colecalciferol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 2840 67-97-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Vitamin D3
  • cholecalciferol
  • arachitol
  • calciol
  • calcirol
  • colecalciferol
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24. Some experts recommend maintaining recommended levels of vitamin D intake during the COVID-19 pandemic to maintain bone and muscle health and avoid deficiency. Efficacy of vitamin D supplementation in the prevention or treatment of COVID-19 has not been established.
  • Molecular weight: 384.65
  • Formula: C27H44O
  • CLOGP: 9.48
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -6.01
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mcg O
10 mg O
5 mg O
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.10 mg/mL Benet LZ, Broccatelli F, Oprea TI

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,STK33,TEK,TGFBR1 29
kinase-selectivity-class GRK2 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
May 18, 2000 FDA SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1436.14 10.10 1011 1187922 286835 89152679
Completed suicide 1401.57 10.10 139 1188794 144919 89294595
Intentional overdose 715.07 10.10 175 1188758 93659 89345855
Drug abuse 594.43 10.10 171 1188762 82176 89357338
Systemic lupus erythematosus 578.15 10.10 7270 1181663 354626 89084888
Pemphigus 563.18 10.10 6661 1182272 320203 89119311
Death 518.71 10.10 3681 1185252 452870 88986644
Alopecia 485.03 10.10 9153 1179780 485918 88953596
Glossodynia 475.86 10.10 6374 1182559 315405 89124109
Overdose 467.92 10.10 845 1188088 156864 89282650
Drug interaction 444.07 10.10 1989 1186944 274464 89165050
Abdominal discomfort 431.94 10.10 8720 1180213 468608 88970906
Arthropathy 419.65 10.10 6943 1181990 359299 89080215
Suicide attempt 416.63 10.10 235 1188698 75164 89364350
Depressed level of consciousness 372.72 10.10 248 1188685 72536 89366978
Hand deformity 359.02 10.10 5671 1183262 290691 89148823
Cardiac arrest 348.73 10.10 522 1188411 104413 89335101
Febrile neutropenia 323.13 10.10 1033 1187900 157316 89282198
Malignant neoplasm progression 307.72 10.10 583 1188350 106287 89333227
Myelosuppression 304.85 10.10 161 1188772 53430 89386084
Wound 299.03 10.10 5610 1183323 297370 89142144
Pain 291.82 10.10 15911 1173022 980430 88459084
Arthralgia 262.87 10.10 12605 1176328 765917 88673597
Disease progression 254.80 10.10 1121 1187812 155494 89284020
Femur fracture 252.66 10.10 1236 1187697 44846 89394668
Coma 246.50 10.10 356 1188577 72276 89367238
Fatigue 245.17 10.10 17925 1171008 1136098 88303416
Maternal exposure during pregnancy 234.31 10.10 6284 1182649 353779 89085735
Drug ineffective for unapproved indication 230.78 10.10 322 1188611 66322 89373192
Sedation 222.23 10.10 183 1188750 47988 89391526
Swelling 218.12 10.10 7113 1181820 411945 89027569
Anti-cyclic citrullinated peptide antibody positive 216.23 10.10 4328 1184605 232105 89207409
Joint swelling 215.38 10.10 8354 1180579 494946 88944568
Serotonin syndrome 209.41 10.10 118 1188815 37769 89401745
Cardio-respiratory arrest 207.91 10.10 316 1188617 62824 89376690
Hepatic function abnormal 207.23 10.10 181 1188752 46107 89393407
Discomfort 202.88 10.10 4871 1184062 269464 89170050
Drug hypersensitivity 194.62 10.10 4613 1184320 458996 88980518
Hypotension 193.04 10.10 3053 1185880 322344 89117170
Synovitis 190.78 10.10 5670 1183263 324082 89115432
Pericarditis 190.55 10.10 4766 1184167 265385 89174129
Drug reaction with eosinophilia and systemic symptoms 186.86 10.10 171 1188762 42587 89396927
Lactic acidosis 185.78 10.10 233 1188700 50230 89389284
Drug resistance 182.96 10.10 85 1188848 30364 89409150
Poisoning deliberate 181.92 10.10 8 1188925 16478 89423036
Neutropenia 170.11 10.10 2008 1186925 222896 89216618
Respiratory arrest 169.86 10.10 114 1188819 33197 89406317
Rheumatoid arthritis 162.60 10.10 6051 1182882 356563 89082951
Acute kidney injury 150.89 10.10 3130 1185803 317257 89122257
Multiple organ dysfunction syndrome 147.74 10.10 434 1188499 67902 89371612
Intentional self-injury 146.10 10.10 103 1188830 29231 89410283
Contraindicated product administered 145.86 10.10 5352 1183581 314787 89124727
Anaphylactic reaction 143.80 10.10 624 1188309 86900 89352614
Duodenal ulcer perforation 143.47 10.10 3861 1185072 217427 89222087
Low turnover osteopathy 140.38 10.10 221 1188712 3997 89435517
Psoriatic arthropathy 136.27 10.10 3942 1184991 224393 89215121
Agitation 134.53 10.10 441 1188492 66657 89372857
Musculoskeletal stiffness 131.59 10.10 4943 1183990 291589 89147925
Renal failure 129.75 10.10 1096 1187837 129911 89309603
Rhabdomyolysis 129.54 10.10 301 1188632 50955 89388559
Device expulsion 129.50 10.10 210 1188723 40676 89398838
Temperature regulation disorder 128.40 10.10 19 1188914 14560 89424954
Sedation complication 128.28 10.10 32 1188901 16912 89422602
Helicobacter infection 126.87 10.10 3885 1185048 222965 89216549
Thrombocytopenia 125.48 10.10 1953 1186980 206772 89232742
Infusion related reaction 125.07 10.10 6675 1182258 410105 89029409
Metabolic acidosis 122.25 10.10 351 1188582 55325 89384189
Nasopharyngitis 119.75 10.10 6508 1182425 400596 89038918
Drug ineffective 119.49 10.10 16132 1172801 1368166 88071348
Intentional product misuse 118.53 10.10 689 1188244 88915 89350599
Hyperhidrosis 118.24 10.10 1179 1187754 135126 89304388
Respiratory failure 117.58 10.10 990 1187943 117428 89322086
Somnolence 116.53 10.10 1984 1186949 207100 89232414
Altered state of consciousness 115.64 10.10 146 1188787 31386 89408128
Creatinine renal clearance decreased 114.73 10.10 52 1188881 18847 89420667
Mydriasis 114.33 10.10 28 1188905 14984 89424530
Bradycardia 114.00 10.10 639 1188294 83208 89356306
Angioedema 113.75 10.10 451 1188482 64425 89375089
Cardiac failure 113.46 10.10 905 1188028 108591 89330923
Hepatic failure 112.34 10.10 219 1188714 39509 89400005
Shock 112.20 10.10 127 1188806 28651 89410863
Osteoarthritis 108.08 10.10 3347 1185586 192383 89247131
Rheumatoid factor positive 106.43 10.10 2978 1185955 168672 89270842
Anaphylactic shock 102.39 10.10 160 1188773 31457 89408057
Intramedullary rod insertion 101.95 10.10 134 1188799 2038 89437476
Ventricular tachycardia 101.93 10.10 104 1188829 24604 89414910
Impaired healing 101.48 10.10 3894 1185039 230305 89209209
Sickle cell anaemia with crisis 100.57 10.10 265 1188668 7032 89432482
Neurologic neglect syndrome 98.60 10.10 4 1188929 8843 89430671
Poisoning 96.96 10.10 39 1188894 15178 89424336
Cytomegalovirus infection 96.70 10.10 124 1188809 26478 89413036
Food allergy 96.56 10.10 115 1188818 25363 89414151
Respiratory depression 95.89 10.10 42 1188891 15533 89423981
No adverse event 95.76 10.10 512 1188421 67470 89372044
Acute hepatic failure 95.33 10.10 93 1188840 22468 89417046
Sinusitis 95.04 10.10 5455 1183478 337633 89101881
Vitamin D deficiency 92.75 10.10 466 1188467 17090 89422424
Tachycardia 91.16 10.10 1486 1187447 156187 89283327
Product use issue 90.10 10.10 5239 1183694 324680 89114834
Cognitive disorder 90.04 10.10 537 1188396 68870 89370644
Personality disorder 89.49 10.10 26 1188907 12418 89427096
Pain in extremity 89.42 10.10 6965 1181968 443564 88995950
Hepatotoxicity 88.00 10.10 307 1188626 45535 89393979
Electrocardiogram QT prolonged 87.58 10.10 573 1188360 71883 89367631
Product use in unapproved indication 85.90 10.10 3571 1185362 332665 89106849
Carotid artery thrombosis 84.49 10.10 10 1188923 9082 89430432
Seizure 83.18 10.10 1454 1187479 151175 89288339
Red blood cell sedimentation rate abnormal 82.22 10.10 572 1188361 23632 89415882
Myocardial infarction 81.67 10.10 942 1187991 105030 89334484
Knee arthroplasty 81.46 10.10 1539 1187394 81643 89357871
Posterior reversible encephalopathy syndrome 80.30 10.10 105 1188828 22234 89417280
Torsade de pointes 80.07 10.10 50 1188883 15132 89424382
Cytokine release syndrome 79.27 10.10 154 1188779 27819 89411695
Palmar-plantar erythrodysaesthesia syndrome 78.78 10.10 155 1188778 27868 89411646
Ventricular fibrillation 77.24 10.10 44 1188889 14000 89425514
Hypoglycaemia 77.21 10.10 567 1188366 69281 89370233
Metastases to central nervous system 76.83 10.10 70 1188863 17472 89422042
Peripheral swelling 76.68 10.10 6354 1182579 406752 89032762
Drug dependence 75.91 10.10 170 1188763 29157 89410357
Dysarthria 75.81 10.10 412 1188521 54070 89385444
Sopor 74.88 10.10 130 1188803 24514 89415000
Extrapyramidal disorder 73.88 10.10 63 1188870 16240 89423274
Schizoaffective disorder 73.06 10.10 189 1188744 4958 89434556
Vomiting 72.90 10.10 9143 1179790 779150 88660364
Drug withdrawal syndrome 71.52 10.10 170 1188763 28553 89410961
Encephalopathy 70.98 10.10 340 1188593 46104 89393410
Hypomania 70.95 10.10 15 1188918 8882 89430632
Hip arthroplasty 70.89 10.10 1399 1187534 74809 89364705
Psychotic disorder 70.69 10.10 194 1188739 31036 89408478
Status epilepticus 70.67 10.10 86 1188847 18788 89420726
Brain oedema 69.67 10.10 75 1188858 17310 89422204
Foot fracture 69.30 10.10 591 1188342 26015 89413499
Neutrophil count decreased 68.77 10.10 603 1188330 70929 89368585
Thrombotic microangiopathy 68.74 10.10 63 1188870 15680 89423834
Stevens-Johnson syndrome 68.37 10.10 180 1188753 29196 89410318
Cardiogenic shock 68.21 10.10 136 1188797 24332 89415182
Tooth disorder 67.98 10.10 665 1188268 30425 89409089
Open reduction of fracture 67.87 10.10 80 1188853 1082 89438432
Hemiplegia 67.83 10.10 67 1188866 16093 89423421
Unresponsive to stimuli 67.47 10.10 264 1188669 37857 89401657
Blood creatine phosphokinase increased 67.24 10.10 225 1188708 33798 89405716
Sepsis 67.00 10.10 1820 1187113 177994 89261520
Exposure to toxic agent 66.55 10.10 12 1188921 7955 89431559
Neurotoxicity 66.36 10.10 112 1188821 21355 89418159
Cardiac failure congestive 66.06 10.10 904 1188029 97790 89341724
Spinal osteoarthritis 65.92 10.10 454 1188479 18694 89420820
Blood cholesterol increased 65.21 10.10 3346 1185587 204666 89234848
Orthostatic hypotension 64.04 10.10 306 1188627 41521 89397993
Nausea 63.60 10.10 13234 1175699 1097082 88342432
Disseminated intravascular coagulation 63.29 10.10 116 1188817 21422 89418092
Therapeutic product effect decreased 63.13 10.10 4339 1184594 273232 89166282
Hepatic enzyme increased 63.06 10.10 5524 1183409 355212 89084302
Contusion 63.05 10.10 3960 1184973 247256 89192258
Adjustment disorder 62.61 10.10 24 1188909 9618 89429896
Unintentional medical device removal 62.29 10.10 9 1188924 7021 89432493
Neuroleptic malignant syndrome 61.76 10.10 64 1188869 15032 89424482
Ejection fraction decreased 60.99 10.10 161 1188772 26092 89413422
Miosis 60.93 10.10 24 1188909 9460 89430054
Acute generalised exanthematous pustulosis 60.83 10.10 54 1188879 13649 89425865
Hypoxia 60.39 10.10 632 1188301 71767 89367747
Fall 60.28 10.10 7211 1181722 474599 88964915
Lower respiratory tract infection 59.60 10.10 3933 1185000 246726 89192788
Coagulopathy 59.46 10.10 136 1188797 23153 89416361
Accidental exposure to product 59.15 10.10 320 1188613 42046 89397468
Ascites 58.98 10.10 375 1188558 47365 89392149
Drug use disorder 58.96 10.10 18 1188915 8325 89431189
Fracture nonunion 58.89 10.10 107 1188826 2185 89437329
Mental status changes 58.84 10.10 344 1188589 44335 89395179
Metastases to bone 58.81 10.10 157 1188776 25348 89414166
Akathisia 58.51 10.10 37 1188896 11122 89428392
Transplant rejection 58.18 10.10 49 1188884 12709 89426805
Cardiotoxicity 58.03 10.10 39 1188894 11350 89428164
Hyponatraemia 57.47 10.10 1323 1187610 132215 89307299
Device difficult to use 57.41 10.10 88 1188845 17437 89422077
Rash erythematous 57.33 10.10 561 1188372 64543 89374971
Basal cell carcinoma 57.13 10.10 680 1188253 32709 89406805
Affect lability 56.99 10.10 93 1188840 17970 89421544
Fracture delayed union 56.94 10.10 111 1188822 2395 89437119
Schizophrenia 56.86 10.10 67 1188866 14847 89424667
Intervertebral disc degeneration 56.21 10.10 404 1188529 16870 89422644
Dyspnoea 56.14 10.10 10442 1178491 870513 88569001
Hyperkalaemia 55.86 10.10 563 1188370 64401 89375113
Loss of consciousness 55.78 10.10 1406 1187527 138832 89300682
Hepatocellular injury 55.53 10.10 194 1188739 28764 89410750
Therapy partial responder 55.25 10.10 130 1188803 21913 89417601
Metastases to liver 55.24 10.10 193 1188740 28614 89410900
Folliculitis 55.14 10.10 3242 1185691 201111 89238403
Acute respiratory distress syndrome 55.13 10.10 192 1188741 28494 89411020
Haematotoxicity 54.92 10.10 50 1188883 12485 89427029
Venoocclusive liver disease 54.69 10.10 7 1188926 5986 89433528
Gangrene 54.49 10.10 53 1188880 12823 89426691
Bronchopulmonary aspergillosis 54.20 10.10 42 1188891 11356 89428158
Wrong technique in product usage process 54.06 10.10 639 1188294 70932 89368582
Suicidal ideation 53.65 10.10 665 1188268 73190 89366324
Joint effusion 53.56 10.10 442 1188491 19268 89420246
Acute graft versus host disease 53.42 10.10 5 1188928 5463 89434051
Nasal polyps 53.14 10.10 39 1188894 10841 89428673
Stress fracture 53.07 10.10 239 1188694 8372 89431142
Multiple-drug resistance 52.79 10.10 18 1188915 7758 89431756
Syncope 52.78 10.10 1330 1187603 131333 89308181
Aspartate aminotransferase increased 52.49 10.10 992 1187941 101945 89337569
Weight increased 52.39 10.10 6256 1182677 411671 89027843
Blood bilirubin increased 51.91 10.10 345 1188588 43125 89396389
Osteoporosis 51.74 10.10 1645 1187288 94886 89344628
Septic shock 51.71 10.10 784 1188149 83376 89356138
Psoriasis 51.16 10.10 2400 1186533 145354 89294160
Arterial occlusive disease 50.65 10.10 53 1188880 12393 89427121
Acute graft versus host disease in skin 50.29 10.10 3 1188930 4753 89434761
Angina pectoris 50.25 10.10 304 1188629 38856 89400658
Toxic skin eruption 49.97 10.10 81 1188852 15693 89423821
International normalised ratio increased 49.50 10.10 390 1188543 46926 89392588
Haemophagocytic lymphohistiocytosis 49.33 10.10 79 1188854 15380 89424134
Anaemia 49.24 10.10 3971 1184962 348831 89090683
Asthma-chronic obstructive pulmonary disease overlap syndrome 49.16 10.10 4 1188929 4895 89434619
Cerebral infarction 49.13 10.10 181 1188752 26415 89413099
Aggression 48.93 10.10 182 1188751 26486 89413028
Platelet count decreased 48.79 10.10 1395 1187538 135574 89303940
Pyrexia 48.54 10.10 7767 1181166 652718 88786796
Bone loss 48.31 10.10 127 1188806 3365 89436149
Face oedema 48.31 10.10 151 1188782 23167 89416347
COVID-19 48.12 10.10 2692 1186241 166151 89273363
Renal impairment 47.76 10.10 1036 1187897 104385 89335129
Pulmonary oedema 47.76 10.10 552 1188381 61528 89377986
Infective pulmonary exacerbation of cystic fibrosis 47.54 10.10 263 1188670 10016 89429498
Bronchospasm 47.36 10.10 128 1188805 20581 89418933
Dystonia 47.30 10.10 93 1188840 16726 89422788
Spinal fracture 47.20 10.10 469 1188464 21547 89417967
Device use error 46.84 10.10 18 1188915 7203 89432311
Interstitial lung disease 46.52 10.10 713 1188220 75692 89363822
Myoclonus 46.50 10.10 115 1188818 19053 89420461
General physical health deterioration 46.26 10.10 5329 1183604 349786 89089728
Vitamin D decreased 46.07 10.10 292 1188641 11687 89427827
Urinary tract infection 45.58 10.10 4628 1184305 301004 89138510
Rheumatic fever 45.54 10.10 2451 1186482 150670 89288844
Graft versus host disease 45.53 10.10 25 1188908 8119 89431395
Juvenile idiopathic arthritis 45.52 10.10 135 1188798 3842 89435672
Metastases to lung 45.34 10.10 88 1188845 15903 89423611
Osteopenia 45.03 10.10 481 1188452 22521 89416993
Chest discomfort 44.89 10.10 1427 1187506 136938 89302576
Emotional distress 44.77 10.10 289 1188644 36373 89403141
Sleep disorder due to general medical condition, insomnia type 44.46 10.10 2090 1186843 126604 89312910
Restlessness 44.43 10.10 280 1188653 35440 89404074
Acute myeloid leukaemia 43.94 10.10 132 1188801 20508 89419006
Intentional product use issue 43.91 10.10 3359 1185574 213533 89225981
Disability assessment scale score increased 43.64 10.10 132 1188801 3799 89435715
Atypical femur fracture 43.22 10.10 183 1188750 6238 89433276
Anaemia postoperative 43.15 10.10 92 1188841 2121 89437393
Coordination abnormal 43.05 10.10 140 1188793 21216 89418298
Hyperglycaemia 42.89 10.10 444 1188489 50526 89388988
Blister 42.86 10.10 3894 1185039 251104 89188410
Asphyxia 42.41 10.10 20 1188913 7083 89432431
Swollen joint count increased 42.13 10.10 1823 1187110 109383 89330131
Stress cardiomyopathy 41.91 10.10 69 1188864 13286 89426228
Alanine aminotransferase increased 41.70 10.10 1207 1187726 117131 89322383
Substance abuse 41.33 10.10 10 1188923 5396 89434118
Irritable bowel syndrome 41.21 10.10 3208 1185725 204240 89235274
Tooth fracture 41.18 10.10 295 1188638 12305 89427209
Fluid retention 40.39 10.10 864 1188069 87227 89352287
Disorientation 40.17 10.10 377 1188556 43737 89395777
Proteinuria 40.14 10.10 163 1188770 23128 89416386
Blood pressure decreased 39.98 10.10 716 1188217 74179 89365335
Mucosal inflammation 39.94 10.10 524 1188409 57101 89382413
Aspergillus infection 39.80 10.10 50 1188883 10773 89428741
Erythema 39.48 10.10 2534 1186399 226712 89212802
Leukopenia 39.43 10.10 1012 1187921 99698 89339816
Cytomegalovirus infection reactivation 39.36 10.10 27 1188906 7773 89431741
Muscle injury 39.35 10.10 2757 1186176 173897 89265617
BK virus infection 39.29 10.10 6 1188927 4492 89435022
Body height decreased 39.19 10.10 280 1188653 11669 89427845
Total lung capacity increased 38.96 10.10 9 1188924 5012 89434502
Epstein-Barr virus infection 38.87 10.10 47 1188886 10297 89429217
Fibromyalgia 38.73 10.10 3176 1185757 203093 89236421
Cytomegalovirus viraemia 38.62 10.10 26 1188907 7560 89431954
Blood pressure diastolic abnormal 38.58 10.10 415 1188518 19466 89420048
Pathogen resistance 38.46 10.10 30 1188903 8085 89431429
Thoracic vertebral fracture 38.41 10.10 158 1188775 5316 89434198
Graft versus host disease in gastrointestinal tract 38.00 10.10 6 1188927 4382 89435132
Sinus tachycardia 37.83 10.10 219 1188714 28294 89411220
Tardive dyskinesia 37.64 10.10 53 1188880 10877 89428637
Obstructive airways disorder 37.45 10.10 193 1188740 25676 89413838
Arthritis 36.88 10.10 2609 1186324 164706 89274808
Lower respiratory tract infection viral 36.69 10.10 54 1188879 918 89438596
Anuria 36.65 10.10 88 1188845 14730 89424784
Wrist fracture 36.54 10.10 339 1188594 15285 89424229
Hypoaesthesia 36.42 10.10 4681 1184252 309529 89129985
Electrocardiogram QRS complex prolonged 36.33 10.10 26 1188907 7322 89432192
Carpal tunnel syndrome 36.09 10.10 476 1188457 23452 89416062
Respiratory acidosis 36.03 10.10 32 1188901 8087 89431427
Inappropriate antidiuretic hormone secretion 35.86 10.10 133 1188800 19372 89420142
Tremor 35.51 10.10 1644 1187289 151529 89287985
Systemic infection 35.23 10.10 140 1188793 4635 89434879
Cerebrovascular accident 35.20 10.10 1295 1187638 122238 89317276
Dysmorphism 35.13 10.10 93 1188840 2475 89437039
Hypothermia 35.07 10.10 97 1188836 15478 89424036
Gastrointestinal haemorrhage 35.03 10.10 908 1188025 89340 89350174
Blood calcium decreased 34.81 10.10 242 1188691 29940 89409574
Blood pressure systolic abnormal 34.79 10.10 400 1188533 19078 89420436
Hallucination 34.76 10.10 632 1188301 65327 89374187
Disease recurrence 34.62 10.10 321 1188612 37332 89402182
Respiratory distress 34.54 10.10 335 1188598 38611 89400903
Aphasia 34.38 10.10 377 1188556 42435 89397079
Genital haemorrhage 34.36 10.10 38 1188895 8664 89430850
Blood pressure fluctuation 34.34 10.10 916 1188017 51497 89388017
Foot deformity 34.21 10.10 1025 1187908 58626 89380888
Pulseless electrical activity 34.19 10.10 40 1188893 8892 89430622
Abortion spontaneous 34.08 10.10 940 1187993 53116 89386398
Fracture 34.07 10.10 441 1188492 21635 89417879
Bone marrow failure 33.97 10.10 265 1188668 31956 89407558
Hypokalaemia 33.96 10.10 1390 1187543 129726 89309788
Human herpesvirus 6 infection 33.90 10.10 3 1188930 3429 89436085
Gamma-glutamyltransferase increased 33.85 10.10 326 1188607 37626 89401888
Anti-neutrophil cytoplasmic antibody positive vasculitis 33.38 10.10 6 1188927 3987 89435527
Tonsillar ulcer 33.36 10.10 30 1188903 288 89439226
Jaundice cholestatic 33.31 10.10 50 1188883 9993 89429521
Mania 33.28 10.10 86 1188847 14038 89425476
Toxic encephalopathy 33.25 10.10 39 1188894 8660 89430854
Cholestasis 33.14 10.10 310 1188623 35989 89403525
Chronic graft versus host disease 32.96 10.10 7 1188926 4132 89435382
Gestational diabetes 32.44 10.10 244 1188689 10338 89429176
Anosognosia 32.42 10.10 4 1188929 3518 89435996
Blood glucose increased 32.18 10.10 977 1187956 94269 89345245
Synovial cyst 32.18 10.10 264 1188669 11488 89428026
Renal injury 32.07 10.10 53 1188880 10190 89429324
Swollen tongue 31.81 10.10 418 1188515 45538 89393976
Neck deformity 31.71 10.10 81 1188852 2108 89437406
Lethargy 31.71 10.10 610 1188323 62529 89376985
Metastases to lymph nodes 31.71 10.10 66 1188867 11623 89427891
Erythema multiforme 31.68 10.10 71 1188862 12175 89427339
Polyarthritis 31.52 10.10 374 1188559 17976 89421538
Pleural effusion 31.46 10.10 1176 1187757 110815 89328699
Injection site pruritus 31.40 10.10 927 1188006 52907 89386607
Toxic epidermal necrolysis 31.35 10.10 274 1188659 32254 89407260
Distributive shock 31.25 10.10 4 1188929 3420 89436094
Bone disorder 31.24 10.10 451 1188482 22669 89416845
Hemiparesis 31.12 10.10 267 1188666 31552 89407962
Small for dates baby 30.88 10.10 139 1188794 4868 89434646
Blood alkaline phosphatase increased 30.88 10.10 444 1188489 47635 89391879
Cardiomyopathy 30.83 10.10 148 1188785 20058 89419456
Product quality issue 30.81 10.10 798 1188135 78527 89360987
Pulmonary embolism 30.74 10.10 1402 1187531 129418 89310096
Bone giant cell tumour 30.43 10.10 16 1188917 55 89439459
Paradoxical drug reaction 30.39 10.10 19 1188914 5747 89433767
Multiple fractures 30.17 10.10 222 1188711 9340 89430174
Dental implantation 30.17 10.10 47 1188886 842 89438672
Cytopenia 30.14 10.10 122 1188811 17327 89422187
Abnormal behaviour 29.91 10.10 174 1188759 22454 89417060
Transplant dysfunction 29.84 10.10 16 1188917 5266 89434248
Ear pain 29.80 10.10 979 1187954 56723 89382791
Cerebral haemorrhage 29.75 10.10 299 1188634 34223 89405291
Maternal exposure during delivery 29.63 10.10 7 1188926 3839 89435675
Eating disorder 29.55 10.10 231 1188702 27842 89411672
Diabetic ketoacidosis 29.50 10.10 193 1188740 24214 89415300
Drug dose omission by device 29.27 10.10 56 1188877 10175 89429339
Adenovirus infection 29.20 10.10 12 1188921 4610 89434904
Dissociation 29.17 10.10 27 1188906 6688 89432826
Ill-defined disorder 29.04 10.10 2810 1186123 182081 89257433
Malignant melanoma 28.98 10.10 272 1188661 12304 89427210
Stomatitis 28.79 10.10 4068 1184865 270630 89168884
Tenderness 28.71 10.10 504 1188429 26364 89413150
Blood pressure systolic increased 28.62 10.10 984 1187949 57361 89382153
Myopathy 28.39 10.10 87 1188846 13431 89426083
Hyperbilirubinaemia 28.34 10.10 91 1188842 13845 89425669
Scoliosis 28.22 10.10 207 1188726 8700 89430814
Myocarditis 28.18 10.10 90 1188843 13716 89425798
Rash maculo-papular 28.08 10.10 373 1188560 40560 89398954
Joint laxity 28.01 10.10 87 1188846 2541 89436973
Bone density abnormal 27.88 10.10 118 1188815 4022 89435492
Jaundice 27.87 10.10 282 1188651 32235 89407279
Pregnancy 27.87 10.10 1036 1187897 61011 89378503
Device dislocation 27.83 10.10 271 1188662 31211 89408303
Bone density decreased 27.83 10.10 349 1188584 16996 89422518
Hepatic cytolysis 27.81 10.10 265 1188668 30651 89408863
Injection site reaction 27.78 10.10 1476 1187457 90604 89348910
Tumour lysis syndrome 27.77 10.10 66 1188867 11086 89428428
Pancreatitis 27.24 10.10 702 1188231 69124 89370390
Purpura 27.01 10.10 101 1188832 14677 89424837
Subarachnoid haemorrhage 26.82 10.10 132 1188801 17772 89421742
Injection site erythema 26.79 10.10 1564 1187369 96938 89342576
Haemodialysis 26.70 10.10 46 1188887 8701 89430813
Haemodynamic instability 26.51 10.10 73 1188860 11666 89427848
Type 2 diabetes mellitus 26.43 10.10 3050 1185883 200194 89239320
Withdrawal syndrome 26.27 10.10 180 1188753 22344 89417170
Tendonitis 26.19 10.10 410 1188523 20962 89418552
Enterocolitis 26.18 10.10 62 1188871 10428 89429086
Product complaint 26.18 10.10 90 1188843 13410 89426104
Second primary malignancy 26.18 10.10 61 1188872 10317 89429197
Loss of employment 26.06 10.10 4 1188929 2983 89436531
Multiple sclerosis relapse 25.88 10.10 883 1188050 51422 89388092
Abortion incomplete 25.65 10.10 5 1188928 3135 89436379
Hepatitis B reactivation 25.62 10.10 10 1188923 3964 89435550
Grip strength decreased 25.58 10.10 1472 1187461 91104 89348410
Medical device removal 25.51 10.10 55 1188878 1278 89438236
Cyanosis 25.50 10.10 150 1188783 19305 89420209
Gait disturbance 25.31 10.10 3841 1185092 256655 89182859
Systemic candida 25.24 10.10 17 1188916 4942 89434572
Cardiospasm 25.15 10.10 7 1188926 3439 89436075
Pulmonary toxicity 25.09 10.10 73 1188860 11458 89428056
Hyperthermia 25.07 10.10 62 1188871 10273 89429241
Dental caries 25.02 10.10 244 1188689 11153 89428361
Sensory loss 24.97 10.10 137 1188796 17938 89421576
Ketoacidosis 24.89 10.10 22 1188911 5573 89433941
Accidental overdose 24.73 10.10 244 1188689 28029 89411485
Epstein-Barr virus associated lymphoproliferative disorder 24.62 10.10 3 1188930 2664 89436850
Condition aggravated 24.62 10.10 8439 1180494 587106 88852408
Parkinsonism 24.51 10.10 98 1188835 13967 89425547
Graft versus host disease in skin 24.34 10.10 10 1188923 3843 89435671
Multiple sclerosis 24.20 10.10 506 1188427 27334 89412180
Bradyphrenia 24.19 10.10 39 1188894 7573 89431941
Palmoplantar keratoderma 24.01 10.10 8 1188925 3499 89436015
Recalled product 24.01 10.10 55 1188878 1333 89438181
Removal of internal fixation 24.01 10.10 15 1188918 77 89439437
Febrile bone marrow aplasia 23.95 10.10 58 1188875 9680 89429834
Gastroenteritis viral 23.93 10.10 544 1188389 29811 89409703
Limb reduction defect 23.87 10.10 35 1188898 593 89438921
Bronchitis 23.83 10.10 2323 1186610 150604 89288910
Cholecystitis chronic 23.80 10.10 59 1188874 9767 89429747
Hypomagnesaemia 23.79 10.10 326 1188607 35262 89404252
Pregnancy with contraceptive device 23.67 10.10 19 1188914 5047 89434467
Heart rate decreased 23.46 10.10 891 1188042 52614 89386900
Transaminases increased 23.35 10.10 345 1188588 36847 89402667
Blood creatinine increased 23.32 10.10 1089 1187844 100297 89339217
C-reactive protein abnormal 23.26 10.10 1958 1186975 125471 89314043
Skin toxicity 23.22 10.10 33 1188900 6746 89432768
Multiple drug therapy 23.15 10.10 35 1188898 6974 89432540
Maternal exposure before pregnancy 23.14 10.10 237 1188696 10976 89428538
Blood pressure diastolic decreased 23.13 10.10 487 1188446 26339 89413175
Bezoar 23.09 10.10 4 1188929 2730 89436784
Nephropathy toxic 23.01 10.10 87 1188846 12601 89426913
Pneumothorax 22.94 10.10 152 1188781 19015 89420499
Joint destruction 22.90 10.10 271 1188662 13016 89426498
Flushing 22.72 10.10 939 1187994 87552 89351962
Oropharyngeal pain 22.65 10.10 1780 1187153 113407 89326107
Generalised tonic-clonic seizure 22.53 10.10 322 1188611 34581 89404933
Lumbar spinal stenosis 22.50 10.10 138 1188795 5459 89434055
Sexual dysfunction 22.47 10.10 18 1188915 4786 89434728
Neoplasm progression 22.28 10.10 430 1188503 44056 89395458
Intervertebral disc protrusion 22.26 10.10 490 1188443 26706 89412808
Atrioventricular block complete 22.16 10.10 61 1188872 9750 89429764
Dehydration 22.09 10.10 2223 1186710 192224 89247290
Night sweats 22.02 10.10 1969 1186964 126797 89312717
Haemorrhage intracranial 22.01 10.10 113 1188820 15049 89424465
Treatment noncompliance 21.82 10.10 514 1188419 51213 89388301
Lumbar vertebral fracture 21.76 10.10 170 1188763 7288 89432226
Muscle rigidity 21.72 10.10 105 1188828 14204 89425310
Haemorrhage 21.64 10.10 719 1188214 68650 89370864
Pneumatosis intestinalis 21.59 10.10 9 1188924 3428 89436086
Red blood cell count decreased 21.56 10.10 777 1188156 45574 89393940
Acute chest syndrome 21.55 10.10 47 1188886 1101 89438413
Localised infection 21.54 10.10 585 1188348 32977 89406537
Dyskinesia 21.54 10.10 343 1188590 36191 89403323
Product monitoring error 21.51 10.10 117 1188816 4427 89435087
Ileus paralytic 21.44 10.10 21 1188912 5064 89434450
Intraductal proliferative breast lesion 21.40 10.10 96 1188837 3357 89436157
Circulatory collapse 21.34 10.10 216 1188717 24688 89414826
Reversible cerebral vasoconstriction syndrome 21.24 10.10 14 1188919 4116 89435398
Paranoia 21.21 10.10 92 1188841 12816 89426698
Forced expiratory volume decreased 21.18 10.10 27 1188906 5781 89433733
Acute coronary syndrome 21.03 10.10 72 1188861 10741 89428773
Hypercalciuria 21.01 10.10 26 1188907 371 89439143
Periprosthetic fracture 20.95 10.10 32 1188901 563 89438951
Anxiety 20.94 10.10 3659 1185274 306113 89133401
Gastrooesophageal reflux disease 20.94 10.10 2491 1186442 163846 89275668
Left ventricular dysfunction 20.92 10.10 110 1188823 14559 89424955
Back pain 20.89 10.10 4584 1184349 312591 89126923
Acute lymphocytic leukaemia recurrent 20.87 10.10 5 1188928 2716 89436798
Asthma 20.77 10.10 2821 1186112 239339 89200175
Blood lactate dehydrogenase increased 20.56 10.10 229 1188704 25703 89413811
Product dose omission issue 20.42 10.10 4228 1184705 287459 89152055
Skin cancer 20.41 10.10 269 1188664 13250 89426264
Metabolic disorder 20.41 10.10 42 1188891 7428 89432086
Endodontic procedure 20.34 10.10 95 1188838 3380 89436134
Hallucination, visual 20.32 10.10 199 1188734 22893 89416621
Pseudomonal sepsis 20.27 10.10 16 1188917 4286 89435228
Exposure during pregnancy 20.17 10.10 3489 1185444 234921 89204593
Hypogammaglobulinaemia 20.14 10.10 72 1188861 10602 89428912
Spinal stenosis 20.13 10.10 331 1188602 17093 89422421
Rotator cuff syndrome 20.13 10.10 307 1188626 15612 89423902
Drug eruption 20.02 10.10 335 1188598 35072 89404442
Eosinophilia 19.94 10.10 259 1188674 28274 89411240
Dermatitis exfoliative 19.92 10.10 26 1188907 5510 89434004
Ileus 19.91 10.10 131 1188802 16415 89423099
Peripheral sensory neuropathy 19.80 10.10 59 1188874 9191 89430323
Device leakage 19.79 10.10 66 1188867 9925 89429589
Wheelchair user 19.79 10.10 172 1188761 7613 89431901
Rotator cuff repair 19.79 10.10 74 1188859 2380 89437134
Right ventricular failure 19.76 10.10 159 1188774 19046 89420468
Pulmonary alveolar haemorrhage 19.76 10.10 30 1188903 5968 89433546
Atrial tachycardia 19.69 10.10 30 1188903 5960 89433554
Toxic anterior segment syndrome 19.66 10.10 3 1188930 2247 89437267
Body mass index abnormal 19.63 10.10 35 1188898 704 89438810
Blood lactic acid increased 19.52 10.10 55 1188878 8723 89430791
Increased tendency to bruise 19.40 10.10 240 1188693 11650 89427864
Uterine perforation 19.38 10.10 44 1188889 7510 89432004
Disturbance in attention 19.35 10.10 470 1188463 46639 89392875
Spondylolisthesis 19.34 10.10 105 1188828 3970 89435544
Fear 19.31 10.10 133 1188800 16489 89423025
Developmental hip dysplasia 19.29 10.10 55 1188878 1530 89437984
Osteoporotic fracture 19.19 10.10 117 1188816 4619 89434895
Dyspepsia 19.14 10.10 2921 1186012 195239 89244275
Gastrointestinal toxicity 19.12 10.10 62 1188871 9405 89430109
Diabetes mellitus inadequate control 19.08 10.10 155 1188778 18529 89420985
Polyneuropathy 19.05 10.10 162 1188771 19179 89420335
Neuropathy peripheral 19.03 10.10 1542 1187391 135428 89304086
Dysphagia 18.99 10.10 1243 1187690 111035 89328479
Caesarean section 18.98 10.10 346 1188587 18231 89421283
Drug screen positive 18.96 10.10 13 1188920 3744 89435770
Activated partial thromboplastin time prolonged 18.94 10.10 47 1188886 7778 89431736
Meniscus injury 18.90 10.10 178 1188755 8059 89431455
Type I hypersensitivity 18.90 10.10 16 1188917 4139 89435375
Dermatitis acneiform 18.87 10.10 34 1188899 6320 89433194
Rash 18.81 10.10 11074 1177859 785026 88654488
Cross sensitivity reaction 18.74 10.10 7 1188926 2850 89436664
Muscle strain 18.70 10.10 202 1188731 9485 89430029
Drug abuser 18.66 10.10 6 1188927 2684 89436830
Hypoglycaemic coma 18.51 10.10 8 1188925 2982 89436532
Inflammation 18.49 10.10 2643 1186290 175949 89263565
Smear cervix abnormal 18.47 10.10 86 1188847 3056 89436458
Hallucination, auditory 18.47 10.10 128 1188805 15847 89423667
Anhedonia 18.46 10.10 82 1188851 11349 89428165
Arrhythmia 18.31 10.10 419 1188514 41913 89397601
Musculoskeletal pain 18.29 10.10 2539 1186394 168712 89270802
Talipes 18.26 10.10 56 1188877 1624 89437890
Sleep terror 18.18 10.10 19 1188914 4445 89435069
Folate deficiency 18.14 10.10 86 1188847 3079 89436435
Hyperammonaemia 18.04 10.10 36 1188897 6439 89433075
Hiatus hernia 18.01 10.10 448 1188485 24913 89414601
Agranulocytosis 17.93 10.10 337 1188596 34665 89404849
Skin papilloma 17.93 10.10 131 1188802 5499 89434015
Leukocytosis 17.92 10.10 292 1188641 30698 89408816
Acute pulmonary oedema 17.82 10.10 65 1188868 9515 89429999
Motor neurone disease 17.77 10.10 18 1188915 203 89439311
Hyperreflexia 17.71 10.10 38 1188895 6619 89432895
Acute graft versus host disease in intestine 17.70 10.10 3 1188930 2080 89437434
Anticholinergic syndrome 17.53 10.10 7 1188926 2736 89436778
Aspiration 17.53 10.10 127 1188806 15566 89423948
Atrial septal defect 17.45 10.10 175 1188758 8059 89431455
Nephritic syndrome 17.41 10.10 24 1188909 383 89439131
Acute myeloid leukaemia recurrent 17.40 10.10 3 1188930 2054 89437460
Dermatitis atopic 17.38 10.10 417 1188516 23055 89416459
Mouth ulceration 17.37 10.10 665 1188268 39309 89400205
Breast cancer female 17.34 10.10 119 1188814 14767 89424747
Injection site bruising 17.32 10.10 846 1188087 51461 89388053
Pulmonary congestion 17.30 10.10 167 1188766 19266 89420248
Central nervous system lupus 17.28 10.10 48 1188885 1315 89438199
Parathyroid tumour benign 17.21 10.10 38 1188895 898 89438616
Immunisation 17.10 10.10 4 1188929 2209 89437305
Eosinophil count increased 17.07 10.10 101 1188832 12980 89426534
Full blood count decreased 16.98 10.10 510 1188423 29179 89410335
Heart rate increased 16.94 10.10 1263 1187670 111639 89327875
Deep vein thrombosis 16.93 10.10 1006 1187927 90614 89348900
Hepatic necrosis 16.92 10.10 37 1188896 6401 89433113
Joint injury 16.81 10.10 554 1188379 32110 89407404
Breast cancer stage I 16.81 10.10 67 1188866 9557 89429957
Speech disorder 16.80 10.10 462 1188471 45123 89394391
Acidosis 16.80 10.10 98 1188835 12638 89426876
Sinus rhythm 16.78 10.10 48 1188885 1338 89438176
Vasoplegia syndrome 16.68 10.10 8 1188925 2806 89436708
Hypersensitivity 16.59 10.10 6414 1182519 448263 88991251
Pulse absent 16.58 10.10 34 1188899 6021 89433493
International normalised ratio fluctuation 16.57 10.10 10 1188923 3083 89436431
Hyperparathyroidism 16.53 10.10 87 1188846 3250 89436264
Tonsillectomy 16.49 10.10 40 1188893 1007 89438507
Neutropenic colitis 16.46 10.10 18 1188915 4125 89435389
Bone metabolism disorder 16.44 10.10 24 1188909 405 89439109
Latent tuberculosis 16.43 10.10 80 1188853 2896 89436618
Muscle twitching 16.43 10.10 221 1188712 23981 89415533
Intracranial pressure increased 16.41 10.10 41 1188892 6770 89432744
Paralysis 16.41 10.10 86 1188847 11392 89428122
Body temperature decreased 16.41 10.10 419 1188514 23397 89416117
Motor dysfunction 16.39 10.10 167 1188766 19063 89420451
Surgery 16.36 10.10 733 1188200 44154 89395360
Postoperative renal failure 16.36 10.10 14 1188919 125 89439389
Swelling face 16.36 10.10 886 1188047 80466 89359048
Device malfunction 16.34 10.10 186 1188747 20791 89418723
Pancreatitis acute 16.21 10.10 310 1188623 31805 89407709
Capillary leak syndrome 16.20 10.10 8 1188925 2759 89436755
Hyperprolactinaemia 16.20 10.10 29 1188904 5404 89434110
Hypoalbuminaemia 16.18 10.10 132 1188801 15765 89423749
Thyroid mass 16.15 10.10 123 1188810 5232 89434282
Sneezing 16.11 10.10 285 1188648 29584 89409930
Bone graft 16.10 10.10 39 1188894 981 89438533
Ligament rupture 16.09 10.10 94 1188839 3654 89435860
Hypervitaminosis D 15.98 10.10 12 1188921 87 89439427
Cardiac tamponade 15.96 10.10 31 1188902 5601 89433913
Blood parathyroid hormone increased 15.94 10.10 88 1188845 3349 89436165
Gait spastic 15.92 10.10 20 1188913 290 89439224
Linear IgA disease 15.90 10.10 5 1188928 2269 89437245
Drug effective for unapproved indication 15.90 10.10 52 1188881 7866 89431648
Upper limb fracture 15.87 10.10 383 1188550 21195 89418319
Nervous system disorder 15.84 10.10 194 1188739 21399 89418115
Vitamin D increased 15.83 10.10 37 1188896 909 89438605
Jaw disorder 15.83 10.10 126 1188807 5433 89434081
Cold type haemolytic anaemia 15.82 10.10 20 1188913 292 89439222
Pruritus genital 15.80 10.10 22 1188911 4536 89434978
Tibia fracture 15.74 10.10 135 1188798 5952 89433562
Cystic fibrosis 15.74 10.10 97 1188836 3844 89435670
Pelvic fracture 15.74 10.10 284 1188649 14935 89424579
Nocardiosis 15.71 10.10 7 1188926 2563 89436951
Nodule 15.69 10.10 460 1188473 26226 89413288
Dysphoria 15.66 10.10 36 1188897 6118 89433396
Product administered to patient of inappropriate age 15.59 10.10 23 1188910 4630 89434884
Amenorrhoea 15.57 10.10 90 1188843 11632 89427882
Post procedural hypothyroidism 15.51 10.10 22 1188911 361 89439153
Fibula fracture 15.51 10.10 102 1188831 4135 89435379
Acute myocardial infarction 15.47 10.10 344 1188589 34546 89404968
Constipation 15.45 10.10 3347 1185586 277048 89162466
Brain injury 15.41 10.10 51 1188882 7687 89431827
Cyst 15.39 10.10 304 1188629 16257 89423257
Mobility decreased 15.38 10.10 3612 1185321 247122 89192392
Hallucinations, mixed 15.35 10.10 34 1188899 5855 89433659
Joint stiffness 15.34 10.10 1206 1187727 76836 89362678
Pseudomonas infection 15.33 10.10 123 1188810 14742 89424772
Complication associated with device 15.32 10.10 172 1188761 19277 89420237
Lumbar radiculopathy 15.29 10.10 71 1188862 2520 89436994
Toothache 15.28 10.10 391 1188542 21839 89417675
Foetal death 15.27 10.10 186 1188747 20537 89418977
Accidental death 15.25 10.10 4 1188929 2044 89437470
Oral infection 15.21 10.10 120 1188813 5160 89434354
Isosthenuria 15.20 10.10 13 1188920 116 89439398
Diverticulum intestinal 15.12 10.10 185 1188748 8957 89430557
Skin exfoliation 15.11 10.10 732 1188201 67181 89372333
Ventricular septal defect 15.09 10.10 122 1188811 5285 89434229
Pulmonary arterial hypertension 15.06 10.10 247 1188686 25940 89413574
Palpitations 14.99 10.10 1567 1187366 135161 89304353
Humerus fracture 14.90 10.10 195 1188738 9590 89429924
Subacute cutaneous lupus erythematosus 14.86 10.10 15 1188918 3567 89435947
Foetal exposure during pregnancy 14.85 10.10 698 1188235 42277 89397237
Hypercholesterolaemia 14.76 10.10 1526 1187407 99366 89340148
Injection site swelling 14.76 10.10 942 1187991 58897 89380617
Disturbance in social behaviour 14.73 10.10 20 1188913 4168 89435346
Respiratory tract congestion 14.64 10.10 262 1188671 27148 89412366
Limb deformity 14.62 10.10 99 1188834 4053 89435461
Colitis 14.58 10.10 759 1188174 69183 89370331
Gingival disorder 14.56 10.10 96 1188837 3895 89435619
Pulmonary haemorrhage 14.49 10.10 55 1188878 7958 89431556
Facial paralysis 14.47 10.10 132 1188801 15402 89424112
Metastases to skin 14.45 10.10 5 1188928 2135 89437379
Visual acuity reduced 14.40 10.10 218 1188715 23192 89416322
Edentulous 14.36 10.10 17 1188916 231 89439283
Melaena 14.33 10.10 347 1188586 34450 89405064
Renal tubular necrosis 14.30 10.10 122 1188811 14433 89425081
Hyperparathyroidism secondary 14.26 10.10 54 1188879 1747 89437767
JC polyomavirus test positive 14.25 10.10 54 1188879 1748 89437766
Skin haemorrhage 14.24 10.10 196 1188737 21184 89418330
Squamous cell carcinoma of skin 14.23 10.10 155 1188778 7294 89432220
Muscle spasms 14.20 10.10 3615 1185318 248268 89191246
Limb discomfort 14.20 10.10 623 1188310 37437 89402077
Calcium deficiency 14.09 10.10 44 1188889 1289 89438225
Unintended pregnancy 14.09 10.10 52 1188881 7585 89431929
Hepatitis cholestatic 14.08 10.10 61 1188872 8500 89431014
Retrognathia 14.08 10.10 26 1188907 538 89438976
Infection reactivation 14.05 10.10 4 1188929 1936 89437578
Knee operation 14.03 10.10 146 1188787 6790 89432724
Hypothalamo-pituitary disorder 13.98 10.10 6 1188927 2246 89437268
Endophthalmitis 13.97 10.10 25 1188908 4660 89434854
Pneumonitis 13.97 10.10 457 1188476 43713 89395801
Inadequate analgesia 13.96 10.10 13 1188920 3211 89436303
Immunosuppressant drug level increased 13.94 10.10 25 1188908 4655 89434859
Device related infection 13.92 10.10 246 1188687 25540 89413974
Catheter site pain 13.90 10.10 33 1188900 5546 89433968
Spinal compression fracture 13.90 10.10 278 1188655 14900 89424614
Osteomalacia 13.89 10.10 34 1188899 861 89438653
Hyperaesthesia teeth 13.89 10.10 63 1188870 2214 89437300
Nightmare 13.82 10.10 201 1188732 21524 89417990
Amylase increased 13.82 10.10 47 1188886 7025 89432489
Libido increased 13.78 10.10 3 1188930 1741 89437773
Irritability 13.78 10.10 359 1188574 35303 89404211
Atrioventricular block 13.78 10.10 64 1188869 8751 89430763
Tenosynovitis stenosans 13.77 10.10 94 1188839 3859 89435655
Bradypnoea 13.76 10.10 25 1188908 4633 89434881
Sinus bradycardia 13.72 10.10 149 1188784 16803 89422711
Clostridium difficile colitis 13.72 10.10 257 1188676 26449 89413065
Invasive ductal breast carcinoma 13.72 10.10 160 1188773 7658 89431856
Potentiating drug interaction 13.71 10.10 34 1188899 5628 89433886
Generalised oedema 13.67 10.10 172 1188761 18881 89420633
Pericardial effusion 13.65 10.10 373 1188560 36460 89403054
Ovarian hyperstimulation syndrome 13.58 10.10 36 1188897 5826 89433688
Heparin-induced thrombocytopenia 13.58 10.10 31 1188902 5281 89434233
Live birth 13.57 10.10 1210 1187723 77897 89361617
Sciatica 13.52 10.10 1524 1187409 99858 89339656
Product substitution issue 13.51 10.10 161 1188772 17847 89421667
Immune reconstitution inflammatory syndrome 13.47 10.10 47 1188886 6972 89432542
Myocardial ischaemia 13.47 10.10 116 1188817 13698 89425816
Disorganised speech 13.44 10.10 4 1188929 1881 89437633
Pulmonary hypertension 13.44 10.10 440 1188493 42083 89397431
Aneurysmal bone cyst 13.39 10.10 4 1188929 0 89439514
Tooth infection 13.35 10.10 353 1188580 19817 89419697
Enthesopathy 13.33 10.10 185 1188748 9219 89430295
Progressive bulbar palsy 13.32 10.10 9 1188924 54 89439460
Periodontal disease 13.29 10.10 51 1188882 1661 89437853
Drug-induced liver injury 13.28 10.10 1012 1187921 89306 89350208
Nephrolithiasis 13.28 10.10 779 1188154 48306 89391208
Synovial disorder 13.25 10.10 78 1188855 3040 89436474
Therapeutic product effect incomplete 13.23 10.10 2289 1186644 191607 89247907
Anaphylactoid reaction 13.19 10.10 24 1188909 4444 89435070
Abscess oral 13.17 10.10 48 1188885 1524 89437990
Diabetes mellitus 13.14 10.10 706 1188227 64169 89375345
Enterococcal infection 13.11 10.10 77 1188856 9914 89429600
Weight decreased 13.11 10.10 5349 1183584 374561 89064953
Blood pressure inadequately controlled 13.11 10.10 40 1188893 6184 89433330
Ankle fracture 13.06 10.10 355 1188578 20015 89419499
Exostosis 13.02 10.10 836 1188097 52298 89387216
Groin pain 13.02 10.10 229 1188704 11984 89427530
Hungry bone syndrome 13.01 10.10 13 1188920 144 89439370
Catheter site erythema 12.97 10.10 28 1188905 4866 89434648
Congestive cardiomyopathy 12.97 10.10 51 1188882 7303 89432211
Acrochordon 12.93 10.10 46 1188887 1443 89438071
Hyperlipidaemia 12.93 10.10 393 1188540 22523 89416991
Immune effector cell-associated neurotoxicity syndrome 12.93 10.10 36 1188897 5732 89433782
Device loosening 12.89 10.10 33 1188900 860 89438654
Ankylosing spondylitis 12.86 10.10 243 1188690 12890 89426624
Squamous cell carcinoma 12.85 10.10 195 1188738 9906 89429608
Cardiac dysfunction 12.83 10.10 17 1188916 3580 89435934
Eye infection 12.69 10.10 260 1188673 13994 89425520
White matter lesion 12.68 10.10 66 1188867 2455 89437059
Cystitis haemorrhagic 12.66 10.10 34 1188899 5479 89434035
Complication of device removal 12.61 10.10 41 1188892 6214 89433300
Neutropenic infection 12.61 10.10 4 1188929 1805 89437709
Coronary artery disease 12.59 10.10 340 1188593 33283 89406231
Metastasis 12.53 10.10 40 1188893 6097 89433417
Temporomandibular joint syndrome 12.53 10.10 93 1188840 3924 89435590
Neovascularisation 12.49 10.10 3 1188930 1627 89437887
Rash morbilliform 12.47 10.10 21 1188912 4008 89435506
Product preparation error 12.47 10.10 81 1188852 10180 89429334
Mitral valve prolapse 12.46 10.10 67 1188866 2524 89436990
Limb hypoplasia congenital 12.44 10.10 15 1188918 208 89439306
Brain death 12.41 10.10 21 1188912 4000 89435514
Hyperlactacidaemia 12.40 10.10 22 1188911 4114 89435400
Complication of device insertion 12.37 10.10 83 1188850 10353 89429161
Ingrowing nail 12.37 10.10 72 1188861 2795 89436719
Methaemoglobinaemia 12.36 10.10 21 1188912 3994 89435520
Pancreatic neuroendocrine tumour 12.29 10.10 26 1188907 596 89438918
Hypophagia 12.29 10.10 368 1188565 35569 89403945
Dry mouth 12.29 10.10 2662 1186271 181397 89258117
Breast disorder 12.27 10.10 70 1188863 2697 89436817
Plantar fasciitis 12.24 10.10 97 1188836 4177 89435337
Pharyngitis streptococcal 12.21 10.10 235 1188698 12507 89427007
Biopsy breast 12.21 10.10 17 1188916 274 89439240
Liver injury 12.19 10.10 2475 1186458 168092 89271422
Nystagmus 12.19 10.10 51 1188882 7176 89432338
Cardiac failure acute 12.16 10.10 99 1188834 11830 89427684
Wound infection 12.16 10.10 1584 1187349 104818 89334696
Galactorrhoea 12.16 10.10 27 1188906 4645 89434869
Large intestine perforation 12.14 10.10 76 1188857 9636 89429878
Maternal drugs affecting foetus 12.13 10.10 112 1188821 5043 89434471
Musculoskeletal discomfort 12.12 10.10 361 1188572 20630 89418884
Hypoproteinaemia 12.10 10.10 14 1188919 3128 89436386
Candida infection 12.08 10.10 347 1188586 33710 89405804
Abdominal pain 12.08 10.10 4842 1184091 390879 89048635
Type IIa hyperlipidaemia 12.06 10.10 18 1188915 310 89439204
Ventricular dysfunction 11.97 10.10 19 1188914 3712 89435802
Adenoidal disorder 11.96 10.10 13 1188920 160 89439354
Bacteraemia 11.96 10.10 213 1188720 22087 89417427
Congenital arterial malformation 11.94 10.10 18 1188915 313 89439201
Essential hypertension 11.87 10.10 131 1188802 6184 89433330
Product prescribing issue 11.85 10.10 59 1188874 7920 89431594
Deafness transitory 11.82 10.10 6 1188927 2037 89437477
Hepatitis fulminant 11.81 10.10 21 1188912 3924 89435590
Malignant mediastinal neoplasm 11.81 10.10 43 1188890 1365 89438149
Enzyme level decreased 11.77 10.10 6 1188927 19 89439495
Skin laceration 11.76 10.10 435 1188498 25600 89413914
Scapula fracture 11.75 10.10 22 1188911 460 89439054
Acute respiratory failure 11.75 10.10 452 1188481 42466 89397048
Pulmonary fibrosis 11.74 10.10 1596 1187337 105907 89333607
Venoocclusive disease 11.73 10.10 9 1188924 2446 89437068
Cleft palate 11.73 10.10 41 1188892 1275 89438239
Premature rupture of membranes 11.72 10.10 118 1188815 5440 89434074
Pneumonia aspiration 11.69 10.10 429 1188504 40511 89399003
Scleritis 11.68 10.10 112 1188821 5096 89434418
Dry eye 11.68 10.10 897 1188036 57034 89382480
Appendicectomy 11.64 10.10 84 1188849 3512 89436002
Viral mutation identified 11.64 10.10 6 1188927 2019 89437495
Long QT syndrome 11.63 10.10 22 1188911 4015 89435499
Ligament sprain 11.62 10.10 262 1188671 14337 89425177
Neck mass 11.61 10.10 89 1188844 3793 89435721
Prescribed underdose 11.60 10.10 1139 1187794 73880 89365634
Premature labour 11.59 10.10 243 1188690 13133 89426381
Post procedural infection 11.57 10.10 207 1188726 10867 89428647
Hyperammonaemic encephalopathy 11.55 10.10 11 1188922 2688 89436826
Bone fissure 11.53 10.10 23 1188910 505 89439009
Ventricular hypokinesia 11.48 10.10 34 1188899 5307 89434207
Patellofemoral pain syndrome 11.44 10.10 29 1188904 751 89438763
Pneumocystis jirovecii pneumonia 11.42 10.10 207 1188726 21409 89418105
Immune-mediated myositis 11.41 10.10 9 1188924 2412 89437102
Fibroadenoma of breast 11.41 10.10 31 1188902 838 89438676
Intestinal ischaemia 11.37 10.10 69 1188864 8814 89430700
Enostosis 11.37 10.10 5 1188928 10 89439504
Appendix disorder 11.37 10.10 45 1188888 1487 89438027
Laryngeal oedema 11.33 10.10 49 1188884 6832 89432682
Pupillary reflex impaired 11.33 10.10 10 1188923 2535 89436979
Vertebral wedging 11.33 10.10 6 1188927 21 89439493
Hostility 11.29 10.10 8 1188925 2265 89437249
Varicella zoster virus infection 11.29 10.10 21 1188912 3856 89435658
Gene mutation 11.25 10.10 7 1188926 2123 89437391
Obesity 11.23 10.10 1564 1187369 103943 89335571
Ventricular arrhythmia 11.22 10.10 25 1188908 4296 89435218
Dental prosthesis user 11.22 10.10 8 1188925 53 89439461
Injection site rash 11.19 10.10 405 1188528 23768 89415746
Apraxia 11.19 10.10 8 1188925 2254 89437260
Endovenous ablation 11.19 10.10 4 1188929 3 89439511
Immune-mediated enterocolitis 11.18 10.10 29 1188904 4728 89434786
Haemorrhage subcutaneous 11.17 10.10 17 1188916 3379 89436135
Breast feeding 11.10 10.10 31 1188902 852 89438662
Viraemia 11.10 10.10 4 1188929 1665 89437849
Steroid therapy 11.08 10.10 12 1188921 147 89439367
Loose body in joint 11.07 10.10 42 1188891 1360 89438154
Hormone replacement therapy 11.06 10.10 5 1188928 11 89439503
Periodontal operation 11.05 10.10 7 1188926 37 89439477
Bladder operation 11.03 10.10 34 1188899 989 89438525
Cleft lip and palate 10.98 10.10 28 1188905 728 89438786
Antinuclear antibody negative 10.96 10.10 16 1188917 270 89439244
Gallbladder operation 10.94 10.10 68 1188865 2703 89436811
Blood parathyroid hormone abnormal 10.90 10.10 15 1188918 239 89439275
Congenital oral malformation 10.89 10.10 14 1188919 208 89439306
Paronychia 10.89 10.10 61 1188872 7945 89431569
Cartilage injury 10.86 10.10 56 1188877 2075 89437439
Rosacea 10.86 10.10 121 1188812 5726 89433788
Polyhydramnios 10.83 10.10 63 1188870 2445 89437069
Hypervolaemia 10.82 10.10 337 1188596 32420 89407094
Foetal anticonvulsant syndrome 10.81 10.10 26 1188907 651 89438863
Fungaemia 10.80 10.10 17 1188916 3333 89436181
Retinal haemorrhage 10.80 10.10 39 1188894 5725 89433789
Type IV hypersensitivity reaction 10.79 10.10 22 1188911 3904 89435610
Cutaneous vasculitis 10.79 10.10 53 1188880 7140 89432374
Milk-alkali syndrome 10.78 10.10 39 1188894 1234 89438280
Chronic kidney disease 10.78 10.10 543 1188390 49648 89389866
Off label use 10.77 10.10 13909 1175024 1088343 88351171
Colitis microscopic 10.75 10.10 94 1188839 11065 89428449
Device deployment issue 10.74 10.10 31 1188902 4878 89434636
Bacterial infection 10.73 10.10 230 1188703 23214 89416300
Blood pressure diastolic increased 10.71 10.10 233 1188700 12673 89426841
Cholelithiasis 10.71 10.10 571 1188362 51935 89387579
Sarcoidosis 10.69 10.10 89 1188844 10584 89428930
Laryngospasm 10.67 10.10 17 1188916 3316 89436198
Tonsillitis 10.66 10.10 139 1188794 6830 89432684
Staphylococcal bacteraemia 10.66 10.10 56 1188877 7413 89432101
Wrong product administered 10.64 10.10 58 1188875 7607 89431907
Kyphosis 10.64 10.10 70 1188863 2838 89436676
Traumatic arthritis 10.62 10.10 7 1188926 40 89439474
Anxiety disorder 10.62 10.10 105 1188828 4817 89434697
Clear cell renal cell carcinoma 10.61 10.10 45 1188888 1535 89437979
Colitis ischaemic 10.61 10.10 107 1188826 12239 89427275
Tuberculosis 10.56 10.10 227 1188706 12322 89427192
Product administration interrupted 10.52 10.10 226 1188707 12266 89427248
Pyelitis 10.49 10.10 15 1188918 248 89439266
Bone contusion 10.49 10.10 36 1188897 1109 89438405
Metastases to pleura 10.41 10.10 7 1188926 2037 89437477
Staphylococcal infection 10.41 10.10 524 1188409 47915 89391599
Vision blurred 10.40 10.10 1277 1187656 109016 89330498
Corneal oedema 10.39 10.10 6 1188927 1895 89437619
Ulna fracture 10.36 10.10 39 1188894 1258 89438256
Tubulointerstitial nephritis 10.36 10.10 253 1188680 25090 89414424
Pseudomembranous colitis 10.36 10.10 22 1188911 3846 89435668
Breast cancer stage IV 10.36 10.10 7 1188926 2031 89437483
Blood iron increased 10.35 10.10 52 1188881 1907 89437607
Brain herniation 10.34 10.10 25 1188908 4175 89435339
Road traffic accident 10.33 10.10 1586 1187347 106040 89333474
Blood pH decreased 10.29 10.10 11 1188922 2547 89436967
Joint range of motion decreased 10.28 10.10 1974 1186959 133669 89305845
Learning disorder 10.24 10.10 30 1188903 848 89438666
Neutrophilia 10.23 10.10 40 1188893 5738 89433776
Pallor 10.21 10.10 356 1188577 33809 89405705
Closed fracture manipulation 10.21 10.10 6 1188927 27 89439487
Neck pain 10.21 10.10 1673 1187260 112290 89327224
Cytomegalovirus chorioretinitis 10.19 10.10 10 1188923 2409 89437105
Placental disorder 10.14 10.10 45 1188888 1566 89437948
Loss of personal independence in daily activities 10.14 10.10 1979 1186954 134126 89305388
Knee deformity 10.12 10.10 44 1188889 1518 89437996
Renal mass 10.11 10.10 62 1188871 2453 89437061

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 671.73 10.98 664 389307 228472 42002892
Drug abuse 500.59 10.98 167 389804 104604 42126760
Completed suicide 491.12 10.98 137 389834 96328 42135036
Rheumatoid arthritis 369.49 10.98 1036 388935 41404 42189960
Drug interaction 266.05 10.98 1398 388573 265601 41965763
Intentional overdose 219.18 10.98 98 389873 51358 42180006
Drug ineffective 202.34 10.98 4317 385654 625880 41605484
Hepatic function abnormal 197.49 10.98 113 389858 51454 42179910
Arthralgia 194.72 10.98 2793 387178 202445 42028919
Psoriatic arthropathy 190.89 10.98 582 389389 24385 42206979
Fatigue 186.94 10.98 5260 384711 430381 41800983
Foetal exposure during pregnancy 160.06 10.98 855 389116 46456 42184908
Multiple organ dysfunction syndrome 145.63 10.98 431 389540 96604 42134760
Drug resistance 144.63 10.98 66 389905 34182 42197182
Psoriasis 127.25 10.98 821 389150 47783 42183581
Coma 121.07 10.98 189 389782 53365 42177999
Myelosuppression 119.67 10.98 116 389855 40345 42191019
Death 119.13 10.98 3343 386628 467842 41763522
Fall 118.20 10.98 2894 387077 231626 41999738
Disease progression 105.46 10.98 825 389146 142831 42088533
Overdose 102.97 10.98 554 389417 104710 42126654
Rhabdomyolysis 100.85 10.98 370 389601 77649 42153715
Sickle cell anaemia with crisis 100.36 10.98 169 389802 4721 42226643
Acute kidney injury 96.08 10.98 2593 387378 364744 41866620
Off label use 95.44 10.98 4824 385147 633511 41597853
Febrile neutropenia 93.70 10.98 1168 388803 184535 42046829
Drug ineffective for unapproved indication 92.38 10.98 176 389795 45987 42185377
Suicide attempt 89.45 10.98 179 389792 45921 42185443
Drug reaction with eosinophilia and systemic symptoms 89.03 10.98 155 389816 41920 42189444
Product use in unapproved indication 87.58 10.98 1175 388796 183281 42048083
Infective pulmonary exacerbation of cystic fibrosis 86.64 10.98 209 389762 7609 42223755
Dysmorphism 85.18 10.98 127 389844 3189 42228175
Weight decreased 84.08 10.98 2494 387477 205454 42025910
Cytomegalovirus infection 83 10.98 104 389867 32202 42199162
Nasopharyngitis 82.61 10.98 1151 388820 82845 42148519
Serotonin syndrome 82.52 10.98 69 389902 25776 42205588
Sedation 81.59 10.98 95 389876 30380 42200984
Cardiac arrest 81.05 10.98 626 389345 108694 42122670
Toxic epidermal necrolysis 79.91 10.98 76 389895 26674 42204690
Pain 79.49 10.98 2861 387110 241987 41989377
Product dose omission issue 74.11 10.98 1893 388078 152472 42078892
Respiratory arrest 73.55 10.98 91 389880 28333 42203031
Altered state of consciousness 72.27 10.98 97 389874 29162 42202202
Blood pressure fluctuation 71.31 10.98 456 389515 26452 42204912
Peripheral swelling 69.59 10.98 1187 388784 89083 42142281
Vitamin D deficiency 69.16 10.98 196 389775 7877 42223487
Pain in extremity 67.70 10.98 1831 388140 148773 42082591
Joint swelling 67.23 10.98 933 389038 67089 42164275
Renal failure 66.22 10.98 921 389050 142805 42088559
Disseminated intravascular coagulation 65.61 10.98 78 389893 24716 42206648
Pathogen resistance 64.65 10.98 13 389958 11437 42219927
Drug use disorder 64.39 10.98 9 389962 10324 42221040
Multiple sclerosis relapse 64.27 10.98 280 389691 13984 42217380
Depressed level of consciousness 63.63 10.98 225 389746 47745 42183619
Shock 62.78 10.98 106 389865 29015 42202349
Arthritis 61.04 10.98 621 389350 41444 42189920
Speech disorder developmental 59.39 10.98 88 389883 2197 42229167
Musculoskeletal stiffness 58.99 10.98 797 389174 56968 42174396
Hepatic failure 58.74 10.98 167 389804 37933 42193431
Vitamin D decreased 58.08 10.98 128 389843 4387 42226977
Poisoning 58.01 10.98 31 389940 14668 42216696
Colitis ulcerative 57.16 10.98 423 389548 25752 42205612
Cardio-respiratory arrest 57.08 10.98 309 389662 58327 42173037
Angioedema 56.49 10.98 199 389772 42278 42189086
Therapy partial responder 56.24 10.98 60 389911 19961 42211403
Respiratory failure 55.87 10.98 830 389141 127302 42104062
Osteoarthritis 55.36 10.98 398 389573 24007 42207357
Basal cell carcinoma 55.24 10.98 377 389594 22356 42209008
Neuroleptic malignant syndrome 54.24 10.98 70 389901 21402 42209962
Synovitis 53.07 10.98 282 389689 15285 42216079
Ventricular fibrillation 52.60 10.98 124 389847 29999 42201365
Intentional product misuse 52.42 10.98 341 389630 61559 42169805
Acute hepatic failure 51.59 10.98 48 389923 17025 42214339
Small for dates baby 51.30 10.98 134 389837 5129 42226235
Malignant neoplasm progression 50.85 10.98 692 389279 107708 42123656
Acute graft versus host disease 49.25 10.98 8 389963 8207 42223157
Neurotoxicity 49.24 10.98 88 389883 23563 42207801
Intervertebral disc degeneration 48.35 10.98 163 389808 7204 42224160
Cough 48.26 10.98 2041 387930 176062 42055302
Post transplant lymphoproliferative disorder 48.18 10.98 12 389959 9108 42222256
Anaphylactic shock 47.62 10.98 89 389882 23428 42207936
Aspergillus infection 47.29 10.98 45 389926 15792 42215572
Drug withdrawal syndrome 46.85 10.98 78 389893 21471 42209893
Interstitial lung disease 46.79 10.98 475 389496 77987 42153377
Cardiogenic shock 46.71 10.98 168 389803 35472 42195892
Substance abuse 46.50 10.98 12 389959 8893 42222471
Enthesopathy 46.12 10.98 122 389849 4706 42226658
Lymphoid tissue hypoplasia 45.84 10.98 48 389923 830 42230534
Autism spectrum disorder 45.78 10.98 91 389880 2897 42228467
Maternal exposure during pregnancy 45.45 10.98 154 389817 6824 42224540
Juvenile idiopathic arthritis 44.87 10.98 84 389887 2555 42228809
Thymus hypoplasia 44.78 10.98 47 389924 815 42230549
Pulmonary fibrosis 44.68 10.98 406 389565 26275 42205089
Septic shock 44.52 10.98 581 389390 91091 42140273
Electrocardiogram QT prolonged 44.31 10.98 257 389714 47688 42183676
Intentional dose omission 44.06 10.98 181 389790 8805 42222559
Sinusitis 44.05 10.98 642 389329 46650 42184714
Acute respiratory distress syndrome 43.51 10.98 136 389835 29972 42201392
Mucormycosis 42.72 10.98 7 389964 7136 42224228
Nodule 42.69 10.98 227 389744 12307 42219057
Renal impairment 42.37 10.98 731 389240 109497 42121867
Tenosynovitis 42.20 10.98 116 389855 4579 42226785
Cytomegalovirus infection reactivation 42.06 10.98 25 389946 11153 42220211
Influenza 41.70 10.98 800 389171 61375 42169989
Cardiac failure 41.60 10.98 707 389264 106149 42125215
Anal fissure 40.85 10.98 123 389848 5116 42226248
Acute graft versus host disease in skin 40.74 10.98 9 389962 7415 42223949
Haematotoxicity 40.73 10.98 25 389946 10960 42220404
Lactic acidosis 40.56 10.98 245 389726 45016 42186348
Venoocclusive liver disease 40.26 10.98 22 389949 10280 42221084
Cystitis haemorrhagic 39.99 10.98 9 389962 7320 42224044
Suspected suicide 39.58 10.98 5 389966 6194 42225170
Red blood cell count decreased 39.19 10.98 465 389506 32250 42199114
Poisoning deliberate 39.08 10.98 22 389949 10112 42221252
Posterior reversible encephalopathy syndrome 38.79 10.98 36 389935 12785 42218579
Blood pressure systolic abnormal 38.68 10.98 125 389846 5403 42225961
Ventricular tachycardia 38.32 10.98 144 389827 30016 42201348
Foetal anticonvulsant syndrome 38.24 10.98 51 389920 1151 42230213
Eosinophilia 38.05 10.98 163 389808 32736 42198628
Hypotension 37.23 10.98 1952 388019 255679 41975685
Bronchopulmonary aspergillosis 37.20 10.98 76 389895 19353 42212011
Poor venous access 37.09 10.98 148 389823 7104 42224260
Appendicolith 37.04 10.98 41 389930 13415 42217949
Joint effusion 36.54 10.98 128 389843 5769 42225595
Wound 36.45 10.98 275 389696 16842 42214522
Blood pressure diastolic abnormal 36.24 10.98 131 389840 5997 42225367
General physical health deterioration 36.08 10.98 1711 388260 149535 42081829
Trisomy 18 36.01 10.98 42 389929 823 42230541
Intentional self-injury 35.94 10.98 52 389919 15150 42216214
Agitation 35.65 10.98 396 389575 63918 42167446
Heart rate decreased 35.64 10.98 500 389471 36032 42195332
Suicidal ideation 35.56 10.98 276 389695 47885 42183479
Cardiotoxicity 35.29 10.98 12 389959 7433 42223931
Relapsing-remitting multiple sclerosis 35.21 10.98 55 389916 1440 42229924
Cryptorchism 35.07 10.98 65 389906 1962 42229402
Blood pressure systolic increased 35.05 10.98 401 389570 27567 42203797
Hypoglycaemia neonatal 34.78 10.98 67 389904 2083 42229281
Multiple-drug resistance 34.36 10.98 12 389959 7310 42224054
Neonatal respiratory distress syndrome 34.29 10.98 105 389866 4408 42226956
Palmar-plantar erythrodysaesthesia syndrome 34.15 10.98 87 389884 20495 42210869
BK virus infection 33.97 10.98 19 389952 8765 42222599
COVID-19 33.96 10.98 1340 388631 114608 42116756
Haematochezia 33.93 10.98 736 389235 57700 42173664
Multiple sclerosis 33.36 10.98 148 389823 7450 42223914
Cellulitis 33.35 10.98 768 389203 60817 42170547
Graft versus host disease in gastrointestinal tract 33.20 10.98 4 389967 5139 42226225
Somnolence 33.19 10.98 1010 388961 140095 42091269
Osteoporosis 33.18 10.98 242 389729 14664 42216700
Arthropathy 32.99 10.98 415 389556 29182 42202182
Bone giant cell tumour 32.87 10.98 13 389958 30 42231334
Loss of personal independence in daily activities 32.73 10.98 639 389332 49177 42182187
Therapy non-responder 32.65 10.98 321 389650 53038 42178326
Thrombocytopenia 32.56 10.98 1416 388555 188863 42042501
Immune reconstitution inflammatory syndrome 32.48 10.98 27 389944 10116 42221248
Stevens-Johnson syndrome 32.17 10.98 100 389871 22078 42209286
Back pain 32.15 10.98 1596 388375 140180 42091184
Rash maculo-papular 32.05 10.98 206 389765 37297 42194067
Miosis 31.78 10.98 46 389925 13400 42217964
Low birth weight baby 31.69 10.98 177 389794 9778 42221586
Memory impairment 31.59 10.98 640 389331 49582 42181782
Gait disturbance 31.43 10.98 1144 388827 96856 42134508
Abdominal discomfort 31.26 10.98 906 389065 74349 42157015
Balance disorder 31.25 10.98 611 389360 47034 42184330
Blood iron decreased 30.77 10.98 127 389844 6191 42225173
Thrombotic microangiopathy 30.77 10.98 55 389916 14727 42216637
Gait spastic 30.67 10.98 50 389921 1359 42230005
Grip strength decreased 30.62 10.98 87 389884 3501 42227863
Spinal stenosis 30.60 10.98 128 389843 6278 42225086
Learning disorder 30.58 10.98 44 389927 1069 42230295
Nephropathy toxic 30.46 10.98 68 389903 16770 42214594
Upper respiratory tract infection 30.13 10.98 548 389423 41625 42189739
Exposure during pregnancy 29.93 10.98 156 389815 8392 42222972
Chronic graft versus host disease 29.82 10.98 9 389962 6016 42225348
Brain oedema 29.48 10.98 66 389905 16261 42215103
Premature baby 29.48 10.98 333 389638 22820 42208544
Asphyxia 29.44 10.98 20 389951 8306 42223058
Myoclonus 29.20 10.98 71 389900 16994 42214370
Hypoglycaemia 29.18 10.98 379 389592 59475 42171889
Needle fatigue 29.09 10.98 45 389926 1168 42230196
Vomiting 28.96 10.98 2270 387701 287453 41943911
Metabolic acidosis 28.86 10.98 319 389652 51539 42179825
Akathisia 28.60 10.98 32 389939 10419 42220945
Polyomavirus-associated nephropathy 28.50 10.98 8 389963 5607 42225757
Cytokine release syndrome 28.46 10.98 265 389706 44262 42187102
Electrocardiogram QRS complex prolonged 28.28 10.98 9 389962 5814 42225550
Hyperkalaemia 28.26 10.98 542 389429 79916 42151448
Delirium 28.08 10.98 326 389645 52193 42179171
Hypospadias 28.05 10.98 84 389887 3483 42227881
Graft versus host disease 27.90 10.98 47 389924 12878 42218486
Productive cough 27.90 10.98 643 389328 50924 42180440
Alanine aminotransferase abnormal 27.82 10.98 104 389867 4840 42226524
Urinary tract infection 27.82 10.98 1142 388829 98142 42133222
Exposure to toxic agent 27.59 10.98 6 389965 4998 42226366
Nephrolithiasis 27.52 10.98 482 389489 36348 42195016
Endophthalmitis 27.30 10.98 4 389967 4429 42226935
Jaundice neonatal 27.16 10.98 61 389910 2118 42229246
Syndactyly 27.09 10.98 38 389933 901 42230463
Muscle spasticity 27.07 10.98 129 389842 6693 42224671
Schizophrenia 26.85 10.98 177 389794 10373 42220991
Mean cell volume increased 26.81 10.98 88 389883 3835 42227529
Haemodynamic instability 26.79 10.98 46 389925 12511 42218853
Diffuse large B-cell lymphoma recurrent 26.66 10.98 6 389965 4880 42226484
Cytomegalovirus chorioretinitis 26.53 10.98 5 389966 4606 42226758
C-reactive protein abnormal 26.45 10.98 160 389811 9101 42222263
Anaphylactic reaction 26.21 10.98 257 389714 42486 42188878
Attention deficit hyperactivity disorder 26.17 10.98 75 389896 3033 42228331
Right atrial hypertrophy 26.15 10.98 33 389938 704 42230660
Atrial septal defect 26.01 10.98 142 389829 7777 42223587
Dysstasia 26 10.98 219 389752 13867 42217497
Frequent bowel movements 25.96 10.98 305 389666 21102 42210262
Blood creatine phosphokinase increased 25.86 10.98 300 389671 48038 42183326
Sopor 25.83 10.98 51 389920 13151 42218213
Maternal exposure during breast feeding 25.82 10.98 49 389922 1506 42229858
Tumour lysis syndrome 25.80 10.98 110 389861 22121 42209243
Status epilepticus 25.73 10.98 66 389905 15512 42215852
Mobility decreased 25.65 10.98 460 389511 34846 42196518
Foetal malformation 25.56 10.98 18 389953 175 42231189
Myocardial infarction 25.51 10.98 903 389068 123106 42108258
Hepatitis 25.40 10.98 146 389825 27154 42204210
Hyperhidrosis 25.37 10.98 632 389339 89880 42141484
Joint laxity 25.36 10.98 25 389946 401 42230963
Maternal drugs affecting foetus 25.25 10.98 85 389886 3754 42227610
Delusion of grandeur 25.01 10.98 56 389915 1940 42229424
Neuritis 24.96 10.98 118 389853 6102 42225262
Rheumatoid nodule 24.96 10.98 72 389899 2923 42228441
Mydriasis 24.95 10.98 26 389945 8744 42222620
Depressive symptom 24.86 10.98 3 389968 3850 42227514
Wrong technique in product usage process 24.63 10.98 260 389711 42375 42188989
Pulmonary vasculitis 24.51 10.98 118 389853 6148 42225216
Polydactyly 24.47 10.98 42 389929 1192 42230172
Neutropenia 24.26 10.98 1536 388435 197895 42033469
Epidural lipomatosis 24.26 10.98 52 389919 1748 42229616
Cerebral infarction 24.25 10.98 176 389795 30993 42200371
Mite allergy 24.24 10.98 101 389870 4945 42226419
Urticaria 24.12 10.98 505 389466 73531 42157833
Ascites 24.04 10.98 369 389602 56309 42175055
Haematocrit decreased 24.03 10.98 451 389520 34457 42196907
Foot deformity 24.00 10.98 101 389870 4967 42226397
Appendicitis 23.92 10.98 102 389869 20511 42210853
Acute generalised exanthematous pustulosis 23.87 10.98 26 389945 8569 42222795
Melaena 23.74 10.98 233 389738 38513 42192851
Localised infection 23.71 10.98 288 389683 20085 42211279
Incorrect route of product administration 23.69 10.98 128 389843 24177 42207187
Aggression 23.66 10.98 274 389697 43889 42187475
Hypertonic bladder 23.60 10.98 61 389910 2320 42229044
Nocardiosis 23.52 10.98 9 389962 5181 42226183
Adenovirus infection 23.22 10.98 17 389954 6792 42224572
Coagulopathy 23.13 10.98 114 389857 22048 42209316
Aplastic anaemia 23.10 10.98 193 389778 12191 42219173
Drug-induced liver injury 23.10 10.98 231 389740 38042 42193322
Loss of consciousness 22.71 10.98 657 389314 91697 42139667
Musculoskeletal pain 22.69 10.98 430 389541 32910 42198454
Skin cancer 22.66 10.98 181 389790 11281 42220083
Syringe issue 22.55 10.98 27 389944 8529 42222835
Colorectal cancer 22.40 10.98 9 389962 5029 42226335
Bronchial secretion retention 22.32 10.98 47 389924 1560 42229804
Respiratory symptom 22.30 10.98 176 389795 10930 42220434
Right ventricular hypertrophy 22.27 10.98 46 389925 1506 42229858
Euglycaemic diabetic ketoacidosis 22.24 10.98 12 389959 5648 42225716
Unresponsive to stimuli 22.24 10.98 182 389789 31221 42200143
Back disorder 22.21 10.98 131 389840 7383 42223981
Acute chest syndrome 22.11 10.98 37 389934 1028 42230336
Neurodevelopmental disorder 22.08 10.98 24 389947 434 42230930
Mycotic allergy 22.03 10.98 96 389875 4795 42226569
Sleep apnoea syndrome 21.99 10.98 298 389673 21310 42210054
Withdrawal syndrome 21.87 10.98 66 389905 14709 42216655
Bradycardia neonatal 21.80 10.98 42 389929 1306 42230058
Blood pressure increased 21.78 10.98 1141 388830 100787 42130577
Bronchitis 21.77 10.98 576 389395 46625 42184739
Dandy-Walker syndrome 21.75 10.98 19 389952 259 42231105
Victim of child abuse 21.67 10.98 39 389932 1150 42230214
Device leakage 21.65 10.98 38 389933 10247 42221117
Contusion 21.63 10.98 520 389451 41465 42189899
Rhinorrhoea 21.62 10.98 410 389561 31384 42199980
Diarrhoea 21.59 10.98 4648 385323 456201 41775163
Tachycardia 21.50 10.98 733 389238 100354 42131010
Eosinophilic granulomatosis with polyangiitis 21.43 10.98 144 389827 8494 42222870
Multimorbidity 21.42 10.98 34 389937 903 42230461
Drug dependence 21.35 10.98 167 389804 28927 42202437
Dysgraphia 21.29 10.98 61 389910 2467 42228897
Gastrooesophageal reflux disease 21.23 10.98 551 389420 44472 42186892
Rhinalgia 21.19 10.98 50 389921 1794 42229570
Hepatotoxicity 21.12 10.98 139 389832 25028 42206336
Hypermobility syndrome 21.05 10.98 21 389950 342 42231022
Congenital central nervous system anomaly 21.04 10.98 29 389942 676 42230688
Spinal fracture 20.91 10.98 150 389821 9040 42222324
Pneumonia aspiration 20.91 10.98 327 389644 49751 42181613
Disinhibition 20.82 10.98 5 389966 3890 42227474
Lower respiratory tract infection 20.82 10.98 509 389462 40697 42190667
Bradycardia 20.80 10.98 609 389362 84875 42146489
Serum ferritin increased 20.79 10.98 125 389846 7094 42224270
Torsade de pointes 20.71 10.98 29 389942 8565 42222799
Hepatitis B reactivation 20.64 10.98 8 389963 4570 42226794
Cataract 20.59 10.98 394 389577 30210 42201154
Dust allergy 20.56 10.98 100 389871 5232 42226132
Maternal exposure before pregnancy 20.50 10.98 36 389935 1041 42230323
Atrioventricular septal defect 20.33 10.98 18 389953 250 42231114
Full blood count decreased 20.29 10.98 282 389689 20278 42211086
Vitamin B12 deficiency 20.21 10.98 94 389877 4828 42226536
Nocturia 20.12 10.98 184 389787 11928 42219436
Hypercalcaemia 20.03 10.98 253 389718 17805 42213559
Inguinal hernia 20.01 10.98 145 389826 8767 42222597
Pyrexia 20.00 10.98 3234 386737 390808 41840556
Haemoglobin decreased 19.93 10.98 1438 388533 131033 42100331
Knee arthroplasty 19.79 10.98 143 389828 8638 42222726
Virologic failure 19.70 10.98 6 389965 3988 42227376
Red cell distribution width increased 19.69 10.98 120 389851 6844 42224520
Systemic infection 19.63 10.98 97 389874 5108 42226256
Plasma cell myeloma 19.53 10.98 572 389399 47006 42184358
Mucocutaneous ulceration 19.49 10.98 24 389947 499 42230865
Spirometry abnormal 19.48 10.98 96 389875 5050 42226314
Headache 19.38 10.98 2487 387484 236882 41994482
Lipodystrophy acquired 19.30 10.98 4 389967 3446 42227918
Cerebral haemorrhage 19.26 10.98 246 389725 38720 42192644
Hyperparathyroidism 19.23 10.98 39 389932 1260 42230104
Macrocephaly 19.21 10.98 23 389948 464 42230900
Transplant rejection 19.19 10.98 62 389909 13526 42217838
Obsessive-compulsive disorder 19.17 10.98 20 389951 6723 42224641
Exposure via breast milk 19.17 10.98 58 389913 2419 42228945
Hip fracture 19.11 10.98 198 389773 13274 42218090
Drug eruption 19.08 10.98 128 389843 22947 42208417
Respiratory disorder neonatal 19.04 10.98 50 389921 1920 42229444
Squamous cell carcinoma of skin 18.99 10.98 189 389782 12537 42218827
Aortic valve stenosis 18.95 10.98 66 389905 2966 42228398
Rebound effect 18.70 10.98 24 389947 7355 42224009
Arteriosclerosis 18.68 10.98 249 389722 17740 42213624
Potentiating drug interaction 18.60 10.98 19 389952 6449 42224915
Astigmatism 18.57 10.98 39 389932 1292 42230072
Hand deformity 18.55 10.98 76 389895 3692 42227672
Renal cyst haemorrhage 18.55 10.98 27 389944 663 42230701
Hyperammonaemia 18.50 10.98 27 389944 7839 42223525
Blood pressure diastolic decreased 18.46 10.98 160 389811 10215 42221149
Finger deformity 18.43 10.98 44 389927 1591 42229773
Viral mutation identified 18.36 10.98 4 389967 3327 42228037
Malignant melanoma 18.34 10.98 148 389823 9252 42222112
Plagiocephaly 18.33 10.98 25 389946 577 42230787
Rib fracture 18.31 10.98 232 389739 16339 42215025
Fracture 18.29 10.98 132 389839 7971 42223393
Osteopenia 18.27 10.98 109 389862 6169 42225195
Central nervous system lesion 18.22 10.98 129 389842 7741 42223623
Soft tissue mass 18.20 10.98 33 389938 979 42230385
Hypokalaemia 18.19 10.98 508 389463 71213 42160151
Spinal osteoarthritis 18.19 10.98 139 389832 8547 42222817
Anuria 18.18 10.98 50 389921 11482 42219882
Umbilical hernia 18.11 10.98 98 389873 5349 42226015
Conjunctivitis allergic 18.09 10.98 104 389867 5807 42225557
Abdominal wall haemorrhage 18.07 10.98 23 389948 495 42230869
Encephalopathy 17.90 10.98 268 389703 41065 42190299
Treatment failure 17.89 10.98 436 389535 62188 42169176
Hepatitis B 17.87 10.98 21 389950 6690 42224674
Blood pressure diastolic increased 17.87 10.98 110 389861 6295 42225069
Disseminated aspergillosis 17.85 10.98 45 389926 1685 42229679
Weight increased 17.78 10.98 1181 388790 106802 42124562
Oropharyngeal pain 17.70 10.98 512 389459 41998 42189366
Folate deficiency 17.70 10.98 45 389926 1694 42229670
Cytopenia 17.69 10.98 91 389880 17406 42213958
Acute graft versus host disease in intestine 17.66 10.98 7 389964 3944 42227420
Large for dates baby 17.59 10.98 31 389940 899 42230465
Liver injury 17.49 10.98 103 389868 19045 42212319
Body height decreased 17.35 10.98 79 389892 4021 42227343
Sepsis 17.30 10.98 1579 388392 197755 42033609
Fistula discharge 17.28 10.98 34 389937 1074 42230290
Inappropriate schedule of product administration 17.27 10.98 1057 388914 94845 42136519
Hypersomnia 17.16 10.98 207 389764 14411 42216953
Dry throat 17.13 10.98 62 389909 2840 42228524
Ankylosing spondylitis 17.13 10.98 117 389854 6939 42224425
Hypochromasia 17.11 10.98 18 389953 313 42231051
Hyperparathyroidism secondary 17.04 10.98 46 389925 1796 42229568
Asthenia 16.97 10.98 2869 387102 277924 41953440
Epstein-Barr virus infection 16.97 10.98 40 389931 9678 42221686
Dystonia 16.95 10.98 60 389911 12730 42218634
Hyponatraemia 16.92 10.98 757 389214 100705 42130659
Hot flush 16.87 10.98 293 389678 22058 42209306
Foetal growth restriction 16.86 10.98 94 389877 5189 42226175
Candida infection 16.82 10.98 122 389849 21488 42209876
Hydrocele 16.82 10.98 57 389914 2526 42228838
Melanoderma 16.75 10.98 14 389957 179 42231185
Congenital hand malformation 16.73 10.98 25 389946 629 42230735
Thymus disorder 16.72 10.98 16 389955 247 42231117
Ear infection 16.68 10.98 185 389786 12619 42218745
Tongue disorder 16.66 10.98 95 389876 5288 42226076
Blood 25-hydroxycholecalciferol decreased 16.58 10.98 18 389953 325 42231039
Limb injury 16.55 10.98 202 389769 14103 42217261
Dissociation 16.54 10.98 7 389964 3791 42227573
Urosepsis 16.48 10.98 210 389761 14810 42216554
Language disorder 16.45 10.98 55 389916 2420 42228944
Monoparesis 16.44 10.98 62 389909 2898 42228466
Developmental delay 16.32 10.98 65 389906 3117 42228247
Drug level increased 16.28 10.98 157 389814 26043 42205321
Night sweats 16.25 10.98 265 389706 19704 42211660
Spinal disorder 16.22 10.98 84 389887 4507 42226857
Oesophageal adenocarcinoma 16.20 10.98 31 389940 959 42230405
Drug dose omission by device 16.13 10.98 18 389953 5868 42225496
Red blood cell sedimentation rate increased 16.10 10.98 150 389821 9774 42221590
Bronchospasm 16.05 10.98 62 389909 12823 42218541
Monocyte percentage increased 16.01 10.98 32 389939 1023 42230341
Disease recurrence 15.94 10.98 184 389787 29494 42201870
Hepatitis cholestatic 15.93 10.98 42 389929 9782 42221582
Child abuse 15.93 10.98 29 389942 863 42230501
Proteinuria 15.91 10.98 134 389837 22849 42208515
Hypoacusis 15.90 10.98 250 389721 18452 42212912
Ventricular septal defect 15.90 10.98 81 389890 4318 42227046
Gastrointestinal infection 15.89 10.98 111 389860 6632 42224732
Apparent death 15.88 10.98 7 389964 3701 42227663
Impaired fasting glucose 15.79 10.98 17 389954 304 42231060
Tendonitis 15.78 10.98 149 389822 9745 42221619
Femur fracture 15.76 10.98 148 389823 9664 42221700
Pancreatitis 15.64 10.98 290 389681 42978 42188386
Hydrops foetalis 15.63 10.98 29 389942 876 42230488
Abdominal adhesions 15.62 10.98 43 389928 1699 42229665
Gastric haemorrhage 15.54 10.98 47 389924 10468 42220896
Eosinophil percentage increased 15.53 10.98 23 389948 574 42230790
Methaemoglobinaemia 15.45 10.98 18 389953 5756 42225608
Neck pain 15.23 10.98 371 389600 29643 42201721
Hypophosphatasia 15.20 10.98 8 389963 43 42231321
Benign prostatic hyperplasia 15.19 10.98 274 389697 20778 42210586
Motor developmental delay 15.16 10.98 25 389946 686 42230678
Reticulocyte count increased 15.15 10.98 27 389944 790 42230574
Talipes 15.14 10.98 50 389921 2186 42229178
Polyarthritis 15.10 10.98 89 389882 5015 42226349
Ultrasound antenatal screen 15.06 10.98 22 389949 542 42230822
Enterocolitis 14.95 10.98 44 389927 9885 42221479
Dyspraxia 14.94 10.98 20 389951 453 42230911
Rectal prolapse 14.94 10.98 22 389949 546 42230818
Impaired healing 14.90 10.98 229 389742 16824 42214540
Pruritus genital 14.89 10.98 3 389968 2636 42228728
Knee deformity 14.78 10.98 26 389945 753 42230611
Mucous stools 14.77 10.98 54 389917 2486 42228878
Prostate cancer stage I 14.75 10.98 3 389968 2618 42228746
Urge incontinence 14.74 10.98 22 389949 553 42230811
Hepatic encephalopathy 14.73 10.98 89 389882 16353 42215011
Hyperthermia 14.72 10.98 62 389909 12512 42218852
Hepatocellular injury 14.67 10.98 142 389829 23536 42207828
Acne 14.65 10.98 190 389781 13454 42217910
Middle ear effusion 14.61 10.98 26 389945 760 42230604
Psychotic disorder 14.58 10.98 184 389787 29024 42202340
Arthrodesis 14.56 10.98 22 389949 559 42230805
Vascular compression 14.55 10.98 18 389953 376 42230988
Ileal stenosis 14.47 10.98 44 389927 1840 42229524
Spinal pain 14.46 10.98 109 389862 6673 42224691
Nerve compression 14.44 10.98 74 389897 3954 42227410
Parosmia 14.42 10.98 120 389851 7571 42223793
Cyst 14.41 10.98 91 389880 5255 42226109
Toxic encephalopathy 14.36 10.98 26 389945 6927 42224437
Mania 14.30 10.98 49 389922 10498 42220866
Viral infection 14.29 10.98 287 389684 22196 42209168
Vein disorder 14.23 10.98 47 389924 2055 42229309
Pancreatic failure 14.19 10.98 31 389940 1056 42230308
Inflammation 14.19 10.98 408 389563 33439 42197925
Caesarean section 14.18 10.98 47 389924 2059 42229305
Prostate cancer stage IV 14.10 10.98 3 389968 2537 42228827
Pulmonary haemorrhage 14.10 10.98 55 389916 11342 42220022
C-reactive protein increased 14.08 10.98 714 389257 62846 42168518
Hyperglycaemia 14.01 10.98 316 389655 45543 42185821
Affective disorder 13.98 10.98 98 389873 5862 42225502
Human herpesvirus 6 infection 13.98 10.98 3 389968 2522 42228842
Temperature regulation disorder 13.95 10.98 32 389939 1127 42230237
Diabetic ketoacidosis 13.91 10.98 134 389837 22233 42209131
Anal fistula 13.90 10.98 101 389870 6112 42225252
Dyslexia 13.89 10.98 17 389954 351 42231013
Cryptococcosis 13.85 10.98 6 389965 3205 42228159
Lymphoedema 13.82 10.98 85 389886 4863 42226501
Klebsiella infection 13.82 10.98 55 389916 11277 42220087
Hypertransaminasaemia 13.81 10.98 41 389930 9186 42222178
Muscle rigidity 13.79 10.98 60 389911 11999 42219365
Distributive shock 13.75 10.98 3 389968 2493 42228871
Right atrial enlargement 13.72 10.98 15 389956 273 42231091
Hypoaesthesia 13.69 10.98 792 389179 70671 42160693
Lip swelling 13.68 10.98 110 389861 18943 42212421
Prescription drug used without a prescription 13.65 10.98 4 389967 2726 42228638
Haemophagocytic lymphohistiocytosis 13.65 10.98 104 389867 18118 42213246
Neoplasm progression 13.63 10.98 185 389786 28815 42202549
Gastrointestinal stoma complication 13.59 10.98 38 389933 1515 42229849
Arteriospasm coronary 13.53 10.98 14 389957 4724 42226640
Paradoxical drug reaction 13.53 10.98 14 389957 4724 42226640
Psychomotor hyperactivity 13.48 10.98 53 389918 10905 42220459
SARS-CoV-2 test positive 13.48 10.98 125 389846 8135 42223229
Streptobacillus infection 13.45 10.98 5 389966 9 42231355
Kidney infection 13.43 10.98 107 389864 6663 42224701
Flatulence 13.40 10.98 313 389658 24839 42206525
Joint stiffness 13.40 10.98 172 389799 12150 42219214
Pulmonary oedema 13.34 10.98 378 389593 52894 42178470
Pseudomonas infection 13.33 10.98 88 389883 15835 42215529
Full blood count abnormal 13.32 10.98 363 389608 29513 42201851
Blood pressure abnormal 13.27 10.98 145 389826 9853 42221511
Catatonia 13.18 10.98 23 389948 6216 42225148
Graft versus host disease in skin 13.15 10.98 17 389954 5195 42226169
Lymphocyte count abnormal 13.15 10.98 47 389924 2140 42229224
Therapeutic product effect variable 13.11 10.98 6 389965 3103 42228261
Movement disorder 13.08 10.98 198 389773 14500 42216864
Agranulocytosis 13.08 10.98 199 389772 30413 42200951
Vasoplegia syndrome 13.08 10.98 4 389967 2651 42228713
Angina pectoris 13 10.98 217 389754 32679 42198685
Inflammatory marker increased 12.98 10.98 106 389865 6650 42224714
Shock haemorrhagic 12.98 10.98 91 389880 16151 42215213
Viral acanthoma 12.98 10.98 6 389965 23 42231341
Post procedural infection 12.92 10.98 94 389877 5691 42225673
Renal injury 12.91 10.98 63 389908 12217 42219147
Cholelithiasis 12.90 10.98 292 389679 23054 42208310
Latent tuberculosis 12.90 10.98 39 389932 1626 42229738
Strabismus 12.89 10.98 49 389922 2299 42229065
Compartment syndrome 12.89 10.98 7 389964 3282 42228082
Influenza like illness 12.85 10.98 382 389589 31458 42199906
Phospholipidosis 12.84 10.98 8 389963 62 42231302
Acute myeloid leukaemia 12.74 10.98 136 389835 22120 42209244
Pre-eclampsia 12.69 10.98 7 389964 42 42231322
Bronchial wall thickening 12.62 10.98 34 389937 1326 42230038
Microcephaly 12.61 10.98 27 389944 907 42230457
Pollakiuria 12.60 10.98 282 389689 22223 42209141
Vitamin B complex deficiency 12.57 10.98 19 389952 483 42230881
Laboratory test abnormal 12.57 10.98 287 389684 22691 42208673
Vascular stent thrombosis 12.56 10.98 7 389964 3235 42228129
Agitation neonatal 12.55 10.98 35 389936 1393 42229971
Ear disorder 12.55 10.98 44 389927 1984 42229380
Diaphragmatic disorder 12.54 10.98 32 389939 1207 42230157
Paranoia 12.52 10.98 76 389895 13950 42217414
Phlebitis infective 12.48 10.98 10 389961 120 42231244
Normochromic normocytic anaemia 12.47 10.98 132 389839 8899 42222465
Heparin-induced thrombocytopenia 12.46 10.98 26 389945 6571 42224793
Haemorrhage intracranial 12.46 10.98 99 389872 17093 42214271
Burns second degree 12.46 10.98 97 389874 5999 42225365
Bowel movement irregularity 12.38 10.98 64 389907 3432 42227932
White blood cells urine positive 12.36 10.98 35 389936 1406 42229958
Scoliosis 12.32 10.98 59 389912 3067 42228297
Blood parathyroid hormone decreased 12.27 10.98 38 389933 1605 42229759
Arrhythmia 12.26 10.98 278 389693 40039 42191325
Pectus excavatum 12.23 10.98 13 389958 229 42231135
Cystic fibrosis 12.21 10.98 44 389927 2011 42229353
Total lung capacity abnormal 12.21 10.98 76 389895 4367 42226997
Renal aplasia 12.18 10.98 24 389947 759 42230605
Low turnover osteopathy 12.17 10.98 9 389962 95 42231269
Anhedonia 12.14 10.98 33 389938 7607 42223757
Medical device implantation 12.13 10.98 21 389950 600 42230764
Foetal disorder 12.12 10.98 29 389942 1050 42230314
Weight gain poor 12.11 10.98 33 389938 1296 42230068
Intellectual disability 12.09 10.98 42 389929 1885 42229479
Sinus congestion 12.09 10.98 107 389864 6873 42224491
Drug screen positive 12.03 10.98 12 389959 4119 42227245
Ankyloglossia congenital 11.97 10.98 16 389955 362 42231002
Neurological symptom 11.96 10.98 142 389829 9849 42221515
Nasal disorder 11.93 10.98 43 389928 1966 42229398
Lacrimal disorder 11.92 10.98 15 389956 319 42231045
Respiratory acidosis 11.92 10.98 25 389946 6306 42225058
Urine calcium/creatinine ratio increased 11.90 10.98 6 389965 29 42231335
Bone marrow failure 11.90 10.98 222 389749 32871 42198493
Congenital hydronephrosis 11.88 10.98 24 389947 773 42230591
Fibula fracture 11.85 10.98 30 389941 1126 42230238
Left ventricular hypertrophy 11.85 10.98 134 389837 9185 42222179
Suture rupture 11.84 10.98 18 389953 460 42230904
Venoocclusive disease 11.84 10.98 11 389960 3904 42227460
Accessory spleen 11.83 10.98 10 389961 130 42231234
Atopy 11.82 10.98 27 389944 948 42230416
Drug abuser 11.81 10.98 9 389962 3522 42227842
Hernia 11.80 10.98 154 389817 10919 42220445
Trisomy 21 11.79 10.98 20 389951 562 42230802
Ageusia 11.79 10.98 160 389811 11445 42219919
Circulatory collapse 11.76 10.98 149 389822 23487 42207877
Chronic gastrointestinal bleeding 11.74 10.98 15 389956 324 42231040
Hyperbilirubinaemia neonatal 11.69 10.98 25 389946 839 42230525
Hepatitis fulminant 11.69 10.98 17 389954 4942 42226422
Weight decrease neonatal 11.67 10.98 15 389956 326 42231038
Oesophageal perforation 11.62 10.98 31 389940 1202 42230162
Pulseless electrical activity 11.57 10.98 39 389932 8398 42222966
Vena cava injury 11.57 10.98 15 389956 329 42231035
Product prescribing error 11.57 10.98 317 389654 25795 42205569
Hand fracture 11.57 10.98 55 389916 2851 42228513
Fistula 11.56 10.98 117 389854 7795 42223569
Selective eating disorder 11.55 10.98 39 389932 1725 42229639
Pneumonia bacterial 11.55 10.98 90 389881 15602 42215762
Congenital foot malformation 11.54 10.98 17 389954 422 42230942
Cleft lip and palate 11.51 10.98 26 389945 906 42230458
Joint range of motion decreased 11.50 10.98 115 389856 7638 42223726
Pneumothorax 11.50 10.98 149 389822 23394 42207970
Bronchiolitis 11.48 10.98 68 389903 3838 42227526
Joint instability 11.48 10.98 19 389952 523 42230841
Intraductal papillary mucinous neoplasm 11.48 10.98 18 389953 473 42230891
Clostridium test positive 11.47 10.98 88 389883 5417 42225947
Atypical fracture 11.43 10.98 11 389960 171 42231193
Hypogammaglobulinaemia 11.38 10.98 63 389908 11828 42219536
Wrong product administered 11.38 10.98 25 389946 6201 42225163
Aortic arteriosclerosis 11.32 10.98 83 389888 5037 42226327
Diverticulum 11.26 10.98 112 389859 7429 42223935
Blood parathyroid hormone increased 11.23 10.98 41 389930 1886 42229478
Respiratory distress 11.18 10.98 294 389677 41526 42189838
Blood test abnormal 11.16 10.98 173 389798 12733 42218631
Strongyloidiasis 11.15 10.98 9 389962 3422 42227942
SARS-CoV-2 antibody test positive 11.14 10.98 16 389955 388 42230976
Tooth fracture 11.14 10.98 71 389900 4113 42227251
Arthritis infective 11.13 10.98 70 389901 4036 42227328
Blood lactic acid increased 11.13 10.98 37 389934 8002 42223362
Diverticular perforation 11.12 10.98 65 389906 3651 42227713
Hypnopompic hallucination 11.11 10.98 3 389968 0 42231364
Excessive skin 11.11 10.98 3 389968 0 42231364
Nitrite urine 11.11 10.98 3 389968 0 42231364
Vascular anastomotic haemorrhage 11.08 10.98 14 389957 299 42231065
Emotional distress 11.06 10.98 94 389877 15999 42215365
Blindness 11.06 10.98 108 389863 17870 42213494
Urinary hesitation 11.05 10.98 56 389915 2979 42228385
Steatorrhoea 11.03 10.98 24 389947 815 42230549
Hallucination, visual 11.03 10.98 131 389840 20889 42210475
Aphthous ulcer 11.03 10.98 92 389879 5809 42225555
Preterm premature rupture of membranes 11.01 10.98 8 389963 82 42231282

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 2095.50 10.66 1456 1258041 479099 108850703
Completed suicide 1865.26 10.66 270 1259227 242111 109087691
Drug abuse 1141.90 10.66 304 1259193 177107 109152695
Intentional overdose 810.24 10.66 250 1259247 132251 109197551
Drug interaction 761.00 10.66 3023 1256474 497160 108832642
Arthralgia 559.85 10.66 12200 1247297 767432 108562370
Death 469.40 10.66 5394 1254103 693475 108636327
Arthropathy 458.39 10.66 5151 1254346 282371 109047431
Hepatic function abnormal 435.02 10.66 237 1259260 89058 109240744
Cardiac arrest 433.78 10.66 1001 1258496 195752 109134050
Myelosuppression 431.79 10.66 270 1259227 94070 109235732
Overdose 427.06 10.66 1306 1258191 232488 109097314
Febrile neutropenia 415.97 10.66 2022 1257475 314745 109015057
Joint swelling 400.56 10.66 7178 1252319 435667 108894135
Systemic lupus erythematosus 392.93 10.66 4529 1254968 249809 109079993
Depressed level of consciousness 391.41 10.66 420 1259077 111858 109217944
Suicide attempt 382.95 10.66 367 1259130 103027 109226775
Pain 370.18 10.66 13820 1245677 941135 108388667
Fatigue 369.27 10.66 17147 1242350 1198811 108130991
Alopecia 367.34 10.66 6016 1253481 358737 108971065
Hand deformity 353.77 10.66 3927 1255570 214579 109115223
Multiple organ dysfunction syndrome 345.65 10.66 758 1258739 150952 109178850
Pemphigus 345.44 10.66 3852 1255645 210718 109119084
Rheumatoid arthritis 340.63 10.66 5044 1254453 294569 109035233
Glossodynia 338.74 10.66 3944 1255553 218060 109111742
Coma 334.28 10.66 515 1258982 117354 109212448
Drug resistance 329.38 10.66 115 1259382 56259 109273543
Synovitis 321.66 10.66 4640 1254857 269452 109060350
Abdominal discomfort 318.05 10.66 6274 1253223 387584 108942218
Drug ineffective for unapproved indication 300.66 10.66 440 1259057 102398 109227404
Wound 300.26 10.66 4031 1255466 230406 109099396
Acute kidney injury 293.18 10.66 5282 1254215 630148 108699654
Sedation 282.62 10.66 227 1259270 69456 109260346
Malignant neoplasm progression 276.55 10.66 1037 1258460 173530 109156272
Drug reaction with eosinophilia and systemic symptoms 276.34 10.66 316 1259181 81779 109248023
Cardio-respiratory arrest 275.36 10.66 565 1258932 115271 109214531
Anti-cyclic citrullinated peptide antibody positive 274.88 10.66 3227 1256270 178757 109151045
Serotonin syndrome 272.47 10.66 168 1259329 58985 109270817
Nasopharyngitis 269.41 10.66 6131 1253366 388230 108941572
Disease progression 264.26 10.66 1660 1257837 242374 109087428
Respiratory arrest 263.81 10.66 169 1259328 58130 109271672
Rhabdomyolysis 252.26 10.66 629 1258868 119772 109210030
Maternal exposure during pregnancy 245.41 10.66 4174 1255323 250709 109079093
Psoriatic arthropathy 241.19 10.66 3357 1256140 193404 109136398
Hypotension 235.04 10.66 4375 1255122 519474 108810328
Musculoskeletal stiffness 226.90 10.66 4461 1255036 275361 109054441
Pericarditis 221.48 10.66 3617 1255880 215497 109114305
Lactic acidosis 217.80 10.66 456 1259041 92355 109237447
Renal failure 213.23 10.66 1606 1257891 224968 109104834
Sinusitis 212.74 10.66 4645 1254852 292043 109037759
Respiratory failure 211.44 10.66 1508 1257989 213824 109115978
Pain in extremity 209.56 10.66 7137 1252360 479981 108849821
Peripheral swelling 206.42 10.66 6044 1253453 397990 108931812
Swelling 202.54 10.66 5334 1254163 345707 108984095
Cytomegalovirus infection 201.88 10.66 193 1259304 54251 109275551
Drug ineffective 201.03 10.66 14763 1244734 1505777 107824025
Poisoning deliberate 200.85 10.66 30 1259467 26301 109303501
Duodenal ulcer perforation 200.76 10.66 2989 1256508 174711 109155091
Osteoarthritis 196.74 10.66 3047 1256450 179576 109150226
Impaired healing 194.62 10.66 3236 1256261 193481 109136321
Femur fracture 188.92 10.66 1003 1258494 43466 109286336
Infusion related reaction 187.67 10.66 5676 1253821 375486 108954316
Helicobacter infection 185.52 10.66 3007 1256490 178870 109150932
Neutropenia 184.06 10.66 3078 1256419 371542 108958260
Shock 182.82 10.66 204 1259293 53384 109276418
Altered state of consciousness 181.05 10.66 234 1259263 57392 109272410
Hepatic failure 178.46 10.66 318 1259179 68421 109261381
Electrocardiogram QT prolonged 174.01 10.66 645 1258852 108315 109221487
Fall 173.86 10.66 8471 1251026 595011 108734791
Cardiac failure 171.31 10.66 1341 1258156 186285 109143517
Discomfort 169.99 10.66 3411 1256086 211296 109118506
Therapeutic product effect decreased 169.38 10.66 3807 1255690 240509 109089293
Disseminated intravascular coagulation 165.54 10.66 136 1259361 41150 109288652
Poisoning 163.90 10.66 63 1259434 29042 109300760
Weight increased 160.12 10.66 6066 1253431 413578 108916224
Angioedema 159.98 10.66 579 1258918 97921 109231881
Sickle cell anaemia with crisis 159.86 10.66 343 1259154 9202 109320600
Anaphylactic shock 154.15 10.66 217 1259280 51329 109278473
Thrombocytopenia 153.15 10.66 2924 1256573 345961 108983841
Ventricular tachycardia 153.09 10.66 207 1259290 49802 109280000
Intentional self-injury 152.94 10.66 121 1259376 37308 109292494
Ventricular fibrillation 150.22 10.66 149 1259348 41164 109288638
Agitation 148.59 10.66 721 1258776 112330 109217472
Intentional product misuse 147.47 10.66 897 1258600 132007 109197795
Metabolic acidosis 145.56 10.66 612 1258885 99132 109230670
Product use in unapproved indication 145.53 10.66 3929 1255568 443448 108886354
Suspected suicide 143.66 10.66 7 1259490 15192 109314610
Rheumatoid factor positive 143.52 10.66 2201 1257296 129439 109200363
Mydriasis 136.86 10.66 41 1259456 22116 109307686
Cardiogenic shock 136.82 10.66 279 1259218 57059 109272743
Acute hepatic failure 133.21 10.66 131 1259366 36337 109293465
Somnolence 132.34 10.66 2487 1257010 294962 109034840
Lower respiratory tract infection 131.02 10.66 3662 1255835 239444 109090358
Therapy partial responder 130.96 10.66 137 1259360 36924 109292878
Bradycardia 130.80 10.66 1136 1258361 154381 109175421
Drug use disorder 130.28 10.66 24 1259473 18050 109311752
Hyperhidrosis 130.25 10.66 1433 1258064 185865 109143937
Septic shock 130.15 10.66 1156 1258341 156372 109173430
Contusion 129.37 10.66 3528 1255969 229833 109099969
Folliculitis 129.20 10.66 2653 1256844 165000 109164802
Neuroleptic malignant syndrome 128.31 10.66 119 1259378 33940 109295862
Post transplant lymphoproliferative disorder 128.24 10.66 14 1259483 15599 109314203
Cytokine release syndrome 127.37 10.66 394 1259103 69912 109259890
Myocardial infarction 125.21 10.66 1491 1258006 190592 109139210
Anaphylactic reaction 123.91 10.66 777 1258720 113523 109216279
Neurotoxicity 122.94 10.66 181 1259316 42026 109287776
Interstitial lung disease 121.12 10.66 1009 1258488 138325 109191477
Sedation complication 120.37 10.66 38 1259459 19817 109309985
Sepsis 115.67 10.66 2840 1256657 324506 109005296
Acute respiratory distress syndrome 114.48 10.66 274 1259223 52924 109276878
Irritable bowel syndrome 114.12 10.66 2560 1256937 161655 109168147
Bronchopulmonary aspergillosis 111.72 10.66 105 1259392 29758 109300044
Miosis 110.52 10.66 56 1259441 21927 109307875
Hepatic enzyme increased 110.06 10.66 4586 1254911 316306 109013496
Acute graft versus host disease 109.85 10.66 10 1259487 12871 109316931
Posterior reversible encephalopathy syndrome 108.97 10.66 135 1259362 33726 109296076
Blood creatine phosphokinase increased 107.48 10.66 447 1259050 72630 109257172
Thrombotic microangiopathy 107.29 10.66 104 1259393 29045 109300757
Vitamin D decreased 106.57 10.66 344 1259153 11871 109317931
Contraindicated product administered 106.43 10.66 3637 1255860 244630 109085172
Aspergillus infection 105.69 10.66 82 1259415 25534 109304268
Blood pressure fluctuation 105.55 10.66 1310 1258187 73514 109256288
Brain oedema 105.41 10.66 119 1259378 30979 109298823
Renal impairment 104.76 10.66 1512 1257985 186933 109142869
Infective pulmonary exacerbation of cystic fibrosis 103.66 10.66 387 1259110 14384 109315418
Hypoglycaemia 103.55 10.66 835 1258662 115269 109214533
Hyperkalaemia 103.38 10.66 1017 1258480 134779 109195023
Pathogen resistance 103.32 10.66 36 1259461 17636 109312166
Torsade de pointes 102.95 10.66 65 1259432 22535 109307267
Blister 102.84 10.66 3352 1256145 224024 109105778
Cytomegalovirus infection reactivation 102.71 10.66 40 1259457 18293 109311509
Muscle injury 102.57 10.66 2210 1257287 138597 109191205
Fibromyalgia 102.24 10.66 2610 1256887 168299 109161503
Red blood cell sedimentation rate abnormal 99.49 10.66 546 1258951 23963 109305839
Vitamin D deficiency 99.26 10.66 447 1259050 18105 109311697
Tachycardia 99.24 10.66 1900 1257597 224745 109105057
Multiple sclerosis relapse 97.39 10.66 937 1258560 49303 109280499
Hypoaesthesia 96.94 10.66 4442 1255055 309781 109020021
Temperature regulation disorder 96.94 10.66 15 1259482 12811 109316991
Venoocclusive liver disease 96.02 10.66 27 1259470 15180 109314622
Abortion spontaneous 95.67 10.66 694 1258803 33588 109296214
Substance abuse 95.52 10.66 14 1259483 12449 109317353
General physical health deterioration 94.99 10.66 5832 1253665 419463 108910339
Psoriasis 94.64 10.66 2174 1257323 137819 109191983
Status epilepticus 94.31 10.66 133 1259364 31438 109298364
Sleep disorder due to general medical condition, insomnia type 94.05 10.66 1709 1257788 103934 109225868
Arthritis 92.96 10.66 2534 1256963 165052 109164750
Exposure to toxic agent 92.84 10.66 17 1259480 12841 109316961
Haematotoxicity 92.83 10.66 63 1259434 21019 109308783
Osteoporosis 92.61 10.66 1451 1258046 85701 109244101
Device adhesion issue 92.34 10.66 3 1259494 9307 109320495
Urinary tract infection 92.08 10.66 4572 1254925 321710 109008092
Myoclonus 91.79 10.66 146 1259351 32852 109296950
COVID-19 91.59 10.66 3535 1255962 241525 109088277
Cerebral infarction 90.75 10.66 295 1259202 51543 109278259
Knee arthroplasty 90.28 10.66 1134 1258363 63814 109265988
C-reactive protein abnormal 90.14 10.66 2022 1257475 127673 109202129
Mucormycosis 88.66 10.66 9 1259488 10619 109319183
Creatinine renal clearance decreased 88.53 10.66 71 1259426 21744 109308058
Palmar-plantar erythrodysaesthesia syndrome 88.52 10.66 211 1259286 40814 109288988
Sopor 87.90 10.66 177 1259320 36369 109293433
Encephalopathy 87.34 10.66 552 1258945 80503 109249299
Ascites 87.18 10.66 658 1258839 92150 109237652
Product dose omission issue 86.29 10.66 4487 1255010 317295 109012507
Coagulopathy 86.23 10.66 213 1259284 40698 109289104
Exposure during pregnancy 85.47 10.66 2505 1256992 164919 109164883
Toxic epidermal necrolysis 85.29 10.66 344 1259153 56383 109273419
Acute graft versus host disease in skin 84.83 10.66 11 1259486 10729 109319073
Joint effusion 84.38 10.66 465 1259032 20440 109309362
Stevens-Johnson syndrome 84.13 10.66 264 1259233 46637 109283165
Juvenile idiopathic arthritis 84.05 10.66 201 1259296 5806 109323996
Ill-defined disorder 83.98 10.66 2361 1257136 154492 109175310
Hepatotoxicity 83.50 10.66 404 1259093 62996 109266806
Asphyxia 83.03 10.66 29 1259468 14186 109315616
Grip strength decreased 82.99 10.66 1329 1258168 78845 109250957
Neurologic neglect syndrome 82.67 10.66 6 1259491 9292 109320510
Foot fracture 82.47 10.66 536 1258961 25010 109304792
Blood cholesterol increased 81.96 10.66 2718 1256779 182067 109147735
Low turnover osteopathy 81.94 10.66 108 1259389 1914 109327888
Blood pressure diastolic abnormal 81.73 10.66 539 1258958 25276 109304526
Musculoskeletal pain 81.67 10.66 2694 1256803 180329 109149473
Tooth disorder 80.98 10.66 595 1258902 28914 109300888
Unresponsive to stimuli 80.85 10.66 412 1259085 63378 109266424
Cardiotoxicity 80.48 10.66 46 1259451 16835 109312967
Hyponatraemia 80.24 10.66 1876 1257621 215777 109114025
BK virus infection 79.60 10.66 25 1259472 13081 109316721
Drug withdrawal syndrome 79.53 10.66 199 1259298 37855 109291947
Blood pressure systolic abnormal 79.37 10.66 520 1258977 24330 109305472
Aggression 78.74 10.66 376 1259121 58834 109270968
Hemiplegia 78.51 10.66 86 1259411 22696 109307106
Intervertebral disc degeneration 78.24 10.66 410 1259087 17675 109312127
Multiple-drug resistance 77.31 10.66 27 1259470 13208 109316594
Graft versus host disease 76.58 10.66 61 1259436 18745 109311057
Graft versus host disease in gastrointestinal tract 76.38 10.66 7 1259490 8961 109320841
Transplant rejection 75.89 10.66 101 1259396 24466 109305336
Rheumatic fever 75.68 10.66 1880 1257617 120699 109209103
Hip arthroplasty 74.40 10.66 967 1258530 54846 109274956
Pulmonary oedema 74.05 10.66 760 1258737 99899 109229903
Neutrophil count decreased 73.81 10.66 952 1258545 119989 109209813
Respiratory depression 73.58 10.66 159 1259338 31842 109297960
Inflammation 73.50 10.66 2793 1256704 190445 109139357
Carotid artery thrombosis 73.47 10.66 11 1259486 9627 109320175
Blood pressure systolic increased 73.32 10.66 1341 1258156 81650 109248152
Acute generalised exanthematous pustulosis 73.32 10.66 83 1259414 21581 109308221
Weight decreased 72.56 10.66 6232 1253265 461825 108867977
Personality disorder 71.93 10.66 28 1259469 12809 109316993
Seizure 71.69 10.66 1943 1257554 219242 109110560
Gait disturbance 71.28 10.66 3863 1255634 274345 109055457
Loss of consciousness 70.42 10.66 1699 1257798 194607 109135195
Angina pectoris 70.37 10.66 418 1259079 61877 109267925
Suicidal ideation 70.03 10.66 707 1258790 93230 109236572
Intentional product use issue 69.96 10.66 3474 1256023 244432 109085370
Drug level increased 69.48 10.66 293 1259204 47426 109282376
Drug dependence 69.26 10.66 313 1259184 49707 109280095
Spinal osteoarthritis 68.56 10.66 429 1259068 19754 109310048
Hepatocellular injury 68.27 10.66 320 1259177 50322 109279480
Fracture 68.13 10.66 500 1258997 24288 109305514
Akathisia 66.61 10.66 58 1259439 17055 109312747
Mobility decreased 66.56 10.66 3325 1256172 234097 109095705
Tooth fracture 66.55 10.66 312 1259185 12855 109316947
Stomatitis 66.41 10.66 3738 1255759 266504 109063298
Cognitive disorder 65.92 10.66 657 1258840 86854 109242948
Tumour lysis syndrome 65.20 10.66 160 1259337 30641 109299161
Intercepted product preparation error 64.91 10.66 3 1259494 6817 109322985
Cardiac failure congestive 64.81 10.66 1270 1258227 149730 109180072
Proteinuria 64.46 10.66 236 1259261 39782 109290020
Wrong technique in product usage process 64.46 10.66 659 1258838 86689 109243113
Haemophagocytic lymphohistiocytosis 64.43 10.66 167 1259330 31392 109298410
Electrocardiogram QRS complex prolonged 64.22 10.66 34 1259463 12987 109316815
Ejection fraction decreased 63.95 10.66 244 1259253 40636 109289166
Appendicolith 63.57 10.66 42 1259455 14213 109315589
Polyomavirus-associated nephropathy 63.35 10.66 9 1259488 8192 109321610
Epstein-Barr virus infection 63.18 10.66 72 1259425 18666 109311136
Chronic graft versus host disease 63.14 10.66 15 1259482 9442 109320360
Pregnancy 62.80 10.66 872 1258625 50195 109279607
Basal cell carcinoma 62.74 10.66 790 1258707 44480 109285322
Swollen joint count increased 62.49 10.66 1318 1258179 82343 109247459
Dystonia 62.04 10.66 125 1259372 25680 109304122
Foot deformity 61.32 10.66 832 1258665 47648 109282154
Bone giant cell tumour 60.74 10.66 28 1259469 80 109329722
Psychotic disorder 60.65 10.66 336 1259161 50601 109279201
Platelet count decreased 59.81 10.66 2085 1257412 228358 109101444
Bone loss 59.69 10.66 117 1259380 2938 109326864
Eosinophilia 59.65 10.66 400 1259097 57536 109272266
Heart rate decreased 59.65 10.66 1297 1258200 81459 109248343
Spinal fracture 59.64 10.66 452 1259045 22181 109307621
Osteopenia 59.35 10.66 445 1259052 21764 109308038
Mental status changes 59.23 10.66 567 1258930 75555 109254247
Disability assessment scale score increased 58.80 10.66 142 1259355 4128 109325674
Bronchospasm 58.73 10.66 164 1259333 30075 109299727
Cerebral haemorrhage 58.03 10.66 467 1259030 64501 109265301
Off label use 57.60 10.66 15711 1243786 1484474 107845328
Blood bilirubin increased 57.37 10.66 570 1258927 75402 109254400
Condition aggravated 57.10 10.66 9362 1250135 725474 108604328
Rash maculo-papular 56.84 10.66 555 1258942 73667 109256135
Adenovirus infection 56.79 10.66 27 1259470 10967 109318835
Asthma-chronic obstructive pulmonary disease overlap syndrome 56.68 10.66 4 1259493 6340 109323462
Fracture delayed union 56.64 10.66 95 1259402 2106 109327696
Unintentional medical device removal 56.05 10.66 16 1259481 8907 109320895
Hyperthermia 55.58 10.66 98 1259399 21174 109308628
Hypoxia 55.37 10.66 1090 1258407 128425 109201377
Blood pressure diastolic decreased 55.31 10.66 639 1258858 35246 109294556
Product use issue 55.19 10.66 4193 1255304 307502 109022300
Haemodynamic instability 54.92 10.66 111 1259386 22777 109307025
Drug hypersensitivity 54.90 10.66 4438 1255059 449652 108880150
Respiratory distress 54.87 10.66 510 1258987 68364 109261438
Acute myeloid leukaemia 54.87 10.66 235 1259262 37875 109291927
Anuria 54.28 10.66 123 1259374 24218 109305584
Nephropathy toxic 54.13 10.66 148 1259349 27330 109302472
Localised infection 54.13 10.66 738 1258759 42310 109287492
Bronchitis 53.95 10.66 2245 1257252 154787 109175015
Nocardiosis 53.83 10.66 10 1259487 7476 109322326
Immune reconstitution inflammatory syndrome 52.94 10.66 64 1259433 16162 109313640
Gastrooesophageal reflux disease 52.84 10.66 2532 1256965 177444 109152358
Injection site reaction 52.59 10.66 1358 1258139 87712 109242090
Cytopenia 51.60 10.66 173 1259324 29943 109299859
Extrapyramidal disorder 51.42 10.66 163 1259334 28704 109301098
Hypokalaemia 51.28 10.66 1634 1257863 180814 109148988
Nodule 51.16 10.66 583 1258914 32048 109297754
Hyperglycaemia 51.11 10.66 672 1258825 84418 109245384
Diffuse large B-cell lymphoma recurrent 50.85 10.66 6 1259491 6293 109323509
Night sweats 50.80 10.66 1936 1257561 132047 109197755
Cystitis haemorrhagic 50.47 10.66 39 1259458 12170 109317632
Metastases to central nervous system 50.31 10.66 116 1259381 22701 109307101
Pyrexia 50.16 10.66 9238 1250259 889027 108440775
Bone disorder 49.69 10.66 412 1259085 20780 109309022
Paradoxical drug reaction 49.36 10.66 25 1259472 9792 109320010
Distributive shock 49.25 10.66 5 1259492 5899 109323903
Dysarthria 49.20 10.66 668 1258829 83453 109246349
Injection site pruritus 49.10 10.66 839 1258658 50419 109279383
Sinus tachycardia 48.97 10.66 301 1259196 44192 109285610
Oropharyngeal pain 48.78 10.66 1944 1257553 133332 109196470
Metastases to liver 48.05 10.66 223 1259274 35163 109294639
Hypothermia 47.92 10.66 147 1259350 26155 109303647
Face oedema 47.81 10.66 207 1259290 33262 109296540
Joint range of motion decreased 47.77 10.66 1767 1257730 120065 109209737
Systemic infection 47.69 10.66 230 1259267 9589 109320213
Gangrene 47.66 10.66 70 1259427 16271 109313531
Hypersensitivity 47.56 10.66 5277 1254220 398721 108931081
Toxic encephalopathy 47.56 10.66 62 1259435 15152 109314650
Joint stiffness 47.54 10.66 1051 1258446 66192 109263610
Type 2 diabetes mellitus 47.39 10.66 2471 1257026 174761 109155041
Restlessness 47.26 10.66 411 1259086 55848 109273954
Pneumothorax 46.95 10.66 224 1259273 35061 109294741
Respiratory acidosis 46.76 10.66 53 1259444 13773 109316029
Pulseless electrical activity 46.74 10.66 74 1259423 16683 109313119
Device expulsion 46.64 10.66 187 1259310 30704 109299098
Lip dry 46.39 10.66 1480 1258017 98603 109231199
Coordination abnormal 45.96 10.66 141 1259356 25087 109304715
Ear pain 45.95 10.66 857 1258640 52369 109277433
Red blood cell count decreased 45.86 10.66 1028 1258469 64895 109264907
Injection site erythema 45.86 10.66 1401 1258096 92775 109237027
Bone marrow failure 45.81 10.66 429 1259068 57419 109272383
Polyarthritis 45.72 10.66 371 1259126 18592 109311210
Gastrointestinal haemorrhage 45.41 10.66 1487 1258010 164031 109165771
Atypical femur fracture 45.37 10.66 165 1259332 6054 109323748
Synovial cyst 45.30 10.66 253 1259244 11177 109318625
Pleural effusion 44.71 10.66 1614 1257883 176095 109153707
Disease recurrence 44.68 10.66 459 1259038 60325 109269477
Colitis ulcerative 44.66 10.66 1176 1258321 76187 109253615
Enterocolitis 44.53 10.66 93 1259404 18856 109310946
Spinal stenosis 44.42 10.66 370 1259127 18686 109311116
Cytomegalovirus chorioretinitis 44.37 10.66 13 1259484 7115 109322687
Emotional distress 44.01 10.66 314 1259183 44533 109285269
Thoracic vertebral fracture 43.93 10.66 171 1259326 6484 109323318
Hyperammonaemia 43.92 10.66 55 1259442 13677 109316125
Wrist fracture 43.82 10.66 298 1259199 14119 109315683
Facet joint syndrome 43.62 10.66 1427 1258070 95401 109234401
Gait inability 43.56 10.66 1935 1257562 134441 109195361
Enthesopathy 43.50 10.66 267 1259230 12211 109317591
Anaemia 43.48 10.66 5511 1253986 541575 108788227
Arrhythmia 43.44 10.66 545 1258952 69030 109260772
Infection 43.31 10.66 4736 1254761 357464 108972338
Stress fracture 43.24 10.66 180 1259317 7041 109322761
Jaundice cholestatic 43.18 10.66 62 1259435 14546 109315256
Back pain 43.12 10.66 4842 1254655 366154 108963648
Hypomania 43.00 10.66 32 1259465 10178 109319624
Multiple sclerosis 42.97 10.66 465 1259032 25233 109304569
Pneumonia aspiration 42.63 10.66 659 1258838 80574 109249228
Dissociation 42.55 10.66 30 1259467 9812 109319990
Abnormal behaviour 42.50 10.66 265 1259232 38774 109291028
Pneumatosis intestinalis 42.47 10.66 22 1259475 8507 109321295
Endophthalmitis 42.45 10.66 20 1259477 8167 109321635
Muscle spasms 42.33 10.66 3699 1255798 274458 109055344
C-reactive protein increased 42.04 10.66 2952 1256545 214967 109114835
Stress cardiomyopathy 42.04 10.66 72 1259425 15734 109314068
Device difficult to use 41.95 10.66 95 1259402 18710 109311092
Blood creatinine increased 41.82 10.66 1680 1257817 181209 109148593
Coronary artery disease 41.66 10.66 570 1258927 71120 109258682
Bursitis 41.63 10.66 1844 1257653 128074 109201728
Inappropriate antidiuretic hormone secretion 41.56 10.66 221 1259276 33630 109296172
Disorientation 41.40 10.66 561 1258936 70110 109259692
Acute myocardial infarction 41.18 10.66 688 1258809 83089 109246713
Orthostatic hypotension 40.97 10.66 520 1258977 65729 109264073
Melaena 40.93 10.66 544 1258953 68213 109261589
International normalised ratio increased 40.90 10.66 718 1258779 86054 109243748
Tendonitis 40.89 10.66 466 1259031 25617 109304185
Red blood cell sedimentation rate increased 40.61 10.66 1174 1258323 77128 109252674
Wound infection 40.50 10.66 1410 1258087 95055 109234747
Tenderness 40.49 10.66 513 1258984 28924 109300878
Gestational diabetes 40.26 10.66 179 1259318 7210 109322592
Poor venous access 40.21 10.66 442 1259055 24080 109305722
Sciatica 39.90 10.66 1355 1258142 91044 109238758
Gastrointestinal disorder 39.89 10.66 3237 1256260 238715 109091087
Bone density abnormal 39.72 10.66 116 1259381 3787 109326015
Headache 39.70 10.66 10952 1248545 871425 108458377
Drug dose omission by device 39.65 10.66 65 1259432 14451 109315351
Withdrawal syndrome 39.58 10.66 203 1259294 31177 109298625
Memory impairment 39.42 10.66 2676 1256821 194268 109135534
Hepatitis B reactivation 39.25 10.66 18 1259479 7466 109322336
Human herpesvirus 6 infection 39.18 10.66 13 1259484 6568 109323234
Myopathy 39.03 10.66 149 1259348 24811 109304991
Device use error 38.91 10.66 28 1259469 9061 109320741
Vomiting 38.89 10.66 9490 1250007 901185 108428617
Leukopenia 38.88 10.66 1345 1258152 147446 109182356
Neck pain 38.87 10.66 1745 1257752 121385 109208417
Graft versus host disease in skin 38.63 10.66 23 1259474 8231 109321571
Bone density decreased 38.21 10.66 313 1259184 15729 109314073
Obesity 38.13 10.66 1617 1257880 111734 109218068
Gamma-glutamyltransferase increased 37.99 10.66 481 1259016 60828 109268974
Dyspepsia 37.91 10.66 2593 1256904 188372 109141430
Potentiating drug interaction 37.90 10.66 46 1259451 11597 109318205
Accidental exposure to product 37.84 10.66 375 1259122 49633 109280169
Colorectal cancer 37.82 10.66 29 1259468 9085 109320717
Blood lactic acid increased 37.73 10.66 77 1259420 15744 109314058
Drug intolerance 37.72 10.66 5232 1254265 401280 108928522
Aspartate aminotransferase increased 37.69 10.66 1464 1258033 158472 109171330
Acute graft versus host disease in intestine 37.54 10.66 9 1259488 5630 109324172
Accidental death 37.54 10.66 6 1259491 5003 109324799
Syncope 37.46 10.66 1904 1257593 200632 109129170
Second primary malignancy 37.35 10.66 95 1259402 17973 109311829
Mania 37.34 10.66 117 1259380 20679 109309123
Toxic skin eruption 37.01 10.66 174 1259323 27341 109302461
Acute chest syndrome 36.87 10.66 77 1259420 2026 109327776
Cross sensitivity reaction 36.83 10.66 9 1259488 5558 109324244
Loss of personal independence in daily activities 36.81 10.66 2075 1257422 147945 109181857
Hypogammaglobulinaemia 36.72 10.66 112 1259385 19964 109309838
Renal injury 36.71 10.66 101 1259396 18612 109311190
Road traffic accident 36.56 10.66 1534 1257963 105864 109223938
Haemorrhage intracranial 36.20 10.66 188 1259309 28781 109301021
Hyperbilirubinaemia 36.14 10.66 203 1259294 30468 109299334
Gait spastic 36.12 10.66 64 1259433 1485 109328317
Haemodialysis 35.99 10.66 94 1259403 17625 109312177
Ear infection 35.75 10.66 952 1258545 61780 109268022
Hallucination, visual 35.69 10.66 284 1259213 39321 109290481
Affect lability 35.51 10.66 102 1259395 18535 109311267
Acute coronary syndrome 35.47 10.66 139 1259358 22973 109306829
Generalised tonic-clonic seizure 35.39 10.66 425 1259072 54255 109275547
Muscle rigidity 35.33 10.66 147 1259350 23884 109305918
Pulmonary fibrosis 35.31 10.66 1460 1258037 100582 109229220
Bladder cancer 35.15 10.66 116 1259381 20176 109309626
Device leakage 35.05 10.66 82 1259415 15966 109313836
Influenza 34.96 10.66 2304 1257193 166797 109163005
Cardiospasm 34.94 10.66 7 1259490 4960 109324842
Acidosis 34.91 10.66 135 1259362 22396 109307406
Breast cancer 34.82 10.66 625 1258872 37917 109291885
Candida infection 34.68 10.66 364 1259133 47645 109282157
Toothache 34.65 10.66 416 1259081 23159 109306643
Maternal exposure before pregnancy 34.44 10.66 169 1259328 7096 109322706
Jaundice 34.42 10.66 471 1259026 58765 109271037
Circulatory collapse 34.40 10.66 318 1259179 42675 109287127
Neuropathy peripheral 34.38 10.66 1679 1257818 177598 109152204
Exostosis 34.32 10.66 724 1258773 45232 109284570
Hepatitis cholestatic 34.31 10.66 95 1259402 17471 109312331
Exposure via ingestion 34.28 10.66 7 1259490 4893 109324909
Dental caries 34.17 10.66 256 1259241 12517 109317285
Agranulocytosis 34.13 10.66 496 1259001 61264 109268538
Carpal tunnel syndrome 34.13 10.66 401 1259096 22209 109307593
Joint laxity 34.12 10.66 83 1259414 2424 109327378
Transplant dysfunction 33.93 10.66 27 1259470 8301 109321501
Food allergy 33.90 10.66 115 1259382 19833 109309969
Analgesic drug level increased 33.82 10.66 3 1259494 3943 109325859
Adjustment disorder 33.74 10.66 44 1259453 10751 109319051
Diabetic ketoacidosis 33.69 10.66 311 1259186 41747 109288055
Rash erythematous 33.68 10.66 693 1258804 81139 109248663
Live birth 33.38 10.66 1032 1258465 68452 109261350
Cyanosis 33.36 10.66 200 1259297 29541 109300261
Hyperthermia malignant 33.33 10.66 3 1259494 3897 109325905
Mouth ulceration 33.28 10.66 750 1258747 47388 109282414
Febrile bone marrow aplasia 32.98 10.66 96 1259401 17369 109312433
Skin toxicity 32.90 10.66 52 1259445 11731 109318071
Abdominal pain upper 32.84 10.66 4497 1255000 344614 108985188
Arterial occlusive disease 32.81 10.66 79 1259418 15229 109314573
Paranoia 32.81 10.66 137 1259360 22237 109307565
Blood pressure decreased 32.76 10.66 1029 1258468 114062 109215740
Malignant melanoma 32.72 10.66 315 1259182 16576 109313226
Metastases to lymph nodes 32.68 10.66 77 1259420 14955 109314847
Dry mouth 32.62 10.66 2673 1256824 197275 109132527
Ileus paralytic 32.58 10.66 52 1259445 11685 109318117
Total lung capacity increased 32.42 10.66 9 1259488 5103 109324699
Erythema multiforme 32.30 10.66 127 1259370 20970 109308832
Hypercalcaemia 32.28 10.66 727 1258770 45930 109283872
Ileus 32.21 10.66 211 1259286 30518 109299284
Hyperparathyroidism 32.07 10.66 106 1259391 3704 109326098
Joint destruction 31.97 10.66 224 1259273 10719 109319083
Vasoplegia syndrome 31.93 10.66 11 1259486 5428 109324374
Systemic candida 31.85 10.66 40 1259457 9934 109319868
Finger deformity 31.82 10.66 542 1258955 32550 109297252
Chest discomfort 31.82 10.66 1636 1257861 172212 109157590
Gastroenteritis viral 31.70 10.66 516 1258981 30710 109299092
Caesarean section 31.53 10.66 267 1259230 13550 109316252
Heparin-induced thrombocytopenia 31.35 10.66 51 1259446 11373 109318429
Cholestasis 31.33 10.66 531 1258966 63987 109265815
Anhedonia 31.22 10.66 82 1259415 15346 109314456
Strongyloidiasis 31.21 10.66 9 1259488 4977 109324825
Nephrolithiasis 31.17 10.66 981 1258516 65231 109264571
Drug eruption 31.05 10.66 427 1259070 53232 109276570
Acute myeloid leukaemia recurrent 30.86 10.66 10 1259487 5129 109324673
Cardiac failure acute 30.80 10.66 155 1259342 23923 109305879
Tardive dyskinesia 30.78 10.66 68 1259429 13511 109316291
Nervous system disorder 30.69 10.66 223 1259274 31498 109298304
Bradyphrenia 30.67 10.66 54 1259443 11674 109318128
Anal fissure 30.49 10.66 205 1259292 9676 109320126
Cytomegalovirus viraemia 30.46 10.66 102 1259395 17662 109312140
Latent tuberculosis 30.28 10.66 107 1259390 3870 109325932
Anosognosia 30.26 10.66 5 1259492 4069 109325733
Deep vein thrombosis postoperative 30.20 10.66 887 1258610 58404 109271398
Methaemoglobinaemia 30.08 10.66 36 1259461 9132 109320670
Anti-neutrophil cytoplasmic antibody positive vasculitis 30.05 10.66 12 1259485 5405 109324397
Kounis syndrome 29.92 10.66 15 1259482 5910 109323892
Hypoalbuminaemia 29.85 10.66 200 1259297 28774 109301028
Pseudomonas infection 29.84 10.66 190 1259307 27663 109302139
Multiple fractures 29.73 10.66 189 1259308 8751 109321051
Transaminases increased 29.72 10.66 525 1258972 62865 109266937
Cyst 29.70 10.66 303 1259194 16193 109313609
Gastric haemorrhage 29.67 10.66 88 1259409 15827 109313975
Type I hypersensitivity 29.66 10.66 18 1259479 6375 109323427
Epstein-Barr virus associated lymphoproliferative disorder 29.45 10.66 9 1259488 4793 109325009
Pruritus genital 29.38 10.66 19 1259478 6503 109323299
Blood lactate dehydrogenase increased 29.30 10.66 343 1259154 43991 109285811
Venoocclusive disease 29.29 10.66 18 1259479 6332 109323470
Pneumocystis jirovecii pneumonia 29.27 10.66 328 1259169 42407 109287395
Pulmonary haemorrhage 29.25 10.66 93 1259404 16363 109313439
Autoimmune disorder 29.22 10.66 964 1258533 64519 109265283
Nasal polyps 29.19 10.66 67 1259430 13133 109316669
Aphasia 29.15 10.66 484 1259013 58513 109271289
Haematochezia 29.14 10.66 1602 1257895 113922 109215880
Hepatic encephalopathy 29.13 10.66 195 1259302 28061 109301741
Fracture nonunion 29.07 10.66 58 1259439 1476 109328326
Injection site bruising 28.93 10.66 777 1258720 50486 109279316
Hallucination 28.84 10.66 907 1258590 100525 109229277
Bacteraemia 28.78 10.66 326 1259171 42064 109287738
Sleep terror 28.77 10.66 20 1259477 6590 109323212
Blood parathyroid hormone increased 28.73 10.66 110 1259387 4138 109325664
Toxic anterior segment syndrome 28.62 10.66 3 1259494 3451 109326351
Psychomotor hyperactivity 28.60 10.66 126 1259371 20151 109309651
Drug screen positive 28.43 10.66 19 1259478 6391 109323411
Body height decreased 28.42 10.66 212 1259285 10351 109319451
Increased tendency to bruise 28.32 10.66 230 1259267 11528 109318274
Body temperature decreased 28.27 10.66 584 1258913 36351 109293451
Nasal congestion 28.27 10.66 1380 1258117 96902 109232900
Infection reactivation 28.20 10.66 6 1259491 4075 109325727
Palmoplantar keratoderma 28.18 10.66 13 1259484 5374 109324428
Blood pressure diastolic increased 28.14 10.66 333 1259164 18474 109311328
Wheelchair user 28.10 10.66 169 1259328 7673 109322129
Tenosynovitis 27.86 10.66 296 1259201 15987 109313815
Metabolic disorder 27.84 10.66 48 1259449 10462 109319340
Subarachnoid haemorrhage 27.69 10.66 211 1259286 29491 109300311
Viral mutation identified 27.62 10.66 8 1259489 4411 109325391
Joint injury 27.61 10.66 623 1258874 39371 109290431
Drug effective for unapproved indication 27.39 10.66 77 1259420 14090 109315712
Purpura 27.35 10.66 164 1259333 24224 109305578
Dermatitis exfoliative 27.25 10.66 55 1259442 11292 109318510
Lower limb fracture 27.20 10.66 1083 1258414 74265 109255537
Pulmonary congestion 27.01 10.66 224 1259273 30742 109299060
Laryngitis 26.92 10.66 653 1258844 41758 109288044
Drug abuser 26.86 10.66 14 1259483 5395 109324407
Dermatitis acneiform 26.83 10.66 66 1259431 12629 109317173
Enterococcal infection 26.69 10.66 130 1259367 20236 109309566
Hypercholesterolaemia 26.66 10.66 1278 1258219 89559 109240243
Breast cancer stage I 26.45 10.66 27 1259470 7360 109322442
Metastases to lung 26.44 10.66 154 1259343 22909 109306893
Nail disorder 26.40 10.66 855 1258642 57080 109272722
Rotator cuff syndrome 26.31 10.66 300 1259197 16494 109313308
Neck deformity 26.27 10.66 63 1259434 1823 109327979
Blood alkaline phosphatase increased 26.23 10.66 611 1258886 70324 109259478
Bone erosion 26.21 10.66 703 1258794 45668 109284134
Pneumonia bacterial 26.19 10.66 183 1259314 26078 109303724
Tremor 26.19 10.66 1965 1257532 200267 109129535
Shock haemorrhagic 26.14 10.66 192 1259305 27055 109302747
Adverse event 26.11 10.66 1502 1257995 107307 109222495
Klebsiella infection 26.06 10.66 128 1259369 19881 109309921
Accidental exposure to product by child 25.93 10.66 3 1259494 3195 109326607
Limb discomfort 25.93 10.66 629 1258868 40225 109289577
Migraine 25.84 10.66 2281 1257216 169371 109160431
Virologic failure 25.83 10.66 12 1259485 4940 109324862
Systemic mycosis 25.71 10.66 6 1259491 3823 109325979
Hepatitis fulminant 25.63 10.66 36 1259461 8524 109321278
Lethargy 25.58 10.66 841 1258656 92735 109237067
Cerebrovascular accident 25.50 10.66 1749 1257748 179535 109150267
Myocarditis 25.50 10.66 219 1259278 29836 109299966
Fear 25.47 10.66 157 1259340 23036 109306766
Atrioventricular block complete 25.28 10.66 130 1259367 19952 109309850
Epstein-Barr viraemia 25.27 10.66 5 1259492 3574 109326228
Blood pressure increased 25.26 10.66 3336 1256161 255037 109074765
Atrial tachycardia 25.16 10.66 41 1259456 9137 109320665
Vascular stent thrombosis 25.16 10.66 8 1259489 4153 109325649
Product label confusion 25.02 10.66 380 1259117 22297 109307505
Tongue disorder 24.97 10.66 261 1259236 14037 109315765
Dry eye 24.80 10.66 821 1258676 54972 109274830
Myocardial ischaemia 24.67 10.66 190 1259307 26494 109303308
Injection site swelling 24.66 10.66 898 1258599 60892 109268910
Bacterial sepsis 24.64 10.66 51 1259446 10375 109319427
Pancreatitis acute 24.64 10.66 511 1258986 59763 109270039
Arteriospasm coronary 24.62 10.66 41 1259456 9059 109320743
Abortion incomplete 24.62 10.66 3 1259494 3069 109326733
Intraductal proliferative breast lesion 24.61 10.66 81 1259416 2824 109326978
Acute lymphocytic leukaemia recurrent 24.55 10.66 18 1259479 5769 109324033
Hyperuricaemia 24.53 10.66 84 1259413 14447 109315355
Dislocation of vertebra 24.48 10.66 662 1258835 43059 109286743
Catatonia 24.47 10.66 58 1259439 11242 109318560
Visual acuity reduced 24.45 10.66 241 1259256 31932 109297870
Adjustment disorder with depressed mood 24.44 10.66 664 1258833 43219 109286583
Back injury 24.39 10.66 710 1258787 46689 109283113
Sleep disorder 24.35 10.66 2602 1256895 196042 109133760
Relapsing-remitting multiple sclerosis 24.26 10.66 65 1259432 2017 109327785
Meniscus injury 24.24 10.66 162 1259335 7631 109322171
Smear cervix abnormal 24.23 10.66 77 1259420 2635 109327167
Needle fatigue 24.20 10.66 48 1259449 1216 109328586
Reversible cerebral vasoconstriction syndrome 24.13 10.66 12 1259485 4749 109325053
Accidental overdose 24.08 10.66 430 1259067 51404 109278398
Skin cancer 24.07 10.66 309 1259188 17475 109312327
Mitochondrial toxicity 24.06 10.66 4 1259493 3241 109326561
Immune-mediated myositis 24.03 10.66 21 1259476 6165 109323637
Haemorrhage 23.97 10.66 982 1258515 105710 109224092
Linear IgA disease 23.90 10.66 10 1259487 4379 109325423
Cardiomyopathy 23.89 10.66 255 1259242 33270 109296532
Appendicitis 23.88 10.66 208 1259289 28256 109301546
Lumbar vertebral fracture 23.86 10.66 182 1259315 8949 109320853
Pancreatitis 23.85 10.66 848 1258649 92685 109237117
Local anaesthetic systemic toxicity 23.78 10.66 17 1259480 5520 109324282
Herpes zoster 23.73 10.66 1484 1258013 106895 109222907
Alanine aminotransferase increased 23.58 10.66 1787 1257710 181986 109147816
Gastric cancer 23.44 10.66 57 1259440 10951 109318851
Upper limb fracture 23.43 10.66 351 1259146 20537 109309265
Myasthenia gravis 23.42 10.66 146 1259351 21365 109308437
Diverticulum intestinal 23.42 10.66 220 1259277 11499 109318303
Peripheral sensory neuropathy 23.32 10.66 104 1259393 16576 109313226
Immune effector cell-associated neurotoxicity syndrome 23.27 10.66 88 1259409 14694 109315108
Neoplasm progression 23.16 10.66 559 1258938 64036 109265766
Folate deficiency 23.05 10.66 106 1259391 4332 109325470
Ankle fracture 23.00 10.66 335 1259162 19484 109310318
Upper respiratory tract infection 22.94 10.66 1765 1257732 129563 109200239
Viraemia 22.90 10.66 9 1259488 4093 109325709
Tooth infection 22.89 10.66 368 1259129 21848 109307954
Thyroid mass 22.87 10.66 117 1259380 4996 109324806
Hip fracture 22.85 10.66 543 1258954 34608 109295194
Amylase increased 22.78 10.66 70 1259427 12449 109317353
Scoliosis 22.78 10.66 174 1259323 8559 109321243
Oral herpes 22.75 10.66 555 1258942 35525 109294277
Hepatitis B 22.73 10.66 47 1259450 9565 109320237
Hyperlactacidaemia 22.73 10.66 37 1259460 8249 109321553
Angina unstable 22.64 10.66 103 1259394 16329 109313473
Hypomagnesaemia 22.60 10.66 519 1258978 59851 109269951
Intervertebral disc protrusion 22.55 10.66 442 1259055 27256 109302546
Lymphoid tissue hypoplasia 22.53 10.66 55 1259442 1610 109328192
Bradypnoea 22.46 10.66 40 1259457 8609 109321193
Jaw disorder 22.44 10.66 118 1259379 5094 109324708
Diabetes insipidus 22.42 10.66 25 1259472 6545 109323257
Blood iron decreased 22.38 10.66 325 1259172 18889 109310913
Vitamin D increased 22.19 10.66 37 1259460 816 109328986
Irritability 22.08 10.66 397 1259100 47412 109282390
Fungaemia 22.07 10.66 22 1259475 6064 109323738
Central nervous system lupus 21.95 10.66 48 1259449 1305 109328497
Cardiac failure chronic 21.88 10.66 82 1259415 13729 109316073
Gene mutation 21.81 10.66 6 1259491 3423 109326379
Ventricular arrhythmia 21.66 10.66 52 1259445 10035 109319767
Insomnia 21.66 10.66 4535 1254962 356055 108973747
Sexual dysfunction 21.66 10.66 40 1259457 8490 109321312
Injury 21.59 10.66 2321 1257176 174944 109154858
Joint dislocation 21.58 10.66 526 1258971 33664 109296138
Full blood count decreased 21.53 10.66 498 1258999 31601 109298201
Ligament rupture 21.42 10.66 97 1259400 3938 109325864
Cellulitis 21.41 10.66 1690 1257807 124326 109205476
Metastases to bone 21.40 10.66 241 1259256 31131 109298671
Humerus fracture 21.39 10.66 202 1259295 10574 109319228
Left ventricular dysfunction 21.38 10.66 168 1259329 23325 109306477
Pelvic fracture 21.35 10.66 251 1259246 13903 109315899
Immunisation 21.35 10.66 5 1259492 3178 109326624
Maternal exposure during delivery 21.30 10.66 7 1259490 3558 109326244
Blood glucose increased 21.26 10.66 1263 1258234 131233 109198569
Hypoglycaemic coma 21.24 10.66 19 1259478 5514 109324288
Onychomycosis 21.17 10.66 582 1258915 37949 109291853
Capillary leak syndrome 21.17 10.66 15 1259482 4893 109324909
Surgery 21.14 10.66 618 1258879 40665 109289137
Acute lung injury 21.03 10.66 5 1259492 3146 109326656
Thymus hypoplasia 21.02 10.66 54 1259443 1633 109328169
Lower respiratory tract infection viral 21.01 10.66 49 1259448 1392 109328410
Hypercalciuria 20.98 10.66 29 1259468 539 109329263
Ketoacidosis 20.88 10.66 53 1259444 10034 109319768
Wrong product administered 20.87 10.66 60 1259437 10900 109318902
Rash 20.86 10.66 9979 1249518 810985 108518817
Delirium 20.81 10.66 1292 1258205 133733 109196069
Pseudomonal sepsis 20.75 10.66 45 1259452 9001 109320801
Nephrotic syndrome 20.71 10.66 84 1259413 13747 109316055
Upper respiratory tract inflammation 20.71 10.66 12 1259485 4359 109325443
Spondylolisthesis 20.69 10.66 92 1259405 3706 109326096
Aphthous ulcer 20.62 10.66 347 1259150 20789 109309013
Rash morbilliform 20.44 10.66 37 1259460 7914 109321888
Haematocrit decreased 20.42 10.66 935 1258562 65182 109264620
Tonsillar ulcer 20.40 10.66 26 1259471 445 109329357
Drug-induced liver injury 20.26 10.66 1139 1258358 118928 109210874
Limb injury 20.26 10.66 567 1258930 37069 109292733
Oral infection 20.25 10.66 133 1259364 6228 109323574
Liver function test increased 20.23 10.66 1217 1258280 87331 109242471
Dehydration 20.19 10.66 2832 1256665 276679 109053123
Injection site rash 20.19 10.66 377 1259120 23042 109306760
Granulocyte count decreased 20.16 10.66 10 1259487 3964 109325838
Oral pain 20.13 10.66 564 1258933 36880 109292922
Haemorrhage subcutaneous 20.11 10.66 20 1259477 5519 109324283
Product monitoring error 20.10 10.66 172 1259325 8755 109321047
Mean cell volume increased 20.09 10.66 163 1259334 8167 109321635
Alanine aminotransferase abnormal 20.06 10.66 178 1259319 9156 109320646
Renal tubular necrosis 20.05 10.66 236 1259261 30239 109299563
Post procedural infection 20.00 10.66 243 1259254 13566 109316236
Treatment noncompliance 19.95 10.66 656 1258841 72334 109257468
Tibia fracture 19.95 10.66 136 1259361 6449 109323353
Rotator cuff repair 19.93 10.66 64 1259433 2202 109327600
Mucosal inflammation 19.90 10.66 893 1258604 95248 109234554
Right ventricular failure 19.90 10.66 194 1259303 25760 109304042
Euglycaemic diabetic ketoacidosis 19.75 10.66 67 1259430 11556 109318246
Viral haemorrhagic cystitis 19.74 10.66 7 1259490 3392 109326410
Generalised oedema 19.73 10.66 239 1259258 30465 109299337
Sudden death 19.71 10.66 180 1259317 24215 109305587
Epstein-Barr virus infection reactivation 19.65 10.66 11 1259486 4073 109325729
Propofol infusion syndrome 19.63 10.66 3 1259494 2586 109327216
Hepatitis acute 19.60 10.66 129 1259368 18637 109311165
Urinary retention 19.59 10.66 624 1258873 69059 109260743
Hypertransaminasaemia 19.58 10.66 179 1259318 24076 109305726
Parkinsonism 19.57 10.66 160 1259337 22027 109307775
Hypoxic-ischaemic encephalopathy 19.49 10.66 45 1259452 8802 109321000
Hypertonic bladder 19.47 10.66 115 1259382 5187 109324615
Corneal oedema 19.36 10.66 6 1259491 3167 109326635
Cardiac tamponade 19.34 10.66 65 1259432 11242 109318560
Brain death 19.33 10.66 28 1259469 6545 109323257
Musculoskeletal discomfort 19.29 10.66 376 1259121 23162 109306640
Tooth abscess 19.27 10.66 311 1259186 18478 109311324
Frequent bowel movements 19.20 10.66 996 1258501 70394 109259408
Alcohol interaction 19.19 10.66 9 1259488 3685 109326117
Hypercapnia 19.19 10.66 64 1259433 11095 109318707
Depressive symptom 19.18 10.66 42 1259455 8372 109321430
Breast cancer stage III 19.14 10.66 1093 1258404 78024 109251778
Sinus bradycardia 19.14 10.66 229 1259268 29254 109300548
Osteoporotic fracture 19.11 10.66 115 1259382 5222 109324580
Oliguria 19.11 10.66 129 1259368 18528 109311274
Kidney transplant rejection 19.10 10.66 71 1259426 11916 109317886
Rheumatoid nodule 19 10.66 331 1259166 19965 109309837
Disinhibition 18.99 10.66 6 1259491 3128 109326674
Cystic fibrosis 18.94 10.66 105 1259392 4626 109325176
Necrotising fasciitis 18.92 10.66 36 1259461 7555 109322247
Squamous cell carcinoma of skin 18.88 10.66 288 1259209 16915 109312887
Disorganised speech 18.85 10.66 7 1259490 3296 109326506
Peripheral venous disease 18.82 10.66 1154 1258343 82963 109246839
Hypoproteinaemia 18.82 10.66 24 1259473 5921 109323881
Areflexia 18.78 10.66 30 1259467 6739 109323063
Polyomavirus viraemia 18.78 10.66 8 1259489 3466 109326336
Hyperreflexia 18.75 10.66 51 1259446 9434 109320368
Hiatus hernia 18.73 10.66 429 1259068 27177 109302625
Hyperparathyroidism secondary 18.73 10.66 81 1259416 3223 109326579
Prescribed underdose 18.71 10.66 915 1258582 64259 109265543
Parathyroid tumour benign 18.68 10.66 39 1259458 1026 109328776
Device loosening 18.62 10.66 34 1259463 808 109328994
Prostate cancer stage IV 18.60 10.66 3 1259494 2485 109327317
Staphylococcal infection 18.56 10.66 631 1258866 69313 109260489
Pollakiuria 18.55 10.66 646 1258851 43549 109286253
Anaemia postoperative 18.51 10.66 56 1259441 1865 109327937
Pneumomediastinum 18.50 10.66 18 1259479 5018 109324784
Burning sensation 18.49 10.66 965 1258532 68247 109261555
Hepatic cancer 18.49 10.66 65 1259432 11091 109318711
Muscle strain 18.41 10.66 202 1259295 11000 109318802
Limb deformity 18.38 10.66 88 1259409 3658 109326144
Hyperprolactinaemia 18.37 10.66 29 1259468 6546 109323256
Injection site pain 18.37 10.66 2305 1257192 175617 109154185
Mucous stools 18.19 10.66 137 1259360 6710 109323092
Faecal calprotectin increased 18.16 10.66 135 1259362 6584 109323218
Ankylosing spondylitis 18.16 10.66 264 1259233 15348 109314454
Spinal operation 18.10 10.66 198 1259299 10774 109319028
Hepatic cirrhosis 18.09 10.66 943 1258554 66683 109263119
Pulmonary embolism 18.05 10.66 2152 1257345 212322 109117480
Cytomegalovirus colitis 18.02 10.66 33 1259464 7028 109322774
Bacterial infection 18.02 10.66 393 1259104 45643 109284159
Dental implantation 18.02 10.66 31 1259466 702 109329100
Right atrial hypertrophy 18.02 10.66 30 1259467 661 109329141
Dermatitis atopic 17.99 10.66 399 1259098 25142 109304660
Aortic valve stenosis 17.98 10.66 129 1259368 6221 109323581
Neuritis 17.97 10.66 145 1259352 7254 109322548
Pulse absent 17.92 10.66 67 1259430 11225 109318577
Clonus 17.89 10.66 46 1259451 8670 109321132
Lupus-like syndrome 17.81 10.66 599 1258898 40193 109289609
Immune-mediated enterocolitis 17.80 10.66 58 1259439 10127 109319675
Gingival recession 17.75 10.66 48 1259449 1498 109328304
JC polyomavirus test positive 17.74 10.66 63 1259434 2284 109327518
Pneumonia fungal 17.74 10.66 97 1259400 14657 109315145
Fibula fracture 17.71 10.66 101 1259396 4497 109325305
Device related infection 17.68 10.66 330 1259167 39189 109290613
Pupillary reflex impaired 17.67 10.66 12 1259485 4003 109325799
Maternal exposure timing unspecified 17.67 10.66 337 1259160 20676 109309126
Cryptococcosis 17.66 10.66 16 1259481 4615 109325187
Product prescribing issue 17.63 10.66 80 1259417 12692 109317110
Loss of employment 17.60 10.66 8 1259489 3336 109326466
Groin pain 17.59 10.66 260 1259237 15168 109314634
Salivary hypersecretion 17.57 10.66 121 1259376 17300 109312502
Cough 17.55 10.66 5692 1253805 455949 108873853
Osteonecrosis of jaw 17.53 10.66 691 1258806 47326 109282476
Body mass index abnormal 17.48 10.66 35 1259462 893 109328909
Aortic arteriosclerosis 17.41 10.66 196 1259301 10742 109319060
Hypervitaminosis D 17.41 10.66 14 1259483 133 109329669
Retinal haemorrhage 17.38 10.66 53 1259444 9448 109320354
Nephritic syndrome 17.37 10.66 25 1259472 483 109329319
Congestive cardiomyopathy 17.36 10.66 93 1259404 14126 109315676
Anticholinergic syndrome 17.28 10.66 14 1259483 4266 109325536
Diabetes mellitus 17.28 10.66 940 1258557 98441 109231361
Multimorbidity 17.26 10.66 47 1259450 1473 109328329
Lumbar spinal stenosis 17.25 10.66 129 1259368 6304 109323498
Product prescribing error 17.20 10.66 732 1258765 50599 109279203
Red blood cell sedimentation rate 17.20 10.66 110 1259387 5104 109324698
Acquired gene mutation 17.18 10.66 5 1259492 2749 109327053
Acute pulmonary oedema 17.17 10.66 118 1259379 16878 109312924
Pseudomembranous colitis 17.10 10.66 29 1259468 6362 109323440
Hand fracture 17.00 10.66 154 1259343 7968 109321834
Neutropenic colitis 16.99 10.66 42 1259455 8023 109321779
Drug therapy 16.95 10.66 36 1259461 7255 109322547
Hypernatraemia 16.95 10.66 126 1259371 17707 109312095
Edentulous 16.92 10.66 17 1259480 221 109329581
Swollen tongue 16.85 10.66 541 1258956 59821 109269981
Paraesthesia 16.83 10.66 3480 1256017 273041 109056761
Coronary artery stenosis 16.79 10.66 90 1259407 13668 109316134
Fistula 16.74 10.66 256 1259241 15043 109314759
Heart rate irregular 16.71 10.66 510 1258987 33764 109296038
Neck mass 16.71 10.66 103 1259394 4718 109325084
Multiple drug therapy 16.67 10.66 42 1259455 7972 109321830
Skin papilloma 16.67 10.66 135 1259362 6761 109323041
Premature rupture of membranes 16.66 10.66 100 1259397 4537 109325265
Arthropod bite 16.64 10.66 176 1259321 9495 109320307
Parvovirus B19 infection 16.62 10.66 6 1259491 2875 109326927
Nocturia 16.60 10.66 279 1259218 16711 109313091
Inadequate analgesia 16.59 10.66 20 1259477 5057 109324745
Aplasia 16.58 10.66 41 1259456 7832 109321970
Pulmonary toxicity 16.57 10.66 126 1259371 17620 109312182
Isosthenuria 16.55 10.66 13 1259484 119 109329683
Intentional dose omission 16.54 10.66 321 1259176 19759 109310043
Tenosynovitis stenosans 16.50 10.66 83 1259414 3520 109326282
Urinary hesitation 16.45 10.66 100 1259397 4558 109325244
Hyperaesthesia teeth 16.43 10.66 61 1259436 2261 109327541
Fluid retention 16.40 10.66 892 1258605 93415 109236387
Hypertriglyceridaemia 16.39 10.66 112 1259385 16042 109313760
Hypovolaemic shock 16.39 10.66 98 1259399 14485 109315317
Endodontic procedure 16.36 10.66 75 1259422 3061 109326741
Eye infection 16.30 10.66 244 1259253 14274 109315528
Hemiparesis 16.28 10.66 378 1259119 43525 109286277
Complications of transplanted kidney 16.27 10.66 38 1259459 7404 109322398
Ingrowing nail 16.27 10.66 77 1259420 3185 109326617
Tubulointerstitial nephritis 16.26 10.66 482 1259015 53802 109276000
Blepharospasm 16.15 10.66 772 1258725 54079 109275723
Nerve compression 16.14 10.66 196 1259301 10941 109318861
Blood calcium decreased 16.13 10.66 299 1259198 35546 109294256
Skin laceration 16.13 10.66 501 1258996 33252 109296550
Cystitis 16.11 10.66 913 1258584 65123 109264679
Muscle spasticity 16.09 10.66 529 1258968 35386 109294416
Invasive ductal breast carcinoma 16.01 10.66 130 1259367 6516 109323286
Musculoskeletal disorder 15.94 10.66 354 1259143 22310 109307492
Gastrointestinal toxicity 15.89 10.66 69 1259428 11079 109318723
Scleritis 15.86 10.66 111 1259386 5309 109324493
Gingival disorder 15.85 10.66 91 1259406 4062 109325740
Cervical spinal stenosis 15.82 10.66 71 1259426 2871 109326931
Disturbance in attention 15.82 10.66 562 1258935 61433 109268369
Hypopituitarism 15.77 10.66 16 1259481 4374 109325428
Radiation pneumonitis 15.77 10.66 17 1259480 4519 109325283
Nightmare 15.73 10.66 330 1259167 38533 109291269
Breast disorder 15.72 10.66 60 1259437 2254 109327548
Sleep disorder therapy 15.66 10.66 39 1259458 7432 109322370
Hepatic necrosis 15.66 10.66 59 1259438 9863 109319939
Knee operation 15.66 10.66 135 1259362 6887 109322915
Product administration interrupted 15.62 10.66 197 1259300 11095 109318707
Leukocytosis 15.62 10.66 480 1259017 53348 109276454
Vitamin B complex deficiency 15.61 10.66 35 1259462 968 109328834
Dyskinesia 15.61 10.66 456 1259041 50990 109278812
Prescription drug used without a prescription 15.59 10.66 24 1259473 5472 109324330
Intestinal ischaemia 15.53 10.66 114 1259383 16065 109313737
Disturbance in social behaviour 15.42 10.66 21 1259476 5037 109324765
Rib fracture 15.29 10.66 498 1258999 33272 109296530
Cardiopulmonary failure 15.24 10.66 43 1259454 7860 109321942
Genital haemorrhage 15.09 10.66 38 1259459 7214 109322588
Clostridium test positive 15.05 10.66 190 1259307 10703 109319099
Periodontal disease 15.05 10.66 54 1259443 1968 109327834
Osteomalacia 15.05 10.66 46 1259451 1541 109328261
Laryngeal oedema 15.04 10.66 59 1259438 9748 109320054
Malignant mediastinal neoplasm 15.04 10.66 42 1259455 1336 109328466
Acrochordon 15.03 10.66 43 1259454 1387 109328415
Apraxia 15.03 10.66 11 1259486 3529 109326273
Synovial disorder 15.01 10.66 71 1259426 2936 109326866
Foot operation 14.97 10.66 138 1259359 7175 109322627
Incorrect route of product administration 14.95 10.66 587 1258910 63474 109266328
Quadriparesis 14.90 10.66 19 1259478 4688 109325114
Gingival pain 14.86 10.66 257 1259240 15479 109314323
Pharyngitis streptococcal 14.85 10.66 223 1259274 13054 109316748
Vertebral wedging 14.84 10.66 8 1259489 35 109329767
Anaphylactoid reaction 14.81 10.66 35 1259462 6791 109323011
Tumour haemorrhage 14.78 10.66 23 1259474 5222 109324580
Coronary arterial stent insertion 14.78 10.66 28 1259469 5887 109323915
Autonomic nervous system imbalance 14.77 10.66 27 1259470 5753 109324049
Compartment syndrome 14.75 10.66 28 1259469 5882 109323920
Ileal stenosis 14.75 10.66 75 1259422 3195 109326607
Flatulence 14.73 10.66 731 1258766 51418 109278384
Polyhydramnios 14.71 10.66 52 1259445 1881 109327921
Immune-mediated myocarditis 14.68 10.66 11 1259486 3487 109326315
Persecutory delusion 14.68 10.66 31 1259466 6260 109323542
Ligament sprain 14.67 10.66 261 1259236 15807 109313995
Cholecystitis chronic 14.67 10.66 57 1259440 9443 109320359
Accidental poisoning 14.65 10.66 5 1259492 2482 109327320
Ventricular extrasystoles 14.64 10.66 176 1259321 22465 109307337
Rhinorrhoea 14.64 10.66 1359 1258138 101307 109228495
Injection site warmth 14.59 10.66 279 1259218 17126 109312676
Product administered to patient of inappropriate age 14.58 10.66 45 1259452 7991 109321811
Large intestinal stenosis 14.54 10.66 83 1259414 3697 109326105
Nystagmus 14.54 10.66 75 1259422 11502 109318300
Intraductal papillary mucinous neoplasm 14.54 10.66 31 1259466 828 109328974
Analgesic therapy 14.52 10.66 39 1259458 7245 109322557
Full blood count abnormal 14.47 10.66 779 1258718 55273 109274529
Paralysis 14.46 10.66 111 1259386 15489 109314313
Retinitis 14.45 10.66 476 1259021 31851 109297951
Staphylococcal sepsis 14.44 10.66 128 1259369 17326 109312476
Secondary progressive multiple sclerosis 14.43 10.66 45 1259452 1524 109328278
Vital capacity decreased 14.42 10.66 3 1259494 2070 109327732
Patellofemoral pain syndrome 14.41 10.66 24 1259473 529 109329273
Hepatitis C 14.39 10.66 84 1259413 12489 109317313
Paronychia 14.36 10.66 71 1259426 11010 109318792
Cholangitis 14.32 10.66 118 1259379 16217 109313585
Bezoar 14.31 10.66 15 1259482 4039 109325763
Victim of child abuse 14.31 10.66 38 1259459 1173 109328629
Atrioventricular block 14.31 10.66 123 1259374 16754 109313048
Long QT syndrome 14.28 10.66 38 1259459 7080 109322722
Aspiration 14.27 10.66 253 1259244 30280 109299522
Right atrial enlargement 14.26 10.66 23 1259474 493 109329309
Cleft lip and palate 14.26 10.66 28 1259469 704 109329098
Loose body in joint 14.26 10.66 42 1259455 1378 109328424
Hyperammonaemic encephalopathy 14.23 10.66 25 1259472 5409 109324393
Dyspnoea 14.22 10.66 12015 1247482 1094857 108234945
Behaviour disorder 14.19 10.66 59 1259438 9588 109320214
Hypocoagulable state 14.17 10.66 6 1259491 2609 109327193
Back disorder 14.16 10.66 325 1259172 20597 109309205
Blindness 14.06 10.66 311 1259186 36048 109293754
Gastrointestinal infection 14.06 10.66 231 1259266 13774 109316028
Pneumonitis 14.03 10.66 720 1258777 75811 109253991
Arthritis infective 14.03 10.66 181 1259316 10248 109319554
Viral infection 14.02 10.66 740 1258757 52399 109277403
Collagen-vascular disease 14.01 10.66 10 1259487 78 109329724
Flushing 13.98 10.66 1015 1258482 103721 109226081
Aneurysmal bone cyst 13.95 10.66 4 1259493 0 109329802
Lung disorder 13.94 10.66 2294 1257203 177753 109152049
Psychomotor skills impaired 13.91 10.66 38 1259459 7020 109322782
Brain injury 13.89 10.66 93 1259404 13383 109316419
Delayed recovery from anaesthesia 13.86 10.66 4 1259493 2211 109327591
Bone fissure 13.84 10.66 25 1259472 589 109329213
Motor dysfunction 13.84 10.66 195 1259302 24211 109305591
Hepatic cytolysis 13.84 10.66 500 1258997 54553 109275249
Sensory loss 13.80 10.66 167 1259330 21290 109308512
Vaginal infection 13.73 10.66 128 1259369 6676 109323126
Brain abscess 13.71 10.66 36 1259461 6738 109323064
Mite allergy 13.70 10.66 113 1259384 5690 109324112
Prothrombin time prolonged 13.67 10.66 128 1259369 17133 109312669
Milk-alkali syndrome 13.63 10.66 52 1259445 1953 109327849
Extradural haematoma 13.63 10.66 11 1259486 3358 109326444
Spinal pain 13.60 10.66 291 1259206 18224 109311578
Abdominal adhesions 13.58 10.66 88 1259409 4102 109325700
Dry throat 13.57 10.66 163 1259334 9075 109320727
Lipodystrophy acquired 13.57 10.66 19 1259478 4505 109325297
Diplopia 13.56 10.66 368 1259129 41526 109288276
Dysstasia 13.56 10.66 481 1259016 32505 109297297
Epidural lipomatosis 13.55 10.66 53 1259444 2014 109327788
Premature labour 13.55 10.66 162 1259335 9010 109320792
Adrenocorticotropic hormone deficiency 13.55 10.66 4 1259493 2178 109327624
Hypersomnia 13.54 10.66 417 1259080 27644 109302158
Hernia 13.53 10.66 304 1259193 19196 109310606
Hot flush 13.51 10.66 899 1258598 65137 109264665
Renal cyst haemorrhage 13.50 10.66 28 1259469 733 109329069
Granulocytopenia 13.48 10.66 87 1259410 12628 109317174
Gastric ulcer haemorrhage 13.48 10.66 64 1259433 10030 109319772
Acute graft versus host disease in liver 13.46 10.66 5 1259492 2354 109327448
Delusion 13.40 10.66 190 1259307 23565 109306237
Lymphocyte count abnormal 13.39 10.66 59 1259438 2367 109327435
Conjunctival hyperaemia 13.38 10.66 29 1259468 5802 109324000
Bone pain 13.37 10.66 887 1258610 64246 109265556
Intraocular pressure increased 13.35 10.66 71 1259426 10805 109318997
Breast feeding 13.32 10.66 27 1259470 695 109329107
Large intestine perforation 13.30 10.66 123 1259374 16506 109313296
Ankle arthroplasty 13.30 10.66 61 1259436 2490 109327312
Liver transplant rejection 13.27 10.66 15 1259482 3903 109325899
Encephalitis viral 13.22 10.66 9 1259488 2998 109326804
Cold type haemolytic anaemia 13.20 10.66 22 1259475 485 109329317
Hypofibrinogenaemia 13.19 10.66 6 1259491 2501 109327301
Vein disorder 13.18 10.66 119 1259378 6151 109323651
Brain herniation 13.16 10.66 54 1259443 8809 109320993
Metastasis 13.15 10.66 49 1259448 8218 109321584
Mucocutaneous ulceration 13.15 10.66 28 1259469 747 109329055
C-reactive protein 13.14 10.66 445 1259052 29886 109299916
Umbilical hernia 13.13 10.66 130 1259367 6892 109322910
Anaesthetic complication 13.12 10.66 13 1259484 3593 109326209
End stage renal disease 13.11 10.66 169 1259328 21304 109308498
Periprosthetic fracture 13.10 10.66 28 1259469 749 109329053
Constipation 13.10 10.66 3753 1255744 354033 108975769
Coronary artery bypass 13.09 10.66 31 1259466 6011 109323791
Muscle twitching 13.07 10.66 251 1259246 29684 109300118
Colitis ischaemic 13.06 10.66 134 1259363 17616 109312186
Progressive bulbar palsy 13.04 10.66 10 1259487 88 109329714
Engraftment syndrome 13.03 10.66 3 1259494 1929 109327873
Hydrops foetalis 13.00 10.66 28 1259469 753 109329049
Osteomyelitis 12.96 10.66 525 1258972 36075 109293727
Nausea 12.91 10.66 13478 1246019 1222212 108107590
Liver abscess 12.89 10.66 45 1259452 7694 109322108
Pre-eclampsia 12.87 10.66 153 1259344 8497 109321305
Exostosis of jaw 12.85 10.66 37 1259460 1198 109328604
Ingrown hair 12.83 10.66 28 1259469 760 109329042
Intracranial pressure increased 12.81 10.66 69 1259428 10466 109319336
Lung opacity 12.73 10.66 79 1259418 11573 109318229
Femoral hernia incarcerated 12.72 10.66 42 1259455 1467 109328335
Coccydynia 12.69 10.66 60 1259437 2481 109327321
Staphylococcal bacteraemia 12.68 10.66 125 1259372 16563 109313239
Sensitive skin 12.67 10.66 79 1259418 3633 109326169
Gastrointestinal perforation 12.66 10.66 43 1259454 7413 109322389
Hydrocephalus 12.59 10.66 68 1259429 10307 109319495
Pericardial effusion 12.56 10.66 528 1258969 56689 109273113
Ultrasound antenatal screen 12.55 10.66 26 1259471 680 109329122
Blood urea increased 12.52 10.66 505 1258992 54452 109275350
Delusion of grandeur 12.50 10.66 55 1259442 2205 109327597
Eating disorder 12.50 10.66 262 1259235 30596 109299206
Disability 12.49 10.66 441 1259056 29782 109300020
Pulmonary arterial hypertension 12.47 10.66 279 1259218 32289 109297513
Leukoencephalopathy 12.45 10.66 58 1259439 9137 109320665
Sickle cell anaemia 12.38 10.66 28 1259469 779 109329023
Dysphoria 12.38 10.66 35 1259462 6393 109323409
Wrong patient received product 12.37 10.66 37 1259460 6637 109323165
Syringe issue 12.36 10.66 61 1259436 9464 109320338
Postoperative renal failure 12.36 10.66 13 1259484 179 109329623
Spinal disorder 12.36 10.66 195 1259302 11533 109318269
SARS-CoV-2 antibody test negative 12.33 10.66 19 1259478 391 109329411
Intestinal stenosis 12.33 10.66 94 1259403 4621 109325181
White matter lesion 12.30 10.66 63 1259434 2691 109327111
Fistula discharge 12.29 10.66 44 1259453 1602 109328200
Hypophosphatasia 12.25 10.66 11 1259486 123 109329679
Cartilage injury 12.17 10.66 44 1259453 1610 109328192
Homicidal ideation 12.16 10.66 14 1259483 3613 109326189
Inflammatory marker increased 12.15 10.66 232 1259265 14237 109315565
Oesophageal carcinoma 12.15 10.66 79 1259418 11445 109318357
Prostate cancer stage II 12.13 10.66 5 1259492 2210 109327592
Pemphigoid 12.06 10.66 155 1259342 19552 109310250
Joint noise 12.06 10.66 100 1259397 5043 109324759
Hungry bone syndrome 12.06 10.66 17 1259480 322 109329480
Varicella zoster virus infection 12.03 10.66 35 1259462 6333 109323469
Electric shock 12.01 10.66 3 1259494 1825 109327977
Wheezing 11.95 10.66 3174 1256323 252056 109077746
Hostility 11.95 10.66 8 1259489 2688 109327114
Maternal exposure during breast feeding 11.94 10.66 86 1259411 4152 109325650
Eustachian tube obstruction 11.94 10.66 9 1259488 77 109329725
Pancreatic carcinoma 11.90 10.66 110 1259387 14762 109315040
Activated partial thromboplastin time prolonged 11.89 10.66 181 1259316 22187 109307615
Hypothalamo-pituitary disorder 11.88 10.66 9 1259488 2837 109326965
Antinuclear antibody positive 11.86 10.66 158 1259339 9010 109320792
Electrocardiogram ST segment depression 11.85 10.66 28 1259469 5433 109324369
Facial paralysis 11.85 10.66 199 1259298 24015 109305787
Plasma cell myeloma refractory 11.83 10.66 4 1259493 1997 109327805
Atrophic vulvovaginitis 11.83 10.66 39 1259458 1361 109328441
Hypoacusis 11.83 10.66 502 1258995 34689 109295113
CSF immunoglobulin increased 11.81 10.66 7 1259490 38 109329764
Cerebral toxoplasmosis 11.81 10.66 11 1259486 3131 109326671
B-cell lymphoma 11.75 10.66 129 1259368 7025 109322777
Vertebral osteophyte 11.70 10.66 22 1259475 535 109329267
Inflammatory bowel disease 11.68 10.66 130 1259367 7104 109322698
Uterine disorder 11.67 10.66 55 1259442 2271 109327531
Cerebellar haemorrhage 11.66 10.66 12 1259485 3259 109326543
Precancerous skin lesion 11.62 10.66 43 1259454 1591 109328211
Cataract 11.61 10.66 1054 1258443 78431 109251371
Urge incontinence 11.58 10.66 39 1259458 1376 109328426
Pulmonary vasculitis 11.58 10.66 120 1259377 6440 109323362
Nail operation 11.57 10.66 44 1259453 1650 109328152
Skin ulcer 11.55 10.66 858 1258639 62787 109267015
Fracture displacement 11.55 10.66 40 1259457 1432 109328370
Blood 25-hydroxycholecalciferol decreased 11.53 10.66 20 1259477 456 109329346
Appendix disorder 11.53 10.66 47 1259450 1821 109327981
Injection site urticaria 11.52 10.66 267 1259230 16948 109312854
Rectocele 11.51 10.66 27 1259470 770 109329032
Post procedural haemorrhage 11.45 10.66 117 1259380 15395 109314407
Streptobacillus infection 11.45 10.66 5 1259492 12 109329790
Sinus headache 11.44 10.66 112 1259385 5920 109323882
Albumin globulin ratio increased 11.41 10.66 10 1259487 108 109329694
Multi-organ disorder 11.39 10.66 13 1259484 3368 109326434
Lipase increased 11.38 10.66 147 1259350 18525 109311277
Depression 11.36 10.66 3904 1255593 313431 109016371
Subacute cutaneous lupus erythematosus 11.33 10.66 25 1259472 4969 109324833
Menopause 11.30 10.66 58 1259439 2480 109327322
Hepatic cyst 11.29 10.66 137 1259360 7646 109322156
Device malfunction 11.25 10.66 214 1259283 25344 109304458
Animal bite 11.21 10.66 66 1259431 2973 109326829
Hyperhomocysteinaemia 11.21 10.66 24 1259473 643 109329159
Trisomy 18 11.20 10.66 23 1259474 598 109329204
Goitre 11.19 10.66 114 1259383 6090 109323712
Myelodysplastic syndrome 11.19 10.66 333 1259164 37151 109292651
Ischaemic cardiomyopathy 11.17 10.66 50 1259447 7961 109321841
Muscle rupture 11.16 10.66 88 1259409 4372 109325430
Renal tubular atrophy 11.14 10.66 6 1259491 2270 109327532
Pregnancy with contraceptive device 11.14 10.66 17 1259480 3890 109325912
Aplastic anaemia 11.14 10.66 359 1259138 23949 109305853
Cold sweat 11.13 10.66 180 1259317 21851 109307951
Fibroadenoma of breast 11.09 10.66 25 1259472 694 109329108
Secondary adrenocortical insufficiency 11.07 10.66 21 1259476 4413 109325389
Epicondylitis 11.05 10.66 58 1259439 2502 109327300
Differentiation syndrome 11.04 10.66 11 1259486 3033 109326769
Spinal compression fracture 11.02 10.66 281 1259216 18111 109311691
Respiratory symptom 11.01 10.66 235 1259262 14710 109315092
Rectal tenesmus 11.00 10.66 53 1259444 2209 109327593
Enzyme level decreased 10.92 10.66 5 1259492 14 109329788
Clostridium difficile colitis 10.91 10.66 398 1259099 43380 109286422
Breast abscess 10.90 10.66 44 1259453 1697 109328105
Laryngospasm 10.89 10.66 23 1259474 4645 109325157
Therapy interrupted 10.88 10.66 460 1259037 49362 109280440
Vanishing bile duct syndrome 10.87 10.66 12 1259485 3156 109326646
Substance-induced psychotic disorder 10.85 10.66 29 1259468 5395 109324407
Rash pruritic 10.84 10.66 1276 1258221 96793 109233009
Lip swelling 10.82 10.66 469 1259028 50198 109279604
Oral mucosal blistering 10.80 10.66 138 1259359 7796 109322006
Onychoclasis 10.77 10.66 128 1259369 7109 109322693
Drug clearance decreased 10.76 10.66 19 1259478 4103 109325699
Cervical incompetence 10.75 10.66 21 1259476 526 109329276
Femoral neck fracture 10.73 10.66 202 1259295 12365 109317437
Iron metabolism disorder 10.71 10.66 10 1259487 118 109329684
Injection site hypersensitivity 10.68 10.66 56 1259441 2415 109327387

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 17.57 15.87 3 2186 1404 110360

Pharmacologic Action:

SourceCodeDescription
ATC A11CC05 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC A11CC55 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC M05BB03 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB05 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB07 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB08 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB09 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BX53 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Other drugs affecting bone structure and mineralization
FDA CS M0022797 Vitamin D
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients
MeSH PA D050071 Bone Density Conservation Agents
FDA EPC N0000175952 Vitamin D
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35821 anticholesteremic drug
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50646 bone density conservation agent
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:53784 antispasmodic drug
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:77715 nasal decongestant
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:176497 geroprotector

Related Drugs by ATC class:

A11CC Vitamin D and analogues 5 drugs
alfacalcidolcalcifediolcalcitrioldihydrotachysterolergocalciferol
M05BB Bisphosphonates, combinations 6 drugs
alendronic acidalfacalcidoletidronic acidibandronic acidrisedronic acidzoledronic acid
M05BX Other drugs affecting bone structure and mineralization 8 drugs
aluminium chlorohydrateburosumabdenosumabipriflavonemenatetrenoneromosozumabstrontium ranelatevosoritide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteomalacia indication 4598005 DOID:10573
Hypocalcemia indication 5291005
Vitamin D deficiency indication 34713006
Hypoparathyroidism indication 36976004 DOID:11199
Rickets indication 41345002 DOID:10609
Osteoporosis indication 64859006 DOID:11476
Vitamin deficiency indication 85670002
Postmenopausal osteoporosis indication 102447009
Prevention of dental caries indication 426482000
Glucocorticoid Induced Osteoporosis indication
Hypogonadal Osteoporosis in Males indication
Vitamin D Dependent Rickets indication
Renal osteodystrophy off-label use 16726004 DOID:13068
Anticonvulsant-induced Osteomalacia off-label use
Gastritis contraindication 4556007 DOID:4029
Poisoning by digitalis glycoside contraindication 12876009
Constipation contraindication 14760008 DOID:2089
Esophagitis contraindication 16761005 DOID:11963
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Dental fluorosis contraindication 30265004
Ulcer of esophagus contraindication 30811009
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Atrial fibrillation contraindication 49436004 DOID:0060224
Vitamin E deficiency contraindication 54137008
Hyperlipidemia contraindication 55822004 DOID:1168
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Stricture of esophagus contraindication 63305008
Hypervitaminosis A contraindication 64559002 DOID:9972
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Fracture of femur contraindication 71620000
Hypercalciuria contraindication 71938000
Duodenitis contraindication 72007001 DOID:8643
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Neoplasm of endometrium contraindication 123844007 DOID:1380
Neoplasm of prostate contraindication 126906006 DOID:10283
Hb SS disease contraindication 127040003 DOID:10923
Bed-ridden contraindication 160685001
Acute peptic ulcer contraindication 196682000
Osteolysis contraindication 203522001
Disease of liver contraindication 235856003 DOID:409
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Malignant tumor of cervix contraindication 363354003 DOID:4362
Hemochromatosis contraindication 399187006 DOID:2352
Central nervous system depression contraindication 418072004
Aseptic necrosis of bone of jaw contraindication 441809006
Carcinoma of female breast contraindication 447782002
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication
Malabsorption States contraindication
High Grade Dysplasia associated with Barrett's Esophagus contraindication
Esophageal Obstruction contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML MULTIPLE VITAMINS INJECTION ADULT APOTEX A210672 April 9, 2026 RX SOLUTION INTRAVENOUS Dec. 1, 2026 COMPETITIVE GENERIC THERAPY
80MG/VIAL;0.02MG/VIAL;400 IU/VIAL;0.001MG/VIAL;5MG/VIAL;0.14MG/VIAL;17MG/VIAL;1MG/VIAL;1.4MG/VIAL;1.2MG/VIAL;7 IU/VIAL;2,300 IU/VIAL;0.2MG/VIAL MULTIPLE VITAMINS INJECTION PEDIATRIC APOTEX A210671 April 21, 2026 RX INJECTABLE INTRAVENOUS Dec. 21, 2026 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST EC50 9.68 CHEMBL CHEMBL
Glycine receptor subunit alpha-1 Ion channel EC50 6.40 CHEMBL
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Enzyme WOMBAT-PK
Vitamin D 25-hydroxylase Enzyme WOMBAT-PK
Sterol 26-hydroxylase, mitochondrial Enzyme WOMBAT-PK
Vitamin D3 receptor Nuclear hormone receptor EC50 6.05 CHEMBL

External reference:

IDSource
D00188 KEGG_DRUG
4017667 VANDF
C0008318 UMLSCUI
CHEBI:28940 CHEBI
VD3 PDB_CHEM_ID
CHEMBL1042 ChEMBL_ID
DB00169 DRUGBANK_ID
5280795 PUBCHEM_CID
1244014 RXNORM
15676 MMSL
199274 MMSL
4434 MMSL
4868 MMSL
4871 MMSL
d03129 MMSL
001014 NDDF
108943009 SNOMEDCT_US
18414002 SNOMEDCT_US
D002762 MESH_DESCRIPTOR_UI
2747 IUPHAR_LIGAND_ID
1497 INN_ID
1C6V77QF41 UNII
1C6V77QF41 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 400 [iU] ORAL Unapproved drug other 12 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 400 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 400 [iU] ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 400 [iU] ORAL Unapproved drug other 11 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 400 [iU] ORAL UNAPPROVED DRUG OTHER 14 sections
VitafolUltra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 25 ug ORAL unapproved drug other 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 400 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite OneCaplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 25 ug ORAL unapproved drug other 14 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 25 mg ORAL unapproved drug other 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 400 [iU] ORAL UNAPPROVED DRUG OTHER 4 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 400 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 2000 [iU] ORAL Unapproved drug other 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 400 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 400 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 400 [iU] ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 400 [iU] ORAL unapproved drug other 16 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 400 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 400 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 14 15370-102 LIQUID 400 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-103 TABLET, CHEWABLE 400 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-104 TABLET, CHEWABLE 400 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-105 TABLET, CHEWABLE 400 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
TriStart DHA HUMAN PRESCRIPTION DRUG LABEL 15 15370-250 CAPSULE, LIQUID FILLED 1000 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 17856-0668 TABLET, FILM COATED 400 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
C-Nate DHA HUMAN PRESCRIPTION DRUG LABEL 13 23359-105 CAPSULE, GELATIN COATED 400 [iU] ORAL unapproved drug other 15 sections
Prenatal Plus Vitamins HUMAN PRESCRIPTION DRUG LABEL 15 39328-106 TABLET 10 ug ORAL UNAPPROVED DRUG OTHER 7 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 18 42192-320 TABLET, FILM COATED 400 [iU] ORAL unapproved drug other 10 sections
PNV-DHA HUMAN PRESCRIPTION DRUG LABEL 10 42192-321 CAPSULE, GELATIN COATED 200 [iU] ORAL unapproved drug other 11 sections
PNV-DHA HUMAN PRESCRIPTION DRUG LABEL 8 42192-323 CAPSULE, GELATIN COATED 400 [iU] ORAL unapproved drug other 11 sections
PNV-Omega HUMAN PRESCRIPTION DRUG LABEL 13 42192-332 CAPSULE, GELATIN COATED 200 [iU] ORAL unapproved drug other 12 sections