639 | 64283660 |
Osteonecrosis of jaw | 21.92 | 10.38 | 6 | 63427 | 39819 | 64395480 |
Pulmonary embolism | 21.80 | 10.38 | 230 | 63203 | 146126 | 64289173 |
Infusion related reaction | 21.47 | 10.38 | 86 | 63347 | 164381 | 64270918 |
Hypersensitivity | 21.30 | 10.38 | 110 | 63323 | 196342 | 64238957 |
Hepatocellular injury | 21.12 | 10.38 | 9 | 63424 | 45226 | 64390073 |
Alopecia | 20.78 | 10.38 | 88 | 63345 | 165602 | 64269697 |
Cholecystectomy | 20.67 | 10.38 | 32 | 63401 | 8000 | 64427299 |
Paranoia | 20.58 | 10.38 | 48 | 63385 | 16304 | 64418995 |
Wound | 20.57 | 10.38 | 27 | 63406 | 76450 | 64358849 |
Mobility decreased | 20.45 | 10.38 | 33 | 63400 | 85807 | 64349492 |
Cholesterosis | 20.36 | 10.38 | 9 | 63424 | 356 | 64434943 |
Miosis | 20.16 | 10.38 | 42 | 63391 | 13224 | 64422075 |
Fall | 20.03 | 10.38 | 289 | 63144 | 416537 | 64018762 |
Unresponsive to stimuli | 19.78 | 10.38 | 100 | 63333 | 50293 | 64385006 |
Cytomegalovirus infection | 19.75 | 10.38 | 6 | 63427 | 37193 | 64398106 |
Suicidal ideation | 19.46 | 10.38 | 122 | 63311 | 66420 | 64368879 |
Drug reaction with eosinophilia and systemic symptoms | 19.31 | 10.38 | 15 | 63418 | 54202 | 64381097 |
Intentional product misuse | 18.98 | 10.38 | 129 | 63304 | 72166 | 64363133 |
Helicobacter infection | 18.94 | 10.38 | 7 | 63426 | 38355 | 64396944 |
Melaena | 18.84 | 10.38 | 15 | 63418 | 53533 | 64381766 |
Hyperkalaemia | 18.79 | 10.38 | 45 | 63388 | 101084 | 64334215 |
Osteoporosis | 18.66 | 10.38 | 9 | 63424 | 42071 | 64393228 |
Drug dependence | 18.26 | 10.38 | 73 | 63360 | 33239 | 64402060 |
Intentional product use issue | 18.07 | 10.38 | 42 | 63391 | 95322 | 64339977 |
Pancytopenia | 18.04 | 10.38 | 76 | 63357 | 143233 | 64292066 |
Cholecystitis | 17.85 | 10.38 | 51 | 63382 | 19585 | 64415714 |
Tremor | 17.62 | 10.38 | 223 | 63210 | 148007 | 64287292 |
Inflammation | 17.62 | 10.38 | 23 | 63410 | 65277 | 64370022 |
Uterine perforation | 17.58 | 10.38 | 25 | 63408 | 5795 | 64429504 |
Electrocardiogram QT prolonged | 17.54 | 10.38 | 136 | 63297 | 79312 | 64355987 |
Jaw clicking | 17.48 | 10.38 | 4 | 63429 | 15 | 64435284 |
Reversible cerebral vasoconstriction syndrome | 17.32 | 10.38 | 16 | 63417 | 2326 | 64432973 |
Bradycardia | 17.27 | 10.38 | 59 | 63374 | 118160 | 64317139 |
Coma blister | 17.08 | 10.38 | 7 | 63426 | 229 | 64435070 |
Respiratory rate increased | 17.04 | 10.38 | 48 | 63385 | 18283 | 64417016 |
Fear | 17.00 | 10.38 | 51 | 63382 | 20120 | 64415179 |
Gallbladder cholesterolosis | 16.65 | 10.38 | 9 | 63424 | 554 | 64434745 |
Cough | 16.49 | 10.38 | 204 | 63229 | 301944 | 64133355 |
Blood pressure fluctuation | 16.47 | 10.38 | 16 | 63417 | 51855 | 64383444 |
Angioedema | 16.45 | 10.38 | 22 | 63411 | 61799 | 64373500 |
Obsessive thoughts | 16.38 | 10.38 | 11 | 63422 | 1006 | 64434293 |
General symptom | 16.05 | 10.38 | 15 | 63418 | 2213 | 64433086 |
Arthritis | 15.81 | 10.38 | 37 | 63396 | 83777 | 64351522 |
Stomatitis | 15.81 | 10.38 | 55 | 63378 | 109550 | 64325749 |
Neutropenia | 15.77 | 10.38 | 155 | 63278 | 239469 | 64195830 |
Hepatitis | 15.74 | 10.38 | 13 | 63420 | 45569 | 64389730 |
Psychomotor hyperactivity | 15.61 | 10.38 | 40 | 63393 | 14411 | 64420888 |
Finger amputation | 15.60 | 10.38 | 9 | 63424 | 629 | 64434670 |
Toxic epidermal necrolysis | 14.94 | 10.38 | 9 | 63424 | 37157 | 64398142 |
Anhedonia | 14.87 | 10.38 | 38 | 63395 | 13668 | 64421631 |
Impaired gastric emptying | 14.72 | 10.38 | 29 | 63404 | 8775 | 64426524 |
Seizure | 14.62 | 10.38 | 238 | 63195 | 166654 | 64268645 |
Confusional state | 14.31 | 10.38 | 347 | 63086 | 260797 | 64174502 |
Folliculitis | 14.01 | 10.38 | 6 | 63427 | 30071 | 64405228 |
Pulmonary fibrosis | 13.86 | 10.38 | 6 | 63427 | 29872 | 64405427 |
Biliary colic | 13.81 | 10.38 | 17 | 63416 | 3427 | 64431872 |
Pneumocystis jirovecii pneumonia | 13.72 | 10.38 | 5 | 63428 | 27629 | 64407670 |
Gas gangrene | 13.63 | 10.38 | 6 | 63427 | 235 | 64435064 |
Therapeutic response decreased | 13.45 | 10.38 | 19 | 63414 | 52169 | 64383130 |
Red blood cell sedimentation rate increased | 13.37 | 10.38 | 7 | 63426 | 31228 | 64404071 |
Chest pain | 13.36 | 10.38 | 315 | 63118 | 235665 | 64199634 |
Prolonged rupture of membranes | 13.27 | 10.38 | 4 | 63429 | 51 | 64435248 |
Respiratory rate decreased | 13.14 | 10.38 | 19 | 63414 | 4472 | 64430827 |
Aggression | 13.04 | 10.38 | 84 | 63349 | 46148 | 64389151 |
Arm amputation | 13.00 | 10.38 | 5 | 63428 | 138 | 64435161 |
Fear of disease | 12.71 | 10.38 | 9 | 63424 | 896 | 64434403 |
Differential white blood cell count abnormal | 12.68 | 10.38 | 12 | 63421 | 1798 | 64433501 |
Extrapyramidal disorder | 12.50 | 10.38 | 45 | 63388 | 19507 | 64415792 |
Psoriasis | 12.47 | 10.38 | 33 | 63400 | 71670 | 64363629 |
Hypophagia | 12.47 | 10.38 | 74 | 63359 | 39513 | 64395786 |
Blood potassium decreased | 12.39 | 10.38 | 75 | 63358 | 40324 | 64394975 |
Jugular vein thrombosis | 12.38 | 10.38 | 17 | 63416 | 3814 | 64431485 |
Hypoglycaemia | 12.37 | 10.38 | 46 | 63387 | 89846 | 64345453 |
Heart rate decreased | 12.35 | 10.38 | 22 | 63411 | 55045 | 64380254 |
Psychological trauma | 12.32 | 10.38 | 10 | 63423 | 1222 | 64434077 |
Blastocystis infection | 12.26 | 10.38 | 3 | 63430 | 16 | 64435283 |
Inappropriate schedule of product administration | 12.20 | 10.38 | 48 | 63385 | 92238 | 64343061 |
Sopor | 12.18 | 10.38 | 7 | 63426 | 29654 | 64405645 |
Lymphopenia | 12.14 | 10.38 | 5 | 63428 | 25652 | 64409647 |
Dyspnoea | 12.05 | 10.38 | 581 | 62852 | 718093 | 63717206 |
Leukopenia | 11.94 | 10.38 | 55 | 63378 | 101187 | 64334112 |
Inadequate analgesia | 11.89 | 10.38 | 17 | 63416 | 3961 | 64431338 |
Malaise | 11.55 | 10.38 | 299 | 63134 | 395948 | 64039351 |
Loss of personal independence in daily activities | 11.38 | 10.38 | 35 | 63398 | 72419 | 64362880 |
Gallbladder enlargement | 11.29 | 10.38 | 10 | 63423 | 1376 | 64433923 |
Base excess increased | 11.29 | 10.38 | 4 | 63429 | 87 | 64435212 |
Angina pectoris | 11.05 | 10.38 | 17 | 63416 | 45064 | 64390235 |
Withdrawal syndrome | 10.95 | 10.38 | 49 | 63384 | 23443 | 64411856 |
Postpartum haemorrhage | 10.92 | 10.38 | 10 | 63423 | 1437 | 64433862 |
CSF pressure increased | 10.85 | 10.38 | 5 | 63428 | 218 | 64435081 |
Cholecystitis acute | 10.81 | 10.38 | 30 | 63403 | 11330 | 64423969 |
Upper respiratory tract irritation | 10.81 | 10.38 | 4 | 63429 | 99 | 64435200 |
Panic attack | 10.76 | 10.38 | 45 | 63388 | 20908 | 64414391 |
Atrial fibrillation | 10.70 | 10.38 | 112 | 63321 | 170977 | 64264322 |
Transverse sinus thrombosis | 10.69 | 10.38 | 7 | 63426 | 613 | 64434686 |
Drug eruption | 10.52 | 10.38 | 12 | 63421 | 36124 | 64399175 |
Urinary hesitation | 10.49 | 10.38 | 15 | 63418 | 3495 | 64431804 |
Anticholinergic syndrome | 10.43 | 10.38 | 13 | 63420 | 2656 | 64432643 |
Failure to thrive | 10.42 | 10.38 | 28 | 63405 | 10376 | 64424923 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pleural effusion | 46.94 | 28.12 | 11 | 214 | 11 | 84442 |
Pulmonary haemorrhage neonatal | 42.65 | 28.12 | 10 | 215 | 10 | 84443 |
Congenital tricuspid valve incompetence | 32.45 | 28.12 | 10 | 215 | 46 | 84407 |
Source | Code | Description |
---|---|---|
ATC | D04AA10 | DERMATOLOGICALS ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. Antihistamines for topical use |
ATC | R06AD02 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Phenothiazine derivatives |
ATC | R06AD52 | RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Phenothiazine derivatives |
ATC | V03AB05 | VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Antidotes |
FDA CS | M0016525 | Phenothiazines |
MeSH PA | D018926 | Anti-Allergic Agents |
MeSH PA | D000982 | Antipruritics |
MeSH PA | D003879 | Dermatologic Agents |
MeSH PA | D018494 | Histamine Agents |
MeSH PA | D006633 | Histamine Antagonists |
MeSH PA | D006634 | Histamine H1 Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
CHEBI has role | CHEBI:35717 | hypnotics |
CHEBI has role | CHEBI:36333 | local anesthetics |
CHEBI has role | CHEBI:37955 | H1 receptor antagonists |
CHEBI has role | CHEBI:50857 | anti-allergic drugs |
CHEBI has role | CHEBI:50919 | antiemetico |
CHEBI has role | CHEBI:59683 | antipruritic drugs |
CHEBI has role | CHEBI:149553 | anticoronaviral drug |
CHEBI has role | CHEBI:176497 | geroprotectors |
FDA EPC | N0000175746 | Phenothiazine |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
Nausea and vomiting | indication | 16932000 | |
General anesthesia | indication | 50697003 | |
Sedation | indication | 72641008 | |
Urticaria | indication | 126485001 | |
Seasonal allergic rhinitis | indication | 367498001 | |
Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.19 | Basic |
pKa2 | 3.55 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Histamine H1 receptor | GPCR | ANTAGONIST | Ki | 9.62 | WOMBAT-PK | CHEMBL | |||
D(2) dopamine receptor | GPCR | Ki | 6.61 | WOMBAT-PK | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 6.59 | DRUG MATRIX | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.92 | DRUG MATRIX | |||||
Sodium-dependent serotonin transporter | Transporter | IC50 | 5.12 | CHEMBL | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.38 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 5.83 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 6.77 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 7.37 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 8.19 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 5.95 | DRUG MATRIX | |||||
Alpha-1A adrenergic receptor | GPCR | WOMBAT-PK | |||||||
Alpha-2B adrenergic receptor | GPCR | Ki | 7.62 | DRUG MATRIX | |||||
D(3) dopamine receptor | GPCR | Ki | 6.72 | DRUG MATRIX | |||||
Histamine H2 receptor | GPCR | Ki | 5.94 | DRUG MATRIX | |||||
Histamine H4 receptor | GPCR | Ki | 6.82 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 8.48 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 7.92 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 8.38 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M4 | GPCR | Ki | 8.98 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 8.48 | DRUG MATRIX | |||||
Aldehyde oxidase | Enzyme | IC50 | 6.29 | WOMBAT-PK | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 6.45 | DRUG MATRIX | |||||
Cytochrome P450 2D6 | Enzyme | Ki | 5.42 | WOMBAT-PK | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 7.50 | DRUG MATRIX | |||||
Cholinesterase | Enzyme | Ki | 7.10 | WOMBAT-PK | |||||
Major prion protein | Surface antigen | EC50 | 5.10 | CHEMBL | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.45 | CHEMBL | |||||
Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 5.16 | CHEMBL | |||||
FAD-linked sulfhydryl oxidase ALR | Enzyme | AC50 | 6.44 | CHEMBL | |||||
D(1A) dopamine receptor | GPCR | Ki | 5.86 | DRUG MATRIX | |||||
Calmodulin-1 | Cytosolic other | IC50 | 4.22 | CHEMBL | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 7.68 | DRUG MATRIX | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 7.10 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | IC50 | 5.59 | CHEMBL | |||||
Pleiotropic ABC efflux transporter of multiple drugs | Transporter | IC50 | 4.75 | CHEMBL | |||||
Chloroquine resistance transporter | Transporter | IC50 | 4.07 | CHEMBL | |||||
Calmodulin | Cytosolic other | Kd | 4.30 | CHEMBL |
ID | Source |
---|---|
4019910 | VUID |
N0000147995 | NUI |
D00480 | KEGG_DRUG |
58-33-3 | SECONDARY_CAS_RN |
4017846 | VANDF |
4019910 | VANDF |
C0033405 | UMLSCUI |
CHEBI:8461 | CHEBI |
CHEMBL1200750 | ChEMBL_ID |
CHEMBL251904 | ChEMBL_ID |
CHEMBL643 | ChEMBL_ID |
DB01069 | DRUGBANK_ID |
D011398 | MESH_DESCRIPTOR_UI |
4927 | PUBCHEM_CID |
7282 | IUPHAR_LIGAND_ID |
516 | INN_ID |
FF28EJQ494 | UNII |
142445 | RXNORM |
2141 | MMSL |
5367 | MMSL |
d00787 | MMSL |
001483 | NDDF |
004459 | NDDF |
14905007 | SNOMEDCT_US |
372871004 | SNOMEDCT_US |
8372007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
PROMETHAZINE HYDROCHLORIDE AND CODEINE PHOSPHATE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-0547 | SYRUP | 6.25 mg | ORAL | ANDA | 30 sections |
Promethazine VC with Codeine Oral Solution | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0121-0925 | SOLUTION | 6.25 mg | ORAL | ANDA | 29 sections |
Promethazine VC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-0926 | SOLUTION | 6.25 mg | ORAL | ANDA | 25 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0927 | SOLUTION | 6.25 mg | ORAL | ANDA | 25 sections |
Promethazine with Codeine | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-0928 | SOLUTION | 6.25 mg | ORAL | ANDA | 29 sections |
PROMETHAZINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9940 | INJECTION | 25 mg | INTRAMUSCULAR | ANDA | 12 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9941 | INJECTION | 25 mg | INTRAMUSCULAR | ANDA | 12 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9942 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 12 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-5195 | TABLET | 25 mg | ORAL | ANDA | 11 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-8195 | TABLET | 25 mg | ORAL | ANDA | 12 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-5307 | TABLET | 25 mg | ORAL | ANDA | 24 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-5319 | TABLET | 50 mg | ORAL | ANDA | 24 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8154 | TABLET | 25 mg | ORAL | ANDA | 21 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-0928 | INJECTION | 25 mg | INTRAMUSCULAR | ANDA | 25 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-0928 | INJECTION | 25 mg | INTRAMUSCULAR | ANDA | 25 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-0929 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 25 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-0929 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 25 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-0948 | INJECTION | 25 mg | INTRAMUSCULAR | ANDA | 25 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-0949 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 25 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-0955 | INJECTION | 25 mg | INTRAMUSCULAR | ANDA | 25 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-0955 | INJECTION | 25 mg | INTRAMUSCULAR | ANDA | 25 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-0956 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 25 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-0956 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 25 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-1495 | INJECTION | 25 mg | INTRAMUSCULAR | ANDA | 25 sections |
Promethazine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-1496 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 25 sections |
PHENERGAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6082 | INJECTION | 25 mg | INTRAMUSCULAR | ANDA | 25 sections |
PHENERGAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6083 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 25 sections |
PHENERGAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6084 | INJECTION | 25 mg | INTRAMUSCULAR | ANDA | 26 sections |
PHENERGAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6084 | INJECTION | 25 mg | INTRAMUSCULAR | ANDA | 26 sections |
PHENERGAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6085 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 26 sections |