ergocalciferol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 2838 50-14-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ergocalciferol
  • vitamin D2
  • calciferol
  • ercalciol
  • ergorone
  • Molecular weight: 396.66
  • Formula: C28H44O
  • CLOGP: 9.39
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -5.96
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.86 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 77 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK10,MAPK7,NTRK2,PDK2,PDK4,PRKDC,TEK,TGFBR1 19
kinase-selectivity-class GRK2 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Jan. 11, 1941 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1144.35 9.73 422 715827 287424 89624774
Completed suicide 714.84 9.73 139 716110 144919 89767279
Drug interaction 530.81 9.73 853 715396 275600 89636598
Intentional overdose 528.53 9.73 61 716188 93773 89818425
Acute kidney injury 435.01 9.73 1203 715046 319184 89593014
Drug ineffective 413.99 9.73 8091 708158 1376207 88535991
Drug abuse 409.68 9.73 77 716172 82270 89829928
Overdose 392.28 9.73 400 715849 157309 89754889
Multiple sclerosis relapse 323.08 9.73 1029 715220 51276 89860922
Product dose omission issue 302.22 9.73 3580 712669 288107 89624091
Thrombocytopenia 298.84 9.73 763 715486 207962 89704236
Myelosuppression 250.32 9.73 58 716191 53533 89858665
Febrile neutropenia 237.48 9.73 565 715684 157784 89754414
Multiple organ dysfunction syndrome 233.73 9.73 124 716125 68212 89843986
Suicide attempt 226.96 9.73 159 716090 75240 89836958
Hypotension 226.12 9.73 1573 714676 323824 89588374
Hyponatraemia 218.65 9.73 454 715795 133084 89779114
Cardiac arrest 218.42 9.73 306 715943 104629 89807569
Exposure during pregnancy 218.40 9.73 1054 715195 237356 89674842
Hepatic function abnormal 218.39 9.73 49 716200 46239 89865959
Cardio-respiratory arrest 213.86 9.73 116 716133 63024 89849174
Pancytopenia 208.84 9.73 395 715854 119868 89792330
Back pain 199.85 9.73 3570 712679 313605 89598593
Hepatic cytolysis 199.26 9.73 11 716238 30905 89881293
Drug reaction with eosinophilia and systemic symptoms 198.27 9.73 47 716202 42711 89869487
Depressed level of consciousness 198.11 9.73 170 716079 72614 89839584
Muscle spasms 195.77 9.73 2935 713314 248948 89663250
Neutropenia 191.92 9.73 1019 715230 223885 89688313
Asthma 182.89 9.73 2808 713441 239352 89672846
Fatigue 182.39 9.73 10991 705258 1143032 88769166
Hyperkalaemia 175.28 9.73 153 716096 64811 89847387
Septic shock 173.57 9.73 247 716002 83913 89828285
Cardiac failure 169.52 9.73 384 715865 109112 89803086
Mucosal inflammation 165.04 9.73 128 716121 57497 89854701
Lactic acidosis 164.74 9.73 97 716152 50366 89861832
Hypokalaemia 164.16 9.73 511 715738 130605 89781593
Headache 162.48 9.73 8352 707897 854394 89057804
Respiratory failure 150.74 9.73 458 715791 117960 89794238
Pain in extremity 146.84 9.73 4628 711621 445901 89466297
Multiple sclerosis 146.48 9.73 519 715730 27321 89884877
Metabolic acidosis 145.57 9.73 135 716114 55541 89856657
Agranulocytosis 144.59 9.73 48 716201 34954 89877244
Infective pulmonary exacerbation of cystic fibrosis 142.82 9.73 276 715973 10003 89902195
Contraindicated product administered 137.63 9.73 1744 714505 318395 89593803
Bradycardia 137.28 9.73 285 715964 83562 89828636
Rhabdomyolysis 136.73 9.73 122 716127 51134 89861064
Maternal exposure during pregnancy 136.65 9.73 2012 714237 358051 89554147
Malignant neoplasm progression 134.84 9.73 415 715834 106455 89805743
Fall 134.11 9.73 4859 711390 476951 89435247
Electrocardiogram QT prolonged 133.83 9.73 229 716020 72227 89839971
Muscle spasticity 133.76 9.73 594 715655 34728 89877470
Wheezing 131.68 9.73 2627 713622 235453 89676745
Influenza like illness 131.52 9.73 1088 715161 79523 89832675
Intentional self-injury 130.69 9.73 35 716214 29299 89882899
Feeling abnormal 129.97 9.73 1949 714300 165286 89746912
Hepatocellular injury 128.16 9.73 35 716214 28923 89883275
Angioedema 127.36 9.73 197 716052 64679 89847519
Coma 126.57 9.73 238 716011 72394 89839804
Bone pain 126.06 9.73 881 715368 61102 89851096
Cholestasis 119.59 9.73 69 716180 36230 89875968
Hypoaesthesia 117.00 9.73 3282 712967 310928 89601270
Diarrhoea 114.94 9.73 8759 707490 930431 88981767
Anaemia 114.37 9.73 2030 714219 350772 89561426
Cytomegalovirus infection 110.73 9.73 36 716213 26566 89885632
Insomnia 108.13 9.73 3424 712825 330050 89582148
Nasal oedema 108.12 9.73 190 716059 6394 89905804
Infusion related reaction 107.95 9.73 2489 713760 414291 89497907
Body height decreased 107.05 9.73 269 715980 11680 89900518
Serotonin syndrome 106.17 9.73 86 716163 37801 89874397
Cytokine release syndrome 106.07 9.73 44 716205 27929 89884269
Sepsis 104.77 9.73 912 715337 178902 89733296
Vitamin D decreased 104.53 9.73 267 715982 11712 89900486
Dermatitis atopic 103.90 9.73 414 715835 23058 89889140
Drug intolerance 103.68 9.73 2718 713531 444873 89467325
Glossodynia 103.49 9.73 1854 714395 319925 89592273
Gait disturbance 103.48 9.73 2744 713505 257752 89654446
Death 102.73 9.73 2784 713465 453767 89458431
Rash maculo-papular 102.65 9.73 103 716146 40830 89871368
Foetal exposure during pregnancy 102.32 9.73 113 716136 42862 89869336
White blood cell count decreased 102.31 9.73 1873 714376 165236 89746962
Anaphylactic shock 101.48 9.73 62 716187 31555 89880643
Carpal tunnel syndrome 101.11 9.73 416 715833 23512 89888686
Psoriatic arthropathy 100.64 9.73 2439 713810 225896 89686302
Leukopenia 98.21 9.73 435 715814 100275 89811923
Systemic lupus erythematosus 98.02 9.73 2146 714103 359750 89552448
Vitamin D deficiency 97.31 9.73 333 715916 17223 89894975
Asthenia 97.07 9.73 5152 711097 528599 89383599
Altered state of consciousness 96.87 9.73 65 716184 31467 89880731
Pemphigus 96.25 9.73 1912 714337 324952 89587246
Rhinorrhoea 96.19 9.73 1095 715154 87221 89824977
Memory impairment 95.58 9.73 2135 714114 195109 89717089
Hepatic failure 95.09 9.73 104 716145 39624 89872574
Tachycardia 94.85 9.73 793 715456 156880 89755318
Neutropenic sepsis 94.44 9.73 15 716234 18115 89894083
Foetal death 93.70 9.73 24 716225 20699 89891499
Shock 92.97 9.73 56 716193 28722 89883476
Rheumatoid arthritis 92.64 9.73 3623 712626 358991 89553207
Neuroleptic malignant syndrome 92.46 9.73 7 716242 15089 89897109
Anaphylactic reaction 92.18 9.73 367 715882 87157 89825041
Hepatotoxicity 91.13 9.73 138 716111 45704 89866494
Bone marrow failure 89.22 9.73 74 716175 32147 89880051
Temperature regulation disorder 88.62 9.73 7 716242 14572 89897626
Full blood count decreased 88.42 9.73 466 715783 29223 89882975
Sensitisation 88.20 9.73 135 716114 4040 89908158
Renal failure 88.09 9.73 639 715610 130368 89781830
Acute hepatic failure 87.98 9.73 34 716215 22527 89889671
Abdominal pain upper 87.84 9.73 3336 712913 329338 89582860
Sedation 87.36 9.73 154 716095 48017 89864181
Dry skin 87.10 9.73 1072 715177 87001 89825197
Toxic skin eruption 86.97 9.73 11 716238 15763 89896435
Burning sensation 86.27 9.73 823 715426 62629 89849569
Hand deformity 85.91 9.73 1738 714511 294624 89617574
Gastrooesophageal reflux disease 85.86 9.73 1817 714432 164520 89747678
Full blood count abnormal 85.80 9.73 539 715710 36058 89876140
Stevens-Johnson syndrome 85.72 9.73 64 716185 29312 89882886
Sinusitis 85.54 9.73 3419 712830 339669 89572529
Muscular weakness 85.25 9.73 2188 714061 204478 89707720
Neurotoxicity 84.29 9.73 32 716217 21435 89890763
Oedema 83.93 9.73 2125 714124 198170 89714028
Cough 83.18 9.73 3638 712611 365324 89546874
Posterior reversible encephalopathy syndrome 81.74 9.73 37 716212 22302 89889896
Cerebral infarction 81.47 9.73 55 716194 26541 89885657
Paraesthesia 80.75 9.73 2569 713680 247757 89664441
Premature delivery 80.67 9.73 113 716136 38649 89873549
Sinus disorder 80.55 9.73 507 715742 33940 89878258
Ear pain 80.23 9.73 752 715497 56950 89855248
Influenza 79.74 9.73 1545 714704 137719 89774479
Cardiogenic shock 78.50 9.73 48 716201 24420 89887778
Sleep apnoea syndrome 78.47 9.73 474 715775 31273 89880925
Drug resistance 78.23 9.73 75 716174 30374 89881824
Hypoglycaemia 77.34 9.73 287 715962 69561 89842637
Disease progression 76.58 9.73 829 715420 155786 89756412
Poisoning 76.16 9.73 14 716235 15203 89896995
Blood test abnormal 76.07 9.73 348 715901 20604 89891594
Night sweats 75.93 9.73 1435 714814 127331 89784867
Acute respiratory distress syndrome 75.65 9.73 69 716180 28617 89883581
Pyrexia 75.59 9.73 4360 711889 656125 89256073
Psoriasis 75.28 9.73 1611 714638 146143 89766055
Polycystic ovaries 75.14 9.73 149 716100 5505 89906693
Respiratory depression 74.45 9.73 16 716233 15559 89896639
COVID-19 74.21 9.73 1803 714446 167040 89745158
Torsade de pointes 73.80 9.73 15 716234 15167 89897031
Jaundice 71.53 9.73 91 716158 32426 89879772
Interstitial lung disease 70.93 9.73 336 715913 76069 89836129
Hip fracture 70.72 9.73 476 715773 32601 89879597
Ejection fraction 70.26 9.73 102 716147 2909 89909289
Drug ineffective for unapproved indication 69.83 9.73 280 715969 66364 89845834
Encephalopathy 69.36 9.73 166 716083 46278 89865920
Ventricular tachycardia 69.34 9.73 56 716193 24652 89887546
Circulatory collapse 69.20 9.73 57 716192 24847 89887351
Agitation 68.99 9.73 284 715965 66814 89845384
Mydriasis 68.62 9.73 17 716232 14995 89897203
Acute generalised exanthematous pustulosis 67.74 9.73 13 716236 13690 89898508
Respiratory arrest 67.46 9.73 99 716150 33212 89878986
General physical health deterioration 66.54 9.73 2219 714030 352896 89559302
Colitis ulcerative 66.42 9.73 749 715500 59517 89852681
Blood calcium increased 66.21 9.73 228 716021 11830 89900368
Sleep disorder due to a general medical condition 65.71 9.73 590 715659 44148 89868050
Ejection fraction decreased 64.76 9.73 67 716182 26186 89886012
Extrapyramidal disorder 64.52 9.73 24 716225 16279 89895919
Pleural effusion 64.33 9.73 570 715679 111421 89800777
Gastrointestinal haemorrhage 64.19 9.73 433 715816 89815 89822383
Ascites 63.37 9.73 181 716068 47559 89864639
Spinal fracture 63.13 9.73 342 715907 21674 89890524
Bone giant cell tumour 62.97 9.73 23 716226 48 89912150
Arthralgia 62.88 9.73 7049 709200 771473 89140725
Urinary tract infection 62.86 9.73 2986 713263 302646 89609552
Limb discomfort 62.76 9.73 515 715734 37545 89874653
Thrombotic microangiopathy 62.60 9.73 23 716226 15720 89896478
Pneumocystis jirovecii pneumonia 61.91 9.73 48 716201 21568 89890630
Haematotoxicity 61.74 9.73 12 716237 12523 89899675
Nasal congestion 61.25 9.73 963 715286 82451 89829747
Psychotic disorder 61.13 9.73 95 716154 31135 89881063
Haemophagocytic lymphohistiocytosis 60.77 9.73 23 716226 15436 89896762
Face oedema 60.41 9.73 57 716192 23261 89888937
Blood bilirubin increased 59.79 9.73 162 716087 43308 89868890
Respiratory tract congestion 59.53 9.73 396 715853 27014 89885184
Weight decreased 59.44 9.73 3618 712631 376292 89535906
Skin haemorrhage 59.21 9.73 329 715920 21051 89891147
Cataract 58.64 9.73 847 715402 71245 89840953
Anxiety 58.40 9.73 3001 713248 306771 89605427
Febrile bone marrow aplasia 58.30 9.73 5 716244 9733 89902465
Depression 58.28 9.73 2920 713329 297681 89614517
Cardiotoxicity 58.04 9.73 10 716239 11379 89900819
Jaundice cholestatic 57.88 9.73 6 716243 10037 89902161
Gait inability 57.32 9.73 1540 714709 144916 89767282
Toxic epidermal necrolysis 57.18 9.73 106 716143 32422 89879776
Respiratory tract infection 57.08 9.73 716 715533 58362 89853836
Constipation 56.92 9.73 2736 713513 277659 89634539
Recalled product 56.36 9.73 62 716187 1326 89910872
Liver function test abnormal 56.24 9.73 209 716040 50636 89861562
Pollakiuria 55.72 9.73 449 715800 32556 89879642
Myoclonus 55.62 9.73 42 716207 19126 89893072
Melaena 55.51 9.73 120 716129 34677 89877521
Injection site pain 55.30 9.73 1780 714469 171919 89740279
Loss of consciousness 54.73 9.73 779 715470 139459 89772739
Accidental overdose 54.40 9.73 87 716162 28186 89884012
Generalised tonic-clonic seizure 54.33 9.73 122 716127 34781 89877417
Bronchopulmonary aspergillosis 53.90 9.73 12 716237 11386 89900812
Osteopenia 53.43 9.73 338 715911 22664 89889534
Ventricular fibrillation 53.39 9.73 22 716227 14022 89898176
Disseminated intravascular coagulation 53.09 9.73 55 716194 21483 89890715
Myalgia 52.77 9.73 1783 714466 173342 89738856
Status epilepticus 52.69 9.73 43 716206 18831 89893367
Intentional product misuse 52.37 9.73 454 715795 89150 89823048
Food allergy 52.30 9.73 75 716174 25403 89886795
Premature baby 52.29 9.73 73 716176 25004 89887194
Treatment failure 51.45 9.73 1923 714326 302005 89610193
Device expulsion 51.39 9.73 159 716090 40727 89871471
Plasma cell myeloma 51.32 9.73 521 715728 40307 89871891
Product administration interrupted 51.07 9.73 215 716034 12277 89899921
Ischaemic stroke 50.90 9.73 60 716189 22106 89890092
International normalised ratio increased 50.71 9.73 197 716052 47119 89865079
Mycotic allergy 50.66 9.73 52 716197 1024 89911174
Nasopharyngitis 50.57 9.73 3803 712446 403301 89508897
Dry mouth 50.51 9.73 1854 714395 182205 89729993
Seizure 50.41 9.73 875 715374 151754 89760444
Injection site bruising 50.13 9.73 633 715616 51674 89860524
Wrist fracture 49.84 9.73 250 715999 15374 89896824
Atypical femur fracture 49.81 9.73 137 716112 6284 89905914
Suspected suicide 49.65 9.73 8 716241 9560 89902638
Cytomegalovirus infection reactivation 49.58 9.73 3 716246 7797 89904401
Aggression 49.50 9.73 84 716165 26584 89885614
Malaise 49.48 9.73 5322 710927 580664 89331534
Flatulence 49.21 9.73 522 715727 40845 89871353
Anuria 49.05 9.73 28 716221 14790 89897408
Bone density abnormal 48.99 9.73 104 716145 4036 89908162
Nephrolithiasis 48.76 9.73 598 715651 48487 89863711
Dizziness 48.52 9.73 5343 710906 583941 89328257
Frequent bowel movements 48.34 9.73 674 715575 56261 89855937
Lower limb fracture 47.92 9.73 941 715308 84072 89828126
Transaminases increased 47.92 9.73 143 716106 37049 89875149
Abortion induced 47.89 9.73 17 716232 11871 89900327
Alanine aminotransferase increased 47.72 9.73 653 715596 117685 89794513
Haematemesis 47.67 9.73 124 716125 33602 89878596
Stress 47.60 9.73 906 715343 80489 89831709
Swelling 47.53 9.73 2768 713481 416290 89495908
Injection site erythema 47.30 9.73 1065 715184 97437 89814761
Hot flush 47.23 9.73 696 715553 58792 89853406
Illness 47.12 9.73 910 715339 81059 89831139
Blood lactate dehydrogenase increased 46.93 9.73 83 716166 25849 89886349
Schizophrenia 46.82 9.73 30 716219 14884 89897314
Multiple-drug resistance 46.53 9.73 4 716245 7772 89904426
Osteoarthritis 46.52 9.73 1941 714308 193789 89718409
Macular degeneration 46.05 9.73 481 715768 37489 89874709
Peripheral swelling 45.74 9.73 3825 712424 409281 89502917
Hypervitaminosis D 45.61 9.73 20 716229 79 89912119
Sneezing 45.46 9.73 397 715852 29472 89882726
Erythema multiforme 45.25 9.73 20 716229 12226 89899972
Surgery 45.08 9.73 548 715701 44339 89867859
Hypomania 44.93 9.73 8 716241 8889 89903309
Dry eye 44.91 9.73 675 715574 57256 89854942
Labelled drug-drug interaction medication error 44.87 9.73 30 716219 14552 89897646
Inappropriate antidiuretic hormone secretion 44.57 9.73 53 716196 19452 89892746
Stress cardiomyopathy 44.54 9.73 25 716224 13330 89898868
No adverse event 44.53 9.73 334 715915 67648 89844550
Coagulopathy 44.49 9.73 72 716177 23217 89888981
Brain oedema 44.45 9.73 43 716206 17342 89894856
Skin exfoliation 44.30 9.73 769 715480 67144 89845054
Renal impairment 44.23 9.73 577 715672 104844 89807354
Hyperbilirubinaemia 43.80 9.73 28 716221 13908 89898290
Synovitis 43.78 9.73 2144 714105 327608 89584590
Hyperglycaemia 43.39 9.73 231 716018 50739 89861459
Premature labour 43.25 9.73 26 716223 13350 89898848
Hypertensive crisis 43.18 9.73 46 716203 17738 89894460
Sinus congestion 43.04 9.73 367 715882 27057 89885141
Syncope 43.02 9.73 763 715486 131900 89780298
Cystitis 42.99 9.73 754 715495 65964 89846234
Gamma-glutamyltransferase increased 42.63 9.73 155 716094 37797 89874401
Dyspepsia 42.42 9.73 1944 714305 196216 89715982
Foot fracture 42.26 9.73 357 715892 26249 89885949
Blood pressure abnormal 42.17 9.73 283 715966 19362 89892836
Neck pain 41.95 9.73 1189 715060 112774 89799424
Hypersensitivity 41.74 9.73 3061 713188 451616 89460582
Pruritus 41.70 9.73 4889 711360 536636 89375562
Respiratory disorder 41.58 9.73 732 715517 64084 89848114
Adrenal insufficiency 41.53 9.73 111 716138 29810 89882388
Blood creatine phosphokinase increased 40.88 9.73 135 716114 33888 89878310
Pulmonary embolism 40.66 9.73 758 715491 130062 89782136
Blood pressure increased 40.55 9.73 1927 714322 195290 89716908
Bone loss 40.49 9.73 87 716162 3405 89908793
Fibromyalgia 40.22 9.73 2005 714244 204264 89707934
Cerebral haemorrhage 40.11 9.73 139 716110 34383 89877815
Pre-existing condition improved 40.00 9.73 161 716088 9008 89903190
Bronchitis 39.93 9.73 1532 714717 151395 89760803
Glaucoma 39.86 9.73 291 715958 20464 89891734
Abdominal distension 39.67 9.73 1331 714918 129270 89782928
Micturition urgency 39.62 9.73 185 716064 11048 89901150
Inappropriate schedule of product administration 39.14 9.73 1502 714747 148431 89763767
Myocardial infarction 39.14 9.73 595 715654 105377 89806821
Neurologic neglect syndrome 39.12 9.73 156 716093 8691 89903507
Tubulointerstitial nephritis 39.11 9.73 89 716160 25254 89886944
Aspartate aminotransferase increased 39.04 9.73 575 715674 102362 89809836
Seasonal allergy 38.98 9.73 313 715936 22670 89889528
Bone density decreased 38.52 9.73 252 715997 17093 89895105
Drug dependence 38.33 9.73 112 716137 29215 89882983
Upper limb fracture 38.32 9.73 297 715952 21281 89890917
Bone lesion 38.25 9.73 125 716124 6312 89905886
Post transplant lymphoproliferative disorder 37.94 9.73 5 716244 6944 89905254
Thoracic vertebral fracture 37.80 9.73 112 716137 5362 89906836
Pathological fracture 37.75 9.73 164 716085 9496 89902702
Carotid artery thrombosis 37.57 9.73 157 716092 8935 89903263
Red blood cell count decreased 37.46 9.73 544 715705 45807 89866391
Osteoporosis 37.46 9.73 1014 715235 95517 89816681
Balance disorder 37.46 9.73 1019 715230 96061 89816137
Acute myeloid leukaemia 37.41 9.73 66 716183 20574 89891624
Stress fracture 37.40 9.73 151 716098 8460 89903738
Palmar-plantar erythrodysaesthesia syndrome 37.37 9.73 106 716143 27917 89884281
Hair texture abnormal 37.36 9.73 101 716148 4586 89907612
Chills 37.07 9.73 1333 714916 130648 89781550
Transplant rejection 36.96 9.73 28 716221 12730 89899468
Femur fracture 36.91 9.73 540 715709 45542 89866656
Parkinsonism 36.89 9.73 34 716215 14031 89898167
Oxygen saturation decreased 36.84 9.73 612 715637 106871 89805327
Blood pressure diastolic abnormal 36.55 9.73 63 716186 19818 89892380
Eosinophilia 36.55 9.73 110 716139 28423 89883775
Epstein-Barr virus infection 36.51 9.73 18 716231 10326 89901872
Hyperthermia 36.46 9.73 18 716231 10317 89901881
Subarachnoid haemorrhage 36.46 9.73 53 716196 17851 89894347
Cyanosis 36.37 9.73 61 716188 19394 89892804
JC polyomavirus test positive 36.30 9.73 57 716192 1745 89910453
Body temperature increased 36.24 9.73 525 715724 44185 89868013
Skin discolouration 36.17 9.73 521 715728 43794 89868404
Aplastic anaemia 36.09 9.73 31 716218 13238 89898960
Venoocclusive liver disease 36.09 9.73 3 716246 5990 89906208
Coronary artery disease 36.02 9.73 140 716109 33483 89878715
Arthritis 35.93 9.73 1642 714607 165673 89746525
Miosis 35.82 9.73 15 716234 9469 89902729
Sedation complication 35.65 9.73 49 716200 16895 89895303
Vasculitis 35.58 9.73 79 716170 22614 89889584
Migraine 35.54 9.73 1843 714406 188549 89723649
Chest pain 35.41 9.73 2960 713289 316685 89595513
Pain 35.10 9.73 8625 707624 987716 88924482
Hypoxia 35.06 9.73 384 715865 72015 89840183
Contusion 34.98 9.73 2369 713880 248847 89663351
Caesarean section 34.96 9.73 58 716191 18519 89893679
Adjustment disorder 34.89 9.73 160 716089 9482 89902716
Injection site mass 34.87 9.73 296 715953 21794 89890404
Dermatitis bullous 34.86 9.73 19 716230 10297 89901901
Ejection fraction abnormal 34.75 9.73 67 716182 2424 89909774
Blood parathyroid hormone increased 34.67 9.73 81 716168 3356 89908842
Blood 25-hydroxycholecalciferol increased 34.64 9.73 9 716240 0 89912198
Enterocolitis 34.47 9.73 20 716229 10470 89901728
Left ventricular dysfunction 34.45 9.73 39 716210 14630 89897568
Nicotine dependence 34.41 9.73 42 716207 1008 89911190
Immunodeficiency 34.05 9.73 201 716048 43033 89869165
Respiratory acidosis 33.77 9.73 11 716238 8108 89904090
Laboratory test abnormal 33.74 9.73 491 715758 41363 89870835
Pancreatitis acute 33.59 9.73 135 716114 31980 89880218
Central nervous system lesion 33.45 9.73 181 716068 11465 89900733
Respiratory distress 33.43 9.73 176 716073 38770 89873428
Bronchospasm 33.38 9.73 71 716178 20638 89891560
Bronchial neoplasm 33.25 9.73 30 716219 500 89911698
Deep vein thrombosis postoperative 33.18 9.73 763 715486 70046 89842152
Tooth disorder 33.18 9.73 384 715865 30706 89881492
Vision blurred 32.47 9.73 1120 715129 109173 89803025
Eye pain 32.45 9.73 510 715739 43658 89868540
Tooth extraction 32.44 9.73 178 716071 11335 89900863
Mean cell haemoglobin concentration abnormal 32.38 9.73 18 716231 130 89912068
Pneumonitis 32.37 9.73 210 716039 43960 89868238
Electrocardiogram QRS complex prolonged 32.29 9.73 9 716240 7339 89904859
Hypercalcaemia 32.23 9.73 413 715836 33827 89878371
Sensory loss 32.22 9.73 249 716000 17826 89894372
Acute graft versus host disease 32.21 9.73 3 716246 5465 89906733
Disorientation 32.20 9.73 210 716039 43904 89868294
Confusional state 32.14 9.73 2621 713628 383584 89528614
Hepatic enzyme increased 32.06 9.73 2435 713814 358301 89553897
Sputum purulent 31.84 9.73 46 716203 1306 89910892
Drug use disorder 31.83 9.73 13 716236 8330 89903868
Akathisia 31.68 9.73 25 716224 11134 89901064
Sinus tachycardia 31.66 9.73 117 716132 28396 89883802
Injection site pruritus 31.39 9.73 599 715650 53235 89858963
Vitamin D increased 31.26 9.73 38 716211 908 89911290
Injection site reaction 31.24 9.73 951 715298 91129 89821069
Haemodialysis 31.21 9.73 15 716234 8732 89903466
Palpitations 31.15 9.73 1350 714899 135378 89776820
Exposure to toxic agent 31.07 9.73 12 716237 7955 89904243
Hallucination, visual 31.05 9.73 87 716162 23005 89889193
Lumbar vertebral fracture 30.99 9.73 129 716120 7329 89904869
Metastases to central nervous system 30.98 9.73 57 716192 17485 89894713
Diverticulitis 30.68 9.73 515 715734 44672 89867526
Unintended pregnancy 30.63 9.73 11 716238 7626 89904572
Ankle fracture 30.61 9.73 270 715979 20100 89892098
Autoimmune disorder 30.59 9.73 809 715440 75935 89836263
Urine leukocyte esterase positive 30.57 9.73 75 716174 3207 89908991
Hypervitaminosis 30.52 9.73 13 716236 47 89912151
Cystic fibrosis 30.49 9.73 84 716165 3857 89908341
Atrioventricular block complete 30.44 9.73 20 716229 9791 89902407
Tonsillar ulcer 30.43 9.73 23 716226 295 89911903
Cytomegalovirus viraemia 30.30 9.73 11 716238 7575 89904623
Arterial occlusive disease 30.23 9.73 185 716064 12261 89899937
Wound 30.20 9.73 2025 714224 300955 89611243
Haemodynamic instability 30.05 9.73 29 716220 11710 89900488
Hernia 29.95 9.73 204 716045 14027 89898171
Back disorder 29.82 9.73 322 715927 25309 89886889
Rib fracture 29.79 9.73 330 715919 26105 89886093
Intramedullary rod insertion 29.78 9.73 58 716191 2114 89910084
Peritonitis 29.76 9.73 70 716179 19635 89892563
Bowel movement irregularity 29.72 9.73 116 716133 6398 89905800
Dysgeusia 29.69 9.73 582 715667 51978 89860220
Therapy partial responder 29.68 9.73 83 716166 21960 89890238
Dystonia 29.39 9.73 55 716194 16764 89895434
Shock haemorrhagic 29.36 9.73 32 716217 12213 89899985
Urticaria 29.29 9.73 2861 713388 309873 89602325
Nervousness 29.25 9.73 404 715845 33652 89878546
Tumour lysis syndrome 29.20 9.73 27 716222 11125 89901073
Polyneuropathy 28.98 9.73 69 716180 19272 89892926
Musculoskeletal discomfort 28.89 9.73 273 715976 20718 89891480
Enterococcal infection 28.85 9.73 22 716227 9969 89902229
Pathogen resistance 28.83 9.73 14 716235 8101 89904097
Oropharyngeal pain 28.67 9.73 1148 715101 114039 89798159
Meralgia paraesthetica 28.63 9.73 28 716221 519 89911679
Bronchial wall thickening 28.13 9.73 56 716193 2075 89910123
Myocarditis 27.98 9.73 41 716208 13765 89898433
Bronchial haemorrhage 27.97 9.73 30 716219 623 89911575
Encephalitis 27.93 9.73 28 716221 11106 89901092
Pallor 27.89 9.73 157 716092 34008 89878190
Hepatitis acute 27.75 9.73 27 716222 10860 89901338
Hospitalisation 27.68 9.73 1258 714991 126842 89785356
Abortion spontaneous 27.68 9.73 283 715966 53773 89858425
Essential hypertension 27.64 9.73 111 716138 6204 89905994
Musculoskeletal stiffness 27.51 9.73 2711 713538 293821 89618377
Device difficult to use 27.49 9.73 61 716188 17464 89894734
Maternal drugs affecting foetus 27.46 9.73 4 716245 5151 89907047
Catatonia 27.41 9.73 7 716242 6049 89906149
Pericarditis 27.35 9.73 1803 714446 268348 89643850
Gastrointestinal toxicity 27.14 9.73 21 716228 9446 89902752
Blood cholesterol increased 26.94 9.73 1950 714299 206062 89706136
Injection site urticaria 26.69 9.73 238 716011 17773 89894425
Electrolyte imbalance 26.65 9.73 97 716152 23648 89888550
Toxic encephalopathy 26.63 9.73 18 716231 8681 89903517
Product prescribing error 26.57 9.73 135 716114 30010 89882188
Haematoma 26.46 9.73 190 716059 38858 89873340
Coma scale abnormal 26.45 9.73 6 716243 5620 89906578
Ileus 26.44 9.73 57 716192 16489 89895709
Neuralgia 26.37 9.73 372 715877 31128 89881070
Cardiac disorder 26.08 9.73 611 715638 56261 89855937
Therapy cessation 26.01 9.73 418 715831 35943 89876255
Swollen tongue 25.90 9.73 235 716014 45721 89866477
Myelodysplastic syndrome 25.77 9.73 82 716167 20821 89891377
Endometrial ablation 25.69 9.73 36 716213 993 89911205
Pulmonary oedema 25.59 9.73 341 715908 61739 89850459
Multiple allergies 25.54 9.73 206 716043 14940 89897258
Urine abnormality 25.53 9.73 125 716124 7612 89904586
Paradoxical drug reaction 25.46 9.73 7 716242 5759 89906439
Arthropathy 25.44 9.73 2520 713729 363722 89548476
Hypothermia 25.44 9.73 53 716196 15522 89896676
Tachypnoea 25.30 9.73 85 716164 21224 89890974
Diabetic ketoacidosis 25.28 9.73 103 716146 24304 89887894
Unintentional medical device removal 25.17 9.73 12 716237 7018 89905180
Taste disorder 25.17 9.73 651 715598 60895 89851303
Peroneal nerve palsy 25.13 9.73 101 716148 5647 89906551
Dry throat 25.13 9.73 127 716122 7833 89904365
Depressed mood 25.05 9.73 546 715703 49676 89862522
Gastrointestinal pain 25.00 9.73 163 716086 11043 89901155
Intervertebral disc degeneration 24.95 9.73 227 716022 17047 89895151
Motor dysfunction 24.94 9.73 247 716002 18983 89893215
Nephrectomy 24.89 9.73 51 716198 1930 89910268
Weight fluctuation 24.81 9.73 252 715997 19497 89892701
Head discomfort 24.81 9.73 217 716032 16116 89896082
Myopathy 24.70 9.73 43 716206 13475 89898723
Cutaneous vasculitis 24.67 9.73 13 716236 7180 89905018
Immune system disorder 24.66 9.73 170 716079 11735 89900463
Drug eruption 24.62 9.73 171 716078 35236 89876962
Nephropathy toxic 24.45 9.73 39 716210 12649 89899549
Toothache 24.36 9.73 276 715973 21954 89890244
Medication error 24.32 9.73 497 715752 84155 89828043
Sinus bradycardia 24.21 9.73 62 716187 16890 89895308
Hepatic enzyme abnormal 24.18 9.73 122 716127 7520 89904678
Hypoacusis 24.17 9.73 331 715918 27519 89884679
Nasal turbinate hypertrophy 24.16 9.73 33 716216 888 89911310
Aspergillus infection 24.11 9.73 30 716219 10793 89901405
Acute coronary syndrome 24.05 9.73 30 716219 10783 89901415
COVID-19 immunisation 23.97 9.73 47 716202 1722 89910476
Orthostatic hypotension 23.96 9.73 213 716036 41614 89870584
Pneumonia 23.93 9.73 5540 710709 632519 89279679
Hallucination, auditory 23.93 9.73 57 716192 15918 89896280
Chronic disease 23.85 9.73 17 716232 198 89912000
Thyroid disorder 23.83 9.73 230 716019 17555 89894643
Breath sounds abnormal 23.67 9.73 205 716044 15181 89897017
Haematuria 23.67 9.73 170 716079 34767 89877431
Skin toxicity 23.62 9.73 12 716237 6767 89905431
Paraesthesia oral 23.42 9.73 366 715883 31293 89880905
Mean cell haemoglobin increased 23.36 9.73 76 716173 3829 89908369
Stillbirth 23.33 9.73 15 716234 7428 89904770
Lymphocyte count decreased 23.26 9.73 398 715851 34652 89877546
Bronchial disorder 23.25 9.73 43 716206 1507 89910691
Spinal operation 23.17 9.73 149 716100 10047 89902151
Oliguria 23.09 9.73 30 716219 10594 89901604
Decreased interest 23.04 9.73 82 716167 4325 89907873
Blood cholesterol abnormal 22.76 9.73 62 716187 2828 89909370
Post procedural hypothyroidism 22.70 9.73 21 716228 362 89911836
Intervertebral disc protrusion 22.70 9.73 321 715928 26875 89885323
Hyperlactacidaemia 22.52 9.73 3 716246 4133 89908065
Eating disorder 22.50 9.73 329 715920 27744 89884454
Reversible cerebral vasoconstriction syndrome 22.48 9.73 3 716246 4127 89908071
Urine odour abnormal 22.47 9.73 115 716134 7129 89905069
Anti-cyclic citrullinated peptide antibody positive 22.42 9.73 1587 714662 234846 89677352
Gait spastic 22.37 9.73 19 716230 291 89911907
Drug-induced liver injury 22.31 9.73 543 715706 89775 89822423
Productive cough 22.29 9.73 781 715468 76282 89835916
Pancreatic neuroendocrine tumour 22.22 9.73 26 716223 596 89911602
Pulmonary mass 22.20 9.73 335 715914 28437 89883761
Graft versus host disease 22.18 9.73 19 716230 8125 89904073
Device use error 22.03 9.73 15 716234 7206 89904992
Creatinine renal clearance decreased 22.02 9.73 76 716173 18823 89893375
Galactorrhoea 21.93 9.73 5 716244 4667 89907531
Therapeutic response unexpected 21.92 9.73 267 715982 21613 89890585
Thrombosis 21.85 9.73 745 715504 72506 89839692
Appetite disorder 21.71 9.73 135 716114 8998 89903200
Genital haemorrhage 21.70 9.73 22 716227 8680 89903518
Bradyphrenia 21.68 9.73 17 716232 7595 89904603
Acute myocardial infarction 21.64 9.73 174 716075 34716 89877482
Aplasia 21.48 9.73 3 716246 3988 89908210
Vitamin B12 decreased 21.40 9.73 91 716158 5219 89906979
Therapeutic product effect decreased 21.39 9.73 1895 714354 275676 89636522
Abnormal faeces 21.37 9.73 107 716142 6575 89905623
Oral pain 21.28 9.73 370 715879 32313 89879885
Rash erythematous 21.24 9.73 374 715875 64730 89847468
Discomfort 21.12 9.73 1873 714376 272462 89639736
Pulmonary tuberculosis 21.10 9.73 6 716243 4828 89907370
Malabsorption 21.07 9.73 89 716160 5089 89907109
Rhinitis allergic 21 9.73 214 716035 16571 89895627
Foetal growth restriction 20.89 9.73 26 716223 9354 89902844
Ketoacidosis 20.89 9.73 9 716240 5586 89906612
Drug level increased 20.85 9.73 131 716118 27631 89884567
Haemolytic anaemia 20.66 9.73 38 716211 11659 89900539
Endometriosis 20.66 9.73 101 716148 6147 89906051
Hyperpyrexia 20.61 9.73 6 716243 4755 89907443
Metastases to liver 20.59 9.73 138 716111 28669 89883529
Calciphylaxis 20.46 9.73 66 716183 3310 89908888
Immune effector cell-associated neurotoxicity syndrome 20.42 9.73 10 716239 5758 89906440
Faeces soft 20.41 9.73 115 716134 7396 89904802
Prescribed underdose 20.40 9.73 755 715494 74264 89837934
Cystitis haemorrhagic 20.38 9.73 9 716240 5504 89906694
Arrhythmia 20.31 9.73 225 716024 42107 89870091
Secondary progressive multiple sclerosis 20.25 9.73 41 716208 1538 89910660
Sinus headache 20.22 9.73 103 716146 6373 89905825
Exercise tolerance decreased 20.12 9.73 115 716134 7436 89904762
Road traffic accident 20.11 9.73 1042 715207 106584 89805614
Sciatica 20.06 9.73 987 715262 100395 89811803
Cardiac failure congestive 20.06 9.73 610 715639 98084 89814114
Neutrophil count decreased 19.95 9.73 422 715827 71110 89841088
Hyperprolactinaemia 19.88 9.73 9 716240 5424 89906774
Eye irritation 19.79 9.73 378 715871 33600 89878598
Personality disorder 19.78 9.73 167 716082 12277 89899921
Nephritic syndrome 19.77 9.73 20 716229 387 89911811
Blood iron decreased 19.69 9.73 223 716026 17736 89894462
Adenovirus infection 19.69 9.73 6 716243 4616 89907582
Open reduction of fracture 19.69 9.73 34 716215 1128 89911070
Blood pressure systolic abnormal 19.67 9.73 83 716166 19395 89892803
Visual impairment 19.62 9.73 1255 714994 131110 89781088
Leukoencephalopathy 19.58 9.73 7 716242 4866 89907332
Product complaint 19.57 9.73 49 716200 13451 89898747
Cardiovascular disorder 19.53 9.73 49 716200 13443 89898755
Gangrene 19.52 9.73 171 716078 12705 89899493
Pain in jaw 19.46 9.73 507 715742 47478 89864720
Erysipelas 19.23 9.73 26 716223 9026 89903172
Spinal compression fracture 19.22 9.73 194 716055 14984 89897214
Peripheral sensory neuropathy 19.21 9.73 27 716222 9223 89902975
Crying 19.17 9.73 297 715952 25348 89886850
Lymphoproliferative disorder 19.15 9.73 5 716244 4257 89907941
Restless legs syndrome 19.07 9.73 266 715983 22204 89889994
Angina unstable 19.05 9.73 17 716232 7126 89905072
Psychomotor retardation 19.04 9.73 7 716242 4782 89907416
Fracture displacement 19.03 9.73 35 716214 1221 89910977
Pulmonary toxicity 19.03 9.73 39 716210 11492 89900706
Abnormal behaviour 19.01 9.73 103 716146 22525 89889673
Osteomalacia 18.99 9.73 29 716220 866 89911332
Sinus rhythm 18.99 9.73 37 716212 1349 89910849
Breast cancer 18.98 9.73 558 715691 53203 89858995
Transplant dysfunction 18.94 9.73 9 716240 5273 89906925
Hypernatraemia 18.91 9.73 28 716221 9359 89902839
Metastases to lymph nodes 18.90 9.73 40 716209 11649 89900549
Short-bowel syndrome 18.86 9.73 25 716224 653 89911545
Injection site rash 18.86 9.73 282 715967 23891 89888307
Hallucination 18.72 9.73 388 715861 65571 89846627
Tuberculosis 18.62 9.73 45 716204 12504 89899694
Myocardial ischaemia 18.61 9.73 52 716197 13762 89898436
Isosthenuria 18.61 9.73 12 716237 117 89912081
Lacrimation increased 18.58 9.73 309 715940 26753 89885445
Hypogammaglobulinaemia 18.57 9.73 35 716214 10639 89901559
Rash pruritic 18.55 9.73 811 715438 81403 89830795
Rotator cuff syndrome 18.52 9.73 200 716049 15719 89896479
Infection 18.51 9.73 2543 713706 359551 89552647
Metabolic disorder 18.50 9.73 19 716230 7451 89904747
Injection site swelling 18.46 9.73 611 715638 59228 89852970
Drug withdrawal syndrome 18.39 9.73 142 716107 28581 89883617
Hypercalciuria 18.36 9.73 19 716230 378 89911820
Red blood cell sedimentation rate 18.19 9.73 7 716242 4651 89907547
Oligohydramnios 18.19 9.73 18 716231 7183 89905015
Anosognosia 18.15 9.73 3 716246 3519 89908679
Foreign body in reproductive tract 18.09 9.73 33 716216 1144 89911054
Palmoplantar keratoderma 18.05 9.73 3 716246 3504 89908694
Arthropod bite 18.05 9.73 125 716124 8642 89903556
Onychoclasis 17.98 9.73 110 716139 7289 89904909
Loss of personal independence in daily activities 17.97 9.73 1278 714971 134827 89777371
Acidosis 17.86 9.73 47 716202 12689 89899509
Azotaemia 17.85 9.73 10 716239 5338 89906860
Rhonchi 17.85 9.73 58 716191 2920 89909278
Intraductal proliferative breast lesion 17.84 9.73 64 716185 3389 89908809
Wrong patient received product 17.84 9.73 3 716246 3474 89908724
Tibia fracture 17.75 9.73 95 716154 5992 89906206
Urine analysis abnormal 17.69 9.73 85 716164 5136 89907062
Muscle tightness 17.62 9.73 173 716076 13266 89898932
Laryngeal oedema 17.62 9.73 17 716232 6864 89905334
Pregnancy with contraceptive device 17.61 9.73 9 716240 5057 89907141
Dermatitis exfoliative 17.57 9.73 11 716238 5525 89906673
Degenerative bone disease 17.48 9.73 16 716233 272 89911926
Product monitoring error 17.47 9.73 7 716242 4537 89907661
Low birth weight baby 17.40 9.73 30 716219 9437 89902761
Therapeutic reaction time decreased 17.39 9.73 66 716183 3592 89908606
Ingrowing nail 17.33 9.73 56 716193 2811 89909387
Wound infection 17.29 9.73 1017 715232 105385 89806813
Somnolence 17.21 9.73 1420 714829 207664 89704534
Lower respiratory tract infection viral 17.21 9.73 29 716220 943 89911255
Blood parathyroid hormone abnormal 17.18 9.73 15 716234 239 89911959
Pemphigoid 17.15 9.73 28 716221 8998 89903200
Secondary immunodeficiency 17.13 9.73 46 716203 2080 89910118
Hypomagnesaemia 17.13 9.73 189 716060 35399 89876799
Lupus vulgaris 17.10 9.73 472 715777 44587 89867611
Sudden death 17.09 9.73 38 716211 10871 89901327
Mouth ulceration 17.05 9.73 218 716031 39756 89872442
Increased tendency to bruise 17.05 9.73 156 716093 11734 89900464
Vitamin D abnormal 16.99 9.73 13 716236 170 89912028
Tooth fracture 16.91 9.73 163 716086 12437 89899761
Schizoaffective disorder 16.87 9.73 83 716166 5064 89907134
Limb injury 16.83 9.73 346 715903 31162 89881036
Renal disorder 16.83 9.73 405 715844 37454 89874744
Blood magnesium decreased 16.82 9.73 194 716055 15499 89896699
Tooth infection 16.80 9.73 238 716011 19932 89892266
Tachyarrhythmia 16.80 9.73 11 716238 5395 89906803
Urinary retention 16.79 9.73 204 716045 37540 89874658
Immunosuppressant drug level increased 16.74 9.73 8 716241 4672 89907526
Concomitant disease progression 16.70 9.73 47 716202 2185 89910013
Brain injury 16.66 9.73 22 716227 7716 89904482
Unresponsive to stimuli 16.59 9.73 207 716042 37914 89874284
Disseminated tuberculosis 16.59 9.73 3 716246 3296 89908902
Eye infection 16.55 9.73 179 716070 14075 89898123
Chronic graft versus host disease 16.54 9.73 6 716243 4133 89908065
Hypoalbuminaemia 16.52 9.73 67 716182 15830 89896368
Proteinuria 16.43 9.73 112 716137 23179 89889019
Cardiomyopathy 16.41 9.73 93 716156 20113 89892085
Pericardial effusion 16.41 9.73 199 716050 36634 89875564
Dental implantation 16.38 9.73 27 716222 862 89911336
Liver injury 16.33 9.73 1563 714686 169004 89743194
Pulmonary alveolar haemorrhage 16.33 9.73 14 716235 5984 89906214
Apnoea 16.26 9.73 31 716218 9383 89902815
Lymphocyte percentage decreased 16.19 9.73 58 716191 3069 89909129
Collagen-vascular disease 16.17 9.73 10 716239 90 89912108
Acute pulmonary oedema 16.16 9.73 32 716217 9548 89902650
Intentional dose omission 16.11 9.73 213 716036 17570 89894628
Ageusia 16.03 9.73 196 716053 15880 89896318
Hyperplastic cholecystopathy 16.00 9.73 12 716237 152 89912046
Ill-defined disorder 15.94 9.73 1251 714998 183640 89728558
Red blood cell count increased 15.92 9.73 64 716185 3579 89908619
Musculoskeletal pain 15.92 9.73 1566 714683 169685 89742513
Pulseless electrical activity 15.79 9.73 29 716220 8903 89903295
Immune-mediated enterocolitis 15.73 9.73 9 716240 4748 89907450
Type IIa hyperlipidaemia 15.71 9.73 16 716233 312 89911886
Snoring 15.64 9.73 81 716168 5045 89907153
Compression fracture 15.62 9.73 121 716128 8668 89903530
Cardiac failure chronic 15.59 9.73 13 716236 5633 89906565
Pneumatosis intestinalis 15.50 9.73 4 716245 3433 89908765
Substance abuse 15.49 9.73 12 716237 5394 89906804
Large intestine polyp 15.47 9.73 127 716122 9259 89902939
Parathyroid tumour benign 15.36 9.73 27 716222 909 89911289
Vestibular migraine 15.29 9.73 14 716235 238 89911960
Amnesia 15.22 9.73 1024 715225 107481 89804717
Leukocytosis 15.15 9.73 164 716085 30826 89881372
Feeling hot 15.13 9.73 758 715491 77250 89834948
Hysterectomy 15.12 9.73 149 716100 11435 89900763
Fibula fracture 15.10 9.73 70 716179 4167 89908031
Cervix neoplasm 15.10 9.73 13 716236 203 89911995
Pulmonary haemorrhage 15.09 9.73 25 716224 7988 89904210
Faecaloma 15.01 9.73 38 716211 10393 89901805
Affect lability 14.99 9.73 213 716036 17850 89894348
Upper gastrointestinal haemorrhage 14.99 9.73 113 716136 22863 89889335
Ileus paralytic 14.94 9.73 11 716238 5074 89907124
Rash 14.94 9.73 5865 710384 790235 89121963
Neuropathy peripheral 14.92 9.73 1267 714982 135703 89776495
Cell death 14.89 9.73 3 716246 3052 89909146
Hypersomnia 14.84 9.73 246 716003 21285 89890913
Musculoskeletal chest pain 14.80 9.73 267 715982 23483 89888715
Bladder disorder 14.78 9.73 140 716109 10632 89901566
Cholecystectomy 14.77 9.73 150 716099 11605 89900593
Congestive cardiomyopathy 14.75 9.73 22 716227 7332 89904866
Post procedural stroke 14.71 9.73 8 716241 55 89912143
Clostridium difficile infection 14.71 9.73 383 715866 35862 89876336
Viral infection 14.66 9.73 430 715819 40984 89871214
Mobility decreased 14.65 9.73 2227 714022 248507 89663691
Skin atrophy 14.60 9.73 84 716165 5445 89906753
Cataract operation 14.59 9.73 91 716158 6072 89906126
Low turnover osteopathy 14.53 9.73 69 716180 4149 89908049
Mucous stools 14.52 9.73 81 716168 5190 89907008
Nausea 14.50 9.73 9281 706968 1101035 88811163
Small for dates baby 14.49 9.73 11 716238 4996 89907202
Groin pain 14.47 9.73 154 716095 12059 89900139
Pseudomonal sepsis 14.43 9.73 8 716241 4294 89907904
Muscle strain 14.35 9.73 128 716121 9559 89902639
Dysstasia 14.35 9.73 278 715971 24774 89887424
Intervertebral discitis 14.32 9.73 9 716240 4511 89907687
Large intestine perforation 14.27 9.73 35 716214 9677 89902521
Intentional underdose 14.22 9.73 42 716207 2007 89910191
Systemic candida 14.22 9.73 11 716238 4948 89907250
Activated partial thromboplastin time prolonged 14.20 9.73 25 716224 7800 89904398
Eye swelling 14.19 9.73 318 715931 29068 89883130
Atypical fracture 14.18 9.73 26 716223 905 89911293
Methaemoglobinaemia 14.15 9.73 7 716242 4008 89908190
Paranasal cyst 14.12 9.73 24 716225 786 89911412
Drug screen positive 14.10 9.73 6 716243 3751 89908447
Abdominal discomfort 13.99 9.73 3453 712796 473875 89438323
Hypotonia 13.96 9.73 45 716204 11381 89900817
Cardiac failure acute 13.88 9.73 48 716201 11881 89900317
Hypertransaminasaemia 13.87 9.73 71 716178 15754 89896444
Therapeutic response shortened 13.83 9.73 256 715993 22623 89889575
Colitis microscopic 13.83 9.73 142 716107 11017 89901181
Uterine perforation 13.83 9.73 24 716225 7530 89904668
Nephrotic syndrome 13.73 9.73 23 716226 7316 89904882
Restlessness 13.72 9.73 199 716050 35521 89876677
Dyslipidaemia 13.69 9.73 131 716118 9976 89902222
Device dislocation 13.68 9.73 171 716078 31311 89880887
Pelvic fracture 13.67 9.73 182 716067 15037 89897161
C-telopeptide increased 13.65 9.73 7 716242 42 89912156
Bladder operation 13.64 9.73 27 716222 996 89911202
Breast pain 13.60 9.73 134 716115 10284 89901914
Duodenal ulcer 13.59 9.73 35 716214 9517 89902681
Hyperparathyroidism secondary 13.55 9.73 38 716211 1763 89910435
Graft versus host disease in gastrointestinal tract 13.54 9.73 9 716240 4379 89907819
Torus fracture 13.53 9.73 11 716238 158 89912040
Feeling cold 13.51 9.73 298 715951 27167 89885031
Hypovolaemic shock 13.49 9.73 22 716227 7072 89905126
Feeling jittery 13.47 9.73 183 716066 15188 89897010
Defaecation urgency 13.45 9.73 90 716159 6152 89906046
Polymyalgia rheumatica 13.39 9.73 76 716173 4901 89907297
Insurance issue 13.37 9.73 139 716110 10819 89901379
Back injury 13.36 9.73 472 715777 46150 89866048
Haemorrhage intracranial 13.30 9.73 68 716181 15094 89897104
Gastrointestinal stoma output increased 13.30 9.73 20 716229 589 89911609
Oophorectomy 13.28 9.73 22 716227 705 89911493
Hyperreflexia 13.27 9.73 20 716229 6637 89905561
Adrenocortical insufficiency acute 13.26 9.73 48 716201 2553 89909645
Hepatitis cholestatic 13.26 9.73 30 716219 8531 89903667
Retroperitoneal haematoma 13.26 9.73 5 716244 3363 89908835
Gastrointestinal perforation 13.21 9.73 9 716240 4323 89907875
Gallbladder operation 13.18 9.73 50 716199 2721 89909477
Eye disorder 13.10 9.73 296 715953 27094 89885104
Cardiac dysfunction 13.09 9.73 6 716243 3591 89908607
Helicobacter infection 13.07 9.73 1581 714668 225269 89686929
Product distribution issue 13.05 9.73 61 716188 3644 89908554
Tenosynovitis 12.97 9.73 65 716184 14502 89897696
Nocturia 12.95 9.73 131 716118 10124 89902074
Coordination abnormal 12.92 9.73 239 716010 21117 89891081
Staphylococcal sepsis 12.88 9.73 35 716214 9348 89902850
Colitis ischaemic 12.85 9.73 52 716197 12294 89899904
Coccydynia 12.78 9.73 41 716208 2050 89910148
Metastases to lung 12.78 9.73 74 716175 15917 89896281
Ventricular hypokinesia 12.76 9.73 14 716235 5327 89906871
Hospice care 12.76 9.73 125 716124 9579 89902619
Brain death 12.74 9.73 8 716241 4013 89908185
Right ventricular failure 12.74 9.73 94 716155 19111 89893087
Vascular malformation 12.74 9.73 22 716227 730 89911468
Gastric ulcer 12.73 9.73 147 716102 27301 89884897
Obstruction 12.69 9.73 63 716186 3858 89908340
Product use issue 12.68 9.73 2355 713894 327564 89584634
Blood potassium decreased 12.65 9.73 479 715770 47248 89864950
Heparin-induced thrombocytopenia 12.61 9.73 14 716235 5298 89906900
Pregnancy with implant contraceptive 12.60 9.73 7 716242 3754 89908444
Skin sensitisation 12.60 9.73 26 716223 989 89911209
Heart rate irregular 12.48 9.73 265 715984 24003 89888195
Hyperammonaemic encephalopathy 12.45 9.73 3 716246 2696 89909502
Hallucinations, mixed 12.42 9.73 17 716232 5872 89906326
Ventricular dysfunction 12.42 9.73 7 716242 3724 89908474
Increased appetite 12.41 9.73 145 716104 11620 89900578
Blood pressure systolic decreased 12.41 9.73 35 716214 9235 89902963
Radius fracture 12.40 9.73 64 716185 3980 89908218
Behaviour disorder 12.40 9.73 11 716238 4624 89907574
Walking aid user 12.39 9.73 368 715881 35138 89877060
Hepatitis toxic 12.39 9.73 7 716242 3718 89908480
Pneumonia fungal 12.28 9.73 23 716226 7008 89905190
Periprosthetic fracture 12.23 9.73 19 716230 576 89911622
Exposure via ingestion 12.23 9.73 3 716246 2664 89909534
Exposure via skin contact 12.23 9.73 134 716115 10571 89901627
Body temperature decreased 12.22 9.73 260 715989 23556 89888642
Heart rate abnormal 12.21 9.73 85 716164 5886 89906312
Hordeolum 12.16 9.73 73 716176 4805 89907393
Skin disorder 12.15 9.73 378 715871 36328 89875870
Head banging 12.13 9.73 16 716233 416 89911782
Stridor 12.09 9.73 12 716237 4781 89907417
Endodontic procedure 12.09 9.73 57 716192 3418 89908780
Cervical spinal stenosis 12.08 9.73 47 716202 2588 89909610
X-ray abnormal 12.07 9.73 456 715793 44968 89867230
Diffuse large B-cell lymphoma 12.05 9.73 32 716217 8613 89903585
Tonsillectomy 12.04 9.73 26 716223 1021 89911177
Ventricular septal defect 12.03 9.73 15 716234 5392 89906806
Purpura 12.01 9.73 68 716181 14710 89897488
Joint destruction 12.00 9.73 59 716190 13228 89898970
Menopause 11.94 9.73 55 716194 3266 89908932
Blood magnesium increased 11.93 9.73 56 716193 3352 89908846
Nephrogenic systemic fibrosis 11.92 9.73 9 716240 4099 89908099
Weight increased 11.85 9.73 3586 712663 414341 89497857
Needle fatigue 11.84 9.73 10 716239 152 89912046
Generalised oedema 11.82 9.73 95 716154 18958 89893240
Hypoproteinaemia 11.82 9.73 5 716244 3137 89909061
Paroxysmal extreme pain disorder 11.81 9.73 9 716240 117 89912081
Amenorrhoea 11.81 9.73 50 716199 11672 89900526
Trichorrhexis 11.81 9.73 32 716217 1455 89910743
Infusion site swelling 11.73 9.73 143 716106 11577 89900621
Clonus 11.73 9.73 17 716232 5733 89906465
Temperature intolerance 11.70 9.73 146 716103 11884 89900314
Refusal of treatment by patient 11.67 9.73 17 716232 5721 89906477
Head injury 11.64 9.73 326 715923 30862 89881336
Pneumonia cytomegaloviral 11.62 9.73 5 716244 3106 89909092
Klebsiella infection 11.60 9.73 42 716207 10255 89901943
Upper-airway cough syndrome 11.59 9.73 176 716073 14959 89897239
Nocardiosis 11.57 9.73 3 716246 2567 89909631
Neonatal respiratory distress syndrome 11.56 9.73 5 716244 3096 89909102
Muscle rigidity 11.55 9.73 66 716183 14243 89897955
Primary cough headache 11.55 9.73 3 716246 0 89912198
Rotavirus test positive 11.55 9.73 3 716246 0 89912198
Streptococcal sepsis 11.54 9.73 7 716242 3577 89908621
Tricuspid valve incompetence 11.53 9.73 81 716168 16650 89895548
Eyelid disorder 11.53 9.73 41 716208 2162 89910036
Calcification of muscle 11.51 9.73 11 716238 198 89912000
Nasal obstruction 11.50 9.73 46 716203 2566 89909632
Ankle arthroplasty 11.49 9.73 4 716245 2827 89909371
Therapeutic product effect incomplete 11.42 9.73 1723 714526 192173 89720025
Bone cyst 11.38 9.73 43 716206 2335 89909863
Blood 25-hydroxycholecalciferol decreased 11.38 9.73 8 716241 91 89912107
Vasoplegia syndrome 11.38 9.73 4 716245 2810 89909388
Gestational diabetes 11.37 9.73 44 716205 10538 89901660
Enzyme level decreased 11.35 9.73 5 716244 20 89912178
Flushing 11.35 9.73 829 715420 87662 89824536
Type V hyperlipidaemia 11.32 9.73 23 716226 865 89911333
Physiotherapy 11.31 9.73 8 716241 92 89912106
Subdural haematoma 11.27 9.73 81 716168 16564 89895634
Hemiplegia 11.27 9.73 185 716064 15975 89896223
Dyskinesia 11.25 9.73 212 716037 36322 89875876
Ischaemic hepatitis 11.24 9.73 4 716245 2789 89909409
Product dose omission in error 11.23 9.73 226 716023 20277 89891921
Periorbital oedema 11.22 9.73 23 716226 6776 89905422
Lupus nephritis 11.18 9.73 13 716236 4819 89907379
Procedural pain 11.17 9.73 344 715905 33016 89879182
Medical device site swelling 11.17 9.73 5 716244 21 89912177
Hepatitis B reactivation 11.16 9.73 9 716240 3965 89908233
Cardiac tamponade 11.15 9.73 17 716232 5615 89906583
Congestive hepatopathy 11.13 9.73 5 716244 3028 89909170
Disturbance in social behaviour 11.13 9.73 10 716239 4178 89908020
Pyelitis 11.12 9.73 12 716237 251 89911947
Full blood count increased 11.08 9.73 28 716221 1220 89910978
Mass excision 11.06 9.73 14 716235 349 89911849
Infusion site haemorrhage 11.05 9.73 77 716172 5334 89906864
Hyperparathyroidism primary 11.03 9.73 16 716233 456 89911742
Hepatomegaly 11.01 9.73 61 716188 13265 89898933
Atrial tachycardia 11.00 9.73 19 716230 5971 89906227
Cyst 10.97 9.73 188 716061 16373 89895825
Oculogyric crisis 10.96 9.73 3 716246 2476 89909722
Finger deformity 10.95 9.73 339 715910 32558 89879640
Type I hypersensitivity 10.95 9.73 10 716239 4145 89908053
Albumin globulin ratio increased 10.95 9.73 6 716243 42 89912156
Polyneuropathy idiopathic progressive 10.95 9.73 6 716243 42 89912156
Invasive ductal breast carcinoma 10.92 9.73 102 716147 7716 89904482
Disability assessment scale score increased 10.92 9.73 9 716240 3922 89908276
Adjustment disorder with depressed mood 10.91 9.73 551 715698 56202 89855996
Bladder discomfort 10.89 9.73 22 716227 824 89911374
Paronychia 10.89 9.73 30 716219 7976 89904222
Systemic infection 10.88 9.73 13 716236 4762 89907436
Ureteral stent insertion 10.88 9.73 13 716236 305 89911893
Sinus polyp degeneration 10.88 9.73 7 716242 68 89912130
Carcinoembryonic antigen increased 10.85 9.73 42 716207 2308 89909890
Vein discolouration 10.84 9.73 13 716236 306 89911892
Dissociation 10.84 9.73 23 716226 6692 89905506
Hypertonic bladder 10.80 9.73 65 716184 4283 89907915
Tympanosclerosis 10.79 9.73 7 716242 69 89912129
Pernicious anaemia 10.71 9.73 22 716227 834 89911364
Skin wrinkling 10.70 9.73 30 716219 1392 89910806
Intestinal perforation 10.68 9.73 65 716184 13816 89898382
Organising pneumonia 10.68 9.73 28 716221 7569 89904629
Ankle deformity 10.67 9.73 16 716233 470 89911728
Presbyacusis 10.65 9.73 50 716199 2992 89909206
Anorectal stenosis 10.64 9.73 5 716244 24 89912174
Ulcer haemorrhage 10.64 9.73 278 715971 26043 89886155
Hyperammonaemia 10.60 9.73 22 716227 6453 89905745
Cholelithiasis 10.55 9.73 325 715924 52181 89860017
Hepatic cirrhosis 10.55 9.73 606 715643 62647 89849551
Vaginal haematoma 10.53 9.73 9 716240 139 89912059
Bacterial vaginosis 10.52 9.73 33 716216 1630 89910568
Aphonia 10.52 9.73 146 716103 12173 89900025
Device related infection 10.49 9.73 142 716107 25644 89886554
Urine ketone body present 10.49 9.73 44 716205 2508 89909690
Cholecystitis chronic 10.47 9.73 41 716208 9785 89902413
Sarcoidosis 10.46 9.73 46 716203 10627 89901571
Exostosis 10.45 9.73 517 715732 52617 89859581
Blood lactic acid increased 10.43 9.73 35 716214 8743 89903455
Stupor 10.42 9.73 17 716232 5465 89906733
Drug specific antibody present 10.41 9.73 77 716172 5437 89906761
Pleural fibrosis 10.40 9.73 56 716193 3540 89908658
Rheumatic fever 10.39 9.73 1372 714877 151749 89760449
Pancreatic enlargement 10.38 9.73 7 716242 74 89912124
Hyperparathyroidism 10.37 9.73 53 716196 3284 89908914
Anaphylactoid reaction 10.36 9.73 12 716237 4456 89907742
Infusion site extravasation 10.33 9.73 126 716123 10202 89901996
Neutralising antibodies positive 10.30 9.73 13 716236 323 89911875
Thyroxine decreased 10.27 9.73 19 716230 666 89911532
Feeding disorder 10.26 9.73 195 716054 17317 89894881
Cytomegalovirus test positive 10.25 9.73 8 716241 3583 89908615
Blood creatinine abnormal 10.23 9.73 62 716187 4095 89908103
Nasal ulcer 10.22 9.73 45 716204 2621 89909577
Lip oedema 10.19 9.73 13 716236 4626 89907572
Tardive dyskinesia 10.18 9.73 48 716201 10882 89901316
Nerve compression 10.18 9.73 128 716121 10438 89901760
Bone marrow oedema 10.17 9.73 30 716219 1433 89910765
Intestinal ischaemia 10.16 9.73 36 716213 8847 89903351
Lung adenocarcinoma stage IV 10.15 9.73 15 716234 435 89911763
Thyroxine free increased 10.14 9.73 24 716225 1003 89911195
Laryngeal pain 10.12 9.73 12 716237 4410 89907788
Bacteraemia 10.12 9.73 120 716129 22180 89890018
Fungal infection 10.11 9.73 423 715826 42238 89869960
Internal fixation of fracture 10.10 9.73 21 716228 803 89911395
Hungry bone syndrome 10.07 9.73 9 716240 148 89912050
Nasal discharge discolouration 10.07 9.73 47 716202 2806 89909392
Brain herniation 10.05 9.73 11 716238 4189 89908009
Cervical vertebral fracture 10.02 9.73 52 716197 3241 89908957
Metabolic alkalosis 10.01 9.73 8 716241 3541 89908657
Stoma site discomfort 10.01 9.73 8 716241 112 89912086
Urethral pain 10.00 9.73 14 716235 386 89911812
Blepharospasm 9.99 9.73 535 715714 54910 89857288
Blood chloride increased 9.98 9.73 51 716198 3159 89909039
Congenital coronary artery malformation 9.98 9.73 9 716240 150 89912048
Infusion site pain 9.97 9.73 215 716034 19523 89892675
pH urine increased 9.97 9.73 14 716235 387 89911811
Hepatitis 9.95 9.73 457 715792 70282 89841916
Immune thrombocytopenia 9.95 9.73 63 716186 13263 89898935
Breast conserving surgery 9.91 9.73 26 716223 1159 89911039
Drug withdrawal syndrome neonatal 9.90 9.73 3 716246 2316 89909882
Acrochordon 9.84 9.73 30 716219 1459 89910739
Infusion site pruritus 9.82 9.73 89 716160 6676 89905522
Rash macular 9.81 9.73 311 715938 29969 89882229
Fracture nonunion 9.80 9.73 40 716209 2252 89909946
Chronic respiratory disease 9.80 9.73 12 716237 289 89911909
Parathyroid tumour 9.78 9.73 9 716240 154 89912044
Petit mal epilepsy 9.78 9.73 15 716234 4943 89907255
Tuberculin test positive 9.77 9.73 9 716240 3716 89908482
Pruritus genital 9.77 9.73 13 716236 4545 89907653
Brain abscess 9.77 9.73 5 716244 2807 89909391
Immunoglobulins increased 9.74 9.73 17 716232 569 89911629
Peripheral venous disease 9.73 9.73 780 715469 83141 89829057

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 513.83 10.47 227 203727 228909 42188472
Fatigue 477.27 10.47 3636 200318 432005 41985376
Drug interaction 458.67 10.47 364 203590 266635 42150746
Product dose omission issue 319.93 10.47 1524 202430 152841 42264540
Acute kidney injury 291.51 10.47 851 203103 366486 42050895
Drug abuse 264.16 10.47 86 203868 104685 42312696
Completed suicide 247.07 10.47 77 203877 96388 42320993
Multiple sclerosis relapse 199.34 10.47 291 203663 13973 42403408
Interstitial lung disease 175.11 10.47 78 203876 78384 42338997
Overdose 174.76 10.47 148 203806 105116 42312265
Hepatic function abnormal 160.14 10.47 27 203927 51540 42365841
Infective pulmonary exacerbation of cystic fibrosis 151.38 10.47 187 203767 7631 42409750
Multiple organ dysfunction syndrome 146.22 10.47 149 203805 96886 42320495
Myelosuppression 145.58 10.47 13 203941 40448 42376933
Thrombocytopenia 140.40 10.47 455 203499 189824 42227557
Febrile neutropenia 137.05 10.47 444 203510 185259 42232122
Cardiac failure 132.50 10.47 191 203763 106665 42310716
Fall 125.34 10.47 1691 202263 232829 42184552
Intentional overdose 124.85 10.47 45 203909 51411 42365970
Coma 124.66 10.47 50 203904 53504 42363877
Muscle spasms 119.09 10.47 762 203192 85282 42332099
Nasopharyngitis 118.19 10.47 747 203207 83249 42334132
Colitis ulcerative 113.11 10.47 328 203626 25847 42391534
Hepatic cytolysis 110.62 10.47 4 203950 26840 42390541
Septic shock 108.65 10.47 169 203785 91503 42325878
Obstructive airways disorder 107.70 10.47 311 203643 24448 42392933
Pain in extremity 107.62 10.47 1148 202806 149456 42267925
Full blood count abnormal 103.76 10.47 347 203607 29529 42387852
Vitamin D deficiency 100.41 10.47 156 203798 7917 42409464
Neutropenia 99.43 10.47 554 203400 198877 42218504
Suicide attempt 97.95 10.47 49 203905 46051 42371330
Weight decreased 96.88 10.47 1464 202490 206484 42210897
Drug reaction with eosinophilia and systemic symptoms 96.76 10.47 40 203914 42035 42375346
Hypotension 96.73 10.47 779 203175 256852 42160529
Conjunctivitis allergic 96.58 10.47 130 203824 5781 42411600
Rhabdomyolysis 96.16 10.47 140 203814 77879 42339502
Multiple sclerosis 96.15 10.47 148 203806 7450 42409931
Memory impairment 96.02 10.47 485 203469 49737 42367644
Sinusitis 95.60 10.47 464 203490 46828 42370553
Mite allergy 94.97 10.47 119 203835 4927 42412454
Mycotic allergy 94.71 10.47 117 203837 4774 42412607
Eosinophilic granulomatosis with polyangiitis 93.89 10.47 157 203797 8481 42408900
Arthralgia 92.94 10.47 1438 202516 203800 42213581
Pancytopenia 92.11 10.47 274 203680 117469 42299912
Hyperkalaemia 91.88 10.47 152 203802 80306 42337075
Spirometry abnormal 91.54 10.47 118 203836 5028 42412353
Dust allergy 91.32 10.47 120 203834 5212 42412169
Intentional dose omission 90.65 10.47 158 203796 8828 42408553
Cardio-respiratory arrest 90.64 10.47 88 203866 58548 42358833
Peripheral swelling 90.54 10.47 740 203214 89530 42327851
Balance disorder 90.30 10.47 459 203495 47186 42370195
Inappropriate schedule of product administration 89.73 10.47 774 203180 95128 42322253
Sleep disorder due to a general medical condition 89.63 10.47 233 203721 17220 42400161
Productive cough 88.95 10.47 484 203470 51083 42366298
Mucosal inflammation 88.75 10.47 64 203890 49310 42368071
Cholestasis 88.25 10.47 24 203930 32855 42384526
Plasma cell myeloma 87.14 10.47 454 203500 47124 42370257
Respiratory symptom 86.74 10.47 175 203779 10931 42406450
Drug resistance 86.46 10.47 28 203926 34220 42383161
Neuritis 85.60 10.47 126 203828 6094 42411287
Cardiac arrest 85.07 10.47 255 203699 109065 42308316
Cytomegalovirus infection 84.09 10.47 25 203929 32281 42385100
Nodule 81.15 10.47 183 203771 12351 42405030
Toxic epidermal necrolysis 80.88 10.47 15 203939 26735 42390646
Lactic acidosis 78.35 10.47 61 203893 45200 42372181
Muscle spasticity 78.20 10.47 127 203827 6695 42410686
Pulmonary vasculitis 77.81 10.47 121 203833 6145 42411236
Back pain 77.12 10.47 1026 202928 140750 42276631
Serotonin syndrome 77.06 10.47 15 203939 25830 42391551
Relapsing-remitting multiple sclerosis 76.90 10.47 61 203893 1434 42415947
Influenza 76.00 10.47 534 203420 61641 42355740
Diarrhoea 75.67 10.47 2804 201150 458045 41959336
Agranulocytosis 75.57 10.47 26 203928 30586 42386795
Asthma 75.47 10.47 534 203420 61780 42355601
Depressed level of consciousness 75.30 10.47 71 203883 47899 42369482
Pain 75.10 10.47 1614 202340 243234 42174147
Wheezing 73.83 10.47 482 203472 54299 42363082
Abdominal discomfort 71.76 10.47 610 203344 74645 42342736
Electrocardiogram QT prolonged 71.76 10.47 74 203880 47871 42369510
Bone giant cell tumour 71.74 10.47 20 203934 23 42417358
Loss of personal independence in daily activities 70.63 10.47 444 203510 49372 42368009
Frequent bowel movements 70.26 10.47 244 203710 21163 42396218
Respiratory failure 69.35 10.47 346 203608 127786 42289595
Leukopenia 69.06 10.47 160 203794 74586 42342795
Fractional exhaled nitric oxide increased 68.85 10.47 59 203895 1550 42415831
Rash maculo-papular 68.20 10.47 48 203906 37455 42379926
Shock 68.07 10.47 27 203927 29094 42388287
No adverse event 67.80 10.47 367 203587 38654 42378727
Cough 67.72 10.47 1213 202741 176890 42240491
Altered state of consciousness 66.98 10.47 28 203926 29231 42388150
Gait disturbance 66.23 10.47 739 203215 97261 42320120
Hepatocellular injury 66.01 10.47 16 203938 23662 42393719
Hot flush 65.07 10.47 245 203709 22106 42395275
Drug ineffective 63.57 10.47 2422 201532 627775 41789606
Hypoaesthesia 63.32 10.47 570 203384 70893 42346488
Neuroleptic malignant syndrome 62.89 10.47 13 203941 21459 42395922
Antineutrophil cytoplasmic antibody positive 62.36 10.47 90 203864 4275 42413106
Constipation 62.28 10.47 1107 202847 161184 42256197
Disseminated intravascular coagulation 61.31 10.47 21 203933 24773 42392608
Normochromic normocytic anaemia 60.88 10.47 134 203820 8897 42408484
Angioedema 60.85 10.47 68 203886 42409 42374972
Hyponatraemia 59.58 10.47 266 203688 101196 42316185
Gait spastic 58.94 10.47 51 203903 1358 42416023
Thrombosis 58.44 10.47 542 203412 67969 42349412
Pyrexia 58.41 10.47 1438 202516 392604 42024777
Renal failure 57.88 10.47 426 203528 143300 42274081
Cytokine release syndrome 56.73 10.47 78 203876 44449 42372932
General physical health deterioration 56.35 10.47 458 203496 150788 42266593
Full blood count decreased 56.27 10.47 221 203733 20339 42397042
Nasal polyps 55.89 10.47 80 203874 3771 42413610
Renal impairment 54.97 10.47 306 203648 109922 42307459
Feeling abnormal 54.05 10.47 541 203413 69245 42348136
Hypoglycaemia 53.79 10.47 130 203824 59724 42357657
Needle fatigue 52.97 10.47 45 203909 1168 42416213
Rhinorrhoea 52.53 10.47 295 203659 31499 42385882
Metabolic acidosis 52.04 10.47 106 203848 51752 42365629
Headache 51.91 10.47 1506 202448 237863 42179518
Hip fracture 51.76 10.47 162 203792 13310 42404071
Pneumocystis jirovecii pneumonia 51.66 10.47 28 203926 25153 42392228
Tachycardia 51.29 10.47 279 203675 100808 42316573
Neurological symptom 50.90 10.47 133 203821 9858 42407523
Toxic skin eruption 50.52 10.47 4 203950 13726 42403655
Circulatory collapse 50.39 10.47 25 203929 23611 42393770
Acute respiratory distress syndrome 50.33 10.47 42 203912 30066 42387315
Hepatic failure 50.31 10.47 65 203889 38035 42379346
Extrapyramidal disorder 50.05 10.47 9 203945 16403 42400978
Respiratory distress 49.61 10.47 77 203877 41743 42375638
Bone marrow failure 49.60 10.47 51 203903 33042 42384339
Disease progression 49.49 10.47 444 203510 143212 42274169
Cerebral infarction 49.07 10.47 46 203908 31123 42386258
Prostatic specific antigen increased 48.83 10.47 185 203769 16740 42400641
Hypervitaminosis D 48.55 10.47 15 203939 31 42417350
Plantar fasciitis 47.86 10.47 66 203888 3004 42414377
Adverse drug reaction 47.19 10.47 324 203630 37110 42380271
Mobility decreased 47.16 10.47 310 203644 34996 42382385
Pulmonary function test decreased 46.78 10.47 92 203862 5640 42411741
Therapeutic product effect incomplete 46.12 10.47 531 203423 70408 42346973
Anaphylactic reaction 45.82 10.47 84 203870 42659 42374722
Asthenia 45.78 10.47 1708 202246 279085 42138296
Anaemia 45.59 10.47 1008 202946 279270 42138111
Seasonal allergy 44.96 10.47 111 203843 7944 42409437
Arteriosclerosis 44.96 10.47 188 203766 17801 42399580
Insomnia 44.76 10.47 805 203149 117448 42299933
Melaena 44.40 10.47 73 203881 38673 42378708
Anaphylactic shock 44.23 10.47 29 203925 23488 42393893
Nocturia 44.12 10.47 143 203811 11969 42405412
Miosis 44.12 10.47 6 203948 13440 42403941
Haemophagocytic lymphohistiocytosis 44.08 10.47 16 203938 18206 42399175
Sedation 43.41 10.47 49 203905 30426 42386955
Heart rate decreased 43.02 10.47 311 203643 36221 42381160
Hypertonic bladder 42.98 10.47 55 203899 2326 42415055
Hospitalisation 42.92 10.47 544 203410 73786 42343595
Delirium 42.65 10.47 120 203834 52399 42364982
Sensation of foreign body 42.42 10.47 68 203886 3545 42413836
Stevens-Johnson syndrome 42.19 10.47 27 203927 22151 42395230
Hepatitis 42.14 10.47 41 203913 27259 42390122
Blood creatine phosphokinase increased 41.86 10.47 107 203847 48231 42369150
Weight increased 40.83 10.47 735 203219 107248 42310133
Total lung capacity abnormal 40.81 10.47 75 203879 4368 42413013
Hyperbilirubinaemia 40.81 10.47 24 203930 20611 42396770
Bronchopulmonary aspergillosis 40.74 10.47 21 203933 19408 42397973
Bradycardia 40.63 10.47 241 203713 85243 42332138
Dermatitis atopic 40.37 10.47 141 203813 12263 42405118
Hypokalaemia 40.33 10.47 191 203763 71530 42345851
Foetal exposure during pregnancy 39.99 10.47 106 203848 47205 42370176
Hepatotoxicity 39.78 10.47 37 203917 25130 42392251
Acute hepatic failure 39.62 10.47 16 203938 17057 42400324
Epilepsy 39.60 10.47 40 203914 26131 42391250
Poor venous access 39.50 10.47 99 203855 7153 42410228
Intentional self-injury 39.13 10.47 12 203942 15190 42402191
Vitamin D decreased 38.72 10.47 74 203880 4441 42412940
Influenza like illness 38.61 10.47 273 203681 31567 42385814
Tumour lysis syndrome 38.42 10.47 30 203924 22201 42395180
Blood lactate dehydrogenase increased 38.18 10.47 41 203913 26040 42391341
Haemodynamic instability 38.05 10.47 7 203947 12550 42404831
Sleep apnoea syndrome 38.05 10.47 204 203750 21404 42395977
Ascites 38.02 10.47 141 203813 56537 42360844
Venoocclusive liver disease 37.91 10.47 3 203951 10299 42407082
C-reactive protein increased 37.68 10.47 166 203788 63394 42353987
Central nervous system lesion 37.30 10.47 102 203852 7768 42409613
Status epilepticus 37.14 10.47 14 203940 15564 42401817
Cerebral haemorrhage 37.13 10.47 82 203872 38884 42378497
Blood pressure increased 36.86 10.47 689 203265 101239 42316142
Cystic fibrosis 36.36 10.47 47 203907 2008 42415373
Therapy partial responder 35.91 10.47 26 203928 19995 42397386
Nephropathy toxic 35.61 10.47 18 203936 16820 42400561
Musculoskeletal stiffness 35.60 10.47 428 203526 57337 42360044
Renal disorder 35.45 10.47 249 203705 28731 42388650
Jaundice 35.30 10.47 70 203884 34519 42382862
Aplastic anaemia 35.25 10.47 8 203946 12376 42405005
Bowel movement irregularity 34.65 10.47 61 203893 3435 42413946
Central nervous system mass 33.98 10.47 30 203924 821 42416560
Psoriasis 33.94 10.47 369 203585 48235 42369146
Spinal fracture 33.93 10.47 109 203845 9081 42408300
Sepsis 33.79 10.47 712 203242 198622 42218759
Bone density decreased 33.75 10.47 47 203907 2159 42415222
Myoglobin blood increased 33.63 10.47 62 203892 3620 42413761
Osteoporosis 33.59 10.47 151 203803 14755 42402626
Hepatitis cholestatic 33.16 10.47 4 203950 9820 42407561
Upper respiratory tract infection 33.16 10.47 328 203626 41845 42375536
Agitation 32.89 10.47 177 203777 64137 42353244
Drug ineffective for unapproved indication 32.86 10.47 112 203842 46051 42371330
Pollakiuria 32.77 10.47 202 203752 22303 42395078
Illness 32.75 10.47 218 203736 24712 42392669
Body height decreased 32.49 10.47 65 203889 4035 42413346
Thrombotic microangiopathy 32.48 10.47 15 203939 14767 42402614
Neutropenic sepsis 32.32 10.47 18 203936 15928 42401453
Cytomegalovirus infection reactivation 32.26 10.47 7 203947 11171 42406210
Hypercalcaemia 32.14 10.47 171 203783 17887 42399494
Bronchial wall thickening 32.09 10.47 36 203918 1324 42416057
Shock haemorrhagic 31.97 10.47 19 203935 16223 42401158
Wall motion score index abnormal 31.89 10.47 29 203925 826 42416555
Cataract 31.80 10.47 253 203701 30351 42387030
Dyspepsia 31.73 10.47 320 203634 41032 42376349
Product administration interrupted 31.58 10.47 72 203882 4894 42412487
Akathisia 31.29 10.47 6 203948 10445 42406936
Flatulence 31.29 10.47 217 203737 24935 42392446
Blood bilirubin increased 31.11 10.47 101 203853 42151 42375230
Labelled drug-drug interaction medication error 30.99 10.47 18 203936 15564 42401817
Exostosis 30.80 10.47 77 203877 5554 42411827
Vitamin D increased 30.79 10.47 13 203941 84 42417297
Airway remodelling 30.62 10.47 29 203925 871 42416510
Acne 30.58 10.47 138 203816 13506 42403875
Intervertebral disc degeneration 30.56 10.47 91 203863 7276 42410105
Atopy 30.50 10.47 30 203924 945 42416436
COVID-19 30.38 10.47 748 203206 115200 42302181
Premature baby 30.05 10.47 40 203914 23113 42394268
Neuropathy peripheral 30.04 10.47 668 203286 101185 42316196
Angina pectoris 29.90 10.47 71 203883 32825 42384556
Anuria 29.87 10.47 9 203945 11523 42405858
Viral infection 29.77 10.47 197 203757 22286 42395095
Polydactyly 29.69 10.47 33 203921 1201 42416180
Gamma-glutamyltransferase increased 29.65 10.47 70 203884 32427 42384954
Forced expiratory volume decreased 29.54 10.47 92 203862 7538 42409843
Pathogen resistance 29.54 10.47 9 203945 11441 42405940
Lacrimation increased 29.48 10.47 123 203831 11635 42405746
Respiratory arrest 29.46 10.47 57 203897 28367 42389014
Vomiting 29.33 10.47 1112 202842 288611 42128770
Dry skin 29.28 10.47 357 203597 47981 42369400
Aspergillus infection 29.15 10.47 20 203934 15817 42401564
Dysstasia 29.02 10.47 139 203815 13947 42403434
Red blood cell count decreased 28.99 10.47 261 203693 32454 42384927
Nephrolithiasis 28.73 10.47 286 203668 36544 42380837
Secretion discharge 28.59 10.47 91 203863 7544 42409837
Cardiogenic shock 28.52 10.47 82 203872 35558 42381823
Monoparesis 28.50 10.47 51 203903 2909 42414472
Localised infection 28.50 10.47 181 203773 20192 42397189
Dysphonia 28.37 10.47 233 203721 28217 42389164
Epstein-Barr virus infection 28.22 10.47 6 203948 9712 42407669
Ventricular fibrillation 28.20 10.47 64 203890 30059 42387322
Blood 25-hydroxycholecalciferol increased 27.95 10.47 7 203947 3 42417378
Torsade de pointes 27.81 10.47 4 203950 8590 42408791
Drug level increased 27.62 10.47 52 203902 26148 42391233
Exposure during pregnancy 27.61 10.47 4 203950 8544 42408837
Nasal congestion 27.50 10.47 238 203716 29263 42388118
Gastrooesophageal reflux disease 27.48 10.47 333 203621 44690 42372691
Laboratory test abnormal 27.27 10.47 196 203758 22782 42394599
Cardiac septal defect 27.21 10.47 28 203926 932 42416449
Dizziness 27.09 10.47 1455 202499 247799 42169582
Substance abuse 26.90 10.47 5 203949 8900 42408481
Haematemesis 26.80 10.47 66 203888 30133 42387248
Ventricular tachycardia 26.70 10.47 66 203888 30094 42387287
Neurotoxicity 26.69 10.47 45 203909 23606 42393775
Myocardial infarction 26.62 10.47 425 203529 123584 42293797
Aggression 26.38 10.47 115 203839 44048 42373333
Upper-airway cough syndrome 26.34 10.47 62 203892 4304 42413077
Liver function test abnormal 26.30 10.47 74 203880 32317 42385064
Pancreatitis acute 26.29 10.47 78 203876 33486 42383895
Anxiety 26.20 10.47 748 203206 117812 42299569
Injection site pain 26.08 10.47 405 203549 57393 42359988
Malignant neoplasm progression 25.85 10.47 364 203590 108036 42309345
Bronchial secretion retention 25.73 10.47 35 203919 1572 42415809
Atrioventricular septal defect 25.66 10.47 16 203938 252 42417129
Nephrocalcinosis 25.66 10.47 25 203929 778 42416603
Hernia 25.58 10.47 113 203841 10960 42406421
Blood pressure fluctuation 25.57 10.47 218 203736 26690 42390691
International normalised ratio increased 25.50 10.47 131 203823 48037 42369344
Dysgeusia 25.48 10.47 263 203691 33926 42383455
Treatment failure 25.47 10.47 185 203769 62439 42354942
Inappropriate antidiuretic hormone secretion 25.35 10.47 25 203929 16516 42400865
Acute graft versus host disease in skin 25.11 10.47 3 203951 7421 42409960
Blood parathyroid hormone increased 25.03 10.47 38 203916 1889 42415492
Oropharyngeal pain 24.90 10.47 312 203642 42198 42375183
Therapy interrupted 24.81 10.47 187 203767 22063 42395318
Myoclonus 24.79 10.47 27 203927 17038 42400343
Skin exfoliation 24.78 10.47 306 203648 41247 42376134
Cystitis haemorrhagic 24.70 10.47 3 203951 7326 42410055
Abdominal distension 24.58 10.47 481 203473 71254 42346127
Febrile bone marrow aplasia 24.52 10.47 9 203945 10172 42407209
Microangiopathy 24.49 10.47 35 203919 1647 42415734
Pulmonary haemorrhage 24.37 10.47 12 203942 11385 42405996
Arthritis 24.33 10.47 308 203646 41757 42375624
Ageusia 24.26 10.47 115 203839 11490 42405891
Therapeutic reaction time decreased 24.24 10.47 39 203915 2039 42415342
Acute graft versus host disease 24.00 10.47 5 203949 8210 42409171
Hypersomnia 23.72 10.47 135 203819 14483 42402898
Hospice care 23.69 10.47 92 203862 8421 42408960
Contusion 23.68 10.47 306 203648 41679 42375702
Hyperthermia 22.98 10.47 16 203938 12558 42404823
Hypercalciuria 22.98 10.47 17 203937 359 42417022
Acute myeloid leukaemia 22.74 10.47 45 203909 22211 42395170
Dandy-Walker syndrome 22.67 10.47 15 203939 263 42417118
Muscular weakness 22.56 10.47 541 203413 82957 42334424
Surgery 22.51 10.47 153 203801 17463 42399918
Hyperglycaemia 22.47 10.47 128 203826 45731 42371650
Upper limb fracture 22.45 10.47 68 203886 5488 42411893
Pleural effusion 22.21 10.47 329 203625 96837 42320544
Dyspnoea exertional 22.10 10.47 350 203604 49798 42367583
Movement disorder 22.08 10.47 133 203821 14565 42402816
Subarachnoid haemorrhage 22.03 10.47 22 203932 14450 42402931
Mucormycosis 21.60 10.47 4 203950 7139 42410242
Heparin-induced thrombocytopenia 21.51 10.47 3 203951 6594 42410787
Hepatitis acute 21.51 10.47 8 203946 8967 42408414
Respiratory tract congestion 21.39 10.47 83 203871 7595 42409786
Alanine aminotransferase increased 21.38 10.47 296 203658 88110 42329271
Sudden death 21.31 10.47 29 203925 16600 42400781
Posterior reversible encephalopathy syndrome 21.28 10.47 18 203936 12803 42404578
Klebsiella infection 21.27 10.47 14 203940 11318 42406063
Depression 21.23 10.47 690 203264 110673 42306708
Incorrect dose administered 21.22 10.47 364 203590 52610 42364771
Aspartate aminotransferase increased 21.01 10.47 252 203702 76911 42340470
Pulmonary oedema 20.89 10.47 159 203795 53113 42364268
White blood cell count decreased 20.78 10.47 683 203271 109713 42307668
Eosinophilic myocarditis 20.63 10.47 29 203925 1344 42416037
Migraine 20.63 10.47 199 203755 25215 42392166
Rib fracture 20.63 10.47 143 203811 16428 42400953
Gastrointestinal haemorrhage 20.61 10.47 336 203618 97390 42319991
Erythema multiforme 20.60 10.47 11 203943 9966 42407415
Gastrointestinal infection 20.53 10.47 75 203879 6668 42410713
Psoriatic arthropathy 20.51 10.47 196 203758 24771 42392610
Encephalopathy 20.45 10.47 115 203839 41218 42376163
Prostate cancer metastatic 20.41 10.47 74 203880 6555 42410826
Essential hypertension 20.06 10.47 51 203903 3717 42413664
Acute generalised exanthematous pustulosis 20.03 10.47 8 203946 8587 42408794
Child abuse 20.01 10.47 23 203931 869 42416512
Right atrial hypertrophy 20.00 10.47 21 203933 716 42416665
Epidural lipomatosis 19.94 10.47 33 203921 1767 42415614
Mucous stools 19.80 10.47 40 203914 2500 42414881
Injection site bruising 19.74 10.47 108 203846 11417 42405964
Pulmonary alveolar haemorrhage 19.72 10.47 130 203824 14686 42402695
Gait inability 19.63 10.47 181 203773 22652 42394729
Cardiac disorder 19.52 10.47 336 203618 48596 42368785
Brain oedema 19.42 10.47 30 203924 16297 42401084
Chronic sinusitis 19.20 10.47 47 203907 3345 42414036
Urinary tract infection 19.14 10.47 616 203338 98668 42318713
Hypoacusis 19.09 10.47 154 203800 18548 42398833
Asphyxia 19.00 10.47 8 203946 8318 42409063
Paraesthesia 18.96 10.47 473 203481 72986 42344395
Myocardial ischaemia 18.95 10.47 35 203919 17727 42399654
Joint ankylosis 18.92 10.47 31 203923 1646 42415735
Neoplasm progression 18.89 10.47 73 203881 28927 42388454
Pre-existing condition improved 18.89 10.47 43 203911 2920 42414461
Blood testosterone decreased 18.88 10.47 59 203895 4843 42412538
Weight fluctuation 18.81 10.47 67 203887 5884 42411497
Suicidal ideation 18.76 10.47 144 203810 48017 42369364
Psychotic disorder 18.72 10.47 74 203880 29134 42388247
Brain natriuretic peptide increased 18.71 10.47 73 203881 6697 42410684
Pulmonary toxicity 18.68 10.47 9 203945 8646 42408735
Acute myocardial infarction 18.62 10.47 183 203771 57982 42359399
Polyneuropathy in malignant disease 18.61 10.47 15 203939 361 42417020
Drug eruption 18.53 10.47 53 203901 23022 42394359
Gastroenteritis viral 18.43 10.47 83 203871 8116 42409265
Multiple allergies 18.35 10.47 49 203905 3679 42413702
Carcinoid tumour 18.35 10.47 13 203941 256 42417125
Neck pain 18.32 10.47 222 203732 29792 42387589
Limb discomfort 18.21 10.47 114 203840 12653 42404728
Neutrophil count decreased 18.07 10.47 205 203749 63210 42354171
Chest discomfort 18.05 10.47 415 203539 63201 42354180
Hypothermia 17.96 10.47 20 203934 12495 42404886
Specific gravity urine increased 17.82 10.47 11 203943 170 42417211
Dystonia 17.74 10.47 21 203933 12769 42404612
BK virus infection 17.68 10.47 10 203944 8774 42408607
Blood calcium decreased 17.64 10.47 102 203852 11006 42406375
Osteopenia 17.60 10.47 68 203886 6210 42411171
Back disorder 17.60 10.47 77 203877 7437 42409944
Prostatomegaly 17.39 10.47 67 203887 6110 42411271
Hypertensive crisis 17.35 10.47 14 203940 10192 42407189
JC polyomavirus test positive 17.34 10.47 23 203931 1008 42416373
Intentional product misuse 17.29 10.47 201 203753 61699 42355682
Hyperammonaemia 17.25 10.47 8 203946 7858 42409523
Secondary progressive multiple sclerosis 17.22 10.47 15 203939 403 42416978
Squamous cell carcinoma of skin 17.15 10.47 112 203842 12614 42404767
Tooth disorder 17.11 10.47 107 203847 11872 42405509
Device issue 17.06 10.47 117 203837 13392 42403989
Hallucination, auditory 17.03 10.47 28 203926 14836 42402545
Pre-eclampsia 17.01 10.47 7 203947 42 42417339
Coagulopathy 17.00 10.47 52 203902 22110 42395271
Restlessness 16.96 10.47 77 203877 29172 42388209
Rash pruritic 16.93 10.47 240 203714 33363 42384018
Heart rate irregular 16.84 10.47 133 203821 15917 42401464
Haemolytic anaemia 16.73 10.47 20 203934 12107 42405274
Bone cancer 16.60 10.47 31 203923 1828 42415553
Nerve degeneration 16.57 10.47 11 203943 194 42417187
Pulmonary fibrosis 16.57 10.47 198 203756 26483 42390898
Trisomy 21 16.54 10.47 17 203937 565 42416816
Vitamin B12 decreased 16.52 10.47 29 203925 1629 42415752
Skin injury 16.47 10.47 38 203916 2603 42414778
Fracture nonunion 16.47 10.47 11 203943 196 42417185
Enterococcal infection 16.45 10.47 20 203934 12019 42405362
Hyperthyroidism 16.44 10.47 27 203927 14314 42403067
Gastrointestinal disorder 16.38 10.47 314 203640 46339 42371042
Cellulitis 16.32 10.47 398 203556 61187 42356194
Congenital supraventricular tachycardia 16.29 10.47 5 203949 10 42417371
Mydriasis 16.24 10.47 11 203943 8759 42408622
Congestive cardiomyopathy 16.22 10.47 11 203943 8753 42408628
Ketoacidosis 16.18 10.47 3 203951 5349 42412032
Eosinophil percentage increased 16.18 10.47 17 203937 580 42416801
Condition aggravated 16.13 10.47 1453 202501 259301 42158080
Diabetic ketoacidosis 16.10 10.47 54 203900 22313 42395068
Neurodevelopmental disorder 16.04 10.47 15 203939 443 42416938
Obesity 15.98 10.47 134 203820 16325 42401056
Inability to afford medication 15.96 10.47 33 203921 2097 42415284
Atrial septal defect 15.96 10.47 9 203945 7910 42409471
Parosmia 15.92 10.47 76 203878 7615 42409766
Pneumonia aspiration 15.84 10.47 158 203796 49920 42367461
Small for dates baby 15.80 10.47 3 203951 5260 42412121
Clostridium difficile infection 15.80 10.47 172 203782 22487 42394894
Tachypnoea 15.79 10.47 52 203902 21610 42395771
Suspected suicide 15.76 10.47 5 203949 6194 42411187
Tooth infection 15.75 10.47 78 203876 7933 42409448
Unresponsive to stimuli 15.73 10.47 87 203867 31316 42386065
Pneumonitis 15.66 10.47 126 203828 41592 42375789
Renal tubular necrosis 15.60 10.47 41 203913 18313 42399068
Psychomotor skills impaired 15.56 10.47 3 203951 5201 42412180
Rubber sensitivity 15.53 10.47 14 203940 394 42416987
Drug withdrawal syndrome 15.52 10.47 52 203902 21497 42395884
Stomatitis 15.42 10.47 160 203794 50169 42367212
Bone cyst 15.33 10.47 28 203926 1623 42415758
Macrocephaly 15.26 10.47 15 203939 472 42416909
Blood immunoglobulin E increased 15.25 10.47 45 203909 3580 42413801
Temperature intolerance 15.21 10.47 54 203900 4734 42412647
Fluid retention 15.20 10.47 224 203730 31395 42385986
Transplant rejection 15.19 10.47 26 203928 13562 42403819
Hyperexplexia 15.16 10.47 6 203948 32 42417349
Haemodialysis 15.16 10.47 16 203938 10244 42407137
Dermatitis bullous 15.14 10.47 11 203943 8445 42408936
Hand fracture 15.13 10.47 39 203915 2867 42414514
Infusion site extravasation 15.06 10.47 59 203895 5422 42411959
Arrhythmia 15.03 10.47 122 203832 40195 42377186
Pleural thickening 15.00 10.47 15 203939 482 42416899
Intentional product use issue 14.98 10.47 450 203504 71383 42345998
Bone pain 14.96 10.47 177 203777 23615 42393766
Purpura 14.94 10.47 21 203933 11858 42405523
Colitis ischaemic 14.87 10.47 8 203946 7218 42410163
Joint lock 14.82 10.47 25 203929 1360 42416021
Adenovirus infection 14.82 10.47 7 203947 6802 42410579
Anti-cyclic citrullinated peptide antibody positive 14.78 10.47 30 203924 1882 42415499
Musculoskeletal disorder 14.77 10.47 67 203887 6571 42410810
Cardiovascular somatic symptom disorder 14.72 10.47 6 203948 35 42417346
Full blood count increased 14.65 10.47 21 203933 991 42416390
Organising pneumonia 14.56 10.47 9 203945 7523 42409858
Disorientation 14.55 10.47 108 203846 36281 42381100
Acute pulmonary oedema 14.54 10.47 12 203942 8639 42408742
Hepatitis fulminant 14.53 10.47 3 203951 4956 42412425
Neonatal epileptic seizure 14.52 10.47 7 203947 64 42417317
Oesophageal carcinoma 14.46 10.47 15 203939 9681 42407700
Attention deficit hyperactivity disorder 14.45 10.47 40 203914 3068 42414313
Joint swelling 14.42 10.47 427 203527 67595 42349786
Wound 14.37 10.47 135 203819 16982 42400399
Blood potassium decreased 14.34 10.47 155 203799 20229 42397152
Skin cancer 14.32 10.47 99 203855 11363 42406018
Primary familial brain calcification 14.31 10.47 6 203948 38 42417343
Urine leukocyte esterase positive 14.26 10.47 14 203940 440 42416941
Expanded disability status scale score increased 14.26 10.47 14 203940 440 42416941
Blood iron decreased 14.23 10.47 64 203890 6254 42411127
Hand deformity 14.19 10.47 45 203909 3723 42413658
Blood parathyroid hormone decreased 14.18 10.47 27 203927 1616 42415765
Fear 14.17 10.47 19 203935 10946 42406435
Loss of consciousness 14.16 10.47 335 203619 92019 42325362
White blood cells urine positive 14.10 10.47 25 203929 1416 42415965
Ankylosing spondylitis 14.08 10.47 69 203885 6987 42410394
Arteriosclerosis coronary artery 14.07 10.47 144 203810 18533 42398848
Heart rate increased 14.06 10.47 344 203610 52911 42364470
Oncologic complication 14.03 10.47 14 203940 449 42416932
Growth hormone deficiency 13.98 10.47 12 203942 316 42417065
Hypoalbuminaemia 13.94 10.47 34 203920 15576 42401805
Dermatitis exfoliative 13.85 10.47 8 203946 6939 42410442
Skin toxicity 13.85 10.47 7 203947 6542 42410839
Micturition urgency 13.83 10.47 101 203853 11797 42405584
Capillaritis 13.83 10.47 32 203922 2196 42415185
Milk-alkali syndrome 13.83 10.47 17 203937 690 42416691
Hypertriglyceridaemia 13.65 10.47 17 203937 10109 42407272
Femur fracture 13.62 10.47 87 203867 9725 42407656
Arteriospasm coronary 13.61 10.47 3 203951 4735 42412646
Foreign body in throat 13.60 10.47 15 203939 541 42416840
Cardiac failure acute 13.56 10.47 28 203926 13605 42403776
Skin fissures 13.55 10.47 86 203868 9590 42407791
Abdominal pain upper 13.52 10.47 503 203451 82106 42335275
Compression fracture 13.47 10.47 44 203910 3698 42413683
Cyst 13.46 10.47 56 203898 5290 42412091
Therapeutic response unexpected 13.46 10.47 97 203857 11284 42406097
Band sensation 13.41 10.47 8 203946 116 42417265
Atrioventricular block complete 13.40 10.47 21 203933 11343 42406038
Dry eye 13.37 10.47 123 203831 15383 42401998
Graft versus host disease in gastrointestinal tract 13.34 10.47 4 203950 5139 42412242
Intracranial pressure increased 13.34 10.47 3 203951 4671 42412710
Rash 13.33 10.47 1517 202437 275437 42141944
Graft versus host disease 13.32 10.47 26 203928 12899 42404482
Juvenile idiopathic arthritis 13.31 10.47 35 203919 2604 42414777
Lower limb fracture 13.27 10.47 53 203901 4914 42412467
Sneezing 13.26 10.47 63 203891 6300 42411081
Cyanosis 13.22 10.47 33 203921 14998 42402383
Low birth weight baby 13.12 10.47 17 203937 9938 42407443
Cardiomegaly 13.10 10.47 39 203915 16727 42400654
Cytomegalovirus chorioretinitis 13.08 10.47 3 203951 4608 42412773
Pancreatitis 13.07 10.47 138 203816 43130 42374251
Hypogammaglobulinaemia 13.07 10.47 23 203931 11868 42405513
Sphincter of Oddi dysfunction 13.05 10.47 10 203944 223 42417158
Bladder polypectomy 13.04 10.47 3 203951 0 42417381
Dental caries 13.03 10.47 52 203902 4820 42412561
Rheumatoid arthritis 13.03 10.47 280 203674 42160 42375221
Transurethral prostatectomy 13.02 10.47 13 203941 417 42416964
Pulmonary tuberculosis 13.02 10.47 5 203949 5496 42411885
Increased upper airway secretion 12.99 10.47 34 203920 2522 42414859
Ataxia 12.96 10.47 126 203828 15999 42401382
Sickle cell anaemia with crisis 12.93 10.47 52 203902 4838 42412543
Hip arthroplasty 12.91 10.47 55 203899 5250 42412131
Blood pressure abnormal 12.87 10.47 87 203867 9911 42407470
Ear infection 12.84 10.47 105 203849 12699 42404682
Face oedema 12.82 10.47 29 203925 13637 42403744
Gastric haemorrhage 12.82 10.47 19 203935 10496 42406885
Necrosis 12.78 10.47 8 203946 6643 42410738
Bone hypertrophy 12.77 10.47 11 203943 291 42417090
Myocarditis 12.77 10.47 47 203907 18891 42398490
Hyperparathyroidism tertiary 12.72 10.47 6 203948 52 42417329
Gastric pH increased 12.72 10.47 4 203950 9 42417372
Neonatal respiratory distress syndrome 12.68 10.47 3 203951 4510 42412871
Lung neoplasm malignant 12.60 10.47 48 203906 19099 42398282
Duodenal ulcer haemorrhage 12.60 10.47 6 203948 5802 42411579
Benign abdominal neoplasm 12.53 10.47 7 203947 89 42417292
Furuncle 12.52 10.47 43 203911 3707 42413674
Skin discolouration 12.52 10.47 154 203800 20736 42396645
Neutropenic colitis 12.50 10.47 3 203951 4467 42412914
Glossodynia 12.49 10.47 46 203908 4106 42413275
Complications of transplanted kidney 12.44 10.47 5 203949 5345 42412036
Albumin globulin ratio increased 12.43 10.47 6 203948 55 42417326
Bone marrow oedema 12.41 10.47 18 203936 859 42416522
Stress 12.41 10.47 288 203666 43924 42373457
Acidosis 12.40 10.47 25 203929 12254 42405127
Congenital coronary artery malformation 12.34 10.47 6 203948 56 42417325
Diffuse large B-cell lymphoma recurrent 12.32 10.47 4 203950 4882 42412499
Faeces hard 12.30 10.47 26 203928 1678 42415703
Nonspecific reaction 12.23 10.47 25 203929 1576 42415805
Hordeolum 12.22 10.47 25 203929 1577 42415804
Refusal of treatment by patient 12.21 10.47 5 203949 5286 42412095
Ventricular septal defect 12.21 10.47 3 203951 4396 42412985
Spinal operation 12.07 10.47 46 203908 4174 42413207
Hyperparathyroidism 12.02 10.47 22 203932 1277 42416104
Concussion 11.99 10.47 35 203919 2767 42414614
Bone scan abnormal 11.98 10.47 6 203948 60 42417321
Sleep disorder 11.91 10.47 308 203646 47787 42369594
Crystal arthropathy 11.90 10.47 6 203948 61 42417320
Insurance issue 11.88 10.47 45 203909 4071 42413310
Candida infection 11.88 10.47 58 203896 21552 42395829
Chest expansion decreased 11.86 10.47 8 203946 145 42417236
Nocardiosis 11.82 10.47 5 203949 5185 42412196
Bone density abnormal 11.82 10.47 8 203946 146 42417235
Pneumatosis intestinalis 11.79 10.47 4 203950 4748 42412633
Stress fracture 11.79 10.47 19 203935 995 42416386
Enterocolitis infectious 11.79 10.47 28 203926 1955 42415426
Cystitis 11.76 10.47 96 203858 11602 42405779
Swollen joint count decreased 11.76 10.47 10 203944 260 42417121
Tender joint count decreased 11.76 10.47 10 203944 260 42417121
Liver disorder 11.75 10.47 127 203827 39517 42377864
Anal fissure 11.75 10.47 53 203901 5186 42412195
Staphylococcal sepsis 11.73 10.47 23 203931 11391 42405990
Injection site erythema 11.73 10.47 148 203806 20047 42397334
Ejection fraction decreased 11.73 10.47 60 203894 22027 42395354
Small intestinal obstruction 11.66 10.47 129 203825 16932 42400449
Vasculitis 11.64 10.47 137 203817 18257 42399124
Infusion site erythema 11.64 10.47 41 203913 3581 42413800
Ileal stenosis 11.63 10.47 27 203927 1857 42415524
Hepatic encephalopathy 11.62 10.47 40 203914 16402 42400979
Bronchitis 11.61 10.47 302 203652 46899 42370482
Cystic fibrosis respiratory infection suppression 11.60 10.47 10 203944 265 42417116
Drug-induced liver injury 11.59 10.47 122 203832 38151 42379230
Erysipelas 11.52 10.47 8 203946 6288 42411093
Ankle fracture 11.50 10.47 50 203904 4816 42412565
Immunosuppressant drug level increased 11.49 10.47 12 203942 7719 42409662
Psychiatric decompensation 11.48 10.47 3 203951 4219 42413162
Anorectal discomfort 11.47 10.47 30 203924 2225 42415156
Ventricular arrhythmia 11.46 10.47 8 203946 6271 42411110
Blood test abnormal 11.45 10.47 103 203851 12803 42404578
Therapeutic response shortened 11.43 10.47 107 203847 13447 42403934
Scab 11.39 10.47 57 203897 5821 42411560
Burning sensation 11.37 10.47 152 203802 20861 42396520
Acute coronary syndrome 11.31 10.47 35 203919 14830 42402551
Multiple-drug resistance 11.30 10.47 11 203943 7311 42410070
Toxic encephalopathy 11.25 10.47 10 203944 6943 42410438
Nerve injury 11.25 10.47 43 203911 3907 42413474
Osteonecrosis of jaw 11.23 10.47 140 203814 18909 42398472
Monocyte percentage increased 11.23 10.47 19 203935 1036 42416345
Oliguria 11.18 10.47 17 203937 9296 42408085
Increased tendency to bruise 11.18 10.47 46 203908 4324 42413057
Exposure to toxic agent 11.12 10.47 5 203949 4999 42412382
Limb injury 11.11 10.47 111 203843 14194 42403187
Lung hernia 11.11 10.47 6 203948 71 42417310
Regurgitation 11.11 10.47 27 203927 1913 42415468
Unevaluable event 11.10 10.47 228 203726 34060 42383321
Calciphylaxis 11.03 10.47 20 203934 1153 42416228
Gastric disorder 11.01 10.47 96 203858 11826 42405555
Gingival pain 10.99 10.47 74 203880 8420 42408961
Bone giant cell tumour benign 10.98 10.47 3 203951 3 42417378
Plaque shift 10.98 10.47 3 203951 3 42417378
Tinea cruris 10.96 10.47 13 203941 508 42416873
Sinus disorder 10.94 10.47 71 203883 7979 42409402
Lactose intolerance 10.90 10.47 23 203931 1483 42415898
Muscle tightness 10.87 10.47 54 203900 5499 42411882
Victim of child abuse 10.83 10.47 20 203934 1169 42416212
Congenital central nervous system anomaly 10.76 10.47 15 203939 690 42416691
Obstruction 10.73 10.47 36 203918 3067 42414314
Encephalitis 10.73 10.47 17 203937 9141 42408240
Renal tubular dysfunction 10.68 10.47 12 203942 442 42416939
Immune effector cell-associated neurotoxicity syndrome 10.67 10.47 18 203936 9443 42407938
High turnover osteopathy 10.63 10.47 5 203949 43 42417338
Anal fissure haemorrhage 10.62 10.47 6 203948 78 42417303
C-reactive protein decreased 10.62 10.47 29 203925 2207 42415174
Foot fracture 10.59 10.47 58 203896 6133 42411248
Cervical vertebral fracture 10.58 10.47 30 203924 2333 42415048
Rhonchi 10.55 10.47 28 203926 2095 42415286
Back injury 10.52 10.47 45 203909 4303 42413078
Oesophageal dilation procedure 10.52 10.47 3 203951 4 42417377
Faeces soft 10.50 10.47 49 203905 4863 42412518

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1698.29 9.92 536 732334 480019 109376410
Drug interaction 1112.80 9.92 1006 731864 499177 109357252
Completed suicide 995.11 9.92 198 732672 242183 109614246
Acute kidney injury 928.48 9.92 1750 731120 633680 109222749
Drug abuse 736.39 9.92 141 732729 177270 109679159
Intentional overdose 576.70 9.92 93 732777 132408 109724021
Overdose 506.49 9.92 481 732389 233313 109623116
Fatigue 489.05 9.92 11005 721865 1204953 108651476
Thrombocytopenia 470.90 9.92 1005 731865 347880 109508549
Product dose omission issue 454.42 9.92 3666 729204 318116 109538313
Multiple sclerosis relapse 442.99 9.92 1009 731861 49231 109807198
Multiple organ dysfunction syndrome 427.75 9.92 236 732634 151474 109704955
Hepatic function abnormal 411.07 9.92 53 732817 89242 109767187
Hypotension 407.75 9.92 1934 730936 521915 109334514
Myelosuppression 406.54 9.92 68 732802 94272 109762157
Febrile neutropenia 396.90 9.92 950 731920 315817 109540612
Cardiac arrest 351.72 9.92 473 732397 196280 109660149
Asthma 348.57 9.92 2843 730027 247448 109608981
Cardio-respiratory arrest 341.61 9.92 170 732700 115666 109740763
Pancytopenia 338.43 9.92 541 732329 209072 109647357
Cardiac failure 328.39 9.92 458 732412 187168 109669261
Neutropenia 325.92 9.92 1326 731544 373294 109483135
Hepatic cytolysis 315.40 9.92 11 732859 55042 109801387
Septic shock 313.97 9.92 348 732522 157180 109699249
Drug reaction with eosinophilia and systemic symptoms 310.83 9.92 80 732790 82015 109774414
Drug ineffective 305.16 9.92 7715 725155 1512825 108343604
Hyperkalaemia 297.98 9.92 276 732594 135520 109720909
Rhabdomyolysis 289.56 9.92 224 732646 120177 109736252
Hyponatraemia 287.68 9.92 634 732236 217019 109639410
Headache 285.29 9.92 7758 725112 874619 108981810
Suicide attempt 282.62 9.92 167 732703 103227 109753202
Rheumatoid arthritis 274.68 9.92 3116 729754 296497 109559932
Depressed level of consciousness 266.08 9.92 212 732658 112066 109744363
Lactic acidosis 260.68 9.92 145 732725 92666 109763763
Wheezing 260.06 9.92 2711 730159 252519 109603910
Electrocardiogram QT prolonged 254.14 9.92 209 732661 108751 109747678
Muscle spasms 254.11 9.92 2891 729979 275266 109581163
Pain in extremity 250.40 9.92 4577 728293 482541 109373888
Respiratory failure 248.57 9.92 673 732197 214659 109641770
Coma 247.63 9.92 249 732621 117620 109738809
Mucosal inflammation 238.73 9.92 173 732697 95968 109760461
Interstitial lung disease 236.00 9.92 348 732522 138986 109717443
Agranulocytosis 230.35 9.92 62 732808 61698 109794731
Anaemia 226.25 9.92 2425 730445 544661 109311768
Sopor 221.81 9.92 4 732866 36542 109819887
Cholestasis 218.64 9.92 77 732793 64441 109791988
Cytomegalovirus infection 218.07 9.92 47 732823 54397 109802032
Muscle spasticity 216.52 9.92 625 732245 35290 109821139
Infective pulmonary exacerbation of cystic fibrosis 215.95 9.92 367 732503 14404 109842025
Pain 211.42 9.92 8025 724845 946930 108909499
Renal failure 205.81 9.92 788 732082 225786 109630643
Back pain 203.32 9.92 3522 729348 367474 109488955
Angioedema 201.35 9.92 213 732657 98287 109758142
Hepatocellular injury 200.24 9.92 45 732825 50597 109805832
Bradycardia 198.95 9.92 461 732409 155056 109701373
Arthralgia 198.89 9.92 6659 726211 772973 109083456
Metabolic acidosis 198.01 9.92 221 732649 99523 109756906
Hypoaesthesia 196.25 9.92 3048 729822 311175 109545254
Hypokalaemia 188.92 9.92 600 732270 181848 109674581
Sepsis 187.65 9.92 1333 731537 326013 109530416
Cytokine release syndrome 187.32 9.92 117 732753 70189 109786240
Altered state of consciousness 181.65 9.92 77 732793 57549 109798880
Rash maculo-papular 181.12 9.92 136 732734 74086 109782343
Sinusitis 178.47 9.92 2860 730010 293828 109562601
Tachycardia 175.87 9.92 837 732033 225808 109630621
Serotonin syndrome 169.64 9.92 90 732780 59063 109797366
Sleep disorder due to a general medical condition 167.89 9.92 738 732132 51374 109805055
Bone marrow failure 167.39 9.92 87 732783 57761 109798668
Shock 163.56 9.92 75 732795 53513 109802916
Drug resistance 162.80 9.92 85 732785 56289 109800140
Hepatic failure 162.59 9.92 130 732740 68609 109787820
Multiple sclerosis 162.50 9.92 455 732415 25243 109831186
Psoriatic arthropathy 162.37 9.92 2006 730864 194755 109661674
Neuroleptic malignant syndrome 162.22 9.92 18 732852 34041 109822388
Full blood count abnormal 159.24 9.92 765 732105 55287 109801142
Nasopharyngitis 158.18 9.92 3572 729298 390789 109465640
Fall 156.90 9.92 5167 727703 598315 109258114
Gait disturbance 156.63 9.92 2653 730217 275555 109580874
Insomnia 153.45 9.92 3294 729576 357296 109499133
Renal impairment 153.27 9.92 684 732186 187761 109668668
Malignant neoplasm progression 152.84 9.92 616 732254 173951 109682478
Leukopenia 152.16 9.92 492 732378 148299 109708130
Colitis ulcerative 150.64 9.92 953 731917 76410 109780019
Cerebral infarction 149.94 9.92 78 732792 51760 109804669
Peripheral swelling 147.75 9.92 3613 729257 400421 109456008
Anaphylactic shock 146.97 9.92 79 732791 51467 109804962
Memory impairment 145.30 9.92 1967 730903 194977 109661452
Poisoning 144.84 9.92 13 732857 29092 109827337
Rhinorrhoea 144.28 9.92 1169 731701 101497 109754932
Influenza like illness 143.39 9.92 1041 731829 87371 109769058
Acute respiratory distress syndrome 141.08 9.92 89 732781 53109 109803320
Pyrexia 140.90 9.92 4710 728160 893555 108962874
Hypoglycaemia 139.16 9.92 356 732514 115748 109740681
Intentional self-injury 135.08 9.92 40 732830 37389 109819040
Toxic skin eruption 135.03 9.92 13 732857 27502 109828927
Feeling abnormal 133.77 9.92 1806 731064 178905 109677524
Drug ineffective for unapproved indication 129.78 9.92 307 732563 102531 109753898
Nasal oedema 129.09 9.92 191 732679 6648 109849781
Abdominal pain upper 127.03 9.92 3120 729750 345991 109510438
Bone giant cell tumour 125.69 9.92 41 732829 67 109856362
Jaundice 124.56 9.92 125 732745 59111 109797318
Pneumocystis jirovecii pneumonia 124.05 9.92 64 732806 42671 109813758
Respiratory arrest 122.61 9.92 123 732747 58176 109798253
Gastrooesophageal reflux disease 122.45 9.92 1772 731098 178204 109678225
Cardiogenic shock 121.71 9.92 120 732750 57218 109799211
Night sweats 121.52 9.92 1391 731479 132592 109723837
Stevens-Johnson syndrome 120.92 9.92 81 732789 46820 109809609
Influenza 120.68 9.92 1679 731191 167422 109689007
Toxic epidermal necrolysis 120.09 9.92 119 732751 56608 109799821
Melaena 120.08 9.92 168 732702 68589 109787840
Agitation 119.67 9.92 368 732502 112683 109743746
Circulatory collapse 119.52 9.92 68 732802 42925 109813504
Acute hepatic failure 119.39 9.92 46 732824 36422 109820007
Sedation 118.99 9.92 173 732697 69510 109786919
Anaphylactic reaction 118.22 9.92 376 732494 113924 109742505
Ascites 117.96 9.92 276 732594 92532 109763897
Neurotoxicity 116.99 9.92 67 732803 42140 109814289
Cough 116.89 9.92 3941 728929 457700 109398729
Mycotic allergy 116.31 9.92 169 732701 5785 109850644
Neutropenic sepsis 116.30 9.92 30 732840 30716 109825713
Extrapyramidal disorder 115.45 9.92 25 732845 28842 109827587
Disseminated intravascular coagulation 115.21 9.92 65 732805 41221 109815208
Bronchopulmonary aspergillosis 115.17 9.92 28 732842 29835 109826594
Bone pain 115.04 9.92 783 732087 64350 109792079
Hepatotoxicity 111.63 9.92 154 732716 63246 109793183
Gastrointestinal haemorrhage 110.61 9.92 643 732227 164875 109691554
Ventricular tachycardia 110.43 9.92 101 732769 49908 109806521
Blood creatine phosphokinase increased 108.35 9.92 199 732671 72878 109783551
Burning sensation 107.71 9.92 807 732063 68405 109788024
Dermatitis atopic 106.51 9.92 392 732478 25149 109831280
Muscular weakness 106.34 9.92 2272 730598 246196 109610233
Blood bilirubin increased 105.58 9.92 215 732655 75757 109780672
Gait inability 104.67 9.92 1372 731498 135004 109721425
Haemophagocytic lymphohistiocytosis 104.66 9.92 39 732831 31520 109824909
Vitamin D deficiency 104.34 9.92 315 732555 18237 109838192
Posterior reversible encephalopathy syndrome 102.39 9.92 48 732822 33813 109822616
Thrombotic microangiopathy 101.87 9.92 33 732837 29116 109827313
Vitamin D decreased 100.72 9.92 239 732631 11976 109844453
Disease progression 99.75 9.92 1084 731786 242950 109613479
Oedema 99.74 9.92 1950 730920 208026 109648403
Myocardial infarction 99.20 9.92 805 732065 191278 109665151
Loss of personal independence in daily activities 98.47 9.92 1468 731402 148552 109707877
Encephalopathy 98.32 9.92 247 732623 80808 109775621
Haematotoxicity 98.27 9.92 12 732858 21070 109835359
Aggression 98.18 9.92 150 732720 59060 109797369
Torsade de pointes 98.00 9.92 16 732854 22584 109833845
Paraesthesia 96.90 9.92 2459 730411 274062 109582367
Ear pain 95.88 9.92 643 732227 52583 109803846
Musculoskeletal stiffness 95.61 9.92 2480 730390 277342 109579087
Ventricular fibrillation 95.38 9.92 80 732790 41233 109815196
Frequent bowel movements 95.00 9.92 803 732067 70587 109785842
Dyspepsia 94.29 9.92 1784 731086 189181 109667248
Respiratory tract congestion 94.13 9.92 430 732440 30427 109826002
Diarrhoea 93.84 9.92 8766 724104 1130739 108725690
Hyperbilirubinaemia 93.48 9.92 43 732827 30628 109825801
Mydriasis 93.19 9.92 17 732853 22140 109834289
Contusion 92.60 9.92 2111 730759 231250 109625179
Drug level increased 92.23 9.92 108 732762 47611 109808818
Haematemesis 92.12 9.92 156 732714 58952 109797477
Status epilepticus 92.06 9.92 47 732823 31524 109824905
Cytomegalovirus infection reactivation 91.74 9.92 8 732862 18325 109838104
International normalised ratio increased 91.45 9.92 283 732587 86489 109769940
Sinus disorder 91.03 9.92 444 732426 32284 109824145
Asthenia 90.59 9.92 5502 727368 683497 109172932
Cerebral haemorrhage 90.16 9.92 184 732686 64784 109791645
Miosis 90.05 9.92 18 732852 21965 109834464
Respiratory distress 89.81 9.92 202 732668 68672 109787757
Carpal tunnel syndrome 89.28 9.92 341 732529 22269 109834160
Osteoarthritis 89.11 9.92 1703 731167 180920 109675509
Therapy partial responder 89.02 9.92 69 732801 36992 109819437
Sensitisation 88.73 9.92 123 732747 4028 109852401
Polycystic ovaries 87.74 9.92 132 732738 4664 109851765
Therapeutic product effect incomplete 87.70 9.92 2021 730849 221784 109634645
Liver function test abnormal 86.86 9.92 206 732664 68744 109787685
Pleural effusion 86.69 9.92 756 732114 176953 109679476
Tumour lysis syndrome 86.65 9.92 48 732822 30753 109825676
Febrile bone marrow aplasia 86.37 9.92 8 732862 17457 109838972
Body height decreased 85.29 9.92 205 732665 10358 109846071
Dry mouth 84.46 9.92 1825 731045 198123 109658306
Death 84.25 9.92 3779 729091 695090 109161339
Nasal congestion 84.07 9.92 1009 731861 97273 109759156
Blood lactate dehydrogenase increased 83.92 9.92 102 732768 44232 109812197
Fibromyalgia 83.12 9.92 1593 731277 169316 109687113
Full blood count decreased 82.59 9.92 426 732444 31673 109824756
Brain oedema 82.50 9.92 52 732818 31046 109825383
Migraine 82.49 9.92 1597 731273 170055 109686374
Acute generalised exanthematous pustulosis 82.21 9.92 21 732849 21643 109834786
Dry skin 82.17 9.92 1082 731788 106571 109749858
Inappropriate schedule of product administration 82.00 9.92 1846 731024 201791 109654638
Limb discomfort 81.22 9.92 506 732364 40348 109816081
Myoclonus 81.10 9.92 60 732810 32938 109823491
Mobility decreased 81.02 9.92 2104 730766 235318 109621111
Anuria 80.86 9.92 30 732840 24311 109832118
Venoocclusive liver disease 80.77 9.92 5 732865 15202 109841227
Lower limb fracture 80.77 9.92 809 732061 74539 109781890
Hypervitaminosis D 80.72 9.92 32 732838 115 109856314
Psychotic disorder 80.71 9.92 133 732737 50804 109805625
Acute myeloid leukaemia 80.61 9.92 80 732790 38030 109818399
Labelled drug-drug interaction medication error 80.52 9.92 47 732823 29255 109827174
Post transplant lymphoproliferative disorder 80.39 9.92 6 732864 15607 109840822
Cardiotoxicity 80.20 9.92 9 732861 16872 109839557
Psoriasis 79.44 9.92 1337 731533 138656 109717773
Urinary tract infection 79.37 9.92 2773 730097 323509 109532920
Hip fracture 79.28 9.92 450 732420 34701 109821728
Weight decreased 79.00 9.92 3826 729044 464231 109392198
Hot flush 77.67 9.92 723 732147 65313 109791116
Seizure 77.54 9.92 1016 731854 220169 109636260
Loss of consciousness 76.26 9.92 882 731988 195424 109661005
Anxiety 76.21 9.92 2901 729969 342177 109514252
Drug use disorder 75.73 9.92 14 732856 18060 109838369
Blood cholesterol increased 75.31 9.92 1678 731192 183107 109673322
Aplastic anaemia 74.21 9.92 34 732836 24274 109832155
Nephropathy toxic 74.20 9.92 45 732825 27433 109828996
Shock haemorrhagic 73.05 9.92 45 732825 27202 109829227
Inappropriate antidiuretic hormone secretion 72.82 9.92 70 732800 33781 109822648
Sneezing 72.49 9.92 410 732460 31574 109824855
Deep vein thrombosis postoperative 71.67 9.92 653 732217 58638 109797791
Eosinophilia 71.47 9.92 175 732695 57761 109798668
Jaundice cholestatic 71.42 9.92 7 732863 14601 109841828
Injection site pain 71.03 9.92 1611 731259 176311 109680118
Neck pain 70.98 9.92 1179 731691 121951 109734478
Productive cough 70.95 9.92 1108 731762 113197 109743232
Hyperglycaemia 70.88 9.92 306 732564 84784 109771645
Intentional product misuse 70.45 9.92 553 732317 132351 109724078
Erythema multiforme 70.08 9.92 26 732844 21071 109835358
Ejection fraction 69.92 9.92 92 732778 2863 109853566
Pancreatitis acute 69.79 9.92 188 732682 60086 109796343
Pollakiuria 69.15 9.92 516 732354 43679 109812750
Alopecia 68.73 9.92 3015 729855 361738 109494691
Coagulopathy 68.45 9.92 103 732767 40808 109815621
Hyperthermia 67.72 9.92 28 732842 21244 109835185
Arthritis 67.71 9.92 1520 731350 166066 109690363
Epstein-Barr virus infection 67.66 9.92 20 732850 18718 109837711
Mixed liver injury 67.20 9.92 3 732867 12076 109844353
Skin haemorrhage 67.04 9.92 334 732536 24493 109831936
Haemodynamic instability 66.84 9.92 34 732836 22854 109833575
Osteopenia 66.64 9.92 308 732562 21901 109834528
Face oedema 66.58 9.92 74 732796 33395 109823034
Aspergillus infection 66.36 9.92 44 732826 25572 109830857
Blood test abnormal 66.02 9.92 368 732502 28186 109828243
Pathogen resistance 65.41 9.92 18 732852 17654 109838775
Gamma-glutamyltransferase increased 65.28 9.92 199 732671 61110 109795319
Gait spastic 65.23 9.92 65 732805 1484 109854945
Alanine aminotransferase increased 65.20 9.92 842 732028 182931 109673498
Cataract 64.93 9.92 809 732061 78676 109777753
Hospitalisation 64.86 9.92 1315 731555 141178 109715251
Bone density decreased 64.21 9.92 243 732627 15799 109840630
Cystitis 64.15 9.92 695 732175 65341 109791088
Ejection fraction decreased 63.61 9.92 108 732762 40772 109815657
Accidental overdose 63.60 9.92 157 732713 51677 109804752
Suspected suicide 63.20 9.92 12 732858 15187 109841242
Mite allergy 63.18 9.92 127 732743 5676 109850753
Conjunctivitis allergic 63.09 9.92 141 732729 6790 109849639
Bone density abnormal 62.45 9.92 101 732769 3802 109852627
Autoimmune disorder 62.14 9.92 686 732184 64797 109791632
Subarachnoid haemorrhage 62.08 9.92 63 732807 29639 109826790
Transaminases increased 61.77 9.92 214 732656 63176 109793253
Schizophrenia 61.42 9.92 34 732836 21792 109834637
COVID-19 61.40 9.92 2090 730780 242970 109613459
Sinus congestion 61.02 9.92 378 732492 30081 109826348
Disorientation 60.81 9.92 251 732619 70420 109786009
Dizziness 60.75 9.92 5394 727476 692799 109163630
Syncope 60.57 9.92 960 731910 201576 109654853
Hypertensive crisis 60.30 9.92 44 732826 24328 109832101
Product administration interrupted 60.03 9.92 188 732682 11104 109845325
Bronchial wall thickening 59.72 9.92 89 732781 3118 109853311
Spirometry abnormal 59.49 9.92 120 732750 5377 109851052
General physical health deterioration 59.38 9.92 2261 730609 423034 109433395
Spinal fracture 59.37 9.92 302 732568 22331 109834098
White blood cell count decreased 59.15 9.92 1963 730907 227427 109629002
Neuritis 59.10 9.92 143 732727 7256 109849173
Acute graft versus host disease 58.43 9.92 8 732862 12873 109843556
Acute myocardial infarction 58.36 9.92 321 732549 83456 109772973
Illness 58.23 9.92 815 732055 81356 109775073
Aspartate aminotransferase increased 58.14 9.92 729 732141 159207 109697222
Ischaemic stroke 57.99 9.92 116 732754 41147 109815282
Respiratory tract infection 57.67 9.92 727 732143 70890 109785539
Hypercalcaemia 57.49 9.92 516 732354 46141 109810288
Relapsing-remitting multiple sclerosis 57.48 9.92 70 732800 2012 109854417
Transplant rejection 57.42 9.92 47 732823 24520 109831909
Injection site bruising 57.17 9.92 555 732315 50708 109805721
Akathisia 57.00 9.92 21 732849 17092 109839337
Cystitis haemorrhagic 56.78 9.92 7 732863 12202 109844227
Skin exfoliation 56.45 9.92 855 732015 86796 109769633
Weight increased 56.34 9.92 3358 729512 416286 109440143
Intentional dose omission 56.26 9.92 273 732597 19807 109836622
Injection site erythema 56.22 9.92 907 731963 93269 109763160
Depression 56.04 9.92 2606 730264 314729 109541700
Atypical femur fracture 56.03 9.92 126 732744 6093 109850336
Rheumatic fever 55.71 9.92 1131 731739 121448 109734981
Acute graft versus host disease in skin 55.66 9.92 4 732866 10736 109845693
Dust allergy 55.65 9.92 123 732747 5878 109850551
Electrocardiogram QRS complex prolonged 54.74 9.92 10 732860 13011 109843418
Pulmonary oedema 54.67 9.92 416 732454 100243 109756186
Neurologic neglect syndrome 54.30 9.92 160 732710 9138 109847291
Injection site pruritus 54.28 9.92 549 732321 50709 109805720
Obstructive airways disorder 54.13 9.92 505 732365 45644 109810785
Respiratory depression 54.09 9.92 80 732790 31921 109824508
Myocarditis 53.92 9.92 72 732798 29983 109826446
Temperature regulation disorder 53.60 9.92 10 732860 12816 109843613
Carotid artery thrombosis 53.59 9.92 163 732707 9475 109846954
Graft versus host disease 53.35 9.92 29 732841 18777 109837652
Sciatica 53.34 9.92 885 731985 91514 109764915
Needle fatigue 53.16 9.92 53 732817 1211 109855218
Hepatitis acute 53.15 9.92 29 732841 18737 109837692
BK virus infection 53.13 9.92 11 732859 13095 109843334
Respiratory symptom 53.05 9.92 218 732652 14727 109841702
Haematuria 53.04 9.92 327 732543 82678 109773751
Sleep apnoea syndrome 52.78 9.92 453 732417 39994 109816435
Mucormycosis 52.21 9.92 5 732865 10623 109845806
Arrhythmia 52.15 9.92 260 732610 69315 109787114
Central nervous system lesion 51.42 9.92 222 732648 15331 109841098
Foetal death 51.27 9.92 21 732849 16024 109840405
Left ventricular dysfunction 51.22 9.92 48 732822 23445 109832984
Somnolence 51.16 9.92 1540 731330 295909 109560520
Generalised tonic-clonic seizure 51.02 9.92 188 732682 54492 109801937
Rheumatoid factor positive 51.00 9.92 1187 731683 130453 109725976
Hallucination, visual 50.95 9.92 117 732753 39488 109816941
Haemodialysis 50.74 9.92 27 732843 17692 109838737
Dystonia 50.30 9.92 58 732812 25747 109830682
Neutrophil count decreased 50.28 9.92 535 732335 120406 109736023
Bronchitis 50.22 9.92 1380 731490 155652 109700777
Wrist fracture 50.15 9.92 209 732661 14208 109842221
Blood pressure increased 49.82 9.92 2141 730729 256232 109600197
Prescribed underdose 49.70 9.92 655 732215 64519 109791910
Injection site reaction 49.55 9.92 848 732022 88222 109768207
Pulmonary vasculitis 49.45 9.92 124 732746 6436 109849993
Hypothermia 49.27 9.92 61 732809 26241 109830188
Cyanosis 48.68 9.92 76 732794 29665 109826764
Malaise 48.64 9.92 5124 727746 666695 109189734
Sensory loss 48.59 9.92 275 732595 21182 109835247
Abdominal distension 48.40 9.92 1511 731359 173592 109682837
Dermatitis bullous 48.33 9.92 28 732842 17501 109838928
Coronary artery disease 48.14 9.92 278 732592 71412 109785017
Balance disorder 47.64 9.92 1059 731811 115501 109740928
Pneumonitis 47.60 9.92 304 732566 76227 109780202
Enterococcal infection 47.55 9.92 39 732831 20327 109836102
Urine leukocyte esterase positive 47.52 9.92 88 732782 3698 109852731
Blood calcium increased 47.52 9.92 241 732629 17799 109838630
Atrioventricular block complete 47.46 9.92 38 732832 20044 109836385
Substance abuse 47.45 9.92 12 732858 12451 109843978
Nephrolithiasis 47.44 9.92 658 732212 65554 109790875
Oropharyngeal pain 47.05 9.92 1202 731668 134074 109722355
Dry eye 46.92 9.92 571 732299 55222 109801207
Pruritus 46.47 9.92 4466 728404 577094 109279335
Sudden death 46.30 9.92 56 732814 24339 109832090
Blood parathyroid hormone increased 46.29 9.92 93 732777 4155 109852274
Adrenal insufficiency 46.28 9.92 136 732734 42254 109814175
Multiple-drug resistance 46.22 9.92 15 732855 13220 109843209
Acute coronary syndrome 46.09 9.92 51 732819 23061 109833368
Sleep disorder 45.99 9.92 1679 731191 196965 109659464
Bradypnoea 45.47 9.92 3 732867 8646 109847783
Abdominal discomfort 45.43 9.92 3111 729759 390747 109465682
Osteoporosis 45.36 9.92 821 732049 86331 109770098
Tubulointerstitial nephritis 45.34 9.92 195 732675 54089 109802340
Toxic encephalopathy 45.34 9.92 22 732848 15192 109841237
Stress 44.92 9.92 963 731907 104385 109752044
Hepatitis fulminant 44.91 9.92 3 732867 8557 109847872
Tachypnoea 44.76 9.92 124 732746 39271 109817158
Hepatitis cholestatic 44.40 9.92 31 732839 17535 109838894
Exposure to toxic agent 44.16 9.92 15 732855 12843 109843586
Bowel movement irregularity 43.96 9.92 131 732739 7529 109848900
Cystic fibrosis 43.91 9.92 97 732773 4634 109851795
Lip dry 43.36 9.92 917 731953 99166 109757263
Myelodysplastic syndrome 43.33 9.92 117 732753 37367 109819062
Plasma cell myeloma 43.30 9.92 621 732249 62315 109794114
Flatulence 43.11 9.92 532 732338 51617 109804812
Eosinophilic granulomatosis with polyangiitis 42.88 9.92 162 732708 10524 109845905
Hallucination, auditory 42.69 9.92 68 732802 26329 109830100
Foot fracture 42.68 9.92 303 732567 25243 109831186
Ileus 42.66 9.92 87 732783 30642 109825787
Hypomania 42.58 9.92 8 732862 10202 109846227
Stress cardiomyopathy 42.52 9.92 26 732844 15780 109840649
Pallor 42.33 9.92 211 732659 56256 109800173
Gastrointestinal disorder 42.28 9.92 1985 730885 239967 109616462
Sinus bradycardia 42.20 9.92 82 732788 29401 109827028
Exostosis 42.04 9.92 478 732392 45478 109810951
Haemolytic anaemia 41.89 9.92 46 732824 20874 109835555
Haematoma 41.86 9.92 222 732648 58254 109798175
Drug eruption 41.68 9.92 198 732672 53461 109802968
Encephalitis 41.65 9.92 38 732832 18801 109837628
Adjustment disorder 41.14 9.92 161 732709 10634 109845795
Myocardial ischaemia 41.05 9.92 71 732799 26613 109829816
Ankle fracture 40.99 9.92 248 732622 19571 109836858
Bone loss 40.87 9.92 73 732797 2982 109853447
JC polyomavirus test positive 40.68 9.92 63 732807 2284 109854145
Injection site mass 40.58 9.92 291 732579 24322 109832107
Red blood cell count decreased 40.51 9.92 638 732232 65285 109791144
Blood pressure abnormal 40.44 9.92 271 732599 22153 109834276
Hyperlactacidaemia 40.44 9.92 4 732866 8282 109848147
Constipation 40.37 9.92 2821 730049 354965 109501464
Diabetic ketoacidosis 40.30 9.92 143 732727 41915 109814514
Hypoalbuminaemia 40.25 9.92 82 732788 28892 109827537
Musculoskeletal pain 40.20 9.92 1538 731332 181485 109674944
Vitamin D increased 40.06 9.92 38 732832 815 109855614
Dysgeusia 39.91 9.92 669 732201 69316 109787113
Taste disorder 39.87 9.92 632 732238 64755 109791674
Respiratory acidosis 39.69 9.92 21 732849 13805 109842624
Bone lesion 39.54 9.92 120 732750 6967 109849462
Neutropenic colitis 39.08 9.92 4 732866 8061 109848368
Pulmonary haemorrhage 39.06 9.92 31 732839 16425 109840004
Palmar-plantar erythrodysaesthesia syndrome 38.97 9.92 140 732730 40885 109815544
Back injury 38.95 9.92 483 732387 46916 109809513
Sinus tachycardia 38.92 9.92 157 732713 44336 109812093
Lacrimation increased 38.49 9.92 343 732527 30607 109825822
Intervertebral disc degeneration 38.49 9.92 228 732642 17857 109838572
Oxygen saturation decreased 38.38 9.92 771 732099 156211 109700218
Thoracic vertebral fracture 38.37 9.92 114 732756 6541 109849888
Lupus vulgaris 38.36 9.92 368 732502 33515 109822914
Skin toxicity 38.34 9.92 15 732855 11768 109844661
Antineutrophil cytoplasmic antibody positive 38.31 9.92 96 732774 4980 109851449
Urine abnormality 38.26 9.92 140 732730 8956 109847473
Surgery 38.04 9.92 430 732440 40853 109815576
Hernia 37.81 9.92 240 732630 19260 109837169
Coma scale abnormal 37.74 9.92 9 732861 9717 109846712
Polyneuropathy 37.70 9.92 99 732771 31913 109824516
Bronchial neoplasm 37.56 9.92 30 732840 506 109855923
Adenovirus infection 37.45 9.92 13 732857 10981 109845448
Wound infection 37.10 9.92 869 732001 95596 109760833
C-reactive protein abnormal 36.85 9.92 1123 731747 128572 109727857
Upper limb fracture 36.81 9.92 251 732619 20637 109835792
Breast cancer 36.67 9.92 404 732466 38138 109818291
Nasal turbinate hypertrophy 36.63 9.92 36 732834 808 109855621
Seasonal allergy 36.57 9.92 240 732630 19482 109836947
Enterocolitis 36.50 9.92 43 732827 18906 109837523
Immunosuppressant drug level increased 36.41 9.92 16 732854 11708 109844721
Road traffic accident 36.39 9.92 951 731919 106447 109749982
Pulmonary tuberculosis 36.37 9.92 8 732862 9131 109847298
Stress fracture 36.36 9.92 118 732752 7103 109849326
Oliguria 36.30 9.92 42 732828 18615 109837814
Skin discolouration 36.19 9.92 490 732380 48556 109807873
Immune effector cell-associated neurotoxicity syndrome 36.17 9.92 27 732843 14755 109841674
Exposure during pregnancy 36.09 9.92 839 732031 166585 109689844
Peritonitis 36.04 9.92 104 732766 32503 109823926
Dermatitis exfoliative 36.02 9.92 15 732855 11332 109845097
Ketoacidosis 36.00 9.92 11 732859 10076 109846353
Cytomegalovirus chorioretinitis 35.97 9.92 3 732867 7125 109849304
Poor venous access 35.95 9.92 282 732588 24240 109832189
Hypomagnesaemia 35.93 9.92 243 732627 60127 109796302
Therapeutic reaction time decreased 35.90 9.92 96 732774 5183 109851246
Unresponsive to stimuli 35.89 9.92 261 732609 63529 109792900
Oral pain 35.86 9.92 393 732477 37051 109819378
Eating disorder 35.35 9.92 336 732534 30522 109825907
Peripheral venous disease 35.24 9.92 767 732103 83350 109773079
Breast cancer stage III 34.96 9.92 727 732143 78390 109778039
Joint range of motion decreased 34.91 9.92 1056 731814 120776 109735653
Heparin-induced thrombocytopenia 34.84 9.92 16 732854 11408 109845021
Intramedullary rod insertion 34.78 9.92 21 732849 219 109856210
Congestive cardiomyopathy 34.75 9.92 26 732844 14193 109842236
Acidosis 34.62 9.92 60 732810 22471 109833958
Ejection fraction abnormal 34.47 9.92 73 732797 3387 109853042
Ear infection 34.44 9.92 596 732274 62136 109794293
Myopathy 34.37 9.92 71 732799 24889 109831540
Personality disorder 34.17 9.92 172 732698 12665 109843764
Parkinsonism 34.16 9.92 59 732811 22128 109834301
Urinary retention 34.16 9.92 296 732574 69387 109787042
Cutaneous vasculitis 34.16 9.92 21 732849 12708 109843721
Pulmonary fibrosis 34.12 9.92 902 731968 101140 109755289
Pre-existing condition improved 34.09 9.92 108 732762 6418 109850011
Intercepted product preparation error 34.06 9.92 3 732867 6817 109849612
Urticaria 34.06 9.92 2503 730367 316354 109540075
Type 2 diabetes mellitus 34.01 9.92 1468 731402 175764 109680665
Lymphoproliferative disorder 33.91 9.92 4 732866 7214 109849215
Cardiac failure acute 33.57 9.92 68 732802 24010 109832419
Orthostatic hypotension 33.56 9.92 279 732591 65970 109790459
Respiratory disorder 33.55 9.92 662 732208 70720 109785709
Nocturia 33.50 9.92 210 732660 16780 109839649
Ileus paralytic 33.44 9.92 18 732852 11719 109844710
Vitamin B12 decreased 33.16 9.92 93 732777 5164 109851265
Hypogammaglobulinaemia 33.15 9.92 51 732819 20025 109836404
Endometrial ablation 33.13 9.92 36 732834 912 109855517
Polyomavirus-associated nephropathy 33.00 9.92 7 732863 8194 109848235
Premature delivery 32.92 9.92 99 732771 30533 109825896
Pneumatosis intestinalis 32.88 9.92 8 732862 8521 109847908
Klebsiella infection 32.87 9.92 51 732819 19958 109836471
Endometriosis 32.75 9.92 82 732788 4252 109852177
Psychomotor retardation 32.72 9.92 6 732864 7786 109848643
Arterial occlusive disease 32.58 9.92 193 732677 15115 109841314
Glaucoma 32.49 9.92 258 732612 22259 109834170
Pneumonia cytomegaloviral 32.31 9.92 4 732866 6950 109849479
Hyperpyrexia 32.24 9.92 7 732863 8062 109848367
Injection site urticaria 32.23 9.92 210 732660 17005 109839424
Micturition urgency 32.19 9.92 229 732641 19091 109837338
Platelet count decreased 32.14 9.92 1225 731645 229218 109627211
Weight fluctuation 32.10 9.92 254 732616 21891 109834538
Pathological fracture 31.87 9.92 161 732709 11871 109844558
Diffuse large B-cell lymphoma 31.79 9.92 35 732835 15863 109840566
Upper gastrointestinal haemorrhage 31.67 9.92 198 732672 49898 109806531
Calciphylaxis 31.41 9.92 79 732791 4108 109852321
Product prescribing error 31.36 9.92 205 732665 51126 109805303
Spinal operation 31.34 9.92 150 732720 10822 109845607
Sedation complication 31.31 9.92 52 732818 19803 109836626
Hyperammonaemia 31.20 9.92 27 732843 13705 109842724
Venoocclusive disease 31.16 9.92 3 732867 6347 109850082
X-ray abnormal 31.14 9.92 388 732482 37729 109818700
Leukoencephalopathy 31.11 9.92 11 732859 9184 109847245
Hypervitaminosis 30.97 9.92 13 732857 56 109856373
Drug dependence 30.95 9.92 199 732671 49821 109806608
Oesophageal carcinoma 30.94 9.92 19 732851 11505 109844924
Nocardiosis 30.94 9.92 6 732864 7480 109848949
Diffuse large B-cell lymphoma recurrent 30.85 9.92 3 732867 6296 109850133
Hypertonic bladder 30.74 9.92 91 732779 5211 109851218
Paraesthesia oral 30.70 9.92 350 732520 33321 109823108
Essential hypertension 30.70 9.92 118 732752 7729 109848700
Macular degeneration 30.62 9.92 247 732623 21412 109835017
Bradyphrenia 30.58 9.92 20 732850 11708 109844721
Atopy 30.57 9.92 38 732832 1116 109855313
Chest pain 30.56 9.92 2894 729976 373481 109482948
Cardiac failure chronic 30.36 9.92 28 732842 13783 109842646
Suicidal ideation 30.21 9.92 439 732431 93498 109762931
Acute pulmonary oedema 30.20 9.92 41 732829 16955 109839474
Injection site rash 29.88 9.92 261 732609 23158 109833271
Dry throat 29.88 9.92 131 732739 9107 109847322
Secondary progressive multiple sclerosis 29.87 9.92 44 732826 1525 109854904
Transplant dysfunction 29.87 9.92 9 732861 8319 109848110
Pemphigoid 29.81 9.92 53 732817 19654 109836775
Erysipelas 29.74 9.92 26 732844 13132 109843297
Toothache 29.70 9.92 262 732608 23313 109833116
Cytomegalovirus viraemia 29.45 9.92 45 732825 17719 109838710
Therapy cessation 29.43 9.92 439 732431 44418 109812011
Methaemoglobinaemia 29.29 9.92 12 732858 9156 109847273
Pulseless electrical activity 29.20 9.92 41 732829 16716 109839713
Gastrointestinal toxicity 29.08 9.92 19 732851 11129 109845300
Restlessness 28.92 9.92 236 732634 56023 109800406
Sputum purulent 28.86 9.92 48 732822 1850 109854579
Intestinal ischaemia 28.78 9.92 39 732831 16140 109840289
Myalgia 28.77 9.92 1774 731096 220607 109635822
Subdural haematoma 28.61 9.92 134 732736 36320 109820109
Drug hypersensitivity 28.52 9.92 3432 729438 450658 109405771
Colitis ischaemic 28.44 9.92 46 732824 17704 109838725
Pulmonary toxicity 28.43 9.92 46 732824 17700 109838729
Nervousness 28.36 9.92 371 732499 36480 109819949
Dysstasia 28.35 9.92 339 732531 32647 109823782
Persecutory delusion 28.32 9.92 4 732866 6287 109850142
Adjustment disorder with depressed mood 28.23 9.92 428 732442 43455 109812974
Bronchospasm 28.19 9.92 104 732766 30135 109826294
Delirium 28.17 9.92 680 732190 134345 109722084
Electrolyte imbalance 27.96 9.92 138 732732 36890 109819539
Cardiac failure congestive 27.90 9.92 774 732096 150226 109706203
Peripheral sensory neuropathy 27.90 9.92 42 732828 16638 109839791
Cardiovascular disorder 27.87 9.92 69 732801 22691 109833738
Urine odour abnormal 27.78 9.92 110 732760 7305 109849124
Tachyarrhythmia 27.75 9.92 10 732860 8251 109848178
Fracture displacement 27.62 9.92 41 732829 1431 109854998
Rhonchi 27.59 9.92 79 732791 4439 109851990
Blepharospasm 27.59 9.92 514 732356 54337 109802092
Purpura 27.53 9.92 77 732793 24311 109832118
Haemorrhage intracranial 27.42 9.92 99 732771 28870 109827559
Palpitations 27.12 9.92 1303 731567 157909 109698520
Pseudomonal sepsis 27.08 9.92 13 732857 9033 109847396
Hip arthroplasty 27.04 9.92 520 732350 55293 109801136
Hair texture abnormal 26.98 9.92 72 732798 3882 109852547
Angina unstable 26.88 9.92 42 732828 16390 109840039
Wrong product administered 26.84 9.92 20 732850 10940 109845489
Pericardial effusion 26.75 9.92 246 732624 56971 109799458
Graft versus host disease in gastrointestinal tract 26.67 9.92 13 732857 8955 109847474
Tooth extraction 26.51 9.92 162 732708 12829 109843600
Laboratory test abnormal 26.48 9.92 425 732445 43654 109812775
Unintentional medical device removal 26.44 9.92 13 732857 8910 109847519
Urine analysis abnormal 26.40 9.92 103 732767 6794 109849635
Sinus headache 26.35 9.92 94 732776 5938 109850491
Nicotine dependence 26.32 9.92 38 732832 1293 109855136
Candida infection 26.26 9.92 198 732672 47811 109808618
Lumbar vertebral fracture 26.20 9.92 125 732745 9006 109847423
Hypovolaemic shock 26.10 9.92 35 732835 14548 109841881
Hallucination 26.06 9.92 494 732376 100938 109755491
Acne 26.02 9.92 338 732532 33182 109823247
Hypoxia 26.00 9.92 656 732214 128859 109727570
Catatonia 25.94 9.92 22 732848 11278 109845151
Proteinuria 25.90 9.92 157 732713 39861 109816568
Cardiomyopathy 25.86 9.92 124 732746 33401 109823028
Finger deformity 25.82 9.92 334 732536 32758 109823671
Gastric cancer 25.80 9.92 21 732849 10987 109845442
Multiple allergies 25.71 9.92 154 732716 12109 109844320
Organising pneumonia 25.67 9.92 34 732836 14209 109842220
Back disorder 25.57 9.92 231 732639 20691 109835738
Gastrointestinal pain 25.55 9.92 150 732720 11710 109844719
Drug-induced liver injury 25.51 9.92 603 732267 119464 109736965
Diverticulitis 25.37 9.92 497 732373 53025 109803404
Cell death 25.33 9.92 4 732866 5787 109850642
Recalled product 25.33 9.92 33 732837 1017 109855412
Procedural pain 25.30 9.92 353 732517 35212 109821217
Pulmonary mass 25.24 9.92 367 732503 36934 109819495
Hypernatraemia 25.17 9.92 50 732820 17783 109838646
Nausea 25.14 9.92 8835 724035 1226855 108629574
Renal tubular necrosis 25.13 9.92 110 732760 30365 109826064
Visual impairment 25.02 9.92 1110 731760 133318 109723111
Total lung capacity abnormal 25.01 9.92 77 732793 4506 109851923
Product monitoring error 24.98 9.92 14 732856 8913 109847516
Hypersomnia 24.83 9.92 290 732580 27771 109828658
Chronic graft versus host disease 24.83 9.92 16 732854 9441 109846988
Obesity 24.76 9.92 952 731918 112399 109744030
Metabolic disorder 24.70 9.92 20 732850 10490 109845939
Psychomotor skills impaired 24.65 9.92 8 732862 7050 109849379
Muscle tightness 24.61 9.92 175 732695 14587 109841842
Central nervous system mass 24.60 9.92 29 732841 805 109855624
Colorectal cancer 24.51 9.92 15 732855 9099 109847330
Affect lability 24.45 9.92 209 732661 18428 109838001
Blood iron decreased 24.44 9.92 214 732656 19000 109837429
Acute graft versus host disease in intestine 24.43 9.92 4 732866 5635 109850794
Dermatitis exfoliative generalised 24.41 9.92 22 732848 10950 109845479
Immune-mediated enterocolitis 24.41 9.92 19 732851 10166 109846263
Amnesia 24.39 9.92 891 731979 104517 109751912
Nephrectomy 24.36 9.92 54 732816 2586 109853843
Feeling hot 24.33 9.92 783 732087 90323 109766106
Muscle rigidity 24.18 9.92 80 732790 23951 109832478
Eye infection 24.14 9.92 172 732698 14346 109842083
Hepatic cirrhosis 24.13 9.92 603 732267 67023 109789406
Thrombosis 24.06 9.92 914 731956 107748 109748681
Abnormal faeces 24.06 9.92 123 732747 9113 109847316
Metastases to lymph nodes 24.05 9.92 39 732831 14993 109841436
Cross sensitivity reaction 24.01 9.92 4 732866 5563 109850866
Pneumonia aspiration 23.95 9.92 386 732484 80847 109775582
Body temperature increased 23.92 9.92 502 732368 54211 109802218
Gastric haemorrhage 23.89 9.92 43 732827 15872 109840557
Staphylococcal sepsis 23.74 9.92 50 732820 17404 109839025
Thyroid disorder 23.71 9.92 193 732677 16776 109839653
Nodule 23.66 9.92 325 732545 32306 109824123
Coronary artery stenosis 23.64 9.92 34 732836 13724 109842705
Compression fracture 23.64 9.92 123 732747 9176 109847253
Injection site swelling 23.56 9.92 556 732314 61234 109795195
Vision blurred 23.49 9.92 1063 731807 127959 109728470
Pulmonary function test decreased 23.46 9.92 117 732753 8583 109847846
Musculoskeletal discomfort 23.45 9.92 249 732621 23289 109833140
Generalised oedema 23.44 9.92 114 732756 30590 109825839
Premature labour 23.43 9.92 16 732854 9156 109847273
Complications of transplanted kidney 23.36 9.92 10 732860 7432 109848997
Bursitis 23.35 9.92 1069 731801 128849 109727580
Hospice care 23.26 9.92 152 732718 12321 109844108
Cyst 23.25 9.92 188 732682 16308 109840121
Atrioventricular block 23.24 9.92 48 732822 16829 109839600
Hyperammonaemic encephalopathy 23.22 9.92 4 732866 5430 109850999
Swollen joint count increased 23.12 9.92 722 732148 82939 109773490
Chronic disease 23.08 9.92 16 732854 215 109856214
Tooth infection 23.07 9.92 237 732633 21979 109834450
Intraductal proliferative breast lesion 23.05 9.92 56 732814 2849 109853580
Cerebral haematoma 23.05 9.92 18 732852 9614 109846815
Joint swelling 23.01 9.92 3309 729561 439536 109416893
Bone cyst 22.98 9.92 64 732806 3539 109852890
Palmoplantar keratoderma 22.95 9.92 4 732866 5383 109851046
Pneumonia fungal 22.93 9.92 39 732831 14715 109841714
Drug screen positive 22.86 9.92 7 732863 6403 109850026
Activated partial thromboplastin time prolonged 22.83 9.92 74 732796 22294 109834135
Wall motion score index abnormal 22.77 9.92 28 732842 813 109855616
Rib fracture 22.75 9.92 332 732538 33438 109822991
Drug withdrawal syndrome 22.73 9.92 153 732717 37901 109818528
Viral infection 22.73 9.92 486 732384 52653 109803776
Hepatic enzyme abnormal 22.69 9.92 126 732744 9637 109846792
Osteomalacia 22.63 9.92 39 732831 1548 109854881
Laryngitis 22.58 9.92 401 732469 42010 109814419
Eye irritation 22.58 9.92 329 732541 33123 109823306
Meralgia paraesthetica 22.56 9.92 24 732846 593 109855836
Facet joint syndrome 22.53 9.92 819 732051 96009 109760420
Upper-airway cough syndrome 22.51 9.92 181 732689 15676 109840753
Asthma-chronic obstructive pulmonary disease overlap syndrome 22.49 9.92 7 732863 6337 109850092
Immune-mediated lung disease 22.45 9.92 4 732866 5299 109851130
Hypercalciuria 22.39 9.92 23 732847 545 109855884
Nervous system disorder 22.39 9.92 121 732749 31600 109824829
Cardiomegaly 22.32 9.92 108 732762 29022 109827407
Metastases to central nervous system 22.25 9.92 77 732793 22740 109833689
Rash pruritic 22.22 9.92 827 732043 97242 109759187
Hypoacusis 22.16 9.92 342 732528 34849 109821580
Femur fracture 22.12 9.92 416 732454 44053 109812376
Chronic sinusitis 22.09 9.92 259 732611 24825 109831604
Invasive ductal breast carcinoma 22.07 9.92 95 732775 6551 109849878
Hepatitis B reactivation 22.03 9.92 11 732859 7473 109848956
Nephrotic syndrome 22.02 9.92 36 732834 13795 109842634
Parathyroid tumour benign 21.93 9.92 31 732839 1034 109855395
Brain herniation 21.93 9.92 16 732854 8847 109847582
Tooth fracture 21.90 9.92 156 732714 13011 109843418
Crying 21.86 9.92 263 732607 25365 109831064
Abortion induced 21.84 9.92 13 732857 8006 109848423
Gangrene 21.84 9.92 184 732686 16157 109840272
Therapeutic response unexpected 21.81 9.92 248 732622 23595 109832834
Torus fracture 21.74 9.92 13 732857 133 109856296
Device use error 21.73 9.92 17 732853 9072 109847357
Tuberculosis 21.68 9.92 54 732816 17720 109838709
Grip strength decreased 21.66 9.92 690 732180 79484 109776945
Hypertransaminasaemia 21.59 9.92 85 732785 24170 109832259
Dissociation 21.58 9.92 20 732850 9822 109846607
Disseminated tuberculosis 21.53 9.92 4 732866 5142 109851287
Pancreatitis necrotising 21.52 9.92 5 732865 5496 109850933
Bladder cancer 21.50 9.92 66 732804 20226 109836203
Large intestine perforation 21.49 9.92 49 732821 16580 109839849
Brain abscess 21.43 9.92 9 732861 6765 109849664
Cardiac tamponade 21.41 9.92 26 732844 11281 109845148
Abnormal behaviour 21.35 9.92 161 732709 38878 109817551
Retroperitoneal haematoma 21.32 9.92 7 732863 6124 109850305
Mucous stools 21.32 9.92 96 732774 6751 109849678
Renal disorder 21.32 9.92 453 732417 49026 109807403
Blood urea increased 21.30 9.92 247 732623 54710 109801719
Obstruction 21.29 9.92 85 732785 5667 109850762
Intracranial pressure increased 21.28 9.92 23 732847 10512 109845917
Fractional exhaled nitric oxide increased 21.28 9.92 26 732844 750 109855679
Walking aid user 21.24 9.92 257 732613 24818 109831611
Cytomegalovirus test positive 21.23 9.92 10 732860 7026 109849403
Leukocytosis 21.22 9.92 241 732629 53587 109802842
Kidney transplant rejection 21.22 9.92 29 732841 11958 109844471
Vasoplegia syndrome 21.17 9.92 5 732865 5434 109850995
Defaecation urgency 21.07 9.92 114 732756 8633 109847796
Product administration error 21.07 9.92 152 732718 37065 109819364
Type I hypersensitivity 21.03 9.92 8 732862 6385 109850044
Foreign body in reproductive tract 21.03 9.92 29 732841 945 109855484
Systemic candida 21.02 9.92 21 732849 9953 109846476
Blood lactic acid increased 20.95 9.92 46 732824 15775 109840654
Rash erythematous 20.88 9.92 399 732471 81433 109774996
Ingrowing nail 20.86 9.92 58 732812 3204 109853225
Head discomfort 20.84 9.92 205 732665 18795 109837634
Blood calcium abnormal 20.82 9.92 40 732830 1729 109854700
Nephritic syndrome 20.81 9.92 21 732849 487 109855942
Milk-alkali syndrome 20.79 9.92 43 732827 1962 109854467
Accidental death 20.73 9.92 4 732866 5005 109851424
Pancreatic neuroendocrine tumour 20.71 9.92 28 732842 895 109855534
Ventricular dysfunction 20.71 9.92 12 732858 7499 109848930
Pulmonary embolism 20.69 9.92 1186 731684 213288 109643141
Tooth disorder 20.63 9.92 292 732578 29217 109827212
Hypertriglyceridaemia 20.55 9.92 48 732822 16106 109840323
Increased tendency to bruise 20.55 9.92 141 732729 11617 109844812
Arteriospasm coronary 20.54 9.92 18 732852 9082 109847347
Blood creatinine increased 20.54 9.92 996 731874 181893 109674536
Faeces soft 20.53 9.92 136 732734 11074 109845355
Mental status changes 20.40 9.92 368 732502 75754 109780675
Hyperprolactinaemia 20.38 9.92 9 732861 6566 109849863
Brain death 20.37 9.92 9 732861 6564 109849865
Live birth 20.37 9.92 604 732266 68880 109787549
Paradoxical drug reaction 20.31 9.92 21 732849 9796 109846633
Isosthenuria 20.30 9.92 12 732858 120 109856309
Airway remodelling 20.27 9.92 28 732842 914 109855515
Injury 20.20 9.92 1399 731471 175866 109680563
Kounis syndrome 20.19 9.92 7 732863 5918 109850511
Motor dysfunction 20.18 9.92 249 732621 24157 109832272
Appetite disorder 20.05 9.92 122 732748 9647 109846782
Liver injury 20.03 9.92 1203 731667 149210 109707219
Refusal of treatment by patient 20.00 9.92 20 732850 9474 109846955
Mean cell haemoglobin increased 19.99 9.92 82 732788 5535 109850894
Eye pain 19.78 9.92 453 732417 49646 109806783
Atrial tachycardia 19.72 9.92 19 732851 9159 109847270
Second primary malignancy 19.70 9.92 58 732812 18010 109838419
Conjunctival hyperaemia 19.68 9.92 7 732863 5824 109850605
Electrocardiogram ST segment elevation 19.64 9.92 19 732851 9141 109847288
Immune-mediated hepatic disorder 19.63 9.92 3 732867 4447 109851982
Intentional product use issue 19.63 9.92 1903 730967 246003 109610426
Insurance issue 19.59 9.92 129 732741 10483 109845946
Cytopenia 19.57 9.92 118 732752 29998 109826431
Mean cell haemoglobin concentration abnormal 19.53 9.92 14 732856 199 109856230
Medication error 19.48 9.92 540 732330 104826 109751603
Acute myeloid leukaemia recurrent 19.46 9.92 5 732865 5134 109851295
Swollen tongue 19.44 9.92 282 732588 60080 109796349
Cardiac septal defect 19.39 9.92 28 732842 953 109855476
Limb injury 19.39 9.92 354 732516 37282 109819147
Pleural thickening 19.38 9.92 58 732812 3341 109853088
Hypoxic-ischaemic encephalopathy 19.37 9.92 18 732852 8829 109847600
Oesophageal candidiasis 19.33 9.92 29 732841 11505 109844924
Immune thrombocytopenia 19.28 9.92 80 732790 22414 109834015
Chest discomfort 19.28 9.92 1369 731501 172479 109683950
Duodenal ulcer haemorrhage 19.26 9.92 15 732855 8022 109848407
Systemic infection 19.21 9.92 22 732848 9797 109846632
Dental implantation 19.20 9.92 24 732846 709 109855720
Anti-neutrophil cytoplasmic antibody positive vasculitis 19.17 9.92 6 732864 5411 109851018
Laryngeal oedema 19.16 9.92 22 732848 9785 109846644
Pain in jaw 19.06 9.92 459 732411 50718 109805711
Blood pressure diastolic abnormal 19.04 9.92 97 732773 25718 109830711
Renal injury 19.03 9.92 62 732808 18651 109837778
Collagen-vascular disease 19.00 9.92 10 732860 78 109856351
Hyperparathyroidism 18.95 9.92 62 732808 3748 109852681
Duodenal ulcer 18.93 9.92 66 732804 19448 109836981
Dislocation of vertebra 18.74 9.92 400 732470 43321 109813108
Ageusia 18.73 9.92 206 732664 19439 109836990
Bone marrow oedema 18.67 9.92 43 732827 2113 109854316
Amylase increased 18.64 9.92 34 732836 12485 109843944
Pneumothorax 18.60 9.92 147 732723 35138 109821291
Hepatitis toxic 18.52 9.92 8 732862 5913 109850516
Hepatomegaly 18.45 9.92 76 732794 21338 109835091
Tonsillar ulcer 18.44 9.92 19 732851 452 109855977
Device related infection 18.44 9.92 170 732700 39349 109817080
C-reactive protein 18.43 9.92 293 732577 30038 109826391
Escherichia infection 18.42 9.92 88 732782 23728 109832701
Cervix neoplasm 18.42 9.92 13 732857 180 109856249
Blood 25-hydroxycholecalciferol increased 18.32 9.92 6 732864 10 109856419
Bradyarrhythmia 18.31 9.92 5 732865 4929 109851500
Ventricular arrhythmia 18.26 9.92 24 732846 10063 109846366
Short-bowel syndrome 18.12 9.92 24 732846 752 109855677
Tibia fracture 18.07 9.92 89 732781 6496 109849933
Pericardial haemorrhage 18.07 9.92 6 732864 5211 109851218
Metastases to liver 17.93 9.92 149 732721 35237 109821192
Ankylosing spondylitis 17.89 9.92 170 732700 15442 109840987
Bacteraemia 17.82 9.92 187 732683 42203 109814226
Foot deformity 17.81 9.92 434 732436 48046 109808383
Bone giant cell tumour benign 17.79 9.92 5 732865 3 109856426
Plantar fasciitis 17.78 9.92 74 732796 5027 109851402
Nephrocalcinosis 17.76 9.92 38 732832 1776 109854653
High turnover osteopathy 17.71 9.92 10 732860 91 109856338
Lymphocyte percentage decreased 17.71 9.92 76 732794 5234 109851195
Psychiatric decompensation 17.70 9.92 8 732862 5757 109850672
Periorbital oedema 17.70 9.92 25 732845 10167 109846262
Retinitis 17.69 9.92 307 732563 32020 109824409
Pseudomonas infection 17.65 9.92 110 732760 27743 109828686
Viraemia 17.57 9.92 3 732867 4099 109852330
Hyperparathyroidism secondary 17.55 9.92 55 732815 3249 109853180
Paronychia 17.49 9.92 29 732841 11052 109845377
Anosognosia 17.41 9.92 3 732867 4071 109852358
Blood magnesium decreased 17.40 9.92 206 732664 19790 109836639
Cholangitis 17.40 9.92 53 732817 16282 109840147
Depressed mood 17.39 9.92 527 732343 60282 109796147
Hyperthyroidism 17.30 9.92 118 732752 29143 109827286
Hyperhidrosis 17.30 9.92 1040 731830 186258 109670171
Knee arthroplasty 17.29 9.92 558 732312 64390 109792039
Hepatitis B 17.27 9.92 23 732847 9589 109846840
Laryngeal pain 17.26 9.92 9 732861 5966 109850463
Cataract operation 17.22 9.92 81 732789 5802 109850627
Sensitive skin 17.22 9.92 59 732811 3653 109852776
Pneumocystis jirovecii infection 17.21 9.92 4 732866 4396 109852033
Clostridium difficile infection 17.19 9.92 460 732410 51669 109804760
Brain injury 17.18 9.92 40 732830 13436 109842993
Faecal calprotectin increased 17.17 9.92 89 732781 6630 109849799
Onychomadesis 17.14 9.92 410 732460 45253 109811176
Ventricular hypertrophy 17.07 9.92 13 732857 7032 109849397
Dyskinesia 17.04 9.92 239 732631 51207 109805222
Intervertebral disc protrusion 16.99 9.92 268 732602 27430 109828999
Product dose omission in error 16.98 9.92 234 732636 23278 109833151
Breast pain 16.93 9.92 119 732751 9881 109846548
Lung consolidation 16.93 9.92 27 732843 10449 109845980
Arthropod bite 16.92 9.92 116 732754 9555 109846874
Normochromic normocytic anaemia 16.91 9.92 146 732724 12911 109843518
Blood cholesterol abnormal 16.90 9.92 59 732811 3687 109852742
Immune-mediated myositis 16.89 9.92 10 732860 6176 109850253
Throat clearing 16.82 9.92 65 732805 4268 109852161
JC virus infection 16.78 9.92 7 732863 5283 109851146
Feeling jittery 16.71 9.92 160 732710 14562 109841867
Infusion site reaction 16.66 9.92 185 732685 17497 109838932
Virologic failure 16.62 9.92 6 732864 4946 109851483
Blood culture positive 16.62 9.92 21 732849 8955 109847474
Cryptococcosis 16.62 9.92 5 732865 4626 109851803
Inhibitory drug interaction 16.60 9.92 6 732864 4941 109851488
Wrong patient received product 16.58 9.92 12 732858 6662 109849767
Flushing 16.55 9.92 851 732019 103885 109752544
Oral discomfort 16.54 9.92 130 732740 11181 109845248
Duodenitis 16.53 9.92 22 732848 9174 109847255
Upper respiratory tract infection 16.49 9.92 1045 731825 130283 109726146
Lung neoplasm malignant 16.48 9.92 144 732726 33698 109822731
Heart rate decreased 16.44 9.92 688 732182 82068 109774361
Expanded disability status scale score increased 16.42 9.92 25 732845 893 109855536
Hyperuricaemia 16.31 9.92 46 732824 14485 109841944
Azotaemia 16.29 9.92 26 732844 10059 109846370
Cardiac disorder 16.27 9.92 639 732231 75641 109780788
Haemorrhage 16.26 9.92 561 732309 106131 109750298
Cholecystectomy 16.23 9.92 125 732745 10684 109845745
Apnoea 16.20 9.92 42 732828 13597 109842832
Hepatic encephalopathy 16.19 9.92 115 732755 28141 109828288
Guillain-Barre syndrome 16.15 9.92 29 732841 10715 109845714
Peroneal nerve palsy 16.12 9.92 94 732776 7320 109849109
Diabetes insipidus 16.08 9.92 12 732858 6558 109849871
Paranoia 15.98 9.92 85 732785 22289 109834140
Systemic mycosis 15.97 9.92 3 732867 3826 109852603
Movement disorder 15.91 9.92 334 732536 36070 109820359
Product distribution issue 15.90 9.92 64 732806 4282 109852147
Onychoclasis 15.89 9.92 92 732778 7145 109849284
Open reduction of fracture 15.89 9.92 14 732856 272 109856157
Bladder operation 15.88 9.92 27 732843 1060 109855369
Trichorrhexis 15.87 9.92 25 732845 920 109855509
Pruritus genital 15.85 9.92 12 732858 6510 109849919
Gastric ulcer 15.82 9.92 178 732692 39649 109816780
Areflexia 15.76 9.92 13 732857 6756 109849673
Electrocardiogram PR shortened 15.75 9.92 16 732854 374 109856055
Hyperreflexia 15.75 9.92 24 732846 9461 109846968
Vascular malformation 15.75 9.92 23 732847 791 109855638
Hypoproteinaemia 15.69 9.92 10 732860 5935 109850494
Right ventricular failure 15.68 9.92 104 732766 25850 109830579
Prerenal failure 15.67 9.92 5 732865 4454 109851975
Red cell distribution width increased 15.61 9.92 182 732688 17420 109839009
Grip strength 15.61 9.92 109 732761 9032 109847397
Duodenal ulcer perforation 15.56 9.92 1374 731496 176326 109680103
Alveolitis 15.56 9.92 5 732865 4434 109851995
Secondary adrenocortical insufficiency 15.53 9.92 5 732865 4429 109852000
Bone erosion 15.52 9.92 410 732460 45961 109810468
Therapeutic response shortened 15.50 9.92 279 732591 29304 109827125
Mouth ulceration 15.46 9.92 225 732645 47913 109808516
Viral mutation identified 15.45 9.92 5 732865 4414 109852015
Hypotonia 15.44 9.92 53 732817 15692 109840737
Frustration tolerance decreased 15.44 9.92 105 732765 8626 109847803
Device difficult to use 15.43 9.92 68 732802 18737 109837692
Gastrointestinal perforation 15.37 9.92 16 732854 7440 109848989
Rhinitis allergic 15.32 9.92 184 732686 17738 109838691
Paranasal cyst 15.30 9.92 24 732846 880 109855549
Linear IgA disease 15.28 9.92 5 732865 4384 109852045
Priapism 15.27 9.92 10 732860 5851 109850578
Atypical fracture 15.20 9.92 26 732844 1026 109855403
Dermatitis acneiform 15.15 9.92 39 732831 12656 109843773
Menopause 15.13 9.92 44 732826 2494 109853935
Haemolysis 15.10 9.92 53 732817 15586 109840843
Ventricular extrasystoles 15.09 9.92 88 732782 22553 109833876
Optic neuropathy 15.04 9.92 6 732864 4652 109851777
Carbohydrate antigen 125 increased 15.04 9.92 44 732826 2503 109853926
Hepatitis 15.03 9.92 468 732402 89586 109766843
Tumour haemorrhage 15.01 9.92 8 732862 5237 109851192
Acute lymphocytic leukaemia recurrent 14.91 9.92 10 732860 5777 109850652
Salivary hypersecretion 14.91 9.92 62 732808 17359 109839070
Aortic dissection 14.90 9.92 7 732863 4926 109851503
Congestive hepatopathy 14.88 9.92 8 732862 5212 109851217
Lung disorder 14.83 9.92 1386 731484 178661 109677768
Monocyte percentage increased 14.78 9.92 41 732829 2262 109854167
Hypercholesterolaemia 14.75 9.92 740 732130 90097 109766332
Joint stiffness 14.74 9.92 565 732305 66678 109789751
Cytomegalovirus colitis 14.73 9.92 15 732855 7046 109849383
Hordeolum 14.73 9.92 68 732802 4833 109851596
Bronchial haemorrhage 14.68 9.92 30 732840 1357 109855072
Pneumonia pseudomonal 14.67 9.92 17 732853 7529 109848900
Stupor 14.62 9.92 20 732850 8245 109848184
Atrial fibrillation 14.62 9.92 1316 731554 228326 109628103
Creatinine renal clearance increased 14.58 9.92 55 732815 3570 109852859
Proctitis 14.56 9.92 174 732696 16753 109839676
Behaviour disorder 14.54 9.92 26 732844 9621 109846808
Confusional state 14.53 9.92 2811 730059 465869 109390560
Antipsychotic drug level increased 14.52 9.92 15 732855 7000 109849429
Epstein-Barr viraemia 14.52 9.92 3 732867 3576 109852853
Chills 14.51 9.92 1459 731411 189121 109667308
Premature baby 14.50 9.92 7 732863 4848 109851581
Hallucinations, mixed 14.43 9.92 22 732848 8671 109847758
Creatinine renal clearance decreased 14.43 9.92 85 732785 21730 109834699
Immediate post-injection reaction 14.43 9.92 16 732854 415 109856014
Fixed eruption 14.42 9.92 5 732865 4227 109852202
Anhedonia 14.42 9.92 53 732817 15375 109841054
Lipodystrophy acquired 14.33 9.92 6 732864 4518 109851911
Angina pectoris 14.32 9.92 309 732561 61986 109794443
Mania 14.31 9.92 80 732790 20716 109835713
Cardioactive drug level increased 14.28 9.92 4 732866 3878 109852551
Mass excision 14.22 9.92 15 732855 367 109856062
Child abuse 14.22 9.92 23 732847 866 109855563
Compartment syndrome 14.20 9.92 11 732859 5899 109850530
Sensation of foreign body 14.15 9.92 96 732774 7879 109848550
Hyperplastic cholecystopathy 14.15 9.92 12 732858 221 109856208
Presbyacusis 14.13 9.92 46 732824 2773 109853656
Spinal compression fracture 14.09 9.92 185 732685 18207 109838222
Ulcer haemorrhage 14.08 9.92 219 732651 22352 109834077
Right atrial hypertrophy 14.06 9.92 20 732850 671 109855758
Blood pressure systolic decreased 14.04 9.92 44 732826 13397 109843032
Pulse absent 14.01 9.92 34 732836 11258 109845171
Cachexia 14.00 9.92 42 732828 12963 109843466
Infusion site extravasation 13.99 9.92 128 732742 11506 109844923
Vaginal infection 13.98 9.92 85 732785 6719 109849710
Coordination abnormal 13.96 9.92 240 732630 24988 109831441
Device expulsion 13.93 9.92 134 732736 30757 109825672
Arterial haemorrhage 13.93 9.92 4 732866 3815 109852614
Nerve degeneration 13.93 9.92 13 732857 273 109856156
Cholestatic liver injury 13.93 9.92 17 732853 7359 109849070
Cervical vertebral fracture 13.92 9.92 64 732806 4541 109851888
Small intestinal obstruction 13.90 9.92 295 732575 31918 109824511
Varicella zoster virus infection 13.89 9.92 13 732857 6355 109850074
Long QT syndrome 13.87 9.92 16 732854 7102 109849327
Post procedural hypothyroidism 13.85 9.92 13 732857 275 109856154
Drug clearance decreased 13.83 9.92 5 732865 4117 109852312
Necrotising fasciitis 13.81 9.92 18 732852 7573 109848856
Withdrawal syndrome 13.78 9.92 137 732733 31243 109825186
Albumin globulin ratio increased 13.77 9.92 9 732861 109 109856320
Calcification of muscle 13.75 9.92 11 732859 186 109856243
Rotator cuff syndrome 13.74 9.92 171 732699 16623 109839806
Immune reconstitution inflammatory syndrome 13.73 9.92 58 732812 16168 109840261
Eustachian tube obstruction 13.70 9.92 8 732862 78 109856351
Liver function test increased 13.69 9.92 718 732152 87830 109768599
Hepatocellular carcinoma 13.69 9.92 28 732842 9852 109846577
Haemolytic uraemic syndrome 13.69 9.92 8 732862 4977 109851452
Drug effective for unapproved indication 13.68 9.92 48 732822 14119 109842310
Blood potassium decreased 13.66 9.92 462 732408 53652 109802777
Intestinal perforation 13.64 9.92 82 732788 20862 109835567
COVID-19 pneumonia 13.60 9.92 169 732701 36974 109819455
Graft versus host disease in skin 13.60 9.92 21 732849 8233 109848196
Anti-transglutaminase antibody increased 13.59 9.92 6 732864 30 109856399
Oncologic complication 13.58 9.92 16 732854 444 109855985
Hypertension 13.58 9.92 3687 729183 506397 109350032
Urine ketone body present 13.57 9.92 56 732814 3790 109852639
Injection site induration 13.57 9.92 125 732745 11258 109845171
Lip swelling 13.56 9.92 245 732625 50422 109806007
Enzyme level decreased 13.53 9.92 5 732865 14 109856415
Immune system disorder 13.53 9.92 143 732727 13358 109843071
Drug effect less than expected 13.52 9.92 89 732781 7231 109849198
Oesophageal discomfort 13.50 9.92 17 732853 506 109855923
Nystagmus 13.48 9.92 36 732834 11541 109844888
Drug dose omission by device 13.48 9.92 50 732820 14466 109841963
Band sensation 13.46 9.92 25 732845 1053 109855376
Nephrogenic systemic fibrosis 13.43 9.92 10 732860 5473 109850956
Ischaemic hepatitis 13.43 9.92 7 732863 4641 109851788
Diffuse alveolar damage 13.42 9.92 5 732865 4042 109852387
Adverse reaction 13.42 9.92 273 732597 29321 109827108
Renal artery stenosis 13.41 9.92 4 732866 3722 109852707
Concussion 13.40 9.92 126 732744 11412 109845017
Adverse event 13.33 9.92 864 732006 107945 109748484
Specific gravity urine increased 13.32 9.92 17 732853 513 109855916
Petechiae 13.31 9.92 95 732775 23222 109833207
Sciatic nerve injury 13.27 9.92 21 732849 776 109855653
Hyperexplexia 13.26 9.92 7 732863 55 109856374
Acute abdomen 13.26 9.92 3 732867 3358 109853071
Abdominal wall haematoma 13.23 9.92 11 732859 5694 109850735
Gingival pain 13.21 9.92 161 732709 15575 109840854
Amyloid related imaging abnormality-oedema/effusion 13.18 9.92 31 732839 1544 109854885
Blood urine present 13.18 9.92 230 732640 24015 109832414
Peripheral ischaemia 13.17 9.92 34 732836 11024 109845405
Congenital coronary artery malformation 13.17 9.92 9 732861 118 109856311
Substance-induced psychotic disorder 13.15 9.92 10 732860 5414 109851015
Exposure via skin contact 13.06 9.92 139 732731 13008 109843421
Carbohydrate antigen 15-3 increased 13.03 9.92 31 732839 1556 109854873
Paranasal sinus hypersecretion 12.98 9.92 63 732807 4571 109851858
Blood magnesium increased 12.97 9.92 55 732815 3768 109852661
Drug specific antibody present 12.93 9.92 98 732772 8336 109848093
Stridor 12.90 9.92 16 732854 6879 109849550
Transplant failure 12.90 9.92 11 732859 5624 109850805
Blister 12.90 9.92 1708 731162 225668 109630761
Gallbladder operation 12.87 9.92 40 732830 2353 109854076
Gastrointestinal necrosis 12.86 9.92 15 732855 6625 109849804
Pelvic fracture 12.85 9.92 147 732723 14007 109842422
Hypochloraemia 12.81 9.92 4 732866 3614 109852815
Nasal obstruction 12.80 9.92 50 732820 3300 109853129
Muscle haemorrhage 12.79 9.92 16 732854 6853 109849576
Meniscus injury 12.77 9.92 92 732778 7701 109848728
Eructation 12.76 9.92 146 732724 13911 109842518
Joint ankylosis 12.75 9.92 41 732829 2456 109853973
Eyelid disorder 12.75 9.92 40 732830 2365 109854064
Aspiration 12.71 9.92 135 732735 30398 109826031
Rash pustular 12.71 9.92 43 732827 12786 109843643
Cardiovascular somatic symptom disorder 12.70 9.92 6 732864 36 109856393
Heart rate irregular 12.64 9.92 307 732563 33967 109822462
Rubber sensitivity 12.62 9.92 40 732830 2378 109854051
Fungaemia 12.61 9.92 13 732857 6073 109850356
Ischaemic cardiomyopathy 12.61 9.92 21 732849 7990 109848439
Polyneuropathy idiopathic progressive 12.61 9.92 5 732865 18 109856411
Vascular pseudoaneurysm 12.58 9.92 6 732864 4184 109852245
Sputum culture positive 12.57 9.92 5 732865 3884 109852545
Sarcoidosis 12.57 9.92 42 732828 12537 109843892
Vertebral wedging 12.57 9.92 6 732864 37 109856392
Anal fissure 12.54 9.92 110 732760 9771 109846658
Decreased interest 12.53 9.92 65 732805 4843 109851586
Food allergy 12.53 9.92 79 732791 19869 109836560
Fear 12.52 9.92 96 732774 23097 109833332
Erythema 12.52 9.92 1716 731154 289731 109566698
Vestibular migraine 12.50 9.92 10 732860 169 109856260
Regurgitation 12.50 9.92 51 732819 3434 109852995
Enteritis 12.48 9.92 75 732795 19081 109837348
Foreign body in throat 12.46 9.92 24 732846 1039 109855390
Liver abscess 12.45 9.92 20 732850 7719 109848710
C-telopeptide increased 12.44 9.92 6 732864 38 109856391
Primary familial brain calcification 12.44 9.92 6 732864 38 109856391
Blood albumin abnormal 12.43 9.92 21 732849 820 109855609
Feeling cold 12.41 9.92 304 732566 33683 109822746
Lacunar infarction 12.39 9.92 14 732856 6272 109850157
Subacute cutaneous lupus erythematosus 12.38 9.92 9 732861 4985 109851444
Type IV hypersensitivity reaction 12.38 9.92 13 732857 6020 109850409
Pernicious anaemia 12.35 9.92 20 732850 754 109855675
Quadriparesis 12.31 9.92 8 732862 4699 109851730
Neutralising antibodies positive 12.30 9.92 14 732856 374 109856055
Eosinophilic oesophagitis 12.29 9.92 27 732843 1285 109855144
Neuralgia 12.26 9.92 414 732456 48064 109808365
Prescription drug used without a prescription 12.25 9.92 11 732859 5485 109850944
Skin atrophy 12.24 9.92 80 732790 6484 109849945
Hand fracture 12.24 9.92 94 732776 8028 109848401
Intentional underdose 12.22 9.92 41 732829 2511 109853918
Infusion related reaction 12.22 9.92 2282 730588 378880 109477549
Vanishing bile duct syndrome 12.16 9.92 3 732867 3165 109853264
Abdominoplasty 12.15 9.92 9 732861 135 109856294
Endodontic procedure 12.14 9.92 47 732823 3089 109853340
pH urine increased 12.13 9.92 15 732855 438 109855991
Neutrophilia 12.12 9.92 32 732838 10297 109846132
Skin warm 12.12 9.92 103 732767 9067 109847362
Prothrombin time prolonged 12.09 9.92 66 732804 17195 109839234
Faeces hard 12.09 9.92 58 732812 4188 109852241
Poor quality sleep 12.07 9.92 257 732613 27820 109828609
Musculoskeletal chest pain 12.07 9.92 263 732607 28584 109827845
Pulmonary congestion 12.06 9.92 139 732731 30827 109825602
Acute lung injury 12.06 9.92 3 732867 3148 109853281
Haematoma muscle 12.06 9.92 6 732864 4084 109852345
Hepatic cancer 12.03 9.92 36 732834 11120 109845309
Eosinophil percentage increased 12.03 9.92 30 732840 1552 109854877
Adverse drug reaction 12.00 9.92 833 732037 104726 109751703
Vaginal haematoma 11.99 9.92 9 732861 138 109856291
Subileus 11.98 9.92 15 732855 6422 109850007
Caesarean section 11.93 9.92 49 732821 13768 109842661
Bed bug infestation 11.93 9.92 7 732863 69 109856360
Sinus polyp degeneration 11.93 9.92 7 732863 69 109856360
Nasal ulcer 11.89 9.92 41 732829 2546 109853883
Thyroid mass 11.89 9.92 66 732804 5047 109851382
Bezoar 11.87 9.92 6 732864 4048 109852381
Product use in unapproved indication 11.86 9.92 2704 730166 444673 109411756
Ileal stenosis 11.84 9.92 48 732822 3222 109853207
Clonus 11.83 9.92 25 732845 8691 109847738
Pneumonia bacterial 11.81 9.92 114 732756 26147 109830282
Hyperparathyroidism primary 11.80 9.92 16 732854 513 109855916
Mitral valve incompetence 11.70 9.92 153 732717 33176 109823253
Pneumonia 11.70 9.92 6181 726689 870533 108985896
Nail bed disorder 11.70 9.92 13 732857 338 109856091
Sleep terror 11.69 9.92 16 732854 6594 109849835
Colitis microscopic 11.66 9.92 138 732732 13256 109843173
Nerve compression 11.65 9.92 119 732751 11018 109845411
Joint dislocation 11.65 9.92 303 732567 33887 109822542
Nasal discharge discolouration 11.60 9.92 47 732823 3154 109853275
Heart rate abnormal 11.60 9.92 85 732785 7153 109849276
Product use issue 11.60 9.92 2288 730582 309407 109547022
Anaphylactoid reaction 11.60 9.92 17 732853 6809 109849620
Faecaloma 11.58 9.92 55 732815 14853 109841576
Bacterial infection 11.58 9.92 225 732645 45811 109810618
Bundle branch block left 11.57 9.92 45 732825 12843 109843586
Post procedural stroke 11.57 9.92 8 732862 107 109856322
Potentiating drug interaction 11.55 9.92 39 732831 11604 109844825
Mycobacterium chelonae infection 11.55 9.92 3 732867 3057 109853372
Unintended pregnancy 11.49 9.92 9 732861 4799 109851630
Endocrine ophthalmopathy 11.47 9.92 27 732843 1346 109855083
Intestinal resection 11.43 9.92 54 732816 3875 109852554
Appendicolith 11.42 9.92 52 732818 14203 109842226
Disturbance in social behaviour 11.42 9.92 10 732860 5048 109851381
Cerebellar syndrome 11.40 9.92 15 732855 6287 109850142
Psychomotor hyperactivity 11.39 9.92 83 732787 20194 109836235
Osteoporosis postmenopausal 11.38 9.92 6 732864 47 109856382
Intestinal pseudo-obstruction 11.38 9.92 4 732866 3352 109853077
Pneumomediastinum 11.32 9.92 10 732860 5026 109851403
Bone hypertrophy 11.32 9.92 19 732851 738 109855691
Loss of employment 11.31 9.92 4 732866 3340 109853089
Periarthritis 11.28 9.92 54 732816 3896 109852533
Exercise tolerance decreased 11.26 9.92 126 732744 11941 109844488
Renal tubular disorder 11.22 9.92 20 732850 7409 109849020
Drug delivery device placement 11.20 9.92 10 732860 198 109856231
Intraventricular haemorrhage 11.15 9.92 12 732858 5495 109850934
Neutrophil percentage increased 11.15 9.92 63 732807 4850 109851579
Papilloedema 11.14 9.92 20 732850 7389 109849040
Sexual dysfunction 11.13 9.92 25 732845 8505 109847924
Fibula fracture 11.13 9.92 60 732810 4538 109851891
Eyelid margin crusting 11.12 9.92 34 732836 1982 109854447
Colon operation 11.11 9.92 16 732854 543 109855886
Acute psychosis 11.10 9.92 10 732860 4977 109851452
Bronchial disorder 11.07 9.92 42 732828 2734 109853695
Inflammatory bowel disease 11.05 9.92 84 732786 7150 109849279
Swollen joint count decreased 11.05 9.92 13 732857 360 109856069
Cerebral ischaemia 11.04 9.92 42 732828 12062 109844367
Feeding disorder 11.03 9.92 201 732669 21161 109835268
Hepatosplenomegaly 11.02 9.92 18 732852 6901 109849528
Tenosynovitis 11.01 9.92 63 732807 16220 109840209
Lip oedema 11.00 9.92 21 732849 7579 109848850
Supraventricular tachycardia 10.99 9.92 106 732764 24316 109832113
Bacterial sepsis 10.98 9.92 34 732836 10392 109846037
Gastrointestinal stoma output increased 10.96 9.92 22 732848 982 109855447
Galactorrhoea 10.95 9.92 7 732863 4148 109852281
Polyneuropathy in malignant disease 10.94 9.92 15 732855 486 109855943
Cerebellar haemorrhage 10.92 9.92 4 732866 3267 109853162
Central obesity 10.92 9.92 34 732836 2002 109854427
Head banging 10.92 9.92 16 732854 552 109855877
Pancreatic carcinoma 10.90 9.92 56 732814 14816 109841613
Mycobacterial infection 10.89 9.92 8 732862 4409 109852020
Apathy 10.89 9.92 63 732807 16176 109840253
Urine albumin/creatinine ratio 10.87 9.92 5 732865 28 109856401
Withdrawal of life support 10.84 9.92 7 732863 83 109856346
Staphylococcal infection 10.84 9.92 367 732503 69577 109786852
Ototoxicity 10.83 9.92 7 732863 4124 109852305
Anti-cyclic citrullinated peptide antibody positive 10.82 9.92 1371 731499 180613 109675816
Diabetes mellitus 10.81 9.92 543 732327 98838 109757591
Neutrophil count increased 10.77 9.92 163 732707 34489 109821940
Retinal haemorrhage 10.72 9.92 30 732840 9471 109846958
Chorea 10.72 9.92 4 732866 3231 109853198
Gastroenteritis viral 10.72 9.92 277 732593 30949 109825480
Bladder disorder 10.71 9.92 117 732753 11020 109845409
Gastritis erosive 10.71 9.92 42 732828 11958 109844471
Depressive symptom 10.71 9.92 25 732845 8389 109848040
Pseudomonal bacteraemia 10.67 9.92 8 732862 4363 109852066
Carcinoembryonic antigen increased 10.67 9.92 42 732828 2782 109853647
Cyclic vomiting syndrome 10.65 9.92 9 732861 165 109856264
N-terminal prohormone brain natriuretic peptide increased 10.64 9.92 15 732855 6106 109850323
Foetal exposure during pregnancy 10.63 9.92 21 732849 7484 109848945
Rash morbilliform 10.63 9.92 23 732847 7928 109848501
Malabsorption 10.61 9.92 76 732794 6349 109850080
Lower respiratory tract infection viral 10.61 9.92 27 732843 1414 109855015
Epidural lipomatosis 10.61 9.92 34 732836 2033 109854396
Melanocytic naevus 10.60 9.92 69 732801 5585 109850844
Hepatitis C 10.60 9.92 45 732825 12528 109843901
Product complaint 10.59 9.92 52 732818 13920 109842509
Eye contusion 10.59 9.92 43 732827 2889 109853540
Gastric ulcer haemorrhage 10.58 9.92 33 732837 10061 109846368
Metastases to meninges 10.58 9.92 11 732859 5117 109851312
Product label confusion 10.55 9.92 210 732660 22467 109833962
Suicidal behaviour 10.51 9.92 5 732865 3492 109852937
Blood creatinine abnormal 10.50 9.92 71 732799 5821 109850608
Neoplasm of appendix 10.50 9.92 6 732864 56 109856373
Hepatorenal syndrome 10.49 9.92 9 732861 4588 109851841
Muscle strain 10.46 9.92 117 732753 11085 109845344
Red blood cell count increased 10.46 9.92 62 732808 4856 109851573
Cardiopulmonary failure 10.45 9.92 23 732847 7880 109848549
White blood cell count abnormal 10.43 9.92 80 732790 6829 109849600
Granulocytopenia 10.42 9.92 46 732824 12669 109843760
Intra-abdominal haemorrhage 10.42 9.92 12 732858 5330 109851099
Gingival recession 10.40 9.92 28 732842 1518 109854911
Gastritis haemorrhagic 10.39 9.92 4 732866 3169 109853260
Nightmare 10.37 9.92 188 732682 38675 109817754
Injection site hypersensitivity 10.37 9.92 38 732832 2433 109853996
Hungry bone syndrome 10.35 9.92 12 732858 327 109856102
Inadequate analgesia 10.35 9.92 11 732859 5066 109851363
Disability 10.34 9.92 268 732602 29955 109826474
Neurological symptom 10.34 9.92 153 732717 15455 109840974
Tympanosclerosis 10.32 9.92 6 732864 58 109856371
Osteosclerosis 10.31 9.92 58 732812 4457 109851972
Chronic left ventricular failure 10.30 9.92 25 732845 1271 109855158
Endometrial hypertrophy 10.30 9.92 9 732861 173 109856256
Blood pressure systolic abnormal 10.29 9.92 110 732760 24740 109831689
Nonspecific reaction 10.25 9.92 44 732826 3030 109853399
Venous thrombosis 10.25 9.92 26 732844 8479 109847950
Anticholinergic syndrome 10.24 9.92 8 732862 4272 109852157
Skin fissures 10.24 9.92 223 732647 24235 109832194
Cerebral toxoplasmosis 10.22 9.92 4 732866 3138 109853291
Upper motor neurone lesion 10.21 9.92 12 732858 332 109856097
Vitamin D abnormal 10.19 9.92 10 732860 224 109856205
Porphyria acute 10.15 9.92 178 732692 18602 109837827
Personality change 10.15 9.92 38 732832 10964 109845465
Temperature intolerance 10.14 9.92 139 732731 13811 109842618
Full blood count increased 10.14 9.92 18 732852 732 109855697
Hysterectomy 10.13 9.92 90 732780 8024 109848405
Blood alkaline phosphatase increased 10.12 9.92 376 732494 70559 109785870
General physical condition abnormal 10.11 9.92 22 732848 7568 109848861
Facial paralysis 10.11 9.92 107 732763 24107 109832322
Folliculitis 10.09 9.92 1264 731606 166389 109690040
Vaginal flatulence 10.08 9.92 124 732746 12020 109844409
Lymphocyte count decreased 10.07 9.92 470 732400 56773 109799656
Breast disorder 10.06 9.92 36 732834 2278 109854151
Ischaemia 10.02 9.92 29 732841 9054 109847375
Jaw disorder 10.01 9.92 64 732806 5148 109851281
Immunosuppressant drug therapy 10.01 9.92 3 732867 3 109856426
Platybasia 10.01 9.92 3 732867 3 109856426
Mastoiditis 10.00 9.92 39 732831 2572 109853857
Ear disorder 10.00 9.92 61 732809 4828 109851601
Spinal cord injury lumbar 9.98 9.92 6 732864 62 109856367
Renal infarct 9.98 9.92 5 732865 3390 109853039
Gastrointestinal infection 9.96 9.92 139 732731 13866 109842563
Drug tolerance decreased 9.95 9.92 246 732624 27294 109829135
Root canal infection 9.95 9.92 14 732856 465 109855964

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CC01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
FDA CS M0007651 Ergocalciferols
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients
MeSH PA D050071 Bone Density Conservation Agents
FDA EPC N0000175909 Provitamin D2 Compound
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33288 rodenticide
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:50646 bone density conservation agent
CHEBI has role CHEBI:50733 nutraceutical
CHEBI has role CHEBI:50864 insulin-sensitizing drug
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:76924 plant metabolite

Related Drugs by ATC class:

A11CC Vitamin D and analogues 5 drugs
alfacalcidolcalcifediolcalcitriolcolecalciferoldihydrotachysterol

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteomalacia indication 4598005 DOID:10573
Hypocalcemia indication 5291005
Vitamin D deficiency indication 34713006
Hypoparathyroidism indication 36976004 DOID:11199
Rickets indication 41345002 DOID:10609
Osteoporosis indication 64859006 DOID:11476
Familial x-linked hypophosphatemic vitamin D refractory rickets indication 82236004
Vitamin deficiency indication 85670002
Postmenopausal osteoporosis indication 102447009
Prevention of dental caries indication 426482000
Vitamin Deficiency Prevention indication
Hyperparathyroidism Secondary to Chronic Renal Failure with Dialysis indication
Hypogonadal Osteoporosis in Males indication
Vitamin D Dependent Rickets indication
Glucocorticoid Induced Osteoporosis indication
Renal osteodystrophy off-label use 16726004 DOID:13068
Hyperparathyroidism Secondary to Chronic Renal Failure off-label use
Anticonvulsant-induced Osteomalacia off-label use
Gastritis contraindication 4556007 DOID:4029
Poisoning by digitalis glycoside contraindication 12876009
Constipation contraindication 14760008 DOID:2089
Esophagitis contraindication 16761005 DOID:11963
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Dental fluorosis contraindication 30265004
Ulcer of esophagus contraindication 30811009
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Atrial fibrillation contraindication 49436004 DOID:0060224
Vitamin E deficiency contraindication 54137008
Hyperlipidemia contraindication 55822004 DOID:1168
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Stricture of esophagus contraindication 63305008
Hypervitaminosis A contraindication 64559002 DOID:9972
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Fracture of femur contraindication 71620000
Hypercalciuria contraindication 71938000
Duodenitis contraindication 72007001 DOID:8643
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Neoplasm of endometrium contraindication 123844007 DOID:1380
Neoplasm of prostate contraindication 126906006 DOID:10283
Hb SS disease contraindication 127040003 DOID:10923
Bed-ridden contraindication 160685001
Acute peptic ulcer contraindication 196682000
Osteolysis contraindication 203522001
Disease of liver contraindication 235856003 DOID:409
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Malignant tumor of cervix contraindication 363354003 DOID:4362
Hemochromatosis contraindication 399187006 DOID:2352
Central nervous system depression contraindication 418072004
Aseptic necrosis of bone of jaw contraindication 441809006
Carcinoma of female breast contraindication 447782002
Malabsorption States contraindication
High Grade Dysplasia associated with Barrett's Esophagus contraindication
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication
Esophageal Obstruction contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST WOMBAT-PK CHEMBL
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Enzyme WOMBAT-PK
Vitamin D 25-hydroxylase Enzyme WOMBAT-PK

External reference:

IDSource
4017629 VUID
N0000146009 NUI
D00187 KEGG_DRUG
4017629 VANDF
4017649 VANDF
4021908 VANDF
C0014695 UMLSCUI
CHEBI:28934 CHEBI
D2V PDB_CHEM_ID
CHEMBL1536 ChEMBL_ID
DB00153 DRUGBANK_ID
5280793 PUBCHEM_CID
382 INN_ID
VS041H42XC UNII
DB11094 DRUGBANK_ID
11253 RXNORM
1067 MMSL
315714 MMSL
335232 MMSL
3554 MMSL
4671 MMSL
5688 MMSL
6150 MMSL
d03128 MMSL
001013 NDDF
11563006 SNOMEDCT_US
23433006 SNOMEDCT_US
30178006 SNOMEDCT_US
71516007 SNOMEDCT_US
D004872 MESH_DESCRIPTOR_UI
VS041H42XC INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 10544-527 CAPSULE 1.25 mg ORAL ANDA 19 sections
ERGOCALCIFEROL Human Prescription Drug Label 1 13668-757 CAPSULE 1.25 mg ORAL NDA 18 sections
DRISDOL HUMAN PRESCRIPTION DRUG LABEL 1 30698-493 CAPSULE, LIQUID FILLED 1.25 mg ORAL NDA 19 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 33261-730 CAPSULE 1.25 mg ORAL ANDA 19 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 42291-266 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 20 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 42794-006 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 19 sections
Ergocalciferol Capsules, HUMAN PRESCRIPTION DRUG LABEL 1 42806-547 CAPSULE 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 43063-711 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 43353-238 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 20 sections
VITAMIN D Human Prescription Drug Label 1 43353-828 CAPSULE 1.25 mg ORAL ANDA 19 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 50090-3201 CAPSULE 1.25 1 ORAL ANDA 15 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 50090-5844 CAPSULE 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 50090-5844 CAPSULE 1.25 mg ORAL ANDA 18 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 50268-297 CAPSULE 1.25 mg ORAL ANDA 15 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 51407-700 CAPSULE 1.25 mg ORAL ANDA 15 sections
Ergocalciferol Capsules, HUMAN PRESCRIPTION DRUG LABEL 1 51655-730 CAPSULE 1.25 mg ORAL ANDA 18 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 51655-774 CAPSULE 1.25 mg ORAL ANDA 15 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 53217-287 CAPSULE 1.25 mg ORAL ANDA 16 sections
Ergocalciferol Capsules, HUMAN PRESCRIPTION DRUG LABEL 1 53401-021 CAPSULE 1.25 mg ORAL ANDA 19 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 54868-5799 CAPSULE 1.25 mg ORAL ANDA 11 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 60760-152 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 18 sections
Vitamin D HUMAN PRESCRIPTION DRUG LABEL 1 61919-702 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 10 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 62135-439 CAPSULE 1.25 mg ORAL ANDA 12 sections
ERGOCALCIFEROL Human Prescription Drug Label 1 62332-464 CAPSULE 1.25 mg ORAL ANDA 18 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 63187-519 CAPSULE 1.25 mg ORAL ANDA 16 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 63629-2447 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 63629-7913 CAPSULE 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 64205-157 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 10 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 64380-737 CAPSULE 1.25 mg ORAL ANDA 15 sections
Vitalipid N HUMAN PRESCRIPTION DRUG LABEL 4 65219-335 EMULSION 20 [iU] INTRAVENOUS Unapproved drug for use in drug shortage 2 sections