strontium ranelate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4714	135459-87-9

Description:

Molecule	Description
Synonyms: strontium ranelate osseor bivalos distrontium renelate protelos	an uncoupling agent containing strontium prevents bone loss by depressing bone resorption & maintaining bone formation in estrogen-deficient rats Molecular weight: 513.49 Formula: C12H6N2O8SSr2 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 187.55 ALOGS: ROTB: None

Molecule

Description

Synonyms:

strontium ranelate
osseor
bivalos
distrontium renelate
protelos

an uncoupling agent containing strontium prevents bone loss by depressing bone resorption & maintaining bone formation in estrogen-deficient rats

Molecular weight: 513.49
Formula: C12H6N2O8SSr2
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 187.55
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
2	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Sept. 21, 2004	EMA	Les Laboratoires Servier

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Metaphyseal corner fracture	80.76	52.97	8	189	32	63488793

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FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Metaphyseal corner fracture	83.18	50.61	8	175	32	79744173
Atypical fracture	51.74	50.61	7	176	699	79743506

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	M05BX03	MUSCULO-SKELETAL SYSTEM DRUGS FOR TREATMENT OF BONE DISEASES DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION Other drugs affecting bone structure and mineralization
ATC	M05BX53	MUSCULO-SKELETAL SYSTEM DRUGS FOR TREATMENT OF BONE DISEASES DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION Other drugs affecting bone structure and mineralization
MeSH PA	D050071	Bone Density Conservation Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Postmenopausal osteoporosis	indication	102447009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
010550	NDDF
04NQ160FRU	UNII
432727001	SNOMEDCT_US
441487000	SNOMEDCT_US
6918182	PUBCHEM_CID
C081587	MESH_SUPPLEMENTAL_RECORD_UI
C0936139	UMLSCUI
CHEMBL3707306	ChEMBL_ID
DB09267	DRUGBANK_ID

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Pharmaceutical products:

None