ergocalciferol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 2838 50-14-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ergocalciferol
  • vitamin D2
  • calciferol
  • ercalciol
  • ergorone
  • Molecular weight: 396.66
  • Formula: C28H44O
  • CLOGP: 9.39
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -5.96
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.86 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Jan. 11, 1941 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 847.77 10.27 277 383120 212222 50009505
Completed suicide 651.98 10.27 108 383289 131781 50089946
Pemphigus 415.60 10.27 195 383202 119971 50101756
Drug interaction 395.22 10.27 562 382835 199059 50022668
Multiple sclerosis relapse 368.10 10.27 926 382471 42038 50179689
Drug abuse 362.08 10.27 23 383374 59823 50161904
Drug ineffective 338.82 10.27 4286 379111 815047 49406680
Intentional overdose 330.04 10.27 42 383355 62462 50159265
Systemic lupus erythematosus 315.44 10.27 360 383037 140262 50081465
Contraindicated product administered 310.21 10.27 404 382993 148554 50073173
Product dose omission issue 282.28 10.27 2367 381030 181471 50040256
Muscle spasms 276.28 10.27 1762 381635 123791 50097936
Glossodynia 273.41 10.27 283 383114 115286 50106441
Hand deformity 269.52 10.27 218 383179 99981 50121746
Exposure during pregnancy 263.65 10.27 317 383080 120698 50101029
Overdose 263.26 10.27 221 383176 99506 50122221
Back pain 250.84 10.27 2659 380738 217371 50004356
Fatigue 231.89 10.27 7000 376397 700601 49521126
Acute kidney injury 230.12 10.27 918 382479 227140 49994587
Maternal exposure during pregnancy 224.84 10.27 553 382844 159225 50062502
Infusion related reaction 199.24 10.27 640 382757 168917 50052810
Headache 196.47 10.27 5122 378275 501413 49720314
Synovitis 194.32 10.27 404 382993 123461 50098266
Pain in extremity 178.49 10.27 2981 380416 269884 49951843
Hypoaesthesia 176.64 10.27 1603 381794 125654 50096073
Cardio-respiratory arrest 166.34 10.27 101 383296 53791 50167936
Pericarditis 163.11 10.27 214 383183 78475 50143252
Feeling abnormal 162.73 10.27 1558 381839 123934 50097793
Infective pulmonary exacerbation of cystic fibrosis 159.98 10.27 245 383152 7664 50214063
Multiple organ dysfunction syndrome 155.83 10.27 94 383303 50243 50171484
Diarrhoea 155.59 10.27 5679 377718 582797 49638930
Wound 153.63 10.27 360 383037 105434 50116293
Depressed level of consciousness 152.63 10.27 103 383294 51850 50169877
White blood cell count decreased 151.27 10.27 1449 381948 115273 50106454
Febrile neutropenia 150.26 10.27 322 383075 97345 50124382
Multiple sclerosis 149.35 10.27 416 382981 20077 50201650
Drug intolerance 149.21 10.27 1009 382388 218095 50003632
Thrombocytopenia 148.46 10.27 484 382913 127189 50094538
Fall 147.17 10.27 3446 379951 331486 49890241
Cardiac arrest 146.79 10.27 255 383142 83396 50138331
Hepatic function abnormal 144.18 10.27 35 383362 32646 50189081
Suicide attempt 143.55 10.27 109 383288 51623 50170104
Influenza like illness 141.80 10.27 831 382566 56628 50165099
Memory impairment 141.42 10.27 1058 382339 78302 50143425
Bone pain 137.95 10.27 715 382682 46514 50175213
Hypotension 137.63 10.27 1132 382265 234337 49987390
General physical health deterioration 137.48 10.27 583 382814 141851 50079876
Insomnia 135.78 10.27 1967 381430 172898 50048829
Hyponatraemia 129.54 10.27 340 383057 95799 50125928
Anti-cyclic citrullinated peptide antibody positive 126.76 10.27 212 383185 70375 50151352
Treatment failure 125.78 10.27 575 382822 137062 50084665
Asthenia 124.38 10.27 3230 380167 315812 49905915
Gait disturbance 124.32 10.27 1707 381690 148298 50073429
Paraesthesia 121.64 10.27 1420 381977 118823 50102904
Drug reaction with eosinophilia and systemic symptoms 115.00 10.27 36 383361 28388 50193339
Drug hypersensitivity 111.93 10.27 1289 382108 249721 49972006
Electrocardiogram QT prolonged 110.73 10.27 138 383259 51748 50169979
Full blood count decreased 110.72 10.27 397 383000 21949 50199778
Off label use 110.07 10.27 4515 378882 469911 49751816
Muscle spasticity 109.04 10.27 332 383065 16852 50204875
Hyperkalaemia 107.85 10.27 123 383274 47966 50173761
Discomfort 106.79 10.27 440 382957 107940 50113787
Hepatocellular injury 106.53 10.27 32 383365 25915 50195812
Cardiac failure 106.22 10.27 264 383133 75776 50145951
Neutropenia 105.91 10.27 671 382726 147294 50074433
Night sweats 105.57 10.27 519 382878 33055 50188672
Metabolic acidosis 104.93 10.27 84 383313 38741 50182986
Pancytopenia 104.41 10.27 309 383088 83721 50138006
Body height decreased 103.96 10.27 217 383180 8691 50213036
Lactic acidosis 103.64 10.27 62 383335 33293 50188434
Arthropathy 102.10 10.27 738 382659 157168 50064559
Ear pain 101.98 10.27 455 382942 27828 50193899
Constipation 99.13 10.27 1966 381431 183742 50037985
Intentional self-injury 97.65 10.27 27 383370 23085 50198642
Septic shock 96.07 10.27 179 383218 56996 50164731
Rhabdomyolysis 94.01 10.27 94 383303 38933 50182794
Bradycardia 92.88 10.27 220 383177 64206 50157521
Psoriasis 92.53 10.27 863 382534 68137 50153590
Burning sensation 91.45 10.27 624 382773 44822 50176905
Muscular weakness 89.90 10.27 1108 382289 93905 50127822
Swelling 89.31 10.27 1032 382365 199840 50021887
Death 88.08 10.27 1838 381559 323541 49898186
Vitamin D deficiency 87.60 10.27 236 383161 11166 50210561
Gastrooesophageal reflux disease 87.49 10.27 925 382472 75503 50146224
Vitamin D decreased 86.92 10.27 195 383202 8211 50213516
Mucosal inflammation 86.45 10.27 106 383291 40036 50181691
Urinary tract infection 83.12 10.27 2254 381143 221766 49999961
Blood calcium increased 81.99 10.27 181 383216 7538 50214189
Folliculitis 80.93 10.27 107 383290 39118 50182609
Hepatotoxicity 79.93 10.27 54 383343 27172 50194555
Confusional state 79.26 10.27 964 382433 184964 50036763
Influenza 77.85 10.27 1028 382369 88510 50133217
Muscle injury 77.83 10.27 100 383297 37011 50184716
Cytomegalovirus infection 77.75 10.27 20 383377 17942 50203785
Respiratory failure 77.39 10.27 391 383006 90790 50130937
Limb discomfort 76.92 10.27 377 383020 23980 50197747
Cholestasis 75.08 10.27 50 383347 25351 50196376
Hip fracture 74.62 10.27 391 383006 25540 50196187
Weight decreased 73.98 10.27 2197 381200 219048 50002679
Spinal fracture 73.20 10.27 272 383125 15301 50206426
Respiratory arrest 72.60 10.27 72 383325 29937 50191790
Agranulocytosis 72.10 10.27 36 383361 21385 50200342
Dry skin 71.99 10.27 567 382830 42624 50179103
Neuroleptic malignant syndrome 71.32 10.27 3 383394 11127 50210600
Therapeutic product effect decreased 71.02 10.27 673 382724 135377 50086350
Hypokalaemia 70.93 10.27 384 383013 87608 50134119
Myalgia 70.32 10.27 1328 382069 122991 50098736
Foetal exposure during pregnancy 69.28 10.27 63 383334 27296 50194431
Carpal tunnel syndrome 68.79 10.27 282 383115 16611 50205116
Helicobacter infection 67.51 10.27 175 383222 49527 50172200
Duodenal ulcer perforation 67.14 10.27 154 383243 45457 50176270
Malignant neoplasm progression 66.19 10.27 278 383119 67846 50153881
Bone marrow failure 66.00 10.27 67 383330 27557 50194170
Dizziness 66.00 10.27 3232 380165 343137 49878590
Hepatic failure 65.64 10.27 89 383308 32194 50189533
Drug resistance 65.30 10.27 31 383366 18958 50202769
Coma 65.12 10.27 217 383180 56662 50165065
Chills 65.11 10.27 1062 382335 95625 50126102
Neutropenic sepsis 64.70 10.27 14 383383 14133 50207594
Shock 64.69 10.27 38 383359 20612 50201115
Plasma cell myeloma 64.16 10.27 432 382965 30890 50190837
Balance disorder 64.10 10.27 817 382580 69773 50151954
Depression 62.61 10.27 1669 381728 163754 50057973
Agitation 62.26 10.27 202 383195 53182 50168545
Rash maculo-papular 62.09 10.27 66 383331 26575 50195152
Cerebral infarction 61.89 10.27 44 383353 21560 50200167
Poisoning 61.75 10.27 10 383387 12419 50209308
Sedation 61.62 10.27 85 383312 30525 50191202
Inappropriate schedule of product administration 61.31 10.27 822 382575 71009 50150718
Toxic epidermal necrolysis 61.14 10.27 42 383355 20950 50200777
Leukopenia 60.52 10.27 284 383113 67244 50154483
Hepatic enzyme increased 60.16 10.27 708 382689 136672 50085055
Pyrexia 59.97 10.27 2315 381082 377888 49843839
Sinusitis 59.81 10.27 1704 381693 168854 50052873
Atypical femur fracture 58.83 10.27 121 383276 4795 50216932
Sinus disorder 57.78 10.27 285 383112 18173 50203554
Neurotoxicity 57.29 10.27 20 383377 14720 50207007
Osteoarthritis 56.87 10.27 781 382616 67825 50153902
Full blood count abnormal 56.86 10.27 337 383060 23051 50198676
Respiratory depression 56.76 10.27 11 383386 11999 50209728
Myelosuppression 56.72 10.27 16 383381 13501 50208226
Tachycardia 56.64 10.27 483 382914 99280 50122447
Osteopenia 56.32 10.27 267 383130 16751 50204976
Altered state of consciousness 56.02 10.27 50 383347 21860 50199867
Toxic skin eruption 56.01 10.27 9 383388 11242 50210485
Serotonin syndrome 55.63 10.27 63 383334 24650 50197077
Rhinorrhoea 55.63 10.27 617 382780 50966 50170761
Bronchitis 55.61 10.27 1103 382294 103056 50118671
Neck pain 55.04 10.27 668 382729 56399 50165328
Injection site reaction 54.67 10.27 600 382797 49432 50172295
Jaundice 54.61 10.27 72 383325 26357 50195370
Abdominal pain upper 54.03 10.27 1585 381812 157724 50064003
Anaphylactic reaction 53.50 10.27 219 383178 53836 50167891
Arthralgia 53.20 10.27 3933 379464 434769 49786958
Sepsis 52.96 10.27 699 382698 132226 50089501
Anaphylactic shock 52.73 10.27 45 383352 20110 50201617
Ejection fraction decreased 52.69 10.27 38 383359 18482 50203245
Drug-induced liver injury 52.66 10.27 82 383315 28013 50193714
Hot flush 52.62 10.27 539 382858 43630 50178097
Pollakiuria 51.91 10.27 334 383063 23517 50198210
Dry mouth 51.76 10.27 652 382745 55526 50166201
Stevens-Johnson syndrome 51.69 10.27 53 383344 21699 50200028
Premature baby 51.68 10.27 38 383359 18299 50203428
Renal failure 51.25 10.27 538 382859 106095 50115632
Neuropathy peripheral 50.77 10.27 1022 382375 95735 50125992
Hypoglycaemia 50.61 10.27 221 383176 53360 50168367
Recalled product 49.96 10.27 56 383341 1279 50220448
Flatulence 49.79 10.27 388 383009 29070 50192657
Torsade de pointes 49.67 10.27 14 383383 11821 50209906
Blood test abnormal 49.33 10.27 193 383204 11126 50210601
Taste disorder 49.27 10.27 157 383240 8167 50213560
Tooth disorder 48.93 10.27 333 383064 23895 50197832
Acute hepatic failure 48.90 10.27 29 383368 15648 50206079
Dysgeusia 48.82 10.27 480 382917 38436 50183291
Wrist fracture 48.56 10.27 194 383203 11293 50210434
Anaemia 48.10 10.27 1501 381896 250955 49970772
Mydriasis 47.62 10.27 11 383386 10616 50211111
Interstitial lung disease 47.43 10.27 224 383173 52952 50168775
Peripheral swelling 47.31 10.27 1959 381438 203977 50017750
Pruritus 47.25 10.27 2613 380784 280955 49940772
Ventricular fibrillation 47.18 10.27 11 383386 10548 50211179
Ill-defined disorder 47.14 10.27 233 383164 54421 50167306
Hepatic cytolysis 46.47 10.27 4 383393 8099 50213628
Myoclonus 46.22 10.27 26 383371 14444 50207283
Circulatory collapse 46.10 10.27 50 383347 19950 50201777
Femur fracture 45.50 10.27 459 382938 37005 50184722
Red blood cell count decreased 45.24 10.27 423 382974 33412 50188315
Sleep apnoea syndrome 45.23 10.27 323 383074 23545 50198182
Encephalopathy 44.79 10.27 120 383277 33591 50188136
Medication error 44.66 10.27 133 383264 35971 50185756
Nephrolithiasis 44.54 10.27 430 382967 34263 50187464
Vision blurred 43.71 10.27 838 382559 77809 50143918
Rib fracture 43.58 10.27 272 383125 18949 50202778
Blister 43.51 10.27 425 382972 84993 50136734
Abdominal distension 43.36 10.27 785 382612 72118 50149609
Mycotic allergy 42.62 10.27 41 383356 778 50220949
Alanine aminotransferase increased 42.37 10.27 446 382951 87913 50133814
Ascites 42.30 10.27 135 383262 35726 50186001
Micturition urgency 41.94 10.27 148 383249 8116 50213611
Melaena 41.76 10.27 88 383309 26776 50194951
Sleep disorder due to general medical condition, insomnia type 41.73 10.27 112 383285 31335 50190392
Pre-existing condition improved 41.23 10.27 133 383264 6964 50214763
Acute respiratory distress syndrome 41.07 10.27 60 383337 21039 50200688
Cataract 41.06 10.27 543 382854 46757 50174970
Extrapyramidal disorder 40.80 10.27 19 383378 11751 50209976
Sensitisation 40.79 10.27 55 383342 1527 50220200
Blood pressure abnormal 40.74 10.27 198 383199 12549 50209178
Posterior reversible encephalopathy syndrome 40.71 10.27 32 383365 14896 50206831
Cardiogenic shock 40.60 10.27 35 383362 15564 50206163
Pneumocystis jirovecii pneumonia 40.53 10.27 31 383366 14632 50207095
Lymphocyte count decreased 40.39 10.27 339 383058 25968 50195759
Angioedema 40.26 10.27 148 383249 37528 50184199
Seasonal allergy 39.98 10.27 218 383179 14458 50207269
Foot fracture 39.89 10.27 275 383122 19816 50201911
Product use in unapproved indication 39.82 10.27 627 382770 115192 50106535
Drug eruption 39.56 10.27 74 383323 23532 50198195
Thoracic vertebral fracture 39.36 10.27 92 383305 3981 50217746
Dry eye 39.35 10.27 394 383003 31701 50190026
Nasal congestion 39.18 10.27 574 382823 50546 50171181
Gamma-glutamyltransferase increased 38.94 10.27 106 383291 29517 50192210
Premature delivery 38.93 10.27 75 383322 23588 50198139
Hypoacusis 38.88 10.27 279 383118 20368 50201359
Bone density abnormal 38.88 10.27 77 383320 2968 50218759
Hypertensive crisis 38.73 10.27 26 383371 13128 50208599
Blood lactate dehydrogenase increased 38.70 10.27 55 383342 19507 50202220
Gastrointestinal haemorrhage 38.53 10.27 362 383035 72959 50148768
Transaminases increased 38.53 10.27 97 383300 27727 50194000
Cystic fibrosis 38.49 10.27 74 383323 2790 50218937
Injection site erythema 38.47 10.27 789 382608 74147 50147580
Central nervous system lesion 38.32 10.27 158 383239 9331 50212396
Disseminated intravascular coagulation 38.22 10.27 44 383353 17091 50204636
Lumbar vertebral fracture 38.22 10.27 98 383299 4499 50217228
Blood pressure diastolic abnormal 37.61 10.27 12 383385 9349 50212378
Abortion induced 37.50 10.27 12 383385 9332 50212395
Sedation complication 37.48 10.27 10 383387 8756 50212971
Injection site pain 37.45 10.27 1104 382293 109920 50111807
Stress fracture 37.40 10.27 126 383271 6749 50214978
Irritable bowel syndrome 36.90 10.27 233 383164 51208 50170519
Cough 36.85 10.27 2206 381191 239058 49982669
Bone density decreased 36.82 10.27 174 383223 10901 50210826
Migraine 36.81 10.27 787 382610 74493 50147234
Haematemesis 36.60 10.27 99 383298 27626 50194101
Bowel movement irregularity 36.58 10.27 88 383309 3880 50217847
Musculoskeletal discomfort 36.43 10.27 215 383182 14683 50207044
Therapy cessation 36.20 10.27 328 383069 25683 50196044
Premature labour 36.12 10.27 21 383376 11455 50210272
Liver function test abnormal 35.99 10.27 193 383204 44146 50177581
Hypervitaminosis D 35.87 10.27 16 383381 70 50221657
Neuralgia 35.87 10.27 286 383111 21577 50200150
Aspartate aminotransferase increased 35.67 10.27 398 382999 77600 50144127
Glaucoma 35.58 10.27 222 383175 15464 50206263
Aggression 35.56 10.27 66 383331 21050 50200677
International normalised ratio increased 35.49 10.27 187 383210 42965 50178762
Face oedema 35.44 10.27 50 383347 17789 50203938
Acute generalised exanthematous pustulosis 34.96 10.27 12 383385 8926 50212801
Injection site bruising 34.84 10.27 429 382968 36339 50185388
Accidental overdose 34.74 10.27 59 383338 19474 50202253
Urine leukocyte esterase positive 34.54 10.27 71 383326 2812 50218915
Body temperature increased 34.30 10.27 376 383021 30965 50190762
Coronary artery disease 34.30 10.27 113 383284 29613 50192114
Product use issue 34.24 10.27 866 382531 148609 50073118
Thrombosis 34.19 10.27 604 382793 55229 50166498
Oropharyngeal pain 34.16 10.27 801 382596 77000 50144727
Respiratory disorder 34.06 10.27 374 383023 30813 50190914
Ventricular tachycardia 33.83 10.27 42 383355 15779 50205948
Haematotoxicity 33.77 10.27 9 383388 7886 50213841
Upper limb fracture 33.76 10.27 221 383176 15652 50206075
Diverticulitis 33.56 10.27 392 383005 32790 50188937
Pathological fracture 33.49 10.27 131 383266 7551 50214176
Delirium 33.41 10.27 162 383235 38030 50183697
Pleural effusion 32.91 10.27 427 382970 81027 50140700
Tooth extraction 32.71 10.27 146 383251 8929 50212798
Blood creatine phosphokinase increased 32.70 10.27 97 383300 26270 50195457
Blood parathyroid hormone increased 32.69 10.27 69 383328 2785 50218942
Psychotic disorder 32.62 10.27 73 383324 21739 50199988
Gastrointestinal pain 32.42 10.27 134 383263 7922 50213805
Vitamin D increased 32.02 10.27 30 383367 550 50221177
Stress 31.90 10.27 579 382818 53214 50168513
Drug level increased 31.76 10.27 61 383336 19207 50202520
Dyspepsia 31.65 10.27 760 382637 73337 50148390
Febrile bone marrow aplasia 31.53 10.27 5 383392 6306 50215421
Cytokine release syndrome 31.41 10.27 13 383384 8621 50213106
Haemodialysis 31.39 10.27 12 383385 8350 50213377
Ischaemic stroke 31.39 10.27 45 383352 15903 50205824
Injection site mass 31.35 10.27 215 383182 15465 50206262
Peroneal nerve palsy 31.26 10.27 87 383310 4196 50217531
Blood 25-hydroxycholecalciferol increased 31.12 10.27 8 383389 0 50221727
Ankle fracture 31.10 10.27 215 383182 15507 50206220
Bone loss 31.07 10.27 65 383332 2607 50219120
Intramedullary rod insertion 31.06 10.27 55 383342 1945 50219782
Skin discolouration 30.95 10.27 382 383015 32375 50189352
Anuria 30.79 10.27 24 383373 11220 50210507
Erythema multiforme 30.77 10.27 15 383382 9035 50212692
Loss of consciousness 30.69 10.27 581 382816 103772 50117955
Polyneuropathy 30.63 10.27 28 383369 12103 50209624
Myocardial infarction 30.25 10.27 483 382914 88544 50133183
Hypervitaminosis 30.24 10.27 11 383386 24 50221703
Bronchopulmonary aspergillosis 30.03 10.27 10 383387 7582 50214145
Contusion 29.94 10.27 1085 382312 111098 50110629
Caesarean section 29.93 10.27 45 383352 15594 50206133
Ejection fraction 29.85 10.27 41 383356 1159 50220568
Pulmonary mass 29.77 10.27 243 383154 18462 50203265
Immune system disorder 29.47 10.27 132 383265 8085 50213642
Nausea 29.47 10.27 5911 377486 699487 49522240
Hyperbilirubinaemia 29.43 10.27 18 383379 9552 50212175
Urine abnormality 29.35 10.27 109 383288 6129 50215598
Thrombotic microangiopathy 29.25 10.27 15 383382 8776 50212951
Psoriatic arthropathy 29.23 10.27 510 382887 46522 50175205
Labelled drug-drug interaction medication error 29.15 10.27 22 383375 10455 50211272
Blood bilirubin increased 29.13 10.27 134 383263 31904 50189823
Asthma 28.94 10.27 884 382513 88453 50133274
Blepharospasm 28.94 10.27 67 383330 2881 50218846
Cyanosis 28.76 10.27 44 383353 15140 50206587
Hypersensitivity 28.60 10.27 1335 382062 213826 50007901
Macular degeneration 28.60 10.27 197 383200 14191 50207536
Tonsillar ulcer 28.54 10.27 21 383376 270 50221457
Laboratory test abnormal 28.49 10.27 285 383112 22923 50198804
Accidental exposure to product 28.47 10.27 85 383312 22972 50198755
Hair texture abnormal 28.41 10.27 76 383321 3580 50218147
Polycystic ovaries 28.39 10.27 60 383337 2424 50219303
Cardiotoxicity 28.24 10.27 9 383388 7018 50214709
Hypocalcaemia 28.11 10.27 319 383078 26497 50195230
Anxiety 27.86 10.27 1628 381769 175978 50045749
Rheumatoid factor positive 27.57 10.27 243 383154 49616 50172111
Palpitations 27.45 10.27 923 382474 93583 50128144
Dystonia 27.28 10.27 30 383367 11896 50209831
Thyroid disorder 27.26 10.27 177 383220 12500 50209227
Status epilepticus 27.21 10.27 37 383360 13369 50208358
Bronchial neoplasm 27.04 10.27 24 383373 409 50221318
Generalised tonic-clonic seizure 27.04 10.27 105 383292 26205 50195522
Pregnancy 26.72 10.27 124 383273 29453 50192274
Parkinsonism 26.71 10.27 17 383380 8830 50212897
Seizure 26.69 10.27 684 382713 117190 50104537
Bone lesion 26.59 10.27 93 383304 5077 50216650
Lower limb fracture 26.53 10.27 192 383205 14054 50207673
Injection site pruritus 26.49 10.27 442 382955 39969 50181758
C-reactive protein increased 26.29 10.27 350 383047 66124 50155603
Brain oedema 26.28 10.27 33 383364 12337 50209390
JC polyomavirus test positive 26.25 10.27 37 383360 1072 50220655
C-reactive protein abnormal 26.07 10.27 115 383282 27694 50194033
Gait spastic 25.97 10.27 19 383378 242 50221485
Nasopharyngitis 25.95 10.27 1745 381652 191182 50030545
Cerebral haemorrhage 25.89 10.27 111 383286 26941 50194786
Syncope 25.71 10.27 589 382808 102413 50119314
Nervousness 25.50 10.27 321 383076 27330 50194397
Nicotine dependence 25.41 10.27 28 383369 627 50221100
Maternal drugs affecting foetus 25.41 10.27 4 383393 5073 50216654
Hospitalisation 25.25 10.27 684 382713 67253 50154474
COVID-19 25.17 10.27 495 382902 46167 50175560
Respiratory tract congestion 25.10 10.27 189 383208 14010 50207717
Restless legs syndrome 25.02 10.27 206 383191 15691 50206036
Drug dependence 25.01 10.27 72 383325 19687 50202040
Productive cough 24.83 10.27 548 382849 52146 50169581
Orthostatic hypotension 24.67 10.27 127 383270 29354 50192373
Sleep disorder due to a general medical condition 24.65 10.27 116 383281 7255 50214472
Akathisia 24.59 10.27 16 383381 8213 50213514
Foreign body in reproductive tract 24.55 10.27 24 383373 465 50221262
Hallucination, auditory 24.53 10.27 27 383370 10701 50211026
Vitamin B12 decreased 24.43 10.27 61 383336 2754 50218973
Bone giant cell tumour 24.34 10.27 9 383388 21 50221706
Muscle tightness 24.27 10.27 147 383250 10133 50211594
Hernia 24.16 10.27 139 383258 9404 50212323
Breast cancer 24.16 10.27 458 382939 42432 50179295
Inappropriate antidiuretic hormone secretion 24.02 10.27 39 383358 13104 50208623
Therapeutic response unexpected 23.86 10.27 204 383193 15711 50206016
Head discomfort 23.79 10.27 154 383243 10865 50210862
Cyst 23.71 10.27 166 383231 12021 50209706
No adverse event 23.62 10.27 153 383244 33425 50188302
Feeling hot 23.61 10.27 423 382974 38779 50182948
Sinus congestion 23.60 10.27 184 383213 13787 50207940
Flushing 23.58 10.27 670 382727 66345 50155382
Gait inability 23.54 10.27 403 382994 36624 50185103
Jaundice cholestatic 23.49 10.27 5 383392 5106 50216621
Abortion spontaneous 23.35 10.27 203 383194 41569 50180158
Coma scale abnormal 23.34 10.27 4 383393 4767 50216960
Bronchial haemorrhage 23.31 10.27 24 383373 496 50221231
Transplant rejection 23.30 10.27 23 383374 9586 50212141
Intentional underdose 23.15 10.27 43 383354 1579 50220148
Hepatic enzyme abnormal 23.04 10.27 85 383312 4764 50216963
Electrocardiogram QRS complex prolonged 23.03 10.27 6 383391 5338 50216389
Injection site urticaria 22.95 10.27 165 383232 12052 50209675
Hyperthermia 22.94 10.27 15 383382 7681 50214046
Creatinine renal clearance decreased 22.92 10.27 34 383363 11847 50209880
Essential hypertension 22.91 10.27 80 383317 4364 50217363
Clostridium difficile infection 22.90 10.27 294 383103 25145 50196582
Cystitis 22.79 10.27 469 382928 44095 50177632
Tooth fracture 22.78 10.27 138 383259 9513 50212214
Gastrointestinal toxicity 22.71 10.27 4 383393 4673 50217054
Shock haemorrhagic 22.61 10.27 18 383379 8326 50213401
Hyperglycaemia 22.60 10.27 172 383225 36233 50185494
Bronchial disorder 22.57 10.27 35 383362 1107 50220620
Pain in jaw 22.56 10.27 413 382984 38015 50183712
Device use error 22.53 10.27 6 383391 5260 50216467
Blood iron decreased 22.48 10.27 158 383239 11457 50210270
Respiratory distress 22.44 10.27 137 383260 30352 50191375
Hepatic necrosis 22.42 10.27 6 383391 5242 50216485
Unevaluable event 22.32 10.27 481 382916 45585 50176142
Hepatitis 22.28 10.27 143 383254 31310 50190417
Coagulopathy 22.26 10.27 66 383331 17878 50203849
Mean cell haemoglobin concentration abnormal 22.16 10.27 11 383386 64 50221663
Venoocclusive liver disease 22.16 10.27 3 383394 4258 50217469
Spinal compression fracture 22.11 10.27 168 383229 12488 50209239
Metastases to central nervous system 22.04 10.27 32 383365 11250 50210477
Abnormal faeces 22.03 10.27 76 383321 4120 50217607
Back disorder 21.93 10.27 133 383264 9172 50212555
Eye swelling 21.73 10.27 241 383156 19903 50201824
Lower respiratory tract infection viral 21.64 10.27 26 383371 641 50221086
Sneezing 21.57 10.27 181 383216 13863 50207864
Nasal turbinate hypertrophy 21.55 10.27 26 383371 644 50221083
Surgery 21.53 10.27 335 383062 29870 50191857
Hypercalcaemia 21.49 10.27 271 383126 23081 50198646
Device expulsion 21.48 10.27 129 383268 28693 50193034
Graft versus host disease 21.30 10.27 10 383387 6156 50215571
Malaise 21.30 10.27 2877 380520 332655 49889072
Spinal operation 21.29 10.27 99 383298 6161 50215566
Fibromyalgia 21.27 10.27 468 382929 44510 50177217
Secondary progressive multiple sclerosis 21.21 10.27 36 383361 1230 50220497
Oral pain 21.15 10.27 286 383111 24747 50196980
Drug tolerance decreased 21.00 10.27 23 383374 9137 50212590
Disorientation 20.94 10.27 170 383227 35314 50186413
Groin pain 20.90 10.27 127 383270 8764 50212963
Miosis 20.65 10.27 11 383386 6299 50215428
Fracture displacement 20.59 10.27 34 383363 1135 50220592
Crying 20.56 10.27 241 383156 20175 50201552
Hepatitis acute 20.55 10.27 18 383379 7943 50213784
Haemophagocytic lymphohistiocytosis 20.55 10.27 21 383376 8612 50213115
Unintended pregnancy 20.48 10.27 6 383391 4940 50216787
Intervertebral disc degeneration 20.42 10.27 173 383224 13288 50208439
Rheumatoid nodule 20.40 10.27 41 383356 12694 50209033
Epstein-Barr virus infection 20.37 10.27 14 383383 6983 50214744
Alopecia 20.37 10.27 1589 381808 243458 49978269
Rhinitis allergic 20.32 10.27 108 383289 7092 50214635
Dry throat 20.25 10.27 90 383307 5494 50216233
Renal impairment 20.21 10.27 428 382969 75233 50146494
Metastases to liver 20.17 10.27 81 383316 20023 50201704
Frequent bowel movements 20.13 10.27 177 383220 13741 50207986
Vitamin D abnormal 20.06 10.27 13 383384 134 50221593
Oxygen saturation decreased 19.96 10.27 413 382984 72835 50148892
Osteomalacia 19.88 10.27 25 383372 647 50221080
Endometriosis 19.84 10.27 72 383325 4003 50217724
Heart rate abnormal 19.84 10.27 71 383326 3921 50217806
Depressed mood 19.74 10.27 365 383032 33658 50188069
Sputum purulent 19.71 10.27 30 383367 933 50220794
Blood calcium abnormal 19.69 10.27 32 383365 1054 50220673
Skin haemorrhage 19.68 10.27 104 383293 6814 50214913
Osteoporosis 19.67 10.27 462 382935 44417 50177310
Bronchospasm 19.63 10.27 53 383344 14801 50206926
Blood potassium decreased 19.62 10.27 391 383006 36554 50185173
Abdominal discomfort 19.58 10.27 1500 381897 230141 49991586
Post transplant lymphoproliferative disorder 19.55 10.27 4 383393 4200 50217527
Concomitant disease progression 19.55 10.27 46 383351 1999 50219728
Oliguria 19.54 10.27 20 383377 8196 50213531
Hypomania 19.53 10.27 5 383392 4500 50217227
Eosinophilia 19.45 10.27 74 383323 18578 50203149
Blood magnesium decreased 19.42 10.27 148 383249 11012 50210715
Foetal death 19.36 10.27 20 383377 8160 50213567
Device difficult to use 19.35 10.27 28 383369 9858 50211869
Decreased interest 19.35 10.27 58 383339 2918 50218809
Endometrial ablation 19.27 10.27 28 383369 835 50220892
Tibia fracture 19.25 10.27 76 383321 4399 50217328
Atrioventricular block complete 19.22 10.27 16 383381 7239 50214488
Dysphonia 19.14 10.27 407 382990 38485 50183242
Paraesthesia oral 19.03 10.27 158 383239 12063 50209664
Onychoclasis 19.03 10.27 84 383313 5112 50216615
Respiratory acidosis 19.01 10.27 11 383386 6017 50215710
Haematoma 19.01 10.27 144 383253 30366 50191361
Sinus tachycardia 19.01 10.27 90 383307 21264 50200463
Gingival pain 18.98 10.27 93 383304 5913 50215814
Cholecystectomy 18.86 10.27 128 383269 9175 50212552
Angina unstable 18.76 10.27 14 383383 6692 50215035
Blood pressure increased 18.75 10.27 1209 382188 131923 50089804
Colitis microscopic 18.54 10.27 98 383299 6422 50215305
Increased tendency to bruise 18.54 10.27 128 383269 9228 50212499
Pelvic fracture 18.51 10.27 150 383247 11370 50210357
Blood cholesterol abnormal 18.49 10.27 48 383349 2220 50219507
Pathogen resistance 18.49 10.27 10 383387 5679 50216048
Malabsorption 18.49 10.27 66 383331 3640 50218087
Left ventricular dysfunction 18.44 10.27 32 383365 10474 50211253
SARS-CoV-2 test positive 18.36 10.27 77 383320 4582 50217145
Palmar-plantar erythrodysaesthesia syndrome 18.31 10.27 84 383313 20014 50201713
Urine odour abnormal 18.29 10.27 85 383312 5288 50216439
Therapeutic response decreased 18.20 10.27 250 383147 46981 50174746
Toothache 18.17 10.27 202 383195 16692 50205035
Lymphocyte percentage decreased 18.14 10.27 54 383343 2706 50219021
Dyspnoea 18.13 10.27 3769 379628 543839 49677888
Mean cell haemoglobin increased 18.12 10.27 47 383350 2173 50219554
Gallbladder operation 18.10 10.27 44 383353 1953 50219774
Acute coronary syndrome 17.91 10.27 27 383370 9347 50212380
Colitis ulcerative 17.89 10.27 201 383196 16653 50205074
Intraductal proliferative breast lesion 17.83 10.27 51 383346 2499 50219228
Hypoxia 17.81 10.27 276 383121 50847 50170880
Open reduction of fracture 17.75 10.27 31 383366 1084 50220643
Panniculitis 17.73 10.27 23 383374 8480 50213247
Injection site swelling 17.69 10.27 428 382969 41345 50180382
Ageusia 17.64 10.27 149 383248 11434 50210293
Dermatitis bullous 17.59 10.27 17 383380 7156 50214571
Angina pectoris 17.58 10.27 121 383276 26067 50195660
Invasive ductal breast carcinoma 17.53 10.27 90 383307 5831 50215896
Bladder hypertrophy 17.52 10.27 14 383383 205 50221522
Haemodynamic instability 17.47 10.27 21 383376 8003 50213724
Urticaria 17.43 10.27 1172 382225 128389 50093338
Illness 17.42 10.27 272 383125 24268 50197459
Weight fluctuation 17.38 10.27 103 383294 7045 50214682
Enterococcal infection 17.32 10.27 16 383381 6882 50214845
Muscle rigidity 17.20 10.27 30 383367 9799 50211928
Bladder operation 17.17 10.27 26 383371 805 50220922
Hallucination, visual 17.15 10.27 66 383331 16516 50205211
Peritonitis 17.09 10.27 60 383337 15426 50206301
Foetal growth restriction 17.09 10.27 15 383382 6612 50215115
Unintentional medical device removal 17.03 10.27 10 383387 5425 50216302
Adverse drug reaction 16.97 10.27 543 382854 54679 50167048
Acute myeloid leukaemia 16.91 10.27 58 383339 15016 50206711
Dental implantation 16.89 10.27 22 383375 590 50221137
Lacrimation increased 16.85 10.27 200 383197 16792 50204935
Low birth weight baby 16.82 10.27 12 383385 5869 50215858
Stomatitis 16.81 10.27 613 382784 100731 50120996
Appetite disorder 16.77 10.27 91 383306 6023 50215704
Type IIa hyperlipidaemia 16.76 10.27 11 383386 116 50221611
Visual impairment 16.69 10.27 654 382743 67621 50154106
Tuberculosis 16.55 10.27 32 383365 10051 50211676
Blood creatinine abnormal 16.53 10.27 51 383346 2607 50219120
Low turnover osteopathy 16.52 10.27 67 383330 3927 50217800
Myocardial ischaemia 16.46 10.27 40 383357 11573 50210154
Urine analysis abnormal 16.45 10.27 71 383326 4279 50217448
Multiple allergies 16.31 10.27 115 383282 8348 50213379
Therapy non-responder 16.27 10.27 280 383117 50742 50170985
Pulmonary tuberculosis 16.26 10.27 6 383391 4267 50217460
Ileus 16.17 10.27 49 383348 13180 50208547
Dysstasia 16.06 10.27 206 383191 17613 50204114
Acute myocardial infarction 16.03 10.27 143 383254 29130 50192597
Pulmonary embolism 16.02 10.27 619 382778 101085 50120642
Temperature regulation disorder 15.98 10.27 6 383391 4221 50217506
Prescribed underdose 15.94 10.27 188 383209 15761 50205966
Stillbirth 15.93 10.27 13 383384 5939 50215788
Dysarthria 15.88 10.27 194 383203 37209 50184518
Blood magnesium increased 15.86 10.27 53 383344 2827 50218900
Calciphylaxis 15.84 10.27 50 383347 2588 50219139
Skin ulcer 15.83 10.27 181 383216 35137 50186590
Isosthenuria 15.77 10.27 10 383387 99 50221628
Cervix neoplasm 15.68 10.27 13 383384 201 50221526
Ketoacidosis 15.63 10.27 5 383392 3890 50217837
Blood parathyroid hormone abnormal 15.63 10.27 13 383384 202 50221525
Leukoencephalopathy 15.56 10.27 5 383392 3878 50217849
Gastric volvulus 15.56 10.27 5 383392 6 50221721
Vestibular migraine 15.53 10.27 13 383384 204 50221523
Pancreatitis acute 15.50 10.27 111 383286 23701 50198026
Cardiac disorder 15.48 10.27 431 382966 42548 50179179
Compression fracture 15.42 10.27 86 383311 5751 50215976
Acne 15.39 10.27 221 383176 19374 50202353
Dermatitis exfoliative 15.36 10.27 10 383387 5132 50216595
Encephalitis 15.35 10.27 20 383377 7360 50214367
Post procedural stroke 15.27 10.27 8 383389 53 50221674
Eye pain 15.07 10.27 301 383096 28148 50193579
Hypothermia 15.05 10.27 44 383353 11972 50209755
Red blood cell count increased 15.01 10.27 49 383348 2582 50219145
Purpura 14.96 10.27 33 383364 9878 50211849
Blood pressure systolic abnormal 14.91 10.27 22 383375 7684 50214043
Spinal pain 14.91 10.27 136 383261 10667 50211060
Ileus paralytic 14.89 10.27 6 383391 4044 50217683
Stress cardiomyopathy 14.80 10.27 23 383374 7864 50213863
Epilepsy 14.80 10.27 99 383298 21468 50200259
Road traffic accident 14.74 10.27 263 383134 24089 50197638
Hypersomnia 14.64 10.27 179 383218 15135 50206592
Abnormal behaviour 14.64 10.27 88 383309 19570 50202157
Arthropod bite 14.63 10.27 87 383310 5958 50215769
Increased appetite 14.61 10.27 111 383286 8250 50213477
Galactorrhoea 14.56 10.27 5 383392 3718 50218009
Anal incontinence 14.54 10.27 142 383255 11348 50210379
Blood urine present 14.52 10.27 155 383242 12678 50209049
Gingival recession 14.49 10.27 31 383366 1263 50220464
Central obesity 14.47 10.27 27 383370 995 50220732
Schizophrenia 14.43 10.27 21 383376 7376 50214351
Rebound effect 14.41 10.27 55 383342 3134 50218593
Product complaint 14.35 10.27 42 383355 11424 50210303
Nephrectomy 14.33 10.27 24 383373 811 50220916
Blood thyroid stimulating hormone increased 14.31 10.27 87 383310 6005 50215722
Cytomegalovirus viraemia 14.28 10.27 9 383388 4700 50217027
Impaired healing 14.22 10.27 411 382986 69375 50152352
Gout 14.15 10.27 141 383256 11329 50210398
Transplant dysfunction 14.14 10.27 9 383388 4675 50217052
Monocyte percentage increased 14.12 10.27 27 383370 1014 50220713
Paradoxical drug reaction 14.08 10.27 5 383392 3642 50218085
Clonus 14.07 10.27 7 383390 4168 50217559
Upper respiratory tract infection 14.00 10.27 622 382775 65276 50156451
Sinus bradycardia 13.94 10.27 52 383345 13131 50208596
Musculoskeletal chest pain 13.93 10.27 207 383190 18279 50203448
Mucous stools 13.90 10.27 51 383346 2851 50218876
Torus fracture 13.82 10.27 10 383387 125 50221602
Substance abuse 13.77 10.27 7 383390 4117 50217610
Injection site rash 13.74 10.27 185 383212 15992 50205735
Intervertebral disc protrusion 13.71 10.27 224 383173 20169 50201558
Temperature intolerance 13.69 10.27 101 383296 7438 50214289
Sinus headache 13.69 10.27 70 383327 4528 50217199
Feeling cold 13.68 10.27 216 383181 19315 50202412
Bladder disorder 13.67 10.27 101 383296 7442 50214285
Neoplasm progression 13.66 10.27 303 383094 28854 50192873
Swollen joint count increased 13.64 10.27 62 383335 14811 50206916
Tumour lysis syndrome 13.58 10.27 22 383375 7399 50214328
Pregnancy with contraceptive device 13.51 10.27 7 383390 4072 50217655
Nephrogenic systemic fibrosis 13.47 10.27 8 383389 4314 50217413
Skin necrosis 13.46 10.27 40 383357 10827 50210900
Enterocolitis 13.45 10.27 18 383379 6549 50215178
Anti-transglutaminase antibody increased 13.35 10.27 4 383393 3 50221724
Colonoscopy 13.34 10.27 31 383366 1336 50220391
Myopathy 13.33 10.27 31 383366 9108 50212619
Rotator cuff syndrome 13.33 10.27 140 383257 11404 50210323
Pancreatic enlargement 13.29 10.27 7 383390 47 50221680
Ventricular septal defect 13.29 10.27 7 383390 4034 50217693
Hypernatraemia 13.28 10.27 17 383380 6304 50215423
Gastroenteritis viral 13.25 10.27 208 383189 18578 50203149
Electrolyte imbalance 13.24 10.27 76 383321 17093 50204634
Skin sensitisation 13.18 10.27 22 383375 741 50220986
Head banging 13.18 10.27 16 383381 399 50221328
Joint swelling 13.17 10.27 1642 381755 243644 49978083
Haemolytic anaemia 13.17 10.27 32 383365 9260 50212467
Full blood count increased 13.10 10.27 24 383373 872 50220855
Gastric ulcer 13.06 10.27 101 383296 21204 50200523
Catatonia 13.00 10.27 6 383391 3730 50217997
Gastrointestinal inflammation 12.98 10.27 69 383328 4531 50217196
Granuloma skin 12.91 10.27 15 383382 5803 50215924
Collagen-vascular disease 12.89 10.27 8 383389 76 50221651
Exostosis 12.84 10.27 140 383257 11513 50210214
Adenovirus infection 12.84 10.27 4 383393 3164 50218563
Electrocardiogram PR shortened 12.81 10.27 12 383385 220 50221507
Ankle deformity 12.78 10.27 16 383381 412 50221315
Atypical fracture 12.75 10.27 19 383378 580 50221147
Pleural thickening 12.72 10.27 46 383351 2553 50219174
Hypercalciuria 12.72 10.27 12 383385 222 50221505
Drug withdrawal syndrome 12.67 10.27 125 383272 24956 50196771
Activated partial thromboplastin time prolonged 12.66 10.27 18 383379 6384 50215343
Presbyacusis 12.64 10.27 48 383349 2728 50218999
Large intestine polyp 12.62 10.27 97 383300 7235 50214492
Radius fracture 12.62 10.27 53 383344 3156 50218571
Cardiovascular disorder 12.58 10.27 39 383358 10415 50211312
Drug screen positive 12.58 10.27 5 383392 3397 50218330
Oligohydramnios 12.57 10.27 15 383382 5735 50215992
Duodenal ulcer 12.48 10.27 20 383377 6755 50214972
Toxic encephalopathy 12.48 10.27 14 383383 5501 50216226
Live birth 12.46 10.27 73 383324 16335 50205392
Infusion site swelling 12.39 10.27 95 383302 7081 50214646
Invasive lobular breast carcinoma 12.39 10.27 20 383377 655 50221072
Skin exfoliation 12.37 10.27 338 383059 33274 50188453
Exposure via ingestion 12.37 10.27 3 383394 2800 50218927
Optic neuritis 12.34 10.27 92 383305 6798 50214929
Hereditary angioedema 12.33 10.27 77 383320 5365 50216362
Hypogammaglobulinaemia 12.32 10.27 15 383382 5684 50216043
Arthritis 12.29 10.27 788 382609 85933 50135794
Lymph node pain 12.24 10.27 29 383368 1266 50220461
Product dose omission in error 12.19 10.27 43 383354 2357 50219370
Facial pain 12.19 10.27 99 383298 7510 50214217
Neutralising antibodies positive 12.17 10.27 12 383385 235 50221492
Aplastic anaemia 12.17 10.27 25 383372 7678 50214049
Forearm fracture 12.09 10.27 16 383381 436 50221291
Hyperpyrexia 12.09 10.27 4 383393 3045 50218682
Fibula fracture 12.04 10.27 50 383347 2962 50218765
Urine ketone body present 12.03 10.27 42 383355 2291 50219436
Metastases to lung 11.96 10.27 43 383354 10977 50210750
Anorectal stenosis 11.96 10.27 5 383392 18 50221709
Eye disorder 11.93 10.27 204 383193 18535 50203192
Face injury 11.92 10.27 47 383350 2719 50219008
Tubulointerstitial nephritis 11.91 10.27 67 383330 15144 50206583
Varicella virus test positive 11.90 10.27 9 383388 121 50221606
Pleural fibrosis 11.86 10.27 54 383343 3330 50218397
Pulseless electrical activity 11.86 10.27 21 383376 6820 50214907
Bone cyst 11.82 10.27 38 383359 1986 50219741
Cardiac flutter 11.81 10.27 54 383343 3336 50218391
Immunoglobulins increased 11.80 10.27 13 383384 291 50221436
Pneumonitis 11.80 10.27 155 383242 29355 50192372
Hepatomegaly 11.79 10.27 42 383355 10751 50210976
Muscle strain 11.78 10.27 93 383304 6995 50214732
Body temperature decreased 11.74 10.27 182 383215 16213 50205514
Viral infection 11.74 10.27 304 383093 29682 50192045
Erysipelas 11.71 10.27 20 383377 6588 50215139
Cardiac failure congestive 11.71 10.27 521 382876 83861 50137866
Radical mastectomy 11.67 10.27 3 383394 0 50221727
Adenosquamous cell lung cancer stage IV 11.67 10.27 3 383394 0 50221727
Incarcerated inguinal hernia 11.67 10.27 3 383394 0 50221727
Vitamin A deficiency 11.67 10.27 3 383394 0 50221727
Peripheral sensory neuropathy 11.64 10.27 20 383377 6571 50215156
Tonsillectomy 11.63 10.27 21 383376 754 50220973
Poor quality sleep 11.62 10.27 184 383213 16462 50205265
Rash pruritic 11.62 10.27 458 382939 47388 50174339
Nocturia 11.57 10.27 89 383308 6641 50215086
Pallor 11.56 10.27 116 383281 23083 50198644
Genital haemorrhage 11.56 10.27 20 383377 6554 50215173
Hepatic encephalopathy 11.55 10.27 36 383361 9600 50212127
Oesophageal discomfort 11.53 10.27 10 383387 165 50221562
Carbohydrate antigen 125 increased 11.52 10.27 43 383354 2424 50219303
Type 2 diabetes mellitus 11.50 10.27 187 383210 34188 50187539
Bradyphrenia 11.49 10.27 18 383379 6134 50215593
Weight bearing difficulty 11.47 10.27 41 383356 2263 50219464
Thyroid cancer 11.40 10.27 62 383335 4107 50217620
Neonatal respiratory distress syndrome 11.40 10.27 3 383394 2651 50219076
Right ventricular failure 11.39 10.27 72 383325 15821 50205906
Hypertonic bladder 11.37 10.27 49 383348 2951 50218776
Faeces soft 11.35 10.27 61 383336 4023 50217704
Lactose intolerance 11.34 10.27 44 383353 2526 50219201
Metabolic disorder 11.34 10.27 14 383383 5272 50216455
Blood 25-hydroxycholecalciferol decreased 11.32 10.27 7 383390 66 50221661
Upper gastrointestinal haemorrhage 11.31 10.27 73 383324 15962 50205765
Jaw disorder 11.24 10.27 70 383327 4873 50216854
Hysterectomy 11.23 10.27 100 383297 7790 50213937
Renal tubular dysfunction 11.23 10.27 14 383383 359 50221368
Product prescribing error 11.22 10.27 103 383294 20858 50200869
Pyelitis 11.19 10.27 10 383387 172 50221555
Osteosclerosis 11.18 10.27 54 383343 3413 50218314
Vaginal haematoma 11.14 10.27 9 383388 134 50221593
Thyroxine decreased 11.14 10.27 16 383381 472 50221255
Thyroxine free increased 11.14 10.27 21 383376 780 50220947
Psychomotor retardation 11.12 10.27 6 383391 3412 50218315
Unresponsive to stimuli 11.09 10.27 164 383233 30445 50191282
Glomerular filtration rate decreased 11.06 10.27 136 383261 11516 50210211
Skin burning sensation 11.05 10.27 122 383275 10063 50211664
Cervical vertebral fracture 11.03 10.27 39 383358 2141 50219586
Adrenal insufficiency 11.01 10.27 63 383334 14180 50207547
Tachypnoea 10.99 10.27 65 383332 14512 50207215
Tenosynovitis 10.96 10.27 42 383355 10523 50211204
Osteogenesis imperfecta 10.93 10.27 13 383384 317 50221410
Fungal infection 10.93 10.27 301 383096 29664 50192063
Cervical spinal stenosis 10.92 10.27 36 383361 1907 50219820
Feeling jittery 10.91 10.27 131 383266 11029 50210698
Red blood cell sedimentation rate increased 10.87 10.27 157 383240 29259 50192468
Aphonia 10.84 10.27 105 383292 8373 50213354
Diabetic ketoacidosis 10.83 10.27 85 383312 17787 50203940
Pulmonary oedema 10.80 10.27 285 383112 48653 50173074
Fracture nonunion 10.78 10.27 39 383358 2165 50219562
Wheezing 10.74 10.27 574 382823 61473 50160254
Disseminated tuberculosis 10.71 10.27 3 383394 2543 50219184
Viral upper respiratory tract infection 10.66 10.27 90 383307 6906 50214821
Immunosuppressant drug level increased 10.65 10.27 5 383392 3077 50218650
Pancreatic neuroendocrine tumour 10.64 10.27 12 383385 276 50221451
Tandem gait test abnormal 10.63 10.27 4 383393 10 50221717
Myelodysplastic syndrome 10.61 10.27 69 383328 15063 50206664
Meralgia paraesthetica 10.61 10.27 9 383388 144 50221583
Drug use disorder 10.59 10.27 5 383392 3067 50218660
C-telopeptide increased 10.53 10.27 5 383392 26 50221701
Proteinuria 10.50 10.27 78 383319 16519 50205208
Blood albumin abnormal 10.45 10.27 15 383382 442 50221285
Head injury 10.44 10.27 247 383150 23773 50197954
Congestive cardiomyopathy 10.44 10.27 16 383381 5502 50216225
Gingival disorder 10.40 10.27 50 383347 3155 50218572
Acidosis 10.39 10.27 41 383356 10186 50211541
Mean cell volume abnormal 10.38 10.27 13 383384 335 50221392
Cheilosis 10.36 10.27 4 383393 11 50221716
Enzyme level decreased 10.36 10.27 4 383393 11 50221716
Vein disorder 10.35 10.27 62 383335 4257 50217470
Product monitoring error 10.32 10.27 4 383393 2760 50218967
Dairy intolerance 10.32 10.27 6 383391 50 50221677
Physiotherapy 10.32 10.27 6 383391 50 50221677
Heart rate irregular 10.31 10.27 205 383192 19155 50202572

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Fatigue 416.42 10.33 2679 133201 314142 29124505
Toxicity to various agents 374.32 10.33 165 135715 173496 29265151
Drug interaction 301.64 10.33 278 135602 197107 29241540
Completed suicide 235.28 10.33 62 135818 90184 29348463
Drug abuse 230.07 10.33 44 135836 79839 29358808
Product dose omission issue 228.17 10.33 962 134918 95421 29343226
Multiple sclerosis relapse 202.39 10.33 256 135624 11163 29427484
Acute kidney injury 164.55 10.33 645 135235 264622 29174025
Infective pulmonary exacerbation of cystic fibrosis 150.84 10.33 164 135716 6072 29432575
Interstitial lung disease 128.64 10.33 52 135828 57666 29380981
Overdose 126.95 10.33 108 135772 79711 29358936
Hepatic function abnormal 116.48 10.33 20 135860 39239 29399408
Intentional overdose 115.70 10.33 19 135861 38509 29400138
Fall 106.54 10.33 1263 134617 175915 29262732
Multiple organ dysfunction syndrome 104.57 10.33 82 135798 63034 29375613
Peripheral swelling 102.74 10.33 570 135310 63169 29375478
Muscle spasms 98.96 10.33 573 135307 64509 29374138
Plasma cell myeloma 97.60 10.33 383 135497 36732 29401915
Coma 95.59 10.33 31 135849 39419 29399228
Multiple sclerosis 91.32 10.33 120 135760 5434 29433213
Back pain 89.62 10.33 788 135092 101496 29337151
Sinusitis 85.13 10.33 348 135532 34002 29404645
Vitamin D deficiency 84.09 10.33 115 135765 5414 29433233
Cardiac failure 83.15 10.33 148 135732 79139 29359508
Balance disorder 82.30 10.33 357 135523 35813 29402834
Thrombocytopenia 81.94 10.33 330 135550 134493 29304154
Memory impairment 77.72 10.33 353 135527 36117 29402530
Suicide attempt 77.18 10.33 30 135850 34080 29404567
Diarrhoea 77.16 10.33 2036 133844 330662 29107985
Febrile neutropenia 74.49 10.33 265 135615 111975 29326672
Constipation 74.42 10.33 827 135053 113333 29325314
Rhabdomyolysis 72.72 10.33 104 135776 60704 29377943
Influenza 72.50 10.33 382 135498 41499 29397148
Cardio-respiratory arrest 70.49 10.33 77 135803 50524 29388123
Weight decreased 70.24 10.33 1027 134853 149878 29288769
Full blood count decreased 68.86 10.33 195 135685 15797 29422850
Feeling abnormal 63.95 10.33 449 135431 53996 29384651
Drug reaction with eosinophilia and systemic symptoms 62.70 10.33 25 135855 27967 29410680
Nasopharyngitis 60.94 10.33 476 135404 59189 29379458
Hyperkalaemia 59.60 10.33 120 135760 61272 29377375
Adverse drug reaction 59.23 10.33 243 135637 23777 29414870
Neuropathy peripheral 57.97 10.33 539 135341 70488 29368159
Gait disturbance 57.56 10.33 552 135328 72797 29365850
Cytomegalovirus infection 56.66 10.33 18 135862 23197 29415450
Septic shock 55.98 10.33 128 135752 62432 29376215
Neuroleptic malignant syndrome 55.72 10.33 5 135875 16143 29422504
Cardiac arrest 55.49 10.33 204 135676 85387 29353260
Asthenia 54.64 10.33 1334 134546 213916 29224731
Hepatocellular injury 54.53 10.33 15 135865 21228 29417419
Toxic epidermal necrolysis 54.39 10.33 9 135871 18144 29420503
Cholestasis 54.13 10.33 20 135860 23442 29415205
Muscle spasticity 53.36 10.33 87 135793 4796 29433851
Altered state of consciousness 53.05 10.33 13 135867 19876 29418771
Pain 51.46 10.33 1088 134792 170344 29268303
Neutropenia 51.37 10.33 374 135506 131337 29307310
Hypotension 50.80 10.33 610 135270 193744 29244903
Pain in extremity 50.31 10.33 749 135131 109684 29328963
Prostatic specific antigen increased 50.05 10.33 149 135731 12415 29426232
Disseminated intravascular coagulation 49.65 10.33 15 135865 19965 29418682
Serotonin syndrome 49.63 10.33 10 135870 17502 29421145
Hypoaesthesia 49.42 10.33 417 135463 53050 29385597
Mucosal inflammation 48.68 10.33 44 135836 31551 29407096
Arthralgia 48.55 10.33 906 134974 138711 29299936
Relapsing-remitting multiple sclerosis 48.03 10.33 34 135846 698 29437949
Lactic acidosis 47.96 10.33 41 135839 30206 29408441
Depressed level of consciousness 47.38 10.33 60 135820 36882 29401765
Angioedema 47.34 10.33 46 135834 31869 29406778
Hyponatraemia 47.33 10.33 156 135724 67477 29371170
Shock 46.51 10.33 20 135860 21384 29417263
Electrocardiogram QT prolonged 46.03 10.33 59 135821 36078 29402569
Abdominal discomfort 45.55 10.33 376 135504 47527 29391120
Hip fracture 45.23 10.33 128 135752 10364 29428283
Gait spastic 45.16 10.33 32 135848 658 29437989
Myelosuppression 44.40 10.33 3 135877 12224 29426423
Agranulocytosis 44.21 10.33 19 135861 20321 29418326
General physical health deterioration 44.09 10.33 284 135596 102573 29336074
Drug resistance 43.91 10.33 22 135858 21518 29417129
Leukopenia 43.89 10.33 120 135760 55083 29383564
Influenza like illness 42.89 10.33 224 135656 24246 29414401
Insomnia 42.78 10.33 608 135272 88153 29350494
Rash maculo-papular 42.21 10.33 30 135850 24259 29414388
Headache 41.02 10.33 1068 134812 172939 29265708
Blood creatine phosphokinase increased 40.69 10.33 78 135802 40566 29398081
Spinal fracture 40.40 10.33 91 135789 6395 29432252
Inappropriate schedule of product administration 40.12 10.33 345 135535 44127 29394520
Full blood count abnormal 39.50 10.33 155 135725 14858 29423789
Sleep apnoea syndrome 39.47 10.33 173 135707 17426 29421221
Laboratory test abnormal 39.46 10.33 177 135703 18008 29420639
Renal failure 39.22 10.33 352 135528 118247 29320400
Blood pressure fluctuation 39.02 10.33 188 135692 19706 29418941
Circulatory collapse 38.17 10.33 19 135861 18654 29419993
Seasonal allergy 38.03 10.33 77 135803 5025 29433622
Hepatic failure 37.56 10.33 54 135826 31458 29407189
Heart rate decreased 36.95 10.33 218 135662 24694 29413953
Cough 36.92 10.33 801 135079 125926 29312721
Thrombosis 36.28 10.33 329 135551 42716 29395931
Frequent bowel movements 36.26 10.33 109 135771 9130 29429517
Body height decreased 35.73 10.33 60 135820 3390 29435257
Rhinorrhoea 35.67 10.33 194 135686 21325 29417322
Hypoglycaemia 35.58 10.33 109 135771 48237 29390410
Respiratory distress 35.40 10.33 58 135822 32048 29406599
Needle fatigue 35.10 10.33 26 135854 574 29438073
Vitamin D decreased 34.55 10.33 54 135826 2871 29435776
Metabolic acidosis 34.54 10.33 76 135804 37586 29401061
Pancytopenia 34.43 10.33 232 135648 82936 29355711
Cystic fibrosis 33.94 10.33 38 135842 1454 29437193
Cerebral infarction 33.85 10.33 38 135842 24637 29414010
Colitis ulcerative 33.73 10.33 132 135748 12637 29426010
Hepatitis 33.15 10.33 28 135852 20755 29417892
Respiratory failure 33.11 10.33 286 135594 96845 29341802
Foetal exposure during pregnancy 33.03 10.33 66 135814 33801 29404846
Central nervous system lesion 32.71 10.33 77 135803 5571 29433076
Gamma-glutamyltransferase increased 32.67 10.33 45 135835 26692 29411955
Hospitalisation 32.62 10.33 339 135541 45649 29392998
Bowel movement irregularity 32.54 10.33 47 135833 2329 29436318
Hot flush 32.46 10.33 145 135735 14725 29423922
Bone giant cell tumour 32.35 10.33 10 135870 22 29438625
Osteoporosis 32.33 10.33 116 135764 10653 29427994
Melaena 31.93 10.33 59 135821 31117 29407530
Hypervitaminosis D 31.88 10.33 8 135872 4 29438643
Acute respiratory distress syndrome 31.82 10.33 35 135845 22900 29415747
Product use in unapproved indication 31.80 10.33 251 135629 86624 29352023
Bone marrow failure 31.77 10.33 48 135832 27401 29411246
Pyrexia 31.47 10.33 1045 134835 286577 29152070
Pulmonary function test decreased 31.23 10.33 63 135817 4100 29434547
Toxic skin eruption 31.17 10.33 4 135876 9753 29428894
White blood cell count decreased 31.06 10.33 547 135333 82815 29355832
Respiratory arrest 31.05 10.33 44 135836 25789 29412858
C-reactive protein increased 31.02 10.33 102 135778 44161 29394486
Nephrolithiasis 30.94 10.33 211 135669 25123 29413524
Jaundice 30.40 10.33 55 135825 29241 29409406
Bone density decreased 30.29 10.33 38 135842 1642 29437005
Anuria 30.27 10.33 4 135876 9537 29429110
Dizziness 30.22 10.33 1110 134770 188574 29250073
Psoriasis 30.11 10.33 252 135628 31975 29406672
Ageusia 30.08 10.33 100 135780 8838 29429809
Hepatotoxicity 29.84 10.33 23 135857 17844 29420803
Intentional self-injury 29.81 10.33 10 135870 12451 29426196
Hyperthermia 29.80 10.33 4 135876 9426 29429221
Bradycardia 29.77 10.33 178 135702 65451 29373196
Hernia 29.46 10.33 95 135785 8263 29430384
Anaphylactic reaction 29.30 10.33 51 135829 27522 29411125
Cardiogenic shock 29.23 10.33 27 135853 19163 29419484
Stevens-Johnson syndrome 29.16 10.33 20 135860 16477 29422170
Tachycardia 28.98 10.33 204 135676 72206 29366441
Cataract 28.91 10.33 189 135691 22189 29416458
Renal impairment 28.84 10.33 237 135643 81096 29357551
Alanine aminotransferase increased 28.82 10.33 199 135681 70745 29367902
Vitamin D increased 28.81 10.33 11 135869 55 29438592
Hypersomnia 28.27 10.33 111 135769 10643 29428004
Anaphylactic shock 28.13 10.33 13 135867 13323 29425324
Premature baby 27.91 10.33 23 135857 17257 29421390
Blood bilirubin increased 27.44 10.33 73 135807 33820 29404827
Extrapyramidal disorder 27.15 10.33 8 135872 10823 29427824
Mobility decreased 27.04 10.33 207 135673 25573 29413074
Labelled drug-drug interaction medication error 27.00 10.33 11 135869 12148 29426499
Neurotoxicity 26.80 10.33 17 135863 14596 29424051
Delirium 26.78 10.33 92 135788 39305 29399342
Muscular weakness 26.73 10.33 417 135463 61635 29377012
Ascites 26.63 10.33 83 135797 36536 29402111
Weight increased 26.42 10.33 497 135383 76170 29362477
Hypertonic bladder 26.36 10.33 33 135847 1423 29437224
Exposure during pregnancy 26.17 10.33 4 135876 8550 29430097
Myocardial infarction 25.85 10.33 354 135526 109942 29328705
Pollakiuria 25.71 10.33 149 135731 16767 29421880
Gait inability 25.47 10.33 158 135722 18217 29420430
Upper limb fracture 25.41 10.33 57 135823 3994 29434653
Contusion 25.35 10.33 236 135644 30859 29407788
Pneumocystis jirovecii pneumonia 25.10 10.33 24 135856 16755 29421892
Aspartate aminotransferase increased 25.01 10.33 166 135714 59559 29379088
Musculoskeletal stiffness 24.64 10.33 272 135608 37186 29401461
Epilepsy 24.62 10.33 29 135851 18403 29420244
Treatment failure 24.61 10.33 87 135793 36852 29401795
Cerebral haemorrhage 24.46 10.33 69 135811 31357 29407290
Flatulence 24.37 10.33 152 135728 17557 29421090
Bronchial wall thickening 24.28 10.33 27 135853 1025 29437622
Intentional dose omission 24.21 10.33 38 135842 2028 29436619
Hyperbilirubinaemia 23.97 10.33 20 135860 14914 29423733
Miosis 23.93 10.33 4 135876 8005 29430642
Blood 25-hydroxycholecalciferol increased 23.91 10.33 6 135874 3 29438644
Nephrocalcinosis 23.87 10.33 20 135860 531 29438116
Limb discomfort 23.74 10.33 97 135783 9471 29429176
Paraesthesia 23.63 10.33 363 135517 53482 29385165
Upper respiratory tract infection 23.53 10.33 210 135670 27139 29411508
Gastrointestinal disorder 23.47 10.33 218 135662 28488 29410159
Squamous cell carcinoma of skin 23.40 10.33 96 135784 9390 29429257
Red blood cell count decreased 23.28 10.33 199 135681 25403 29413244
Ventricular fibrillation 23.27 10.33 23 135857 15810 29422837
Dyspepsia 23.25 10.33 226 135654 29899 29408748
Accidental overdose 23.16 10.33 28 135852 17565 29421082
Liver function test abnormal 22.87 10.33 63 135817 28855 29409792
Blood lactate dehydrogenase increased 22.80 10.33 33 135847 19176 29419471
Rib fracture 22.68 10.33 117 135763 12601 29426046
Angina pectoris 22.53 10.33 60 135820 27790 29410857
Anaemia 22.42 10.33 728 135152 200223 29238424
Neutropenic sepsis 22.40 10.33 13 135867 11714 29426933
Status epilepticus 22.03 10.33 11 135869 10783 29427864
Upper-airway cough syndrome 22.00 10.33 45 135835 2958 29435689
Nephropathy toxic 21.90 10.33 11 135869 10745 29427902
Blood parathyroid hormone increased 21.85 10.33 29 135851 1326 29437321
Agitation 21.78 10.33 142 135738 51162 29387485
Hepatitis cholestatic 21.60 10.33 3 135877 6890 29431757
International normalised ratio increased 21.37 10.33 118 135762 44254 29394393
Fractional exhaled nitric oxide increased 21.34 10.33 16 135864 360 29438287
Pulmonary haemorrhage 21.22 10.33 8 135872 9262 29429385
Hypercalcaemia 21.12 10.33 115 135765 12644 29426003
Hypercalciuria 20.94 10.33 14 135866 261 29438386
Polydactyly 20.90 10.33 26 135854 1114 29437533
Bronchial secretion retention 20.66 10.33 26 135854 1127 29437520
Torsade de pointes 20.64 10.33 3 135877 6658 29431989
Hypocalcaemia 20.60 10.33 164 135716 20501 29418146
Dysgeusia 20.49 10.33 176 135704 22498 29416149
Acute hepatic failure 20.45 10.33 15 135865 11937 29426710
Blood pressure increased 20.35 10.33 463 135417 73340 29365307
Oropharyngeal pain 20.35 10.33 215 135665 29070 29409577
Micturition urgency 20.27 10.33 61 135819 5112 29433535
Heart rate irregular 20.24 10.33 116 135764 13001 29425646
Haemodynamic instability 20.17 10.33 6 135874 8067 29430580
Nocturia 20.14 10.33 84 135796 8278 29430369
Plasma cell myeloma recurrent 20.02 10.33 49 135831 3634 29435013
Aspergillus infection 19.83 10.33 12 135868 10569 29428078
Urinary tract infection 19.67 10.33 453 135427 71901 29366746
Haemophagocytic lymphohistiocytosis 19.57 10.33 12 135868 10492 29428155
Flushing 19.28 10.33 211 135669 28781 29409866
Blood testosterone decreased 18.99 10.33 50 135830 3880 29434767
Vomiting 18.95 10.33 790 135090 211470 29227177
Akathisia 18.79 10.33 4 135876 6738 29431909
Dyspnoea exertional 18.79 10.33 253 135627 36237 29402410
Acne 18.71 10.33 88 135792 9132 29429515
Tooth disorder 18.64 10.33 90 135790 9439 29429208
Dry skin 18.55 10.33 176 135704 23131 29415516
Haematemesis 18.48 10.33 55 135825 24571 29414076
Viral infection 18.47 10.33 124 135756 14686 29423961
Inappropriate antidiuretic hormone secretion 18.35 10.33 14 135866 10918 29427729
Productive cough 18.33 10.33 222 135658 31037 29407610
Monoparesis 18.26 10.33 32 135848 1871 29436776
Joint swelling 18.23 10.33 325 135555 49305 29389342
Cytokine release syndrome 18.22 10.33 20 135860 13099 29425548
Transaminases increased 18.20 10.33 49 135831 22613 29416034
Renal disorder 18.17 10.33 171 135709 22424 29416223
Osteopenia 18.11 10.33 51 135829 4117 29434530
Aplastic anaemia 18.01 10.33 6 135874 7504 29431143
Arthritis 18.00 10.33 185 135695 24834 29413813
Sudden death 18.00 10.33 23 135857 14087 29424560
Hypokalaemia 17.91 10.33 146 135734 50057 29388590
Joint lock 17.90 10.33 24 135856 1108 29437539
Hypertriglyceridaemia 17.88 10.33 6 135874 7469 29431178
Eosinophilia 17.73 10.33 48 135832 22113 29416534
Clostridium difficile infection 17.71 10.33 131 135749 16010 29422637
Haemodialysis 17.68 10.33 12 135868 9942 29428705
Hepatitis acute 17.67 10.33 4 135876 6458 29432189
Myocardial ischaemia 17.62 10.33 29 135851 15999 29422648
Neck pain 17.59 10.33 163 135717 21284 29417363
Renal tubular necrosis 17.58 10.33 24 135856 14291 29424356
Skin cancer 17.31 10.33 81 135799 8387 29430260
Nasal congestion 17.30 10.33 147 135733 18732 29419915
JC polyomavirus test positive 17.27 10.33 17 135863 559 29438088
Acute graft versus host disease 17.20 10.33 3 135877 5821 29432826
Pleural thickening 17.13 10.33 13 135867 298 29438349
Abdominal distension 16.99 10.33 301 135579 45610 29393037
Pathogen resistance 16.98 10.33 8 135872 8108 29430539
Intervertebral disc degeneration 16.92 10.33 58 135822 5206 29433441
Drug eruption 16.86 10.33 32 135848 16709 29421938
Acute myocardial infarction 16.77 10.33 142 135738 48296 29390351
Liver disorder 16.76 10.33 68 135812 27681 29410966
Myoclonus 16.66 10.33 22 135858 13287 29425360
Epstein-Barr virus infection 16.43 10.33 5 135875 6624 29432023
Dysstasia 16.40 10.33 93 135787 10381 29428266
Tumour lysis syndrome 16.34 10.33 24 135856 13860 29424787
Pulmonary oedema 16.31 10.33 122 135758 42613 29396034
Therapy interrupted 16.26 10.33 79 135801 8307 29430340
Rash 16.21 10.33 1045 134835 188774 29249873
Medication error 16.19 10.33 47 135833 21164 29417483
Urine leukocyte esterase positive 16.11 10.33 14 135866 391 29438256
Hordeolum 16.08 10.33 19 135861 771 29437876
Blood calcium decreased 16.05 10.33 84 135796 9098 29429549
Bone pain 16.03 10.33 142 135738 18310 29420337
Back disorder 15.98 10.33 62 135818 5911 29432736
Osteonecrosis of jaw 15.90 10.33 130 135750 16380 29422267
Cyanosis 15.84 10.33 17 135863 11250 29427397
Weight fluctuation 15.84 10.33 48 135832 4038 29434609
Growth hormone deficiency 15.83 10.33 11 135869 219 29438428
Localised infection 15.65 10.33 113 135767 13703 29424944
Gastrooesophageal reflux disease 15.65 10.33 217 135663 31279 29407368
Hyperglycaemia 15.53 10.33 93 135787 34194 29404453
Hyperexplexia 15.40 10.33 6 135874 32 29438615
Nerve degeneration 15.31 10.33 10 135870 179 29438468
Aggression 15.27 10.33 98 135782 35443 29403204
Sedation 15.24 10.33 36 135844 17369 29421278
Blood potassium decreased 15.21 10.33 124 135756 15610 29423037
Ankylosing spondylitis 15.21 10.33 48 135832 4128 29434519
Intentional product use issue 15.15 10.33 277 135603 42221 29396426
Eosinophil percentage increased 15.14 10.33 15 135865 497 29438150
Shock haemorrhagic 15.07 10.33 13 135867 9538 29429109
Cellulitis 15.04 10.33 295 135585 45545 29393102
Lung hernia 14.98 10.33 7 135873 62 29438585
Cardiovascular somatic symptom disorder 14.96 10.33 6 135874 35 29438612
Increased tendency to bruise 14.91 10.33 43 135837 3519 29435128
Milk-alkali syndrome 14.90 10.33 15 135865 507 29438140
Migraine 14.86 10.33 103 135777 12327 29426320
Bronchopulmonary aspergillosis 14.86 10.33 21 135859 12323 29426324
Blood test abnormal 14.83 10.33 59 135821 5690 29432957
Obstructive airways disorder 14.81 10.33 94 135786 10922 29427725
Multiple allergies 14.81 10.33 31 135849 2071 29436576
C-reactive protein decreased 14.78 10.33 26 135854 1525 29437122
Thrombotic microangiopathy 14.72 10.33 11 135869 8670 29429977
Hospice care 14.71 10.33 54 135826 5014 29433633
Pleural effusion 14.69 10.33 237 135643 71671 29366976
Nonspecific reaction 14.65 10.33 22 135858 1129 29437518
Hypertensive crisis 14.57 10.33 9 135871 7839 29430808
Malignant neoplasm progression 14.57 10.33 245 135635 73614 29365033
Seborrhoeic keratosis 14.41 10.33 19 135861 863 29437784
Contraindicated product administered 14.29 10.33 40 135840 18226 29420421
Febrile bone marrow aplasia 14.26 10.33 8 135872 7343 29431304
Movement disorder 14.17 10.33 88 135792 10149 29428498
Unevaluable event 14.16 10.33 204 135676 29647 29409000
Erythema multiforme 14.12 10.33 9 135871 7708 29430939
Hypothermia 14.07 10.33 13 135867 9226 29429421
Dermatitis exfoliative 13.96 10.33 6 135874 6419 29432228
Cystic fibrosis respiratory infection suppression 13.93 10.33 10 135870 210 29438437
Atrioventricular septal defect 13.93 10.33 9 135871 158 29438489
Nail infection 13.89 10.33 10 135870 211 29438436
Heparin-induced thrombocytopenia 13.78 10.33 3 135877 4976 29433671
Musculoskeletal disorder 13.70 10.33 54 135826 5186 29433461
Bone marrow oedema 13.67 10.33 14 135866 483 29438164
Stomatitis 13.67 10.33 107 135773 37006 29401641
Ileal stenosis 13.57 10.33 22 135858 1207 29437440
Incorrect dose administered 13.57 10.33 220 135660 32764 29405883
Brain oedema 13.54 10.33 22 135858 12198 29426449
Drug level increased 13.36 10.33 43 135837 18744 29419903
Product use issue 13.34 10.33 320 135560 51124 29387523
Secondary progressive multiple sclerosis 13.32 10.33 12 135868 352 29438295
Vitamin B12 decreased 13.24 10.33 20 135860 1032 29437615
Cystitis haemorrhagic 13.24 10.33 3 135877 4839 29433808
Posterior reversible encephalopathy syndrome 13.24 10.33 13 135867 8963 29429684
Ventricular tachycardia 13.21 10.33 56 135824 22518 29416129
Hypervitaminosis 13.16 10.33 3 135877 0 29438647
Poor venous access 13.08 10.33 38 135842 3123 29435524
Polyp 13.05 10.33 38 135842 3127 29435520
Sphincter of Oddi dysfunction 13.02 10.33 8 135872 128 29438519
Bone scan abnormal 12.95 10.33 6 135874 52 29438595
Therapy cessation 12.93 10.33 112 135768 14350 29424297
Stress fracture 12.91 10.33 17 135863 771 29437876
Respiratory tract congestion 12.85 10.33 53 135827 5196 29433451
C-reactive protein abnormal 12.84 10.33 7 135873 6529 29432118
Tooth infection 12.84 10.33 55 135825 5484 29433163
Injection site pain 12.82 10.33 215 135665 32231 29406416
Full blood count increased 12.81 10.33 17 135863 777 29437870
Benign abdominal neoplasm 12.79 10.33 7 135873 89 29438558
Compression fracture 12.78 10.33 34 135846 2654 29435993
Hyperammonaemia 12.77 10.33 5 135875 5658 29432989
Prescribed underdose 12.77 10.33 70 135810 7716 29430931
Intentional product misuse 12.73 10.33 100 135780 34561 29404086
Bone density abnormal 12.57 10.33 6 135874 56 29438591
Bone cancer 12.50 10.33 21 135859 1187 29437460
Glossodynia 12.48 10.33 38 135842 3205 29435442
Polyneuropathy 12.44 10.33 23 135857 12129 29426518
Suicidal ideation 12.36 10.33 101 135779 34615 29404032
Accident at work 12.35 10.33 15 135865 627 29438020
Intestinal stenosis 12.33 10.33 27 135853 1861 29436786
Pulmonary alveolar haemorrhage 12.29 10.33 7 135873 6373 29432274
Pre-existing condition improved 12.28 10.33 30 135850 2223 29436424
Acute pulmonary oedema 12.27 10.33 8 135872 6771 29431876
Sleep disorder due to a general medical condition 12.23 10.33 37 135843 3109 29435538
Pulmonary mass 12.23 10.33 88 135792 10660 29427987
Metastatic renal cell carcinoma 12.20 10.33 27 135853 1875 29436772
Infected cyst 12.14 10.33 13 135867 473 29438174
Renal neoplasm 12.13 10.33 20 135860 1113 29437534
Sepsis 12.09 10.33 534 135346 142148 29296499
Chest expansion decreased 12.06 10.33 8 135872 147 29438500
Gastric haemorrhage 12.02 10.33 15 135865 9282 29429365
Burning sensation 12.02 10.33 119 135761 15819 29422828
Abdominal pain upper 11.99 10.33 366 135514 60627 29378020
Temperature intolerance 11.97 10.33 35 135845 2886 29435761
Concussion 11.96 10.33 28 135852 2018 29436629
Respiratory symptom 11.93 10.33 18 135862 928 29437719
Injection site erythema 11.92 10.33 107 135773 13849 29424798
Left ventricular dysfunction 11.89 10.33 14 135866 8888 29429759
Carcinoid tumour 11.87 10.33 9 135871 206 29438441
Product complaint 11.82 10.33 5 135875 5400 29433247
Colitis ischaemic 11.79 10.33 6 135874 5817 29432830
Drug ineffective 11.71 10.33 1476 134404 361694 29076953
Low birth weight baby 11.69 10.33 8 135872 6600 29432047
Gastroenteritis viral 11.64 10.33 55 135825 5717 29432930
Plantar fasciitis 11.60 10.33 21 135859 1260 29437387
Depression 11.58 10.33 490 135390 84657 29353990
Lower limb fracture 11.53 10.33 40 135840 3612 29435035
Hypophosphataemia 11.53 10.33 69 135811 7855 29430792
Secretion discharge 11.51 10.33 44 135836 4166 29434481
Asphyxia 11.49 10.33 5 135875 5310 29433337
Hepatic infection 11.41 10.33 13 135867 507 29438140
Skin burning sensation 11.40 10.33 40 135840 3633 29435014
Injection site nerve damage 11.39 10.33 4 135876 15 29438632
Vision blurred 11.37 10.33 253 135627 39923 29398724
Prostatomegaly 11.36 10.33 47 135833 4614 29434033
Loss of personal independence in daily activities 11.34 10.33 172 135708 25268 29413379
Drug-induced liver injury 11.32 10.33 56 135824 21599 29417048
Chest discomfort 11.31 10.33 284 135596 45699 29392948
Nasal polyps 11.22 10.33 25 135855 1744 29436903
Light chain analysis increased 11.20 10.33 19 135861 1082 29437565
Limbic encephalitis 11.19 10.33 11 135869 361 29438286
Emotional distress 11.19 10.33 30 135850 13865 29424782
Sensory disturbance 11.19 10.33 53 135827 5516 29433131
Fluid retention 11.17 10.33 161 135719 23399 29415248
Drug dependence 11.11 10.33 54 135826 20927 29417720
Adenoid cystic carcinoma 11.10 10.33 3 135877 3 29438644
Spirometry abnormal 11.07 10.33 11 135869 366 29438281
Monocyte percentage increased 10.99 10.33 17 135863 896 29437751
Faecal calprotectin increased 10.98 10.33 23 135857 1538 29437109
Cardiac disorder 10.97 10.33 236 135644 37027 29401620
Illness 10.94 10.33 60 135820 6614 29432033
Refusal of treatment by patient 10.83 10.33 4 135876 4690 29433957
Ear infection 10.82 10.33 69 135811 8031 29430616
Tubulointerstitial nephritis 10.80 10.33 43 135837 17600 29421047
Furuncle 10.76 10.33 34 135846 2925 29435722
Mite allergy 10.72 10.33 10 135870 307 29438340
Dysphonia 10.68 10.33 135 135745 19061 29419586
Head injury 10.67 10.33 117 135763 15964 29422683
Therapeutic product effect incomplete 10.65 10.33 246 135634 39059 29399588
Hepatitis B 10.63 10.33 6 135874 5491 29433156
Fear 10.63 10.33 17 135863 9487 29429160
Conjunctivitis allergic 10.62 10.33 14 135866 636 29438011
Pancreatitis acute 10.60 10.33 67 135813 24318 29414329
Pneumonia 10.59 10.33 1650 134230 318522 29120125
Therapeutic response unexpected 10.58 10.33 72 135808 8566 29430081
Night sweats 10.54 10.33 110 135770 14822 29423825
Hypoacusis 10.54 10.33 107 135773 14316 29424331
Prostate cancer metastatic 10.52 10.33 48 135832 4918 29433729
Haematoma 10.49 10.33 63 135817 23149 29415498
Congestive cardiomyopathy 10.49 10.33 9 135871 6621 29432026
Hair colour changes 10.48 10.33 23 135857 1588 29437059
Transurethral prostatectomy 10.46 10.33 10 135870 317 29438330
Application site erythema 10.44 10.33 27 135853 2072 29436575
Klebsiella infection 10.43 10.33 11 135869 7338 29431309
Surgery 10.42 10.33 91 135789 11688 29426959
Cyst 10.41 10.33 41 135839 3936 29434711
Blood loss anaemia 10.40 10.33 63 135817 7203 29431444
Mass 10.39 10.33 62 135818 7049 29431598
Sneezing 10.36 10.33 44 135836 4370 29434277

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1208.99 9.80 352 390349 363161 63744870
Completed suicide 867.52 9.80 156 390545 224258 63883773
Drug interaction 681.94 9.80 713 389988 361370 63746661
Drug abuse 602.88 9.80 54 390647 132320 63975711
Fatigue 524.81 9.80 6869 383832 741861 63366170
Multiple sclerosis relapse 522.34 9.80 913 389788 40222 64067809
Acute kidney injury 470.98 9.80 1290 389411 447950 63660081
Product dose omission issue 423.65 9.80 2310 388391 192437 63915594
Intentional overdose 378.13 9.80 49 390652 89895 64018136
Overdose 346.51 9.80 275 390426 159291 63948740
Back pain 299.08 9.80 2560 388141 247611 63860420
Headache 291.72 9.80 4662 386039 524805 63583226
Muscle spasms 270.45 9.80 1618 389083 139405 63968626
Infective pulmonary exacerbation of cystic fibrosis 261.91 9.80 340 390361 11456 64096575
Hepatic function abnormal 260.98 9.80 39 390662 64274 64043757
Multiple organ dysfunction syndrome 260.25 9.80 145 390556 101268 64006763
Pain in extremity 245.48 9.80 2861 387840 300224 63807807
Cardio-respiratory arrest 243.50 9.80 147 390554 98246 64009785
Thrombocytopenia 242.79 9.80 631 390070 223170 63884861
Hypotension 213.64 9.80 1391 389310 379583 63728448
Cardiac arrest 208.63 9.80 384 390317 153680 63954351
Hypoaesthesia 205.33 9.80 1495 389206 137613 63970418
Febrile neutropenia 193.76 9.80 542 390159 187115 63920916
Rhabdomyolysis 192.93 9.80 163 390538 91563 64016468
Cardiac failure 189.12 9.80 319 390382 132054 63975977
Feeling abnormal 185.36 9.80 1415 389286 132187 63975844
Depressed level of consciousness 182.23 9.80 136 390565 81300 64026731
Drug reaction with eosinophilia and systemic symptoms 173.45 9.80 56 390645 54161 64053870
Gait disturbance 172.69 9.80 1697 389004 170458 63937573
Muscle spasticity 172.63 9.80 339 390362 16330 64091701
Fall 171.39 9.80 3507 387194 413319 63694712
Hyperkalaemia 169.55 9.80 218 390483 100911 64007120
Suicide attempt 167.55 9.80 112 390589 70895 64037136
Multiple sclerosis 166.46 9.80 360 390341 18581 64089450
Neutropenia 163.76 9.80 820 389881 238804 63869227
Hyponatraemia 160.19 9.80 419 390282 147920 63960111
Memory impairment 158.39 9.80 974 389727 84708 64023323
Insomnia 155.72 9.80 1858 388843 195978 63912053
Hepatocellular injury 155.20 9.80 41 390660 45194 64062837
Arthralgia 154.77 9.80 3636 387065 438624 63669407
Septic shock 153.45 9.80 251 390450 105186 64002845
Interstitial lung disease 149.51 9.80 225 390476 97507 64010524
Influenza like illness 149.09 9.80 754 389947 60948 64047083
Electrocardiogram QT prolonged 148.53 9.80 157 390544 79291 64028740
Lactic acidosis 140.72 9.80 100 390601 61310 64046721
Peripheral swelling 139.47 9.80 1905 388796 207248 63900783
Cytomegalovirus infection 138.99 9.80 28 390673 37171 64070860
Pancytopenia 135.56 9.80 431 390270 142878 63965153
Diarrhoea 134.32 9.80 5499 385202 717205 63390826
Bone pain 133.51 9.80 607 390094 46965 64061066
Metabolic acidosis 129.56 9.80 143 390558 70815 64037216
General physical health deterioration 128.78 9.80 719 389982 203706 63904325
Paraesthesia 126.64 9.80 1309 389392 133213 63974818
Pain 125.37 9.80 4306 386395 549205 63558826
Coma 125.23 9.80 211 390490 87404 64020627
Cholestasis 124.28 9.80 58 390643 44814 64063217
Burning sensation 122.87 9.80 611 390090 49053 64058978
Influenza 122.25 9.80 1081 389620 105450 64002581
Bradycardia 120.07 9.80 344 390357 117875 63990156
Neuroleptic malignant syndrome 119.92 9.80 8 390693 24988 64083043
Respiratory arrest 116.59 9.80 90 390611 52895 64055136
Drug ineffective 114.76 9.80 4054 386647 836193 63271838
Urinary tract infection 114.36 9.80 2005 388696 229591 63878440
Night sweats 114.17 9.80 477 390224 35569 64072462
Renal failure 113.35 9.80 641 390060 181047 63926984
White blood cell count decreased 111.11 9.80 1452 389249 156385 63951646
Asthenia 110.54 9.80 3383 387318 424661 63683370
Agranulocytosis 109.66 9.80 47 390654 38182 64069849
Bone marrow failure 108.67 9.80 79 390622 47873 64060158
Mucosal inflammation 107.92 9.80 132 390569 62452 64045579
Shock 106.57 9.80 49 390652 38191 64069840
Sinusitis 104.20 9.80 1346 389355 144582 63963449
Respiratory failure 104.17 9.80 562 390139 160621 63947410
Hepatic failure 104.05 9.80 109 390592 55285 64052746
Ear pain 103.83 9.80 362 390339 24774 64083257
Full blood count decreased 103.69 9.80 337 390364 22245 64085786
Rash maculo-papular 103.32 9.80 80 390621 46946 64061085
Inappropriate schedule of product administration 102.06 9.80 929 389772 91357 64016674
Cerebral infarction 101.96 9.80 61 390640 40983 64067048
Toxic epidermal necrolysis 101.45 9.80 49 390652 37117 64070914
Vitamin D deficiency 101.34 9.80 221 390480 11471 64096560
Limb discomfort 100.90 9.80 378 390323 26797 64081234
Altered state of consciousness 100.41 9.80 52 390649 37850 64070181
Gastrooesophageal reflux disease 99.71 9.80 852 389849 82291 64025740
Poisoning 99.35 9.80 9 390692 21870 64086161
Drug resistance 96.24 9.80 46 390655 35056 64072975
Pyrexia 94.85 9.80 2618 388083 556026 63552005
Hepatotoxicity 92.97 9.80 64 390637 39898 64068133
Muscular weakness 92.79 9.80 1179 389522 126159 63981872
Intentional self-injury 91.14 9.80 31 390670 29013 64079018
Serotonin syndrome 89.95 9.80 64 390637 39218 64068813
Pemphigus 89.71 9.80 143 390558 60558 64047473
Myelosuppression 88.90 9.80 18 390683 23812 64084219
Psoriasis 88.22 9.80 739 389962 70964 64037067
Anaemia 88.02 9.80 1690 389011 376990 63731041
Infusion related reaction 87.71 9.80 609 390092 163858 63944173
Hip fracture 87.70 9.80 361 390340 26738 64081293
Full blood count abnormal 87.48 9.80 385 390316 29372 64078659
Weight decreased 87.16 9.80 2307 388394 283432 63824599
Vitamin D decreased 85.31 9.80 161 390540 7526 64100505
Agitation 84.77 9.80 264 390437 88103 64019928
Rhinorrhoea 84.69 9.80 638 390063 59331 64048700
Jaundice 83.98 9.80 102 390599 48410 64059621
Blood creatine phosphokinase increased 83.69 9.80 141 390560 58417 64049614
Tachycardia 83.69 9.80 546 390155 149033 63958998
Angioedema 82.82 9.80 155 390546 61666 64046365
Hypoglycaemia 81.75 9.80 275 390426 89617 64018414
Osteopenia 81.61 9.80 243 390458 15297 64092734
Neurotoxicity 81.34 9.80 32 390669 27372 64080659
Leukopenia 80.74 9.80 327 390374 100915 64007116
Contraindicated product administered 80.62 9.80 357 390344 107472 64000559
Spinal fracture 80.38 9.80 238 390463 14936 64093095
Toxic skin eruption 79.84 9.80 11 390690 19273 64088758
Migraine 79.79 9.80 651 390050 62026 64046005
Constipation 79.51 9.80 1884 388817 227453 63880578
Body height decreased 78.66 9.80 154 390547 7400 64100631
Melaena 78.33 9.80 127 390574 53421 64054610
Cardiogenic shock 78.04 9.80 50 390651 32377 64075654
Abdominal pain upper 77.84 9.80 1491 389210 173539 63934492
Exposure during pregnancy 76.69 9.80 229 390472 77446 64030585
Circulatory collapse 75.87 9.80 56 390645 33676 64074355
Renal impairment 75.45 9.80 493 390208 134524 63973507
Disseminated intravascular coagulation 74.99 9.80 52 390649 32296 64075735
Acute respiratory distress syndrome 74.95 9.80 75 390626 38860 64069171
Myocardial infarction 74.81 9.80 643 390058 165178 63942853
Dizziness 74.55 9.80 3251 387450 426912 63681119
Neck pain 74.53 9.80 632 390069 60901 64047130
Neutropenic sepsis 74.50 9.80 24 390677 23248 64084783
Blood calcium increased 72.38 9.80 160 390541 8382 64099649
Hypokalaemia 72.30 9.80 437 390264 121466 63986565
Ventricular fibrillation 72.25 9.80 27 390674 23833 64084198
Malignant neoplasm progression 72.10 9.80 395 390306 112476 63995555
Balance disorder 71.65 9.80 801 389900 83125 64024906
Dry skin 70.39 9.80 541 390160 50620 64057411
Nasopharyngitis 70.17 9.80 1618 389083 194455 63913576
Anaphylactic shock 69.98 9.80 49 390652 30279 64077752
Sepsis 69.27 9.80 980 389721 229361 63878670
Hepatic cytolysis 68.88 9.80 4 390697 14045 64093986
Atypical femur fracture 68.55 9.80 111 390590 4587 64103444
Pollakiuria 68.37 9.80 374 390327 31156 64076875
Stevens-Johnson syndrome 68.22 9.80 64 390637 34185 64073846
Injection site reaction 67.90 9.80 500 390201 46164 64061867
Medication error 67.17 9.80 125 390576 49841 64058190
Injection site pain 67.07 9.80 997 389704 110411 63997620
Delirium 66.87 9.80 206 390495 68988 64039043
Pneumocystis jirovecii pneumonia 65.97 9.80 43 390658 27591 64080440
Hot flush 65.91 9.80 493 390208 45742 64062289
Hand deformity 65.68 9.80 180 390521 62591 64045440
Product use in unapproved indication 64.48 9.80 721 389980 175897 63932134
Hospitalisation 64.29 9.80 718 389983 74489 64033542
Off label use 63.34 9.80 4547 386154 628259 63479772
Acute hepatic failure 63.20 9.80 40 390661 26072 64081959
Torsade de pointes 62.96 9.80 14 390687 17349 64090682
Extrapyramidal disorder 62.88 9.80 20 390681 19532 64088499
Carpal tunnel syndrome 62.83 9.80 225 390476 15603 64092428
Plasma cell myeloma 62.71 9.80 486 390215 45589 64062442
Bone density decreased 62.44 9.80 166 390535 9786 64098245
Cough 61.86 9.80 2325 388376 299823 63808208
Synovitis 60.99 9.80 351 390350 98739 64009292
Nasal congestion 60.17 9.80 589 390112 59069 64048962
Dysgeusia 60.06 9.80 489 390212 46558 64061473
Sedation 60.02 9.80 99 390602 41363 64066668
Anuria 59.92 9.80 20 390681 18944 64089087
Ascites 59.62 9.80 185 390516 61816 64046215
Mycotic allergy 59.58 9.80 49 390652 949 64107082
Blood bilirubin increased 59.50 9.80 166 390535 57387 64050644
Bronchitis 59.28 9.80 957 389744 107786 64000245
Injection site erythema 59.19 9.80 673 390028 70127 64037904
Anaphylactic reaction 59.11 9.80 215 390486 68449 64039582
Contusion 58.82 9.80 994 389707 112971 63995060
International normalised ratio increased 58.63 9.80 263 390438 78904 64029127
Confusional state 58.31 9.80 1173 389528 259971 63848060
Mydriasis 58.31 9.80 11 390690 15301 64092730
Pruritus 58.11 9.80 2379 388322 310021 63798010
Gait spastic 57.92 9.80 46 390655 846 64107185
Osteoarthritis 57.52 9.80 612 390089 62724 64045307
Blood test abnormal 57.49 9.80 191 390510 12752 64095279
Myoclonus 57.40 9.80 41 390660 25077 64082954
Drug-induced liver injury 57.38 9.80 127 390574 47516 64060515
Hypervitaminosis D 57.21 9.80 22 390679 80 64107951
Injection site pruritus 57.16 9.80 409 390292 37417 64070614
Gamma-glutamyltransferase increased 57.05 9.80 131 390570 48379 64059652
Haematemesis 56.84 9.80 125 390576 46874 64061157
Central nervous system lesion 56.37 9.80 179 390522 11670 64096361
Dry mouth 56.37 9.80 587 390114 59831 64048200
Labelled drug-drug interaction medication error 55.91 9.80 32 390669 22030 64086001
Blood lactate dehydrogenase increased 55.73 9.80 71 390630 33007 64075024
Sleep disorder due to a general medical condition 55.41 9.80 141 390560 8093 64099938
Oropharyngeal pain 55.34 9.80 800 389901 88067 64019964
Aggression 55.06 9.80 124 390577 46108 64061923
Nephrolithiasis 54.67 9.80 452 390249 43231 64064800
Urine leukocyte esterase positive 54.63 9.80 84 390617 3319 64104712
Bone density abnormal 54.61 9.80 75 390626 2670 64105361
Accidental overdose 54.52 9.80 74 390627 33483 64074548
Liver function test abnormal 54.50 9.80 181 390520 59220 64048811
Transaminases increased 54.43 9.80 118 390583 44476 64063555
Systemic lupus erythematosus 54.42 9.80 263 390438 77349 64030682
Nausea 54.01 9.80 5490 385211 780310 63327721
Respiratory depression 53.93 9.80 38 390663 23405 64084626
Dyspepsia 53.64 9.80 732 389969 79580 64028451
Drug eruption 53.51 9.80 85 390616 36051 64071980
Hyperbilirubinaemia 53.39 9.80 31 390670 21174 64086857
Ventricular tachycardia 53.24 9.80 78 390623 34187 64073844
Eosinophilia 53.20 9.80 93 390608 37983 64070048
Alanine aminotransferase increased 52.96 9.80 562 390139 138469 63969562
Coronary artery disease 52.83 9.80 188 390513 60245 64047786
Cystic fibrosis 52.66 9.80 83 390618 3351 64104680
Respiratory distress 52.58 9.80 153 390548 52178 64055853
Encephalopathy 52.08 9.80 182 390519 58637 64049394
Pericarditis 51.69 9.80 199 390502 62317 64045714
Cytokine release syndrome 51.67 9.80 31 390670 20798 64087233
Hyperthermia 51.64 9.80 15 390686 15535 64092496
Cerebral haemorrhage 51.60 9.80 149 390552 50941 64057090
Bronchopulmonary aspergillosis 50.82 9.80 26 390675 19059 64088972
Myalgia 50.71 9.80 1289 389412 157328 63950703
Sinus disorder 50.64 9.80 220 390481 16688 64091343
Posterior reversible encephalopathy syndrome 50.44 9.80 39 390662 22907 64085124
Abdominal distension 50.17 9.80 839 389862 95155 64012876
Asthma 50.03 9.80 833 389868 94392 64013639
Haematotoxicity 49.68 9.80 9 390692 12887 64095144
Breast cancer 49.28 9.80 324 390377 28824 64079207
Brain oedema 49.19 9.80 37 390664 22038 64085993
Bowel movement irregularity 49.05 9.80 97 390604 4696 64103335
Bone giant cell tumour 49.01 9.80 17 390684 42 64107989
Hypertensive crisis 48.39 9.80 25 390676 18223 64089808
Flushing 48.17 9.80 706 389995 77942 64030089
Injection site bruising 48.03 9.80 381 390320 35992 64072039
Chills 47.93 9.80 1129 389572 136135 63971896
Haemodialysis 47.40 9.80 22 390679 17055 64090976
Drug level increased 47.34 9.80 84 390617 34112 64073919
Aspartate aminotransferase increased 47.34 9.80 480 390221 119308 63988723
Blood parathyroid hormone increased 47.03 9.80 75 390626 3059 64104972
Micturition urgency 47.02 9.80 154 390547 10205 64097826
Ejection fraction decreased 46.94 9.80 63 390638 28644 64079387
Sensitisation 46.64 9.80 55 390646 1676 64106355
Thoracic vertebral fracture 46.42 9.80 92 390609 4461 64103570
Urine abnormality 46.39 9.80 123 390578 7239 64100792
Red blood cell count decreased 46.03 9.80 472 390229 47914 64060117
Acute generalised exanthematous pustulosis 45.89 9.80 14 390687 14044 64093987
Venoocclusive liver disease 45.79 9.80 4 390697 10011 64098020
Wrist fracture 45.69 9.80 149 390552 9852 64098179
Miosis 45.55 9.80 12 390689 13254 64094777
Therapy cessation 45.50 9.80 345 390356 32144 64075887
Thrombotic microangiopathy 45.39 9.80 22 390679 16633 64091398
Febrile bone marrow aplasia 45.25 9.80 7 390694 11248 64096783
Cardiotoxicity 44.63 9.80 5 390696 10269 64097762
Productive cough 44.39 9.80 656 390045 72547 64035484
Pulmonary mass 44.34 9.80 273 390428 23743 64084288
Erythema multiforme 43.93 9.80 20 390681 15681 64092350
Status epilepticus 43.71 9.80 40 390661 21623 64086408
Gastrointestinal haemorrhage 43.71 9.80 552 390149 131760 63976271
Respiratory tract congestion 42.93 9.80 203 390498 15962 64092069
Vitamin D increased 42.93 9.80 30 390671 450 64107581
Colitis ulcerative 42.66 9.80 262 390439 22766 64085265
Ankle fracture 42.23 9.80 189 390512 14521 64093510
Gait inability 42.09 9.80 417 390284 41951 64066080
Vision blurred 42.05 9.80 775 389926 89541 64018490
Hypercalcaemia 41.99 9.80 330 390371 31086 64076945
Inappropriate antidiuretic hormone secretion 41.69 9.80 44 390657 22245 64085786
Shock haemorrhagic 41.64 9.80 25 390676 16766 64091265
Angina pectoris 41.60 9.80 137 390564 44944 64063087
Polycystic ovaries 41.56 9.80 58 390643 2097 64105934
Flatulence 41.44 9.80 363 390338 35303 64072728
Polyneuropathy 41.02 9.80 36 390665 19858 64088173
Death 40.61 9.80 2452 388249 480253 63627778
Post transplant lymphoproliferative disorder 40.58 9.80 5 390696 9539 64098492
Mobility decreased 40.46 9.80 738 389963 85102 64022929
Oral pain 40.23 9.80 295 390406 27198 64080833
Cyanosis 40.04 9.80 45 390656 22110 64085921
Pathogen resistance 40.03 9.80 13 390688 12530 64095501
Acute myocardial infarction 39.73 9.80 253 390448 69465 64038566
Stress fracture 39.62 9.80 98 390603 5526 64102505
Injection site mass 39.58 9.80 208 390493 17062 64090969
Musculoskeletal discomfort 39.36 9.80 199 390502 16078 64091953
Pleural effusion 39.24 9.80 535 390166 126024 63982007
Psoriatic arthropathy 39.19 9.80 418 390283 42863 64065168
C-reactive protein increased 38.88 9.80 377 390324 94532 64013499
Akathisia 38.41 9.80 11 390690 11499 64096532
Left ventricular dysfunction 38.32 9.80 28 390673 16926 64091105
Cataract 38.32 9.80 477 390224 50785 64057246
Relapsing-remitting multiple sclerosis 38.11 9.80 40 390661 1068 64106963
Acute graft versus host disease 38.04 9.80 5 390696 9079 64098952
Rheumatoid arthritis 37.95 9.80 1282 389419 163012 63945019
Loss of consciousness 37.55 9.80 652 390049 147713 63960318
Hepatitis acute 37.55 9.80 17 390684 13372 64094659
Haemophagocytic lymphohistiocytosis 37.37 9.80 31 390670 17578 64090453
Substance abuse 36.86 9.80 6 390695 9286 64098745
Hernia 36.81 9.80 171 390530 13347 64094684
Dystonia 36.70 9.80 36 390665 18829 64089202
Taste disorder 36.51 9.80 133 390568 9300 64098731
Epstein-Barr virus infection 36.38 9.80 15 390686 12473 64095558
Cystitis 36.27 9.80 407 390294 42268 64065763
Myocardial ischaemia 36.05 9.80 53 390648 23198 64084833
Blood pressure abnormal 35.98 9.80 178 390523 14257 64093774
Rib fracture 35.78 9.80 259 390442 23779 64084252
Tumour lysis syndrome 35.67 9.80 39 390662 19401 64088630
Gastrointestinal pain 35.65 9.80 114 390587 7460 64100571
Needle fatigue 35.38 9.80 29 390672 559 64107472
Acute myeloid leukaemia 34.92 9.80 71 390630 27392 64080639
Ejection fraction 34.88 9.80 41 390660 1245 64106786
Hyperglycaemia 34.86 9.80 221 390480 60747 64047284
Hepatitis 34.61 9.80 150 390551 45432 64062599
Electrocardiogram QRS complex prolonged 34.44 9.80 7 390694 9237 64098794
Glossodynia 34.24 9.80 240 390461 64456 64043575
Loss of personal independence in daily activities 34.17 9.80 623 390078 71831 64036200
Intramedullary rod insertion 34.13 9.80 18 390683 156 64107875
Cyst 34.13 9.80 154 390547 11873 64096158
Prescribed underdose 34.03 9.80 206 390495 17809 64090222
Injection site urticaria 33.88 9.80 146 390555 11035 64096996
JC polyomavirus test positive 33.84 9.80 40 390661 1222 64106809
Stress 33.83 9.80 535 390166 59999 64048032
Sneezing 33.80 9.80 182 390519 15069 64092962
Disorientation 33.68 9.80 199 390502 55629 64052402
Graft versus host disease 33.65 9.80 21 390680 13792 64094239
Musculoskeletal stiffness 33.61 9.80 981 389720 122225 63985806
Muscle tightness 33.57 9.80 145 390556 10970 64097061
Dry eye 33.53 9.80 295 390406 28724 64079307
Suspected suicide 33.42 9.80 6 390695 8648 64099383
Mucormycosis 33.38 9.80 3 390698 7338 64100693
Psychotic disorder 33.36 9.80 103 390598 34475 64073556
Aspergillus infection 33.34 9.80 30 390671 16349 64091682
Face oedema 33.23 9.80 62 390639 24699 64083332
Haemodynamic instability 33.22 9.80 25 390676 14887 64093144
Pathological fracture 33.21 9.80 125 390576 8880 64099151
Depression 33.15 9.80 1392 389309 181899 63926132
Hypervitaminosis 32.96 9.80 11 390690 23 64108008
Foot fracture 32.64 9.80 205 390496 17952 64090079
Invasive ductal breast carcinoma 32.55 9.80 85 390616 4957 64103074
Hypertransaminasaemia 32.54 9.80 3 390698 7188 64100843
Epilepsy 32.27 9.80 100 390601 33431 64074600
Alopecia 32.19 9.80 1268 389433 164422 63943609
Tooth fracture 31.92 9.80 132 390569 9795 64098236
Frequent bowel movements 31.87 9.80 205 390496 18100 64089931
Nasal turbinate hypertrophy 31.78 9.80 27 390674 548 64107483
Haematoma 31.68 9.80 158 390543 46092 64061939
Coagulopathy 31.57 9.80 94 390607 31826 64076205
Bone loss 31.56 9.80 51 390650 2104 64105927
Bone lesion 31.54 9.80 85 390616 5052 64102979
Jaundice cholestatic 31.41 9.80 7 390694 8663 64099368
Upper limb fracture 31.33 9.80 175 390526 14691 64093340
Bronchial neoplasm 31.27 9.80 24 390677 419 64107612
Nephropathy toxic 31.19 9.80 36 390665 17478 64090553
Secondary progressive multiple sclerosis 31.04 9.80 38 390663 1205 64106826
Hypoacusis 30.95 9.80 265 390436 25602 64082429
Coma scale abnormal 30.88 9.80 5 390696 7769 64100262
Sedation complication 30.88 9.80 12 390689 10342 64097689
Dermatitis exfoliative 30.87 9.80 12 390689 10340 64097691
Lumbar vertebral fracture 30.77 9.80 88 390613 5414 64102617
Transplant rejection 30.74 9.80 36 390665 17365 64090666
Sinus congestion 30.74 9.80 179 390522 15260 64092771
Ischaemic stroke 30.56 9.80 83 390618 28952 64079079
Lymphocyte count decreased 30.54 9.80 379 390322 40320 64067711
Hepatic necrosis 30.38 9.80 7 390694 8466 64099565
Pain in jaw 30.36 9.80 379 390322 40376 64067655
Clostridium difficile infection 30.33 9.80 344 390357 35819 64072212
Calciphylaxis 30.31 9.80 64 390637 3248 64104783
Syncope 30.27 9.80 725 389976 156910 63951121
Lower limb fracture 30.26 9.80 162 390539 13383 64094648
Hypersomnia 30.25 9.80 214 390487 19503 64088528
Visual impairment 30.19 9.80 623 390078 73454 64034577
Acute coronary syndrome 29.96 9.80 44 390657 19266 64088765
Seizure 29.77 9.80 776 389925 166116 63941915
Tooth disorder 29.76 9.80 235 390466 22167 64085864
Injection site swelling 29.71 9.80 382 390319 40971 64067060
Glaucoma 29.65 9.80 185 390516 16163 64091868
Palpitations 29.61 9.80 836 389865 103652 64004379
Sleep apnoea syndrome 29.33 9.80 293 390408 29539 64078492
Oliguria 29.31 9.80 27 390674 14549 64093482
Feeling hot 29.18 9.80 413 390288 45250 64062781
Endometriosis 29.17 9.80 57 390644 2735 64105296
Sudden death 29.07 9.80 48 390653 20048 64087983
Hallucination, auditory 28.91 9.80 36 390665 16903 64091128
Thrombosis 28.76 9.80 594 390107 70048 64037983
Folliculitis 28.73 9.80 90 390611 29987 64078044
Upper respiratory tract infection 28.32 9.80 608 390093 72177 64035854
Acute graft versus host disease in skin 28.17 9.80 4 390697 6851 64101180
Dry throat 27.71 9.80 92 390609 6140 64101891
Cystitis haemorrhagic 27.69 9.80 7 390694 7949 64100082
Thyroid disorder 27.61 9.80 142 390559 11550 64096481
Hepatitis fulminant 27.39 9.80 3 390698 6271 64101760
Pancreatitis acute 27.34 9.80 150 390551 42705 64065326
Tooth extraction 27.29 9.80 123 390578 9478 64098553
Hypothermia 27.28 9.80 49 390652 19807 64088224
Injection site rash 27.23 9.80 176 390525 15566 64092465
Purpura 27.05 9.80 39 390662 17207 64090824
Body temperature increased 26.89 9.80 340 390361 36326 64071705
Pleural thickening 26.72 9.80 54 390647 2656 64105375
Vitamin B12 decreased 26.65 9.80 54 390647 2661 64105370
Aplastic anaemia 26.58 9.80 27 390674 13893 64094138
Femur fracture 26.53 9.80 320 390381 33815 64074216
Pre-existing condition improved 26.48 9.80 76 390625 4686 64103345
Bronchial wall thickening 26.40 9.80 44 390657 1863 64106168
Acne 26.34 9.80 234 390467 22847 64085184
Foreign body in reproductive tract 26.20 9.80 22 390679 439 64107592
Diverticulitis 26.19 9.80 353 390348 38265 64069766
Osteomalacia 26.17 9.80 37 390664 1354 64106677
Haematuria 26.13 9.80 237 390464 60234 64047797
Blepharospasm 26.13 9.80 61 390640 3314 64104717
Wheezing 26.07 9.80 656 390045 79923 64028108
Blood calcium abnormal 26.07 9.80 35 390666 1219 64106812
Muscle injury 26.04 9.80 78 390623 26359 64081672
Sinus bradycardia 25.98 9.80 63 390638 22830 64085201
Muscle rigidity 25.96 9.80 41 390660 17432 64090599
Endometrial ablation 25.93 9.80 28 390673 773 64107258
Fracture displacement 25.93 9.80 34 390667 1157 64106874
Orthostatic hypotension 25.92 9.80 171 390530 46567 64061464
Skin discolouration 25.89 9.80 327 390374 34928 64073103
Arrhythmia 25.81 9.80 201 390500 52743 64055288
Therapy partial responder 25.78 9.80 15 390686 10233 64097798
Weight increased 25.69 9.80 1558 389143 211790 63896241
Urine analysis abnormal 25.62 9.80 85 390616 5671 64102360
Dental implantation 25.52 9.80 21 390680 407 64107624
Head discomfort 25.40 9.80 140 390561 11694 64096337
Intervertebral disc degeneration 25.40 9.80 151 390550 12969 64095062
Seasonal allergy 25.36 9.80 139 390562 11587 64096444
Abdominal discomfort 25.36 9.80 1349 389352 180973 63927058
Pulmonary oedema 25.32 9.80 330 390371 78344 64029687
Atrioventricular block complete 25.28 9.80 30 390671 14388 64093643
Angina unstable 25.23 9.80 34 390667 15433 64092598
Blood magnesium decreased 25 9.80 157 390544 13748 64094283
Urine odour abnormal 24.81 9.80 78 390623 5058 64102973
Fibromyalgia 24.81 9.80 328 390373 35403 64072628
Dysstasia 24.78 9.80 232 390469 22983 64085048
Neuralgia 24.70 9.80 255 390446 25929 64082102
Hypertonic bladder 24.55 9.80 60 390641 3358 64104673
Hypocalcaemia 24.46 9.80 372 390329 41381 64066650
Drug dependence 24.46 9.80 111 390590 33201 64074830
Pulmonary haemorrhage 24.38 9.80 26 390675 13083 64094948
Spinal operation 24.18 9.80 87 390614 6046 64101985
Therapeutic product effect incomplete 24.01 9.80 808 389893 102674 64005357
Ankylosing spondylitis 23.79 9.80 106 390595 8128 64099903
Generalised tonic-clonic seizure 23.55 9.80 143 390558 39714 64068317
Dermatitis bullous 23.45 9.80 23 390678 12031 64096000
Upper gastrointestinal haemorrhage 23.17 9.80 122 390579 35098 64072933
Peroneal nerve palsy 23.17 9.80 78 390623 5243 64102788
Enterococcal infection 23.11 9.80 30 390671 13836 64094195
Ileus paralytic 23.11 9.80 11 390690 8404 64099627
Hepatic encephalopathy 23.10 9.80 59 390642 21007 64087024
Treatment failure 23.05 9.80 535 390166 116281 63991750
Accidental exposure to product 23.05 9.80 82 390619 26282 64081749
Parkinsonism 23.04 9.80 32 390669 14341 64093690
Blood iron decreased 23.03 9.80 139 390562 12003 64096028
Mixed liver injury 22.99 9.80 3 390698 5478 64102553
Increased tendency to bruise 22.98 9.80 114 390587 9141 64098890
Therapeutic response unexpected 22.95 9.80 179 390522 16822 64091209
Nervousness 22.94 9.80 277 390424 29279 64078752
Hair texture abnormal 22.94 9.80 54 390647 2950 64105081
Blood pressure diastolic abnormal 22.88 9.80 23 390678 11894 64096137
Drug hypersensitivity 22.88 9.80 1192 389509 236623 63871408
Chronic graft versus host disease 22.88 9.80 5 390696 6271 64101760
Recalled product 22.80 9.80 28 390673 891 64107140
Blood potassium decreased 22.55 9.80 357 390344 40042 64067989
Maternal exposure during pregnancy 22.48 9.80 427 390274 95457 64012574
Toxic encephalopathy 22.46 9.80 16 390685 9799 64098232
Blood pressure increased 22.28 9.80 1268 389433 171284 63936747
Pulmonary tuberculosis 22.27 9.80 8 390693 7236 64100795
Gastrointestinal toxicity 22.12 9.80 3 390698 5319 64102712
Pulmonary alveolar haemorrhage 22.11 9.80 16 390685 9722 64098309
Ketoacidosis 22.10 9.80 7 390694 6856 64101175
Tubulointerstitial nephritis 22.09 9.80 104 390597 30805 64077226
Crying 22.07 9.80 202 390499 19888 64088143
Hepatomegaly 22.01 9.80 43 390658 16839 64091192
Blood urine present 22.00 9.80 188 390513 18152 64089879
Lacrimation increased 21.98 9.80 188 390513 18158 64089873
Lymphocyte percentage decreased 21.90 9.80 70 390631 4579 64103452
Haemolytic anaemia 21.71 9.80 40 390661 16013 64092018
Ear infection 21.64 9.80 227 390474 23177 64084854
Dysphonia 21.58 9.80 398 390303 45984 64062047
Anti-cyclic citrullinated peptide antibody positive 21.52 9.80 194 390507 49368 64058663
Hallucination, visual 21.49 9.80 91 390610 27743 64080288
Bladder operation 21.48 9.80 25 390676 751 64107280
Intraductal proliferative breast lesion 21.37 9.80 43 390658 2108 64105923
Milk-alkali syndrome 21.37 9.80 31 390670 1162 64106869
Compression fracture 21.34 9.80 80 390621 5672 64102359
Illness 21.34 9.80 215 390486 21723 64086308
Abnormal faeces 21.33 9.80 81 390620 5778 64102253
Surgery 21.28 9.80 263 390438 27950 64080081
Bradypnoea 21.22 9.80 3 390698 5156 64102875
Viral infection 21.18 9.80 322 390379 35818 64072213
Encephalitis 21.16 9.80 27 390674 12544 64095487
Monocyte percentage increased 21.10 9.80 41 390660 1959 64106072
Eye swelling 21.02 9.80 217 390484 22064 64085967
Poor venous access 20.97 9.80 138 390563 12279 64095752
Schizophrenia 20.94 9.80 22 390679 11146 64096885
Leukoencephalopathy 20.90 9.80 8 390693 6959 64101072
Appetite disorder 20.85 9.80 86 390615 6375 64101656
Skin haemorrhage 20.79 9.80 105 390596 8480 64099551
Cholecystectomy 20.70 9.80 100 390601 7932 64100099
Concussion 20.58 9.80 99 390602 7839 64100192
Anti-transglutaminase antibody increased 20.55 9.80 6 390695 6 64108025
Torus fracture 20.52 9.80 10 390691 72 64107959
Oral discomfort 20.49 9.80 103 390598 8303 64099728
Drug intolerance 20.48 9.80 930 389771 187062 63920969
Pallor 20.45 9.80 144 390557 38637 64069394
Rhinitis allergic 20.41 9.80 100 390601 7978 64100053
Upper-airway cough syndrome 20.35 9.80 106 390595 8664 64099367
Intentional underdose 20.28 9.80 41 390660 2017 64106014
Pulmonary function test decreased 20.06 9.80 85 390616 6376 64101655
Drug screen positive 20.02 9.80 5 390696 5724 64102307
Gastroenteritis viral 19.99 9.80 195 390506 19534 64088497
BK virus infection 19.88 9.80 10 390691 7402 64100629
Cytomegalovirus chorioretinitis 19.87 9.80 3 390698 4909 64103122
Congestive cardiomyopathy 19.82 9.80 20 390681 10324 64097707
Cervix neoplasm 19.67 9.80 13 390688 177 64107854
Brain death 19.60 9.80 3 390698 4858 64103173
Urine ketone body present 19.58 9.80 54 390647 3253 64104778
Cytomegalovirus viraemia 19.56 9.80 22 390679 10806 64097225
Ageusia 19.52 9.80 147 390554 13666 64094365
Urticaria 19.49 9.80 1085 389616 146232 63961799
Helicobacter infection 19.48 9.80 144 390557 38218 64069813
Blood pressure fluctuation 19.44 9.80 431 390270 51440 64056591
Blood cholesterol increased 19.40 9.80 418 390283 49648 64058383
Wound 19.37 9.80 336 390365 76141 64031890
Frustration tolerance decreased 19.35 9.80 81 390620 6044 64101987
Chest discomfort 19.25 9.80 874 389827 115232 63992799
Bronchospasm 19.25 9.80 67 390634 21615 64086416
COVID-19 19.24 9.80 524 390177 64616 64043415
Faecal calprotectin increased 19.19 9.80 57 390644 3583 64104448
Gingival pain 19.18 9.80 83 390618 6284 64101747
Heparin-induced thrombocytopenia 19.17 9.80 14 390687 8465 64099566
Immunosuppressant drug level increased 19.16 9.80 10 390691 7249 64100782
Adenovirus infection 19.15 9.80 10 390691 7245 64100786
Hepatic enzyme abnormal 19.06 9.80 78 390623 5761 64102270
Poor quality sleep 19.05 9.80 187 390514 18764 64089267
Respiratory disorder 18.99 9.80 316 390385 35795 64072236
Tuberculosis 18.99 9.80 31 390670 13007 64095024
Onychoclasis 18.85 9.80 66 390635 4526 64103505
Pemphigoid 18.80 9.80 31 390670 12955 64095076
Anxiety 18.77 9.80 1448 389253 201201 63906830
Nephrocalcinosis 18.76 9.80 31 390670 1303 64106728
Lymphoproliferative disorder 18.73 9.80 4 390697 5099 64102932
Facial pain 18.72 9.80 96 390605 7799 64100232
Mean cell haemoglobin increased 18.68 9.80 52 390649 3150 64104881
Hepatitis cholestatic 18.56 9.80 28 390673 12127 64095904
Red cell distribution width increased 18.54 9.80 133 390568 12176 64095855
Toothache 18.40 9.80 174 390527 17285 64090746
Blood urea increased 18.24 9.80 175 390526 43978 64064053
Activated partial thromboplastin time prolonged 18.23 9.80 31 390670 12800 64095231
Intentional product misuse 18.19 9.80 318 390383 71977 64036054
Acute pulmonary oedema 18.15 9.80 31 390670 12778 64095253
Paraesthesia oral 18.14 9.80 139 390562 12992 64095039
Malaise 18.10 9.80 2700 388001 393547 63714484
Back disorder 18.09 9.80 113 390588 9877 64098154
Abortion induced 18.09 9.80 8 390693 6380 64101651
Drug use disorder 18.08 9.80 7 390694 6047 64101984
Central obesity 18.08 9.80 32 390669 1423 64106608
Coronary artery stenosis 18.07 9.80 25 390676 11223 64096808
Transplant dysfunction 18.07 9.80 9 390692 6699 64101332
Colitis microscopic 18.07 9.80 91 390610 7341 64100690
Bronchopulmonary aspergillosis allergic 18.03 9.80 34 390667 1588 64106443
Heart rate irregular 17.94 9.80 249 390452 27164 64080867
Sputum purulent 17.93 9.80 29 390672 1197 64106834
Pulseless electrical activity 17.90 9.80 31 390670 12708 64095323
Increased appetite 17.90 9.80 114 390587 10032 64097999
Acidosis 17.89 9.80 52 390649 17743 64090288
Tonsillar ulcer 17.87 9.80 17 390684 402 64107629
Heart rate abnormal 17.83 9.80 69 390632 4966 64103065
Respiratory acidosis 17.83 9.80 20 390681 9835 64098196
Ileus 17.79 9.80 75 390626 22891 64085140
Subarachnoid haemorrhage 17.73 9.80 55 390646 18383 64089648
Colitis ischaemic 17.64 9.80 34 390667 13380 64094651
Hypoxia 17.59 9.80 403 390298 87746 64020285
Isosthenuria 17.58 9.80 10 390691 102 64107929
Joint lock 17.54 9.80 47 390654 2784 64105247
Spinal compression fracture 17.48 9.80 151 390550 14624 64093407
Hypercalciuria 17.40 9.80 17 390684 416 64107615
Hyperlactacidaemia 17.37 9.80 4 390697 4840 64103191
Arthritis 17.35 9.80 646 390055 83168 64024863
Carbohydrate antigen 125 increased 17.35 9.80 37 390664 1891 64106140
Myelodysplastic syndrome 17.33 9.80 97 390604 27482 64080549
Hyperparathyroidism 17.32 9.80 47 390654 2805 64105226
Presbyacusis 17.23 9.80 44 390657 2531 64105500
Sinus tachycardia 17.23 9.80 119 390582 32069 64075962
Unresponsive to stimuli 17.10 9.80 209 390492 50184 64057847
Renal injury 17.08 9.80 43 390658 15386 64092645
Liver disorder 17.08 9.80 224 390477 53127 64054904
Psychomotor retardation 17.01 9.80 5 390696 5138 64102893
Vertebral wedging 16.98 9.80 6 390695 16 64108015
Nocardiosis 16.97 9.80 4 390697 4763 64103268
Tachypnoea 16.95 9.80 93 390608 26478 64081553
Immune system disorder 16.93 9.80 104 390597 9037 64098994
Osteosclerosis 16.89 9.80 53 390648 3433 64104598
Gallbladder operation 16.84 9.80 34 390667 1671 64106360
Hypoalbuminaemia 16.80 9.80 53 390648 17621 64090410
Tibia fracture 16.78 9.80 65 390636 4680 64103351
Pneumonia cytomegaloviral 16.77 9.80 3 390698 4336 64103695
Product prescribing error 16.68 9.80 135 390566 35134 64072897
Hyperpyrexia 16.67 9.80 5 390696 5072 64102959
Essential hypertension 16.65 9.80 69 390632 5125 64102906
Blood magnesium increased 16.47 9.80 50 390651 3181 64104850
Hyperexplexia 16.46 9.80 7 390694 35 64107996
Ileal stenosis 16.43 9.80 38 390663 2052 64105979
Neuropathy peripheral 16.41 9.80 870 389831 116655 63991376
Pelvic fracture 16.41 9.80 115 390586 10448 64097583
Nonspecific reaction 16.39 9.80 37 390664 1966 64106065
Exostosis 16.32 9.80 122 390579 11316 64096715
Lip dry 16.29 9.80 66 390635 4852 64103179
Enterocolitis 16.21 9.80 30 390671 11988 64096043
Sciatica 16.20 9.80 191 390510 20073 64087958
Osteoporosis 16.20 9.80 351 390350 41729 64066302
Hypomania 16.14 9.80 7 390694 5647 64102384
Skin toxicity 16.13 9.80 10 390691 6592 64101439
Movement disorder 16.13 9.80 204 390497 21796 64086235
Myopathy 16.12 9.80 54 390647 17626 64090405
Creatinine renal clearance decreased 16.11 9.80 40 390661 14381 64093650
Bradyphrenia 16.04 9.80 20 390681 9386 64098645
Sinus headache 16.02 9.80 59 390642 4148 64103883
Neutropenic colitis 16.00 9.80 4 390697 4577 64103454
Groin pain 15.96 9.80 121 390580 11272 64096759
Hyperammonaemia 15.93 9.80 22 390679 9882 64098149
Gastrointestinal inflammation 15.87 9.80 77 390624 6118 64101913
Underdose 15.86 9.80 232 390469 25597 64082434
Nicotine dependence 15.83 9.80 22 390679 792 64107239
Blood creatinine abnormal 15.81 9.80 58 390643 4069 64103962
Erysipelas 15.81 9.80 19 390682 9062 64098969
Persecutory delusion 15.81 9.80 3 390698 4155 64103876
Depressed mood 15.76 9.80 342 390359 40670 64067361
Ventricular hypertrophy 15.74 9.80 10 390691 6506 64101525
Neutralising antibodies positive 15.71 9.80 13 390688 254 64107777
Duodenal ulcer perforation 15.71 9.80 134 390567 34491 64073540
Heart rate decreased 15.71 9.80 441 390260 54626 64053405
Peripheral sensory neuropathy 15.70 9.80 28 390673 11350 64096681
Oxygen saturation decreased 15.67 9.80 512 390189 106664 64001367
Collagen-vascular disease 15.61 9.80 8 390693 65 64107966
Device use error 15.54 9.80 10 390691 6461 64101570
Cardiovascular disorder 15.54 9.80 47 390654 15834 64092197
Cervical vertebral fracture 15.50 9.80 48 390653 3087 64104944
Electrocardiogram PR shortened 15.50 9.80 13 390688 259 64107772
Spinal pain 15.47 9.80 130 390571 12491 64095540
Premature labour 15.46 9.80 14 390687 7606 64100425
Renal tubular necrosis 15.45 9.80 75 390626 22035 64085996
Intestinal ischaemia 15.42 9.80 29 390672 11520 64096511
Unintentional medical device removal 15.38 9.80 11 390690 6723 64101308
Gastric haemorrhage 15.37 9.80 37 390664 13444 64094587
Paradoxical drug reaction 15.33 9.80 9 390692 6111 64101920
Anhedonia 15.33 9.80 38 390663 13668 64094363
Rhonchi 15.29 9.80 51 390650 3412 64104619
Hyperammonaemic encephalopathy 15.27 9.80 3 390698 4055 64103976
Immediate post-injection reaction 15.25 9.80 14 390687 316 64107715
Prostatic specific antigen increased 15.19 9.80 98 390603 8662 64099369
Product monitoring error 15.18 9.80 7 390694 5447 64102584
Clonus 15.09 9.80 9 390692 6058 64101973
Hypernatraemia 15.08 9.80 32 390669 12157 64095874
Rheumatoid nodule 15.01 9.80 34 390667 12617 64095414
Refusal of treatment by patient 15.00 9.80 17 390684 8322 64099709
Small intestinal obstruction 14.98 9.80 213 390488 23360 64084671
Hospice care 14.92 9.80 88 390613 7537 64100494
Ventricular hypokinesia 14.91 9.80 15 390686 7754 64100277
Tachyarrhythmia 14.90 9.80 9 390692 6017 64102014
Blood lactic acid increased 14.90 9.80 25 390676 10376 64097655
Cardiac failure acute 14.85 9.80 50 390651 16294 64091737
Retroperitoneal haematoma 14.83 9.80 5 390696 4706 64103325
Eosinophil percentage increased 14.79 9.80 29 390672 1395 64106636
Nocturia 14.76 9.80 117 390584 11048 64096983
Second primary malignancy 14.76 9.80 33 390668 12304 64095727
Arthropod bite 14.75 9.80 80 390621 6641 64101390
Atypical fracture 14.70 9.80 19 390682 637 64107394
Diabetic ketoacidosis 14.69 9.80 113 390588 29732 64078299
Laryngeal pain 14.68 9.80 8 390693 5660 64102371
Hypophosphataemia 14.67 9.80 145 390556 14575 64093456
Gingival recession 14.67 9.80 25 390676 1078 64106953
Peritonitis 14.67 9.80 90 390611 24933 64083098
Duodenal ulcer 14.65 9.80 42 390659 14393 64093638
Sensitive skin 14.62 9.80 24 390677 1003 64107028
Metabolic disorder 14.62 9.80 15 390686 7682 64100349
Procedural pain 14.61 9.80 151 390550 15357 64092674
Lower respiratory tract infection viral 14.53 9.80 23 390678 932 64107099
Rotator cuff syndrome 14.47 9.80 124 390577 11983 64096048
Mean cell haemoglobin concentration abnormal 14.44 9.80 9 390692 110 64107921
Band sensation 14.41 9.80 19 390682 650 64107381
Hypovolaemic shock 14.41 9.80 25 390676 10241 64097790
Dermatitis exfoliative generalised 14.40 9.80 9 390692 5907 64102124
Intentional dose omission 14.30 9.80 70 390631 5582 64102449
Nephrogenic systemic fibrosis 14.29 9.80 9 390692 5883 64102148
Cutaneous vasculitis 14.23 9.80 11 390690 6462 64101569
Blood culture positive 14.20 9.80 16 390685 7852 64100179
Blood cholesterol abnormal 14.15 9.80 42 390659 2639 64105392
Musculoskeletal pain 14.14 9.80 615 390086 80679 64027352
Large intestine perforation 14.05 9.80 35 390666 12569 64095462
Skin burning sensation 14.05 9.80 111 390590 10472 64097559
Road traffic accident 14.01 9.80 263 390438 30482 64077549
C-reactive protein decreased 14.00 9.80 36 390665 2080 64105951
Oesophageal discomfort 13.98 9.80 12 390689 247 64107784
Restless legs syndrome 13.98 9.80 162 390539 16954 64091077
Hair colour changes 13.96 9.80 52 390649 3675 64104356
Skin ulcer 13.94 9.80 185 390516 43789 64064242
Seborrhoeic keratosis 13.80 9.80 35 390666 2005 64106026
Palmar-plantar erythrodysaesthesia syndrome 13.77 9.80 110 390591 28709 64079322
Gastric ulcer 13.72 9.80 117 390584 30117 64077914
Wrong patient received product 13.71 9.80 3 390698 3759 64104272
Hepatitis B 13.70 9.80 16 390685 7729 64100302
Bradyarrhythmia 13.69 9.80 3 390698 3755 64104276
Atrioventricular block 13.68 9.80 33 390668 11982 64096049
Proteinuria 13.63 9.80 105 390596 27618 64080413
Nephrectomy 13.62 9.80 28 390673 1394 64106637
Myocarditis 13.61 9.80 55 390646 16988 64091043
Complications of transplanted kidney 13.61 9.80 8 390693 5427 64102604
Wrong product administered 13.61 9.80 16 390685 7704 64100327
Nerve degeneration 13.51 9.80 12 390689 259 64107772
Accidental death 13.51 9.80 3 390698 3722 64104309
Temperature intolerance 13.49 9.80 91 390610 8164 64099867
Lymph node pain 13.40 9.80 27 390674 1325 64106706
Weight fluctuation 13.36 9.80 91 390610 8191 64099840
Head banging 13.35 9.80 16 390685 496 64107535
Cataract operation 13.35 9.80 52 390649 3754 64104277
Impaired work ability 13.32 9.80 146 390555 15073 64092958
Hepatitis toxic 13.29 9.80 5 390696 4395 64103636
Feeling jittery 13.28 9.80 110 390591 10525 64097506
Adverse drug reaction 13.22 9.80 365 390336 45099 64062932
Eye pain 13.22 9.80 267 390434 31358 64076673
Cardiovascular somatic symptom disorder 13.22 9.80 6 390695 36 64107995
Lung hernia 13.15 9.80 7 390694 62 64107969
Multiple-drug resistance 13.13 9.80 12 390689 6490 64101541
Open reduction of fracture 13.12 9.80 11 390690 219 64107812
Restlessness 13.12 9.80 166 390535 39619 64068412
Viral upper respiratory tract infection 13.09 9.80 90 390611 8125 64099906
Tenosynovitis 13.08 9.80 33 390668 11800 64096231
Methaemoglobinaemia 13.03 9.80 5 390696 4343 64103688
Intestinal stenosis 13.02 9.80 46 390655 3168 64104863
Vaginal haematoma 12.99 9.80 9 390692 133 64107898
Chronic disease 12.96 9.80 8 390693 96 64107935
Haemorrhage intracranial 12.93 9.80 88 390613 23796 64084235
Congestive hepatopathy 12.89 9.80 4 390697 3969 64104062
Exposure to toxic agent 12.88 9.80 11 390690 6148 64101883
Chronic left ventricular failure 12.85 9.80 19 390682 725 64107306
Laboratory test abnormal 12.81 9.80 211 390490 23852 64084179
Nephrotic syndrome 12.80 9.80 24 390677 9543 64098488
Hyperparathyroidism secondary 12.77 9.80 37 390664 2293 64105738
Vestibular migraine 12.77 9.80 9 390692 137 64107894
Axial spondyloarthritis 12.75 9.80 14 390687 394 64107637
Staphylococcal sepsis 12.75 9.80 38 390663 12861 64095170
Cardiac failure chronic 12.70 9.80 22 390679 9019 64099012
Lymphadenitis 12.70 9.80 51 390650 3734 64104297
Electrolyte imbalance 12.70 9.80 95 390606 25148 64082883
Eye infection 12.68 9.80 98 390603 9183 64098848
Neutrophil percentage increased 12.68 9.80 57 390644 4388 64103643
Pneumatosis intestinalis 12.67 9.80 8 390693 5221 64102810
Bone marrow oedema 12.65 9.80 24 390677 1126 64106905
Pseudomembranous colitis 12.64 9.80 7 390694 4909 64103122
Sensory disturbance 12.63 9.80 129 390572 13079 64094952
Respiratory symptom 12.63 9.80 44 390657 3009 64105022
Multiple allergies 12.63 9.80 69 390632 5745 64102286
Eye contusion 12.60 9.80 33 390668 1928 64106103
Stress cardiomyopathy 12.58 9.80 23 390678 9234 64098797
Invasive lobular breast carcinoma 12.55 9.80 16 390685 529 64107502
Colonoscopy 12.55 9.80 30 390671 1655 64106376
Mucous stools 12.54 9.80 46 390655 3227 64104804
Hepatic enzyme increased 12.54 9.80 651 390050 129292 63978739
Eructation 12.53 9.80 97 390604 9094 64098937
Conjunctival hyperaemia 12.52 9.80 4 390697 3895 64104136
Polyomavirus-associated nephropathy 12.52 9.80 7 390694 4881 64103150
Klebsiella infection 12.50 9.80 40 390661 13241 64094790
Product dose omission in error 12.49 9.80 39 390662 2520 64105511
Cardiomegaly 12.46 9.80 88 390613 23596 64084435
Polyneuropathy idiopathic progressive 12.45 9.80 4 390697 7 64108024
Blood 25-hydroxycholecalciferol increased 12.45 9.80 4 390697 7 64108024
Prothrombin time prolonged 12.44 9.80 51 390650 15690 64092341
Faeces soft 12.39 9.80 69 390632 5786 64102245
Post procedural stroke 12.35 9.80 8 390693 105 64107926
Metastases to central nervous system 12.34 9.80 43 390658 13869 64094162
Adenosquamous cell lung cancer stage IV 12.34 9.80 3 390698 0 64108031
Radical mastectomy 12.34 9.80 3 390698 0 64108031
Squamous cell carcinoma of skin 12.34 9.80 118 390583 11758 64096273
Ill-defined disorder 12.32 9.80 190 390511 43862 64064169
Pancreatic neuroendocrine tumour 12.32 9.80 15 390686 473 64107558
Cytomegalovirus test positive 12.28 9.80 8 390693 5136 64102895
Long QT syndrome 12.26 9.80 8 390693 5131 64102900
Rash pruritic 12.26 9.80 444 390257 56960 64051071
Vulvovaginal burning sensation 12.23 9.80 24 390677 1155 64106876
Trigeminal neuralgia 12.17 9.80 44 390657 3065 64104966
Diffuse large B-cell lymphoma 12.16 9.80 28 390673 10333 64097698
Antipsychotic drug level increased 12.15 9.80 8 390693 5107 64102924
Gingival discolouration 12.15 9.80 10 390691 194 64107837
Meniscus injury 12.09 9.80 69 390632 5838 64102193
Aortic dissection 12.09 9.80 3 390698 3449 64104582
Magnetic resonance imaging abnormal 12.06 9.80 44 390657 3079 64104952
Inflammatory bowel disease 12.06 9.80 57 390644 4481 64103550
Thyroxine free increased 12.05 9.80 23 390678 1084 64106947
Dysarthria 12.01 9.80 271 390430 59135 64048896
Red blood cell count increased 12.01 9.80 48 390653 3507 64104524
Bronchial disorder 12.00 9.80 34 390667 2081 64105950
Emotional disorder 12.00 9.80 123 390578 12484 64095547
Mitral valve incompetence 11.96 9.80 98 390603 25440 64082591
Pneumothorax 11.96 9.80 92 390609 24206 64083825
Hypogammaglobulinaemia 11.96 9.80 28 390673 10271 64097760
Therapy interrupted 11.92 9.80 179 390522 19857 64088174
Nystagmus 11.91 9.80 23 390678 9045 64098986
Ligament sprain 11.86 9.80 109 390592 10743 64097288
Skin warm 11.85 9.80 67 390634 5650 64102381
Duodenitis 11.85 9.80 14 390687 6727 64101304
Osteocalcin decreased 11.79 9.80 4 390697 9 64108022
Skin atrophy 11.79 9.80 60 390641 4860 64103171
Eustachian tube obstruction 11.78 9.80 6 390695 48 64107983
Stomatitis 11.77 9.80 543 390158 109062 63998969
Lymphocyte count abnormal 11.76 9.80 20 390681 861 64107170
Hepatorenal syndrome 11.75 9.80 4 390697 3742 64104289
Ear discomfort 11.75 9.80 80 390621 7200 64100831
Therapeutic response decreased 11.74 9.80 234 390467 51954 64056077
Kidney transplant rejection 11.74 9.80 25 390676 9486 64098545
Joint swelling 11.71 9.80 1483 389218 213899 63894132
Musculoskeletal chest pain 11.68 9.80 189 390512 21290 64086741
Cross sensitivity reaction 11.65 9.80 3 390698 3364 64104667
Bronchial haemorrhage 11.63 9.80 24 390677 1198 64106833
Adrenal insufficiency 11.61 9.80 84 390617 22403 64085628
Hyperuricaemia 11.60 9.80 28 390673 10163 64097868
Choking 11.60 9.80 106 390595 10432 64097599
Endometrial hypertrophy 11.59 9.80 9 390692 160 64107871
Pneumonitis 11.58 9.80 225 390476 50140 64057891
Subileus 11.54 9.80 8 390693 4969 64103062
Cardiac failure congestive 11.52 9.80 660 390041 129920 63978111
Condition aggravated 11.51 9.80 2487 388214 369939 63738092
Cerebral haematoma 11.51 9.80 16 390685 7169 64100862
Periarthritis 11.51 9.80 38 390663 2529 64105502
Enzyme level decreased 11.50 9.80 4 390697 10 64108021
Pulmonary congestion 11.48 9.80 91 390610 23789 64084242
Alveolitis 11.48 9.80 4 390697 3688 64104343
Lipodystrophy acquired 11.47 9.80 5 390696 4022 64104009
Dermatitis acneiform 11.45 9.80 21 390680 8422 64099609
Vitamin D abnormal 11.45 9.80 8 390693 120 64107911
Abdominal adhesions 11.42 9.80 42 390659 2950 64105081
Lung disorder 11.41 9.80 280 390421 60420 64047611
Tooth infection 11.40 9.80 137 390564 14464 64093567
Limb injury 11.39 9.80 203 390498 23302 64084729
Nail bed disorder 11.37 9.80 10 390691 213 64107818
Carbohydrate antigen 15-3 increased 11.36 9.80 21 390680 966 64107065
Crepitations 11.36 9.80 19 390682 7896 64100135
Skin exfoliation 11.32 9.80 354 390347 44531 64063500
Emotional distress 11.28 9.80 152 390549 35886 64072145
Throat clearing 11.27 9.80 25 390676 1313 64106718
Duodenal ulcer haemorrhage 11.26 9.80 13 390688 6312 64101719
Panniculitis 11.25 9.80 23 390678 8856 64099175
Disseminated tuberculosis 11.25 9.80 4 390697 3641 64104390
Thyroid cancer 11.25 9.80 51 390650 3940 64104091
Feeding disorder 11.23 9.80 124 390577 12825 64095206
Weight bearing difficulty 11.22 9.80 39 390662 2664 64105367
Catatonia 11.21 9.80 18 390683 7602 64100429
Ocular discomfort 11.19 9.80 51 390650 3948 64104083
Stupor 11.19 9.80 12 390689 6023 64102008
Uterine leiomyoma 11.18 9.80 63 390638 5306 64102725
Metastases to liver 11.16 9.80 92 390609 23849 64084182
Premature baby 11.16 9.80 3 390698 3269 64104762
Intestinal mass 11.15 9.80 22 390679 1063 64106968
Post procedural hypothyroidism 11.13 9.80 7 390694 87 64107944
Somnolence 11.11 9.80 1072 389629 202573 63905458
Dairy intolerance 11.09 9.80 6 390695 55 64107976
Obstruction 11.09 9.80 44 390657 3204 64104827
Epigastric discomfort 11.08 9.80 75 390626 6736 64101295
Acute graft versus host disease in intestine 11.07 9.80 4 390697 3605 64104426
Sensory loss 11.04 9.80 102 390599 10067 64097964
Brain herniation 11.03 9.80 14 390687 6519 64101512
Spinal cord injury lumbar 10.91 9.80 6 390695 57 64107974
Tooth loss 10.90 9.80 70 390631 6177 64101854
Creatinine renal clearance increased 10.86 9.80 19 390682 837 64107194
Pleural fibrosis 10.86 9.80 51 390650 3999 64104032
Jaw disorder 10.85 9.80 56 390645 4561 64103470
Neoplasm progression 10.84 9.80 325 390376 40639 64067392
Hyperaesthesia teeth 10.83 9.80 27 390674 1530 64106501
Premature delivery 10.82 9.80 67 390634 18522 64089509
Electrocardiogram ST segment elevation 10.82 9.80 17 390684 7242 64100789
Blood creatinine increased 10.80 9.80 693 390008 135089 63972942
Lung consolidation 10.79 9.80 19 390682 7739 64100292
Blood pressure systolic abnormal 10.78 9.80 28 390673 9914 64098117
Device related infection 10.78 9.80 126 390575 30500 64077531
Vitamin B complex deficiency 10.75 9.80 13 390688 407 64107624
Intestinal obstruction 10.74 9.80 292 390409 35994 64072037
Immunoglobulins increased 10.73 9.80 14 390687 474 64107557
Initial insomnia 10.73 9.80 66 390635 5738 64102293
Right ventricular failure 10.71 9.80 81 390620 21390 64086641
SARS-CoV-2 test positive 10.70 9.80 70 390631 6216 64101815
Embolic stroke 10.70 9.80 15 390686 6696 64101335
Blood 25-hydroxycholecalciferol decreased 10.66 9.80 9 390692 181 64107850
Muscle twitching 10.64 9.80 168 390533 18830 64089201
Feeling cold 10.60 9.80 202 390499 23476 64084555
Distal intestinal obstruction syndrome 10.60 9.80 16 390685 622 64107409
Graft versus host disease in gastrointestinal tract 10.58 9.80 11 390690 5601 64102430
Hypophosphataemic osteomalacia 10.53 9.80 11 390690 292 64107739
Hereditary angioedema 10.53 9.80 49 390652 3827 64104204
Pernicious anaemia 10.51 9.80 15 390686 554 64107477
Trichorrhexis 10.49 9.80 17 390684 703 64107328
Sleep disorder due to general medical condition, insomnia type 10.48 9.80 105 390596 26165 64081866
Pericardial haemorrhage 10.48 9.80 6 390695 4130 64103901
Cardiac tamponade 10.47 9.80 21 390680 8143 64099888
Skin sensitisation 10.47 9.80 18 390683 782 64107249
Breast pain 10.46 9.80 76 390625 6985 64101046
Ventricular arrhythmia 10.46 9.80 18 390683 7397 64100634
Drug delivery device placement 10.46 9.80 9 390692 186 64107845
Rebound effect 10.44 9.80 58 390643 4859 64103172
Hypoxic-ischaemic encephalopathy 10.42 9.80 17 390684 7135 64100896
C-reactive protein abnormal 10.42 9.80 119 390582 28928 64079103
pH urine increased 10.41 9.80 13 390688 421 64107610
Melanocytic naevus 10.41 9.80 51 390650 4069 64103962
Appendicolith 10.38 9.80 4 390697 3465 64104566
High turnover osteopathy 10.38 9.80 5 390696 35 64107996
Virologic failure 10.36 9.80 4 390697 3462 64104569
Cardioactive drug level increased 10.36 9.80 4 390697 3461 64104570
Anal incontinence 10.34 9.80 139 390562 15057 64092974
Toe operation 10.33 9.80 14 390687 492 64107539
Gingival operation 10.32 9.80 6 390695 64 64107967
Ventricular dysfunction 10.32 9.80 10 390691 5260 64102771
Gastric volvulus 10.31 9.80 4 390697 15 64108016
Metastatic renal cell carcinoma 10.29 9.80 33 390668 2163 64105868
Bone cyst 10.28 9.80 33 390668 2164 64105867
Pain threshold decreased 10.28 9.80 3 390698 3 64108028
Catheterisation venous 10.28 9.80 3 390698 3 64108028
Decreased interest 10.28 9.80 44 390657 3316 64104715
Ear disorder 10.15 9.80 42 390659 3118 64104913
Specific gravity urine increased 10.13 9.80 13 390688 433 64107598
Diabetes mellitus 10.09 9.80 316 390385 66158 64041873
Humerus fracture 10.08 9.80 82 390619 7803 64100228
Gynaecomastia 10.04 9.80 13 390688 6003 64102028
Intestinal resection 10.03 9.80 41 390660 3027 64105004
Acute lymphocytic leukaemia recurrent 9.97 9.80 6 390695 4020 64104011
Crystal urine present 9.97 9.80 30 390671 1899 64106132
Urinary sediment present 9.95 9.80 33 390668 2201 64105830
Eating disorder 9.95 9.80 150 390551 16655 64091376
Intentional product use issue 9.94 9.80 688 390013 94676 64013355
Atopy 9.93 9.80 10 390691 254 64107777
Osteoporosis postmenopausal 9.92 9.80 4 390697 17 64108014
C-telopeptide increased 9.92 9.80 4 390697 17 64108014
Pseudomonal sepsis 9.91 9.80 10 390691 5162 64102869
Mole excision 9.90 9.80 7 390694 107 64107924
Hepatitis B reactivation 9.90 9.80 9 390692 4880 64103151
Alcohol use 9.89 9.80 8 390693 4594 64103437
Fibula fracture 9.88 9.80 41 390660 3047 64104984
Blood electrolytes decreased 9.87 9.80 23 390678 1248 64106783
Neutrophil count decreased 9.86 9.80 375 390326 76821 64031210
Aphonia 9.83 9.80 88 390613 8609 64099422
Intracranial pressure increased 9.83 9.80 17 390684 6972 64101059
Colporrhaphy 9.82 9.80 3 390698 4 64108027
Mandibular mass 9.81 9.80 9 390692 203 64107828
Dermatitis atopic 9.80 9.80 48 390653 3828 64104203

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CC01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
FDA CS M0007651 Ergocalciferols
MeSH PA D050071 Bone Density Conservation Agents
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins
FDA EPC N0000175909 Provitamin D2 Compound
CHEBI has role CHEBI:33288 rodenticides
CHEBI has role CHEBI:50646 antiosteoporotic
CHEBI has role CHEBI:50733 Dietary Supplement
CHEBI has role CHEBI:76924 plant metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteomalacia indication 4598005 DOID:10573
Hypocalcemia indication 5291005
Vitamin D deficiency indication 34713006
Hypoparathyroidism indication 36976004 DOID:11199
Rickets indication 41345002 DOID:10609
Osteoporosis indication 64859006 DOID:11476
Familial x-linked hypophosphatemic vitamin D refractory rickets indication 82236004
Vitamin deficiency indication 85670002
Postmenopausal osteoporosis indication 102447009
Prevention of dental caries indication 426482000
Vitamin Deficiency Prevention indication
Hyperparathyroidism Secondary to Chronic Renal Failure with Dialysis indication
Hypogonadal Osteoporosis in Males indication
Vitamin D Dependent Rickets indication
Glucocorticoid Induced Osteoporosis indication
Renal osteodystrophy off-label use 16726004 DOID:13068
Hyperparathyroidism Secondary to Chronic Renal Failure off-label use
Anticonvulsant-induced Osteomalacia off-label use
Gastritis contraindication 4556007 DOID:4029
Poisoning by digitalis glycoside contraindication 12876009
Constipation contraindication 14760008 DOID:2089
Esophagitis contraindication 16761005 DOID:11963
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Dental fluorosis contraindication 30265004
Ulcer of esophagus contraindication 30811009
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Atrial fibrillation contraindication 49436004 DOID:0060224
Vitamin E deficiency contraindication 54137008
Hyperlipidemia contraindication 55822004 DOID:1168
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Stricture of esophagus contraindication 63305008
Hypervitaminosis A contraindication 64559002 DOID:9972
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Fracture of femur contraindication 71620000
Hypercalciuria contraindication 71938000
Duodenitis contraindication 72007001 DOID:8643
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Neoplasm of endometrium contraindication 123844007 DOID:1380
Neoplasm of prostate contraindication 126906006 DOID:10283
Hb SS disease contraindication 127040003 DOID:10923
Bed-ridden contraindication 160685001
Acute peptic ulcer contraindication 196682000
Osteolysis contraindication 203522001
Disease of liver contraindication 235856003 DOID:409
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Malignant tumor of cervix contraindication 363354003 DOID:4362
Hemochromatosis contraindication 399187006 DOID:2352
Central nervous system depression contraindication 418072004
Aseptic necrosis of bone of jaw contraindication 441809006
Carcinoma of female breast contraindication 447782002
Malabsorption States contraindication
High Grade Dysplasia associated with Barrett's Esophagus contraindication
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication
Esophageal Obstruction contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST WOMBAT-PK CHEMBL
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Enzyme WOMBAT-PK
Vitamin D 25-hydroxylase Enzyme WOMBAT-PK

External reference:

IDSource
4017629 VUID
N0000146009 NUI
D00187 KEGG_DRUG
4017629 VANDF
4017649 VANDF
4021908 VANDF
C0014695 UMLSCUI
CHEBI:28934 CHEBI
D2V PDB_CHEM_ID
CHEMBL1536 ChEMBL_ID
DB00153 DRUGBANK_ID
5280793 PUBCHEM_CID
382 INN_ID
VS041H42XC UNII
DB11094 DRUGBANK_ID
11253 RXNORM
1067 MMSL
335232 MMSL
3554 MMSL
4671 MMSL
5688 MMSL
6150 MMSL
d03128 MMSL
001013 NDDF
11563006 SNOMEDCT_US
23433006 SNOMEDCT_US
30178006 SNOMEDCT_US
71516007 SNOMEDCT_US
D004872 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 10544-527 CAPSULE 1.25 mg ORAL ANDA 19 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 23155-809 CAPSULE 1.25 mg ORAL ANDA 16 sections
DRISDOL HUMAN PRESCRIPTION DRUG LABEL 1 30698-493 CAPSULE, LIQUID FILLED 1.25 mg ORAL NDA 19 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 33261-730 CAPSULE 1.25 mg ORAL ANDA 19 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 42291-266 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 20 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 42794-006 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 19 sections
Ergocalciferol Capsules, HUMAN PRESCRIPTION DRUG LABEL 1 42806-547 CAPSULE 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 43063-711 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 43063-711 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 43353-219 CAPSULE 1.25 mg ORAL ANDA 19 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 43353-238 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 20 sections
VITAMIN D Human Prescription Drug Label 1 43353-828 CAPSULE 1.25 mg ORAL ANDA 19 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 50090-3201 CAPSULE 1.25 1 ORAL ANDA 15 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 50090-4382 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 19 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 50090-5844 CAPSULE 1.25 mg ORAL ANDA 18 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 50268-297 CAPSULE 1.25 mg ORAL ANDA 15 sections
ERGOCALCIFEROL HUMAN PRESCRIPTION DRUG LABEL 1 51407-143 CAPSULE 1.25 mg ORAL ANDA 18 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 53217-287 CAPSULE 1.25 mg ORAL ANDA 16 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 54868-5799 CAPSULE 1.25 mg ORAL ANDA 11 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 60687-500 CAPSULE 1.25 mg ORAL ANDA 19 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 60760-152 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 18 sections
Ergocalciferol Capsules, HUMAN PRESCRIPTION DRUG LABEL 1 60760-275 CAPSULE 1.25 mg ORAL ANDA 18 sections
Vitamin D HUMAN PRESCRIPTION DRUG LABEL 1 61919-702 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 10 sections
ERGOCALCIFEROL Human Prescription Drug Label 1 62332-464 CAPSULE 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 63187-064 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 11 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 63187-519 CAPSULE 1.25 mg ORAL ANDA 16 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 63187-519 CAPSULE 1.25 mg ORAL ANDA 16 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 63629-2447 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 63629-2447 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 63629-7913 CAPSULE 1.25 mg ORAL ANDA 18 sections