denosumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
human origin 4965 615258-40-7

Description:

MoleculeDescription

Synonyms:

  • denosumab
  • prolia
  • AMG 162
  • AMG162
A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
0.33 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 26, 2010 EMA Amgen Europe B.V.
June 1, 2010 FDA AMGEN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 48997.36 11.45 27249 174636 447177 49956062
Osteonecrosis of jaw 9928.87 11.45 4014 197871 28512 50374727
Death 5539.68 11.45 6623 195262 318756 50084483
Spinal fracture 2247.79 11.45 1142 200743 14431 50388808
Bone pain 1941.21 11.45 1565 200320 45664 50357575
Tooth disorder 1774.93 11.45 1141 200744 23087 50380152
Hypocalcaemia 1721.80 11.45 1163 200722 25653 50377586
Pain in jaw 1386.16 11.45 1181 200704 37247 50365992
Drug ineffective 1365.04 11.45 795 201090 818538 49584701
Atypical femur fracture 1327.29 11.45 557 201328 4359 50398880
Tooth extraction 1235.38 11.45 640 201245 8435 50394804
Back pain 1151.40 11.45 2639 199246 217391 50185848
Pain in extremity 1043.26 11.45 2905 198980 269960 50133279
Myalgia 937.46 11.45 1735 200150 122584 50280655
Bone density abnormal 772.04 11.45 330 201555 2715 50400524
Occupational exposure to product 767.79 11.45 284 201601 1516 50401723
Tooth fracture 717.50 11.45 459 201426 9192 50394047
Bone density decreased 704.90 11.45 478 201407 10597 50392642
Accidental exposure to product 688.41 11.45 637 201248 22420 50380819
Fracture 682.78 11.45 554 201331 16279 50386960
Rebound effect 654.74 11.45 298 201587 2891 50400348
Thoracic vertebral fracture 650.17 11.45 320 201565 3753 50399486
Arthralgia 642.62 11.45 3441 198444 435261 49967978
Toothache 579.92 11.45 505 201380 16389 50386850
Toxicity to various agents 575.66 11.45 82 201803 212417 50190822
Lumbar vertebral fracture 565.36 11.45 303 201582 4294 50398945
Maternal exposure during pregnancy 516.65 11.45 30 201855 159748 50243491
Metastases to bone 511.85 11.45 484 201401 17511 50385728
Completed suicide 508.34 11.45 3 201882 131886 50271353
Spinal compression fracture 484.89 11.45 403 201482 12253 50390986
Dental implantation 482.58 11.45 153 201732 459 50402780
Blood parathyroid hormone increased 475.83 11.45 231 201654 2623 50400616
Jaw disorder 474.83 11.45 277 201608 4666 50398573
Exposed bone in jaw 473.97 11.45 229 201656 2571 50400668
Dental care 468.38 11.45 166 201719 766 50402473
Exposure during pregnancy 460.18 11.45 4 201881 121011 50282228
Groin pain 457.42 11.45 337 201548 8554 50394685
Drug intolerance 447.10 11.45 158 201727 218946 50184293
Tooth loss 442.70 11.45 287 201598 5883 50397356
Pemphigus 435.16 11.45 9 201876 120157 50283082
Hip fracture 428.41 11.45 523 201362 25408 50377831
Drug interaction 424.64 11.45 134 201751 199487 50203752
Infusion related reaction 424.40 11.45 81 201804 169476 50233763
Femur fracture 423.53 11.45 628 201257 36836 50366403
Contraindicated product administered 413.88 11.45 53 201832 148905 50254334
Treatment failure 399.77 11.45 42 201843 137595 50265644
Synovitis 398.10 11.45 24 201861 123841 50279398
Pathological fracture 392.55 11.45 290 201595 7392 50395847
Condition aggravated 382.54 11.45 373 201512 296685 50106554
Musculoskeletal pain 378.55 11.45 868 201017 71309 50331930
Systemic lupus erythematosus 360.86 11.45 63 201822 140559 50262680
Terminal state 346.41 11.45 169 201716 1941 50401298
Drug hypersensitivity 343.43 11.45 298 201587 250712 50152527
Bone loss 342.33 11.45 181 201704 2491 50400748
Product use issue 327.44 11.45 95 201790 149380 50253859
Breast cancer metastatic 314.44 11.45 289 201596 10075 50393164
Loose tooth 309.19 11.45 181 201704 3069 50400170
Acute kidney injury 298.48 11.45 282 201603 227776 50175463
Joint swelling 285.48 11.45 335 201550 244951 50158288
Glossodynia 285.30 11.45 57 201828 115512 50287727
Hypotension 284.47 11.45 312 201573 235157 50168082
Exostosis of jaw 282.49 11.45 124 201761 1095 50402144
Therapeutic product effect decreased 279.22 11.45 97 201788 135953 50267286
Hepatic enzyme increased 275.06 11.45 102 201783 137278 50265961
Incorrect route of product administration 274.09 11.45 355 201530 18311 50384928
Vomiting 272.48 11.45 936 200949 459822 49943417
Hospitalisation 257.93 11.45 723 201162 67214 50336025
Blood calcium decreased 255.68 11.45 362 201523 20344 50382895
Hand deformity 254.59 11.45 46 201839 100153 50303086
Dental caries 249.78 11.45 249 201636 9618 50393621
Osteomyelitis 243 11.45 368 201517 21985 50381254
Overdose 240.34 11.45 52 201833 99675 50303564
Metastases to liver 240.19 11.45 346 201539 19758 50383481
Intentional overdose 233.24 11.45 3 201882 62501 50340738
Product use in unapproved indication 228.46 11.45 88 201797 115731 50287508
Somnolence 228.01 11.45 171 201714 154814 50248425
Atypical fracture 224.56 11.45 86 201799 513 50402726
Drug abuse 222.76 11.45 3 201882 59843 50343396
Abdominal discomfort 221.76 11.45 364 201521 231277 50171962
Pericarditis 216.05 11.45 29 201856 78660 50324579
Foot fracture 214.49 11.45 328 201557 19763 50383476
Wound 210.97 11.45 79 201806 105715 50297524
Neoplasm progression 210.57 11.45 400 201485 28757 50374482
Rheumatoid arthritis 209.46 11.45 302 201583 202248 50200991
Eczema 204.48 11.45 343 201542 22359 50380880
Investigation 204.13 11.45 107 201778 1445 50401794
Dyspnoea 204.02 11.45 1315 200570 546293 49856946
Mobility decreased 202.19 11.45 740 201145 79208 50324031
Blood calcium increased 201.33 11.45 198 201687 7521 50395718
Confusional state 199.44 11.45 270 201615 185658 50217581
Product storage error 197.73 11.45 244 201641 11980 50391259
Bone disorder 197.17 11.45 304 201581 18448 50384791
Endodontic procedure 190.30 11.45 125 201760 2621 50400618
Swelling 189.10 11.45 319 201566 200553 50202686
Muscle spasms 188.05 11.45 993 200892 124560 50278679
Compression fracture 185.35 11.45 167 201718 5670 50397569
Nausea 184.98 11.45 1863 200022 703535 49699704
Jaw operation 179.63 11.45 79 201806 701 50402538
Rheumatoid factor positive 179.38 11.45 4 201881 49855 50353384
Multiple fractures 176.95 11.45 172 201713 6439 50396800
Weight increased 171.88 11.45 341 201544 201550 50201689
Gingival pain 169.71 11.45 161 201724 5845 50397394
Headache 167.04 11.45 1260 200625 505275 49897964
Temporomandibular joint syndrome 166.13 11.45 127 201758 3412 50399827
Helicobacter infection 164.69 11.45 8 201877 49694 50353545
Tooth abscess 163.46 11.45 228 201657 12632 50390607
Seizure 160.89 11.45 140 201745 117734 50285505
Suicide attempt 160.34 11.45 12 201873 51720 50351519
Blood calcium abnormal 157.62 11.45 80 201805 1006 50402233
Gingival disorder 157.05 11.45 118 201767 3087 50400152
Duodenal ulcer perforation 155.57 11.45 6 201879 45605 50357634
Malignant neoplasm progression 154.43 11.45 609 201276 67515 50335724
Bradycardia 154.37 11.45 34 201851 64392 50338847
Cardiac arrest 153.01 11.45 71 201814 83580 50319659
Osteonecrosis 150.49 11.45 299 201586 22218 50381021
Tooth infection 148.67 11.45 229 201656 13883 50389356
Intentional product use issue 145.85 11.45 62 201823 76856 50326383
Wrist fracture 145.02 11.45 203 201682 11284 50391955
Pyrexia 144.33 11.45 907 200978 379296 50023943
Artificial crown procedure 143.52 11.45 50 201835 217 50403022
Dental operation 142.74 11.45 75 201810 1018 50402221
Pneumonia 142.45 11.45 905 200980 377496 50025743
Abortion spontaneous 137.52 11.45 7 201878 41765 50361474
Pelvic fracture 135.74 11.45 197 201688 11323 50391916
Gingivitis 135.26 11.45 156 201729 7128 50396111
Spinal pain 133.55 11.45 189 201696 10614 50392625
Cystitis 133.07 11.45 436 201449 44128 50359111
Tetany 132.76 11.45 82 201803 1539 50401700
Coma 132.33 11.45 32 201853 56847 50346392
Hyperaesthesia teeth 132.16 11.45 80 201805 1446 50401793
Gingival recession 130.88 11.45 75 201810 1219 50402020
Hypersensitivity 130.21 11.45 432 201453 214729 50188510
Sinusitis 129.44 11.45 307 201578 170251 50232988
Abdominal pain 128.54 11.45 496 201389 235732 50167507
Tachycardia 128.42 11.45 125 201760 99638 50303601
Bedridden 128.00 11.45 172 201713 9195 50394044
Suicidal ideation 127.21 11.45 32 201853 55353 50347886
Dental restoration failure 125.23 11.45 56 201829 519 50402720
Cardio-respiratory arrest 124.05 11.45 31 201854 53861 50349378
Depressed level of consciousness 123.29 11.45 28 201857 51925 50351314
Folliculitis 121.84 11.45 9 201876 39216 50364023
Oxygen saturation decreased 120.89 11.45 71 201814 73177 50330062
Muscle injury 119.74 11.45 7 201878 37104 50366135
Stress fracture 118.95 11.45 142 201743 6733 50396506
Hyponatraemia 118.56 11.45 125 201760 96014 50307225
Abscess jaw 117.11 11.45 71 201814 1287 50401952
Lower limb fracture 116.17 11.45 206 201679 14040 50389199
Lactic acidosis 115.09 11.45 4 201881 33351 50369888
Inappropriate schedule of product administration 112.90 11.45 576 201309 71255 50331984
Breast cancer 110.91 11.45 400 201485 42490 50360749
Respiratory failure 110.83 11.45 120 201765 91061 50312178
Gingival swelling 109.65 11.45 103 201782 3692 50399547
Febrile neutropenia 109.60 11.45 137 201748 97530 50305709
Rib fracture 109.45 11.45 239 201646 18982 50384257
Multiple sclerosis relapse 108.49 11.45 20 201865 42944 50360295
Lower respiratory tract infection 108.45 11.45 132 201753 95069 50308170
Metastases to lung 108.00 11.45 173 201712 10847 50392392
Hypoglycaemia 105.13 11.45 41 201844 53540 50349699
Periodontitis 103.79 11.45 91 201794 2978 50400261
Agitation 102.86 11.45 42 201843 53342 50349897
Psoriatic arthropathy 100.88 11.45 31 201854 47001 50356238
Musculoskeletal discomfort 97.36 11.45 196 201689 14702 50388537
Dehydration 97.12 11.45 299 201586 152150 50251089
International normalised ratio increased 97.06 11.45 26 201859 43126 50360113
Vitamin D decreased 96.50 11.45 142 201743 8264 50394975
Syncope 95.51 11.45 165 201720 102837 50300402
Diarrhoea 95.15 11.45 1715 200170 586761 49816478
Body height decreased 94.46 11.45 145 201740 8763 50394476
Rash pruritic 92.93 11.45 408 201477 47438 50355801
Unresponsive to stimuli 92.34 11.45 8 201877 30601 50372638
C-telopeptide increased 92.11 11.45 22 201863 9 50403230
Tumour marker increased 91.87 11.45 94 201791 3746 50399493
Osteitis 91.42 11.45 84 201801 2926 50400313
Dermatitis 91.36 11.45 186 201699 14065 50389174
Metabolic acidosis 88.07 11.45 23 201862 38802 50364437
Mastication disorder 87.86 11.45 67 201818 1793 50401446
Neoplasm malignant 87.60 11.45 250 201635 23465 50379774
Infection 87.19 11.45 374 201511 172580 50230659
Sequestrectomy 87.13 11.45 49 201836 767 50402472
Anaphylactic reaction 86.94 11.45 54 201831 54001 50349238
Osteoporotic fracture 86.38 11.45 83 201802 3062 50400177
Gastrointestinal haemorrhage 86.35 11.45 99 201786 73222 50330017
Serotonin syndrome 85.14 11.45 3 201882 24710 50378529
Influenza like illness 84.92 11.45 453 201432 57006 50346233
Hypoxia 83.72 11.45 50 201835 51073 50352166
Upper limb fracture 82.13 11.45 190 201695 15683 50387556
Blood pressure decreased 81.73 11.45 62 201823 55847 50347392
Dental cleaning 81.64 11.45 21 201864 19 50403220
Loss of consciousness 81.39 11.45 185 201700 104168 50299071
Multiple organ dysfunction syndrome 81.35 11.45 50 201835 50287 50352952
Hypercalcaemia 81.28 11.45 241 201644 23111 50380128
Fall 81.06 11.45 1826 200059 333106 50070133
Encephalopathy 80.32 11.45 18 201867 33693 50369546
Respiratory arrest 80.14 11.45 12 201873 29997 50373242
Arthropathy 79.87 11.45 341 201544 157565 50245674
No adverse event 79.86 11.45 18 201867 33560 50369679
Sleep disorder due to a general medical condition 79.59 11.45 121 201764 7250 50395989
C-reactive protein abnormal 79.36 11.45 9 201876 27800 50375439
Osteonecrosis of external auditory canal 79.09 11.45 25 201860 74 50403165
Intentional self-injury 78.95 11.45 3 201882 23109 50380130
Alanine aminotransferase increased 78.80 11.45 145 201740 88214 50315025
Chest discomfort 78.47 11.45 157 201728 92565 50310674
Nasopharyngitis 77.33 11.45 452 201433 192475 50210764
Wheezing 77.24 11.45 80 201805 61967 50341272
Metastases to lymph nodes 76.83 11.45 116 201769 6908 50396331
Dry skin 76.18 11.45 358 201527 42833 50360406
Anxiety 76.13 11.45 407 201478 177199 50226040
Foetal exposure during pregnancy 75.27 11.45 10 201875 27349 50375890
Carbohydrate antigen 15-3 increased 74.74 11.45 50 201835 1082 50402157
Hyperparathyroidism 74.55 11.45 68 201817 2346 50400893
Irritable bowel syndrome 73.98 11.45 58 201827 51383 50351856
Metastases to spine 72.68 11.45 72 201813 2759 50400480
Joint noise 72.01 11.45 80 201805 3507 50399732
Chest pain 71.63 11.45 413 201472 176469 50226770
Discomfort 71.56 11.45 209 201676 108171 50295068
Injection site erythema 71.34 11.45 118 201767 74818 50328421
Type 2 diabetes mellitus 71.34 11.45 24 201861 34351 50368888
Gingival abscess 71.19 11.45 41 201844 673 50402566
Tooth erosion 70.68 11.45 35 201850 416 50402823
Mental status changes 69.12 11.45 29 201856 36243 50366996
Incorrect dose administered 69.11 11.45 55 201830 48359 50354880
PIK3CA-activated mutation 68.95 11.45 42 201843 768 50402471
Hyperkalaemia 68.18 11.45 55 201830 48034 50355205
Renal failure 67.98 11.45 209 201676 106424 50296815
Pancytopenia 67.96 11.45 146 201739 83884 50319355
Sedation 67.79 11.45 19 201866 30591 50372648
Drug withdrawal syndrome 67.05 11.45 10 201875 25071 50378168
Dental necrosis 66.15 11.45 24 201861 120 50403119
Aspartate aminotransferase increased 66.05 11.45 132 201753 77866 50325373
Oedema 65.43 11.45 112 201773 70069 50333170
Flushing 65.22 11.45 104 201781 66911 50336328
Oedema peripheral 64.39 11.45 368 201517 157593 50245646
Premature delivery 64.27 11.45 9 201876 23654 50379585
Sepsis 64.21 11.45 292 201593 132633 50270606
Drug reaction with eosinophilia and systemic symptoms 64.16 11.45 17 201868 28407 50374832
Fatigue 64.04 11.45 2247 199638 705354 49697885
Jaw fistula 63.74 11.45 19 201866 43 50403196
Heart rate decreased 63.65 11.45 33 201852 36464 50366775
Blood parathyroid hormone abnormal 63.56 11.45 26 201859 189 50403050
Product quality issue 63.25 11.45 22 201863 30836 50372403
Emotional distress 63.09 11.45 18 201867 28645 50374594
Fractured sacrum 62.19 11.45 54 201831 1744 50401495
Tremor 61.92 11.45 242 201643 114661 50288578
Delirium 61.63 11.45 38 201847 38154 50365085
Peripheral swelling 61.23 11.45 526 201359 205410 50197829
Blood pressure increased 61.04 11.45 298 201587 132834 50270405
Therapeutic response decreased 60.96 11.45 59 201826 47172 50356067
Psoriasis 60.84 11.45 114 201771 68886 50334353
Sinus tachycardia 60.71 11.45 7 201878 21347 50381892
Metastases to central nervous system 60.53 11.45 137 201748 11145 50392094
Asthma 59.91 11.45 171 201714 89166 50314073
Toxic epidermal necrolysis 59.39 11.45 7 201878 20985 50382254
Femoral neck fracture 59.39 11.45 107 201778 7383 50395856
Rhabdomyolysis 58.70 11.45 42 201843 38985 50364254
Hospice care 58.47 11.45 92 201793 5680 50397559
Vitamin D abnormal 58.33 11.45 22 201863 125 50403114
Migraine 58.25 11.45 134 201751 75146 50328093
Hallucination 58.25 11.45 60 201825 46597 50356642
Drug level increased 58.22 11.45 5 201880 19263 50383976
Cardiac failure congestive 57.70 11.45 160 201725 84222 50319017
Injection site reaction 57.35 11.45 69 201816 49963 50353276
Hypophosphataemia 56.54 11.45 112 201773 8302 50394937
Septic shock 56.33 11.45 88 201797 57087 50346152
Immobile 56.04 11.45 84 201801 4970 50398269
Spinal deformity 55.56 11.45 39 201846 915 50402324
Pulpitis dental 55.50 11.45 37 201848 796 50402443
Psychotic disorder 55.40 11.45 10 201875 21802 50381437
Living in residential institution 55.23 11.45 30 201855 437 50402802
Paraesthesia 54.70 11.45 726 201159 119517 50283722
Product dose omission issue 53.77 11.45 1031 200854 182807 50220432
Polymyalgia rheumatica 53.28 11.45 59 201826 2577 50400662
Liver function test abnormal 53.14 11.45 59 201826 44280 50358959
Haemoglobin decreased 53.12 11.45 294 201591 126922 50276317
Tooth resorption 52.85 11.45 16 201869 39 50403200
Dysarthria 52.74 11.45 43 201842 37360 50365879
Orthostatic hypotension 52.39 11.45 26 201859 29455 50373784
Dental discomfort 52.34 11.45 27 201858 352 50402887
Fluid retention 51.78 11.45 76 201809 50573 50352666
Depression 51.20 11.45 418 201467 165005 50238234
Impaired healing 50.99 11.45 463 201422 69323 50333916
Musculoskeletal stiffness 50.92 11.45 302 201583 128179 50275060
C-reactive protein increased 50.89 11.45 119 201766 66355 50336884
Cognitive disorder 50.41 11.45 61 201824 44062 50359177
Dental fistula 50.37 11.45 31 201854 578 50402661
Liver injury 50.30 11.45 18 201867 24788 50378451
Generalised tonic-clonic seizure 50.19 11.45 21 201864 26289 50376950
Sciatica 49.91 11.45 193 201692 21189 50382050
Blood glucose increased 49.69 11.45 134 201751 71190 50332049
Anaemia 49.14 11.45 710 201175 251746 50151493
Tibia fracture 49.08 11.45 74 201811 4401 50398838
Metastases to skin 48.77 11.45 42 201843 1341 50401898
Injury 48.49 11.45 75 201810 48850 50354389
Jaw fracture 48.15 11.45 54 201831 2392 50400847
Muscle spasticity 47.95 11.45 6 201879 17178 50386061
Neck pain 47.66 11.45 390 201495 56677 50346562
Dizziness 47.42 11.45 1037 200848 345332 50057907
Heart rate increased 47.41 11.45 154 201731 77096 50326143
Parathyroidectomy 47.31 11.45 22 201863 225 50403014
Stevens-Johnson syndrome 47.25 11.45 14 201871 21738 50381501
Scoliosis 47.19 11.45 90 201795 6486 50396753
Hyperhidrosis 47.12 11.45 190 201695 89236 50314003
Oral pain 46.73 11.45 211 201674 24822 50378417
Blood phosphorus decreased 46.40 11.45 66 201819 3723 50399516
Humerus fracture 45.98 11.45 97 201788 7521 50395718
Blister 45.95 11.45 180 201705 85238 50318001
Right ventricular failure 45.71 11.45 5 201880 15888 50387351
Menopausal symptoms 45.27 11.45 48 201837 1995 50401244
Injection site pruritus 44.98 11.45 57 201828 40354 50362885
Parathyroid disorder 44.85 11.45 28 201857 536 50402703
Adverse reaction 44.66 11.45 103 201782 8483 50394756
Pulmonary arterial hypertension 44.28 11.45 13 201872 20306 50382933
Traumatic fracture 43.86 11.45 28 201857 558 50402681
Hypervolaemia 43.08 11.45 24 201861 25475 50377764
Device dislocation 43.07 11.45 16 201869 21530 50381709
Gait disturbance 42.73 11.45 838 201047 149167 50254072
White blood cell count increased 42.58 11.45 64 201821 42176 50361063
Red blood cell sedimentation rate increased 42.50 11.45 33 201852 29383 50373856
Drug dependence 42.41 11.45 13 201872 19746 50383493
Eosinophilia 42.39 11.45 11 201874 18641 50384598
Caesarean section 42.35 11.45 6 201879 15633 50387606
Bronchitis 42.24 11.45 243 201642 103916 50299323
Medication error 42.22 11.45 49 201836 36055 50367184
Status epilepticus 41.85 11.45 3 201882 13403 50389836
Product substitution issue 41.52 11.45 4 201881 14053 50389186
Haematemesis 41.48 11.45 30 201855 27695 50375544
Prescribed overdose 40.98 11.45 5 201880 14595 50388644
Hand fracture 40.88 11.45 68 201817 4400 50398839
Drug ineffective for unapproved indication 40.57 11.45 17 201868 21264 50381975
Dental prosthesis placement 40.51 11.45 14 201871 59 50403180
Mouth swelling 40.48 11.45 63 201822 3853 50399386
Oral surgery 40.40 11.45 33 201852 978 50402261
Aggression 40.04 11.45 17 201868 21099 50382140
Parathyroid tumour 39.99 11.45 16 201869 109 50403130
Haematochezia 39.65 11.45 61 201824 39821 50363418
Osteoporosis 39.26 11.45 310 201575 44569 50358670
Deep vein thrombosis 39.09 11.45 155 201730 73149 50330090
Device failure 38.86 11.45 75 201810 5453 50397786
Staphylococcal infection 38.85 11.45 51 201834 35565 50367674
Nasal congestion 38.74 11.45 92 201793 51028 50352211
Musculoskeletal chest pain 38.47 11.45 161 201724 18325 50384914
Noninfective gingivitis 38.29 11.45 35 201850 1211 50402028
Cytomegalovirus infection 38.22 11.45 12 201873 17950 50385289
Oral infection 38.16 11.45 63 201822 4051 50399188
Spinal operation 38.12 11.45 80 201805 6180 50397059
Vitamin D deficiency 38.09 11.45 116 201769 11286 50391953
Dyskinesia 38.09 11.45 33 201852 27828 50375411
Blood alkaline phosphatase decreased 37.92 11.45 33 201852 1069 50402170
Infusion site pain 37.86 11.45 3 201882 12343 50390896
Abdominal lymphadenopathy 37.72 11.45 27 201858 654 50402585
Blood pressure fluctuation 37.36 11.45 53 201832 35770 50367469
Coronary artery disease 37.36 11.45 38 201847 29688 50373551
Pulmonary hypertension 37.33 11.45 47 201838 33370 50369869
Irritability 37.27 11.45 35 201850 28391 50374848
Body temperature increased 37.23 11.45 42 201843 31299 50371940
Walking aid user 36.63 11.45 80 201805 6353 50396886
Circulatory collapse 36.51 11.45 17 201868 19983 50383256
Disorientation 36.51 11.45 53 201832 35431 50367808
Oestrogen deficiency 36.28 11.45 16 201869 143 50403096
Bone resorption test abnormal 36.18 11.45 9 201876 6 50403233
Hyperparathyroidism secondary 35.89 11.45 35 201850 1315 50401924
Poisoning 35.52 11.45 4 201881 12425 50390814
Acute respiratory distress syndrome 35.44 11.45 20 201865 21079 50382160
Drug-induced liver injury 35.21 11.45 36 201849 28059 50375180
Hemiparesis 35.14 11.45 18 201867 20030 50383209
Product prescribing error 35.02 11.45 20 201865 20941 50382298
Trismus 34.80 11.45 54 201831 3294 50399945
Abdominal pain upper 34.59 11.45 438 201447 158871 50244368
Cyanosis 34.42 11.45 9 201876 15175 50388064
Hypokalaemia 34.23 11.45 208 201677 87784 50315455
Paraesthesia oral 34.19 11.45 117 201768 12104 50391135
Haematoma 33.99 11.45 43 201842 30467 50372772
Bone lesion 33.75 11.45 68 201817 5102 50398137
Radius fracture 33.69 11.45 52 201833 3157 50400082
Withdrawal syndrome 33.62 11.45 14 201871 17576 50385663
Bronchospasm 33.30 11.45 9 201876 14845 50388394
Pneumonia aspiration 33.20 11.45 45 201840 30959 50372280
Extrapyramidal disorder 33.11 11.45 4 201881 11766 50391473
Hypophosphatasia 33.00 11.45 8 201877 4 50403235
Ventricular tachycardia 32.91 11.45 11 201874 15810 50387429
Lichen planus 32.80 11.45 40 201845 1939 50401300
Blood creatine phosphokinase increased 32.80 11.45 34 201851 26333 50376906
Metastasis 32.79 11.45 61 201824 4314 50398925
Vision blurred 32.68 11.45 182 201703 78465 50324774
Haematocrit decreased 32.43 11.45 56 201829 34920 50368319
Obstructive airways disorder 32.35 11.45 11 201874 15641 50387598
Respiratory distress 31.90 11.45 45 201840 30444 50372795
Immune system disorder 31.69 11.45 88 201797 8129 50395110
Coagulopathy 31.62 11.45 16 201869 17928 50385311
Sinus bradycardia 31.48 11.45 7 201878 13176 50390063
Palpitations 31.46 11.45 234 201651 94272 50308967
Rash papular 31.26 11.45 116 201769 12488 50390751
Pancreatitis 31.26 11.45 78 201807 42536 50360703
Atrial fibrillation 31.04 11.45 258 201627 101487 50301752
Disease recurrence 31.00 11.45 21 201864 20060 50383179
Adverse drug reaction 30.99 11.45 347 201538 54875 50348364
Blood bilirubin increased 30.90 11.45 50 201835 31988 50371251
Bone marrow failure 30.70 11.45 39 201846 27585 50375654
Acute myeloid leukaemia 30.46 11.45 11 201874 15063 50388176
Pancreatitis acute 30.43 11.45 30 201855 23782 50379457
Paranoia 30.42 11.45 3 201882 10345 50392894
Ear pain 30.26 11.45 205 201680 28078 50375161
Oral cavity fistula 30.02 11.45 23 201862 620 50402619
Forearm fracture 29.93 11.45 20 201865 432 50402807
Feeling abnormal 29.87 11.45 683 201202 124809 50278430
Photophobia 29.85 11.45 11 201874 14876 50388363
Abnormal behaviour 29.76 11.45 21 201864 19637 50383602
Intentional product misuse 29.48 11.45 92 201793 46642 50356597
Diabetes mellitus inadequate control 29.40 11.45 8 201877 13137 50390102
Respiratory rate increased 29.39 11.45 5 201880 11380 50391859
Myocardial infarction 29.36 11.45 221 201664 88806 50314433
Tubulointerstitial nephritis 29.24 11.45 12 201873 15199 50388040
Pulmonary oedema 29.03 11.45 99 201786 48839 50354400
Anuria 28.89 11.45 5 201880 11239 50392000
Nightmare 28.86 11.45 14 201871 16072 50387167
Denture wearer 28.85 11.45 15 201870 199 50403040
Tachypnoea 28.84 11.45 11 201874 14566 50388673
Acute respiratory failure 28.63 11.45 44 201841 28738 50374501
Hepatic steatosis 28.61 11.45 33 201852 24351 50378888
Hepatitis 28.58 11.45 51 201834 31402 50371837
Myoclonus 28.50 11.45 11 201874 14459 50388780
Unevaluable event 28.42 11.45 295 201590 45771 50357468
Labelled drug-drug interaction medication error 28.42 11.45 4 201881 10473 50392766
Gingival erythema 28.40 11.45 22 201863 603 50402636
Bacteraemia 28.38 11.45 11 201874 14422 50388817
Upper respiratory tract infection 28.20 11.45 151 201734 65747 50337492
Accidental overdose 28.11 11.45 22 201863 19511 50383728
Blood creatinine increased 28.09 11.45 183 201702 75977 50327262
Cough 28.09 11.45 740 201145 240524 50162715
Thrombocytopenia 28.09 11.45 350 201535 127323 50275916
COVID-19 27.95 11.45 94 201791 46568 50356671
Gingival operation 27.93 11.45 12 201873 100 50403139
Melaena 27.76 11.45 40 201845 26824 50376415
Metastases to pleura 27.73 11.45 30 201855 1276 50401963
Back disorder 27.73 11.45 91 201794 9214 50394025
Vitamin D increased 27.63 11.45 21 201864 559 50402680
Pneumocystis jirovecii pneumonia 27.49 11.45 12 201873 14651 50388588
Periodontal disease 27.47 11.45 32 201853 1478 50401761
Agranulocytosis 27.36 11.45 27 201858 21394 50381845
Diabetic ketoacidosis 27.18 11.45 19 201866 17853 50385386
Rash macular 27.13 11.45 150 201735 19127 50384112
Hallucination, auditory 27.07 11.45 5 201880 10723 50392516
Scab 27.03 11.45 72 201813 6490 50396749
Contusion 26.81 11.45 302 201583 111881 50291358
Bone graft 26.80 11.45 24 201861 808 50402431
Onychoclasis 26.66 11.45 62 201823 5134 50398105
Obesity 26.63 11.45 17 201868 16758 50386481
Palliative care 26.62 11.45 17 201868 339 50402900
Injury associated with device 26.61 11.45 46 201839 3071 50400168
Haemoptysis 26.50 11.45 38 201847 25535 50377704
Cardiogenic shock 25.89 11.45 15 201870 15584 50387655
Intercepted medication error 25.69 11.45 18 201867 421 50402818
Respiratory depression 25.60 11.45 8 201877 12002 50391237
Cataract operation 25.57 11.45 53 201832 4058 50399181
Exostosis 25.44 11.45 103 201782 11550 50391689
Haemorrhage 25.42 11.45 118 201767 53323 50349916
Drug resistance 25.35 11.45 23 201862 18966 50384273
Oral discomfort 25.33 11.45 80 201805 7937 50395302
Angioedema 25.33 11.45 72 201813 37604 50365635
Acidosis 25.31 11.45 5 201880 10222 50393017
Posterior reversible encephalopathy syndrome 25.29 11.45 14 201871 14914 50388325
Renal tubular necrosis 25.10 11.45 5 201880 10163 50393076
Sputum discoloured 25.06 11.45 11 201874 13384 50389855
Injection site bruising 24.91 11.45 70 201815 36698 50366541
Chemotherapy 24.88 11.45 29 201856 1340 50401899
Hepatocellular injury 24.55 11.45 41 201844 25906 50377333
Restlessness 24.55 11.45 39 201846 25134 50378105
Disturbance in attention 24.53 11.45 55 201830 31131 50372108
Bone density increased 24.52 11.45 18 201867 454 50402785
Cholelithiasis 24.49 11.45 74 201811 37899 50365340
Bone swelling 24.31 11.45 27 201858 1183 50402056
Altered state of consciousness 24.28 11.45 31 201854 21879 50381360
Inappropriate antidiuretic hormone secretion 24.26 11.45 11 201874 13132 50390107
Dementia 24.22 11.45 127 201758 15870 50387369
Prescribed underdose 24.20 11.45 17 201868 15932 50387307
Hyperglycaemia 24.16 11.45 70 201815 36335 50366904
Nerve compression 24.08 11.45 75 201810 7387 50395852
Amnesia 24.05 11.45 87 201798 42173 50361066
Renal injury 24.04 11.45 3 201882 8608 50394631
Basal cell carcinoma 23.92 11.45 35 201850 23321 50379918
Hypothermia 23.89 11.45 9 201876 12007 50391232
Malpositioned teeth 23.74 11.45 7 201878 15 50403224
Hypertension 23.74 11.45 651 201234 210552 50192687
Blood creatinine abnormal 23.71 11.45 40 201845 2618 50400621
Therapeutic product effect incomplete 23.62 11.45 242 201643 91273 50311966
Wrong technique in product usage process 23.52 11.45 331 201554 55179 50348060
Sleep disorder due to general medical condition, insomnia type 23.50 11.45 57 201828 31390 50371849
Metaphyseal corner fracture 23.48 11.45 8 201877 32 50403207
Calcinosis 23.37 11.45 33 201852 1849 50401390
Electrocardiogram QT prolonged 23.26 11.45 117 201768 51769 50351470
Ataxia 23.25 11.45 13 201872 13773 50389466
Parathyroid tumour malignant 23.14 11.45 7 201878 17 50403222
Metastases to peritoneum 23.14 11.45 41 201844 2792 50400447
Affect lability 23.12 11.45 4 201881 8994 50394245
Injection site swelling 23.12 11.45 87 201798 41686 50361553
Shock haemorrhagic 23.07 11.45 3 201882 8341 50394898
Pulmonary embolism 23.05 11.45 277 201608 101427 50301812
Device fastener issue 23.03 11.45 6 201879 6 50403233
Gingival cyst 23.03 11.45 6 201879 6 50403233
Bone cancer 23.02 11.45 26 201859 1161 50402078
Leukocytosis 22.96 11.45 34 201851 22545 50380694
Injection site haemorrhage 22.84 11.45 31 201854 21315 50381924
Hypoaesthesia oral 22.76 11.45 94 201791 10634 50392605
Pollakiuria 22.67 11.45 168 201717 23683 50379556
Akathisia 22.65 11.45 3 201882 8226 50395013
Bone metabolism biochemical marker increased 22.64 11.45 5 201880 0 50403239
Orthodontic procedure 22.64 11.45 5 201880 0 50403239
Aphasia 22.62 11.45 50 201835 28444 50374795
Rehabilitation therapy 22.52 11.45 27 201858 1286 50401953
Rales 22.46 11.45 6 201879 9972 50393267
Hip surgery 22.40 11.45 39 201846 2619 50400620
Acute coronary syndrome 22.34 11.45 5 201880 9369 50393870
Osteolysis 22.18 11.45 38 201847 2519 50400720
Vaginal haemorrhage 22.13 11.45 40 201845 24511 50378728
Shock 22.08 11.45 30 201855 20620 50382619
Oral disorder 21.86 11.45 75 201810 7769 50395470
Macule 21.83 11.45 29 201856 1533 50401706
Device malfunction 21.80 11.45 17 201868 15104 50388135
Osteocalcin decreased 21.71 11.45 6 201879 9 50403230
Root canal infection 21.67 11.45 13 201872 231 50403008
Angina pectoris 21.58 11.45 45 201840 26143 50377096
Cholesteatoma 21.56 11.45 11 201874 140 50403099
Amenorrhoea 21.31 11.45 4 201881 8480 50394759
Gingival ulceration 21.28 11.45 21 201864 801 50402438
Ankle fracture 21.24 11.45 121 201764 15601 50387638
Blood glucose decreased 20.99 11.45 25 201860 18186 50385053
Patella fracture 20.97 11.45 31 201854 1811 50401428
Gastroenteritis 20.93 11.45 38 201847 23243 50379996
Delusion 20.87 11.45 8 201877 10561 50392678
Ventricular fibrillation 20.84 11.45 8 201877 10551 50392688
Dysstasia 20.79 11.45 132 201753 17687 50385552
Coordination abnormal 20.75 11.45 10 201875 11524 50391715
Hyperthermia 20.73 11.45 3 201882 7693 50395546
Adrenal insufficiency 20.55 11.45 16 201869 14227 50389012
Cardiac failure 20.48 11.45 199 201686 75841 50327398
Oliguria 20.37 11.45 4 201881 8212 50395027
Generalised oedema 20.35 11.45 15 201870 13716 50389523
Bronchopulmonary aspergillosis 20.35 11.45 3 201882 7589 50395650
Abscess oral 20.35 11.45 26 201859 1322 50401917
Creatinine renal clearance decreased 20.33 11.45 11 201874 11870 50391369
Oral mucosal erythema 20.24 11.45 26 201859 1329 50401910
Skin exfoliation 20.14 11.45 214 201671 33398 50369841
Atelectasis 20.09 11.45 26 201859 18244 50384995
Hepatic failure 20.05 11.45 64 201821 32219 50371020
Carcinoembryonic antigen increased 20.04 11.45 27 201858 1447 50401792
Gastrointestinal disorder 20.00 11.45 261 201624 94195 50309044
Dental prosthesis user 19.94 11.45 8 201877 55 50403184
Musculoskeletal disorder 19.92 11.45 128 201757 17221 50386018
Gestational diabetes 19.90 11.45 3 201882 7462 50395777
Therapy interrupted 19.86 11.45 31 201854 20121 50383118
Kyphosis 19.77 11.45 34 201851 2261 50400978
Acute hepatic failure 19.74 11.45 20 201865 15657 50387582
Sleep apnoea syndrome 19.68 11.45 41 201844 23827 50379412
Weight bearing difficulty 19.67 11.45 34 201851 2270 50400969
Schizophrenia 19.65 11.45 3 201882 7394 50395845
Acute myocardial infarction 19.63 11.45 56 201829 29217 50374022
Peri-implantitis 19.63 11.45 7 201878 33 50403206
Pain of skin 19.59 11.45 73 201812 7874 50395365
Blood pressure systolic increased 19.50 11.45 74 201811 35375 50367864
Lymphoedema 19.41 11.45 80 201805 9042 50394197
Adverse event 19.37 11.45 263 201622 43500 50359739
Hair disorder 19.36 11.45 21 201864 896 50402343
Pleural neoplasm 19.25 11.45 12 201873 229 50403010
Progressive multifocal leukoencephalopathy 19.04 11.45 11 201874 11446 50391793
Lung neoplasm malignant 18.88 11.45 116 201769 15368 50387871
Hallucination, visual 18.86 11.45 23 201862 16559 50386680
Panic attack 18.83 11.45 30 201855 19312 50383927
Muscle tightness 18.70 11.45 86 201799 10194 50393045
Vertebroplasty 18.67 11.45 13 201872 301 50402938
Triple negative breast cancer 18.63 11.45 9 201876 101 50403138
Mastectomy 18.60 11.45 26 201859 1443 50401796
Clavicle fracture 18.41 11.45 38 201847 2901 50400338
Ocular hyperaemia 18.35 11.45 33 201852 20259 50382980
Blood pressure diastolic decreased 18.33 11.45 24 201861 16757 50386482
Oral neoplasm benign 18.29 11.45 5 201880 7 50403232
Productive cough 18.24 11.45 129 201756 52565 50350674
Hepatic function abnormal 18.12 11.45 68 201817 32613 50370626
Lip and/or oral cavity cancer 18.09 11.45 13 201872 317 50402922
Hepatic cytolysis 18.00 11.45 5 201880 8098 50395141
Mental disorder 17.94 11.45 38 201847 21953 50381286
Proteinuria 17.86 11.45 24 201861 16573 50386666
Platelet count increased 17.80 11.45 19 201866 14521 50388718
Speech disorder 17.80 11.45 77 201808 35471 50367768
VIth nerve paresis 17.63 11.45 8 201877 77 50403162
Hypoaesthesia 17.62 11.45 647 201238 126610 50276629
Gingival injury 17.61 11.45 6 201879 24 50403215
Tricuspid valve incompetence 17.61 11.45 15 201870 12755 50390484
Aspergillus infection 17.60 11.45 3 201882 6818 50396421
Limb discomfort 17.48 11.45 161 201724 24196 50379043
Deformity 17.45 11.45 5 201880 7935 50395304
Blood urea increased 17.43 11.45 43 201842 23542 50379697
Wrong product administered 17.41 11.45 54 201831 5306 50397933
Pallor 17.37 11.45 42 201843 23157 50380082
CYP3A4 polymorphism 17.36 11.45 8 201877 80 50403159
Hypovolaemia 17.35 11.45 8 201877 9457 50393782
Anger 17.30 11.45 12 201873 11321 50391918
Ulna fracture 17.27 11.45 21 201864 1015 50402224
Pseudomonas infection 17.24 11.45 8 201877 9422 50393817
Metastases to bladder 17.11 11.45 10 201875 169 50403070
Heart rate irregular 17.04 11.45 32 201853 19328 50383911
Catheter site injury 17.01 11.45 9 201876 124 50403115
Epilepsy 16.99 11.45 38 201847 21529 50381710
Lip exfoliation 16.93 11.45 15 201870 498 50402741
Vertebral wedging 16.87 11.45 5 201880 11 50403228
Thrombotic microangiopathy 16.79 11.45 7 201878 8784 50394455
Ankylosing spondylitis 16.72 11.45 4 201881 7161 50396078
Malocclusion 16.70 11.45 8 201877 88 50403151
Metastases to adrenals 16.62 11.45 17 201868 677 50402562
Drug level decreased 16.58 11.45 3 201882 6530 50396709
Cerebral haemorrhage 16.54 11.45 54 201831 26998 50376241
Haemorrhage intracranial 16.50 11.45 15 201870 12359 50390880
Pre-existing condition improved 16.49 11.45 4 201881 7093 50396146
Upper gastrointestinal haemorrhage 16.45 11.45 24 201861 16011 50387228
Presyncope 16.44 11.45 46 201839 24152 50379087
Mood altered 16.43 11.45 16 201869 12757 50390482
Tenosynovitis 16.37 11.45 11 201874 10554 50392685
Osteochondrosis 16.36 11.45 21 201864 1073 50402166
Allergy to plants 16.30 11.45 16 201869 606 50402633
Eye irritation 16.29 11.45 27 201858 17113 50386126
Gingival discolouration 16.28 11.45 11 201874 242 50402997
Bladder cancer 16.27 11.45 39 201846 3293 50399946
Parathyroid tumour benign 16.26 11.45 16 201869 608 50402631
Stress 16.13 11.45 137 201748 53656 50349583
Activated partial thromboplastin time prolonged 16.12 11.45 3 201882 6399 50396840
Product administration error 16.11 11.45 34 201851 19665 50383574
Colitis 16.09 11.45 89 201796 38440 50364799
Bone marrow oedema 16.07 11.45 18 201867 796 50402443
Infusion site extravasation 16.07 11.45 4 201881 6972 50396267
Dental cyst 16.07 11.45 6 201879 33 50403206
Injection site warmth 16.02 11.45 19 201866 13847 50389392
Vertebral lesion 16.00 11.45 14 201871 457 50402782
Decreased immune responsiveness 15.99 11.45 43 201842 3898 50399341
Eastern Cooperative Oncology Group performance status worsened 15.96 11.45 16 201869 622 50402617
Drug eruption 15.95 11.45 45 201840 23561 50379678
Skin necrosis 15.94 11.45 12 201873 10855 50392384
Central nervous system lesion 15.93 11.45 9 201876 9480 50393759
Breast cancer recurrent 15.90 11.45 42 201843 3766 50399473
Injected limb mobility decreased 15.89 11.45 4 201881 3 50403236
Dental paraesthesia 15.89 11.45 4 201881 3 50403236
Panniculitis 15.88 11.45 7 201878 8496 50394743
Medial tibial stress syndrome 15.80 11.45 8 201877 100 50403139
Febrile bone marrow aplasia 15.80 11.45 3 201882 6308 50396931
Inflammation 15.73 11.45 148 201737 56764 50346475
Adnexa uteri mass 15.72 11.45 14 201871 468 50402771
Cancer pain 15.68 11.45 33 201852 2554 50400685
Subarachnoid haemorrhage 15.68 11.45 12 201873 10764 50392475
Spinal disorder 15.65 11.45 70 201815 8200 50395039
Facial pain 15.62 11.45 66 201819 7543 50395696
Thyroid operation 15.61 11.45 9 201876 148 50403091
Myocardial ischaemia 15.58 11.45 14 201871 11599 50391640
Pulmonary fibrosis 15.49 11.45 48 201837 24389 50378850
Chronic kidney disease 15.47 11.45 94 201791 39677 50363562
Electrolyte imbalance 15.45 11.45 28 201857 17141 50386098
Visual impairment 15.45 11.45 186 201699 68089 50335150
Haemodialysis 15.43 11.45 7 201878 8355 50394884
Psychomotor hyperactivity 15.36 11.45 9 201876 9292 50393947
Hypercalcaemic nephropathy 15.36 11.45 4 201881 4 50403235
Mitral valve incompetence 15.27 11.45 29 201856 17442 50385797
Cardiomegaly 15.27 11.45 25 201860 15920 50387319
Osteomalacia 15.26 11.45 16 201869 656 50402583
Intervertebral disc protrusion 15.24 11.45 136 201749 20257 50382982
Blood pressure abnormal 15.23 11.45 95 201790 12652 50390587
Cellulitis 15.21 11.45 380 201505 70418 50332821
Myelodysplastic syndrome 15.18 11.45 23 201862 15109 50388130
Bone deformity 15.16 11.45 14 201871 491 50402748
Myelosuppression 15.11 11.45 19 201866 13498 50389741
Oral pustule 15.11 11.45 6 201879 40 50403199
Rectal haemorrhage 15.06 11.45 91 201794 38467 50364772
Liver function test increased 15.05 11.45 52 201833 25554 50377685
Clostridium difficile colitis 15.03 11.45 30 201855 17712 50385527
Cholecystitis 14.99 11.45 20 201865 13851 50389388
Hypoaesthesia teeth 14.86 11.45 6 201879 42 50403197
Arthritis 14.83 11.45 452 201433 86269 50316970
Conjunctivitis 14.83 11.45 26 201859 16119 50387120
Demyelination 14.80 11.45 3 201882 6023 50397216
Brachiocephalic vein thrombosis 14.77 11.45 7 201878 75 50403164
Dyspnoea exertional 14.69 11.45 132 201753 51101 50352138
Subdural haematoma 14.68 11.45 18 201867 12929 50390310
Granuloma annulare 14.65 11.45 14 201871 513 50402726
Fracture pain 14.62 11.45 12 201873 358 50402881
Malabsorption 14.60 11.45 40 201845 3666 50399573
Hepatic lesion 14.55 11.45 42 201843 3966 50399273
Pulmonary congestion 14.51 11.45 24 201861 15223 50388016
Degenerative bone disease 14.51 11.45 6 201879 45 50403194
Crying 14.48 11.45 38 201847 20378 50382861
Rash erythematous 14.43 11.45 207 201678 34645 50368594
Giant cell arteritis 14.43 11.45 26 201859 1794 50401445
Cardiotoxicity 14.42 11.45 5 201880 7022 50396217
Inguinal hernia repair 14.40 11.45 6 201879 46 50403193
Pulmonary tumour thrombotic microangiopathy 14.29 11.45 6 201879 47 50403192
Muscle rigidity 14.23 11.45 11 201874 9818 50393421
Skin haemorrhage 14.20 11.45 60 201825 6858 50396381
Pleural disorder 14.18 11.45 14 201871 534 50402705
Diverticulitis 14.11 11.45 198 201687 32984 50370255
Transaminases increased 14.10 11.45 60 201825 27764 50375475
Gastroenteritis viral 14.08 11.45 34 201851 18752 50384487
Acetabulum fracture 14.05 11.45 10 201875 240 50402999
Bone sequestrum 14.01 11.45 22 201863 1356 50401883
Parkinsonism 14.00 11.45 9 201876 8838 50394401
Skin disorder 13.94 11.45 152 201733 23878 50379361
Encephalitis 13.90 11.45 6 201879 7374 50395865
Sternal fracture 13.88 11.45 27 201858 1975 50401264
Rash maculo-papular 13.78 11.45 57 201828 26584 50376655
General physical health deterioration 13.76 11.45 448 201437 141986 50261253
Small intestinal obstruction 13.76 11.45 27 201858 16041 50387198
Ventricular extrasystoles 13.72 11.45 13 201872 10503 50392736
Hepatic encephalopathy 13.68 11.45 11 201874 9625 50393614
Breath sounds abnormal 13.65 11.45 7 201878 7785 50395454
Platelet count decreased 13.61 11.45 302 201583 100424 50302815
Osteosarcoma recurrent 13.58 11.45 3 201882 0 50403239
C-telopeptide 13.58 11.45 3 201882 0 50403239
Bone giant cell tumour malignant 13.58 11.45 3 201882 0 50403239
Blood 1,25-dihydroxycholecalciferol increased 13.58 11.45 3 201882 0 50403239
Masticatory pain 13.58 11.45 3 201882 0 50403239
Thyroid calcification 13.58 11.45 3 201882 0 50403239
Serum procollagen type I N-terminal propeptide decreased 13.58 11.45 3 201882 0 50403239
Urine abnormality 13.58 11.45 4 201881 6234 50397005
Urinary retention 13.56 11.45 56 201829 26134 50377105
Tachyphylaxis 13.56 11.45 10 201875 254 50402985
Diffuse large B-cell lymphoma 13.53 11.45 3 201882 5659 50397580
Oligodipsia 13.47 11.45 5 201880 27 50403212
Urethritis noninfective 13.43 11.45 4 201881 9 50403230
Chronic leukaemia 13.43 11.45 4 201881 9 50403230
Mucosal pain 13.43 11.45 4 201881 9 50403230
Eye pain 13.42 11.45 63 201822 28386 50374853
Jaundice 13.38 11.45 57 201828 26372 50376867
Fibula fracture 13.38 11.45 34 201851 2978 50400261
Angina unstable 13.37 11.45 5 201880 6701 50396538
Haemophagocytic lymphohistiocytosis 13.36 11.45 9 201876 8624 50394615
Ovarian cyst 13.35 11.45 22 201863 13974 50389265
Tooth discolouration 13.34 11.45 17 201868 862 50402377
Hypotonia 13.25 11.45 8 201877 8126 50395113
Hypercalcaemia of malignancy 13.24 11.45 8 201877 144 50403095
Osteosclerosis 13.24 11.45 37 201848 3430 50399809
Carcinoid tumour pulmonary 13.23 11.45 12 201873 411 50402828
Periprosthetic fracture 13.20 11.45 12 201873 412 50402827
Hepatitis cholestatic 13.17 11.45 4 201881 6113 50397126
Dermatitis allergic 13.08 11.45 19 201866 12701 50390538
Onychalgia 13.07 11.45 16 201869 779 50402460
Colitis ulcerative 13.03 11.45 30 201855 16824 50386415
Toxic encephalopathy 13.03 11.45 3 201882 5512 50397727
Acute generalised exanthematous pustulosis 12.95 11.45 10 201875 8928 50394311
Apathy 12.90 11.45 7 201878 7541 50395698
Bone scan abnormal 12.89 11.45 11 201874 347 50402892
Fear 12.85 11.45 24 201861 14525 50388714
Injection site urticaria 12.81 11.45 18 201867 12199 50391040
Gallbladder disorder 12.78 11.45 30 201855 16712 50386527
Enteritis 12.69 11.45 6 201879 6989 50396250
Blood cholesterol abnormal 12.68 11.45 28 201857 2240 50400999
Pulmonary haemorrhage 12.68 11.45 5 201880 6487 50396752
Injection site induration 12.67 11.45 9 201876 8388 50394851
Mood swings 12.66 11.45 28 201857 15926 50387313
Eosinophil count increased 12.64 11.45 10 201875 8820 50394419
Aspiration 12.63 11.45 11 201874 9253 50393986
Carbohydrate antigen 19-9 increased 12.55 11.45 8 201877 159 50403080
Bone fistula 12.52 11.45 6 201879 66 50403173
Quality of life decreased 12.51 11.45 54 201831 6229 50397010
Sinus congestion 12.38 11.45 23 201862 13948 50389291
Varicophlebitis 12.38 11.45 4 201881 13 50403226
Infusion site erythema 12.34 11.45 10 201875 8717 50394522
Urine output decreased 12.34 11.45 14 201871 10407 50392832
Hypercalciuria 12.33 11.45 9 201876 225 50403014
Hot flush 12.30 11.45 246 201639 43923 50359316
Thinking abnormal 12.28 11.45 12 201873 9555 50393684
Cardiac murmur 12.22 11.45 15 201870 10769 50392470
Metastases to neck 12.21 11.45 6 201879 70 50403169
Pneumonia viral 12.18 11.45 6 201879 6828 50396411
Face oedema 12.06 11.45 34 201851 17805 50385434
Device difficult to use 12.01 11.45 13 201872 9873 50393366
Fibromyalgia 11.99 11.45 118 201767 44860 50358379
Skin sensitisation 11.97 11.45 15 201870 748 50402491
Bipolar disorder 11.94 11.45 6 201879 6751 50396488
Blood pressure systolic decreased 11.92 11.45 4 201881 5735 50397504
Nail growth abnormal 11.92 11.45 12 201873 469 50402770
Jaw cyst 11.89 11.45 7 201878 120 50403119
Rhinorrhoea 11.87 11.45 140 201745 51443 50351796
Troponin increased 11.86 11.45 9 201876 8109 50395130
Lipase increased 11.82 11.45 10 201875 8531 50394708
Ear disorder 11.79 11.45 34 201851 3209 50400030
Multiple sclerosis 11.79 11.45 42 201843 20451 50382788
Abnormal dreams 11.77 11.45 12 201873 9365 50393874
Pathogen resistance 11.75 11.45 4 201881 5685 50397554
Callus formation delayed 11.74 11.45 4 201881 16 50403223
Transfusion 11.65 11.45 21 201864 12884 50390355
Vascular fragility 11.64 11.45 7 201878 125 50403114
Papule 11.63 11.45 41 201844 4304 50398935
Motor dysfunction 11.61 11.45 9 201876 8022 50395217
Nephropathy toxic 11.61 11.45 9 201876 8020 50395219
Hepatic cancer 11.58 11.45 34 201851 3241 50399998
Blood potassium decreased 11.57 11.45 93 201792 36852 50366387
Metastases to vagina 11.55 11.45 4 201881 17 50403222
Tartrate-resistant acid phosphatase increased 11.52 11.45 3 201882 3 50403236
Parathyroid hormone-related protein increased 11.52 11.45 3 201882 3 50403236
Extradural neoplasm 11.52 11.45 3 201882 3 50403236
Bone erosion 11.50 11.45 18 201867 11669 50391570
Tuberculosis 11.45 11.45 14 201871 10069 50393170

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis of jaw 7496.78 13.80 2083 36879 14427 29521138
Off label use 4104.42 13.80 3255 35707 297545 29238020
Death 1849.69 13.80 2243 36719 339841 29195724
Hypocalcaemia 1770.94 13.80 750 38212 19915 29515650
Terminal state 585.97 13.80 207 38755 3287 29532278
Prostatic specific antigen increased 350.78 13.80 214 38748 12350 29523215
Tooth disorder 309.58 13.80 179 38783 9350 29526215
Metastases to bone 308.52 13.80 181 38781 9717 29525848
Tooth extraction 294.61 13.80 132 38830 3997 29531568
Investigation 248.71 13.80 77 38885 787 29534778
Pain in jaw 226.12 13.80 158 38804 11483 29524082
Hospitalisation 225.35 13.80 290 38672 45698 29489867
Bone pain 223.28 13.80 189 38773 18263 29517302
Malignant neoplasm progression 215.78 13.80 365 38597 73494 29462071
Atypical femur fracture 203.74 13.80 52 38910 239 29535326
Prostate cancer metastatic 179.34 13.80 100 38862 4866 29530699
Exposed bone in jaw 175.26 13.80 68 38894 1418 29534147
Blood calcium decreased 172.21 13.80 122 38840 9060 29526505
Hypophosphataemia 166.72 13.80 113 38849 7811 29527754
Blood parathyroid hormone increased 156.25 13.80 61 38901 1294 29534271
Toxicity to various agents 142.49 13.80 28 38934 173633 29361932
Jaw disorder 139.36 13.80 63 38899 1947 29533618
Osteomyelitis 129.26 13.80 122 38840 13587 29521978
Prostate cancer 117.20 13.80 156 38806 25371 29510194
Osteitis 114.55 13.80 50 38912 1419 29534146
Drug ineffective 114.06 13.80 190 38772 362980 29172585
Hypercalcaemia 107.96 13.80 107 38855 12652 29522913
Completed suicide 101.49 13.80 4 38958 90242 29445323
Toothache 101.38 13.80 73 38889 5559 29530006
Drug interaction 93.48 13.80 74 38888 197311 29338254
Bone density abnormal 84.63 13.80 19 38943 43 29535522
Occupational exposure to product 82.33 13.80 26 38936 285 29535280
Hot flush 79.44 13.80 98 38864 14772 29520793
Back pain 76.83 13.80 302 38660 101982 29433583
Dental care 74.66 13.80 22 38940 187 29535378
Condition aggravated 71.56 13.80 53 38909 146242 29389323
Hypotension 71.26 13.80 91 38871 194263 29341302
Abscess jaw 69.21 13.80 28 38934 654 29534911
Hormone-refractory prostate cancer 67.90 13.80 27 38935 602 29534963
Spinal fracture 67.48 13.80 61 38901 6425 29529140
Acute kidney injury 62.60 13.80 163 38799 265104 29270461
Tooth fracture 61.64 13.80 43 38919 3113 29532452
Metastases to lung 61.18 13.80 63 38899 7792 29527773
Incorrect route of product administration 60.64 13.80 73 38889 10728 29524837
Cardiac arrest 58.28 13.80 20 38942 85571 29449994
Osteonecrosis 58.04 13.80 80 38882 13439 29522126
Dental implantation 57.23 13.80 14 38948 52 29535513
Femur fracture 56.14 13.80 57 38905 6934 29528631
Pathological fracture 53.95 13.80 43 38919 3812 29531753
Blood calcium abnormal 53.89 13.80 21 38941 443 29535122
Overdose 53.74 13.80 19 38943 79800 29455765
Jaw operation 53.69 13.80 17 38945 188 29535377
Accidental exposure to product 52.87 13.80 68 38894 10685 29524880
Tetany 49.89 13.80 22 38940 640 29534925
Metastasis 49.60 13.80 39 38923 3390 29532175
Dental caries 46.83 13.80 41 38921 4139 29531426
Metastases to lymph nodes 46.21 13.80 40 38922 3977 29531588
Tooth loss 45.16 13.80 38 38924 3636 29531929
Bone fissure 45.05 13.80 10 38952 21 29535544
Fracture 44.37 13.80 47 38915 6006 29529559
Tooth abscess 44.17 13.80 43 38919 4971 29530594
Impaired healing 43.51 13.80 70 38892 13488 29522077
Thoracic vertebral fracture 42.05 13.80 25 38937 1373 29534192
Fatigue 41.67 13.80 616 38346 316205 29219360
Endodontic procedure 40.82 13.80 16 38946 343 29535222
Agitation 40.49 13.80 9 38953 51295 29484270
Bradycardia 40.27 13.80 18 38944 65611 29469954
Gastrointestinal haemorrhage 39.90 13.80 28 38934 79505 29456060
Blood phosphorus decreased 38.84 13.80 31 38931 2754 29532811
Exostosis of jaw 38.25 13.80 11 38951 85 29535480
Bone density decreased 37.83 13.80 25 38937 1655 29533910
Loose tooth 36.80 13.80 21 38941 1068 29534497
Cardio-respiratory arrest 35.88 13.80 11 38951 50590 29484975
Artificial crown procedure 35.66 13.80 8 38954 18 29535547
Decreased appetite 35.51 13.80 319 38643 145023 29390542
Jaw fistula 35.50 13.80 9 38953 40 29535525
Metastases to central nervous system 34.91 13.80 45 38917 7086 29528479
Hip fracture 34.80 13.80 55 38907 10437 29525128
Cancer pain 34.61 13.80 27 38935 2320 29533245
Tachycardia 34.38 13.80 27 38935 72383 29463182
Drug hypersensitivity 33.12 13.80 25 38937 68381 29467184
Respiratory failure 32.98 13.80 48 38914 97083 29438482
Prostate cancer recurrent 31.87 13.80 18 38944 897 29534668
Chest pain 31.87 13.80 62 38900 111911 29423654
Stress fracture 31.57 13.80 17 38945 771 29534794
Hospice care 31.34 13.80 36 38926 5032 29530533
Coma 30.97 13.80 7 38955 39443 29496122
Spinal pain 30.84 13.80 35 38927 4829 29530736
International normalised ratio increased 30.83 13.80 10 38952 44362 29491203
Gingival disorder 30.79 13.80 20 38942 1286 29534279
Seizure 30.66 13.80 47 38915 93076 29442489
Palliative care 30.51 13.80 14 38948 448 29535117
Failure to anastomose 29.54 13.80 11 38951 204 29535361
Blood calcium increased 29.10 13.80 28 38934 3191 29532374
Sequestrectomy 28.82 13.80 11 38951 219 29535346
Dental fistula 28.39 13.80 9 38953 100 29535465
Metastases to soft tissue 28.36 13.80 11 38951 229 29535336
Metastases to spine 27.77 13.80 23 38939 2153 29533412
Suicidal ideation 27.57 13.80 6 38956 34710 29500855
Atypical fracture 27.03 13.80 9 38953 118 29535447
Periodontitis 27.00 13.80 21 38941 1796 29533769
Carbohydrate antigen 15-3 increased 26.94 13.80 8 38954 70 29535495
Hyperparathyroidism 25.80 13.80 17 38945 1120 29534445
Febrile neutropenia 25.60 13.80 70 38892 112170 29423395
Gingivitis 25.48 13.80 25 38937 2917 29532648
Lumbar vertebral fracture 25.14 13.80 20 38942 1768 29533797
Metastases to liver 24.99 13.80 51 38911 11805 29523760
Neoplasm progression 24.89 13.80 67 38895 18545 29517020
Arthralgia 24.76 13.80 287 38675 139330 29396235
Aggression 24.71 13.80 8 38954 35533 29500032
Bone disorder 24.48 13.80 34 38928 5749 29529816
Blood glucose increased 24.39 13.80 25 38937 58959 29476606
Disease progression 24.35 13.80 188 38774 81728 29453837
Hypoglycaemia 24.27 13.80 17 38945 48329 29487236
Myocardial infarction 24.26 13.80 70 38892 110226 29425339
Septic shock 24.23 13.80 28 38934 62532 29473033
Tooth infection 24.10 13.80 33 38929 5506 29530059
Gingival swelling 23.40 13.80 16 38946 1121 29534444
Inappropriate schedule of product administration 23.25 13.80 118 38844 44354 29491211
Mastication disorder 23.11 13.80 16 38946 1144 29534421
Bone loss 22.77 13.80 12 38950 521 29535044
Confusional state 22.76 13.80 89 38873 127788 29407777
Multiple organ dysfunction syndrome 22.60 13.80 30 38932 63086 29472479
Bone giant cell tumour malignant 22.53 13.80 4 38958 0 29535565
Osteonecrosis of external auditory canal 22.53 13.80 4 38958 0 29535565
Peri-implantitis 22.53 13.80 4 38958 0 29535565
Lactic acidosis 22.50 13.80 6 38956 30241 29505324
Pseudarthrosis 22.48 13.80 7 38955 73 29535492
Nephrocalcinosis 22.39 13.80 12 38950 539 29535026
Abdominal pain 21.74 13.80 98 38864 135259 29400306
Alanine aminotransferase increased 21.30 13.80 38 38924 70906 29464659
Parathyroid tumour malignant 21.26 13.80 5 38957 15 29535550
Suture rupture 21.20 13.80 10 38952 341 29535224
Respiratory distress 20.99 13.80 8 38954 32098 29503467
Macroenzyme creatine kinase 20.78 13.80 5 38957 17 29535548
Prostatic specific antigen decreased 20.67 13.80 7 38955 97 29535468
Limbic encephalitis 20.65 13.80 10 38952 362 29535203
Gingival abscess 20.61 13.80 8 38954 167 29535398
Coronary artery disease 20.31 13.80 17 38945 44173 29491392
Bone formation increased 20.30 13.80 4 38958 3 29535562
Spinal compression fracture 20.28 13.80 32 38930 6062 29529503
Bone lesion 19.82 13.80 21 38941 2683 29532882
Blood bilirubin increased 19.70 13.80 10 38952 33883 29501682
Weight increased 19.66 13.80 45 38917 76622 29458943
Dental restoration failure 19.58 13.80 5 38957 23 29535542
Psoriasis 19.51 13.80 9 38953 32218 29503347
Depression 19.48 13.80 53 38909 85094 29450471
Respiratory arrest 19.45 13.80 5 38957 25828 29509737
Metabolic acidosis 19.22 13.80 13 38949 37649 29497916
Product use in unapproved indication 19.19 13.80 55 38907 86820 29448745
Abscess oral 19.19 13.80 9 38953 303 29535262
Cough 19.03 13.80 94 38868 126633 29408932
Tremor 18.99 13.80 43 38919 73495 29462070
Extraskeletal ossification 18.77 13.80 5 38957 28 29535537
Hungry bone syndrome 18.66 13.80 6 38956 70 29535495
Shock 18.48 13.80 3 38959 21401 29514164
Blood urea increased 18.39 13.80 7 38955 28105 29507460
Abnormal behaviour 18.36 13.80 4 38958 23123 29512442
Dysgeusia 17.83 13.80 68 38894 22606 29512959
Pain 17.47 13.80 320 38642 171112 29364453
Eosinophilia 17.25 13.80 4 38958 22157 29513408
Calcium ionised abnormal 16.90 13.80 3 38959 0 29535565
Product use issue 16.89 13.80 26 38936 51418 29484147
Gingival pain 16.81 13.80 17 38945 2057 29533508
Vipoma 16.76 13.80 4 38958 13 29535552
Postrenal failure 16.56 13.80 9 38953 416 29535149
Jaw fracture 16.53 13.80 12 38950 925 29534640
Living in residential institution 16.51 13.80 8 38954 290 29535275
Oxygen saturation decreased 16.46 13.80 21 38941 44916 29490649
Bedridden 16.33 13.80 21 38941 3297 29532268
Haematemesis 16.33 13.80 6 38956 24620 29510945
Angioedema 16.31 13.80 11 38951 31904 29503661
Wheezing 16.27 13.80 12 38950 33228 29502337
Pyrexia 16.23 13.80 274 38688 287348 29248217
Acute respiratory distress syndrome 16.23 13.80 5 38957 22930 29512635
Headache 16.13 13.80 149 38813 173858 29361707
Blood creatine phosphokinase increased 15.94 13.80 18 38944 40626 29494939
Blood pressure decreased 15.89 13.80 22 38940 45455 29490110
Hyperaesthesia 15.60 13.80 21 38941 3448 29532117
Asthma 15.58 13.80 13 38949 33836 29501729
Cystitis 15.53 13.80 34 38928 8258 29527307
Anxiety 15.44 13.80 59 38903 85306 29450259
Vitamin D increased 15.35 13.80 5 38957 61 29535504
Hallucination 15.26 13.80 22 38940 44690 29490875
Neoplasm malignant 15.20 13.80 53 38909 16872 29518693
Paraesthesia 15.12 13.80 122 38840 53723 29481842
Dental operation 14.87 13.80 8 38954 362 29535203
Cytomegalovirus infection 14.82 13.80 6 38956 23209 29512356
Bone fistula 14.64 13.80 4 38958 25 29535540
Lung cyst 14.64 13.80 4 38958 25 29535540
Tibia fracture 14.64 13.80 13 38949 1337 29534228
Pulpitis dental 14.57 13.80 8 38954 377 29535188
Oral cavity fistula 14.56 13.80 6 38956 147 29535418
Noninfective gingivitis 14.46 13.80 7 38955 253 29535312
Hypersensitivity 14.43 13.80 30 38932 52873 29482692
Chest discomfort 14.38 13.80 24 38938 45959 29489606
Traumatic fracture 14.36 13.80 7 38955 257 29535308
Poor peripheral circulation 14.28 13.80 13 38949 1381 29534184
Bone giant cell tumour 14.25 13.80 4 38958 28 29535537
Sepsis 14.18 13.80 120 38842 142562 29393003
Acetabulum fracture 14.12 13.80 7 38955 267 29535298
Cardiogenic shock 13.91 13.80 4 38958 19186 29516379
Sedation 13.83 13.80 3 38959 17402 29518163

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 29352.89 11.44 19852 175284 612954 63690642
Osteonecrosis of jaw 13019.75 11.44 4788 190348 35037 64268559
Death 5981.53 11.44 7291 187845 475414 63828182
Hypocalcaemia 2248.96 11.44 1462 193674 40291 64263305
Bone pain 1726.11 11.44 1308 193828 46264 64257332
Tooth disorder 1689.13 11.44 973 194163 21429 64282167
Spinal fracture 1392.26 11.44 750 194386 14424 64289172
Pain in jaw 1318.08 11.44 1047 194089 39708 64263888
Tooth extraction 1267.95 11.44 607 194529 8994 64294602
Atypical femur fracture 1241.81 11.44 485 194651 4213 64299383
Back pain 1226.65 11.44 2479 192657 247692 64055904
Pain in extremity 1064.64 11.44 2629 192507 300456 64003140
Drug ineffective 872.68 11.44 760 194376 839487 63464109
Arthralgia 858.36 11.44 3109 192027 439151 63864445
Bone density abnormal 820.66 11.44 310 194826 2435 64301161
Toxicity to various agents 787.13 11.44 90 195046 363423 63940173
Tooth fracture 705.19 11.44 415 194721 9512 64294084
Thoracic vertebral fracture 684.87 11.44 315 194821 4238 64299358
Myalgia 684.08 11.44 1493 193643 157124 64146472
Completed suicide 645.74 11.44 6 195130 224408 64079188
Metastases to bone 645.46 11.44 518 194618 19917 64283679
Toothache 637.01 11.44 482 194654 16977 64286619
Terminal state 632.81 11.44 296 194840 4148 64299448
Exposed bone in jaw 603.21 11.44 266 194870 3221 64300375
Lumbar vertebral fracture 601.76 11.44 306 194830 5196 64298400
Rebound effect 586.41 11.44 290 194846 4627 64298969
Drug interaction 580.00 11.44 187 194949 361896 63941700
Bone density decreased 578.60 11.44 366 194770 9586 64294010
Jaw disorder 499.76 11.44 255 194881 4362 64299234
Hospitalisation 481.70 11.44 837 194299 74370 64229226
Acute kidney injury 462.51 11.44 408 194728 448832 63854764
Femur fracture 447.12 11.44 534 194602 33601 64269995
Spinal compression fracture 423.48 11.44 354 194782 14421 64289175
Investigation 419.50 11.44 181 194955 2071 64301525
Blood parathyroid hormone increased 419.37 11.44 200 194936 2934 64300662
Dental implantation 406.77 11.44 116 195020 312 64303284
Groin pain 399.01 11.44 307 194829 11086 64292510
Tooth loss 396.63 11.44 243 194893 6004 64297592
Drug abuse 383.21 11.44 3 195133 132371 64171225
Osteomyelitis 376.90 11.44 441 194695 27146 64276450
Pathological fracture 376.67 11.44 270 194866 8735 64294861
Hypotension 368.34 11.44 366 194770 380608 63922988
Loose tooth 355.69 11.44 175 194961 2759 64300837
Musculoskeletal pain 350.86 11.44 766 194370 80528 64223068
Hip fracture 335.43 11.44 412 194724 26687 64276909
Condition aggravated 334.06 11.44 381 194755 372045 63931551
Bone loss 305.15 11.44 143 194993 2012 64301584
Breast cancer metastatic 295.38 11.44 213 194923 6956 64296640
Overdose 293.96 11.44 62 195074 159504 64144092
Blood calcium decreased 288.39 11.44 371 194765 25183 64278413
Dental care 285.86 11.44 101 195035 640 64302956
Dental caries 281.38 11.44 245 194891 10555 64293041
Fracture 259.82 11.44 302 194834 18453 64285143
Bone disorder 256.17 11.44 284 194852 16475 64287121
Intentional overdose 255.78 11.44 3 195133 89941 64213655
Neoplasm progression 254.48 11.44 450 194686 40514 64263082
Infusion related reaction 252.41 11.44 91 195045 164376 64139220
Mobility decreased 243.44 11.44 689 194447 85151 64218445
Cardiac arrest 238.54 11.44 84 195052 153980 64149616
Jaw operation 235.17 11.44 88 195048 671 64302925
Incorrect route of product administration 230.25 11.44 317 194819 22981 64280615
Product use in unapproved indication 226.73 11.44 126 195010 176492 64127104
Drug intolerance 226.04 11.44 145 194991 187847 64115749
Accidental exposure to product 224.25 11.44 334 194802 26030 64277566
Foot fracture 222.99 11.44 275 194861 17882 64285714
Muscle spasms 221.19 11.44 929 194207 140094 64163502
Blood calcium increased 218.96 11.44 192 194944 8350 64295246
Metastases to liver 217.67 11.44 313 194823 23628 64279968
Endodontic procedure 216.29 11.44 116 195020 2207 64301389
Exposure during pregnancy 214.84 11.44 4 195132 77671 64225925
Exostosis of jaw 212.72 11.44 93 195043 1101 64302495
Maternal exposure during pregnancy 211.53 11.44 22 195114 95862 64207734
Synovitis 207.99 11.44 27 195109 99063 64204533
Treatment failure 207.84 11.44 49 195087 116767 64186829
Drug hypersensitivity 203.68 11.44 252 194884 237563 64066033
Contraindicated product administered 200.40 11.44 41 195095 107788 64195808
Confusional state 200.19 11.44 300 194836 260844 64042752
Bradycardia 199.92 11.44 55 195081 118164 64185432
Tooth abscess 190.45 11.44 222 194914 13604 64289992
Product use issue 187.92 11.44 113 195023 151602 64151994
Prostatic specific antigen increased 183.77 11.44 176 194960 8584 64295012
Gingival pain 183.36 11.44 153 194983 6214 64297382
Somnolence 178.36 11.44 212 194924 203433 64100163
Osteitis 178.20 11.44 120 195016 3502 64300094
Cardio-respiratory arrest 175.57 11.44 41 195095 98352 64205244
Suicide attempt 171.24 11.44 11 195125 70996 64232600
Gingival disorder 169.83 11.44 113 195023 3231 64300365
Spinal pain 167.78 11.44 199 194937 12422 64291174
Tachycardia 164.43 11.44 127 195009 149452 64154144
Temporomandibular joint syndrome 163.71 11.44 111 195025 3277 64300319
Seizure 163.66 11.44 158 194978 166734 64136862
Gastrointestinal haemorrhage 163.22 11.44 99 195037 132213 64171383
Dyspnoea 163.10 11.44 1392 193744 717282 63586314
Tetany 162.69 11.44 94 195042 2078 64301518
Abscess jaw 161.85 11.44 85 195051 1547 64302049
Gingivitis 160.90 11.44 154 194982 7505 64296091
Cystitis 159.48 11.44 380 194756 42295 64261301
Coma 159.35 11.44 35 195101 87580 64216016
Febrile neutropenia 157.34 11.44 202 194934 187455 64116141
Malignant neoplasm progression 155.96 11.44 716 194420 112155 64191441
Vomiting 155.73 11.44 1003 194133 550114 63753482
Hepatic enzyme increased 155.09 11.44 101 195035 129842 64173754
Pemphigus 153.86 11.44 7 195129 60694 64242902
Compression fracture 152.90 11.44 132 195004 5620 64297976
Product storage error 152.84 11.44 195 194941 13123 64290473
Hypoglycaemia 151.64 11.44 42 195094 89850 64213746
Stress fracture 151.40 11.44 130 195006 5494 64298102
Therapeutic product effect decreased 149.86 11.44 81 195055 115270 64188326
Lactic acidosis 149.63 11.44 9 195127 61401 64242195
Respiratory failure 147.40 11.44 162 194974 161021 64142575
Pyrexia 145.24 11.44 1042 194094 557602 63745994
Wrist fracture 145.18 11.44 165 194971 9836 64293760
Osteonecrosis 145.17 11.44 286 194850 27943 64275653
Eczema 144.33 11.44 294 194842 29426 64274170
Blood calcium abnormal 143.72 11.44 72 195064 1182 64302414
International normalised ratio increased 143.21 11.44 32 195104 79135 64224461
Sequestrectomy 141.16 11.44 63 195073 786 64302810
Agitation 140.52 11.44 46 195090 88321 64215275
Tooth infection 140.27 11.44 196 194940 14405 64289191
Hypercalcaemia 137.68 11.44 298 194838 31118 64272478
Hyperaesthesia teeth 137.30 11.44 75 195061 1482 64302114
Multiple organ dysfunction syndrome 136.51 11.44 68 195068 101345 64202251
Lower limb fracture 136.39 11.44 186 194950 13359 64290237
Artificial crown procedure 135.38 11.44 44 195092 207 64303389
Breast cancer 134.10 11.44 282 194854 28866 64274730
Hypophosphataemia 133.15 11.44 192 194944 14528 64289068
Dental restoration failure 131.82 11.44 54 195082 537 64303059
Gingival recession 131.35 11.44 65 195071 1038 64302558
Periodontitis 130.38 11.44 105 195031 4054 64299542
Multiple fractures 127.93 11.44 122 195014 5918 64297678
Pelvic fracture 126.51 11.44 158 194978 10405 64293191
Metastases to lung 126.40 11.44 191 194945 15073 64288523
Atypical fracture 126.38 11.44 54 195082 602 64302994
Pneumonia 124.86 11.44 1088 194048 558488 63745108
Depressed level of consciousness 121.61 11.44 47 195089 81389 64222207
Gingival swelling 120.84 11.44 98 195038 3822 64299774
Metabolic acidosis 119.97 11.44 33 195103 70925 64232671
Oxygen saturation decreased 119.04 11.44 90 195046 107086 64196510
Suicidal ideation 118.16 11.44 28 195108 66514 64237082
Alanine aminotransferase increased 117.19 11.44 149 194987 138882 64164714
Pain 116.63 11.44 2334 192802 551177 63752419
Musculoskeletal discomfort 115.84 11.44 190 194946 16087 64287509
Systemic lupus erythematosus 115.56 11.44 45 195091 77567 64226029
Impaired healing 115.47 11.44 424 194712 60049 64243547
Unresponsive to stimuli 115.27 11.44 10 195126 50383 64253213
Intentional product use issue 113.94 11.44 74 195062 95290 64208306
Carbohydrate antigen 15-3 increased 111.15 11.44 56 195080 931 64302665
Hyponatraemia 110.12 11.44 174 194962 148165 64155431
Respiratory arrest 109.82 11.44 15 195121 52970 64250626
Joint swelling 109.41 11.44 313 194823 215069 64088527
Abdominal pain 107.81 11.44 532 194604 311843 63991753
Paraesthesia 107.31 11.44 736 194400 133786 64169810
Vitamin D decreased 106.82 11.44 124 195012 7563 64296033
Metastases to lymph nodes 105.38 11.44 131 195005 8586 64295010
Inappropriate schedule of product administration 105.01 11.44 554 194582 91732 64211864
Rib fracture 104.17 11.44 227 194909 23811 64279785
Rash pruritic 102.56 11.44 394 194742 57010 64246586
Serotonin syndrome 101.31 11.44 4 195132 39278 64264318
Hypoxia 100.51 11.44 72 195064 88077 64215519
Occupational exposure to product 100.01 11.44 45 195091 573 64303023
Renal failure 99.05 11.44 255 194881 181433 64122163
Osteonecrosis of external auditory canal 98.88 11.44 29 195107 89 64303507
Mastication disorder 98.72 11.44 71 195065 2308 64301288
Pericarditis 98.58 11.44 33 195103 62483 64241113
Syncope 96.50 11.44 208 194928 157427 64146169
Rhabdomyolysis 95.64 11.44 82 195054 91644 64211952
Sleep disorder due to a general medical condition 95.17 11.44 121 195015 8113 64295483
Encephalopathy 94.60 11.44 30 195106 58789 64244807
Upper limb fracture 94.48 11.44 165 194971 14701 64288895
Hyperkalaemia 94.24 11.44 100 195036 101029 64202567
Product dose omission issue 93.35 11.44 950 194186 193797 64109799
Blood pressure decreased 92.41 11.44 75 195061 86124 64217472
Septic shock 91.99 11.44 110 195026 105327 64198269
Bedridden 91.64 11.44 132 195004 9977 64293619
Tumour marker increased 91.35 11.44 79 195057 3371 64300225
Sepsis 91.01 11.44 373 194763 229968 64073628
Weight increased 90.35 11.44 336 194800 213012 64090584
Pancytopenia 89.47 11.44 187 194949 143122 64160474
Fall 89.42 11.44 1763 193373 415063 63888533
Neoplasm malignant 88.12 11.44 216 194920 24472 64279124
Aspartate aminotransferase increased 87.49 11.44 142 194994 119646 64183950
Drug reaction with eosinophilia and systemic symptoms 86.58 11.44 28 195108 54189 64249407
Hospice care 86.48 11.44 111 195025 7514 64296082
Helicobacter infection 84.08 11.44 9 195127 38353 64265243
Anaphylactic reaction 83.78 11.44 52 195084 68612 64234984
Toxic epidermal necrolysis 83.33 11.44 8 195128 37158 64266438
Aggression 82.98 11.44 19 195117 46213 64257383
Metastases to central nervous system 82.74 11.44 150 194986 13762 64289834
Prostate cancer metastatic 82.15 11.44 73 195063 3231 64300365
Dental operation 81.58 11.44 45 195091 907 64302689
Gait disturbance 80.68 11.44 836 194300 171319 64132277
Drug level increased 80.40 11.44 6 195130 34190 64269406
Multiple sclerosis relapse 79.89 11.44 14 195122 41121 64262475
Duodenal ulcer perforation 78.84 11.44 7 195129 34618 64268978
Blood creatine phosphokinase increased 77.68 11.44 40 195096 58518 64245078
Dry skin 76.22 11.44 332 194804 50829 64252767
Psychotic disorder 76.07 11.44 8 195128 34570 64269026
Dental fistula 76.07 11.44 35 195101 471 64303125
Hand deformity 75.94 11.44 48 195088 62723 64240873
Gingival abscess 75.39 11.44 39 195097 687 64302909
Femoral neck fracture 74.85 11.44 111 195025 8613 64294983
Intentional self-injury 74.76 11.44 3 195133 29041 64274555
Jaw fistula 74.35 11.44 23 195113 89 64303507
Loss of consciousness 74.28 11.44 217 194919 148148 64155448
Coronary artery disease 73.41 11.44 46 195090 60387 64243209
Wound 73.08 11.44 74 195062 76403 64227193
Hyperparathyroidism 72.88 11.44 64 195072 2788 64300808
Fractured sacrum 72.88 11.44 49 195087 1426 64302170
Myocardial infarction 71.60 11.44 259 194877 165562 64138034
Tooth erosion 71.13 11.44 31 195105 364 64303232
Chest pain 70.80 11.44 421 194715 235559 64068037
Body height decreased 70.47 11.44 100 195036 7454 64296142
Metastases to spine 70.44 11.44 70 195066 3573 64300023
Wheezing 70.35 11.44 84 195052 80495 64223101
Joint noise 70.18 11.44 66 195070 3145 64300451
Hallucination 70.05 11.44 70 195066 72718 64230878
Sciatica 69.90 11.44 175 194961 20089 64283507
Orthostatic hypotension 69.73 11.44 27 195109 46711 64256885
Neck pain 69.71 11.44 369 194767 61164 64242432
Eosinophilia 69.64 11.44 15 195121 38061 64265535
Rheumatoid arthritis 68.72 11.44 260 194876 164034 64139562
Mental status changes 68.36 11.44 51 195085 61111 64242485
Pulpitis dental 68.18 11.44 41 195095 978 64302618
Hot flush 67.32 11.44 298 194838 45937 64257659
Influenza like illness 67.17 11.44 366 194770 61336 64242260
Chest discomfort 65.54 11.44 160 194976 115946 64187650
Cytomegalovirus infection 65.36 11.44 16 195120 37183 64266413
Sedation 65.17 11.44 22 195114 41440 64262156
Tibia fracture 65.03 11.44 76 195060 4669 64298927
Oral pain 64.04 11.44 206 194930 27287 64276309
Folliculitis 63.56 11.44 8 195128 30069 64273527
Dysarthria 63.28 11.44 52 195084 59354 64244242
Psoriatic arthropathy 62.94 11.44 26 195110 43255 64260341
Delirium 62.71 11.44 70 195066 69124 64234472
Incorrect dose administered 62.51 11.44 55 195081 60710 64242886
Glossodynia 62.50 11.44 62 195074 64634 64238962
Haematemesis 62.50 11.44 32 195104 46967 64256629
Drug withdrawal syndrome 62.21 11.44 10 195126 31281 64272315
C-telopeptide increased 61.60 11.44 14 195122 7 64303589
Dermatitis 61.45 11.44 155 194981 17874 64285722
Generalised tonic-clonic seizure 61.18 11.44 22 195114 39835 64263761
Abortion spontaneous 60.30 11.44 4 195132 25139 64278457
Heart rate decreased 60.16 11.44 47 195089 55020 64248576
Scoliosis 58.95 11.44 82 195054 6000 64297596
Acute respiratory distress syndrome 58.91 11.44 22 195114 38913 64264683
Humerus fracture 58.77 11.44 94 195042 7791 64295805
Metastasis 58.54 11.44 79 195057 5616 64297980
Muscle injury 58.46 11.44 6 195130 26431 64277165
Dental necrosis 58.40 11.44 21 195115 141 64303455
Walking aid user 58.38 11.44 83 195053 6198 64297398
Dental cleaning 58.10 11.44 14 195122 13 64303583
Respiratory distress 58.02 11.44 44 195092 52287 64251309
Ear pain 57.33 11.44 187 194949 24949 64278647
Dehydration 57.23 11.44 402 194734 216361 64087235
Bone lesion 57.03 11.44 74 195062 5063 64298533
Emotional distress 56.85 11.44 19 195117 36019 64267577
Thrombocytopenia 56.21 11.44 421 194715 223380 64080216
Adverse drug reaction 55.92 11.44 279 194857 45185 64258411
Cardiac failure congestive 55.67 11.44 205 194931 130375 64173221
Headache 55.09 11.44 1202 193934 528265 63775331
Labelled drug-drug interaction medication error 54.45 11.44 3 195133 22059 64281537
Tremor 54.25 11.44 247 194889 147983 64155613
C-reactive protein abnormal 54.04 11.44 11 195125 29036 64274560
Oedema 54.03 11.44 124 195012 91811 64211785
Blood glucose increased 53.91 11.44 137 194999 97936 64205660
Ventricular fibrillation 53.85 11.44 5 195131 23855 64279741
Atrial fibrillation 53.56 11.44 301 194835 170788 64132808
Blood bilirubin increased 53.51 11.44 57 195079 57496 64246100
Living in residential institution 53.13 11.44 29 195107 572 64303024
Drug-induced liver injury 52.89 11.44 40 195096 47603 64255993
Nausea 52.32 11.44 1899 193237 783901 63519695
Blood creatinine increased 52.27 11.44 222 194914 135560 64168036
Device expulsion 51.78 11.44 3 195133 21133 64282463
Liver function test abnormal 51.77 11.44 62 195074 59339 64244257
Intentional product misuse 51.56 11.44 87 195049 72208 64231388
Acute myocardial infarction 51.50 11.44 82 195054 69636 64233960
Cardiogenic shock 51.32 11.44 17 195119 32410 64271186
Circulatory collapse 51.13 11.44 19 195117 33713 64269883
Musculoskeletal chest pain 50.99 11.44 162 194974 21317 64282279
Poisoning 50.98 11.44 4 195132 21875 64281721
Tooth resorption 50.80 11.44 13 195123 19 64303577
Ventricular tachycardia 50.78 11.44 20 195116 34245 64269351
Stevens-Johnson syndrome 50.74 11.44 20 195116 34229 64269367
Sinus tachycardia 50.73 11.44 17 195119 32171 64271425
Parathyroid disorder 50.36 11.44 25 195111 402 64303194
Angioedema 50.27 11.44 68 195068 61753 64241843
Denture wearer 50.16 11.44 16 195120 70 64303526
Haematochezia 50.04 11.44 77 195059 66296 64237300
Alopecia 50.04 11.44 741 194395 164949 64138647
Product prescribing error 49.98 11.44 22 195114 35247 64268349
Dental discomfort 49.89 11.44 23 195113 311 64303285
Haemoglobin decreased 49.42 11.44 366 194770 194697 64108899
White blood cell count increased 49.37 11.44 77 195059 65937 64237659
Lower respiratory tract infection 49.09 11.44 136 195000 94478 64209118
Renal tubular necrosis 48.93 11.44 5 195131 22105 64281491
Drug dependence 48.46 11.44 20 195116 33292 64270304
Hypersensitivity 48.17 11.44 372 194764 196080 64107516
Arthritis 48.13 11.44 425 194711 83389 64220207
Pulmonary oedema 47.96 11.44 104 195032 78570 64225026
Vitamin D abnormal 47.68 11.44 17 195119 111 64303485
Abnormal behaviour 47.61 11.44 21 195115 33601 64269995
Blood pressure increased 47.02 11.44 317 194819 172235 64131361
Anxiety 46.80 11.44 390 194746 202259 64101337
Blood phosphorus decreased 46.68 11.44 71 195065 5634 64297962
Shock 46.59 11.44 29 195107 38211 64265385
Hypoaesthesia 46.35 11.44 633 194503 138475 64165121
Osteoporosis 46.06 11.44 250 194886 41830 64261766
Jaw fracture 45.86 11.44 49 195087 2725 64300871
Respiratory depression 45.48 11.44 8 195128 23435 64280161
Status epilepticus 45.20 11.44 6 195130 21657 64281939
Coagulopathy 45.10 11.44 20 195116 31900 64271696
Drug ineffective for unapproved indication 44.79 11.44 19 195117 31114 64272482
Oral cavity fistula 44.72 11.44 27 195109 649 64302947
Polymyalgia rheumatica 44.70 11.44 53 195083 3306 64300290
Hand fracture 44.70 11.44 64 195072 4810 64298786
Right ventricular failure 44.68 11.44 6 195130 21465 64282131
Extrapyramidal disorder 44.39 11.44 4 195132 19548 64284048
Blood pressure fluctuation 44.29 11.44 55 195081 51816 64251780
Spinal operation 44.19 11.44 72 195064 6061 64297535
Hypervolaemia 43.99 11.44 31 195105 38254 64265342
Spinal deformity 43.80 11.44 29 195107 822 64302774
Medication error 43.70 11.44 52 195084 49914 64253682
Hyperparathyroidism secondary 43.63 11.44 44 195092 2286 64301310
Haematocrit decreased 43.55 11.44 61 195075 54594 64249002
Bronchopulmonary aspergillosis 43.07 11.44 4 195132 19081 64284515
Accidental overdose 42.93 11.44 24 195112 33533 64270063
Cytokine release syndrome 42.92 11.44 6 195130 20823 64282773
Hyperhidrosis 42.87 11.44 213 194923 124707 64178889
Agranulocytosis 42.56 11.44 32 195104 38197 64265399
Pulmonary arterial hypertension 42.49 11.44 12 195124 25355 64278241
C-reactive protein increased 42.44 11.44 146 194990 94763 64208833
Mouth swelling 42.42 11.44 64 195072 5043 64298553
Pancreatitis 42.26 11.44 72 195064 59535 64244061
Heart rate increased 41.99 11.44 155 194981 98520 64205076
Radius fracture 41.98 11.44 50 195086 3134 64300462
Tachypnoea 41.93 11.44 14 195122 26557 64277039
Blood parathyroid hormone abnormal 41.90 11.44 21 195115 345 64303251
Liver injury 41.90 11.44 19 195117 29913 64273683
Palliative care 41.80 11.44 26 195110 660 64302936
Hemiparesis 41.65 11.44 19 195117 29808 64273788
Osteoarthritis 41.60 11.44 331 194805 63005 64240591
Flushing 41.59 11.44 112 195024 78536 64225060
Product quality issue 41.58 11.44 19 195117 29780 64273816
Dyskinesia 41.30 11.44 35 195101 39353 64264243
Oral infection 41.30 11.44 61 195075 4716 64298880
Pneumocystis jirovecii pneumonia 41.16 11.44 16 195120 27618 64275978
Abdominal discomfort 41.14 11.44 353 194783 181969 64121627
Deep vein thrombosis 41.07 11.44 171 194965 105011 64198585
Transplant rejection 41.06 11.44 3 195133 17398 64286198
Torsade de pointes 40.95 11.44 3 195133 17360 64286236
Bone marrow failure 40.78 11.44 51 195085 47901 64255695
Acute myeloid leukaemia 40.74 11.44 16 195120 27447 64276149
Haematoma 40.59 11.44 48 195088 46202 64257394
Melaena 40.48 11.44 62 195074 53486 64250110
Parathyroidectomy 40.31 11.44 17 195119 183 64303413
Injury 40.28 11.44 67 195069 55925 64247671
No adverse event 40.18 11.44 18 195118 28543 64275053
Noninfective gingivitis 39.95 11.44 33 195103 1321 64302275
Therapeutic response decreased 39.86 11.44 60 195076 52128 64251468
Staphylococcal infection 38.96 11.44 58 195078 50620 64252976
Feeling abnormal 38.96 11.44 594 194542 133008 64170588
Injection site erythema 38.83 11.44 99 195037 70701 64232895
Paraesthesia oral 38.75 11.44 107 195029 13024 64290572
Bone swelling 38.73 11.44 31 195105 1186 64302410
Fluid retention 38.69 11.44 76 195060 59530 64244066
Hormone-refractory prostate cancer 38.68 11.44 20 195116 352 64303244
Osteoporotic fracture 38.65 11.44 51 195085 3547 64300049
Infection 38.63 11.44 365 194771 184515 64119081
Diarrhoea 38.35 11.44 1792 193344 720912 63582684
Hepatic failure 38.28 11.44 68 195068 55326 64248270
Tubulointerstitial nephritis 38.27 11.44 23 195113 30886 64272710
Oral surgery 38.22 11.44 28 195108 937 64302659
Disorientation 38.16 11.44 69 195067 55759 64247837
Aspergillus infection 38.15 11.44 3 195133 16376 64287220
Cyanosis 38.01 11.44 10 195126 22145 64281451
Red blood cell sedimentation rate abnormal 37.94 11.44 3 195133 16303 64287293
Oedema peripheral 37.90 11.44 430 194706 209887 64093709
Nerve compression 37.64 11.44 75 195061 7386 64296210
Blood urea increased 37.51 11.44 47 195089 44106 64259490
Psoriasis 37.25 11.44 103 195033 71600 64231996
Diabetic ketoacidosis 37.24 11.44 22 195114 29823 64273773
Type 2 diabetes mellitus 37.21 11.44 29 195107 33991 64269605
Hallucination, auditory 37.05 11.44 4 195132 16935 64286661
Acute respiratory failure 36.62 11.44 59 195077 49875 64253721
Pulmonary hypertension 36.56 11.44 46 195090 43093 64260503
Restlessness 36.32 11.44 40 195096 39745 64263851
Injection site reaction 36.27 11.44 53 195083 46611 64256985
Respiratory rate increased 36.12 11.44 6 195130 18325 64285271
Adverse reaction 36.08 11.44 75 195061 7612 64295984
Bone graft 36.06 11.44 23 195113 611 64302985
Onychoclasis 35.96 11.44 56 195080 4536 64299060
Metastases to skin 35.94 11.44 32 195104 1420 64302176
Device failure 35.94 11.44 63 195073 5629 64297967
Jaundice 35.88 11.44 57 195079 48455 64255141
Pneumonia aspiration 35.59 11.44 79 195057 59192 64244404
Disease recurrence 35.56 11.44 26 195110 31484 64272112
Leukocytosis 35.50 11.44 37 195099 37703 64265893
Renal injury 35.45 11.44 3 195133 15426 64288170
Menopausal symptoms 35.36 11.44 33 195103 1557 64302039
Obstructive airways disorder 35.24 11.44 13 195123 23172 64280424
Vitamin D deficiency 35.23 11.44 96 195040 11596 64292000
Cancer pain 34.86 11.44 53 195083 4204 64299392
PIK3CA-activated mutation 34.81 11.44 21 195115 504 64303092
Asthma 34.63 11.44 159 194977 95066 64208530
Musculoskeletal disorder 34.54 11.44 126 195010 17780 64285816
Withdrawal syndrome 34.34 11.44 14 195122 23478 64280118
Ataxia 34.22 11.44 12 195124 22072 64281524
Hallucination, visual 34.06 11.44 21 195115 27813 64275783
Hypothermia 34.00 11.44 9 195127 19847 64283749
Haemodynamic instability 33.99 11.44 3 195133 14909 64288687
Bone giant cell tumour malignant 33.63 11.44 7 195129 0 64303596
Irritability 33.48 11.44 37 195099 36709 64266887
Parathyroid tumour malignant 33.32 11.44 10 195126 34 64303562
Angina pectoris 33.31 11.44 53 195083 45028 64258568
Hepatitis 33.29 11.44 54 195082 45528 64258068
Paranoia 33.02 11.44 5 195131 16347 64287249
Pancreatitis acute 32.99 11.44 49 195087 42806 64260790
Angina unstable 32.96 11.44 4 195132 15463 64288133
Gingival operation 32.66 11.44 11 195125 59 64303537
Premature delivery 32.64 11.44 8 195128 18581 64285015
Upper gastrointestinal haemorrhage 32.60 11.44 35 195101 35185 64268411
Swelling 32.33 11.44 319 194817 159899 64143697
Sinusitis 32.26 11.44 284 194852 145644 64157952
Gingival erythema 32.15 11.44 20 195116 508 64303088
Cataract operation 32.04 11.44 48 195088 3758 64299838
Shock haemorrhagic 31.99 11.44 6 195130 16785 64286811
Cognitive disorder 31.80 11.44 75 195061 55012 64248584
Muscle spasticity 31.66 11.44 6 195130 16663 64286933
Intervertebral disc protrusion 31.58 11.44 133 195003 20058 64283538
Prescribed overdose 31.58 11.44 11 195125 20320 64283276
Lymphoedema 31.53 11.44 83 195053 9822 64293774
Prostate cancer 31.44 11.44 131 195005 19664 64283932
Haemoptysis 31.44 11.44 63 195073 48985 64254611
Hyperglycaemia 31.35 11.44 88 195048 60880 64242716
Cardiac failure 31.34 11.44 253 194883 132120 64171476
Drug resistance 31.27 11.44 36 195100 35066 64268530
Dental prosthesis user 30.84 11.44 9 195127 27 64303569
Hepatocellular injury 30.83 11.44 56 195080 45179 64258417
Pseudomonas infection 30.82 11.44 8 195128 17875 64285721
Haemorrhage intracranial 30.67 11.44 17 195119 23867 64279729
Myoclonus 30.66 11.44 19 195117 25099 64278497
Acidosis 30.59 11.44 8 195128 17787 64285809
Bone fissure 30.58 11.44 13 195123 143 64303453
Mastectomy 30.43 11.44 25 195111 993 64302603
Dental prosthesis placement 30.38 11.44 8 195128 14 64303582
Aphasia 30.31 11.44 48 195088 40858 64262738
Pallor 30.19 11.44 44 195092 38737 64264859
Peri-implantitis 30.13 11.44 9 195127 30 64303566
Intercepted medication error 30.12 11.44 22 195114 733 64302863
Red blood cell sedimentation rate increased 30.09 11.44 30 195106 31205 64272391
Hepatic encephalopathy 30.07 11.44 13 195123 21053 64282543
Periodontal disease 29.97 11.44 31 195105 1660 64301936
Sinus bradycardia 29.82 11.44 16 195120 22877 64280719
Dysstasia 29.64 11.44 144 194992 23071 64280525
Oral discomfort 29.41 11.44 73 195063 8333 64295263
Muscle tightness 29.33 11.44 87 195049 11028 64292568
Delusion 29.30 11.44 9 195127 18005 64285591
Calcinosis 29.19 11.44 33 195103 1955 64301641
Haemorrhage 29.15 11.44 132 195004 79219 64224377
Diabetes mellitus inadequate control 29.12 11.44 14 195122 21307 64282289
Abscess oral 29.10 11.44 26 195110 1159 64302437
Back disorder 29.08 11.44 81 195055 9909 64293687
Acute coronary syndrome 29.06 11.44 11 195125 19299 64284297
Hepatic cytolysis 29.06 11.44 4 195132 14045 64289551
Ulna fracture 28.82 11.44 24 195112 972 64302624
Haemodialysis 28.75 11.44 8 195128 17069 64286527
Weight bearing difficulty 28.56 11.44 38 195098 2665 64300931
Urinary tract infection 28.40 11.44 909 194227 230687 64072909
Hypokalaemia 28.40 11.44 234 194902 121669 64181927
Haemophagocytic lymphohistiocytosis 28.28 11.44 9 195127 17600 64285996
Anuria 28.21 11.44 11 195125 18953 64284643
Hypoaesthesia oral 28.09 11.44 88 195048 11492 64292104
Exostosis 27.82 11.44 87 195049 11351 64292245
Decreased immune responsiveness 27.78 11.44 49 195087 4399 64299197
Altered state of consciousness 27.59 11.44 45 195091 37857 64265739
Rehabilitation therapy 27.52 11.44 28 195108 1470 64302126
Adverse event 27.38 11.44 209 194927 39280 64264316
Metastases to meninges 27.35 11.44 38 195098 2777 64300819
COVID-19 27.27 11.44 103 195033 65037 64238559
Posterior reversible encephalopathy syndrome 27.13 11.44 18 195118 22928 64280668
Cholesteatoma 27.06 11.44 11 195125 107 64303489
Bronchospasm 27.03 11.44 16 195120 21666 64281930
Parathyroid tumour 26.98 11.44 10 195126 74 64303522
Unevaluable event 26.93 11.44 252 194884 50237 64253359
Hyperthermia 26.71 11.44 7 195129 15543 64288053
Depression 26.63 11.44 392 194744 182899 64120697
Hip surgery 26.48 11.44 35 195101 2438 64301158
Hungry bone syndrome 26.45 11.44 12 195124 156 64303440
Forearm fracture 26.44 11.44 17 195119 458 64303138
Acute hepatic failure 26.41 11.44 24 195112 26088 64277508
Dizziness 26.40 11.44 1049 194087 429114 63874482
Device fastener issue 26.32 11.44 7 195129 13 64303583
Ankle fracture 26.29 11.44 101 195035 14609 64288987
Vitamin D increased 26.28 11.44 17 195119 463 64303133
Abdominal lymphadenopathy 26.26 11.44 24 195112 1102 64302494
Osteolysis 25.99 11.44 37 195099 2766 64300830
Kyphosis 25.83 11.44 34 195102 2359 64301237
Photophobia 25.78 11.44 10 195126 17283 64286313
Activated partial thromboplastin time prolonged 25.73 11.44 4 195132 12827 64290769
Metaphyseal corner fracture 25.65 11.44 8 195128 32 64303564
Nightmare 25.46 11.44 16 195120 20977 64282619
Rash macular 25.43 11.44 140 194996 23545 64280051
Adnexa uteri mass 25.39 11.44 14 195122 282 64303314
Subarachnoid haemorrhage 25.35 11.44 12 195124 18426 64285170
Ascites 25.33 11.44 99 195037 61902 64241694
Myocardial ischaemia 25.20 11.44 20 195116 23231 64280365
Brain oedema 25.19 11.44 18 195118 22057 64281539
Pathogen resistance 24.95 11.44 4 195132 12539 64291057
Limb discomfort 24.88 11.44 154 194982 27021 64276575
Progressive multifocal leukoencephalopathy 24.86 11.44 12 195124 18220 64285376
Bone resorption test abnormal 24.68 11.44 6 195130 6 64303590
Immune system disorder 24.55 11.44 72 195064 9069 64294527
Lung neoplasm malignant 24.54 11.44 129 195007 21319 64282277
Device dislocation 24.52 11.44 17 195119 21161 64282435
Rectal haemorrhage 24.44 11.44 100 195036 61717 64241879
Bone formation increased 24.24 11.44 9 195127 67 64303529
Thrombotic microangiopathy 24.22 11.44 10 195126 16645 64286951
Osteocalcin decreased 24.21 11.44 6 195130 7 64303589
Rales 24.07 11.44 8 195128 15221 64288375
Oral neoplasm benign 24.02 11.44 5 195131 0 64303596
Calcium ionised abnormal 24.02 11.44 5 195131 0 64303596
Myelosuppression 23.99 11.44 22 195114 23808 64279788
Therapy non-responder 23.98 11.44 110 195026 65789 64237807
Nasopharyngitis 23.96 11.44 433 194703 195640 64107956
Transaminases increased 23.95 11.44 63 195073 44531 64259065
Rash papular 23.93 11.44 109 195027 17004 64286592
Hepatitis cholestatic 23.90 11.44 4 195132 12151 64291445
Nasal congestion 23.90 11.44 96 195040 59562 64244034
Injection site pruritus 23.89 11.44 49 195087 37777 64265819
Blood cholesterol increased 23.83 11.44 244 194892 49822 64253774
Bone deformity 23.75 11.44 13 195123 258 64303338
Root canal infection 23.66 11.44 13 195123 260 64303336
Anger 23.63 11.44 9 195127 15732 64287864
Bone sequestrum 23.55 11.44 23 195113 1149 64302447
Bacteraemia 23.54 11.44 28 195108 26883 64276713
Bone cancer 23.43 11.44 26 195110 1509 64302087
Gingival injury 23.28 11.44 7 195129 24 64303572
Atelectasis 23.18 11.44 29 195107 27237 64276359
Obesity 23.16 11.44 17 195119 20545 64283051
Proteinuria 23.04 11.44 30 195106 27693 64275903
Basal cell carcinoma 23.02 11.44 36 195100 30802 64272794
Blood alkaline phosphatase decreased 22.92 11.44 26 195110 1546 64302050
Disturbance in attention 22.85 11.44 57 195079 41017 64262579
Bone fistula 22.85 11.44 9 195127 80 64303516
Parathyroid tumour benign 22.82 11.44 18 195118 674 64302922
Subdural haematoma 22.66 11.44 31 195105 28023 64275573
Lower gastrointestinal haemorrhage 22.60 11.44 7 195129 13932 64289664
Haematuria 22.56 11.44 100 195036 60371 64243225
Cerebral haemorrhage 22.56 11.44 79 195057 51011 64252585
Presyncope 22.55 11.44 45 195091 35044 64268552
Dementia 22.47 11.44 123 195013 20643 64282953
Pulmonary haemorrhage 22.33 11.44 6 195130 13103 64290493
Akathisia 22.17 11.44 4 195132 11506 64292090
Hepatic lesion 21.90 11.44 52 195084 5772 64297824
Nephropathy toxic 21.73 11.44 13 195123 17501 64286095
Tartrate-resistant acid phosphatase increased 21.68 11.44 5 195131 3 64303593
Vertebroplasty 21.66 11.44 12 195124 244 64303352
Muscle rigidity 21.63 11.44 13 195123 17460 64286136
Anaemia 21.62 11.44 931 194205 377749 63925847
Gingival ulceration 21.57 11.44 19 195117 831 64302765
Hepatic steatosis 21.48 11.44 38 195098 30969 64272627
Quality of life decreased 21.46 11.44 62 195074 7744 64295852
Heart rate irregular 21.44 11.44 31 195105 27382 64276214
Gamma-glutamyltransferase increased 21.43 11.44 75 195061 48435 64255161
Hypovolaemia 21.41 11.44 10 195126 15476 64288120
Dysgeusia 21.31 11.44 227 194909 46820 64256776
Breast cancer recurrent 20.93 11.44 32 195104 2551 64301045
Trismus 20.91 11.44 46 195090 4855 64298741
Sudden death 20.89 11.44 18 195118 20078 64283518
Inappropriate antidiuretic hormone secretion 20.80 11.44 22 195114 22267 64281329
Cholestasis 20.76 11.44 68 195068 44804 64258792
Pulmonary congestion 20.72 11.44 25 195111 23855 64279741
Hypophosphatasia 20.72 11.44 7 195129 38 64303558
Degenerative bone disease 20.57 11.44 7 195129 39 64303557
Tricuspid valve incompetence 20.56 11.44 13 195123 16990 64286606
Lichen planus 20.52 11.44 30 195106 2298 64301298
Creatinine renal clearance decreased 20.43 11.44 9 195127 14412 64289184
Atrioventricular block complete 20.42 11.44 9 195127 14409 64289187
Acetabulum fracture 20.40 11.44 15 195121 505 64303091
Parkinsonism 20.31 11.44 9 195127 14364 64289232
Traumatic fracture 20.31 11.44 18 195118 794 64302802
Hepatomegaly 20.29 11.44 13 195123 16869 64286727
Pollakiuria 20.27 11.44 164 194972 31366 64272230
Anaphylactic shock 20.26 11.44 38 195098 30290 64273306
Hair disorder 20.16 11.44 19 195117 908 64302688
Neutrophil count increased 20.15 11.44 28 195108 25146 64278450
Drug level decreased 20.10 11.44 5 195131 11498 64292098
Rash maculo-papular 19.91 11.44 74 195062 46952 64256644
Metastases to neck 19.86 11.44 6 195130 21 64303575
Prostate cancer recurrent 19.60 11.44 17 195119 728 64302868
Scab 19.57 11.44 66 195070 8956 64294640
Caesarean section 19.51 11.44 5 195131 11269 64292327
Catheter site injury 19.37 11.44 9 195127 124 64303472
Oliguria 19.26 11.44 10 195126 14566 64289030
Productive cough 19.17 11.44 136 195000 73067 64230529
Lung infiltration 19.07 11.44 21 195115 20868 64282728
Medial tibial stress syndrome 18.99 11.44 9 195127 130 64303466
Triple negative breast cancer 18.98 11.44 8 195128 86 64303510
Mitral valve incompetence 18.89 11.44 30 195106 25508 64278088
Coordination abnormal 18.71 11.44 11 195125 14953 64288643
Bradyphrenia 18.71 11.44 3 195133 9403 64294193
Oligodipsia 18.50 11.44 6 195130 28 64303568
Bone marrow oedema 18.46 11.44 20 195116 1130 64302466
Cholecystitis chronic 18.39 11.44 3 195133 9284 64294312
Cardiomegaly 18.31 11.44 27 195109 23657 64279939
Epilepsy 18.29 11.44 47 195089 33484 64270112
Electrocardiogram QRS complex prolonged 18.27 11.44 3 195133 9241 64294355
Pain of skin 18.26 11.44 67 195069 9480 64294116
Oral disorder 18.25 11.44 64 195072 8857 64294739
Atrial flutter 18.23 11.44 19 195117 19361 64284235
Macule 18.19 11.44 29 195107 2397 64301199
Product administration error 18.15 11.44 35 195101 27608 64275988
Vision blurred 18.13 11.44 180 194956 90136 64213460
Myelodysplastic syndrome 18.04 11.44 35 195101 27544 64276052
Hyperammonaemia 17.91 11.44 4 195132 9900 64293696
Prostatic specific antigen decreased 17.90 11.44 7 195129 61 64303535
Vertebral lesion 17.85 11.44 13 195123 431 64303165
Respiratory acidosis 17.78 11.44 4 195132 9851 64293745
Carcinoembryonic antigen increased 17.78 11.44 25 195111 1848 64301748
Nail disorder 17.76 11.44 62 195074 8562 64295034
Irritable bowel syndrome 17.72 11.44 56 195080 37313 64266283
Blood pressure systolic increased 17.72 11.44 83 195053 49370 64254226
Aspiration 17.71 11.44 15 195121 16870 64286726
Toxic encephalopathy 17.68 11.44 4 195132 9811 64293785
Osteosclerosis 17.53 11.44 35 195101 3451 64300145
Hypotonia 17.53 11.44 6 195130 11206 64292390
Thyroid operation 17.53 11.44 9 195127 156 64303440
Duodenal ulcer 17.51 11.44 11 195125 14424 64289172
Metastases to bladder 17.31 11.44 10 195126 221 64303375
Therapeutic product effect incomplete 17.30 11.44 215 194921 103267 64200329
Blood glucose decreased 17.26 11.44 27 195109 23096 64280500
Cough 17.20 11.44 743 194393 301405 64002191
Chemotherapy 17.19 11.44 22 195114 1485 64302111
Diffuse large B-cell lymphoma 17.17 11.44 5 195131 10356 64293240
Macroenzyme creatine kinase 17.13 11.44 5 195131 15 64303581
Failure to anastomose 17.11 11.44 10 195126 226 64303370
Extraskeletal ossification 17.05 11.44 7 195129 70 64303526
CYP3A4 polymorphism 17.05 11.44 7 195129 70 64303526
Myopathy 17.01 11.44 17 195119 17663 64285933
Troponin increased 17.00 11.44 13 195123 15386 64288210
Breath sounds abnormal 16.98 11.44 7 195129 11662 64291934
Metastases to soft tissue 16.96 11.44 12 195124 380 64303216
Speech disorder 16.95 11.44 82 195054 48359 64255237
Clavicle fracture 16.92 11.44 36 195100 3713 64299883
Oral mucosal erythema 16.92 11.44 23 195113 1646 64301950
Sleep apnoea syndrome 16.91 11.44 41 195095 29791 64273805
Colitis 16.87 11.44 106 195030 58568 64245028
Bone scan abnormal 16.84 11.44 9 195127 170 64303426
Blood creatinine abnormal 16.78 11.44 38 195098 4089 64299507
Erysipelas 16.76 11.44 63 195073 9018 64294578
Fibula fracture 16.74 11.44 32 195104 3056 64300540
Onychalgia 16.69 11.44 16 195120 781 64302815
Dental cyst 16.66 11.44 5 195131 17 64303579
Vertebral wedging 16.66 11.44 5 195131 17 64303579
Body temperature increased 16.66 11.44 56 195080 36610 64266986
Acute generalised exanthematous pustulosis 16.66 11.44 11 195125 14047 64289549
Hyperbilirubinaemia 16.56 11.44 24 195112 21181 64282415
Drug eruption 16.55 11.44 55 195081 36081 64267515
Facial pain 16.47 11.44 57 195079 7838 64295758
Splenomegaly 16.46 11.44 18 195118 17943 64285653
Hypercalcaemic nephropathy 16.45 11.44 4 195132 4 64303592
Diverticulitis 16.41 11.44 184 194952 38434 64265162
Patella fracture 16.39 11.44 22 195114 1556 64302040
Allergy to plants 16.33 11.44 14 195122 590 64303006
Skin haemorrhage 16.21 11.44 60 195076 8525 64295071
Erectile dysfunction 16.19 11.44 9 195127 12618 64290978
Brain injury 16.17 11.44 5 195131 9960 64293636
Lipase increased 16.10 11.44 12 195124 14390 64289206
Ileus 16.04 11.44 28 195108 22938 64280658
Palpitations 16.03 11.44 221 194915 104267 64199329
Parathyroid gland operation 16.03 11.44 5 195131 20 64303576
Epistaxis 15.99 11.44 205 194931 97926 64205670
Metastases to peritoneum 15.94 11.44 34 195102 3513 64300083
Hypercalciuria 15.89 11.44 12 195124 421 64303175
VIth nerve paresis 15.82 11.44 8 195128 134 64303462
Device malfunction 15.79 11.44 18 195118 17615 64285981
Gingival discolouration 15.74 11.44 9 195127 195 64303401
Electrolyte imbalance 15.69 11.44 33 195103 25210 64278386
Spinal disorder 15.68 11.44 60 195076 8662 64294934
Cardiac failure chronic 15.66 11.44 4 195132 9037 64294559
Migraine 15.66 11.44 118 195018 62559 64241037
Wrong technique in product usage process 15.64 11.44 280 194856 64694 64238902
Platelet count decreased 15.61 11.44 387 194749 167324 64136272
Ventricular extrasystoles 15.59 11.44 18 195118 17511 64286085
Chronic leukaemia 15.57 11.44 4 195132 6 64303590
Chromaturia 15.40 11.44 28 195108 22583 64281013
Rotator cuff syndrome 15.38 11.44 75 195061 12032 64291564
Euthanasia 15.37 11.44 6 195130 52 64303544
Blood pressure abnormal 15.28 11.44 85 195051 14350 64289246
Colitis ulcerative 15.26 11.44 29 195107 22999 64280597
Hepatic function abnormal 15.18 11.44 123 195013 64190 64239406
Sputum discoloured 15.17 11.44 19 195117 17837 64285759
Lip exfoliation 15.17 11.44 13 195123 548 64303048
Blood pressure systolic decreased 15.09 11.44 4 195132 8816 64294780
Immune thrombocytopenia 15.06 11.44 14 195122 15052 64288544
Wisdom teeth removal 15.02 11.44 11 195125 368 64303228
Treatment noncompliance 14.99 11.44 74 195062 43408 64260188
Clostridium difficile colitis 14.97 11.44 38 195098 27185 64276411
Generalised oedema 14.95 11.44 25 195111 20828 64282768
Burning sensation 14.93 11.44 222 194914 49442 64254154
Polyneuropathy in malignant disease 14.92 11.44 8 195128 152 64303444
Injection site haemorrhage 14.87 11.44 32 195104 24246 64279350
Blood pressure diastolic decreased 14.85 11.44 28 195108 22273 64281323
Hypocalcaemic seizure 14.82 11.44 5 195131 27 64303569
Skin sensitisation 14.78 11.44 15 195121 785 64302811
Sense of oppression 14.76 11.44 20 195116 1427 64302169
Skin necrosis 14.70 11.44 13 195123 14316 64289280
Skin disorder 14.68 11.44 138 194998 27542 64276054
Encephalitis 14.68 11.44 10 195126 12561 64291035
Pulmonary embolism 14.65 11.44 334 194802 146022 64157574
Fear 14.63 11.44 24 195112 20147 64283449
Blood culture positive 14.59 11.44 3 195133 7865 64295731
Cholecystitis 14.59 11.44 23 195113 19613 64283983
Mental disorder 14.48 11.44 37 195099 26408 64277188
Febrile bone marrow aplasia 14.47 11.44 8 195128 11247 64292349
Electrocardiogram QT prolonged 14.46 11.44 162 194974 79286 64224310
Pleural neoplasm 14.42 11.44 9 195127 230 64303366
Macular degeneration 14.41 11.44 44 195092 5666 64297930
Diabetic endorgan damage 14.41 11.44 3 195133 0 64303596
Injection site movement impairment 14.41 11.44 3 195133 0 64303596
Periodontal operation 14.41 11.44 3 195133 0 64303596
Bone metabolism biochemical marker increased 14.41 11.44 3 195133 0 64303596
Serum procollagen type I N-terminal propeptide decreased 14.41 11.44 3 195133 0 64303596
Tuberculosis 14.40 11.44 11 195125 13027 64290569
Therapy interrupted 14.38 11.44 24 195112 20012 64283584
Intramedullary rod insertion 14.30 11.44 8 195128 166 64303430
Fistula 14.27 11.44 63 195073 9698 64293898
Eosinophil count increased 14.24 11.44 13 195123 14099 64289497
Hepatic necrosis 14.21 11.44 4 195132 8469 64295127
Malocclusion 13.97 11.44 7 195129 115 64303481
Lip and/or oral cavity cancer 13.96 11.44 12 195124 508 64303088
Immobile 13.94 11.44 45 195091 5970 64297626
Catatonia 13.94 11.44 3 195133 7617 64295979
Ear disorder 13.87 11.44 30 195106 3130 64300466
Dermatitis exfoliative 13.83 11.44 7 195129 10345 64293251
Upper respiratory tract infection 13.81 11.44 147 194989 72638 64230958
Bone cancer metastatic 13.80 11.44 8 195128 178 64303418
Platelet count increased 13.79 11.44 22 195114 18674 64284922
Gait inability 13.77 11.44 192 194944 42176 64261420
Neurotoxicity 13.76 11.44 40 195096 27364 64276232
Arteriosclerosis coronary artery 13.75 11.44 16 195120 15513 64288083
Vulvovaginal rash 13.73 11.44 6 195130 71 64303525
Mucosal pain 13.71 11.44 4 195132 12 64303584
Hypovolaemic shock 13.63 11.44 7 195129 10259 64293337
Malpositioned teeth 13.61 11.44 5 195131 36 64303560
Mood altered 13.58 11.44 17 195119 15962 64287634
Gastritis erosive 13.57 11.44 6 195130 9589 64294007
International normalised ratio decreased 13.56 11.44 3 195133 7475 64296121
Vascular fragility 13.55 11.44 7 195129 123 64303473
Polyuria 13.54 11.44 11 195125 12632 64290964
Bacterial sepsis 13.51 11.44 3 195133 7454 64296142
Vipoma 13.47 11.44 4 195132 13 64303583
Ventricular arrhythmia 13.40 11.44 3 195133 7412 64296184
Pruritus 13.36 11.44 1108 194028 311292 63992304
Visual acuity reduced 13.35 11.44 40 195096 27101 64276495
Motor dysfunction 13.34 11.44 9 195127 11364 64292232
Tumour lysis syndrome 13.31 11.44 24 195112 19416 64284180
Urine abnormality 13.26 11.44 3 195133 7359 64296237
Brachiocephalic vein thrombosis 13.25 11.44 7 195129 129 64303467
Hypertension 13.24 11.44 645 194491 258616 64044980
Skin exfoliation 13.24 11.44 200 194936 44685 64258911
Conjunctivitis 13.17 11.44 26 195110 20328 64283268
Fracture pain 13.16 11.44 10 195126 354 64303242
Hip arthroplasty 13.16 11.44 110 195026 21241 64282355
Hypoaesthesia teeth 13.15 11.44 5 195131 40 64303556
Chronic kidney disease 13.11 11.44 112 195024 57807 64245789
Post procedural haemorrhage 13.09 11.44 11 195125 12420 64291176
Spinal fusion surgery 13.09 11.44 32 195104 3619 64299977
Injection site bruising 13.06 11.44 61 195075 36312 64267284
Tenosynovitis 13.05 11.44 10 195126 11823 64291773
Lymphocyte count decreased 13.05 11.44 71 195065 40628 64262968
Injected limb mobility decreased 13.03 11.44 4 195132 15 64303581
Extradural neoplasm 13.03 11.44 4 195132 15 64303581
Electrocardiogram ST segment elevation 12.99 11.44 3 195133 7256 64296340
Blood phosphorus abnormal 12.97 11.44 9 195127 276 64303320
Jaundice cholestatic 12.94 11.44 5 195131 8665 64294931
Electrocardiogram abnormal 12.92 11.44 13 195123 13468 64290128
Tachyphylaxis 12.91 11.44 9 195127 278 64303318
Blister 12.87 11.44 170 194966 80797 64222799
Atrophic vulvovaginitis 12.87 11.44 17 195119 1184 64302412
Pulmonary tumour thrombotic microangiopathy 12.83 11.44 6 195130 84 64303512
Bladder disorder 12.81 11.44 52 195084 7715 64295881
Ocular hyperaemia 12.80 11.44 31 195105 22533 64281063
Cerebral haematoma 12.80 11.44 3 195133 7182 64296414
Injection site swelling 12.79 11.44 73 195063 41280 64262316
Blood lactate dehydrogenase increased 12.77 11.44 54 195082 33024 64270572
Periprosthetic fracture 12.72 11.44 12 195124 574 64303022
Hypoxic-ischaemic encephalopathy 12.71 11.44 3 195133 7149 64296447
Aplastic anaemia 12.70 11.44 14 195122 13906 64289690
Acute pulmonary oedema 12.69 11.44 12 195124 12797 64290799
Pulmonary fibrosis 12.66 11.44 47 195089 29831 64273765
Giant cell arteritis 12.65 11.44 24 195112 2279 64301317
Carbohydrate antigen 27.29 increased 12.64 11.44 5 195131 45 64303551
Metastases to vagina 12.63 11.44 4 195132 17 64303579
Osteoporosis postmenopausal 12.63 11.44 4 195132 17 64303579
Faeces discoloured 12.60 11.44 38 195098 25691 64277905
Urine output decreased 12.55 11.44 19 195117 16473 64287123
Lymphopenia 12.49 11.44 38 195098 25619 64277977
Blood 1,25-dihydroxycholecalciferol increased 12.45 11.44 4 195132 18 64303578
Breast disorder 12.45 11.44 20 195116 1664 64301932
Colonoscopy 12.44 11.44 20 195116 1665 64301931
Gastroenteritis 12.42 11.44 47 195089 29664 64273932
Staphylococcal bacteraemia 12.41 11.44 8 195128 10347 64293249
Peripheral swelling 12.38 11.44 512 194624 208641 64094955
Arteriosclerosis 12.37 11.44 18 195118 15859 64287737
Osteomalacia 12.37 11.44 18 195118 1373 64302223
Eastern Cooperative Oncology Group performance status worsened 12.36 11.44 17 195119 1231 64302365
Dental paraesthesia 12.34 11.44 3 195133 3 64303593
Retinal operation 12.34 11.44 3 195133 3 64303593
Enteritis 12.34 11.44 11 195125 12066 64291530
Oestradiol abnormal 12.28 11.44 4 195132 19 64303577
Ammonia increased 12.26 11.44 3 195133 6974 64296622
Carpal tunnel decompression 12.24 11.44 11 195125 494 64303102
Leukoencephalopathy 12.23 11.44 3 195133 6964 64296632
Atrioventricular block 12.20 11.44 11 195125 12004 64291592
Affect lability 12.13 11.44 6 195130 8984 64294612
Knee arthroplasty 12.10 11.44 130 195006 26869 64276727
Bronchitis 12.09 11.44 244 194892 108499 64195097
Vertigo 12.05 11.44 248 194888 58763 64244833
Oesophagitis 12.05 11.44 30 195106 21600 64281996
Hyperuricaemia 12.04 11.44 8 195128 10183 64293413
Metastatic neoplasm 11.94 11.44 35 195101 4407 64299189
Atrioventricular block first degree 11.93 11.44 9 195127 10725 64292871
Nail avulsion 11.90 11.44 6 195130 100 64303496
Demyelination 11.89 11.44 3 195133 6831 64296765
Cementoplasty 11.88 11.44 3 195133 4 64303592
Gingival cyst 11.88 11.44 3 195133 4 64303592
Bone operation 11.86 11.44 8 195128 234 64303362
Rash erythematous 11.85 11.44 210 194926 48423 64255173
Sternal fracture 11.83 11.44 23 195113 2224 64301372
Ecchymosis 11.83 11.44 15 195121 14007 64289589
Surgery 11.80 11.44 134 195002 28079 64275517
Hypercalcaemia of malignancy 11.79 11.44 9 195127 321 64303275
Pericardial effusion 11.76 11.44 70 195066 39184 64264412
Cholelithiasis 11.69 11.44 85 195051 45421 64258175
Liver function test increased 11.68 11.44 51 195085 30919 64272677
Cataract 11.67 11.44 219 194917 51043 64252553
Spondylolisthesis 11.67 11.44 26 195110 2768 64300828
Breast cancer female 11.67 11.44 38 195098 5065 64298531
Bone density increased 11.66 11.44 11 195125 526 64303070
Granuloma annulare 11.65 11.44 11 195125 527 64303069
Clostridium difficile infection 11.64 11.44 63 195073 36100 64267496
Hepatotoxicity 11.59 11.44 72 195064 39890 64263706
Blood potassium increased 11.58 11.44 40 195096 25940 64277656
Coronary artery occlusion 11.57 11.44 15 195121 13876 64289720
Abdominal pain upper 11.55 11.44 423 194713 174607 64128989
Neoplasm 11.53 11.44 47 195089 6984 64296612
Enterococcal infection 11.53 11.44 15 195121 13851 64289745
Invasive lobular breast carcinoma 11.53 11.44 11 195125 534 64303062
Urethritis noninfective 11.50 11.44 4 195132 24 64303572

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M05BX04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Other drugs affecting bone structure and mineralization
MeSH PA D050071 Bone Density Conservation Agents
FDA MoA N0000187054 RANK Ligand Blocking Activity
FDA EPC N0000187055 RANK Ligand Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Drug-induced osteoporosis indication 14651005
Osteoporosis indication 64859006 DOID:11476
Postmenopausal osteoporosis indication 102447009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tumor necrosis factor ligand superfamily member 11 Cytokine ANTIBODY BINDING DRUG LABEL DRUG LABEL

External reference:

IDSource
D03684 KEGG_DRUG
4030131 VUID
N0000181718 NUI
4030131 VANDF
CHEMBL1237023 ChEMBL_ID
6886 IUPHAR_LIGAND_ID
8653 INN_ID
DB06643 DRUGBANK_ID
4EQZ6YO2HI UNII
993449 RXNORM
173191 MMSL
27218 MMSL
d07640 MMSL
446321003 SNOMEDCT_US
446457007 SNOMEDCT_US
D000069448 MESH_DESCRIPTOR_UI
C1690432 UMLSCUI
013441 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Prolia HUMAN PRESCRIPTION DRUG LABEL 1 55513-710 INJECTION 60 mg SUBCUTANEOUS BLA 34 sections
Prolia HUMAN PRESCRIPTION DRUG LABEL 1 55513-710 INJECTION 60 mg SUBCUTANEOUS BLA 34 sections
XGEVA HUMAN PRESCRIPTION DRUG LABEL 1 55513-730 INJECTION 120 mg SUBCUTANEOUS BLA 29 sections