All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

denosumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
human origin	4965	615258-40-7

Description:

Molecule	Description
Synonyms: denosumab prolia AMG 162 AMG162	A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
0.33	mg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
May 26, 2010	EMA	Amgen Europe B.V.
June 1, 2010	FDA	AMGEN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	44255.26	11.30	27558	192774	646904	62621786
Osteonecrosis of jaw	11079.95	11.30	4271	216061	30852	63237838
Death	5901.30	11.30	6846	213486	367535	62901155
Spinal fracture	2579.15	11.30	1262	219070	17009	63251681
Bone pain	2079.58	11.30	1634	218698	53007	63215683
Hypocalcaemia	1917.46	11.30	1257	219075	30456	63238234
Tooth disorder	1825.14	11.30	1166	219166	26991	63241699
Atypical femur fracture	1519.68	11.30	605	219727	4767	63263923
Pain in jaw	1472.48	11.30	1215	219117	42281	63226409
Drug ineffective	1379.74	11.30	980	219352	1043785	62224905
Tooth extraction	1362.01	11.30	680	219652	9584	63259106
Back pain	1223.28	11.30	2775	217557	261370	63007320
Pain in extremity	1052.19	11.30	3019	217313	328467	62940223
Myalgia	1002.89	11.30	1812	218520	144717	63123973
Occupational exposure to product	893.50	11.30	318	220014	1760	63266930
Accidental exposure to product	866.07	11.30	736	219596	26669	63242021
Bone density abnormal	848.72	11.30	350	219982	3048	63265642
Fracture	832.62	11.30	626	219706	18958	63249732
Thoracic vertebral fracture	750.55	11.30	351	219981	4241	63264449
Bone density decreased	739.29	11.30	519	219813	14093	63254597
Tooth fracture	734.28	11.30	466	219866	10644	63258046
Rebound effect	678.62	11.30	326	220006	4200	63264490
Metastases to bone	667.17	11.30	566	219766	20453	63248237
Lumbar vertebral fracture	646.59	11.30	342	219990	5468	63263222
Maternal exposure during pregnancy	622.01	11.30	35	220297	220027	63048663
Toothache	617.60	11.30	521	219811	18678	63250012
Pemphigus	591.16	11.30	9	220323	183717	63084973
Arthralgia	586.29	11.30	3674	216658	566036	62702654
Spinal compression fracture	579.39	11.30	444	219888	13839	63254851
Toxicity to various agents	557.52	11.30	94	220238	247156	63021534
Femur fracture	552.83	11.30	703	219629	41053	63227637
Infusion related reaction	545.58	11.30	97	220235	245424	63023266
Drug intolerance	538.95	11.30	199	220133	308462	62960228
Blood parathyroid hormone increased	536.39	11.30	245	220087	2793	63265897
Hip fracture	530.99	11.30	581	219751	28893	63239797
Synovitis	524.28	11.30	31	220301	186887	63081803
Dental implantation	519.89	11.30	164	220168	578	63268112
Dental care	515.41	11.30	179	220153	910	63267780
Contraindicated product administered	512.81	11.30	73	220259	217575	63051115
Exposure during pregnancy	512.05	11.30	5	220327	155542	63113148
Exposed bone in jaw	507.36	11.30	233	220099	2692	63265998
Jaw disorder	501.25	11.30	281	220051	5068	63263622
Systemic lupus erythematosus	492.36	11.30	70	220262	208848	63059842
Tooth loss	489.36	11.30	302	220030	6554	63262136
Groin pain	480.61	11.30	347	219985	9856	63258834
Treatment failure	477.79	11.30	63	220269	198980	63069710
Completed suicide	473.51	11.30	6	220326	145667	63123023
Pathological fracture	470.80	11.30	324	220008	8510	63260180
Condition aggravated	441.91	11.30	447	219885	401770	62866920
Product storage error	440.65	11.30	386	219946	14570	63254120
Product use issue	433.29	11.30	115	220217	220405	63048285
Glossodynia	412.06	11.30	64	220268	178812	63089878
Bone loss	398.36	11.30	201	220131	2898	63265792
Breast cancer metastatic	390.34	11.30	328	220004	11690	63257000
Hand deformity	383.75	11.30	50	220282	159407	63109283
Therapeutic product effect decreased	377.11	11.30	102	220230	193085	63075605
Joint swelling	366.76	11.30	358	219974	327308	62941382
Drug hypersensitivity	363.55	11.30	326	220006	310361	62958329
Terminal state	356.22	11.30	169	220163	2113	63266577
Exostosis of jaw	346.61	11.30	140	220192	1149	63267541
Loose tooth	344.64	11.30	188	220144	3206	63265484
Hepatic enzyme increased	342.00	11.30	137	220195	202191	63066499
Pericarditis	334.72	11.30	34	220298	131545	63137145
Musculoskeletal pain	330.51	11.30	880	219452	91397	63177293
Drug interaction	329.74	11.30	193	220139	228938	63039752
Metastases to liver	327.15	11.30	407	219925	23232	63245458
Wound	317.10	11.30	87	220245	163176	63105514
Abdominal discomfort	309.33	11.30	396	219936	320489	62948201
Helicobacter infection	284.66	11.30	8	220324	92777	63175913
Product use in unapproved indication	283.97	11.30	133	220199	178947	63089743
Dental caries	281.61	11.30	260	220072	10519	63258171
Neoplasm progression	277.81	11.30	473	219859	35955	63232735
Osteomyelitis	272.54	11.30	391	219941	25629	63243061
Blood calcium decreased	271.98	11.30	394	219938	26057	63242633
Rheumatoid factor positive	271.94	11.30	4	220328	84402	63184288
Duodenal ulcer perforation	269.48	11.30	7	220325	87202	63181488
Acute kidney injury	266.51	11.30	313	220019	263102	63005588
Swelling	265.16	11.30	340	219992	275038	62993652
Atypical fracture	260.88	11.30	94	220238	542	63268148
Hypotension	251.83	11.30	347	219985	272257	62996433
Hospitalisation	251.46	11.30	757	219575	84324	63184366
Foot fracture	251.42	11.30	360	219972	23554	63245136
Incorrect route of product administration	245.34	11.30	383	219949	27069	63241621
Intentional overdose	241.13	11.30	3	220329	74149	63194541
Intercepted product administration error	239.58	11.30	78	220254	312	63268378
Confusional state	235.74	11.30	284	220048	236096	63032594
Overdose	235.60	11.30	55	220277	115023	63153667
Drug abuse	235.52	11.30	3	220329	72515	63196175
Vomiting	235.40	11.30	1071	219261	558546	62710144
Compression fracture	232.45	11.30	187	220145	6261	63262429
Malignant neoplasm progression	223.49	11.30	710	219622	81411	63187279
Blood calcium increased	220.31	11.30	213	220119	9137	63259553
Bone disorder	219.74	11.30	318	220014	21008	63247682
Investigation	214.83	11.30	107	220225	1498	63267192
Endodontic procedure	210.59	11.30	134	220198	3073	63265617
Osteonecrosis	207.84	11.30	334	219998	24196	63244494
Intentional product use issue	207.34	11.30	92	220240	127800	63140890
Rheumatoid arthritis	205.70	11.30	353	219979	253466	63015224
Folliculitis	205.45	11.30	9	220323	70308	63198382
Psoriatic arthropathy	201.24	11.30	37	220295	91483	63177207
Somnolence	194.19	11.30	200	220132	178485	63090205
Multiple fractures	189.41	11.30	189	220143	8429	63260261
Weight increased	188.18	11.30	389	219943	260403	63008287
Hypersensitivity	188.11	11.30	465	219867	292220	62976470
Jaw operation	186.80	11.30	80	220252	772	63267918
Muscle injury	185.67	11.30	10	220322	65335	63203355
Dyspnoea	181.77	11.30	1448	218884	659865	62608825
Wrist fracture	181.71	11.30	230	220102	13357	63255333
Eczema	178.22	11.30	365	219967	31926	63236764
Muscle spasms	175.23	11.30	1032	219300	155118	63113572
Gingival disorder	174.92	11.30	124	220208	3418	63265272
Pelvic fracture	173.85	11.30	223	220109	13125	63255565
Tooth abscess	170.21	11.30	234	220098	14735	63253955
Temporomandibular joint syndrome	167.75	11.30	128	220204	3961	63264729
Blood calcium abnormal	165.20	11.30	83	220249	1185	63267505
Suicide attempt	165.07	11.30	12	220320	60906	63207784
Arthropathy	161.22	11.30	360	219972	234432	63034258
Tooth infection	155.93	11.30	247	220085	17673	63251017
Gingival pain	155.90	11.30	166	220166	7996	63260694
Headache	155.79	11.30	1427	218905	631814	62636876
Sinusitis	153.60	11.30	350	219982	226303	63042387
Fall	152.35	11.30	2052	218280	390282	62878408
Dental operation	152.33	11.30	80	220252	1259	63267431
Metastases to lung	152.08	11.30	204	220128	12546	63256144
Breast cancer	151.95	11.30	440	219892	47943	63220747
Spinal pain	150.31	11.30	206	220126	12933	63255757
Discomfort	148.53	11.30	219	220113	167155	63101535
Stress fracture	146.90	11.30	159	220173	7804	63260886
Artificial crown procedure	146.80	11.30	52	220280	283	63268407
Lower respiratory tract infection	146.10	11.30	146	220186	132161	63136529
Liver injury	145.46	11.30	19	220313	60501	63208189
Bradycardia	142.14	11.30	39	220293	73188	63195502
Seizure	141.21	11.30	151	220181	132483	63136207
Gingivitis	141.17	11.30	160	220172	8269	63260421
Pyrexia	140.46	11.30	1006	219326	469472	62799218
Gingival recession	139.98	11.30	78	220254	1389	63267301
Cystitis	138.36	11.30	463	219869	54528	63214162
Bedridden	138.26	11.30	181	220151	10870	63257820
Type 2 diabetes mellitus	137.89	11.30	27	220305	63841	63204849
Hyperaesthesia teeth	134.63	11.30	82	220250	1736	63266954
Irritable bowel syndrome	133.99	11.30	59	220273	82353	63186337
Cardiac arrest	132.91	11.30	78	220254	92467	63176223
Tetany	132.36	11.30	84	220248	1917	63266773
Nausea	132.19	11.30	2130	218202	852341	62416349
Gingival swelling	132.08	11.30	115	220217	4303	63264387
Rib fracture	131.33	11.30	261	220071	22336	63246354
Abscess jaw	129.58	11.30	73	220259	1329	63267361
Tumour marker increased	129.25	11.30	119	220213	4796	63263894
Abdominal pain	128.83	11.30	552	219780	292904	62975786
Abortion spontaneous	128.73	11.30	9	220323	47186	63221504
Osteonecrosis of external auditory canal	127.36	11.30	37	220295	90	63268600
Pneumonia	126.65	11.30	997	219335	455770	62812920
Depressed level of consciousness	126.37	11.30	30	220302	62048	63206642
Tachycardia	126.35	11.30	134	220198	118022	63150668
Coma	125.45	11.30	34	220298	64330	63204360
C-reactive protein abnormal	125.12	11.30	9	220323	46087	63222603
Wheezing	124.47	11.30	90	220242	95505	63173185
Suicidal ideation	123.51	11.30	32	220300	62389	63206301
Osteitis	122.39	11.30	97	220235	3177	63265513
Periodontitis	121.63	11.30	97	220235	3206	63265484
Mobility decreased	121.51	11.30	778	219554	120381	63148309
Lactic acidosis	114.90	11.30	4	220328	38283	63230407
Dental restoration failure	112.37	11.30	59	220273	928	63267762
Cardio-respiratory arrest	110.76	11.30	35	220297	59924	63208766
Infection	110.06	11.30	416	219916	228757	63039933
Body height decreased	107.81	11.30	153	220179	9925	63258765
Osteoporotic fracture	106.96	11.30	95	220237	3651	63265039
Carbohydrate antigen 15-3 increased	106.43	11.30	65	220267	1383	63267307
Multiple sclerosis relapse	105.70	11.30	20	220312	48458	63220232
C-telopeptide increased	104.40	11.30	24	220308	9	63268681
Metastases to lymph nodes	104.21	11.30	135	220197	8023	63260667
Metastases to spine	104.10	11.30	88	220244	3161	63265529
Febrile neutropenia	102.14	11.30	158	220174	118291	63150399
Musculoskeletal discomfort	101.39	11.30	205	220127	17762	63250928
Oxygen saturation decreased	100.96	11.30	95	220237	88490	63180200
Blister	99.24	11.30	187	220145	129627	63139063
Hypercalcaemia	99.18	11.30	268	220064	28054	63240636
Hyponatraemia	98.67	11.30	147	220185	111753	63156937
Mastication disorder	97.75	11.30	71	220261	2035	63266655
Influenza like illness	97.61	11.30	475	219857	66349	63202341
Dermatitis	97.50	11.30	195	220137	16763	63251927
Upper limb fracture	96.03	11.30	207	220125	18761	63249929
Musculoskeletal stiffness	96.02	11.30	324	220008	184294	63084396
Vitamin D decreased	95.85	11.30	146	220186	10096	63258594
Agitation	93.69	11.30	45	220287	59712	63208978
Sequestrectomy	92.97	11.30	49	220283	777	63267913
Inappropriate schedule of product administration	92.44	11.30	648	219684	103317	63165373
Nasopharyngitis	88.77	11.30	518	219814	253739	63014951
Anaphylactic reaction	87.66	11.30	61	220271	66039	63202651
Dental cleaning	87.50	11.30	22	220310	22	63268668
PIK3CA-activated mutation	86.82	11.30	51	220281	1008	63267682
Prescribed overdose	86.35	11.30	9	220323	34144	63234546
Serotonin syndrome	86.05	11.30	3	220329	28679	63240011
International normalised ratio increased	85.93	11.30	27	220305	46398	63222292
Rash pruritic	85.86	11.30	423	219909	59376	63209314
Lower limb fracture	85.62	11.30	230	220102	23991	63244699
Metabolic acidosis	85.61	11.30	25	220307	45044	63223646
Asthma	85.51	11.30	198	220134	127363	63141327
Oedema	85.33	11.30	129	220203	97493	63171197
Unresponsive to stimuli	85.27	11.30	9	220323	33807	63234883
Hyperparathyroidism	85.10	11.30	73	220259	2676	63266014
Neoplasm malignant	84.70	11.30	262	220070	29599	63239091
Hypoglycaemia	84.31	11.30	52	220280	60013	63208677
Respiratory failure	83.92	11.30	140	220192	101718	63166972
Peripheral swelling	82.44	11.30	562	219770	265380	63003310
No adverse event	82.34	11.30	21	220311	41384	63227306
Anxiety	82.04	11.30	432	219900	217109	63051581
Metastases to central nervous system	81.79	11.30	156	220176	12949	63255741
Injury	80.63	11.30	81	220251	73166	63195524
Encephalopathy	79.92	11.30	18	220314	38602	63230088
Hypoxia	79.53	11.30	55	220277	59737	63208953
Fractured sacrum	78.10	11.30	61	220271	1955	63266735
Femoral neck fracture	77.65	11.30	120	220212	8403	63260287
Intentional self-injury	75.99	11.30	3	220329	25684	63243006
Migraine	75.41	11.30	153	220179	103193	63165497
Foetal exposure during pregnancy	74.52	11.30	11	220321	31951	63236739
Respiratory arrest	74.37	11.30	12	220320	32633	63236057
Premature delivery	73.99	11.30	9	220323	30272	63238418
Tooth erosion	73.74	11.30	35	220297	438	63268252
Immobile	72.27	11.30	96	220236	5847	63262843
Dental necrosis	71.99	11.30	25	220307	127	63268563
Multiple organ dysfunction syndrome	71.84	11.30	55	220277	56697	63211993
Joint noise	71.23	11.30	82	220250	4310	63264380
Chest discomfort	71.07	11.30	174	220158	109795	63158895
Dry skin	70.99	11.30	387	219945	56500	63212190
Incorrect dose administered	69.88	11.30	63	220269	59905	63208785
Gingival abscess	69.68	11.30	41	220291	813	63267877
Syncope	69.55	11.30	194	220138	117191	63151499
Dehydration	68.89	11.30	338	219994	173016	63095674
Hypophosphataemia	67.63	11.30	133	220199	11293	63257397
Psoriasis	66.68	11.30	125	220207	86832	63181858
Chest pain	66.59	11.30	457	219875	215502	63053188
Delirium	66.54	11.30	47	220285	50494	63218196
Gastrointestinal haemorrhage	66.47	11.30	112	220220	81064	63187626
Jaw fistula	66.35	11.30	19	220313	43	63268647
Oral pain	66.10	11.30	233	220099	28161	63240529
Blood pressure decreased	65.91	11.30	77	220255	64945	63203745
Blood parathyroid hormone abnormal	65.15	11.30	26	220306	206	63268484
C-reactive protein increased	65.09	11.30	145	220187	94562	63174128
Tooth resorption	63.39	11.30	18	220314	39	63268651
Product quality issue	62.65	11.30	23	220309	35842	63232848
Vitamin D abnormal	62.24	11.30	23	220309	144	63268546
Therapeutic response decreased	62.21	11.30	73	220259	61452	63207238
Drug withdrawal syndrome	61.94	11.30	10	220322	27184	63241506
Mental status changes	61.79	11.30	30	220302	39569	63229121
Pulpitis dental	61.49	11.30	39	220293	889	63267801
Loss of consciousness	60.90	11.30	208	220124	117913	63150777
Circumstance or information capable of leading to medication error	60.66	11.30	71	220261	3799	63264891
Sedation	59.66	11.30	30	220302	38779	63229911
Metastases to skin	59.45	11.30	48	220284	1615	63267075
Red blood cell sedimentation rate increased	59.10	11.30	40	220292	43942	63224748
Blood phosphorus decreased	58.94	11.30	75	220257	4378	63264312
Spinal deformity	58.66	11.30	40	220292	1034	63267656
Toxic epidermal necrolysis	58.42	11.30	9	220323	25325	63243365
Sleep disorder due to general medical condition, insomnia type	58.32	11.30	57	220275	52160	63216530
Humerus fracture	57.96	11.30	108	220224	8808	63259882
Alanine aminotransferase increased	57.48	11.30	177	220155	103593	63165097
Drug level increased	57.46	11.30	6	220326	22730	63245960
Psychotic disorder	57.36	11.30	10	220322	25702	63242988
Injection site erythema	55.81	11.30	129	220203	83045	63185645
Traumatic fracture	55.48	11.30	33	220299	668	63268022
Hallucination	55.47	11.30	65	220267	54752	63213938
Tibia fracture	55.16	11.30	78	220254	5042	63263648
Hyperkalaemia	55.14	11.30	64	220268	54139	63214551
Sinus tachycardia	55.11	11.30	9	220323	24259	63244431
Living in residential institution	55.07	11.30	30	220302	510	63268180
Emotional distress	54.99	11.30	22	220310	32527	63236163
Flushing	54.91	11.30	111	220221	74976	63193714
Muscle spasticity	54.44	11.30	6	220326	21788	63246902
Heart rate decreased	54.12	11.30	47	220285	45513	63223177
Hospice care	53.98	11.30	98	220234	7834	63260856
Wrong technique in product usage process	53.89	11.30	386	219946	61954	63206736
Drug reaction with eosinophilia and systemic symptoms	53.77	11.30	25	220307	33811	63234879
Mouth swelling	53.74	11.30	74	220258	4666	63264024
Prescribed underdose	53.65	11.30	18	220314	29671	63239019
Oedema peripheral	53.60	11.30	411	219921	189100	63079590
Dental fistula	52.94	11.30	31	220301	609	63268081
Jaw fracture	52.85	11.30	55	220277	2579	63266111
Radius fracture	52.56	11.30	64	220268	3571	63265119
Musculoskeletal chest pain	52.56	11.30	177	220155	20906	63247784
Parathyroidectomy	52.13	11.30	23	220309	240	63268450
Parathyroid disorder	52.01	11.30	31	220301	630	63268060
Blood pressure increased	51.92	11.30	339	219993	161723	63106967
Neck pain	51.39	11.30	414	219918	68904	63199786
Obesity	51.00	11.30	20	220312	29932	63238758
Dysarthria	50.81	11.30	44	220288	42667	63226023
Injection site reaction	50.49	11.30	78	220254	58446	63210244
Polymyalgia rheumatica	50.41	11.30	64	220268	3727	63264963
Rhabdomyolysis	50.22	11.30	47	220285	43904	63224786
Depression	50.15	11.30	438	219894	196054	63072636
Drug ineffective for unapproved indication	49.90	11.30	28	220304	34035	63234655
Hand fracture	49.70	11.30	78	220254	5535	63263155
Dental discomfort	49.61	11.30	27	220305	458	63268232
Sleep disorder due to a general medical condition	49.55	11.30	122	220210	12066	63256624
Diarrhoea	49.52	11.30	2006	218326	713360	62555330
Aspartate aminotransferase increased	49.28	11.30	155	220177	90122	63178568
Septic shock	49.14	11.30	98	220234	66531	63202159
Dizziness	49.12	11.30	1127	219205	428798	62839892
Pancytopenia	49.08	11.30	172	220160	96761	63171929
Adverse reaction	48.98	11.30	109	220223	10094	63258596
Tremor	48.48	11.30	265	220067	131974	63136716
Orthostatic hypotension	48.43	11.30	33	220299	36127	63232563
Osteoporosis	48.39	11.30	353	219979	56985	63211705
Fluid retention	48.26	11.30	83	220249	59603	63209087
Scoliosis	48.12	11.30	93	220239	7795	63260895
Blood alkaline phosphatase decreased	47.85	11.30	37	220295	1168	63267522
Medication error	47.73	11.30	67	220265	52217	63216473
Rheumatoid nodule	47.58	11.30	3	220329	17152	63251538
Cognitive disorder	47.57	11.30	75	220257	55740	63212950
Hyperparathyroidism secondary	47.55	11.30	40	220292	1427	63267263
Haematochezia	47.51	11.30	70	220262	53474	63215216
Generalised tonic-clonic seizure	46.79	11.30	21	220311	28995	63239695
Dental prosthesis placement	46.27	11.30	15	220317	59	63268631
Sepsis	46.21	11.30	326	220006	152797	63115893
Vitamin D deficiency	46.19	11.30	129	220203	13763	63254927
Parathyroid tumour	45.84	11.30	18	220314	136	63268554
Product dose omission issue	45.70	11.30	1100	219232	233213	63035477
Periodontal disease	45.48	11.30	41	220291	1607	63267083
Fatigue	45.30	11.30	2572	217760	885456	62383234
Cardiac failure congestive	44.82	11.30	167	220165	92266	63176424
Hypophosphatasia	44.79	11.30	11	220321	9	63268681
Fibromyalgia	44.65	11.30	137	220195	80283	63188407
Device failure	44.43	11.30	77	220255	5934	63262756
Metastasis	44.34	11.30	71	220261	5126	63263564
Nasal congestion	43.92	11.30	102	220230	65558	63203132
Menopausal symptoms	43.41	11.30	48	220284	2413	63266277
Heart rate increased	43.30	11.30	174	220158	94064	63174626
Oral surgery	42.81	11.30	35	220297	1199	63267491
Abdominal pain upper	42.73	11.30	484	219848	205960	63062730
Drug-induced liver injury	42.54	11.30	46	220286	40176	63228514
Eosinophilia	42.53	11.30	13	220319	22743	63245947
Renal failure	42.45	11.30	237	220095	117415	63151275
Device dislocation	42.41	11.30	18	220314	25687	63243003
Noninfective gingivitis	42.05	11.30	37	220295	1404	63267286
Stevens-Johnson syndrome	41.92	11.30	17	220315	24933	63243757
Liver function test abnormal	41.77	11.30	64	220268	48117	63220573
Bone lesion	41.73	11.30	74	220258	5807	63262883
Gait disturbance	41.36	11.30	878	219454	182300	63086390
Hyperhidrosis	41.25	11.30	213	220119	107623	63161067
Oral infection	41.19	11.30	67	220265	4901	63263789
Pulmonary arterial hypertension	40.25	11.30	14	220318	22563	63246127
Right ventricular failure	39.88	11.30	6	220326	17182	63251508
Caesarean section	39.39	11.30	6	220326	17026	63251664
Drug dependence	39.04	11.30	18	220314	24465	63244225
Paraesthesia	38.94	11.30	763	219569	156203	63112487
Abdominal lymphadenopathy	38.93	11.30	27	220305	718	63267972
Status epilepticus	38.54	11.30	4	220328	15229	63253461
Parathyroid tumour malignant	38.38	11.30	11	220321	25	63268665
Bronchitis	38.17	11.30	265	220067	124670	63144020
Unevaluable event	38.13	11.30	307	220025	51079	63217611
Hypervolaemia	37.96	11.30	26	220306	28387	63240303
Product prescribing error	37.95	11.30	22	220310	26267	63242423
Oestrogen deficiency	37.95	11.30	16	220316	148	63268542
Ulna fracture	37.94	11.30	32	220300	1146	63267544
Bone resorption test abnormal	37.43	11.30	9	220323	6	63268684
Trismus	37.23	11.30	56	220276	3829	63264861
Injection site pruritus	37.16	11.30	62	220270	45054	63223636
Bone graft	36.79	11.30	29	220303	942	63267748
Staphylococcal infection	36.54	11.30	54	220278	41202	63227488
Aggression	36.36	11.30	18	220314	23480	63245210
Pulmonary fibrosis	36.35	11.30	51	220281	39758	63228932
Ventricular tachycardia	36.29	11.30	12	220320	19967	63248723
Pleural neoplasm	36.15	11.30	20	220312	351	63268339
Spinal operation	35.99	11.30	85	220247	8186	63260504
Contusion	35.86	11.30	340	219992	149704	63118986
Disease recurrence	35.68	11.30	27	220305	28003	63240687
Dyskinesia	35.66	11.30	35	220297	31967	63236723
Cytokine release syndrome	35.60	11.30	4	220328	14310	63254380
Injury associated with device	35.35	11.30	53	220279	3613	63265077
Metastases to pleura	35.27	11.30	35	220297	1550	63267140
Hypertension	35.07	11.30	721	219611	278582	62990108
Drug dose omission by device	34.83	11.30	61	220271	4740	63263950
Forearm fracture	34.74	11.30	22	220310	500	63268190
Immune system disorder	34.37	11.30	93	220239	9741	63258949
Tubulointerstitial nephritis	34.37	11.30	13	220319	19890	63248800
Amnesia	34.31	11.30	90	220242	55495	63213195
Cytomegalovirus infection	34.04	11.30	15	220317	20937	63247753
Product substitution issue	34.02	11.30	7	220325	15989	63252701
Blood glucose increased	34.00	11.30	162	220170	83594	63185096
Poisoning	33.65	11.30	4	220328	13696	63254994
Acute respiratory distress syndrome	33.54	11.30	20	220312	23514	63245176
Lichen planus	33.54	11.30	41	220291	2297	63266393
Haematemesis	33.04	11.30	34	220298	30378	63238312
Intentional product misuse	32.95	11.30	105	220227	60812	63207878
Cyanosis	32.89	11.30	9	220323	16926	63251764
White blood cell count increased	32.83	11.30	75	220257	48486	63220204
Neutropenia	32.72	11.30	817	219515	174188	63094502
Infusion site pain	32.70	11.30	9	220323	16860	63251830
Labelled drug-drug interaction medication error	32.69	11.30	4	220328	13395	63255295
Blood pressure fluctuation	32.57	11.30	70	220262	46247	63222443
Haematoma	32.40	11.30	44	220288	34776	63233914
Oral cavity fistula	32.04	11.30	23	220309	647	63268043
Obstructive airways disorder	31.81	11.30	16	220316	20683	63248007
Irritability	31.62	11.30	38	220294	31656	63237034
Hemiparesis	31.51	11.30	21	220311	23261	63245429
Withdrawal syndrome	31.43	11.30	15	220317	19982	63248708
Cholesteatoma	31.41	11.30	14	220318	150	63268540
Therapeutic product effect incomplete	31.34	11.30	280	220052	124776	63143914
Photophobia	31.33	11.30	11	220321	17624	63251066
Osteolysis	31.28	11.30	44	220288	2830	63265860
Feeling abnormal	31.17	11.30	704	219628	147688	63121002
COVID-19	31.16	11.30	247	220085	112856	63155834
Lymphoedema	30.78	11.30	100	220232	11592	63257098
Circulatory collapse	30.77	11.30	19	220313	21919	63246771
Metastases to peritoneum	30.71	11.30	48	220284	3394	63265296
Dementia	30.66	11.30	138	220194	18656	63250034
Mydriasis	30.62	11.30	3	220329	11953	63256737
Tachypnoea	30.38	11.30	11	220321	17291	63251399
Bronchospasm	30.32	11.30	11	220321	17269	63251421
Denture wearer	30.18	11.30	15	220317	209	63268481
Oral discomfort	30.16	11.30	85	220247	9116	63259574
Inflammation	30.07	11.30	165	220167	82108	63186582
Extrapyramidal disorder	30.00	11.30	5	220327	13279	63255411
Coagulopathy	29.93	11.30	17	220315	20527	63248163
Paranoia	29.72	11.30	3	220329	11676	63257014
Back disorder	29.71	11.30	95	220237	10922	63257768
Pulmonary hypertension	29.67	11.30	52	220280	37071	63231619
Respiratory distress	29.52	11.30	45	220287	33906	63234784
Patella fracture	29.49	11.30	37	220295	2129	63266561
Gastrointestinal disorder	29.43	11.30	302	220030	130937	63137753
Angioedema	29.35	11.30	78	220254	47887	63220803
Nightmare	29.26	11.30	15	220317	19179	63249511
Gingival operation	29.04	11.30	12	220320	105	63268585
Accidental overdose	28.97	11.30	23	220309	23286	63245404
Respiratory rate increased	28.97	11.30	6	220326	13642	63255048
Intercepted medication error	28.94	11.30	21	220311	601	63268089
Blood creatine phosphokinase increased	28.77	11.30	38	220294	30392	63238298
Facet joint syndrome	28.71	11.30	4	220328	12134	63256556
White blood cell count decreased	28.61	11.30	658	219674	138446	63130244
Hallucination, auditory	28.58	11.30	5	220327	12819	63255871
Palpitations	28.47	11.30	252	220080	112518	63156172
Therapy non-responder	28.42	11.30	151	220181	75750	63192940
Acute myeloid leukaemia	28.30	11.30	12	220320	17135	63251555
Onychoclasis	28.23	11.30	65	220267	6157	63262533
Chemotherapy	28.20	11.30	31	220301	1548	63267142
Bone giant cell tumour malignant	28.00	11.30	6	220326	0	63268690
Deep vein thrombosis	27.99	11.30	173	220159	83627	63185063
Pneumonia aspiration	27.95	11.30	48	220284	34492	63234198
Haemoglobin decreased	27.82	11.30	347	219985	145138	63123552
Kyphosis	27.82	11.30	39	220293	2501	63266189
Anuria	27.74	11.30	5	220327	12546	63256144
Gingival erythema	27.72	11.30	22	220310	722	63267968
Scab	27.72	11.30	74	220258	7689	63261001
Ill-defined disorder	27.72	11.30	168	220164	81587	63187103
Rash papular	27.67	11.30	118	220214	15584	63253106
Creatinine renal clearance decreased	27.58	11.30	11	220321	16297	63252393
Disorientation	27.43	11.30	60	220272	39392	63229298
Metastases to bladder	27.37	11.30	14	220318	208	63268482
Rash macular	27.18	11.30	156	220176	23208	63245482
Body temperature increased	27.17	11.30	55	220277	37137	63231553
Carcinoembryonic antigen increased	27.03	11.30	32	220300	1733	63266957
Pancreatitis	26.92	11.30	84	220248	48971	63219719
Transplant rejection	26.84	11.30	3	220329	10777	63257913
Ankle fracture	26.84	11.30	128	220204	17727	63250963
Abnormal behaviour	26.81	11.30	21	220311	21405	63247285
Wrong product administered	26.60	11.30	63	220269	6078	63262612
Vitamin D increased	26.41	11.30	21	220311	691	63267999
Colitis ulcerative	26.33	11.30	31	220301	26060	63242630
Hypoaesthesia oral	26.19	11.30	102	220230	12931	63255759
Upper respiratory tract infection	26.07	11.30	172	220160	81875	63186815
Acute respiratory failure	26.05	11.30	50	220282	34435	63234255
Sinus bradycardia	25.98	11.30	9	220323	14542	63254148
Ear pain	25.83	11.30	214	220118	35904	63232786
Hungry bone syndrome	25.79	11.30	11	220321	105	63268585
Renal tubular necrosis	25.68	11.30	5	220327	11873	63256817
Affect lability	25.62	11.30	4	220328	11147	63257543
Breast cancer stage III	25.59	11.30	3	220329	10383	63258307
Blood bilirubin increased	25.40	11.30	57	220275	37083	63231607
Oral disorder	25.39	11.30	78	220254	8776	63259914
Respiratory depression	25.33	11.30	8	220324	13707	63254983
General physical health deterioration	25.23	11.30	520	219812	200882	63067808
Inappropriate antidiuretic hormone secretion	25.23	11.30	11	220321	15451	63253239
Bone cancer	25.22	11.30	28	220304	1414	63267276
Abortion induced	25.13	11.30	3	220329	10239	63258451
Disturbance in attention	25.00	11.30	60	220272	38129	63230561
Sciatica	24.89	11.30	204	220128	34120	63234570
Calcinosis	24.76	11.30	34	220298	2138	63266552
Vision blurred	24.74	11.30	202	220130	91722	63176968
Metaphyseal corner fracture	24.57	11.30	8	220324	32	63268658
Diabetic ketoacidosis	24.54	11.30	21	220311	20484	63248206
Coronary artery disease	24.41	11.30	47	220285	32330	63236360
Posterior reversible encephalopathy syndrome	24.36	11.30	15	220317	17330	63251360
Cataract operation	24.30	11.30	57	220275	5465	63263225
Pallor	24.26	11.30	43	220289	30525	63238165
Schizophrenia	24.21	11.30	3	220329	9949	63258741
Rales	24.19	11.30	7	220325	12690	63256000
Nerve compression	24.18	11.30	78	220254	9009	63259681
Grip strength decreased	24.12	11.30	25	220307	22262	63246428
Shock haemorrhagic	24.03	11.30	3	220329	9892	63258798
Cellulitis	24.03	11.30	409	219923	81549	63187141
Gingival cyst	23.86	11.30	6	220326	6	63268684
Breast cancer recurrent	23.86	11.30	49	220283	4292	63264398
Vertebroplasty	23.76	11.30	15	220317	339	63268351
Blood creatinine abnormal	23.71	11.30	40	220292	3016	63265674
Pancreatitis acute	23.63	11.30	36	220296	27130	63241560
Pollakiuria	23.57	11.30	172	220160	27765	63240925
Pulmonary oedema	23.54	11.30	104	220228	54769	63213921
Dental prosthesis user	23.51	11.30	9	220323	63	63268627
Bone marrow failure	23.43	11.30	41	220291	29249	63239441
Drug resistance	23.41	11.30	27	220305	22906	63245784
Altered state of consciousness	23.36	11.30	32	220300	25198	63243492
Orthodontic procedure	23.34	11.30	5	220327	0	63268690
Parathyroid tumour benign	23.32	11.30	20	220312	733	63267957
Cardiogenic shock	23.18	11.30	17	220315	17915	63250775
Haemoptysis	23.17	11.30	40	220292	28686	63240004
Agranulocytosis	23.14	11.30	32	220300	25102	63243588
Hair disorder	23.05	11.30	24	220308	1126	63267564
Bacteraemia	23.01	11.30	16	220316	17332	63251358
Hot flush	22.89	11.30	275	220057	50884	63217806
Therapy interrupted	22.86	11.30	49	220283	32406	63236284
Malpositioned teeth	22.80	11.30	7	220325	22	63268668
Hepatitis	22.64	11.30	67	220265	39721	63228969
Frequent bowel movements	22.54	11.30	28	220304	22994	63245696
Hip surgery	22.47	11.30	41	220291	3290	63265400
Mastectomy	22.40	11.30	28	220304	1605	63267085
Cancer pain	22.32	11.30	40	220292	3165	63265525
Acetabulum fracture	22.31	11.30	14	220318	313	63268377
Rehabilitation therapy	22.17	11.30	28	220304	1622	63267068
Leukocytosis	21.95	11.30	35	220297	25900	63242790
Myoclonus	21.90	11.30	14	220318	15854	63252836
Palliative care	21.89	11.30	17	220315	540	63268150
Dysstasia	21.86	11.30	137	220195	21029	63247661
Haematocrit decreased	21.85	11.30	67	220265	39273	63229417
Amenorrhoea	21.80	11.30	4	220328	9910	63258780
Sputum discoloured	21.78	11.30	15	220317	16332	63252358
Acidosis	21.76	11.30	6	220326	11227	63257463
Hyperthermia	21.70	11.30	3	220329	9153	63259537
Akathisia	21.67	11.30	3	220329	9143	63259547
Hypothermia	21.63	11.30	10	220322	13571	63255119
Gingival ulceration	21.56	11.30	21	220311	909	63267781
Ataxia	21.53	11.30	13	220319	15182	63253508
Muscle tightness	21.41	11.30	90	220242	11810	63256880
Clavicle fracture	21.40	11.30	41	220291	3414	63265276
Bone sequestrum	21.39	11.30	26	220306	1448	63267242
Deformity	21.26	11.30	7	220325	11677	63257013
Hypokalaemia	21.21	11.30	244	220088	103560	63165130
Bone density increased	21.20	11.30	19	220313	739	63267951
Dental paraesthesia	21.00	11.30	5	220327	3	63268687
Blood 1,25-dihydroxycholecalciferol increased	21.00	11.30	5	220327	3	63268687
Serum procollagen type I N-terminal propeptide decreased	21.00	11.30	5	220327	3	63268687
Musculoskeletal disorder	20.93	11.30	133	220199	20511	63248179
Basal cell carcinoma	20.78	11.30	41	220291	27950	63240740
Paraesthesia oral	20.74	11.30	126	220206	19130	63249560
Adrenal insufficiency	20.65	11.30	19	220313	17896	63250794
Coordination abnormal	20.64	11.30	11	220321	13762	63254928
Pneumocystis jirovecii pneumonia	20.64	11.30	17	220315	16897	63251793
Macule	20.54	11.30	30	220302	1998	63266692
Delusion	20.50	11.30	8	220324	12009	63256681
Lupus-like syndrome	20.43	11.30	14	220318	15281	63253409
Panniculitis	20.40	11.30	7	220325	11378	63257312
Acute coronary syndrome	20.39	11.30	5	220327	10121	63258569
Restlessness	20.30	11.30	45	220287	29408	63239282
Cholelithiasis	20.23	11.30	81	220251	43844	63224846
Ventricular fibrillation	20.08	11.30	8	220324	11859	63256831
Triple negative breast cancer	20.08	11.30	10	220322	140	63268550
Myelosuppression	20.05	11.30	32	220300	23671	63245019
Alopecia	20.04	11.30	962	219370	336574	62932116
Walking aid user	20.03	11.30	82	220250	10635	63258055
Weight bearing difficulty	20.01	11.30	34	220298	2578	63266112
Diabetes mellitus inadequate control	19.99	11.30	14	220318	15112	63253578
Bone swelling	19.99	11.30	27	220305	1671	63267019
Blood glucose decreased	19.98	11.30	26	220306	20926	63247764
Haemorrhage	19.85	11.30	127	220205	60895	63207795
Illness	19.84	11.30	95	220237	48964	63219726
Atrial fibrillation	19.82	11.30	285	220047	116351	63152339
Oral mucosal erythema	19.76	11.30	26	220306	1569	63267121
Abscess oral	19.76	11.30	26	220306	1569	63267121
Limb discomfort	19.64	11.30	173	220159	29543	63239147
Chronic sinusitis	19.63	11.30	10	220322	12833	63255857
Ankylosing spondylitis	19.54	11.30	6	220326	10468	63258222
Injection site haemorrhage	19.48	11.30	34	220298	24280	63244410
Gestational diabetes	19.32	11.30	3	220329	8393	63260297
Injection site swelling	19.31	11.30	92	220240	47480	63221210
Breath sounds abnormal	19.23	11.30	7	220325	10966	63257724
Aphasia	19.19	11.30	55	220277	32945	63235745
Generalised oedema	19.17	11.30	16	220316	15802	63252888
Atelectasis	19.14	11.30	28	220304	21455	63247235
Peri-implantitis	19.07	11.30	8	220324	73	63268617
Bone erosion	19.03	11.30	20	220312	17697	63250993
Oral neoplasm benign	18.98	11.30	5	220327	7	63268683
Impaired healing	18.94	11.30	478	219854	102064	63166626
Injection site bruising	18.85	11.30	78	220254	41832	63226858
Decreased immune responsiveness	18.81	11.30	48	220284	4853	63263837
Metastases to meninges	18.80	11.30	33	220299	2569	63266121
Hepatocellular injury	18.74	11.30	42	220290	27339	63241351
VIth nerve paresis	18.70	11.30	8	220324	77	63268613
Thyroid calcification	18.67	11.30	4	220328	0	63268690
Shock	18.63	11.30	33	220299	23430	63245260
Vaccination site reaction	18.46	11.30	9	220323	120	63268570
CYP3A4 polymorphism	18.43	11.30	8	220324	80	63268610
Aspergillus infection	18.38	11.30	3	220329	8090	63260600
Renal injury	18.36	11.30	5	220327	9434	63259256
Skin necrosis	18.32	11.30	13	220319	13937	63254753
Eye irritation	18.27	11.30	30	220302	21941	63246749
Gingival injury	18.24	11.30	6	220326	25	63268665
Metastases to spinal cord	18.20	11.30	9	220323	124	63268566
Melaena	18.11	11.30	50	220282	30315	63238375
Sleep apnoea syndrome	18.11	11.30	47	220285	29086	63239604
Panic attack	18.10	11.30	31	220301	22300	63246390
Thrombotic microangiopathy	18.06	11.30	7	220325	10554	63258136
Gastroenteritis	18.02	11.30	41	220291	26549	63242141
Intermenstrual bleeding	17.86	11.30	3	220329	7923	63260767
Tumour marker abnormal	17.85	11.30	13	220319	374	63268316
Enthesopathy	17.85	11.30	4	220328	8610	63260080
Drug level decreased	17.84	11.30	3	220329	7916	63260774
Osteosarcoma	17.82	11.30	9	220323	130	63268560
Osteocalcin decreased	17.81	11.30	7	220325	53	63268637
Giant cell arteritis	17.79	11.30	30	220302	2261	63266429
Malocclusion	17.76	11.30	8	220324	88	63268602
Thyroid operation	17.75	11.30	10	220322	182	63268508
Bone deformity	17.58	11.30	15	220317	546	63268144
Vertebral wedging	17.56	11.30	5	220327	11	63268679
Diverticulitis	17.42	11.30	212	220120	39345	63229345
Allergy to plants	17.39	11.30	17	220315	739	63267951
Oliguria	17.37	11.30	5	220327	9096	63259594
Blood creatinine increased	17.36	11.30	208	220124	87636	63181054
Anaemia	17.27	11.30	837	219495	292593	62976097
Intervertebral disc protrusion	17.24	11.30	141	220191	23568	63245122
Metastases to adrenals	17.22	11.30	17	220315	748	63267942
Device malfunction	17.19	11.30	22	220310	17835	63250855
Root canal infection	17.18	11.30	13	220319	397	63268293
Progressive multifocal leukoencephalopathy	17.15	11.30	12	220320	12959	63255731
Mucosal pain	16.98	11.30	5	220327	13	63268677
Breast disorder	16.89	11.30	31	220301	2499	63266191
Ocular hyperaemia	16.86	11.30	39	220293	25105	63243585
Malabsorption	16.81	11.30	41	220291	4031	63264659
Mental disorder	16.74	11.30	41	220291	25878	63242812
Pre-existing condition improved	16.74	11.30	4	220328	8240	63260450
Pseudomonas infection	16.74	11.30	9	220323	11204	63257486
Subarachnoid haemorrhage	16.64	11.30	15	220317	14268	63254422
Lung neoplasm malignant	16.63	11.30	121	220211	19512	63249178
Stress	16.55	11.30	151	220181	67016	63201674
Bone marrow oedema	16.43	11.30	21	220311	1231	63267459
Metastatic neoplasm	16.42	11.30	42	220290	4253	63264437
Upper gastrointestinal haemorrhage	16.38	11.30	25	220307	18827	63249863
Colitis	16.30	11.30	100	220232	48428	63220262
Exostosis	16.25	11.30	112	220220	17750	63250940
Hepatic lesion	16.23	11.30	45	220287	4780	63263910
Angina pectoris	16.15	11.30	52	220280	30026	63238664
Cardiac murmur	16.11	11.30	16	220316	14536	63254154
Infusion site extravasation	16.11	11.30	8	220324	10418	63258272
Blood pressure abnormal	16.09	11.30	99	220233	15099	63253591
Productive cough	16.06	11.30	141	220191	63067	63205623
Dental cyst	16.05	11.30	6	220326	39	63268651
Lip dry	16.02	11.30	18	220314	15452	63253238
Bronchopulmonary aspergillosis	16.02	11.30	5	220327	8630	63260060
Lip exfoliation	15.97	11.30	15	220317	620	63268070
Parathyroid hormone-related protein increased	15.91	11.30	4	220328	4	63268686
Tartrate-resistant acid phosphatase increased	15.91	11.30	4	220328	4	63268686
Hypercalcaemic nephropathy	15.91	11.30	4	220328	4	63268686
Osteosclerosis	15.89	11.30	39	220293	3849	63264841
Metastases to bone marrow	15.81	11.30	13	220319	449	63268241
Gingival discolouration	15.81	11.30	11	220321	294	63268396
Pain of skin	15.77	11.30	81	220251	11553	63257137
Periprosthetic fracture	15.76	11.30	13	220319	451	63268239
Muscle atrophy	15.76	11.30	57	220275	6976	63261714
Osteomalacia	15.75	11.30	16	220316	729	63267961
Hypoaesthesia teeth	15.67	11.30	6	220326	42	63268648
Heart rate irregular	15.67	11.30	34	220298	22387	63246303
Myocardial infarction	15.63	11.30	248	220084	99645	63169045
Spinal disorder	15.62	11.30	72	220260	9830	63258860
Thrombocytopenia	15.62	11.30	402	219930	150755	63117935
Rotator cuff syndrome	15.61	11.30	90	220242	13412	63255278
Tooth discolouration	15.58	11.30	18	220314	950	63267740
Visual impairment	15.54	11.30	203	220129	84243	63184447
Sternal fracture	15.53	11.30	28	220304	2226	63266464
Adjustment disorder with depressed mood	15.51	11.30	8	220324	10196	63258494
Tenosynovitis	15.47	11.30	15	220317	13780	63254910
Mood altered	15.44	11.30	17	220315	14726	63253964
Medial tibial stress syndrome	15.40	11.30	8	220324	123	63268567
Adnexa uteri mass	15.31	11.30	14	220318	559	63268131
Hypovolaemia	15.31	11.30	9	220323	10664	63258026
Psychomotor hyperactivity	15.28	11.30	9	220323	10654	63258036
Acute hepatic failure	15.26	11.30	25	220307	18302	63250388
Infusion site erythema	15.19	11.30	11	220321	11668	63257022
Tricuspid valve incompetence	15.15	11.30	17	220315	14604	63254086
Epilepsy	15.09	11.30	46	220286	27019	63241671
Acute generalised exanthematous pustulosis	15.03	11.30	10	220322	11089	63257601
Encephalitis	15.00	11.30	6	220326	8874	63259816
Acute myocardial infarction	14.95	11.30	59	220273	32065	63236625
Osteochondrosis	14.87	11.30	21	220311	1356	63267334
Eastern Cooperative Oncology Group performance status worsened	14.86	11.30	20	220312	1234	63267456
Bone scan abnormal	14.83	11.30	12	220320	405	63268285
Vertigo	14.80	11.30	291	220041	59596	63209094
Oral pustule	14.77	11.30	6	220326	50	63268640
Carbohydrate antigen 15-3	14.72	11.30	7	220325	88	63268602
Bone infarction	14.71	11.30	11	220321	330	63268360
Activated partial thromboplastin time prolonged	14.69	11.30	3	220329	6890	63261800
Granuloma annulare	14.62	11.30	14	220318	593	63268097
Anger	14.61	11.30	13	220319	12443	63256247
Electrocardiogram QT prolonged	14.60	11.30	134	220198	59396	63209294
Rectal haemorrhage	14.48	11.30	105	220227	48925	63219765
Therapeutic response shortened	14.44	11.30	12	220320	11876	63256814
Cough	14.42	11.30	850	219482	291893	62976797
Tachyphylaxis	14.42	11.30	10	220322	266	63268424
Hepatic function abnormal	14.40	11.30	73	220259	37069	63231621
Brachiocephalic vein thrombosis	14.31	11.30	7	220325	94	63268596
Graft versus host disease	14.30	11.30	3	220329	6760	63261930
Pulmonary tumour thrombotic microangiopathy	14.28	11.30	6	220326	55	63268635
Rash erythematous	14.28	11.30	217	220115	42293	63226397
Hyperglycaemia	14.20	11.30	86	220246	41781	63226909
Inguinal hernia repair	14.18	11.30	6	220326	56	63268634
Diffuse large B-cell lymphoma	14.15	11.30	3	220329	6709	63261981
Urinary tract infection	14.14	11.30	1084	219248	263600	63005090
Ulcer	14.12	11.30	45	220287	26062	63242628
Cardiac failure	14.05	11.30	221	220111	88921	63179769
Febrile bone marrow aplasia	14.03	11.30	4	220328	7321	63261369
Masticatory pain	14.00	11.30	3	220329	0	63268690
C-telopeptide	14.00	11.30	3	220329	0	63268690
Sinus perforation	14.00	11.30	3	220329	0	63268690
Chronic leukaemia	13.98	11.30	4	220328	9	63268681
Vertebral lesion	13.96	11.30	14	220318	628	63268062
Hepatic steatosis	13.92	11.30	52	220280	28717	63239973
Blood urea increased	13.89	11.30	46	220286	26333	63242357
Onychalgia	13.88	11.30	17	220315	954	63267736
Pleural disorder	13.87	11.30	14	220318	633	63268057
Bone metabolism biochemical marker increased	13.85	11.30	5	220327	29	63268661
Myelodysplastic syndrome	13.82	11.30	23	220309	16731	63251959
Drug eruption	13.80	11.30	52	220280	28642	63240048
Device fastener issue	13.74	11.30	7	220325	103	63268587
Toxic encephalopathy	13.74	11.30	3	220329	6576	63262114
Oligodipsia	13.71	11.30	5	220327	30	63268660
Cervical vertebral fracture	13.62	11.30	29	220303	2605	63266085
Haemodialysis	13.62	11.30	7	220325	8940	63259750
Presyncope	13.59	11.30	50	220282	27735	63240955
Liver function test increased	13.58	11.30	63	220269	32748	63235942
Parathyroid gland operation	13.57	11.30	5	220327	31	63268659
Electrolyte imbalance	13.57	11.30	31	220301	20045	63248645
Neoplasm	13.57	11.30	56	220276	7289	63261401
Liver disorder	13.53	11.30	120	220212	53567	63215123
Pulmonary toxicity	13.52	11.30	8	220324	9447	63259243
Speech disorder	13.50	11.30	84	220248	40545	63228145
Hyperlipidaemia	13.49	11.30	115	220217	19456	63249234
Haemorrhage intracranial	13.48	11.30	16	220316	13403	63255287
Subdural haematoma	13.44	11.30	18	220314	14310	63254380
Skin sensitisation	13.42	11.30	16	220316	873	63267817
Carcinoid tumour pulmonary	13.40	11.30	12	220320	466	63268224
Proteinuria	13.40	11.30	29	220303	19116	63249574
Urine calcium increased	13.40	11.30	6	220326	65	63268625
Skin disorder	13.37	11.30	159	220173	29348	63239342
Enteritis	13.35	11.30	6	220326	8280	63260410
Bone fistula	13.32	11.30	6	220326	66	63268624
Eosinophil count increased	13.31	11.30	11	220321	10917	63257773
Dermatitis allergic	13.24	11.30	20	220312	15128	63253562
Apathy	13.21	11.30	7	220325	8787	63259903
Breast pain	13.17	11.30	63	220269	8735	63259955
Osteosarcoma recurrent	13.16	11.30	4	220328	12	63268678
Injected limb mobility decreased	13.16	11.30	4	220328	12	63268678
Hepatotoxicity	13.14	11.30	75	220257	36966	63231724
Urine abnormality	13.13	11.30	4	220328	7015	63261675
Dental plaque	13.12	11.30	7	220325	114	63268576
Platelet count increased	13.10	11.30	26	220306	17685	63251005
Tumour marker decreased	13.09	11.30	6	220326	69	63268621
Sinus congestion	13.07	11.30	27	220305	18096	63250594
Hypercalciuria	13.03	11.30	10	220322	312	63268378
Bradyphrenia	13.02	11.30	4	220328	6976	63261714
Hepatic encephalopathy	12.96	11.30	12	220320	11270	63257420
Female genital tract fistula	12.95	11.30	5	220327	7554	63261136
Fibula fracture	12.89	11.30	34	220298	3508	63265182
Respiratory disorder	12.88	11.30	81	220251	39001	63229689
Injection site urticaria	12.87	11.30	18	220314	14055	63254635
Demyelination	12.85	11.30	4	220328	6916	63261774
Metastases to neck	12.79	11.30	6	220326	73	63268617
Crying	12.79	11.30	40	220292	23303	63245387
Joint destruction	12.76	11.30	3	220329	6249	63262441
Breast cancer stage I	12.76	11.30	4	220328	6885	63261805
Hepatitis cholestatic	12.73	11.30	4	220328	6874	63261816
Blood 25-hydroxycholecalciferol decreased	12.72	11.30	6	220326	74	63268616
Skin exfoliation	12.59	11.30	215	220117	42887	63225803
Central nervous system lesion	12.59	11.30	11	220321	10624	63258066
Bronchiectasis	12.55	11.30	23	220309	16119	63252571
Respiratory tract congestion	12.49	11.30	27	220305	17805	63250885
Vaginal haemorrhage	12.46	11.30	51	220281	27436	63241254
Pulmonary embolism	12.41	11.30	309	220023	116375	63152315
Injection site warmth	12.40	11.30	21	220311	15174	63253516
Catheter site injury	12.39	11.30	9	220323	258	63268432
Nail avulsion	12.36	11.30	8	220324	189	63268501
Pneumonia viral	12.36	11.30	6	220326	7916	63260774
Rhinorrhoea	12.30	11.30	157	220175	65420	63203270
Jaw cyst	12.30	11.30	7	220325	130	63268560
Callus formation delayed	12.29	11.30	4	220328	16	63268674
Blood cholesterol abnormal	12.22	11.30	28	220304	2643	63266047
Clostridium difficile colitis	12.17	11.30	34	220298	20535	63248155
Nasal polyps	12.13	11.30	3	220329	6036	63262654
Metastases to vagina	12.09	11.30	4	220328	17	63268673
Nail growth abnormal	12.06	11.30	12	220320	533	63268157
Aspiration	11.94	11.30	12	220320	10839	63257851
Extradural neoplasm	11.93	11.30	3	220329	3	63268687
Vascular fragility	11.93	11.30	7	220325	138	63268552
Blood pressure systolic increased	11.92	11.30	106	220226	47291	63221399
Pulmonary haemorrhage	11.89	11.30	5	220327	7176	63261514
Polyglandular autoimmune syndrome type II	11.88	11.30	5	220327	46	63268644
Mitral valve incompetence	11.88	11.30	32	220300	19562	63249128
Fungal infection	11.86	11.30	77	220255	36797	63231893
Conjunctivitis	11.85	11.30	35	220297	20761	63247929
Oophorectomy	11.83	11.30	12	220320	546	63268144
Open fracture	11.77	11.30	11	220321	452	63268238
Invasive lobular breast carcinoma	11.73	11.30	15	220317	880	63267810
Mouth ulceration	11.71	11.30	170	220162	32814	63235876
Nail discolouration	11.68	11.30	28	220304	2722	63265968
Metastases to uterus	11.68	11.30	6	220326	90	63268600
Angina unstable	11.65	11.30	5	220327	7090	63261600
Rash maculo-papular	11.63	11.30	64	220268	31832	63236858
Injection site induration	11.60	11.30	9	220323	9217	63259473
Carcinoembryonic antigen	11.56	11.30	6	220326	92	63268598
Gastric disorder	11.53	11.30	79	220253	37290	63231400
Brain injury	11.51	11.30	5	220327	7038	63261652
Bone marrow infiltration	11.48	11.30	13	220319	671	63268019
Respiratory syncytial virus infection	11.44	11.30	5	220327	7013	63261677
Hypercalcaemia of malignancy	11.43	11.30	8	220324	216	63268474
Pharyngitis	11.40	11.30	34	220298	20109	63248581
Tumour flare	11.40	11.30	10	220322	378	63268312
Troponin increased	11.35	11.30	11	220321	10110	63258580
Pathogen resistance	11.35	11.30	4	220328	6394	63262296
Skin irritation	11.30	11.30	65	220267	9676	63259014

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Osteonecrosis of jaw	7799.88	14.01	2170	42211	15719	34896831
Off label use	3540.73	14.01	3405	40976	416119	34496431
Hypocalcaemia	1898.09	14.01	817	43564	23472	34889078
Death	1820.65	14.01	2359	42022	395690	34516860
Terminal state	569.40	14.01	207	44174	3727	34908823
Prostatic specific antigen increased	405.36	14.01	245	44136	14435	34898115
Metastases to bone	372.96	14.01	216	44165	11754	34900796
Tooth extraction	303.98	14.01	139	44242	4589	34907961
Tooth disorder	298.79	14.01	181	44200	10701	34901849
Malignant neoplasm progression	274.52	14.01	439	43942	87607	34824943
Bone pain	251.14	14.01	209	44172	20477	34892073
Investigation	245.93	14.01	77	44304	853	34911697
Pain in jaw	238.11	14.01	168	44213	12872	34899678
Atypical femur fracture	222.82	14.01	57	44324	277	34912273
Hospitalisation	207.14	14.01	305	44076	56597	34855953
Prostate cancer metastatic	205.76	14.01	114	44267	5689	34906861
Blood parathyroid hormone increased	205.46	14.01	76	44305	1438	34911112
Blood calcium decreased	188.94	14.01	132	44249	9952	34902598
Hypophosphataemia	173.87	14.01	130	44251	10896	34901654
Exposed bone in jaw	173.40	14.01	68	44313	1518	34911032
Toxicity to various agents	146.58	14.01	37	44344	200325	34712225
Jaw disorder	143.12	14.01	65	44316	2110	34910440
Hypercalcaemia	131.71	14.01	128	44253	15340	34897210
Drug ineffective	127.70	14.01	242	44139	456509	34456041
Osteomyelitis	121.68	14.01	125	44256	16011	34896539
Osteitis	118.55	14.01	52	44329	1552	34910998
Prostate cancer	108.96	14.01	187	44194	39462	34873088
Completed suicide	107.04	14.01	4	44377	98164	34814386
Toothache	106.73	14.01	78	44303	6310	34906240
Occupational exposure to product	103.14	14.01	32	44349	343	34912207
Drug interaction	97.72	14.01	86	44295	225860	34686690
Bone density abnormal	91.32	14.01	22	44359	79	34912471
Dental care	84.80	14.01	26	44355	267	34912283
Pathological fracture	83.45	14.01	58	44323	4333	34908217
Condition aggravated	83.25	14.01	73	44308	192123	34720427
Tooth fracture	82.79	14.01	54	44327	3631	34908919
Spinal fracture	79.22	14.01	70	44311	7428	34905122
Hormone-refractory prostate cancer	78.34	14.01	31	44350	709	34911841
Hot flush	77.74	14.01	105	44276	17961	34894589
Metastases to lung	75.38	14.01	75	44306	9245	34903305
Hypotension	75.24	14.01	103	44278	221546	34691004
Back pain	75.15	14.01	330	44051	121459	34791091
Abscess jaw	70.66	14.01	29	44352	731	34911819
Osteonecrosis	66.30	14.01	88	44293	14802	34897748
Acute kidney injury	65.29	14.01	186	44195	304802	34607748
Cardiac arrest	62.50	14.01	22	44359	96137	34816413
Dental implantation	60.60	14.01	15	44366	62	34912488
Femur fracture	59.55	14.01	62	44319	8062	34904488
Accidental exposure to product	57.52	14.01	76	44305	12726	34899824
Incorrect route of product administration	56.00	14.01	81	44300	14764	34897786
Delusion of grandeur	55.94	14.01	28	44353	1132	34911418
Metastases to lymph nodes	55.75	14.01	47	44334	4681	34907869
Cancer pain	54.81	14.01	37	44344	2635	34909915
Jaw operation	54.23	14.01	17	44364	189	34912361
Blood calcium abnormal	53.92	14.01	22	44359	546	34912004
Metastasis	52.61	14.01	43	44338	4101	34908449
Decreased appetite	52.34	14.01	376	44005	166016	34746534
Dental caries	51.22	14.01	44	44337	4495	34908055
Tooth loss	51.03	14.01	41	44340	3817	34908733
Fracture	49.72	14.01	52	44329	6797	34905753
Tetany	49.08	14.01	23	44358	803	34911747
Impaired healing	48.38	14.01	77	44304	15257	34897293
Thoracic vertebral fracture	48.04	14.01	29	44352	1701	34910849
Fatigue	47.96	14.01	697	43684	369956	34542594
Exostosis of jaw	47.43	14.01	13	44368	86	34912464
Bone fissure	45.42	14.01	10	44371	21	34912529
Endodontic procedure	45.15	14.01	18	44363	420	34912130
Bone density decreased	45.13	14.01	29	44352	1900	34910650
Agitation	43.06	14.01	10	44371	57389	34855161
Bradycardia	42.95	14.01	21	44360	75397	34837153
Blood phosphorus decreased	42.49	14.01	34	44347	3147	34909403
Metastases to liver	42.27	14.01	68	44313	13595	34898955
Tooth abscess	41.70	14.01	44	44337	5809	34906741
Rhinalgia	40.96	14.01	22	44359	1031	34911519
Drug hypersensitivity	40.71	14.01	26	44355	80503	34832047
Jaw fistula	40.66	14.01	10	44371	40	34912510
Hip fracture	40.57	14.01	62	44319	11863	34900687
Gastrointestinal haemorrhage	40.22	14.01	32	44349	88445	34824105
Peri-implantitis	38.90	14.01	12	44369	126	34912424
Metastases to central nervous system	38.86	14.01	50	44331	8155	34904395
Blood calcium increased	38.86	14.01	34	44347	3560	34908990
Loose tooth	36.10	14.01	21	44360	1150	34911400
Artificial crown procedure	35.96	14.01	8	44373	18	34912532
Cardio-respiratory arrest	35.29	14.01	13	44368	55260	34857290
Tachycardia	34.51	14.01	34	44347	84738	34827812
Coma	34.17	14.01	8	44373	45670	34866880
Bone loss	34.10	14.01	16	44365	560	34911990
Bone giant cell tumour malignant	34.02	14.01	6	44375	0	34912550
Neoplasm progression	33.28	14.01	84	44297	23216	34889334
Metastases to spine	33.20	14.01	27	44354	2557	34909993
Gingivitis	33.11	14.01	31	44350	3544	34909006
Chest pain	32.75	14.01	70	44311	126692	34785858
Suicidal ideation	32.43	14.01	6	44375	40382	34872168
Overdose	32.17	14.01	41	44340	91018	34821532
Stress fracture	31.99	14.01	18	44363	925	34911625
Gingival disorder	31.48	14.01	21	44360	1466	34911084
Atypical fracture	31.28	14.01	10	44371	119	34912431
Hungry bone syndrome	30.92	14.01	9	44372	76	34912474
Prostate cancer recurrent	30.79	14.01	18	44363	995	34911555
Periodontitis	30.73	14.01	23	44358	1929	34910621
Lymphocyte count abnormal	30.50	14.01	19	44362	1179	34911371
International normalised ratio increased	30.44	14.01	11	44370	47316	34865234
Disease progression	30.40	14.01	238	44143	107839	34804711
Hyperparathyroidism	30.13	14.01	19	44362	1205	34911345
Failure to anastomose	29.93	14.01	11	44370	204	34912346
Multiple organ dysfunction syndrome	29.70	14.01	32	44349	76534	34836016
Spinal pain	29.66	14.01	37	44344	5852	34906698
Lumbar vertebral fracture	29.22	14.01	24	44357	2305	34910245
Sequestrectomy	28.98	14.01	11	44370	224	34912326
Dental fistula	28.71	14.01	9	44372	100	34912450
Bone disorder	28.08	14.01	37	44344	6178	34906372
Alopecia	27.95	14.01	81	44300	24274	34888276
Abdominal pain	27.90	14.01	110	44271	163508	34749042
Septic shock	27.89	14.01	30	44351	71804	34840746
Hospice care	27.84	14.01	39	44342	6901	34905649
Carbohydrate antigen 15-3 increased	27.23	14.01	8	44373	70	34912480
Respiratory failure	27.18	14.01	61	44320	108511	34804039
Aggression	26.91	14.01	8	44373	38956	34873594
Mastication disorder	26.25	14.01	18	44363	1315	34911235
Bone lesion	26.12	14.01	25	44356	2938	34909612
Bone formation increased	26.01	14.01	5	44376	3	34912547
Palliative care	25.12	14.01	14	44367	706	34911844
Polyneuropathy in malignant disease	25.02	14.01	10	44371	235	34912315
Psoriasis	24.99	14.01	9	44372	38803	34873747
Pleurocutaneous fistula	24.84	14.01	7	44374	52	34912498
Febrile neutropenia	24.62	14.01	90	44291	136759	34775791
Affective disorder	24.57	14.01	29	44352	4331	34908219
Product storage error	24.55	14.01	40	44341	8082	34904468
Weight increased	24.33	14.01	51	44330	92982	34819568
Spinal compression fracture	24.21	14.01	37	44344	7079	34905471
Gingival abscess	24.05	14.01	9	44372	176	34912374
Confusional state	23.89	14.01	98	44283	144062	34768488
Nephrocalcinosis	23.71	14.01	13	44368	635	34911915
Product use in unapproved indication	23.36	14.01	74	44307	117425	34795125
Drug effective for unapproved indication	23.02	14.01	22	44359	2580	34909970
Wheezing	22.86	14.01	12	44369	41390	34871160
Pseudarthrosis	22.65	14.01	7	44374	74	34912476
Asthma	22.63	14.01	13	44368	42643	34869907
Gingival swelling	22.45	14.01	16	44365	1244	34911306
Metastases to soft tissue	22.44	14.01	11	44370	425	34912125
Cough	21.91	14.01	107	44274	150033	34762517
Respiratory distress	21.75	14.01	9	44372	35656	34876894
Parathyroid tumour malignant	21.44	14.01	5	44376	15	34912535
Tooth infection	21.35	14.01	34	44347	6737	34905813
Blood bilirubin increased	21.29	14.01	11	44370	38285	34874265
Treatment failure	21.07	14.01	17	44364	46680	34865870
Hypoglycaemia	21.00	14.01	23	44358	54617	34857933
Macroenzyme creatine kinase	20.97	14.01	5	44376	17	34912533
Suture rupture	20.90	14.01	10	44371	366	34912184
Myocardial infarction	20.89	14.01	81	44300	121004	34791546
Depression	20.85	14.01	59	44322	97039	34815511
Eosinophilia	20.83	14.01	4	44377	26218	34886332
Arthralgia	20.78	14.01	317	44064	169724	34742826
Pyrexia	20.73	14.01	298	44083	332715	34579835
Pericoronitis	20.45	14.01	4	44377	3	34912547
Anxiety	20.20	14.01	62	44319	99366	34813184
Jaw fracture	20.16	14.01	14	44367	1044	34911506
Coronary artery disease	20.08	14.01	19	44362	48286	34864264
Prostatic specific antigen abnormal	19.84	14.01	12	44369	706	34911844
Dental restoration failure	19.77	14.01	5	44376	23	34912527
Metabolic acidosis	19.59	14.01	16	44365	43664	34868886
Abnormal behaviour	19.43	14.01	4	44377	24965	34887585
Limbic encephalitis	19.34	14.01	10	44371	433	34912117
Bone fistula	19.26	14.01	5	44376	26	34912524
Angioedema	18.97	14.01	12	44369	37362	34875188
Alanine aminotransferase increased	18.94	14.01	47	44334	80768	34831782
Respiratory arrest	18.93	14.01	6	44375	28037	34884513
Chest discomfort	18.79	14.01	25	44356	54505	34858045
Haematemesis	18.58	14.01	6	44375	27705	34884845
Hyperaesthesia	18.54	14.01	26	44355	4604	34907946
Hallucination	18.37	14.01	23	44358	51475	34861075
Oxygen saturation decreased	18.21	14.01	25	44356	53793	34858757
Blood urea increased	17.98	14.01	8	44373	30356	34882194
Prostatic specific antigen decreased	17.94	14.01	7	44374	154	34912396
Abscess oral	17.89	14.01	9	44372	368	34912182
Tremor	17.86	14.01	50	44331	82537	34830013
Sepsis	17.81	14.01	131	44250	166430	34746120
Intercepted product administration error	17.69	14.01	8	44373	257	34912293
Ulna fracture	17.32	14.01	9	44372	394	34912156
Injury associated with device	17.16	14.01	13	44368	1110	34911440
Sedation	17.12	14.01	3	44378	21003	34891547
Abdominal distension	17.09	14.01	30	44351	58462	34854088
Dental operation	17.07	14.01	9	44372	406	34912144
Calcium ionised abnormal	17.01	14.01	3	44378	0	34912550
Vipoma	16.91	14.01	4	44377	13	34912537
Somnolence	16.90	14.01	78	44303	111038	34801512
Soft tissue disorder	16.87	14.01	11	44370	739	34911811
Inappropriate schedule of product administration	16.85	14.01	136	44245	62160	34850390
Acute respiratory distress syndrome	16.76	14.01	6	44375	25963	34886587
Shock	16.63	14.01	5	44376	24174	34888376
Lactic acidosis	16.53	14.01	12	44369	34760	34877790
Headache	16.47	14.01	169	44212	200466	34712084
Extraskeletal ossification	16.43	14.01	5	44376	50	34912500
Postrenal failure	16.29	14.01	9	44372	446	34912104
Blood glucose increased	16.27	14.01	38	44343	66680	34845870
Agranulocytosis	16.25	14.01	5	44376	23816	34888734
Acute myocardial infarction	16.20	14.01	27	44354	53692	34858858
Blood parathyroid hormone decreased	16.00	14.01	14	44367	1466	34911084
Toxic epidermal necrolysis	15.78	14.01	4	44377	21642	34890908
Poor peripheral circulation	15.78	14.01	14	44367	1493	34911057
Dysgeusia	15.69	14.01	71	44310	26426	34886124
Blood 1,25-dihydroxycholecalciferol increased	15.54	14.01	4	44377	20	34912530
Neoplasm malignant	15.47	14.01	58	44323	19847	34892703
Intentional product use issue	15.46	14.01	33	44348	59783	34852767
Carcinoid tumour of the small bowel	15.42	14.01	7	44374	227	34912323
Osteosclerosis	15.28	14.01	13	44368	1311	34911239
Asthenia	15.15	14.01	413	43968	244838	34667712
Cellulitis	15.09	14.01	117	44264	52834	34859716
Orthostatic hypotension	15.08	14.01	7	44374	25912	34886638
Noninfective gingivitis	15.07	14.01	8	44373	366	34912184
SARS-CoV-2 test positive	15.01	14.01	27	44354	5906	34906644
Nasal discomfort	14.85	14.01	14	44367	1614	34910936
Bedridden	14.81	14.01	21	44360	3757	34908793
Dyspnoea	14.79	14.01	365	44016	376417	34536133
Vitamin D increased	14.71	14.01	5	44376	73	34912477
Hypersensitivity	14.69	14.01	35	44346	61000	34851550
Paraesthesia	14.68	14.01	135	44246	64037	34848513
Product use issue	14.63	14.01	37	44344	63179	34849371
Oral cavity fistula	14.52	14.01	6	44375	154	34912396
Ascites	14.43	14.01	23	44358	46548	34866002
Bone giant cell tumour	14.40	14.01	4	44377	28	34912522
Lung cyst	14.40	14.01	4	44377	28	34912522
Cardiogenic shock	14.28	14.01	8	44373	26610	34885940
Anaphylactic reaction	14.27	14.01	12	44369	32289	34880261
Rebound effect	14.03	14.01	19	44362	3255	34909295

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	25747.47	11.32	20240	194722	886975	78642451
Osteonecrosis of jaw	14195.32	11.32	5060	209902	38166	79491260
Death	6161.63	11.32	7570	207392	558944	78970482
Hypocalcaemia	2498.10	11.32	1599	213363	48325	79481101
Bone pain	1813.92	11.32	1371	213591	54371	79475055
Tooth disorder	1697.99	11.32	991	213971	25242	79504184
Spinal fracture	1571.48	11.32	829	214133	17225	79512201
Atypical femur fracture	1407.36	11.32	529	214433	4660	79524766
Pain in jaw	1371.94	11.32	1076	213886	45075	79484351
Tooth extraction	1329.22	11.32	631	214331	10364	79519062
Back pain	1253.48	11.32	2622	212340	301558	79227868
Pain in extremity	1058.59	11.32	2739	212223	361799	79167627
Drug ineffective	893.52	11.32	963	213999	1079950	78449476
Bone density abnormal	884.82	11.32	327	214635	2733	79526693
Metastases to bone	790.06	11.32	599	214363	23828	79505598
Arthralgia	783.98	11.32	3330	211632	568473	78960953
Thoracic vertebral fracture	771.04	11.32	345	214617	4908	79524518
Toxicity to various agents	769.59	11.32	111	214851	421429	79107997
Tooth fracture	723.27	11.32	427	214535	11103	79518323
Myalgia	716.75	11.32	1560	213402	184081	79345345
Lumbar vertebral fracture	669.86	11.32	343	214619	6679	79522747
Toothache	666.44	11.32	499	214463	19471	79509955
Terminal state	638.44	11.32	296	214666	4593	79524833
Exposed bone in jaw	629.31	11.32	270	214692	3450	79525976
Completed suicide	615.81	11.32	9	214953	245758	79283668
Rebound effect	595.37	11.32	320	214642	6906	79522520
Bone density decreased	587.68	11.32	395	214567	12952	79516474
Femur fracture	549.93	11.32	597	214365	38055	79491371
Jaw disorder	516.91	11.32	258	214704	4748	79524678
Blood parathyroid hormone increased	504.78	11.32	226	214736	3219	79526207
Drug interaction	488.76	11.32	255	214707	414928	79114498
Spinal compression fracture	483.50	11.32	386	214576	16572	79512854
Pathological fracture	469.09	11.32	314	214648	10223	79519203
Hospitalisation	438.77	11.32	856	214106	93380	79436046
Investigation	432.12	11.32	181	214781	2170	79527256
Acute kidney injury	431.29	11.32	459	214503	518945	79010481
Tooth loss	428.03	11.32	256	214706	6819	79522607
Drug abuse	421.04	11.32	3	214959	162688	79366738
Groin pain	412.44	11.32	316	214646	12764	79516662
Dental implantation	404.11	11.32	120	214842	452	79528974
Condition aggravated	396.08	11.32	461	214501	500663	79028763
Osteomyelitis	391.57	11.32	463	214499	32402	79497024
Loose tooth	386.21	11.32	182	214780	2935	79526491
Hip fracture	384.23	11.32	444	214518	30317	79499109
Breast cancer metastatic	351.21	11.32	243	214719	8359	79521067
Bone loss	349.50	11.32	160	214802	2407	79527019
Hypotension	339.34	11.32	413	214549	439904	79089522
Neoplasm progression	329.94	11.32	539	214423	51143	79478283
Fracture	321.06	11.32	343	214619	21458	79507968
Infusion related reaction	319.19	11.32	111	214851	230126	79299300
Dental care	313.69	11.32	111	214851	807	79528619
Dental caries	311.51	11.32	257	214705	11563	79517863
Musculoskeletal pain	307.09	11.32	780	214182	101574	79427852
Blood calcium decreased	303.45	11.32	401	214561	31418	79498008
Accidental exposure to product	302.21	11.32	397	214565	30925	79498501
Drug intolerance	289.27	11.32	177	214785	263942	79265484
Synovitis	288.30	11.32	34	214928	150700	79378726
Maternal exposure during pregnancy	284.36	11.32	22	214940	136516	79392910
Metastases to liver	284.28	11.32	366	214596	27948	79501478
Treatment failure	277.78	11.32	60	214902	170426	79359000
Bone disorder	269.68	11.32	294	214668	18819	79510607
Intentional overdose	269.15	11.32	3	214959	105957	79423469
Product use in unapproved indication	266.97	11.32	173	214789	250186	79279240
Overdose	260.16	11.32	86	214876	184120	79345306
Contraindicated product administered	255.53	11.32	56	214906	157482	79371944
Exostosis of jaw	252.33	11.32	103	214859	1151	79528275
Exposure during pregnancy	247.79	11.32	5	214957	101127	79428299
Foot fracture	244.36	11.32	299	214663	21682	79507744
Blood calcium increased	243.00	11.32	211	214751	10189	79519237
Jaw operation	241.18	11.32	89	214873	740	79528686
Product storage error	240.18	11.32	256	214706	15970	79513456
Malignant neoplasm progression	238.78	11.32	858	214104	135132	79394294
Drug hypersensitivity	236.87	11.32	274	214688	298642	79230784
Pemphigus	236.07	11.32	7	214955	99575	79429851
Endodontic procedure	235.88	11.32	125	214837	2618	79526808
Prostatic specific antigen increased	231.21	11.32	205	214757	10181	79519245
Product use issue	227.77	11.32	142	214820	209680	79319746
Cardiac arrest	221.77	11.32	93	214869	172003	79357423
Confusional state	219.62	11.32	323	214639	317674	79211752
Therapeutic product effect decreased	218.59	11.32	84	214878	163779	79365647
Osteitis	213.72	11.32	133	214829	3810	79525616
Muscle spasms	197.29	11.32	963	213999	173767	79355659
Tooth abscess	192.45	11.32	228	214734	15982	79513444
Incorrect route of product administration	192.14	11.32	341	214621	34588	79494838
Bradycardia	191.88	11.32	63	214899	135494	79393932
Osteonecrosis	185.97	11.32	315	214647	30780	79498646
Compression fracture	184.03	11.32	147	214815	6313	79523113
Systemic lupus erythematosus	182.92	11.32	50	214912	121099	79408327
Gingival disorder	182.51	11.32	117	214845	3534	79525892
Suicide attempt	179.53	11.32	11	214951	82921	79446505
Hepatic enzyme increased	179.04	11.32	138	214824	182472	79346954
Stress fracture	177.27	11.32	144	214818	6336	79523090
Spinal pain	176.99	11.32	213	214749	15179	79514247
Mobility decreased	173.64	11.32	721	214241	121454	79407972
Gingivitis	171.48	11.32	163	214799	8858	79520568
Abscess jaw	171.45	11.32	87	214875	1660	79527766
Somnolence	168.61	11.32	239	214723	238742	79290684
Tachycardia	168.44	11.32	139	214823	177629	79351797
Wrist fracture	167.53	11.32	183	214779	11738	79517688
Hypercalcaemia	166.62	11.32	339	214623	38091	79491335
Pericarditis	165.10	11.32	39	214923	104197	79425229
Joint swelling	162.08	11.32	334	214628	288312	79241114
Temporomandibular joint syndrome	161.03	11.32	111	214851	3794	79525632
Tetany	160.59	11.32	97	214865	2631	79526795
Gingival pain	160.51	11.32	157	214805	8841	79520585
Cardio-respiratory arrest	159.71	11.32	47	214915	108463	79420963
Metastases to lung	159.60	11.32	220	214742	17943	79511483
Cystitis	159.26	11.32	403	214559	52329	79477097
Coma	158.74	11.32	38	214924	100611	79428815
Febrile neutropenia	158.07	11.32	236	214726	230763	79298663
Hypophosphataemia	156.96	11.32	229	214733	19684	79509742
Blood calcium abnormal	156.56	11.32	76	214886	1313	79528113
Intentional product use issue	155.51	11.32	110	214852	152002	79377424
Breast cancer	153.64	11.32	304	214658	33477	79495949
Lactic acidosis	153.31	11.32	9	214953	70350	79459076
Atypical fracture	152.42	11.32	61	214901	645	79528781
Helicobacter infection	151.62	11.32	9	214953	69695	79459731
Pelvic fracture	150.44	11.32	175	214787	12029	79517397
Periodontitis	149.19	11.32	112	214850	4384	79525042
Dyspnoea	147.87	11.32	1538	213424	855487	78673939
Sequestrectomy	147.23	11.32	63	214899	799	79528627
Duodenal ulcer perforation	145.71	11.32	8	214954	66203	79463223
Pyrexia	145.28	11.32	1153	213809	677556	78851870
Multiple organ dysfunction syndrome	142.46	11.32	73	214889	120173	79409253
Hand deformity	142.38	11.32	51	214911	103868	79425558
Gastrointestinal haemorrhage	140.55	11.32	115	214847	147604	79381822
Tooth infection	140.43	11.32	211	214751	18621	79510805
Vomiting	139.79	11.32	1137	213825	664691	78864735
Multiple fractures	139.37	11.32	138	214824	7888	79521538
Gingival swelling	137.99	11.32	108	214854	4501	79524925
Artificial crown procedure	136.74	11.32	44	214918	229	79529197
Agitation	136.50	11.32	49	214913	99666	79429760
Hyperaesthesia teeth	136.17	11.32	76	214886	1770	79527656
Osteonecrosis of external auditory canal	136.10	11.32	40	214922	144	79529282
Gingival recession	135.84	11.32	67	214895	1200	79528226
Fall	135.68	11.32	1953	213009	485676	79043750
Occupational exposure to product	132.37	11.32	55	214907	645	79528781
Carbohydrate antigen 15-3 increased	131.35	11.32	64	214898	1115	79528311
Depressed level of consciousness	129.77	11.32	49	214913	96603	79432823
International normalised ratio increased	129.71	11.32	34	214928	84687	79444739
Metastases to lymph nodes	128.01	11.32	149	214813	10248	79519178
Eczema	126.45	11.32	315	214647	40503	79488923
Hypoglycaemia	124.40	11.32	59	214903	101535	79427891
Suicidal ideation	122.01	11.32	28	214934	76312	79453114
Psoriatic arthropathy	121.92	11.32	30	214932	77969	79451457
Dental restoration failure	120.51	11.32	57	214905	927	79528499
Seizure	119.63	11.32	203	214759	188631	79340795
Abdominal pain	119.31	11.32	592	214370	388977	79140449
Wound	118.76	11.32	84	214878	116095	79413331
Folliculitis	117.92	11.32	8	214954	55372	79474054
Metabolic acidosis	117.39	11.32	38	214924	82491	79446935
Respiratory failure	116.90	11.32	192	214770	180719	79348707
Glossodynia	116.19	11.32	67	214895	103270	79426156
Musculoskeletal discomfort	116.05	11.32	199	214763	19636	79509790
Rib fracture	115.81	11.32	242	214720	27705	79501721
Tumour marker increased	110.71	11.32	92	214870	4180	79525246
Wheezing	109.52	11.32	92	214870	116572	79412854
Mastication disorder	109.24	11.32	76	214886	2637	79526789
Unresponsive to stimuli	108.09	11.32	12	214950	55776	79473650
Metastases to central nervous system	107.48	11.32	173	214789	16202	79513224
Pneumonia	107.17	11.32	1201	213761	659045	78870381
Weight increased	106.81	11.32	386	214576	277000	79252426
Serotonin syndrome	103.76	11.32	4	214958	45023	79484403
Metastases to spine	103.59	11.32	89	214873	4235	79525191
Oxygen saturation decreased	103.50	11.32	117	214845	128930	79400496
Hyponatraemia	103.01	11.32	202	214760	177646	79351780
Respiratory arrest	102.83	11.32	16	214946	57534	79471892
Vitamin D decreased	101.21	11.32	128	214834	9597	79519829
Muscle injury	100.58	11.32	8	214954	48553	79480873
Upper limb fracture	99.57	11.32	176	214786	17791	79511635
Prostate cancer metastatic	99.11	11.32	84	214878	3923	79525503
Bedridden	98.25	11.32	141	214821	11938	79517488
Hypoxia	96.19	11.32	82	214880	103161	79426265
Lower limb fracture	95	11.32	200	214762	23015	79506411
Encephalopathy	92.44	11.32	33	214929	67364	79462062
Femoral neck fracture	92.37	11.32	124	214838	9860	79519566
C-reactive protein abnormal	92.22	11.32	11	214951	48356	79481070
Rash pruritic	91.18	11.32	409	214553	71220	79458206
Alanine aminotransferase increased	90.43	11.32	189	214773	162381	79367045
Liver injury	90	11.32	21	214941	56593	79472833
Dental operation	88.89	11.32	49	214913	1113	79528313
Rhabdomyolysis	88.86	11.32	88	214874	103043	79426383
Septic shock	88.35	11.32	121	214841	122680	79406746
Anaphylactic reaction	86.30	11.32	60	214902	83683	79445743
Fractured sacrum	85.48	11.32	54	214908	1589	79527837
Hyperkalaemia	84.05	11.32	111	214851	114287	79415139
Hot flush	83.59	11.32	331	214631	54546	79474880
Hyperparathyroidism	82.66	11.32	69	214893	3155	79526271
Pain	81.80	11.32	2478	212484	701324	78828102
Drug level increased	80.83	11.32	7	214955	39644	79489782
Multiple sclerosis relapse	80.77	11.32	14	214948	46519	79482907
Neoplasm malignant	80.76	11.32	228	214734	31582	79497844
Toxic epidermal necrolysis	80.55	11.32	12	214950	44569	79484857
Jaw fistula	80.29	11.32	24	214938	93	79529333
Oral pain	79.84	11.32	227	214735	31571	79497855
Sepsis	79.81	11.32	414	214548	269014	79260412
Drug reaction with eosinophilia and systemic symptoms	79.12	11.32	37	214925	64207	79465219
Hospice care	78.87	11.32	117	214845	10207	79519219
Aggression	78.86	11.32	20	214942	50938	79478488
Influenza like illness	78.55	11.32	392	214570	71315	79458111
Body height decreased	78.52	11.32	106	214856	8474	79520952
Renal failure	78.43	11.32	278	214684	200690	79328736
Dental fistula	78.26	11.32	35	214927	497	79528929
Hypersensitivity	78.21	11.32	402	214560	261837	79267589
Paraesthesia	77.47	11.32	771	214191	175552	79353874
Abdominal discomfort	77.26	11.32	380	214582	250347	79279079
Inappropriate schedule of product administration	77.05	11.32	620	214342	133008	79396418
Gingival abscess	76.60	11.32	40	214922	812	79528614
Hallucination	76.39	11.32	71	214891	85674	79443752
Gait disturbance	76.09	11.32	875	214087	206631	79322795
Intercepted product administration error	74.91	11.32	32	214930	404	79529022
Eosinophilia	73.73	11.32	16	214946	45329	79484097
Tooth erosion	73.61	11.32	31	214931	377	79529049
Dermatitis	72.95	11.32	171	214791	21150	79508276
Product dose omission issue	72.90	11.32	1002	213960	246535	79282891
Syncope	72.88	11.32	244	214718	179205	79350221
Rheumatoid arthritis	72.57	11.32	302	214660	208168	79321258
Blood pressure decreased	72.57	11.32	97	214865	99369	79430057
Lower respiratory tract infection	72.05	11.32	150	214812	129070	79400356
Bone lesion	71.49	11.32	84	214878	5835	79523591
Intentional self-injury	71.07	11.32	4	214958	32415	79497011
Impaired healing	69.95	11.32	440	214522	87215	79442211
Oedema	69.93	11.32	135	214827	119445	79409981
Tibia fracture	69.66	11.32	79	214883	5282	79524144
Pancytopenia	68.94	11.32	223	214739	165522	79363904
Joint noise	68.39	11.32	68	214894	3906	79525520
Metastasis	67.58	11.32	88	214874	6792	79522634
Type 2 diabetes mellitus	67.16	11.32	35	214927	57087	79472339
Ventricular fibrillation	66.85	11.32	5	214957	31921	79497505
Neck pain	66.80	11.32	389	214573	75028	79454398
Orthostatic hypotension	66.65	11.32	34	214928	56130	79473296
Humerus fracture	66.12	11.32	102	214860	9211	79520215
Aspartate aminotransferase increased	66.04	11.32	175	214787	138466	79390960
Chest discomfort	65.94	11.32	174	214788	137870	79391556
Dry skin	65.03	11.32	358	214604	67637	79461789
Tooth resorption	64.92	11.32	16	214946	22	79529404
Chest pain	64.70	11.32	470	214492	281834	79247592
Blood creatine phosphokinase increased	64.66	11.32	50	214912	66040	79463386
Dental cleaning	64.46	11.32	15	214947	13	79529413
Loss of consciousness	64.40	11.32	234	214728	167709	79361717
Delirium	64.35	11.32	80	214882	84547	79444879
Abortion spontaneous	63.59	11.32	4	214958	29503	79499923
Haematochezia	63.40	11.32	86	214876	87559	79441867
Musculoskeletal chest pain	63.36	11.32	178	214784	24586	79504840
C-telopeptide increased	63.21	11.32	14	214948	7	79529419
Dental necrosis	63.13	11.32	22	214940	152	79529274
Pulpitis dental	62.98	11.32	41	214921	1272	79528154
Mental status changes	62.59	11.32	53	214909	66906	79462520
Injury	62.41	11.32	70	214892	77426	79452000
Prescribed overdose	62.34	11.32	13	214949	37870	79491556
Cytokine release syndrome	62.11	11.32	11	214951	35987	79493439
Intentional product misuse	61.44	11.32	101	214861	95064	79434362
Drug withdrawal syndrome	61.24	11.32	10	214952	34708	79494718
Blood phosphorus decreased	60.44	11.32	82	214880	6586	79522840
Dysarthria	60.23	11.32	56	214906	67566	79461860
Coronary artery disease	59.77	11.32	53	214909	65421	79464005
Swelling	59.75	11.32	341	214621	216370	79313056
Generalised tonic-clonic seizure	59.37	11.32	22	214940	43888	79485538
Sedation	59.25	11.32	33	214929	51862	79477564
Bone giant cell tumour malignant	59.03	11.32	12	214950	0	79529426
Labelled drug-drug interaction medication error	58.85	11.32	4	214958	27646	79501780
Mouth swelling	58.82	11.32	77	214885	5974	79523452
Cytomegalovirus infection	58.27	11.32	21	214941	42623	79486803
Acute respiratory distress syndrome	58.05	11.32	23	214939	44044	79485382
Product prescribing error	58.04	11.32	24	214938	44789	79484637
Parathyroid disorder	58.03	11.32	28	214934	477	79528949
Asthma	57.41	11.32	180	214782	134915	79394511
Device expulsion	57.29	11.32	3	214959	25858	79503568
Sleep disorder due to a general medical condition	57.26	11.32	122	214840	14155	79515271
Anxiety	56.81	11.32	414	214548	248098	79281328
Scoliosis	56.17	11.32	84	214878	7380	79522046
Heart rate decreased	56.10	11.32	64	214898	70252	79459174
Respiratory distress	55.98	11.32	45	214917	58294	79471132
Haematemesis	55.79	11.32	36	214926	52228	79477198
Angioedema	55.61	11.32	74	214888	75961	79453465
Ventricular tachycardia	55.05	11.32	22	214940	41913	79487513
Cancer pain	54.52	11.32	69	214893	5176	79524250
Myocardial infarction	54.46	11.32	283	214679	183846	79345580
Radius fracture	54.10	11.32	57	214905	3507	79525919
Cardiogenic shock	53.39	11.32	23	214939	41891	79487535
Drug-induced liver injury	52.94	11.32	60	214902	66057	79463369
Poisoning	52.79	11.32	4	214958	25268	79504158
Jaw fracture	52.62	11.32	52	214910	2965	79526461
Osteoporosis	52.48	11.32	286	214676	53826	79475600
Periodontal disease	52.09	11.32	42	214920	1828	79527598
Living in residential institution	51.74	11.32	29	214933	681	79528745
C-reactive protein increased	51.31	11.32	177	214785	128850	79400576
Drug ineffective for unapproved indication	51.10	11.32	38	214924	51200	79478226
Infection	50.86	11.32	412	214550	241300	79288126
Sinus tachycardia	50.73	11.32	18	214944	36890	79492536
Ulna fracture	50.67	11.32	34	214928	1111	79528315
Hyperparathyroidism secondary	50.43	11.32	48	214914	2612	79526814
Denture wearer	50.41	11.32	16	214946	79	79529347
Headache	50.26	11.32	1360	213602	652412	78877014
Hand fracture	49.65	11.32	72	214890	6153	79523273
Renal tubular necrosis	49.49	11.32	5	214957	25034	79504392
Parathyroid tumour malignant	49.32	11.32	14	214948	43	79529383
Osteoporotic fracture	49.27	11.32	59	214903	4181	79525245
Emotional distress	49.24	11.32	23	214939	39946	79489480
Sinusitis	48.97	11.32	317	214645	195184	79334242
Hungry bone syndrome	48.86	11.32	19	214943	185	79529241
Respiratory depression	48.64	11.32	8	214954	27622	79501804
Hormone-refractory prostate cancer	48.35	11.32	24	214938	436	79528990
Irritable bowel syndrome	48.20	11.32	58	214904	62183	79467243
Blood bilirubin increased	47.89	11.32	65	214897	66167	79463259
Acute myocardial infarction	47.67	11.32	84	214878	76952	79452474
Stevens-Johnson syndrome	47.54	11.32	23	214939	39143	79490283
Ear pain	47.45	11.32	195	214767	32674	79496752
Tachypnoea	46.96	11.32	14	214948	32049	79497377
Oral cavity fistula	46.48	11.32	27	214935	680	79528746
No adverse event	46.44	11.32	21	214941	37171	79492255
Lymphoedema	46.28	11.32	103	214859	12310	79517116
Disease recurrence	46.25	11.32	31	214931	44078	79485348
Tremor	46.13	11.32	269	214693	169814	79359612
Vitamin D deficiency	46.13	11.32	112	214850	14167	79515259
Polymyalgia rheumatica	46.08	11.32	59	214903	4478	79524948
Medication error	46.06	11.32	71	214891	68571	79460855
Vitamin D abnormal	46.00	11.32	17	214945	142	79529284
Circulatory collapse	45.91	11.32	22	214940	37646	79491780
Dental discomfort	45.89	11.32	23	214939	427	79528999
Oral infection	45.51	11.32	66	214896	5641	79523785
Accidental overdose	45.43	11.32	25	214937	39556	79489870
Abnormal behaviour	44.80	11.32	21	214941	36400	79493026
Red blood cell sedimentation rate abnormal	44.71	11.32	3	214959	20960	79508466
Status epilepticus	44.65	11.32	7	214955	25034	79504392
Cardiac failure congestive	44.31	11.32	215	214747	142187	79387239
Peri-implantitis	44.26	11.32	18	214944	199	79529227
Tubulointerstitial nephritis	44.11	11.32	24	214938	38211	79491215
Parathyroidectomy	44.03	11.32	18	214944	202	79529224
Noninfective gingivitis	44.00	11.32	36	214926	1600	79527826
Coagulopathy	43.93	11.32	21	214941	35985	79493441
Liver function test abnormal	43.92	11.32	66	214896	64409	79465017
Blood parathyroid hormone abnormal	43.72	11.32	21	214941	354	79529072
Obesity	43.60	11.32	20	214942	35105	79494321
Hyperhidrosis	43.58	11.32	235	214727	151257	79378169
Psoriasis	43.48	11.32	112	214850	89475	79439951
Spinal operation	43.15	11.32	77	214885	7840	79521586
Atrial fibrillation	43.15	11.32	334	214628	197552	79331874
Spinal deformity	42.86	11.32	29	214933	961	79528465
Dehydration	42.69	11.32	445	214517	247742	79281684
Pulmonary oedema	42.32	11.32	111	214851	88143	79441283
Drug dependence	42.28	11.32	29	214933	40740	79488686
Therapeutic response decreased	42.18	11.32	72	214890	66781	79462645
Blood creatinine increased	41.64	11.32	246	214716	154811	79374615
Shock	41.28	11.32	34	214928	43514	79485912
Dyskinesia	41.16	11.32	36	214926	44737	79484689
Product quality issue	41.09	11.32	20	214942	33920	79495506
Red blood cell sedimentation rate increased	40.97	11.32	38	214924	45904	79483522
Urinary tract infection	40.67	11.32	998	213964	273514	79255912
Torsade de pointes	40.50	11.32	3	214959	19309	79510117
Agranulocytosis	40.44	11.32	37	214925	44993	79484433
Pulmonary arterial hypertension	40.44	11.32	13	214949	28353	79501073
Blister	40.37	11.32	175	214787	119301	79410125
Bronchopulmonary aspergillosis	40.28	11.32	6	214956	22288	79507138
Incorrect dose administered	40.18	11.32	92	214870	76538	79452888
Product substitution issue	40.15	11.32	4	214958	20252	79509174
Bone graft	40.14	11.32	25	214937	717	79528709
Aspergillus infection	40.12	11.32	3	214959	19158	79510268
Heart rate increased	40.08	11.32	178	214784	120546	79408880
White blood cell count increased	39.63	11.32	89	214873	74544	79454882
Thrombocytopenia	39.59	11.32	491	214471	264768	79264658
Pancreatitis	39.58	11.32	78	214884	68497	79460929
PIK3CA-activated mutation	39.57	11.32	23	214939	580	79528846
Acute myeloid leukaemia	39.26	11.32	17	214945	30868	79498558
Blood pressure increased	39.26	11.32	372	214590	210988	79318438
Haematoma	38.99	11.32	50	214912	52145	79477281
Fluid retention	38.93	11.32	81	214881	69728	79459698
Obstructive airways disorder	38.91	11.32	18	214944	31441	79497985
Sciatica	38.80	11.32	185	214777	33037	79496389
Right ventricular failure	38.79	11.32	8	214954	23489	79505937
Walking aid user	38.73	11.32	85	214877	10063	79519363
Premature delivery	38.72	11.32	8	214954	23459	79505967
Staphylococcal infection	38.44	11.32	61	214901	58234	79471192
Muscle spasticity	38.29	11.32	6	214956	21469	79507957
Device failure	38.19	11.32	64	214898	6197	79523229
Transplant rejection	38.11	11.32	4	214958	19433	79509993
Onychoclasis	38.07	11.32	60	214902	5518	79523908
Metastases to skin	38.06	11.32	34	214928	1705	79527721
Cholesteatoma	37.87	11.32	14	214948	117	79529309
Therapy non-responder	37.80	11.32	125	214837	92180	79437246
Hemiparesis	37.72	11.32	22	214940	33711	79495715
Oral surgery	37.36	11.32	28	214934	1093	79528333
Pallor	37.35	11.32	48	214914	50014	79479412
Hypervolaemia	37.26	11.32	36	214926	42654	79486772
Adverse reaction	36.67	11.32	79	214883	9235	79520191
Respiratory rate increased	36.40	11.32	7	214955	21593	79507833
Mydriasis	36.27	11.32	3	214959	17640	79511786
Palliative care	36.22	11.32	26	214936	949	79528477
Flushing	35.83	11.32	120	214842	88148	79441278
Diabetic ketoacidosis	35.75	11.32	24	214938	34098	79495328
Alopecia	35.74	11.32	846	214116	230509	79298917
Paranoia	35.64	11.32	5	214957	19427	79509999
Feeling abnormal	35.52	11.32	615	214347	158584	79370842
Dental prosthesis user	35.41	11.32	10	214952	30	79529396
Unevaluable event	35.40	11.32	264	214698	55321	79474105
Cyanosis	35.10	11.32	12	214950	25170	79504256
Parathyroid tumour	34.93	11.32	12	214950	79	79529347
Blood pressure fluctuation	34.90	11.32	81	214881	67064	79462362
Shock haemorrhagic	34.89	11.32	6	214956	20054	79509372
Psychotic disorder	34.89	11.32	36	214926	41366	79488060
Upper gastrointestinal haemorrhage	34.85	11.32	36	214926	41344	79488082
Ataxia	34.78	11.32	12	214950	25027	79504399
Blood alkaline phosphatase decreased	34.50	11.32	33	214929	1807	79527619
Blood glucose increased	34.38	11.32	176	214786	114799	79414627
Restlessness	34.25	11.32	45	214917	46447	79482979
Acute respiratory failure	34.12	11.32	68	214894	59473	79469953
Disorientation	34.03	11.32	74	214888	62702	79466724
Pneumocystis jirovecii pneumonia	33.87	11.32	23	214939	32485	79496941
Kyphosis	33.86	11.32	39	214923	2652	79526774
Dental prosthesis placement	33.79	11.32	9	214953	20	79529406
Withdrawal syndrome	33.79	11.32	15	214947	26839	79502587
Metastases to meninges	33.73	11.32	45	214917	3556	79525870
Nerve compression	33.70	11.32	76	214886	9163	79520263
Bone marrow failure	33.21	11.32	54	214908	51053	79478373
Hypothermia	33.19	11.32	10	214952	22736	79506690
Musculoskeletal disorder	33.16	11.32	130	214832	21318	79508108
Parathyroid tumour benign	33.11	11.32	23	214939	796	79528630
Oral discomfort	33.09	11.32	78	214884	9682	79519744
Haemodynamic instability	33.02	11.32	4	214958	17378	79512048
Gingival erythema	33.00	11.32	21	214941	626	79528800
Bone sequestrum	32.96	11.32	27	214935	1202	79528224
Injection site reaction	32.76	11.32	61	214901	54724	79474702
Intercepted medication error	32.75	11.32	24	214938	905	79528521
Cognitive disorder	32.73	11.32	89	214873	69837	79459589
Menopausal symptoms	32.70	11.32	33	214929	1930	79527496
Bone swelling	32.63	11.32	31	214931	1683	79527743
Gingival operation	32.47	11.32	11	214951	69	79529357
Intervertebral disc protrusion	32.43	11.32	138	214824	23483	79505943
Mastectomy	32.36	11.32	26	214936	1126	79528300
Pleural neoplasm	32.29	11.32	17	214945	351	79529075
Blood urea increased	32.22	11.32	51	214911	48739	79480687
Hypoaesthesia	32.17	11.32	670	214292	178682	79350744
Decreased immune responsiveness	32.12	11.32	55	214907	5420	79524006
Leukocytosis	32.07	11.32	42	214920	43413	79486013
Pulmonary hypertension	32.00	11.32	50	214912	48030	79481396
Nausea	31.82	11.32	2188	212774	955008	78574418
Delusion of grandeur	31.34	11.32	28	214934	1404	79528022
Injection site erythema	31.27	11.32	107	214855	78090	79451336
Muscle tightness	31.26	11.32	91	214871	12823	79516603
Melaena	31.21	11.32	74	214888	60816	79468610
Haemoptysis	31.20	11.32	65	214897	55934	79473492
Dizziness	31.19	11.32	1133	213829	525308	79004118
Bone fissure	31.17	11.32	13	214949	154	79529272
Irritability	31.16	11.32	39	214923	41105	79488321
Haematocrit decreased	31.04	11.32	75	214887	61237	79468189
Calcinosis	30.98	11.32	35	214927	2330	79527096
Wrong technique in product usage process	30.95	11.32	320	214642	73555	79455871
Angina unstable	30.91	11.32	4	214958	16523	79512903
Oedema peripheral	30.87	11.32	486	214476	251802	79277624
Pseudomonas infection	30.84	11.32	9	214953	20894	79508532
Ankle fracture	30.54	11.32	108	214854	16861	79512565
Cataract operation	30.30	11.32	52	214910	5133	79524293
Nightmare	30.17	11.32	16	214946	25845	79503581
Hypoaesthesia oral	29.95	11.32	95	214867	14029	79515397
Delusion	29.76	11.32	9	214953	20414	79509012
Angina pectoris	29.72	11.32	59	214903	51673	79477753
Hepatic encephalopathy	29.62	11.32	14	214948	24152	79505274
Renal injury	29.58	11.32	5	214957	16922	79512504
Breast disorder	29.33	11.32	32	214930	2049	79527377
Hepatitis	29.14	11.32	67	214895	55660	79473766
Breast cancer recurrent	29.12	11.32	38	214924	2939	79526487
Nasal congestion	29.10	11.32	107	214855	76445	79452981
Circumstance or information capable of leading to medication error	29.10	11.32	44	214918	3904	79525522
Arthritis	29.03	11.32	453	214509	114427	79414999
Drug resistance	28.96	11.32	43	214919	42170	79487256
White blood cell count decreased	28.91	11.32	688	214274	187600	79341826
Aphasia	28.87	11.32	51	214911	46681	79482745
Discomfort	28.81	11.32	209	214753	125408	79404018
Osteolysis	28.81	11.32	47	214915	4451	79524975
Deep vein thrombosis	28.80	11.32	199	214763	120720	79408706
Musculoskeletal stiffness	28.79	11.32	317	214645	174691	79354735
Nasopharyngitis	28.78	11.32	496	214466	253385	79276041
Subarachnoid haemorrhage	28.74	11.32	15	214947	24450	79504976
Pneumonia aspiration	28.60	11.32	89	214873	66878	79462548
Forearm fracture	28.42	11.32	18	214944	532	79528894
Colitis ulcerative	28.39	11.32	31	214931	34711	79494715
Photophobia	28.23	11.32	10	214952	20518	79508908
Epstein-Barr virus infection	28.18	11.32	3	214959	14413	79515013
Pancreatitis acute	28.13	11.32	57	214905	49547	79479879
Hyperthermia	28.06	11.32	7	214955	18030	79511396
Arthropathy	27.88	11.32	324	214638	176787	79352639
Myelosuppression	27.69	11.32	41	214921	40255	79489171
Adverse drug reaction	27.54	11.32	287	214675	66105	79463321
Anuria	27.51	11.32	11	214951	20952	79508474
Back disorder	27.47	11.32	81	214881	11497	79517929
Thrombotic microangiopathy	27.44	11.32	10	214952	20159	79509267
Depression	27.41	11.32	415	214547	216375	79313051
Metastases to bladder	27.31	11.32	14	214948	273	79529153
Dysstasia	27.13	11.32	147	214815	27599	79501827
Bone fistula	27.11	11.32	10	214952	83	79529343
Rales	27.07	11.32	10	214952	19991	79509435
Tumour marker abnormal	27.00	11.32	14	214948	280	79529146
Blood 1,25-dihydroxycholecalciferol increased	26.97	11.32	8	214954	30	79529396
Altered state of consciousness	26.91	11.32	48	214914	43774	79485652
Posterior reversible encephalopathy syndrome	26.85	11.32	19	214943	26262	79503164
Weight bearing difficulty	26.78	11.32	38	214924	3183	79526243
Haemorrhage intracranial	26.67	11.32	19	214943	26174	79503252
Abscess oral	26.62	11.32	26	214936	1461	79527965
Creatinine renal clearance decreased	26.58	11.32	9	214953	18993	79510433
Metaphyseal corner fracture	26.56	11.32	8	214954	32	79529394
Acidosis	26.55	11.32	10	214952	19752	79509674
Haemodialysis	26.48	11.32	8	214954	18160	79511266
Tartrate-resistant acid phosphatase increased	26.46	11.32	6	214956	4	79529422
Therapeutic product effect incomplete	26.42	11.32	249	214713	141396	79388030
Haemorrhage	26.39	11.32	141	214821	90977	79438449
Acute coronary syndrome	26.28	11.32	12	214950	21121	79508305
Limb discomfort	26.26	11.32	165	214797	32685	79496741
Sinus bradycardia	26.12	11.32	18	214944	25229	79504197
Disturbance in attention	25.82	11.32	62	214900	50739	79478687
Haemoglobin decreased	25.80	11.32	432	214530	221687	79307739
Jaundice	25.65	11.32	67	214895	53282	79476144
Pulmonary fibrosis	25.60	11.32	50	214912	44062	79485364
Pathogen resistance	25.59	11.32	4	214958	14338	79515088
Bone resorption test abnormal	25.37	11.32	6	214956	6	79529420
Bronchospasm	25.36	11.32	18	214944	24841	79504585
Activated partial thromboplastin time prolonged	25.31	11.32	4	214958	14224	79515202
Bone formation increased	25.25	11.32	9	214953	67	79529359
Abdominal lymphadenopathy	25.16	11.32	24	214938	1310	79528116
Osteoarthritis	25.08	11.32	352	214610	86957	79442469
Immune system disorder	25.07	11.32	76	214886	10953	79518473
Hepatocellular injury	25.06	11.32	57	214905	47536	79481890
Dementia	25.04	11.32	132	214830	24527	79504899
Atelectasis	25.04	11.32	30	214932	32227	79497199
Immobile	25.03	11.32	57	214905	6916	79522510
Migraine	25.00	11.32	136	214826	87357	79442069
COVID-19	24.99	11.32	288	214674	157386	79372040
Rehabilitation therapy	24.97	11.32	28	214934	1849	79527577
Device dislocation	24.96	11.32	20	214942	25950	79503476
Osteosclerosis	24.77	11.32	41	214921	3930	79525496
Paraesthesia oral	24.63	11.32	115	214847	20356	79509070
Bone deformity	24.63	11.32	14	214948	338	79529088
Trismus	24.61	11.32	49	214913	5418	79524008
Oral neoplasm benign	24.59	11.32	5	214957	0	79529426
Calcium ionised abnormal	24.59	11.32	5	214957	0	79529426
Cellulitis	24.57	11.32	422	214540	108638	79420788
Myoclonus	24.52	11.32	23	214939	27637	79501789
Hair disorder	24.51	11.32	22	214940	1110	79528316
Cardiac failure	24.47	11.32	283	214679	154559	79374867
Carcinoembryonic antigen increased	24.47	11.32	30	214932	2179	79527247
Rectal haemorrhage	24.42	11.32	114	214848	76186	79453240
Polyneuropathy in malignant disease	24.41	11.32	13	214949	275	79529151
Hepatitis cholestatic	24.41	11.32	4	214958	13848	79515578
Vertebroplasty	24.24	11.32	13	214949	279	79529147
Vitamin D increased	24.18	11.32	17	214945	600	79528826
Acetabulum fracture	24.01	11.32	17	214945	607	79528819
Gingival injury	23.86	11.32	7	214955	25	79529401
Hallucination, visual	23.78	11.32	32	214930	32697	79496729
Heart rate irregular	23.69	11.32	32	214930	32647	79496779
Progressive multifocal leukoencephalopathy	23.66	11.32	13	214949	20587	79508839
Hip surgery	23.60	11.32	36	214926	3219	79526207
Drug level decreased	23.58	11.32	5	214957	14397	79515029
Bone cancer	23.39	11.32	28	214934	1984	79527442
Peripheral swelling	23.29	11.32	551	214411	269066	79260360
Inappropriate antidiuretic hormone secretion	23.18	11.32	22	214940	26291	79503135
Adnexa uteri mass	23.17	11.32	14	214948	380	79529046
Rash macular	23.00	11.32	145	214817	28754	79500672
Akathisia	22.98	11.32	4	214958	13255	79516171
Hypophosphatasia	22.75	11.32	8	214954	57	79529369
Subdural haematoma	22.57	11.32	31	214931	31403	79498023
Hepatic cytolysis	22.44	11.32	24	214938	27127	79502299
Frequent bowel movements	22.37	11.32	28	214934	29511	79499915
Pulmonary haemorrhage	22.34	11.32	6	214956	14711	79514715
Acute hepatic failure	22.33	11.32	29	214933	30084	79499342
Sleep disorder due to general medical condition, insomnia type	22.27	11.32	53	214909	43503	79485923
Basal cell carcinoma	22.01	11.32	42	214920	37333	79492093
Bacteraemia	21.97	11.32	34	214928	32790	79496636
Lower gastrointestinal haemorrhage	21.93	11.32	8	214954	16117	79513309
Nephropathy toxic	21.88	11.32	14	214948	20405	79509021
Hepatic lesion	21.86	11.32	54	214908	6905	79522521
Enthesopathy	21.26	11.32	3	214959	11605	79517821
Gingival ulceration	21.18	11.32	19	214943	958	79528468
Patella fracture	21.13	11.32	26	214936	1895	79527531
Triple negative breast cancer	21.11	11.32	9	214953	113	79529313
Anger	20.95	11.32	10	214952	17152	79512274
Dysgeusia	20.88	11.32	241	214721	56936	79472490
Hyperglycaemia	20.83	11.32	108	214854	70227	79459199
Sudden death	20.81	11.32	18	214944	22493	79506933
Thyroid operation	20.64	11.32	10	214952	172	79529254
Vaccination site reaction	20.63	11.32	9	214953	120	79529306
Myocardial ischaemia	20.60	11.32	23	214939	25496	79503930
Oral disorder	20.58	11.32	67	214895	10028	79519398
Lichen planus	20.42	11.32	31	214931	2760	79526666
Traumatic fracture	20.41	11.32	19	214943	1005	79528421
Root canal infection	20.41	11.32	13	214949	388	79529038
Injection site pruritus	20.41	11.32	53	214909	42230	79487196
Erysipelas	20.34	11.32	70	214892	10780	79518646
Quality of life decreased	20.21	11.32	68	214894	10352	79519074
Drug dose omission by device	20.16	11.32	49	214913	6201	79523225
Brain oedema	20.14	11.32	23	214939	25240	79504186
Prostate cancer recurrent	19.93	11.32	17	214945	801	79528625
Coordination abnormal	19.77	11.32	11	214951	17301	79512125
Chemotherapy	19.69	11.32	24	214938	1733	79527693
Serum procollagen type I N-terminal propeptide decreased	19.68	11.32	4	214958	0	79529426
Haematuria	19.66	11.32	107	214855	68729	79460697
Acute generalised exanthematous pustulosis	19.65	11.32	11	214951	17243	79512183
Pleurocutaneous fistula	19.65	11.32	7	214955	52	79529374
Scab	19.64	11.32	68	214894	10504	79518922
Presyncope	19.40	11.32	52	214910	41002	79488424
Electrocardiogram QRS complex prolonged	19.38	11.32	3	214959	10830	79518596
Productive cough	19.28	11.32	149	214813	88182	79441244
Hepatic failure	19.27	11.32	92	214870	61120	79468306
Caesarean section	19.24	11.32	5	214957	12530	79516896
Oligodipsia	19.18	11.32	6	214956	28	79529398
Ascites	19.17	11.32	122	214840	75440	79453986
Hypovolaemia	19.13	11.32	12	214950	17679	79511747
Medial tibial stress syndrome	19.10	11.32	9	214953	145	79529281
Rotator cuff syndrome	19.08	11.32	82	214880	14013	79515413
Rash maculo-papular	19.02	11.32	82	214880	55996	79473430
Bone scan abnormal	18.93	11.32	10	214952	208	79529218
Metastases to neck	18.84	11.32	6	214956	30	79529396
Hepatomegaly	18.82	11.32	14	214948	18860	79510566
Rash papular	18.73	11.32	112	214850	21804	79507622
Bone marrow oedema	18.57	11.32	23	214939	1688	79527738
Breath sounds abnormal	18.48	11.32	10	214952	15974	79513452
Hypokalaemia	18.45	11.32	275	214687	143765	79385661
Prostate cancer	18.42	11.32	153	214809	33115	79496311
Haemophagocytic lymphohistiocytosis	18.38	11.32	19	214943	21818	79507608
Diffuse large B-cell lymphoma	18.35	11.32	5	214957	12144	79517282
Facet joint syndrome	18.35	11.32	4	214958	11298	79518128
Exostosis	18.34	11.32	92	214870	16766	79512660
Device fastener issue	18.25	11.32	8	214954	108	79529318
Clavicle fracture	18.22	11.32	38	214924	4343	79525083
Failure to anastomose	18.19	11.32	10	214952	226	79529200
Pneumonia fungal	18.13	11.32	4	214958	11206	79518220
Respiratory acidosis	18.11	11.32	4	214958	11196	79518230
Transaminases increased	17.96	11.32	75	214887	51668	79477758
Sarcoma	17.96	11.32	17	214945	919	79528507
Tricuspid valve incompetence	17.94	11.32	16	214946	19696	79509730
Metastases to bone marrow	17.85	11.32	16	214946	806	79528620
CYP3A4 polymorphism	17.84	11.32	7	214955	70	79529356
Pollakiuria	17.75	11.32	166	214796	37151	79492275
Prostatic specific antigen decreased	17.75	11.32	7	214955	71	79529355
Oliguria	17.73	11.32	11	214951	16298	79513128
Onychalgia	17.71	11.32	17	214945	935	79528491
Infusion site pain	17.71	11.32	8	214954	14168	79515258
Macroenzyme creatine kinase	17.70	11.32	5	214957	15	79529411
Lung neoplasm malignant	17.69	11.32	132	214830	27660	79501766
Lymphocyte count abnormal	17.61	11.32	21	214941	1482	79527944
Aspiration	17.59	11.32	17	214945	20141	79509285
Splenomegaly	17.54	11.32	18	214944	20736	79508690
Palpitations	17.53	11.32	238	214724	126372	79403054
Prescribed underdose	17.52	11.32	33	214929	29481	79499945
Degenerative bone disease	17.49	11.32	8	214954	120	79529306
Mucosal pain	17.46	11.32	5	214957	16	79529410
Dental paraesthesia	17.45	11.32	4	214958	3	79529423
Diverticulitis	17.39	11.32	195	214767	45741	79483685
COVID-19 pneumonia	17.36	11.32	32	214930	28817	79500609
Skin necrosis	17.29	11.32	14	214948	18073	79511353
Colitis	17.27	11.32	121	214841	73186	79456240
Vertebral wedging	17.23	11.32	5	214957	17	79529409
Dental cyst	17.23	11.32	5	214957	17	79529409
Erectile dysfunction	17.21	11.32	9	214953	14655	79514771
Disease progression	17.16	11.32	633	214329	183729	79345697
Cholecystitis chronic	17.15	11.32	3	214959	9903	79519523
Metastases to peritoneum	17.12	11.32	37	214925	4335	79525091
Electrolyte imbalance	17.07	11.32	36	214926	30845	79498581
Thyroid mass	17.05	11.32	35	214927	3955	79525471
Hypertension	17.03	11.32	724	214238	330268	79199158
Myelodysplastic syndrome	17.02	11.32	35	214927	30266	79499160
Nail avulsion	16.97	11.32	8	214954	129	79529297
Aplastic anaemia	16.94	11.32	14	214948	17891	79511535
Allergy to plants	16.93	11.32	15	214947	744	79528682
Hypercalciuria	16.92	11.32	13	214949	527	79528899
Brain injury	16.92	11.32	5	214957	11512	79517914
Hypercalcaemic nephropathy	16.91	11.32	4	214958	4	79529422
Atrial flutter	16.90	11.32	20	214942	21605	79507821
Cerebral haemorrhage	16.83	11.32	89	214873	57584	79471842
Blood pressure abnormal	16.81	11.32	91	214871	17078	79512348
Pulmonary alveolar haemorrhage	16.78	11.32	5	214957	11452	79517974
Burning sensation	16.68	11.32	236	214726	58396	79471030
Giant cell arteritis	16.62	11.32	28	214934	2723	79526703
VIth nerve paresis	16.54	11.32	8	214954	137	79529289
Spinal disorder	16.53	11.32	63	214899	10197	79519229
Duodenal ulcer	16.50	11.32	12	214950	16357	79513069
Macule	16.43	11.32	29	214933	2928	79526498
Parathyroid gland operation	16.41	11.32	5	214957	21	79529405
Neoplasm	16.39	11.32	58	214904	9058	79520368
Diabetes mellitus inadequate control	16.37	11.32	25	214937	24239	79505187
Osteocalcin decreased	16.35	11.32	6	214956	49	79529377
Pericoronitis	16.35	11.32	6	214956	49	79529377
Extraskeletal ossification	16.34	11.32	7	214955	89	79529337
Epilepsy	16.27	11.32	56	214906	40804	79488622
Abdominal pain upper	16.25	11.32	469	214493	223350	79306076
Oral mucosal erythema	16.21	11.32	23	214939	1927	79527499
Treatment noncompliance	16.20	11.32	79	214883	52189	79477237
Spondylolisthesis	16.19	11.32	30	214932	3145	79526281
Gamma-glutamyltransferase increased	16.17	11.32	84	214878	54596	79474830
Bronchiectasis	16.15	11.32	22	214940	22364	79507062
Myopathy	16.09	11.32	19	214943	20544	79508882
Thyroid calcification	16.03	11.32	4	214958	6	79529420
Carbohydrate antigen 15-3	16.00	11.32	7	214955	94	79529332
Blood uric acid increased	15.98	11.32	8	214954	13352	79516074
Hyperammonaemia	15.96	11.32	5	214957	11088	79518338
Wisdom teeth removal	15.91	11.32	12	214950	473	79528953
Vertigo	15.80	11.32	268	214694	68814	79460612
Blood creatinine abnormal	15.79	11.32	38	214924	4779	79524647
Fibromyalgia	15.75	11.32	105	214857	64235	79465191
Atrioventricular block complete	15.70	11.32	13	214949	16597	79512829
Hepatotoxicity	15.69	11.32	78	214884	51274	79478152
Drug eruption	15.67	11.32	63	214899	43872	79485554
Metastases to soft tissue	15.54	11.32	13	214949	596	79528830
Rhinalgia	15.52	11.32	25	214937	2342	79527084
Therapeutic response shortened	15.51	11.32	12	214950	15851	79513575
Neurotoxicity	15.51	11.32	41	214921	32477	79496949
Tuberculosis	15.51	11.32	11	214951	15187	79514239
Proteinuria	15.49	11.32	41	214921	32461	79496965
Fibula fracture	15.44	11.32	32	214930	3642	79525784
Eosinophil count increased	15.42	11.32	14	214948	17091	79512335
Panniculitis	15.42	11.32	7	214955	12364	79517062
Sense of oppression	15.33	11.32	20	214942	1546	79527880
Vertebral lesion	15.32	11.32	13	214949	608	79528818
Gingival discolouration	15.31	11.32	9	214953	232	79529194
Periprosthetic fracture	15.27	11.32	13	214949	611	79528815
Skin sensitisation	15.26	11.32	16	214946	979	79528447
Mitral valve incompetence	15.21	11.32	34	214928	28531	79500895
Sleep apnoea syndrome	15.21	11.32	49	214913	36429	79492997
Lung infiltration	15.08	11.32	24	214938	22888	79506538
Sputum discoloured	15.06	11.32	22	214940	21721	79507705
Upper respiratory tract infection	15.04	11.32	165	214797	91003	79438423
Toxic encephalopathy	15.02	11.32	6	214956	11434	79517992
Blood glucose decreased	15.00	11.32	30	214932	26204	79503222
Liver disorder	14.95	11.32	124	214838	72293	79457133
Bradyphrenia	14.95	11.32	5	214957	10635	79518791
Hyperbilirubinaemia	14.93	11.32	27	214935	24491	79504935
Tumour lysis syndrome	14.90	11.32	26	214936	23913	79505513
Hypercapnia	14.84	11.32	3	214959	8932	79520494
Diabetic endorgan damage	14.76	11.32	3	214959	0	79529426
Periodontal operation	14.76	11.32	3	214959	0	79529426
Sinus perforation	14.76	11.32	3	214959	0	79529426
Chronic leukaemia	14.69	11.32	4	214958	10	79529416
Metastases to chest wall	14.67	11.32	12	214950	533	79528893
Encephalitis	14.65	11.32	11	214951	14749	79514677
Osteomalacia	14.65	11.32	19	214943	1461	79527965
Ventricular arrhythmia	14.61	11.32	3	214959	8837	79520589
Cataract	14.58	11.32	242	214720	61878	79467548
Device malfunction	14.56	11.32	22	214940	21426	79508000
Catheter site injury	14.55	11.32	9	214953	255	79529171
Pelvic pain	14.54	11.32	73	214889	13308	79516118
Mental disorder	14.53	11.32	40	214922	31262	79498164
Lip exfoliation	14.50	11.32	13	214949	655	79528771
Clostridium difficile colitis	14.43	11.32	42	214920	32241	79497185
Diarrhoea	14.43	11.32	2118	212844	878371	78651055
Immune thrombocytopenia	14.42	11.32	16	214946	17789	79511637
Intramedullary rod insertion	14.42	11.32	8	214954	184	79529242
Fibroblast growth factor 23 increased	14.42	11.32	4	214958	11	79529415
Catatonia	14.42	11.32	3	214959	8753	79520673
Amnesia	14.41	11.32	105	214857	62952	79466474
Hypocalcaemic seizure	14.39	11.32	6	214956	71	79529355
Plantar fasciitis	14.38	11.32	30	214932	3430	79525996
Breast pain	14.36	11.32	52	214910	8213	79521213
Sternal fracture	14.30	11.32	25	214937	2505	79526921
Blood pressure systolic decreased	14.23	11.32	6	214956	11070	79518356
Inflammation	14.17	11.32	173	214789	93580	79435846
Carbohydrate antigen 19-9 increased	14.15	11.32	11	214951	454	79528972
Vision blurred	13.97	11.32	201	214761	105697	79423729
Vipoma	13.92	11.32	4	214958	13	79529413
Vascular fragility	13.92	11.32	7	214955	131	79529295
Febrile bone marrow aplasia	13.85	11.32	9	214953	13011	79516415
Therapy interrupted	13.85	11.32	41	214921	31300	79498126
Malpositioned teeth	13.83	11.32	5	214957	39	79529387
Troponin increased	13.81	11.32	19	214943	19236	79510190
Cholestasis	13.81	11.32	83	214879	52026	79477400
Invasive lobular breast carcinoma	13.80	11.32	13	214949	698	79528728
Malocclusion	13.77	11.32	7	214955	134	79529292
Atrophic vulvovaginitis	13.76	11.32	17	214945	1244	79528182
Speech disorder	13.76	11.32	88	214874	54357	79475069
Surgery	13.75	11.32	142	214820	32624	79496802
Hypovolaemic shock	13.73	11.32	8	214954	12268	79517158
Hypoaesthesia teeth	13.72	11.32	5	214957	40	79529386
Tenosynovitis	13.71	11.32	13	214949	15541	79513885
Blood culture positive	13.65	11.32	3	214959	8426	79521000
Fistula	13.64	11.32	70	214892	12870	79516556
Blood phosphorus abnormal	13.63	11.32	9	214953	286	79529140
Osteosarcoma	13.62	11.32	10	214952	378	79529048
Neuropathy peripheral	13.59	11.32	487	214475	140818	79388608
Ankylosing spondylitis	13.59	11.32	8	214954	12197	79517229
Fear	13.57	11.32	24	214938	21962	79507464
Electrocardiogram ST segment elevation	13.57	11.32	3	214959	8394	79521032
Hypotonia	13.55	11.32	9	214953	12861	79516565
Extradural neoplasm	13.48	11.32	4	214958	15	79529411
Exposure to toxic agent	13.41	11.32	4	214958	9154	79520272
Parkinsonism	13.33	11.32	15	214947	16569	79512857
Hepatic necrosis	13.28	11.32	4	214958	9096	79520330
Skin disorder	13.27	11.32	145	214817	33798	79495628
Atrioventricular block	13.26	11.32	11	214951	14030	79515396
Urine abnormality	13.16	11.32	3	214959	8216	79521210
Product administration error	13.12	11.32	43	214919	31803	79497623
Ocular hyperaemia	13.12	11.32	36	214926	28170	79501256
Bacterial sepsis	13.11	11.32	3	214959	8195	79521231
Metastases to vagina	13.09	11.32	4	214958	17	79529409
Osteoporosis postmenopausal	13.09	11.32	4	214958	17	79529409
Affect lability	13.08	11.32	7	214955	11252	79518174
High turnover osteopathy	13.01	11.32	5	214957	47	79529379
Carcinoembryonic antigen	13.00	11.32	6	214956	92	79529334
Vulvovaginal rash	13.00	11.32	6	214956	92	79529334
Product monitoring error	12.84	11.32	4	214958	8902	79520524
International normalised ratio decreased	12.81	11.32	3	214959	8067	79521359
Generalised oedema	12.81	11.32	28	214934	23681	79505745
Mouth ulceration	12.77	11.32	159	214803	38235	79491191
Pulmonary tumour thrombotic microangiopathy	12.77	11.32	6	214956	96	79529330
BRCA2 gene mutation	12.77	11.32	6	214956	96	79529330
Skin haemorrhage	12.76	11.32	65	214897	11916	79517510
Cardiomegaly	12.74	11.32	33	214929	26319	79503107
General physical health deterioration	12.73	11.32	609	214353	274629	79254797
Metastases to pituitary gland	12.73	11.32	4	214958	19	79529407
Demyelination	12.70	11.32	3	214959	8020	79521406
Tachyphylaxis	12.69	11.32	9	214953	322	79529104
Post procedural haemorrhage	12.69	11.32	11	214951	13733	79515693
Parathyroid hormone-related protein increased	12.69	11.32	3	214959	3	79529423
Injection site haemorrhage	12.65	11.32	36	214926	27834	79501592
Blood magnesium decreased	12.62	11.32	82	214880	16430	79512996
Anaphylactic shock	12.60	11.32	52	214910	35944	79493482
Conjunctivitis	12.59	11.32	32	214930	25683	79503743
Appendicitis	12.57	11.32	23	214939	20771	79508655
Chronic sinusitis	12.56	11.32	10	214952	13016	79516410
Rhinovirus infection	12.54	11.32	3	214959	7950	79521476
Cerebral haematoma	12.51	11.32	3	214959	7939	79521487
Leukoencephalopathy	12.48	11.32	3	214959	7926	79521500
Eastern Cooperative Oncology Group performance status worsened	12.45	11.32	21	214941	2044	79527382
Acute pulmonary oedema	12.42	11.32	12	214950	14218	79515208
Mood altered	12.42	11.32	18	214944	17829	79511597
Nail disorder	12.42	11.32	64	214898	11788	79517638
Bone cancer metastatic	12.41	11.32	8	214954	244	79529182
Deformity thorax	12.40	11.32	4	214958	21	79529405
Drug tolerance	12.32	11.32	4	214958	8671	79520755
Carbohydrate antigen 27.29 increased	12.32	11.32	5	214957	55	79529371
Staphylococcal bacteraemia	12.26	11.32	9	214953	12209	79517217
Respiratory syncytial virus infection	12.23	11.32	5	214957	9397	79520029
Gingival cyst	12.23	11.32	3	214959	4	79529422
Cementoplasty	12.23	11.32	3	214959	4	79529422
Dermatitis exfoliative	12.20	11.32	7	214955	10822	79518604
Cholecystitis	12.19	11.32	26	214936	22186	79507240
Urine calcium increased	12.19	11.32	6	214956	107	79529319
Body temperature increased	12.17	11.32	70	214892	44350	79485076
Bladder disorder	12.16	11.32	53	214909	9112	79520314
Medical device removal	12.16	11.32	12	214950	683	79528743
Catheter site bruise	12.15	11.32	10	214952	448	79528978
Sexual dysfunction	12.10	11.32	3	214959	7760	79521666
Prostatic specific antigen abnormal	12.10	11.32	10	214952	451	79528975
Cervical vertebral fracture	12.04	11.32	29	214933	3649	79525777
Skin plaque	12.03	11.32	7	214955	10738	79518688
Euphoric mood	12.01	11.32	3	214959	7723	79521703
Fatigue	12.01	11.32	2754	212208	926973	78602453
Muscle rigidity	12.01	11.32	22	214940	19860	79509566
Colonoscopy	12.01	11.32	20	214942	1927	79527499
Injected limb mobility decreased	11.96	11.32	4	214958	24	79529402
Chromaturia	11.87	11.32	33	214929	25713	79503713
Spinal cord compression	11.83	11.32	41	214921	6336	79523090
Intervertebral disc degeneration	11.82	11.32	78	214884	15707	79513719
Ileus	11.79	11.32	34	214928	26177	79503249
Jaundice cholestatic	11.73	11.32	8	214954	11276	79518150
Psychomotor hyperactivity	11.72	11.32	17	214945	16832	79512594
Laryngitis viral	11.71	11.32	5	214957	63	79529363
Pneumonia viral	11.70	11.32	5	214957	9153	79520273
Metastatic neoplasm	11.70	11.32	35	214927	5007	79524419
Enterococcal infection	11.70	11.32	15	214947	15645	79513781
Tooth discolouration	11.68	11.32	15	214947	1142	79528284
Bone operation	11.67	11.32	8	214954	271	79529155
Gastroenteritis radiation	11.66	11.32	12	214950	718	79528708
Lumbar spinal stenosis	11.63	11.32	36	214926	5246	79524180
Amylase increased	11.59	11.32	8	214954	11201	79518225
Ear disorder	11.52	11.32	30	214932	3963	79525463
Hydrocalyx	11.48	11.32	3	214959	6	79529420
Dental alveolar anomaly	11.43	11.32	4	214958	28	79529398
Lymphopenia	11.42	11.32	43	214919	30514	79498912
Naevus haemorrhage	11.35	11.32	6	214956	125	79529301
Visual acuity reduced	11.32	11.32	41	214921	29428	79499998
Major depression	11.32	11.32	5	214957	8975	79520451
Nail growth abnormal	11.32	11.32	10	214952	494	79528932

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M05BX04	MUSCULO-SKELETAL SYSTEM DRUGS FOR TREATMENT OF BONE DISEASES DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION Other drugs affecting bone structure and mineralization
MeSH PA	D050071	Bone Density Conservation Agents
FDA MoA	N0000187054	RANK Ligand Blocking Activity
FDA EPC	N0000187055	RANK Ligand Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Drug-induced osteoporosis	indication	14651005
Osteoporosis	indication	64859006	DOID:11476
Postmenopausal osteoporosis	indication	102447009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Tumor necrosis factor ligand superfamily member 11	Cytokine	O14788	TNF11_HUMAN	ANTIBODY BINDING				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D03684	KEGG_DRUG
4030131	VUID
N0000181718	NUI
4030131	VANDF
CHEMBL1237023	ChEMBL_ID
6886	IUPHAR_LIGAND_ID
DB06643	DRUGBANK_ID
993449	RXNORM
173191	MMSL
27218	MMSL
d07640	MMSL
013441	NDDF
446321003	SNOMEDCT_US
446457007	SNOMEDCT_US
C1690432	UMLSCUI
D000069448	MESH_DESCRIPTOR_UI
8653	INN_ID
4EQZ6YO2HI	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Prolia	HUMAN PRESCRIPTION DRUG LABEL	1	55513-710	INJECTION	60 mg	SUBCUTANEOUS	BLA	34 sections
Prolia	HUMAN PRESCRIPTION DRUG LABEL	1	55513-710	INJECTION	60 mg	SUBCUTANEOUS	BLA	34 sections
Prolia	HUMAN PRESCRIPTION DRUG LABEL	1	55513-710	INJECTION	60 mg	SUBCUTANEOUS	BLA	34 sections
XGEVA	HUMAN PRESCRIPTION DRUG LABEL	1	55513-730	INJECTION	120 mg	SUBCUTANEOUS	BLA	29 sections
XGEVA	HUMAN PRESCRIPTION DRUG LABEL	1	55513-730	INJECTION	120 mg	SUBCUTANEOUS	BLA	29 sections
XGEVA	HUMAN PRESCRIPTION DRUG LABEL	1	55513-730	INJECTION	120 mg	SUBCUTANEOUS	BLA	29 sections