Scroll

mepyramine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2331	91-84-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: pyrilamine pyrilamine maleate pyranisamine mepyramine	A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies. Molecular weight: 285.39 Formula: C17H23N3O CLOGP: 3.23 LIPINSKI: 0 HAC: 4 HDO: 0 TPSA: 28.60 ALOGS: -2.56 ROTB: 7 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

pyrilamine
pyrilamine maleate
pyranisamine
mepyramine

A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.

Molecular weight: 285.39
Formula: C17H23N3O
CLOGP: 3.23
LIPINSKI: 0
HAC: 4
HDO: 0
TPSA: 28.60
ALOGS: -2.56
ROTB: 7

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.20	g	O
0.20	g	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Aug. 7, 1973	FDA	IMPAX LABS

FDA Adverse Event Reporting System (Female)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Total lung capacity decreased	42.55	32.51	9	850	2174	63485989
Lung opacity	39.21	32.51	9	850	3159	63485004
Bronchopulmonary aspergillosis allergic	36.61	32.51	8	851	2250	63485913

Showing 1 to 3 of 3 entries

Previous1Next

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Total lung capacity decreased	43.38	32.35	9	731	2896	79740752
Lung opacity	38.20	32.35	9	731	5165	79738483
Bronchopulmonary aspergillosis allergic	37.20	32.35	8	732	3053	79740595
Pulmonary mass	33.92	32.35	12	728	29022	79714626

Showing 1 to 4 of 4 entries

Previous1Next

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Show entries

Search:

Source	Code	Description
ATC	D04AA02	DERMATOLOGICALS ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. Antihistamines for topical use
ATC	R06AC01	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Substituted ethylene diamines
CHEBI has role	CHEBI:37955	H1 receptor antagonists
MeSH PA	D018926	Anti-Allergic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018494	Histamine Agents
MeSH PA	D006633	Histamine Antagonists
MeSH PA	D006634	Histamine H1 Antagonists
MeSH PA	D006993	Hypnotics and Sedatives

Showing 1 to 10 of 12 entries

Previous1 2Next

Drug Use | Suggest Off label Use Form| |View source of the data|

Show entries

Search:

Disease	Relation	SNOMED_ID	DOID
Sinus headache	indication	4969004
Dermatographic urticaria	indication	7632005	DOID:743
Vasomotor rhinitis	indication	8229003	DOID:4730
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Sneezing	indication	76067001
Common cold	indication	82272006	DOID:10459
Urticaria	indication	126485001
Dysmenorrhea	indication	266599000

Showing 1 to 10 of 102 entries

Previous1 2 3 4 5…11Next

🐶 Veterinary Drug Use

Species	Use	Relation
Horses	Antihistaminic therapy	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Histavet-P	Intervet Inc.	1
Pyrilamine Maleate Injection	Bimeda Animal Health Limited	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.62	Basic
pKa2	4.33	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Show entries

Search:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN	ANTAGONIST	Ki	9.10	CHEMBL	CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	6.18	DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	5.96	CHEMBL
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	7.60	DRUG MATRIX
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	5.70	PDSP
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	5.75	DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	6.23	DRUG MATRIX
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	6.16	DRUG MATRIX
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	6.52	DRUG MATRIX
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN		IC50	8.89	CHEMBL

Showing 1 to 10 of 13 entries

Previous1 2Next

External reference:

Show entries

Search:

ID	Source
003377	NDDF
004791	NDDF
106	INN_ID
1227	IUPHAR_LIGAND_ID
349962001	SNOMEDCT_US
36516003	SNOMEDCT_US
387087002	SNOMEDCT_US
4018202	VANDF
4019923	VUID
4019923	VANDF

Showing 1 to 10 of 25 entries

Previous1 2 3Next

Pharmaceutical products:

Show entries

Search:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Acetaminophen 500mg Caffeine 60mg Pyrilamine maleate 15mg	HUMAN OTC DRUG LABEL	3	0363-2310	TABLET	15 mg	ORAL	OTC monograph not final	8 sections
Acetaminophen 500mg Caffeine 60mg Pyrilamine maleate 15mg	HUMAN OTC DRUG LABEL	3	0363-2310	TABLET	15 mg	ORAL	OTC monograph not final	8 sections
Acetaminophen 500mg Caffeine 60mg Pyrilamine maleate 15mg	HUMAN OTC DRUG LABEL	3	0363-2310	TABLET	15 mg	ORAL	OTC monograph not final	8 sections
Acetaminophen,Caffeine and Pyrilamine Maleate	HUMAN OTC DRUG LABEL	3	24689-121	TABLET	15 mg	ORAL	OTC monograph not final	12 sections
Acetaminophen,Caffeine and Pyrilamine Maleate	HUMAN OTC DRUG LABEL	3	24689-121	TABLET	15 mg	ORAL	OTC monograph not final	12 sections
Menstrual Complete Pain Relief	HUMAN OTC DRUG LABEL	3	0363-9390	TABLET, FILM COATED	15 mg	ORAL	OTC monograph not final	16 sections
Menstrual Complete Pain Relief	HUMAN OTC DRUG LABEL	3	0363-9390	TABLET, FILM COATED	15 mg	ORAL	OTC monograph not final	16 sections
Menstrual CompleteMaximum Strength	HUMAN OTC DRUG LABEL	3	11822-0390	TABLET, FILM COATED	15 mg	ORAL	OTC monograph not final	16 sections
Menstrual CompleteMaximum Strength	HUMAN OTC DRUG LABEL	3	11822-0390	TABLET, FILM COATED	15 mg	ORAL	OTC monograph not final	16 sections
Menstrual Pain Relief	HUMAN OTC DRUG LABEL	3	0363-3900	TABLET, FILM COATED	15 mg	ORAL	OTC monograph not final	16 sections

Showing 1 to 10 of 30 entries

Previous1 2 3Next