denosumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
human origin 4965 615258-40-7

Description:

MoleculeDescription

Synonyms:

  • denosumab
  • prolia
  • AMG 162
  • AMG162
A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.33 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 26, 2010 EMA Amgen Europe B.V.
June 1, 2010 FDA AMGEN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 44255.26 11.30 27558 192774 646904 62621786
Osteonecrosis of jaw 11079.95 11.30 4271 216061 30852 63237838
Death 5901.30 11.30 6846 213486 367535 62901155
Spinal fracture 2579.15 11.30 1262 219070 17009 63251681
Bone pain 2079.58 11.30 1634 218698 53007 63215683
Hypocalcaemia 1917.46 11.30 1257 219075 30456 63238234
Tooth disorder 1825.14 11.30 1166 219166 26991 63241699
Atypical femur fracture 1519.68 11.30 605 219727 4767 63263923
Pain in jaw 1472.48 11.30 1215 219117 42281 63226409
Drug ineffective 1379.74 11.30 980 219352 1043785 62224905
Tooth extraction 1362.01 11.30 680 219652 9584 63259106
Back pain 1223.28 11.30 2775 217557 261370 63007320
Pain in extremity 1052.19 11.30 3019 217313 328467 62940223
Myalgia 1002.89 11.30 1812 218520 144717 63123973
Occupational exposure to product 893.50 11.30 318 220014 1760 63266930
Accidental exposure to product 866.07 11.30 736 219596 26669 63242021
Bone density abnormal 848.72 11.30 350 219982 3048 63265642
Fracture 832.62 11.30 626 219706 18958 63249732
Thoracic vertebral fracture 750.55 11.30 351 219981 4241 63264449
Bone density decreased 739.29 11.30 519 219813 14093 63254597
Tooth fracture 734.28 11.30 466 219866 10644 63258046
Rebound effect 678.62 11.30 326 220006 4200 63264490
Metastases to bone 667.17 11.30 566 219766 20453 63248237
Lumbar vertebral fracture 646.59 11.30 342 219990 5468 63263222
Maternal exposure during pregnancy 622.01 11.30 35 220297 220027 63048663
Toothache 617.60 11.30 521 219811 18678 63250012
Pemphigus 591.16 11.30 9 220323 183717 63084973
Arthralgia 586.29 11.30 3674 216658 566036 62702654
Spinal compression fracture 579.39 11.30 444 219888 13839 63254851
Toxicity to various agents 557.52 11.30 94 220238 247156 63021534
Femur fracture 552.83 11.30 703 219629 41053 63227637
Infusion related reaction 545.58 11.30 97 220235 245424 63023266
Drug intolerance 538.95 11.30 199 220133 308462 62960228
Blood parathyroid hormone increased 536.39 11.30 245 220087 2793 63265897
Hip fracture 530.99 11.30 581 219751 28893 63239797
Synovitis 524.28 11.30 31 220301 186887 63081803
Dental implantation 519.89 11.30 164 220168 578 63268112
Dental care 515.41 11.30 179 220153 910 63267780
Contraindicated product administered 512.81 11.30 73 220259 217575 63051115
Exposure during pregnancy 512.05 11.30 5 220327 155542 63113148
Exposed bone in jaw 507.36 11.30 233 220099 2692 63265998
Jaw disorder 501.25 11.30 281 220051 5068 63263622
Systemic lupus erythematosus 492.36 11.30 70 220262 208848 63059842
Tooth loss 489.36 11.30 302 220030 6554 63262136
Groin pain 480.61 11.30 347 219985 9856 63258834
Treatment failure 477.79 11.30 63 220269 198980 63069710
Completed suicide 473.51 11.30 6 220326 145667 63123023
Pathological fracture 470.80 11.30 324 220008 8510 63260180
Condition aggravated 441.91 11.30 447 219885 401770 62866920
Product storage error 440.65 11.30 386 219946 14570 63254120
Product use issue 433.29 11.30 115 220217 220405 63048285
Glossodynia 412.06 11.30 64 220268 178812 63089878
Bone loss 398.36 11.30 201 220131 2898 63265792
Breast cancer metastatic 390.34 11.30 328 220004 11690 63257000
Hand deformity 383.75 11.30 50 220282 159407 63109283
Therapeutic product effect decreased 377.11 11.30 102 220230 193085 63075605
Joint swelling 366.76 11.30 358 219974 327308 62941382
Drug hypersensitivity 363.55 11.30 326 220006 310361 62958329
Terminal state 356.22 11.30 169 220163 2113 63266577
Exostosis of jaw 346.61 11.30 140 220192 1149 63267541
Loose tooth 344.64 11.30 188 220144 3206 63265484
Hepatic enzyme increased 342.00 11.30 137 220195 202191 63066499
Pericarditis 334.72 11.30 34 220298 131545 63137145
Musculoskeletal pain 330.51 11.30 880 219452 91397 63177293
Drug interaction 329.74 11.30 193 220139 228938 63039752
Metastases to liver 327.15 11.30 407 219925 23232 63245458
Wound 317.10 11.30 87 220245 163176 63105514
Abdominal discomfort 309.33 11.30 396 219936 320489 62948201
Helicobacter infection 284.66 11.30 8 220324 92777 63175913
Product use in unapproved indication 283.97 11.30 133 220199 178947 63089743
Dental caries 281.61 11.30 260 220072 10519 63258171
Neoplasm progression 277.81 11.30 473 219859 35955 63232735
Osteomyelitis 272.54 11.30 391 219941 25629 63243061
Blood calcium decreased 271.98 11.30 394 219938 26057 63242633
Rheumatoid factor positive 271.94 11.30 4 220328 84402 63184288
Duodenal ulcer perforation 269.48 11.30 7 220325 87202 63181488
Acute kidney injury 266.51 11.30 313 220019 263102 63005588
Swelling 265.16 11.30 340 219992 275038 62993652
Atypical fracture 260.88 11.30 94 220238 542 63268148
Hypotension 251.83 11.30 347 219985 272257 62996433
Hospitalisation 251.46 11.30 757 219575 84324 63184366
Foot fracture 251.42 11.30 360 219972 23554 63245136
Incorrect route of product administration 245.34 11.30 383 219949 27069 63241621
Intentional overdose 241.13 11.30 3 220329 74149 63194541
Intercepted product administration error 239.58 11.30 78 220254 312 63268378
Confusional state 235.74 11.30 284 220048 236096 63032594
Overdose 235.60 11.30 55 220277 115023 63153667
Drug abuse 235.52 11.30 3 220329 72515 63196175
Vomiting 235.40 11.30 1071 219261 558546 62710144
Compression fracture 232.45 11.30 187 220145 6261 63262429
Malignant neoplasm progression 223.49 11.30 710 219622 81411 63187279
Blood calcium increased 220.31 11.30 213 220119 9137 63259553
Bone disorder 219.74 11.30 318 220014 21008 63247682
Investigation 214.83 11.30 107 220225 1498 63267192
Endodontic procedure 210.59 11.30 134 220198 3073 63265617
Osteonecrosis 207.84 11.30 334 219998 24196 63244494
Intentional product use issue 207.34 11.30 92 220240 127800 63140890
Rheumatoid arthritis 205.70 11.30 353 219979 253466 63015224
Folliculitis 205.45 11.30 9 220323 70308 63198382
Psoriatic arthropathy 201.24 11.30 37 220295 91483 63177207
Somnolence 194.19 11.30 200 220132 178485 63090205
Multiple fractures 189.41 11.30 189 220143 8429 63260261
Weight increased 188.18 11.30 389 219943 260403 63008287
Hypersensitivity 188.11 11.30 465 219867 292220 62976470
Jaw operation 186.80 11.30 80 220252 772 63267918
Muscle injury 185.67 11.30 10 220322 65335 63203355
Dyspnoea 181.77 11.30 1448 218884 659865 62608825
Wrist fracture 181.71 11.30 230 220102 13357 63255333
Eczema 178.22 11.30 365 219967 31926 63236764
Muscle spasms 175.23 11.30 1032 219300 155118 63113572
Gingival disorder 174.92 11.30 124 220208 3418 63265272
Pelvic fracture 173.85 11.30 223 220109 13125 63255565
Tooth abscess 170.21 11.30 234 220098 14735 63253955
Temporomandibular joint syndrome 167.75 11.30 128 220204 3961 63264729
Blood calcium abnormal 165.20 11.30 83 220249 1185 63267505
Suicide attempt 165.07 11.30 12 220320 60906 63207784
Arthropathy 161.22 11.30 360 219972 234432 63034258
Tooth infection 155.93 11.30 247 220085 17673 63251017
Gingival pain 155.90 11.30 166 220166 7996 63260694
Headache 155.79 11.30 1427 218905 631814 62636876
Sinusitis 153.60 11.30 350 219982 226303 63042387
Fall 152.35 11.30 2052 218280 390282 62878408
Dental operation 152.33 11.30 80 220252 1259 63267431
Metastases to lung 152.08 11.30 204 220128 12546 63256144
Breast cancer 151.95 11.30 440 219892 47943 63220747
Spinal pain 150.31 11.30 206 220126 12933 63255757
Discomfort 148.53 11.30 219 220113 167155 63101535
Stress fracture 146.90 11.30 159 220173 7804 63260886
Artificial crown procedure 146.80 11.30 52 220280 283 63268407
Lower respiratory tract infection 146.10 11.30 146 220186 132161 63136529
Liver injury 145.46 11.30 19 220313 60501 63208189
Bradycardia 142.14 11.30 39 220293 73188 63195502
Seizure 141.21 11.30 151 220181 132483 63136207
Gingivitis 141.17 11.30 160 220172 8269 63260421
Pyrexia 140.46 11.30 1006 219326 469472 62799218
Gingival recession 139.98 11.30 78 220254 1389 63267301
Cystitis 138.36 11.30 463 219869 54528 63214162
Bedridden 138.26 11.30 181 220151 10870 63257820
Type 2 diabetes mellitus 137.89 11.30 27 220305 63841 63204849
Hyperaesthesia teeth 134.63 11.30 82 220250 1736 63266954
Irritable bowel syndrome 133.99 11.30 59 220273 82353 63186337
Cardiac arrest 132.91 11.30 78 220254 92467 63176223
Tetany 132.36 11.30 84 220248 1917 63266773
Nausea 132.19 11.30 2130 218202 852341 62416349
Gingival swelling 132.08 11.30 115 220217 4303 63264387
Rib fracture 131.33 11.30 261 220071 22336 63246354
Abscess jaw 129.58 11.30 73 220259 1329 63267361
Tumour marker increased 129.25 11.30 119 220213 4796 63263894
Abdominal pain 128.83 11.30 552 219780 292904 62975786
Abortion spontaneous 128.73 11.30 9 220323 47186 63221504
Osteonecrosis of external auditory canal 127.36 11.30 37 220295 90 63268600
Pneumonia 126.65 11.30 997 219335 455770 62812920
Depressed level of consciousness 126.37 11.30 30 220302 62048 63206642
Tachycardia 126.35 11.30 134 220198 118022 63150668
Coma 125.45 11.30 34 220298 64330 63204360
C-reactive protein abnormal 125.12 11.30 9 220323 46087 63222603
Wheezing 124.47 11.30 90 220242 95505 63173185
Suicidal ideation 123.51 11.30 32 220300 62389 63206301
Osteitis 122.39 11.30 97 220235 3177 63265513
Periodontitis 121.63 11.30 97 220235 3206 63265484
Mobility decreased 121.51 11.30 778 219554 120381 63148309
Lactic acidosis 114.90 11.30 4 220328 38283 63230407
Dental restoration failure 112.37 11.30 59 220273 928 63267762
Cardio-respiratory arrest 110.76 11.30 35 220297 59924 63208766
Infection 110.06 11.30 416 219916 228757 63039933
Body height decreased 107.81 11.30 153 220179 9925 63258765
Osteoporotic fracture 106.96 11.30 95 220237 3651 63265039
Carbohydrate antigen 15-3 increased 106.43 11.30 65 220267 1383 63267307
Multiple sclerosis relapse 105.70 11.30 20 220312 48458 63220232
C-telopeptide increased 104.40 11.30 24 220308 9 63268681
Metastases to lymph nodes 104.21 11.30 135 220197 8023 63260667
Metastases to spine 104.10 11.30 88 220244 3161 63265529
Febrile neutropenia 102.14 11.30 158 220174 118291 63150399
Musculoskeletal discomfort 101.39 11.30 205 220127 17762 63250928
Oxygen saturation decreased 100.96 11.30 95 220237 88490 63180200
Blister 99.24 11.30 187 220145 129627 63139063
Hypercalcaemia 99.18 11.30 268 220064 28054 63240636
Hyponatraemia 98.67 11.30 147 220185 111753 63156937
Mastication disorder 97.75 11.30 71 220261 2035 63266655
Influenza like illness 97.61 11.30 475 219857 66349 63202341
Dermatitis 97.50 11.30 195 220137 16763 63251927
Upper limb fracture 96.03 11.30 207 220125 18761 63249929
Musculoskeletal stiffness 96.02 11.30 324 220008 184294 63084396
Vitamin D decreased 95.85 11.30 146 220186 10096 63258594
Agitation 93.69 11.30 45 220287 59712 63208978
Sequestrectomy 92.97 11.30 49 220283 777 63267913
Inappropriate schedule of product administration 92.44 11.30 648 219684 103317 63165373
Nasopharyngitis 88.77 11.30 518 219814 253739 63014951
Anaphylactic reaction 87.66 11.30 61 220271 66039 63202651
Dental cleaning 87.50 11.30 22 220310 22 63268668
PIK3CA-activated mutation 86.82 11.30 51 220281 1008 63267682
Prescribed overdose 86.35 11.30 9 220323 34144 63234546
Serotonin syndrome 86.05 11.30 3 220329 28679 63240011
International normalised ratio increased 85.93 11.30 27 220305 46398 63222292
Rash pruritic 85.86 11.30 423 219909 59376 63209314
Lower limb fracture 85.62 11.30 230 220102 23991 63244699
Metabolic acidosis 85.61 11.30 25 220307 45044 63223646
Asthma 85.51 11.30 198 220134 127363 63141327
Oedema 85.33 11.30 129 220203 97493 63171197
Unresponsive to stimuli 85.27 11.30 9 220323 33807 63234883
Hyperparathyroidism 85.10 11.30 73 220259 2676 63266014
Neoplasm malignant 84.70 11.30 262 220070 29599 63239091
Hypoglycaemia 84.31 11.30 52 220280 60013 63208677
Respiratory failure 83.92 11.30 140 220192 101718 63166972
Peripheral swelling 82.44 11.30 562 219770 265380 63003310
No adverse event 82.34 11.30 21 220311 41384 63227306
Anxiety 82.04 11.30 432 219900 217109 63051581
Metastases to central nervous system 81.79 11.30 156 220176 12949 63255741
Injury 80.63 11.30 81 220251 73166 63195524
Encephalopathy 79.92 11.30 18 220314 38602 63230088
Hypoxia 79.53 11.30 55 220277 59737 63208953
Fractured sacrum 78.10 11.30 61 220271 1955 63266735
Femoral neck fracture 77.65 11.30 120 220212 8403 63260287
Intentional self-injury 75.99 11.30 3 220329 25684 63243006
Migraine 75.41 11.30 153 220179 103193 63165497
Foetal exposure during pregnancy 74.52 11.30 11 220321 31951 63236739
Respiratory arrest 74.37 11.30 12 220320 32633 63236057
Premature delivery 73.99 11.30 9 220323 30272 63238418
Tooth erosion 73.74 11.30 35 220297 438 63268252
Immobile 72.27 11.30 96 220236 5847 63262843
Dental necrosis 71.99 11.30 25 220307 127 63268563
Multiple organ dysfunction syndrome 71.84 11.30 55 220277 56697 63211993
Joint noise 71.23 11.30 82 220250 4310 63264380
Chest discomfort 71.07 11.30 174 220158 109795 63158895
Dry skin 70.99 11.30 387 219945 56500 63212190
Incorrect dose administered 69.88 11.30 63 220269 59905 63208785
Gingival abscess 69.68 11.30 41 220291 813 63267877
Syncope 69.55 11.30 194 220138 117191 63151499
Dehydration 68.89 11.30 338 219994 173016 63095674
Hypophosphataemia 67.63 11.30 133 220199 11293 63257397
Psoriasis 66.68 11.30 125 220207 86832 63181858
Chest pain 66.59 11.30 457 219875 215502 63053188
Delirium 66.54 11.30 47 220285 50494 63218196
Gastrointestinal haemorrhage 66.47 11.30 112 220220 81064 63187626
Jaw fistula 66.35 11.30 19 220313 43 63268647
Oral pain 66.10 11.30 233 220099 28161 63240529
Blood pressure decreased 65.91 11.30 77 220255 64945 63203745
Blood parathyroid hormone abnormal 65.15 11.30 26 220306 206 63268484
C-reactive protein increased 65.09 11.30 145 220187 94562 63174128
Tooth resorption 63.39 11.30 18 220314 39 63268651
Product quality issue 62.65 11.30 23 220309 35842 63232848
Vitamin D abnormal 62.24 11.30 23 220309 144 63268546
Therapeutic response decreased 62.21 11.30 73 220259 61452 63207238
Drug withdrawal syndrome 61.94 11.30 10 220322 27184 63241506
Mental status changes 61.79 11.30 30 220302 39569 63229121
Pulpitis dental 61.49 11.30 39 220293 889 63267801
Loss of consciousness 60.90 11.30 208 220124 117913 63150777
Circumstance or information capable of leading to medication error 60.66 11.30 71 220261 3799 63264891
Sedation 59.66 11.30 30 220302 38779 63229911
Metastases to skin 59.45 11.30 48 220284 1615 63267075
Red blood cell sedimentation rate increased 59.10 11.30 40 220292 43942 63224748
Blood phosphorus decreased 58.94 11.30 75 220257 4378 63264312
Spinal deformity 58.66 11.30 40 220292 1034 63267656
Toxic epidermal necrolysis 58.42 11.30 9 220323 25325 63243365
Sleep disorder due to general medical condition, insomnia type 58.32 11.30 57 220275 52160 63216530
Humerus fracture 57.96 11.30 108 220224 8808 63259882
Alanine aminotransferase increased 57.48 11.30 177 220155 103593 63165097
Drug level increased 57.46 11.30 6 220326 22730 63245960
Psychotic disorder 57.36 11.30 10 220322 25702 63242988
Injection site erythema 55.81 11.30 129 220203 83045 63185645
Traumatic fracture 55.48 11.30 33 220299 668 63268022
Hallucination 55.47 11.30 65 220267 54752 63213938
Tibia fracture 55.16 11.30 78 220254 5042 63263648
Hyperkalaemia 55.14 11.30 64 220268 54139 63214551
Sinus tachycardia 55.11 11.30 9 220323 24259 63244431
Living in residential institution 55.07 11.30 30 220302 510 63268180
Emotional distress 54.99 11.30 22 220310 32527 63236163
Flushing 54.91 11.30 111 220221 74976 63193714
Muscle spasticity 54.44 11.30 6 220326 21788 63246902
Heart rate decreased 54.12 11.30 47 220285 45513 63223177
Hospice care 53.98 11.30 98 220234 7834 63260856
Wrong technique in product usage process 53.89 11.30 386 219946 61954 63206736
Drug reaction with eosinophilia and systemic symptoms 53.77 11.30 25 220307 33811 63234879
Mouth swelling 53.74 11.30 74 220258 4666 63264024
Prescribed underdose 53.65 11.30 18 220314 29671 63239019
Oedema peripheral 53.60 11.30 411 219921 189100 63079590
Dental fistula 52.94 11.30 31 220301 609 63268081
Jaw fracture 52.85 11.30 55 220277 2579 63266111
Radius fracture 52.56 11.30 64 220268 3571 63265119
Musculoskeletal chest pain 52.56 11.30 177 220155 20906 63247784
Parathyroidectomy 52.13 11.30 23 220309 240 63268450
Parathyroid disorder 52.01 11.30 31 220301 630 63268060
Blood pressure increased 51.92 11.30 339 219993 161723 63106967
Neck pain 51.39 11.30 414 219918 68904 63199786
Obesity 51.00 11.30 20 220312 29932 63238758
Dysarthria 50.81 11.30 44 220288 42667 63226023
Injection site reaction 50.49 11.30 78 220254 58446 63210244
Polymyalgia rheumatica 50.41 11.30 64 220268 3727 63264963
Rhabdomyolysis 50.22 11.30 47 220285 43904 63224786
Depression 50.15 11.30 438 219894 196054 63072636
Drug ineffective for unapproved indication 49.90 11.30 28 220304 34035 63234655
Hand fracture 49.70 11.30 78 220254 5535 63263155
Dental discomfort 49.61 11.30 27 220305 458 63268232
Sleep disorder due to a general medical condition 49.55 11.30 122 220210 12066 63256624
Diarrhoea 49.52 11.30 2006 218326 713360 62555330
Aspartate aminotransferase increased 49.28 11.30 155 220177 90122 63178568
Septic shock 49.14 11.30 98 220234 66531 63202159
Dizziness 49.12 11.30 1127 219205 428798 62839892
Pancytopenia 49.08 11.30 172 220160 96761 63171929
Adverse reaction 48.98 11.30 109 220223 10094 63258596
Tremor 48.48 11.30 265 220067 131974 63136716
Orthostatic hypotension 48.43 11.30 33 220299 36127 63232563
Osteoporosis 48.39 11.30 353 219979 56985 63211705
Fluid retention 48.26 11.30 83 220249 59603 63209087
Scoliosis 48.12 11.30 93 220239 7795 63260895
Blood alkaline phosphatase decreased 47.85 11.30 37 220295 1168 63267522
Medication error 47.73 11.30 67 220265 52217 63216473
Rheumatoid nodule 47.58 11.30 3 220329 17152 63251538
Cognitive disorder 47.57 11.30 75 220257 55740 63212950
Hyperparathyroidism secondary 47.55 11.30 40 220292 1427 63267263
Haematochezia 47.51 11.30 70 220262 53474 63215216
Generalised tonic-clonic seizure 46.79 11.30 21 220311 28995 63239695
Dental prosthesis placement 46.27 11.30 15 220317 59 63268631
Sepsis 46.21 11.30 326 220006 152797 63115893
Vitamin D deficiency 46.19 11.30 129 220203 13763 63254927
Parathyroid tumour 45.84 11.30 18 220314 136 63268554
Product dose omission issue 45.70 11.30 1100 219232 233213 63035477
Periodontal disease 45.48 11.30 41 220291 1607 63267083
Fatigue 45.30 11.30 2572 217760 885456 62383234
Cardiac failure congestive 44.82 11.30 167 220165 92266 63176424
Hypophosphatasia 44.79 11.30 11 220321 9 63268681
Fibromyalgia 44.65 11.30 137 220195 80283 63188407
Device failure 44.43 11.30 77 220255 5934 63262756
Metastasis 44.34 11.30 71 220261 5126 63263564
Nasal congestion 43.92 11.30 102 220230 65558 63203132
Menopausal symptoms 43.41 11.30 48 220284 2413 63266277
Heart rate increased 43.30 11.30 174 220158 94064 63174626
Oral surgery 42.81 11.30 35 220297 1199 63267491
Abdominal pain upper 42.73 11.30 484 219848 205960 63062730
Drug-induced liver injury 42.54 11.30 46 220286 40176 63228514
Eosinophilia 42.53 11.30 13 220319 22743 63245947
Renal failure 42.45 11.30 237 220095 117415 63151275
Device dislocation 42.41 11.30 18 220314 25687 63243003
Noninfective gingivitis 42.05 11.30 37 220295 1404 63267286
Stevens-Johnson syndrome 41.92 11.30 17 220315 24933 63243757
Liver function test abnormal 41.77 11.30 64 220268 48117 63220573
Bone lesion 41.73 11.30 74 220258 5807 63262883
Gait disturbance 41.36 11.30 878 219454 182300 63086390
Hyperhidrosis 41.25 11.30 213 220119 107623 63161067
Oral infection 41.19 11.30 67 220265 4901 63263789
Pulmonary arterial hypertension 40.25 11.30 14 220318 22563 63246127
Right ventricular failure 39.88 11.30 6 220326 17182 63251508
Caesarean section 39.39 11.30 6 220326 17026 63251664
Drug dependence 39.04 11.30 18 220314 24465 63244225
Paraesthesia 38.94 11.30 763 219569 156203 63112487
Abdominal lymphadenopathy 38.93 11.30 27 220305 718 63267972
Status epilepticus 38.54 11.30 4 220328 15229 63253461
Parathyroid tumour malignant 38.38 11.30 11 220321 25 63268665
Bronchitis 38.17 11.30 265 220067 124670 63144020
Unevaluable event 38.13 11.30 307 220025 51079 63217611
Hypervolaemia 37.96 11.30 26 220306 28387 63240303
Product prescribing error 37.95 11.30 22 220310 26267 63242423
Oestrogen deficiency 37.95 11.30 16 220316 148 63268542
Ulna fracture 37.94 11.30 32 220300 1146 63267544
Bone resorption test abnormal 37.43 11.30 9 220323 6 63268684
Trismus 37.23 11.30 56 220276 3829 63264861
Injection site pruritus 37.16 11.30 62 220270 45054 63223636
Bone graft 36.79 11.30 29 220303 942 63267748
Staphylococcal infection 36.54 11.30 54 220278 41202 63227488
Aggression 36.36 11.30 18 220314 23480 63245210
Pulmonary fibrosis 36.35 11.30 51 220281 39758 63228932
Ventricular tachycardia 36.29 11.30 12 220320 19967 63248723
Pleural neoplasm 36.15 11.30 20 220312 351 63268339
Spinal operation 35.99 11.30 85 220247 8186 63260504
Contusion 35.86 11.30 340 219992 149704 63118986
Disease recurrence 35.68 11.30 27 220305 28003 63240687
Dyskinesia 35.66 11.30 35 220297 31967 63236723
Cytokine release syndrome 35.60 11.30 4 220328 14310 63254380
Injury associated with device 35.35 11.30 53 220279 3613 63265077
Metastases to pleura 35.27 11.30 35 220297 1550 63267140
Hypertension 35.07 11.30 721 219611 278582 62990108
Drug dose omission by device 34.83 11.30 61 220271 4740 63263950
Forearm fracture 34.74 11.30 22 220310 500 63268190
Immune system disorder 34.37 11.30 93 220239 9741 63258949
Tubulointerstitial nephritis 34.37 11.30 13 220319 19890 63248800
Amnesia 34.31 11.30 90 220242 55495 63213195
Cytomegalovirus infection 34.04 11.30 15 220317 20937 63247753
Product substitution issue 34.02 11.30 7 220325 15989 63252701
Blood glucose increased 34.00 11.30 162 220170 83594 63185096
Poisoning 33.65 11.30 4 220328 13696 63254994
Acute respiratory distress syndrome 33.54 11.30 20 220312 23514 63245176
Lichen planus 33.54 11.30 41 220291 2297 63266393
Haematemesis 33.04 11.30 34 220298 30378 63238312
Intentional product misuse 32.95 11.30 105 220227 60812 63207878
Cyanosis 32.89 11.30 9 220323 16926 63251764
White blood cell count increased 32.83 11.30 75 220257 48486 63220204
Neutropenia 32.72 11.30 817 219515 174188 63094502
Infusion site pain 32.70 11.30 9 220323 16860 63251830
Labelled drug-drug interaction medication error 32.69 11.30 4 220328 13395 63255295
Blood pressure fluctuation 32.57 11.30 70 220262 46247 63222443
Haematoma 32.40 11.30 44 220288 34776 63233914
Oral cavity fistula 32.04 11.30 23 220309 647 63268043
Obstructive airways disorder 31.81 11.30 16 220316 20683 63248007
Irritability 31.62 11.30 38 220294 31656 63237034
Hemiparesis 31.51 11.30 21 220311 23261 63245429
Withdrawal syndrome 31.43 11.30 15 220317 19982 63248708
Cholesteatoma 31.41 11.30 14 220318 150 63268540
Therapeutic product effect incomplete 31.34 11.30 280 220052 124776 63143914
Photophobia 31.33 11.30 11 220321 17624 63251066
Osteolysis 31.28 11.30 44 220288 2830 63265860
Feeling abnormal 31.17 11.30 704 219628 147688 63121002
COVID-19 31.16 11.30 247 220085 112856 63155834
Lymphoedema 30.78 11.30 100 220232 11592 63257098
Circulatory collapse 30.77 11.30 19 220313 21919 63246771
Metastases to peritoneum 30.71 11.30 48 220284 3394 63265296
Dementia 30.66 11.30 138 220194 18656 63250034
Mydriasis 30.62 11.30 3 220329 11953 63256737
Tachypnoea 30.38 11.30 11 220321 17291 63251399
Bronchospasm 30.32 11.30 11 220321 17269 63251421
Denture wearer 30.18 11.30 15 220317 209 63268481
Oral discomfort 30.16 11.30 85 220247 9116 63259574
Inflammation 30.07 11.30 165 220167 82108 63186582
Extrapyramidal disorder 30.00 11.30 5 220327 13279 63255411
Coagulopathy 29.93 11.30 17 220315 20527 63248163
Paranoia 29.72 11.30 3 220329 11676 63257014
Back disorder 29.71 11.30 95 220237 10922 63257768
Pulmonary hypertension 29.67 11.30 52 220280 37071 63231619
Respiratory distress 29.52 11.30 45 220287 33906 63234784
Patella fracture 29.49 11.30 37 220295 2129 63266561
Gastrointestinal disorder 29.43 11.30 302 220030 130937 63137753
Angioedema 29.35 11.30 78 220254 47887 63220803
Nightmare 29.26 11.30 15 220317 19179 63249511
Gingival operation 29.04 11.30 12 220320 105 63268585
Accidental overdose 28.97 11.30 23 220309 23286 63245404
Respiratory rate increased 28.97 11.30 6 220326 13642 63255048
Intercepted medication error 28.94 11.30 21 220311 601 63268089
Blood creatine phosphokinase increased 28.77 11.30 38 220294 30392 63238298
Facet joint syndrome 28.71 11.30 4 220328 12134 63256556
White blood cell count decreased 28.61 11.30 658 219674 138446 63130244
Hallucination, auditory 28.58 11.30 5 220327 12819 63255871
Palpitations 28.47 11.30 252 220080 112518 63156172
Therapy non-responder 28.42 11.30 151 220181 75750 63192940
Acute myeloid leukaemia 28.30 11.30 12 220320 17135 63251555
Onychoclasis 28.23 11.30 65 220267 6157 63262533
Chemotherapy 28.20 11.30 31 220301 1548 63267142
Bone giant cell tumour malignant 28.00 11.30 6 220326 0 63268690
Deep vein thrombosis 27.99 11.30 173 220159 83627 63185063
Pneumonia aspiration 27.95 11.30 48 220284 34492 63234198
Haemoglobin decreased 27.82 11.30 347 219985 145138 63123552
Kyphosis 27.82 11.30 39 220293 2501 63266189
Anuria 27.74 11.30 5 220327 12546 63256144
Gingival erythema 27.72 11.30 22 220310 722 63267968
Scab 27.72 11.30 74 220258 7689 63261001
Ill-defined disorder 27.72 11.30 168 220164 81587 63187103
Rash papular 27.67 11.30 118 220214 15584 63253106
Creatinine renal clearance decreased 27.58 11.30 11 220321 16297 63252393
Disorientation 27.43 11.30 60 220272 39392 63229298
Metastases to bladder 27.37 11.30 14 220318 208 63268482
Rash macular 27.18 11.30 156 220176 23208 63245482
Body temperature increased 27.17 11.30 55 220277 37137 63231553
Carcinoembryonic antigen increased 27.03 11.30 32 220300 1733 63266957
Pancreatitis 26.92 11.30 84 220248 48971 63219719
Transplant rejection 26.84 11.30 3 220329 10777 63257913
Ankle fracture 26.84 11.30 128 220204 17727 63250963
Abnormal behaviour 26.81 11.30 21 220311 21405 63247285
Wrong product administered 26.60 11.30 63 220269 6078 63262612
Vitamin D increased 26.41 11.30 21 220311 691 63267999
Colitis ulcerative 26.33 11.30 31 220301 26060 63242630
Hypoaesthesia oral 26.19 11.30 102 220230 12931 63255759
Upper respiratory tract infection 26.07 11.30 172 220160 81875 63186815
Acute respiratory failure 26.05 11.30 50 220282 34435 63234255
Sinus bradycardia 25.98 11.30 9 220323 14542 63254148
Ear pain 25.83 11.30 214 220118 35904 63232786
Hungry bone syndrome 25.79 11.30 11 220321 105 63268585
Renal tubular necrosis 25.68 11.30 5 220327 11873 63256817
Affect lability 25.62 11.30 4 220328 11147 63257543
Breast cancer stage III 25.59 11.30 3 220329 10383 63258307
Blood bilirubin increased 25.40 11.30 57 220275 37083 63231607
Oral disorder 25.39 11.30 78 220254 8776 63259914
Respiratory depression 25.33 11.30 8 220324 13707 63254983
Inappropriate antidiuretic hormone secretion 25.23 11.30 11 220321 15451 63253239
General physical health deterioration 25.23 11.30 520 219812 200882 63067808
Bone cancer 25.22 11.30 28 220304 1414 63267276
Abortion induced 25.13 11.30 3 220329 10239 63258451
Disturbance in attention 25.00 11.30 60 220272 38129 63230561
Sciatica 24.89 11.30 204 220128 34120 63234570
Calcinosis 24.76 11.30 34 220298 2138 63266552
Vision blurred 24.74 11.30 202 220130 91722 63176968
Metaphyseal corner fracture 24.57 11.30 8 220324 32 63268658
Diabetic ketoacidosis 24.54 11.30 21 220311 20484 63248206
Coronary artery disease 24.41 11.30 47 220285 32330 63236360
Posterior reversible encephalopathy syndrome 24.36 11.30 15 220317 17330 63251360
Cataract operation 24.30 11.30 57 220275 5465 63263225
Pallor 24.26 11.30 43 220289 30525 63238165
Schizophrenia 24.21 11.30 3 220329 9949 63258741
Rales 24.19 11.30 7 220325 12690 63256000
Nerve compression 24.18 11.30 78 220254 9009 63259681
Grip strength decreased 24.12 11.30 25 220307 22262 63246428
Shock haemorrhagic 24.03 11.30 3 220329 9892 63258798
Cellulitis 24.03 11.30 409 219923 81549 63187141
Gingival cyst 23.86 11.30 6 220326 6 63268684
Breast cancer recurrent 23.86 11.30 49 220283 4292 63264398
Vertebroplasty 23.76 11.30 15 220317 339 63268351
Blood creatinine abnormal 23.71 11.30 40 220292 3016 63265674
Pancreatitis acute 23.63 11.30 36 220296 27130 63241560
Pollakiuria 23.57 11.30 172 220160 27765 63240925
Pulmonary oedema 23.54 11.30 104 220228 54769 63213921
Dental prosthesis user 23.51 11.30 9 220323 63 63268627
Bone marrow failure 23.43 11.30 41 220291 29249 63239441
Drug resistance 23.41 11.30 27 220305 22906 63245784
Altered state of consciousness 23.36 11.30 32 220300 25198 63243492
Orthodontic procedure 23.34 11.30 5 220327 0 63268690
Parathyroid tumour benign 23.32 11.30 20 220312 733 63267957
Cardiogenic shock 23.18 11.30 17 220315 17915 63250775
Haemoptysis 23.17 11.30 40 220292 28686 63240004
Agranulocytosis 23.14 11.30 32 220300 25102 63243588
Hair disorder 23.05 11.30 24 220308 1126 63267564
Bacteraemia 23.01 11.30 16 220316 17332 63251358
Hot flush 22.89 11.30 275 220057 50884 63217806
Therapy interrupted 22.86 11.30 49 220283 32406 63236284
Malpositioned teeth 22.80 11.30 7 220325 22 63268668
Hepatitis 22.64 11.30 67 220265 39721 63228969
Frequent bowel movements 22.54 11.30 28 220304 22994 63245696
Hip surgery 22.47 11.30 41 220291 3290 63265400
Mastectomy 22.40 11.30 28 220304 1605 63267085
Cancer pain 22.32 11.30 40 220292 3165 63265525
Acetabulum fracture 22.31 11.30 14 220318 313 63268377
Rehabilitation therapy 22.17 11.30 28 220304 1622 63267068
Leukocytosis 21.95 11.30 35 220297 25900 63242790
Myoclonus 21.90 11.30 14 220318 15854 63252836
Palliative care 21.89 11.30 17 220315 540 63268150
Dysstasia 21.86 11.30 137 220195 21029 63247661
Haematocrit decreased 21.85 11.30 67 220265 39273 63229417
Amenorrhoea 21.80 11.30 4 220328 9910 63258780
Sputum discoloured 21.78 11.30 15 220317 16332 63252358
Acidosis 21.76 11.30 6 220326 11227 63257463
Hyperthermia 21.70 11.30 3 220329 9153 63259537
Akathisia 21.67 11.30 3 220329 9143 63259547
Hypothermia 21.63 11.30 10 220322 13571 63255119
Gingival ulceration 21.56 11.30 21 220311 909 63267781
Ataxia 21.53 11.30 13 220319 15182 63253508
Muscle tightness 21.41 11.30 90 220242 11810 63256880
Clavicle fracture 21.40 11.30 41 220291 3414 63265276
Bone sequestrum 21.39 11.30 26 220306 1448 63267242
Deformity 21.26 11.30 7 220325 11677 63257013
Hypokalaemia 21.21 11.30 244 220088 103560 63165130
Bone density increased 21.20 11.30 19 220313 739 63267951
Blood 1,25-dihydroxycholecalciferol increased 21.00 11.30 5 220327 3 63268687
Dental paraesthesia 21.00 11.30 5 220327 3 63268687
Serum procollagen type I N-terminal propeptide decreased 21.00 11.30 5 220327 3 63268687
Musculoskeletal disorder 20.93 11.30 133 220199 20511 63248179
Basal cell carcinoma 20.78 11.30 41 220291 27950 63240740
Paraesthesia oral 20.74 11.30 126 220206 19130 63249560
Adrenal insufficiency 20.65 11.30 19 220313 17896 63250794
Coordination abnormal 20.64 11.30 11 220321 13762 63254928
Pneumocystis jirovecii pneumonia 20.64 11.30 17 220315 16897 63251793
Macule 20.54 11.30 30 220302 1998 63266692
Delusion 20.50 11.30 8 220324 12009 63256681
Lupus-like syndrome 20.43 11.30 14 220318 15281 63253409
Panniculitis 20.40 11.30 7 220325 11378 63257312
Acute coronary syndrome 20.39 11.30 5 220327 10121 63258569
Restlessness 20.30 11.30 45 220287 29408 63239282
Cholelithiasis 20.23 11.30 81 220251 43844 63224846
Ventricular fibrillation 20.08 11.30 8 220324 11859 63256831
Triple negative breast cancer 20.08 11.30 10 220322 140 63268550
Myelosuppression 20.05 11.30 32 220300 23671 63245019
Alopecia 20.04 11.30 962 219370 336574 62932116
Walking aid user 20.03 11.30 82 220250 10635 63258055
Weight bearing difficulty 20.01 11.30 34 220298 2578 63266112
Diabetes mellitus inadequate control 19.99 11.30 14 220318 15112 63253578
Bone swelling 19.99 11.30 27 220305 1671 63267019
Blood glucose decreased 19.98 11.30 26 220306 20926 63247764
Haemorrhage 19.85 11.30 127 220205 60895 63207795
Illness 19.84 11.30 95 220237 48964 63219726
Atrial fibrillation 19.82 11.30 285 220047 116351 63152339
Abscess oral 19.76 11.30 26 220306 1569 63267121
Oral mucosal erythema 19.76 11.30 26 220306 1569 63267121
Limb discomfort 19.64 11.30 173 220159 29543 63239147
Chronic sinusitis 19.63 11.30 10 220322 12833 63255857
Ankylosing spondylitis 19.54 11.30 6 220326 10468 63258222
Injection site haemorrhage 19.48 11.30 34 220298 24280 63244410
Gestational diabetes 19.32 11.30 3 220329 8393 63260297
Injection site swelling 19.31 11.30 92 220240 47480 63221210
Breath sounds abnormal 19.23 11.30 7 220325 10966 63257724
Aphasia 19.19 11.30 55 220277 32945 63235745
Generalised oedema 19.17 11.30 16 220316 15802 63252888
Atelectasis 19.14 11.30 28 220304 21455 63247235
Peri-implantitis 19.07 11.30 8 220324 73 63268617
Bone erosion 19.03 11.30 20 220312 17697 63250993
Oral neoplasm benign 18.98 11.30 5 220327 7 63268683
Impaired healing 18.94 11.30 478 219854 102064 63166626
Injection site bruising 18.85 11.30 78 220254 41832 63226858
Decreased immune responsiveness 18.81 11.30 48 220284 4853 63263837
Metastases to meninges 18.80 11.30 33 220299 2569 63266121
Hepatocellular injury 18.74 11.30 42 220290 27339 63241351
VIth nerve paresis 18.70 11.30 8 220324 77 63268613
Thyroid calcification 18.67 11.30 4 220328 0 63268690
Shock 18.63 11.30 33 220299 23430 63245260
Vaccination site reaction 18.46 11.30 9 220323 120 63268570
CYP3A4 polymorphism 18.43 11.30 8 220324 80 63268610
Aspergillus infection 18.38 11.30 3 220329 8090 63260600
Renal injury 18.36 11.30 5 220327 9434 63259256
Skin necrosis 18.32 11.30 13 220319 13937 63254753
Eye irritation 18.27 11.30 30 220302 21941 63246749
Gingival injury 18.24 11.30 6 220326 25 63268665
Metastases to spinal cord 18.20 11.30 9 220323 124 63268566
Melaena 18.11 11.30 50 220282 30315 63238375
Sleep apnoea syndrome 18.11 11.30 47 220285 29086 63239604
Panic attack 18.10 11.30 31 220301 22300 63246390
Thrombotic microangiopathy 18.06 11.30 7 220325 10554 63258136
Gastroenteritis 18.02 11.30 41 220291 26549 63242141
Intermenstrual bleeding 17.86 11.30 3 220329 7923 63260767
Tumour marker abnormal 17.85 11.30 13 220319 374 63268316
Enthesopathy 17.85 11.30 4 220328 8610 63260080
Drug level decreased 17.84 11.30 3 220329 7916 63260774
Osteosarcoma 17.82 11.30 9 220323 130 63268560
Osteocalcin decreased 17.81 11.30 7 220325 53 63268637
Giant cell arteritis 17.79 11.30 30 220302 2261 63266429
Malocclusion 17.76 11.30 8 220324 88 63268602
Thyroid operation 17.75 11.30 10 220322 182 63268508
Bone deformity 17.58 11.30 15 220317 546 63268144
Vertebral wedging 17.56 11.30 5 220327 11 63268679
Diverticulitis 17.42 11.30 212 220120 39345 63229345
Allergy to plants 17.39 11.30 17 220315 739 63267951
Oliguria 17.37 11.30 5 220327 9096 63259594
Blood creatinine increased 17.36 11.30 208 220124 87636 63181054
Anaemia 17.27 11.30 837 219495 292593 62976097
Intervertebral disc protrusion 17.24 11.30 141 220191 23568 63245122
Metastases to adrenals 17.22 11.30 17 220315 748 63267942
Device malfunction 17.19 11.30 22 220310 17835 63250855
Root canal infection 17.18 11.30 13 220319 397 63268293
Progressive multifocal leukoencephalopathy 17.15 11.30 12 220320 12959 63255731
Mucosal pain 16.98 11.30 5 220327 13 63268677
Breast disorder 16.89 11.30 31 220301 2499 63266191
Ocular hyperaemia 16.86 11.30 39 220293 25105 63243585
Malabsorption 16.81 11.30 41 220291 4031 63264659
Mental disorder 16.74 11.30 41 220291 25878 63242812
Pre-existing condition improved 16.74 11.30 4 220328 8240 63260450
Pseudomonas infection 16.74 11.30 9 220323 11204 63257486
Subarachnoid haemorrhage 16.64 11.30 15 220317 14268 63254422
Lung neoplasm malignant 16.63 11.30 121 220211 19512 63249178
Stress 16.55 11.30 151 220181 67016 63201674
Bone marrow oedema 16.43 11.30 21 220311 1231 63267459
Metastatic neoplasm 16.42 11.30 42 220290 4253 63264437
Upper gastrointestinal haemorrhage 16.38 11.30 25 220307 18827 63249863
Colitis 16.30 11.30 100 220232 48428 63220262
Exostosis 16.25 11.30 112 220220 17750 63250940
Hepatic lesion 16.23 11.30 45 220287 4780 63263910
Angina pectoris 16.15 11.30 52 220280 30026 63238664
Cardiac murmur 16.11 11.30 16 220316 14536 63254154
Infusion site extravasation 16.11 11.30 8 220324 10418 63258272
Blood pressure abnormal 16.09 11.30 99 220233 15099 63253591
Productive cough 16.06 11.30 141 220191 63067 63205623
Dental cyst 16.05 11.30 6 220326 39 63268651
Lip dry 16.02 11.30 18 220314 15452 63253238
Bronchopulmonary aspergillosis 16.02 11.30 5 220327 8630 63260060
Lip exfoliation 15.97 11.30 15 220317 620 63268070
Tartrate-resistant acid phosphatase increased 15.91 11.30 4 220328 4 63268686
Parathyroid hormone-related protein increased 15.91 11.30 4 220328 4 63268686
Hypercalcaemic nephropathy 15.91 11.30 4 220328 4 63268686
Osteosclerosis 15.89 11.30 39 220293 3849 63264841
Metastases to bone marrow 15.81 11.30 13 220319 449 63268241
Gingival discolouration 15.81 11.30 11 220321 294 63268396
Pain of skin 15.77 11.30 81 220251 11553 63257137
Periprosthetic fracture 15.76 11.30 13 220319 451 63268239
Muscle atrophy 15.76 11.30 57 220275 6976 63261714
Osteomalacia 15.75 11.30 16 220316 729 63267961
Hypoaesthesia teeth 15.67 11.30 6 220326 42 63268648
Heart rate irregular 15.67 11.30 34 220298 22387 63246303
Myocardial infarction 15.63 11.30 248 220084 99645 63169045
Spinal disorder 15.62 11.30 72 220260 9830 63258860
Thrombocytopenia 15.62 11.30 402 219930 150755 63117935
Rotator cuff syndrome 15.61 11.30 90 220242 13412 63255278
Tooth discolouration 15.58 11.30 18 220314 950 63267740
Visual impairment 15.54 11.30 203 220129 84243 63184447
Sternal fracture 15.53 11.30 28 220304 2226 63266464
Adjustment disorder with depressed mood 15.51 11.30 8 220324 10196 63258494
Tenosynovitis 15.47 11.30 15 220317 13780 63254910
Mood altered 15.44 11.30 17 220315 14726 63253964
Medial tibial stress syndrome 15.40 11.30 8 220324 123 63268567
Adnexa uteri mass 15.31 11.30 14 220318 559 63268131
Hypovolaemia 15.31 11.30 9 220323 10664 63258026
Psychomotor hyperactivity 15.28 11.30 9 220323 10654 63258036
Acute hepatic failure 15.26 11.30 25 220307 18302 63250388
Infusion site erythema 15.19 11.30 11 220321 11668 63257022
Tricuspid valve incompetence 15.15 11.30 17 220315 14604 63254086
Epilepsy 15.09 11.30 46 220286 27019 63241671
Acute generalised exanthematous pustulosis 15.03 11.30 10 220322 11089 63257601
Encephalitis 15.00 11.30 6 220326 8874 63259816
Acute myocardial infarction 14.95 11.30 59 220273 32065 63236625
Osteochondrosis 14.87 11.30 21 220311 1356 63267334
Eastern Cooperative Oncology Group performance status worsened 14.86 11.30 20 220312 1234 63267456
Bone scan abnormal 14.83 11.30 12 220320 405 63268285
Vertigo 14.80 11.30 291 220041 59596 63209094
Oral pustule 14.77 11.30 6 220326 50 63268640
Carbohydrate antigen 15-3 14.72 11.30 7 220325 88 63268602
Bone infarction 14.71 11.30 11 220321 330 63268360
Activated partial thromboplastin time prolonged 14.69 11.30 3 220329 6890 63261800
Granuloma annulare 14.62 11.30 14 220318 593 63268097
Anger 14.61 11.30 13 220319 12443 63256247
Electrocardiogram QT prolonged 14.60 11.30 134 220198 59396 63209294
Rectal haemorrhage 14.48 11.30 105 220227 48925 63219765
Therapeutic response shortened 14.44 11.30 12 220320 11876 63256814
Cough 14.42 11.30 850 219482 291893 62976797
Tachyphylaxis 14.42 11.30 10 220322 266 63268424
Hepatic function abnormal 14.40 11.30 73 220259 37069 63231621
Brachiocephalic vein thrombosis 14.31 11.30 7 220325 94 63268596
Graft versus host disease 14.30 11.30 3 220329 6760 63261930
Pulmonary tumour thrombotic microangiopathy 14.28 11.30 6 220326 55 63268635
Rash erythematous 14.28 11.30 217 220115 42293 63226397
Hyperglycaemia 14.20 11.30 86 220246 41781 63226909
Inguinal hernia repair 14.18 11.30 6 220326 56 63268634
Diffuse large B-cell lymphoma 14.15 11.30 3 220329 6709 63261981
Urinary tract infection 14.14 11.30 1084 219248 263600 63005090
Ulcer 14.12 11.30 45 220287 26062 63242628
Cardiac failure 14.05 11.30 221 220111 88921 63179769
Febrile bone marrow aplasia 14.03 11.30 4 220328 7321 63261369
C-telopeptide 14.00 11.30 3 220329 0 63268690
Sinus perforation 14.00 11.30 3 220329 0 63268690
Masticatory pain 14.00 11.30 3 220329 0 63268690
Chronic leukaemia 13.98 11.30 4 220328 9 63268681
Vertebral lesion 13.96 11.30 14 220318 628 63268062
Hepatic steatosis 13.92 11.30 52 220280 28717 63239973
Blood urea increased 13.89 11.30 46 220286 26333 63242357
Onychalgia 13.88 11.30 17 220315 954 63267736
Pleural disorder 13.87 11.30 14 220318 633 63268057
Bone metabolism biochemical marker increased 13.85 11.30 5 220327 29 63268661
Myelodysplastic syndrome 13.82 11.30 23 220309 16731 63251959
Drug eruption 13.80 11.30 52 220280 28642 63240048
Device fastener issue 13.74 11.30 7 220325 103 63268587
Toxic encephalopathy 13.74 11.30 3 220329 6576 63262114
Oligodipsia 13.71 11.30 5 220327 30 63268660
Haemodialysis 13.62 11.30 7 220325 8940 63259750
Cervical vertebral fracture 13.62 11.30 29 220303 2605 63266085
Presyncope 13.59 11.30 50 220282 27735 63240955
Liver function test increased 13.58 11.30 63 220269 32748 63235942
Parathyroid gland operation 13.57 11.30 5 220327 31 63268659
Electrolyte imbalance 13.57 11.30 31 220301 20045 63248645
Neoplasm 13.57 11.30 56 220276 7289 63261401
Liver disorder 13.53 11.30 120 220212 53567 63215123
Pulmonary toxicity 13.52 11.30 8 220324 9447 63259243
Speech disorder 13.50 11.30 84 220248 40545 63228145
Hyperlipidaemia 13.49 11.30 115 220217 19456 63249234
Haemorrhage intracranial 13.48 11.30 16 220316 13403 63255287
Subdural haematoma 13.44 11.30 18 220314 14310 63254380
Skin sensitisation 13.42 11.30 16 220316 873 63267817
Carcinoid tumour pulmonary 13.40 11.30 12 220320 466 63268224
Urine calcium increased 13.40 11.30 6 220326 65 63268625
Proteinuria 13.40 11.30 29 220303 19116 63249574
Skin disorder 13.37 11.30 159 220173 29348 63239342
Enteritis 13.35 11.30 6 220326 8280 63260410
Bone fistula 13.32 11.30 6 220326 66 63268624
Eosinophil count increased 13.31 11.30 11 220321 10917 63257773
Dermatitis allergic 13.24 11.30 20 220312 15128 63253562
Apathy 13.21 11.30 7 220325 8787 63259903
Breast pain 13.17 11.30 63 220269 8735 63259955
Injected limb mobility decreased 13.16 11.30 4 220328 12 63268678
Osteosarcoma recurrent 13.16 11.30 4 220328 12 63268678
Hepatotoxicity 13.14 11.30 75 220257 36966 63231724
Urine abnormality 13.13 11.30 4 220328 7015 63261675
Dental plaque 13.12 11.30 7 220325 114 63268576
Platelet count increased 13.10 11.30 26 220306 17685 63251005
Tumour marker decreased 13.09 11.30 6 220326 69 63268621
Sinus congestion 13.07 11.30 27 220305 18096 63250594
Hypercalciuria 13.03 11.30 10 220322 312 63268378
Bradyphrenia 13.02 11.30 4 220328 6976 63261714
Hepatic encephalopathy 12.96 11.30 12 220320 11270 63257420
Female genital tract fistula 12.95 11.30 5 220327 7554 63261136
Fibula fracture 12.89 11.30 34 220298 3508 63265182
Respiratory disorder 12.88 11.30 81 220251 39001 63229689
Injection site urticaria 12.87 11.30 18 220314 14055 63254635
Demyelination 12.85 11.30 4 220328 6916 63261774
Metastases to neck 12.79 11.30 6 220326 73 63268617
Crying 12.79 11.30 40 220292 23303 63245387
Joint destruction 12.76 11.30 3 220329 6249 63262441
Breast cancer stage I 12.76 11.30 4 220328 6885 63261805
Hepatitis cholestatic 12.73 11.30 4 220328 6874 63261816
Blood 25-hydroxycholecalciferol decreased 12.72 11.30 6 220326 74 63268616
Skin exfoliation 12.59 11.30 215 220117 42887 63225803
Central nervous system lesion 12.59 11.30 11 220321 10624 63258066
Bronchiectasis 12.55 11.30 23 220309 16119 63252571
Respiratory tract congestion 12.49 11.30 27 220305 17805 63250885
Vaginal haemorrhage 12.46 11.30 51 220281 27436 63241254
Pulmonary embolism 12.41 11.30 309 220023 116375 63152315
Injection site warmth 12.40 11.30 21 220311 15174 63253516
Catheter site injury 12.39 11.30 9 220323 258 63268432
Nail avulsion 12.36 11.30 8 220324 189 63268501
Pneumonia viral 12.36 11.30 6 220326 7916 63260774
Rhinorrhoea 12.30 11.30 157 220175 65420 63203270
Jaw cyst 12.30 11.30 7 220325 130 63268560
Callus formation delayed 12.29 11.30 4 220328 16 63268674
Blood cholesterol abnormal 12.22 11.30 28 220304 2643 63266047
Clostridium difficile colitis 12.17 11.30 34 220298 20535 63248155
Nasal polyps 12.13 11.30 3 220329 6036 63262654
Metastases to vagina 12.09 11.30 4 220328 17 63268673
Nail growth abnormal 12.06 11.30 12 220320 533 63268157
Aspiration 11.94 11.30 12 220320 10839 63257851
Extradural neoplasm 11.93 11.30 3 220329 3 63268687
Vascular fragility 11.93 11.30 7 220325 138 63268552
Blood pressure systolic increased 11.92 11.30 106 220226 47291 63221399
Pulmonary haemorrhage 11.89 11.30 5 220327 7176 63261514
Polyglandular autoimmune syndrome type II 11.88 11.30 5 220327 46 63268644
Mitral valve incompetence 11.88 11.30 32 220300 19562 63249128
Fungal infection 11.86 11.30 77 220255 36797 63231893
Conjunctivitis 11.85 11.30 35 220297 20761 63247929
Oophorectomy 11.83 11.30 12 220320 546 63268144
Open fracture 11.77 11.30 11 220321 452 63268238
Invasive lobular breast carcinoma 11.73 11.30 15 220317 880 63267810
Mouth ulceration 11.71 11.30 170 220162 32814 63235876
Nail discolouration 11.68 11.30 28 220304 2722 63265968
Metastases to uterus 11.68 11.30 6 220326 90 63268600
Angina unstable 11.65 11.30 5 220327 7090 63261600
Rash maculo-papular 11.63 11.30 64 220268 31832 63236858
Injection site induration 11.60 11.30 9 220323 9217 63259473
Carcinoembryonic antigen 11.56 11.30 6 220326 92 63268598
Gastric disorder 11.53 11.30 79 220253 37290 63231400
Brain injury 11.51 11.30 5 220327 7038 63261652
Bone marrow infiltration 11.48 11.30 13 220319 671 63268019
Respiratory syncytial virus infection 11.44 11.30 5 220327 7013 63261677
Hypercalcaemia of malignancy 11.43 11.30 8 220324 216 63268474
Pharyngitis 11.40 11.30 34 220298 20109 63248581
Tumour flare 11.40 11.30 10 220322 378 63268312
Troponin increased 11.35 11.30 11 220321 10110 63258580
Pathogen resistance 11.35 11.30 4 220328 6394 63262296
Skin irritation 11.30 11.30 65 220267 9676 63259014

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis of jaw 7799.88 14.01 2170 42211 15719 34896831
Off label use 3540.73 14.01 3405 40976 416119 34496431
Hypocalcaemia 1898.09 14.01 817 43564 23472 34889078
Death 1820.65 14.01 2359 42022 395690 34516860
Terminal state 569.40 14.01 207 44174 3727 34908823
Prostatic specific antigen increased 405.36 14.01 245 44136 14435 34898115
Metastases to bone 372.96 14.01 216 44165 11754 34900796
Tooth extraction 303.98 14.01 139 44242 4589 34907961
Tooth disorder 298.79 14.01 181 44200 10701 34901849
Malignant neoplasm progression 274.52 14.01 439 43942 87607 34824943
Bone pain 251.14 14.01 209 44172 20477 34892073
Investigation 245.93 14.01 77 44304 853 34911697
Pain in jaw 238.11 14.01 168 44213 12872 34899678
Atypical femur fracture 222.82 14.01 57 44324 277 34912273
Hospitalisation 207.14 14.01 305 44076 56597 34855953
Prostate cancer metastatic 205.76 14.01 114 44267 5689 34906861
Blood parathyroid hormone increased 205.46 14.01 76 44305 1438 34911112
Blood calcium decreased 188.94 14.01 132 44249 9952 34902598
Hypophosphataemia 173.87 14.01 130 44251 10896 34901654
Exposed bone in jaw 173.40 14.01 68 44313 1518 34911032
Toxicity to various agents 146.58 14.01 37 44344 200325 34712225
Jaw disorder 143.12 14.01 65 44316 2110 34910440
Hypercalcaemia 131.71 14.01 128 44253 15340 34897210
Drug ineffective 127.70 14.01 242 44139 456509 34456041
Osteomyelitis 121.68 14.01 125 44256 16011 34896539
Osteitis 118.55 14.01 52 44329 1552 34910998
Prostate cancer 108.96 14.01 187 44194 39462 34873088
Completed suicide 107.04 14.01 4 44377 98164 34814386
Toothache 106.73 14.01 78 44303 6310 34906240
Occupational exposure to product 103.14 14.01 32 44349 343 34912207
Drug interaction 97.72 14.01 86 44295 225860 34686690
Bone density abnormal 91.32 14.01 22 44359 79 34912471
Dental care 84.80 14.01 26 44355 267 34912283
Pathological fracture 83.45 14.01 58 44323 4333 34908217
Condition aggravated 83.25 14.01 73 44308 192123 34720427
Tooth fracture 82.79 14.01 54 44327 3631 34908919
Spinal fracture 79.22 14.01 70 44311 7428 34905122
Hormone-refractory prostate cancer 78.34 14.01 31 44350 709 34911841
Hot flush 77.74 14.01 105 44276 17961 34894589
Metastases to lung 75.38 14.01 75 44306 9245 34903305
Hypotension 75.24 14.01 103 44278 221546 34691004
Back pain 75.15 14.01 330 44051 121459 34791091
Abscess jaw 70.66 14.01 29 44352 731 34911819
Osteonecrosis 66.30 14.01 88 44293 14802 34897748
Acute kidney injury 65.29 14.01 186 44195 304802 34607748
Cardiac arrest 62.50 14.01 22 44359 96137 34816413
Dental implantation 60.60 14.01 15 44366 62 34912488
Femur fracture 59.55 14.01 62 44319 8062 34904488
Accidental exposure to product 57.52 14.01 76 44305 12726 34899824
Incorrect route of product administration 56.00 14.01 81 44300 14764 34897786
Delusion of grandeur 55.94 14.01 28 44353 1132 34911418
Metastases to lymph nodes 55.75 14.01 47 44334 4681 34907869
Cancer pain 54.81 14.01 37 44344 2635 34909915
Jaw operation 54.23 14.01 17 44364 189 34912361
Blood calcium abnormal 53.92 14.01 22 44359 546 34912004
Metastasis 52.61 14.01 43 44338 4101 34908449
Decreased appetite 52.34 14.01 376 44005 166016 34746534
Dental caries 51.22 14.01 44 44337 4495 34908055
Tooth loss 51.03 14.01 41 44340 3817 34908733
Fracture 49.72 14.01 52 44329 6797 34905753
Tetany 49.08 14.01 23 44358 803 34911747
Impaired healing 48.38 14.01 77 44304 15257 34897293
Thoracic vertebral fracture 48.04 14.01 29 44352 1701 34910849
Fatigue 47.96 14.01 697 43684 369956 34542594
Exostosis of jaw 47.43 14.01 13 44368 86 34912464
Bone fissure 45.42 14.01 10 44371 21 34912529
Endodontic procedure 45.15 14.01 18 44363 420 34912130
Bone density decreased 45.13 14.01 29 44352 1900 34910650
Agitation 43.06 14.01 10 44371 57389 34855161
Bradycardia 42.95 14.01 21 44360 75397 34837153
Blood phosphorus decreased 42.49 14.01 34 44347 3147 34909403
Metastases to liver 42.27 14.01 68 44313 13595 34898955
Tooth abscess 41.70 14.01 44 44337 5809 34906741
Rhinalgia 40.96 14.01 22 44359 1031 34911519
Drug hypersensitivity 40.71 14.01 26 44355 80503 34832047
Jaw fistula 40.66 14.01 10 44371 40 34912510
Hip fracture 40.57 14.01 62 44319 11863 34900687
Gastrointestinal haemorrhage 40.22 14.01 32 44349 88445 34824105
Peri-implantitis 38.90 14.01 12 44369 126 34912424
Metastases to central nervous system 38.86 14.01 50 44331 8155 34904395
Blood calcium increased 38.86 14.01 34 44347 3560 34908990
Loose tooth 36.10 14.01 21 44360 1150 34911400
Artificial crown procedure 35.96 14.01 8 44373 18 34912532
Cardio-respiratory arrest 35.29 14.01 13 44368 55260 34857290
Tachycardia 34.51 14.01 34 44347 84738 34827812
Coma 34.17 14.01 8 44373 45670 34866880
Bone loss 34.10 14.01 16 44365 560 34911990
Bone giant cell tumour malignant 34.02 14.01 6 44375 0 34912550
Neoplasm progression 33.28 14.01 84 44297 23216 34889334
Metastases to spine 33.20 14.01 27 44354 2557 34909993
Gingivitis 33.11 14.01 31 44350 3544 34909006
Chest pain 32.75 14.01 70 44311 126692 34785858
Suicidal ideation 32.43 14.01 6 44375 40382 34872168
Overdose 32.17 14.01 41 44340 91018 34821532
Stress fracture 31.99 14.01 18 44363 925 34911625
Gingival disorder 31.48 14.01 21 44360 1466 34911084
Atypical fracture 31.28 14.01 10 44371 119 34912431
Hungry bone syndrome 30.92 14.01 9 44372 76 34912474
Prostate cancer recurrent 30.79 14.01 18 44363 995 34911555
Periodontitis 30.73 14.01 23 44358 1929 34910621
Lymphocyte count abnormal 30.50 14.01 19 44362 1179 34911371
International normalised ratio increased 30.44 14.01 11 44370 47316 34865234
Disease progression 30.40 14.01 238 44143 107839 34804711
Hyperparathyroidism 30.13 14.01 19 44362 1205 34911345
Failure to anastomose 29.93 14.01 11 44370 204 34912346
Multiple organ dysfunction syndrome 29.70 14.01 32 44349 76534 34836016
Spinal pain 29.66 14.01 37 44344 5852 34906698
Lumbar vertebral fracture 29.22 14.01 24 44357 2305 34910245
Sequestrectomy 28.98 14.01 11 44370 224 34912326
Dental fistula 28.71 14.01 9 44372 100 34912450
Bone disorder 28.08 14.01 37 44344 6178 34906372
Alopecia 27.95 14.01 81 44300 24274 34888276
Abdominal pain 27.90 14.01 110 44271 163508 34749042
Septic shock 27.89 14.01 30 44351 71804 34840746
Hospice care 27.84 14.01 39 44342 6901 34905649
Carbohydrate antigen 15-3 increased 27.23 14.01 8 44373 70 34912480
Respiratory failure 27.18 14.01 61 44320 108511 34804039
Aggression 26.91 14.01 8 44373 38956 34873594
Mastication disorder 26.25 14.01 18 44363 1315 34911235
Bone lesion 26.12 14.01 25 44356 2938 34909612
Bone formation increased 26.01 14.01 5 44376 3 34912547
Palliative care 25.12 14.01 14 44367 706 34911844
Polyneuropathy in malignant disease 25.02 14.01 10 44371 235 34912315
Psoriasis 24.99 14.01 9 44372 38803 34873747
Pleurocutaneous fistula 24.84 14.01 7 44374 52 34912498
Febrile neutropenia 24.62 14.01 90 44291 136759 34775791
Affective disorder 24.57 14.01 29 44352 4331 34908219
Product storage error 24.55 14.01 40 44341 8082 34904468
Weight increased 24.33 14.01 51 44330 92982 34819568
Spinal compression fracture 24.21 14.01 37 44344 7079 34905471
Gingival abscess 24.05 14.01 9 44372 176 34912374
Confusional state 23.89 14.01 98 44283 144062 34768488
Nephrocalcinosis 23.71 14.01 13 44368 635 34911915
Product use in unapproved indication 23.36 14.01 74 44307 117425 34795125
Drug effective for unapproved indication 23.02 14.01 22 44359 2580 34909970
Wheezing 22.86 14.01 12 44369 41390 34871160
Pseudarthrosis 22.65 14.01 7 44374 74 34912476
Asthma 22.63 14.01 13 44368 42643 34869907
Gingival swelling 22.45 14.01 16 44365 1244 34911306
Metastases to soft tissue 22.44 14.01 11 44370 425 34912125
Cough 21.91 14.01 107 44274 150033 34762517
Respiratory distress 21.75 14.01 9 44372 35656 34876894
Parathyroid tumour malignant 21.44 14.01 5 44376 15 34912535
Tooth infection 21.35 14.01 34 44347 6737 34905813
Blood bilirubin increased 21.29 14.01 11 44370 38285 34874265
Treatment failure 21.07 14.01 17 44364 46680 34865870
Hypoglycaemia 21.00 14.01 23 44358 54617 34857933
Macroenzyme creatine kinase 20.97 14.01 5 44376 17 34912533
Suture rupture 20.90 14.01 10 44371 366 34912184
Myocardial infarction 20.89 14.01 81 44300 121004 34791546
Depression 20.85 14.01 59 44322 97039 34815511
Eosinophilia 20.83 14.01 4 44377 26218 34886332
Arthralgia 20.78 14.01 317 44064 169724 34742826
Pyrexia 20.73 14.01 298 44083 332715 34579835
Pericoronitis 20.45 14.01 4 44377 3 34912547
Anxiety 20.20 14.01 62 44319 99366 34813184
Jaw fracture 20.16 14.01 14 44367 1044 34911506
Coronary artery disease 20.08 14.01 19 44362 48286 34864264
Prostatic specific antigen abnormal 19.84 14.01 12 44369 706 34911844
Dental restoration failure 19.77 14.01 5 44376 23 34912527
Metabolic acidosis 19.59 14.01 16 44365 43664 34868886
Abnormal behaviour 19.43 14.01 4 44377 24965 34887585
Limbic encephalitis 19.34 14.01 10 44371 433 34912117
Bone fistula 19.26 14.01 5 44376 26 34912524
Angioedema 18.97 14.01 12 44369 37362 34875188
Alanine aminotransferase increased 18.94 14.01 47 44334 80768 34831782
Respiratory arrest 18.93 14.01 6 44375 28037 34884513
Chest discomfort 18.79 14.01 25 44356 54505 34858045
Haematemesis 18.58 14.01 6 44375 27705 34884845
Hyperaesthesia 18.54 14.01 26 44355 4604 34907946
Hallucination 18.37 14.01 23 44358 51475 34861075
Oxygen saturation decreased 18.21 14.01 25 44356 53793 34858757
Blood urea increased 17.98 14.01 8 44373 30356 34882194
Prostatic specific antigen decreased 17.94 14.01 7 44374 154 34912396
Abscess oral 17.89 14.01 9 44372 368 34912182
Tremor 17.86 14.01 50 44331 82537 34830013
Sepsis 17.81 14.01 131 44250 166430 34746120
Intercepted product administration error 17.69 14.01 8 44373 257 34912293
Ulna fracture 17.32 14.01 9 44372 394 34912156
Injury associated with device 17.16 14.01 13 44368 1110 34911440
Sedation 17.12 14.01 3 44378 21003 34891547
Abdominal distension 17.09 14.01 30 44351 58462 34854088
Dental operation 17.07 14.01 9 44372 406 34912144
Calcium ionised abnormal 17.01 14.01 3 44378 0 34912550
Vipoma 16.91 14.01 4 44377 13 34912537
Somnolence 16.90 14.01 78 44303 111038 34801512
Soft tissue disorder 16.87 14.01 11 44370 739 34911811
Inappropriate schedule of product administration 16.85 14.01 136 44245 62160 34850390
Acute respiratory distress syndrome 16.76 14.01 6 44375 25963 34886587
Shock 16.63 14.01 5 44376 24174 34888376
Lactic acidosis 16.53 14.01 12 44369 34760 34877790
Headache 16.47 14.01 169 44212 200466 34712084
Extraskeletal ossification 16.43 14.01 5 44376 50 34912500
Postrenal failure 16.29 14.01 9 44372 446 34912104
Blood glucose increased 16.27 14.01 38 44343 66680 34845870
Agranulocytosis 16.25 14.01 5 44376 23816 34888734
Acute myocardial infarction 16.20 14.01 27 44354 53692 34858858
Blood parathyroid hormone decreased 16.00 14.01 14 44367 1466 34911084
Toxic epidermal necrolysis 15.78 14.01 4 44377 21642 34890908
Poor peripheral circulation 15.78 14.01 14 44367 1493 34911057
Dysgeusia 15.69 14.01 71 44310 26426 34886124
Blood 1,25-dihydroxycholecalciferol increased 15.54 14.01 4 44377 20 34912530
Neoplasm malignant 15.47 14.01 58 44323 19847 34892703
Intentional product use issue 15.46 14.01 33 44348 59783 34852767
Carcinoid tumour of the small bowel 15.42 14.01 7 44374 227 34912323
Osteosclerosis 15.28 14.01 13 44368 1311 34911239
Asthenia 15.15 14.01 413 43968 244838 34667712
Cellulitis 15.09 14.01 117 44264 52834 34859716
Orthostatic hypotension 15.08 14.01 7 44374 25912 34886638
Noninfective gingivitis 15.07 14.01 8 44373 366 34912184
SARS-CoV-2 test positive 15.01 14.01 27 44354 5906 34906644
Nasal discomfort 14.85 14.01 14 44367 1614 34910936
Bedridden 14.81 14.01 21 44360 3757 34908793
Dyspnoea 14.79 14.01 365 44016 376417 34536133
Vitamin D increased 14.71 14.01 5 44376 73 34912477
Hypersensitivity 14.69 14.01 35 44346 61000 34851550
Paraesthesia 14.68 14.01 135 44246 64037 34848513
Product use issue 14.63 14.01 37 44344 63179 34849371
Oral cavity fistula 14.52 14.01 6 44375 154 34912396
Ascites 14.43 14.01 23 44358 46548 34866002
Bone giant cell tumour 14.40 14.01 4 44377 28 34912522
Lung cyst 14.40 14.01 4 44377 28 34912522
Cardiogenic shock 14.28 14.01 8 44373 26610 34885940
Anaphylactic reaction 14.27 14.01 12 44369 32289 34880261
Rebound effect 14.03 14.01 19 44362 3255 34909295

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 25747.47 11.32 20240 194722 886975 78642451
Osteonecrosis of jaw 14195.32 11.32 5060 209902 38166 79491260
Death 6161.63 11.32 7570 207392 558944 78970482
Hypocalcaemia 2498.10 11.32 1599 213363 48325 79481101
Bone pain 1813.92 11.32 1371 213591 54371 79475055
Tooth disorder 1697.99 11.32 991 213971 25242 79504184
Spinal fracture 1571.48 11.32 829 214133 17225 79512201
Atypical femur fracture 1407.36 11.32 529 214433 4660 79524766
Pain in jaw 1371.94 11.32 1076 213886 45075 79484351
Tooth extraction 1329.22 11.32 631 214331 10364 79519062
Back pain 1253.48 11.32 2622 212340 301558 79227868
Pain in extremity 1058.59 11.32 2739 212223 361799 79167627
Drug ineffective 893.52 11.32 963 213999 1079950 78449476
Bone density abnormal 884.82 11.32 327 214635 2733 79526693
Metastases to bone 790.06 11.32 599 214363 23828 79505598
Arthralgia 783.98 11.32 3330 211632 568473 78960953
Thoracic vertebral fracture 771.04 11.32 345 214617 4908 79524518
Toxicity to various agents 769.59 11.32 111 214851 421429 79107997
Tooth fracture 723.27 11.32 427 214535 11103 79518323
Myalgia 716.75 11.32 1560 213402 184081 79345345
Lumbar vertebral fracture 669.86 11.32 343 214619 6679 79522747
Toothache 666.44 11.32 499 214463 19471 79509955
Terminal state 638.44 11.32 296 214666 4593 79524833
Exposed bone in jaw 629.31 11.32 270 214692 3450 79525976
Completed suicide 615.81 11.32 9 214953 245758 79283668
Rebound effect 595.37 11.32 320 214642 6906 79522520
Bone density decreased 587.68 11.32 395 214567 12952 79516474
Femur fracture 549.93 11.32 597 214365 38055 79491371
Jaw disorder 516.91 11.32 258 214704 4748 79524678
Blood parathyroid hormone increased 504.78 11.32 226 214736 3219 79526207
Drug interaction 488.76 11.32 255 214707 414928 79114498
Spinal compression fracture 483.50 11.32 386 214576 16572 79512854
Pathological fracture 469.09 11.32 314 214648 10223 79519203
Hospitalisation 438.77 11.32 856 214106 93380 79436046
Investigation 432.12 11.32 181 214781 2170 79527256
Acute kidney injury 431.29 11.32 459 214503 518945 79010481
Tooth loss 428.03 11.32 256 214706 6819 79522607
Drug abuse 421.04 11.32 3 214959 162688 79366738
Groin pain 412.44 11.32 316 214646 12764 79516662
Dental implantation 404.11 11.32 120 214842 452 79528974
Condition aggravated 396.08 11.32 461 214501 500663 79028763
Osteomyelitis 391.57 11.32 463 214499 32402 79497024
Loose tooth 386.21 11.32 182 214780 2935 79526491
Hip fracture 384.23 11.32 444 214518 30317 79499109
Breast cancer metastatic 351.21 11.32 243 214719 8359 79521067
Bone loss 349.50 11.32 160 214802 2407 79527019
Hypotension 339.34 11.32 413 214549 439904 79089522
Neoplasm progression 329.94 11.32 539 214423 51143 79478283
Fracture 321.06 11.32 343 214619 21458 79507968
Infusion related reaction 319.19 11.32 111 214851 230126 79299300
Dental care 313.69 11.32 111 214851 807 79528619
Dental caries 311.51 11.32 257 214705 11563 79517863
Musculoskeletal pain 307.09 11.32 780 214182 101574 79427852
Blood calcium decreased 303.45 11.32 401 214561 31418 79498008
Accidental exposure to product 302.21 11.32 397 214565 30925 79498501
Drug intolerance 289.27 11.32 177 214785 263942 79265484
Synovitis 288.30 11.32 34 214928 150700 79378726
Maternal exposure during pregnancy 284.36 11.32 22 214940 136516 79392910
Metastases to liver 284.28 11.32 366 214596 27948 79501478
Treatment failure 277.78 11.32 60 214902 170426 79359000
Bone disorder 269.68 11.32 294 214668 18819 79510607
Intentional overdose 269.15 11.32 3 214959 105957 79423469
Product use in unapproved indication 266.97 11.32 173 214789 250186 79279240
Overdose 260.16 11.32 86 214876 184120 79345306
Contraindicated product administered 255.53 11.32 56 214906 157482 79371944
Exostosis of jaw 252.33 11.32 103 214859 1151 79528275
Exposure during pregnancy 247.79 11.32 5 214957 101127 79428299
Foot fracture 244.36 11.32 299 214663 21682 79507744
Blood calcium increased 243.00 11.32 211 214751 10189 79519237
Jaw operation 241.18 11.32 89 214873 740 79528686
Product storage error 240.18 11.32 256 214706 15970 79513456
Malignant neoplasm progression 238.78 11.32 858 214104 135132 79394294
Drug hypersensitivity 236.87 11.32 274 214688 298642 79230784
Pemphigus 236.07 11.32 7 214955 99575 79429851
Endodontic procedure 235.88 11.32 125 214837 2618 79526808
Prostatic specific antigen increased 231.21 11.32 205 214757 10181 79519245
Product use issue 227.77 11.32 142 214820 209680 79319746
Cardiac arrest 221.77 11.32 93 214869 172003 79357423
Confusional state 219.62 11.32 323 214639 317674 79211752
Therapeutic product effect decreased 218.59 11.32 84 214878 163779 79365647
Osteitis 213.72 11.32 133 214829 3810 79525616
Muscle spasms 197.29 11.32 963 213999 173767 79355659
Tooth abscess 192.45 11.32 228 214734 15982 79513444
Incorrect route of product administration 192.14 11.32 341 214621 34588 79494838
Bradycardia 191.88 11.32 63 214899 135494 79393932
Osteonecrosis 185.97 11.32 315 214647 30780 79498646
Compression fracture 184.03 11.32 147 214815 6313 79523113
Systemic lupus erythematosus 182.92 11.32 50 214912 121099 79408327
Gingival disorder 182.51 11.32 117 214845 3534 79525892
Suicide attempt 179.53 11.32 11 214951 82921 79446505
Hepatic enzyme increased 179.04 11.32 138 214824 182472 79346954
Stress fracture 177.27 11.32 144 214818 6336 79523090
Spinal pain 176.99 11.32 213 214749 15179 79514247
Mobility decreased 173.64 11.32 721 214241 121454 79407972
Gingivitis 171.48 11.32 163 214799 8858 79520568
Abscess jaw 171.45 11.32 87 214875 1660 79527766
Somnolence 168.61 11.32 239 214723 238742 79290684
Tachycardia 168.44 11.32 139 214823 177629 79351797
Wrist fracture 167.53 11.32 183 214779 11738 79517688
Hypercalcaemia 166.62 11.32 339 214623 38091 79491335
Pericarditis 165.10 11.32 39 214923 104197 79425229
Joint swelling 162.08 11.32 334 214628 288312 79241114
Temporomandibular joint syndrome 161.03 11.32 111 214851 3794 79525632
Tetany 160.59 11.32 97 214865 2631 79526795
Gingival pain 160.51 11.32 157 214805 8841 79520585
Cardio-respiratory arrest 159.71 11.32 47 214915 108463 79420963
Metastases to lung 159.60 11.32 220 214742 17943 79511483
Cystitis 159.26 11.32 403 214559 52329 79477097
Coma 158.74 11.32 38 214924 100611 79428815
Febrile neutropenia 158.07 11.32 236 214726 230763 79298663
Hypophosphataemia 156.96 11.32 229 214733 19684 79509742
Blood calcium abnormal 156.56 11.32 76 214886 1313 79528113
Intentional product use issue 155.51 11.32 110 214852 152002 79377424
Breast cancer 153.64 11.32 304 214658 33477 79495949
Lactic acidosis 153.31 11.32 9 214953 70350 79459076
Atypical fracture 152.42 11.32 61 214901 645 79528781
Helicobacter infection 151.62 11.32 9 214953 69695 79459731
Pelvic fracture 150.44 11.32 175 214787 12029 79517397
Periodontitis 149.19 11.32 112 214850 4384 79525042
Dyspnoea 147.87 11.32 1538 213424 855487 78673939
Sequestrectomy 147.23 11.32 63 214899 799 79528627
Duodenal ulcer perforation 145.71 11.32 8 214954 66203 79463223
Pyrexia 145.28 11.32 1153 213809 677556 78851870
Multiple organ dysfunction syndrome 142.46 11.32 73 214889 120173 79409253
Hand deformity 142.38 11.32 51 214911 103868 79425558
Gastrointestinal haemorrhage 140.55 11.32 115 214847 147604 79381822
Tooth infection 140.43 11.32 211 214751 18621 79510805
Vomiting 139.79 11.32 1137 213825 664691 78864735
Multiple fractures 139.37 11.32 138 214824 7888 79521538
Gingival swelling 137.99 11.32 108 214854 4501 79524925
Artificial crown procedure 136.74 11.32 44 214918 229 79529197
Agitation 136.50 11.32 49 214913 99666 79429760
Hyperaesthesia teeth 136.17 11.32 76 214886 1770 79527656
Osteonecrosis of external auditory canal 136.10 11.32 40 214922 144 79529282
Gingival recession 135.84 11.32 67 214895 1200 79528226
Fall 135.68 11.32 1953 213009 485676 79043750
Occupational exposure to product 132.37 11.32 55 214907 645 79528781
Carbohydrate antigen 15-3 increased 131.35 11.32 64 214898 1115 79528311
Depressed level of consciousness 129.77 11.32 49 214913 96603 79432823
International normalised ratio increased 129.71 11.32 34 214928 84687 79444739
Metastases to lymph nodes 128.01 11.32 149 214813 10248 79519178
Eczema 126.45 11.32 315 214647 40503 79488923
Hypoglycaemia 124.40 11.32 59 214903 101535 79427891
Suicidal ideation 122.01 11.32 28 214934 76312 79453114
Psoriatic arthropathy 121.92 11.32 30 214932 77969 79451457
Dental restoration failure 120.51 11.32 57 214905 927 79528499
Seizure 119.63 11.32 203 214759 188631 79340795
Abdominal pain 119.31 11.32 592 214370 388977 79140449
Wound 118.76 11.32 84 214878 116095 79413331
Folliculitis 117.92 11.32 8 214954 55372 79474054
Metabolic acidosis 117.39 11.32 38 214924 82491 79446935
Respiratory failure 116.90 11.32 192 214770 180719 79348707
Glossodynia 116.19 11.32 67 214895 103270 79426156
Musculoskeletal discomfort 116.05 11.32 199 214763 19636 79509790
Rib fracture 115.81 11.32 242 214720 27705 79501721
Tumour marker increased 110.71 11.32 92 214870 4180 79525246
Wheezing 109.52 11.32 92 214870 116572 79412854
Mastication disorder 109.24 11.32 76 214886 2637 79526789
Unresponsive to stimuli 108.09 11.32 12 214950 55776 79473650
Metastases to central nervous system 107.48 11.32 173 214789 16202 79513224
Pneumonia 107.17 11.32 1201 213761 659045 78870381
Weight increased 106.81 11.32 386 214576 277000 79252426
Serotonin syndrome 103.76 11.32 4 214958 45023 79484403
Metastases to spine 103.59 11.32 89 214873 4235 79525191
Oxygen saturation decreased 103.50 11.32 117 214845 128930 79400496
Hyponatraemia 103.01 11.32 202 214760 177646 79351780
Respiratory arrest 102.83 11.32 16 214946 57534 79471892
Vitamin D decreased 101.21 11.32 128 214834 9597 79519829
Muscle injury 100.58 11.32 8 214954 48553 79480873
Upper limb fracture 99.57 11.32 176 214786 17791 79511635
Prostate cancer metastatic 99.11 11.32 84 214878 3923 79525503
Bedridden 98.25 11.32 141 214821 11938 79517488
Hypoxia 96.19 11.32 82 214880 103161 79426265
Lower limb fracture 95 11.32 200 214762 23015 79506411
Encephalopathy 92.44 11.32 33 214929 67364 79462062
Femoral neck fracture 92.37 11.32 124 214838 9860 79519566
C-reactive protein abnormal 92.22 11.32 11 214951 48356 79481070
Rash pruritic 91.18 11.32 409 214553 71220 79458206
Alanine aminotransferase increased 90.43 11.32 189 214773 162381 79367045
Liver injury 90 11.32 21 214941 56593 79472833
Dental operation 88.89 11.32 49 214913 1113 79528313
Rhabdomyolysis 88.86 11.32 88 214874 103043 79426383
Septic shock 88.35 11.32 121 214841 122680 79406746
Anaphylactic reaction 86.30 11.32 60 214902 83683 79445743
Fractured sacrum 85.48 11.32 54 214908 1589 79527837
Hyperkalaemia 84.05 11.32 111 214851 114287 79415139
Hot flush 83.59 11.32 331 214631 54546 79474880
Hyperparathyroidism 82.66 11.32 69 214893 3155 79526271
Pain 81.80 11.32 2478 212484 701324 78828102
Drug level increased 80.83 11.32 7 214955 39644 79489782
Multiple sclerosis relapse 80.77 11.32 14 214948 46519 79482907
Neoplasm malignant 80.76 11.32 228 214734 31582 79497844
Toxic epidermal necrolysis 80.55 11.32 12 214950 44569 79484857
Jaw fistula 80.29 11.32 24 214938 93 79529333
Oral pain 79.84 11.32 227 214735 31571 79497855
Sepsis 79.81 11.32 414 214548 269014 79260412
Drug reaction with eosinophilia and systemic symptoms 79.12 11.32 37 214925 64207 79465219
Hospice care 78.87 11.32 117 214845 10207 79519219
Aggression 78.86 11.32 20 214942 50938 79478488
Influenza like illness 78.55 11.32 392 214570 71315 79458111
Body height decreased 78.52 11.32 106 214856 8474 79520952
Renal failure 78.43 11.32 278 214684 200690 79328736
Dental fistula 78.26 11.32 35 214927 497 79528929
Hypersensitivity 78.21 11.32 402 214560 261837 79267589
Paraesthesia 77.47 11.32 771 214191 175552 79353874
Abdominal discomfort 77.26 11.32 380 214582 250347 79279079
Inappropriate schedule of product administration 77.05 11.32 620 214342 133008 79396418
Gingival abscess 76.60 11.32 40 214922 812 79528614
Hallucination 76.39 11.32 71 214891 85674 79443752
Gait disturbance 76.09 11.32 875 214087 206631 79322795
Intercepted product administration error 74.91 11.32 32 214930 404 79529022
Eosinophilia 73.73 11.32 16 214946 45329 79484097
Tooth erosion 73.61 11.32 31 214931 377 79529049
Dermatitis 72.95 11.32 171 214791 21150 79508276
Product dose omission issue 72.90 11.32 1002 213960 246535 79282891
Syncope 72.88 11.32 244 214718 179205 79350221
Rheumatoid arthritis 72.57 11.32 302 214660 208168 79321258
Blood pressure decreased 72.57 11.32 97 214865 99369 79430057
Lower respiratory tract infection 72.05 11.32 150 214812 129070 79400356
Bone lesion 71.49 11.32 84 214878 5835 79523591
Intentional self-injury 71.07 11.32 4 214958 32415 79497011
Impaired healing 69.95 11.32 440 214522 87215 79442211
Oedema 69.93 11.32 135 214827 119445 79409981
Tibia fracture 69.66 11.32 79 214883 5282 79524144
Pancytopenia 68.94 11.32 223 214739 165522 79363904
Joint noise 68.39 11.32 68 214894 3906 79525520
Metastasis 67.58 11.32 88 214874 6792 79522634
Type 2 diabetes mellitus 67.16 11.32 35 214927 57087 79472339
Ventricular fibrillation 66.85 11.32 5 214957 31921 79497505
Neck pain 66.80 11.32 389 214573 75028 79454398
Orthostatic hypotension 66.65 11.32 34 214928 56130 79473296
Humerus fracture 66.12 11.32 102 214860 9211 79520215
Aspartate aminotransferase increased 66.04 11.32 175 214787 138466 79390960
Chest discomfort 65.94 11.32 174 214788 137870 79391556
Dry skin 65.03 11.32 358 214604 67637 79461789
Tooth resorption 64.92 11.32 16 214946 22 79529404
Chest pain 64.70 11.32 470 214492 281834 79247592
Blood creatine phosphokinase increased 64.66 11.32 50 214912 66040 79463386
Dental cleaning 64.46 11.32 15 214947 13 79529413
Loss of consciousness 64.40 11.32 234 214728 167709 79361717
Delirium 64.35 11.32 80 214882 84547 79444879
Abortion spontaneous 63.59 11.32 4 214958 29503 79499923
Haematochezia 63.40 11.32 86 214876 87559 79441867
Musculoskeletal chest pain 63.36 11.32 178 214784 24586 79504840
C-telopeptide increased 63.21 11.32 14 214948 7 79529419
Dental necrosis 63.13 11.32 22 214940 152 79529274
Pulpitis dental 62.98 11.32 41 214921 1272 79528154
Mental status changes 62.59 11.32 53 214909 66906 79462520
Injury 62.41 11.32 70 214892 77426 79452000
Prescribed overdose 62.34 11.32 13 214949 37870 79491556
Cytokine release syndrome 62.11 11.32 11 214951 35987 79493439
Intentional product misuse 61.44 11.32 101 214861 95064 79434362
Drug withdrawal syndrome 61.24 11.32 10 214952 34708 79494718
Blood phosphorus decreased 60.44 11.32 82 214880 6586 79522840
Dysarthria 60.23 11.32 56 214906 67566 79461860
Coronary artery disease 59.77 11.32 53 214909 65421 79464005
Swelling 59.75 11.32 341 214621 216370 79313056
Generalised tonic-clonic seizure 59.37 11.32 22 214940 43888 79485538
Sedation 59.25 11.32 33 214929 51862 79477564
Bone giant cell tumour malignant 59.03 11.32 12 214950 0 79529426
Labelled drug-drug interaction medication error 58.85 11.32 4 214958 27646 79501780
Mouth swelling 58.82 11.32 77 214885 5974 79523452
Cytomegalovirus infection 58.27 11.32 21 214941 42623 79486803
Acute respiratory distress syndrome 58.05 11.32 23 214939 44044 79485382
Product prescribing error 58.04 11.32 24 214938 44789 79484637
Parathyroid disorder 58.03 11.32 28 214934 477 79528949
Asthma 57.41 11.32 180 214782 134915 79394511
Device expulsion 57.29 11.32 3 214959 25858 79503568
Sleep disorder due to a general medical condition 57.26 11.32 122 214840 14155 79515271
Anxiety 56.81 11.32 414 214548 248098 79281328
Scoliosis 56.17 11.32 84 214878 7380 79522046
Heart rate decreased 56.10 11.32 64 214898 70252 79459174
Respiratory distress 55.98 11.32 45 214917 58294 79471132
Haematemesis 55.79 11.32 36 214926 52228 79477198
Angioedema 55.61 11.32 74 214888 75961 79453465
Ventricular tachycardia 55.05 11.32 22 214940 41913 79487513
Cancer pain 54.52 11.32 69 214893 5176 79524250
Myocardial infarction 54.46 11.32 283 214679 183846 79345580
Radius fracture 54.10 11.32 57 214905 3507 79525919
Cardiogenic shock 53.39 11.32 23 214939 41891 79487535
Drug-induced liver injury 52.94 11.32 60 214902 66057 79463369
Poisoning 52.79 11.32 4 214958 25268 79504158
Jaw fracture 52.62 11.32 52 214910 2965 79526461
Osteoporosis 52.48 11.32 286 214676 53826 79475600
Periodontal disease 52.09 11.32 42 214920 1828 79527598
Living in residential institution 51.74 11.32 29 214933 681 79528745
C-reactive protein increased 51.31 11.32 177 214785 128850 79400576
Drug ineffective for unapproved indication 51.10 11.32 38 214924 51200 79478226
Infection 50.86 11.32 412 214550 241300 79288126
Sinus tachycardia 50.73 11.32 18 214944 36890 79492536
Ulna fracture 50.67 11.32 34 214928 1111 79528315
Hyperparathyroidism secondary 50.43 11.32 48 214914 2612 79526814
Denture wearer 50.41 11.32 16 214946 79 79529347
Headache 50.26 11.32 1360 213602 652412 78877014
Hand fracture 49.65 11.32 72 214890 6153 79523273
Renal tubular necrosis 49.49 11.32 5 214957 25034 79504392
Parathyroid tumour malignant 49.32 11.32 14 214948 43 79529383
Osteoporotic fracture 49.27 11.32 59 214903 4181 79525245
Emotional distress 49.24 11.32 23 214939 39946 79489480
Sinusitis 48.97 11.32 317 214645 195184 79334242
Hungry bone syndrome 48.86 11.32 19 214943 185 79529241
Respiratory depression 48.64 11.32 8 214954 27622 79501804
Hormone-refractory prostate cancer 48.35 11.32 24 214938 436 79528990
Irritable bowel syndrome 48.20 11.32 58 214904 62183 79467243
Blood bilirubin increased 47.89 11.32 65 214897 66167 79463259
Acute myocardial infarction 47.67 11.32 84 214878 76952 79452474
Stevens-Johnson syndrome 47.54 11.32 23 214939 39143 79490283
Ear pain 47.45 11.32 195 214767 32674 79496752
Tachypnoea 46.96 11.32 14 214948 32049 79497377
Oral cavity fistula 46.48 11.32 27 214935 680 79528746
No adverse event 46.44 11.32 21 214941 37171 79492255
Lymphoedema 46.28 11.32 103 214859 12310 79517116
Disease recurrence 46.25 11.32 31 214931 44078 79485348
Tremor 46.13 11.32 269 214693 169814 79359612
Vitamin D deficiency 46.13 11.32 112 214850 14167 79515259
Polymyalgia rheumatica 46.08 11.32 59 214903 4478 79524948
Medication error 46.06 11.32 71 214891 68571 79460855
Vitamin D abnormal 46.00 11.32 17 214945 142 79529284
Circulatory collapse 45.91 11.32 22 214940 37646 79491780
Dental discomfort 45.89 11.32 23 214939 427 79528999
Oral infection 45.51 11.32 66 214896 5641 79523785
Accidental overdose 45.43 11.32 25 214937 39556 79489870
Abnormal behaviour 44.80 11.32 21 214941 36400 79493026
Red blood cell sedimentation rate abnormal 44.71 11.32 3 214959 20960 79508466
Status epilepticus 44.65 11.32 7 214955 25034 79504392
Cardiac failure congestive 44.31 11.32 215 214747 142187 79387239
Peri-implantitis 44.26 11.32 18 214944 199 79529227
Tubulointerstitial nephritis 44.11 11.32 24 214938 38211 79491215
Parathyroidectomy 44.03 11.32 18 214944 202 79529224
Noninfective gingivitis 44.00 11.32 36 214926 1600 79527826
Coagulopathy 43.93 11.32 21 214941 35985 79493441
Liver function test abnormal 43.92 11.32 66 214896 64409 79465017
Blood parathyroid hormone abnormal 43.72 11.32 21 214941 354 79529072
Obesity 43.60 11.32 20 214942 35105 79494321
Hyperhidrosis 43.58 11.32 235 214727 151257 79378169
Psoriasis 43.48 11.32 112 214850 89475 79439951
Spinal operation 43.15 11.32 77 214885 7840 79521586
Atrial fibrillation 43.15 11.32 334 214628 197552 79331874
Spinal deformity 42.86 11.32 29 214933 961 79528465
Dehydration 42.69 11.32 445 214517 247742 79281684
Pulmonary oedema 42.32 11.32 111 214851 88143 79441283
Drug dependence 42.28 11.32 29 214933 40740 79488686
Therapeutic response decreased 42.18 11.32 72 214890 66781 79462645
Blood creatinine increased 41.64 11.32 246 214716 154811 79374615
Shock 41.28 11.32 34 214928 43514 79485912
Dyskinesia 41.16 11.32 36 214926 44737 79484689
Product quality issue 41.09 11.32 20 214942 33920 79495506
Red blood cell sedimentation rate increased 40.97 11.32 38 214924 45904 79483522
Urinary tract infection 40.67 11.32 998 213964 273514 79255912
Torsade de pointes 40.50 11.32 3 214959 19309 79510117
Agranulocytosis 40.44 11.32 37 214925 44993 79484433
Pulmonary arterial hypertension 40.44 11.32 13 214949 28353 79501073
Blister 40.37 11.32 175 214787 119301 79410125
Bronchopulmonary aspergillosis 40.28 11.32 6 214956 22288 79507138
Incorrect dose administered 40.18 11.32 92 214870 76538 79452888
Product substitution issue 40.15 11.32 4 214958 20252 79509174
Bone graft 40.14 11.32 25 214937 717 79528709
Aspergillus infection 40.12 11.32 3 214959 19158 79510268
Heart rate increased 40.08 11.32 178 214784 120546 79408880
White blood cell count increased 39.63 11.32 89 214873 74544 79454882
Thrombocytopenia 39.59 11.32 491 214471 264768 79264658
Pancreatitis 39.58 11.32 78 214884 68497 79460929
PIK3CA-activated mutation 39.57 11.32 23 214939 580 79528846
Acute myeloid leukaemia 39.26 11.32 17 214945 30868 79498558
Blood pressure increased 39.26 11.32 372 214590 210988 79318438
Haematoma 38.99 11.32 50 214912 52145 79477281
Fluid retention 38.93 11.32 81 214881 69728 79459698
Obstructive airways disorder 38.91 11.32 18 214944 31441 79497985
Sciatica 38.80 11.32 185 214777 33037 79496389
Right ventricular failure 38.79 11.32 8 214954 23489 79505937
Walking aid user 38.73 11.32 85 214877 10063 79519363
Premature delivery 38.72 11.32 8 214954 23459 79505967
Staphylococcal infection 38.44 11.32 61 214901 58234 79471192
Muscle spasticity 38.29 11.32 6 214956 21469 79507957
Device failure 38.19 11.32 64 214898 6197 79523229
Transplant rejection 38.11 11.32 4 214958 19433 79509993
Onychoclasis 38.07 11.32 60 214902 5518 79523908
Metastases to skin 38.06 11.32 34 214928 1705 79527721
Cholesteatoma 37.87 11.32 14 214948 117 79529309
Therapy non-responder 37.80 11.32 125 214837 92180 79437246
Hemiparesis 37.72 11.32 22 214940 33711 79495715
Oral surgery 37.36 11.32 28 214934 1093 79528333
Pallor 37.35 11.32 48 214914 50014 79479412
Hypervolaemia 37.26 11.32 36 214926 42654 79486772
Adverse reaction 36.67 11.32 79 214883 9235 79520191
Respiratory rate increased 36.40 11.32 7 214955 21593 79507833
Mydriasis 36.27 11.32 3 214959 17640 79511786
Palliative care 36.22 11.32 26 214936 949 79528477
Flushing 35.83 11.32 120 214842 88148 79441278
Diabetic ketoacidosis 35.75 11.32 24 214938 34098 79495328
Alopecia 35.74 11.32 846 214116 230509 79298917
Paranoia 35.64 11.32 5 214957 19427 79509999
Feeling abnormal 35.52 11.32 615 214347 158584 79370842
Dental prosthesis user 35.41 11.32 10 214952 30 79529396
Unevaluable event 35.40 11.32 264 214698 55321 79474105
Cyanosis 35.10 11.32 12 214950 25170 79504256
Parathyroid tumour 34.93 11.32 12 214950 79 79529347
Blood pressure fluctuation 34.90 11.32 81 214881 67064 79462362
Shock haemorrhagic 34.89 11.32 6 214956 20054 79509372
Psychotic disorder 34.89 11.32 36 214926 41366 79488060
Upper gastrointestinal haemorrhage 34.85 11.32 36 214926 41344 79488082
Ataxia 34.78 11.32 12 214950 25027 79504399
Blood alkaline phosphatase decreased 34.50 11.32 33 214929 1807 79527619
Blood glucose increased 34.38 11.32 176 214786 114799 79414627
Restlessness 34.25 11.32 45 214917 46447 79482979
Acute respiratory failure 34.12 11.32 68 214894 59473 79469953
Disorientation 34.03 11.32 74 214888 62702 79466724
Pneumocystis jirovecii pneumonia 33.87 11.32 23 214939 32485 79496941
Kyphosis 33.86 11.32 39 214923 2652 79526774
Dental prosthesis placement 33.79 11.32 9 214953 20 79529406
Withdrawal syndrome 33.79 11.32 15 214947 26839 79502587
Metastases to meninges 33.73 11.32 45 214917 3556 79525870
Nerve compression 33.70 11.32 76 214886 9163 79520263
Bone marrow failure 33.21 11.32 54 214908 51053 79478373
Hypothermia 33.19 11.32 10 214952 22736 79506690
Musculoskeletal disorder 33.16 11.32 130 214832 21318 79508108
Parathyroid tumour benign 33.11 11.32 23 214939 796 79528630
Oral discomfort 33.09 11.32 78 214884 9682 79519744
Haemodynamic instability 33.02 11.32 4 214958 17378 79512048
Gingival erythema 33.00 11.32 21 214941 626 79528800
Bone sequestrum 32.96 11.32 27 214935 1202 79528224
Injection site reaction 32.76 11.32 61 214901 54724 79474702
Intercepted medication error 32.75 11.32 24 214938 905 79528521
Cognitive disorder 32.73 11.32 89 214873 69837 79459589
Menopausal symptoms 32.70 11.32 33 214929 1930 79527496
Bone swelling 32.63 11.32 31 214931 1683 79527743
Gingival operation 32.47 11.32 11 214951 69 79529357
Intervertebral disc protrusion 32.43 11.32 138 214824 23483 79505943
Mastectomy 32.36 11.32 26 214936 1126 79528300
Pleural neoplasm 32.29 11.32 17 214945 351 79529075
Blood urea increased 32.22 11.32 51 214911 48739 79480687
Hypoaesthesia 32.17 11.32 670 214292 178682 79350744
Decreased immune responsiveness 32.12 11.32 55 214907 5420 79524006
Leukocytosis 32.07 11.32 42 214920 43413 79486013
Pulmonary hypertension 32.00 11.32 50 214912 48030 79481396
Nausea 31.82 11.32 2188 212774 955008 78574418
Delusion of grandeur 31.34 11.32 28 214934 1404 79528022
Injection site erythema 31.27 11.32 107 214855 78090 79451336
Muscle tightness 31.26 11.32 91 214871 12823 79516603
Melaena 31.21 11.32 74 214888 60816 79468610
Haemoptysis 31.20 11.32 65 214897 55934 79473492
Dizziness 31.19 11.32 1133 213829 525308 79004118
Bone fissure 31.17 11.32 13 214949 154 79529272
Irritability 31.16 11.32 39 214923 41105 79488321
Haematocrit decreased 31.04 11.32 75 214887 61237 79468189
Calcinosis 30.98 11.32 35 214927 2330 79527096
Wrong technique in product usage process 30.95 11.32 320 214642 73555 79455871
Angina unstable 30.91 11.32 4 214958 16523 79512903
Oedema peripheral 30.87 11.32 486 214476 251802 79277624
Pseudomonas infection 30.84 11.32 9 214953 20894 79508532
Ankle fracture 30.54 11.32 108 214854 16861 79512565
Cataract operation 30.30 11.32 52 214910 5133 79524293
Nightmare 30.17 11.32 16 214946 25845 79503581
Hypoaesthesia oral 29.95 11.32 95 214867 14029 79515397
Delusion 29.76 11.32 9 214953 20414 79509012
Angina pectoris 29.72 11.32 59 214903 51673 79477753
Hepatic encephalopathy 29.62 11.32 14 214948 24152 79505274
Renal injury 29.58 11.32 5 214957 16922 79512504
Breast disorder 29.33 11.32 32 214930 2049 79527377
Hepatitis 29.14 11.32 67 214895 55660 79473766
Breast cancer recurrent 29.12 11.32 38 214924 2939 79526487
Nasal congestion 29.10 11.32 107 214855 76445 79452981
Circumstance or information capable of leading to medication error 29.10 11.32 44 214918 3904 79525522
Arthritis 29.03 11.32 453 214509 114427 79414999
Drug resistance 28.96 11.32 43 214919 42170 79487256
White blood cell count decreased 28.91 11.32 688 214274 187600 79341826
Aphasia 28.87 11.32 51 214911 46681 79482745
Discomfort 28.81 11.32 209 214753 125408 79404018
Osteolysis 28.81 11.32 47 214915 4451 79524975
Deep vein thrombosis 28.80 11.32 199 214763 120720 79408706
Musculoskeletal stiffness 28.79 11.32 317 214645 174691 79354735
Nasopharyngitis 28.78 11.32 496 214466 253385 79276041
Subarachnoid haemorrhage 28.74 11.32 15 214947 24450 79504976
Pneumonia aspiration 28.60 11.32 89 214873 66878 79462548
Forearm fracture 28.42 11.32 18 214944 532 79528894
Colitis ulcerative 28.39 11.32 31 214931 34711 79494715
Photophobia 28.23 11.32 10 214952 20518 79508908
Epstein-Barr virus infection 28.18 11.32 3 214959 14413 79515013
Pancreatitis acute 28.13 11.32 57 214905 49547 79479879
Hyperthermia 28.06 11.32 7 214955 18030 79511396
Arthropathy 27.88 11.32 324 214638 176787 79352639
Myelosuppression 27.69 11.32 41 214921 40255 79489171
Adverse drug reaction 27.54 11.32 287 214675 66105 79463321
Anuria 27.51 11.32 11 214951 20952 79508474
Back disorder 27.47 11.32 81 214881 11497 79517929
Thrombotic microangiopathy 27.44 11.32 10 214952 20159 79509267
Depression 27.41 11.32 415 214547 216375 79313051
Metastases to bladder 27.31 11.32 14 214948 273 79529153
Dysstasia 27.13 11.32 147 214815 27599 79501827
Bone fistula 27.11 11.32 10 214952 83 79529343
Rales 27.07 11.32 10 214952 19991 79509435
Tumour marker abnormal 27.00 11.32 14 214948 280 79529146
Blood 1,25-dihydroxycholecalciferol increased 26.97 11.32 8 214954 30 79529396
Altered state of consciousness 26.91 11.32 48 214914 43774 79485652
Posterior reversible encephalopathy syndrome 26.85 11.32 19 214943 26262 79503164
Weight bearing difficulty 26.78 11.32 38 214924 3183 79526243
Haemorrhage intracranial 26.67 11.32 19 214943 26174 79503252
Abscess oral 26.62 11.32 26 214936 1461 79527965
Creatinine renal clearance decreased 26.58 11.32 9 214953 18993 79510433
Metaphyseal corner fracture 26.56 11.32 8 214954 32 79529394
Acidosis 26.55 11.32 10 214952 19752 79509674
Haemodialysis 26.48 11.32 8 214954 18160 79511266
Tartrate-resistant acid phosphatase increased 26.46 11.32 6 214956 4 79529422
Therapeutic product effect incomplete 26.42 11.32 249 214713 141396 79388030
Haemorrhage 26.39 11.32 141 214821 90977 79438449
Acute coronary syndrome 26.28 11.32 12 214950 21121 79508305
Limb discomfort 26.26 11.32 165 214797 32685 79496741
Sinus bradycardia 26.12 11.32 18 214944 25229 79504197
Disturbance in attention 25.82 11.32 62 214900 50739 79478687
Haemoglobin decreased 25.80 11.32 432 214530 221687 79307739
Jaundice 25.65 11.32 67 214895 53282 79476144
Pulmonary fibrosis 25.60 11.32 50 214912 44062 79485364
Pathogen resistance 25.59 11.32 4 214958 14338 79515088
Bone resorption test abnormal 25.37 11.32 6 214956 6 79529420
Bronchospasm 25.36 11.32 18 214944 24841 79504585
Activated partial thromboplastin time prolonged 25.31 11.32 4 214958 14224 79515202
Bone formation increased 25.25 11.32 9 214953 67 79529359
Abdominal lymphadenopathy 25.16 11.32 24 214938 1310 79528116
Osteoarthritis 25.08 11.32 352 214610 86957 79442469
Immune system disorder 25.07 11.32 76 214886 10953 79518473
Hepatocellular injury 25.06 11.32 57 214905 47536 79481890
Dementia 25.04 11.32 132 214830 24527 79504899
Atelectasis 25.04 11.32 30 214932 32227 79497199
Immobile 25.03 11.32 57 214905 6916 79522510
Migraine 25.00 11.32 136 214826 87357 79442069
COVID-19 24.99 11.32 288 214674 157386 79372040
Rehabilitation therapy 24.97 11.32 28 214934 1849 79527577
Device dislocation 24.96 11.32 20 214942 25950 79503476
Osteosclerosis 24.77 11.32 41 214921 3930 79525496
Paraesthesia oral 24.63 11.32 115 214847 20356 79509070
Bone deformity 24.63 11.32 14 214948 338 79529088
Trismus 24.61 11.32 49 214913 5418 79524008
Oral neoplasm benign 24.59 11.32 5 214957 0 79529426
Calcium ionised abnormal 24.59 11.32 5 214957 0 79529426
Cellulitis 24.57 11.32 422 214540 108638 79420788
Myoclonus 24.52 11.32 23 214939 27637 79501789
Hair disorder 24.51 11.32 22 214940 1110 79528316
Cardiac failure 24.47 11.32 283 214679 154559 79374867
Carcinoembryonic antigen increased 24.47 11.32 30 214932 2179 79527247
Rectal haemorrhage 24.42 11.32 114 214848 76186 79453240
Polyneuropathy in malignant disease 24.41 11.32 13 214949 275 79529151
Hepatitis cholestatic 24.41 11.32 4 214958 13848 79515578
Vertebroplasty 24.24 11.32 13 214949 279 79529147
Vitamin D increased 24.18 11.32 17 214945 600 79528826
Acetabulum fracture 24.01 11.32 17 214945 607 79528819
Gingival injury 23.86 11.32 7 214955 25 79529401
Hallucination, visual 23.78 11.32 32 214930 32697 79496729
Heart rate irregular 23.69 11.32 32 214930 32647 79496779
Progressive multifocal leukoencephalopathy 23.66 11.32 13 214949 20587 79508839
Hip surgery 23.60 11.32 36 214926 3219 79526207
Drug level decreased 23.58 11.32 5 214957 14397 79515029
Bone cancer 23.39 11.32 28 214934 1984 79527442
Peripheral swelling 23.29 11.32 551 214411 269066 79260360
Inappropriate antidiuretic hormone secretion 23.18 11.32 22 214940 26291 79503135
Adnexa uteri mass 23.17 11.32 14 214948 380 79529046
Rash macular 23.00 11.32 145 214817 28754 79500672
Akathisia 22.98 11.32 4 214958 13255 79516171
Hypophosphatasia 22.75 11.32 8 214954 57 79529369
Subdural haematoma 22.57 11.32 31 214931 31403 79498023
Hepatic cytolysis 22.44 11.32 24 214938 27127 79502299
Frequent bowel movements 22.37 11.32 28 214934 29511 79499915
Pulmonary haemorrhage 22.34 11.32 6 214956 14711 79514715
Acute hepatic failure 22.33 11.32 29 214933 30084 79499342
Sleep disorder due to general medical condition, insomnia type 22.27 11.32 53 214909 43503 79485923
Basal cell carcinoma 22.01 11.32 42 214920 37333 79492093
Bacteraemia 21.97 11.32 34 214928 32790 79496636
Lower gastrointestinal haemorrhage 21.93 11.32 8 214954 16117 79513309
Nephropathy toxic 21.88 11.32 14 214948 20405 79509021
Hepatic lesion 21.86 11.32 54 214908 6905 79522521
Enthesopathy 21.26 11.32 3 214959 11605 79517821
Gingival ulceration 21.18 11.32 19 214943 958 79528468
Patella fracture 21.13 11.32 26 214936 1895 79527531
Triple negative breast cancer 21.11 11.32 9 214953 113 79529313
Anger 20.95 11.32 10 214952 17152 79512274
Dysgeusia 20.88 11.32 241 214721 56936 79472490
Hyperglycaemia 20.83 11.32 108 214854 70227 79459199
Sudden death 20.81 11.32 18 214944 22493 79506933
Thyroid operation 20.64 11.32 10 214952 172 79529254
Vaccination site reaction 20.63 11.32 9 214953 120 79529306
Myocardial ischaemia 20.60 11.32 23 214939 25496 79503930
Oral disorder 20.58 11.32 67 214895 10028 79519398
Lichen planus 20.42 11.32 31 214931 2760 79526666
Traumatic fracture 20.41 11.32 19 214943 1005 79528421
Root canal infection 20.41 11.32 13 214949 388 79529038
Injection site pruritus 20.41 11.32 53 214909 42230 79487196
Erysipelas 20.34 11.32 70 214892 10780 79518646
Quality of life decreased 20.21 11.32 68 214894 10352 79519074
Drug dose omission by device 20.16 11.32 49 214913 6201 79523225
Brain oedema 20.14 11.32 23 214939 25240 79504186
Prostate cancer recurrent 19.93 11.32 17 214945 801 79528625
Coordination abnormal 19.77 11.32 11 214951 17301 79512125
Chemotherapy 19.69 11.32 24 214938 1733 79527693
Serum procollagen type I N-terminal propeptide decreased 19.68 11.32 4 214958 0 79529426
Haematuria 19.66 11.32 107 214855 68729 79460697
Acute generalised exanthematous pustulosis 19.65 11.32 11 214951 17243 79512183
Pleurocutaneous fistula 19.65 11.32 7 214955 52 79529374
Scab 19.64 11.32 68 214894 10504 79518922
Presyncope 19.40 11.32 52 214910 41002 79488424
Electrocardiogram QRS complex prolonged 19.38 11.32 3 214959 10830 79518596
Productive cough 19.28 11.32 149 214813 88182 79441244
Hepatic failure 19.27 11.32 92 214870 61120 79468306
Caesarean section 19.24 11.32 5 214957 12530 79516896
Oligodipsia 19.18 11.32 6 214956 28 79529398
Ascites 19.17 11.32 122 214840 75440 79453986
Hypovolaemia 19.13 11.32 12 214950 17679 79511747
Medial tibial stress syndrome 19.10 11.32 9 214953 145 79529281
Rotator cuff syndrome 19.08 11.32 82 214880 14013 79515413
Rash maculo-papular 19.02 11.32 82 214880 55996 79473430
Bone scan abnormal 18.93 11.32 10 214952 208 79529218
Metastases to neck 18.84 11.32 6 214956 30 79529396
Hepatomegaly 18.82 11.32 14 214948 18860 79510566
Rash papular 18.73 11.32 112 214850 21804 79507622
Bone marrow oedema 18.57 11.32 23 214939 1688 79527738
Breath sounds abnormal 18.48 11.32 10 214952 15974 79513452
Hypokalaemia 18.45 11.32 275 214687 143765 79385661
Prostate cancer 18.42 11.32 153 214809 33115 79496311
Haemophagocytic lymphohistiocytosis 18.38 11.32 19 214943 21818 79507608
Diffuse large B-cell lymphoma 18.35 11.32 5 214957 12144 79517282
Facet joint syndrome 18.35 11.32 4 214958 11298 79518128
Exostosis 18.34 11.32 92 214870 16766 79512660
Device fastener issue 18.25 11.32 8 214954 108 79529318
Clavicle fracture 18.22 11.32 38 214924 4343 79525083
Failure to anastomose 18.19 11.32 10 214952 226 79529200
Pneumonia fungal 18.13 11.32 4 214958 11206 79518220
Respiratory acidosis 18.11 11.32 4 214958 11196 79518230
Transaminases increased 17.96 11.32 75 214887 51668 79477758
Sarcoma 17.96 11.32 17 214945 919 79528507
Tricuspid valve incompetence 17.94 11.32 16 214946 19696 79509730
Metastases to bone marrow 17.85 11.32 16 214946 806 79528620
CYP3A4 polymorphism 17.84 11.32 7 214955 70 79529356
Pollakiuria 17.75 11.32 166 214796 37151 79492275
Prostatic specific antigen decreased 17.75 11.32 7 214955 71 79529355
Oliguria 17.73 11.32 11 214951 16298 79513128
Onychalgia 17.71 11.32 17 214945 935 79528491
Infusion site pain 17.71 11.32 8 214954 14168 79515258
Macroenzyme creatine kinase 17.70 11.32 5 214957 15 79529411
Lung neoplasm malignant 17.69 11.32 132 214830 27660 79501766
Lymphocyte count abnormal 17.61 11.32 21 214941 1482 79527944
Aspiration 17.59 11.32 17 214945 20141 79509285
Splenomegaly 17.54 11.32 18 214944 20736 79508690
Palpitations 17.53 11.32 238 214724 126372 79403054
Prescribed underdose 17.52 11.32 33 214929 29481 79499945
Degenerative bone disease 17.49 11.32 8 214954 120 79529306
Mucosal pain 17.46 11.32 5 214957 16 79529410
Dental paraesthesia 17.45 11.32 4 214958 3 79529423
Diverticulitis 17.39 11.32 195 214767 45741 79483685
COVID-19 pneumonia 17.36 11.32 32 214930 28817 79500609
Skin necrosis 17.29 11.32 14 214948 18073 79511353
Colitis 17.27 11.32 121 214841 73186 79456240
Vertebral wedging 17.23 11.32 5 214957 17 79529409
Dental cyst 17.23 11.32 5 214957 17 79529409
Erectile dysfunction 17.21 11.32 9 214953 14655 79514771
Disease progression 17.16 11.32 633 214329 183729 79345697
Cholecystitis chronic 17.15 11.32 3 214959 9903 79519523
Metastases to peritoneum 17.12 11.32 37 214925 4335 79525091
Electrolyte imbalance 17.07 11.32 36 214926 30845 79498581
Thyroid mass 17.05 11.32 35 214927 3955 79525471
Hypertension 17.03 11.32 724 214238 330268 79199158
Myelodysplastic syndrome 17.02 11.32 35 214927 30266 79499160
Nail avulsion 16.97 11.32 8 214954 129 79529297
Aplastic anaemia 16.94 11.32 14 214948 17891 79511535
Allergy to plants 16.93 11.32 15 214947 744 79528682
Hypercalciuria 16.92 11.32 13 214949 527 79528899
Brain injury 16.92 11.32 5 214957 11512 79517914
Hypercalcaemic nephropathy 16.91 11.32 4 214958 4 79529422
Atrial flutter 16.90 11.32 20 214942 21605 79507821
Cerebral haemorrhage 16.83 11.32 89 214873 57584 79471842
Blood pressure abnormal 16.81 11.32 91 214871 17078 79512348
Pulmonary alveolar haemorrhage 16.78 11.32 5 214957 11452 79517974
Burning sensation 16.68 11.32 236 214726 58396 79471030
Giant cell arteritis 16.62 11.32 28 214934 2723 79526703
VIth nerve paresis 16.54 11.32 8 214954 137 79529289
Spinal disorder 16.53 11.32 63 214899 10197 79519229
Duodenal ulcer 16.50 11.32 12 214950 16357 79513069
Macule 16.43 11.32 29 214933 2928 79526498
Parathyroid gland operation 16.41 11.32 5 214957 21 79529405
Neoplasm 16.39 11.32 58 214904 9058 79520368
Diabetes mellitus inadequate control 16.37 11.32 25 214937 24239 79505187
Osteocalcin decreased 16.35 11.32 6 214956 49 79529377
Pericoronitis 16.35 11.32 6 214956 49 79529377
Extraskeletal ossification 16.34 11.32 7 214955 89 79529337
Epilepsy 16.27 11.32 56 214906 40804 79488622
Abdominal pain upper 16.25 11.32 469 214493 223350 79306076
Oral mucosal erythema 16.21 11.32 23 214939 1927 79527499
Treatment noncompliance 16.20 11.32 79 214883 52189 79477237
Spondylolisthesis 16.19 11.32 30 214932 3145 79526281
Gamma-glutamyltransferase increased 16.17 11.32 84 214878 54596 79474830
Bronchiectasis 16.15 11.32 22 214940 22364 79507062
Myopathy 16.09 11.32 19 214943 20544 79508882
Thyroid calcification 16.03 11.32 4 214958 6 79529420
Carbohydrate antigen 15-3 16.00 11.32 7 214955 94 79529332
Blood uric acid increased 15.98 11.32 8 214954 13352 79516074
Hyperammonaemia 15.96 11.32 5 214957 11088 79518338
Wisdom teeth removal 15.91 11.32 12 214950 473 79528953
Vertigo 15.80 11.32 268 214694 68814 79460612
Blood creatinine abnormal 15.79 11.32 38 214924 4779 79524647
Fibromyalgia 15.75 11.32 105 214857 64235 79465191
Atrioventricular block complete 15.70 11.32 13 214949 16597 79512829
Hepatotoxicity 15.69 11.32 78 214884 51274 79478152
Drug eruption 15.67 11.32 63 214899 43872 79485554
Metastases to soft tissue 15.54 11.32 13 214949 596 79528830
Rhinalgia 15.52 11.32 25 214937 2342 79527084
Therapeutic response shortened 15.51 11.32 12 214950 15851 79513575
Neurotoxicity 15.51 11.32 41 214921 32477 79496949
Tuberculosis 15.51 11.32 11 214951 15187 79514239
Proteinuria 15.49 11.32 41 214921 32461 79496965
Fibula fracture 15.44 11.32 32 214930 3642 79525784
Eosinophil count increased 15.42 11.32 14 214948 17091 79512335
Panniculitis 15.42 11.32 7 214955 12364 79517062
Sense of oppression 15.33 11.32 20 214942 1546 79527880
Vertebral lesion 15.32 11.32 13 214949 608 79528818
Gingival discolouration 15.31 11.32 9 214953 232 79529194
Periprosthetic fracture 15.27 11.32 13 214949 611 79528815
Skin sensitisation 15.26 11.32 16 214946 979 79528447
Mitral valve incompetence 15.21 11.32 34 214928 28531 79500895
Sleep apnoea syndrome 15.21 11.32 49 214913 36429 79492997
Lung infiltration 15.08 11.32 24 214938 22888 79506538
Sputum discoloured 15.06 11.32 22 214940 21721 79507705
Upper respiratory tract infection 15.04 11.32 165 214797 91003 79438423
Toxic encephalopathy 15.02 11.32 6 214956 11434 79517992
Blood glucose decreased 15.00 11.32 30 214932 26204 79503222
Liver disorder 14.95 11.32 124 214838 72293 79457133
Bradyphrenia 14.95 11.32 5 214957 10635 79518791
Hyperbilirubinaemia 14.93 11.32 27 214935 24491 79504935
Tumour lysis syndrome 14.90 11.32 26 214936 23913 79505513
Hypercapnia 14.84 11.32 3 214959 8932 79520494
Diabetic endorgan damage 14.76 11.32 3 214959 0 79529426
Periodontal operation 14.76 11.32 3 214959 0 79529426
Sinus perforation 14.76 11.32 3 214959 0 79529426
Chronic leukaemia 14.69 11.32 4 214958 10 79529416
Metastases to chest wall 14.67 11.32 12 214950 533 79528893
Encephalitis 14.65 11.32 11 214951 14749 79514677
Osteomalacia 14.65 11.32 19 214943 1461 79527965
Ventricular arrhythmia 14.61 11.32 3 214959 8837 79520589
Cataract 14.58 11.32 242 214720 61878 79467548
Device malfunction 14.56 11.32 22 214940 21426 79508000
Catheter site injury 14.55 11.32 9 214953 255 79529171
Pelvic pain 14.54 11.32 73 214889 13308 79516118
Mental disorder 14.53 11.32 40 214922 31262 79498164
Lip exfoliation 14.50 11.32 13 214949 655 79528771
Clostridium difficile colitis 14.43 11.32 42 214920 32241 79497185
Diarrhoea 14.43 11.32 2118 212844 878371 78651055
Immune thrombocytopenia 14.42 11.32 16 214946 17789 79511637
Intramedullary rod insertion 14.42 11.32 8 214954 184 79529242
Fibroblast growth factor 23 increased 14.42 11.32 4 214958 11 79529415
Catatonia 14.42 11.32 3 214959 8753 79520673
Amnesia 14.41 11.32 105 214857 62952 79466474
Hypocalcaemic seizure 14.39 11.32 6 214956 71 79529355
Plantar fasciitis 14.38 11.32 30 214932 3430 79525996
Breast pain 14.36 11.32 52 214910 8213 79521213
Sternal fracture 14.30 11.32 25 214937 2505 79526921
Blood pressure systolic decreased 14.23 11.32 6 214956 11070 79518356
Inflammation 14.17 11.32 173 214789 93580 79435846
Carbohydrate antigen 19-9 increased 14.15 11.32 11 214951 454 79528972
Vision blurred 13.97 11.32 201 214761 105697 79423729
Vipoma 13.92 11.32 4 214958 13 79529413
Vascular fragility 13.92 11.32 7 214955 131 79529295
Febrile bone marrow aplasia 13.85 11.32 9 214953 13011 79516415
Therapy interrupted 13.85 11.32 41 214921 31300 79498126
Malpositioned teeth 13.83 11.32 5 214957 39 79529387
Troponin increased 13.81 11.32 19 214943 19236 79510190
Cholestasis 13.81 11.32 83 214879 52026 79477400
Invasive lobular breast carcinoma 13.80 11.32 13 214949 698 79528728
Malocclusion 13.77 11.32 7 214955 134 79529292
Atrophic vulvovaginitis 13.76 11.32 17 214945 1244 79528182
Speech disorder 13.76 11.32 88 214874 54357 79475069
Surgery 13.75 11.32 142 214820 32624 79496802
Hypovolaemic shock 13.73 11.32 8 214954 12268 79517158
Hypoaesthesia teeth 13.72 11.32 5 214957 40 79529386
Tenosynovitis 13.71 11.32 13 214949 15541 79513885
Blood culture positive 13.65 11.32 3 214959 8426 79521000
Fistula 13.64 11.32 70 214892 12870 79516556
Blood phosphorus abnormal 13.63 11.32 9 214953 286 79529140
Osteosarcoma 13.62 11.32 10 214952 378 79529048
Neuropathy peripheral 13.59 11.32 487 214475 140818 79388608
Ankylosing spondylitis 13.59 11.32 8 214954 12197 79517229
Fear 13.57 11.32 24 214938 21962 79507464
Electrocardiogram ST segment elevation 13.57 11.32 3 214959 8394 79521032
Hypotonia 13.55 11.32 9 214953 12861 79516565
Extradural neoplasm 13.48 11.32 4 214958 15 79529411
Exposure to toxic agent 13.41 11.32 4 214958 9154 79520272
Parkinsonism 13.33 11.32 15 214947 16569 79512857
Hepatic necrosis 13.28 11.32 4 214958 9096 79520330
Skin disorder 13.27 11.32 145 214817 33798 79495628
Atrioventricular block 13.26 11.32 11 214951 14030 79515396
Urine abnormality 13.16 11.32 3 214959 8216 79521210
Product administration error 13.12 11.32 43 214919 31803 79497623
Ocular hyperaemia 13.12 11.32 36 214926 28170 79501256
Bacterial sepsis 13.11 11.32 3 214959 8195 79521231
Metastases to vagina 13.09 11.32 4 214958 17 79529409
Osteoporosis postmenopausal 13.09 11.32 4 214958 17 79529409
Affect lability 13.08 11.32 7 214955 11252 79518174
High turnover osteopathy 13.01 11.32 5 214957 47 79529379
Carcinoembryonic antigen 13.00 11.32 6 214956 92 79529334
Vulvovaginal rash 13.00 11.32 6 214956 92 79529334
Product monitoring error 12.84 11.32 4 214958 8902 79520524
International normalised ratio decreased 12.81 11.32 3 214959 8067 79521359
Generalised oedema 12.81 11.32 28 214934 23681 79505745
Mouth ulceration 12.77 11.32 159 214803 38235 79491191
Pulmonary tumour thrombotic microangiopathy 12.77 11.32 6 214956 96 79529330
BRCA2 gene mutation 12.77 11.32 6 214956 96 79529330
Skin haemorrhage 12.76 11.32 65 214897 11916 79517510
Cardiomegaly 12.74 11.32 33 214929 26319 79503107
General physical health deterioration 12.73 11.32 609 214353 274629 79254797
Metastases to pituitary gland 12.73 11.32 4 214958 19 79529407
Demyelination 12.70 11.32 3 214959 8020 79521406
Tachyphylaxis 12.69 11.32 9 214953 322 79529104
Post procedural haemorrhage 12.69 11.32 11 214951 13733 79515693
Parathyroid hormone-related protein increased 12.69 11.32 3 214959 3 79529423
Injection site haemorrhage 12.65 11.32 36 214926 27834 79501592
Blood magnesium decreased 12.62 11.32 82 214880 16430 79512996
Anaphylactic shock 12.60 11.32 52 214910 35944 79493482
Conjunctivitis 12.59 11.32 32 214930 25683 79503743
Appendicitis 12.57 11.32 23 214939 20771 79508655
Chronic sinusitis 12.56 11.32 10 214952 13016 79516410
Rhinovirus infection 12.54 11.32 3 214959 7950 79521476
Cerebral haematoma 12.51 11.32 3 214959 7939 79521487
Leukoencephalopathy 12.48 11.32 3 214959 7926 79521500
Eastern Cooperative Oncology Group performance status worsened 12.45 11.32 21 214941 2044 79527382
Acute pulmonary oedema 12.42 11.32 12 214950 14218 79515208
Mood altered 12.42 11.32 18 214944 17829 79511597
Nail disorder 12.42 11.32 64 214898 11788 79517638
Bone cancer metastatic 12.41 11.32 8 214954 244 79529182
Deformity thorax 12.40 11.32 4 214958 21 79529405
Drug tolerance 12.32 11.32 4 214958 8671 79520755
Carbohydrate antigen 27.29 increased 12.32 11.32 5 214957 55 79529371
Staphylococcal bacteraemia 12.26 11.32 9 214953 12209 79517217
Respiratory syncytial virus infection 12.23 11.32 5 214957 9397 79520029
Gingival cyst 12.23 11.32 3 214959 4 79529422
Cementoplasty 12.23 11.32 3 214959 4 79529422
Dermatitis exfoliative 12.20 11.32 7 214955 10822 79518604
Cholecystitis 12.19 11.32 26 214936 22186 79507240
Urine calcium increased 12.19 11.32 6 214956 107 79529319
Body temperature increased 12.17 11.32 70 214892 44350 79485076
Bladder disorder 12.16 11.32 53 214909 9112 79520314
Medical device removal 12.16 11.32 12 214950 683 79528743
Catheter site bruise 12.15 11.32 10 214952 448 79528978
Sexual dysfunction 12.10 11.32 3 214959 7760 79521666
Prostatic specific antigen abnormal 12.10 11.32 10 214952 451 79528975
Cervical vertebral fracture 12.04 11.32 29 214933 3649 79525777
Skin plaque 12.03 11.32 7 214955 10738 79518688
Euphoric mood 12.01 11.32 3 214959 7723 79521703
Fatigue 12.01 11.32 2754 212208 926973 78602453
Muscle rigidity 12.01 11.32 22 214940 19860 79509566
Colonoscopy 12.01 11.32 20 214942 1927 79527499
Injected limb mobility decreased 11.96 11.32 4 214958 24 79529402
Chromaturia 11.87 11.32 33 214929 25713 79503713
Spinal cord compression 11.83 11.32 41 214921 6336 79523090
Intervertebral disc degeneration 11.82 11.32 78 214884 15707 79513719
Ileus 11.79 11.32 34 214928 26177 79503249
Jaundice cholestatic 11.73 11.32 8 214954 11276 79518150
Psychomotor hyperactivity 11.72 11.32 17 214945 16832 79512594
Laryngitis viral 11.71 11.32 5 214957 63 79529363
Pneumonia viral 11.70 11.32 5 214957 9153 79520273
Metastatic neoplasm 11.70 11.32 35 214927 5007 79524419
Enterococcal infection 11.70 11.32 15 214947 15645 79513781
Tooth discolouration 11.68 11.32 15 214947 1142 79528284
Bone operation 11.67 11.32 8 214954 271 79529155
Gastroenteritis radiation 11.66 11.32 12 214950 718 79528708
Lumbar spinal stenosis 11.63 11.32 36 214926 5246 79524180
Amylase increased 11.59 11.32 8 214954 11201 79518225
Ear disorder 11.52 11.32 30 214932 3963 79525463
Hydrocalyx 11.48 11.32 3 214959 6 79529420
Dental alveolar anomaly 11.43 11.32 4 214958 28 79529398
Lymphopenia 11.42 11.32 43 214919 30514 79498912
Naevus haemorrhage 11.35 11.32 6 214956 125 79529301
Visual acuity reduced 11.32 11.32 41 214921 29428 79499998
Major depression 11.32 11.32 5 214957 8975 79520451
Nail growth abnormal 11.32 11.32 10 214952 494 79528932

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M05BX04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Other drugs affecting bone structure and mineralization
MeSH PA D050071 Bone Density Conservation Agents
FDA MoA N0000187054 RANK Ligand Blocking Activity
FDA EPC N0000187055 RANK Ligand Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Drug-induced osteoporosis indication 14651005
Osteoporosis indication 64859006 DOID:11476
Postmenopausal osteoporosis indication 102447009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tumor necrosis factor ligand superfamily member 11 Cytokine ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
D03684 KEGG_DRUG
4030131 VUID
N0000181718 NUI
4030131 VANDF
CHEMBL1237023 ChEMBL_ID
6886 IUPHAR_LIGAND_ID
DB06643 DRUGBANK_ID
993449 RXNORM
173191 MMSL
27218 MMSL
d07640 MMSL
013441 NDDF
446321003 SNOMEDCT_US
446457007 SNOMEDCT_US
C1690432 UMLSCUI
D000069448 MESH_DESCRIPTOR_UI
8653 INN_ID
4EQZ6YO2HI UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Prolia HUMAN PRESCRIPTION DRUG LABEL 1 55513-710 INJECTION 60 mg SUBCUTANEOUS BLA 34 sections
Prolia HUMAN PRESCRIPTION DRUG LABEL 1 55513-710 INJECTION 60 mg SUBCUTANEOUS BLA 34 sections
Prolia HUMAN PRESCRIPTION DRUG LABEL 1 55513-710 INJECTION 60 mg SUBCUTANEOUS BLA 34 sections
XGEVA HUMAN PRESCRIPTION DRUG LABEL 1 55513-730 INJECTION 120 mg SUBCUTANEOUS BLA 29 sections
XGEVA HUMAN PRESCRIPTION DRUG LABEL 1 55513-730 INJECTION 120 mg SUBCUTANEOUS BLA 29 sections
XGEVA HUMAN PRESCRIPTION DRUG LABEL 1 55513-730 INJECTION 120 mg SUBCUTANEOUS BLA 29 sections