Stem definition | Drug id | CAS RN |
---|---|---|
human origin | 4965 | 615258-40-7 |
Molecule | Description |
---|---|
Synonyms:
|
A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS.
|
Dose | Unit | Route |
---|---|---|
0.33 | mg | P |
None
Date | Agency | Company | Orphan |
---|---|---|---|
May 26, 2010 | EMA | Amgen Europe B.V. | |
June 1, 2010 | FDA | AMGEN |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Off label use | 48997.36 | 11.45 | 27249 | 174636 | 447177 | 49956062 |
Osteonecrosis of jaw | 9928.87 | 11.45 | 4014 | 197871 | 28512 | 50374727 |
Death | 5539.68 | 11.45 | 6623 | 195262 | 318756 | 50084483 |
Spinal fracture | 2247.79 | 11.45 | 1142 | 200743 | 14431 | 50388808 |
Bone pain | 1941.21 | 11.45 | 1565 | 200320 | 45664 | 50357575 |
Tooth disorder | 1774.93 | 11.45 | 1141 | 200744 | 23087 | 50380152 |
Hypocalcaemia | 1721.80 | 11.45 | 1163 | 200722 | 25653 | 50377586 |
Pain in jaw | 1386.16 | 11.45 | 1181 | 200704 | 37247 | 50365992 |
Drug ineffective | 1365.04 | 11.45 | 795 | 201090 | 818538 | 49584701 |
Atypical femur fracture | 1327.29 | 11.45 | 557 | 201328 | 4359 | 50398880 |
Tooth extraction | 1235.38 | 11.45 | 640 | 201245 | 8435 | 50394804 |
Back pain | 1151.40 | 11.45 | 2639 | 199246 | 217391 | 50185848 |
Pain in extremity | 1043.26 | 11.45 | 2905 | 198980 | 269960 | 50133279 |
Myalgia | 937.46 | 11.45 | 1735 | 200150 | 122584 | 50280655 |
Bone density abnormal | 772.04 | 11.45 | 330 | 201555 | 2715 | 50400524 |
Occupational exposure to product | 767.79 | 11.45 | 284 | 201601 | 1516 | 50401723 |
Tooth fracture | 717.50 | 11.45 | 459 | 201426 | 9192 | 50394047 |
Bone density decreased | 704.90 | 11.45 | 478 | 201407 | 10597 | 50392642 |
Accidental exposure to product | 688.41 | 11.45 | 637 | 201248 | 22420 | 50380819 |
Fracture | 682.78 | 11.45 | 554 | 201331 | 16279 | 50386960 |
Rebound effect | 654.74 | 11.45 | 298 | 201587 | 2891 | 50400348 |
Thoracic vertebral fracture | 650.17 | 11.45 | 320 | 201565 | 3753 | 50399486 |
Arthralgia | 642.62 | 11.45 | 3441 | 198444 | 435261 | 49967978 |
Toothache | 579.92 | 11.45 | 505 | 201380 | 16389 | 50386850 |
Toxicity to various agents | 575.66 | 11.45 | 82 | 201803 | 212417 | 50190822 |
Lumbar vertebral fracture | 565.36 | 11.45 | 303 | 201582 | 4294 | 50398945 |
Maternal exposure during pregnancy | 516.65 | 11.45 | 30 | 201855 | 159748 | 50243491 |
Metastases to bone | 511.85 | 11.45 | 484 | 201401 | 17511 | 50385728 |
Completed suicide | 508.34 | 11.45 | 3 | 201882 | 131886 | 50271353 |
Spinal compression fracture | 484.89 | 11.45 | 403 | 201482 | 12253 | 50390986 |
Dental implantation | 482.58 | 11.45 | 153 | 201732 | 459 | 50402780 |
Blood parathyroid hormone increased | 475.83 | 11.45 | 231 | 201654 | 2623 | 50400616 |
Jaw disorder | 474.83 | 11.45 | 277 | 201608 | 4666 | 50398573 |
Exposed bone in jaw | 473.97 | 11.45 | 229 | 201656 | 2571 | 50400668 |
Dental care | 468.38 | 11.45 | 166 | 201719 | 766 | 50402473 |
Exposure during pregnancy | 460.18 | 11.45 | 4 | 201881 | 121011 | 50282228 |
Groin pain | 457.42 | 11.45 | 337 | 201548 | 8554 | 50394685 |
Drug intolerance | 447.10 | 11.45 | 158 | 201727 | 218946 | 50184293 |
Tooth loss | 442.70 | 11.45 | 287 | 201598 | 5883 | 50397356 |
Pemphigus | 435.16 | 11.45 | 9 | 201876 | 120157 | 50283082 |
Hip fracture | 428.41 | 11.45 | 523 | 201362 | 25408 | 50377831 |
Drug interaction | 424.64 | 11.45 | 134 | 201751 | 199487 | 50203752 |
Infusion related reaction | 424.40 | 11.45 | 81 | 201804 | 169476 | 50233763 |
Femur fracture | 423.53 | 11.45 | 628 | 201257 | 36836 | 50366403 |
Contraindicated product administered | 413.88 | 11.45 | 53 | 201832 | 148905 | 50254334 |
Treatment failure | 399.77 | 11.45 | 42 | 201843 | 137595 | 50265644 |
Synovitis | 398.10 | 11.45 | 24 | 201861 | 123841 | 50279398 |
Pathological fracture | 392.55 | 11.45 | 290 | 201595 | 7392 | 50395847 |
Condition aggravated | 382.54 | 11.45 | 373 | 201512 | 296685 | 50106554 |
Musculoskeletal pain | 378.55 | 11.45 | 868 | 201017 | 71309 | 50331930 |
Systemic lupus erythematosus | 360.86 | 11.45 | 63 | 201822 | 140559 | 50262680 |
Terminal state | 346.41 | 11.45 | 169 | 201716 | 1941 | 50401298 |
Drug hypersensitivity | 343.43 | 11.45 | 298 | 201587 | 250712 | 50152527 |
Bone loss | 342.33 | 11.45 | 181 | 201704 | 2491 | 50400748 |
Product use issue | 327.44 | 11.45 | 95 | 201790 | 149380 | 50253859 |
Breast cancer metastatic | 314.44 | 11.45 | 289 | 201596 | 10075 | 50393164 |
Loose tooth | 309.19 | 11.45 | 181 | 201704 | 3069 | 50400170 |
Acute kidney injury | 298.48 | 11.45 | 282 | 201603 | 227776 | 50175463 |
Joint swelling | 285.48 | 11.45 | 335 | 201550 | 244951 | 50158288 |
Glossodynia | 285.30 | 11.45 | 57 | 201828 | 115512 | 50287727 |
Hypotension | 284.47 | 11.45 | 312 | 201573 | 235157 | 50168082 |
Exostosis of jaw | 282.49 | 11.45 | 124 | 201761 | 1095 | 50402144 |
Therapeutic product effect decreased | 279.22 | 11.45 | 97 | 201788 | 135953 | 50267286 |
Hepatic enzyme increased | 275.06 | 11.45 | 102 | 201783 | 137278 | 50265961 |
Incorrect route of product administration | 274.09 | 11.45 | 355 | 201530 | 18311 | 50384928 |
Vomiting | 272.48 | 11.45 | 936 | 200949 | 459822 | 49943417 |
Hospitalisation | 257.93 | 11.45 | 723 | 201162 | 67214 | 50336025 |
Blood calcium decreased | 255.68 | 11.45 | 362 | 201523 | 20344 | 50382895 |
Hand deformity | 254.59 | 11.45 | 46 | 201839 | 100153 | 50303086 |
Dental caries | 249.78 | 11.45 | 249 | 201636 | 9618 | 50393621 |
Osteomyelitis | 243 | 11.45 | 368 | 201517 | 21985 | 50381254 |
Overdose | 240.34 | 11.45 | 52 | 201833 | 99675 | 50303564 |
Metastases to liver | 240.19 | 11.45 | 346 | 201539 | 19758 | 50383481 |
Intentional overdose | 233.24 | 11.45 | 3 | 201882 | 62501 | 50340738 |
Product use in unapproved indication | 228.46 | 11.45 | 88 | 201797 | 115731 | 50287508 |
Somnolence | 228.01 | 11.45 | 171 | 201714 | 154814 | 50248425 |
Atypical fracture | 224.56 | 11.45 | 86 | 201799 | 513 | 50402726 |
Drug abuse | 222.76 | 11.45 | 3 | 201882 | 59843 | 50343396 |
Abdominal discomfort | 221.76 | 11.45 | 364 | 201521 | 231277 | 50171962 |
Pericarditis | 216.05 | 11.45 | 29 | 201856 | 78660 | 50324579 |
Foot fracture | 214.49 | 11.45 | 328 | 201557 | 19763 | 50383476 |
Wound | 210.97 | 11.45 | 79 | 201806 | 105715 | 50297524 |
Neoplasm progression | 210.57 | 11.45 | 400 | 201485 | 28757 | 50374482 |
Rheumatoid arthritis | 209.46 | 11.45 | 302 | 201583 | 202248 | 50200991 |
Eczema | 204.48 | 11.45 | 343 | 201542 | 22359 | 50380880 |
Investigation | 204.13 | 11.45 | 107 | 201778 | 1445 | 50401794 |
Dyspnoea | 204.02 | 11.45 | 1315 | 200570 | 546293 | 49856946 |
Mobility decreased | 202.19 | 11.45 | 740 | 201145 | 79208 | 50324031 |
Blood calcium increased | 201.33 | 11.45 | 198 | 201687 | 7521 | 50395718 |
Confusional state | 199.44 | 11.45 | 270 | 201615 | 185658 | 50217581 |
Product storage error | 197.73 | 11.45 | 244 | 201641 | 11980 | 50391259 |
Bone disorder | 197.17 | 11.45 | 304 | 201581 | 18448 | 50384791 |
Endodontic procedure | 190.30 | 11.45 | 125 | 201760 | 2621 | 50400618 |
Swelling | 189.10 | 11.45 | 319 | 201566 | 200553 | 50202686 |
Muscle spasms | 188.05 | 11.45 | 993 | 200892 | 124560 | 50278679 |
Compression fracture | 185.35 | 11.45 | 167 | 201718 | 5670 | 50397569 |
Nausea | 184.98 | 11.45 | 1863 | 200022 | 703535 | 49699704 |
Jaw operation | 179.63 | 11.45 | 79 | 201806 | 701 | 50402538 |
Rheumatoid factor positive | 179.38 | 11.45 | 4 | 201881 | 49855 | 50353384 |
Multiple fractures | 176.95 | 11.45 | 172 | 201713 | 6439 | 50396800 |
Weight increased | 171.88 | 11.45 | 341 | 201544 | 201550 | 50201689 |
Gingival pain | 169.71 | 11.45 | 161 | 201724 | 5845 | 50397394 |
Headache | 167.04 | 11.45 | 1260 | 200625 | 505275 | 49897964 |
Temporomandibular joint syndrome | 166.13 | 11.45 | 127 | 201758 | 3412 | 50399827 |
Helicobacter infection | 164.69 | 11.45 | 8 | 201877 | 49694 | 50353545 |
Tooth abscess | 163.46 | 11.45 | 228 | 201657 | 12632 | 50390607 |
Seizure | 160.89 | 11.45 | 140 | 201745 | 117734 | 50285505 |
Suicide attempt | 160.34 | 11.45 | 12 | 201873 | 51720 | 50351519 |
Blood calcium abnormal | 157.62 | 11.45 | 80 | 201805 | 1006 | 50402233 |
Gingival disorder | 157.05 | 11.45 | 118 | 201767 | 3087 | 50400152 |
Duodenal ulcer perforation | 155.57 | 11.45 | 6 | 201879 | 45605 | 50357634 |
Malignant neoplasm progression | 154.43 | 11.45 | 609 | 201276 | 67515 | 50335724 |
Bradycardia | 154.37 | 11.45 | 34 | 201851 | 64392 | 50338847 |
Cardiac arrest | 153.01 | 11.45 | 71 | 201814 | 83580 | 50319659 |
Osteonecrosis | 150.49 | 11.45 | 299 | 201586 | 22218 | 50381021 |
Tooth infection | 148.67 | 11.45 | 229 | 201656 | 13883 | 50389356 |
Intentional product use issue | 145.85 | 11.45 | 62 | 201823 | 76856 | 50326383 |
Wrist fracture | 145.02 | 11.45 | 203 | 201682 | 11284 | 50391955 |
Pyrexia | 144.33 | 11.45 | 907 | 200978 | 379296 | 50023943 |
Artificial crown procedure | 143.52 | 11.45 | 50 | 201835 | 217 | 50403022 |
Dental operation | 142.74 | 11.45 | 75 | 201810 | 1018 | 50402221 |
Pneumonia | 142.45 | 11.45 | 905 | 200980 | 377496 | 50025743 |
Abortion spontaneous | 137.52 | 11.45 | 7 | 201878 | 41765 | 50361474 |
Pelvic fracture | 135.74 | 11.45 | 197 | 201688 | 11323 | 50391916 |
Gingivitis | 135.26 | 11.45 | 156 | 201729 | 7128 | 50396111 |
Spinal pain | 133.55 | 11.45 | 189 | 201696 | 10614 | 50392625 |
Cystitis | 133.07 | 11.45 | 436 | 201449 | 44128 | 50359111 |
Tetany | 132.76 | 11.45 | 82 | 201803 | 1539 | 50401700 |
Coma | 132.33 | 11.45 | 32 | 201853 | 56847 | 50346392 |
Hyperaesthesia teeth | 132.16 | 11.45 | 80 | 201805 | 1446 | 50401793 |
Gingival recession | 130.88 | 11.45 | 75 | 201810 | 1219 | 50402020 |
Hypersensitivity | 130.21 | 11.45 | 432 | 201453 | 214729 | 50188510 |
Sinusitis | 129.44 | 11.45 | 307 | 201578 | 170251 | 50232988 |
Abdominal pain | 128.54 | 11.45 | 496 | 201389 | 235732 | 50167507 |
Tachycardia | 128.42 | 11.45 | 125 | 201760 | 99638 | 50303601 |
Bedridden | 128.00 | 11.45 | 172 | 201713 | 9195 | 50394044 |
Suicidal ideation | 127.21 | 11.45 | 32 | 201853 | 55353 | 50347886 |
Dental restoration failure | 125.23 | 11.45 | 56 | 201829 | 519 | 50402720 |
Cardio-respiratory arrest | 124.05 | 11.45 | 31 | 201854 | 53861 | 50349378 |
Depressed level of consciousness | 123.29 | 11.45 | 28 | 201857 | 51925 | 50351314 |
Folliculitis | 121.84 | 11.45 | 9 | 201876 | 39216 | 50364023 |
Oxygen saturation decreased | 120.89 | 11.45 | 71 | 201814 | 73177 | 50330062 |
Muscle injury | 119.74 | 11.45 | 7 | 201878 | 37104 | 50366135 |
Stress fracture | 118.95 | 11.45 | 142 | 201743 | 6733 | 50396506 |
Hyponatraemia | 118.56 | 11.45 | 125 | 201760 | 96014 | 50307225 |
Abscess jaw | 117.11 | 11.45 | 71 | 201814 | 1287 | 50401952 |
Lower limb fracture | 116.17 | 11.45 | 206 | 201679 | 14040 | 50389199 |
Lactic acidosis | 115.09 | 11.45 | 4 | 201881 | 33351 | 50369888 |
Inappropriate schedule of product administration | 112.90 | 11.45 | 576 | 201309 | 71255 | 50331984 |
Breast cancer | 110.91 | 11.45 | 400 | 201485 | 42490 | 50360749 |
Respiratory failure | 110.83 | 11.45 | 120 | 201765 | 91061 | 50312178 |
Gingival swelling | 109.65 | 11.45 | 103 | 201782 | 3692 | 50399547 |
Febrile neutropenia | 109.60 | 11.45 | 137 | 201748 | 97530 | 50305709 |
Rib fracture | 109.45 | 11.45 | 239 | 201646 | 18982 | 50384257 |
Multiple sclerosis relapse | 108.49 | 11.45 | 20 | 201865 | 42944 | 50360295 |
Lower respiratory tract infection | 108.45 | 11.45 | 132 | 201753 | 95069 | 50308170 |
Metastases to lung | 108.00 | 11.45 | 173 | 201712 | 10847 | 50392392 |
Hypoglycaemia | 105.13 | 11.45 | 41 | 201844 | 53540 | 50349699 |
Periodontitis | 103.79 | 11.45 | 91 | 201794 | 2978 | 50400261 |
Agitation | 102.86 | 11.45 | 42 | 201843 | 53342 | 50349897 |
Psoriatic arthropathy | 100.88 | 11.45 | 31 | 201854 | 47001 | 50356238 |
Musculoskeletal discomfort | 97.36 | 11.45 | 196 | 201689 | 14702 | 50388537 |
Dehydration | 97.12 | 11.45 | 299 | 201586 | 152150 | 50251089 |
International normalised ratio increased | 97.06 | 11.45 | 26 | 201859 | 43126 | 50360113 |
Vitamin D decreased | 96.50 | 11.45 | 142 | 201743 | 8264 | 50394975 |
Syncope | 95.51 | 11.45 | 165 | 201720 | 102837 | 50300402 |
Diarrhoea | 95.15 | 11.45 | 1715 | 200170 | 586761 | 49816478 |
Body height decreased | 94.46 | 11.45 | 145 | 201740 | 8763 | 50394476 |
Rash pruritic | 92.93 | 11.45 | 408 | 201477 | 47438 | 50355801 |
Unresponsive to stimuli | 92.34 | 11.45 | 8 | 201877 | 30601 | 50372638 |
C-telopeptide increased | 92.11 | 11.45 | 22 | 201863 | 9 | 50403230 |
Tumour marker increased | 91.87 | 11.45 | 94 | 201791 | 3746 | 50399493 |
Osteitis | 91.42 | 11.45 | 84 | 201801 | 2926 | 50400313 |
Dermatitis | 91.36 | 11.45 | 186 | 201699 | 14065 | 50389174 |
Metabolic acidosis | 88.07 | 11.45 | 23 | 201862 | 38802 | 50364437 |
Mastication disorder | 87.86 | 11.45 | 67 | 201818 | 1793 | 50401446 |
Neoplasm malignant | 87.60 | 11.45 | 250 | 201635 | 23465 | 50379774 |
Infection | 87.19 | 11.45 | 374 | 201511 | 172580 | 50230659 |
Sequestrectomy | 87.13 | 11.45 | 49 | 201836 | 767 | 50402472 |
Anaphylactic reaction | 86.94 | 11.45 | 54 | 201831 | 54001 | 50349238 |
Osteoporotic fracture | 86.38 | 11.45 | 83 | 201802 | 3062 | 50400177 |
Gastrointestinal haemorrhage | 86.35 | 11.45 | 99 | 201786 | 73222 | 50330017 |
Serotonin syndrome | 85.14 | 11.45 | 3 | 201882 | 24710 | 50378529 |
Influenza like illness | 84.92 | 11.45 | 453 | 201432 | 57006 | 50346233 |
Hypoxia | 83.72 | 11.45 | 50 | 201835 | 51073 | 50352166 |
Upper limb fracture | 82.13 | 11.45 | 190 | 201695 | 15683 | 50387556 |
Blood pressure decreased | 81.73 | 11.45 | 62 | 201823 | 55847 | 50347392 |
Dental cleaning | 81.64 | 11.45 | 21 | 201864 | 19 | 50403220 |
Loss of consciousness | 81.39 | 11.45 | 185 | 201700 | 104168 | 50299071 |
Multiple organ dysfunction syndrome | 81.35 | 11.45 | 50 | 201835 | 50287 | 50352952 |
Hypercalcaemia | 81.28 | 11.45 | 241 | 201644 | 23111 | 50380128 |
Fall | 81.06 | 11.45 | 1826 | 200059 | 333106 | 50070133 |
Encephalopathy | 80.32 | 11.45 | 18 | 201867 | 33693 | 50369546 |
Respiratory arrest | 80.14 | 11.45 | 12 | 201873 | 29997 | 50373242 |
Arthropathy | 79.87 | 11.45 | 341 | 201544 | 157565 | 50245674 |
No adverse event | 79.86 | 11.45 | 18 | 201867 | 33560 | 50369679 |
Sleep disorder due to a general medical condition | 79.59 | 11.45 | 121 | 201764 | 7250 | 50395989 |
C-reactive protein abnormal | 79.36 | 11.45 | 9 | 201876 | 27800 | 50375439 |
Osteonecrosis of external auditory canal | 79.09 | 11.45 | 25 | 201860 | 74 | 50403165 |
Intentional self-injury | 78.95 | 11.45 | 3 | 201882 | 23109 | 50380130 |
Alanine aminotransferase increased | 78.80 | 11.45 | 145 | 201740 | 88214 | 50315025 |
Chest discomfort | 78.47 | 11.45 | 157 | 201728 | 92565 | 50310674 |
Nasopharyngitis | 77.33 | 11.45 | 452 | 201433 | 192475 | 50210764 |
Wheezing | 77.24 | 11.45 | 80 | 201805 | 61967 | 50341272 |
Metastases to lymph nodes | 76.83 | 11.45 | 116 | 201769 | 6908 | 50396331 |
Dry skin | 76.18 | 11.45 | 358 | 201527 | 42833 | 50360406 |
Anxiety | 76.13 | 11.45 | 407 | 201478 | 177199 | 50226040 |
Foetal exposure during pregnancy | 75.27 | 11.45 | 10 | 201875 | 27349 | 50375890 |
Carbohydrate antigen 15-3 increased | 74.74 | 11.45 | 50 | 201835 | 1082 | 50402157 |
Hyperparathyroidism | 74.55 | 11.45 | 68 | 201817 | 2346 | 50400893 |
Irritable bowel syndrome | 73.98 | 11.45 | 58 | 201827 | 51383 | 50351856 |
Metastases to spine | 72.68 | 11.45 | 72 | 201813 | 2759 | 50400480 |
Joint noise | 72.01 | 11.45 | 80 | 201805 | 3507 | 50399732 |
Chest pain | 71.63 | 11.45 | 413 | 201472 | 176469 | 50226770 |
Discomfort | 71.56 | 11.45 | 209 | 201676 | 108171 | 50295068 |
Injection site erythema | 71.34 | 11.45 | 118 | 201767 | 74818 | 50328421 |
Type 2 diabetes mellitus | 71.34 | 11.45 | 24 | 201861 | 34351 | 50368888 |
Gingival abscess | 71.19 | 11.45 | 41 | 201844 | 673 | 50402566 |
Tooth erosion | 70.68 | 11.45 | 35 | 201850 | 416 | 50402823 |
Mental status changes | 69.12 | 11.45 | 29 | 201856 | 36243 | 50366996 |
Incorrect dose administered | 69.11 | 11.45 | 55 | 201830 | 48359 | 50354880 |
PIK3CA-activated mutation | 68.95 | 11.45 | 42 | 201843 | 768 | 50402471 |
Hyperkalaemia | 68.18 | 11.45 | 55 | 201830 | 48034 | 50355205 |
Renal failure | 67.98 | 11.45 | 209 | 201676 | 106424 | 50296815 |
Pancytopenia | 67.96 | 11.45 | 146 | 201739 | 83884 | 50319355 |
Sedation | 67.79 | 11.45 | 19 | 201866 | 30591 | 50372648 |
Drug withdrawal syndrome | 67.05 | 11.45 | 10 | 201875 | 25071 | 50378168 |
Dental necrosis | 66.15 | 11.45 | 24 | 201861 | 120 | 50403119 |
Aspartate aminotransferase increased | 66.05 | 11.45 | 132 | 201753 | 77866 | 50325373 |
Oedema | 65.43 | 11.45 | 112 | 201773 | 70069 | 50333170 |
Flushing | 65.22 | 11.45 | 104 | 201781 | 66911 | 50336328 |
Oedema peripheral | 64.39 | 11.45 | 368 | 201517 | 157593 | 50245646 |
Premature delivery | 64.27 | 11.45 | 9 | 201876 | 23654 | 50379585 |
Sepsis | 64.21 | 11.45 | 292 | 201593 | 132633 | 50270606 |
Drug reaction with eosinophilia and systemic symptoms | 64.16 | 11.45 | 17 | 201868 | 28407 | 50374832 |
Fatigue | 64.04 | 11.45 | 2247 | 199638 | 705354 | 49697885 |
Jaw fistula | 63.74 | 11.45 | 19 | 201866 | 43 | 50403196 |
Heart rate decreased | 63.65 | 11.45 | 33 | 201852 | 36464 | 50366775 |
Blood parathyroid hormone abnormal | 63.56 | 11.45 | 26 | 201859 | 189 | 50403050 |
Product quality issue | 63.25 | 11.45 | 22 | 201863 | 30836 | 50372403 |
Emotional distress | 63.09 | 11.45 | 18 | 201867 | 28645 | 50374594 |
Fractured sacrum | 62.19 | 11.45 | 54 | 201831 | 1744 | 50401495 |
Tremor | 61.92 | 11.45 | 242 | 201643 | 114661 | 50288578 |
Delirium | 61.63 | 11.45 | 38 | 201847 | 38154 | 50365085 |
Peripheral swelling | 61.23 | 11.45 | 526 | 201359 | 205410 | 50197829 |
Blood pressure increased | 61.04 | 11.45 | 298 | 201587 | 132834 | 50270405 |
Therapeutic response decreased | 60.96 | 11.45 | 59 | 201826 | 47172 | 50356067 |
Psoriasis | 60.84 | 11.45 | 114 | 201771 | 68886 | 50334353 |
Sinus tachycardia | 60.71 | 11.45 | 7 | 201878 | 21347 | 50381892 |
Metastases to central nervous system | 60.53 | 11.45 | 137 | 201748 | 11145 | 50392094 |
Asthma | 59.91 | 11.45 | 171 | 201714 | 89166 | 50314073 |
Toxic epidermal necrolysis | 59.39 | 11.45 | 7 | 201878 | 20985 | 50382254 |
Femoral neck fracture | 59.39 | 11.45 | 107 | 201778 | 7383 | 50395856 |
Rhabdomyolysis | 58.70 | 11.45 | 42 | 201843 | 38985 | 50364254 |
Hospice care | 58.47 | 11.45 | 92 | 201793 | 5680 | 50397559 |
Vitamin D abnormal | 58.33 | 11.45 | 22 | 201863 | 125 | 50403114 |
Migraine | 58.25 | 11.45 | 134 | 201751 | 75146 | 50328093 |
Hallucination | 58.25 | 11.45 | 60 | 201825 | 46597 | 50356642 |
Drug level increased | 58.22 | 11.45 | 5 | 201880 | 19263 | 50383976 |
Cardiac failure congestive | 57.70 | 11.45 | 160 | 201725 | 84222 | 50319017 |
Injection site reaction | 57.35 | 11.45 | 69 | 201816 | 49963 | 50353276 |
Hypophosphataemia | 56.54 | 11.45 | 112 | 201773 | 8302 | 50394937 |
Septic shock | 56.33 | 11.45 | 88 | 201797 | 57087 | 50346152 |
Immobile | 56.04 | 11.45 | 84 | 201801 | 4970 | 50398269 |
Spinal deformity | 55.56 | 11.45 | 39 | 201846 | 915 | 50402324 |
Pulpitis dental | 55.50 | 11.45 | 37 | 201848 | 796 | 50402443 |
Psychotic disorder | 55.40 | 11.45 | 10 | 201875 | 21802 | 50381437 |
Living in residential institution | 55.23 | 11.45 | 30 | 201855 | 437 | 50402802 |
Paraesthesia | 54.70 | 11.45 | 726 | 201159 | 119517 | 50283722 |
Product dose omission issue | 53.77 | 11.45 | 1031 | 200854 | 182807 | 50220432 |
Polymyalgia rheumatica | 53.28 | 11.45 | 59 | 201826 | 2577 | 50400662 |
Liver function test abnormal | 53.14 | 11.45 | 59 | 201826 | 44280 | 50358959 |
Haemoglobin decreased | 53.12 | 11.45 | 294 | 201591 | 126922 | 50276317 |
Tooth resorption | 52.85 | 11.45 | 16 | 201869 | 39 | 50403200 |
Dysarthria | 52.74 | 11.45 | 43 | 201842 | 37360 | 50365879 |
Orthostatic hypotension | 52.39 | 11.45 | 26 | 201859 | 29455 | 50373784 |
Dental discomfort | 52.34 | 11.45 | 27 | 201858 | 352 | 50402887 |
Fluid retention | 51.78 | 11.45 | 76 | 201809 | 50573 | 50352666 |
Depression | 51.20 | 11.45 | 418 | 201467 | 165005 | 50238234 |
Impaired healing | 50.99 | 11.45 | 463 | 201422 | 69323 | 50333916 |
Musculoskeletal stiffness | 50.92 | 11.45 | 302 | 201583 | 128179 | 50275060 |
C-reactive protein increased | 50.89 | 11.45 | 119 | 201766 | 66355 | 50336884 |
Cognitive disorder | 50.41 | 11.45 | 61 | 201824 | 44062 | 50359177 |
Dental fistula | 50.37 | 11.45 | 31 | 201854 | 578 | 50402661 |
Liver injury | 50.30 | 11.45 | 18 | 201867 | 24788 | 50378451 |
Generalised tonic-clonic seizure | 50.19 | 11.45 | 21 | 201864 | 26289 | 50376950 |
Sciatica | 49.91 | 11.45 | 193 | 201692 | 21189 | 50382050 |
Blood glucose increased | 49.69 | 11.45 | 134 | 201751 | 71190 | 50332049 |
Anaemia | 49.14 | 11.45 | 710 | 201175 | 251746 | 50151493 |
Tibia fracture | 49.08 | 11.45 | 74 | 201811 | 4401 | 50398838 |
Metastases to skin | 48.77 | 11.45 | 42 | 201843 | 1341 | 50401898 |
Injury | 48.49 | 11.45 | 75 | 201810 | 48850 | 50354389 |
Jaw fracture | 48.15 | 11.45 | 54 | 201831 | 2392 | 50400847 |
Muscle spasticity | 47.95 | 11.45 | 6 | 201879 | 17178 | 50386061 |
Neck pain | 47.66 | 11.45 | 390 | 201495 | 56677 | 50346562 |
Dizziness | 47.42 | 11.45 | 1037 | 200848 | 345332 | 50057907 |
Heart rate increased | 47.41 | 11.45 | 154 | 201731 | 77096 | 50326143 |
Parathyroidectomy | 47.31 | 11.45 | 22 | 201863 | 225 | 50403014 |
Stevens-Johnson syndrome | 47.25 | 11.45 | 14 | 201871 | 21738 | 50381501 |
Scoliosis | 47.19 | 11.45 | 90 | 201795 | 6486 | 50396753 |
Hyperhidrosis | 47.12 | 11.45 | 190 | 201695 | 89236 | 50314003 |
Oral pain | 46.73 | 11.45 | 211 | 201674 | 24822 | 50378417 |
Blood phosphorus decreased | 46.40 | 11.45 | 66 | 201819 | 3723 | 50399516 |
Humerus fracture | 45.98 | 11.45 | 97 | 201788 | 7521 | 50395718 |
Blister | 45.95 | 11.45 | 180 | 201705 | 85238 | 50318001 |
Right ventricular failure | 45.71 | 11.45 | 5 | 201880 | 15888 | 50387351 |
Menopausal symptoms | 45.27 | 11.45 | 48 | 201837 | 1995 | 50401244 |
Injection site pruritus | 44.98 | 11.45 | 57 | 201828 | 40354 | 50362885 |
Parathyroid disorder | 44.85 | 11.45 | 28 | 201857 | 536 | 50402703 |
Adverse reaction | 44.66 | 11.45 | 103 | 201782 | 8483 | 50394756 |
Pulmonary arterial hypertension | 44.28 | 11.45 | 13 | 201872 | 20306 | 50382933 |
Traumatic fracture | 43.86 | 11.45 | 28 | 201857 | 558 | 50402681 |
Hypervolaemia | 43.08 | 11.45 | 24 | 201861 | 25475 | 50377764 |
Device dislocation | 43.07 | 11.45 | 16 | 201869 | 21530 | 50381709 |
Gait disturbance | 42.73 | 11.45 | 838 | 201047 | 149167 | 50254072 |
White blood cell count increased | 42.58 | 11.45 | 64 | 201821 | 42176 | 50361063 |
Red blood cell sedimentation rate increased | 42.50 | 11.45 | 33 | 201852 | 29383 | 50373856 |
Drug dependence | 42.41 | 11.45 | 13 | 201872 | 19746 | 50383493 |
Eosinophilia | 42.39 | 11.45 | 11 | 201874 | 18641 | 50384598 |
Caesarean section | 42.35 | 11.45 | 6 | 201879 | 15633 | 50387606 |
Bronchitis | 42.24 | 11.45 | 243 | 201642 | 103916 | 50299323 |
Medication error | 42.22 | 11.45 | 49 | 201836 | 36055 | 50367184 |
Status epilepticus | 41.85 | 11.45 | 3 | 201882 | 13403 | 50389836 |
Product substitution issue | 41.52 | 11.45 | 4 | 201881 | 14053 | 50389186 |
Haematemesis | 41.48 | 11.45 | 30 | 201855 | 27695 | 50375544 |
Prescribed overdose | 40.98 | 11.45 | 5 | 201880 | 14595 | 50388644 |
Hand fracture | 40.88 | 11.45 | 68 | 201817 | 4400 | 50398839 |
Drug ineffective for unapproved indication | 40.57 | 11.45 | 17 | 201868 | 21264 | 50381975 |
Dental prosthesis placement | 40.51 | 11.45 | 14 | 201871 | 59 | 50403180 |
Mouth swelling | 40.48 | 11.45 | 63 | 201822 | 3853 | 50399386 |
Oral surgery | 40.40 | 11.45 | 33 | 201852 | 978 | 50402261 |
Aggression | 40.04 | 11.45 | 17 | 201868 | 21099 | 50382140 |
Parathyroid tumour | 39.99 | 11.45 | 16 | 201869 | 109 | 50403130 |
Haematochezia | 39.65 | 11.45 | 61 | 201824 | 39821 | 50363418 |
Osteoporosis | 39.26 | 11.45 | 310 | 201575 | 44569 | 50358670 |
Deep vein thrombosis | 39.09 | 11.45 | 155 | 201730 | 73149 | 50330090 |
Device failure | 38.86 | 11.45 | 75 | 201810 | 5453 | 50397786 |
Staphylococcal infection | 38.85 | 11.45 | 51 | 201834 | 35565 | 50367674 |
Nasal congestion | 38.74 | 11.45 | 92 | 201793 | 51028 | 50352211 |
Musculoskeletal chest pain | 38.47 | 11.45 | 161 | 201724 | 18325 | 50384914 |
Noninfective gingivitis | 38.29 | 11.45 | 35 | 201850 | 1211 | 50402028 |
Cytomegalovirus infection | 38.22 | 11.45 | 12 | 201873 | 17950 | 50385289 |
Oral infection | 38.16 | 11.45 | 63 | 201822 | 4051 | 50399188 |
Spinal operation | 38.12 | 11.45 | 80 | 201805 | 6180 | 50397059 |
Vitamin D deficiency | 38.09 | 11.45 | 116 | 201769 | 11286 | 50391953 |
Dyskinesia | 38.09 | 11.45 | 33 | 201852 | 27828 | 50375411 |
Blood alkaline phosphatase decreased | 37.92 | 11.45 | 33 | 201852 | 1069 | 50402170 |
Infusion site pain | 37.86 | 11.45 | 3 | 201882 | 12343 | 50390896 |
Abdominal lymphadenopathy | 37.72 | 11.45 | 27 | 201858 | 654 | 50402585 |
Blood pressure fluctuation | 37.36 | 11.45 | 53 | 201832 | 35770 | 50367469 |
Coronary artery disease | 37.36 | 11.45 | 38 | 201847 | 29688 | 50373551 |
Pulmonary hypertension | 37.33 | 11.45 | 47 | 201838 | 33370 | 50369869 |
Irritability | 37.27 | 11.45 | 35 | 201850 | 28391 | 50374848 |
Body temperature increased | 37.23 | 11.45 | 42 | 201843 | 31299 | 50371940 |
Walking aid user | 36.63 | 11.45 | 80 | 201805 | 6353 | 50396886 |
Circulatory collapse | 36.51 | 11.45 | 17 | 201868 | 19983 | 50383256 |
Disorientation | 36.51 | 11.45 | 53 | 201832 | 35431 | 50367808 |
Oestrogen deficiency | 36.28 | 11.45 | 16 | 201869 | 143 | 50403096 |
Bone resorption test abnormal | 36.18 | 11.45 | 9 | 201876 | 6 | 50403233 |
Hyperparathyroidism secondary | 35.89 | 11.45 | 35 | 201850 | 1315 | 50401924 |
Poisoning | 35.52 | 11.45 | 4 | 201881 | 12425 | 50390814 |
Acute respiratory distress syndrome | 35.44 | 11.45 | 20 | 201865 | 21079 | 50382160 |
Drug-induced liver injury | 35.21 | 11.45 | 36 | 201849 | 28059 | 50375180 |
Hemiparesis | 35.14 | 11.45 | 18 | 201867 | 20030 | 50383209 |
Product prescribing error | 35.02 | 11.45 | 20 | 201865 | 20941 | 50382298 |
Trismus | 34.80 | 11.45 | 54 | 201831 | 3294 | 50399945 |
Abdominal pain upper | 34.59 | 11.45 | 438 | 201447 | 158871 | 50244368 |
Cyanosis | 34.42 | 11.45 | 9 | 201876 | 15175 | 50388064 |
Hypokalaemia | 34.23 | 11.45 | 208 | 201677 | 87784 | 50315455 |
Paraesthesia oral | 34.19 | 11.45 | 117 | 201768 | 12104 | 50391135 |
Haematoma | 33.99 | 11.45 | 43 | 201842 | 30467 | 50372772 |
Bone lesion | 33.75 | 11.45 | 68 | 201817 | 5102 | 50398137 |
Radius fracture | 33.69 | 11.45 | 52 | 201833 | 3157 | 50400082 |
Withdrawal syndrome | 33.62 | 11.45 | 14 | 201871 | 17576 | 50385663 |
Bronchospasm | 33.30 | 11.45 | 9 | 201876 | 14845 | 50388394 |
Pneumonia aspiration | 33.20 | 11.45 | 45 | 201840 | 30959 | 50372280 |
Extrapyramidal disorder | 33.11 | 11.45 | 4 | 201881 | 11766 | 50391473 |
Hypophosphatasia | 33.00 | 11.45 | 8 | 201877 | 4 | 50403235 |
Ventricular tachycardia | 32.91 | 11.45 | 11 | 201874 | 15810 | 50387429 |
Lichen planus | 32.80 | 11.45 | 40 | 201845 | 1939 | 50401300 |
Blood creatine phosphokinase increased | 32.80 | 11.45 | 34 | 201851 | 26333 | 50376906 |
Metastasis | 32.79 | 11.45 | 61 | 201824 | 4314 | 50398925 |
Vision blurred | 32.68 | 11.45 | 182 | 201703 | 78465 | 50324774 |
Haematocrit decreased | 32.43 | 11.45 | 56 | 201829 | 34920 | 50368319 |
Obstructive airways disorder | 32.35 | 11.45 | 11 | 201874 | 15641 | 50387598 |
Respiratory distress | 31.90 | 11.45 | 45 | 201840 | 30444 | 50372795 |
Immune system disorder | 31.69 | 11.45 | 88 | 201797 | 8129 | 50395110 |
Coagulopathy | 31.62 | 11.45 | 16 | 201869 | 17928 | 50385311 |
Sinus bradycardia | 31.48 | 11.45 | 7 | 201878 | 13176 | 50390063 |
Palpitations | 31.46 | 11.45 | 234 | 201651 | 94272 | 50308967 |
Rash papular | 31.26 | 11.45 | 116 | 201769 | 12488 | 50390751 |
Pancreatitis | 31.26 | 11.45 | 78 | 201807 | 42536 | 50360703 |
Atrial fibrillation | 31.04 | 11.45 | 258 | 201627 | 101487 | 50301752 |
Disease recurrence | 31.00 | 11.45 | 21 | 201864 | 20060 | 50383179 |
Adverse drug reaction | 30.99 | 11.45 | 347 | 201538 | 54875 | 50348364 |
Blood bilirubin increased | 30.90 | 11.45 | 50 | 201835 | 31988 | 50371251 |
Bone marrow failure | 30.70 | 11.45 | 39 | 201846 | 27585 | 50375654 |
Acute myeloid leukaemia | 30.46 | 11.45 | 11 | 201874 | 15063 | 50388176 |
Pancreatitis acute | 30.43 | 11.45 | 30 | 201855 | 23782 | 50379457 |
Paranoia | 30.42 | 11.45 | 3 | 201882 | 10345 | 50392894 |
Ear pain | 30.26 | 11.45 | 205 | 201680 | 28078 | 50375161 |
Oral cavity fistula | 30.02 | 11.45 | 23 | 201862 | 620 | 50402619 |
Forearm fracture | 29.93 | 11.45 | 20 | 201865 | 432 | 50402807 |
Feeling abnormal | 29.87 | 11.45 | 683 | 201202 | 124809 | 50278430 |
Photophobia | 29.85 | 11.45 | 11 | 201874 | 14876 | 50388363 |
Abnormal behaviour | 29.76 | 11.45 | 21 | 201864 | 19637 | 50383602 |
Intentional product misuse | 29.48 | 11.45 | 92 | 201793 | 46642 | 50356597 |
Diabetes mellitus inadequate control | 29.40 | 11.45 | 8 | 201877 | 13137 | 50390102 |
Respiratory rate increased | 29.39 | 11.45 | 5 | 201880 | 11380 | 50391859 |
Myocardial infarction | 29.36 | 11.45 | 221 | 201664 | 88806 | 50314433 |
Tubulointerstitial nephritis | 29.24 | 11.45 | 12 | 201873 | 15199 | 50388040 |
Pulmonary oedema | 29.03 | 11.45 | 99 | 201786 | 48839 | 50354400 |
Anuria | 28.89 | 11.45 | 5 | 201880 | 11239 | 50392000 |
Nightmare | 28.86 | 11.45 | 14 | 201871 | 16072 | 50387167 |
Denture wearer | 28.85 | 11.45 | 15 | 201870 | 199 | 50403040 |
Tachypnoea | 28.84 | 11.45 | 11 | 201874 | 14566 | 50388673 |
Acute respiratory failure | 28.63 | 11.45 | 44 | 201841 | 28738 | 50374501 |
Hepatic steatosis | 28.61 | 11.45 | 33 | 201852 | 24351 | 50378888 |
Hepatitis | 28.58 | 11.45 | 51 | 201834 | 31402 | 50371837 |
Myoclonus | 28.50 | 11.45 | 11 | 201874 | 14459 | 50388780 |
Unevaluable event | 28.42 | 11.45 | 295 | 201590 | 45771 | 50357468 |
Labelled drug-drug interaction medication error | 28.42 | 11.45 | 4 | 201881 | 10473 | 50392766 |
Gingival erythema | 28.40 | 11.45 | 22 | 201863 | 603 | 50402636 |
Bacteraemia | 28.38 | 11.45 | 11 | 201874 | 14422 | 50388817 |
Upper respiratory tract infection | 28.20 | 11.45 | 151 | 201734 | 65747 | 50337492 |
Accidental overdose | 28.11 | 11.45 | 22 | 201863 | 19511 | 50383728 |
Cough | 28.09 | 11.45 | 740 | 201145 | 240524 | 50162715 |
Blood creatinine increased | 28.09 | 11.45 | 183 | 201702 | 75977 | 50327262 |
Thrombocytopenia | 28.09 | 11.45 | 350 | 201535 | 127323 | 50275916 |
COVID-19 | 27.95 | 11.45 | 94 | 201791 | 46568 | 50356671 |
Gingival operation | 27.93 | 11.45 | 12 | 201873 | 100 | 50403139 |
Melaena | 27.76 | 11.45 | 40 | 201845 | 26824 | 50376415 |
Metastases to pleura | 27.73 | 11.45 | 30 | 201855 | 1276 | 50401963 |
Back disorder | 27.73 | 11.45 | 91 | 201794 | 9214 | 50394025 |
Vitamin D increased | 27.63 | 11.45 | 21 | 201864 | 559 | 50402680 |
Pneumocystis jirovecii pneumonia | 27.49 | 11.45 | 12 | 201873 | 14651 | 50388588 |
Periodontal disease | 27.47 | 11.45 | 32 | 201853 | 1478 | 50401761 |
Agranulocytosis | 27.36 | 11.45 | 27 | 201858 | 21394 | 50381845 |
Diabetic ketoacidosis | 27.18 | 11.45 | 19 | 201866 | 17853 | 50385386 |
Rash macular | 27.13 | 11.45 | 150 | 201735 | 19127 | 50384112 |
Hallucination, auditory | 27.07 | 11.45 | 5 | 201880 | 10723 | 50392516 |
Scab | 27.03 | 11.45 | 72 | 201813 | 6490 | 50396749 |
Contusion | 26.81 | 11.45 | 302 | 201583 | 111881 | 50291358 |
Bone graft | 26.80 | 11.45 | 24 | 201861 | 808 | 50402431 |
Onychoclasis | 26.66 | 11.45 | 62 | 201823 | 5134 | 50398105 |
Obesity | 26.63 | 11.45 | 17 | 201868 | 16758 | 50386481 |
Palliative care | 26.62 | 11.45 | 17 | 201868 | 339 | 50402900 |
Injury associated with device | 26.61 | 11.45 | 46 | 201839 | 3071 | 50400168 |
Haemoptysis | 26.50 | 11.45 | 38 | 201847 | 25535 | 50377704 |
Cardiogenic shock | 25.89 | 11.45 | 15 | 201870 | 15584 | 50387655 |
Intercepted medication error | 25.69 | 11.45 | 18 | 201867 | 421 | 50402818 |
Respiratory depression | 25.60 | 11.45 | 8 | 201877 | 12002 | 50391237 |
Cataract operation | 25.57 | 11.45 | 53 | 201832 | 4058 | 50399181 |
Exostosis | 25.44 | 11.45 | 103 | 201782 | 11550 | 50391689 |
Haemorrhage | 25.42 | 11.45 | 118 | 201767 | 53323 | 50349916 |
Drug resistance | 25.35 | 11.45 | 23 | 201862 | 18966 | 50384273 |
Oral discomfort | 25.33 | 11.45 | 80 | 201805 | 7937 | 50395302 |
Angioedema | 25.33 | 11.45 | 72 | 201813 | 37604 | 50365635 |
Acidosis | 25.31 | 11.45 | 5 | 201880 | 10222 | 50393017 |
Posterior reversible encephalopathy syndrome | 25.29 | 11.45 | 14 | 201871 | 14914 | 50388325 |
Renal tubular necrosis | 25.10 | 11.45 | 5 | 201880 | 10163 | 50393076 |
Sputum discoloured | 25.06 | 11.45 | 11 | 201874 | 13384 | 50389855 |
Injection site bruising | 24.91 | 11.45 | 70 | 201815 | 36698 | 50366541 |
Chemotherapy | 24.88 | 11.45 | 29 | 201856 | 1340 | 50401899 |
Hepatocellular injury | 24.55 | 11.45 | 41 | 201844 | 25906 | 50377333 |
Restlessness | 24.55 | 11.45 | 39 | 201846 | 25134 | 50378105 |
Disturbance in attention | 24.53 | 11.45 | 55 | 201830 | 31131 | 50372108 |
Bone density increased | 24.52 | 11.45 | 18 | 201867 | 454 | 50402785 |
Cholelithiasis | 24.49 | 11.45 | 74 | 201811 | 37899 | 50365340 |
Bone swelling | 24.31 | 11.45 | 27 | 201858 | 1183 | 50402056 |
Altered state of consciousness | 24.28 | 11.45 | 31 | 201854 | 21879 | 50381360 |
Inappropriate antidiuretic hormone secretion | 24.26 | 11.45 | 11 | 201874 | 13132 | 50390107 |
Dementia | 24.22 | 11.45 | 127 | 201758 | 15870 | 50387369 |
Prescribed underdose | 24.20 | 11.45 | 17 | 201868 | 15932 | 50387307 |
Hyperglycaemia | 24.16 | 11.45 | 70 | 201815 | 36335 | 50366904 |
Nerve compression | 24.08 | 11.45 | 75 | 201810 | 7387 | 50395852 |
Amnesia | 24.05 | 11.45 | 87 | 201798 | 42173 | 50361066 |
Renal injury | 24.04 | 11.45 | 3 | 201882 | 8608 | 50394631 |
Basal cell carcinoma | 23.92 | 11.45 | 35 | 201850 | 23321 | 50379918 |
Hypothermia | 23.89 | 11.45 | 9 | 201876 | 12007 | 50391232 |
Malpositioned teeth | 23.74 | 11.45 | 7 | 201878 | 15 | 50403224 |
Hypertension | 23.74 | 11.45 | 651 | 201234 | 210552 | 50192687 |
Blood creatinine abnormal | 23.71 | 11.45 | 40 | 201845 | 2618 | 50400621 |
Therapeutic product effect incomplete | 23.62 | 11.45 | 242 | 201643 | 91273 | 50311966 |
Wrong technique in product usage process | 23.52 | 11.45 | 331 | 201554 | 55179 | 50348060 |
Sleep disorder due to general medical condition, insomnia type | 23.50 | 11.45 | 57 | 201828 | 31390 | 50371849 |
Metaphyseal corner fracture | 23.48 | 11.45 | 8 | 201877 | 32 | 50403207 |
Calcinosis | 23.37 | 11.45 | 33 | 201852 | 1849 | 50401390 |
Electrocardiogram QT prolonged | 23.26 | 11.45 | 117 | 201768 | 51769 | 50351470 |
Ataxia | 23.25 | 11.45 | 13 | 201872 | 13773 | 50389466 |
Parathyroid tumour malignant | 23.14 | 11.45 | 7 | 201878 | 17 | 50403222 |
Metastases to peritoneum | 23.14 | 11.45 | 41 | 201844 | 2792 | 50400447 |
Affect lability | 23.12 | 11.45 | 4 | 201881 | 8994 | 50394245 |
Injection site swelling | 23.12 | 11.45 | 87 | 201798 | 41686 | 50361553 |
Shock haemorrhagic | 23.07 | 11.45 | 3 | 201882 | 8341 | 50394898 |
Pulmonary embolism | 23.05 | 11.45 | 277 | 201608 | 101427 | 50301812 |
Gingival cyst | 23.03 | 11.45 | 6 | 201879 | 6 | 50403233 |
Device fastener issue | 23.03 | 11.45 | 6 | 201879 | 6 | 50403233 |
Bone cancer | 23.02 | 11.45 | 26 | 201859 | 1161 | 50402078 |
Leukocytosis | 22.96 | 11.45 | 34 | 201851 | 22545 | 50380694 |
Injection site haemorrhage | 22.84 | 11.45 | 31 | 201854 | 21315 | 50381924 |
Hypoaesthesia oral | 22.76 | 11.45 | 94 | 201791 | 10634 | 50392605 |
Pollakiuria | 22.67 | 11.45 | 168 | 201717 | 23683 | 50379556 |
Akathisia | 22.65 | 11.45 | 3 | 201882 | 8226 | 50395013 |
Bone metabolism biochemical marker increased | 22.64 | 11.45 | 5 | 201880 | 0 | 50403239 |
Orthodontic procedure | 22.64 | 11.45 | 5 | 201880 | 0 | 50403239 |
Aphasia | 22.62 | 11.45 | 50 | 201835 | 28444 | 50374795 |
Rehabilitation therapy | 22.52 | 11.45 | 27 | 201858 | 1286 | 50401953 |
Rales | 22.46 | 11.45 | 6 | 201879 | 9972 | 50393267 |
Hip surgery | 22.40 | 11.45 | 39 | 201846 | 2619 | 50400620 |
Acute coronary syndrome | 22.34 | 11.45 | 5 | 201880 | 9369 | 50393870 |
Osteolysis | 22.18 | 11.45 | 38 | 201847 | 2519 | 50400720 |
Vaginal haemorrhage | 22.13 | 11.45 | 40 | 201845 | 24511 | 50378728 |
Shock | 22.08 | 11.45 | 30 | 201855 | 20620 | 50382619 |
Oral disorder | 21.86 | 11.45 | 75 | 201810 | 7769 | 50395470 |
Macule | 21.83 | 11.45 | 29 | 201856 | 1533 | 50401706 |
Device malfunction | 21.80 | 11.45 | 17 | 201868 | 15104 | 50388135 |
Osteocalcin decreased | 21.71 | 11.45 | 6 | 201879 | 9 | 50403230 |
Root canal infection | 21.67 | 11.45 | 13 | 201872 | 231 | 50403008 |
Angina pectoris | 21.58 | 11.45 | 45 | 201840 | 26143 | 50377096 |
Cholesteatoma | 21.56 | 11.45 | 11 | 201874 | 140 | 50403099 |
Amenorrhoea | 21.31 | 11.45 | 4 | 201881 | 8480 | 50394759 |
Gingival ulceration | 21.28 | 11.45 | 21 | 201864 | 801 | 50402438 |
Ankle fracture | 21.24 | 11.45 | 121 | 201764 | 15601 | 50387638 |
Blood glucose decreased | 20.99 | 11.45 | 25 | 201860 | 18186 | 50385053 |
Patella fracture | 20.97 | 11.45 | 31 | 201854 | 1811 | 50401428 |
Gastroenteritis | 20.93 | 11.45 | 38 | 201847 | 23243 | 50379996 |
Delusion | 20.87 | 11.45 | 8 | 201877 | 10561 | 50392678 |
Ventricular fibrillation | 20.84 | 11.45 | 8 | 201877 | 10551 | 50392688 |
Dysstasia | 20.79 | 11.45 | 132 | 201753 | 17687 | 50385552 |
Coordination abnormal | 20.75 | 11.45 | 10 | 201875 | 11524 | 50391715 |
Hyperthermia | 20.73 | 11.45 | 3 | 201882 | 7693 | 50395546 |
Adrenal insufficiency | 20.55 | 11.45 | 16 | 201869 | 14227 | 50389012 |
Cardiac failure | 20.48 | 11.45 | 199 | 201686 | 75841 | 50327398 |
Oliguria | 20.37 | 11.45 | 4 | 201881 | 8212 | 50395027 |
Generalised oedema | 20.35 | 11.45 | 15 | 201870 | 13716 | 50389523 |
Bronchopulmonary aspergillosis | 20.35 | 11.45 | 3 | 201882 | 7589 | 50395650 |
Abscess oral | 20.35 | 11.45 | 26 | 201859 | 1322 | 50401917 |
Creatinine renal clearance decreased | 20.33 | 11.45 | 11 | 201874 | 11870 | 50391369 |
Oral mucosal erythema | 20.24 | 11.45 | 26 | 201859 | 1329 | 50401910 |
Skin exfoliation | 20.14 | 11.45 | 214 | 201671 | 33398 | 50369841 |
Atelectasis | 20.09 | 11.45 | 26 | 201859 | 18244 | 50384995 |
Hepatic failure | 20.05 | 11.45 | 64 | 201821 | 32219 | 50371020 |
Carcinoembryonic antigen increased | 20.04 | 11.45 | 27 | 201858 | 1447 | 50401792 |
Gastrointestinal disorder | 20.00 | 11.45 | 261 | 201624 | 94195 | 50309044 |
Dental prosthesis user | 19.94 | 11.45 | 8 | 201877 | 55 | 50403184 |
Musculoskeletal disorder | 19.92 | 11.45 | 128 | 201757 | 17221 | 50386018 |
Gestational diabetes | 19.90 | 11.45 | 3 | 201882 | 7462 | 50395777 |
Therapy interrupted | 19.86 | 11.45 | 31 | 201854 | 20121 | 50383118 |
Kyphosis | 19.77 | 11.45 | 34 | 201851 | 2261 | 50400978 |
Acute hepatic failure | 19.74 | 11.45 | 20 | 201865 | 15657 | 50387582 |
Sleep apnoea syndrome | 19.68 | 11.45 | 41 | 201844 | 23827 | 50379412 |
Weight bearing difficulty | 19.67 | 11.45 | 34 | 201851 | 2270 | 50400969 |
Schizophrenia | 19.65 | 11.45 | 3 | 201882 | 7394 | 50395845 |
Acute myocardial infarction | 19.63 | 11.45 | 56 | 201829 | 29217 | 50374022 |
Peri-implantitis | 19.63 | 11.45 | 7 | 201878 | 33 | 50403206 |
Pain of skin | 19.59 | 11.45 | 73 | 201812 | 7874 | 50395365 |
Blood pressure systolic increased | 19.50 | 11.45 | 74 | 201811 | 35375 | 50367864 |
Lymphoedema | 19.41 | 11.45 | 80 | 201805 | 9042 | 50394197 |
Adverse event | 19.37 | 11.45 | 263 | 201622 | 43500 | 50359739 |
Hair disorder | 19.36 | 11.45 | 21 | 201864 | 896 | 50402343 |
Pleural neoplasm | 19.25 | 11.45 | 12 | 201873 | 229 | 50403010 |
Progressive multifocal leukoencephalopathy | 19.04 | 11.45 | 11 | 201874 | 11446 | 50391793 |
Lung neoplasm malignant | 18.88 | 11.45 | 116 | 201769 | 15368 | 50387871 |
Hallucination, visual | 18.86 | 11.45 | 23 | 201862 | 16559 | 50386680 |
Panic attack | 18.83 | 11.45 | 30 | 201855 | 19312 | 50383927 |
Muscle tightness | 18.70 | 11.45 | 86 | 201799 | 10194 | 50393045 |
Vertebroplasty | 18.67 | 11.45 | 13 | 201872 | 301 | 50402938 |
Triple negative breast cancer | 18.63 | 11.45 | 9 | 201876 | 101 | 50403138 |
Mastectomy | 18.60 | 11.45 | 26 | 201859 | 1443 | 50401796 |
Clavicle fracture | 18.41 | 11.45 | 38 | 201847 | 2901 | 50400338 |
Ocular hyperaemia | 18.35 | 11.45 | 33 | 201852 | 20259 | 50382980 |
Blood pressure diastolic decreased | 18.33 | 11.45 | 24 | 201861 | 16757 | 50386482 |
Oral neoplasm benign | 18.29 | 11.45 | 5 | 201880 | 7 | 50403232 |
Productive cough | 18.24 | 11.45 | 129 | 201756 | 52565 | 50350674 |
Hepatic function abnormal | 18.12 | 11.45 | 68 | 201817 | 32613 | 50370626 |
Lip and/or oral cavity cancer | 18.09 | 11.45 | 13 | 201872 | 317 | 50402922 |
Hepatic cytolysis | 18.00 | 11.45 | 5 | 201880 | 8098 | 50395141 |
Mental disorder | 17.94 | 11.45 | 38 | 201847 | 21953 | 50381286 |
Proteinuria | 17.86 | 11.45 | 24 | 201861 | 16573 | 50386666 |
Platelet count increased | 17.80 | 11.45 | 19 | 201866 | 14521 | 50388718 |
Speech disorder | 17.80 | 11.45 | 77 | 201808 | 35471 | 50367768 |
VIth nerve paresis | 17.63 | 11.45 | 8 | 201877 | 77 | 50403162 |
Hypoaesthesia | 17.62 | 11.45 | 647 | 201238 | 126610 | 50276629 |
Tricuspid valve incompetence | 17.61 | 11.45 | 15 | 201870 | 12755 | 50390484 |
Gingival injury | 17.61 | 11.45 | 6 | 201879 | 24 | 50403215 |
Aspergillus infection | 17.60 | 11.45 | 3 | 201882 | 6818 | 50396421 |
Limb discomfort | 17.48 | 11.45 | 161 | 201724 | 24196 | 50379043 |
Deformity | 17.45 | 11.45 | 5 | 201880 | 7935 | 50395304 |
Blood urea increased | 17.43 | 11.45 | 43 | 201842 | 23542 | 50379697 |
Wrong product administered | 17.41 | 11.45 | 54 | 201831 | 5306 | 50397933 |
Pallor | 17.37 | 11.45 | 42 | 201843 | 23157 | 50380082 |
CYP3A4 polymorphism | 17.36 | 11.45 | 8 | 201877 | 80 | 50403159 |
Hypovolaemia | 17.35 | 11.45 | 8 | 201877 | 9457 | 50393782 |
Anger | 17.30 | 11.45 | 12 | 201873 | 11321 | 50391918 |
Ulna fracture | 17.27 | 11.45 | 21 | 201864 | 1015 | 50402224 |
Pseudomonas infection | 17.24 | 11.45 | 8 | 201877 | 9422 | 50393817 |
Metastases to bladder | 17.11 | 11.45 | 10 | 201875 | 169 | 50403070 |
Heart rate irregular | 17.04 | 11.45 | 32 | 201853 | 19328 | 50383911 |
Catheter site injury | 17.01 | 11.45 | 9 | 201876 | 124 | 50403115 |
Epilepsy | 16.99 | 11.45 | 38 | 201847 | 21529 | 50381710 |
Lip exfoliation | 16.93 | 11.45 | 15 | 201870 | 498 | 50402741 |
Vertebral wedging | 16.87 | 11.45 | 5 | 201880 | 11 | 50403228 |
Thrombotic microangiopathy | 16.79 | 11.45 | 7 | 201878 | 8784 | 50394455 |
Ankylosing spondylitis | 16.72 | 11.45 | 4 | 201881 | 7161 | 50396078 |
Malocclusion | 16.70 | 11.45 | 8 | 201877 | 88 | 50403151 |
Metastases to adrenals | 16.62 | 11.45 | 17 | 201868 | 677 | 50402562 |
Drug level decreased | 16.58 | 11.45 | 3 | 201882 | 6530 | 50396709 |
Cerebral haemorrhage | 16.54 | 11.45 | 54 | 201831 | 26998 | 50376241 |
Haemorrhage intracranial | 16.50 | 11.45 | 15 | 201870 | 12359 | 50390880 |
Pre-existing condition improved | 16.49 | 11.45 | 4 | 201881 | 7093 | 50396146 |
Upper gastrointestinal haemorrhage | 16.45 | 11.45 | 24 | 201861 | 16011 | 50387228 |
Presyncope | 16.44 | 11.45 | 46 | 201839 | 24152 | 50379087 |
Mood altered | 16.43 | 11.45 | 16 | 201869 | 12757 | 50390482 |
Tenosynovitis | 16.37 | 11.45 | 11 | 201874 | 10554 | 50392685 |
Osteochondrosis | 16.36 | 11.45 | 21 | 201864 | 1073 | 50402166 |
Allergy to plants | 16.30 | 11.45 | 16 | 201869 | 606 | 50402633 |
Eye irritation | 16.29 | 11.45 | 27 | 201858 | 17113 | 50386126 |
Gingival discolouration | 16.28 | 11.45 | 11 | 201874 | 242 | 50402997 |
Bladder cancer | 16.27 | 11.45 | 39 | 201846 | 3293 | 50399946 |
Parathyroid tumour benign | 16.26 | 11.45 | 16 | 201869 | 608 | 50402631 |
Stress | 16.13 | 11.45 | 137 | 201748 | 53656 | 50349583 |
Activated partial thromboplastin time prolonged | 16.12 | 11.45 | 3 | 201882 | 6399 | 50396840 |
Product administration error | 16.11 | 11.45 | 34 | 201851 | 19665 | 50383574 |
Colitis | 16.09 | 11.45 | 89 | 201796 | 38440 | 50364799 |
Bone marrow oedema | 16.07 | 11.45 | 18 | 201867 | 796 | 50402443 |
Infusion site extravasation | 16.07 | 11.45 | 4 | 201881 | 6972 | 50396267 |
Dental cyst | 16.07 | 11.45 | 6 | 201879 | 33 | 50403206 |
Injection site warmth | 16.02 | 11.45 | 19 | 201866 | 13847 | 50389392 |
Vertebral lesion | 16.00 | 11.45 | 14 | 201871 | 457 | 50402782 |
Decreased immune responsiveness | 15.99 | 11.45 | 43 | 201842 | 3898 | 50399341 |
Eastern Cooperative Oncology Group performance status worsened | 15.96 | 11.45 | 16 | 201869 | 622 | 50402617 |
Drug eruption | 15.95 | 11.45 | 45 | 201840 | 23561 | 50379678 |
Skin necrosis | 15.94 | 11.45 | 12 | 201873 | 10855 | 50392384 |
Central nervous system lesion | 15.93 | 11.45 | 9 | 201876 | 9480 | 50393759 |
Breast cancer recurrent | 15.90 | 11.45 | 42 | 201843 | 3766 | 50399473 |
Dental paraesthesia | 15.89 | 11.45 | 4 | 201881 | 3 | 50403236 |
Injected limb mobility decreased | 15.89 | 11.45 | 4 | 201881 | 3 | 50403236 |
Panniculitis | 15.88 | 11.45 | 7 | 201878 | 8496 | 50394743 |
Medial tibial stress syndrome | 15.80 | 11.45 | 8 | 201877 | 100 | 50403139 |
Febrile bone marrow aplasia | 15.80 | 11.45 | 3 | 201882 | 6308 | 50396931 |
Inflammation | 15.73 | 11.45 | 148 | 201737 | 56764 | 50346475 |
Adnexa uteri mass | 15.72 | 11.45 | 14 | 201871 | 468 | 50402771 |
Subarachnoid haemorrhage | 15.68 | 11.45 | 12 | 201873 | 10764 | 50392475 |
Cancer pain | 15.68 | 11.45 | 33 | 201852 | 2554 | 50400685 |
Spinal disorder | 15.65 | 11.45 | 70 | 201815 | 8200 | 50395039 |
Facial pain | 15.62 | 11.45 | 66 | 201819 | 7543 | 50395696 |
Thyroid operation | 15.61 | 11.45 | 9 | 201876 | 148 | 50403091 |
Myocardial ischaemia | 15.58 | 11.45 | 14 | 201871 | 11599 | 50391640 |
Pulmonary fibrosis | 15.49 | 11.45 | 48 | 201837 | 24389 | 50378850 |
Chronic kidney disease | 15.47 | 11.45 | 94 | 201791 | 39677 | 50363562 |
Electrolyte imbalance | 15.45 | 11.45 | 28 | 201857 | 17141 | 50386098 |
Visual impairment | 15.45 | 11.45 | 186 | 201699 | 68089 | 50335150 |
Haemodialysis | 15.43 | 11.45 | 7 | 201878 | 8355 | 50394884 |
Psychomotor hyperactivity | 15.36 | 11.45 | 9 | 201876 | 9292 | 50393947 |
Hypercalcaemic nephropathy | 15.36 | 11.45 | 4 | 201881 | 4 | 50403235 |
Mitral valve incompetence | 15.27 | 11.45 | 29 | 201856 | 17442 | 50385797 |
Cardiomegaly | 15.27 | 11.45 | 25 | 201860 | 15920 | 50387319 |
Osteomalacia | 15.26 | 11.45 | 16 | 201869 | 656 | 50402583 |
Intervertebral disc protrusion | 15.24 | 11.45 | 136 | 201749 | 20257 | 50382982 |
Blood pressure abnormal | 15.23 | 11.45 | 95 | 201790 | 12652 | 50390587 |
Cellulitis | 15.21 | 11.45 | 380 | 201505 | 70418 | 50332821 |
Myelodysplastic syndrome | 15.18 | 11.45 | 23 | 201862 | 15109 | 50388130 |
Bone deformity | 15.16 | 11.45 | 14 | 201871 | 491 | 50402748 |
Myelosuppression | 15.11 | 11.45 | 19 | 201866 | 13498 | 50389741 |
Oral pustule | 15.11 | 11.45 | 6 | 201879 | 40 | 50403199 |
Rectal haemorrhage | 15.06 | 11.45 | 91 | 201794 | 38467 | 50364772 |
Liver function test increased | 15.05 | 11.45 | 52 | 201833 | 25554 | 50377685 |
Clostridium difficile colitis | 15.03 | 11.45 | 30 | 201855 | 17712 | 50385527 |
Cholecystitis | 14.99 | 11.45 | 20 | 201865 | 13851 | 50389388 |
Hypoaesthesia teeth | 14.86 | 11.45 | 6 | 201879 | 42 | 50403197 |
Arthritis | 14.83 | 11.45 | 452 | 201433 | 86269 | 50316970 |
Conjunctivitis | 14.83 | 11.45 | 26 | 201859 | 16119 | 50387120 |
Demyelination | 14.80 | 11.45 | 3 | 201882 | 6023 | 50397216 |
Brachiocephalic vein thrombosis | 14.77 | 11.45 | 7 | 201878 | 75 | 50403164 |
Dyspnoea exertional | 14.69 | 11.45 | 132 | 201753 | 51101 | 50352138 |
Subdural haematoma | 14.68 | 11.45 | 18 | 201867 | 12929 | 50390310 |
Granuloma annulare | 14.65 | 11.45 | 14 | 201871 | 513 | 50402726 |
Fracture pain | 14.62 | 11.45 | 12 | 201873 | 358 | 50402881 |
Malabsorption | 14.60 | 11.45 | 40 | 201845 | 3666 | 50399573 |
Hepatic lesion | 14.55 | 11.45 | 42 | 201843 | 3966 | 50399273 |
Pulmonary congestion | 14.51 | 11.45 | 24 | 201861 | 15223 | 50388016 |
Degenerative bone disease | 14.51 | 11.45 | 6 | 201879 | 45 | 50403194 |
Crying | 14.48 | 11.45 | 38 | 201847 | 20378 | 50382861 |
Rash erythematous | 14.43 | 11.45 | 207 | 201678 | 34645 | 50368594 |
Giant cell arteritis | 14.43 | 11.45 | 26 | 201859 | 1794 | 50401445 |
Cardiotoxicity | 14.42 | 11.45 | 5 | 201880 | 7022 | 50396217 |
Inguinal hernia repair | 14.40 | 11.45 | 6 | 201879 | 46 | 50403193 |
Pulmonary tumour thrombotic microangiopathy | 14.29 | 11.45 | 6 | 201879 | 47 | 50403192 |
Muscle rigidity | 14.23 | 11.45 | 11 | 201874 | 9818 | 50393421 |
Skin haemorrhage | 14.20 | 11.45 | 60 | 201825 | 6858 | 50396381 |
Pleural disorder | 14.18 | 11.45 | 14 | 201871 | 534 | 50402705 |
Diverticulitis | 14.11 | 11.45 | 198 | 201687 | 32984 | 50370255 |
Transaminases increased | 14.10 | 11.45 | 60 | 201825 | 27764 | 50375475 |
Gastroenteritis viral | 14.08 | 11.45 | 34 | 201851 | 18752 | 50384487 |
Acetabulum fracture | 14.05 | 11.45 | 10 | 201875 | 240 | 50402999 |
Bone sequestrum | 14.01 | 11.45 | 22 | 201863 | 1356 | 50401883 |
Parkinsonism | 14.00 | 11.45 | 9 | 201876 | 8838 | 50394401 |
Skin disorder | 13.94 | 11.45 | 152 | 201733 | 23878 | 50379361 |
Encephalitis | 13.90 | 11.45 | 6 | 201879 | 7374 | 50395865 |
Sternal fracture | 13.88 | 11.45 | 27 | 201858 | 1975 | 50401264 |
Rash maculo-papular | 13.78 | 11.45 | 57 | 201828 | 26584 | 50376655 |
General physical health deterioration | 13.76 | 11.45 | 448 | 201437 | 141986 | 50261253 |
Small intestinal obstruction | 13.76 | 11.45 | 27 | 201858 | 16041 | 50387198 |
Ventricular extrasystoles | 13.72 | 11.45 | 13 | 201872 | 10503 | 50392736 |
Hepatic encephalopathy | 13.68 | 11.45 | 11 | 201874 | 9625 | 50393614 |
Breath sounds abnormal | 13.65 | 11.45 | 7 | 201878 | 7785 | 50395454 |
Platelet count decreased | 13.61 | 11.45 | 302 | 201583 | 100424 | 50302815 |
Osteosarcoma recurrent | 13.58 | 11.45 | 3 | 201882 | 0 | 50403239 |
Blood 1,25-dihydroxycholecalciferol increased | 13.58 | 11.45 | 3 | 201882 | 0 | 50403239 |
Serum procollagen type I N-terminal propeptide decreased | 13.58 | 11.45 | 3 | 201882 | 0 | 50403239 |
Bone giant cell tumour malignant | 13.58 | 11.45 | 3 | 201882 | 0 | 50403239 |
Thyroid calcification | 13.58 | 11.45 | 3 | 201882 | 0 | 50403239 |
C-telopeptide | 13.58 | 11.45 | 3 | 201882 | 0 | 50403239 |
Masticatory pain | 13.58 | 11.45 | 3 | 201882 | 0 | 50403239 |
Urine abnormality | 13.58 | 11.45 | 4 | 201881 | 6234 | 50397005 |
Urinary retention | 13.56 | 11.45 | 56 | 201829 | 26134 | 50377105 |
Tachyphylaxis | 13.56 | 11.45 | 10 | 201875 | 254 | 50402985 |
Diffuse large B-cell lymphoma | 13.53 | 11.45 | 3 | 201882 | 5659 | 50397580 |
Oligodipsia | 13.47 | 11.45 | 5 | 201880 | 27 | 50403212 |
Urethritis noninfective | 13.43 | 11.45 | 4 | 201881 | 9 | 50403230 |
Mucosal pain | 13.43 | 11.45 | 4 | 201881 | 9 | 50403230 |
Chronic leukaemia | 13.43 | 11.45 | 4 | 201881 | 9 | 50403230 |
Eye pain | 13.42 | 11.45 | 63 | 201822 | 28386 | 50374853 |
Jaundice | 13.38 | 11.45 | 57 | 201828 | 26372 | 50376867 |
Fibula fracture | 13.38 | 11.45 | 34 | 201851 | 2978 | 50400261 |
Angina unstable | 13.37 | 11.45 | 5 | 201880 | 6701 | 50396538 |
Haemophagocytic lymphohistiocytosis | 13.36 | 11.45 | 9 | 201876 | 8624 | 50394615 |
Ovarian cyst | 13.35 | 11.45 | 22 | 201863 | 13974 | 50389265 |
Tooth discolouration | 13.34 | 11.45 | 17 | 201868 | 862 | 50402377 |
Hypotonia | 13.25 | 11.45 | 8 | 201877 | 8126 | 50395113 |
Hypercalcaemia of malignancy | 13.24 | 11.45 | 8 | 201877 | 144 | 50403095 |
Osteosclerosis | 13.24 | 11.45 | 37 | 201848 | 3430 | 50399809 |
Carcinoid tumour pulmonary | 13.23 | 11.45 | 12 | 201873 | 411 | 50402828 |
Periprosthetic fracture | 13.20 | 11.45 | 12 | 201873 | 412 | 50402827 |
Hepatitis cholestatic | 13.17 | 11.45 | 4 | 201881 | 6113 | 50397126 |
Dermatitis allergic | 13.08 | 11.45 | 19 | 201866 | 12701 | 50390538 |
Onychalgia | 13.07 | 11.45 | 16 | 201869 | 779 | 50402460 |
Colitis ulcerative | 13.03 | 11.45 | 30 | 201855 | 16824 | 50386415 |
Toxic encephalopathy | 13.03 | 11.45 | 3 | 201882 | 5512 | 50397727 |
Acute generalised exanthematous pustulosis | 12.95 | 11.45 | 10 | 201875 | 8928 | 50394311 |
Apathy | 12.90 | 11.45 | 7 | 201878 | 7541 | 50395698 |
Bone scan abnormal | 12.89 | 11.45 | 11 | 201874 | 347 | 50402892 |
Fear | 12.85 | 11.45 | 24 | 201861 | 14525 | 50388714 |
Injection site urticaria | 12.81 | 11.45 | 18 | 201867 | 12199 | 50391040 |
Gallbladder disorder | 12.78 | 11.45 | 30 | 201855 | 16712 | 50386527 |
Enteritis | 12.69 | 11.45 | 6 | 201879 | 6989 | 50396250 |
Blood cholesterol abnormal | 12.68 | 11.45 | 28 | 201857 | 2240 | 50400999 |
Pulmonary haemorrhage | 12.68 | 11.45 | 5 | 201880 | 6487 | 50396752 |
Injection site induration | 12.67 | 11.45 | 9 | 201876 | 8388 | 50394851 |
Mood swings | 12.66 | 11.45 | 28 | 201857 | 15926 | 50387313 |
Eosinophil count increased | 12.64 | 11.45 | 10 | 201875 | 8820 | 50394419 |
Aspiration | 12.63 | 11.45 | 11 | 201874 | 9253 | 50393986 |
Carbohydrate antigen 19-9 increased | 12.55 | 11.45 | 8 | 201877 | 159 | 50403080 |
Bone fistula | 12.52 | 11.45 | 6 | 201879 | 66 | 50403173 |
Quality of life decreased | 12.51 | 11.45 | 54 | 201831 | 6229 | 50397010 |
Sinus congestion | 12.38 | 11.45 | 23 | 201862 | 13948 | 50389291 |
Varicophlebitis | 12.38 | 11.45 | 4 | 201881 | 13 | 50403226 |
Infusion site erythema | 12.34 | 11.45 | 10 | 201875 | 8717 | 50394522 |
Urine output decreased | 12.34 | 11.45 | 14 | 201871 | 10407 | 50392832 |
Hypercalciuria | 12.33 | 11.45 | 9 | 201876 | 225 | 50403014 |
Hot flush | 12.30 | 11.45 | 246 | 201639 | 43923 | 50359316 |
Thinking abnormal | 12.28 | 11.45 | 12 | 201873 | 9555 | 50393684 |
Cardiac murmur | 12.22 | 11.45 | 15 | 201870 | 10769 | 50392470 |
Metastases to neck | 12.21 | 11.45 | 6 | 201879 | 70 | 50403169 |
Pneumonia viral | 12.18 | 11.45 | 6 | 201879 | 6828 | 50396411 |
Face oedema | 12.06 | 11.45 | 34 | 201851 | 17805 | 50385434 |
Device difficult to use | 12.01 | 11.45 | 13 | 201872 | 9873 | 50393366 |
Fibromyalgia | 11.99 | 11.45 | 118 | 201767 | 44860 | 50358379 |
Skin sensitisation | 11.97 | 11.45 | 15 | 201870 | 748 | 50402491 |
Bipolar disorder | 11.94 | 11.45 | 6 | 201879 | 6751 | 50396488 |
Blood pressure systolic decreased | 11.92 | 11.45 | 4 | 201881 | 5735 | 50397504 |
Nail growth abnormal | 11.92 | 11.45 | 12 | 201873 | 469 | 50402770 |
Jaw cyst | 11.89 | 11.45 | 7 | 201878 | 120 | 50403119 |
Rhinorrhoea | 11.87 | 11.45 | 140 | 201745 | 51443 | 50351796 |
Troponin increased | 11.86 | 11.45 | 9 | 201876 | 8109 | 50395130 |
Lipase increased | 11.82 | 11.45 | 10 | 201875 | 8531 | 50394708 |
Ear disorder | 11.79 | 11.45 | 34 | 201851 | 3209 | 50400030 |
Multiple sclerosis | 11.79 | 11.45 | 42 | 201843 | 20451 | 50382788 |
Abnormal dreams | 11.77 | 11.45 | 12 | 201873 | 9365 | 50393874 |
Pathogen resistance | 11.75 | 11.45 | 4 | 201881 | 5685 | 50397554 |
Callus formation delayed | 11.74 | 11.45 | 4 | 201881 | 16 | 50403223 |
Transfusion | 11.65 | 11.45 | 21 | 201864 | 12884 | 50390355 |
Vascular fragility | 11.64 | 11.45 | 7 | 201878 | 125 | 50403114 |
Papule | 11.63 | 11.45 | 41 | 201844 | 4304 | 50398935 |
Motor dysfunction | 11.61 | 11.45 | 9 | 201876 | 8022 | 50395217 |
Nephropathy toxic | 11.61 | 11.45 | 9 | 201876 | 8020 | 50395219 |
Hepatic cancer | 11.58 | 11.45 | 34 | 201851 | 3241 | 50399998 |
Blood potassium decreased | 11.57 | 11.45 | 93 | 201792 | 36852 | 50366387 |
Metastases to vagina | 11.55 | 11.45 | 4 | 201881 | 17 | 50403222 |
Extradural neoplasm | 11.52 | 11.45 | 3 | 201882 | 3 | 50403236 |
Parathyroid hormone-related protein increased | 11.52 | 11.45 | 3 | 201882 | 3 | 50403236 |
Tartrate-resistant acid phosphatase increased | 11.52 | 11.45 | 3 | 201882 | 3 | 50403236 |
Bone erosion | 11.50 | 11.45 | 18 | 201867 | 11669 | 50391570 |
Tuberculosis | 11.45 | 11.45 | 14 | 201871 | 10069 | 50393170 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Osteonecrosis of jaw | 7496.78 | 13.80 | 2083 | 36879 | 14427 | 29521138 |
Off label use | 4104.42 | 13.80 | 3255 | 35707 | 297545 | 29238020 |
Death | 1849.69 | 13.80 | 2243 | 36719 | 339841 | 29195724 |
Hypocalcaemia | 1770.94 | 13.80 | 750 | 38212 | 19915 | 29515650 |
Terminal state | 585.97 | 13.80 | 207 | 38755 | 3287 | 29532278 |
Prostatic specific antigen increased | 350.78 | 13.80 | 214 | 38748 | 12350 | 29523215 |
Tooth disorder | 309.58 | 13.80 | 179 | 38783 | 9350 | 29526215 |
Metastases to bone | 308.52 | 13.80 | 181 | 38781 | 9717 | 29525848 |
Tooth extraction | 294.61 | 13.80 | 132 | 38830 | 3997 | 29531568 |
Investigation | 248.71 | 13.80 | 77 | 38885 | 787 | 29534778 |
Pain in jaw | 226.12 | 13.80 | 158 | 38804 | 11483 | 29524082 |
Hospitalisation | 225.35 | 13.80 | 290 | 38672 | 45698 | 29489867 |
Bone pain | 223.28 | 13.80 | 189 | 38773 | 18263 | 29517302 |
Malignant neoplasm progression | 215.78 | 13.80 | 365 | 38597 | 73494 | 29462071 |
Atypical femur fracture | 203.74 | 13.80 | 52 | 38910 | 239 | 29535326 |
Prostate cancer metastatic | 179.34 | 13.80 | 100 | 38862 | 4866 | 29530699 |
Exposed bone in jaw | 175.26 | 13.80 | 68 | 38894 | 1418 | 29534147 |
Blood calcium decreased | 172.21 | 13.80 | 122 | 38840 | 9060 | 29526505 |
Hypophosphataemia | 166.72 | 13.80 | 113 | 38849 | 7811 | 29527754 |
Blood parathyroid hormone increased | 156.25 | 13.80 | 61 | 38901 | 1294 | 29534271 |
Toxicity to various agents | 142.49 | 13.80 | 28 | 38934 | 173633 | 29361932 |
Jaw disorder | 139.36 | 13.80 | 63 | 38899 | 1947 | 29533618 |
Osteomyelitis | 129.26 | 13.80 | 122 | 38840 | 13587 | 29521978 |
Prostate cancer | 117.20 | 13.80 | 156 | 38806 | 25371 | 29510194 |
Osteitis | 114.55 | 13.80 | 50 | 38912 | 1419 | 29534146 |
Drug ineffective | 114.06 | 13.80 | 190 | 38772 | 362980 | 29172585 |
Hypercalcaemia | 107.96 | 13.80 | 107 | 38855 | 12652 | 29522913 |
Completed suicide | 101.49 | 13.80 | 4 | 38958 | 90242 | 29445323 |
Toothache | 101.38 | 13.80 | 73 | 38889 | 5559 | 29530006 |
Drug interaction | 93.48 | 13.80 | 74 | 38888 | 197311 | 29338254 |
Bone density abnormal | 84.63 | 13.80 | 19 | 38943 | 43 | 29535522 |
Occupational exposure to product | 82.33 | 13.80 | 26 | 38936 | 285 | 29535280 |
Hot flush | 79.44 | 13.80 | 98 | 38864 | 14772 | 29520793 |
Back pain | 76.83 | 13.80 | 302 | 38660 | 101982 | 29433583 |
Dental care | 74.66 | 13.80 | 22 | 38940 | 187 | 29535378 |
Condition aggravated | 71.56 | 13.80 | 53 | 38909 | 146242 | 29389323 |
Hypotension | 71.26 | 13.80 | 91 | 38871 | 194263 | 29341302 |
Abscess jaw | 69.21 | 13.80 | 28 | 38934 | 654 | 29534911 |
Hormone-refractory prostate cancer | 67.90 | 13.80 | 27 | 38935 | 602 | 29534963 |
Spinal fracture | 67.48 | 13.80 | 61 | 38901 | 6425 | 29529140 |
Acute kidney injury | 62.60 | 13.80 | 163 | 38799 | 265104 | 29270461 |
Tooth fracture | 61.64 | 13.80 | 43 | 38919 | 3113 | 29532452 |
Metastases to lung | 61.18 | 13.80 | 63 | 38899 | 7792 | 29527773 |
Incorrect route of product administration | 60.64 | 13.80 | 73 | 38889 | 10728 | 29524837 |
Cardiac arrest | 58.28 | 13.80 | 20 | 38942 | 85571 | 29449994 |
Osteonecrosis | 58.04 | 13.80 | 80 | 38882 | 13439 | 29522126 |
Dental implantation | 57.23 | 13.80 | 14 | 38948 | 52 | 29535513 |
Femur fracture | 56.14 | 13.80 | 57 | 38905 | 6934 | 29528631 |
Pathological fracture | 53.95 | 13.80 | 43 | 38919 | 3812 | 29531753 |
Blood calcium abnormal | 53.89 | 13.80 | 21 | 38941 | 443 | 29535122 |
Overdose | 53.74 | 13.80 | 19 | 38943 | 79800 | 29455765 |
Jaw operation | 53.69 | 13.80 | 17 | 38945 | 188 | 29535377 |
Accidental exposure to product | 52.87 | 13.80 | 68 | 38894 | 10685 | 29524880 |
Tetany | 49.89 | 13.80 | 22 | 38940 | 640 | 29534925 |
Metastasis | 49.60 | 13.80 | 39 | 38923 | 3390 | 29532175 |
Dental caries | 46.83 | 13.80 | 41 | 38921 | 4139 | 29531426 |
Metastases to lymph nodes | 46.21 | 13.80 | 40 | 38922 | 3977 | 29531588 |
Tooth loss | 45.16 | 13.80 | 38 | 38924 | 3636 | 29531929 |
Bone fissure | 45.05 | 13.80 | 10 | 38952 | 21 | 29535544 |
Fracture | 44.37 | 13.80 | 47 | 38915 | 6006 | 29529559 |
Tooth abscess | 44.17 | 13.80 | 43 | 38919 | 4971 | 29530594 |
Impaired healing | 43.51 | 13.80 | 70 | 38892 | 13488 | 29522077 |
Thoracic vertebral fracture | 42.05 | 13.80 | 25 | 38937 | 1373 | 29534192 |
Fatigue | 41.67 | 13.80 | 616 | 38346 | 316205 | 29219360 |
Endodontic procedure | 40.82 | 13.80 | 16 | 38946 | 343 | 29535222 |
Agitation | 40.49 | 13.80 | 9 | 38953 | 51295 | 29484270 |
Bradycardia | 40.27 | 13.80 | 18 | 38944 | 65611 | 29469954 |
Gastrointestinal haemorrhage | 39.90 | 13.80 | 28 | 38934 | 79505 | 29456060 |
Blood phosphorus decreased | 38.84 | 13.80 | 31 | 38931 | 2754 | 29532811 |
Exostosis of jaw | 38.25 | 13.80 | 11 | 38951 | 85 | 29535480 |
Bone density decreased | 37.83 | 13.80 | 25 | 38937 | 1655 | 29533910 |
Loose tooth | 36.80 | 13.80 | 21 | 38941 | 1068 | 29534497 |
Cardio-respiratory arrest | 35.88 | 13.80 | 11 | 38951 | 50590 | 29484975 |
Artificial crown procedure | 35.66 | 13.80 | 8 | 38954 | 18 | 29535547 |
Decreased appetite | 35.51 | 13.80 | 319 | 38643 | 145023 | 29390542 |
Jaw fistula | 35.50 | 13.80 | 9 | 38953 | 40 | 29535525 |
Metastases to central nervous system | 34.91 | 13.80 | 45 | 38917 | 7086 | 29528479 |
Hip fracture | 34.80 | 13.80 | 55 | 38907 | 10437 | 29525128 |
Cancer pain | 34.61 | 13.80 | 27 | 38935 | 2320 | 29533245 |
Tachycardia | 34.38 | 13.80 | 27 | 38935 | 72383 | 29463182 |
Drug hypersensitivity | 33.12 | 13.80 | 25 | 38937 | 68381 | 29467184 |
Respiratory failure | 32.98 | 13.80 | 48 | 38914 | 97083 | 29438482 |
Prostate cancer recurrent | 31.87 | 13.80 | 18 | 38944 | 897 | 29534668 |
Chest pain | 31.87 | 13.80 | 62 | 38900 | 111911 | 29423654 |
Stress fracture | 31.57 | 13.80 | 17 | 38945 | 771 | 29534794 |
Hospice care | 31.34 | 13.80 | 36 | 38926 | 5032 | 29530533 |
Coma | 30.97 | 13.80 | 7 | 38955 | 39443 | 29496122 |
Spinal pain | 30.84 | 13.80 | 35 | 38927 | 4829 | 29530736 |
International normalised ratio increased | 30.83 | 13.80 | 10 | 38952 | 44362 | 29491203 |
Gingival disorder | 30.79 | 13.80 | 20 | 38942 | 1286 | 29534279 |
Seizure | 30.66 | 13.80 | 47 | 38915 | 93076 | 29442489 |
Palliative care | 30.51 | 13.80 | 14 | 38948 | 448 | 29535117 |
Failure to anastomose | 29.54 | 13.80 | 11 | 38951 | 204 | 29535361 |
Blood calcium increased | 29.10 | 13.80 | 28 | 38934 | 3191 | 29532374 |
Sequestrectomy | 28.82 | 13.80 | 11 | 38951 | 219 | 29535346 |
Dental fistula | 28.39 | 13.80 | 9 | 38953 | 100 | 29535465 |
Metastases to soft tissue | 28.36 | 13.80 | 11 | 38951 | 229 | 29535336 |
Metastases to spine | 27.77 | 13.80 | 23 | 38939 | 2153 | 29533412 |
Suicidal ideation | 27.57 | 13.80 | 6 | 38956 | 34710 | 29500855 |
Atypical fracture | 27.03 | 13.80 | 9 | 38953 | 118 | 29535447 |
Periodontitis | 27.00 | 13.80 | 21 | 38941 | 1796 | 29533769 |
Carbohydrate antigen 15-3 increased | 26.94 | 13.80 | 8 | 38954 | 70 | 29535495 |
Hyperparathyroidism | 25.80 | 13.80 | 17 | 38945 | 1120 | 29534445 |
Febrile neutropenia | 25.60 | 13.80 | 70 | 38892 | 112170 | 29423395 |
Gingivitis | 25.48 | 13.80 | 25 | 38937 | 2917 | 29532648 |
Lumbar vertebral fracture | 25.14 | 13.80 | 20 | 38942 | 1768 | 29533797 |
Metastases to liver | 24.99 | 13.80 | 51 | 38911 | 11805 | 29523760 |
Neoplasm progression | 24.89 | 13.80 | 67 | 38895 | 18545 | 29517020 |
Arthralgia | 24.76 | 13.80 | 287 | 38675 | 139330 | 29396235 |
Aggression | 24.71 | 13.80 | 8 | 38954 | 35533 | 29500032 |
Bone disorder | 24.48 | 13.80 | 34 | 38928 | 5749 | 29529816 |
Blood glucose increased | 24.39 | 13.80 | 25 | 38937 | 58959 | 29476606 |
Disease progression | 24.35 | 13.80 | 188 | 38774 | 81728 | 29453837 |
Hypoglycaemia | 24.27 | 13.80 | 17 | 38945 | 48329 | 29487236 |
Myocardial infarction | 24.26 | 13.80 | 70 | 38892 | 110226 | 29425339 |
Septic shock | 24.23 | 13.80 | 28 | 38934 | 62532 | 29473033 |
Tooth infection | 24.10 | 13.80 | 33 | 38929 | 5506 | 29530059 |
Gingival swelling | 23.40 | 13.80 | 16 | 38946 | 1121 | 29534444 |
Inappropriate schedule of product administration | 23.25 | 13.80 | 118 | 38844 | 44354 | 29491211 |
Mastication disorder | 23.11 | 13.80 | 16 | 38946 | 1144 | 29534421 |
Bone loss | 22.77 | 13.80 | 12 | 38950 | 521 | 29535044 |
Confusional state | 22.76 | 13.80 | 89 | 38873 | 127788 | 29407777 |
Multiple organ dysfunction syndrome | 22.60 | 13.80 | 30 | 38932 | 63086 | 29472479 |
Bone giant cell tumour malignant | 22.53 | 13.80 | 4 | 38958 | 0 | 29535565 |
Osteonecrosis of external auditory canal | 22.53 | 13.80 | 4 | 38958 | 0 | 29535565 |
Peri-implantitis | 22.53 | 13.80 | 4 | 38958 | 0 | 29535565 |
Lactic acidosis | 22.50 | 13.80 | 6 | 38956 | 30241 | 29505324 |
Pseudarthrosis | 22.48 | 13.80 | 7 | 38955 | 73 | 29535492 |
Nephrocalcinosis | 22.39 | 13.80 | 12 | 38950 | 539 | 29535026 |
Abdominal pain | 21.74 | 13.80 | 98 | 38864 | 135259 | 29400306 |
Alanine aminotransferase increased | 21.30 | 13.80 | 38 | 38924 | 70906 | 29464659 |
Parathyroid tumour malignant | 21.26 | 13.80 | 5 | 38957 | 15 | 29535550 |
Suture rupture | 21.20 | 13.80 | 10 | 38952 | 341 | 29535224 |
Respiratory distress | 20.99 | 13.80 | 8 | 38954 | 32098 | 29503467 |
Macroenzyme creatine kinase | 20.78 | 13.80 | 5 | 38957 | 17 | 29535548 |
Prostatic specific antigen decreased | 20.67 | 13.80 | 7 | 38955 | 97 | 29535468 |
Limbic encephalitis | 20.65 | 13.80 | 10 | 38952 | 362 | 29535203 |
Gingival abscess | 20.61 | 13.80 | 8 | 38954 | 167 | 29535398 |
Coronary artery disease | 20.31 | 13.80 | 17 | 38945 | 44173 | 29491392 |
Bone formation increased | 20.30 | 13.80 | 4 | 38958 | 3 | 29535562 |
Spinal compression fracture | 20.28 | 13.80 | 32 | 38930 | 6062 | 29529503 |
Bone lesion | 19.82 | 13.80 | 21 | 38941 | 2683 | 29532882 |
Blood bilirubin increased | 19.70 | 13.80 | 10 | 38952 | 33883 | 29501682 |
Weight increased | 19.66 | 13.80 | 45 | 38917 | 76622 | 29458943 |
Dental restoration failure | 19.58 | 13.80 | 5 | 38957 | 23 | 29535542 |
Psoriasis | 19.51 | 13.80 | 9 | 38953 | 32218 | 29503347 |
Depression | 19.48 | 13.80 | 53 | 38909 | 85094 | 29450471 |
Respiratory arrest | 19.45 | 13.80 | 5 | 38957 | 25828 | 29509737 |
Metabolic acidosis | 19.22 | 13.80 | 13 | 38949 | 37649 | 29497916 |
Product use in unapproved indication | 19.19 | 13.80 | 55 | 38907 | 86820 | 29448745 |
Abscess oral | 19.19 | 13.80 | 9 | 38953 | 303 | 29535262 |
Cough | 19.03 | 13.80 | 94 | 38868 | 126633 | 29408932 |
Tremor | 18.99 | 13.80 | 43 | 38919 | 73495 | 29462070 |
Extraskeletal ossification | 18.77 | 13.80 | 5 | 38957 | 28 | 29535537 |
Hungry bone syndrome | 18.66 | 13.80 | 6 | 38956 | 70 | 29535495 |
Shock | 18.48 | 13.80 | 3 | 38959 | 21401 | 29514164 |
Blood urea increased | 18.39 | 13.80 | 7 | 38955 | 28105 | 29507460 |
Abnormal behaviour | 18.36 | 13.80 | 4 | 38958 | 23123 | 29512442 |
Dysgeusia | 17.83 | 13.80 | 68 | 38894 | 22606 | 29512959 |
Pain | 17.47 | 13.80 | 320 | 38642 | 171112 | 29364453 |
Eosinophilia | 17.25 | 13.80 | 4 | 38958 | 22157 | 29513408 |
Calcium ionised abnormal | 16.90 | 13.80 | 3 | 38959 | 0 | 29535565 |
Product use issue | 16.89 | 13.80 | 26 | 38936 | 51418 | 29484147 |
Gingival pain | 16.81 | 13.80 | 17 | 38945 | 2057 | 29533508 |
Vipoma | 16.76 | 13.80 | 4 | 38958 | 13 | 29535552 |
Postrenal failure | 16.56 | 13.80 | 9 | 38953 | 416 | 29535149 |
Jaw fracture | 16.53 | 13.80 | 12 | 38950 | 925 | 29534640 |
Living in residential institution | 16.51 | 13.80 | 8 | 38954 | 290 | 29535275 |
Oxygen saturation decreased | 16.46 | 13.80 | 21 | 38941 | 44916 | 29490649 |
Bedridden | 16.33 | 13.80 | 21 | 38941 | 3297 | 29532268 |
Haematemesis | 16.33 | 13.80 | 6 | 38956 | 24620 | 29510945 |
Angioedema | 16.31 | 13.80 | 11 | 38951 | 31904 | 29503661 |
Wheezing | 16.27 | 13.80 | 12 | 38950 | 33228 | 29502337 |
Pyrexia | 16.23 | 13.80 | 274 | 38688 | 287348 | 29248217 |
Acute respiratory distress syndrome | 16.23 | 13.80 | 5 | 38957 | 22930 | 29512635 |
Headache | 16.13 | 13.80 | 149 | 38813 | 173858 | 29361707 |
Blood creatine phosphokinase increased | 15.94 | 13.80 | 18 | 38944 | 40626 | 29494939 |
Blood pressure decreased | 15.89 | 13.80 | 22 | 38940 | 45455 | 29490110 |
Hyperaesthesia | 15.60 | 13.80 | 21 | 38941 | 3448 | 29532117 |
Asthma | 15.58 | 13.80 | 13 | 38949 | 33836 | 29501729 |
Cystitis | 15.53 | 13.80 | 34 | 38928 | 8258 | 29527307 |
Anxiety | 15.44 | 13.80 | 59 | 38903 | 85306 | 29450259 |
Vitamin D increased | 15.35 | 13.80 | 5 | 38957 | 61 | 29535504 |
Hallucination | 15.26 | 13.80 | 22 | 38940 | 44690 | 29490875 |
Neoplasm malignant | 15.20 | 13.80 | 53 | 38909 | 16872 | 29518693 |
Paraesthesia | 15.12 | 13.80 | 122 | 38840 | 53723 | 29481842 |
Dental operation | 14.87 | 13.80 | 8 | 38954 | 362 | 29535203 |
Cytomegalovirus infection | 14.82 | 13.80 | 6 | 38956 | 23209 | 29512356 |
Bone fistula | 14.64 | 13.80 | 4 | 38958 | 25 | 29535540 |
Lung cyst | 14.64 | 13.80 | 4 | 38958 | 25 | 29535540 |
Tibia fracture | 14.64 | 13.80 | 13 | 38949 | 1337 | 29534228 |
Pulpitis dental | 14.57 | 13.80 | 8 | 38954 | 377 | 29535188 |
Oral cavity fistula | 14.56 | 13.80 | 6 | 38956 | 147 | 29535418 |
Noninfective gingivitis | 14.46 | 13.80 | 7 | 38955 | 253 | 29535312 |
Hypersensitivity | 14.43 | 13.80 | 30 | 38932 | 52873 | 29482692 |
Chest discomfort | 14.38 | 13.80 | 24 | 38938 | 45959 | 29489606 |
Traumatic fracture | 14.36 | 13.80 | 7 | 38955 | 257 | 29535308 |
Poor peripheral circulation | 14.28 | 13.80 | 13 | 38949 | 1381 | 29534184 |
Bone giant cell tumour | 14.25 | 13.80 | 4 | 38958 | 28 | 29535537 |
Sepsis | 14.18 | 13.80 | 120 | 38842 | 142562 | 29393003 |
Acetabulum fracture | 14.12 | 13.80 | 7 | 38955 | 267 | 29535298 |
Cardiogenic shock | 13.91 | 13.80 | 4 | 38958 | 19186 | 29516379 |
Sedation | 13.83 | 13.80 | 3 | 38959 | 17402 | 29518163 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Off label use | 29352.89 | 11.44 | 19852 | 175284 | 612954 | 63690642 |
Osteonecrosis of jaw | 13019.75 | 11.44 | 4788 | 190348 | 35037 | 64268559 |
Death | 5981.53 | 11.44 | 7291 | 187845 | 475414 | 63828182 |
Hypocalcaemia | 2248.96 | 11.44 | 1462 | 193674 | 40291 | 64263305 |
Bone pain | 1726.11 | 11.44 | 1308 | 193828 | 46264 | 64257332 |
Tooth disorder | 1689.13 | 11.44 | 973 | 194163 | 21429 | 64282167 |
Spinal fracture | 1392.26 | 11.44 | 750 | 194386 | 14424 | 64289172 |
Pain in jaw | 1318.08 | 11.44 | 1047 | 194089 | 39708 | 64263888 |
Tooth extraction | 1267.95 | 11.44 | 607 | 194529 | 8994 | 64294602 |
Atypical femur fracture | 1241.81 | 11.44 | 485 | 194651 | 4213 | 64299383 |
Back pain | 1226.65 | 11.44 | 2479 | 192657 | 247692 | 64055904 |
Pain in extremity | 1064.64 | 11.44 | 2629 | 192507 | 300456 | 64003140 |
Drug ineffective | 872.68 | 11.44 | 760 | 194376 | 839487 | 63464109 |
Arthralgia | 858.36 | 11.44 | 3109 | 192027 | 439151 | 63864445 |
Bone density abnormal | 820.66 | 11.44 | 310 | 194826 | 2435 | 64301161 |
Toxicity to various agents | 787.13 | 11.44 | 90 | 195046 | 363423 | 63940173 |
Tooth fracture | 705.19 | 11.44 | 415 | 194721 | 9512 | 64294084 |
Thoracic vertebral fracture | 684.87 | 11.44 | 315 | 194821 | 4238 | 64299358 |
Myalgia | 684.08 | 11.44 | 1493 | 193643 | 157124 | 64146472 |
Completed suicide | 645.74 | 11.44 | 6 | 195130 | 224408 | 64079188 |
Metastases to bone | 645.46 | 11.44 | 518 | 194618 | 19917 | 64283679 |
Toothache | 637.01 | 11.44 | 482 | 194654 | 16977 | 64286619 |
Terminal state | 632.81 | 11.44 | 296 | 194840 | 4148 | 64299448 |
Exposed bone in jaw | 603.21 | 11.44 | 266 | 194870 | 3221 | 64300375 |
Lumbar vertebral fracture | 601.76 | 11.44 | 306 | 194830 | 5196 | 64298400 |
Rebound effect | 586.41 | 11.44 | 290 | 194846 | 4627 | 64298969 |
Drug interaction | 580.00 | 11.44 | 187 | 194949 | 361896 | 63941700 |
Bone density decreased | 578.60 | 11.44 | 366 | 194770 | 9586 | 64294010 |
Jaw disorder | 499.76 | 11.44 | 255 | 194881 | 4362 | 64299234 |
Hospitalisation | 481.70 | 11.44 | 837 | 194299 | 74370 | 64229226 |
Acute kidney injury | 462.51 | 11.44 | 408 | 194728 | 448832 | 63854764 |
Femur fracture | 447.12 | 11.44 | 534 | 194602 | 33601 | 64269995 |
Spinal compression fracture | 423.48 | 11.44 | 354 | 194782 | 14421 | 64289175 |
Investigation | 419.50 | 11.44 | 181 | 194955 | 2071 | 64301525 |
Blood parathyroid hormone increased | 419.37 | 11.44 | 200 | 194936 | 2934 | 64300662 |
Dental implantation | 406.77 | 11.44 | 116 | 195020 | 312 | 64303284 |
Groin pain | 399.01 | 11.44 | 307 | 194829 | 11086 | 64292510 |
Tooth loss | 396.63 | 11.44 | 243 | 194893 | 6004 | 64297592 |
Drug abuse | 383.21 | 11.44 | 3 | 195133 | 132371 | 64171225 |
Osteomyelitis | 376.90 | 11.44 | 441 | 194695 | 27146 | 64276450 |
Pathological fracture | 376.67 | 11.44 | 270 | 194866 | 8735 | 64294861 |
Hypotension | 368.34 | 11.44 | 366 | 194770 | 380608 | 63922988 |
Loose tooth | 355.69 | 11.44 | 175 | 194961 | 2759 | 64300837 |
Musculoskeletal pain | 350.86 | 11.44 | 766 | 194370 | 80528 | 64223068 |
Hip fracture | 335.43 | 11.44 | 412 | 194724 | 26687 | 64276909 |
Condition aggravated | 334.06 | 11.44 | 381 | 194755 | 372045 | 63931551 |
Bone loss | 305.15 | 11.44 | 143 | 194993 | 2012 | 64301584 |
Breast cancer metastatic | 295.38 | 11.44 | 213 | 194923 | 6956 | 64296640 |
Overdose | 293.96 | 11.44 | 62 | 195074 | 159504 | 64144092 |
Blood calcium decreased | 288.39 | 11.44 | 371 | 194765 | 25183 | 64278413 |
Dental care | 285.86 | 11.44 | 101 | 195035 | 640 | 64302956 |
Dental caries | 281.38 | 11.44 | 245 | 194891 | 10555 | 64293041 |
Fracture | 259.82 | 11.44 | 302 | 194834 | 18453 | 64285143 |
Bone disorder | 256.17 | 11.44 | 284 | 194852 | 16475 | 64287121 |
Intentional overdose | 255.78 | 11.44 | 3 | 195133 | 89941 | 64213655 |
Neoplasm progression | 254.48 | 11.44 | 450 | 194686 | 40514 | 64263082 |
Infusion related reaction | 252.41 | 11.44 | 91 | 195045 | 164376 | 64139220 |
Mobility decreased | 243.44 | 11.44 | 689 | 194447 | 85151 | 64218445 |
Cardiac arrest | 238.54 | 11.44 | 84 | 195052 | 153980 | 64149616 |
Jaw operation | 235.17 | 11.44 | 88 | 195048 | 671 | 64302925 |
Incorrect route of product administration | 230.25 | 11.44 | 317 | 194819 | 22981 | 64280615 |
Product use in unapproved indication | 226.73 | 11.44 | 126 | 195010 | 176492 | 64127104 |
Drug intolerance | 226.04 | 11.44 | 145 | 194991 | 187847 | 64115749 |
Accidental exposure to product | 224.25 | 11.44 | 334 | 194802 | 26030 | 64277566 |
Foot fracture | 222.99 | 11.44 | 275 | 194861 | 17882 | 64285714 |
Muscle spasms | 221.19 | 11.44 | 929 | 194207 | 140094 | 64163502 |
Blood calcium increased | 218.96 | 11.44 | 192 | 194944 | 8350 | 64295246 |
Metastases to liver | 217.67 | 11.44 | 313 | 194823 | 23628 | 64279968 |
Endodontic procedure | 216.29 | 11.44 | 116 | 195020 | 2207 | 64301389 |
Exposure during pregnancy | 214.84 | 11.44 | 4 | 195132 | 77671 | 64225925 |
Exostosis of jaw | 212.72 | 11.44 | 93 | 195043 | 1101 | 64302495 |
Maternal exposure during pregnancy | 211.53 | 11.44 | 22 | 195114 | 95862 | 64207734 |
Synovitis | 207.99 | 11.44 | 27 | 195109 | 99063 | 64204533 |
Treatment failure | 207.84 | 11.44 | 49 | 195087 | 116767 | 64186829 |
Drug hypersensitivity | 203.68 | 11.44 | 252 | 194884 | 237563 | 64066033 |
Contraindicated product administered | 200.40 | 11.44 | 41 | 195095 | 107788 | 64195808 |
Confusional state | 200.19 | 11.44 | 300 | 194836 | 260844 | 64042752 |
Bradycardia | 199.92 | 11.44 | 55 | 195081 | 118164 | 64185432 |
Tooth abscess | 190.45 | 11.44 | 222 | 194914 | 13604 | 64289992 |
Product use issue | 187.92 | 11.44 | 113 | 195023 | 151602 | 64151994 |
Prostatic specific antigen increased | 183.77 | 11.44 | 176 | 194960 | 8584 | 64295012 |
Gingival pain | 183.36 | 11.44 | 153 | 194983 | 6214 | 64297382 |
Somnolence | 178.36 | 11.44 | 212 | 194924 | 203433 | 64100163 |
Osteitis | 178.20 | 11.44 | 120 | 195016 | 3502 | 64300094 |
Cardio-respiratory arrest | 175.57 | 11.44 | 41 | 195095 | 98352 | 64205244 |
Suicide attempt | 171.24 | 11.44 | 11 | 195125 | 70996 | 64232600 |
Gingival disorder | 169.83 | 11.44 | 113 | 195023 | 3231 | 64300365 |
Spinal pain | 167.78 | 11.44 | 199 | 194937 | 12422 | 64291174 |
Tachycardia | 164.43 | 11.44 | 127 | 195009 | 149452 | 64154144 |
Temporomandibular joint syndrome | 163.71 | 11.44 | 111 | 195025 | 3277 | 64300319 |
Seizure | 163.66 | 11.44 | 158 | 194978 | 166734 | 64136862 |
Gastrointestinal haemorrhage | 163.22 | 11.44 | 99 | 195037 | 132213 | 64171383 |
Dyspnoea | 163.10 | 11.44 | 1392 | 193744 | 717282 | 63586314 |
Tetany | 162.69 | 11.44 | 94 | 195042 | 2078 | 64301518 |
Abscess jaw | 161.85 | 11.44 | 85 | 195051 | 1547 | 64302049 |
Gingivitis | 160.90 | 11.44 | 154 | 194982 | 7505 | 64296091 |
Cystitis | 159.48 | 11.44 | 380 | 194756 | 42295 | 64261301 |
Coma | 159.35 | 11.44 | 35 | 195101 | 87580 | 64216016 |
Febrile neutropenia | 157.34 | 11.44 | 202 | 194934 | 187455 | 64116141 |
Malignant neoplasm progression | 155.96 | 11.44 | 716 | 194420 | 112155 | 64191441 |
Vomiting | 155.73 | 11.44 | 1003 | 194133 | 550114 | 63753482 |
Hepatic enzyme increased | 155.09 | 11.44 | 101 | 195035 | 129842 | 64173754 |
Pemphigus | 153.86 | 11.44 | 7 | 195129 | 60694 | 64242902 |
Compression fracture | 152.90 | 11.44 | 132 | 195004 | 5620 | 64297976 |
Product storage error | 152.84 | 11.44 | 195 | 194941 | 13123 | 64290473 |
Hypoglycaemia | 151.64 | 11.44 | 42 | 195094 | 89850 | 64213746 |
Stress fracture | 151.40 | 11.44 | 130 | 195006 | 5494 | 64298102 |
Therapeutic product effect decreased | 149.86 | 11.44 | 81 | 195055 | 115270 | 64188326 |
Lactic acidosis | 149.63 | 11.44 | 9 | 195127 | 61401 | 64242195 |
Respiratory failure | 147.40 | 11.44 | 162 | 194974 | 161021 | 64142575 |
Pyrexia | 145.24 | 11.44 | 1042 | 194094 | 557602 | 63745994 |
Wrist fracture | 145.18 | 11.44 | 165 | 194971 | 9836 | 64293760 |
Osteonecrosis | 145.17 | 11.44 | 286 | 194850 | 27943 | 64275653 |
Eczema | 144.33 | 11.44 | 294 | 194842 | 29426 | 64274170 |
Blood calcium abnormal | 143.72 | 11.44 | 72 | 195064 | 1182 | 64302414 |
International normalised ratio increased | 143.21 | 11.44 | 32 | 195104 | 79135 | 64224461 |
Sequestrectomy | 141.16 | 11.44 | 63 | 195073 | 786 | 64302810 |
Agitation | 140.52 | 11.44 | 46 | 195090 | 88321 | 64215275 |
Tooth infection | 140.27 | 11.44 | 196 | 194940 | 14405 | 64289191 |
Hypercalcaemia | 137.68 | 11.44 | 298 | 194838 | 31118 | 64272478 |
Hyperaesthesia teeth | 137.30 | 11.44 | 75 | 195061 | 1482 | 64302114 |
Multiple organ dysfunction syndrome | 136.51 | 11.44 | 68 | 195068 | 101345 | 64202251 |
Lower limb fracture | 136.39 | 11.44 | 186 | 194950 | 13359 | 64290237 |
Artificial crown procedure | 135.38 | 11.44 | 44 | 195092 | 207 | 64303389 |
Breast cancer | 134.10 | 11.44 | 282 | 194854 | 28866 | 64274730 |
Hypophosphataemia | 133.15 | 11.44 | 192 | 194944 | 14528 | 64289068 |
Dental restoration failure | 131.82 | 11.44 | 54 | 195082 | 537 | 64303059 |
Gingival recession | 131.35 | 11.44 | 65 | 195071 | 1038 | 64302558 |
Periodontitis | 130.38 | 11.44 | 105 | 195031 | 4054 | 64299542 |
Multiple fractures | 127.93 | 11.44 | 122 | 195014 | 5918 | 64297678 |
Pelvic fracture | 126.51 | 11.44 | 158 | 194978 | 10405 | 64293191 |
Metastases to lung | 126.40 | 11.44 | 191 | 194945 | 15073 | 64288523 |
Atypical fracture | 126.38 | 11.44 | 54 | 195082 | 602 | 64302994 |
Pneumonia | 124.86 | 11.44 | 1088 | 194048 | 558488 | 63745108 |
Depressed level of consciousness | 121.61 | 11.44 | 47 | 195089 | 81389 | 64222207 |
Gingival swelling | 120.84 | 11.44 | 98 | 195038 | 3822 | 64299774 |
Metabolic acidosis | 119.97 | 11.44 | 33 | 195103 | 70925 | 64232671 |
Oxygen saturation decreased | 119.04 | 11.44 | 90 | 195046 | 107086 | 64196510 |
Suicidal ideation | 118.16 | 11.44 | 28 | 195108 | 66514 | 64237082 |
Alanine aminotransferase increased | 117.19 | 11.44 | 149 | 194987 | 138882 | 64164714 |
Pain | 116.63 | 11.44 | 2334 | 192802 | 551177 | 63752419 |
Musculoskeletal discomfort | 115.84 | 11.44 | 190 | 194946 | 16087 | 64287509 |
Systemic lupus erythematosus | 115.56 | 11.44 | 45 | 195091 | 77567 | 64226029 |
Impaired healing | 115.47 | 11.44 | 424 | 194712 | 60049 | 64243547 |
Unresponsive to stimuli | 115.27 | 11.44 | 10 | 195126 | 50383 | 64253213 |
Intentional product use issue | 113.94 | 11.44 | 74 | 195062 | 95290 | 64208306 |
Carbohydrate antigen 15-3 increased | 111.15 | 11.44 | 56 | 195080 | 931 | 64302665 |
Hyponatraemia | 110.12 | 11.44 | 174 | 194962 | 148165 | 64155431 |
Respiratory arrest | 109.82 | 11.44 | 15 | 195121 | 52970 | 64250626 |
Joint swelling | 109.41 | 11.44 | 313 | 194823 | 215069 | 64088527 |
Abdominal pain | 107.81 | 11.44 | 532 | 194604 | 311843 | 63991753 |
Paraesthesia | 107.31 | 11.44 | 736 | 194400 | 133786 | 64169810 |
Vitamin D decreased | 106.82 | 11.44 | 124 | 195012 | 7563 | 64296033 |
Metastases to lymph nodes | 105.38 | 11.44 | 131 | 195005 | 8586 | 64295010 |
Inappropriate schedule of product administration | 105.01 | 11.44 | 554 | 194582 | 91732 | 64211864 |
Rib fracture | 104.17 | 11.44 | 227 | 194909 | 23811 | 64279785 |
Rash pruritic | 102.56 | 11.44 | 394 | 194742 | 57010 | 64246586 |
Serotonin syndrome | 101.31 | 11.44 | 4 | 195132 | 39278 | 64264318 |
Hypoxia | 100.51 | 11.44 | 72 | 195064 | 88077 | 64215519 |
Occupational exposure to product | 100.01 | 11.44 | 45 | 195091 | 573 | 64303023 |
Renal failure | 99.05 | 11.44 | 255 | 194881 | 181433 | 64122163 |
Osteonecrosis of external auditory canal | 98.88 | 11.44 | 29 | 195107 | 89 | 64303507 |
Mastication disorder | 98.72 | 11.44 | 71 | 195065 | 2308 | 64301288 |
Pericarditis | 98.58 | 11.44 | 33 | 195103 | 62483 | 64241113 |
Syncope | 96.50 | 11.44 | 208 | 194928 | 157427 | 64146169 |
Rhabdomyolysis | 95.64 | 11.44 | 82 | 195054 | 91644 | 64211952 |
Sleep disorder due to a general medical condition | 95.17 | 11.44 | 121 | 195015 | 8113 | 64295483 |
Encephalopathy | 94.60 | 11.44 | 30 | 195106 | 58789 | 64244807 |
Upper limb fracture | 94.48 | 11.44 | 165 | 194971 | 14701 | 64288895 |
Hyperkalaemia | 94.24 | 11.44 | 100 | 195036 | 101029 | 64202567 |
Product dose omission issue | 93.35 | 11.44 | 950 | 194186 | 193797 | 64109799 |
Blood pressure decreased | 92.41 | 11.44 | 75 | 195061 | 86124 | 64217472 |
Septic shock | 91.99 | 11.44 | 110 | 195026 | 105327 | 64198269 |
Bedridden | 91.64 | 11.44 | 132 | 195004 | 9977 | 64293619 |
Tumour marker increased | 91.35 | 11.44 | 79 | 195057 | 3371 | 64300225 |
Sepsis | 91.01 | 11.44 | 373 | 194763 | 229968 | 64073628 |
Weight increased | 90.35 | 11.44 | 336 | 194800 | 213012 | 64090584 |
Pancytopenia | 89.47 | 11.44 | 187 | 194949 | 143122 | 64160474 |
Fall | 89.42 | 11.44 | 1763 | 193373 | 415063 | 63888533 |
Neoplasm malignant | 88.12 | 11.44 | 216 | 194920 | 24472 | 64279124 |
Aspartate aminotransferase increased | 87.49 | 11.44 | 142 | 194994 | 119646 | 64183950 |
Drug reaction with eosinophilia and systemic symptoms | 86.58 | 11.44 | 28 | 195108 | 54189 | 64249407 |
Hospice care | 86.48 | 11.44 | 111 | 195025 | 7514 | 64296082 |
Helicobacter infection | 84.08 | 11.44 | 9 | 195127 | 38353 | 64265243 |
Anaphylactic reaction | 83.78 | 11.44 | 52 | 195084 | 68612 | 64234984 |
Toxic epidermal necrolysis | 83.33 | 11.44 | 8 | 195128 | 37158 | 64266438 |
Aggression | 82.98 | 11.44 | 19 | 195117 | 46213 | 64257383 |
Metastases to central nervous system | 82.74 | 11.44 | 150 | 194986 | 13762 | 64289834 |
Prostate cancer metastatic | 82.15 | 11.44 | 73 | 195063 | 3231 | 64300365 |
Dental operation | 81.58 | 11.44 | 45 | 195091 | 907 | 64302689 |
Gait disturbance | 80.68 | 11.44 | 836 | 194300 | 171319 | 64132277 |
Drug level increased | 80.40 | 11.44 | 6 | 195130 | 34190 | 64269406 |
Multiple sclerosis relapse | 79.89 | 11.44 | 14 | 195122 | 41121 | 64262475 |
Duodenal ulcer perforation | 78.84 | 11.44 | 7 | 195129 | 34618 | 64268978 |
Blood creatine phosphokinase increased | 77.68 | 11.44 | 40 | 195096 | 58518 | 64245078 |
Dry skin | 76.22 | 11.44 | 332 | 194804 | 50829 | 64252767 |
Psychotic disorder | 76.07 | 11.44 | 8 | 195128 | 34570 | 64269026 |
Dental fistula | 76.07 | 11.44 | 35 | 195101 | 471 | 64303125 |
Hand deformity | 75.94 | 11.44 | 48 | 195088 | 62723 | 64240873 |
Gingival abscess | 75.39 | 11.44 | 39 | 195097 | 687 | 64302909 |
Femoral neck fracture | 74.85 | 11.44 | 111 | 195025 | 8613 | 64294983 |
Intentional self-injury | 74.76 | 11.44 | 3 | 195133 | 29041 | 64274555 |
Jaw fistula | 74.35 | 11.44 | 23 | 195113 | 89 | 64303507 |
Loss of consciousness | 74.28 | 11.44 | 217 | 194919 | 148148 | 64155448 |
Coronary artery disease | 73.41 | 11.44 | 46 | 195090 | 60387 | 64243209 |
Wound | 73.08 | 11.44 | 74 | 195062 | 76403 | 64227193 |
Hyperparathyroidism | 72.88 | 11.44 | 64 | 195072 | 2788 | 64300808 |
Fractured sacrum | 72.88 | 11.44 | 49 | 195087 | 1426 | 64302170 |
Myocardial infarction | 71.60 | 11.44 | 259 | 194877 | 165562 | 64138034 |
Tooth erosion | 71.13 | 11.44 | 31 | 195105 | 364 | 64303232 |
Chest pain | 70.80 | 11.44 | 421 | 194715 | 235559 | 64068037 |
Body height decreased | 70.47 | 11.44 | 100 | 195036 | 7454 | 64296142 |
Metastases to spine | 70.44 | 11.44 | 70 | 195066 | 3573 | 64300023 |
Wheezing | 70.35 | 11.44 | 84 | 195052 | 80495 | 64223101 |
Joint noise | 70.18 | 11.44 | 66 | 195070 | 3145 | 64300451 |
Hallucination | 70.05 | 11.44 | 70 | 195066 | 72718 | 64230878 |
Sciatica | 69.90 | 11.44 | 175 | 194961 | 20089 | 64283507 |
Orthostatic hypotension | 69.73 | 11.44 | 27 | 195109 | 46711 | 64256885 |
Neck pain | 69.71 | 11.44 | 369 | 194767 | 61164 | 64242432 |
Eosinophilia | 69.64 | 11.44 | 15 | 195121 | 38061 | 64265535 |
Rheumatoid arthritis | 68.72 | 11.44 | 260 | 194876 | 164034 | 64139562 |
Mental status changes | 68.36 | 11.44 | 51 | 195085 | 61111 | 64242485 |
Pulpitis dental | 68.18 | 11.44 | 41 | 195095 | 978 | 64302618 |
Hot flush | 67.32 | 11.44 | 298 | 194838 | 45937 | 64257659 |
Influenza like illness | 67.17 | 11.44 | 366 | 194770 | 61336 | 64242260 |
Chest discomfort | 65.54 | 11.44 | 160 | 194976 | 115946 | 64187650 |
Cytomegalovirus infection | 65.36 | 11.44 | 16 | 195120 | 37183 | 64266413 |
Sedation | 65.17 | 11.44 | 22 | 195114 | 41440 | 64262156 |
Tibia fracture | 65.03 | 11.44 | 76 | 195060 | 4669 | 64298927 |
Oral pain | 64.04 | 11.44 | 206 | 194930 | 27287 | 64276309 |
Folliculitis | 63.56 | 11.44 | 8 | 195128 | 30069 | 64273527 |
Dysarthria | 63.28 | 11.44 | 52 | 195084 | 59354 | 64244242 |
Psoriatic arthropathy | 62.94 | 11.44 | 26 | 195110 | 43255 | 64260341 |
Delirium | 62.71 | 11.44 | 70 | 195066 | 69124 | 64234472 |
Incorrect dose administered | 62.51 | 11.44 | 55 | 195081 | 60710 | 64242886 |
Glossodynia | 62.50 | 11.44 | 62 | 195074 | 64634 | 64238962 |
Haematemesis | 62.50 | 11.44 | 32 | 195104 | 46967 | 64256629 |
Drug withdrawal syndrome | 62.21 | 11.44 | 10 | 195126 | 31281 | 64272315 |
C-telopeptide increased | 61.60 | 11.44 | 14 | 195122 | 7 | 64303589 |
Dermatitis | 61.45 | 11.44 | 155 | 194981 | 17874 | 64285722 |
Generalised tonic-clonic seizure | 61.18 | 11.44 | 22 | 195114 | 39835 | 64263761 |
Abortion spontaneous | 60.30 | 11.44 | 4 | 195132 | 25139 | 64278457 |
Heart rate decreased | 60.16 | 11.44 | 47 | 195089 | 55020 | 64248576 |
Scoliosis | 58.95 | 11.44 | 82 | 195054 | 6000 | 64297596 |
Acute respiratory distress syndrome | 58.91 | 11.44 | 22 | 195114 | 38913 | 64264683 |
Humerus fracture | 58.77 | 11.44 | 94 | 195042 | 7791 | 64295805 |
Metastasis | 58.54 | 11.44 | 79 | 195057 | 5616 | 64297980 |
Muscle injury | 58.46 | 11.44 | 6 | 195130 | 26431 | 64277165 |
Dental necrosis | 58.40 | 11.44 | 21 | 195115 | 141 | 64303455 |
Walking aid user | 58.38 | 11.44 | 83 | 195053 | 6198 | 64297398 |
Dental cleaning | 58.10 | 11.44 | 14 | 195122 | 13 | 64303583 |
Respiratory distress | 58.02 | 11.44 | 44 | 195092 | 52287 | 64251309 |
Ear pain | 57.33 | 11.44 | 187 | 194949 | 24949 | 64278647 |
Dehydration | 57.23 | 11.44 | 402 | 194734 | 216361 | 64087235 |
Bone lesion | 57.03 | 11.44 | 74 | 195062 | 5063 | 64298533 |
Emotional distress | 56.85 | 11.44 | 19 | 195117 | 36019 | 64267577 |
Thrombocytopenia | 56.21 | 11.44 | 421 | 194715 | 223380 | 64080216 |
Adverse drug reaction | 55.92 | 11.44 | 279 | 194857 | 45185 | 64258411 |
Cardiac failure congestive | 55.67 | 11.44 | 205 | 194931 | 130375 | 64173221 |
Headache | 55.09 | 11.44 | 1202 | 193934 | 528265 | 63775331 |
Labelled drug-drug interaction medication error | 54.45 | 11.44 | 3 | 195133 | 22059 | 64281537 |
Tremor | 54.25 | 11.44 | 247 | 194889 | 147983 | 64155613 |
C-reactive protein abnormal | 54.04 | 11.44 | 11 | 195125 | 29036 | 64274560 |
Oedema | 54.03 | 11.44 | 124 | 195012 | 91811 | 64211785 |
Blood glucose increased | 53.91 | 11.44 | 137 | 194999 | 97936 | 64205660 |
Ventricular fibrillation | 53.85 | 11.44 | 5 | 195131 | 23855 | 64279741 |
Atrial fibrillation | 53.56 | 11.44 | 301 | 194835 | 170788 | 64132808 |
Blood bilirubin increased | 53.51 | 11.44 | 57 | 195079 | 57496 | 64246100 |
Living in residential institution | 53.13 | 11.44 | 29 | 195107 | 572 | 64303024 |
Drug-induced liver injury | 52.89 | 11.44 | 40 | 195096 | 47603 | 64255993 |
Nausea | 52.32 | 11.44 | 1899 | 193237 | 783901 | 63519695 |
Blood creatinine increased | 52.27 | 11.44 | 222 | 194914 | 135560 | 64168036 |
Device expulsion | 51.78 | 11.44 | 3 | 195133 | 21133 | 64282463 |
Liver function test abnormal | 51.77 | 11.44 | 62 | 195074 | 59339 | 64244257 |
Intentional product misuse | 51.56 | 11.44 | 87 | 195049 | 72208 | 64231388 |
Acute myocardial infarction | 51.50 | 11.44 | 82 | 195054 | 69636 | 64233960 |
Cardiogenic shock | 51.32 | 11.44 | 17 | 195119 | 32410 | 64271186 |
Circulatory collapse | 51.13 | 11.44 | 19 | 195117 | 33713 | 64269883 |
Musculoskeletal chest pain | 50.99 | 11.44 | 162 | 194974 | 21317 | 64282279 |
Poisoning | 50.98 | 11.44 | 4 | 195132 | 21875 | 64281721 |
Tooth resorption | 50.80 | 11.44 | 13 | 195123 | 19 | 64303577 |
Ventricular tachycardia | 50.78 | 11.44 | 20 | 195116 | 34245 | 64269351 |
Stevens-Johnson syndrome | 50.74 | 11.44 | 20 | 195116 | 34229 | 64269367 |
Sinus tachycardia | 50.73 | 11.44 | 17 | 195119 | 32171 | 64271425 |
Parathyroid disorder | 50.36 | 11.44 | 25 | 195111 | 402 | 64303194 |
Angioedema | 50.27 | 11.44 | 68 | 195068 | 61753 | 64241843 |
Denture wearer | 50.16 | 11.44 | 16 | 195120 | 70 | 64303526 |
Haematochezia | 50.04 | 11.44 | 77 | 195059 | 66296 | 64237300 |
Alopecia | 50.04 | 11.44 | 741 | 194395 | 164949 | 64138647 |
Product prescribing error | 49.98 | 11.44 | 22 | 195114 | 35247 | 64268349 |
Dental discomfort | 49.89 | 11.44 | 23 | 195113 | 311 | 64303285 |
Haemoglobin decreased | 49.42 | 11.44 | 366 | 194770 | 194697 | 64108899 |
White blood cell count increased | 49.37 | 11.44 | 77 | 195059 | 65937 | 64237659 |
Lower respiratory tract infection | 49.09 | 11.44 | 136 | 195000 | 94478 | 64209118 |
Renal tubular necrosis | 48.93 | 11.44 | 5 | 195131 | 22105 | 64281491 |
Drug dependence | 48.46 | 11.44 | 20 | 195116 | 33292 | 64270304 |
Hypersensitivity | 48.17 | 11.44 | 372 | 194764 | 196080 | 64107516 |
Arthritis | 48.13 | 11.44 | 425 | 194711 | 83389 | 64220207 |
Pulmonary oedema | 47.96 | 11.44 | 104 | 195032 | 78570 | 64225026 |
Vitamin D abnormal | 47.68 | 11.44 | 17 | 195119 | 111 | 64303485 |
Abnormal behaviour | 47.61 | 11.44 | 21 | 195115 | 33601 | 64269995 |
Blood pressure increased | 47.02 | 11.44 | 317 | 194819 | 172235 | 64131361 |
Anxiety | 46.80 | 11.44 | 390 | 194746 | 202259 | 64101337 |
Blood phosphorus decreased | 46.68 | 11.44 | 71 | 195065 | 5634 | 64297962 |
Shock | 46.59 | 11.44 | 29 | 195107 | 38211 | 64265385 |
Hypoaesthesia | 46.35 | 11.44 | 633 | 194503 | 138475 | 64165121 |
Osteoporosis | 46.06 | 11.44 | 250 | 194886 | 41830 | 64261766 |
Jaw fracture | 45.86 | 11.44 | 49 | 195087 | 2725 | 64300871 |
Respiratory depression | 45.48 | 11.44 | 8 | 195128 | 23435 | 64280161 |
Status epilepticus | 45.20 | 11.44 | 6 | 195130 | 21657 | 64281939 |
Coagulopathy | 45.10 | 11.44 | 20 | 195116 | 31900 | 64271696 |
Drug ineffective for unapproved indication | 44.79 | 11.44 | 19 | 195117 | 31114 | 64272482 |
Oral cavity fistula | 44.72 | 11.44 | 27 | 195109 | 649 | 64302947 |
Polymyalgia rheumatica | 44.70 | 11.44 | 53 | 195083 | 3306 | 64300290 |
Hand fracture | 44.70 | 11.44 | 64 | 195072 | 4810 | 64298786 |
Right ventricular failure | 44.68 | 11.44 | 6 | 195130 | 21465 | 64282131 |
Extrapyramidal disorder | 44.39 | 11.44 | 4 | 195132 | 19548 | 64284048 |
Blood pressure fluctuation | 44.29 | 11.44 | 55 | 195081 | 51816 | 64251780 |
Spinal operation | 44.19 | 11.44 | 72 | 195064 | 6061 | 64297535 |
Hypervolaemia | 43.99 | 11.44 | 31 | 195105 | 38254 | 64265342 |
Spinal deformity | 43.80 | 11.44 | 29 | 195107 | 822 | 64302774 |
Medication error | 43.70 | 11.44 | 52 | 195084 | 49914 | 64253682 |
Hyperparathyroidism secondary | 43.63 | 11.44 | 44 | 195092 | 2286 | 64301310 |
Haematocrit decreased | 43.55 | 11.44 | 61 | 195075 | 54594 | 64249002 |
Bronchopulmonary aspergillosis | 43.07 | 11.44 | 4 | 195132 | 19081 | 64284515 |
Accidental overdose | 42.93 | 11.44 | 24 | 195112 | 33533 | 64270063 |
Cytokine release syndrome | 42.92 | 11.44 | 6 | 195130 | 20823 | 64282773 |
Hyperhidrosis | 42.87 | 11.44 | 213 | 194923 | 124707 | 64178889 |
Agranulocytosis | 42.56 | 11.44 | 32 | 195104 | 38197 | 64265399 |
Pulmonary arterial hypertension | 42.49 | 11.44 | 12 | 195124 | 25355 | 64278241 |
C-reactive protein increased | 42.44 | 11.44 | 146 | 194990 | 94763 | 64208833 |
Mouth swelling | 42.42 | 11.44 | 64 | 195072 | 5043 | 64298553 |
Pancreatitis | 42.26 | 11.44 | 72 | 195064 | 59535 | 64244061 |
Heart rate increased | 41.99 | 11.44 | 155 | 194981 | 98520 | 64205076 |
Radius fracture | 41.98 | 11.44 | 50 | 195086 | 3134 | 64300462 |
Tachypnoea | 41.93 | 11.44 | 14 | 195122 | 26557 | 64277039 |
Blood parathyroid hormone abnormal | 41.90 | 11.44 | 21 | 195115 | 345 | 64303251 |
Liver injury | 41.90 | 11.44 | 19 | 195117 | 29913 | 64273683 |
Palliative care | 41.80 | 11.44 | 26 | 195110 | 660 | 64302936 |
Hemiparesis | 41.65 | 11.44 | 19 | 195117 | 29808 | 64273788 |
Osteoarthritis | 41.60 | 11.44 | 331 | 194805 | 63005 | 64240591 |
Flushing | 41.59 | 11.44 | 112 | 195024 | 78536 | 64225060 |
Product quality issue | 41.58 | 11.44 | 19 | 195117 | 29780 | 64273816 |
Dyskinesia | 41.30 | 11.44 | 35 | 195101 | 39353 | 64264243 |
Oral infection | 41.30 | 11.44 | 61 | 195075 | 4716 | 64298880 |
Pneumocystis jirovecii pneumonia | 41.16 | 11.44 | 16 | 195120 | 27618 | 64275978 |
Abdominal discomfort | 41.14 | 11.44 | 353 | 194783 | 181969 | 64121627 |
Deep vein thrombosis | 41.07 | 11.44 | 171 | 194965 | 105011 | 64198585 |
Transplant rejection | 41.06 | 11.44 | 3 | 195133 | 17398 | 64286198 |
Torsade de pointes | 40.95 | 11.44 | 3 | 195133 | 17360 | 64286236 |
Bone marrow failure | 40.78 | 11.44 | 51 | 195085 | 47901 | 64255695 |
Acute myeloid leukaemia | 40.74 | 11.44 | 16 | 195120 | 27447 | 64276149 |
Haematoma | 40.59 | 11.44 | 48 | 195088 | 46202 | 64257394 |
Melaena | 40.48 | 11.44 | 62 | 195074 | 53486 | 64250110 |
Parathyroidectomy | 40.31 | 11.44 | 17 | 195119 | 183 | 64303413 |
Injury | 40.28 | 11.44 | 67 | 195069 | 55925 | 64247671 |
No adverse event | 40.18 | 11.44 | 18 | 195118 | 28543 | 64275053 |
Noninfective gingivitis | 39.95 | 11.44 | 33 | 195103 | 1321 | 64302275 |
Therapeutic response decreased | 39.86 | 11.44 | 60 | 195076 | 52128 | 64251468 |
Staphylococcal infection | 38.96 | 11.44 | 58 | 195078 | 50620 | 64252976 |
Feeling abnormal | 38.96 | 11.44 | 594 | 194542 | 133008 | 64170588 |
Injection site erythema | 38.83 | 11.44 | 99 | 195037 | 70701 | 64232895 |
Paraesthesia oral | 38.75 | 11.44 | 107 | 195029 | 13024 | 64290572 |
Bone swelling | 38.73 | 11.44 | 31 | 195105 | 1186 | 64302410 |
Fluid retention | 38.69 | 11.44 | 76 | 195060 | 59530 | 64244066 |
Hormone-refractory prostate cancer | 38.68 | 11.44 | 20 | 195116 | 352 | 64303244 |
Osteoporotic fracture | 38.65 | 11.44 | 51 | 195085 | 3547 | 64300049 |
Infection | 38.63 | 11.44 | 365 | 194771 | 184515 | 64119081 |
Diarrhoea | 38.35 | 11.44 | 1792 | 193344 | 720912 | 63582684 |
Hepatic failure | 38.28 | 11.44 | 68 | 195068 | 55326 | 64248270 |
Tubulointerstitial nephritis | 38.27 | 11.44 | 23 | 195113 | 30886 | 64272710 |
Oral surgery | 38.22 | 11.44 | 28 | 195108 | 937 | 64302659 |
Disorientation | 38.16 | 11.44 | 69 | 195067 | 55759 | 64247837 |
Aspergillus infection | 38.15 | 11.44 | 3 | 195133 | 16376 | 64287220 |
Cyanosis | 38.01 | 11.44 | 10 | 195126 | 22145 | 64281451 |
Red blood cell sedimentation rate abnormal | 37.94 | 11.44 | 3 | 195133 | 16303 | 64287293 |
Oedema peripheral | 37.90 | 11.44 | 430 | 194706 | 209887 | 64093709 |
Nerve compression | 37.64 | 11.44 | 75 | 195061 | 7386 | 64296210 |
Blood urea increased | 37.51 | 11.44 | 47 | 195089 | 44106 | 64259490 |
Psoriasis | 37.25 | 11.44 | 103 | 195033 | 71600 | 64231996 |
Diabetic ketoacidosis | 37.24 | 11.44 | 22 | 195114 | 29823 | 64273773 |
Type 2 diabetes mellitus | 37.21 | 11.44 | 29 | 195107 | 33991 | 64269605 |
Hallucination, auditory | 37.05 | 11.44 | 4 | 195132 | 16935 | 64286661 |
Acute respiratory failure | 36.62 | 11.44 | 59 | 195077 | 49875 | 64253721 |
Pulmonary hypertension | 36.56 | 11.44 | 46 | 195090 | 43093 | 64260503 |
Restlessness | 36.32 | 11.44 | 40 | 195096 | 39745 | 64263851 |
Injection site reaction | 36.27 | 11.44 | 53 | 195083 | 46611 | 64256985 |
Respiratory rate increased | 36.12 | 11.44 | 6 | 195130 | 18325 | 64285271 |
Adverse reaction | 36.08 | 11.44 | 75 | 195061 | 7612 | 64295984 |
Bone graft | 36.06 | 11.44 | 23 | 195113 | 611 | 64302985 |
Onychoclasis | 35.96 | 11.44 | 56 | 195080 | 4536 | 64299060 |
Metastases to skin | 35.94 | 11.44 | 32 | 195104 | 1420 | 64302176 |
Device failure | 35.94 | 11.44 | 63 | 195073 | 5629 | 64297967 |
Jaundice | 35.88 | 11.44 | 57 | 195079 | 48455 | 64255141 |
Pneumonia aspiration | 35.59 | 11.44 | 79 | 195057 | 59192 | 64244404 |
Disease recurrence | 35.56 | 11.44 | 26 | 195110 | 31484 | 64272112 |
Leukocytosis | 35.50 | 11.44 | 37 | 195099 | 37703 | 64265893 |
Renal injury | 35.45 | 11.44 | 3 | 195133 | 15426 | 64288170 |
Menopausal symptoms | 35.36 | 11.44 | 33 | 195103 | 1557 | 64302039 |
Obstructive airways disorder | 35.24 | 11.44 | 13 | 195123 | 23172 | 64280424 |
Vitamin D deficiency | 35.23 | 11.44 | 96 | 195040 | 11596 | 64292000 |
Cancer pain | 34.86 | 11.44 | 53 | 195083 | 4204 | 64299392 |
PIK3CA-activated mutation | 34.81 | 11.44 | 21 | 195115 | 504 | 64303092 |
Asthma | 34.63 | 11.44 | 159 | 194977 | 95066 | 64208530 |
Musculoskeletal disorder | 34.54 | 11.44 | 126 | 195010 | 17780 | 64285816 |
Withdrawal syndrome | 34.34 | 11.44 | 14 | 195122 | 23478 | 64280118 |
Ataxia | 34.22 | 11.44 | 12 | 195124 | 22072 | 64281524 |
Hallucination, visual | 34.06 | 11.44 | 21 | 195115 | 27813 | 64275783 |
Hypothermia | 34.00 | 11.44 | 9 | 195127 | 19847 | 64283749 |
Haemodynamic instability | 33.99 | 11.44 | 3 | 195133 | 14909 | 64288687 |
Bone giant cell tumour malignant | 33.63 | 11.44 | 7 | 195129 | 0 | 64303596 |
Irritability | 33.48 | 11.44 | 37 | 195099 | 36709 | 64266887 |
Parathyroid tumour malignant | 33.32 | 11.44 | 10 | 195126 | 34 | 64303562 |
Angina pectoris | 33.31 | 11.44 | 53 | 195083 | 45028 | 64258568 |
Hepatitis | 33.29 | 11.44 | 54 | 195082 | 45528 | 64258068 |
Paranoia | 33.02 | 11.44 | 5 | 195131 | 16347 | 64287249 |
Pancreatitis acute | 32.99 | 11.44 | 49 | 195087 | 42806 | 64260790 |
Angina unstable | 32.96 | 11.44 | 4 | 195132 | 15463 | 64288133 |
Gingival operation | 32.66 | 11.44 | 11 | 195125 | 59 | 64303537 |
Premature delivery | 32.64 | 11.44 | 8 | 195128 | 18581 | 64285015 |
Upper gastrointestinal haemorrhage | 32.60 | 11.44 | 35 | 195101 | 35185 | 64268411 |
Swelling | 32.33 | 11.44 | 319 | 194817 | 159899 | 64143697 |
Sinusitis | 32.26 | 11.44 | 284 | 194852 | 145644 | 64157952 |
Gingival erythema | 32.15 | 11.44 | 20 | 195116 | 508 | 64303088 |
Cataract operation | 32.04 | 11.44 | 48 | 195088 | 3758 | 64299838 |
Shock haemorrhagic | 31.99 | 11.44 | 6 | 195130 | 16785 | 64286811 |
Cognitive disorder | 31.80 | 11.44 | 75 | 195061 | 55012 | 64248584 |
Muscle spasticity | 31.66 | 11.44 | 6 | 195130 | 16663 | 64286933 |
Intervertebral disc protrusion | 31.58 | 11.44 | 133 | 195003 | 20058 | 64283538 |
Prescribed overdose | 31.58 | 11.44 | 11 | 195125 | 20320 | 64283276 |
Lymphoedema | 31.53 | 11.44 | 83 | 195053 | 9822 | 64293774 |
Prostate cancer | 31.44 | 11.44 | 131 | 195005 | 19664 | 64283932 |
Haemoptysis | 31.44 | 11.44 | 63 | 195073 | 48985 | 64254611 |
Hyperglycaemia | 31.35 | 11.44 | 88 | 195048 | 60880 | 64242716 |
Cardiac failure | 31.34 | 11.44 | 253 | 194883 | 132120 | 64171476 |
Drug resistance | 31.27 | 11.44 | 36 | 195100 | 35066 | 64268530 |
Dental prosthesis user | 30.84 | 11.44 | 9 | 195127 | 27 | 64303569 |
Hepatocellular injury | 30.83 | 11.44 | 56 | 195080 | 45179 | 64258417 |
Pseudomonas infection | 30.82 | 11.44 | 8 | 195128 | 17875 | 64285721 |
Haemorrhage intracranial | 30.67 | 11.44 | 17 | 195119 | 23867 | 64279729 |
Myoclonus | 30.66 | 11.44 | 19 | 195117 | 25099 | 64278497 |
Acidosis | 30.59 | 11.44 | 8 | 195128 | 17787 | 64285809 |
Bone fissure | 30.58 | 11.44 | 13 | 195123 | 143 | 64303453 |
Mastectomy | 30.43 | 11.44 | 25 | 195111 | 993 | 64302603 |
Dental prosthesis placement | 30.38 | 11.44 | 8 | 195128 | 14 | 64303582 |
Aphasia | 30.31 | 11.44 | 48 | 195088 | 40858 | 64262738 |
Pallor | 30.19 | 11.44 | 44 | 195092 | 38737 | 64264859 |
Peri-implantitis | 30.13 | 11.44 | 9 | 195127 | 30 | 64303566 |
Intercepted medication error | 30.12 | 11.44 | 22 | 195114 | 733 | 64302863 |
Red blood cell sedimentation rate increased | 30.09 | 11.44 | 30 | 195106 | 31205 | 64272391 |
Hepatic encephalopathy | 30.07 | 11.44 | 13 | 195123 | 21053 | 64282543 |
Periodontal disease | 29.97 | 11.44 | 31 | 195105 | 1660 | 64301936 |
Sinus bradycardia | 29.82 | 11.44 | 16 | 195120 | 22877 | 64280719 |
Dysstasia | 29.64 | 11.44 | 144 | 194992 | 23071 | 64280525 |
Oral discomfort | 29.41 | 11.44 | 73 | 195063 | 8333 | 64295263 |
Muscle tightness | 29.33 | 11.44 | 87 | 195049 | 11028 | 64292568 |
Delusion | 29.30 | 11.44 | 9 | 195127 | 18005 | 64285591 |
Calcinosis | 29.19 | 11.44 | 33 | 195103 | 1955 | 64301641 |
Haemorrhage | 29.15 | 11.44 | 132 | 195004 | 79219 | 64224377 |
Diabetes mellitus inadequate control | 29.12 | 11.44 | 14 | 195122 | 21307 | 64282289 |
Abscess oral | 29.10 | 11.44 | 26 | 195110 | 1159 | 64302437 |
Back disorder | 29.08 | 11.44 | 81 | 195055 | 9909 | 64293687 |
Acute coronary syndrome | 29.06 | 11.44 | 11 | 195125 | 19299 | 64284297 |
Hepatic cytolysis | 29.06 | 11.44 | 4 | 195132 | 14045 | 64289551 |
Ulna fracture | 28.82 | 11.44 | 24 | 195112 | 972 | 64302624 |
Haemodialysis | 28.75 | 11.44 | 8 | 195128 | 17069 | 64286527 |
Weight bearing difficulty | 28.56 | 11.44 | 38 | 195098 | 2665 | 64300931 |
Urinary tract infection | 28.40 | 11.44 | 909 | 194227 | 230687 | 64072909 |
Hypokalaemia | 28.40 | 11.44 | 234 | 194902 | 121669 | 64181927 |
Haemophagocytic lymphohistiocytosis | 28.28 | 11.44 | 9 | 195127 | 17600 | 64285996 |
Anuria | 28.21 | 11.44 | 11 | 195125 | 18953 | 64284643 |
Hypoaesthesia oral | 28.09 | 11.44 | 88 | 195048 | 11492 | 64292104 |
Exostosis | 27.82 | 11.44 | 87 | 195049 | 11351 | 64292245 |
Decreased immune responsiveness | 27.78 | 11.44 | 49 | 195087 | 4399 | 64299197 |
Altered state of consciousness | 27.59 | 11.44 | 45 | 195091 | 37857 | 64265739 |
Rehabilitation therapy | 27.52 | 11.44 | 28 | 195108 | 1470 | 64302126 |
Adverse event | 27.38 | 11.44 | 209 | 194927 | 39280 | 64264316 |
Metastases to meninges | 27.35 | 11.44 | 38 | 195098 | 2777 | 64300819 |
COVID-19 | 27.27 | 11.44 | 103 | 195033 | 65037 | 64238559 |
Posterior reversible encephalopathy syndrome | 27.13 | 11.44 | 18 | 195118 | 22928 | 64280668 |
Cholesteatoma | 27.06 | 11.44 | 11 | 195125 | 107 | 64303489 |
Bronchospasm | 27.03 | 11.44 | 16 | 195120 | 21666 | 64281930 |
Parathyroid tumour | 26.98 | 11.44 | 10 | 195126 | 74 | 64303522 |
Unevaluable event | 26.93 | 11.44 | 252 | 194884 | 50237 | 64253359 |
Hyperthermia | 26.71 | 11.44 | 7 | 195129 | 15543 | 64288053 |
Depression | 26.63 | 11.44 | 392 | 194744 | 182899 | 64120697 |
Hip surgery | 26.48 | 11.44 | 35 | 195101 | 2438 | 64301158 |
Hungry bone syndrome | 26.45 | 11.44 | 12 | 195124 | 156 | 64303440 |
Forearm fracture | 26.44 | 11.44 | 17 | 195119 | 458 | 64303138 |
Acute hepatic failure | 26.41 | 11.44 | 24 | 195112 | 26088 | 64277508 |
Dizziness | 26.40 | 11.44 | 1049 | 194087 | 429114 | 63874482 |
Device fastener issue | 26.32 | 11.44 | 7 | 195129 | 13 | 64303583 |
Ankle fracture | 26.29 | 11.44 | 101 | 195035 | 14609 | 64288987 |
Vitamin D increased | 26.28 | 11.44 | 17 | 195119 | 463 | 64303133 |
Abdominal lymphadenopathy | 26.26 | 11.44 | 24 | 195112 | 1102 | 64302494 |
Osteolysis | 25.99 | 11.44 | 37 | 195099 | 2766 | 64300830 |
Kyphosis | 25.83 | 11.44 | 34 | 195102 | 2359 | 64301237 |
Photophobia | 25.78 | 11.44 | 10 | 195126 | 17283 | 64286313 |
Activated partial thromboplastin time prolonged | 25.73 | 11.44 | 4 | 195132 | 12827 | 64290769 |
Metaphyseal corner fracture | 25.65 | 11.44 | 8 | 195128 | 32 | 64303564 |
Nightmare | 25.46 | 11.44 | 16 | 195120 | 20977 | 64282619 |
Rash macular | 25.43 | 11.44 | 140 | 194996 | 23545 | 64280051 |
Adnexa uteri mass | 25.39 | 11.44 | 14 | 195122 | 282 | 64303314 |
Subarachnoid haemorrhage | 25.35 | 11.44 | 12 | 195124 | 18426 | 64285170 |
Ascites | 25.33 | 11.44 | 99 | 195037 | 61902 | 64241694 |
Myocardial ischaemia | 25.20 | 11.44 | 20 | 195116 | 23231 | 64280365 |
Brain oedema | 25.19 | 11.44 | 18 | 195118 | 22057 | 64281539 |
Pathogen resistance | 24.95 | 11.44 | 4 | 195132 | 12539 | 64291057 |
Limb discomfort | 24.88 | 11.44 | 154 | 194982 | 27021 | 64276575 |
Progressive multifocal leukoencephalopathy | 24.86 | 11.44 | 12 | 195124 | 18220 | 64285376 |
Bone resorption test abnormal | 24.68 | 11.44 | 6 | 195130 | 6 | 64303590 |
Immune system disorder | 24.55 | 11.44 | 72 | 195064 | 9069 | 64294527 |
Lung neoplasm malignant | 24.54 | 11.44 | 129 | 195007 | 21319 | 64282277 |
Device dislocation | 24.52 | 11.44 | 17 | 195119 | 21161 | 64282435 |
Rectal haemorrhage | 24.44 | 11.44 | 100 | 195036 | 61717 | 64241879 |
Bone formation increased | 24.24 | 11.44 | 9 | 195127 | 67 | 64303529 |
Thrombotic microangiopathy | 24.22 | 11.44 | 10 | 195126 | 16645 | 64286951 |
Osteocalcin decreased | 24.21 | 11.44 | 6 | 195130 | 7 | 64303589 |
Rales | 24.07 | 11.44 | 8 | 195128 | 15221 | 64288375 |
Oral neoplasm benign | 24.02 | 11.44 | 5 | 195131 | 0 | 64303596 |
Calcium ionised abnormal | 24.02 | 11.44 | 5 | 195131 | 0 | 64303596 |
Myelosuppression | 23.99 | 11.44 | 22 | 195114 | 23808 | 64279788 |
Therapy non-responder | 23.98 | 11.44 | 110 | 195026 | 65789 | 64237807 |
Nasopharyngitis | 23.96 | 11.44 | 433 | 194703 | 195640 | 64107956 |
Transaminases increased | 23.95 | 11.44 | 63 | 195073 | 44531 | 64259065 |
Rash papular | 23.93 | 11.44 | 109 | 195027 | 17004 | 64286592 |
Hepatitis cholestatic | 23.90 | 11.44 | 4 | 195132 | 12151 | 64291445 |
Nasal congestion | 23.90 | 11.44 | 96 | 195040 | 59562 | 64244034 |
Injection site pruritus | 23.89 | 11.44 | 49 | 195087 | 37777 | 64265819 |
Blood cholesterol increased | 23.83 | 11.44 | 244 | 194892 | 49822 | 64253774 |
Bone deformity | 23.75 | 11.44 | 13 | 195123 | 258 | 64303338 |
Root canal infection | 23.66 | 11.44 | 13 | 195123 | 260 | 64303336 |
Anger | 23.63 | 11.44 | 9 | 195127 | 15732 | 64287864 |
Bone sequestrum | 23.55 | 11.44 | 23 | 195113 | 1149 | 64302447 |
Bacteraemia | 23.54 | 11.44 | 28 | 195108 | 26883 | 64276713 |
Bone cancer | 23.43 | 11.44 | 26 | 195110 | 1509 | 64302087 |
Gingival injury | 23.28 | 11.44 | 7 | 195129 | 24 | 64303572 |
Atelectasis | 23.18 | 11.44 | 29 | 195107 | 27237 | 64276359 |
Obesity | 23.16 | 11.44 | 17 | 195119 | 20545 | 64283051 |
Proteinuria | 23.04 | 11.44 | 30 | 195106 | 27693 | 64275903 |
Basal cell carcinoma | 23.02 | 11.44 | 36 | 195100 | 30802 | 64272794 |
Blood alkaline phosphatase decreased | 22.92 | 11.44 | 26 | 195110 | 1546 | 64302050 |
Disturbance in attention | 22.85 | 11.44 | 57 | 195079 | 41017 | 64262579 |
Bone fistula | 22.85 | 11.44 | 9 | 195127 | 80 | 64303516 |
Parathyroid tumour benign | 22.82 | 11.44 | 18 | 195118 | 674 | 64302922 |
Subdural haematoma | 22.66 | 11.44 | 31 | 195105 | 28023 | 64275573 |
Lower gastrointestinal haemorrhage | 22.60 | 11.44 | 7 | 195129 | 13932 | 64289664 |
Haematuria | 22.56 | 11.44 | 100 | 195036 | 60371 | 64243225 |
Cerebral haemorrhage | 22.56 | 11.44 | 79 | 195057 | 51011 | 64252585 |
Presyncope | 22.55 | 11.44 | 45 | 195091 | 35044 | 64268552 |
Dementia | 22.47 | 11.44 | 123 | 195013 | 20643 | 64282953 |
Pulmonary haemorrhage | 22.33 | 11.44 | 6 | 195130 | 13103 | 64290493 |
Akathisia | 22.17 | 11.44 | 4 | 195132 | 11506 | 64292090 |
Hepatic lesion | 21.90 | 11.44 | 52 | 195084 | 5772 | 64297824 |
Nephropathy toxic | 21.73 | 11.44 | 13 | 195123 | 17501 | 64286095 |
Tartrate-resistant acid phosphatase increased | 21.68 | 11.44 | 5 | 195131 | 3 | 64303593 |
Vertebroplasty | 21.66 | 11.44 | 12 | 195124 | 244 | 64303352 |
Muscle rigidity | 21.63 | 11.44 | 13 | 195123 | 17460 | 64286136 |
Anaemia | 21.62 | 11.44 | 931 | 194205 | 377749 | 63925847 |
Gingival ulceration | 21.57 | 11.44 | 19 | 195117 | 831 | 64302765 |
Hepatic steatosis | 21.48 | 11.44 | 38 | 195098 | 30969 | 64272627 |
Quality of life decreased | 21.46 | 11.44 | 62 | 195074 | 7744 | 64295852 |
Heart rate irregular | 21.44 | 11.44 | 31 | 195105 | 27382 | 64276214 |
Gamma-glutamyltransferase increased | 21.43 | 11.44 | 75 | 195061 | 48435 | 64255161 |
Hypovolaemia | 21.41 | 11.44 | 10 | 195126 | 15476 | 64288120 |
Dysgeusia | 21.31 | 11.44 | 227 | 194909 | 46820 | 64256776 |
Breast cancer recurrent | 20.93 | 11.44 | 32 | 195104 | 2551 | 64301045 |
Trismus | 20.91 | 11.44 | 46 | 195090 | 4855 | 64298741 |
Sudden death | 20.89 | 11.44 | 18 | 195118 | 20078 | 64283518 |
Inappropriate antidiuretic hormone secretion | 20.80 | 11.44 | 22 | 195114 | 22267 | 64281329 |
Cholestasis | 20.76 | 11.44 | 68 | 195068 | 44804 | 64258792 |
Pulmonary congestion | 20.72 | 11.44 | 25 | 195111 | 23855 | 64279741 |
Hypophosphatasia | 20.72 | 11.44 | 7 | 195129 | 38 | 64303558 |
Degenerative bone disease | 20.57 | 11.44 | 7 | 195129 | 39 | 64303557 |
Tricuspid valve incompetence | 20.56 | 11.44 | 13 | 195123 | 16990 | 64286606 |
Lichen planus | 20.52 | 11.44 | 30 | 195106 | 2298 | 64301298 |
Creatinine renal clearance decreased | 20.43 | 11.44 | 9 | 195127 | 14412 | 64289184 |
Atrioventricular block complete | 20.42 | 11.44 | 9 | 195127 | 14409 | 64289187 |
Acetabulum fracture | 20.40 | 11.44 | 15 | 195121 | 505 | 64303091 |
Parkinsonism | 20.31 | 11.44 | 9 | 195127 | 14364 | 64289232 |
Traumatic fracture | 20.31 | 11.44 | 18 | 195118 | 794 | 64302802 |
Hepatomegaly | 20.29 | 11.44 | 13 | 195123 | 16869 | 64286727 |
Pollakiuria | 20.27 | 11.44 | 164 | 194972 | 31366 | 64272230 |
Anaphylactic shock | 20.26 | 11.44 | 38 | 195098 | 30290 | 64273306 |
Hair disorder | 20.16 | 11.44 | 19 | 195117 | 908 | 64302688 |
Neutrophil count increased | 20.15 | 11.44 | 28 | 195108 | 25146 | 64278450 |
Drug level decreased | 20.10 | 11.44 | 5 | 195131 | 11498 | 64292098 |
Rash maculo-papular | 19.91 | 11.44 | 74 | 195062 | 46952 | 64256644 |
Metastases to neck | 19.86 | 11.44 | 6 | 195130 | 21 | 64303575 |
Prostate cancer recurrent | 19.60 | 11.44 | 17 | 195119 | 728 | 64302868 |
Scab | 19.57 | 11.44 | 66 | 195070 | 8956 | 64294640 |
Caesarean section | 19.51 | 11.44 | 5 | 195131 | 11269 | 64292327 |
Catheter site injury | 19.37 | 11.44 | 9 | 195127 | 124 | 64303472 |
Oliguria | 19.26 | 11.44 | 10 | 195126 | 14566 | 64289030 |
Productive cough | 19.17 | 11.44 | 136 | 195000 | 73067 | 64230529 |
Lung infiltration | 19.07 | 11.44 | 21 | 195115 | 20868 | 64282728 |
Medial tibial stress syndrome | 18.99 | 11.44 | 9 | 195127 | 130 | 64303466 |
Triple negative breast cancer | 18.98 | 11.44 | 8 | 195128 | 86 | 64303510 |
Mitral valve incompetence | 18.89 | 11.44 | 30 | 195106 | 25508 | 64278088 |
Coordination abnormal | 18.71 | 11.44 | 11 | 195125 | 14953 | 64288643 |
Bradyphrenia | 18.71 | 11.44 | 3 | 195133 | 9403 | 64294193 |
Oligodipsia | 18.50 | 11.44 | 6 | 195130 | 28 | 64303568 |
Bone marrow oedema | 18.46 | 11.44 | 20 | 195116 | 1130 | 64302466 |
Cholecystitis chronic | 18.39 | 11.44 | 3 | 195133 | 9284 | 64294312 |
Cardiomegaly | 18.31 | 11.44 | 27 | 195109 | 23657 | 64279939 |
Epilepsy | 18.29 | 11.44 | 47 | 195089 | 33484 | 64270112 |
Electrocardiogram QRS complex prolonged | 18.27 | 11.44 | 3 | 195133 | 9241 | 64294355 |
Pain of skin | 18.26 | 11.44 | 67 | 195069 | 9480 | 64294116 |
Oral disorder | 18.25 | 11.44 | 64 | 195072 | 8857 | 64294739 |
Atrial flutter | 18.23 | 11.44 | 19 | 195117 | 19361 | 64284235 |
Macule | 18.19 | 11.44 | 29 | 195107 | 2397 | 64301199 |
Product administration error | 18.15 | 11.44 | 35 | 195101 | 27608 | 64275988 |
Vision blurred | 18.13 | 11.44 | 180 | 194956 | 90136 | 64213460 |
Myelodysplastic syndrome | 18.04 | 11.44 | 35 | 195101 | 27544 | 64276052 |
Hyperammonaemia | 17.91 | 11.44 | 4 | 195132 | 9900 | 64293696 |
Prostatic specific antigen decreased | 17.90 | 11.44 | 7 | 195129 | 61 | 64303535 |
Vertebral lesion | 17.85 | 11.44 | 13 | 195123 | 431 | 64303165 |
Respiratory acidosis | 17.78 | 11.44 | 4 | 195132 | 9851 | 64293745 |
Carcinoembryonic antigen increased | 17.78 | 11.44 | 25 | 195111 | 1848 | 64301748 |
Nail disorder | 17.76 | 11.44 | 62 | 195074 | 8562 | 64295034 |
Irritable bowel syndrome | 17.72 | 11.44 | 56 | 195080 | 37313 | 64266283 |
Blood pressure systolic increased | 17.72 | 11.44 | 83 | 195053 | 49370 | 64254226 |
Aspiration | 17.71 | 11.44 | 15 | 195121 | 16870 | 64286726 |
Toxic encephalopathy | 17.68 | 11.44 | 4 | 195132 | 9811 | 64293785 |
Osteosclerosis | 17.53 | 11.44 | 35 | 195101 | 3451 | 64300145 |
Hypotonia | 17.53 | 11.44 | 6 | 195130 | 11206 | 64292390 |
Thyroid operation | 17.53 | 11.44 | 9 | 195127 | 156 | 64303440 |
Duodenal ulcer | 17.51 | 11.44 | 11 | 195125 | 14424 | 64289172 |
Metastases to bladder | 17.31 | 11.44 | 10 | 195126 | 221 | 64303375 |
Therapeutic product effect incomplete | 17.30 | 11.44 | 215 | 194921 | 103267 | 64200329 |
Blood glucose decreased | 17.26 | 11.44 | 27 | 195109 | 23096 | 64280500 |
Cough | 17.20 | 11.44 | 743 | 194393 | 301405 | 64002191 |
Chemotherapy | 17.19 | 11.44 | 22 | 195114 | 1485 | 64302111 |
Diffuse large B-cell lymphoma | 17.17 | 11.44 | 5 | 195131 | 10356 | 64293240 |
Macroenzyme creatine kinase | 17.13 | 11.44 | 5 | 195131 | 15 | 64303581 |
Failure to anastomose | 17.11 | 11.44 | 10 | 195126 | 226 | 64303370 |
Extraskeletal ossification | 17.05 | 11.44 | 7 | 195129 | 70 | 64303526 |
CYP3A4 polymorphism | 17.05 | 11.44 | 7 | 195129 | 70 | 64303526 |
Myopathy | 17.01 | 11.44 | 17 | 195119 | 17663 | 64285933 |
Troponin increased | 17.00 | 11.44 | 13 | 195123 | 15386 | 64288210 |
Breath sounds abnormal | 16.98 | 11.44 | 7 | 195129 | 11662 | 64291934 |
Metastases to soft tissue | 16.96 | 11.44 | 12 | 195124 | 380 | 64303216 |
Speech disorder | 16.95 | 11.44 | 82 | 195054 | 48359 | 64255237 |
Clavicle fracture | 16.92 | 11.44 | 36 | 195100 | 3713 | 64299883 |
Oral mucosal erythema | 16.92 | 11.44 | 23 | 195113 | 1646 | 64301950 |
Sleep apnoea syndrome | 16.91 | 11.44 | 41 | 195095 | 29791 | 64273805 |
Colitis | 16.87 | 11.44 | 106 | 195030 | 58568 | 64245028 |
Bone scan abnormal | 16.84 | 11.44 | 9 | 195127 | 170 | 64303426 |
Blood creatinine abnormal | 16.78 | 11.44 | 38 | 195098 | 4089 | 64299507 |
Erysipelas | 16.76 | 11.44 | 63 | 195073 | 9018 | 64294578 |
Fibula fracture | 16.74 | 11.44 | 32 | 195104 | 3056 | 64300540 |
Onychalgia | 16.69 | 11.44 | 16 | 195120 | 781 | 64302815 |
Dental cyst | 16.66 | 11.44 | 5 | 195131 | 17 | 64303579 |
Vertebral wedging | 16.66 | 11.44 | 5 | 195131 | 17 | 64303579 |
Body temperature increased | 16.66 | 11.44 | 56 | 195080 | 36610 | 64266986 |
Acute generalised exanthematous pustulosis | 16.66 | 11.44 | 11 | 195125 | 14047 | 64289549 |
Hyperbilirubinaemia | 16.56 | 11.44 | 24 | 195112 | 21181 | 64282415 |
Drug eruption | 16.55 | 11.44 | 55 | 195081 | 36081 | 64267515 |
Facial pain | 16.47 | 11.44 | 57 | 195079 | 7838 | 64295758 |
Splenomegaly | 16.46 | 11.44 | 18 | 195118 | 17943 | 64285653 |
Hypercalcaemic nephropathy | 16.45 | 11.44 | 4 | 195132 | 4 | 64303592 |
Diverticulitis | 16.41 | 11.44 | 184 | 194952 | 38434 | 64265162 |
Patella fracture | 16.39 | 11.44 | 22 | 195114 | 1556 | 64302040 |
Allergy to plants | 16.33 | 11.44 | 14 | 195122 | 590 | 64303006 |
Skin haemorrhage | 16.21 | 11.44 | 60 | 195076 | 8525 | 64295071 |
Erectile dysfunction | 16.19 | 11.44 | 9 | 195127 | 12618 | 64290978 |
Brain injury | 16.17 | 11.44 | 5 | 195131 | 9960 | 64293636 |
Lipase increased | 16.10 | 11.44 | 12 | 195124 | 14390 | 64289206 |
Ileus | 16.04 | 11.44 | 28 | 195108 | 22938 | 64280658 |
Palpitations | 16.03 | 11.44 | 221 | 194915 | 104267 | 64199329 |
Parathyroid gland operation | 16.03 | 11.44 | 5 | 195131 | 20 | 64303576 |
Epistaxis | 15.99 | 11.44 | 205 | 194931 | 97926 | 64205670 |
Metastases to peritoneum | 15.94 | 11.44 | 34 | 195102 | 3513 | 64300083 |
Hypercalciuria | 15.89 | 11.44 | 12 | 195124 | 421 | 64303175 |
VIth nerve paresis | 15.82 | 11.44 | 8 | 195128 | 134 | 64303462 |
Device malfunction | 15.79 | 11.44 | 18 | 195118 | 17615 | 64285981 |
Gingival discolouration | 15.74 | 11.44 | 9 | 195127 | 195 | 64303401 |
Electrolyte imbalance | 15.69 | 11.44 | 33 | 195103 | 25210 | 64278386 |
Spinal disorder | 15.68 | 11.44 | 60 | 195076 | 8662 | 64294934 |
Cardiac failure chronic | 15.66 | 11.44 | 4 | 195132 | 9037 | 64294559 |
Migraine | 15.66 | 11.44 | 118 | 195018 | 62559 | 64241037 |
Wrong technique in product usage process | 15.64 | 11.44 | 280 | 194856 | 64694 | 64238902 |
Platelet count decreased | 15.61 | 11.44 | 387 | 194749 | 167324 | 64136272 |
Ventricular extrasystoles | 15.59 | 11.44 | 18 | 195118 | 17511 | 64286085 |
Chronic leukaemia | 15.57 | 11.44 | 4 | 195132 | 6 | 64303590 |
Chromaturia | 15.40 | 11.44 | 28 | 195108 | 22583 | 64281013 |
Rotator cuff syndrome | 15.38 | 11.44 | 75 | 195061 | 12032 | 64291564 |
Euthanasia | 15.37 | 11.44 | 6 | 195130 | 52 | 64303544 |
Blood pressure abnormal | 15.28 | 11.44 | 85 | 195051 | 14350 | 64289246 |
Colitis ulcerative | 15.26 | 11.44 | 29 | 195107 | 22999 | 64280597 |
Hepatic function abnormal | 15.18 | 11.44 | 123 | 195013 | 64190 | 64239406 |
Sputum discoloured | 15.17 | 11.44 | 19 | 195117 | 17837 | 64285759 |
Lip exfoliation | 15.17 | 11.44 | 13 | 195123 | 548 | 64303048 |
Blood pressure systolic decreased | 15.09 | 11.44 | 4 | 195132 | 8816 | 64294780 |
Immune thrombocytopenia | 15.06 | 11.44 | 14 | 195122 | 15052 | 64288544 |
Wisdom teeth removal | 15.02 | 11.44 | 11 | 195125 | 368 | 64303228 |
Treatment noncompliance | 14.99 | 11.44 | 74 | 195062 | 43408 | 64260188 |
Clostridium difficile colitis | 14.97 | 11.44 | 38 | 195098 | 27185 | 64276411 |
Generalised oedema | 14.95 | 11.44 | 25 | 195111 | 20828 | 64282768 |
Burning sensation | 14.93 | 11.44 | 222 | 194914 | 49442 | 64254154 |
Polyneuropathy in malignant disease | 14.92 | 11.44 | 8 | 195128 | 152 | 64303444 |
Injection site haemorrhage | 14.87 | 11.44 | 32 | 195104 | 24246 | 64279350 |
Blood pressure diastolic decreased | 14.85 | 11.44 | 28 | 195108 | 22273 | 64281323 |
Hypocalcaemic seizure | 14.82 | 11.44 | 5 | 195131 | 27 | 64303569 |
Skin sensitisation | 14.78 | 11.44 | 15 | 195121 | 785 | 64302811 |
Sense of oppression | 14.76 | 11.44 | 20 | 195116 | 1427 | 64302169 |
Skin necrosis | 14.70 | 11.44 | 13 | 195123 | 14316 | 64289280 |
Skin disorder | 14.68 | 11.44 | 138 | 194998 | 27542 | 64276054 |
Encephalitis | 14.68 | 11.44 | 10 | 195126 | 12561 | 64291035 |
Pulmonary embolism | 14.65 | 11.44 | 334 | 194802 | 146022 | 64157574 |
Fear | 14.63 | 11.44 | 24 | 195112 | 20147 | 64283449 |
Blood culture positive | 14.59 | 11.44 | 3 | 195133 | 7865 | 64295731 |
Cholecystitis | 14.59 | 11.44 | 23 | 195113 | 19613 | 64283983 |
Mental disorder | 14.48 | 11.44 | 37 | 195099 | 26408 | 64277188 |
Febrile bone marrow aplasia | 14.47 | 11.44 | 8 | 195128 | 11247 | 64292349 |
Electrocardiogram QT prolonged | 14.46 | 11.44 | 162 | 194974 | 79286 | 64224310 |
Pleural neoplasm | 14.42 | 11.44 | 9 | 195127 | 230 | 64303366 |
Macular degeneration | 14.41 | 11.44 | 44 | 195092 | 5666 | 64297930 |
Diabetic endorgan damage | 14.41 | 11.44 | 3 | 195133 | 0 | 64303596 |
Injection site movement impairment | 14.41 | 11.44 | 3 | 195133 | 0 | 64303596 |
Periodontal operation | 14.41 | 11.44 | 3 | 195133 | 0 | 64303596 |
Bone metabolism biochemical marker increased | 14.41 | 11.44 | 3 | 195133 | 0 | 64303596 |
Serum procollagen type I N-terminal propeptide decreased | 14.41 | 11.44 | 3 | 195133 | 0 | 64303596 |
Tuberculosis | 14.40 | 11.44 | 11 | 195125 | 13027 | 64290569 |
Therapy interrupted | 14.38 | 11.44 | 24 | 195112 | 20012 | 64283584 |
Intramedullary rod insertion | 14.30 | 11.44 | 8 | 195128 | 166 | 64303430 |
Fistula | 14.27 | 11.44 | 63 | 195073 | 9698 | 64293898 |
Eosinophil count increased | 14.24 | 11.44 | 13 | 195123 | 14099 | 64289497 |
Hepatic necrosis | 14.21 | 11.44 | 4 | 195132 | 8469 | 64295127 |
Malocclusion | 13.97 | 11.44 | 7 | 195129 | 115 | 64303481 |
Lip and/or oral cavity cancer | 13.96 | 11.44 | 12 | 195124 | 508 | 64303088 |
Immobile | 13.94 | 11.44 | 45 | 195091 | 5970 | 64297626 |
Catatonia | 13.94 | 11.44 | 3 | 195133 | 7617 | 64295979 |
Ear disorder | 13.87 | 11.44 | 30 | 195106 | 3130 | 64300466 |
Dermatitis exfoliative | 13.83 | 11.44 | 7 | 195129 | 10345 | 64293251 |
Upper respiratory tract infection | 13.81 | 11.44 | 147 | 194989 | 72638 | 64230958 |
Bone cancer metastatic | 13.80 | 11.44 | 8 | 195128 | 178 | 64303418 |
Platelet count increased | 13.79 | 11.44 | 22 | 195114 | 18674 | 64284922 |
Gait inability | 13.77 | 11.44 | 192 | 194944 | 42176 | 64261420 |
Neurotoxicity | 13.76 | 11.44 | 40 | 195096 | 27364 | 64276232 |
Arteriosclerosis coronary artery | 13.75 | 11.44 | 16 | 195120 | 15513 | 64288083 |
Vulvovaginal rash | 13.73 | 11.44 | 6 | 195130 | 71 | 64303525 |
Mucosal pain | 13.71 | 11.44 | 4 | 195132 | 12 | 64303584 |
Hypovolaemic shock | 13.63 | 11.44 | 7 | 195129 | 10259 | 64293337 |
Malpositioned teeth | 13.61 | 11.44 | 5 | 195131 | 36 | 64303560 |
Mood altered | 13.58 | 11.44 | 17 | 195119 | 15962 | 64287634 |
Gastritis erosive | 13.57 | 11.44 | 6 | 195130 | 9589 | 64294007 |
International normalised ratio decreased | 13.56 | 11.44 | 3 | 195133 | 7475 | 64296121 |
Vascular fragility | 13.55 | 11.44 | 7 | 195129 | 123 | 64303473 |
Polyuria | 13.54 | 11.44 | 11 | 195125 | 12632 | 64290964 |
Bacterial sepsis | 13.51 | 11.44 | 3 | 195133 | 7454 | 64296142 |
Vipoma | 13.47 | 11.44 | 4 | 195132 | 13 | 64303583 |
Ventricular arrhythmia | 13.40 | 11.44 | 3 | 195133 | 7412 | 64296184 |
Pruritus | 13.36 | 11.44 | 1108 | 194028 | 311292 | 63992304 |
Visual acuity reduced | 13.35 | 11.44 | 40 | 195096 | 27101 | 64276495 |
Motor dysfunction | 13.34 | 11.44 | 9 | 195127 | 11364 | 64292232 |
Tumour lysis syndrome | 13.31 | 11.44 | 24 | 195112 | 19416 | 64284180 |
Urine abnormality | 13.26 | 11.44 | 3 | 195133 | 7359 | 64296237 |
Brachiocephalic vein thrombosis | 13.25 | 11.44 | 7 | 195129 | 129 | 64303467 |
Hypertension | 13.24 | 11.44 | 645 | 194491 | 258616 | 64044980 |
Skin exfoliation | 13.24 | 11.44 | 200 | 194936 | 44685 | 64258911 |
Conjunctivitis | 13.17 | 11.44 | 26 | 195110 | 20328 | 64283268 |
Fracture pain | 13.16 | 11.44 | 10 | 195126 | 354 | 64303242 |
Hip arthroplasty | 13.16 | 11.44 | 110 | 195026 | 21241 | 64282355 |
Hypoaesthesia teeth | 13.15 | 11.44 | 5 | 195131 | 40 | 64303556 |
Chronic kidney disease | 13.11 | 11.44 | 112 | 195024 | 57807 | 64245789 |
Post procedural haemorrhage | 13.09 | 11.44 | 11 | 195125 | 12420 | 64291176 |
Spinal fusion surgery | 13.09 | 11.44 | 32 | 195104 | 3619 | 64299977 |
Injection site bruising | 13.06 | 11.44 | 61 | 195075 | 36312 | 64267284 |
Tenosynovitis | 13.05 | 11.44 | 10 | 195126 | 11823 | 64291773 |
Lymphocyte count decreased | 13.05 | 11.44 | 71 | 195065 | 40628 | 64262968 |
Injected limb mobility decreased | 13.03 | 11.44 | 4 | 195132 | 15 | 64303581 |
Extradural neoplasm | 13.03 | 11.44 | 4 | 195132 | 15 | 64303581 |
Electrocardiogram ST segment elevation | 12.99 | 11.44 | 3 | 195133 | 7256 | 64296340 |
Blood phosphorus abnormal | 12.97 | 11.44 | 9 | 195127 | 276 | 64303320 |
Jaundice cholestatic | 12.94 | 11.44 | 5 | 195131 | 8665 | 64294931 |
Electrocardiogram abnormal | 12.92 | 11.44 | 13 | 195123 | 13468 | 64290128 |
Tachyphylaxis | 12.91 | 11.44 | 9 | 195127 | 278 | 64303318 |
Blister | 12.87 | 11.44 | 170 | 194966 | 80797 | 64222799 |
Atrophic vulvovaginitis | 12.87 | 11.44 | 17 | 195119 | 1184 | 64302412 |
Pulmonary tumour thrombotic microangiopathy | 12.83 | 11.44 | 6 | 195130 | 84 | 64303512 |
Bladder disorder | 12.81 | 11.44 | 52 | 195084 | 7715 | 64295881 |
Ocular hyperaemia | 12.80 | 11.44 | 31 | 195105 | 22533 | 64281063 |
Cerebral haematoma | 12.80 | 11.44 | 3 | 195133 | 7182 | 64296414 |
Injection site swelling | 12.79 | 11.44 | 73 | 195063 | 41280 | 64262316 |
Blood lactate dehydrogenase increased | 12.77 | 11.44 | 54 | 195082 | 33024 | 64270572 |
Periprosthetic fracture | 12.72 | 11.44 | 12 | 195124 | 574 | 64303022 |
Hypoxic-ischaemic encephalopathy | 12.71 | 11.44 | 3 | 195133 | 7149 | 64296447 |
Aplastic anaemia | 12.70 | 11.44 | 14 | 195122 | 13906 | 64289690 |
Acute pulmonary oedema | 12.69 | 11.44 | 12 | 195124 | 12797 | 64290799 |
Pulmonary fibrosis | 12.66 | 11.44 | 47 | 195089 | 29831 | 64273765 |
Giant cell arteritis | 12.65 | 11.44 | 24 | 195112 | 2279 | 64301317 |
Carbohydrate antigen 27.29 increased | 12.64 | 11.44 | 5 | 195131 | 45 | 64303551 |
Metastases to vagina | 12.63 | 11.44 | 4 | 195132 | 17 | 64303579 |
Osteoporosis postmenopausal | 12.63 | 11.44 | 4 | 195132 | 17 | 64303579 |
Faeces discoloured | 12.60 | 11.44 | 38 | 195098 | 25691 | 64277905 |
Urine output decreased | 12.55 | 11.44 | 19 | 195117 | 16473 | 64287123 |
Lymphopenia | 12.49 | 11.44 | 38 | 195098 | 25619 | 64277977 |
Blood 1,25-dihydroxycholecalciferol increased | 12.45 | 11.44 | 4 | 195132 | 18 | 64303578 |
Breast disorder | 12.45 | 11.44 | 20 | 195116 | 1664 | 64301932 |
Colonoscopy | 12.44 | 11.44 | 20 | 195116 | 1665 | 64301931 |
Gastroenteritis | 12.42 | 11.44 | 47 | 195089 | 29664 | 64273932 |
Staphylococcal bacteraemia | 12.41 | 11.44 | 8 | 195128 | 10347 | 64293249 |
Peripheral swelling | 12.38 | 11.44 | 512 | 194624 | 208641 | 64094955 |
Arteriosclerosis | 12.37 | 11.44 | 18 | 195118 | 15859 | 64287737 |
Osteomalacia | 12.37 | 11.44 | 18 | 195118 | 1373 | 64302223 |
Eastern Cooperative Oncology Group performance status worsened | 12.36 | 11.44 | 17 | 195119 | 1231 | 64302365 |
Dental paraesthesia | 12.34 | 11.44 | 3 | 195133 | 3 | 64303593 |
Retinal operation | 12.34 | 11.44 | 3 | 195133 | 3 | 64303593 |
Enteritis | 12.34 | 11.44 | 11 | 195125 | 12066 | 64291530 |
Oestradiol abnormal | 12.28 | 11.44 | 4 | 195132 | 19 | 64303577 |
Ammonia increased | 12.26 | 11.44 | 3 | 195133 | 6974 | 64296622 |
Carpal tunnel decompression | 12.24 | 11.44 | 11 | 195125 | 494 | 64303102 |
Leukoencephalopathy | 12.23 | 11.44 | 3 | 195133 | 6964 | 64296632 |
Atrioventricular block | 12.20 | 11.44 | 11 | 195125 | 12004 | 64291592 |
Affect lability | 12.13 | 11.44 | 6 | 195130 | 8984 | 64294612 |
Knee arthroplasty | 12.10 | 11.44 | 130 | 195006 | 26869 | 64276727 |
Bronchitis | 12.09 | 11.44 | 244 | 194892 | 108499 | 64195097 |
Vertigo | 12.05 | 11.44 | 248 | 194888 | 58763 | 64244833 |
Oesophagitis | 12.05 | 11.44 | 30 | 195106 | 21600 | 64281996 |
Hyperuricaemia | 12.04 | 11.44 | 8 | 195128 | 10183 | 64293413 |
Metastatic neoplasm | 11.94 | 11.44 | 35 | 195101 | 4407 | 64299189 |
Atrioventricular block first degree | 11.93 | 11.44 | 9 | 195127 | 10725 | 64292871 |
Nail avulsion | 11.90 | 11.44 | 6 | 195130 | 100 | 64303496 |
Demyelination | 11.89 | 11.44 | 3 | 195133 | 6831 | 64296765 |
Cementoplasty | 11.88 | 11.44 | 3 | 195133 | 4 | 64303592 |
Gingival cyst | 11.88 | 11.44 | 3 | 195133 | 4 | 64303592 |
Bone operation | 11.86 | 11.44 | 8 | 195128 | 234 | 64303362 |
Rash erythematous | 11.85 | 11.44 | 210 | 194926 | 48423 | 64255173 |
Sternal fracture | 11.83 | 11.44 | 23 | 195113 | 2224 | 64301372 |
Ecchymosis | 11.83 | 11.44 | 15 | 195121 | 14007 | 64289589 |
Surgery | 11.80 | 11.44 | 134 | 195002 | 28079 | 64275517 |
Hypercalcaemia of malignancy | 11.79 | 11.44 | 9 | 195127 | 321 | 64303275 |
Pericardial effusion | 11.76 | 11.44 | 70 | 195066 | 39184 | 64264412 |
Cholelithiasis | 11.69 | 11.44 | 85 | 195051 | 45421 | 64258175 |
Liver function test increased | 11.68 | 11.44 | 51 | 195085 | 30919 | 64272677 |
Cataract | 11.67 | 11.44 | 219 | 194917 | 51043 | 64252553 |
Spondylolisthesis | 11.67 | 11.44 | 26 | 195110 | 2768 | 64300828 |
Breast cancer female | 11.67 | 11.44 | 38 | 195098 | 5065 | 64298531 |
Bone density increased | 11.66 | 11.44 | 11 | 195125 | 526 | 64303070 |
Granuloma annulare | 11.65 | 11.44 | 11 | 195125 | 527 | 64303069 |
Clostridium difficile infection | 11.64 | 11.44 | 63 | 195073 | 36100 | 64267496 |
Hepatotoxicity | 11.59 | 11.44 | 72 | 195064 | 39890 | 64263706 |
Blood potassium increased | 11.58 | 11.44 | 40 | 195096 | 25940 | 64277656 |
Coronary artery occlusion | 11.57 | 11.44 | 15 | 195121 | 13876 | 64289720 |
Abdominal pain upper | 11.55 | 11.44 | 423 | 194713 | 174607 | 64128989 |
Neoplasm | 11.53 | 11.44 | 47 | 195089 | 6984 | 64296612 |
Enterococcal infection | 11.53 | 11.44 | 15 | 195121 | 13851 | 64289745 |
Invasive lobular breast carcinoma | 11.53 | 11.44 | 11 | 195125 | 534 | 64303062 |
Urethritis noninfective | 11.50 | 11.44 | 4 | 195132 | 24 | 64303572 |
None
Source | Code | Description |
---|---|---|
ATC | M05BX04 | MUSCULO-SKELETAL SYSTEM DRUGS FOR TREATMENT OF BONE DISEASES DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION Other drugs affecting bone structure and mineralization |
MeSH PA | D050071 | Bone Density Conservation Agents |
FDA MoA | N0000187054 | RANK Ligand Blocking Activity |
FDA EPC | N0000187055 | RANK Ligand Inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Drug-induced osteoporosis | indication | 14651005 | |
Osteoporosis | indication | 64859006 | DOID:11476 |
Postmenopausal osteoporosis | indication | 102447009 |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Tumor necrosis factor ligand superfamily member 11 | Cytokine | ANTIBODY BINDING | DRUG LABEL | DRUG LABEL |
ID | Source |
---|---|
D03684 | KEGG_DRUG |
4030131 | VUID |
N0000181718 | NUI |
4030131 | VANDF |
CHEMBL1237023 | ChEMBL_ID |
6886 | IUPHAR_LIGAND_ID |
8653 | INN_ID |
DB06643 | DRUGBANK_ID |
4EQZ6YO2HI | UNII |
993449 | RXNORM |
173191 | MMSL |
27218 | MMSL |
d07640 | MMSL |
446321003 | SNOMEDCT_US |
446457007 | SNOMEDCT_US |
D000069448 | MESH_DESCRIPTOR_UI |
C1690432 | UMLSCUI |
013441 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Prolia | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-710 | INJECTION | 60 mg | SUBCUTANEOUS | BLA | 34 sections |
Prolia | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-710 | INJECTION | 60 mg | SUBCUTANEOUS | BLA | 34 sections |
XGEVA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-730 | INJECTION | 120 mg | SUBCUTANEOUS | BLA | 29 sections |