thenalidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2617 86-12-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thenalidine
  • thenaldine
  • thenalidin
  • thenophenopiperidine
antihistaminic, antipruritic; RN in Chemline for thenalidine calcium: 67250-62-8; structure
  • Molecular weight: 286.44
  • Formula: C17H22N2S
  • CLOGP: 3.78
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 6.48
  • ALOGS: -3.51
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAP4K3,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK 52
kinase-selectivity-class AKT3,ALK,AXL,CAMK2D,DDR1,EPHB4,ERBB2,PDK4,PRKCD,SIK2,SIK3,STK33,TEK,TTK 14
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D04AA03 DERMATOLOGICALS
ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
Antihistamines for topical use
ATC R06AX03 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Other antihistamines for systemic use
ATC R06AX53 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Other antihistamines for systemic use

Related Drugs by ATC class:

D04AA Antihistamines for topical use 13 drugs
bamipinechloropyraminechlorphenoxamineclemastinedimetindenediphenhydramineisothipendylmepyraminepheniraminepromethazinethonzylaminetolpropamine show all 13 →
R06AX Other antihistamines for systemic use 26 drugs
acrivastineantazolineastemizoleazatadineazelastinebamipinebilastinecyproheptadinedeptropinedesloratadineebastineepinastine show all 26 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.35 Basic
pKa2 5.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07194 KEGG_DRUG
C0076382 UMLSCUI
CHEBI:135187 CHEBI
CHEMBL2105458 ChEMBL_ID
DB04826 DRUGBANK_ID
C005795 MESH_SUPPLEMENTAL_RECORD_UI
27901 PUBCHEM_CID
678 INN_ID
6U94N2D00F UNII
6U94N2D00F INXIGHT DRUGS

Pharmaceutical products:

None