All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

denosumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
human origin	4965	615258-40-7

Description:

Molecule	Description
Synonyms: denosumab prolia AMG 162 AMG162	A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
0.33	mg	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
May 26, 2010	EMA	Amgen Europe B.V.
June 1, 2010	FDA	AMGEN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	48997.36	11.45	27249	174636	447177	49956062
Osteonecrosis of jaw	9928.87	11.45	4014	197871	28512	50374727
Death	5539.68	11.45	6623	195262	318756	50084483
Spinal fracture	2247.79	11.45	1142	200743	14431	50388808
Bone pain	1941.21	11.45	1565	200320	45664	50357575
Tooth disorder	1774.93	11.45	1141	200744	23087	50380152
Hypocalcaemia	1721.80	11.45	1163	200722	25653	50377586
Pain in jaw	1386.16	11.45	1181	200704	37247	50365992
Drug ineffective	1365.04	11.45	795	201090	818538	49584701
Atypical femur fracture	1327.29	11.45	557	201328	4359	50398880
Tooth extraction	1235.38	11.45	640	201245	8435	50394804
Back pain	1151.40	11.45	2639	199246	217391	50185848
Pain in extremity	1043.26	11.45	2905	198980	269960	50133279
Myalgia	937.46	11.45	1735	200150	122584	50280655
Bone density abnormal	772.04	11.45	330	201555	2715	50400524
Occupational exposure to product	767.79	11.45	284	201601	1516	50401723
Tooth fracture	717.50	11.45	459	201426	9192	50394047
Bone density decreased	704.90	11.45	478	201407	10597	50392642
Accidental exposure to product	688.41	11.45	637	201248	22420	50380819
Fracture	682.78	11.45	554	201331	16279	50386960
Rebound effect	654.74	11.45	298	201587	2891	50400348
Thoracic vertebral fracture	650.17	11.45	320	201565	3753	50399486
Arthralgia	642.62	11.45	3441	198444	435261	49967978
Toothache	579.92	11.45	505	201380	16389	50386850
Toxicity to various agents	575.66	11.45	82	201803	212417	50190822
Lumbar vertebral fracture	565.36	11.45	303	201582	4294	50398945
Maternal exposure during pregnancy	516.65	11.45	30	201855	159748	50243491
Metastases to bone	511.85	11.45	484	201401	17511	50385728
Completed suicide	508.34	11.45	3	201882	131886	50271353
Spinal compression fracture	484.89	11.45	403	201482	12253	50390986
Dental implantation	482.58	11.45	153	201732	459	50402780
Blood parathyroid hormone increased	475.83	11.45	231	201654	2623	50400616
Jaw disorder	474.83	11.45	277	201608	4666	50398573
Exposed bone in jaw	473.97	11.45	229	201656	2571	50400668
Dental care	468.38	11.45	166	201719	766	50402473
Exposure during pregnancy	460.18	11.45	4	201881	121011	50282228
Groin pain	457.42	11.45	337	201548	8554	50394685
Drug intolerance	447.10	11.45	158	201727	218946	50184293
Tooth loss	442.70	11.45	287	201598	5883	50397356
Pemphigus	435.16	11.45	9	201876	120157	50283082
Hip fracture	428.41	11.45	523	201362	25408	50377831
Drug interaction	424.64	11.45	134	201751	199487	50203752
Infusion related reaction	424.40	11.45	81	201804	169476	50233763
Femur fracture	423.53	11.45	628	201257	36836	50366403
Contraindicated product administered	413.88	11.45	53	201832	148905	50254334
Treatment failure	399.77	11.45	42	201843	137595	50265644
Synovitis	398.10	11.45	24	201861	123841	50279398
Pathological fracture	392.55	11.45	290	201595	7392	50395847
Condition aggravated	382.54	11.45	373	201512	296685	50106554
Musculoskeletal pain	378.55	11.45	868	201017	71309	50331930
Systemic lupus erythematosus	360.86	11.45	63	201822	140559	50262680
Terminal state	346.41	11.45	169	201716	1941	50401298
Drug hypersensitivity	343.43	11.45	298	201587	250712	50152527
Bone loss	342.33	11.45	181	201704	2491	50400748
Product use issue	327.44	11.45	95	201790	149380	50253859
Breast cancer metastatic	314.44	11.45	289	201596	10075	50393164
Loose tooth	309.19	11.45	181	201704	3069	50400170
Acute kidney injury	298.48	11.45	282	201603	227776	50175463
Joint swelling	285.48	11.45	335	201550	244951	50158288
Glossodynia	285.30	11.45	57	201828	115512	50287727
Hypotension	284.47	11.45	312	201573	235157	50168082
Exostosis of jaw	282.49	11.45	124	201761	1095	50402144
Therapeutic product effect decreased	279.22	11.45	97	201788	135953	50267286
Hepatic enzyme increased	275.06	11.45	102	201783	137278	50265961
Incorrect route of product administration	274.09	11.45	355	201530	18311	50384928
Vomiting	272.48	11.45	936	200949	459822	49943417
Hospitalisation	257.93	11.45	723	201162	67214	50336025
Blood calcium decreased	255.68	11.45	362	201523	20344	50382895
Hand deformity	254.59	11.45	46	201839	100153	50303086
Dental caries	249.78	11.45	249	201636	9618	50393621
Osteomyelitis	243	11.45	368	201517	21985	50381254
Overdose	240.34	11.45	52	201833	99675	50303564
Metastases to liver	240.19	11.45	346	201539	19758	50383481
Intentional overdose	233.24	11.45	3	201882	62501	50340738
Product use in unapproved indication	228.46	11.45	88	201797	115731	50287508
Somnolence	228.01	11.45	171	201714	154814	50248425
Atypical fracture	224.56	11.45	86	201799	513	50402726
Drug abuse	222.76	11.45	3	201882	59843	50343396
Abdominal discomfort	221.76	11.45	364	201521	231277	50171962
Pericarditis	216.05	11.45	29	201856	78660	50324579
Foot fracture	214.49	11.45	328	201557	19763	50383476
Wound	210.97	11.45	79	201806	105715	50297524
Neoplasm progression	210.57	11.45	400	201485	28757	50374482
Rheumatoid arthritis	209.46	11.45	302	201583	202248	50200991
Eczema	204.48	11.45	343	201542	22359	50380880
Investigation	204.13	11.45	107	201778	1445	50401794
Dyspnoea	204.02	11.45	1315	200570	546293	49856946
Mobility decreased	202.19	11.45	740	201145	79208	50324031
Blood calcium increased	201.33	11.45	198	201687	7521	50395718
Confusional state	199.44	11.45	270	201615	185658	50217581
Product storage error	197.73	11.45	244	201641	11980	50391259
Bone disorder	197.17	11.45	304	201581	18448	50384791
Endodontic procedure	190.30	11.45	125	201760	2621	50400618
Swelling	189.10	11.45	319	201566	200553	50202686
Muscle spasms	188.05	11.45	993	200892	124560	50278679
Compression fracture	185.35	11.45	167	201718	5670	50397569
Nausea	184.98	11.45	1863	200022	703535	49699704
Jaw operation	179.63	11.45	79	201806	701	50402538
Rheumatoid factor positive	179.38	11.45	4	201881	49855	50353384
Multiple fractures	176.95	11.45	172	201713	6439	50396800
Weight increased	171.88	11.45	341	201544	201550	50201689
Gingival pain	169.71	11.45	161	201724	5845	50397394
Headache	167.04	11.45	1260	200625	505275	49897964
Temporomandibular joint syndrome	166.13	11.45	127	201758	3412	50399827
Helicobacter infection	164.69	11.45	8	201877	49694	50353545
Tooth abscess	163.46	11.45	228	201657	12632	50390607
Seizure	160.89	11.45	140	201745	117734	50285505
Suicide attempt	160.34	11.45	12	201873	51720	50351519
Blood calcium abnormal	157.62	11.45	80	201805	1006	50402233
Gingival disorder	157.05	11.45	118	201767	3087	50400152
Duodenal ulcer perforation	155.57	11.45	6	201879	45605	50357634
Malignant neoplasm progression	154.43	11.45	609	201276	67515	50335724
Bradycardia	154.37	11.45	34	201851	64392	50338847
Cardiac arrest	153.01	11.45	71	201814	83580	50319659
Osteonecrosis	150.49	11.45	299	201586	22218	50381021
Tooth infection	148.67	11.45	229	201656	13883	50389356
Intentional product use issue	145.85	11.45	62	201823	76856	50326383
Wrist fracture	145.02	11.45	203	201682	11284	50391955
Pyrexia	144.33	11.45	907	200978	379296	50023943
Artificial crown procedure	143.52	11.45	50	201835	217	50403022
Dental operation	142.74	11.45	75	201810	1018	50402221
Pneumonia	142.45	11.45	905	200980	377496	50025743
Abortion spontaneous	137.52	11.45	7	201878	41765	50361474
Pelvic fracture	135.74	11.45	197	201688	11323	50391916
Gingivitis	135.26	11.45	156	201729	7128	50396111
Spinal pain	133.55	11.45	189	201696	10614	50392625
Cystitis	133.07	11.45	436	201449	44128	50359111
Tetany	132.76	11.45	82	201803	1539	50401700
Coma	132.33	11.45	32	201853	56847	50346392
Hyperaesthesia teeth	132.16	11.45	80	201805	1446	50401793
Gingival recession	130.88	11.45	75	201810	1219	50402020
Hypersensitivity	130.21	11.45	432	201453	214729	50188510
Sinusitis	129.44	11.45	307	201578	170251	50232988
Abdominal pain	128.54	11.45	496	201389	235732	50167507
Tachycardia	128.42	11.45	125	201760	99638	50303601
Bedridden	128.00	11.45	172	201713	9195	50394044
Suicidal ideation	127.21	11.45	32	201853	55353	50347886
Dental restoration failure	125.23	11.45	56	201829	519	50402720
Cardio-respiratory arrest	124.05	11.45	31	201854	53861	50349378
Depressed level of consciousness	123.29	11.45	28	201857	51925	50351314
Folliculitis	121.84	11.45	9	201876	39216	50364023
Oxygen saturation decreased	120.89	11.45	71	201814	73177	50330062
Muscle injury	119.74	11.45	7	201878	37104	50366135
Stress fracture	118.95	11.45	142	201743	6733	50396506
Hyponatraemia	118.56	11.45	125	201760	96014	50307225
Abscess jaw	117.11	11.45	71	201814	1287	50401952
Lower limb fracture	116.17	11.45	206	201679	14040	50389199
Lactic acidosis	115.09	11.45	4	201881	33351	50369888
Inappropriate schedule of product administration	112.90	11.45	576	201309	71255	50331984
Breast cancer	110.91	11.45	400	201485	42490	50360749
Respiratory failure	110.83	11.45	120	201765	91061	50312178
Gingival swelling	109.65	11.45	103	201782	3692	50399547
Febrile neutropenia	109.60	11.45	137	201748	97530	50305709
Rib fracture	109.45	11.45	239	201646	18982	50384257
Multiple sclerosis relapse	108.49	11.45	20	201865	42944	50360295
Lower respiratory tract infection	108.45	11.45	132	201753	95069	50308170
Metastases to lung	108.00	11.45	173	201712	10847	50392392
Hypoglycaemia	105.13	11.45	41	201844	53540	50349699
Periodontitis	103.79	11.45	91	201794	2978	50400261
Agitation	102.86	11.45	42	201843	53342	50349897
Psoriatic arthropathy	100.88	11.45	31	201854	47001	50356238
Musculoskeletal discomfort	97.36	11.45	196	201689	14702	50388537
Dehydration	97.12	11.45	299	201586	152150	50251089
International normalised ratio increased	97.06	11.45	26	201859	43126	50360113
Vitamin D decreased	96.50	11.45	142	201743	8264	50394975
Syncope	95.51	11.45	165	201720	102837	50300402
Diarrhoea	95.15	11.45	1715	200170	586761	49816478
Body height decreased	94.46	11.45	145	201740	8763	50394476
Rash pruritic	92.93	11.45	408	201477	47438	50355801
Unresponsive to stimuli	92.34	11.45	8	201877	30601	50372638
C-telopeptide increased	92.11	11.45	22	201863	9	50403230
Tumour marker increased	91.87	11.45	94	201791	3746	50399493
Osteitis	91.42	11.45	84	201801	2926	50400313
Dermatitis	91.36	11.45	186	201699	14065	50389174
Metabolic acidosis	88.07	11.45	23	201862	38802	50364437
Mastication disorder	87.86	11.45	67	201818	1793	50401446
Neoplasm malignant	87.60	11.45	250	201635	23465	50379774
Infection	87.19	11.45	374	201511	172580	50230659
Sequestrectomy	87.13	11.45	49	201836	767	50402472
Anaphylactic reaction	86.94	11.45	54	201831	54001	50349238
Osteoporotic fracture	86.38	11.45	83	201802	3062	50400177
Gastrointestinal haemorrhage	86.35	11.45	99	201786	73222	50330017
Serotonin syndrome	85.14	11.45	3	201882	24710	50378529
Influenza like illness	84.92	11.45	453	201432	57006	50346233
Hypoxia	83.72	11.45	50	201835	51073	50352166
Upper limb fracture	82.13	11.45	190	201695	15683	50387556
Blood pressure decreased	81.73	11.45	62	201823	55847	50347392
Dental cleaning	81.64	11.45	21	201864	19	50403220
Loss of consciousness	81.39	11.45	185	201700	104168	50299071
Multiple organ dysfunction syndrome	81.35	11.45	50	201835	50287	50352952
Hypercalcaemia	81.28	11.45	241	201644	23111	50380128
Fall	81.06	11.45	1826	200059	333106	50070133
Encephalopathy	80.32	11.45	18	201867	33693	50369546
Respiratory arrest	80.14	11.45	12	201873	29997	50373242
Arthropathy	79.87	11.45	341	201544	157565	50245674
No adverse event	79.86	11.45	18	201867	33560	50369679
Sleep disorder due to a general medical condition	79.59	11.45	121	201764	7250	50395989
C-reactive protein abnormal	79.36	11.45	9	201876	27800	50375439
Osteonecrosis of external auditory canal	79.09	11.45	25	201860	74	50403165
Intentional self-injury	78.95	11.45	3	201882	23109	50380130
Alanine aminotransferase increased	78.80	11.45	145	201740	88214	50315025
Chest discomfort	78.47	11.45	157	201728	92565	50310674
Nasopharyngitis	77.33	11.45	452	201433	192475	50210764
Wheezing	77.24	11.45	80	201805	61967	50341272
Metastases to lymph nodes	76.83	11.45	116	201769	6908	50396331
Dry skin	76.18	11.45	358	201527	42833	50360406
Anxiety	76.13	11.45	407	201478	177199	50226040
Foetal exposure during pregnancy	75.27	11.45	10	201875	27349	50375890
Carbohydrate antigen 15-3 increased	74.74	11.45	50	201835	1082	50402157
Hyperparathyroidism	74.55	11.45	68	201817	2346	50400893
Irritable bowel syndrome	73.98	11.45	58	201827	51383	50351856
Metastases to spine	72.68	11.45	72	201813	2759	50400480
Joint noise	72.01	11.45	80	201805	3507	50399732
Chest pain	71.63	11.45	413	201472	176469	50226770
Discomfort	71.56	11.45	209	201676	108171	50295068
Injection site erythema	71.34	11.45	118	201767	74818	50328421
Type 2 diabetes mellitus	71.34	11.45	24	201861	34351	50368888
Gingival abscess	71.19	11.45	41	201844	673	50402566
Tooth erosion	70.68	11.45	35	201850	416	50402823
Mental status changes	69.12	11.45	29	201856	36243	50366996
Incorrect dose administered	69.11	11.45	55	201830	48359	50354880
PIK3CA-activated mutation	68.95	11.45	42	201843	768	50402471
Hyperkalaemia	68.18	11.45	55	201830	48034	50355205
Renal failure	67.98	11.45	209	201676	106424	50296815
Pancytopenia	67.96	11.45	146	201739	83884	50319355
Sedation	67.79	11.45	19	201866	30591	50372648
Drug withdrawal syndrome	67.05	11.45	10	201875	25071	50378168
Dental necrosis	66.15	11.45	24	201861	120	50403119
Aspartate aminotransferase increased	66.05	11.45	132	201753	77866	50325373
Oedema	65.43	11.45	112	201773	70069	50333170
Flushing	65.22	11.45	104	201781	66911	50336328
Oedema peripheral	64.39	11.45	368	201517	157593	50245646
Premature delivery	64.27	11.45	9	201876	23654	50379585
Sepsis	64.21	11.45	292	201593	132633	50270606
Drug reaction with eosinophilia and systemic symptoms	64.16	11.45	17	201868	28407	50374832
Fatigue	64.04	11.45	2247	199638	705354	49697885
Jaw fistula	63.74	11.45	19	201866	43	50403196
Heart rate decreased	63.65	11.45	33	201852	36464	50366775
Blood parathyroid hormone abnormal	63.56	11.45	26	201859	189	50403050
Product quality issue	63.25	11.45	22	201863	30836	50372403
Emotional distress	63.09	11.45	18	201867	28645	50374594
Fractured sacrum	62.19	11.45	54	201831	1744	50401495
Tremor	61.92	11.45	242	201643	114661	50288578
Delirium	61.63	11.45	38	201847	38154	50365085
Peripheral swelling	61.23	11.45	526	201359	205410	50197829
Blood pressure increased	61.04	11.45	298	201587	132834	50270405
Therapeutic response decreased	60.96	11.45	59	201826	47172	50356067
Psoriasis	60.84	11.45	114	201771	68886	50334353
Sinus tachycardia	60.71	11.45	7	201878	21347	50381892
Metastases to central nervous system	60.53	11.45	137	201748	11145	50392094
Asthma	59.91	11.45	171	201714	89166	50314073
Toxic epidermal necrolysis	59.39	11.45	7	201878	20985	50382254
Femoral neck fracture	59.39	11.45	107	201778	7383	50395856
Rhabdomyolysis	58.70	11.45	42	201843	38985	50364254
Hospice care	58.47	11.45	92	201793	5680	50397559
Vitamin D abnormal	58.33	11.45	22	201863	125	50403114
Migraine	58.25	11.45	134	201751	75146	50328093
Hallucination	58.25	11.45	60	201825	46597	50356642
Drug level increased	58.22	11.45	5	201880	19263	50383976
Cardiac failure congestive	57.70	11.45	160	201725	84222	50319017
Injection site reaction	57.35	11.45	69	201816	49963	50353276
Hypophosphataemia	56.54	11.45	112	201773	8302	50394937
Septic shock	56.33	11.45	88	201797	57087	50346152
Immobile	56.04	11.45	84	201801	4970	50398269
Spinal deformity	55.56	11.45	39	201846	915	50402324
Pulpitis dental	55.50	11.45	37	201848	796	50402443
Psychotic disorder	55.40	11.45	10	201875	21802	50381437
Living in residential institution	55.23	11.45	30	201855	437	50402802
Paraesthesia	54.70	11.45	726	201159	119517	50283722
Product dose omission issue	53.77	11.45	1031	200854	182807	50220432
Polymyalgia rheumatica	53.28	11.45	59	201826	2577	50400662
Liver function test abnormal	53.14	11.45	59	201826	44280	50358959
Haemoglobin decreased	53.12	11.45	294	201591	126922	50276317
Tooth resorption	52.85	11.45	16	201869	39	50403200
Dysarthria	52.74	11.45	43	201842	37360	50365879
Orthostatic hypotension	52.39	11.45	26	201859	29455	50373784
Dental discomfort	52.34	11.45	27	201858	352	50402887
Fluid retention	51.78	11.45	76	201809	50573	50352666
Depression	51.20	11.45	418	201467	165005	50238234
Impaired healing	50.99	11.45	463	201422	69323	50333916
Musculoskeletal stiffness	50.92	11.45	302	201583	128179	50275060
C-reactive protein increased	50.89	11.45	119	201766	66355	50336884
Cognitive disorder	50.41	11.45	61	201824	44062	50359177
Dental fistula	50.37	11.45	31	201854	578	50402661
Liver injury	50.30	11.45	18	201867	24788	50378451
Generalised tonic-clonic seizure	50.19	11.45	21	201864	26289	50376950
Sciatica	49.91	11.45	193	201692	21189	50382050
Blood glucose increased	49.69	11.45	134	201751	71190	50332049
Anaemia	49.14	11.45	710	201175	251746	50151493
Tibia fracture	49.08	11.45	74	201811	4401	50398838
Metastases to skin	48.77	11.45	42	201843	1341	50401898
Injury	48.49	11.45	75	201810	48850	50354389
Jaw fracture	48.15	11.45	54	201831	2392	50400847
Muscle spasticity	47.95	11.45	6	201879	17178	50386061
Neck pain	47.66	11.45	390	201495	56677	50346562
Dizziness	47.42	11.45	1037	200848	345332	50057907
Heart rate increased	47.41	11.45	154	201731	77096	50326143
Parathyroidectomy	47.31	11.45	22	201863	225	50403014
Stevens-Johnson syndrome	47.25	11.45	14	201871	21738	50381501
Scoliosis	47.19	11.45	90	201795	6486	50396753
Hyperhidrosis	47.12	11.45	190	201695	89236	50314003
Oral pain	46.73	11.45	211	201674	24822	50378417
Blood phosphorus decreased	46.40	11.45	66	201819	3723	50399516
Humerus fracture	45.98	11.45	97	201788	7521	50395718
Blister	45.95	11.45	180	201705	85238	50318001
Right ventricular failure	45.71	11.45	5	201880	15888	50387351
Menopausal symptoms	45.27	11.45	48	201837	1995	50401244
Injection site pruritus	44.98	11.45	57	201828	40354	50362885
Parathyroid disorder	44.85	11.45	28	201857	536	50402703
Adverse reaction	44.66	11.45	103	201782	8483	50394756
Pulmonary arterial hypertension	44.28	11.45	13	201872	20306	50382933
Traumatic fracture	43.86	11.45	28	201857	558	50402681
Hypervolaemia	43.08	11.45	24	201861	25475	50377764
Device dislocation	43.07	11.45	16	201869	21530	50381709
Gait disturbance	42.73	11.45	838	201047	149167	50254072
White blood cell count increased	42.58	11.45	64	201821	42176	50361063
Red blood cell sedimentation rate increased	42.50	11.45	33	201852	29383	50373856
Drug dependence	42.41	11.45	13	201872	19746	50383493
Eosinophilia	42.39	11.45	11	201874	18641	50384598
Caesarean section	42.35	11.45	6	201879	15633	50387606
Bronchitis	42.24	11.45	243	201642	103916	50299323
Medication error	42.22	11.45	49	201836	36055	50367184
Status epilepticus	41.85	11.45	3	201882	13403	50389836
Product substitution issue	41.52	11.45	4	201881	14053	50389186
Haematemesis	41.48	11.45	30	201855	27695	50375544
Prescribed overdose	40.98	11.45	5	201880	14595	50388644
Hand fracture	40.88	11.45	68	201817	4400	50398839
Drug ineffective for unapproved indication	40.57	11.45	17	201868	21264	50381975
Dental prosthesis placement	40.51	11.45	14	201871	59	50403180
Mouth swelling	40.48	11.45	63	201822	3853	50399386
Oral surgery	40.40	11.45	33	201852	978	50402261
Aggression	40.04	11.45	17	201868	21099	50382140
Parathyroid tumour	39.99	11.45	16	201869	109	50403130
Haematochezia	39.65	11.45	61	201824	39821	50363418
Osteoporosis	39.26	11.45	310	201575	44569	50358670
Deep vein thrombosis	39.09	11.45	155	201730	73149	50330090
Device failure	38.86	11.45	75	201810	5453	50397786
Staphylococcal infection	38.85	11.45	51	201834	35565	50367674
Nasal congestion	38.74	11.45	92	201793	51028	50352211
Musculoskeletal chest pain	38.47	11.45	161	201724	18325	50384914
Noninfective gingivitis	38.29	11.45	35	201850	1211	50402028
Cytomegalovirus infection	38.22	11.45	12	201873	17950	50385289
Oral infection	38.16	11.45	63	201822	4051	50399188
Spinal operation	38.12	11.45	80	201805	6180	50397059
Vitamin D deficiency	38.09	11.45	116	201769	11286	50391953
Dyskinesia	38.09	11.45	33	201852	27828	50375411
Blood alkaline phosphatase decreased	37.92	11.45	33	201852	1069	50402170
Infusion site pain	37.86	11.45	3	201882	12343	50390896
Abdominal lymphadenopathy	37.72	11.45	27	201858	654	50402585
Blood pressure fluctuation	37.36	11.45	53	201832	35770	50367469
Coronary artery disease	37.36	11.45	38	201847	29688	50373551
Pulmonary hypertension	37.33	11.45	47	201838	33370	50369869
Irritability	37.27	11.45	35	201850	28391	50374848
Body temperature increased	37.23	11.45	42	201843	31299	50371940
Walking aid user	36.63	11.45	80	201805	6353	50396886
Circulatory collapse	36.51	11.45	17	201868	19983	50383256
Disorientation	36.51	11.45	53	201832	35431	50367808
Oestrogen deficiency	36.28	11.45	16	201869	143	50403096
Bone resorption test abnormal	36.18	11.45	9	201876	6	50403233
Hyperparathyroidism secondary	35.89	11.45	35	201850	1315	50401924
Poisoning	35.52	11.45	4	201881	12425	50390814
Acute respiratory distress syndrome	35.44	11.45	20	201865	21079	50382160
Drug-induced liver injury	35.21	11.45	36	201849	28059	50375180
Hemiparesis	35.14	11.45	18	201867	20030	50383209
Product prescribing error	35.02	11.45	20	201865	20941	50382298
Trismus	34.80	11.45	54	201831	3294	50399945
Abdominal pain upper	34.59	11.45	438	201447	158871	50244368
Cyanosis	34.42	11.45	9	201876	15175	50388064
Hypokalaemia	34.23	11.45	208	201677	87784	50315455
Paraesthesia oral	34.19	11.45	117	201768	12104	50391135
Haematoma	33.99	11.45	43	201842	30467	50372772
Bone lesion	33.75	11.45	68	201817	5102	50398137
Radius fracture	33.69	11.45	52	201833	3157	50400082
Withdrawal syndrome	33.62	11.45	14	201871	17576	50385663
Bronchospasm	33.30	11.45	9	201876	14845	50388394
Pneumonia aspiration	33.20	11.45	45	201840	30959	50372280
Extrapyramidal disorder	33.11	11.45	4	201881	11766	50391473
Hypophosphatasia	33.00	11.45	8	201877	4	50403235
Ventricular tachycardia	32.91	11.45	11	201874	15810	50387429
Lichen planus	32.80	11.45	40	201845	1939	50401300
Blood creatine phosphokinase increased	32.80	11.45	34	201851	26333	50376906
Metastasis	32.79	11.45	61	201824	4314	50398925
Vision blurred	32.68	11.45	182	201703	78465	50324774
Haematocrit decreased	32.43	11.45	56	201829	34920	50368319
Obstructive airways disorder	32.35	11.45	11	201874	15641	50387598
Respiratory distress	31.90	11.45	45	201840	30444	50372795
Immune system disorder	31.69	11.45	88	201797	8129	50395110
Coagulopathy	31.62	11.45	16	201869	17928	50385311
Sinus bradycardia	31.48	11.45	7	201878	13176	50390063
Palpitations	31.46	11.45	234	201651	94272	50308967
Rash papular	31.26	11.45	116	201769	12488	50390751
Pancreatitis	31.26	11.45	78	201807	42536	50360703
Atrial fibrillation	31.04	11.45	258	201627	101487	50301752
Disease recurrence	31.00	11.45	21	201864	20060	50383179
Adverse drug reaction	30.99	11.45	347	201538	54875	50348364
Blood bilirubin increased	30.90	11.45	50	201835	31988	50371251
Bone marrow failure	30.70	11.45	39	201846	27585	50375654
Acute myeloid leukaemia	30.46	11.45	11	201874	15063	50388176
Pancreatitis acute	30.43	11.45	30	201855	23782	50379457
Paranoia	30.42	11.45	3	201882	10345	50392894
Ear pain	30.26	11.45	205	201680	28078	50375161
Oral cavity fistula	30.02	11.45	23	201862	620	50402619
Forearm fracture	29.93	11.45	20	201865	432	50402807
Feeling abnormal	29.87	11.45	683	201202	124809	50278430
Photophobia	29.85	11.45	11	201874	14876	50388363
Abnormal behaviour	29.76	11.45	21	201864	19637	50383602
Intentional product misuse	29.48	11.45	92	201793	46642	50356597
Diabetes mellitus inadequate control	29.40	11.45	8	201877	13137	50390102
Respiratory rate increased	29.39	11.45	5	201880	11380	50391859
Myocardial infarction	29.36	11.45	221	201664	88806	50314433
Tubulointerstitial nephritis	29.24	11.45	12	201873	15199	50388040
Pulmonary oedema	29.03	11.45	99	201786	48839	50354400
Anuria	28.89	11.45	5	201880	11239	50392000
Nightmare	28.86	11.45	14	201871	16072	50387167
Denture wearer	28.85	11.45	15	201870	199	50403040
Tachypnoea	28.84	11.45	11	201874	14566	50388673
Acute respiratory failure	28.63	11.45	44	201841	28738	50374501
Hepatic steatosis	28.61	11.45	33	201852	24351	50378888
Hepatitis	28.58	11.45	51	201834	31402	50371837
Myoclonus	28.50	11.45	11	201874	14459	50388780
Unevaluable event	28.42	11.45	295	201590	45771	50357468
Labelled drug-drug interaction medication error	28.42	11.45	4	201881	10473	50392766
Gingival erythema	28.40	11.45	22	201863	603	50402636
Bacteraemia	28.38	11.45	11	201874	14422	50388817
Upper respiratory tract infection	28.20	11.45	151	201734	65747	50337492
Accidental overdose	28.11	11.45	22	201863	19511	50383728
Cough	28.09	11.45	740	201145	240524	50162715
Blood creatinine increased	28.09	11.45	183	201702	75977	50327262
Thrombocytopenia	28.09	11.45	350	201535	127323	50275916
COVID-19	27.95	11.45	94	201791	46568	50356671
Gingival operation	27.93	11.45	12	201873	100	50403139
Melaena	27.76	11.45	40	201845	26824	50376415
Metastases to pleura	27.73	11.45	30	201855	1276	50401963
Back disorder	27.73	11.45	91	201794	9214	50394025
Vitamin D increased	27.63	11.45	21	201864	559	50402680
Pneumocystis jirovecii pneumonia	27.49	11.45	12	201873	14651	50388588
Periodontal disease	27.47	11.45	32	201853	1478	50401761
Agranulocytosis	27.36	11.45	27	201858	21394	50381845
Diabetic ketoacidosis	27.18	11.45	19	201866	17853	50385386
Rash macular	27.13	11.45	150	201735	19127	50384112
Hallucination, auditory	27.07	11.45	5	201880	10723	50392516
Scab	27.03	11.45	72	201813	6490	50396749
Contusion	26.81	11.45	302	201583	111881	50291358
Bone graft	26.80	11.45	24	201861	808	50402431
Onychoclasis	26.66	11.45	62	201823	5134	50398105
Obesity	26.63	11.45	17	201868	16758	50386481
Palliative care	26.62	11.45	17	201868	339	50402900
Injury associated with device	26.61	11.45	46	201839	3071	50400168
Haemoptysis	26.50	11.45	38	201847	25535	50377704
Cardiogenic shock	25.89	11.45	15	201870	15584	50387655
Intercepted medication error	25.69	11.45	18	201867	421	50402818
Respiratory depression	25.60	11.45	8	201877	12002	50391237
Cataract operation	25.57	11.45	53	201832	4058	50399181
Exostosis	25.44	11.45	103	201782	11550	50391689
Haemorrhage	25.42	11.45	118	201767	53323	50349916
Drug resistance	25.35	11.45	23	201862	18966	50384273
Oral discomfort	25.33	11.45	80	201805	7937	50395302
Angioedema	25.33	11.45	72	201813	37604	50365635
Acidosis	25.31	11.45	5	201880	10222	50393017
Posterior reversible encephalopathy syndrome	25.29	11.45	14	201871	14914	50388325
Renal tubular necrosis	25.10	11.45	5	201880	10163	50393076
Sputum discoloured	25.06	11.45	11	201874	13384	50389855
Injection site bruising	24.91	11.45	70	201815	36698	50366541
Chemotherapy	24.88	11.45	29	201856	1340	50401899
Hepatocellular injury	24.55	11.45	41	201844	25906	50377333
Restlessness	24.55	11.45	39	201846	25134	50378105
Disturbance in attention	24.53	11.45	55	201830	31131	50372108
Bone density increased	24.52	11.45	18	201867	454	50402785
Cholelithiasis	24.49	11.45	74	201811	37899	50365340
Bone swelling	24.31	11.45	27	201858	1183	50402056
Altered state of consciousness	24.28	11.45	31	201854	21879	50381360
Inappropriate antidiuretic hormone secretion	24.26	11.45	11	201874	13132	50390107
Dementia	24.22	11.45	127	201758	15870	50387369
Prescribed underdose	24.20	11.45	17	201868	15932	50387307
Hyperglycaemia	24.16	11.45	70	201815	36335	50366904
Nerve compression	24.08	11.45	75	201810	7387	50395852
Amnesia	24.05	11.45	87	201798	42173	50361066
Renal injury	24.04	11.45	3	201882	8608	50394631
Basal cell carcinoma	23.92	11.45	35	201850	23321	50379918
Hypothermia	23.89	11.45	9	201876	12007	50391232
Malpositioned teeth	23.74	11.45	7	201878	15	50403224
Hypertension	23.74	11.45	651	201234	210552	50192687
Blood creatinine abnormal	23.71	11.45	40	201845	2618	50400621
Therapeutic product effect incomplete	23.62	11.45	242	201643	91273	50311966
Wrong technique in product usage process	23.52	11.45	331	201554	55179	50348060
Sleep disorder due to general medical condition, insomnia type	23.50	11.45	57	201828	31390	50371849
Metaphyseal corner fracture	23.48	11.45	8	201877	32	50403207
Calcinosis	23.37	11.45	33	201852	1849	50401390
Electrocardiogram QT prolonged	23.26	11.45	117	201768	51769	50351470
Ataxia	23.25	11.45	13	201872	13773	50389466
Parathyroid tumour malignant	23.14	11.45	7	201878	17	50403222
Metastases to peritoneum	23.14	11.45	41	201844	2792	50400447
Affect lability	23.12	11.45	4	201881	8994	50394245
Injection site swelling	23.12	11.45	87	201798	41686	50361553
Shock haemorrhagic	23.07	11.45	3	201882	8341	50394898
Pulmonary embolism	23.05	11.45	277	201608	101427	50301812
Gingival cyst	23.03	11.45	6	201879	6	50403233
Device fastener issue	23.03	11.45	6	201879	6	50403233
Bone cancer	23.02	11.45	26	201859	1161	50402078
Leukocytosis	22.96	11.45	34	201851	22545	50380694
Injection site haemorrhage	22.84	11.45	31	201854	21315	50381924
Hypoaesthesia oral	22.76	11.45	94	201791	10634	50392605
Pollakiuria	22.67	11.45	168	201717	23683	50379556
Akathisia	22.65	11.45	3	201882	8226	50395013
Bone metabolism biochemical marker increased	22.64	11.45	5	201880	0	50403239
Orthodontic procedure	22.64	11.45	5	201880	0	50403239
Aphasia	22.62	11.45	50	201835	28444	50374795
Rehabilitation therapy	22.52	11.45	27	201858	1286	50401953
Rales	22.46	11.45	6	201879	9972	50393267
Hip surgery	22.40	11.45	39	201846	2619	50400620
Acute coronary syndrome	22.34	11.45	5	201880	9369	50393870
Osteolysis	22.18	11.45	38	201847	2519	50400720
Vaginal haemorrhage	22.13	11.45	40	201845	24511	50378728
Shock	22.08	11.45	30	201855	20620	50382619
Oral disorder	21.86	11.45	75	201810	7769	50395470
Macule	21.83	11.45	29	201856	1533	50401706
Device malfunction	21.80	11.45	17	201868	15104	50388135
Osteocalcin decreased	21.71	11.45	6	201879	9	50403230
Root canal infection	21.67	11.45	13	201872	231	50403008
Angina pectoris	21.58	11.45	45	201840	26143	50377096
Cholesteatoma	21.56	11.45	11	201874	140	50403099
Amenorrhoea	21.31	11.45	4	201881	8480	50394759
Gingival ulceration	21.28	11.45	21	201864	801	50402438
Ankle fracture	21.24	11.45	121	201764	15601	50387638
Blood glucose decreased	20.99	11.45	25	201860	18186	50385053
Patella fracture	20.97	11.45	31	201854	1811	50401428
Gastroenteritis	20.93	11.45	38	201847	23243	50379996
Delusion	20.87	11.45	8	201877	10561	50392678
Ventricular fibrillation	20.84	11.45	8	201877	10551	50392688
Dysstasia	20.79	11.45	132	201753	17687	50385552
Coordination abnormal	20.75	11.45	10	201875	11524	50391715
Hyperthermia	20.73	11.45	3	201882	7693	50395546
Adrenal insufficiency	20.55	11.45	16	201869	14227	50389012
Cardiac failure	20.48	11.45	199	201686	75841	50327398
Oliguria	20.37	11.45	4	201881	8212	50395027
Generalised oedema	20.35	11.45	15	201870	13716	50389523
Bronchopulmonary aspergillosis	20.35	11.45	3	201882	7589	50395650
Abscess oral	20.35	11.45	26	201859	1322	50401917
Creatinine renal clearance decreased	20.33	11.45	11	201874	11870	50391369
Oral mucosal erythema	20.24	11.45	26	201859	1329	50401910
Skin exfoliation	20.14	11.45	214	201671	33398	50369841
Atelectasis	20.09	11.45	26	201859	18244	50384995
Hepatic failure	20.05	11.45	64	201821	32219	50371020
Carcinoembryonic antigen increased	20.04	11.45	27	201858	1447	50401792
Gastrointestinal disorder	20.00	11.45	261	201624	94195	50309044
Dental prosthesis user	19.94	11.45	8	201877	55	50403184
Musculoskeletal disorder	19.92	11.45	128	201757	17221	50386018
Gestational diabetes	19.90	11.45	3	201882	7462	50395777
Therapy interrupted	19.86	11.45	31	201854	20121	50383118
Kyphosis	19.77	11.45	34	201851	2261	50400978
Acute hepatic failure	19.74	11.45	20	201865	15657	50387582
Sleep apnoea syndrome	19.68	11.45	41	201844	23827	50379412
Weight bearing difficulty	19.67	11.45	34	201851	2270	50400969
Schizophrenia	19.65	11.45	3	201882	7394	50395845
Acute myocardial infarction	19.63	11.45	56	201829	29217	50374022
Peri-implantitis	19.63	11.45	7	201878	33	50403206
Pain of skin	19.59	11.45	73	201812	7874	50395365
Blood pressure systolic increased	19.50	11.45	74	201811	35375	50367864
Lymphoedema	19.41	11.45	80	201805	9042	50394197
Adverse event	19.37	11.45	263	201622	43500	50359739
Hair disorder	19.36	11.45	21	201864	896	50402343
Pleural neoplasm	19.25	11.45	12	201873	229	50403010
Progressive multifocal leukoencephalopathy	19.04	11.45	11	201874	11446	50391793
Lung neoplasm malignant	18.88	11.45	116	201769	15368	50387871
Hallucination, visual	18.86	11.45	23	201862	16559	50386680
Panic attack	18.83	11.45	30	201855	19312	50383927
Muscle tightness	18.70	11.45	86	201799	10194	50393045
Vertebroplasty	18.67	11.45	13	201872	301	50402938
Triple negative breast cancer	18.63	11.45	9	201876	101	50403138
Mastectomy	18.60	11.45	26	201859	1443	50401796
Clavicle fracture	18.41	11.45	38	201847	2901	50400338
Ocular hyperaemia	18.35	11.45	33	201852	20259	50382980
Blood pressure diastolic decreased	18.33	11.45	24	201861	16757	50386482
Oral neoplasm benign	18.29	11.45	5	201880	7	50403232
Productive cough	18.24	11.45	129	201756	52565	50350674
Hepatic function abnormal	18.12	11.45	68	201817	32613	50370626
Lip and/or oral cavity cancer	18.09	11.45	13	201872	317	50402922
Hepatic cytolysis	18.00	11.45	5	201880	8098	50395141
Mental disorder	17.94	11.45	38	201847	21953	50381286
Proteinuria	17.86	11.45	24	201861	16573	50386666
Platelet count increased	17.80	11.45	19	201866	14521	50388718
Speech disorder	17.80	11.45	77	201808	35471	50367768
VIth nerve paresis	17.63	11.45	8	201877	77	50403162
Hypoaesthesia	17.62	11.45	647	201238	126610	50276629
Tricuspid valve incompetence	17.61	11.45	15	201870	12755	50390484
Gingival injury	17.61	11.45	6	201879	24	50403215
Aspergillus infection	17.60	11.45	3	201882	6818	50396421
Limb discomfort	17.48	11.45	161	201724	24196	50379043
Deformity	17.45	11.45	5	201880	7935	50395304
Blood urea increased	17.43	11.45	43	201842	23542	50379697
Wrong product administered	17.41	11.45	54	201831	5306	50397933
Pallor	17.37	11.45	42	201843	23157	50380082
CYP3A4 polymorphism	17.36	11.45	8	201877	80	50403159
Hypovolaemia	17.35	11.45	8	201877	9457	50393782
Anger	17.30	11.45	12	201873	11321	50391918
Ulna fracture	17.27	11.45	21	201864	1015	50402224
Pseudomonas infection	17.24	11.45	8	201877	9422	50393817
Metastases to bladder	17.11	11.45	10	201875	169	50403070
Heart rate irregular	17.04	11.45	32	201853	19328	50383911
Catheter site injury	17.01	11.45	9	201876	124	50403115
Epilepsy	16.99	11.45	38	201847	21529	50381710
Lip exfoliation	16.93	11.45	15	201870	498	50402741
Vertebral wedging	16.87	11.45	5	201880	11	50403228
Thrombotic microangiopathy	16.79	11.45	7	201878	8784	50394455
Ankylosing spondylitis	16.72	11.45	4	201881	7161	50396078
Malocclusion	16.70	11.45	8	201877	88	50403151
Metastases to adrenals	16.62	11.45	17	201868	677	50402562
Drug level decreased	16.58	11.45	3	201882	6530	50396709
Cerebral haemorrhage	16.54	11.45	54	201831	26998	50376241
Haemorrhage intracranial	16.50	11.45	15	201870	12359	50390880
Pre-existing condition improved	16.49	11.45	4	201881	7093	50396146
Upper gastrointestinal haemorrhage	16.45	11.45	24	201861	16011	50387228
Presyncope	16.44	11.45	46	201839	24152	50379087
Mood altered	16.43	11.45	16	201869	12757	50390482
Tenosynovitis	16.37	11.45	11	201874	10554	50392685
Osteochondrosis	16.36	11.45	21	201864	1073	50402166
Allergy to plants	16.30	11.45	16	201869	606	50402633
Eye irritation	16.29	11.45	27	201858	17113	50386126
Gingival discolouration	16.28	11.45	11	201874	242	50402997
Bladder cancer	16.27	11.45	39	201846	3293	50399946
Parathyroid tumour benign	16.26	11.45	16	201869	608	50402631
Stress	16.13	11.45	137	201748	53656	50349583
Activated partial thromboplastin time prolonged	16.12	11.45	3	201882	6399	50396840
Product administration error	16.11	11.45	34	201851	19665	50383574
Colitis	16.09	11.45	89	201796	38440	50364799
Bone marrow oedema	16.07	11.45	18	201867	796	50402443
Infusion site extravasation	16.07	11.45	4	201881	6972	50396267
Dental cyst	16.07	11.45	6	201879	33	50403206
Injection site warmth	16.02	11.45	19	201866	13847	50389392
Vertebral lesion	16.00	11.45	14	201871	457	50402782
Decreased immune responsiveness	15.99	11.45	43	201842	3898	50399341
Eastern Cooperative Oncology Group performance status worsened	15.96	11.45	16	201869	622	50402617
Drug eruption	15.95	11.45	45	201840	23561	50379678
Skin necrosis	15.94	11.45	12	201873	10855	50392384
Central nervous system lesion	15.93	11.45	9	201876	9480	50393759
Breast cancer recurrent	15.90	11.45	42	201843	3766	50399473
Dental paraesthesia	15.89	11.45	4	201881	3	50403236
Injected limb mobility decreased	15.89	11.45	4	201881	3	50403236
Panniculitis	15.88	11.45	7	201878	8496	50394743
Medial tibial stress syndrome	15.80	11.45	8	201877	100	50403139
Febrile bone marrow aplasia	15.80	11.45	3	201882	6308	50396931
Inflammation	15.73	11.45	148	201737	56764	50346475
Adnexa uteri mass	15.72	11.45	14	201871	468	50402771
Subarachnoid haemorrhage	15.68	11.45	12	201873	10764	50392475
Cancer pain	15.68	11.45	33	201852	2554	50400685
Spinal disorder	15.65	11.45	70	201815	8200	50395039
Facial pain	15.62	11.45	66	201819	7543	50395696
Thyroid operation	15.61	11.45	9	201876	148	50403091
Myocardial ischaemia	15.58	11.45	14	201871	11599	50391640
Pulmonary fibrosis	15.49	11.45	48	201837	24389	50378850
Chronic kidney disease	15.47	11.45	94	201791	39677	50363562
Electrolyte imbalance	15.45	11.45	28	201857	17141	50386098
Visual impairment	15.45	11.45	186	201699	68089	50335150
Haemodialysis	15.43	11.45	7	201878	8355	50394884
Psychomotor hyperactivity	15.36	11.45	9	201876	9292	50393947
Hypercalcaemic nephropathy	15.36	11.45	4	201881	4	50403235
Mitral valve incompetence	15.27	11.45	29	201856	17442	50385797
Cardiomegaly	15.27	11.45	25	201860	15920	50387319
Osteomalacia	15.26	11.45	16	201869	656	50402583
Intervertebral disc protrusion	15.24	11.45	136	201749	20257	50382982
Blood pressure abnormal	15.23	11.45	95	201790	12652	50390587
Cellulitis	15.21	11.45	380	201505	70418	50332821
Myelodysplastic syndrome	15.18	11.45	23	201862	15109	50388130
Bone deformity	15.16	11.45	14	201871	491	50402748
Myelosuppression	15.11	11.45	19	201866	13498	50389741
Oral pustule	15.11	11.45	6	201879	40	50403199
Rectal haemorrhage	15.06	11.45	91	201794	38467	50364772
Liver function test increased	15.05	11.45	52	201833	25554	50377685
Clostridium difficile colitis	15.03	11.45	30	201855	17712	50385527
Cholecystitis	14.99	11.45	20	201865	13851	50389388
Hypoaesthesia teeth	14.86	11.45	6	201879	42	50403197
Arthritis	14.83	11.45	452	201433	86269	50316970
Conjunctivitis	14.83	11.45	26	201859	16119	50387120
Demyelination	14.80	11.45	3	201882	6023	50397216
Brachiocephalic vein thrombosis	14.77	11.45	7	201878	75	50403164
Dyspnoea exertional	14.69	11.45	132	201753	51101	50352138
Subdural haematoma	14.68	11.45	18	201867	12929	50390310
Granuloma annulare	14.65	11.45	14	201871	513	50402726
Fracture pain	14.62	11.45	12	201873	358	50402881
Malabsorption	14.60	11.45	40	201845	3666	50399573
Hepatic lesion	14.55	11.45	42	201843	3966	50399273
Pulmonary congestion	14.51	11.45	24	201861	15223	50388016
Degenerative bone disease	14.51	11.45	6	201879	45	50403194
Crying	14.48	11.45	38	201847	20378	50382861
Rash erythematous	14.43	11.45	207	201678	34645	50368594
Giant cell arteritis	14.43	11.45	26	201859	1794	50401445
Cardiotoxicity	14.42	11.45	5	201880	7022	50396217
Inguinal hernia repair	14.40	11.45	6	201879	46	50403193
Pulmonary tumour thrombotic microangiopathy	14.29	11.45	6	201879	47	50403192
Muscle rigidity	14.23	11.45	11	201874	9818	50393421
Skin haemorrhage	14.20	11.45	60	201825	6858	50396381
Pleural disorder	14.18	11.45	14	201871	534	50402705
Diverticulitis	14.11	11.45	198	201687	32984	50370255
Transaminases increased	14.10	11.45	60	201825	27764	50375475
Gastroenteritis viral	14.08	11.45	34	201851	18752	50384487
Acetabulum fracture	14.05	11.45	10	201875	240	50402999
Bone sequestrum	14.01	11.45	22	201863	1356	50401883
Parkinsonism	14.00	11.45	9	201876	8838	50394401
Skin disorder	13.94	11.45	152	201733	23878	50379361
Encephalitis	13.90	11.45	6	201879	7374	50395865
Sternal fracture	13.88	11.45	27	201858	1975	50401264
Rash maculo-papular	13.78	11.45	57	201828	26584	50376655
General physical health deterioration	13.76	11.45	448	201437	141986	50261253
Small intestinal obstruction	13.76	11.45	27	201858	16041	50387198
Ventricular extrasystoles	13.72	11.45	13	201872	10503	50392736
Hepatic encephalopathy	13.68	11.45	11	201874	9625	50393614
Breath sounds abnormal	13.65	11.45	7	201878	7785	50395454
Platelet count decreased	13.61	11.45	302	201583	100424	50302815
Osteosarcoma recurrent	13.58	11.45	3	201882	0	50403239
Blood 1,25-dihydroxycholecalciferol increased	13.58	11.45	3	201882	0	50403239
Serum procollagen type I N-terminal propeptide decreased	13.58	11.45	3	201882	0	50403239
Bone giant cell tumour malignant	13.58	11.45	3	201882	0	50403239
Thyroid calcification	13.58	11.45	3	201882	0	50403239
C-telopeptide	13.58	11.45	3	201882	0	50403239
Masticatory pain	13.58	11.45	3	201882	0	50403239
Urine abnormality	13.58	11.45	4	201881	6234	50397005
Urinary retention	13.56	11.45	56	201829	26134	50377105
Tachyphylaxis	13.56	11.45	10	201875	254	50402985
Diffuse large B-cell lymphoma	13.53	11.45	3	201882	5659	50397580
Oligodipsia	13.47	11.45	5	201880	27	50403212
Urethritis noninfective	13.43	11.45	4	201881	9	50403230
Mucosal pain	13.43	11.45	4	201881	9	50403230
Chronic leukaemia	13.43	11.45	4	201881	9	50403230
Eye pain	13.42	11.45	63	201822	28386	50374853
Jaundice	13.38	11.45	57	201828	26372	50376867
Fibula fracture	13.38	11.45	34	201851	2978	50400261
Angina unstable	13.37	11.45	5	201880	6701	50396538
Haemophagocytic lymphohistiocytosis	13.36	11.45	9	201876	8624	50394615
Ovarian cyst	13.35	11.45	22	201863	13974	50389265
Tooth discolouration	13.34	11.45	17	201868	862	50402377
Hypotonia	13.25	11.45	8	201877	8126	50395113
Hypercalcaemia of malignancy	13.24	11.45	8	201877	144	50403095
Osteosclerosis	13.24	11.45	37	201848	3430	50399809
Carcinoid tumour pulmonary	13.23	11.45	12	201873	411	50402828
Periprosthetic fracture	13.20	11.45	12	201873	412	50402827
Hepatitis cholestatic	13.17	11.45	4	201881	6113	50397126
Dermatitis allergic	13.08	11.45	19	201866	12701	50390538
Onychalgia	13.07	11.45	16	201869	779	50402460
Colitis ulcerative	13.03	11.45	30	201855	16824	50386415
Toxic encephalopathy	13.03	11.45	3	201882	5512	50397727
Acute generalised exanthematous pustulosis	12.95	11.45	10	201875	8928	50394311
Apathy	12.90	11.45	7	201878	7541	50395698
Bone scan abnormal	12.89	11.45	11	201874	347	50402892
Fear	12.85	11.45	24	201861	14525	50388714
Injection site urticaria	12.81	11.45	18	201867	12199	50391040
Gallbladder disorder	12.78	11.45	30	201855	16712	50386527
Enteritis	12.69	11.45	6	201879	6989	50396250
Blood cholesterol abnormal	12.68	11.45	28	201857	2240	50400999
Pulmonary haemorrhage	12.68	11.45	5	201880	6487	50396752
Injection site induration	12.67	11.45	9	201876	8388	50394851
Mood swings	12.66	11.45	28	201857	15926	50387313
Eosinophil count increased	12.64	11.45	10	201875	8820	50394419
Aspiration	12.63	11.45	11	201874	9253	50393986
Carbohydrate antigen 19-9 increased	12.55	11.45	8	201877	159	50403080
Bone fistula	12.52	11.45	6	201879	66	50403173
Quality of life decreased	12.51	11.45	54	201831	6229	50397010
Sinus congestion	12.38	11.45	23	201862	13948	50389291
Varicophlebitis	12.38	11.45	4	201881	13	50403226
Infusion site erythema	12.34	11.45	10	201875	8717	50394522
Urine output decreased	12.34	11.45	14	201871	10407	50392832
Hypercalciuria	12.33	11.45	9	201876	225	50403014
Hot flush	12.30	11.45	246	201639	43923	50359316
Thinking abnormal	12.28	11.45	12	201873	9555	50393684
Cardiac murmur	12.22	11.45	15	201870	10769	50392470
Metastases to neck	12.21	11.45	6	201879	70	50403169
Pneumonia viral	12.18	11.45	6	201879	6828	50396411
Face oedema	12.06	11.45	34	201851	17805	50385434
Device difficult to use	12.01	11.45	13	201872	9873	50393366
Fibromyalgia	11.99	11.45	118	201767	44860	50358379
Skin sensitisation	11.97	11.45	15	201870	748	50402491
Bipolar disorder	11.94	11.45	6	201879	6751	50396488
Blood pressure systolic decreased	11.92	11.45	4	201881	5735	50397504
Nail growth abnormal	11.92	11.45	12	201873	469	50402770
Jaw cyst	11.89	11.45	7	201878	120	50403119
Rhinorrhoea	11.87	11.45	140	201745	51443	50351796
Troponin increased	11.86	11.45	9	201876	8109	50395130
Lipase increased	11.82	11.45	10	201875	8531	50394708
Ear disorder	11.79	11.45	34	201851	3209	50400030
Multiple sclerosis	11.79	11.45	42	201843	20451	50382788
Abnormal dreams	11.77	11.45	12	201873	9365	50393874
Pathogen resistance	11.75	11.45	4	201881	5685	50397554
Callus formation delayed	11.74	11.45	4	201881	16	50403223
Transfusion	11.65	11.45	21	201864	12884	50390355
Vascular fragility	11.64	11.45	7	201878	125	50403114
Papule	11.63	11.45	41	201844	4304	50398935
Motor dysfunction	11.61	11.45	9	201876	8022	50395217
Nephropathy toxic	11.61	11.45	9	201876	8020	50395219
Hepatic cancer	11.58	11.45	34	201851	3241	50399998
Blood potassium decreased	11.57	11.45	93	201792	36852	50366387
Metastases to vagina	11.55	11.45	4	201881	17	50403222
Extradural neoplasm	11.52	11.45	3	201882	3	50403236
Parathyroid hormone-related protein increased	11.52	11.45	3	201882	3	50403236
Tartrate-resistant acid phosphatase increased	11.52	11.45	3	201882	3	50403236
Bone erosion	11.50	11.45	18	201867	11669	50391570
Tuberculosis	11.45	11.45	14	201871	10069	50393170

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Osteonecrosis of jaw	7496.78	13.80	2083	36879	14427	29521138
Off label use	4104.42	13.80	3255	35707	297545	29238020
Death	1849.69	13.80	2243	36719	339841	29195724
Hypocalcaemia	1770.94	13.80	750	38212	19915	29515650
Terminal state	585.97	13.80	207	38755	3287	29532278
Prostatic specific antigen increased	350.78	13.80	214	38748	12350	29523215
Tooth disorder	309.58	13.80	179	38783	9350	29526215
Metastases to bone	308.52	13.80	181	38781	9717	29525848
Tooth extraction	294.61	13.80	132	38830	3997	29531568
Investigation	248.71	13.80	77	38885	787	29534778
Pain in jaw	226.12	13.80	158	38804	11483	29524082
Hospitalisation	225.35	13.80	290	38672	45698	29489867
Bone pain	223.28	13.80	189	38773	18263	29517302
Malignant neoplasm progression	215.78	13.80	365	38597	73494	29462071
Atypical femur fracture	203.74	13.80	52	38910	239	29535326
Prostate cancer metastatic	179.34	13.80	100	38862	4866	29530699
Exposed bone in jaw	175.26	13.80	68	38894	1418	29534147
Blood calcium decreased	172.21	13.80	122	38840	9060	29526505
Hypophosphataemia	166.72	13.80	113	38849	7811	29527754
Blood parathyroid hormone increased	156.25	13.80	61	38901	1294	29534271
Toxicity to various agents	142.49	13.80	28	38934	173633	29361932
Jaw disorder	139.36	13.80	63	38899	1947	29533618
Osteomyelitis	129.26	13.80	122	38840	13587	29521978
Prostate cancer	117.20	13.80	156	38806	25371	29510194
Osteitis	114.55	13.80	50	38912	1419	29534146
Drug ineffective	114.06	13.80	190	38772	362980	29172585
Hypercalcaemia	107.96	13.80	107	38855	12652	29522913
Completed suicide	101.49	13.80	4	38958	90242	29445323
Toothache	101.38	13.80	73	38889	5559	29530006
Drug interaction	93.48	13.80	74	38888	197311	29338254
Bone density abnormal	84.63	13.80	19	38943	43	29535522
Occupational exposure to product	82.33	13.80	26	38936	285	29535280
Hot flush	79.44	13.80	98	38864	14772	29520793
Back pain	76.83	13.80	302	38660	101982	29433583
Dental care	74.66	13.80	22	38940	187	29535378
Condition aggravated	71.56	13.80	53	38909	146242	29389323
Hypotension	71.26	13.80	91	38871	194263	29341302
Abscess jaw	69.21	13.80	28	38934	654	29534911
Hormone-refractory prostate cancer	67.90	13.80	27	38935	602	29534963
Spinal fracture	67.48	13.80	61	38901	6425	29529140
Acute kidney injury	62.60	13.80	163	38799	265104	29270461
Tooth fracture	61.64	13.80	43	38919	3113	29532452
Metastases to lung	61.18	13.80	63	38899	7792	29527773
Incorrect route of product administration	60.64	13.80	73	38889	10728	29524837
Cardiac arrest	58.28	13.80	20	38942	85571	29449994
Osteonecrosis	58.04	13.80	80	38882	13439	29522126
Dental implantation	57.23	13.80	14	38948	52	29535513
Femur fracture	56.14	13.80	57	38905	6934	29528631
Pathological fracture	53.95	13.80	43	38919	3812	29531753
Blood calcium abnormal	53.89	13.80	21	38941	443	29535122
Overdose	53.74	13.80	19	38943	79800	29455765
Jaw operation	53.69	13.80	17	38945	188	29535377
Accidental exposure to product	52.87	13.80	68	38894	10685	29524880
Tetany	49.89	13.80	22	38940	640	29534925
Metastasis	49.60	13.80	39	38923	3390	29532175
Dental caries	46.83	13.80	41	38921	4139	29531426
Metastases to lymph nodes	46.21	13.80	40	38922	3977	29531588
Tooth loss	45.16	13.80	38	38924	3636	29531929
Bone fissure	45.05	13.80	10	38952	21	29535544
Fracture	44.37	13.80	47	38915	6006	29529559
Tooth abscess	44.17	13.80	43	38919	4971	29530594
Impaired healing	43.51	13.80	70	38892	13488	29522077
Thoracic vertebral fracture	42.05	13.80	25	38937	1373	29534192
Fatigue	41.67	13.80	616	38346	316205	29219360
Endodontic procedure	40.82	13.80	16	38946	343	29535222
Agitation	40.49	13.80	9	38953	51295	29484270
Bradycardia	40.27	13.80	18	38944	65611	29469954
Gastrointestinal haemorrhage	39.90	13.80	28	38934	79505	29456060
Blood phosphorus decreased	38.84	13.80	31	38931	2754	29532811
Exostosis of jaw	38.25	13.80	11	38951	85	29535480
Bone density decreased	37.83	13.80	25	38937	1655	29533910
Loose tooth	36.80	13.80	21	38941	1068	29534497
Cardio-respiratory arrest	35.88	13.80	11	38951	50590	29484975
Artificial crown procedure	35.66	13.80	8	38954	18	29535547
Decreased appetite	35.51	13.80	319	38643	145023	29390542
Jaw fistula	35.50	13.80	9	38953	40	29535525
Metastases to central nervous system	34.91	13.80	45	38917	7086	29528479
Hip fracture	34.80	13.80	55	38907	10437	29525128
Cancer pain	34.61	13.80	27	38935	2320	29533245
Tachycardia	34.38	13.80	27	38935	72383	29463182
Drug hypersensitivity	33.12	13.80	25	38937	68381	29467184
Respiratory failure	32.98	13.80	48	38914	97083	29438482
Prostate cancer recurrent	31.87	13.80	18	38944	897	29534668
Chest pain	31.87	13.80	62	38900	111911	29423654
Stress fracture	31.57	13.80	17	38945	771	29534794
Hospice care	31.34	13.80	36	38926	5032	29530533
Coma	30.97	13.80	7	38955	39443	29496122
Spinal pain	30.84	13.80	35	38927	4829	29530736
International normalised ratio increased	30.83	13.80	10	38952	44362	29491203
Gingival disorder	30.79	13.80	20	38942	1286	29534279
Seizure	30.66	13.80	47	38915	93076	29442489
Palliative care	30.51	13.80	14	38948	448	29535117
Failure to anastomose	29.54	13.80	11	38951	204	29535361
Blood calcium increased	29.10	13.80	28	38934	3191	29532374
Sequestrectomy	28.82	13.80	11	38951	219	29535346
Dental fistula	28.39	13.80	9	38953	100	29535465
Metastases to soft tissue	28.36	13.80	11	38951	229	29535336
Metastases to spine	27.77	13.80	23	38939	2153	29533412
Suicidal ideation	27.57	13.80	6	38956	34710	29500855
Atypical fracture	27.03	13.80	9	38953	118	29535447
Periodontitis	27.00	13.80	21	38941	1796	29533769
Carbohydrate antigen 15-3 increased	26.94	13.80	8	38954	70	29535495
Hyperparathyroidism	25.80	13.80	17	38945	1120	29534445
Febrile neutropenia	25.60	13.80	70	38892	112170	29423395
Gingivitis	25.48	13.80	25	38937	2917	29532648
Lumbar vertebral fracture	25.14	13.80	20	38942	1768	29533797
Metastases to liver	24.99	13.80	51	38911	11805	29523760
Neoplasm progression	24.89	13.80	67	38895	18545	29517020
Arthralgia	24.76	13.80	287	38675	139330	29396235
Aggression	24.71	13.80	8	38954	35533	29500032
Bone disorder	24.48	13.80	34	38928	5749	29529816
Blood glucose increased	24.39	13.80	25	38937	58959	29476606
Disease progression	24.35	13.80	188	38774	81728	29453837
Hypoglycaemia	24.27	13.80	17	38945	48329	29487236
Myocardial infarction	24.26	13.80	70	38892	110226	29425339
Septic shock	24.23	13.80	28	38934	62532	29473033
Tooth infection	24.10	13.80	33	38929	5506	29530059
Gingival swelling	23.40	13.80	16	38946	1121	29534444
Inappropriate schedule of product administration	23.25	13.80	118	38844	44354	29491211
Mastication disorder	23.11	13.80	16	38946	1144	29534421
Bone loss	22.77	13.80	12	38950	521	29535044
Confusional state	22.76	13.80	89	38873	127788	29407777
Multiple organ dysfunction syndrome	22.60	13.80	30	38932	63086	29472479
Bone giant cell tumour malignant	22.53	13.80	4	38958	0	29535565
Osteonecrosis of external auditory canal	22.53	13.80	4	38958	0	29535565
Peri-implantitis	22.53	13.80	4	38958	0	29535565
Lactic acidosis	22.50	13.80	6	38956	30241	29505324
Pseudarthrosis	22.48	13.80	7	38955	73	29535492
Nephrocalcinosis	22.39	13.80	12	38950	539	29535026
Abdominal pain	21.74	13.80	98	38864	135259	29400306
Alanine aminotransferase increased	21.30	13.80	38	38924	70906	29464659
Parathyroid tumour malignant	21.26	13.80	5	38957	15	29535550
Suture rupture	21.20	13.80	10	38952	341	29535224
Respiratory distress	20.99	13.80	8	38954	32098	29503467
Macroenzyme creatine kinase	20.78	13.80	5	38957	17	29535548
Prostatic specific antigen decreased	20.67	13.80	7	38955	97	29535468
Limbic encephalitis	20.65	13.80	10	38952	362	29535203
Gingival abscess	20.61	13.80	8	38954	167	29535398
Coronary artery disease	20.31	13.80	17	38945	44173	29491392
Bone formation increased	20.30	13.80	4	38958	3	29535562
Spinal compression fracture	20.28	13.80	32	38930	6062	29529503
Bone lesion	19.82	13.80	21	38941	2683	29532882
Blood bilirubin increased	19.70	13.80	10	38952	33883	29501682
Weight increased	19.66	13.80	45	38917	76622	29458943
Dental restoration failure	19.58	13.80	5	38957	23	29535542
Psoriasis	19.51	13.80	9	38953	32218	29503347
Depression	19.48	13.80	53	38909	85094	29450471
Respiratory arrest	19.45	13.80	5	38957	25828	29509737
Metabolic acidosis	19.22	13.80	13	38949	37649	29497916
Product use in unapproved indication	19.19	13.80	55	38907	86820	29448745
Abscess oral	19.19	13.80	9	38953	303	29535262
Cough	19.03	13.80	94	38868	126633	29408932
Tremor	18.99	13.80	43	38919	73495	29462070
Extraskeletal ossification	18.77	13.80	5	38957	28	29535537
Hungry bone syndrome	18.66	13.80	6	38956	70	29535495
Shock	18.48	13.80	3	38959	21401	29514164
Blood urea increased	18.39	13.80	7	38955	28105	29507460
Abnormal behaviour	18.36	13.80	4	38958	23123	29512442
Dysgeusia	17.83	13.80	68	38894	22606	29512959
Pain	17.47	13.80	320	38642	171112	29364453
Eosinophilia	17.25	13.80	4	38958	22157	29513408
Calcium ionised abnormal	16.90	13.80	3	38959	0	29535565
Product use issue	16.89	13.80	26	38936	51418	29484147
Gingival pain	16.81	13.80	17	38945	2057	29533508
Vipoma	16.76	13.80	4	38958	13	29535552
Postrenal failure	16.56	13.80	9	38953	416	29535149
Jaw fracture	16.53	13.80	12	38950	925	29534640
Living in residential institution	16.51	13.80	8	38954	290	29535275
Oxygen saturation decreased	16.46	13.80	21	38941	44916	29490649
Bedridden	16.33	13.80	21	38941	3297	29532268
Haematemesis	16.33	13.80	6	38956	24620	29510945
Angioedema	16.31	13.80	11	38951	31904	29503661
Wheezing	16.27	13.80	12	38950	33228	29502337
Pyrexia	16.23	13.80	274	38688	287348	29248217
Acute respiratory distress syndrome	16.23	13.80	5	38957	22930	29512635
Headache	16.13	13.80	149	38813	173858	29361707
Blood creatine phosphokinase increased	15.94	13.80	18	38944	40626	29494939
Blood pressure decreased	15.89	13.80	22	38940	45455	29490110
Hyperaesthesia	15.60	13.80	21	38941	3448	29532117
Asthma	15.58	13.80	13	38949	33836	29501729
Cystitis	15.53	13.80	34	38928	8258	29527307
Anxiety	15.44	13.80	59	38903	85306	29450259
Vitamin D increased	15.35	13.80	5	38957	61	29535504
Hallucination	15.26	13.80	22	38940	44690	29490875
Neoplasm malignant	15.20	13.80	53	38909	16872	29518693
Paraesthesia	15.12	13.80	122	38840	53723	29481842
Dental operation	14.87	13.80	8	38954	362	29535203
Cytomegalovirus infection	14.82	13.80	6	38956	23209	29512356
Bone fistula	14.64	13.80	4	38958	25	29535540
Lung cyst	14.64	13.80	4	38958	25	29535540
Tibia fracture	14.64	13.80	13	38949	1337	29534228
Pulpitis dental	14.57	13.80	8	38954	377	29535188
Oral cavity fistula	14.56	13.80	6	38956	147	29535418
Noninfective gingivitis	14.46	13.80	7	38955	253	29535312
Hypersensitivity	14.43	13.80	30	38932	52873	29482692
Chest discomfort	14.38	13.80	24	38938	45959	29489606
Traumatic fracture	14.36	13.80	7	38955	257	29535308
Poor peripheral circulation	14.28	13.80	13	38949	1381	29534184
Bone giant cell tumour	14.25	13.80	4	38958	28	29535537
Sepsis	14.18	13.80	120	38842	142562	29393003
Acetabulum fracture	14.12	13.80	7	38955	267	29535298
Cardiogenic shock	13.91	13.80	4	38958	19186	29516379
Sedation	13.83	13.80	3	38959	17402	29518163

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	29352.89	11.44	19852	175284	612954	63690642
Osteonecrosis of jaw	13019.75	11.44	4788	190348	35037	64268559
Death	5981.53	11.44	7291	187845	475414	63828182
Hypocalcaemia	2248.96	11.44	1462	193674	40291	64263305
Bone pain	1726.11	11.44	1308	193828	46264	64257332
Tooth disorder	1689.13	11.44	973	194163	21429	64282167
Spinal fracture	1392.26	11.44	750	194386	14424	64289172
Pain in jaw	1318.08	11.44	1047	194089	39708	64263888
Tooth extraction	1267.95	11.44	607	194529	8994	64294602
Atypical femur fracture	1241.81	11.44	485	194651	4213	64299383
Back pain	1226.65	11.44	2479	192657	247692	64055904
Pain in extremity	1064.64	11.44	2629	192507	300456	64003140
Drug ineffective	872.68	11.44	760	194376	839487	63464109
Arthralgia	858.36	11.44	3109	192027	439151	63864445
Bone density abnormal	820.66	11.44	310	194826	2435	64301161
Toxicity to various agents	787.13	11.44	90	195046	363423	63940173
Tooth fracture	705.19	11.44	415	194721	9512	64294084
Thoracic vertebral fracture	684.87	11.44	315	194821	4238	64299358
Myalgia	684.08	11.44	1493	193643	157124	64146472
Completed suicide	645.74	11.44	6	195130	224408	64079188
Metastases to bone	645.46	11.44	518	194618	19917	64283679
Toothache	637.01	11.44	482	194654	16977	64286619
Terminal state	632.81	11.44	296	194840	4148	64299448
Exposed bone in jaw	603.21	11.44	266	194870	3221	64300375
Lumbar vertebral fracture	601.76	11.44	306	194830	5196	64298400
Rebound effect	586.41	11.44	290	194846	4627	64298969
Drug interaction	580.00	11.44	187	194949	361896	63941700
Bone density decreased	578.60	11.44	366	194770	9586	64294010
Jaw disorder	499.76	11.44	255	194881	4362	64299234
Hospitalisation	481.70	11.44	837	194299	74370	64229226
Acute kidney injury	462.51	11.44	408	194728	448832	63854764
Femur fracture	447.12	11.44	534	194602	33601	64269995
Spinal compression fracture	423.48	11.44	354	194782	14421	64289175
Investigation	419.50	11.44	181	194955	2071	64301525
Blood parathyroid hormone increased	419.37	11.44	200	194936	2934	64300662
Dental implantation	406.77	11.44	116	195020	312	64303284
Groin pain	399.01	11.44	307	194829	11086	64292510
Tooth loss	396.63	11.44	243	194893	6004	64297592
Drug abuse	383.21	11.44	3	195133	132371	64171225
Osteomyelitis	376.90	11.44	441	194695	27146	64276450
Pathological fracture	376.67	11.44	270	194866	8735	64294861
Hypotension	368.34	11.44	366	194770	380608	63922988
Loose tooth	355.69	11.44	175	194961	2759	64300837
Musculoskeletal pain	350.86	11.44	766	194370	80528	64223068
Hip fracture	335.43	11.44	412	194724	26687	64276909
Condition aggravated	334.06	11.44	381	194755	372045	63931551
Bone loss	305.15	11.44	143	194993	2012	64301584
Breast cancer metastatic	295.38	11.44	213	194923	6956	64296640
Overdose	293.96	11.44	62	195074	159504	64144092
Blood calcium decreased	288.39	11.44	371	194765	25183	64278413
Dental care	285.86	11.44	101	195035	640	64302956
Dental caries	281.38	11.44	245	194891	10555	64293041
Fracture	259.82	11.44	302	194834	18453	64285143
Bone disorder	256.17	11.44	284	194852	16475	64287121
Intentional overdose	255.78	11.44	3	195133	89941	64213655
Neoplasm progression	254.48	11.44	450	194686	40514	64263082
Infusion related reaction	252.41	11.44	91	195045	164376	64139220
Mobility decreased	243.44	11.44	689	194447	85151	64218445
Cardiac arrest	238.54	11.44	84	195052	153980	64149616
Jaw operation	235.17	11.44	88	195048	671	64302925
Incorrect route of product administration	230.25	11.44	317	194819	22981	64280615
Product use in unapproved indication	226.73	11.44	126	195010	176492	64127104
Drug intolerance	226.04	11.44	145	194991	187847	64115749
Accidental exposure to product	224.25	11.44	334	194802	26030	64277566
Foot fracture	222.99	11.44	275	194861	17882	64285714
Muscle spasms	221.19	11.44	929	194207	140094	64163502
Blood calcium increased	218.96	11.44	192	194944	8350	64295246
Metastases to liver	217.67	11.44	313	194823	23628	64279968
Endodontic procedure	216.29	11.44	116	195020	2207	64301389
Exposure during pregnancy	214.84	11.44	4	195132	77671	64225925
Exostosis of jaw	212.72	11.44	93	195043	1101	64302495
Maternal exposure during pregnancy	211.53	11.44	22	195114	95862	64207734
Synovitis	207.99	11.44	27	195109	99063	64204533
Treatment failure	207.84	11.44	49	195087	116767	64186829
Drug hypersensitivity	203.68	11.44	252	194884	237563	64066033
Contraindicated product administered	200.40	11.44	41	195095	107788	64195808
Confusional state	200.19	11.44	300	194836	260844	64042752
Bradycardia	199.92	11.44	55	195081	118164	64185432
Tooth abscess	190.45	11.44	222	194914	13604	64289992
Product use issue	187.92	11.44	113	195023	151602	64151994
Prostatic specific antigen increased	183.77	11.44	176	194960	8584	64295012
Gingival pain	183.36	11.44	153	194983	6214	64297382
Somnolence	178.36	11.44	212	194924	203433	64100163
Osteitis	178.20	11.44	120	195016	3502	64300094
Cardio-respiratory arrest	175.57	11.44	41	195095	98352	64205244
Suicide attempt	171.24	11.44	11	195125	70996	64232600
Gingival disorder	169.83	11.44	113	195023	3231	64300365
Spinal pain	167.78	11.44	199	194937	12422	64291174
Tachycardia	164.43	11.44	127	195009	149452	64154144
Temporomandibular joint syndrome	163.71	11.44	111	195025	3277	64300319
Seizure	163.66	11.44	158	194978	166734	64136862
Gastrointestinal haemorrhage	163.22	11.44	99	195037	132213	64171383
Dyspnoea	163.10	11.44	1392	193744	717282	63586314
Tetany	162.69	11.44	94	195042	2078	64301518
Abscess jaw	161.85	11.44	85	195051	1547	64302049
Gingivitis	160.90	11.44	154	194982	7505	64296091
Cystitis	159.48	11.44	380	194756	42295	64261301
Coma	159.35	11.44	35	195101	87580	64216016
Febrile neutropenia	157.34	11.44	202	194934	187455	64116141
Malignant neoplasm progression	155.96	11.44	716	194420	112155	64191441
Vomiting	155.73	11.44	1003	194133	550114	63753482
Hepatic enzyme increased	155.09	11.44	101	195035	129842	64173754
Pemphigus	153.86	11.44	7	195129	60694	64242902
Compression fracture	152.90	11.44	132	195004	5620	64297976
Product storage error	152.84	11.44	195	194941	13123	64290473
Hypoglycaemia	151.64	11.44	42	195094	89850	64213746
Stress fracture	151.40	11.44	130	195006	5494	64298102
Therapeutic product effect decreased	149.86	11.44	81	195055	115270	64188326
Lactic acidosis	149.63	11.44	9	195127	61401	64242195
Respiratory failure	147.40	11.44	162	194974	161021	64142575
Pyrexia	145.24	11.44	1042	194094	557602	63745994
Wrist fracture	145.18	11.44	165	194971	9836	64293760
Osteonecrosis	145.17	11.44	286	194850	27943	64275653
Eczema	144.33	11.44	294	194842	29426	64274170
Blood calcium abnormal	143.72	11.44	72	195064	1182	64302414
International normalised ratio increased	143.21	11.44	32	195104	79135	64224461
Sequestrectomy	141.16	11.44	63	195073	786	64302810
Agitation	140.52	11.44	46	195090	88321	64215275
Tooth infection	140.27	11.44	196	194940	14405	64289191
Hypercalcaemia	137.68	11.44	298	194838	31118	64272478
Hyperaesthesia teeth	137.30	11.44	75	195061	1482	64302114
Multiple organ dysfunction syndrome	136.51	11.44	68	195068	101345	64202251
Lower limb fracture	136.39	11.44	186	194950	13359	64290237
Artificial crown procedure	135.38	11.44	44	195092	207	64303389
Breast cancer	134.10	11.44	282	194854	28866	64274730
Hypophosphataemia	133.15	11.44	192	194944	14528	64289068
Dental restoration failure	131.82	11.44	54	195082	537	64303059
Gingival recession	131.35	11.44	65	195071	1038	64302558
Periodontitis	130.38	11.44	105	195031	4054	64299542
Multiple fractures	127.93	11.44	122	195014	5918	64297678
Pelvic fracture	126.51	11.44	158	194978	10405	64293191
Metastases to lung	126.40	11.44	191	194945	15073	64288523
Atypical fracture	126.38	11.44	54	195082	602	64302994
Pneumonia	124.86	11.44	1088	194048	558488	63745108
Depressed level of consciousness	121.61	11.44	47	195089	81389	64222207
Gingival swelling	120.84	11.44	98	195038	3822	64299774
Metabolic acidosis	119.97	11.44	33	195103	70925	64232671
Oxygen saturation decreased	119.04	11.44	90	195046	107086	64196510
Suicidal ideation	118.16	11.44	28	195108	66514	64237082
Alanine aminotransferase increased	117.19	11.44	149	194987	138882	64164714
Pain	116.63	11.44	2334	192802	551177	63752419
Musculoskeletal discomfort	115.84	11.44	190	194946	16087	64287509
Systemic lupus erythematosus	115.56	11.44	45	195091	77567	64226029
Impaired healing	115.47	11.44	424	194712	60049	64243547
Unresponsive to stimuli	115.27	11.44	10	195126	50383	64253213
Intentional product use issue	113.94	11.44	74	195062	95290	64208306
Carbohydrate antigen 15-3 increased	111.15	11.44	56	195080	931	64302665
Hyponatraemia	110.12	11.44	174	194962	148165	64155431
Respiratory arrest	109.82	11.44	15	195121	52970	64250626
Joint swelling	109.41	11.44	313	194823	215069	64088527
Abdominal pain	107.81	11.44	532	194604	311843	63991753
Paraesthesia	107.31	11.44	736	194400	133786	64169810
Vitamin D decreased	106.82	11.44	124	195012	7563	64296033
Metastases to lymph nodes	105.38	11.44	131	195005	8586	64295010
Inappropriate schedule of product administration	105.01	11.44	554	194582	91732	64211864
Rib fracture	104.17	11.44	227	194909	23811	64279785
Rash pruritic	102.56	11.44	394	194742	57010	64246586
Serotonin syndrome	101.31	11.44	4	195132	39278	64264318
Hypoxia	100.51	11.44	72	195064	88077	64215519
Occupational exposure to product	100.01	11.44	45	195091	573	64303023
Renal failure	99.05	11.44	255	194881	181433	64122163
Osteonecrosis of external auditory canal	98.88	11.44	29	195107	89	64303507
Mastication disorder	98.72	11.44	71	195065	2308	64301288
Pericarditis	98.58	11.44	33	195103	62483	64241113
Syncope	96.50	11.44	208	194928	157427	64146169
Rhabdomyolysis	95.64	11.44	82	195054	91644	64211952
Sleep disorder due to a general medical condition	95.17	11.44	121	195015	8113	64295483
Encephalopathy	94.60	11.44	30	195106	58789	64244807
Upper limb fracture	94.48	11.44	165	194971	14701	64288895
Hyperkalaemia	94.24	11.44	100	195036	101029	64202567
Product dose omission issue	93.35	11.44	950	194186	193797	64109799
Blood pressure decreased	92.41	11.44	75	195061	86124	64217472
Septic shock	91.99	11.44	110	195026	105327	64198269
Bedridden	91.64	11.44	132	195004	9977	64293619
Tumour marker increased	91.35	11.44	79	195057	3371	64300225
Sepsis	91.01	11.44	373	194763	229968	64073628
Weight increased	90.35	11.44	336	194800	213012	64090584
Pancytopenia	89.47	11.44	187	194949	143122	64160474
Fall	89.42	11.44	1763	193373	415063	63888533
Neoplasm malignant	88.12	11.44	216	194920	24472	64279124
Aspartate aminotransferase increased	87.49	11.44	142	194994	119646	64183950
Drug reaction with eosinophilia and systemic symptoms	86.58	11.44	28	195108	54189	64249407
Hospice care	86.48	11.44	111	195025	7514	64296082
Helicobacter infection	84.08	11.44	9	195127	38353	64265243
Anaphylactic reaction	83.78	11.44	52	195084	68612	64234984
Toxic epidermal necrolysis	83.33	11.44	8	195128	37158	64266438
Aggression	82.98	11.44	19	195117	46213	64257383
Metastases to central nervous system	82.74	11.44	150	194986	13762	64289834
Prostate cancer metastatic	82.15	11.44	73	195063	3231	64300365
Dental operation	81.58	11.44	45	195091	907	64302689
Gait disturbance	80.68	11.44	836	194300	171319	64132277
Drug level increased	80.40	11.44	6	195130	34190	64269406
Multiple sclerosis relapse	79.89	11.44	14	195122	41121	64262475
Duodenal ulcer perforation	78.84	11.44	7	195129	34618	64268978
Blood creatine phosphokinase increased	77.68	11.44	40	195096	58518	64245078
Dry skin	76.22	11.44	332	194804	50829	64252767
Psychotic disorder	76.07	11.44	8	195128	34570	64269026
Dental fistula	76.07	11.44	35	195101	471	64303125
Hand deformity	75.94	11.44	48	195088	62723	64240873
Gingival abscess	75.39	11.44	39	195097	687	64302909
Femoral neck fracture	74.85	11.44	111	195025	8613	64294983
Intentional self-injury	74.76	11.44	3	195133	29041	64274555
Jaw fistula	74.35	11.44	23	195113	89	64303507
Loss of consciousness	74.28	11.44	217	194919	148148	64155448
Coronary artery disease	73.41	11.44	46	195090	60387	64243209
Wound	73.08	11.44	74	195062	76403	64227193
Hyperparathyroidism	72.88	11.44	64	195072	2788	64300808
Fractured sacrum	72.88	11.44	49	195087	1426	64302170
Myocardial infarction	71.60	11.44	259	194877	165562	64138034
Tooth erosion	71.13	11.44	31	195105	364	64303232
Chest pain	70.80	11.44	421	194715	235559	64068037
Body height decreased	70.47	11.44	100	195036	7454	64296142
Metastases to spine	70.44	11.44	70	195066	3573	64300023
Wheezing	70.35	11.44	84	195052	80495	64223101
Joint noise	70.18	11.44	66	195070	3145	64300451
Hallucination	70.05	11.44	70	195066	72718	64230878
Sciatica	69.90	11.44	175	194961	20089	64283507
Orthostatic hypotension	69.73	11.44	27	195109	46711	64256885
Neck pain	69.71	11.44	369	194767	61164	64242432
Eosinophilia	69.64	11.44	15	195121	38061	64265535
Rheumatoid arthritis	68.72	11.44	260	194876	164034	64139562
Mental status changes	68.36	11.44	51	195085	61111	64242485
Pulpitis dental	68.18	11.44	41	195095	978	64302618
Hot flush	67.32	11.44	298	194838	45937	64257659
Influenza like illness	67.17	11.44	366	194770	61336	64242260
Chest discomfort	65.54	11.44	160	194976	115946	64187650
Cytomegalovirus infection	65.36	11.44	16	195120	37183	64266413
Sedation	65.17	11.44	22	195114	41440	64262156
Tibia fracture	65.03	11.44	76	195060	4669	64298927
Oral pain	64.04	11.44	206	194930	27287	64276309
Folliculitis	63.56	11.44	8	195128	30069	64273527
Dysarthria	63.28	11.44	52	195084	59354	64244242
Psoriatic arthropathy	62.94	11.44	26	195110	43255	64260341
Delirium	62.71	11.44	70	195066	69124	64234472
Incorrect dose administered	62.51	11.44	55	195081	60710	64242886
Glossodynia	62.50	11.44	62	195074	64634	64238962
Haematemesis	62.50	11.44	32	195104	46967	64256629
Drug withdrawal syndrome	62.21	11.44	10	195126	31281	64272315
C-telopeptide increased	61.60	11.44	14	195122	7	64303589
Dermatitis	61.45	11.44	155	194981	17874	64285722
Generalised tonic-clonic seizure	61.18	11.44	22	195114	39835	64263761
Abortion spontaneous	60.30	11.44	4	195132	25139	64278457
Heart rate decreased	60.16	11.44	47	195089	55020	64248576
Scoliosis	58.95	11.44	82	195054	6000	64297596
Acute respiratory distress syndrome	58.91	11.44	22	195114	38913	64264683
Humerus fracture	58.77	11.44	94	195042	7791	64295805
Metastasis	58.54	11.44	79	195057	5616	64297980
Muscle injury	58.46	11.44	6	195130	26431	64277165
Dental necrosis	58.40	11.44	21	195115	141	64303455
Walking aid user	58.38	11.44	83	195053	6198	64297398
Dental cleaning	58.10	11.44	14	195122	13	64303583
Respiratory distress	58.02	11.44	44	195092	52287	64251309
Ear pain	57.33	11.44	187	194949	24949	64278647
Dehydration	57.23	11.44	402	194734	216361	64087235
Bone lesion	57.03	11.44	74	195062	5063	64298533
Emotional distress	56.85	11.44	19	195117	36019	64267577
Thrombocytopenia	56.21	11.44	421	194715	223380	64080216
Adverse drug reaction	55.92	11.44	279	194857	45185	64258411
Cardiac failure congestive	55.67	11.44	205	194931	130375	64173221
Headache	55.09	11.44	1202	193934	528265	63775331
Labelled drug-drug interaction medication error	54.45	11.44	3	195133	22059	64281537
Tremor	54.25	11.44	247	194889	147983	64155613
C-reactive protein abnormal	54.04	11.44	11	195125	29036	64274560
Oedema	54.03	11.44	124	195012	91811	64211785
Blood glucose increased	53.91	11.44	137	194999	97936	64205660
Ventricular fibrillation	53.85	11.44	5	195131	23855	64279741
Atrial fibrillation	53.56	11.44	301	194835	170788	64132808
Blood bilirubin increased	53.51	11.44	57	195079	57496	64246100
Living in residential institution	53.13	11.44	29	195107	572	64303024
Drug-induced liver injury	52.89	11.44	40	195096	47603	64255993
Nausea	52.32	11.44	1899	193237	783901	63519695
Blood creatinine increased	52.27	11.44	222	194914	135560	64168036
Device expulsion	51.78	11.44	3	195133	21133	64282463
Liver function test abnormal	51.77	11.44	62	195074	59339	64244257
Intentional product misuse	51.56	11.44	87	195049	72208	64231388
Acute myocardial infarction	51.50	11.44	82	195054	69636	64233960
Cardiogenic shock	51.32	11.44	17	195119	32410	64271186
Circulatory collapse	51.13	11.44	19	195117	33713	64269883
Musculoskeletal chest pain	50.99	11.44	162	194974	21317	64282279
Poisoning	50.98	11.44	4	195132	21875	64281721
Tooth resorption	50.80	11.44	13	195123	19	64303577
Ventricular tachycardia	50.78	11.44	20	195116	34245	64269351
Stevens-Johnson syndrome	50.74	11.44	20	195116	34229	64269367
Sinus tachycardia	50.73	11.44	17	195119	32171	64271425
Parathyroid disorder	50.36	11.44	25	195111	402	64303194
Angioedema	50.27	11.44	68	195068	61753	64241843
Denture wearer	50.16	11.44	16	195120	70	64303526
Haematochezia	50.04	11.44	77	195059	66296	64237300
Alopecia	50.04	11.44	741	194395	164949	64138647
Product prescribing error	49.98	11.44	22	195114	35247	64268349
Dental discomfort	49.89	11.44	23	195113	311	64303285
Haemoglobin decreased	49.42	11.44	366	194770	194697	64108899
White blood cell count increased	49.37	11.44	77	195059	65937	64237659
Lower respiratory tract infection	49.09	11.44	136	195000	94478	64209118
Renal tubular necrosis	48.93	11.44	5	195131	22105	64281491
Drug dependence	48.46	11.44	20	195116	33292	64270304
Hypersensitivity	48.17	11.44	372	194764	196080	64107516
Arthritis	48.13	11.44	425	194711	83389	64220207
Pulmonary oedema	47.96	11.44	104	195032	78570	64225026
Vitamin D abnormal	47.68	11.44	17	195119	111	64303485
Abnormal behaviour	47.61	11.44	21	195115	33601	64269995
Blood pressure increased	47.02	11.44	317	194819	172235	64131361
Anxiety	46.80	11.44	390	194746	202259	64101337
Blood phosphorus decreased	46.68	11.44	71	195065	5634	64297962
Shock	46.59	11.44	29	195107	38211	64265385
Hypoaesthesia	46.35	11.44	633	194503	138475	64165121
Osteoporosis	46.06	11.44	250	194886	41830	64261766
Jaw fracture	45.86	11.44	49	195087	2725	64300871
Respiratory depression	45.48	11.44	8	195128	23435	64280161
Status epilepticus	45.20	11.44	6	195130	21657	64281939
Coagulopathy	45.10	11.44	20	195116	31900	64271696
Drug ineffective for unapproved indication	44.79	11.44	19	195117	31114	64272482
Oral cavity fistula	44.72	11.44	27	195109	649	64302947
Polymyalgia rheumatica	44.70	11.44	53	195083	3306	64300290
Hand fracture	44.70	11.44	64	195072	4810	64298786
Right ventricular failure	44.68	11.44	6	195130	21465	64282131
Extrapyramidal disorder	44.39	11.44	4	195132	19548	64284048
Blood pressure fluctuation	44.29	11.44	55	195081	51816	64251780
Spinal operation	44.19	11.44	72	195064	6061	64297535
Hypervolaemia	43.99	11.44	31	195105	38254	64265342
Spinal deformity	43.80	11.44	29	195107	822	64302774
Medication error	43.70	11.44	52	195084	49914	64253682
Hyperparathyroidism secondary	43.63	11.44	44	195092	2286	64301310
Haematocrit decreased	43.55	11.44	61	195075	54594	64249002
Bronchopulmonary aspergillosis	43.07	11.44	4	195132	19081	64284515
Accidental overdose	42.93	11.44	24	195112	33533	64270063
Cytokine release syndrome	42.92	11.44	6	195130	20823	64282773
Hyperhidrosis	42.87	11.44	213	194923	124707	64178889
Agranulocytosis	42.56	11.44	32	195104	38197	64265399
Pulmonary arterial hypertension	42.49	11.44	12	195124	25355	64278241
C-reactive protein increased	42.44	11.44	146	194990	94763	64208833
Mouth swelling	42.42	11.44	64	195072	5043	64298553
Pancreatitis	42.26	11.44	72	195064	59535	64244061
Heart rate increased	41.99	11.44	155	194981	98520	64205076
Radius fracture	41.98	11.44	50	195086	3134	64300462
Tachypnoea	41.93	11.44	14	195122	26557	64277039
Blood parathyroid hormone abnormal	41.90	11.44	21	195115	345	64303251
Liver injury	41.90	11.44	19	195117	29913	64273683
Palliative care	41.80	11.44	26	195110	660	64302936
Hemiparesis	41.65	11.44	19	195117	29808	64273788
Osteoarthritis	41.60	11.44	331	194805	63005	64240591
Flushing	41.59	11.44	112	195024	78536	64225060
Product quality issue	41.58	11.44	19	195117	29780	64273816
Dyskinesia	41.30	11.44	35	195101	39353	64264243
Oral infection	41.30	11.44	61	195075	4716	64298880
Pneumocystis jirovecii pneumonia	41.16	11.44	16	195120	27618	64275978
Abdominal discomfort	41.14	11.44	353	194783	181969	64121627
Deep vein thrombosis	41.07	11.44	171	194965	105011	64198585
Transplant rejection	41.06	11.44	3	195133	17398	64286198
Torsade de pointes	40.95	11.44	3	195133	17360	64286236
Bone marrow failure	40.78	11.44	51	195085	47901	64255695
Acute myeloid leukaemia	40.74	11.44	16	195120	27447	64276149
Haematoma	40.59	11.44	48	195088	46202	64257394
Melaena	40.48	11.44	62	195074	53486	64250110
Parathyroidectomy	40.31	11.44	17	195119	183	64303413
Injury	40.28	11.44	67	195069	55925	64247671
No adverse event	40.18	11.44	18	195118	28543	64275053
Noninfective gingivitis	39.95	11.44	33	195103	1321	64302275
Therapeutic response decreased	39.86	11.44	60	195076	52128	64251468
Staphylococcal infection	38.96	11.44	58	195078	50620	64252976
Feeling abnormal	38.96	11.44	594	194542	133008	64170588
Injection site erythema	38.83	11.44	99	195037	70701	64232895
Paraesthesia oral	38.75	11.44	107	195029	13024	64290572
Bone swelling	38.73	11.44	31	195105	1186	64302410
Fluid retention	38.69	11.44	76	195060	59530	64244066
Hormone-refractory prostate cancer	38.68	11.44	20	195116	352	64303244
Osteoporotic fracture	38.65	11.44	51	195085	3547	64300049
Infection	38.63	11.44	365	194771	184515	64119081
Diarrhoea	38.35	11.44	1792	193344	720912	63582684
Hepatic failure	38.28	11.44	68	195068	55326	64248270
Tubulointerstitial nephritis	38.27	11.44	23	195113	30886	64272710
Oral surgery	38.22	11.44	28	195108	937	64302659
Disorientation	38.16	11.44	69	195067	55759	64247837
Aspergillus infection	38.15	11.44	3	195133	16376	64287220
Cyanosis	38.01	11.44	10	195126	22145	64281451
Red blood cell sedimentation rate abnormal	37.94	11.44	3	195133	16303	64287293
Oedema peripheral	37.90	11.44	430	194706	209887	64093709
Nerve compression	37.64	11.44	75	195061	7386	64296210
Blood urea increased	37.51	11.44	47	195089	44106	64259490
Psoriasis	37.25	11.44	103	195033	71600	64231996
Diabetic ketoacidosis	37.24	11.44	22	195114	29823	64273773
Type 2 diabetes mellitus	37.21	11.44	29	195107	33991	64269605
Hallucination, auditory	37.05	11.44	4	195132	16935	64286661
Acute respiratory failure	36.62	11.44	59	195077	49875	64253721
Pulmonary hypertension	36.56	11.44	46	195090	43093	64260503
Restlessness	36.32	11.44	40	195096	39745	64263851
Injection site reaction	36.27	11.44	53	195083	46611	64256985
Respiratory rate increased	36.12	11.44	6	195130	18325	64285271
Adverse reaction	36.08	11.44	75	195061	7612	64295984
Bone graft	36.06	11.44	23	195113	611	64302985
Onychoclasis	35.96	11.44	56	195080	4536	64299060
Metastases to skin	35.94	11.44	32	195104	1420	64302176
Device failure	35.94	11.44	63	195073	5629	64297967
Jaundice	35.88	11.44	57	195079	48455	64255141
Pneumonia aspiration	35.59	11.44	79	195057	59192	64244404
Disease recurrence	35.56	11.44	26	195110	31484	64272112
Leukocytosis	35.50	11.44	37	195099	37703	64265893
Renal injury	35.45	11.44	3	195133	15426	64288170
Menopausal symptoms	35.36	11.44	33	195103	1557	64302039
Obstructive airways disorder	35.24	11.44	13	195123	23172	64280424
Vitamin D deficiency	35.23	11.44	96	195040	11596	64292000
Cancer pain	34.86	11.44	53	195083	4204	64299392
PIK3CA-activated mutation	34.81	11.44	21	195115	504	64303092
Asthma	34.63	11.44	159	194977	95066	64208530
Musculoskeletal disorder	34.54	11.44	126	195010	17780	64285816
Withdrawal syndrome	34.34	11.44	14	195122	23478	64280118
Ataxia	34.22	11.44	12	195124	22072	64281524
Hallucination, visual	34.06	11.44	21	195115	27813	64275783
Hypothermia	34.00	11.44	9	195127	19847	64283749
Haemodynamic instability	33.99	11.44	3	195133	14909	64288687
Bone giant cell tumour malignant	33.63	11.44	7	195129	0	64303596
Irritability	33.48	11.44	37	195099	36709	64266887
Parathyroid tumour malignant	33.32	11.44	10	195126	34	64303562
Angina pectoris	33.31	11.44	53	195083	45028	64258568
Hepatitis	33.29	11.44	54	195082	45528	64258068
Paranoia	33.02	11.44	5	195131	16347	64287249
Pancreatitis acute	32.99	11.44	49	195087	42806	64260790
Angina unstable	32.96	11.44	4	195132	15463	64288133
Gingival operation	32.66	11.44	11	195125	59	64303537
Premature delivery	32.64	11.44	8	195128	18581	64285015
Upper gastrointestinal haemorrhage	32.60	11.44	35	195101	35185	64268411
Swelling	32.33	11.44	319	194817	159899	64143697
Sinusitis	32.26	11.44	284	194852	145644	64157952
Gingival erythema	32.15	11.44	20	195116	508	64303088
Cataract operation	32.04	11.44	48	195088	3758	64299838
Shock haemorrhagic	31.99	11.44	6	195130	16785	64286811
Cognitive disorder	31.80	11.44	75	195061	55012	64248584
Muscle spasticity	31.66	11.44	6	195130	16663	64286933
Intervertebral disc protrusion	31.58	11.44	133	195003	20058	64283538
Prescribed overdose	31.58	11.44	11	195125	20320	64283276
Lymphoedema	31.53	11.44	83	195053	9822	64293774
Prostate cancer	31.44	11.44	131	195005	19664	64283932
Haemoptysis	31.44	11.44	63	195073	48985	64254611
Hyperglycaemia	31.35	11.44	88	195048	60880	64242716
Cardiac failure	31.34	11.44	253	194883	132120	64171476
Drug resistance	31.27	11.44	36	195100	35066	64268530
Dental prosthesis user	30.84	11.44	9	195127	27	64303569
Hepatocellular injury	30.83	11.44	56	195080	45179	64258417
Pseudomonas infection	30.82	11.44	8	195128	17875	64285721
Haemorrhage intracranial	30.67	11.44	17	195119	23867	64279729
Myoclonus	30.66	11.44	19	195117	25099	64278497
Acidosis	30.59	11.44	8	195128	17787	64285809
Bone fissure	30.58	11.44	13	195123	143	64303453
Mastectomy	30.43	11.44	25	195111	993	64302603
Dental prosthesis placement	30.38	11.44	8	195128	14	64303582
Aphasia	30.31	11.44	48	195088	40858	64262738
Pallor	30.19	11.44	44	195092	38737	64264859
Peri-implantitis	30.13	11.44	9	195127	30	64303566
Intercepted medication error	30.12	11.44	22	195114	733	64302863
Red blood cell sedimentation rate increased	30.09	11.44	30	195106	31205	64272391
Hepatic encephalopathy	30.07	11.44	13	195123	21053	64282543
Periodontal disease	29.97	11.44	31	195105	1660	64301936
Sinus bradycardia	29.82	11.44	16	195120	22877	64280719
Dysstasia	29.64	11.44	144	194992	23071	64280525
Oral discomfort	29.41	11.44	73	195063	8333	64295263
Muscle tightness	29.33	11.44	87	195049	11028	64292568
Delusion	29.30	11.44	9	195127	18005	64285591
Calcinosis	29.19	11.44	33	195103	1955	64301641
Haemorrhage	29.15	11.44	132	195004	79219	64224377
Diabetes mellitus inadequate control	29.12	11.44	14	195122	21307	64282289
Abscess oral	29.10	11.44	26	195110	1159	64302437
Back disorder	29.08	11.44	81	195055	9909	64293687
Acute coronary syndrome	29.06	11.44	11	195125	19299	64284297
Hepatic cytolysis	29.06	11.44	4	195132	14045	64289551
Ulna fracture	28.82	11.44	24	195112	972	64302624
Haemodialysis	28.75	11.44	8	195128	17069	64286527
Weight bearing difficulty	28.56	11.44	38	195098	2665	64300931
Urinary tract infection	28.40	11.44	909	194227	230687	64072909
Hypokalaemia	28.40	11.44	234	194902	121669	64181927
Haemophagocytic lymphohistiocytosis	28.28	11.44	9	195127	17600	64285996
Anuria	28.21	11.44	11	195125	18953	64284643
Hypoaesthesia oral	28.09	11.44	88	195048	11492	64292104
Exostosis	27.82	11.44	87	195049	11351	64292245
Decreased immune responsiveness	27.78	11.44	49	195087	4399	64299197
Altered state of consciousness	27.59	11.44	45	195091	37857	64265739
Rehabilitation therapy	27.52	11.44	28	195108	1470	64302126
Adverse event	27.38	11.44	209	194927	39280	64264316
Metastases to meninges	27.35	11.44	38	195098	2777	64300819
COVID-19	27.27	11.44	103	195033	65037	64238559
Posterior reversible encephalopathy syndrome	27.13	11.44	18	195118	22928	64280668
Cholesteatoma	27.06	11.44	11	195125	107	64303489
Bronchospasm	27.03	11.44	16	195120	21666	64281930
Parathyroid tumour	26.98	11.44	10	195126	74	64303522
Unevaluable event	26.93	11.44	252	194884	50237	64253359
Hyperthermia	26.71	11.44	7	195129	15543	64288053
Depression	26.63	11.44	392	194744	182899	64120697
Hip surgery	26.48	11.44	35	195101	2438	64301158
Hungry bone syndrome	26.45	11.44	12	195124	156	64303440
Forearm fracture	26.44	11.44	17	195119	458	64303138
Acute hepatic failure	26.41	11.44	24	195112	26088	64277508
Dizziness	26.40	11.44	1049	194087	429114	63874482
Device fastener issue	26.32	11.44	7	195129	13	64303583
Ankle fracture	26.29	11.44	101	195035	14609	64288987
Vitamin D increased	26.28	11.44	17	195119	463	64303133
Abdominal lymphadenopathy	26.26	11.44	24	195112	1102	64302494
Osteolysis	25.99	11.44	37	195099	2766	64300830
Kyphosis	25.83	11.44	34	195102	2359	64301237
Photophobia	25.78	11.44	10	195126	17283	64286313
Activated partial thromboplastin time prolonged	25.73	11.44	4	195132	12827	64290769
Metaphyseal corner fracture	25.65	11.44	8	195128	32	64303564
Nightmare	25.46	11.44	16	195120	20977	64282619
Rash macular	25.43	11.44	140	194996	23545	64280051
Adnexa uteri mass	25.39	11.44	14	195122	282	64303314
Subarachnoid haemorrhage	25.35	11.44	12	195124	18426	64285170
Ascites	25.33	11.44	99	195037	61902	64241694
Myocardial ischaemia	25.20	11.44	20	195116	23231	64280365
Brain oedema	25.19	11.44	18	195118	22057	64281539
Pathogen resistance	24.95	11.44	4	195132	12539	64291057
Limb discomfort	24.88	11.44	154	194982	27021	64276575
Progressive multifocal leukoencephalopathy	24.86	11.44	12	195124	18220	64285376
Bone resorption test abnormal	24.68	11.44	6	195130	6	64303590
Immune system disorder	24.55	11.44	72	195064	9069	64294527
Lung neoplasm malignant	24.54	11.44	129	195007	21319	64282277
Device dislocation	24.52	11.44	17	195119	21161	64282435
Rectal haemorrhage	24.44	11.44	100	195036	61717	64241879
Bone formation increased	24.24	11.44	9	195127	67	64303529
Thrombotic microangiopathy	24.22	11.44	10	195126	16645	64286951
Osteocalcin decreased	24.21	11.44	6	195130	7	64303589
Rales	24.07	11.44	8	195128	15221	64288375
Oral neoplasm benign	24.02	11.44	5	195131	0	64303596
Calcium ionised abnormal	24.02	11.44	5	195131	0	64303596
Myelosuppression	23.99	11.44	22	195114	23808	64279788
Therapy non-responder	23.98	11.44	110	195026	65789	64237807
Nasopharyngitis	23.96	11.44	433	194703	195640	64107956
Transaminases increased	23.95	11.44	63	195073	44531	64259065
Rash papular	23.93	11.44	109	195027	17004	64286592
Hepatitis cholestatic	23.90	11.44	4	195132	12151	64291445
Nasal congestion	23.90	11.44	96	195040	59562	64244034
Injection site pruritus	23.89	11.44	49	195087	37777	64265819
Blood cholesterol increased	23.83	11.44	244	194892	49822	64253774
Bone deformity	23.75	11.44	13	195123	258	64303338
Root canal infection	23.66	11.44	13	195123	260	64303336
Anger	23.63	11.44	9	195127	15732	64287864
Bone sequestrum	23.55	11.44	23	195113	1149	64302447
Bacteraemia	23.54	11.44	28	195108	26883	64276713
Bone cancer	23.43	11.44	26	195110	1509	64302087
Gingival injury	23.28	11.44	7	195129	24	64303572
Atelectasis	23.18	11.44	29	195107	27237	64276359
Obesity	23.16	11.44	17	195119	20545	64283051
Proteinuria	23.04	11.44	30	195106	27693	64275903
Basal cell carcinoma	23.02	11.44	36	195100	30802	64272794
Blood alkaline phosphatase decreased	22.92	11.44	26	195110	1546	64302050
Disturbance in attention	22.85	11.44	57	195079	41017	64262579
Bone fistula	22.85	11.44	9	195127	80	64303516
Parathyroid tumour benign	22.82	11.44	18	195118	674	64302922
Subdural haematoma	22.66	11.44	31	195105	28023	64275573
Lower gastrointestinal haemorrhage	22.60	11.44	7	195129	13932	64289664
Haematuria	22.56	11.44	100	195036	60371	64243225
Cerebral haemorrhage	22.56	11.44	79	195057	51011	64252585
Presyncope	22.55	11.44	45	195091	35044	64268552
Dementia	22.47	11.44	123	195013	20643	64282953
Pulmonary haemorrhage	22.33	11.44	6	195130	13103	64290493
Akathisia	22.17	11.44	4	195132	11506	64292090
Hepatic lesion	21.90	11.44	52	195084	5772	64297824
Nephropathy toxic	21.73	11.44	13	195123	17501	64286095
Tartrate-resistant acid phosphatase increased	21.68	11.44	5	195131	3	64303593
Vertebroplasty	21.66	11.44	12	195124	244	64303352
Muscle rigidity	21.63	11.44	13	195123	17460	64286136
Anaemia	21.62	11.44	931	194205	377749	63925847
Gingival ulceration	21.57	11.44	19	195117	831	64302765
Hepatic steatosis	21.48	11.44	38	195098	30969	64272627
Quality of life decreased	21.46	11.44	62	195074	7744	64295852
Heart rate irregular	21.44	11.44	31	195105	27382	64276214
Gamma-glutamyltransferase increased	21.43	11.44	75	195061	48435	64255161
Hypovolaemia	21.41	11.44	10	195126	15476	64288120
Dysgeusia	21.31	11.44	227	194909	46820	64256776
Breast cancer recurrent	20.93	11.44	32	195104	2551	64301045
Trismus	20.91	11.44	46	195090	4855	64298741
Sudden death	20.89	11.44	18	195118	20078	64283518
Inappropriate antidiuretic hormone secretion	20.80	11.44	22	195114	22267	64281329
Cholestasis	20.76	11.44	68	195068	44804	64258792
Pulmonary congestion	20.72	11.44	25	195111	23855	64279741
Hypophosphatasia	20.72	11.44	7	195129	38	64303558
Degenerative bone disease	20.57	11.44	7	195129	39	64303557
Tricuspid valve incompetence	20.56	11.44	13	195123	16990	64286606
Lichen planus	20.52	11.44	30	195106	2298	64301298
Creatinine renal clearance decreased	20.43	11.44	9	195127	14412	64289184
Atrioventricular block complete	20.42	11.44	9	195127	14409	64289187
Acetabulum fracture	20.40	11.44	15	195121	505	64303091
Parkinsonism	20.31	11.44	9	195127	14364	64289232
Traumatic fracture	20.31	11.44	18	195118	794	64302802
Hepatomegaly	20.29	11.44	13	195123	16869	64286727
Pollakiuria	20.27	11.44	164	194972	31366	64272230
Anaphylactic shock	20.26	11.44	38	195098	30290	64273306
Hair disorder	20.16	11.44	19	195117	908	64302688
Neutrophil count increased	20.15	11.44	28	195108	25146	64278450
Drug level decreased	20.10	11.44	5	195131	11498	64292098
Rash maculo-papular	19.91	11.44	74	195062	46952	64256644
Metastases to neck	19.86	11.44	6	195130	21	64303575
Prostate cancer recurrent	19.60	11.44	17	195119	728	64302868
Scab	19.57	11.44	66	195070	8956	64294640
Caesarean section	19.51	11.44	5	195131	11269	64292327
Catheter site injury	19.37	11.44	9	195127	124	64303472
Oliguria	19.26	11.44	10	195126	14566	64289030
Productive cough	19.17	11.44	136	195000	73067	64230529
Lung infiltration	19.07	11.44	21	195115	20868	64282728
Medial tibial stress syndrome	18.99	11.44	9	195127	130	64303466
Triple negative breast cancer	18.98	11.44	8	195128	86	64303510
Mitral valve incompetence	18.89	11.44	30	195106	25508	64278088
Coordination abnormal	18.71	11.44	11	195125	14953	64288643
Bradyphrenia	18.71	11.44	3	195133	9403	64294193
Oligodipsia	18.50	11.44	6	195130	28	64303568
Bone marrow oedema	18.46	11.44	20	195116	1130	64302466
Cholecystitis chronic	18.39	11.44	3	195133	9284	64294312
Cardiomegaly	18.31	11.44	27	195109	23657	64279939
Epilepsy	18.29	11.44	47	195089	33484	64270112
Electrocardiogram QRS complex prolonged	18.27	11.44	3	195133	9241	64294355
Pain of skin	18.26	11.44	67	195069	9480	64294116
Oral disorder	18.25	11.44	64	195072	8857	64294739
Atrial flutter	18.23	11.44	19	195117	19361	64284235
Macule	18.19	11.44	29	195107	2397	64301199
Product administration error	18.15	11.44	35	195101	27608	64275988
Vision blurred	18.13	11.44	180	194956	90136	64213460
Myelodysplastic syndrome	18.04	11.44	35	195101	27544	64276052
Hyperammonaemia	17.91	11.44	4	195132	9900	64293696
Prostatic specific antigen decreased	17.90	11.44	7	195129	61	64303535
Vertebral lesion	17.85	11.44	13	195123	431	64303165
Respiratory acidosis	17.78	11.44	4	195132	9851	64293745
Carcinoembryonic antigen increased	17.78	11.44	25	195111	1848	64301748
Nail disorder	17.76	11.44	62	195074	8562	64295034
Irritable bowel syndrome	17.72	11.44	56	195080	37313	64266283
Blood pressure systolic increased	17.72	11.44	83	195053	49370	64254226
Aspiration	17.71	11.44	15	195121	16870	64286726
Toxic encephalopathy	17.68	11.44	4	195132	9811	64293785
Osteosclerosis	17.53	11.44	35	195101	3451	64300145
Hypotonia	17.53	11.44	6	195130	11206	64292390
Thyroid operation	17.53	11.44	9	195127	156	64303440
Duodenal ulcer	17.51	11.44	11	195125	14424	64289172
Metastases to bladder	17.31	11.44	10	195126	221	64303375
Therapeutic product effect incomplete	17.30	11.44	215	194921	103267	64200329
Blood glucose decreased	17.26	11.44	27	195109	23096	64280500
Cough	17.20	11.44	743	194393	301405	64002191
Chemotherapy	17.19	11.44	22	195114	1485	64302111
Diffuse large B-cell lymphoma	17.17	11.44	5	195131	10356	64293240
Macroenzyme creatine kinase	17.13	11.44	5	195131	15	64303581
Failure to anastomose	17.11	11.44	10	195126	226	64303370
Extraskeletal ossification	17.05	11.44	7	195129	70	64303526
CYP3A4 polymorphism	17.05	11.44	7	195129	70	64303526
Myopathy	17.01	11.44	17	195119	17663	64285933
Troponin increased	17.00	11.44	13	195123	15386	64288210
Breath sounds abnormal	16.98	11.44	7	195129	11662	64291934
Metastases to soft tissue	16.96	11.44	12	195124	380	64303216
Speech disorder	16.95	11.44	82	195054	48359	64255237
Clavicle fracture	16.92	11.44	36	195100	3713	64299883
Oral mucosal erythema	16.92	11.44	23	195113	1646	64301950
Sleep apnoea syndrome	16.91	11.44	41	195095	29791	64273805
Colitis	16.87	11.44	106	195030	58568	64245028
Bone scan abnormal	16.84	11.44	9	195127	170	64303426
Blood creatinine abnormal	16.78	11.44	38	195098	4089	64299507
Erysipelas	16.76	11.44	63	195073	9018	64294578
Fibula fracture	16.74	11.44	32	195104	3056	64300540
Onychalgia	16.69	11.44	16	195120	781	64302815
Dental cyst	16.66	11.44	5	195131	17	64303579
Vertebral wedging	16.66	11.44	5	195131	17	64303579
Body temperature increased	16.66	11.44	56	195080	36610	64266986
Acute generalised exanthematous pustulosis	16.66	11.44	11	195125	14047	64289549
Hyperbilirubinaemia	16.56	11.44	24	195112	21181	64282415
Drug eruption	16.55	11.44	55	195081	36081	64267515
Facial pain	16.47	11.44	57	195079	7838	64295758
Splenomegaly	16.46	11.44	18	195118	17943	64285653
Hypercalcaemic nephropathy	16.45	11.44	4	195132	4	64303592
Diverticulitis	16.41	11.44	184	194952	38434	64265162
Patella fracture	16.39	11.44	22	195114	1556	64302040
Allergy to plants	16.33	11.44	14	195122	590	64303006
Skin haemorrhage	16.21	11.44	60	195076	8525	64295071
Erectile dysfunction	16.19	11.44	9	195127	12618	64290978
Brain injury	16.17	11.44	5	195131	9960	64293636
Lipase increased	16.10	11.44	12	195124	14390	64289206
Ileus	16.04	11.44	28	195108	22938	64280658
Palpitations	16.03	11.44	221	194915	104267	64199329
Parathyroid gland operation	16.03	11.44	5	195131	20	64303576
Epistaxis	15.99	11.44	205	194931	97926	64205670
Metastases to peritoneum	15.94	11.44	34	195102	3513	64300083
Hypercalciuria	15.89	11.44	12	195124	421	64303175
VIth nerve paresis	15.82	11.44	8	195128	134	64303462
Device malfunction	15.79	11.44	18	195118	17615	64285981
Gingival discolouration	15.74	11.44	9	195127	195	64303401
Electrolyte imbalance	15.69	11.44	33	195103	25210	64278386
Spinal disorder	15.68	11.44	60	195076	8662	64294934
Cardiac failure chronic	15.66	11.44	4	195132	9037	64294559
Migraine	15.66	11.44	118	195018	62559	64241037
Wrong technique in product usage process	15.64	11.44	280	194856	64694	64238902
Platelet count decreased	15.61	11.44	387	194749	167324	64136272
Ventricular extrasystoles	15.59	11.44	18	195118	17511	64286085
Chronic leukaemia	15.57	11.44	4	195132	6	64303590
Chromaturia	15.40	11.44	28	195108	22583	64281013
Rotator cuff syndrome	15.38	11.44	75	195061	12032	64291564
Euthanasia	15.37	11.44	6	195130	52	64303544
Blood pressure abnormal	15.28	11.44	85	195051	14350	64289246
Colitis ulcerative	15.26	11.44	29	195107	22999	64280597
Hepatic function abnormal	15.18	11.44	123	195013	64190	64239406
Sputum discoloured	15.17	11.44	19	195117	17837	64285759
Lip exfoliation	15.17	11.44	13	195123	548	64303048
Blood pressure systolic decreased	15.09	11.44	4	195132	8816	64294780
Immune thrombocytopenia	15.06	11.44	14	195122	15052	64288544
Wisdom teeth removal	15.02	11.44	11	195125	368	64303228
Treatment noncompliance	14.99	11.44	74	195062	43408	64260188
Clostridium difficile colitis	14.97	11.44	38	195098	27185	64276411
Generalised oedema	14.95	11.44	25	195111	20828	64282768
Burning sensation	14.93	11.44	222	194914	49442	64254154
Polyneuropathy in malignant disease	14.92	11.44	8	195128	152	64303444
Injection site haemorrhage	14.87	11.44	32	195104	24246	64279350
Blood pressure diastolic decreased	14.85	11.44	28	195108	22273	64281323
Hypocalcaemic seizure	14.82	11.44	5	195131	27	64303569
Skin sensitisation	14.78	11.44	15	195121	785	64302811
Sense of oppression	14.76	11.44	20	195116	1427	64302169
Skin necrosis	14.70	11.44	13	195123	14316	64289280
Skin disorder	14.68	11.44	138	194998	27542	64276054
Encephalitis	14.68	11.44	10	195126	12561	64291035
Pulmonary embolism	14.65	11.44	334	194802	146022	64157574
Fear	14.63	11.44	24	195112	20147	64283449
Blood culture positive	14.59	11.44	3	195133	7865	64295731
Cholecystitis	14.59	11.44	23	195113	19613	64283983
Mental disorder	14.48	11.44	37	195099	26408	64277188
Febrile bone marrow aplasia	14.47	11.44	8	195128	11247	64292349
Electrocardiogram QT prolonged	14.46	11.44	162	194974	79286	64224310
Pleural neoplasm	14.42	11.44	9	195127	230	64303366
Macular degeneration	14.41	11.44	44	195092	5666	64297930
Diabetic endorgan damage	14.41	11.44	3	195133	0	64303596
Injection site movement impairment	14.41	11.44	3	195133	0	64303596
Periodontal operation	14.41	11.44	3	195133	0	64303596
Bone metabolism biochemical marker increased	14.41	11.44	3	195133	0	64303596
Serum procollagen type I N-terminal propeptide decreased	14.41	11.44	3	195133	0	64303596
Tuberculosis	14.40	11.44	11	195125	13027	64290569
Therapy interrupted	14.38	11.44	24	195112	20012	64283584
Intramedullary rod insertion	14.30	11.44	8	195128	166	64303430
Fistula	14.27	11.44	63	195073	9698	64293898
Eosinophil count increased	14.24	11.44	13	195123	14099	64289497
Hepatic necrosis	14.21	11.44	4	195132	8469	64295127
Malocclusion	13.97	11.44	7	195129	115	64303481
Lip and/or oral cavity cancer	13.96	11.44	12	195124	508	64303088
Immobile	13.94	11.44	45	195091	5970	64297626
Catatonia	13.94	11.44	3	195133	7617	64295979
Ear disorder	13.87	11.44	30	195106	3130	64300466
Dermatitis exfoliative	13.83	11.44	7	195129	10345	64293251
Upper respiratory tract infection	13.81	11.44	147	194989	72638	64230958
Bone cancer metastatic	13.80	11.44	8	195128	178	64303418
Platelet count increased	13.79	11.44	22	195114	18674	64284922
Gait inability	13.77	11.44	192	194944	42176	64261420
Neurotoxicity	13.76	11.44	40	195096	27364	64276232
Arteriosclerosis coronary artery	13.75	11.44	16	195120	15513	64288083
Vulvovaginal rash	13.73	11.44	6	195130	71	64303525
Mucosal pain	13.71	11.44	4	195132	12	64303584
Hypovolaemic shock	13.63	11.44	7	195129	10259	64293337
Malpositioned teeth	13.61	11.44	5	195131	36	64303560
Mood altered	13.58	11.44	17	195119	15962	64287634
Gastritis erosive	13.57	11.44	6	195130	9589	64294007
International normalised ratio decreased	13.56	11.44	3	195133	7475	64296121
Vascular fragility	13.55	11.44	7	195129	123	64303473
Polyuria	13.54	11.44	11	195125	12632	64290964
Bacterial sepsis	13.51	11.44	3	195133	7454	64296142
Vipoma	13.47	11.44	4	195132	13	64303583
Ventricular arrhythmia	13.40	11.44	3	195133	7412	64296184
Pruritus	13.36	11.44	1108	194028	311292	63992304
Visual acuity reduced	13.35	11.44	40	195096	27101	64276495
Motor dysfunction	13.34	11.44	9	195127	11364	64292232
Tumour lysis syndrome	13.31	11.44	24	195112	19416	64284180
Urine abnormality	13.26	11.44	3	195133	7359	64296237
Brachiocephalic vein thrombosis	13.25	11.44	7	195129	129	64303467
Hypertension	13.24	11.44	645	194491	258616	64044980
Skin exfoliation	13.24	11.44	200	194936	44685	64258911
Conjunctivitis	13.17	11.44	26	195110	20328	64283268
Fracture pain	13.16	11.44	10	195126	354	64303242
Hip arthroplasty	13.16	11.44	110	195026	21241	64282355
Hypoaesthesia teeth	13.15	11.44	5	195131	40	64303556
Chronic kidney disease	13.11	11.44	112	195024	57807	64245789
Post procedural haemorrhage	13.09	11.44	11	195125	12420	64291176
Spinal fusion surgery	13.09	11.44	32	195104	3619	64299977
Injection site bruising	13.06	11.44	61	195075	36312	64267284
Tenosynovitis	13.05	11.44	10	195126	11823	64291773
Lymphocyte count decreased	13.05	11.44	71	195065	40628	64262968
Injected limb mobility decreased	13.03	11.44	4	195132	15	64303581
Extradural neoplasm	13.03	11.44	4	195132	15	64303581
Electrocardiogram ST segment elevation	12.99	11.44	3	195133	7256	64296340
Blood phosphorus abnormal	12.97	11.44	9	195127	276	64303320
Jaundice cholestatic	12.94	11.44	5	195131	8665	64294931
Electrocardiogram abnormal	12.92	11.44	13	195123	13468	64290128
Tachyphylaxis	12.91	11.44	9	195127	278	64303318
Blister	12.87	11.44	170	194966	80797	64222799
Atrophic vulvovaginitis	12.87	11.44	17	195119	1184	64302412
Pulmonary tumour thrombotic microangiopathy	12.83	11.44	6	195130	84	64303512
Bladder disorder	12.81	11.44	52	195084	7715	64295881
Ocular hyperaemia	12.80	11.44	31	195105	22533	64281063
Cerebral haematoma	12.80	11.44	3	195133	7182	64296414
Injection site swelling	12.79	11.44	73	195063	41280	64262316
Blood lactate dehydrogenase increased	12.77	11.44	54	195082	33024	64270572
Periprosthetic fracture	12.72	11.44	12	195124	574	64303022
Hypoxic-ischaemic encephalopathy	12.71	11.44	3	195133	7149	64296447
Aplastic anaemia	12.70	11.44	14	195122	13906	64289690
Acute pulmonary oedema	12.69	11.44	12	195124	12797	64290799
Pulmonary fibrosis	12.66	11.44	47	195089	29831	64273765
Giant cell arteritis	12.65	11.44	24	195112	2279	64301317
Carbohydrate antigen 27.29 increased	12.64	11.44	5	195131	45	64303551
Metastases to vagina	12.63	11.44	4	195132	17	64303579
Osteoporosis postmenopausal	12.63	11.44	4	195132	17	64303579
Faeces discoloured	12.60	11.44	38	195098	25691	64277905
Urine output decreased	12.55	11.44	19	195117	16473	64287123
Lymphopenia	12.49	11.44	38	195098	25619	64277977
Blood 1,25-dihydroxycholecalciferol increased	12.45	11.44	4	195132	18	64303578
Breast disorder	12.45	11.44	20	195116	1664	64301932
Colonoscopy	12.44	11.44	20	195116	1665	64301931
Gastroenteritis	12.42	11.44	47	195089	29664	64273932
Staphylococcal bacteraemia	12.41	11.44	8	195128	10347	64293249
Peripheral swelling	12.38	11.44	512	194624	208641	64094955
Arteriosclerosis	12.37	11.44	18	195118	15859	64287737
Osteomalacia	12.37	11.44	18	195118	1373	64302223
Eastern Cooperative Oncology Group performance status worsened	12.36	11.44	17	195119	1231	64302365
Dental paraesthesia	12.34	11.44	3	195133	3	64303593
Retinal operation	12.34	11.44	3	195133	3	64303593
Enteritis	12.34	11.44	11	195125	12066	64291530
Oestradiol abnormal	12.28	11.44	4	195132	19	64303577
Ammonia increased	12.26	11.44	3	195133	6974	64296622
Carpal tunnel decompression	12.24	11.44	11	195125	494	64303102
Leukoencephalopathy	12.23	11.44	3	195133	6964	64296632
Atrioventricular block	12.20	11.44	11	195125	12004	64291592
Affect lability	12.13	11.44	6	195130	8984	64294612
Knee arthroplasty	12.10	11.44	130	195006	26869	64276727
Bronchitis	12.09	11.44	244	194892	108499	64195097
Vertigo	12.05	11.44	248	194888	58763	64244833
Oesophagitis	12.05	11.44	30	195106	21600	64281996
Hyperuricaemia	12.04	11.44	8	195128	10183	64293413
Metastatic neoplasm	11.94	11.44	35	195101	4407	64299189
Atrioventricular block first degree	11.93	11.44	9	195127	10725	64292871
Nail avulsion	11.90	11.44	6	195130	100	64303496
Demyelination	11.89	11.44	3	195133	6831	64296765
Cementoplasty	11.88	11.44	3	195133	4	64303592
Gingival cyst	11.88	11.44	3	195133	4	64303592
Bone operation	11.86	11.44	8	195128	234	64303362
Rash erythematous	11.85	11.44	210	194926	48423	64255173
Sternal fracture	11.83	11.44	23	195113	2224	64301372
Ecchymosis	11.83	11.44	15	195121	14007	64289589
Surgery	11.80	11.44	134	195002	28079	64275517
Hypercalcaemia of malignancy	11.79	11.44	9	195127	321	64303275
Pericardial effusion	11.76	11.44	70	195066	39184	64264412
Cholelithiasis	11.69	11.44	85	195051	45421	64258175
Liver function test increased	11.68	11.44	51	195085	30919	64272677
Cataract	11.67	11.44	219	194917	51043	64252553
Spondylolisthesis	11.67	11.44	26	195110	2768	64300828
Breast cancer female	11.67	11.44	38	195098	5065	64298531
Bone density increased	11.66	11.44	11	195125	526	64303070
Granuloma annulare	11.65	11.44	11	195125	527	64303069
Clostridium difficile infection	11.64	11.44	63	195073	36100	64267496
Hepatotoxicity	11.59	11.44	72	195064	39890	64263706
Blood potassium increased	11.58	11.44	40	195096	25940	64277656
Coronary artery occlusion	11.57	11.44	15	195121	13876	64289720
Abdominal pain upper	11.55	11.44	423	194713	174607	64128989
Neoplasm	11.53	11.44	47	195089	6984	64296612
Enterococcal infection	11.53	11.44	15	195121	13851	64289745
Invasive lobular breast carcinoma	11.53	11.44	11	195125	534	64303062
Urethritis noninfective	11.50	11.44	4	195132	24	64303572

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M05BX04	MUSCULO-SKELETAL SYSTEM DRUGS FOR TREATMENT OF BONE DISEASES DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION Other drugs affecting bone structure and mineralization
MeSH PA	D050071	Bone Density Conservation Agents
FDA MoA	N0000187054	RANK Ligand Blocking Activity
FDA EPC	N0000187055	RANK Ligand Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Drug-induced osteoporosis	indication	14651005
Osteoporosis	indication	64859006	DOID:11476
Postmenopausal osteoporosis	indication	102447009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Tumor necrosis factor ligand superfamily member 11	Cytokine	O14788	TNF11_HUMAN	ANTIBODY BINDING				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D03684	KEGG_DRUG
4030131	VUID
N0000181718	NUI
4030131	VANDF
CHEMBL1237023	ChEMBL_ID
6886	IUPHAR_LIGAND_ID
8653	INN_ID
DB06643	DRUGBANK_ID
4EQZ6YO2HI	UNII
993449	RXNORM
173191	MMSL
27218	MMSL
d07640	MMSL
446321003	SNOMEDCT_US
446457007	SNOMEDCT_US
D000069448	MESH_DESCRIPTOR_UI
C1690432	UMLSCUI
013441	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Prolia	HUMAN PRESCRIPTION DRUG LABEL	1	55513-710	INJECTION	60 mg	SUBCUTANEOUS	BLA	34 sections
Prolia	HUMAN PRESCRIPTION DRUG LABEL	1	55513-710	INJECTION	60 mg	SUBCUTANEOUS	BLA	34 sections
XGEVA	HUMAN PRESCRIPTION DRUG LABEL	1	55513-730	INJECTION	120 mg	SUBCUTANEOUS	BLA	29 sections