DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
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L1000
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
bilastine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
antihistaminics
4353
202189-78-4
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
bellozal
F-96221-BM1
bilastine
bilaxten
Molecular weight: 463.62
Formula: C28H37N3O3
CLOGP: 1.95
LIPINSKI: 0
HAC: 6
HDO: 1
TPSA: 67.59
ALOGS: -5.36
ROTB: 10
Drug dosage:
Dose
Unit
Route
20
mg
O
ADMET properties:
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Property
Value
Reference
t_half (Half-life)
5.16 hours
Lombardo F, Berellini G, Obach RS
CL (Clearance)
2.87 mL/min/kg
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.61 L/kg
Lombardo F, Berellini G, Obach RS
BA (Bioavailability)
0.61 %
Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
fu (Fraction unbound in plasma)
0.13 %
Lombardo F, Berellini G, Obach RS
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Approvals:
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Date
Agency
Company
Orphan
None
PMDA
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FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Urticaria
358.49
22.41
230
7292
165572
63315928
Pruritus
154.30
22.41
201
7321
361252
63120248
Angioedema
104.24
22.41
67
7455
47898
63433602
Chronic spontaneous urticaria
89.89
22.41
22
7500
1135
63480365
Skin plaque
87.44
22.41
34
7488
8286
63473214
Inappropriate schedule of product administration
65.92
22.41
71
7451
103894
63377606
Erythema
59.96
22.41
88
7434
175663
63305837
Urticaria thermal
58.84
22.41
13
7509
426
63481074
Urticaria chronic
58.61
22.41
14
7508
651
63480849
Scratch
52.34
22.41
22
7500
6543
63474957
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6
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FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Urticaria
130.16
27.21
66
1964
62311
34892590
Angioimmunoblastic T-cell lymphoma
58.63
27.21
11
2019
328
34954573
Angioedema
56.50
27.21
32
1998
37342
34917559
Rash maculovesicular
50.03
27.21
7
2023
28
34954873
Pruritus
48.80
27.21
50
1980
141931
34812970
Lip erythema
45.59
27.21
7
2023
59
34954842
Urticaria chronic
42.97
27.21
7
2023
89
34954812
Nasal mucosal disorder
40.74
27.21
7
2023
125
34954776
Enanthema
32.52
27.21
7
2023
421
34954480
Lichenoid keratosis
32.46
27.21
10
2020
2498
34952403
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Urticaria
425.53
19.49
265
8985
184936
79550202
Pruritus
190.56
19.49
231
9019
394417
79340721
Angioedema
121.29
19.49
87
9163
75948
79659190
Chronic spontaneous urticaria
104.45
19.49
25
9225
1199
79733939
Skin plaque
89.77
19.49
37
9213
10708
79724430
Inappropriate schedule of product administration
80.60
19.49
88
9162
133540
79601598
Erythema
69.62
19.49
106
9144
223184
79511954
Asthma
66.32
19.49
80
9170
135015
79600123
Urticaria thermal
64.50
19.49
14
9236
431
79734707
Illness
58.07
19.49
46
9204
46465
79688673
Showing 1 to 10 of 63 entries
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7
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
R06AX29
RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Other antihistamines for systemic use
ATC
S01GX13
SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Other antiallergics
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Allergic rhinitis
indication
61582004
Urticaria
indication
126485001
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
4.42
acidic
pKa2
7.88
Basic
pKa3
5.11
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Histamine H1 receptor
GPCR
P35367
HRH1_HUMAN
ANTAGONIST
Ki
7.19
SCIENTIFIC LITERATURE
SCIENTIFIC LITERATURE
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External reference:
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ID
Source
013709
NDDF
11579
IUPHAR_LIGAND_ID
185460
PUBCHEM_CID
697973006
SNOMEDCT_US
714622001
SNOMEDCT_US
7905
INN_ID
C1101148
UMLSCUI
C445659
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135954
CHEBI
CHEMBL1742423
ChEMBL_ID
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Pharmaceutical products:
None
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bilastine