alfacalcidol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 130 41294-56-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alfacalcidol
  • 1alpha-Hydroxycholecalciferol
  • alfarol
  • alphacalcidol
  • einsalpha
  • alpha-calcidol
  • 1-hydroxycholecalciferol
  • Molecular weight: 400.65
  • Formula: C27H44O2
  • CLOGP: 8.24
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -5.39
  • ROTB: 6

Drug dosage:

DoseUnitRoute
1 mcg O
1 mcg P
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.00 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 71 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance) 0.82 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 48.60 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,BRAF,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK,TGFBR1 16
kinase-selectivity-class GRK2 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1978 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Muscle spasticity 485.88 13.44 229 27004 35093 90566121
Body temperature increased 457.59 13.44 237 26996 44473 90556741
Ear pain 416.82 13.44 243 26990 57459 90543755
Respiratory disorder 400.85 13.44 247 26986 64569 90536645
Night sweats 294.23 13.44 270 26963 128496 90472718
Lower respiratory tract infection 170.39 13.44 285 26948 250374 90350840
Hypocalcaemia 162.16 13.44 120 27113 42248 90558966
Overlap syndrome 147.66 13.44 65 27168 8483 90592731
Back pain 138.93 13.44 299 26934 316876 90284338
Hypercalcaemia 124.37 13.44 94 27139 34146 90567068
Hepatic function abnormal 123.34 13.44 106 27127 46182 90555032
Insomnia 110.60 13.44 282 26951 333192 90268022
Urticaria 108.45 13.44 269 26964 312465 90288749
Drug ineffective 103.36 13.44 161 27072 1384137 89217077
Renal impairment 91.13 13.44 134 27099 105287 90495927
Upper respiratory tract inflammation 90.45 13.44 33 27200 2639 90598575
Shunt stenosis 90.33 13.44 23 27210 536 90600678
Sinusitis 87.81 13.44 264 26969 342824 90258390
Osteonecrosis of jaw 87.22 13.44 81 27152 39022 90562192
Abdominal pain upper 87.05 13.44 258 26975 332416 90268798
Spinal compression fracture 84.07 13.44 54 27179 15124 90586090
Peripheral swelling 67.49 13.44 274 26959 412832 90188382
Pruritus 67.28 13.44 331 26902 541194 90060020
Product dose omission issue 63.08 13.44 7 27226 291680 90309534
Asthenia 57.77 13.44 314 26919 533437 90067777
Vomiting 51.26 13.44 408 26825 787885 89813329
Blood parathyroid hormone increased 49.42 13.44 23 27210 3414 90597800
Joint swelling 48.44 13.44 287 26946 503013 90098201
Cerebral infarction 47.88 13.44 49 27184 26547 90574667
Incorrect route of product administration 47.59 13.44 67 27166 50559 90550655
Shunt occlusion 43.58 13.44 14 27219 761 90600453
Diarrhoea 43.17 13.44 451 26782 938739 89662475
Nausea 39.95 13.44 185 27048 1110131 89491083
Interstitial lung disease 39.19 13.44 77 27156 76328 90524886
Atypical femur fracture 38.44 13.44 24 27209 6397 90594817
Enteritis infectious 37.21 13.44 17 27216 2418 90598796
Fatigue 37.10 13.44 200 27033 1153823 89447391
Muscle injury 36.97 13.44 127 27106 176527 90424687
Milk-alkali syndrome 36.79 13.44 14 27219 1259 90599955
Folliculitis 33.65 13.44 136 27097 204217 90396997
Toxicity to various agents 33.10 13.44 23 27210 287823 90313391
Drug hypersensitivity 32.40 13.44 56 27177 463553 90137661
Immunosuppressant drug level increased 31.88 13.44 19 27214 4661 90596553
Ileus 30.72 13.44 31 27202 16515 90584699
Cardiac failure 30.55 13.44 87 27146 109409 90491805
Lymph node palpable 29.63 13.44 7 27226 118 90601096
Abdominal discomfort 29.55 13.44 62 27171 477266 90123948
Toxoplasmosis 28.98 13.44 13 27220 1772 90599442
Large intestine polyp 28.10 13.44 23 27210 9363 90591851
Hyperuricaemia 27.89 13.44 20 27213 6699 90594515
Rash 27.46 13.44 362 26871 795738 89805476
Injection site pain 27.41 13.44 9 27224 173690 90427524
Calciphylaxis 26.42 13.44 15 27218 3361 90597853
Gastrointestinal disorder 26.33 13.44 149 27084 256538 90344676
Iron deficiency anaemia 26.33 13.44 34 27199 23628 90577586
Impaired healing 26.07 13.44 139 27094 234060 90367154
Gastroenteritis 25.01 13.44 37 27196 29192 90572022
Nephrogenic anaemia 24.99 13.44 13 27220 2453 90598761
Platelet count decreased 24.84 13.44 94 27139 136875 90464339
Tetany 24.41 13.44 13 27220 2571 90598643
Pneumonia aspiration 24.40 13.44 44 27189 40896 90560318
Beta 2 microglobulin urine increased 23.76 13.44 5 27228 48 90601166
Marasmus 23.60 13.44 9 27224 814 90600400
Hyperhidrosis 23.46 13.44 6 27227 136299 90464915
Sleep disorder due to general medical condition, insomnia type 23.07 13.44 88 27145 128606 90472608
Headache 22.93 13.44 375 26858 862371 89738843
Therapeutic drug monitoring analysis incorrectly performed 22.67 13.44 7 27226 334 90600880
Disseminated intravascular coagulation 22.49 13.44 30 27203 21508 90579706
Enterocolitis viral 22.36 13.44 7 27226 350 90600864
Periodontitis 22.06 13.44 14 27219 3839 90597375
Oncocytoma 22.01 13.44 4 27229 16 90601198
Enterocolitis 21.98 13.44 21 27212 10469 90590745
Torticollis 21.75 13.44 12 27221 2546 90598668
Colon cancer 21.23 13.44 21 27212 10923 90590291
Haemodialysis complication 20.93 13.44 6 27227 221 90600993
Osteomyelitis 20.66 13.44 33 27200 27813 90573401
Depression 20.36 13.44 37 27196 300564 90300650
Drug intolerance 20.20 13.44 68 27165 447523 90153691
Chronic gastritis 19.95 13.44 13 27220 3728 90597486
Peritonitis 19.90 13.44 27 27206 19678 90581536
Death 19.50 13.44 71 27162 456480 90144734
Treatment failure 19.19 13.44 39 27194 303889 90297325
Vanishing bile duct syndrome 19.16 13.44 9 27224 1363 90599851
Parathyroid hyperplasia 18.83 13.44 5 27228 138 90601076
Puncture site erythema 18.79 13.44 3 27230 4 90601210
Hypotension 18.70 13.44 44 27189 325353 90275861
Pneumonia bacterial 18.51 13.44 21 27212 12769 90588445
Feeling abnormal 18.39 13.44 14 27219 167221 90433993
Plasmapheresis 18.32 13.44 6 27227 347 90600867
Anti-saccharomyces cerevisiae antibody test positive 17.63 13.44 4 27229 56 90601158
Oxalosis 17.50 13.44 4 27229 58 90601156
Peripheral arterial occlusive disease 17.47 13.44 13 27220 4608 90596606
Premature rupture of membranes 17.44 13.44 14 27219 5544 90595670
Alopecia 17.41 13.44 83 27150 494988 90106226
Renal transplant 17.39 13.44 9 27224 1679 90599535
Cough 17.37 13.44 55 27178 368907 90232307
Grip strength 17.02 13.44 17 27216 8948 90592266
Neuropsychiatric lupus 16.90 13.44 5 27228 206 90601008
Immobilisation syndrome 16.60 13.44 6 27227 467 90600747
Intentional overdose 16.40 13.44 4 27229 93830 90507384
Infusion related reaction 16.39 13.44 67 27166 416713 90184501
Hypoalbuminaemia 16.38 13.44 22 27211 15875 90585339
Community acquired infection 16.31 13.44 3 27230 13 90601201
Weight decreased 16.27 13.44 59 27174 379851 90221363
Skin erosion 16.22 13.44 11 27222 3371 90597843
Contusion 16.21 13.44 130 27103 251086 90350128
Haemorrhage subcutaneous 16.18 13.44 11 27222 3385 90597829
Shunt malfunction 16.15 13.44 4 27229 83 90601131
Injection site reaction 15.94 13.44 4 27229 92076 90509138
Blister 15.93 13.44 131 27102 254867 90346347
Heart rate increased 15.89 13.44 7 27226 112895 90488319
Arthropathy 15.60 13.44 57 27176 366185 90235029
Oesophageal mucosal tear 15.50 13.44 3 27230 18 90601196
Autoimmune pancytopenia 15.44 13.44 4 27229 100 90601114
Blood albumin decreased 15.44 13.44 22 27211 16781 90584433
Balance disorder 15.36 13.44 5 27228 97075 90504139
Hyperphosphataemia 15.30 13.44 11 27222 3700 90597514
Pemphigus 15.19 13.44 49 27184 326815 90274399
Femoral neck fracture 15.15 13.44 17 27216 10216 90590998
Heat illness 15.09 13.44 5 27228 300 90600914
Drug eruption 15.00 13.44 33 27200 35374 90565840
Precocious puberty 14.84 13.44 5 27228 316 90600898
Anxiety 14.70 13.44 46 27187 309726 90291488
Shunt infection 14.59 13.44 4 27229 125 90601089
Chills 14.57 13.44 11 27222 131970 90469244
Calculus urinary 14.53 13.44 8 27225 1690 90599524
Aortic dissection 14.38 13.44 9 27224 2408 90598806
Wound 14.37 13.44 45 27188 302935 90298279
Cholangitis 14.34 13.44 14 27219 7168 90594046
Mobility decreased 14.32 13.44 34 27199 250700 90350514
Lower limb fracture 14.31 13.44 57 27176 84956 90516258
Liver disorder 14.18 13.44 73 27160 121196 90480018
Hyperparathyroidism secondary 14.09 13.44 8 27225 1793 90599421
Anaemia 14.07 13.44 165 27068 352637 90248577
Aplasia pure red cell 14.04 13.44 12 27221 5182 90596032
Stag horn calculus 14.02 13.44 4 27229 145 90601069
Stomatitis 14.01 13.44 135 27098 274563 90326651
Gastrointestinal haemorrhage 14.00 13.44 59 27174 90189 90511025
Aortic valve stenosis 13.99 13.44 11 27222 4229 90596985
Nephrocalcinosis 13.95 13.44 7 27226 1225 90599989
Disease progression 13.82 13.44 16 27217 156599 90444615
Hungry bone syndrome 13.81 13.44 4 27229 153 90601061
Calcium metabolism disorder 13.78 13.44 4 27229 154 90601060
Vision blurred 13.78 13.44 8 27225 110285 90490929
Completed suicide 13.70 13.44 14 27219 145044 90456170
Neurosis 13.70 13.44 5 27228 400 90600814
Venous thrombosis limb 13.67 13.44 10 27223 3452 90597762
Pharyngitis 13.60 13.44 24 27209 21923 90579291
Therapeutic drug monitoring analysis not performed 13.45 13.44 7 27226 1322 90599892

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Shunt stenosis 153.80 16.57 36 10168 741 42610390
Hypocalcaemia 139.54 16.57 88 10116 30085 42581046
Immunosuppressant drug level increased 116.78 16.57 50 10154 7681 42603450
Oesophageal perforation 113.62 16.57 31 10173 1202 42609929
Soft tissue mass 110.05 16.57 29 10175 983 42610148
Shunt occlusion 109.62 16.57 29 10175 998 42610133
Multimorbidity 107.41 16.57 28 10176 909 42610222
Superinfection 79.47 16.57 29 10175 2922 42608209
Transplant failure 74.02 16.57 30 10174 4014 42607117
Renal impairment 68.09 16.57 106 10098 110122 42501009
Myocardial ischaemia 67.87 16.57 46 10158 17716 42593415
Oesophageal carcinoma 59.63 16.57 34 10170 9662 42601469
Hepatic function abnormal 58.82 16.57 67 10137 51500 42559631
Labelled drug-drug interaction medication error 58.69 16.57 40 10164 15542 42595589
Lung consolidation 56.68 16.57 29 10175 6648 42604483
Inflammatory marker increased 56.36 16.57 29 10175 6727 42604404
Drug ineffective 53.22 16.57 44 10160 630153 41980978
Rales 49.55 16.57 32 10172 11368 42599763
Osteonecrosis of jaw 49.32 16.57 39 10165 19010 42592121
Cardiomegaly 49.25 16.57 37 10167 16729 42594402
Hypercalcaemia 48.98 16.57 38 10166 18020 42593111
Drug interaction 46.63 16.57 155 10049 266844 42344287
Procalcitonin abnormal 46.22 16.57 12 10192 383 42610748
Upper respiratory tract inflammation 45.06 16.57 17 10187 1879 42609252
Aplasia pure red cell 43.72 16.57 25 10179 7141 42603990
Anti-erythropoietin antibody negative 43.32 16.57 10 10194 193 42610938
PCO2 decreased 38.74 16.57 15 10189 1779 42609352
Interstitial lung disease 38.38 16.57 68 10136 78394 42532737
Drug level increased 34.98 16.57 37 10167 26163 42584968
Encephalomalacia 34.52 16.57 12 10192 1049 42610082
Lower respiratory tract infection 33.22 16.57 45 10159 41161 42569970
Pleural effusion 30.49 16.57 70 10134 97096 42514035
Neuromyopathy 30.00 16.57 11 10193 1123 42610008
Calciphylaxis 29.63 16.57 11 10193 1162 42609969
PO2 decreased 29.43 16.57 12 10192 1629 42609502
Peripheral arterial occlusive disease 29.23 16.57 19 10185 6819 42604312
Pneumonia 28.26 16.57 185 10019 421964 42189167
Cerebral infarction 28.15 16.57 36 10168 31133 42579998
Prinzmetal angina 28.08 16.57 11 10193 1346 42609785
Hyperkalaemia 27.52 16.57 60 10144 80398 42530733
Dysphagia 25.75 16.57 55 10149 72664 42538467
Spinal compression fracture 25.34 16.57 18 10186 7465 42603666
Fatigue 25.21 16.57 41 10163 435600 42175531
Nephrotic syndrome 25.07 16.57 19 10185 8699 42602432
Ascites 25.01 16.57 47 10157 56631 42554500
Device related sepsis 24.89 16.57 14 10190 3873 42607258
Retinopathy hypertensive 24.68 16.57 7 10197 313 42610818
Acute kidney injury 23.96 16.57 160 10044 367177 42243954
C-reactive protein increased 23.57 16.57 49 10155 63511 42547620
Disseminated intravascular coagulation 22.96 16.57 29 10175 24765 42586366
Pyrexia 22.40 16.57 166 10038 393876 42217255
Hypoglycaemia 22.03 16.57 46 10158 59808 42551323
Lymphocyte count increased 21.68 16.57 13 10191 4051 42607080
International normalised ratio increased 21.32 16.57 40 10164 48128 42563003
Pain 20.66 16.57 17 10187 244831 42366300
Renal tubular acidosis 20.64 16.57 11 10193 2739 42608392
Haemoptysis 20.02 16.57 38 10166 46129 42565002
Monocyte count increased 19.98 16.57 14 10190 5680 42605451
Hepatosplenomegaly neonatal 19.77 16.57 4 10200 40 42611091
Abdominal wall haematoma 19.46 16.57 10 10194 2312 42608819
Bradycardia foetal 19.45 16.57 6 10198 360 42610771
Myeloperoxidase deficiency 19.42 16.57 4 10200 44 42611087
Pneumonia aspiration 19.03 16.57 39 10165 50039 42561092
Liver disorder 18.91 16.57 34 10170 39610 42571521
Organising pneumonia 18.59 16.57 15 10189 7517 42603614
Idiopathic interstitial pneumonia 18.37 16.57 6 10198 433 42610698
Extraskeletal ossification 18.15 16.57 4 10200 62 42611069
Pneumonia bacterial 17.21 16.57 20 10184 15672 42595459
Cardiac failure congestive 16.96 16.57 52 10152 85550 42525581
Product dose omission issue 16.76 16.57 8 10196 154357 42456774
Malaise 16.65 16.57 97 10107 212059 42399072

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypocalcaemia 268.89 12.23 197 34648 65169 110489285
Shunt stenosis 229.69 12.23 59 34786 1357 110553097
Muscle spasticity 206.26 12.23 133 34712 35782 110518672
Ear pain 186.95 12.23 146 34699 53080 110501374
Body temperature increased 181.26 12.23 145 34700 54568 110499886
Hepatic function abnormal 166.02 12.23 171 34674 89124 110465330
Hypercalcaemia 163.89 12.23 128 34717 46529 110507925
Respiratory disorder 159.26 12.23 151 34694 71231 110483223
Shunt occlusion 145.22 12.23 43 34802 1694 110552760
Overlap syndrome 144.21 12.23 66 34779 8993 110545461
Renal impairment 131.85 12.23 223 34622 188222 110366232
Osteonecrosis of jaw 129.48 12.23 113 34732 47904 110506550
Upper respiratory tract inflammation 127.43 12.23 49 34796 4322 110550132
Drug ineffective 123.20 12.23 181 34664 1520359 109034095
Night sweats 110.66 12.23 171 34674 133812 110420642
Spinal compression fracture 110.26 12.23 70 34775 18322 110536132
Immunosuppressant drug level increased 105.45 12.23 58 34787 11666 110542788
Oesophageal perforation 100.20 12.23 32 34813 1627 110552827
Lower respiratory tract infection 98.72 12.23 229 34616 242877 110311577
Soft tissue mass 86.17 12.23 28 34817 1505 110552949
Multimorbidity 82.35 12.23 27 34818 1493 110552961
Interstitial lung disease 71.10 12.23 144 34701 139190 110415264
Blood parathyroid hormone increased 67.77 12.23 31 34814 4217 110550237
Cerebral infarction 66.70 12.23 82 34763 51756 110502698
Product dose omission issue 59.78 12.23 14 34831 321768 110232686
Aplasia pure red cell 58.77 12.23 37 34808 9541 110544913
Transplant failure 56.60 12.23 30 34815 5605 110548849
Superinfection 53.18 12.23 29 34816 5734 110548720
Fatigue 50.39 12.23 205 34640 1215753 109338701
Peripheral arterial occlusive disease 47.51 12.23 32 34813 9248 110545206
Myocardial ischaemia 44.05 12.23 48 34797 26636 110527818
Oesophageal carcinoma 43.47 12.23 33 34812 11491 110542963
Disseminated intravascular coagulation 43.24 12.23 59 34786 41227 110513227
Inflammatory marker increased 42.96 12.23 36 34809 14433 110540021
Procalcitonin abnormal 42.54 12.23 12 34833 397 110554057
Platelet count decreased 40.73 12.23 162 34683 230281 110324173
Labelled drug-drug interaction medication error 40.38 12.23 48 34797 29254 110525200
Pneumonia aspiration 40.29 12.23 83 34762 81150 110473304
Nausea 40.26 12.23 227 34618 1235463 109318991
Hyperhidrosis 39.34 12.23 6 34839 187292 110367162
Calciphylaxis 38.44 12.23 21 34824 4166 110550288
Back pain 36.17 12.23 220 34625 370776 110183678
Anti-erythropoietin antibody negative 36.04 12.23 10 34835 311 110554143
Lung consolidation 35.17 12.23 28 34817 10448 110544006
Cardiac failure 34.85 12.23 134 34711 187492 110366962
Hyperuricaemia 34.81 12.23 32 34813 14499 110539955
Enteritis infectious 34.35 12.23 19 34826 3863 110550591
Nephrotic syndrome 34.19 12.23 31 34814 13800 110540654
Completed suicide 33.88 12.23 17 34828 242364 110312090
Milk-alkali syndrome 33.15 12.23 15 34830 1990 110552464
Pneumonia bacterial 32.91 12.23 41 34804 26220 110528234
Incorrect route of product administration 32.41 12.23 66 34779 63995 110490459
Large intestine polyp 31.84 12.23 31 34814 15086 110539368
Periodontitis 31.66 12.23 20 34825 5188 110549266
Gastroenteritis 31.27 12.23 49 34796 38751 110515703
Liver disorder 30.12 12.23 106 34739 142137 110412317
Muscle injury 29.88 12.23 105 34740 140702 110413752
Cardiomegaly 29.56 12.23 41 34804 29089 110525365
Enterocolitis 29.40 12.23 33 34812 18916 110535538
Injection site pain 28.85 12.23 10 34835 177912 110376542
Insomnia 28.55 12.23 203 34642 360387 110194067
Drug hypersensitivity 28.49 12.23 63 34782 454027 110100427
Atypical femur fracture 28.43 12.23 20 34825 6199 110548255
Decreased appetite 28.41 12.23 251 34594 475595 110078859
Prinzmetal angina 28.36 12.23 14 34831 2255 110552199
Tetany 27.47 12.23 16 34829 3588 110550866
Encephalomalacia 27.27 12.23 12 34833 1490 110552964
PCO2 decreased 26.68 12.23 15 34830 3146 110551308
Intentional overdose 26.16 12.23 5 34840 132496 110421958
Colon cancer 26.14 12.23 29 34816 16414 110538040
Lymph node palpable 26.07 12.23 7 34838 192 110554262
Urticaria 24.94 12.23 179 34666 318678 110235776
Peritonitis 24.66 12.23 40 34805 32567 110521887
Hyperkalaemia 24.41 12.23 96 34749 135700 110418754
Nephrogenic anaemia 23.95 12.23 16 34829 4561 110549893
Chronic gastritis 23.80 12.23 17 34828 5394 110549060
Hypocalcaemic seizure 23.56 12.23 6 34839 133 110554321
Maternal exposure during pregnancy 22.85 12.23 148 34697 254735 110299719
Marasmus 22.84 12.23 11 34834 1680 110552774
Folliculitis 22.83 12.23 109 34736 167544 110386910
Product use in unapproved indication 22.74 12.23 69 34776 447308 110107146
Beta 2 microglobulin urine increased 22.69 12.23 6 34839 155 110554299
Immobilisation syndrome 22.64 12.23 9 34836 867 110553587
Hypoglycaemia 22.44 12.23 84 34761 116020 110438434
Rales 22.42 12.23 33 34812 24706 110529748
Hungry bone syndrome 22.39 12.23 7 34838 332 110554122
Neuromyopathy 22.31 12.23 11 34834 1768 110552686
Drug ineffective for unapproved indication 22.28 12.23 3 34842 102835 110451619
Acute kidney injury 21.68 12.23 300 34545 635130 109919324
Pyrexia 21.59 12.23 400 34445 897865 109656589
Pneumocystis jirovecii pneumonia 21.58 12.23 44 34801 42691 110511763
Iron deficiency anaemia 21.57 12.23 37 34808 31522 110522932
Femoral neck fracture 21.43 12.23 23 34822 12544 110541910
Haemorrhage subcutaneous 21.20 12.23 16 34829 5523 110548931
Toxoplasmosis 21.10 12.23 13 34832 3226 110551228
Oncocytoma 20.93 12.23 4 34841 21 110554433
Depression 20.75 12.23 43 34802 317292 110237162
Sinusitis 20.62 12.23 162 34683 296526 110257928
Chronic obstructive pulmonary disease 19.76 12.23 5 34840 109153 110445301
Suicidal ideation 19.74 12.23 3 34842 93934 110460520
Plasmapheresis 19.68 12.23 8 34837 816 110553638
Ileus 19.67 12.23 35 34810 30694 110523760
Disease progression 19.65 12.23 29 34816 244005 110310449
Lower limb fracture 19.39 12.23 60 34785 75288 110479166
Drug level increased 19.38 12.23 45 34800 47674 110506780
Hypotension 19.36 12.23 92 34753 523757 110030697
Pharyngitis 19.27 12.23 31 34814 25067 110529387
Femur fracture 19.24 12.23 43 34802 44426 110510028
Diarrhoea 19.21 12.23 482 34363 1139023 109415431
Enterocolitis viral 19.17 12.23 8 34837 873 110553581
Premature rupture of membranes 19.10 12.23 14 34831 4623 110549831
Erythema multiforme 18.92 12.23 28 34817 21069 110533385
PO2 decreased 18.91 12.23 12 34833 3136 110551318
Osteomyelitis 18.86 12.23 38 34807 36562 110517892
Vanishing bile duct syndrome 18.84 12.23 12 34833 3156 110551298
Death 18.77 12.23 136 34709 698733 109855721
Torticollis 18.66 12.23 12 34833 3209 110551245
Retinopathy hypertensive 18.61 12.23 7 34838 581 110553873
Suicide attempt 18.22 12.23 5 34840 103389 110451065
Cholangitis 18.10 12.23 24 34821 16311 110538143
Grip strength 17.87 12.23 18 34827 9123 110545331
Haemodialysis complication 17.78 12.23 6 34839 363 110554091
Shunt malfunction 17.76 12.23 6 34839 364 110554090
Hypophosphataemia 17.75 12.23 35 34810 33147 110521307
Anaemia 17.72 12.23 256 34589 546830 110007624
Cardiac failure acute 17.48 12.23 29 34816 24049 110530405
Anti-saccharomyces cerevisiae antibody test positive 17.44 12.23 4 34841 56 110554398
Parathyroid hyperplasia 17.34 12.23 5 34840 179 110554275
Therapeutic drug monitoring analysis incorrectly performed 17.31 12.23 7 34838 705 110553749
Abdominal pain upper 17.26 12.23 177 34668 348934 110205520
Pruritus 17.23 12.23 268 34577 581292 109973162
Drug eruption 16.96 12.23 46 34799 53613 110500841
Deep vein thrombosis postoperative 16.94 12.23 49 34796 59242 110495212
Weight decreased 16.83 12.23 83 34762 467974 110086480
Flushing 16.78 12.23 6 34839 104730 110449724
Renal tubular acidosis 16.69 12.23 13 34832 4702 110549752
Vision blurred 16.64 12.23 10 34835 129012 110425442
Drug intolerance 16.45 12.23 69 34776 406443 110148011
Calculus urinary 16.45 12.23 11 34834 3141 110551313
Ascites 16.18 12.23 65 34780 92743 110461711
Shunt blood flow excessive 16.17 12.23 3 34842 13 110554441
Calcium metabolism disorder 16.15 12.23 4 34841 79 110554375
Treatment failure 16.14 12.23 40 34805 277194 110277260
Feeling abnormal 16.03 12.23 20 34825 180691 110373763
Hyperparathyroidism secondary 15.98 12.23 11 34834 3293 110551161
Neuropsychiatric lupus 15.91 12.23 5 34840 241 110554213
Pleural effusion 15.80 12.23 103 34742 177606 110376848
Underdose 15.79 12.23 50 34795 63504 110490950
Thalamus haemorrhage 15.71 12.23 9 34836 1955 110552499
Oesophageal mucosal tear 15.66 12.23 3 34842 16 110554438
C-reactive protein increased 15.14 12.23 119 34726 217800 110336654
Concomitant disease aggravated 15.08 12.23 22 34823 16342 110538112
Drug-induced liver injury 14.87 12.23 76 34769 119991 110434463
Device related sepsis 14.84 12.23 15 34830 7632 110546822
Premature delivery 14.83 12.23 31 34814 30601 110523853
Dermatophytosis of nail 14.76 12.23 5 34840 306 110554148
Thrombosis 14.62 12.23 8 34837 108654 110445800
Impaired healing 14.54 12.23 109 34736 196608 110357846
Protein urine present 14.50 12.23 18 34827 11466 110542988
Pain in extremity 14.45 12.23 92 34753 487026 110067428
Injection site reaction 14.45 12.23 5 34840 89065 110465389
Organising pneumonia 14.38 12.23 20 34825 14223 110540231
Contusion 14.37 12.23 124 34721 233237 110321217
Anxiety 14.32 12.23 58 34787 345020 110209434
Community acquired infection 14.29 12.23 3 34842 27 110554427
Skin erosion 14.23 12.23 13 34832 5841 110548613
Cholecystitis acute 14.23 12.23 21 34824 15761 110538693
Encephalopathy 14.13 12.23 4 34841 81051 110473403
Haemoptysis 14.10 12.23 52 34793 71302 110483152
Aortic dissection 14.08 12.23 12 34833 4921 110549533
Peritoneal cloudy effluent 14.04 12.23 6 34839 694 110553760
Oxalosis 13.96 12.23 4 34841 140 110554314
Febrile neutropenia 13.94 12.23 52 34793 316715 110237739
Diabetes mellitus 13.80 12.23 65 34780 99316 110455138
Myeloperoxidase deficiency 13.75 12.23 3 34842 33 110554421
Palpitations 13.73 12.23 18 34827 159194 110395260
Balance disorder 13.73 12.23 10 34835 116550 110437904
Hyperphosphataemia 13.64 12.23 21 34824 16360 110538094
Osteoporosis 13.60 12.23 59 34786 87093 110467361
Puncture site erythema 13.58 12.23 3 34842 35 110554419
Precocious puberty 13.52 12.23 5 34840 396 110554058
Drug interaction 13.50 12.23 227 34618 499956 110054498
Gastric cancer 13.49 12.23 17 34828 10991 110543463
Idiopathic interstitial pneumonia 13.38 12.23 6 34839 779 110553675
Pemphigoid 13.33 12.23 23 34822 19684 110534770
Heat illness 13.33 12.23 6 34839 786 110553668
Shunt aneurysm 13.21 12.23 3 34842 40 110554414
Stag horn calculus 13.10 12.23 4 34841 175 110554279
Pain 13.07 12.23 217 34628 954738 109599716
Abdominal discomfort 12.94 12.23 72 34773 393786 110160668
Hypokalaemia 12.87 12.23 100 34745 182348 110372106
Thoracic vertebral fracture 12.82 12.23 13 34832 6642 110547812
Coma 12.76 12.23 11 34834 117858 110436596
Influenza like illness 12.65 12.23 6 34839 88406 110466048
Haemoglobin increased 12.63 12.23 15 34830 9132 110545322
Therapeutic product effect incomplete 12.48 12.23 33 34812 223772 110330682
Vomiting 12.42 12.23 375 34470 910300 109644154
Immune thrombocytopenia 12.37 12.23 24 34821 22470 110531984
Hepatic cyst infection 12.33 12.23 4 34841 214 110554240
Autoimmune pancytopenia 12.29 12.23 4 34841 216 110554238
Blood albumin decreased 12.26 12.23 27 34818 27625 110526829
Altered state of consciousness 12.24 12.23 43 34802 57583 110496871

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CC03 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC M05BB06 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
MeSH PA D050071 Bone Density Conservation Agents
CHEBI has role CHEBI:50646 bone density conservation agent

Related Drugs by ATC class:

A11CC Vitamin D and analogues 5 drugs
calcifediolcalcitriolcolecalciferoldihydrotachysterolergocalciferol
M05BB Bisphosphonates, combinations 6 drugs
alendronic acidcolecalciferoletidronic acidibandronic acidrisedronic acidzoledronic acid

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Renal osteodystrophy indication 16726004 DOID:13068
Hypoparathyroidism indication 36976004 DOID:11199
Hyperparathyroidism indication 66999008 DOID:13543
Neonatal hypocalcemia indication 268846006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.7 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST WOMBAT-PK KEGG DRUG
Sodium-dependent noradrenaline transporter Transporter Ki 6 DRUG MATRIX

External reference:

IDSource
D01518 KEGG_DRUG
12062 RXNORM
C0044410 UMLSCUI
CHEBI:31186 CHEBI
CHEMBL1601669 ChEMBL_ID
DB01436 DRUGBANK_ID
C008088 MESH_SUPPLEMENTAL_RECORD_UI
5282181 PUBCHEM_CID
4489 INN_ID
URQ2517572 UNII
M9B PDB_CHEM_ID
003501 NDDF
11984007 SNOMEDCT_US
329325000 SNOMEDCT_US
URQ2517572 INXIGHT DRUGS

Pharmaceutical products:

None