ibandronic acid ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium metabolism regulator, pharmaceutical aid 1404 114084-78-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bonviva
  • ibandronic acid
  • ibandronate
  • boniva
  • ibandronate sodium
Aminobisphosphonate that is a potent inhibitor of BONE RESORPTION. It is used in the treatment of HYPERCALCEMIA associated with malignancy, for the prevention of fracture and bone complications in patients with breast cancer and bone metastases, and for the treatment and prevention of POSTMENOPAUSAL OSTEOPOROSIS.
  • Molecular weight: 319.23
  • Formula: C9H23NO7P2
  • CLOGP: -1.52
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 5
  • TPSA: 138.53
  • ALOGS: -1.38
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O
6 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 55 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.13 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.55 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.15 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 14 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 25, 1996 EMA Atnahs Pharma Netherlands B.V.
May 16, 2003 FDA HOFFMANN LA ROCHE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis of jaw 1514.99 12.09 647 42592 34476 63411307
Femur fracture 1348.16 12.09 628 42611 41128 63404655
Low turnover osteopathy 623.82 12.09 193 43046 3992 63441791
Osteonecrosis 621.95 12.09 313 42926 24217 63421566
Bone pain 600.61 12.09 405 42834 54236 63391547
Atypical femur fracture 448.44 12.09 160 43079 5212 63440571
Stress fracture 397.41 12.09 163 43076 7800 63437983
Myalgia 273.11 12.09 412 42827 146117 63299666
Intramedullary rod insertion 266.89 12.09 86 43153 2037 63443746
Drug ineffective 248.21 12.09 210 43029 1044555 62401228
Fracture nonunion 224.71 12.09 77 43162 2218 63443565
Exposed bone in jaw 217.49 12.09 80 43159 2845 63442938
Osteomyelitis 190.45 12.09 151 43088 25869 63419914
Influenza like illness 182.08 12.09 226 43013 66598 63379185
Dental caries 181.80 12.09 105 43134 10674 63435109
Tooth extraction 178.50 12.09 102 43137 10162 63435621
Pain in jaw 178.31 12.09 182 43057 43314 63402469
Bone disorder 165.23 12.09 128 43111 21198 63424585
Jaw disorder 164.69 12.09 78 43161 5271 63440512
Tooth disorder 159.66 12.09 141 43098 28016 63417767
Injection site extravasation 154.12 12.09 88 43151 8753 63437030
Off label use 151.81 12.09 142 43097 674320 62771463
Anaemia postoperative 150.89 12.09 57 43182 2185 63443598
Fall 145.77 12.09 590 42649 391744 63054039
Foot fracture 144.13 12.09 124 43115 23790 63421993
Vitamin D deficiency 143.00 12.09 99 43140 13793 63431990
Pain in extremity 139.80 12.09 519 42720 330967 63114816
Gastrooesophageal reflux disease 135.89 12.09 238 43001 95401 63350382
Maternal exposure during pregnancy 135.39 12.09 3 43236 220059 63225724
Metastases to bone 128.73 12.09 110 43129 20909 63424874
Back pain 127.97 12.09 433 42806 263712 63182071
Acute phase reaction 126.70 12.09 31 43208 252 63445531
Tooth fracture 125.83 12.09 84 43155 11026 63434757
Fracture delayed union 122.25 12.09 50 43189 2372 63443411
Spinal osteoarthritis 120.72 12.09 95 43144 16091 63429692
Pathological fracture 120.30 12.09 75 43164 8759 63437024
Osteoarthritis 118.60 12.09 224 43015 95119 63350664
Open reduction of fracture 117.72 12.09 40 43199 1122 63444661
Exostosis of jaw 117.49 12.09 41 43198 1248 63444535
Arthralgia 116.31 12.09 723 42516 568987 62876796
Infusion related reaction 111.61 12.09 17 43222 245504 63200279
Product use issue 108.08 12.09 12 43227 220508 63225275
Periodontal disease 104.08 12.09 40 43199 1608 63444175
Condition aggravated 103.54 12.09 74 43165 402143 63043640
Hyperlipidaemia 101.07 12.09 93 43146 19478 63426305
Fracture displacement 95.64 12.09 35 43204 1226 63444557
Hand deformity 94.96 12.09 3 43236 159454 63286329
Extravasation 93.23 12.09 41 43198 2331 63443452
Sequestrectomy 89.87 12.09 30 43209 796 63444987
Osteitis 89.47 12.09 44 43195 3230 63442553
Spinal compression fracture 87.97 12.09 75 43164 14208 63431575
Treatment failure 87.71 12.09 15 43224 199028 63246755
Drug intolerance 87.28 12.09 51 43188 308610 63137173
Ulna fracture 83.10 12.09 31 43208 1147 63444636
Fracture 82.14 12.09 83 43156 19501 63426282
Device failure 81.76 12.09 51 43188 5960 63439823
Systemic lupus erythematosus 81.27 12.09 21 43218 208897 63236886
Rib fracture 79.15 12.09 87 43152 22510 63423273
Osteopenia 76.02 12.09 80 43159 19705 63426078
Glossodynia 75.54 12.09 15 43224 178861 63266922
Atypical fracture 72.79 12.09 24 43215 612 63445171
Periprosthetic fracture 71.67 12.09 22 43217 442 63445341
Lower respiratory tract infection 70.73 12.09 5 43234 132302 63313481
Synovitis 70.42 12.09 20 43219 186898 63258885
Femoral neck fracture 70.05 12.09 53 43186 8470 63437313
Gingivitis 68.36 12.09 52 43187 8377 63437406
Pelvic fracture 68.09 12.09 63 43176 13285 63432498
Metastases to liver 67.64 12.09 82 43157 23557 63422226
Hepatic enzyme increased 66.93 12.09 27 43212 202301 63243482
Temporomandibular joint syndrome 66.74 12.09 39 43200 4050 63441733
Carbohydrate antigen 15-3 increased 66.69 12.09 28 43211 1420 63444363
Abscess jaw 64.20 12.09 27 43212 1375 63444408
Product use in unapproved indication 64.14 12.09 21 43218 179059 63266724
Therapeutic product effect decreased 63.54 12.09 26 43213 193161 63252622
Resorption bone increased 63.28 12.09 26 43213 1248 63444535
Joint swelling 62.36 12.09 79 43160 327587 63118196
Toxicity to various agents 61.58 12.09 47 43192 247203 63198580
Fibrocystic breast disease 61.50 12.09 25 43214 1167 63444616
Actinomycosis 61.04 12.09 24 43215 1026 63444757
Bone density decreased 59.58 12.09 61 43178 14551 63431232
Gingival disorder 58.38 12.09 34 43205 3508 63442275
Periodontitis 57.89 12.09 33 43206 3270 63442513
Intervertebral disc degeneration 57.59 12.09 62 43177 15670 63430113
Osteoporosis 57.26 12.09 123 43116 57215 63388568
Toothache 57.23 12.09 68 43171 19131 63426652
Impaired healing 56.65 12.09 176 43063 102366 63343417
Therapeutic product effect incomplete 56.01 12.09 9 43230 125047 63320736
Injection site inflammation 55.81 12.09 34 43205 3809 63441974
Tooth loss 54.95 12.09 42 43197 6814 63438969
Bone loss 54.42 12.09 31 43208 3068 63442715
Diverticulum 54.31 12.09 53 43186 11938 63433845
Spondylolisthesis 53.20 12.09 32 43207 3504 63442279
Oral cavity fistula 52.31 12.09 19 43220 651 63445132
Musculoskeletal pain 51.54 12.09 159 43080 92118 63353665
Jaw operation 51.39 12.09 20 43219 832 63444951
Jaw fracture 50.74 12.09 28 43211 2606 63443177
Wound 50.48 12.09 24 43215 163239 63282544
Spinal fracture 50.04 12.09 62 43177 18209 63427574
Dyspepsia 49.75 12.09 168 43071 102028 63343755
Loose tooth 49.22 12.09 30 43209 3364 63442419
Chest pain 48.20 12.09 281 42958 215678 63230105
Discomfort 48.19 12.09 27 43212 167347 63278436
Isosthenuria 47.96 12.09 12 43227 108 63445675
Tooth abscess 47.92 12.09 55 43184 14914 63430869
Fatigue 47.86 12.09 382 42857 887646 62558137
Nasopharyngitis 47.63 12.09 62 43177 254195 63191588
Hypothyroidism 46.70 12.09 95 43144 42537 63403246
Scoliosis 45.69 12.09 40 43199 7848 63437935
Oesophagitis 44.47 12.09 53 43186 14955 63430828
Hypersensitivity 43.77 12.09 83 43156 292602 63153181
Medical device removal 43.58 12.09 20 43219 1257 63444526
Fistula 43.49 12.09 44 43195 10349 63435434
Calcium deficiency 42.95 12.09 19 43220 1095 63444688
Hip fracture 42.65 12.09 74 43165 29400 63416383
Metastases to pleura 42.41 12.09 21 43218 1564 63444219
Radius fracture 42.40 12.09 28 43211 3607 63442176
Bursitis 42.31 12.09 84 43155 36957 63408826
Renal cyst 41.99 12.09 43 43196 10259 63435524
Blister 41.82 12.09 18 43221 129796 63315987
Vertebral foraminal stenosis 41.80 12.09 18 43221 972 63444811
Oral infection 41.06 12.09 31 43208 4937 63440846
Pyelitis 40.64 12.09 12 43227 210 63445573
Groin pain 40.53 12.09 42 43197 10161 63435622
Breast cancer recurrent 40.18 12.09 29 43210 4312 63441471
Gingival swelling 39.72 12.09 29 43210 4389 63441394
Bladder hypertrophy 39.72 12.09 12 43227 228 63445555
Rheumatoid arthritis 39.71 12.09 70 43169 253749 63192034
Hyperaesthesia teeth 39.69 12.09 21 43218 1797 63443986
Lumbar spinal stenosis 39.66 12.09 30 43209 4792 63440991
Meniscus injury 39.07 12.09 35 43204 7079 63438704
Rotator cuff syndrome 38.89 12.09 47 43192 13455 63432328
Drug abuse 38.01 12.09 3 43236 72515 63373268
Electrocardiogram PR shortened 37.77 12.09 12 43227 271 63445512
Product dose omission issue 37.21 12.09 64 43175 234249 63211534
Gastritis 37.21 12.09 80 43159 37223 63408560
Folliculitis 36.60 12.09 3 43236 70314 63375469
Pulpitis dental 36.34 12.09 16 43223 912 63444871
Osteomalacia 36.31 12.09 15 43224 730 63445053
Hydrothorax 36.29 12.09 16 43223 915 63444868
Pneumonia 36.21 12.09 174 43065 456593 62989190
Congenital coronary artery malformation 36.07 12.09 10 43229 138 63445645
Compression fracture 35.96 12.09 32 43207 6416 63439367
Dental necrosis 35.81 12.09 10 43229 142 63445641
Exostosis 35.72 12.09 52 43187 17810 63427973
Endodontic procedure 35.71 12.09 24 43215 3183 63442600
Intentional product use issue 34.88 12.09 22 43217 127870 63317913
Rash 34.56 12.09 232 43007 560639 62885144
COVID-19 34.38 12.09 17 43222 113086 63332697
Oxygen saturation decreased 34.24 12.09 9 43230 88576 63357207
Hypercholesterolaemia 34.10 12.09 56 43183 21278 63424505
Tonsillectomy 33.98 12.09 15 43224 860 63444923
Intentional overdose 33.96 12.09 5 43234 74147 63371636
Hiatus hernia 33.60 12.09 56 43183 21538 63424245
Peripheral swelling 33.47 12.09 83 43156 265859 63179924
Oesophageal stenosis 32.96 12.09 23 43216 3243 63442540
Phlebitis 32.87 12.09 31 43208 6693 63439090
Wrist fracture 32.32 12.09 43 43196 13544 63432239
Blood loss anaemia 32.12 12.09 35 43204 8966 63436817
Bone sequestrum 32.11 12.09 17 43222 1457 63444326
Haemorrhoids 31.25 12.09 55 43184 22095 63423688
Dysphagia 30.96 12.09 131 43108 88454 63357329
Product administration error 30.81 12.09 55 43184 22342 63423441
Hysterectomy 30.57 12.09 35 43204 9464 63436319
Liver injury 30.37 12.09 3 43236 60517 63385266
Weight increased 30.07 12.09 85 43154 260707 63185076
Intervertebral disc protrusion 29.81 12.09 56 43183 23653 63422130
Oesophageal disorder 29.44 12.09 19 43220 2354 63443429
Metastases to adrenals 29.34 12.09 13 43226 752 63445031
Mitral valve prolapse 29.30 12.09 19 43220 2374 63443409
Internal fixation of fracture 29.21 12.09 13 43226 760 63445023
Drug hypersensitivity 29.10 12.09 111 43128 310576 63135207
Osteocalcin decreased 29.05 12.09 7 43232 53 63445730
Psoriatic arthropathy 28.98 12.09 13 43226 91507 63354276
Arteriosclerosis 28.93 12.09 35 43204 10031 63435752
Alopecia 28.85 12.09 125 43114 337411 63108372
Jaw fistula 28.82 12.09 7 43232 55 63445728
Muscle injury 28.59 12.09 5 43234 65340 63380443
Pruritus 28.43 12.09 138 43101 361315 63084468
Kyphosis 28.27 12.09 19 43220 2521 63443262
Rectocele 28.22 12.09 14 43225 1047 63444736
Musculoskeletal chest pain 28.02 12.09 51 43188 21032 63424751
Limb asymmetry 27.89 12.09 13 43226 847 63444936
Muscle spasms 27.87 12.09 192 43047 155958 63289825
Metastases to lymph nodes 27.86 12.09 31 43208 8127 63437656
Cough 27.80 12.09 104 43135 292639 63153144
Hypotension 27.78 12.09 94 43145 272510 63173273
Osteochondrosis 27.52 12.09 15 43224 1362 63444421
Lumbar radiculopathy 27.52 12.09 17 43222 1952 63443831
Humerus fracture 27.26 12.09 32 43207 8884 63436899
Cellulitis 26.95 12.09 119 43120 81839 63363944
Carcinoembryonic antigen increased 26.62 12.09 16 43223 1749 63444034
Confusional state 26.55 12.09 78 43161 236302 63209481
Dental implantation 26.52 12.09 12 43227 730 63445053
Febrile neutropenia 26.42 12.09 25 43214 118424 63327359
Comminuted fracture 26.40 12.09 11 43228 547 63445236
Bone graft 26.38 12.09 13 43226 958 63444825
Hormone receptor positive HER2 negative breast cancer 26.38 12.09 8 43231 154 63445629
Depression 26.35 12.09 226 43013 196266 63249517
Tibia fracture 25.79 12.09 24 43215 5096 63440687
Multiple organ dysfunction syndrome 25.59 12.09 4 43235 56748 63389035
Calcification metastatic 25.25 12.09 8 43231 179 63445604
Creatinine renal clearance increased 24.97 12.09 11 43228 628 63445155
Dental fistula 24.95 12.09 11 43228 629 63445154
Hypertension 24.79 12.09 295 42944 279008 63166775
Lymphoedema 24.79 12.09 35 43204 11657 63434126
Invasive ductal breast carcinoma 24.73 12.09 27 43212 6931 63438852
Depressed level of consciousness 24.58 12.09 6 43233 62072 63383711
Goitre 24.51 12.09 25 43214 5936 63439847
Dental plaque 24.18 12.09 7 43232 114 63445669
Muscle strain 24.15 12.09 29 43210 8245 63437538
Hospitalisation 24.08 12.09 14 43225 85067 63360716
Thoracic vertebral fracture 24.05 12.09 22 43217 4570 63441213
Injection site swelling 23.84 12.09 79 43160 47493 63398290
Patella fracture 23.62 12.09 16 43223 2150 63443633
Arthropathy 23.21 12.09 82 43157 234710 63211073
Breast calcifications 23.02 12.09 13 43226 1265 63444518
Upper limb fracture 22.85 12.09 44 43195 18924 63426859
Large intestine polyp 22.85 12.09 28 43211 8129 63437654
Wheezing 22.73 12.09 19 43220 95576 63350207
Seborrhoeic keratosis 22.49 12.09 16 43223 2326 63443457
PIK3CA-activated mutation 22.46 12.09 12 43227 1047 63444736
Cataract operation 22.42 12.09 23 43216 5499 63440284
Stress urinary incontinence 22.41 12.09 16 43223 2339 63443444
Oestrogen deficiency 22.08 12.09 7 43232 157 63445626
Suicide attempt 22.05 12.09 7 43232 60911 63384872
Sinusitis 21.84 12.09 80 43159 226573 63219210
Spondylolysis 21.77 12.09 6 43233 81 63445702
Tonsillar disorder 21.51 12.09 12 43227 1141 63444642
Lumbar vertebral fracture 21.44 12.09 23 43216 5787 63439996
Appendicectomy 21.37 12.09 17 43222 2922 63442861
Poor dental condition 21.35 12.09 9 43230 461 63445322
Spinal stenosis 20.98 12.09 37 43202 14888 63430895
Gastrointestinal tract irritation 20.80 12.09 9 43230 492 63445291
Oral surgery 20.75 12.09 12 43227 1222 63444561
Varicose vein 20.63 12.09 21 43218 4974 63440809
Skeletal injury 20.60 12.09 12 43227 1238 63444545
Hand fracture 20.33 12.09 22 43217 5591 63440192
Tooth avulsion 20.29 12.09 5 43234 42 63445741
Bone fragmentation 20.04 12.09 10 43229 757 63445026
Breath odour 20.00 12.09 12 43227 1308 63444475
Metastases to spine 19.88 12.09 17 43222 3232 63442551
Metastases to skin 19.86 12.09 13 43226 1650 63444133
Osteoporotic fracture 19.72 12.09 18 43221 3728 63442055
Injection site phlebitis 19.52 12.09 6 43233 121 63445662
Bone lesion 19.49 12.09 22 43217 5859 63439924
Oral pustule 19.42 12.09 5 43234 51 63445732
Spinal meningeal cyst 19.33 12.09 5 43234 52 63445731
Somnolence 19.31 12.09 60 43179 178625 63267158
Blood pressure fluctuation 19.29 12.09 4 43235 46313 63399470
Eructation 19.25 12.09 26 43213 8307 63437476
Platelet count decreased 19.08 12.09 31 43208 116091 63329692
Polyneuropathy 19.02 12.09 35 43204 14554 63431229
Arterial thrombosis 19.01 12.09 12 43227 1431 63444352
Postmenopause 18.99 12.09 5 43234 56 63445727
Heart rate decreased 18.84 12.09 4 43235 45556 63400227
Gingival recession 18.83 12.09 12 43227 1455 63444328
Osteogenesis imperfecta 18.78 12.09 9 43230 624 63445159
Barrett's oesophagus 18.75 12.09 9 43230 626 63445157
Breast mass 18.73 12.09 25 43214 7897 63437886
Tooth infection 18.52 12.09 39 43200 17881 63427902
Breast cancer metastatic 18.47 12.09 31 43208 11987 63433796
Cystocele 18.47 12.09 11 43228 1183 63444600
Hypertonic bladder 18.42 12.09 17 43222 3571 63442212
Cholecystectomy 18.39 12.09 29 43210 10648 63435135
Oral disorder 18.03 12.09 26 43213 8828 63436955
White blood cell count decreased 17.80 12.09 43 43196 139061 63306722
Drug-induced liver injury 17.77 12.09 3 43236 40219 63405564
Fractured sacrum 17.60 12.09 13 43226 2003 63443780
Malaise 17.49 12.09 190 43049 415764 63030019
Blood bilirubin abnormal 17.48 12.09 10 43229 997 63444786
Bone formation increased 17.40 12.09 6 43233 176 63445607
Pancreatic steatosis 17.40 12.09 10 43229 1006 63444777
Spinal disorder 17.20 12.09 27 43212 9875 63435908
Abdominal discomfort 17.17 12.09 138 43101 320747 63125036
Wound haemorrhage 17.12 12.09 14 43225 2502 63443281
Dyslipidaemia 16.98 12.09 23 43216 7370 63438413
Arthritis 16.95 12.09 136 43103 115785 63329998
Erosive oesophagitis 16.91 12.09 12 43227 1738 63444045
Rhinorrhoea 16.90 12.09 12 43227 65565 63380218
Atrophic vulvovaginitis 16.80 12.09 12 43227 1756 63444027
Cerumen impaction 16.72 12.09 10 43229 1084 63444699
Anxiety disorder 16.68 12.09 17 43222 4033 63441750
Gingival pain 16.67 12.09 24 43215 8138 63437645
Neck pain 16.62 12.09 92 43147 69226 63376557
Mediastinal disorder 16.50 12.09 7 43232 364 63445419
Injection site thrombosis 16.40 12.09 5 43234 98 63445685
Chronic hepatic failure 16.32 12.09 8 43231 583 63445200
Hypophosphataemic osteomalacia 16.29 12.09 6 43233 214 63445569
Oesophageal pain 16.09 12.09 16 43223 3685 63442098
Hyperparathyroidism 16.04 12.09 14 43225 2735 63443048
Bone metabolism disorder 16.03 12.09 7 43232 391 63445392
Loss of personal independence in daily activities 15.96 12.09 26 43213 97264 63348519
Bone lesion excision 15.89 12.09 4 43235 37 63445746
Mobility decreased 15.86 12.09 37 43202 121122 63324661
No adverse event 15.86 12.09 63 43176 41342 63404441
Death 15.74 12.09 171 43068 374210 63071573
Purulence 15.69 12.09 11 43228 1563 63444220
Oesophageal rupture 15.60 12.09 8 43231 642 63445141
Pulmonary oedema 15.57 12.09 9 43230 54864 63390919
Tooth deposit 15.54 12.09 6 43233 244 63445539
Cardio-respiratory arrest 15.42 12.09 11 43228 59948 63385835
Vascular procedure complication 15.27 12.09 3 43236 7 63445776
Ankle fracture 15.24 12.09 36 43203 17819 63427964
Tendonitis 15.09 12.09 38 43201 19577 63426206
Chest wall tumour 15.02 12.09 4 43235 47 63445736
Jaw cyst 15 12.09 5 43234 132 63445651
Drug interaction 14.96 12.09 93 43146 229038 63216745
Synovial cyst 14.84 12.09 26 43213 10407 63435376
Fibula fracture 14.83 12.09 15 43224 3527 63442256
Induration 14.79 12.09 10 43229 1340 63444443
Therapy non-responder 14.72 12.09 18 43221 75883 63369900
Cognitive disorder 14.67 12.09 10 43229 55805 63389978
Metastases to the mediastinum 14.67 12.09 7 43232 481 63445302
Metastases to lung 14.66 12.09 29 43210 12721 63433062
Ligament sprain 14.58 12.09 29 43210 12771 63433012
Peritoneal disorder 14.48 12.09 7 43232 495 63445288
Oral fibroma 14.44 12.09 4 43235 55 63445728
Ovarian cancer stage III 14.43 12.09 6 43233 297 63445486
Tendon calcification 14.31 12.09 4 43235 57 63445726
Dental care 14.21 12.09 9 43230 1080 63444703
Disease progression 14.14 12.09 40 43199 122718 63323065
Suicidal ideation 14.12 12.09 13 43226 62408 63383375
Agitation 14.05 12.09 12 43227 59745 63386038
Biopsy bone 14.00 12.09 4 43235 62 63445721
Sinus arrhythmia 14.00 12.09 10 43229 1463 63444320
Type V hyperlipidaemia 13.99 12.09 7 43232 533 63445250
Septic shock 13.78 12.09 15 43224 66614 63379169
Acute kidney injury 13.76 12.09 114 43125 263301 63182482
Appendix disorder 13.72 12.09 10 43229 1509 63444274
Macular hole 13.71 12.09 8 43231 828 63444955
Dental prosthesis user 13.66 12.09 4 43235 68 63445715
Rhinoplasty 13.51 12.09 3 43236 15 63445768
Malignant neoplasm progression 13.48 12.09 99 43140 82022 63363761
Intentional product misuse 13.41 12.09 13 43226 60904 63384879
Blood alkaline phosphatase decreased 13.38 12.09 9 43230 1196 63444587
Metabolic acidosis 13.35 12.09 7 43232 45062 63400721
Parkinson's disease 13.28 12.09 9 43230 1210 63444573
Peri-implantitis 13.19 12.09 4 43235 77 63445706
Cardiac arrest 13.15 12.09 27 43212 92518 63353265
Swelling 13.14 12.09 122 43117 275256 63170527
Oesophageal discomfort 13.08 12.09 5 43234 198 63445585
Bone marrow oedema 13.06 12.09 9 43230 1243 63444540
Injection site cellulitis 13.05 12.09 9 43230 1245 63444538
Blood parathyroid hormone increased 12.96 12.09 13 43226 3025 63442758
Radiotherapy 12.84 12.09 6 43233 393 63445390
Tongue geographic 12.78 12.09 4 43235 86 63445697
Oral neoplasm 12.73 12.09 4 43235 87 63445696
Oral dysaesthesia 12.73 12.09 4 43235 87 63445696
Respiratory failure 12.63 12.09 32 43207 101826 63343957
Illness 12.61 12.09 9 43230 49050 63396733
Serratia infection 12.59 12.09 8 43231 965 63444818
Cataract 12.54 12.09 74 43165 56979 63388804
Malocclusion 12.52 12.09 4 43235 92 63445691
General physical health deterioration 12.50 12.09 83 43156 201319 63244464
Eustachian tube dysfunction 12.49 12.09 6 43233 418 63445365
Post procedural constipation 12.48 12.09 4 43235 93 63445690
Neutrophil count decreased 12.46 12.09 12 43227 56394 63389389
X-ray of pelvis and hip abnormal 12.42 12.09 3 43236 23 63445760
Arthroscopy 12.28 12.09 7 43232 693 63445090
Eustachian tube disorder 12.21 12.09 4 43235 100 63445683
Oedema peripheral 12.20 12.09 189 43050 189322 63256461
Drug ineffective for unapproved indication 12.17 12.09 4 43235 34059 63411724
Chromatopsia 12.14 12.09 6 43233 445 63445338

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis of jaw 151.50 21.96 53 2206 17836 34936836
Osteonecrosis 99.28 21.96 37 2222 14853 34939819
Appetite disorder 40.03 21.96 12 2247 2459 34952213
Femur fracture 39.25 21.96 16 2243 8108 34946564
Rectal polyp 38.46 21.96 9 2250 710 34953962
Jaw fracture 30.18 21.96 8 2251 1050 34953622
Fall 25.09 21.96 46 2213 202839 34751833

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis of jaw 1517.85 12.81 575 28322 42651 79672840
Femur fracture 828.12 12.81 361 28536 38291 79677200
Osteonecrosis 521.65 12.81 245 28652 30850 79684641
Atypical femur fracture 465.64 12.81 140 28757 5049 79710442
Bone pain 402.60 12.81 251 28646 55491 79660000
Low turnover osteopathy 297.71 12.81 80 28817 1906 79713585
Stress fracture 251.63 12.81 93 28804 6387 79709104
Exposed bone in jaw 215.85 12.81 72 28825 3648 79711843
Osteomyelitis 183.36 12.81 126 28771 32739 79682752
Dental caries 155.65 12.81 79 28818 11741 79703750
Pain in jaw 153.54 12.81 130 28767 46021 79669470
Myalgia 150.01 12.81 253 28644 185388 79530103
Fracture nonunion 144.90 12.81 43 28854 1479 79714012
Jaw disorder 144.83 12.81 58 28839 4948 79710543
Bone disorder 135.16 12.81 85 28812 19028 79696463
Tooth disorder 133.32 12.81 95 28802 26138 79689353
Influenza like illness 130.52 12.81 145 28752 71562 79643929
Arthralgia 127.52 12.81 475 28422 571328 79144163
Pain in extremity 122.00 12.81 348 28549 364190 79351301
Acute phase reaction 121.26 12.81 28 28869 348 79715143
Tooth fracture 117.64 12.81 65 28832 11465 79704026
Injection site extravasation 116.84 12.81 61 28836 9608 79705883
Exostosis of jaw 113.19 12.81 34 28863 1220 79714271
Drug ineffective 111.91 12.81 137 28760 1080776 78634715
Tooth extraction 109.48 12.81 61 28836 10934 79704557
Fall 108.53 12.81 405 28492 487224 79228267
Pathological fracture 100.95 12.81 57 28840 10480 79705011
Sequestrectomy 98.21 12.81 28 28869 834 79714657
Fracture displacement 94.48 12.81 30 28867 1298 79714193
Osteitis 91.42 12.81 39 28858 3904 79711587
Foot fracture 90.17 12.81 70 28827 21911 79693580
Fracture delayed union 88.27 12.81 32 28865 2078 79713413
Back pain 87.11 12.81 275 28622 303905 79411586
Metastases to bone 83.67 12.81 70 28827 24357 79691134
Actinomycosis 82.60 12.81 26 28871 1093 79714398
Off label use 80.71 12.81 128 28769 907087 78808404
Ulna fracture 77.89 12.81 25 28872 1120 79714371
Atypical fracture 76.26 12.81 22 28875 684 79714807
Impaired healing 75.43 12.81 123 28774 87532 79627959
Gastrooesophageal reflux disease 68.59 12.81 130 28767 104116 79611375
Spinal compression fracture 67.38 12.81 53 28844 16905 79698586
Jaw fracture 67.17 12.81 29 28868 2988 79712503
Femoral neck fracture 67.08 12.81 43 28854 9941 79705550
Gingivitis 65.99 12.81 41 28856 8980 79706511
Oral cavity fistula 63.08 12.81 19 28878 688 79714803
Periodontal disease 62.30 12.81 24 28873 1846 79713645
Carbohydrate antigen 15-3 increased 61.23 12.81 21 28876 1158 79714333
Jaw operation 60.10 12.81 19 28878 810 79714681
Toxicity to various agents 59.38 12.81 40 28857 421500 79293991
Fracture 55.82 12.81 53 28844 21748 79693743
Isosthenuria 55.19 12.81 12 28885 111 79715380
Breast cancer recurrent 54.67 12.81 25 28872 2952 79712539
Temporomandibular joint syndrome 54.04 12.81 27 28870 3878 79711613
Anaemia postoperative 51.75 12.81 21 28876 1853 79713638
Fistula 50.46 12.81 40 28857 12900 79702591
Abscess jaw 49.70 12.81 20 28877 1727 79713764
Oral infection 49.66 12.81 29 28868 5678 79709813
Extravasation 49.17 12.81 25 28872 3725 79711766
Vitamin D deficiency 49.06 12.81 41 28856 14238 79701253
Gingival disorder 46.89 12.81 24 28873 3627 79711864
Tooth abscess 46.52 12.81 42 28855 16168 79699323
Infusion related reaction 46.35 12.81 13 28884 230224 79485267
Hydrothorax 45.93 12.81 18 28879 1450 79714041
Condition aggravated 45.08 12.81 70 28827 501054 79214437
Periodontitis 44.91 12.81 25 28872 4471 79711020
Congenital coronary artery malformation 44.76 12.81 10 28887 106 79715385
Device failure 44.64 12.81 28 28869 6233 79709258
Periprosthetic fracture 43.99 12.81 14 28883 610 79714881
Electrocardiogram PR shortened 43.98 12.81 12 28885 303 79715188
Fibrocystic breast disease 43.01 12.81 14 28883 656 79714835
Pyelitis 42.97 12.81 12 28885 331 79715160
Resorption bone increased 42.35 12.81 17 28880 1458 79714033
Osteoarthritis 42.27 12.81 96 28801 87213 79628278
Injection site inflammation 42.17 12.81 23 28874 3953 79711538
Bone sequestrum 41.75 12.81 16 28881 1213 79714278
Groin pain 41.75 12.81 36 28861 13044 79702447
Drug abuse 41.67 12.81 5 28892 162686 79552805
Tooth loss 41.52 12.81 28 28869 7047 79708444
Loose tooth 41.51 12.81 21 28876 3096 79712395
Spinal osteoarthritis 41.16 12.81 40 28857 16887 79698604
Toothache 40.89 12.81 43 28854 19927 79695564
Product use in unapproved indication 40.57 12.81 20 28877 250339 79465152
Gingival swelling 39.00 12.81 23 28874 4586 79710905
Maternal exposure during pregnancy 38.11 12.81 3 28894 136535 79578956
Pelvic fracture 37.76 12.81 33 28864 12171 79703320
Exostosis 37.59 12.81 38 28859 16820 79698671
Treatment failure 37.48 12.81 8 28889 170478 79545013
Musculoskeletal pain 37.34 12.81 101 28796 102253 79613238
Bone density decreased 37.16 12.81 34 28863 13313 79702178
Febrile neutropenia 36.61 12.81 19 28878 230980 79484511
Hyperaesthesia teeth 35.47 12.81 16 28881 1830 79713661
Bladder hypertrophy 35.25 12.81 12 28885 647 79714844
Product use issue 35.16 12.81 16 28881 209806 79505685
Osteopenia 33.15 12.81 37 28860 18327 79697164
Hyperlipidaemia 33.13 12.81 44 28853 26049 79689442
Lower respiratory tract infection 33.02 12.81 4 28893 129216 79586275
Carcinoembryonic antigen increased 32.73 12.81 16 28881 2193 79713298
Spondylolisthesis 32.66 12.81 18 28879 3157 79712334
Dyspepsia 32.63 12.81 100 28797 108587 79606904
Hormone receptor positive HER2 negative breast cancer 32.59 12.81 8 28889 131 79715360
Multiple organ dysfunction syndrome 32.58 12.81 3 28894 120243 79595248
Calcification metastatic 32.48 12.81 8 28889 133 79715358
Renal cyst 32.46 12.81 33 28864 14699 79700792
Rib fracture 32.26 12.81 45 28852 27902 79687589
Hiatus hernia 32.23 12.81 41 28856 23271 79692220
Diverticulum 32.16 12.81 33 28864 14863 79700628
Hypotension 32.02 12.81 70 28827 440247 79275244
Spinal fracture 31.95 12.81 36 28861 18018 79697473
Metastases to lymph nodes 31.94 12.81 28 28869 10369 79705122
Drug intolerance 30.98 12.81 30 28867 264089 79451402
Oesophageal stenosis 29.86 12.81 19 28878 4335 79711156
Dental fistula 29.68 12.81 10 28887 522 79714969
Compression fracture 29.64 12.81 22 28875 6438 79709053
Osteomalacia 28.98 12.81 13 28884 1467 79714024
Jaw fistula 28.79 12.81 7 28890 110 79715381
Acute kidney injury 28.42 12.81 95 28802 519309 79196182
Radius fracture 28.11 12.81 17 28880 3547 79711944
Creatinine renal clearance increased 27.88 12.81 11 28886 902 79714589
Therapeutic product effect incomplete 26.69 12.81 9 28888 141636 79573855
Hip fracture 26.22 12.81 43 28854 30718 79684773
Lymphoedema 25.90 12.81 27 28870 12386 79703105
Chest pain 25.84 12.81 183 28714 282121 79433370
Pancreatic steatosis 25.47 12.81 11 28886 1134 79714357
Intentional overdose 25.37 12.81 4 28893 105956 79609535
Injection site swelling 25.26 12.81 54 28843 47078 79668413
Vertebral foraminal stenosis 25.07 12.81 11 28886 1178 79714313
Oesophagitis 24.95 12.81 37 28860 24252 79691239
Bone loss 24.89 12.81 14 28883 2553 79712938
Oral disorder 24.81 12.81 24 28873 10071 79705420
Rectocele 24.37 12.81 9 28888 616 79714875
Pulpitis dental 24.03 12.81 11 28886 1302 79714189
Bursitis 23.92 12.81 45 28852 35799 79679692
Intervertebral disc degeneration 23.81 12.81 29 28868 15756 79699735
COVID-19 23.48 12.81 14 28883 157660 79557831
Pain 23.32 12.81 371 28526 703431 79012060
Mucosal ulceration 23.15 12.81 12 28885 1861 79713630
Osteoporotic fracture 23.03 12.81 16 28881 4224 79711267
Synovitis 22.99 12.81 13 28884 150721 79564770
Scoliosis 22.72 12.81 20 28877 7444 79708047
Osteocalcin decreased 22.65 12.81 5 28892 50 79715441
Metastases to pleura 22.26 12.81 11 28886 1543 79713948
Osteogenesis imperfecta 22.16 12.81 8 28889 513 79714978
Thoracic vertebral fracture 22.13 12.81 17 28880 5236 79710255
Pneumonia 21.79 12.81 145 28752 660101 79055390
Purulence 21.52 12.81 12 28885 2153 79713338
Dental necrosis 21.40 12.81 6 28891 168 79715323
Gastritis 21.28 12.81 51 28846 47942 79667549
Tonsillar disorder 21.28 12.81 10 28887 1256 79714235
Haemorrhoids 21.25 12.81 38 28859 29090 79686401
Blood parathyroid hormone increased 21.09 12.81 14 28883 3431 79712060
Metastases to liver 20.73 12.81 37 28860 28277 79687214
Systemic lupus erythematosus 20.66 12.81 9 28888 121140 79594351
Dorsal ramus syndrome 20.53 12.81 4 28893 20 79715471
Confusional state 20.37 12.81 54 28843 317943 79397548
Breast mass 20.37 12.81 18 28879 6736 79708755
Tooth avulsion 20.20 12.81 5 28892 85 79715406
Joint swelling 20.06 12.81 47 28850 288599 79426892
Therapeutic product effect decreased 19.92 12.81 18 28879 163845 79551646
Induration 19.90 12.81 11 28886 1941 79713550
Oxygen saturation decreased 19.87 12.81 11 28886 129036 79586455
Dysphagia 19.62 12.81 92 28805 122044 79593447
Intentional product use issue 19.36 12.81 16 28881 152096 79563395
Hepatic enzyme increased 18.90 12.81 23 28874 182587 79532904
Ovarian cancer stage III 18.86 12.81 6 28891 261 79715230
Fractured sacrum 18.81 12.81 10 28887 1633 79713858
Barrett's oesophagus 18.75 12.81 8 28889 801 79714690
Wound haemorrhage 18.71 12.81 14 28883 4147 79711344
Uterine disorder 18.64 12.81 11 28886 2196 79713295
Breath odour 18.51 12.81 10 28887 1686 79713805
Cataract 18.49 12.81 57 28840 62063 79653428
Breast cancer 18.45 12.81 39 28858 33742 79681749
Meniscus injury 18.37 12.81 17 28880 6751 79708740
Atrophic vulvovaginitis 18.28 12.81 9 28888 1252 79714239
Muscle spasms 18.21 12.81 117 28780 174613 79540878
Eructation 18.03 12.81 21 28876 10888 79704603
Bone lesion excision 17.94 12.81 4 28893 42 79715449
Spondylolysis 17.93 12.81 5 28892 137 79715354
Lumbar vertebral fracture 17.84 12.81 17 28880 7005 79708486
Chest wall tumour 17.77 12.81 4 28893 44 79715447
Poor dental condition 17.70 12.81 7 28890 577 79714914
Musculoskeletal chest pain 17.67 12.81 32 28865 24732 79690759
Infusion site extravasation 17.62 12.81 20 28877 10088 79705403
Respiratory failure 17.47 12.81 24 28873 180887 79534604
Hypothyroidism 17.42 12.81 50 28847 52342 79663149
Cellulitis 17.40 12.81 82 28815 108978 79606513
Hypophosphataemic osteomalacia 17.10 12.81 6 28891 354 79715137
Chronic hepatic failure 16.98 12.81 8 28889 1011 79714480
Tooth infection 16.97 12.81 27 28870 18805 79696686
Injection site phlebitis 16.93 12.81 5 28892 169 79715322
Arterial thrombosis 16.69 12.81 11 28886 2663 79712828
Product dose omission issue 16.64 12.81 41 28856 247496 79467995
Sinus arrhythmia 16.48 12.81 10 28887 2100 79713391
Cardiac arrest 16.45 12.81 23 28874 172073 79543418
Intramedullary rod insertion 16.44 12.81 5 28892 187 79715304
Bone lesion 16.32 12.81 15 28882 5904 79709587
Phlebitis 16.30 12.81 18 28879 8812 79706679
Peritoneal disorder 16.15 12.81 7 28890 728 79714763
Suicide attempt 16.10 12.81 5 28892 82927 79632564
Pulmonary oedema 15.95 12.81 6 28891 88248 79627243
Blister 15.91 12.81 12 28885 119464 79596027
Helicobacter infection 15.88 12.81 3 28894 69701 79645790
Platelet count decreased 15.79 12.81 29 28868 194635 79520856
Lumbar spinal stenosis 15.77 12.81 14 28883 5268 79710223
Cardio-respiratory arrest 15.64 12.81 10 28887 108500 79606991
Nasopharyngitis 15.59 12.81 44 28853 253837 79461654
Cerumen impaction 15.41 12.81 8 28889 1244 79714247
X-ray of pelvis and hip abnormal 15.40 12.81 3 28894 15 79715476
Rotator cuff syndrome 15.24 12.81 22 28875 14073 79701418
Teeth brittle 15.18 12.81 6 28891 494 79714997
Stress urinary incontinence 15.06 12.81 9 28888 1837 79713654
Wrist fracture 14.97 12.81 20 28877 11901 79703590
Arteriosclerosis 14.89 12.81 25 28872 18202 79697289
Drug-induced liver injury 14.73 12.81 3 28894 66114 79649377
Death 14.65 12.81 133 28764 566381 79149110
Macular scar 14.62 12.81 4 28893 102 79715389
Skeletal injury 14.62 12.81 8 28889 1384 79714107
Osteoporosis 14.59 12.81 48 28849 54064 79661427
Hospitalisation 14.55 12.81 8 28889 94228 79621263
Lumbar radiculopathy 14.40 12.81 9 28888 1990 79713501
Hypercholesterolaemia 14.19 12.81 28 28869 23067 79692424
Breast disorder 14.07 12.81 9 28888 2072 79713419
Metastases to the mediastinum 14.03 12.81 6 28891 604 79714887
Therapy non-responder 14.02 12.81 8 28889 92297 79623194
Humerus fracture 13.87 12.81 17 28880 9296 79706195
Hand fracture 13.82 12.81 14 28883 6211 79709280
Comminuted fracture 13.72 12.81 6 28891 637 79714854
Tendonitis 13.58 12.81 28 28869 23802 79691689
Bone fragmentation 13.49 12.81 6 28891 664 79714827
Uterine leiomyoma 13.41 12.81 14 28883 6429 79709062
Injection site erythema 13.37 12.81 60 28837 78137 79637354
Injection site thrombosis 13.36 12.81 4 28893 142 79715349
Spinal stenosis 13.35 12.81 22 28875 15769 79699722
Oral surgery 13.33 12.81 7 28890 1114 79714377
Spinal meningeal cyst 13.33 12.81 3 28894 33 79715458
Rectal polyp 13.23 12.81 8 28889 1669 79713822
Tendon calcification 13.09 12.81 4 28893 152 79715339
Hypercalcaemia 13.09 12.81 37 28860 38393 79677098
Past-pointing 13.04 12.81 4 28893 154 79715337
Appendix disorder 13.03 12.81 8 28889 1716 79713775
Dental prosthesis user 13.01 12.81 3 28894 37 79715454
Jaw cyst 12.99 12.81 4 28893 156 79715335
Hypoxia 12.96 12.81 11 28886 103232 79612259

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M05BA06 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates
ATC M05BB09 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
FDA CS M0006519 Diphosphonates
FDA EPC N0000175579 Bisphosphonate
MeSH PA D050071 Bone Density Conservation Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypercalcemia indication 66931009 DOID:12678
Postmenopausal osteoporosis indication 102447009
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Bone pain contraindication 12584003
Heartburn contraindication 16331000
Esophagitis contraindication 16761005 DOID:11963
Swallowing painful contraindication 30233002
Ulcer of esophagus contraindication 30811009
Vitamin D deficiency contraindication 34713006
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Stricture of esophagus contraindication 63305008
Muscle pain contraindication 68962001
Fracture of femur contraindication 71620000
Duodenitis contraindication 72007001 DOID:8643
Bed-ridden contraindication 160685001
Acute peptic ulcer contraindication 196682000
Tooth disorder contraindication 234947003 DOID:1091
Esophageal dysmotility contraindication 266434009 DOID:9192
Primary malignant neoplasm contraindication 372087000
Aseptic necrosis of bone of jaw contraindication 441809006
Invasive Dental Procedure contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.98 acidic
pKa2 4.97 acidic
pKa3 9.03 acidic
pKa4 13.3 acidic
pKa5 7.94 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 150MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** BONIVA HOFFMANN LA ROCHE N021455 March 24, 2005 DISCN TABLET ORAL 7192938 May 6, 2023 TREATMENT AND PREVENTION OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN BY ONCE-MONTHLY ORAL ADMINISTRATION OF IBANDRONATE SODIUM MONOHYDRATE EQUIVALENT TO 150MG OF IBANDRONIC ACID
EQ 150MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** BONIVA HOFFMANN LA ROCHE N021455 March 24, 2005 DISCN TABLET ORAL 7410957 May 6, 2023 TREATMENT AND PREVENTION OF OSTEOPOROSIS
EQ 150MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** BONIVA HOFFMANN LA ROCHE N021455 March 24, 2005 DISCN TABLET ORAL 7718634 May 6, 2023 TREATMENT AND PREVENTION OF OSTEOPOROSIS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Farnesyl pyrophosphate synthase Enzyme INHIBITOR Ki 8.44 CHEMBL CHEMBL
Geranylgeranyl pyrophosphate synthase Enzyme IC50 4.10 CHEMBL
Squalene synthase Enzyme IC50 6.19 CHEMBL
Farnesyl pyrophosphate synthase Enzyme INHIBITOR IC50 5.13 IUPHAR

External reference:

IDSource
D08056 KEGG_DRUG
138926-19-9 SECONDARY_CAS_RN
4021407 VANDF
C0379200 UMLSCUI
BFQ PDB_CHEM_ID
CHEMBL997 ChEMBL_ID
CHEMBL3989569 ChEMBL_ID
CHEMBL1201008 ChEMBL_ID
DB00710 DRUGBANK_ID
D000077557 MESH_DESCRIPTOR_UI
60852 PUBCHEM_CID
3059 IUPHAR_LIGAND_ID
7189 INN_ID
UMD7G2653W UNII
115264 RXNORM
188271 MMSL
67270 MMSL
d05357 MMSL
007178 NDDF
007179 NDDF
395271007 SNOMEDCT_US
404839003 SNOMEDCT_US
420936009 SNOMEDCT_US
96287002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Boniva HUMAN PRESCRIPTION DRUG LABEL 1 0004-0186 TABLET, FILM COATED 150 mg ORAL NDA 27 sections
ibandronate sodium HUMAN PRESCRIPTION DRUG LABEL 1 25021-827 INJECTION, SOLUTION 3 mg INTRAVENOUS ANDA 30 sections
IBANDRONATE SODIUM Human Prescription Drug Label 1 33342-150 TABLET, FILM COATED 150 mg ORAL ANDA 27 sections
IBANDRONATE SODIUM Human Prescription Drug Label 1 33342-150 TABLET, FILM COATED 150 mg ORAL ANDA 27 sections
IBANDRONATE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 47781-103 TABLET 150 mg ORAL ANDA 27 sections
IBANDRONATE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 47781-103 TABLET 150 mg ORAL ANDA 27 sections
IBANDRONATE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 51224-008 INJECTION, SOLUTION 3 mg INTRAVENOUS ANDA 31 sections
IBANDRONATE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 51224-008 INJECTION, SOLUTION 3 mg INTRAVENOUS ANDA 31 sections
Boniva HUMAN PRESCRIPTION DRUG LABEL 1 54868-5322 TABLET, FILM COATED 150 mg ORAL NDA 28 sections
Ibandronate sodium HUMAN PRESCRIPTION DRUG LABEL 1 55111-575 TABLET 150 mg ORAL ANDA 26 sections
Ibandronate sodium HUMAN PRESCRIPTION DRUG LABEL 1 55111-575 TABLET 150 mg ORAL ANDA 26 sections
Ibandronate Sodium Human Prescription Drug Label 1 55150-191 INJECTION, SOLUTION 3 mg INTRAVENOUS ANDA 27 sections
Ibandronate Sodium Human Prescription Drug Label 1 55150-191 INJECTION, SOLUTION 3 mg INTRAVENOUS ANDA 27 sections
IBANDRONATE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 60429-643 TABLET, FILM COATED 150 mg ORAL ANDA 28 sections
IBANDRONATE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 60429-643 TABLET, FILM COATED 150 mg ORAL ANDA 28 sections
IBANDRONATE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 60505-2795 TABLET, FILM COATED 150 mg ORAL ANDA 28 sections
IBANDRONATE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 60505-2795 TABLET, FILM COATED 150 mg ORAL ANDA 28 sections
Ibandronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 60505-6097 INJECTION 3 mg INTRAVENOUS ANDA 28 sections
Ibandronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 60505-6097 INJECTION 3 mg INTRAVENOUS ANDA 28 sections
IBANDRONATE SODIUM Human Prescription Drug Label 1 62756-218 INJECTION, SOLUTION 3 mg INTRAVENOUS ANDA 28 sections
Ibandronate Sodium Human Prescription Drug Label 1 65862-237 TABLET, FILM COATED 150 mg ORAL ANDA 27 sections
Ibandronate Sodium Human Prescription Drug Label 1 65862-237 TABLET, FILM COATED 150 mg ORAL ANDA 27 sections
ibandronate sodium HUMAN PRESCRIPTION DRUG LABEL 1 67457-524 INJECTION, SOLUTION 3 mg INTRAVENOUS ANDA 23 sections
IBANDRONATE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 69452-378 TABLET 150 mg ORAL ANDA 27 sections