All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

denosumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
human origin	4965	615258-40-7

Description:

Molecule	Description
Synonyms: denosumab prolia AMG 162 AMG162	A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

Dose	Unit	Route
0.33	mg	P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
June 1, 2010	FDA	AMGEN
May 26, 2010	EMA	Amgen Europe B.V.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	38447.08	10.40	28108	224860	1074144	89301335
Osteonecrosis of jaw	13777.45	10.40	4869	248099	34234	90341245
Death	6806.44	10.40	7310	245658	449241	89926238
Spinal fracture	3326.01	10.40	1490	251478	20526	90354953
Hypocalcaemia	2501.52	10.40	1527	251441	40841	90334638
Bone pain	2431.18	10.40	1730	251238	60253	90315226
Tooth disorder	2155.17	10.40	1243	251725	29847	90345632
Atypical femur fracture	1906.38	10.40	706	252262	5715	90369764
Pain in jaw	1705.21	10.40	1262	251706	46723	90328756
Tooth extraction	1589.20	10.40	732	252236	10781	90364698
Back pain	1494.45	10.40	2950	250018	314225	90061254
Myalgia	1209.24	10.40	1927	251041	173198	90202281
Drug ineffective	1188.70	10.40	1275	251693	1383023	88992456
Metastases to bone	1052.92	10.40	735	252233	24770	90350709
Pain in extremity	1041.61	10.40	3187	249781	447342	89928137
Fracture	1031.99	10.40	687	252281	21389	90354090
Thoracic vertebral fracture	1027.33	10.40	432	252536	5042	90370437
Occupational exposure to product	1003.80	10.40	345	252623	2186	90373293
Bone density abnormal	959.16	10.40	380	252588	3760	90371719
Bone density decreased	901.80	10.40	577	252391	16768	90358711
Accidental exposure to product	894.90	10.40	824	252144	41542	90333937
Tooth fracture	884.12	10.40	508	252460	12092	90363387
Pemphigus	850.00	10.40	12	252956	326852	90048627
Maternal exposure during pregnancy	834.71	10.40	41	252927	360022	90015457
Femur fracture	800.84	10.40	805	252163	45277	90330202
Lumbar vertebral fracture	800.42	10.40	399	252569	7059	90368420
Spinal compression fracture	786.81	10.40	504	252464	14674	90360805
Infusion related reaction	763.88	10.40	124	252844	416656	89958823
Synovitis	744.16	10.40	44	252924	329708	90045771
Toothache	738.95	10.40	562	252406	21668	90353811
Pathological fracture	724.98	10.40	407	252561	9253	90366226
Systemic lupus erythematosus	723.94	10.40	82	252886	361814	90013665
Product storage error	697.80	10.40	523	252445	19718	90355761
Hip fracture	693.99	10.40	641	252327	32436	90343043
Blood parathyroid hormone increased	677.75	10.40	281	252687	3156	90372323
Arthralgia	651.55	10.40	4050	248918	774472	89601007
Glossodynia	645.82	10.40	72	252896	321707	90053772
Anti-cyclic citrullinated peptide antibody positive	641.62	10.40	3	252965	236430	90139049
Contraindicated product administered	619.44	10.40	81	252887	320058	90055421
Exposure during pregnancy	618.59	10.40	9	252959	238401	90137078
Drug intolerance	613.78	10.40	241	252727	447350	89928129
Hand deformity	610.97	10.40	60	252908	296302	90079177
Exposed bone in jaw	606.78	10.40	248	252720	2678	90372801
Rebound effect	601.98	10.40	357	252611	9027	90366452
Intercepted product administration error	600.46	10.40	182	252786	716	90374763
Pericarditis	591.78	10.40	42	252926	270109	90105370
Helicobacter infection	582.49	10.40	10	252958	226840	90148639
Duodenal ulcer perforation	571.35	10.40	9	252959	221279	90154200
Treatment failure	568.94	10.40	85	252883	303843	90071636
Tooth loss	563.43	10.40	317	252651	7237	90368242
Jaw disorder	560.17	10.40	285	252683	5274	90370205
Breast cancer metastatic	559.83	10.40	408	252560	14724	90360755
Dental care	559.55	10.40	188	252780	1100	90374379
Metastases to liver	550.26	10.40	530	252438	28277	90347202
Dental implantation	546.90	10.40	169	252799	720	90374759
Hepatic enzyme increased	544.88	10.40	165	252803	360571	90014908
Wound	524.83	10.40	104	252864	302876	90072603
Groin pain	520.50	10.40	359	252609	11854	90363625
Condition aggravated	517.65	10.40	540	252428	595005	89780474
Folliculitis	508.86	10.40	13	252955	204340	90171139
Product use issue	483.77	10.40	159	252809	329760	90045719
Toxicity to various agents	461.96	10.40	117	252851	287729	90087750
Bone loss	453.79	10.40	213	252755	3279	90372200
Rheumatoid factor positive	451.75	10.40	5	252963	171645	90203834
Osteomyelitis	444.84	10.40	465	252503	27381	90348098
Psoriatic arthropathy	440.99	10.40	58	252910	228277	90147202
Joint swelling	438.68	10.40	455	252513	502845	89872634
Malignant neoplasm progression	438.02	10.40	940	252028	105930	90269549
Therapeutic product effect decreased	437.46	10.40	117	252851	277454	90098025
Muscle injury	436.96	10.40	12	252956	176642	90198837
Drug hypersensitivity	435.52	10.40	392	252576	463217	89912262
Exostosis of jaw	434.53	10.40	155	252813	1112	90374367
Type 2 diabetes mellitus	416.52	10.40	42	252926	203202	90172277
Neoplasm progression	415.62	10.40	565	252403	43921	90331558
Product use in unapproved indication	404.78	10.40	217	252751	336019	90039460
Loose tooth	397.96	10.40	199	252769	3544	90371935
Abdominal discomfort	388.95	10.40	456	252512	476872	89898607
Atypical fracture	385.18	10.40	131	252837	800	90374679
Blood calcium decreased	385.14	10.40	448	252520	29734	90345745
Swelling	382.07	10.40	364	252604	418694	89956785
Irritable bowel syndrome	379.05	10.40	62	252906	207386	90168093
Liver injury	374.90	10.40	26	252942	170541	90204938
Completed suicide	373.94	10.40	6	252962	145052	90230427
Confusional state	364.44	10.40	325	252643	385880	89989599
Terminal state	363.45	10.40	171	252797	2647	90372832
Compression fracture	361.98	10.40	253	252715	8536	90366943
Wheezing	344.92	10.40	117	252851	237963	90137516
Dental caries	339.34	10.40	270	252698	11127	90364352
Foot fracture	329.62	10.40	389	252579	26217	90349262
Fall	327.25	10.40	2383	250585	479427	89896052
Osteonecrosis	314.12	10.40	377	252591	25864	90349615
C-reactive protein abnormal	313.83	10.40	9	252959	127420	90248059
Bone disorder	311.54	10.40	353	252615	22767	90352712
Injury	296.42	10.40	91	252877	197258	90178221
Lower respiratory tract infection	295.41	10.40	166	252802	250493	90124986
Hypersensitivity	289.86	10.40	516	252452	454161	89921318
Swollen joint count increased	280.91	10.40	6	252962	111200	90264279
Weight increased	278.54	10.40	461	252507	417466	89958013
Intentional product use issue	265.27	10.40	137	252831	216755	90158724
Multiple fractures	264.51	10.40	217	252751	9345	90366134
Metastases to lung	257.12	10.40	268	252700	15723	90359756
Osteonecrosis of external auditory canal	255.02	10.40	66	252902	118	90375361
Pelvic fracture	253.60	10.40	260	252708	14959	90360520
Facet joint syndrome	249.74	10.40	5	252963	98384	90277095
Breast cancer	249.68	10.40	498	252470	53263	90322216
Blister	249.62	10.40	207	252761	254791	90120688
Discomfort	247.84	10.40	240	252728	274095	90101384
Arthropathy	247.72	10.40	400	252568	365842	90009637
Intentional overdose	245.64	10.40	3	252965	93831	90281648
Wrist fracture	239.02	10.40	255	252713	15369	90360110
Investigation	237.55	10.40	107	252861	1490	90373989
Blood calcium increased	236.20	10.40	225	252743	11833	90363646
Endodontic procedure	235.49	10.40	137	252831	3338	90372141
Overdose	234.52	10.40	74	252894	157635	90217844
Fibromyalgia	229.80	10.40	146	252822	206123	90169356
Neutropenia	225.79	10.40	1230	251738	223674	90151805
Rheumatoid arthritis	223.42	10.40	420	252548	362194	90013285
Hospitalisation	222.76	10.40	825	252143	127275	90248204
Drug interaction	217.57	10.40	271	252697	276182	90099297
Prescribed overdose	217.07	10.40	14	252954	97611	90277868
Tooth abscess	216.73	10.40	248	252720	16165	90359314
Vomiting	215.72	10.40	1304	251664	786989	89588490
Breast cancer stage III	215.52	10.40	4	252964	84443	90291036
Sinusitis	215.25	10.40	393	252575	342695	90032784
Lip dry	214.42	10.40	18	252950	100937	90274542
Metastases to lymph nodes	213.70	10.40	210	252758	11479	90364000
Drug abuse	205.81	10.40	5	252963	82342	90293137
Jaw operation	201.94	10.40	80	252888	791	90374688
Rib fracture	201.73	10.40	305	252663	26130	90349349
Stress fracture	200.48	10.40	177	252791	8434	90367045
Temporomandibular joint syndrome	199.81	10.40	130	252838	3887	90371592
Gingival disorder	198.12	10.40	129	252839	3862	90371617
Periodontitis	197.32	10.40	127	252841	3726	90371753
Tooth infection	197.25	10.40	262	252706	19908	90355571
Carbohydrate antigen 15-3 increased	193.82	10.40	100	252868	1907	90373572
Sleep disorder due to general medical condition, insomnia type	192.02	10.40	60	252908	128634	90246845
Osteoporotic fracture	191.93	10.40	135	252833	4601	90370878
Dental operation	191.87	10.40	93	252875	1543	90373936
Obesity	191.61	10.40	32	252936	105475	90270004
Spinal pain	191.12	10.40	228	252740	15539	90359940
Hypercalcaemia	184.64	10.40	338	252630	33902	90341577
Gingival pain	183.19	10.40	177	252791	9475	90366004
Oedema	182.27	10.40	174	252794	200121	90175358
Deep vein thrombosis postoperative	182.16	10.40	3	252965	70806	90304673
Tumour marker increased	178.09	10.40	140	252828	5667	90369812
Acute kidney injury	177.83	10.40	394	252574	319993	90055486
Infection	173.85	10.40	480	252488	361614	90013865
Incorrect route of product administration	171.39	10.40	413	252555	50213	90325266
Gingivitis	170.68	10.40	168	252800	9201	90366278
Abscess jaw	170.12	10.40	83	252885	1398	90374081
Hypotension	169.48	10.40	414	252554	324983	90050496
Cystitis	168.52	10.40	488	252480	66230	90309249
Musculoskeletal stiffness	164.28	10.40	365	252603	296167	90079312
Asthma	163.13	10.40	265	252703	241895	90133584
Blood calcium abnormal	161.23	10.40	88	252880	1889	90373590
Metastases to central nervous system	161.09	10.40	221	252747	17321	90358158
Eczema	159.74	10.40	413	252555	52457	90323022
Bedridden	157.78	10.40	182	252786	11966	90363513
Metastases to spine	157.07	10.40	109	252859	3634	90371845
Migraine	155.73	10.40	181	252787	190211	90185268
Grip strength decreased	155.55	10.40	34	252934	92542	90282937
Wound infection	154.51	10.40	52	252916	106350	90269129
Gingival swelling	151.89	10.40	120	252848	4893	90370586
Artificial crown procedure	151.05	10.40	53	252915	360	90375119
Suicide attempt	150.76	10.40	17	252951	75382	90300097
Pulmonary fibrosis	150.18	10.40	56	252912	107447	90268032
Prescribed underdose	149.78	10.40	17	252951	75002	90300477
Nasopharyngitis	148.65	10.40	608	252360	406496	89968983
Pyrexia	148.50	10.40	1157	251811	659328	89716151
Hypophosphataemia	146.87	10.40	194	252774	14660	90360819
Musculoskeletal pain	146.59	10.40	898	252070	170353	90205126
Gingival recession	146.08	10.40	79	252889	1664	90373815
Osteitis	144.71	10.40	104	252864	3669	90371810
Somnolence	142.51	10.40	227	252741	208857	90166622
Tetany	141.87	10.40	89	252879	2495	90372984
Hyperaesthesia teeth	141.80	10.40	85	252883	2192	90373287
Dislocation of vertebra	141.41	10.40	3	252965	55965	90319514
Hypercholesterolaemia	140.20	10.40	53	252915	100839	90274640
Delirium	136.60	10.40	60	252908	104299	90271180
Dyspnoea	135.62	10.40	1692	251276	879263	89496216
Headache	135.08	10.40	1651	251317	861095	89514384
Upper limb fracture	134.46	10.40	227	252741	21351	90354128
Inflammation	134.33	10.40	181	252787	178411	90197068
Joint range of motion decreased	132.79	10.40	110	252858	135533	90239946
Peripheral venous disease	132.79	10.40	35	252933	83886	90291593
Musculoskeletal discomfort	132.37	10.40	222	252746	20769	90354710
Body height decreased	130.59	10.40	164	252804	11785	90363694
Ill-defined disorder	127.64	10.40	199	252769	184692	90190787
Product quality issue	127.59	10.40	32	252936	79293	90296186
Hyperparathyroidism	125.74	10.40	91	252877	3246	90372233
Peripheral swelling	123.65	10.40	663	252305	412443	89963036
Adjustment disorder with depressed mood	123.65	10.40	9	252959	56744	90318735
Influenza like illness	123.60	10.40	499	252469	80112	90295367
C-telopeptide increased	121.14	10.40	28	252940	21	90375458
Dental restoration failure	121.14	10.40	61	252907	1103	90374376
Blepharospasm	120.20	10.40	9	252959	55436	90320043
Vitamin D decreased	119.28	10.40	157	252811	11822	90363657
Femoral neck fracture	119.16	10.40	145	252823	10088	90365391
Abortion spontaneous	116.55	10.40	9	252959	54047	90321432
Neoplasm malignant	116.40	10.40	278	252690	33602	90341877
Pneumonia	116.37	10.40	1179	251789	636880	89738599
PIK3CA-activated mutation	116.30	10.40	60	252908	1144	90374335
Psoriasis	115.99	10.40	145	252823	147609	90227870
White blood cell count decreased	115.60	10.40	831	252137	166278	90209201
Dermatitis	115.59	10.40	216	252752	22004	90353475
Gastrointestinal disorder	115.28	10.40	351	252617	256336	90119143
Bradycardia	114.91	10.40	45	252923	83802	90291677
Tachycardia	114.37	10.40	164	252804	157509	90217970
Bursitis	113.30	10.40	120	252848	131534	90243945
X-ray abnormal	112.59	10.40	3	252965	45421	90330058
Autoimmune disorder	112.30	10.40	37	252931	76707	90298772
Red blood cell sedimentation rate increased	112.09	10.40	45	252923	82550	90292929
Depressed level of consciousness	112.07	10.40	32	252936	72752	90302727
Abdominal pain	111.92	10.40	647	252321	395074	89980405
Mastication disorder	111.30	10.40	75	252893	2381	90373098
Circumstance or information capable of leading to medication error	109.49	10.40	99	252869	4868	90370611
Suicidal ideation	105.65	10.40	37	252931	73818	90301661
Sequestrectomy	105.22	10.40	49	252919	740	90374739
Coma	102.85	10.40	37	252931	72595	90302884
Inappropriate schedule of product administration	102.78	10.40	744	252224	149189	90226290
Fractured sacrum	102.60	10.40	71	252897	2356	90373123
Cardiac arrest	100.37	10.40	87	252881	104848	90270631
Dental cleaning	99.24	10.40	22	252946	10	90375469
Oral pain	98.40	10.40	255	252713	32428	90343051
Lung disorder	98.12	10.40	167	252801	149716	90225763
C-reactive protein increased	97.36	10.40	227	252741	181162	90194317
Night sweats	97.32	10.40	130	252838	128636	90246843
Lactic acidosis	96.91	10.40	13	252955	50450	90325029
Radius fracture	95.89	10.40	84	252884	3960	90371519
Muscle spasms	95.75	10.40	1100	251868	250783	90124696
Wrong technique in product usage process	94.95	10.40	424	252544	71147	90304332
Blood phosphorus decreased	94.94	10.40	92	252876	4942	90370537
Serotonin syndrome	92.09	10.40	3	252965	37884	90337595
Drug-induced liver injury	91.20	10.40	71	252897	90247	90285232
No adverse event	90.69	10.40	38	252930	67944	90307535
Humerus fracture	89.43	10.40	123	252845	9662	90365817
Sleep disorder	88.74	10.40	271	252697	197759	90177720
Anxiety	88.34	10.40	505	252463	309267	90066212
Lupus-like syndrome	88.26	10.40	15	252953	48831	90326648
Rash pruritic	88.09	10.40	458	252510	81756	90293723
Hypertension	87.68	10.40	835	252133	456697	89918782
Seizure	86.83	10.40	185	252783	152444	90223035
Bone erosion	86.02	10.40	21	252947	53000	90322479
Chest pain	85.91	10.40	531	252437	319114	90056365
Road traffic accident	85.11	10.40	105	252863	107521	90267958
Jaw fistula	84.99	10.40	23	252945	53	90375426
Tibia fracture	83.80	10.40	94	252874	5993	90369486
Drug dose omission by device	83.73	10.40	122	252846	10109	90365370
Abdominal pain upper	83.63	10.40	564	252404	332110	90043369
Immobile	83.33	10.40	96	252872	6302	90369177
Febrile neutropenia	82.72	10.40	201	252767	158148	90217331
Tooth erosion	81.92	10.40	36	252932	471	90375008
Musculoskeletal chest pain	81.72	10.40	195	252773	23555	90351924
Multiple sclerosis relapse	80.52	10.40	23	252945	52282	90323197
Joint noise	80.31	10.40	86	252882	5204	90370275
Product dose omission issue	79.95	10.40	1200	251768	290487	90084992
Hypophosphatasia	79.76	10.40	22	252946	56	90375423
Depression	79.42	10.40	502	252466	300099	90075380
Blood parathyroid hormone abnormal	79.34	10.40	29	252939	225	90375254
Injection site reaction	79.14	10.40	84	252884	91996	90283483
Dental necrosis	78.83	10.40	25	252943	118	90375361
Muscle spasticity	78.70	10.40	5	252963	35317	90340162
Drug ineffective for unapproved indication	77.20	10.40	45	252923	66599	90308880
Contusion	76.85	10.40	400	252568	250816	90124663
Liver disorder	76.75	10.40	138	252830	121131	90254348
Dry skin	76.04	10.40	463	252505	87610	90287869
General physical health deterioration	74.15	10.40	634	252334	354481	90020998
Cardio-respiratory arrest	74.04	10.40	42	252926	63098	90312381
Anaphylactic reaction	73.94	10.40	81	252887	87443	90288036
Metabolic acidosis	72.87	10.40	32	252936	55644	90319835
Carcinoembryonic antigen increased	72.81	10.40	57	252911	2293	90373186
Gingival abscess	72.64	10.40	42	252926	1011	90374468
Jaw fracture	72.45	10.40	60	252908	2618	90372861
Metastases to pleura	70.84	10.40	53	252915	1991	90373488
Pulpitis dental	70.62	10.40	41	252927	995	90374484
Unresponsive to stimuli	70.46	10.40	11	252957	38110	90337369
Drug tolerance decreased	70.26	10.40	5	252963	32125	90343354
Feeling abnormal	70.23	10.40	745	252223	166490	90208989
Amnesia	70	10.40	122	252846	108383	90267096
Parathyroid tumour malignant	69.85	10.40	19	252949	45	90375434
Premature delivery	69.83	10.40	12	252956	38750	90336729
Foetal exposure during pregnancy	69.76	10.40	17	252951	42958	90332521
Onychomadesis	69.39	10.40	21	252947	45977	90329502
Intentional self-injury	68.97	10.40	3	252965	29331	90346148
Agitation	68.69	10.40	52	252916	67046	90308433
Metastases to skin	68.68	10.40	53	252915	2087	90373392
Hand fracture	68.39	10.40	90	252878	6775	90368704
Scoliosis	66.86	10.40	102	252866	8805	90366674
Bone lesion	66.63	10.40	86	252882	6351	90369128
Blood cholesterol increased	66.58	10.40	326	252642	207686	90167793
Spinal deformity	66.27	10.40	42	252926	1199	90374280
Dental fistula	66.15	10.40	34	252934	643	90374836
C-reactive protein	65.48	10.40	6	252962	31361	90344118
Traumatic fracture	65.20	10.40	35	252933	726	90374753
Dry mouth	65.14	10.40	278	252690	183781	90191698
Vitamin D abnormal	65.08	10.40	23	252945	160	90375319
Injury associated with device	65.02	10.40	71	252897	4393	90371086
Vitamin D deficiency	64.61	10.40	148	252820	17408	90358071
Medication error	64.43	10.40	85	252883	84567	90290912
Therapeutic response decreased	64.39	10.40	94	252874	89635	90285844
Colitis ulcerative	63.91	10.40	45	252923	60221	90315258
Therapeutic product effect incomplete	63.73	10.40	301	252667	193595	90181884
Tooth resorption	63.49	10.40	17	252951	37	90375442
Hospice care	63.02	10.40	104	252864	9600	90365879
Urinary tract infection	62.78	10.40	1200	251768	304432	90071047
Liver function test increased	62.76	10.40	87	252881	84768	90290711
Therapy non-responder	62.72	10.40	185	252783	136519	90238960
Unevaluable event	62.56	10.40	311	252657	54537	90320942
Epilepsy	62.10	10.40	83	252885	82123	90293356
Dyspepsia	62.02	10.40	313	252655	197847	90177632
Encephalopathy	61.89	10.40	26	252942	46418	90329061
Periodontal disease	60.70	10.40	45	252923	1667	90373812
Cholesteatoma	60.49	10.40	22	252946	168	90375311
Hypoxia	60.06	10.40	68	252900	72331	90303148
Urticaria	59.74	10.40	571	252397	312163	90063316
Menopausal symptoms	59.46	10.40	57	252911	3021	90372458
International normalised ratio increased	59.13	10.40	29	252939	47287	90328192
Parathyroid tumour benign	58.44	10.40	35	252933	901	90374578
Dementia	57.81	10.40	172	252796	23689	90351790
Mouth swelling	57.60	10.40	75	252893	5587	90369892
Hyperparathyroidism secondary	56.48	10.40	44	252924	1757	90373722
Dental discomfort	56.37	10.40	28	252940	491	90374988
Lymphoedema	56.31	10.40	121	252847	13632	90361847
Coeliac disease	56.26	10.40	27	252941	44583	90330896
Polymyalgia rheumatica	55.49	10.40	69	252899	4908	90370571
Laryngitis	55.01	10.40	37	252931	50716	90324763
Living in residential institution	54.79	10.40	30	252938	648	90374831
Respiratory failure	54.51	10.40	160	252808	118258	90257221
Oxygen saturation decreased	54.13	10.40	139	252829	107344	90268135
Blood alkaline phosphatase decreased	53.23	10.40	40	252928	1513	90373966
Device failure	53.21	10.40	80	252888	6817	90368662
Cellulitis	52.96	10.40	436	252532	90901	90284578
Spinal operation	52.89	10.40	99	252869	10097	90365382
Metastasis	52.89	10.40	75	252893	6062	90369417
Respiratory arrest	52.49	10.40	14	252954	33297	90342182
Fluid retention	52.44	10.40	104	252864	87987	90287492
Dental prosthesis placement	52.38	10.40	16	252952	65	90375414
Oral infection	52.26	10.40	69	252899	5211	90370268
Product label confusion	51.62	10.40	3	252965	22847	90352632
Psychotic disorder	51.39	10.40	12	252956	31218	90344261
Parathyroidectomy	50.76	10.40	23	252945	325	90375154
Toxic epidermal necrolysis	50.63	10.40	14	252954	32514	90342965
Parathyroid disorder	50.48	10.40	30	252938	761	90374718
Gait inability	50.11	10.40	224	252744	146232	90229247
Incorrect dose administered	49.78	10.40	90	252878	78840	90296639
Onychomycosis	49.68	10.40	21	252947	37355	90338124
Hyponatraemia	49.54	10.40	198	252770	133340	90242139
Premature baby	49.27	10.40	6	252962	25071	90350408
Bone sequestrum	48.86	10.40	37	252931	1416	90374063
Bone giant cell tumour malignant	48.84	10.40	10	252958	0	90375479
Nausea	48.75	10.40	2569	250399	1107747	89267732
Dysarthria	48.74	10.40	48	252920	54434	90321045
Parathyroid tumour	48.66	10.40	18	252950	145	90375334
Ulna fracture	48.03	10.40	35	252933	1262	90374217
Hepatitis	47.97	10.40	77	252891	70662	90304817
Hepatic cirrhosis	47.64	10.40	64	252904	63189	90312290
Osteolysis	47.47	10.40	54	252914	3496	90371983
Intentional product misuse	47.37	10.40	113	252855	89491	90285988
Oedema peripheral	47.10	10.40	476	252492	257439	90118040
Red blood cell sedimentation rate abnormal	47.04	10.40	6	252962	24198	90351281
Drug level increased	47.02	10.40	10	252958	27752	90347727
Taste disorder	46.63	10.40	62	252906	61484	90313995
Trismus	46.18	10.40	62	252906	4759	90370720
Chest discomfort	45.92	10.40	214	252754	138151	90237328
Oral surgery	45.78	10.40	37	252931	1559	90373920
Ankle fracture	45.76	10.40	143	252825	20227	90355252
Wrong product administered	45.60	10.40	79	252889	7586	90367893
Frequent bowel movements	45.58	10.40	55	252913	56880	90318599
Haematochezia	45.49	10.40	80	252888	70833	90304646
Drug withdrawal syndrome	45.39	10.40	12	252956	28711	90346768
Oral discomfort	44.97	10.40	94	252874	10389	90365090
Dizziness	44.86	10.40	1277	251691	588007	89787472
Multiple organ dysfunction syndrome	44.84	10.40	76	252892	68260	90307219
Bone resorption test abnormal	44.16	10.40	10	252958	6	90375473
Breast cancer recurrent	44.13	10.40	65	252903	5438	90370041
Hot flush	44.13	10.40	301	252667	59187	90316292
Hormone receptor positive HER2 negative breast cancer	44.05	10.40	20	252948	284	90375195
Osteosclerosis	43.60	10.40	57	252911	4263	90371216
Pleural neoplasm	43.14	10.40	22	252946	409	90375070
Hypoglycaemia	42.84	10.40	81	252887	69767	90305712
Mental status changes	42.77	10.40	37	252931	44642	90330837
Oral cavity fistula	42.61	10.40	25	252943	619	90374860
Diverticulitis	42.51	10.40	243	252725	44944	90330535
Hungry bone syndrome	42	10.40	16	252952	141	90375338
Oestrogen deficiency	41.90	10.40	16	252952	142	90375337
Lichen planus	41.71	10.40	45	252923	2746	90372733
Rectal haemorrhage	41.66	10.40	107	252861	82637	90292842
Abdominal lymphadenopathy	41.29	10.40	29	252939	986	90374493
Sinus tachycardia	41.27	10.40	14	252954	28499	90346980
Bone graft	41.16	10.40	29	252939	991	90374488
Immune system disorder	40.15	10.40	97	252871	11808	90363671
Stomatitis	40.04	10.40	533	252435	274165	90101314
Hallucination	40.01	10.40	77	252891	65882	90309597
Generalised tonic-clonic seizure	39.81	10.40	24	252944	34879	90340600
Patella fracture	39.77	10.40	42	252926	2501	90372978
Eosinophilia	39.61	10.40	15	252953	28518	90346961
Refusal of treatment by patient	39.30	10.40	63	252905	5675	90369804
Hypoaesthesia oral	39.27	10.40	114	252854	15486	90359993
Rheumatoid nodule	39.19	10.40	5	252963	20161	90355318
Sedation	39.13	10.40	46	252922	48125	90327354
Infusion site reaction	38.80	10.40	4	252964	19035	90356444
Hyperparathyroidism primary	38.46	10.40	21	252947	451	90375028
Bone cancer	38.36	10.40	34	252934	1628	90373851
Device dislocation	38.28	10.40	20	252948	31462	90344017
Noninfective gingivitis	38.09	10.40	38	252930	2115	90373364
Forearm fracture	38.06	10.40	23	252945	602	90374877
Oral disorder	37.84	10.40	87	252881	10258	90365221
Metastases to peritoneum	37.62	10.40	52	252916	4103	90371376
Pustular psoriasis	37.56	10.40	4	252964	18552	90356927
Back injury	37.36	10.40	45	252923	46577	90328902
Kyphosis	36.81	10.40	43	252925	2865	90372614
Musculoskeletal disorder	36.80	10.40	139	252829	21630	90353849
Denture wearer	36.57	10.40	16	252952	207	90375272
Rhabdomyolysis	36.47	10.40	54	252914	51202	90324277
Sedation complication	36.03	10.40	3	252965	16941	90358538
Nerve compression	35.54	10.40	86	252882	10480	90364999
Pollakiuria	35.43	10.40	184	252784	32821	90342658
Disability	35.19	10.40	37	252931	40708	90334771
Osteoporosis	35.04	10.40	418	252550	96113	90279366
Alopecia	34.87	10.40	1084	251884	493987	89881492
Ulcer haemorrhage	34.64	10.40	15	252953	26306	90349173
Rash papular	34.43	10.40	130	252838	20225	90355254
Emotional distress	34.32	10.40	31	252937	36631	90338848
Loss of consciousness	34.08	10.40	240	252728	139998	90235481
Disease progression	33.87	10.40	620	252348	155995	90219484
Vitamin D increased	33.84	10.40	25	252943	921	90374558
Ear infection	33.78	10.40	92	252876	69683	90305796
Parathyroid hormone-related protein increased	33.55	10.40	8	252960	8	90375471
Drug tolerance	33.50	10.40	5	252963	17911	90357568
Female genital tract fistula	33.38	10.40	5	252963	17863	90357616
Gastrointestinal haemorrhage	33.35	10.40	134	252834	90114	90285365
Metastatic neoplasm	33.16	10.40	53	252915	4762	90370717
Caesarean section	32.92	10.40	6	252962	18571	90356908
Scab	32.56	10.40	79	252889	9642	90365837
Onychoclasis	32.51	10.40	67	252901	7332	90368147
White blood cell count increased	32.30	10.40	89	252879	67152	90308327
Intervertebral disc protrusion	32.29	10.40	156	252812	27040	90348439
Chronic sinusitis	32.24	10.40	13	252955	23789	90351690
Cytokine release syndrome	32.23	10.40	19	252949	27954	90347525
Cytomegalovirus infection	32.20	10.40	17	252951	26585	90348894
Seronegative arthritis	32.07	10.40	6	252962	18228	90357251
Neutrophil count decreased	32.06	10.40	323	252645	71209	90304270
Chemotherapy	31.87	10.40	32	252936	1795	90373684
Hepatic lesion	31.85	10.40	57	252911	5616	90369863
Vertigo	31.66	10.40	316	252652	69495	90305984
Affect lability	31.65	10.40	6	252962	18057	90357422
Heavy menstrual bleeding	31.65	10.40	9	252959	20521	90354958
Proctitis	31.64	10.40	3	252965	15256	90360223
Nail disorder	31.61	10.40	74	252894	58993	90316486
Status epilepticus	31.56	10.40	7	252961	18867	90356612
Hyperhidrosis	31.33	10.40	237	252731	136068	90239411
Streptococcal sepsis	31.18	10.40	44	252924	3540	90371939
Cataract operation	30.92	10.40	59	252909	6104	90369375
Metastases to adrenals	30.90	10.40	24	252944	954	90374525
Hemiparesis	30.88	10.40	26	252942	31793	90343686
Schizophrenia	30.74	10.40	3	252965	14911	90360568
Rotator cuff syndrome	30.60	10.40	106	252862	15813	90359666
Rash macular	30.58	10.40	166	252802	30114	90345365
Intercepted medication error	30.51	10.40	23	252945	874	90374605
Hyperkalaemia	30.46	10.40	87	252881	64877	90310602
Right ventricular failure	30.39	10.40	8	252960	19197	90356282
Cognitive disorder	30.35	10.40	96	252872	69311	90306168
Hip surgery	30.03	10.40	47	252921	4148	90371331
Visual impairment	30.02	10.40	231	252737	132134	90243345
Muscle tightness	29.87	10.40	94	252874	13345	90362134
Blood 25-hydroxycholecalciferol decreased	29.80	10.40	11	252957	88	90375391
Upper respiratory tract infection	29.54	10.40	223	252745	128095	90247384
Extrapyramidal disorder	29.47	10.40	5	252963	16298	90359181
Finger deformity	29.41	10.40	29	252939	32868	90342611
Metastases to bladder	29.23	10.40	14	252954	226	90375253
Obstructive airways disorder	29.21	10.40	18	252950	25851	90349628
Poisoning	29.03	10.40	4	252964	15213	90360266
Periprosthetic fracture	28.97	10.40	19	252949	576	90374903
Muscle atrophy	28.92	10.40	69	252899	8332	90367147
Flushing	28.69	10.40	138	252830	88353	90287126
Cancer pain	28.68	10.40	45	252923	3980	90371499
Mydriasis	28.51	10.40	4	252964	15008	90360471
Coordination abnormal	28.38	10.40	12	252956	21344	90354135
Tachypnoea	28.28	10.40	12	252956	21297	90354182
Clavicle fracture	28.21	10.40	44	252924	3872	90371607
Aggression	28.16	10.40	20	252948	26648	90348831
Respiratory disorder	28.09	10.40	90	252878	64726	90310753
Gingival erythema	28.08	10.40	24	252944	1094	90374385
Infusion site pain	28.03	10.40	10	252958	19728	90355751
Vertebroplasty	28.02	10.40	16	252952	376	90375103
Lung neoplasm malignant	27.94	10.40	138	252830	24135	90351344
Insomnia	27.84	10.40	713	252255	332761	90042718
Blood pressure decreased	27.80	10.40	111	252857	74784	90300695
Peri-implantitis	27.54	10.40	10	252958	76	90375403
Pancreatitis	27.53	10.40	101	252867	69725	90305754
Stevens-Johnson syndrome	27.31	10.40	25	252943	29351	90346128
Adrenal insufficiency	27.18	10.40	26	252942	29895	90345584
Dysstasia	27.12	10.40	140	252828	24912	90350567
Underdose	27.08	10.40	70	252898	53947	90321532
Gait disturbance	27.07	10.40	934	252034	259562	90115917
Food allergy	27.04	10.40	19	252949	25459	90350020
Gingival cyst	26.88	10.40	6	252962	3	90375476
Dental prosthesis user	26.88	10.40	9	252959	52	90375427
Drug reaction with eosinophilia and systemic symptoms	26.74	10.40	49	252919	42709	90332770
Tooth discolouration	26.65	10.40	24	252944	1174	90374305
Hallucination, auditory	26.56	10.40	6	252962	15969	90359510
Joint destruction	26.55	10.40	3	252965	13284	90362195
Abscess oral	26.45	10.40	27	252941	1545	90373934
Rehabilitation therapy	26.35	10.40	30	252938	1944	90373535
Monocytosis	26.33	10.40	22	252946	972	90374507
Cardiogenic shock	26.30	10.40	18	252950	24450	90351029
Metaphyseal corner fracture	26.29	10.40	8	252960	32	90375447
Gingival operation	26.20	10.40	12	252956	174	90375305
Limb discomfort	26.13	10.40	189	252779	37871	90337608
Varicose vein	26.12	10.40	61	252907	7266	90368213
Dysuria	26.10	10.40	194	252774	39207	90336272
Giant cell arteritis	26.08	10.40	37	252931	2992	90372487
Bone cancer metastatic	26.02	10.40	13	252955	231	90375248
Vascular device infection	26.02	10.40	83	252885	11869	90363610
Nasal congestion	25.94	10.40	132	252836	83282	90292197
Pulmonary arterial hypertension	25.91	10.40	21	252947	26166	90349313
Pain of skin	25.80	10.40	101	252867	15981	90359498
Vaginal discharge	25.76	10.40	11	252957	19453	90356026
Septic shock	25.71	10.40	134	252834	84026	90291453
Staphylococcal infection	25.67	10.40	61	252907	48378	90327101
Nephrolithiasis	25.66	10.40	229	252739	48856	90326623
Paranoia	25.58	10.40	3	252965	12905	90362574
Ventricular tachycardia	25.48	10.40	19	252949	24689	90350790
Gingival ulceration	25.39	10.40	22	252946	1022	90374457
Neoplasm	25.31	10.40	68	252900	8835	90366644
Transplant rejection	25.19	10.40	3	252965	12755	90362724
Hypercalciuria	25.19	10.40	15	252953	382	90375097
Fibroblast growth factor 23 increased	25.16	10.40	6	252962	6	90375473
Nail bed inflammation	25.11	10.40	28	252940	1773	90373706
Triple negative breast cancer	24.95	10.40	15	252953	389	90375090
Mastectomy	24.86	10.40	30	252938	2069	90373410
Calcinosis	24.81	10.40	34	252934	2661	90372818
Hypervolaemia	24.81	10.40	33	252935	32724	90342755
Weight bearing difficulty	24.75	10.40	35	252933	2821	90372658
Circulatory collapse	24.60	10.40	20	252948	24884	90350595
Disease recurrence	24.58	10.40	42	252926	37611	90337868
Syncope	24.55	10.40	244	252724	132419	90243060
Hair disorder	24.32	10.40	23	252945	1198	90374281
Blood pressure abnormal	24.28	10.40	114	252854	19531	90355948
Tremor	24.24	10.40	292	252676	152881	90222598
Metastases to meninges	24.21	10.40	40	252928	3695	90371784
Injection site erythema	24.21	10.40	168	252800	98334	90277145
Product substitution issue	24.12	10.40	10	252958	17998	90357481
Breast disorder	24.12	10.40	34	252934	2733	90372746
Pleural effusion	24.09	10.40	443	252525	111548	90263931
Carbohydrate antigen 27.29 increased	24.06	10.40	10	252958	113	90375366
Bone swelling	24.04	10.40	27	252941	1724	90373755
Irritability	24.01	10.40	39	252929	35623	90339856
Acute myeloid leukaemia	23.81	10.40	14	252954	20626	90354853
Foot deformity	23.70	10.40	86	252882	59565	90315914
Paronychia	23.62	10.40	62	252906	7944	90367535
Invasive ductal breast carcinoma	23.53	10.40	61	252907	7757	90367722
Cataract	23.51	10.40	306	252662	71786	90303693
Memory impairment	23.46	10.40	398	252570	196846	90178633
Malpositioned teeth	23.41	10.40	7	252961	26	90375453
Nightmare	23.33	10.40	16	252952	21709	90353770
Abortion induced	22.97	10.40	3	252965	11885	90363594
Dysgeusia	22.92	10.40	236	252732	52324	90323155
Agranulocytosis	22.89	10.40	39	252929	34963	90340516
Nasal mucosal disorder	22.75	10.40	27	252941	1830	90373649
Dyskinesia	22.73	10.40	42	252926	36492	90338987
Cyanosis	22.72	10.40	13	252955	19442	90356037
Coagulopathy	22.64	10.40	19	252949	23270	90352209
Leukopenia	22.58	10.40	401	252567	100309	90275170
Oral mucosal erythema	22.45	10.40	26	252942	1716	90373763
Cervical vertebral fracture	22.34	10.40	36	252932	3257	90372222
Bone metabolism biochemical marker increased	22.25	10.40	7	252961	32	90375447
Neuroglycopenia	22.21	10.40	21	252947	1094	90374385
Neck pain	22.19	10.40	444	252524	113519	90261960
Osteomalacia	22.05	10.40	19	252949	876	90374603
Blood cholesterol decreased	21.90	10.40	27	252941	1904	90373575
Fibula fracture	21.80	10.40	41	252927	4196	90371283
Spinal disorder	21.79	10.40	77	252891	11602	90363877
Gingival injury	21.74	10.40	7	252961	35	90375444
Acetabulum fracture	21.74	10.40	14	252954	411	90375068
Thyroid operation	21.74	10.40	11	252957	201	90375278
Drug resistance	21.74	10.40	32	252936	30417	90345062
Skin disorder	21.69	10.40	176	252792	36530	90338949
Hepatic cyst	21.60	10.40	53	252915	6515	90368964
Breath sounds abnormal	21.51	10.40	8	252960	15378	90360101
Heart rate decreased	21.35	10.40	77	252891	53428	90322051
Metastases to bone marrow	21.34	10.40	16	252952	603	90374876
Bone infarction	21.30	10.40	14	252954	426	90375053
Osteochondrosis	21.27	10.40	26	252942	1817	90373662
Product prescribing error	21.21	10.40	32	252936	30113	90345366
Angioedema	21.13	10.40	101	252867	64775	90310704
Akathisia	21.13	10.40	3	252965	11156	90364323
Photophobia	21.11	10.40	17	252951	21252	90354227
Blood creatinine abnormal	21.11	10.40	40	252928	4117	90371362
Accidental overdose	20.89	10.40	29	252939	28244	90347235
Bone marrow oedema	20.84	10.40	23	252945	1440	90374039
Tubulointerstitial nephritis	20.80	10.40	24	252944	25319	90350160
Posterior reversible encephalopathy syndrome	20.78	10.40	19	252949	22320	90353159
Peripheral circulatory failure	20.78	10.40	24	252944	1580	90373899
Erysipelas	20.75	10.40	64	252904	8988	90366491
Hyperlipidaemia	20.75	10.40	122	252846	22794	90352685
Thyroid mass	20.66	10.40	46	252922	5309	90370170
Acute respiratory distress syndrome	20.62	10.40	30	252938	28656	90346823
Burning sensation	20.55	10.40	269	252699	63183	90312296
Tumour marker abnormal	20.52	10.40	13	252955	371	90375108
Dental paraesthesia	20.50	10.40	5	252963	6	90375473
Nasal polyps	20.43	10.40	3	252965	10877	90364602
Bronchitis	20.39	10.40	302	252666	152625	90222854
VIth nerve paresis	20.38	10.40	8	252960	77	90375402
Vertebral wedging	20.34	10.40	6	252962	21	90375458
Amenorrhoea	20.31	10.40	4	252964	11718	90363761
Respiratory depression	20.30	10.40	9	252959	15566	90359913
Vertebral lesion	20.27	10.40	17	252951	755	90374724
Activated PI3 kinase delta syndrome	20.11	10.40	8	252960	80	90375399
CYP3A4 polymorphism	20.11	10.40	8	252960	80	90375399
Blood magnesium decreased	20.08	10.40	92	252876	15601	90359878
Oral neoplasm benign	20.06	10.40	5	252963	7	90375472
Personality disorder	20.05	10.40	5	252963	12439	90363040
Haematemesis	19.91	10.40	40	252928	33686	90341793
Second primary malignancy	19.86	10.40	69	252899	10309	90365170
Bone density increased	19.81	10.40	18	252950	891	90374588
Vaccination site reaction	19.75	10.40	11	252957	246	90375233
Bone deformity	19.74	10.40	15	252953	577	90374902
Respiratory rate increased	19.70	10.40	10	252958	15991	90359488
Labelled drug-drug interaction medication error	19.69	10.40	8	252960	14574	90360905
Hypomagnesaemia	19.62	10.40	168	252800	35420	90340059
Orthostatic hypotension	19.62	10.40	56	252912	41771	90333708
Bacteraemia	19.54	10.40	20	252948	22280	90353199
Serum procollagen type I N-terminal propeptide decreased	19.54	10.40	4	252964	0	90375479
Impaired healing	19.46	10.40	501	252467	233698	90141781
Oroantral fistula	19.41	10.40	10	252958	190	90375289
Panniculitis	19.41	10.40	8	252960	14450	90361029
Osteocalcin decreased	19.41	10.40	7	252961	52	90375427
Root canal infection	19.37	10.40	13	252955	410	90375069
Hypercalcaemia of malignancy	19.32	10.40	11	252957	257	90375222
Complication of device insertion	19.31	10.40	3	252965	10433	90365046
Radiation fibrosis - lung	19.30	10.40	7	252961	53	90375426
Blood 1,25-dihydroxycholecalciferol increased	19.30	10.40	7	252961	53	90375426
Joint dislocation	19.25	10.40	62	252906	44520	90330959
Macule	19.24	10.40	30	252938	2639	90372840
Mouth ulceration	19.13	10.40	183	252785	39791	90335688
Pneumonia aspiration	19.06	10.40	55	252913	40885	90334594
Hyperthermia	19.06	10.40	3	252965	10332	90365147
Osteosarcoma	18.86	10.40	9	252959	144	90375335
Breast pain	18.85	10.40	68	252900	10350	90365129
Withdrawal syndrome	18.85	10.40	21	252947	22503	90352976
Eastern Cooperative Oncology Group performance status worsened	18.67	10.40	25	252943	1914	90373565
Fistula	18.65	10.40	75	252893	12014	90363465
Anuria	18.64	10.40	9	252959	14809	90360670
Injection site pruritus	18.61	10.40	82	252886	53752	90321727
Ventricular fibrillation	18.49	10.40	8	252960	14036	90361443
Orthodontic procedure	18.34	10.40	5	252963	12	90375467
General symptom	18.31	10.40	9	252959	14659	90360820
Cerebrovascular accident	18.30	10.40	463	252505	123070	90252409
White blood cell disorder	18.22	10.40	31	252937	2933	90372546
Palliative care	18.21	10.40	17	252951	871	90374608
Myoclonus	18.19	10.40	16	252952	19152	90356327
Adjusted calcium decreased	18.18	10.40	10	252958	218	90375261
Polyneuropathy	18.18	10.40	104	252864	19237	90356242
Illness	18.14	10.40	144	252824	81825	90293654
Delusion	18.04	10.40	8	252960	13832	90361647
Pancytopenia	18.00	10.40	232	252736	120031	90255448
Drug dependence	17.99	10.40	34	252934	29293	90346186
Abnormal behaviour	17.96	10.40	22	252946	22606	90352873
Heart rate increased	17.95	10.40	215	252753	112687	90262792
Invasive lobular breast carcinoma	17.91	10.40	18	252950	1011	90374468
Gastroenteritis radiation	17.89	10.40	14	252954	563	90374916
Rales	17.89	10.40	11	252957	15816	90359663
Malaise	17.81	10.40	1401	251567	584585	89790894
Cholecystitis chronic	17.79	10.40	3	252965	9823	90365656
Pseudomonal sepsis	17.79	10.40	38	252930	4264	90371215
Metastases to gastrointestinal tract	17.79	10.40	8	252960	111	90375368
Mucosal inflammation	17.71	10.40	242	252726	57383	90318096
Creatinine renal clearance decreased	17.67	10.40	16	252952	18883	90356596
Tumour pain	17.67	10.40	24	252944	1863	90373616
Respiratory distress	17.64	10.40	53	252915	38893	90336586
Sternal fracture	17.49	10.40	30	252938	2857	90372622
Aphasia	17.49	10.40	61	252907	42751	90332728
Gingival discolouration	17.42	10.40	11	252957	312	90375167
Body temperature increased	17.41	10.40	65	252903	44645	90330834
Immunodeficiency	17.39	10.40	62	252906	43172	90332307
Pancreatitis acute	17.37	10.40	40	252928	32075	90343404
Hypothermia	17.36	10.40	11	252957	15564	90359915
Inguinal hernia repair	17.26	10.40	7	252961	74	90375405
Liver function test abnormal	17.24	10.40	78	252890	50767	90324712
Acidosis	17.18	10.40	7	252961	12729	90362750
Blood pressure increased	17.16	10.40	419	252549	196798	90178681
Pulmonary hypertension	17.09	10.40	61	252907	42462	90333017
Allergy to plants	17.07	10.40	16	252952	824	90374655
Neuropathy peripheral	17.06	10.40	502	252466	136468	90239011
Granuloma annulare	17.01	10.40	16	252952	828	90374651
Hypoaesthesia teeth	16.95	10.40	6	252962	42	90375437
Cardiac failure congestive	16.84	10.40	185	252783	98509	90276970
Renal impairment	16.78	10.40	399	252569	105022	90270457
Tartrate-resistant acid phosphatase increased	16.78	10.40	4	252964	4	90375475
Hypercalcaemic nephropathy	16.78	10.40	4	252964	4	90375475
Medial tibial stress syndrome	16.76	10.40	8	252960	128	90375351
Pelvic pain	16.75	10.40	86	252882	15271	90360208
Ejection fraction decreased	16.68	10.40	128	252840	26125	90349354
Bronchospasm	16.58	10.40	20	252948	20689	90354790
Adnexa uteri mass	16.50	10.40	14	252954	632	90374847
Enchondromatosis	16.49	10.40	8	252960	133	90375346
Bone scan abnormal	16.46	10.40	12	252956	433	90375046
Haematoma	16.38	10.40	55	252913	38993	90336486
Malocclusion	16.38	10.40	8	252960	135	90375344
Aspartate aminotransferase increased	16.37	10.40	196	252772	102741	90272738
Alanine aminotransferase increased	16.37	10.40	232	252736	118106	90257373
Intermenstrual bleeding	16.30	10.40	3	252965	9220	90366259
Metastases to the mediastinum	16.29	10.40	14	252954	643	90374836
Sinus bradycardia	16.27	10.40	14	252954	16938	90358541
Macular degeneration	16.26	10.40	53	252915	37917	90337562
Aspergillus infection	16.22	10.40	5	252963	10818	90364661
Tooth deposit	16.21	10.40	10	252958	272	90375207
Disturbance in attention	16.14	10.40	72	252896	47037	90328442
Pulmonary tumour thrombotic microangiopathy	16.11	10.40	7	252961	89	90375390
Device malfunction	16.02	10.40	21	252947	20956	90354523
Sputum discoloured	16.00	10.40	20	252948	20371	90355108
Metastases to spinal cord	15.92	10.40	10	252958	281	90375198
Angina pectoris	15.86	10.40	56	252912	39104	90336375
Sinus congestion	15.79	10.40	33	252935	27391	90348088
Spondylolisthesis	15.72	10.40	35	252933	4040	90371439
Dermo-hypodermitis	15.69	10.40	15	252953	792	90374687
Hepatic cancer	15.64	10.40	39	252929	4842	90370637
Dental cyst	15.64	10.40	6	252962	54	90375425
Scapula fracture	15.60	10.40	12	252956	470	90375009
Carbohydrate antigen 15-3	15.57	10.40	7	252961	97	90375382
Papillary thyroid cancer	15.53	10.40	27	252941	2600	90372879
Drug level decreased	15.50	10.40	4	252964	9726	90365753
Product communication issue	15.45	10.40	20	252948	1481	90373998
Oral pustule	15.45	10.40	6	252962	56	90375423
Shock	15.44	10.40	36	252932	28742	90346737
Tumour invasion	15.40	10.40	10	252958	298	90375181
Ear disorder	15.38	10.40	38	252930	4692	90370787
Gas gangrene	15.30	10.40	8	252960	157	90375322
Adjustment disorder	15.29	10.40	4	252964	9638	90365841
Renal tubular necrosis	15.26	10.40	11	252957	14544	90360935
Surgery	15.26	10.40	192	252776	44695	90330784
Pleural disorder	15.25	10.40	14	252954	702	90374777
Breast cancer stage I	15.25	10.40	4	252964	9620	90365859
Micturition urgency	15.23	10.40	67	252901	11166	90364313
Encephalitis	15.21	10.40	6	252962	11128	90364351
Facial pain	15.21	10.40	75	252893	13107	90362372
Bruxism	15.20	10.40	36	252932	4327	90371152
Device fastener issue	15.19	10.40	7	252961	103	90375376
Malabsorption	15.17	10.40	40	252928	5138	90370341
Lumbar spinal stenosis	15.16	10.40	42	252926	5555	90369924
Epstein-Barr virus infection	15.11	10.40	5	252963	10339	90365140
Brachiocephalic vein thrombosis	15.07	10.40	7	252961	105	90375374
Dental plaque	15.07	10.40	7	252961	105	90375374
Skin necrosis	15.07	10.40	15	252953	16926	90358553
Osteosarcoma recurrent	15.06	10.40	5	252963	28	90375451
Nail discolouration	15.01	10.40	30	252938	3212	90372267
Eye injury	14.95	10.40	6	252962	11014	90364465
Haematotoxicity	14.95	10.40	72	252896	12463	90363016
Retinal operation	14.92	10.40	5	252963	29	90375450
Blood creatine phosphokinase increased	14.91	10.40	47	252921	33976	90341503
Blood cholesterol abnormal	14.91	10.40	28	252940	2862	90372617
Ataxia	14.90	10.40	17	252951	18025	90357454
Osteoarthritis	14.88	10.40	424	252544	195306	90180173
Chronic leukaemia	14.85	10.40	4	252964	9	90375470
Carcinoid tumour pulmonary	14.80	10.40	12	252956	508	90374971
Bone neoplasm	14.80	10.40	15	252953	851	90374628
Mucosal pain	14.77	10.40	5	252963	30	90375449
Gingival atrophy	14.77	10.40	5	252963	30	90375449
Disorientation	14.76	10.40	68	252900	44046	90331433
Muscle disorder	14.73	10.40	41	252927	5438	90370041
Acute phase reaction	14.71	10.40	10	252958	322	90375157
Dysphagia	14.67	10.40	414	252554	111864	90263615
Sinus perforation	14.65	10.40	3	252965	0	90375479
C-telopeptide decreased	14.65	10.40	3	252965	0	90375479
Masticatory pain	14.65	10.40	3	252965	0	90375479
C-telopeptide	14.65	10.40	3	252965	0	90375479
Adenoid cystic carcinoma	14.64	10.40	5	252963	31	90375448
Parathyroid gland operation	14.64	10.40	5	252963	31	90375448
Metastases to uterus	14.61	10.40	7	252961	113	90375366
Plantar fasciitis	14.60	10.40	35	252933	4239	90371240
Hypoacusis	14.59	10.40	130	252838	27720	90347759
Bone fistula	14.58	10.40	6	252962	66	90375413
Pancreatogenous diabetes	14.55	10.40	4	252964	10	90375469
Blood phosphorus abnormal	14.52	10.40	8	252960	175	90375304
Onychalgia	14.50	10.40	17	252951	1137	90374342
Acute coronary syndrome	14.49	10.40	6	252962	10807	90364672
Gangrene	14.48	10.40	9	252959	12867	90362612
Acute respiratory failure	14.46	10.40	66	252902	42852	90332627
Intervertebral disc degeneration	14.39	10.40	90	252878	17184	90358295
Lip exfoliation	14.39	10.40	14	252954	756	90374723
Hypocalcaemic seizure	14.37	10.40	5	252963	33	90375446
Diabetic ketoacidosis	14.36	10.40	29	252939	24378	90351101
Psychomotor hyperactivity	14.35	10.40	9	252959	12804	90362675
Bronchopulmonary aspergillosis	14.22	10.40	7	252961	11391	90364088
Pre-existing condition improved	14.17	10.40	4	252964	9165	90366314
Leukocytosis	14.16	10.40	42	252926	30948	90344531
Tachyphylaxis	14.16	10.40	10	252958	343	90375136
Panic attack	14.13	10.40	33	252935	26332	90349147
Cardiac murmur	14.12	10.40	18	252950	18176	90357303
Skin irritation	14.03	10.40	75	252893	13528	90361951
Virilism foetal	14.03	10.40	4	252964	12	90375467
Haemoptysis	13.93	10.40	47	252921	33273	90342206
Bone marrow failure	13.78	10.40	45	252923	32176	90343303
Progressive multifocal leukoencephalopathy	13.76	10.40	14	252954	15641	90359838
Urine calcium increased	13.76	10.40	6	252962	77	90375402
Respiratory syncytial virus infection	13.75	10.40	6	252962	10474	90365005
Pallor	13.74	10.40	49	252919	34116	90341363
Gastrointestinal bacterial infection	13.72	10.40	16	252952	1064	90374415
Ankylosing spondylitis	13.67	10.40	10	252958	13123	90362356
Graft versus host disease	13.66	10.40	3	252965	8141	90367338
Bronchiectasis	13.60	10.40	26	252942	22304	90353175
Hemiplegia	13.59	10.40	15	252953	16145	90359334
Degenerative bone disease	13.54	10.40	9	252959	279	90375200
Lower gastrointestinal haemorrhage	13.52	10.40	4	252964	8888	90366591
Spinal cord compression	13.45	10.40	37	252931	4874	90370605
Open fracture	13.42	10.40	11	252957	473	90375006
Infusion site extravasation	13.41	10.40	6	252962	10322	90365157
Lymphoma	13.38	10.40	74	252894	13517	90361962
Ear pain	13.38	10.40	231	252737	57471	90318008
Immune-mediated lung disease	13.37	10.40	21	252947	1859	90373620
Blood 1,25-dihydroxycholecalciferol decreased	13.35	10.40	4	252964	15	90375464
Bone marrow infiltration	13.33	10.40	14	252954	828	90374651
Pneumocystis jirovecii pneumonia	13.31	10.40	25	252943	21591	90353888
Gingival bleeding	13.27	10.40	79	252889	14824	90360655
Nail growth abnormal	13.27	10.40	12	252956	590	90374889
Tardive dyskinesia	13.21	10.40	7	252961	10923	90364556
Shock haemorrhagic	13.17	10.40	9	252959	12236	90363243
Knee operation	13.17	10.40	46	252922	6890	90368589
Metastases to neck	13.16	10.40	6	252962	86	90375393
Periprosthetic metallosis	13.14	10.40	4	252964	16	90375463
Jaw cyst	13.14	10.40	7	252961	143	90375336
Hemianopia	13.10	10.40	22	252946	2060	90373419
Toxic encephalopathy	13.07	10.40	4	252964	8695	90366784
Skin mass	13.02	10.40	48	252920	7382	90368097
Metastases to vagina	12.95	10.40	4	252964	17	90375462
Conjunctival haemorrhage	12.94	10.40	32	252936	3952	90371527
Mean cell volume increased	12.94	10.40	37	252931	4984	90370495
Periumbilical abscess	12.92	10.40	8	252960	219	90375260
Sensory loss	12.90	10.40	19	252949	18056	90357423
Skin sensitisation	12.83	10.40	15	252953	1000	90374479
Altered state of consciousness	12.83	10.40	45	252923	31487	90343992
Carcinoembryonic antigen	12.80	10.40	6	252962	92	90375387
Ilium fracture	12.79	10.40	7	252961	151	90375328
Catheter site injury	12.79	10.40	9	252959	307	90375172
Oligodipsia	12.75	10.40	5	252963	48	90375431
Purulence	12.72	10.40	19	252949	1610	90373869
Aplastic anaemia	12.68	10.40	11	252957	13258	90362221
High turnover osteopathy	12.66	10.40	5	252963	49	90375430
Respiratory tract congestion	12.63	10.40	37	252931	27373	90348106
Urethritis noninfective	12.59	10.40	4	252964	19	90375460
Injected limb mobility decreased	12.59	10.40	4	252964	19	90375460
Extradural neoplasm	12.58	10.40	3	252965	3	90375476
Phosphaturic mesenchymal tumour	12.58	10.40	3	252965	3	90375476
Joint deposit	12.58	10.40	3	252965	3	90375476
Oliguria	12.55	10.40	7	252961	10617	90364862
Chondropathy	12.54	10.40	24	252944	2488	90372991
Injection site haemorrhage	12.50	10.40	39	252929	28279	90347200
Ovarian disorder	12.47	10.40	14	252954	893	90374586
Colitis	12.37	10.40	130	252838	69812	90305667
Bladder cancer	12.37	10.40	40	252928	5761	90369718
Polyglandular autoimmune syndrome type II	12.31	10.40	5	252963	53	90375426
Haemophagocytic lymphohistiocytosis	12.30	10.40	15	252953	15444	90360035
Lip and/or oral cavity cancer	12.29	10.40	14	252954	908	90374571
Sarcoma	12.27	10.40	12	252956	652	90374827
Hypovolaemia	12.26	10.40	10	252958	12421	90363058
Oral lichen planus	12.26	10.40	13	252955	778	90374701
Mood altered	12.26	10.40	18	252950	17126	90358353
Extraskeletal ossification	12.16	10.40	7	252961	167	90375312
Metastases to chest wall	12.16	10.40	12	252956	659	90374820
Neuralgia	12.14	10.40	138	252830	31362	90344117
Leukaemia	12.11	10.40	36	252932	4956	90370523
Basal cell carcinoma	12.07	10.40	50	252918	33339	90342140
Blood glucose increased	12.04	10.40	190	252778	95056	90280423
Weight fluctuation	12.02	10.40	23	252945	19726	90355753
Blood glucose decreased	12.02	10.40	30	252938	23399	90352080
Atrial septal defect	11.99	10.40	4	252964	8230	90367249
Paraganglion neoplasm	11.96	10.40	4	252964	23	90375456
Dental alveolar anomaly	11.84	10.40	5	252963	59	90375420
Autoimmune lung disease	11.79	10.40	6	252962	111	90375368
Demyelination	11.77	10.40	4	252964	8136	90367343
Bile duct stenosis	11.76	10.40	19	252949	1723	90373756
Deafness	11.75	10.40	105	252863	22409	90353070
Intervertebral disc calcification	11.72	10.40	3	252965	5	90375474
Exposure to SARS-CoV-2	11.72	10.40	23	252945	2429	90373050
Periarthritis	11.62	10.40	26	252942	3011	90372468
Oral mucosal discolouration	11.60	10.40	9	252959	357	90375122
Oophorectomy bilateral	11.56	10.40	6	252962	116	90375363
Cardiac disorder	11.55	10.40	223	252745	56649	90318830
Oral mucosal blistering	11.53	10.40	44	252924	6880	90368599
Tumour flare	11.44	10.40	11	252957	585	90374894
Varicophlebitis	11.42	10.40	4	252964	27	90375452
Naevus haemorrhage	11.42	10.40	6	252962	119	90375360
Ulcer	11.42	10.40	50	252918	32832	90342647
Spinal laminectomy	11.41	10.40	13	252955	843	90374636
Exposure to toxic agent	11.38	10.40	4	252964	7963	90367516
N-telopeptide urine decreased	11.37	10.40	3	252965	6	90375473
Oophorectomy	11.36	10.40	12	252956	715	90374764
Tumour necrosis	11.36	10.40	14	252954	987	90374492
Nail bed tenderness	11.35	10.40	9	252959	369	90375110
Pancreatic toxicity	11.34	10.40	5	252963	66	90375413
Tumour marker decreased	11.34	10.40	5	252963	66	90375413
Callus formation delayed	11.30	10.40	4	252964	28	90375451
Cholelithiasis	11.27	10.40	93	252875	52413	90323066
Gastroenteritis viral	11.26	10.40	45	252923	30310	90345169
Acute generalised exanthematous pustulosis	11.22	10.40	13	252955	13690	90361789
Palpitations	11.22	10.40	293	252675	136435	90239044
Ludwig angina	11.21	10.40	5	252963	68	90375411
Therapeutic response shortened	11.20	10.40	30	252938	22849	90352630
Stress	11.10	10.40	160	252808	81235	90294244
Wisdom teeth removal	11.10	10.40	12	252956	734	90374745
Hepatitis cholestatic	11.08	10.40	5	252963	8556	90366923
Claudication of jaw muscles	11.08	10.40	5	252963	70	90375409
Calcium deficiency	11.06	10.40	16	252952	1317	90374162
Erythroblast count increased	11.06	10.40	3	252965	7	90375472
Hypoaesthesia	11.01	10.40	742	252226	313468	90062011
Hydrothorax	11.01	10.40	14	252954	1019	90374460
Affective disorder	10.98	10.40	4	252964	7789	90367690
Lymphangiosis carcinomatosa	10.97	10.40	18	252950	1654	90373825
Device loosening	10.96	10.40	13	252955	880	90374599
Escherichia urinary tract infection	10.90	10.40	71	252897	13744	90361735
Carbohydrate antigen 19-9 increased	10.89	10.40	8	252960	292	90375187
Hypermetabolism	10.87	10.40	8	252960	293	90375186
Complement factor C4 decreased	10.82	10.40	8	252960	295	90375184
Vascular fragility	10.80	10.40	7	252961	208	90375271
Lichen sclerosus	10.79	10.40	16	252952	1347	90374132
Deafness unilateral	10.77	10.40	27	252941	3364	90372115
Apathy	10.74	10.40	9	252959	11031	90364448
SAPHO syndrome	10.74	10.40	6	252962	135	90375344
Bone operation	10.68	10.40	8	252960	301	90375178
Endometrial cancer metastatic	10.66	10.40	6	252962	137	90375342
Vascular operation	10.66	10.40	6	252962	137	90375342
Atrophic vulvovaginitis	10.64	10.40	19	252949	1868	90373611
Squamous cell carcinoma	10.63	10.40	56	252912	10045	90365434
Spinal stenosis	10.54	10.40	84	252884	17340	90358139
Adjusted calcium increased	10.53	10.40	4	252964	35	90375444
Complement factor C3 decreased	10.52	10.40	8	252960	308	90375171
Maxillofacial operation	10.52	10.40	3	252965	9	90375470
Atelectasis	10.50	10.40	34	252934	24375	90351104
Paraesthesia	10.48	10.40	823	252145	249503	90125976
Rosacea	10.44	10.40	38	252930	5809	90369670
Dry throat	10.43	10.40	47	252921	7913	90367566
Avulsion fracture	10.43	10.40	8	252960	312	90375167
Reflux gastritis	10.43	10.40	16	252952	1388	90374091

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Osteonecrosis of jaw	8280.13	13.49	2303	51411	16746	42550875
Off label use	2807.34	13.49	3685	50029	634650	41932971
Hypocalcaemia	2296.48	13.49	994	52720	29179	42538442
Death	1735.41	13.49	2509	51205	468676	42098945
Terminal state	547.17	13.49	207	53507	4216	42563405
Prostatic specific antigen increased	475.81	13.49	285	53429	16640	42550981
Metastases to bone	473.34	13.49	271	53443	14538	42553083
Malignant neoplasm progression	364.08	13.49	557	53157	107843	42459778
Tooth disorder	329.60	13.49	199	53515	11780	42555841
Tooth extraction	306.56	13.49	146	53568	5334	42562287
Bone pain	275.11	13.49	233	53481	23559	42544062
Atypical femur fracture	268.53	13.49	67	53647	291	42567330
Investigation	246.07	13.49	77	53637	858	42566763
Blood parathyroid hormone increased	244.88	13.49	92	53622	1835	42565786
Pain in jaw	243.40	13.49	177	53537	14325	42553296
Prostate cancer metastatic	224.39	13.49	126	53588	6503	42561118
Blood calcium decreased	222.30	13.49	151	53563	10957	42556664
Hypophosphataemia	219.62	13.49	194	53520	20751	42546870
Hypercalcaemia	202.91	13.49	174	53540	17884	42549737
Exposed bone in jaw	191.56	13.49	73	53641	1516	42566105
Hospitalisation	179.75	13.49	330	53384	74000	42493621
Drug ineffective	168.56	13.49	339	53375	629858	41937763
Toxicity to various agents	153.39	13.49	49	53665	229087	42338534
Jaw disorder	147.98	13.49	66	53648	2067	42565554
Osteomyelitis	132.56	13.49	138	53576	18085	42549536
Metastases to lung	132.25	13.49	112	53602	11312	42556309
Prostate cancer	129.73	13.49	215	53499	44428	42523193
Osteitis	122.31	13.49	54	53660	1650	42565971
Metastases to lymph nodes	118.72	13.49	81	53633	5917	42561704
Toothache	114.77	13.49	87	53627	7496	42560125
Pathological fracture	113.20	13.49	75	53639	5218	42562403
Delusion of grandeur	111.07	13.49	53	53661	1943	42565678
Occupational exposure to product	106.74	13.49	34	53680	403	42567218
Condition aggravated	106.60	13.49	103	53611	260651	42306970
Drug interaction	106.24	13.49	108	53606	266891	42300730
Completed suicide	104.04	13.49	4	53710	96461	42471160
Spinal fracture	100.07	13.49	87	53627	9103	42558518
Hormone-refractory prostate cancer	99.42	13.49	40	53674	964	42566657
Bone density abnormal	96.66	13.49	25	53689	129	42567492
Rhinalgia	93.67	13.49	46	53668	1798	42565823
Dental care	91.02	13.49	29	53685	344	42567277
Hot flush	91.02	13.49	126	53588	22225	42545396
Lymphocyte count abnormal	89.08	13.49	47	53667	2140	42565481
Metastases to liver	85.15	13.49	104	53610	16222	42551399
Hypotension	84.64	13.49	121	53593	257510	42310111
Tooth fracture	79.26	13.49	55	53659	4129	42563492
Back pain	79.09	13.49	371	53343	141405	42426216
Abscess jaw	75.11	13.49	30	53684	709	42566912
Osteonecrosis	74.66	13.49	96	53618	15769	42551852
Impaired healing	73.77	13.49	99	53615	16954	42550667
Intercepted product administration error	72.35	13.49	27	53687	528	42567093
Cardiac arrest	70.22	13.49	25	53689	109295	42458326
Cancer pain	70.19	13.49	48	53666	3519	42564102
Femur fracture	69.01	13.49	73	53641	9739	42557882
Affective disorder	66.05	13.49	57	53657	5903	42561718
Metastasis	62.55	13.49	50	53664	4655	42562966
Blood calcium abnormal	61.26	13.49	26	53688	720	42566901
Fatigue	59.89	13.49	823	52891	434818	42132803
Acute kidney injury	59.33	13.49	250	53464	367087	42200534
Bone density decreased	58.99	13.49	36	53678	2170	42565451
Blood phosphorus decreased	58.33	13.49	43	53671	3550	42564071
Decreased appetite	56.72	13.49	427	53287	192710	42374911
Fracture	56.48	13.49	60	53654	8043	42559578
Tooth loss	54.92	13.49	44	53670	4110	42563511
Dental caries	54.82	13.49	47	53667	4825	42562796
Parathyroid tumour malignant	54.49	13.49	14	53700	70	42567551
Jaw operation	54.11	13.49	17	53697	192	42567429
Drug hypersensitivity	53.91	13.49	29	53685	99360	42468261
Dental implantation	52.93	13.49	14	53700	80	42567541
Drug effective for unapproved indication	51.43	13.49	52	53662	6581	42561040
Thoracic vertebral fracture	49.55	13.49	33	53681	2315	42565306
Neoplasm progression	47.80	13.49	110	53604	28890	42538731
Bradycardia	47.76	13.49	24	53690	85460	42482161
Metastases to central nervous system	47.69	13.49	62	53652	10293	42557328
Suture rupture	47.18	13.49	19	53695	459	42567162
SARS-CoV-2 test positive	46.98	13.49	55	53659	8205	42559416
Hungry bone syndrome	46.70	13.49	15	53699	183	42567438
Exostosis of jaw	46.53	13.49	13	53701	94	42567527
Alopecia	46.02	13.49	109	53605	29167	42538454
Product storage error	45.64	13.49	63	53651	11077	42556544
Bone giant cell tumour malignant	45.42	13.49	8	53706	0	42567621
Accidental exposure to product	44.82	13.49	87	53627	20306	42547315
Bone lesion	44.31	13.49	36	53678	3430	42564191
Agitation	44.30	13.49	13	53701	64301	42503320
Peri-implantitis	43.93	13.49	13	53701	118	42567503
Endodontic procedure	43.79	13.49	19	53695	556	42567065
Tachycardia	43.50	13.49	38	53676	101049	42466572
Product use in unapproved indication	43.37	13.49	106	53608	184350	42383271
Tetany	42.38	13.49	23	53691	1109	42566512
Hip fracture	41.98	13.49	67	53647	13405	42554216
Stress fracture	41.89	13.49	22	53692	992	42566629
Asthma	40.43	13.49	14	53700	62300	42505321
Coma	40.39	13.49	9	53705	53545	42514076
Atypical fracture	39.72	13.49	13	53701	169	42567452
Soft tissue disorder	39.52	13.49	20	53694	834	42566787
Gastrointestinal haemorrhage	39.38	13.49	39	53675	97687	42469934
Loose tooth	38.40	13.49	22	53692	1179	42566442
Acetabulum fracture	37.94	13.49	16	53698	436	42567185
Schizophrenia	37.84	13.49	56	53658	10494	42557127
Jaw fistula	37.68	13.49	10	53704	58	42567563
Bone disorder	37.56	13.49	44	53670	6569	42561052
Artificial crown procedure	37.35	13.49	8	53706	14	42567607
Metastases to spine	37.33	13.49	31	53683	3046	42564575
Polyneuropathy in malignant disease	37.30	13.49	15	53699	361	42567260
Neuropathy peripheral	36.80	13.49	237	53477	101616	42466005
Tooth abscess	36.73	13.49	44	53670	6724	42560897
Multiple organ dysfunction syndrome	36.55	13.49	41	53673	96994	42470627
Suicidal ideation	36.51	13.49	8	53706	48153	42519468
Spinal compression fracture	36.34	13.49	46	53668	7437	42560184
Osteosclerosis	36.31	13.49	23	53691	1481	42566140
Chest pain	36.18	13.49	76	53638	139454	42428167
Gingivitis	36.14	13.49	34	53680	3939	42563682
Bone loss	35.58	13.49	17	53697	625	42566996
Jaw fracture	35.04	13.49	20	53694	1064	42566557
Periodontitis	34.86	13.49	26	53688	2185	42565436
Incorrect route of product administration	34.48	13.49	87	53627	24218	42543403
Wheezing	34.36	13.49	13	53701	54768	42512853
Hyperparathyroidism	34.22	13.49	21	53693	1278	42566343
Febrile neutropenia	33.33	13.49	121	53593	185582	42382039
Carcinoid tumour of the small bowel	32.74	13.49	14	53700	395	42567226
Prostate cancer recurrent	32.40	13.49	19	53695	1064	42566557
Septic shock	32.11	13.49	41	53673	91631	42475990
Blood parathyroid hormone decreased	32.07	13.49	22	53692	1621	42566000
Nephrocalcinosis	31.98	13.49	17	53697	786	42566835
Cardio-respiratory arrest	31.95	13.49	17	53697	58619	42509002
Bone fissure	31.75	13.49	10	53704	114	42567507
Somnolence	30.91	13.49	84	53630	141021	42426600
Gingival disorder	30.54	13.49	21	53693	1553	42566068
Metastases to peritoneum	30.39	13.49	25	53689	2424	42565197
Failure to anastomose	29.72	13.49	11	53703	210	42567411
Psoriasis	29.72	13.49	12	53702	48592	42519029
Sequestrectomy	29.62	13.49	11	53703	212	42567409
Anxiety	29.55	13.49	66	53648	118494	42449127
Erysipelas	29.46	13.49	38	53676	6258	42561363
Disease progression	29.22	13.49	293	53421	143363	42424258
Dental fistula	29.03	13.49	9	53705	97	42567524
Blood 1,25-dihydroxycholecalciferol increased	28.92	13.49	7	53707	26	42567595
Abdominal pain	28.62	13.49	133	53581	190338	42377283
Aggression	28.51	13.49	10	53704	44153	42523468
Hyperaesthesia	27.97	13.49	36	53678	5916	42561705
Cellulitis	27.83	13.49	152	53562	61433	42506188
Sedation	27.77	13.49	3	53711	30472	42537149
Carbohydrate antigen 15-3 increased	27.29	13.49	8	53706	70	42567551
Prostatic specific antigen abnormal	27.09	13.49	16	53698	908	42566713
Compression fracture	26.60	13.49	28	53686	3714	42563907
Treatment failure	26.38	13.49	24	53690	62600	42505021
International normalised ratio increased	26.19	13.49	14	53700	48154	42519467
Respiratory failure	26.06	13.49	79	53635	128053	42439568
Bone formation increased	26.04	13.49	5	53709	3	42567618
Spinal pain	25.77	13.49	37	53677	6745	42560876
Ulna fracture	25.77	13.49	12	53702	416	42567205
Pleurocutaneous fistula	25.01	13.49	7	53707	51	42567570
Lumbar vertebral fracture	24.79	13.49	25	53689	3154	42564467
Confusional state	24.60	13.49	118	53596	167479	42400142
Gingival abscess	24.02	13.49	9	53705	178	42567443
Osteonecrosis of external auditory canal	24.01	13.49	7	53707	60	42567561
Lymphocele	23.96	13.49	18	53696	1529	42566092
Neoplasm malignant	23.93	13.49	73	53641	22670	42544951
Eosinophilia	23.88	13.49	6	53708	32893	42534728
Stress	23.82	13.49	13	53701	44199	42523422
Pruritus	23.76	13.49	140	53574	188631	42378990
Hereditary optic atrophy	23.71	13.49	7	53707	63	42567558
Leukopenia	23.45	13.49	168	53546	74578	42493043
Hospice care	23.38	13.49	40	53674	8473	42559148
Coronary artery disease	23.34	13.49	20	53694	53700	42513921
Cardiogenic shock	23.13	13.49	8	53706	35632	42531989
Weight increased	23.11	13.49	65	53649	107918	42459703
Cough	23.00	13.49	131	53583	177972	42389649
Metabolic acidosis	22.90	13.49	19	53695	51839	42515782
Pyrexia	22.63	13.49	355	53359	393687	42173934
Oxygen saturation decreased	22.57	13.49	29	53685	64658	42502963
Extrapyramidal disorder	22.50	13.49	58	53656	16354	42551267
Tooth infection	22.47	13.49	38	53676	7973	42559648
Pseudarthrosis	22.29	13.49	7	53707	79	42567542
Autoimmune disorder	22.08	13.49	21	53693	2466	42565155
Metastases to soft tissue	21.98	13.49	11	53703	448	42567173
Hallucination, auditory	21.92	13.49	54	53660	14810	42552811
Mastication disorder	21.77	13.49	18	53696	1758	42565863
Transfusion-related circulatory overload	21.72	13.49	13	53701	756	42566865
Depression	21.70	13.49	70	53644	111293	42456328
Intentional product use issue	21.36	13.49	36	53678	71797	42495824
Cytokine release syndrome	21.34	13.49	15	53699	44512	42523109
Obstructive airways disorder	21.19	13.49	3	53711	24756	42542865
Lymphocyte count decreased	21.09	13.49	80	53634	27729	42539892
Gingival swelling	21.04	13.49	16	53698	1384	42566237
Macroenzyme creatine kinase	21.00	13.49	5	53709	17	42567604
Tremor	20.99	13.49	58	53656	96871	42470750
Blood calcium increased	20.98	13.49	38	53676	8416	42559205
Acute respiratory distress syndrome	20.89	13.49	6	53708	30102	42537519
Accidental overdose	20.88	13.49	5	53709	28325	42539296
Abnormal behaviour	20.86	13.49	4	53710	26447	42541174
Hypoglycaemia	20.71	13.49	27	53687	59827	42507794
Chest discomfort	20.71	13.49	30	53684	63586	42504035
Product use issue	20.56	13.49	41	53673	76710	42490911
Blood urea increased	20.20	13.49	8	53706	32785	42534836
Respiratory distress	20.16	13.49	14	53700	41806	42525815
Headache	19.98	13.49	199	53515	239170	42328451
Hypersensitivity	19.96	13.49	38	53676	72332	42495289
Loss of personal independence in daily activities	19.92	13.49	20	53694	49796	42517825
Allodynia	19.83	13.49	14	53700	1080	42566541
Arthralgia	19.82	13.49	366	53348	204872	42362749
Dental restoration failure	19.80	13.49	5	53709	23	42567598
Extraskeletal ossification	19.76	13.49	6	53708	60	42567561
Haematochezia	19.57	13.49	27	53687	58409	42509212
Bone fistula	19.46	13.49	5	53709	25	42567596
Neutrophil count increased	19.39	13.49	62	53652	19742	42547879
Dental operation	19.18	13.49	10	53704	444	42567177
Spinal cord compression	19.00	13.49	25	53689	4199	42563422
Palliative care	18.94	13.49	14	53700	1160	42566461
Therapeutic product effect incomplete	18.92	13.49	38	53676	70901	42496720
Injury associated with device	18.90	13.49	15	53699	1382	42566239
Hallucination	18.83	13.49	27	53687	57480	42510141
Splenic artery aneurysm	18.70	13.49	5	53709	30	42567591
Pericoronitis	18.67	13.49	4	53710	7	42567614
Asthenia	18.54	13.49	474	53240	280319	42287302
Anaphylactic reaction	18.46	13.49	16	53698	42727	42524894
Serotonin syndrome	18.21	13.49	5	53709	25840	42541781
Cytomegalovirus infection	18.14	13.49	9	53705	32297	42535324
Shock	18.11	13.49	7	53707	29114	42538507
Abscess oral	18.09	13.49	10	53704	500	42567121
Periodontal disease	17.99	13.49	12	53702	844	42566777
Overdose	17.95	13.49	70	53644	105194	42462427
Calculus urinary	17.86	13.49	16	53698	1741	42565880
Sepsis	17.78	13.49	163	53551	199171	42368450
Neurotoxicity	17.78	13.49	4	53710	23647	42543974
C-telopeptide increased	17.71	13.49	4	53710	10	42567611
Vitamin D increased	17.48	13.49	6	53708	91	42567530
Respiratory arrest	17.40	13.49	7	53707	28417	42539204
Lymphoedema	17.36	13.49	26	53688	4922	42562699
Psoriatic arthropathy	17.27	13.49	5	53709	24962	42542659
Unresponsive to stimuli	17.26	13.49	9	53705	31394	42536227
Hyperparathyroidism secondary	17.21	13.49	16	53698	1826	42565795
Vitamin D deficiency	17.20	13.49	34	53680	8039	42559582
Metastases to skin	17.09	13.49	10	53704	558	42567063
Pulpless tooth	17.03	13.49	3	53711	0	42567621
Calcium ionised abnormal	17.03	13.49	3	53711	0	42567621
Platelet count decreased	16.99	13.49	257	53457	138324	42429297
Generalised tonic-clonic seizure	16.98	13.49	6	53708	26373	42541248
Hallucination, visual	16.96	13.49	3	53711	21017	42546604
Limbic encephalitis	16.79	13.49	9	53705	423	42567198
Hypoxia	16.46	13.49	40	53674	69746	42497875
Prostatic specific antigen decreased	16.45	13.49	7	53707	195	42567426
Orthostatic hypotension	16.45	13.49	9	53705	30561	42537060
Metastases to eye	16.43	13.49	6	53708	110	42567511
Vipoma	16.29	13.49	4	53710	16	42567605
Abdominal distension	16.23	13.49	42	53672	71693	42495928
Medication error	16.11	13.49	11	53703	33143	42534478
Immunoglobulins decreased	16.10	13.49	12	53702	1007	42566614
Dyspnoea	16.07	13.49	430	53284	442191	42125430
Periprosthetic fracture	15.94	13.49	7	53707	211	42567410
Bile acid malabsorption	15.81	13.49	6	53708	123	42567498
Pulmonary hypertension	15.80	13.49	5	53709	23564	42544057
Acute myocardial infarction	15.64	13.49	31	53683	58134	42509487
Rebound effect	15.63	13.49	31	53683	7348	42560273
Drug reaction with eosinophilia and systemic symptoms	15.59	13.49	18	53696	42057	42525564
Myocardial infarction	15.57	13.49	92	53622	123917	42443704
Heart rate increased	15.55	13.49	27	53687	53228	42514393
Paraesthesia	15.48	13.49	151	53563	73308	42494313
Tibia fracture	15.41	13.49	15	53699	1813	42565808
Depressed level of consciousness	15.24	13.49	23	53691	47947	42519674
No adverse event	15.22	13.49	16	53698	39005	42528616
Oral cavity fistula	15.09	13.49	6	53708	140	42567481
Heart valve calcification	14.96	13.49	3	53711	3	42567618
Osteoporosis	14.90	13.49	47	53667	14859	42552762
Traumatic fracture	14.66	13.49	8	53706	390	42567231
Poor peripheral circulation	14.63	13.49	14	53700	1657	42565964
Respiratory depression	14.57	13.49	3	53711	18865	42548756
Appendicitis	14.50	13.49	4	53710	20609	42547012
Bedridden	14.38	13.49	22	53692	4243	42563378
Hepatic cytolysis	14.30	13.49	8	53706	26836	42540785
Postrenal failure	14.29	13.49	9	53705	574	42567047
Disease recurrence	14.22	13.49	10	53704	29668	42537953
Toxic epidermal necrolysis	14.21	13.49	8	53706	26742	42540879
Renal tubular necrosis	14.01	13.49	3	53711	18351	42549270
Nightmare	13.99	13.49	7	53707	25005	42542616
Blood glucose increased	13.89	13.49	47	53667	73652	42493969
Venous thrombosis limb	13.85	13.49	16	53698	2353	42565268
Lower respiratory tract infection	13.84	13.49	19	53695	41187	42526434
Hydrocalyx	13.75	13.49	3	53711	6	42567615
Alanine aminotransferase increased	13.69	13.49	61	53653	88345	42479276
Multiple fractures	13.61	13.49	13	53701	1535	42566086

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	21165.20	10.66	20993	230992	1479192	108858122
Osteonecrosis of jaw	16802.18	10.66	5649	246336	42368	110294946
Death	6662.55	10.66	8045	243940	690824	109646490
Hypocalcaemia	3376.54	10.66	2010	249975	63356	110273958
Bone pain	2057.25	10.66	1472	250513	63661	110273653
Spinal fracture	1926.62	10.66	969	251016	21664	110315650
Tooth disorder	1918.65	10.66	1055	250930	28454	110308860
Atypical femur fracture	1714.95	10.66	614	251371	5605	110331709
Pain in jaw	1518.75	10.66	1114	250871	50063	110287251
Tooth extraction	1481.76	10.66	680	251305	12311	110325003
Back pain	1430.53	10.66	2820	249165	368176	109969138
Metastases to bone	1170.93	10.66	786	251199	30586	110306728
Pain in extremity	1004.44	10.66	2903	249082	484215	109853099
Thoracic vertebral fracture	990.45	10.66	420	251565	6235	110331079
Bone density abnormal	933.54	10.66	347	251638	3556	110333758
Drug ineffective	919.66	10.66	1280	250705	1519260	108818054
Myalgia	841.91	10.66	1679	250306	220702	110116612
Lumbar vertebral fracture	812.47	10.66	403	251582	8728	110328586
Tooth fracture	807.09	10.66	453	251532	12714	110324600
Arthralgia	780.90	10.66	3676	248309	775956	109561358
Toothache	721.42	10.66	523	251462	23052	110314262
Exposed bone in jaw	711.81	10.66	283	251702	3528	110333786
Femur fracture	710.83	10.66	677	251308	43792	110293522
Pathological fracture	689.12	10.66	396	251589	11636	110325678
Toxicity to various agents	675.05	10.66	137	251848	480418	109856896
Bone density decreased	671.76	10.66	432	251553	15610	110321704
Terminal state	650.46	10.66	298	251687	5369	110331945
Spinal compression fracture	639.15	10.66	441	251544	17951	110319363
Blood parathyroid hormone increased	621.89	10.66	265	251720	3983	110333331
Jaw disorder	554.40	10.66	260	251725	4952	110332362
Osteomyelitis	550.65	10.66	539	251446	36061	110301253
Rebound effect	531	10.66	362	251623	14444	110322870
Completed suicide	506.82	10.66	9	251976	242372	110094942
Metastases to liver	489.70	10.66	498	251487	34888	110302426
Condition aggravated	485.07	10.66	577	251408	734259	109603055
Maternal exposure during pregnancy	477.75	10.66	25	251960	254858	110082456
Infusion related reaction	474.04	10.66	140	251845	381022	109956292
Tooth loss	470.44	10.66	269	251716	7827	110329487
Hip fracture	468.88	10.66	485	251500	34666	110302648
Neoplasm progression	467.59	10.66	653	251332	63942	110273372
Investigation	462.98	10.66	181	251804	2151	110335163
Breast cancer metastatic	455.59	10.66	296	251689	10885	110326429
Malignant neoplasm progression	453.93	10.66	1135	250850	173432	110163882
Synovitis	451.48	10.66	49	251936	274043	110063271
Pemphigus	440.47	10.66	10	251975	214560	110122754
Loose tooth	437.07	10.66	191	251794	3062	110334252
Groin pain	435.38	10.66	326	251659	15102	110322212
Blood calcium decreased	417.06	10.66	460	251525	35385	110301929
Drug intolerance	401.20	10.66	213	251772	406299	109931015
Dental implantation	398.92	10.66	121	251864	612	110336702
Product use in unapproved indication	390.46	10.66	271	251714	447106	109890208
Anti-cyclic citrullinated peptide antibody positive	387.91	10.66	5	251980	181979	110155335
Treatment failure	386.99	10.66	80	251905	277154	110060160
Bone loss	386.65	10.66	172	251813	2883	110334431
Drug abuse	377.60	10.66	5	251980	177406	110159908
Systemic lupus erythematosus	377.25	10.66	63	251922	254275	110083039
Fracture	376.50	10.66	367	251618	24421	110312893
Drug interaction	375.37	10.66	352	251633	499831	109837483
Contraindicated product administered	362.73	10.66	64	251921	248203	110089111
Helicobacter infection	360.24	10.66	12	251973	181865	110155449
Duodenal ulcer perforation	358.20	10.66	10	251975	177690	110159624
Dental caries	356.21	10.66	268	251717	12505	110324809
Bone disorder	350.76	10.66	329	251656	20863	110316451
Hospitalisation	348.06	10.66	905	251080	141588	110195726
Exposure during pregnancy	346.78	10.66	7	251978	167417	110169897
Pericarditis	341.61	10.66	47	251938	219067	110118247
Dental care	336.35	10.66	117	251868	972	110336342
Drug hypersensitivity	327.41	10.66	331	251654	453759	109883555
Acute kidney injury	326.09	10.66	594	251391	634836	109702478
Folliculitis	318.72	10.66	15	251970	167638	110169676
Hand deformity	309.19	10.66	61	251924	218445	110118869
Product storage error	308.32	10.66	310	251675	21418	110315896
Exostosis of jaw	307.12	10.66	113	251872	1122	110336192
Prostatic specific antigen increased	306.33	10.66	243	251742	12268	110325046
Hepatic enzyme increased	303.71	10.66	177	251808	320715	110016599
Confusional state	296.21	10.66	380	251605	468300	109869014
Foot fracture	295.73	10.66	327	251658	25219	110312095
Metastases to lung	292.87	10.66	310	251675	22753	110314561
Hypercalcaemia	291.51	10.66	440	251545	46217	110291097
Psoriatic arthropathy	291.18	10.66	49	251936	196712	110140602
Glossodynia	289.98	10.66	74	251911	221930	110115384
Therapeutic product effect decreased	287.14	10.66	99	251886	244217	110093097
Metastases to lymph nodes	285.26	10.66	252	251733	14780	110322534
Intentional overdose	285.26	10.66	3	251982	132498	110204816
Accidental exposure to product	283.63	10.66	451	251534	49557	110287757
Wheezing	280.60	10.66	115	251870	255115	110082199
Osteonecrosis	279.03	10.66	364	251621	33377	110303937
Muscle injury	276.35	10.66	10	251975	140797	110196517
Rheumatoid factor positive	274.65	10.66	5	251980	131635	110205679
Product use issue	272.88	10.66	188	251797	311507	110025807
Wound	270.37	10.66	98	251887	234339	110102975
Compression fracture	270.23	10.66	200	251785	9099	110328215
Hypotension	264.79	10.66	494	251491	523355	109813959
Hypophosphataemia	263.63	10.66	351	251634	32831	110304483
Osteonecrosis of external auditory canal	255.65	10.66	68	251917	190	110337124
Jaw operation	254.23	10.66	89	251896	755	110336559
Endodontic procedure	251.41	10.66	129	251856	3007	110334307
Fall	251.16	10.66	2283	249702	601199	109736115
C-reactive protein abnormal	248.48	10.66	11	251974	129684	110207630
Type 2 diabetes mellitus	247.55	10.66	51	251934	177181	110160133
Atypical fracture	245.99	10.66	92	251893	960	110336354
Osteitis	244.95	10.66	141	251844	4155	110333159
Liver injury	239.85	10.66	30	251955	150383	110186931
Periodontitis	227.34	10.66	144	251841	5064	110332250
Stress fracture	222.71	10.66	161	251824	7060	110330254
Tooth abscess	220.06	10.66	242	251743	18547	110318767
Breast cancer	217.74	10.66	347	251638	38195	110299119
Joint swelling	214.65	10.66	428	251557	442417	109894897
Overdose	214.09	10.66	134	251851	233660	110103654
Abscess jaw	213.25	10.66	97	251888	1717	110335597
Pelvic fracture	204.60	10.66	204	251781	13950	110323364
Irritable bowel syndrome	202.73	10.66	61	251924	164154	110173160
Metastases to central nervous system	200.99	10.66	254	251731	22563	110314751
Spinal pain	200.63	10.66	229	251756	18286	110319028
Blood calcium increased	200.37	10.66	226	251759	17814	110319500
Intentional product use issue	198.37	10.66	164	251821	247742	110089572
Wrist fracture	197.80	10.66	202	251783	14215	110323099
Facet joint syndrome	196.79	10.66	5	251980	96823	110240491
Gingivitis	193.66	10.66	172	251813	10159	110327155
Cardiac arrest	192.60	10.66	104	251881	196649	110140665
Injury	189.78	10.66	83	251902	177182	110160132
Gingival disorder	189.24	10.66	118	251867	4035	110333279
Intercepted product administration error	188.48	10.66	72	251913	800	110336514
Suicide attempt	187.96	10.66	12	251973	103382	110233932
Multiple fractures	181.99	10.66	156	251829	8784	110328530
Temporomandibular joint syndrome	181.54	10.66	112	251873	3757	110333557
Lower respiratory tract infection	179.89	10.66	173	251812	242933	110094381
Carbohydrate antigen 15-3 increased	177.58	10.66	82	251903	1505	110335809
Lip dry	169.62	10.66	16	251969	100067	110237247
Bradycardia	169.37	10.66	71	251914	155446	110181868
Rib fracture	165.20	10.66	285	251700	33485	110303829
Breast cancer stage III	165.05	10.66	3	251982	79114	110258200
Tooth infection	164.32	10.66	227	251758	21989	110315325
Swollen joint count increased	163.94	10.66	6	251979	83655	110253659
Cystitis	163.81	10.66	422	251563	65614	110271700
Blood calcium abnormal	163.09	10.66	80	251905	1689	110335625
Tetany	160.69	10.66	101	251884	3503	110333811
Sequestrectomy	159.33	10.66	63	251922	773	110336541
Tachycardia	158.89	10.66	169	251816	226476	110110838
Somnolence	158.67	10.66	271	251714	297178	110040136
Obesity	157.48	10.66	33	251952	113318	110223996
Weight increased	157.17	10.66	464	251521	419180	109918134
Febrile neutropenia	151.82	10.66	308	251677	316459	110020855
Coma	150.61	10.66	41	251944	117828	110219486
Gingival swelling	148.98	10.66	112	251873	5218	110332096
Swelling	147.32	10.66	367	251618	350674	109986640
Hypersensitivity	145.35	10.66	455	251530	403543	109933771
Tumour marker increased	145.17	10.66	108	251877	4952	110332362
Abdominal discomfort	144.95	10.66	439	251546	393419	109943895
Gingival recession	142.78	10.66	70	251915	1476	110335838
Metastases to spine	142.12	10.66	109	251876	5234	110332080
Occupational exposure to product	141.84	10.66	58	251927	781	110336533
Artificial crown procedure	140.29	10.66	45	251940	282	110337032
Hyperaesthesia teeth	139.88	10.66	79	251906	2243	110335071
Pyrexia	135.92	10.66	1350	250635	896915	109440399
Fibromyalgia	135.53	10.66	114	251871	170795	110166519
Musculoskeletal discomfort	133.06	10.66	212	251773	23326	110313988
Musculoskeletal pain	132.66	10.66	791	251194	182232	110155082
Prescribed overdose	131.34	10.66	21	251964	87560	110249754
Blister	128.88	10.66	199	251786	227177	110110137
Dental restoration failure	127.51	10.66	59	251926	1088	110336226
Gingival pain	127.36	10.66	168	251817	15568	110321746
Asthma	127.18	10.66	235	251750	250056	110087258
Vomiting	126.23	10.66	1397	250588	909278	109428036
Oedema	125.62	10.66	177	251808	209799	110127515
Upper limb fracture	123.43	10.66	192	251793	20696	110316618
Lactic acidosis	122.95	10.66	30	251955	92781	110244533
Depressed level of consciousness	122.67	10.66	51	251934	112227	110225087
Femoral neck fracture	122.13	10.66	147	251838	12420	110324894
Deep vein thrombosis postoperative	120.71	10.66	3	251982	59288	110278026
Vitamin D decreased	120.54	10.66	144	251841	12071	110325243
Dental operation	119.03	10.66	61	251924	1418	110335896
Cardio-respiratory arrest	118.14	10.66	58	251927	115778	110221536
Multiple organ dysfunction syndrome	118.09	10.66	103	251882	151607	110185707
Suicidal ideation	117.55	10.66	34	251951	93903	110243411
Hot flush	117.10	10.66	374	251611	65662	110271652
Prostate cancer metastatic	116.72	10.66	94	251891	4849	110332465
Hyperparathyroidism	115.34	10.66	84	251901	3726	110333588
Agitation	113.20	10.66	58	251927	112993	110224321
Muscle spasms	112.18	10.66	1046	250939	277111	110060203
Mastication disorder	111.67	10.66	80	251905	3458	110333856
Neutropenia	111.65	10.66	1325	250660	373295	109964019
Incorrect route of product administration	111.04	10.66	360	251625	63701	110273613
Dyspnoea	110.95	10.66	1815	250170	1105057	109232257
Bone lesion	107.74	10.66	105	251880	6982	110330332
Abdominal pain	107.35	10.66	706	251279	512283	109825031
Serotonin syndrome	107.11	10.66	7	251978	59146	110278168
Bedridden	106.61	10.66	142	251843	13283	110324031
Neoplasm malignant	106.56	10.66	251	251734	36892	110300422
Metabolic acidosis	106.27	10.66	47	251938	99697	110237617
White blood cell count decreased	106.12	10.66	889	251096	228501	110108813
Peripheral venous disease	106.08	10.66	30	251955	84087	110253227
Parathyroid tumour malignant	105.24	10.66	31	251954	139	110337175
Oral pain	103.07	10.66	249	251736	37195	110300119
Sleep disorder due to general medical condition, insomnia type	101.67	10.66	57	251928	105586	110231728
Unresponsive to stimuli	101	10.66	13	251972	63777	110273537
Fractured sacrum	100.80	10.66	61	251924	1975	110335339
Blepharospasm	97.83	10.66	7	251978	54844	110282470
Delirium	97.64	10.66	98	251887	134927	110202387
Influenza like illness	97.60	10.66	430	251555	87982	110249332
Gastrointestinal haemorrhage	97.53	10.66	141	251844	165377	110171937
Product quality issue	96.68	10.66	28	251957	77271	110260043
Humerus fracture	96.56	10.66	121	251864	10655	110326659
Jaw fistula	96.08	10.66	28	251957	120	110337194
Blood phosphorus decreased	95.49	10.66	102	251883	7563	110329751
International normalised ratio increased	95.46	10.66	39	251946	86733	110250581
Pulmonary fibrosis	95.44	10.66	57	251928	101985	110235329
Tibia fracture	93.50	10.66	94	251891	6491	110330823
Bone giant cell tumour malignant	91.56	10.66	18	251967	0	110337314
Rash pruritic	91.39	10.66	454	251531	97615	110239699
Rheumatoid arthritis	91.24	10.66	362	251623	299251	110038063
Body height decreased	90.52	10.66	116	251869	10447	110326867
Grip strength decreased	89.89	10.66	35	251950	80139	110257175
Dermatitis	89.72	10.66	197	251788	27640	110309674
Inflammation	88.25	10.66	193	251792	193045	110144269
Respiratory failure	88.05	10.66	228	251757	215104	110122210
Sinusitis	87.50	10.66	363	251622	296325	110040989
Discomfort	87.29	10.66	228	251757	214479	110122835
Eczema	87.04	10.66	361	251624	71932	110265382
Dental fistula	86.76	10.66	37	251948	557	110336757
Hypoglycaemia	86.57	10.66	82	251903	116022	110221292
Musculoskeletal chest pain	86.10	10.66	198	251787	28649	110308665
Hypercholesterolaemia	86.00	10.66	50	251935	90787	110246527
Hypoxia	85.89	10.66	101	251884	129414	110207900
Metastasis	85.79	10.66	100	251885	8167	110329147
Migraine	85.56	10.66	163	251822	171489	110165825
Arthropathy	85.28	10.66	351	251634	287171	110050143
Anaphylactic reaction	84.90	10.66	81	251904	114219	110223095
Osteoporotic fracture	84.77	10.66	81	251904	5256	110332058
Drug ineffective for unapproved indication	84.75	10.66	66	251919	102772	110234542
Wound infection	84.58	10.66	58	251927	96407	110240907
Hospice care	84.18	10.66	122	251863	12351	110324963
Lymphoedema	83.75	10.66	134	251851	14795	110322519
Pneumonia	83.34	10.66	1451	250534	875263	109462051
Urinary tract infection	82.28	10.66	1119	250866	325163	110012151
C-telopeptide increased	80.75	10.66	19	251966	25	110337289
Hungry bone syndrome	80.56	10.66	30	251955	309	110337005
Tooth erosion	80.11	10.66	32	251953	404	110336910
Dislocation of vertebra	79.68	10.66	5	251980	43716	110293598
Gingival abscess	79.37	10.66	42	251943	1045	110336269
Respiratory arrest	78.89	10.66	18	251967	58281	110279033
Red blood cell sedimentation rate increased	78.65	10.66	40	251945	78262	110259052
Infection	78.51	10.66	493	251492	361707	109975607
Product dose omission issue	78.06	10.66	1096	250889	320686	110016628
Lung disorder	78.01	10.66	185	251800	179862	110157452
Radius fracture	77.78	10.66	68	251917	3932	110333382
Joint range of motion decreased	76.59	10.66	99	251886	121733	110215581
Bursitis	76.21	10.66	111	251874	129807	110207507
Encephalopathy	76.19	10.66	45	251940	81010	110256304
Drug level increased	74.89	10.66	10	251975	47709	110289605
Parathyroid tumour benign	74.52	10.66	40	251945	1025	110336289
Jaw fracture	74.49	10.66	60	251925	3096	110334218
Eosinophilia	74.29	10.66	20	251965	57916	110279398
Cancer pain	73.78	10.66	84	251901	6688	110330626
X-ray abnormal	73.77	10.66	3	251982	38114	110299200
Delusion of grandeur	73.40	10.66	52	251933	2208	110335106
PIK3CA-activated mutation	72.90	10.66	34	251951	639	110336675
No adverse event	72.27	10.66	39	251946	73800	110263514
Cytokine release syndrome	71.99	10.66	35	251950	70271	110267043
Toxic epidermal necrolysis	71.96	10.66	20	251965	56707	110280607
Bone sequestrum	71.72	10.66	41	251944	1192	110336122
Ventricular fibrillation	71.63	10.66	6	251979	41307	110296007
Periodontal disease	71.46	10.66	49	251936	1973	110335341
Aggression	71.25	10.66	23	251962	59187	110278127
Colitis ulcerative	71.25	10.66	44	251941	77319	110259995
Musculoskeletal stiffness	70.83	10.66	362	251623	279460	110057854
Anxiety	70.07	10.66	479	251506	344599	109992715
Drug-induced liver injury	70.02	10.66	103	251882	119964	110217350
Adjustment disorder with depressed mood	69.34	10.66	9	251976	43874	110293440
Intentional self-injury	69.06	10.66	4	251981	37425	110299889
Osteosclerosis	68.84	10.66	67	251918	4448	110332866
Joint noise	68.63	10.66	71	251914	5072	110332242
Pulpitis dental	68.03	10.66	43	251942	1506	110335808
Dental necrosis	67.64	10.66	22	251963	145	110337169
Dental cleaning	67.51	10.66	15	251970	12	110337302
Oxygen saturation decreased	67.45	10.66	162	251823	156820	110180494
Prescribed underdose	67.41	10.66	32	251953	65142	110272172
Scoliosis	67.25	10.66	91	251894	8642	110328672
Psoriasis	67.11	10.66	136	251849	139857	110197457
Night sweats	66.96	10.66	127	251858	133856	110203458
Hyponatraemia	66.86	10.66	262	251723	217391	110119923
Road traffic accident	66.76	10.66	88	251897	107310	110230004
Haematochezia	66.50	10.66	100	251885	115424	110221890
Chest pain	66.17	10.66	544	251441	375831	109961483
Hyperparathyroidism secondary	65.92	10.66	57	251928	3247	110334067
Rhabdomyolysis	65.71	10.66	108	251877	120293	110217021
Gait disturbance	65.22	10.66	942	251043	277266	110060048
Multiple sclerosis relapse	65.07	10.66	17	251968	50223	110287091
Septic shock	65.00	10.66	166	251819	157362	110179952
Neuroleptic malignant syndrome	64.86	10.66	3	251982	34056	110303258
Therapy non-responder	64.73	10.66	166	251819	157141	110180173
Seizure	64.34	10.66	272	251713	220913	110116401
Cardiogenic shock	64.33	10.66	25	251960	57313	110280001
Medication error	63.81	10.66	88	251897	105278	110232036
Lymphocyte count abnormal	63.45	10.66	49	251936	2377	110334937
Therapeutic product effect incomplete	63.40	10.66	278	251707	223527	110113787
Muscle spasticity	62.87	10.66	5	251980	35910	110301404
Abortion spontaneous	62.24	10.66	4	251981	34278	110303036
Dysarthria	62.02	10.66	60	251925	84061	110253253
Hand fracture	61.58	10.66	84	251901	8038	110329276
Hallucination	61.14	10.66	85	251900	101347	110235967
C-reactive protein increased	60.94	10.66	272	251713	217647	110119667
Inappropriate schedule of product administration	60.92	10.66	721	251264	202916	110134398
Cytomegalovirus infection	60.65	10.66	24	251961	54420	110282894
Nasopharyngitis	60.56	10.66	590	251395	393771	109943543
Ulna fracture	60.51	10.66	37	251948	1221	110336093
Intentional product misuse	60.45	10.66	133	251852	132771	110204543
Liver disorder	60.16	10.66	148	251837	142095	110195219
Hyperkalaemia	60.05	10.66	138	251847	135658	110201656
Feeling abnormal	60.00	10.66	653	251332	180058	110157256
Hypophosphatasia	59.79	10.66	19	251966	115	110337199
Tooth resorption	59.56	10.66	15	251970	31	110337283
Injection site reaction	59.55	10.66	69	251916	89001	110248313
Vitamin D deficiency	59.46	10.66	131	251854	18421	110318893
Generalised tonic-clonic seizure	59.46	10.66	25	251960	54655	110282659
Dry skin	59.00	10.66	434	251551	107219	110230095
Denture wearer	58.71	10.66	18	251967	95	110337219
Peri-implantitis	58.41	10.66	21	251964	194	110337120
Oral cavity fistula	57.22	10.66	29	251956	658	110336656
Mouth swelling	57.19	10.66	77	251908	7277	110330037
Pain	57.18	10.66	2691	249294	952264	109385050
Cholesteatoma	55.99	10.66	20	251965	181	110337133
Osteoporosis	55.20	10.66	364	251621	86788	110250526
Device expulsion	54.93	10.66	4	251981	30887	110306427
Hormone-refractory prostate cancer	54.92	10.66	31	251954	879	110336435
Carcinoembryonic antigen increased	54.89	10.66	48	251937	2776	110334538
Parathyroid disorder	54.79	10.66	28	251957	647	110336667
Rectal haemorrhage	53.62	10.66	121	251864	119712	110217602
Drug reaction with eosinophilia and systemic symptoms	53.38	10.66	65	251920	82030	110255284
Cellulitis	53.34	10.66	479	251506	125537	110211777
Headache	53.13	10.66	1568	250417	880809	109456505
Accidental overdose	52.77	10.66	26	251959	51808	110285506
Hepatitis	52.76	10.66	77	251908	89977	110247337
Gastrointestinal disorder	52.56	10.66	329	251656	241623	110095691
Sedation	52.19	10.66	49	251936	69634	110267680
Obstructive airways disorder	51.97	10.66	20	251965	46129	110291185
Oral infection	51.61	10.66	68	251917	6293	110331021
Unevaluable event	51.54	10.66	269	251716	58958	110278356
Poisoning	51.09	10.66	4	251981	29101	110308213
Drug withdrawal syndrome	50.99	10.66	12	251973	38042	110299272
Bone erosion	50.74	10.66	21	251964	46350	110290964
Ill-defined disorder	50.64	10.66	185	251800	156668	110180646
Liver function test increased	50.62	10.66	77	251908	88471	110248843
Chest discomfort	50.42	10.66	214	251771	173634	110163680
Osteolysis	49.46	10.66	62	251923	5461	110331853
Polymyalgia rheumatica	49.41	10.66	67	251918	6375	110330939
Blood parathyroid hormone abnormal	49.17	10.66	22	251963	374	110336940
Spinal operation	49.02	10.66	89	251896	10883	110326431
Dental discomfort	48.95	10.66	24	251961	506	110336808
Mental status changes	48.73	10.66	61	251924	76061	110261253
C-reactive protein	48.46	10.66	6	251979	30325	110306989
Epilepsy	48.33	10.66	97	251888	100112	110237202
Intervertebral disc protrusion	48.30	10.66	156	251829	27542	110309772
Device failure	47.92	10.66	70	251915	7137	110330177
Menopausal symptoms	47.59	10.66	42	251943	2459	110334855
Parathyroid tumour	47.49	10.66	14	251971	63	110337251
Fatigue	47.48	10.66	3296	248689	1212662	109124652
Frequent bowel movements	46.97	10.66	56	251929	71334	110265980
Living in residential institution	46.76	10.66	29	251956	982	110336332
Premature delivery	46.71	10.66	7	251978	30625	110306689
Wrong technique in product usage process	46.64	10.66	350	251635	86998	110250316
Musculoskeletal disorder	46.38	10.66	135	251850	22529	110314785
Therapeutic response decreased	46.03	10.66	94	251891	96405	110240909
Spinal deformity	45.97	10.66	31	251954	1214	110336100
Autoimmune disorder	45.67	10.66	49	251936	65434	110271880
Neuropathy peripheral	45.61	10.66	616	251369	178661	110158653
Lupus-like syndrome	45.41	10.66	18	251967	40774	110296540
Acute respiratory distress syndrome	45.30	10.66	33	251952	53165	110284149
Disease progression	45.01	10.66	794	251191	243240	110094074
Onychomadesis	44.86	10.66	24	251961	45639	110291675
Oral discomfort	44.62	10.66	87	251898	11224	110326090
Metastases to skin	44.54	10.66	39	251946	2260	110335054
Tachypnoea	44.49	10.66	17	251968	39378	110297936
Depression	43.70	10.66	487	251498	316848	110020466
Nightmare	43.51	10.66	17	251968	38846	110298468
Agranulocytosis	43.31	10.66	46	251939	61714	110275600
Blood creatine phosphokinase increased	43.28	10.66	62	251923	73015	110264299
Tubulointerstitial nephritis	43.27	10.66	36	251949	54248	110283066
Respiratory depression	43.06	10.66	10	251975	31991	110305323
Bronchopulmonary aspergillosis	42.93	10.66	8	251977	29855	110307459
Sinus tachycardia	42.81	10.66	24	251961	44469	110292845
Kyphosis	42.53	10.66	44	251941	3143	110334171
Breast cancer recurrent	42.40	10.66	48	251937	3798	110333516
Noninfective gingivitis	42.39	10.66	36	251949	2001	110335313
Vitamin D abnormal	42.39	10.66	17	251968	217	110337097
Dementia	41.99	10.66	163	251822	31510	110305804
Parathyroidectomy	41.97	10.66	18	251967	275	110337039
Nerve compression	41.93	10.66	84	251901	11053	110326261
Dry mouth	41.83	10.66	275	251710	199673	110137641
Labelled drug-drug interaction medication error	41.80	10.66	8	251977	29294	110308020
Urticaria	41.70	10.66	495	251490	318362	110018952
Hypertension	41.63	10.66	866	251119	509218	109828096
Rhinalgia	41.56	10.66	48	251937	3881	110333433
Hypoaesthesia oral	41.48	10.66	108	251877	16894	110320420
Ankle fracture	41.47	10.66	119	251866	19700	110317614
Transplant rejection	41.43	10.66	4	251981	24563	110312751
Respiratory distress	41.22	10.66	58	251927	68816	110268498
Peripheral swelling	41.10	10.66	660	251325	403374	109933940
Disease recurrence	40.72	10.66	47	251938	60737	110276577
Mobility decreased	40.46	10.66	763	251222	236659	110100655
Alanine aminotransferase increased	40.37	10.66	249	251736	183524	110153790
Metastases to meninges	40.35	10.66	54	251931	5074	110332240
Circulatory collapse	40.22	10.66	24	251961	42969	110294345
Product label confusion	40.14	10.66	3	251982	22674	110314640
Renal tubular necrosis	40.07	10.66	10	251975	30465	110306849
Loss of consciousness	40.06	10.66	272	251713	196034	110141280
White blood cell count increased	39.98	10.66	102	251883	96740	110240574
Bone graft	39.88	10.66	24	251961	769	110336545
Blood 1,25-dihydroxycholecalciferol increased	39.80	10.66	13	251972	87	110337227
Product prescribing error	39.75	10.66	35	251950	51296	110286018
Onychomycosis	39.72	10.66	19	251966	38512	110298802
Acetabulum fracture	39.72	10.66	26	251959	968	110336346
Dental prosthesis placement	39.28	10.66	10	251975	22	110337292
Pleural neoplasm	39.00	10.66	19	251966	395	110336919
Acute myeloid leukaemia	38.97	10.66	19	251966	38091	110299223
Aspergillus infection	38.72	10.66	6	251979	25610	110311704
Dental prosthesis user	38.68	10.66	10	251975	24	110337290
Varicose vein	38.53	10.66	62	251923	6878	110330436
Coronary artery disease	38.47	10.66	65	251920	71625	110265689
Status epilepticus	38.45	10.66	12	251973	31559	110305755
Mastectomy	38.39	10.66	30	251955	1481	110335833
Drug tolerance decreased	38.28	10.66	8	251977	27532	110309782
Angioedema	38.20	10.66	107	251878	98393	110238921
Metastases to peritoneum	38.04	10.66	55	251930	5555	110331759
Erysipelas	37.83	10.66	89	251896	13069	110324245
Prostate cancer	37.75	10.66	178	251807	37463	110299851
Bone swelling	37.52	10.66	32	251953	1789	110335525
Shock	37.48	10.66	40	251945	53548	110283766
Pancytopenia	37.25	10.66	302	251683	209311	110128003
Pancreatitis	36.73	10.66	101	251884	93432	110243882
Onychoclasis	36.61	10.66	62	251923	7175	110330139
Breast disorder	36.52	10.66	35	251950	2279	110335035
Circumstance or information capable of leading to medication error	36.51	10.66	52	251933	5181	110332133
Ventricular tachycardia	36.48	10.66	36	251949	49973	110287341
Mydriasis	36.35	10.66	4	251981	22153	110315161
Stevens-Johnson syndrome	36.29	10.66	32	251953	46869	110290445
Abnormal behaviour	36.23	10.66	22	251963	39017	110298297
Fluid retention	36.17	10.66	103	251882	94204	110243110
Abdominal pain upper	35.93	10.66	569	251416	348542	109988772
Sleep disorder	35.85	10.66	285	251700	198359	110138955
Polyneuropathy in malignant disease	35.57	10.66	19	251966	482	110336832
Muscle tightness	35.22	10.66	93	251892	14669	110322645
Drug dose omission by device	35.20	10.66	92	251893	14424	110322890
Hemiparesis	35.14	10.66	29	251956	43874	110293440
Blood pressure decreased	35.04	10.66	139	251846	114952	110222362
Intercepted medication error	34.99	10.66	26	251959	1190	110336124
Torsade de pointes	34.84	10.66	5	251980	22595	110314719
Hepatic cirrhosis	34.76	10.66	63	251922	67563	110269751
Oral surgery	34.71	10.66	28	251957	1448	110335866
Orthostatic hypotension	34.70	10.66	61	251924	66188	110271126
Hyperparathyroidism primary	34.60	10.66	19	251966	510	110336804
Bone cancer	34.60	10.66	35	251950	2435	110334879
Paranoia	34.38	10.66	5	251980	22369	110314945
Activated partial thromboplastin time prolonged	34.36	10.66	5	251980	22363	110314951
Red blood cell sedimentation rate abnormal	34.31	10.66	7	251978	24502	110312812
Emotional distress	34.22	10.66	31	251954	44816	110292498
Hyperhidrosis	34.13	10.66	268	251717	187030	110150284
Sedation complication	34.10	10.66	3	251982	19852	110317462
Coagulopathy	34.03	10.66	26	251959	40885	110296429
Renal failure	33.90	10.66	341	251644	226233	110111081
Sepsis	33.86	10.66	533	251452	326813	110010501
Cataract operation	33.27	10.66	53	251932	5830	110331484
Right ventricular failure	33.20	10.66	9	251976	25945	110311369
Hepatic lesion	33.11	10.66	65	251920	8428	110328886
Blood alkaline phosphatase decreased	32.98	10.66	34	251951	2419	110334895
Tremor	32.96	10.66	298	251687	201934	110135380
Paraesthesia	32.88	10.66	844	251141	275677	110061637
Coeliac disease	32.78	10.66	30	251955	43157	110294157
Periprosthetic fracture	32.71	10.66	21	251964	756	110336558
Trismus	32.69	10.66	56	251929	6540	110330774
Staphylococcal infection	32.63	10.66	69	251916	69875	110267439
Abscess oral	32.59	10.66	28	251957	1581	110335733
Rheumatoid nodule	32.46	10.66	4	251981	20292	110317022
Tartrate-resistant acid phosphatase increased	32.45	10.66	7	251978	4	110337310
Gingival erythema	32.13	10.66	23	251962	993	110336321
Drug effective for unapproved indication	31.54	10.66	87	251898	14080	110323234
Syncope	31.48	10.66	302	251683	202234	110135080
Product substitution issue	31.44	10.66	7	251978	23054	110314260
Metaphyseal corner fracture	31.38	10.66	9	251976	36	110337278
Drug resistance	31.29	10.66	50	251935	56324	110280990
Bone resorption test abnormal	31.29	10.66	7	251978	6	110337308
Traumatic fracture	31.26	10.66	24	251961	1154	110336160
Diverticulitis	31.18	10.66	219	251766	53303	110284011
Haemoptysis	31.15	10.66	73	251912	71281	110266033
Dysgeusia	31.15	10.66	269	251716	69716	110267598
Limb discomfort	31.14	10.66	179	251806	40675	110296639
Haemodynamic instability	31.10	10.66	7	251978	22881	110314433
Lung neoplasm malignant	31.04	10.66	156	251829	33686	110303628
Bone cancer metastatic	31	10.66	15	251970	307	110337007
Ataxia	30.80	10.66	15	251970	30093	110307221
Forearm fracture	30.46	10.66	19	251966	650	110336664
Haematemesis	30.44	10.66	55	251930	59053	110278261
Calcinosis	30.43	10.66	35	251950	2817	110334497
Laryngitis	30.40	10.66	31	251954	42380	110294934
Parathyroid hormone-related protein increased	30.29	10.66	7	251978	8	110337306
Hypothermia	30.29	10.66	11	251974	26291	110311023
Dysstasia	30.22	10.66	152	251833	32834	110304480
Aspartate aminotransferase increased	30.01	10.66	227	251758	159709	110177605
Paronychia	29.76	10.66	73	251912	11008	110326306
Weight bearing difficulty	29.58	10.66	39	251946	3612	110333702
Infusion site reaction	29.50	10.66	3	251982	17679	110319635
Dyskinesia	29.15	10.66	45	251940	51401	110285913
Delusion	28.98	10.66	9	251976	23746	110313568
Tumour marker abnormal	28.91	10.66	14	251971	287	110337027
Immobile	28.89	10.66	58	251927	7644	110329670
Nail bed inflammation	28.86	10.66	29	251956	2001	110335313
Neck pain	28.85	10.66	417	251568	122713	110214601
Thyroid mass	28.83	10.66	46	251939	5067	110332247
General physical health deterioration	28.80	10.66	743	251242	424552	109912762
Bone fistula	28.75	10.66	10	251975	83	110337231
Cyanosis	28.68	10.66	16	251969	29725	110307589
Neoplasm	28.68	10.66	72	251913	11015	110326299
Cataract	28.61	10.66	292	251693	79193	110258121
Vitamin D increased	28.57	10.66	20	251965	833	110336481
Aphasia	28.54	10.66	57	251928	58940	110278374
Hypercalciuria	28.08	10.66	17	251968	551	110336763
Pulmonary arterial hypertension	27.99	10.66	20	251965	32548	110304766
Pelvic pain	27.99	10.66	90	251895	15852	110321462
Patella fracture	27.98	10.66	31	251954	2395	110334919
Hyperthermia	27.93	10.66	7	251978	21265	110316049
Irritability	27.88	10.66	41	251944	47768	110289546
Heart rate decreased	27.77	10.66	96	251889	82660	110254654
Gingival operation	27.74	10.66	11	251974	136	110337178
Ear pain	27.70	10.66	212	251773	53014	110284300
Palliative care	27.64	10.66	26	251959	1654	110335660
Abdominal lymphadenopathy	27.63	10.66	27	251958	1801	110335513
Acute myocardial infarction	27.57	10.66	98	251887	83679	110253635
Dizziness	27.54	10.66	1305	250680	696888	109640426
SARS-CoV-2 test positive	27.40	10.66	93	251892	16842	110320472
Rehabilitation therapy	27.35	10.66	29	251956	2132	110335182
Gingival injury	27.32	10.66	8	251977	35	110337279
Hip surgery	27.30	10.66	40	251945	4090	110333224
Immune system disorder	27.23	10.66	80	251905	13421	110323893
Metastases to bladder	27.18	10.66	14	251971	329	110336985
Bone marrow failure	27.04	10.66	57	251928	57791	110279523
Pollakiuria	27.03	10.66	183	251802	44012	110293302
Oral disorder	27.01	10.66	74	251911	11929	110325385
Rotator cuff syndrome	26.98	10.66	92	251893	16702	110320612
Nasal mucosal disorder	26.96	10.66	27	251958	1856	110335458
Suture rupture	26.92	10.66	18	251967	695	110336619
Vertebroplasty	26.84	10.66	14	251971	338	110336976
Pseudomonas infection	26.83	10.66	15	251970	27838	110309476
Bone formation increased	26.73	10.66	9	251976	67	110337247
Liver function test abnormal	26.66	10.66	75	251910	68875	110268439
Carbohydrate antigen 27.29 increased	26.60	10.66	10	251975	106	110337208
Rash papular	26.48	10.66	129	251856	27510	110309804
Respiratory rate increased	26.43	10.66	12	251973	25071	110312243
Streptococcal sepsis	26.38	10.66	44	251941	5028	110332286
Upper gastrointestinal haemorrhage	26.35	10.66	46	251939	50050	110287264
Back injury	26.34	10.66	42	251943	47357	110289957
Oedema peripheral	26.19	10.66	560	251425	328100	110009214
Acute respiratory failure	26.15	10.66	86	251899	75174	110262140
Pallor	26.09	10.66	56	251929	56411	110280903
Bone deformity	26.07	10.66	14	251971	359	110336955
Bronchiectasis	25.79	10.66	27	251958	36466	110300848
Amnesia	25.73	10.66	138	251847	105270	110232044
Neuroglycopenia	25.72	10.66	21	251964	1105	110336209
Diabetic ketoacidosis	25.59	10.66	35	251950	42023	110295291
Breath sounds abnormal	25.47	10.66	13	251972	25391	110311923
Lichen planus	25.45	10.66	35	251950	3375	110333939
Oral neoplasm benign	25.43	10.66	5	251980	0	110337314
Calcium ionised abnormal	25.43	10.66	5	251980	0	110337314
Scab	25.34	10.66	77	251908	13159	110324155
Hormone receptor positive HER2 negative breast cancer	25.33	10.66	12	251973	234	110337080
Pancreatitis acute	25.25	10.66	63	251922	60211	110277103
Coordination abnormal	25.16	10.66	13	251972	25215	110312099
Pulseless electrical activity	25.16	10.66	4	251981	16753	110320561
Post transplant lymphoproliferative disorder	25.16	10.66	3	251982	15610	110321704
Posterior reversible encephalopathy syndrome	25.13	10.66	24	251961	33837	110303477
Chronic sinusitis	24.91	10.66	13	251972	25071	110312243
Nephropathy toxic	24.79	10.66	16	251969	27462	110309852
Withdrawal syndrome	24.78	10.66	21	251964	31359	110305955
Photophobia	24.65	10.66	14	251971	25757	110311557
Hypervolaemia	24.60	10.66	47	251938	49413	110287901
Haematoma	24.59	10.66	61	251924	58415	110278899
Drug level decreased	24.55	10.66	6	251979	18542	110318772
Dysuria	24.49	10.66	227	251758	60004	110277310
Blood cholesterol increased	24.47	10.66	286	251699	184499	110152815
Hair disorder	24.41	10.66	21	251964	1188	110336126
Device dislocation	24.09	10.66	22	251963	31682	110305632
Carcinoid tumour of the small bowel	23.91	10.66	14	251971	426	110336888
Burning sensation	23.84	10.66	252	251733	68960	110268354
Myoclonus	23.79	10.66	24	251961	32974	110304340
Akathisia	23.73	10.66	5	251980	17108	110320206
Disorientation	23.70	10.66	82	251903	70589	110266725
Lumbar spinal stenosis	23.60	10.66	48	251937	6385	110330929
Incorrect dose administered	23.50	10.66	139	251846	103502	110233812
Acidosis	23.40	10.66	11	251974	22520	110314794
Thyroid operation	23.29	10.66	11	251974	213	110337101
Angina pectoris	23.18	10.66	69	251916	62226	110275088
Neutrophil count decreased	23.18	10.66	396	251589	120545	110216769
Epstein-Barr virus infection	23.04	10.66	7	251978	18731	110318583
Pulmonary hypertension	22.92	10.66	58	251927	55162	110282152
Rales	22.87	10.66	14	251971	24725	110312589
Adnexa uteri mass	22.68	10.66	14	251971	470	110336844
Drug tolerance	22.68	10.66	5	251980	16580	110320734
Hepatitis cholestatic	22.64	10.66	6	251979	17560	110319754
Gastroenteritis radiation	22.63	10.66	17	251968	791	110336523
Female genital tract fistula	22.55	10.66	5	251980	16514	110320800
Nephrocalcinosis	22.35	10.66	24	251961	1790	110335524
Oroantral fistula	22.31	10.66	13	251972	392	110336922
Peripheral circulatory failure	22.30	10.66	24	251961	1795	110335519
Vaccination site reaction	22.26	10.66	11	251974	236	110337078
Pulmonary alveolar haemorrhage	22.25	10.66	9	251976	20141	110317173
Cognitive disorder	22.24	10.66	113	251872	87398	110249916
Bone marrow oedema	22.24	10.66	26	251959	2130	110335184
Aplastic anaemia	22.14	10.66	14	251971	24294	110313020
Prostate cancer recurrent	22.09	10.66	18	251967	944	110336370
Altered state of consciousness	22.05	10.66	63	251922	57563	110279751
Papillary thyroid cancer	22.05	10.66	30	251955	2864	110334450
Progressive multifocal leukoencephalopathy	21.88	10.66	15	251970	24941	110312373
Taste disorder	21.84	10.66	76	251909	65311	110272003
Gingival ulceration	21.83	10.66	20	251965	1230	110336084
Rash macular	21.78	10.66	157	251828	38529	110298785
Blood pressure abnormal	21.73	10.66	105	251880	22319	110314995
Giant cell arteritis	21.51	10.66	34	251951	3715	110333599
Proctitis	21.41	10.66	6	251979	16921	110320393
Cervical vertebral fracture	21.40	10.66	38	251947	4567	110332747
Quality of life decreased	21.36	10.66	76	251909	14093	110323221
Osteomalacia	21.34	10.66	22	251963	1565	110335749
Spinal disorder	21.31	10.66	67	251918	11661	110325653
Metastases to bone marrow	21.26	10.66	18	251967	996	110336318
Vascular device infection	21.10	10.66	84	251901	16428	110320886
Pathogen resistance	21.02	10.66	7	251978	17665	110319649
Pustular psoriasis	21.00	10.66	3	251982	13602	110323712
Pleurocutaneous fistula	20.92	10.66	7	251978	51	110337263
Heart rate increased	20.88	10.66	218	251767	143616	110193698
Vertebral lesion	20.80	10.66	15	251970	655	110336659
Clavicle fracture	20.74	10.66	41	251944	5343	110331971
Blood 1,25-dihydroxycholecalciferol decreased	20.69	10.66	7	251978	53	110337261
Chemotherapy	20.68	10.66	25	251960	2121	110335193
Actinomycosis	20.64	10.66	20	251965	1320	110335994
Pneumonia aspiration	20.58	10.66	105	251880	81128	110256186
Metastatic neoplasm	20.58	10.66	43	251942	5830	110331484
Infusion site pain	20.55	10.66	7	251978	17412	110319902
Spinal cord compression	20.54	10.66	50	251935	7502	110329812
Angina unstable	20.46	10.66	6	251979	16426	110320888
Blood cholesterol decreased	20.46	10.66	28	251957	2688	110334626
Drug dependence	20.40	10.66	53	251932	49967	110287347
Blood 25-hydroxycholecalciferol decreased	20.37	10.66	13	251972	463	110336851
Blood magnesium decreased	20.37	10.66	95	251890	19901	110317413
Tooth discolouration	20.36	10.66	20	251965	1343	110335971
Leukopenia	20.35	10.66	463	251522	148328	110188986
Serum procollagen type I N-terminal propeptide decreased	20.35	10.66	4	251981	0	110337314
Root canal infection	20.30	10.66	13	251972	466	110336848
Pulmonary oedema	20.26	10.66	140	251845	100519	110236795
Hallucination, visual	20.26	10.66	37	251948	39568	110297746
Fibula fracture	20.16	10.66	37	251948	4561	110332753
Aspiration	20.03	10.66	24	251961	30509	110306805
Haemorrhage intracranial	19.84	10.66	22	251963	28947	110308367
Spondylolisthesis	19.83	10.66	33	251952	3765	110333549
Electrocardiogram QRS complex prolonged	19.80	10.66	3	251982	13018	110324296
Finger deformity	19.67	10.66	28	251957	33064	110304250
Monocytosis	19.67	10.66	22	251963	1718	110335596
Bone fissure	19.65	10.66	14	251971	600	110336714
Renal injury	19.64	10.66	9	251976	18704	110318610
Bacteraemia	19.62	10.66	42	251943	42348	110294966
Intramedullary rod insertion	19.61	10.66	10	251975	230	110337084
Sinus bradycardia	19.53	10.66	23	251962	29460	110307854
Failure to anastomose	19.53	10.66	10	251975	232	110337082
Fibroblast growth factor 23 increased	19.52	10.66	6	251979	32	110337282
Bone metabolism biochemical marker increased	19.52	10.66	6	251979	32	110337282
Affect lability	19.51	10.66	9	251976	18628	110318686
Vertigo	19.49	10.66	292	251693	86578	110250736
Device fastener issue	19.48	10.66	8	251977	109	110337205
Flushing	19.48	10.66	149	251836	104587	110232727
Xeroderma	19.46	10.66	14	251971	609	110336705
Personality disorder	19.42	10.66	3	251982	12834	110324480
Temperature regulation disorder	19.40	10.66	3	251982	12823	110324491
Neurotoxicity	19.38	10.66	42	251943	42165	110295149
Sarcoma	19.20	10.66	17	251968	1000	110336314
Hepatic cytolysis	19.06	10.66	63	251922	54990	110282324
Hypovolaemia	19.04	10.66	13	251972	21661	110315653
CYP3A4 polymorphism	18.98	10.66	7	251978	70	110337244
Degenerative bone disease	18.97	10.66	9	251976	176	110337138
Adjusted calcium decreased	18.96	10.66	10	251975	247	110337067
Sense of oppression	18.91	10.66	21	251964	1627	110335687
Bone scan abnormal	18.89	10.66	10	251975	249	110337065
Fistula	18.88	10.66	77	251908	15222	110322092
Gait inability	18.87	10.66	209	251776	136167	110201147
Extraskeletal ossification	18.85	10.66	8	251977	119	110337195
Blood uric acid increased	18.79	10.66	13	251972	21516	110315798
Vertebral wedging	18.79	10.66	6	251979	37	110337277
Disturbance in attention	18.79	10.66	75	251910	61920	110275394
Pulmonary haemorrhage	18.75	10.66	7	251978	16449	110320865
Nephrolithiasis	18.72	10.66	232	251753	65980	110271334
Nasal congestion	18.67	10.66	139	251846	98143	110239171
Substance abuse	18.66	10.66	3	251982	12460	110324854
Tumour pain	18.55	10.66	28	251957	2939	110334375
Hepatic cyst	18.54	10.66	49	251936	7734	110329580
Macroenzyme creatine kinase	18.54	10.66	5	251980	15	110337299
Skin discolouration	18.53	10.66	182	251803	48864	110288450
Oligodipsia	18.52	10.66	6	251979	39	110337275
Decreased immune responsiveness	18.50	10.66	56	251929	9550	110327764
Pneumocystis jirovecii pneumonia	18.43	10.66	44	251941	42691	110294623
Prostatic specific antigen abnormal	18.38	10.66	14	251971	665	110336649
Vaginal discharge	18.20	10.66	9	251976	17899	110319415
Pain of skin	18.14	10.66	92	251893	19937	110317377
White blood cell disorder	18.13	10.66	32	251953	3827	110333487
Myocardial infarction	18.13	10.66	318	251667	191765	110145549
Bone neoplasm	18.10	10.66	16	251969	939	110336375
Thrombotic microangiopathy	17.99	10.66	24	251961	29125	110308189
Medial tibial stress syndrome	17.97	10.66	9	251976	199	110337115
Contusion	17.90	10.66	400	251585	232961	110104353
Invasive lobular breast carcinoma	17.89	10.66	15	251970	819	110336495
Subarachnoid haemorrhage	17.78	10.66	25	251960	29677	110307637
Radiation fibrosis - lung	17.77	10.66	7	251978	85	110337229
Acute generalised exanthematous pustulosis	17.72	10.66	14	251971	21650	110315664
Hypomagnesaemia	17.70	10.66	213	251772	60157	110277157
Hereditary optic atrophy	17.70	10.66	7	251978	86	110337228
Rash maculo-papular	17.66	10.66	98	251887	74124	110263190
Cardiac failure congestive	17.64	10.66	240	251745	150760	110186554
Parathyroid gland operation	17.63	10.66	5	251980	19	110337295
Therapeutic response shortened	17.61	10.66	25	251960	29558	110307756
Nail disorder	17.61	10.66	70	251915	57865	110279449
Hypercalcaemic nephropathy	17.58	10.66	4	251981	4	110337310
Onychalgia	17.57	10.66	17	251968	1120	110336194
Bronchospasm	17.57	10.66	26	251959	30213	110307101
Haemophagocytic lymphohistiocytosis	17.50	10.66	28	251957	31531	110305783
VIth nerve paresis	17.47	10.66	8	251977	144	110337170
Sensory loss	17.39	10.66	14	251971	21443	110315871
Osteocalcin decreased	17.34	10.66	6	251979	49	110337265
Metastases to neck	17.34	10.66	6	251979	49	110337265
Exposure to toxic agent	17.33	10.66	4	251981	12854	110324460
Immune effector cell-associated neurotoxicity syndrome	17.33	10.66	6	251979	14776	110322538
Blood pressure increased	17.31	10.66	452	251533	257921	110079393
Atelectasis	17.30	10.66	36	251949	36676	110300638
Respiratory acidosis	17.30	10.66	5	251980	13821	110323493
Caesarean section	17.28	10.66	5	251980	13812	110323502
Pneumonia fungal	17.28	10.66	6	251979	14748	110322566
Anger	17.24	10.66	11	251974	18996	110318318
Anuria	17.21	10.66	18	251967	24323	110312991
Prostatic specific antigen decreased	17.20	10.66	7	251978	93	110337221
Anaphylactic shock	17.16	10.66	60	251925	51486	110285828
Immunosuppressant drug level increased	17.16	10.66	3	251982	11721	110325593
Breast pain	17.14	10.66	56	251929	9944	110327370
Hyperammonaemia	17.12	10.66	5	251980	13727	110323587
Respiratory disorder	17.12	10.66	94	251891	71288	110266026
Drug level below therapeutic	17.05	10.66	3	251982	11670	110325644
Invasive ductal breast carcinoma	17.02	10.66	43	251942	6603	110330711
Encephalitis	16.95	10.66	11	251974	18828	110318486
Carbohydrate antigen 15-3	16.81	10.66	7	251978	99	110337215
Ulcer haemorrhage	16.75	10.66	16	251969	22555	110314759
Creatinine renal clearance decreased	16.74	10.66	15	251970	21800	110315514
Triple negative breast cancer	16.72	10.66	12	251973	520	110336794
Nail avulsion	16.70	10.66	8	251977	160	110337154
Dental paraesthesia	16.69	10.66	4	251981	6	110337308
Pulpless tooth	16.69	10.66	4	251981	6	110337308
Metastases to pleura	16.66	10.66	22	251963	2041	110335273
Brain injury	16.63	10.66	5	251980	13471	110323843
Osteosarcoma	16.61	10.66	11	251974	418	110336896
Skin disorder	16.58	10.66	160	251825	42753	110294561
Toxic encephalopathy	16.47	10.66	7	251978	15207	110322107
Atrioventricular block complete	16.40	10.66	13	251972	20069	110317245
Oral mucosal erythema	16.38	10.66	23	251962	2261	110335053
Ovarian cancer	16.36	10.66	33	251952	4363	110332951
Atrophic vulvovaginitis	16.34	10.66	18	251967	1382	110335932
Catatonia	16.30	10.66	3	251982	11297	110326017
Gingival discolouration	16.24	10.66	9	251976	246	110337068
Oesophageal ulcer haemorrhage	16.18	10.66	15	251970	937	110336377
Diffuse large B-cell lymphoma	16.14	10.66	8	251977	15890	110321424
Hypercalcaemia of malignancy	16.13	10.66	12	251973	550	110336764
Dental alveolar anomaly	16.06	10.66	5	251980	28	110337286
Mucosal inflammation	16.03	10.66	308	251677	95833	110241481
Respiratory symptom	15.98	10.66	7	251978	14938	110322376
Stress	15.98	10.66	158	251827	105190	110232124
Troponin increased	15.96	10.66	27	251958	29739	110307575
Haematuria	15.95	10.66	117	251868	82888	110254426
Affective disorder	15.85	10.66	59	251926	11182	110326132
Enchondromatosis	15.81	10.66	7	251978	116	110337198
Eastern Cooperative Oncology Group performance status worsened	15.77	10.66	26	251959	2943	110334371
Ovarian disorder	15.61	10.66	12	251973	578	110336736
Upper respiratory tract infection	15.61	10.66	208	251777	131120	110206194
Panniculitis	15.58	10.66	8	251977	15574	110321740
Joint destruction	15.58	10.66	3	251982	10940	110326374
Metastases to soft tissue	15.57	10.66	13	251972	706	110336608
Venous thrombosis limb	15.56	10.66	36	251949	5229	110332085
Immunoglobulins decreased	15.52	10.66	23	251962	2376	110334938
Heavy menstrual bleeding	15.50	10.66	9	251976	16356	110320958
Cardiac murmur	15.49	10.66	20	251965	24608	110312706
Impaired quality of life	15.39	10.66	28	251957	29989	110307325
Haemorrhage	15.36	10.66	162	251823	106530	110230784
Acute coronary syndrome	15.34	10.66	18	251967	23094	110314220
Oliguria	15.34	10.66	12	251973	18645	110318669
Arthropod infestation	15.26	10.66	3	251982	0	110337314
Diabetic endorgan damage	15.26	10.66	3	251982	0	110337314
Periodontal operation	15.26	10.66	3	251982	0	110337314
Refusal of treatment by patient	15.24	10.66	52	251933	9442	110327872
Injection site erythema	15.24	10.66	139	251846	94037	110243277
Macule	15.19	10.66	29	251956	3684	110333630
Allergy to plants	15.17	10.66	14	251971	869	110336445
Ulcer	15.16	10.66	49	251936	43067	110294247
Respiratory syncytial virus infection	15.15	10.66	7	251978	14477	110322837
Skin necrosis	15.11	10.66	16	251969	21496	110315818
Myasthenia gravis	15.10	10.66	16	251969	21495	110315819
Ear disorder	15.08	10.66	34	251951	4855	110332459
Mouth ulceration	15.07	10.66	172	251813	47966	110289348
Surgery	15.02	10.66	152	251833	41131	110296183
Hypoacusis	15	10.66	134	251851	35057	110302257
Blood creatinine abnormal	14.96	10.66	38	251947	5854	110331460
Intervertebral disc degeneration	14.95	10.66	81	251904	18004	110319310
Sternal fracture	14.94	10.66	27	251958	3289	110334025
Basal cell carcinoma	14.86	10.66	53	251932	45217	110292097
Ear infection	14.83	10.66	83	251902	62649	110274665
Extradural neoplasm	14.83	10.66	4	251981	12	110337302
Device malfunction	14.82	10.66	22	251963	25536	110311778
Catheter site injury	14.77	10.66	9	251976	295	110337019
Gingival atrophy	14.73	10.66	6	251979	80	110337234
Tumour lysis syndrome	14.69	10.66	30	251955	30771	110306543
Dental cyst	14.65	10.66	5	251980	39	110337275
Blood glucose increased	14.62	10.66	213	251772	132283	110205031
Chronic leukaemia	14.59	10.66	4	251981	13	110337301
Bacterial sepsis	14.55	10.66	3	251982	10423	110326891
Myocardial ischaemia	14.50	10.66	24	251961	26660	110310654
Enterococcal infection	14.47	10.66	15	251970	20351	110316963
Metastases to the mediastinum	14.46	10.66	13	251972	780	110336534
Nasal polyps	14.41	10.66	6	251979	13194	110324120
Seronegative arthritis	14.36	10.66	6	251979	13171	110324143
Breast mass	14.33	10.66	46	251939	8095	110329219
Tooth deposit	14.27	10.66	9	251976	314	110337000
Hepatocellular injury	14.27	10.66	63	251922	50579	110286735
Paraesthesia oral	14.24	10.66	128	251857	33543	110303771
Deafness	14.24	10.66	107	251878	26602	110310712
Polyneuropathy	14.22	10.66	123	251862	31889	110305425
Ankylosing spondylitis	14.21	10.66	9	251976	15603	110321711
Appendicitis	14.20	10.66	27	251958	28437	110308877
Wrong product administered	14.20	10.66	56	251929	10904	110326410
Metastases to chest wall	14.18	10.66	12	251973	664	110336650
Dyspepsia	14.17	10.66	329	251656	190636	110146678
Melaena	14.15	10.66	95	251890	68662	110268652
Retinal operation	14.15	10.66	4	251981	15	110337299
Skin sensitisation	14.13	10.66	15	251970	1104	110336210
Carbohydrate antigen 19-9 increased	14.04	10.66	11	251974	545	110336769
Hypercapnia	14.03	10.66	4	251981	11155	110326159
Spinal laminectomy	13.98	10.66	13	251972	815	110336499
Carcinoembryonic antigen	13.97	10.66	6	251979	92	110337222
Pulmonary tumour thrombotic microangiopathy	13.97	10.66	7	251978	155	110337159
Hypoaesthesia teeth	13.93	10.66	5	251980	46	110337268
Malpositioned teeth	13.93	10.66	5	251980	46	110337268
COVID-19 pneumonia	13.92	10.66	41	251944	37102	110300212
Tuberculosis	13.90	10.66	12	251973	17762	110319552
Metastases to eye	13.90	10.66	9	251976	329	110336985
Jaundice cholestatic	13.88	10.66	8	251977	14600	110322714
Pelvi-ureteric obstruction	13.87	10.66	9	251976	330	110336984
Hepatomegaly	13.87	10.66	17	251968	21397	110315917
Food allergy	13.83	10.66	15	251970	19933	110317381
Haemodialysis	13.82	10.66	12	251973	17707	110319607
High turnover osteopathy	13.80	10.66	6	251979	95	110337219
Pleural effusion	13.79	10.66	515	251470	177194	110160120
Escherichia urinary tract infection	13.78	10.66	73	251912	16089	110321225
Metastases to vagina	13.75	10.66	4	251981	17	110337297
Adenosquamous cell lung cancer	13.74	10.66	5	251980	48	110337266
Osteoporosis postmenopausal	13.74	10.66	5	251980	48	110337266
Arteriosclerosis	13.71	10.66	22	251963	24745	110312569
Pericoronitis	13.69	10.66	7	251978	162	110337152
Presyncope	13.66	10.66	61	251924	48826	110288488
Gas gangrene	13.66	10.66	9	251976	339	110336975
Arthritis	13.57	10.66	488	251497	167098	110170216
Blood phosphorus abnormal	13.56	10.66	9	251976	343	110336971
Tardive dyskinesia	13.54	10.66	7	251978	13572	110323742
Tricuspid valve incompetence	13.41	10.66	21	251964	23852	110313462
Fracture nonunion	13.39	10.66	17	251968	1517	110335797
Psychotic disorder	13.39	10.66	65	251920	50872	110286442
Constipation	13.37	10.66	967	251018	356819	109980495
Adjustment disorder	13.33	10.66	4	251981	10791	110326523
Mucosal pain	13.30	10.66	5	251980	53	110337261
Sudden death	13.20	10.66	22	251963	24373	110312941
Nail discolouration	13.19	10.66	27	251958	3608	110333706
Skeletal dysplasia	13.19	10.66	3	251982	3	110337311
Follicular dendritic cell sarcoma	13.19	10.66	3	251982	3	110337311
Bone infarction	13.08	10.66	11	251974	603	110336711
BRCA2 gene mutation	13.00	10.66	6	251979	110	110337204
Bone fragmentation	12.98	10.66	12	251973	747	110336567
Inappropriate antidiuretic hormone secretion	12.96	10.66	37	251948	33814	110303500
Deafness neurosensory	12.95	10.66	3	251982	9616	110327698
Bladder disorder	12.92	10.66	55	251930	11082	110326232
Neurological symptom	12.88	10.66	10	251975	15598	110321716
Nail bed tenderness	12.85	10.66	9	251976	375	110336939
Urine calcium increased	12.85	10.66	6	251979	113	110337201
Forced expiratory volume decreased	12.83	10.66	7	251978	13169	110324145
Blood phosphorus increased	12.82	10.66	11	251974	16329	110320985
Eye inflammation	12.82	10.66	48	251937	9123	110328191
Transfusion-related circulatory overload	12.81	10.66	13	251972	908	110336406
Metastases to adrenals	12.80	10.66	17	251968	1586	110335728
Electrocardiogram QT interval	12.74	10.66	8	251977	277	110337037
Cementoplasty	12.73	10.66	3	251982	4	110337310
Otitis externa bacterial	12.73	10.66	3	251982	4	110337310
Gingival cyst	12.73	10.66	3	251982	4	110337310
Hypopnoea	12.70	10.66	5	251980	11375	110325939
Lip exfoliation	12.70	10.66	12	251973	768	110336546
Sputum discoloured	12.67	10.66	28	251957	27917	110309397
Demyelination	12.58	10.66	3	251982	9426	110327888
Naevus haemorrhage	12.57	10.66	6	251979	119	110337195
Atrial fibrillation	12.55	10.66	413	251572	229229	110108085
Colonoscopy	12.55	10.66	20	251965	2200	110335114
Wisdom teeth removal	12.46	10.66	12	251973	786	110336528
Osteopenia	12.43	10.66	90	251895	22119	110315195
Adrenal insufficiency	12.39	10.66	52	251933	42338	110294976
Open fracture	12.38	10.66	10	251975	518	110336796
Chondropathy	12.37	10.66	23	251962	2864	110334450
Eosinophil count increased	12.34	10.66	18	251967	21040	110316274
Bone giant cell tumour benign	12.33	10.66	3	251982	5	110337309
Phosphaturic mesenchymal tumour	12.33	10.66	3	251982	5	110337309
Myelodysplastic syndrome	12.23	10.66	44	251941	37440	110299874
Exposure to SARS-CoV-2	12.19	10.66	23	251962	2896	110334418
Staphylococcal bacteraemia	12.19	10.66	12	251973	16676	110320638
Treatment noncompliance	12.13	10.66	107	251878	72883	110264431
Hyperbilirubinaemia	12.13	10.66	33	251952	30638	110306676
Nail growth abnormal	12.10	10.66	10	251975	535	110336779
Methaemoglobinaemia	12.07	10.66	3	251982	9165	110328149
Thyroid disorder	12.06	10.66	73	251912	16896	110320418
Alopecia	12.00	10.66	976	251009	363777	109973537
Vascular fragility	11.99	10.66	7	251978	212	110337102
Hydrocalyx	11.98	10.66	3	251982	6	110337308
Hypocalcaemic seizure	11.97	10.66	6	251979	133	110337181
Periumbilical abscess	11.94	10.66	8	251977	310	110337004
Device loosening	11.92	10.66	12	251973	830	110336484
Injury associated with device	11.88	10.66	29	251956	4360	110332954
Sinus congestion	11.87	10.66	33	251952	30426	110306888
Malocclusion	11.87	10.66	7	251978	216	110337098
Asphyxia	11.87	10.66	9	251976	14206	110323108
Blood pressure fluctuation	11.86	10.66	111	251874	74713	110262601
Purulence	11.86	10.66	20	251965	2307	110335007
Deformity thorax	11.85	10.66	4	251981	30	110337284
Tachyphylaxis	11.85	10.66	9	251976	426	110336888
Productive cough	11.84	10.66	186	251799	114119	110223195
Spinal column injury	11.83	10.66	20	251965	2311	110335003
Mood altered	11.82	10.66	19	251966	21356	110315958
Laryngitis viral	11.80	10.66	5	251980	74	110337240
Metastases to pelvis	11.80	10.66	12	251973	840	110336474
Alcohol poisoning	11.78	10.66	3	251982	9017	110328297
Calcium deficiency	11.77	10.66	14	251971	1168	110336146
Bradyphrenia	11.76	10.66	6	251979	11722	110325592
Immunodeficiency	11.76	10.66	47	251938	38791	110298523
Autoimmune lung disease	11.75	10.66	7	251978	220	110337094
Knee operation	11.75	10.66	39	251946	6983	110330331
Metastases to pituitary gland	11.74	10.66	4	251981	31	110337283
Serum procollagen type I N-terminal propeptide increased	11.74	10.66	4	251981	31	110337283
Osteoradionecrosis	11.73	10.66	6	251979	139	110337175
Decreased appetite	11.70	10.66	1247	250738	474599	109862715
Blood culture positive	11.70	10.66	3	251982	8973	110328341
Hepatic necrosis	11.68	10.66	4	251981	9918	110327396
Gangrene	11.65	10.66	12	251973	16329	110320985
Lower gastrointestinal haemorrhage	11.64	10.66	15	251970	18471	110318843
Potentiating drug interaction	11.61	10.66	6	251979	11637	110325677
Respiratory tract congestion	11.61	10.66	34	251951	30823	110306491
Adjusted calcium increased	11.56	10.66	5	251980	78	110337236
Haemangioma	11.53	10.66	22	251963	2794	110334520
Avulsion fracture	11.52	10.66	8	251977	329	110336985
Blood glucose decreased	11.46	10.66	32	251953	29456	110307858
Eosinophilic granulomatosis with polyangiitis	11.43	10.66	5	251980	10681	110326633
Complication of device insertion	11.43	10.66	3	251982	8835	110328479
Bone metabolism disorder	11.41	10.66	10	251975	580	110336734
Euphoric mood	11.41	10.66	3	251982	8824	110328490
Catheter site bruise	11.40	10.66	10	251975	581	110336733
Metastases to uterus	11.34	10.66	5	251980	82	110337232
Fracture delayed union	11.32	10.66	19	251966	2182	110335132
Mandibular mass	11.31	10.66	7	251978	236	110337078
Gingival erosion	11.31	10.66	6	251979	150	110337164
Pleural disorder	11.31	10.66	13	251972	1046	110336268
Gastrointestinal bacterial infection	11.26	10.66	15	251970	1403	110335911
Atrial flutter	11.26	10.66	24	251961	24238	110313076
Hypovolaemic shock	11.22	10.66	10	251975	14573	110322741
Hypocalciuria	11.22	10.66	4	251981	36	110337278
Blood creatinine increased	11.20	10.66	324	251661	182565	110154749
Triple positive breast cancer	11.12	10.66	3	251982	9	110337305
Injected limb mobility decreased	11.12	10.66	4	251981	37	110337277
Nasopharyngeal cancer metastatic	11.12	10.66	3	251982	9	110337305
Spinal stenosis	11.11	10.66	78	251907	18978	110318336
Subdural haematoma	11.11	10.66	44	251941	36410	110300904
Underdose	11.08	10.66	92	251893	63462	110273852
Blood bilirubin increased	11.08	10.66	115	251870	75857	110261457
Bile duct stenosis	11.07	10.66	21	251964	2655	110334659
End stage renal disease	11.04	10.66	20	251965	21453	110315861
Plantar fasciitis	11.04	10.66	31	251954	5070	110332244
Abdominal distension	11.03	10.66	309	251676	174794	110162520
Hemiplegia	11.03	10.66	22	251963	22760	110314554
Bone operation	11.02	10.66	8	251977	353	110336961
Complement factor C4 decreased	10.98	10.66	8	251977	355	110336959
Sickle cell anaemia with crisis	10.98	10.66	4	251981	9541	110327773
Injection site pruritus	10.96	10.66	70	251915	51188	110286126
Facial pain	10.91	10.66	66	251919	15273	110322041
Cholecystitis chronic	10.89	10.66	4	251981	9496	110327818
Vaginal lesion	10.88	10.66	8	251977	360	110336954
Metastases to penis	10.88	10.66	3	251982	10	110337304
Klebsiella infection	10.87	10.66	18	251967	19991	110317323
Adenoid cystic carcinoma	10.85	10.66	4	251981	40	110337274
Sexual dysfunction	10.83	10.66	3	251982	8527	110328787
Lymphocele	10.78	10.66	17	251968	1854	110335460
Muscle atrophy	10.71	10.66	59	251926	13195	110324119
Oral mucosal discolouration	10.71	10.66	8	251977	369	110336945
Back disorder	10.70	10.66	83	251902	20839	110316475
Dermo-hypodermitis	10.70	10.66	15	251970	1473	110335841

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	M05BX04	MUSCULO-SKELETAL SYSTEM DRUGS FOR TREATMENT OF BONE DISEASES DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION Other drugs affecting bone structure and mineralization
MeSH PA	D050071	Bone Density Conservation Agents
FDA MoA	N0000187054	RANK Ligand Blocking Activity
FDA EPC	N0000187055	RANK Ligand Inhibitor
CHEBI has role	CHEBI:35526	hypoglycemic agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:35842	antirheumatic drug
CHEBI has role	CHEBI:35845	gout suppressant
CHEBI has role	CHEBI:50646	bone density conservation agent
CHEBI has role	CHEBI:50779	appetite enhancer
CHEBI has role	CHEBI:231911	renoprotective agent

Related Drugs by ATC class:

M05BX Other drugs affecting bone structure and mineralization 8 drugs

aluminium chlorohydrateburosumabcolecalciferolipriflavonemenatetrenoneromosozumabstrontium ranelatevosoritide

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Drug-induced osteoporosis	indication	14651005
Osteoporosis	indication	64859006	DOID:11476
Postmenopausal osteoporosis	indication	102447009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Tumor necrosis factor ligand superfamily member 11	Cytokine	O14788	TNF11_HUMAN	ANTIBODY BINDING				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
D03684	KEGG_DRUG
4030131	VUID
N0000181718	NUI
4030131	VANDF
CHEBI:749681	CHEBI
CHEMBL1237023	ChEMBL_ID
6886	IUPHAR_LIGAND_ID
DB06643	DRUGBANK_ID
993449	RXNORM
173191	MMSL
27218	MMSL
d07640	MMSL
013441	NDDF
446321003	SNOMEDCT_US
446457007	SNOMEDCT_US
C1690432	UMLSCUI
D000069448	MESH_DESCRIPTOR_UI
8653	INN_ID
4EQZ6YO2HI	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
ENOBY	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9165	INJECTION	60 mg	SUBCUTANEOUS	BLA	31 sections
XTRENBO	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9166	INJECTION	120 mg	SUBCUTANEOUS	BLA	28 sections
Prolia	HUMAN PRESCRIPTION DRUG LABEL	1	55513-710	INJECTION	60 mg	SUBCUTANEOUS	BLA	33 sections
XGEVA	HUMAN PRESCRIPTION DRUG LABEL	1	55513-730	INJECTION	120 mg	SUBCUTANEOUS	BLA	30 sections
WYOST	HUMAN PRESCRIPTION DRUG LABEL	1	61314-228	INJECTION	120 mg	SUBCUTANEOUS	BLA	27 sections
WYOST	HUMAN PRESCRIPTION DRUG LABEL	1	61314-228	INJECTION	120 mg	SUBCUTANEOUS	BLA	27 sections
JUBBONTI	HUMAN PRESCRIPTION DRUG LABEL	1	61314-240	INJECTION	60 mg	SUBCUTANEOUS	BLA	30 sections
JUBBONTI	HUMAN PRESCRIPTION DRUG LABEL	1	61314-240	INJECTION	60 mg	SUBCUTANEOUS	BLA	30 sections
CONEXXENCE	HUMAN PRESCRIPTION DRUG LABEL	1	65219-668	INJECTION	60 mg	SUBCUTANEOUS	BLA	33 sections
BOMYNTRA	HUMAN PRESCRIPTION DRUG LABEL	1	65219-670	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
BOMYNTRA	HUMAN PRESCRIPTION DRUG LABEL	1	65219-672	INJECTION	70 mg	SUBCUTANEOUS	BLA	30 sections
OSVYRTI	HUMAN PRESCRIPTION DRUG LABEL	1	69448-021	INJECTION	60 mg	SUBCUTANEOUS	BLA	32 sections
JUBEREQ	HUMAN PRESCRIPTION DRUG LABEL	1	69448-022	INJECTION	70 mg	SUBCUTANEOUS	BLA	27 sections
Oziltus	HUMAN PRESCRIPTION DRUG LABEL	1	70121-2701	INJECTION, SOLUTION	70 mg	SUBCUTANEOUS	BLA	27 sections
Boncresa	HUMAN PRESCRIPTION DRUG LABEL	1	70121-2702	INJECTION, SOLUTION	60 mg	SUBCUTANEOUS	BLA	29 sections
Stoboclo	HUMAN PRESCRIPTION DRUG LABEL	1	72606-037	INJECTION	60 mg	SUBCUTANEOUS	BLA	33 sections
Stoboclo	HUMAN PRESCRIPTION DRUG LABEL	1	72606-037	INJECTION	60 mg	SUBCUTANEOUS	BLA	33 sections
Osenvelt	HUMAN PRESCRIPTION DRUG LABEL	1	72606-038	INJECTION	120 mg	SUBCUTANEOUS	BLA	31 sections
Denosumab-BMWO	HUMAN PRESCRIPTION DRUG LABEL	1	72606-058	INJECTION	60 mg	SUBCUTANEOUS	BLA	33 sections
Denosumab-BMWO	HUMAN PRESCRIPTION DRUG LABEL	1	72606-058	INJECTION	60 mg	SUBCUTANEOUS	BLA	33 sections
Denosumab-BMWO	HUMAN PRESCRIPTION DRUG LABEL	1	72606-059	INJECTION	120 mg	SUBCUTANEOUS	BLA	31 sections
BILDYOS	HUMAN PRESCRIPTION DRUG LABEL	1	78206-193	INJECTION, SOLUTION	60 mg	SUBCUTANEOUS	BLA	33 sections
Bilprevda	HUMAN PRESCRIPTION DRUG LABEL	1	78206-195	INJECTION, SOLUTION	120 mg	SUBCUTANEOUS	BLA	31 sections
BOSAYA	HUMAN PRESCRIPTION DRUG LABEL	1	83257-029	INJECTION	60 mg	SUBCUTANEOUS	BLA	28 sections
AUKELSO	HUMAN PRESCRIPTION DRUG LABEL	1	83257-030	INJECTION	120 mg	SUBCUTANEOUS	BLA	28 sections
OSPOMYV	HUMAN PRESCRIPTION DRUG LABEL	1	83457-012	INJECTION, SOLUTION	60 mg	SUBCUTANEOUS	BLA	32 sections