alendronic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium metabolism regulator, pharmaceutical aid 112 66376-36-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alendronate monosodium salt trihydrate
  • alendronate sodium trihydrate
  • alendronate sodium hydrate
  • alendronate
  • alendronic acid
  • alendronate sodium
  • aminohydroxybutane bisphosphonate
  • MK-217
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
  • Molecular weight: 249.10
  • Formula: C4H13NO7P2
  • CLOGP: -3.79
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 6
  • TPSA: 161.31
  • ALOGS: -1.17
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg O
10 mg O
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 45 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.68 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.33 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.22 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 29, 1995 FDA MERCK AND CO INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Femur fracture 6753.07 10.59 3844 372192 35451 55880580
Low turnover osteopathy 3041.57 10.59 1107 374929 2901 55913130
Osteonecrosis 2715.25 10.59 1777 374259 21438 55894593
Osteonecrosis of jaw 2308.89 10.59 1858 374178 31500 55884531
Pemphigus 2222.67 10.59 3858 372178 153354 55762677
Intramedullary rod insertion 2146.86 10.59 720 375316 1331 55914700
Systemic lupus erythematosus 1959.38 10.59 3950 372086 176128 55739903
Glossodynia 1857.34 10.59 3508 372528 148950 55767081
Stress fracture 1494.74 10.59 798 375238 6379 55909652
Hand deformity 1359.92 10.59 2864 373172 131628 55784403
Atypical femur fracture 1352.18 10.59 665 375371 4382 55911649
Arthropathy 1256.81 10.59 3548 372488 196727 55719304
Abdominal discomfort 1222.85 10.59 4348 371688 272926 55643105
Wound 1189.97 10.59 2767 373269 136037 55779994
Fracture nonunion 1150.79 10.59 465 375571 1762 55914269
Osteoarthritis 1131.97 10.59 1970 374066 78326 55837705
Alopecia 1085.21 10.59 4350 371686 289108 55626923
Open reduction of fracture 992.54 10.59 348 375688 783 55915248
Dental caries 950.34 10.59 678 375358 9490 55906541
Pericarditis 950.28 10.59 2187 373849 106736 55809295
Osteomyelitis 940.06 10.59 978 375058 23368 55892663
Toxicity to various agents 932.32 10.59 184 375852 224380 55691651
Anaemia postoperative 900.36 10.59 387 375649 1774 55914257
Anti-cyclic citrullinated peptide antibody positive 869.12 10.59 1988 374048 96612 55819419
Impaired healing 865.00 10.59 1839 374197 85002 55831029
Hyperlipidaemia 849.91 10.59 809 375227 17300 55898731
Death 833.60 10.59 638 375398 340788 55575243
Discomfort 830.80 10.59 2452 373584 139309 55776722
Nausea 772.79 10.59 2580 373456 761598 55154433
Tooth disorder 764.34 10.59 898 375138 24655 55891376
Completed suicide 715.47 10.59 45 375991 133788 55782243
Swelling 714.43 10.59 3332 372704 236439 55679592
Diarrhoea 705.95 10.59 2069 373967 636438 55279593
Contraindicated product administered 690.02 10.59 2765 373271 183521 55732510
Spinal osteoarthritis 647.68 10.59 637 375399 14199 55901832
Jaw disorder 645.50 10.59 410 375626 4673 55911358
Osteopenia 633.53 10.59 691 375345 17450 55898581
Duodenal ulcer perforation 624.27 10.59 1398 374638 66944 55849087
Vomiting 621.33 10.59 1520 374516 496708 55419323
Osteoporosis 614.15 10.59 1183 374853 50869 55865162
Oral infection 609.35 10.59 378 375658 4120 55911911
Synovitis 597.76 10.59 2395 373641 158910 55757121
Helicobacter infection 585.25 10.59 1422 374614 71846 55844185
Product dose omission issue 553.12 10.59 342 375694 204411 55711620
Vitamin D deficiency 550.83 10.59 533 375503 11637 55904394
Bone disorder 537.21 10.59 658 375378 18885 55897146
Neutropenia 522.99 10.59 201 375835 157966 55758065
Hypercholesterolaemia 513.60 10.59 556 375480 13917 55902114
Gastrooesophageal reflux disease 511.19 10.59 1465 374571 81792 55834239
Infusion related reaction 499.00 10.59 2729 373307 206202 55709829
Foot fracture 492.26 10.59 666 375370 21143 55894888
Intervertebral disc degeneration 490.86 10.59 539 375497 13715 55902316
Rheumatoid arthritis 488.57 10.59 4284 371752 378320 55537711
Off label use 485.64 10.59 1992 374044 554188 55361843
Acute kidney injury 475.05 10.59 545 375491 240218 55675813
Blood cholesterol increased 469.90 10.59 1302 374734 71277 55844754
Tooth fracture 463.10 10.59 449 375587 9827 55906204
Bursitis 459.67 10.59 730 375306 26852 55889179
Fracture delayed union 446.41 10.59 246 375790 2107 55913924
Rheumatoid factor positive 446.22 10.59 1238 374798 67822 55848209
Exostosis of jaw 443.98 10.59 199 375837 1028 55915003
Febrile neutropenia 440.73 10.59 85 375951 105460 55810571
Temporomandibular joint syndrome 436.00 10.59 286 375750 3458 55912573
Device failure 434.86 10.59 335 375701 5304 55910727
Drug interaction 434.48 10.59 456 375580 209299 55706732
Maternal exposure during pregnancy 411.60 10.59 2414 373622 187139 55728892
Intentional overdose 407.11 10.59 10 376026 68107 55847924
Hypotension 397.94 10.59 663 375373 249845 55666186
Hip arthroplasty 395.91 10.59 828 375208 37795 55878236
Hepatic enzyme increased 393.22 10.59 2215 373821 169169 55746862
Gingival disorder 389.09 10.59 255 375781 3078 55912953
Adverse event 378.97 10.59 1014 375022 54362 55861669
Knee arthroplasty 378.14 10.59 882 375154 43377 55872654
Pathological fracture 373.10 10.59 358 375678 7731 55908300
Medical device removal 366.62 10.59 173 375863 1026 55915005
Disease progression 362.21 10.59 125 375911 105048 55810983
Drug abuse 357.45 10.59 24 376012 67586 55848445
Headache 353.56 10.59 2238 373798 556806 55359225
Periodontal disease 352.57 10.59 182 375854 1346 55914685
Scoliosis 333.40 10.59 314 375722 6619 55909412
Exostosis 332.16 10.59 453 375583 14490 55901541
Spondylolisthesis 326.68 10.59 229 375807 3110 55912921
Product use issue 319.62 10.59 2233 373803 183808 55732223
Bone density decreased 319.37 10.59 410 375626 12350 55903681
Internal fixation of fracture 315.07 10.59 131 375905 543 55915488
Diverticulum 311.27 10.59 377 375659 10689 55905342
COVID-19 307.97 10.59 63 375973 74995 55841036
Calcium deficiency 302.57 10.59 144 375892 873 55915158
Suicide attempt 301.48 10.59 22 376014 57814 55858217
Bone loss 299.51 10.59 207 375829 2744 55913287
Drug intolerance 298.72 10.59 2889 373147 261929 55654102
Tooth extraction 297.83 10.59 342 375694 9151 55906880
Rib fracture 297.24 10.59 507 375529 19802 55896229
Thrombocytopenia 295.80 10.59 284 375752 135940 55780091
Dyspnoea 291.51 10.59 2546 373490 590031 55326000
Injection site pain 290.08 10.59 215 375821 116903 55799128
Malignant neoplasm progression 287.32 10.59 69 375967 73518 55842513
Asthenia 285.79 10.59 1249 374787 341724 55574307
Malaise 279.17 10.59 1386 374650 366474 55549557
Irritable bowel syndrome 276.38 10.59 1045 374991 67413 55848618
Tooth loss 274.54 10.59 271 375765 6066 55909965
Spinal compression fracture 272.23 10.59 385 375651 12749 55903282
Lumbar spinal stenosis 265.45 10.59 227 375809 4196 55911835
Pyrexia 263.49 10.59 1678 374358 417095 55498936
Hip fracture 262.24 10.59 566 375470 26407 55889624
White blood cell count decreased 261.70 10.59 273 375763 125717 55790314
Jaw fracture 255.23 10.59 176 375860 2324 55913707
Cardiac arrest 253.20 10.59 130 375906 86184 55829847
Rotator cuff syndrome 251.76 10.59 356 375680 11787 55904244
Rheumatic fever 246.77 10.59 575 375461 28252 55887779
Abortion spontaneous 242.07 10.59 12 376024 43741 55872290
Muscle injury 239.50 10.59 834 375202 51666 55864365
Hypersensitivity 236.55 10.59 2686 373350 253722 55662309
Seizure 236.07 10.59 293 375743 124826 55791205
Resorption bone increased 235.25 10.59 130 375906 1120 55914911
Kyphosis 234.87 10.59 162 375874 2140 55913891
Periodontitis 233.23 10.59 183 375853 2980 55913051
Type 2 diabetes mellitus 231.87 10.59 765 375271 46097 55869934
Loose tooth 231.72 10.59 185 375851 3093 55912938
Radius fracture 225.49 10.59 182 375854 3093 55912938
Basal cell carcinoma 223.51 10.59 510 375526 24711 55891320
Swollen joint count increased 223.21 10.59 497 375539 23687 55892344
Platelet count decreased 222.63 10.59 229 375807 106154 55809877
Fall 221.89 10.59 3485 372551 354025 55562006
Large intestine polyp 221.32 10.59 264 375772 7363 55908668
Blood parathyroid hormone decreased 220.80 10.59 276 375760 8088 55907943
Folliculitis 218.38 10.59 835 375201 54144 55861887
Bone graft 217.16 10.59 110 375926 778 55915253
Muscle strain 214.78 10.59 258 375778 7250 55908781
Blood loss anaemia 213.00 10.59 270 375766 8027 55908004
Feeling abnormal 209.67 10.59 356 375680 133246 55782785
Oral disorder 206.66 10.59 264 375772 7911 55908120
Fibrocystic breast disease 202.99 10.59 113 375923 989 55915042
Foetal exposure during pregnancy 201.95 10.59 5 376031 33818 55882213
Pneumonia 201.51 10.59 1745 374291 405353 55510678
Granuloma skin 201.22 10.59 242 375794 6809 55909222
Hyperhidrosis 199.75 10.59 200 375836 93888 55822143
Sepsis 199.54 10.59 395 375641 139445 55776586
Blister 198.69 10.59 1327 374709 107560 55808471
Tonsillar disorder 198.68 10.59 111 375925 979 55915052
Tooth abscess 198.28 10.59 340 375696 13335 55902696
Pelvic fracture 197.63 10.59 319 375717 11894 55904137
Limb asymmetry 196.89 10.59 101 375935 736 55915295
Sleep disorder due to general medical condition, insomnia type 194.67 10.59 685 375351 42653 55873378
Gingivitis 193.38 10.59 248 375788 7461 55908570
Wrist fracture 193.09 10.59 313 375723 11713 55904318
Somnolence 192.43 10.59 512 375524 162901 55753130
Lumbar radiculopathy 191.67 10.59 132 375904 1739 55914292
Tonsillectomy 191.15 10.59 97 375939 689 55915342
Oral cavity fistula 190.35 10.59 91 375945 558 55915473
Psoriasis 190.03 10.59 203 375833 92489 55823542
Edentulous 189.97 10.59 70 375966 192 55915839
Ulna fracture 189.44 10.59 106 375930 938 55915093
Panniculitis 188.63 10.59 278 375758 9564 55906467
Cerumen impaction 188.62 10.59 105 375931 919 55915112
Cardio-respiratory arrest 186.56 10.59 68 375968 55253 55860778
Injection site erythema 184.32 10.59 148 375888 77300 55838731
Tibia fracture 183.22 10.59 190 375846 4518 55911513
Electrocardiogram QT prolonged 180.90 10.59 69 375967 54519 55861512
Dizziness 177.86 10.59 1631 374405 374509 55541522
Pancytopenia 177.77 10.59 198 375838 88517 55827514
Hospitalisation 177.64 10.59 144 375892 74856 55841175
Hypertension 176.35 10.59 2445 373591 241833 55674198
Abdominal pain 174.51 10.59 1014 375022 257791 55658240
Therapeutic product effect decreased 172.62 10.59 1811 374225 167641 55748390
Meniscus injury 172.47 10.59 216 375820 6342 55909689
Uterine disorder 172.03 10.59 147 375889 2714 55913317
Anaphylactic reaction 171.31 10.59 90 375946 58905 55857126
Tremor 170.19 10.59 345 375691 120744 55795287
Premature delivery 165.51 10.59 3 376033 27057 55888974
Fistula discharge 164.69 10.59 95 375941 896 55915135
Flushing 164.27 10.59 136 375900 69964 55846067
Wrong technique in product usage process 164.14 10.59 92 375944 58076 55857955
Weight decreased 163.40 10.59 941 375095 239773 55676258
Atypical fracture 163.01 10.59 80 375956 524 55915507
Fibula fracture 161.31 10.59 149 375887 3061 55912970
Intentional product misuse 161.11 10.59 71 375965 51433 55864598
Rheumatoid nodule 161.03 10.59 326 375710 14531 55901500
Cough 160.95 10.59 1046 374990 258915 55657116
Loss of consciousness 159.33 10.59 305 375731 109044 55806987
Stress urinary incontinence 157.28 10.59 124 375912 2034 55913997
Patellofemoral pain syndrome 156.06 10.59 77 375959 511 55915520
Pain 154.15 10.59 5641 370395 657543 55258488
Depressed level of consciousness 153.92 10.59 93 375943 56340 55859691
Leukopenia 151.48 10.59 150 375886 70790 55845241
Mitral valve prolapse 150.62 10.59 122 375914 2084 55913947
Dehydration 149.95 10.59 550 375486 158275 55757756
Ligament sprain 149.19 10.59 272 375764 11203 55904828
Neutrophil count decreased 149.16 10.59 73 375963 49749 55866282
Multiple organ dysfunction syndrome 148.13 10.59 84 375952 52686 55863345
Periprosthetic fracture 146.24 10.59 68 375968 388 55915643
Drug tolerance decreased 146.22 10.59 295 375741 13116 55902915
Osteitis 145.47 10.59 140 375896 3034 55912997
Synovial cyst 145.47 10.59 238 375798 8976 55907055
Hiatus hernia 143.71 10.59 369 375667 19283 55896748
Cataract 143.21 10.59 700 375336 50547 55865484
Tachycardia 142.60 10.59 309 375727 105567 55810464
Overdose 142.43 10.59 309 375727 105521 55810510
Fracture displacement 142.09 10.59 92 375944 1086 55914945
Lactic acidosis 140.22 10.59 32 376004 35314 55880717
Joint swelling 139.98 10.59 2715 373321 287085 55628946
Removal of internal fixation 139.81 10.59 42 375994 42 55915989
Tendonitis 138.80 10.59 346 375690 17751 55898280
Cataract operation 137.89 10.59 165 375871 4617 55911414
Sedation 137.38 10.59 32 376004 34822 55881209
Haemorrhoids 137.15 10.59 369 375667 19837 55896194
Respiratory arrest 135.82 10.59 21 376015 30604 55885427
Pulmonary embolism 135.07 10.59 324 375712 106800 55809231
Dental fistula 134.90 10.59 71 375965 549 55915482
Appendix disorder 133.95 10.59 96 375940 1353 55914678
Exposed bone in jaw 133.14 10.59 127 375909 2721 55913310
Dental necrosis 132.87 10.59 46 375990 98 55915933
Skin necrosis 132.50 10.59 270 375766 12091 55903940
Mucosal inflammation 132.35 10.59 60 375976 42750 55873281
Abscess jaw 131.86 10.59 93 375943 1276 55914755
Appendicectomy 131.58 10.59 123 375913 2567 55913464
Ulcer 131.45 10.59 389 375647 22096 55893935
Neoplasm progression 131.04 10.59 27 376009 31989 55884042
Respiratory failure 130.89 10.59 274 375762 94788 55821243
Intentional self-injury 128.83 10.59 10 376026 24982 55891049
Hypothyroidism 128.47 10.59 551 375485 37645 55878386
Cardiac murmur 128.15 10.59 254 375782 11147 55904884
Cystocele 127.11 10.59 84 375952 1029 55915002
Drug reaction with eosinophilia and systemic symptoms 125.19 10.59 25 376011 30279 55885752
Agitation 124.88 10.59 114 375922 55922 55860109
Atrophic vulvovaginitis 124.42 10.59 97 375939 1564 55914467
Unevaluable event 124.00 10.59 83 375953 47604 55868427
Dental implantation 123.52 10.59 68 375968 581 55915450
Hypercalcaemia 123.15 10.59 412 375624 24999 55891032
Cognitive disorder 123.14 10.59 89 375947 49044 55866987
Adverse drug reaction 123.13 10.59 801 375235 64331 55851700
Breast disorder 121.46 10.59 111 375925 2248 55913783
Injection site swelling 121.41 10.59 70 375966 43508 55872523
Therapeutic product effect incomplete 121.16 10.59 337 375699 105694 55810337
Suicidal ideation 119.96 10.59 125 375911 57617 55858414
Hyperaesthesia teeth 119.63 10.59 94 375942 1534 55914497
Femoral neck fracture 116.34 10.59 196 375840 7575 55908456
Varicose vein 116.24 10.59 149 375887 4480 55911551
Urticaria 114.73 10.59 536 375500 144140 55771891
Fractured sacrum 114.63 10.59 97 375939 1766 55914265
Multiple sclerosis relapse 114.29 10.59 80 375956 44823 55871208
Renal failure 114.18 10.59 368 375668 110132 55805899
Illness 113.71 10.59 44 375992 34467 55881564
Intervertebral disc protrusion 113.47 10.59 361 375675 21333 55894698
Abscess 113.21 10.59 286 375750 14795 55901236
Oestrogen deficiency 112.50 10.59 42 375994 121 55915910
Seborrhoeic keratosis 112.22 10.59 97 375939 1820 55914211
Renal impairment 110.81 10.59 233 375803 80480 55835551
Blood pressure increased 110.37 10.59 546 375490 144630 55771401
Vertebral foraminal stenosis 110.02 10.59 70 375966 800 55915231
Metabolic acidosis 109.85 10.59 67 375969 40387 55875644
Drug resistance 109.42 10.59 7 376029 20535 55895496
Joint effusion 109.20 10.59 280 375756 14618 55901413
Sopor 108.90 10.59 8 376028 20914 55895117
Therapy interrupted 108.27 10.59 20 376016 25605 55890426
Plasma cell myeloma 107.43 10.59 92 375944 46554 55869477
Compression fracture 107.40 10.59 164 375872 5825 55910206
Hysterectomy 107.11 10.59 200 375836 8391 55907640
Accidental exposure to product 106.83 10.59 18 376018 24629 55891402
Septic shock 105.98 10.59 151 375885 60684 55855347
Decreased appetite 105.43 10.59 946 375090 218285 55697746
Periodontal operation 105.12 10.59 29 376007 14 55916017
Jaw operation 104.41 10.59 67 375969 778 55915253
Blood glucose increased 103.12 10.59 217 375819 74934 55841097
Humerus fracture 102.83 10.59 190 375846 7907 55908124
Spinal fracture 102.61 10.59 291 375745 16133 55899898
Arthritis 102.44 10.59 1069 374967 98783 55817248
Encephalopathy 102.38 10.59 54 375982 35271 55880760
Chills 102.36 10.59 347 375689 102257 55813774
Haemoglobin decreased 101.67 10.59 505 375531 133632 55782399
Radiculopathy 101.41 10.59 155 375881 5510 55910521
Pulpitis dental 100.88 10.59 66 375970 794 55915237
Pruritus 100.83 10.59 1498 374538 315125 55600906
Bone lesion 100.65 10.59 151 375885 5279 55910752
Drug ineffective for unapproved indication 100.45 10.59 24 376012 25669 55890362
Fistula 100.39 10.59 198 375838 8657 55907374
Arthralgia 100.16 10.59 4199 371837 497470 55418561
Anaemia 99.11 10.59 1227 374809 266284 55649747
Foot deformity 98.84 10.59 367 375669 23458 55892573
Drug ineffective 98.60 10.59 5080 370956 913909 55002122
Liver injury 98.49 10.59 545 375491 41303 55874728
Influenza like illness 97.95 10.59 160 375876 60828 55855203
Feeling hot 96.74 10.59 82 375954 41705 55874326
Bradycardia 95.95 10.59 191 375845 67313 55848718
Oxygen saturation decreased 95.85 10.59 244 375792 78823 55837208
Chest discomfort 95.46 10.59 339 375697 98518 55817513
Oral surgery 95.37 10.59 70 375966 1026 55915005
Blood creatinine increased 95.27 10.59 250 375786 79941 55836090
Patella fracture 94.12 10.59 88 375948 1837 55914194
Carotid bruit 94.02 10.59 57 375979 594 55915437
Oesophagitis 93.69 10.59 255 375781 13802 55902229
Abdominal pain upper 92.16 10.59 755 375281 177558 55738473
Vascular calcification 92.02 10.59 59 375977 684 55915347
Treatment failure 91.74 10.59 1624 374412 168768 55747263
Osteomyelitis chronic 91.68 10.59 47 375989 342 55915689
Hepatic failure 91.57 10.59 55 375981 33431 55882600
Skin discolouration 90.40 10.59 59 375977 34297 55881734
Caesarean section 90.34 10.59 4 376032 16087 55899944
Abscess oral 90.14 10.59 77 375959 1421 55914610
Injection site reaction 89.97 10.59 135 375901 53112 55862919
Hepatotoxicity 89.73 10.59 48 375988 31105 55884926
Dyslipidaemia 89.54 10.59 156 375880 6197 55909834
Essential hypertension 89.13 10.59 132 375904 4561 55911470
Disturbance in attention 88.20 10.59 54 375982 32486 55883545
Fracture 88.08 10.59 293 375743 17725 55898306
Contusion 87.90 10.59 1274 374762 127156 55788875
Gingival recession 87.73 10.59 72 375964 1254 55914777
Product use in unapproved indication 87.34 10.59 566 375470 140256 55775775
Injection site pruritus 86.84 10.59 91 375945 41840 55874191
Injection site bruising 86.26 10.59 78 375958 38443 55877588
Depressed mood 85.84 10.59 70 375966 36289 55879742
Ankle fracture 85.82 10.59 273 375763 16130 55899901
Endodontic procedure 85.80 10.59 102 375934 2834 55913197
Gastrointestinal disorder 85.64 10.59 1139 374897 111563 55804468
Hepatocellular injury 85.39 10.59 35 376001 26479 55889552
Fracture malunion 85.34 10.59 35 376001 139 55915892
Lower limb fracture 85.33 10.59 286 375750 17369 55898662
Peptic ulcer 85.17 10.59 121 375915 4023 55912008
Drug withdrawal syndrome 85.13 10.59 33 376003 25824 55890207
Hand fracture 84.92 10.59 134 375902 4899 55911132
Rhinitis allergic 84.86 10.59 180 375856 8294 55907737
Alveolar osteitis 84.73 10.59 51 375985 524 55915507
Extraskeletal ossification 84.40 10.59 31 376005 84 55915947
Toxic epidermal necrolysis 83.44 10.59 22 376014 22020 55894011
Osteopetrosis 83.44 10.59 23 376013 11 55916020
Rash erythematous 82.60 10.59 76 375960 37145 55878886
Oroantral fistula 82.36 10.59 35 376001 155 55915876
Gingival bleeding 82.16 10.59 216 375820 11450 55904581
Rectocele 82.09 10.59 61 375975 912 55915119
Serotonin syndrome 82.08 10.59 37 375999 26453 55889578
Pulmonary oedema 81.35 10.59 135 375901 51008 55865023
Generalised tonic-clonic seizure 80.09 10.59 42 375994 27524 55888507
Clostridium difficile infection 79.68 10.59 41 375995 27157 55888874
Spinal laminectomy 79.24 10.59 52 375984 629 55915402
Fluid retention 78.59 10.59 151 375885 53927 55862104
Ascites 78.29 10.59 81 375955 37463 55878568
Iliotibial band syndrome 77.55 10.59 34 376002 165 55915866
Myelosuppression 77.33 10.59 12 376024 17443 55898588
Epistaxis 77.31 10.59 212 375824 66811 55849220
Cardiac failure 76.95 10.59 285 375751 81808 55834223
Restlessness 76.52 10.59 41 375995 26545 55889486
Acute sinusitis 76.48 10.59 107 375929 3506 55912525
Dental plaque 76.10 10.59 29 376007 90 55915941
Osteoradionecrosis 75.40 10.59 29 376007 93 55915938
Posterior reversible encephalopathy syndrome 75.38 10.59 9 376027 15951 55900080
Cholestasis 75.29 10.59 43 375993 26870 55889161
Bone marrow failure 75.21 10.59 48 375988 28238 55887793
Anaphylactic shock 74.52 10.59 26 376010 21714 55894317
Neuropathy peripheral 74.20 10.59 394 375642 102499 55813532
Sciatica 73.88 10.59 357 375679 25653 55890378
Bone metabolism disorder 73.73 10.59 40 375996 331 55915700
Erythema 73.56 10.59 676 375360 155263 55760768
Angioedema 73.08 10.59 102 375934 41351 55874680
Pain in jaw 72.99 10.59 488 375548 39548 55876483
Arthroscopy 72.77 10.59 48 375988 586 55915445
Road traffic accident 72.73 10.59 374 375662 27553 55888478
Oropharyngeal pain 72.71 10.59 300 375736 83488 55832543
Aortic arteriosclerosis 72.61 10.59 133 375903 5497 55910534
Abdominal distension 72.43 10.59 270 375766 77356 55838675
Tooth deposit 72.00 10.59 34 376002 202 55915829
Influenza 71.95 10.59 359 375677 94902 55821129
Creatinine renal clearance decreased 71.85 10.59 7 376029 14552 55901479
Carpal tunnel syndrome 71.54 10.59 275 375761 17869 55898162
Lumbosacral radiculopathy 71.46 10.59 39 375997 327 55915704
Paraesthesia 71.40 10.59 544 375492 129970 55786061
Spinal stenosis 71.29 10.59 231 375805 13783 55902248
Diabetic ketoacidosis 71.12 10.59 19 376017 18852 55897179
Acetabulum fracture 70.91 10.59 36 376000 256 55915775
No adverse event 70.86 10.59 83 375953 36291 55879740
Memory impairment 70.77 10.59 317 375719 86240 55829791
Neutropenic sepsis 70.65 10.59 9 376027 15176 55900855
Therapy cessation 70.14 10.59 48 375988 27216 55888815
Biopsy bone 69.81 10.59 23 376013 39 55915992
Joint dislocation 69.68 10.59 248 375788 15525 55900506
Closed fracture manipulation 68.98 10.59 19 376017 9 55916022
Acquired oesophageal web 68.90 10.59 32 376004 182 55915849
Oedema mouth 68.74 10.59 81 375955 2229 55913802
Irritability 68.57 10.59 58 375978 29530 55886501
Incorrect dose administered 68.56 10.59 156 375880 52391 55863640
Peripheral vascular disorder 68.55 10.59 131 375905 5594 55910437
Transaminases increased 68.40 10.59 55 375981 28715 55887316
Spinal disorder 68.35 10.59 170 375866 8708 55907323
Red blood cell sedimentation rate abnormal 68.14 10.59 20 376016 18653 55897378
Status epilepticus 68.02 10.59 10 376026 15131 55900900
Hyperkalaemia 68.00 10.59 149 375887 50716 55865315
Product quality issue 67.85 10.59 67 375969 31669 55884362
Nasal septum deviation 67.79 10.59 62 375974 1257 55914774
Device issue 67.75 10.59 28 376008 21078 55894953
Haemorrhage 67.61 10.59 175 375861 56222 55859809
Palmar-plantar erythrodysaesthesia syndrome 67.53 10.59 28 376008 21037 55894994
Breast conserving surgery 67.19 10.59 53 375983 870 55915161
Vision blurred 67.07 10.59 305 375731 82638 55833393
Dry skin 66.33 10.59 134 375902 46975 55869056
Dyskinesia 66.31 10.59 58 375978 29050 55886981
Skin ulcer 65.88 10.59 463 375573 38145 55877886
Jaw cyst 65.68 10.59 27 376009 108 55915923
Neurotoxicity 65.30 10.59 13 376023 15782 55900249
Pleural effusion 65.21 10.59 321 375715 85159 55830872
Actinomycosis 64.92 10.59 54 375982 959 55915072
Burning sensation 64.81 10.59 143 375893 48553 55867478
Nasal congestion 64.49 10.59 179 375857 56191 55859840
Blood pressure decreased 64.27 10.59 192 375844 58858 55857173
Adenotonsillectomy 64.26 10.59 20 376016 25 55916006
Heart rate increased 63.94 10.59 312 375724 82961 55833070
Skeletal injury 63.66 10.59 57 375979 1123 55914908
Abnormal behaviour 63.30 10.59 28 376008 20244 55895787
Trismus 63.19 10.59 97 375939 3461 55912570
Epilepsy 62.83 10.59 46 375990 25185 55890846
Psychotic disorder 62.60 10.59 40 375996 23518 55892513
Eustachian tube dysfunction 62.45 10.59 36 376000 339 55915692
Bone formation decreased 62.44 10.59 23 376013 63 55915968
Renal cyst 62.16 10.59 169 375867 9140 55906891
Pericardial effusion 62.08 10.59 54 375982 27121 55888910
Gastritis 62.07 10.59 421 375615 34281 55881750
Aggression 61.79 10.59 35 376001 21971 55894060
Disorientation 61.68 10.59 93 375943 36520 55879511
Bruxism 61.49 10.59 90 375946 3076 55912955
Type V hyperlipidaemia 61.28 10.59 39 375997 446 55915585
Drug level increased 61.07 10.59 31 376005 20694 55895337
Skin exfoliation 60.95 10.59 95 375941 36805 55879226
Blood bilirubin increased 60.89 10.59 80 375956 33274 55882757
Carotid artery stenosis 60.83 10.59 114 375922 4796 55911235
Dysarthria 60.52 10.59 107 375929 39443 55876588
Osteoma 60.50 10.59 19 376017 25 55916006
Polymyalgia rheumatica 60.43 10.59 88 375948 2994 55913037
Angiopathy 60.37 10.59 105 375931 4165 55911866
Bone fragmentation 60.27 10.59 45 375991 678 55915353
Rhinorrhoea 60.26 10.59 188 375848 56849 55859182
Unresponsive to stimuli 60.09 10.59 74 375962 31651 55884380
Cytomegalovirus infection 59.71 10.59 27 376009 19269 55896762
Breast calcifications 59.69 10.59 55 375981 1126 55914905
Anaemia of chronic disease 59.60 10.59 68 375968 1806 55914225
Lacrimation increased 59.45 10.59 24 376012 18324 55897707
Tenosynovitis stenosans 59.23 10.59 80 375956 2534 55913497
Nocturia 58.90 10.59 140 375896 6966 55909065
Hepatitis 58.77 10.59 91 375945 35350 55880681
Hypervolaemia 58.73 10.59 54 375982 26404 55889627
Pancreatitis 58.67 10.59 134 375902 44946 55871085
Hypertonic bladder 58.66 10.59 89 375947 3143 55912888
Inappropriate schedule of product administration 58.63 10.59 322 375714 83065 55832966
Intervertebral disc disorder 58.48 10.59 107 375929 4419 55911612
Withdrawal syndrome 58.44 10.59 25 376011 18437 55897594
Acute hepatic failure 58.26 10.59 19 376017 16559 55899472
Actinic keratosis 57.83 10.59 74 375962 2221 55913810
Arteriosclerosis coronary artery 57.52 10.59 147 375889 7658 55908373
Vaginal haemorrhage 57.46 10.59 52 375984 25621 55890410
Lymphocyte count decreased 57.44 10.59 61 375975 27878 55888153
Bone sequestrum 57.30 10.59 58 375978 1339 55914692
Colitis 57.12 10.59 121 375915 41690 55874341
Red blood cell count decreased 57.00 10.59 98 375938 36519 55879512
Kyphoscoliosis 56.32 10.59 36 376000 415 55915616
Shock 56.24 10.59 38 375998 21690 55894341
Urinary tract infection 56.09 10.59 1202 374834 239311 55676720
Urge incontinence 55.96 10.59 46 375990 803 55915228
Peripheral venous disease 55.73 10.59 171 375865 9908 55906123
Constipation 55.69 10.59 981 375055 200962 55715069
COVID-19 pneumonia 55.69 10.59 5 376031 11097 55904934
Postmenopause 55.67 10.59 19 376017 38 55915993
Debridement 55.62 10.59 53 375983 1134 55914897
Infusion site pain 55.51 10.59 12 376024 13750 55902281
Hyperparathyroidism 55.22 10.59 77 375959 2515 55913516
Intraocular lens implant 55.02 10.59 30 376006 251 55915780
Crying 54.82 10.59 38 375998 21402 55894629
Chronic obstructive pulmonary disease 54.81 10.59 606 375430 56809 55859222
Altered state of consciousness 54.74 10.59 44 375992 22977 55893054
Osteonecrosis of external auditory canal 54.71 10.59 22 376014 82 55915949
Dysgeusia 54.57 10.59 120 375916 40795 55875236
Heavy menstrual bleeding 54.51 10.59 20 376016 16189 55899842
Aphasia 54.46 10.59 74 375962 30341 55885690
Rhabdomyolysis 54.43 10.59 119 375917 40539 55875492
Cytokine release syndrome 54.27 10.59 5 376031 10870 55905161
Muscle spasticity 54.27 10.59 33 376003 19927 55896104
Biopsy breast 54.14 10.59 30 376006 260 55915771
Hypoglycaemia 54.13 10.59 191 375845 55624 55860407
Poisoning 54.13 10.59 10 376026 12803 55903228
Mood swings 54.10 10.59 22 376014 16725 55899306
Thoracic vertebral fracture 54.09 10.59 100 375936 4163 55911868
Atrophy 54.06 10.59 59 375977 1490 55914541
Pallor 53.95 10.59 49 375987 24100 55891931
Spinal meningeal cyst 53.75 10.59 18 376018 33 55915998
Heart rate decreased 53.57 10.59 119 375917 40308 55875723
Pulmonary arterial hypertension 53.23 10.59 59 375977 26444 55889587
Sequestrectomy 53.20 10.59 44 375992 775 55915256
Drug eruption 53.12 10.59 324 375712 25439 55890592
Rash maculo-papular 53.11 10.59 69 375967 28838 55887193
Coronary artery disease 52.94 10.59 370 375666 30426 55885605
Mydriasis 52.89 10.59 6 376030 11065 55904966
Injection site mass 52.74 10.59 23 376013 16770 55899261
Thrombosis 52.67 10.59 211 375825 59216 55856815
Disease recurrence 52.61 10.59 49 375987 23811 55892220
Myoclonus 52.42 10.59 18 376018 15185 55900846
Pneumonitis 52.38 10.59 81 375955 31483 55884548
Psoriatic arthropathy 52.13 10.59 738 375298 73270 55842761
Schizophrenia 51.94 10.59 5 376031 10494 55905537
Body height decreased 51.88 10.59 157 375879 9028 55907003
Carotid artery disease 51.44 10.59 58 375978 1520 55914511
Full blood count decreased 51.42 10.59 48 375988 23301 55892730
Diverticulum intestinal 51.36 10.59 125 375911 6315 55909716
Steroid therapy 51.35 10.59 20 376016 67 55915964
Oesophageal ulcer 51.15 10.59 96 375940 4043 55911988
Pernicious anaemia 50.96 10.59 39 375997 611 55915420
Respiratory distress 49.98 10.59 84 375952 31583 55884448
Lung neoplasm 49.76 10.59 112 375924 5375 55910656
Toothache 49.76 10.59 244 375792 17636 55898395
Onychomycosis 49.71 10.59 125 375911 6447 55909584
Ill-defined disorder 49.69 10.59 687 375349 67856 55848175
Acute respiratory distress syndrome 49.57 10.59 44 375992 21882 55894149
Malocclusion 49.44 10.59 20 376016 76 55915955
Agranulocytosis 49.41 10.59 47 375989 22612 55893419
Mycotic allergy 48.77 10.59 42 375994 784 55915247
Emphysema 48.55 10.59 162 375874 9814 55906217
Mastication disorder 48.29 10.59 62 375974 1867 55914164
Scleritis 48.28 10.59 88 375948 3623 55912408
Plantar fasciitis 48.18 10.59 83 375953 3267 55912764
Orthostatic hypotension 47.97 10.59 93 375943 33106 55882925
Facet joint syndrome 47.95 10.59 125 375911 6592 55909439
Injection site urticaria 47.93 10.59 13 376023 12770 55903261
Dystonia 47.78 10.59 12 376024 12409 55903622
Osteomalacia 47.77 10.59 39 375997 674 55915357
Varicose vein operation 47.63 10.59 14 376022 12 55916019
Bunion operation 47.56 10.59 49 375987 1156 55914875
Accidental overdose 47.54 10.59 40 375996 20421 55895610
Multiple sclerosis 47.44 10.59 70 375966 27732 55888299
Oral fibroma 47.39 10.59 17 376019 42 55915989
Scapula fracture 47.34 10.59 32 376004 408 55915623
Lethargy 47.28 10.59 180 375856 51261 55864770
Dental prosthesis placement 47.20 10.59 18 376018 56 55915975
Purulence 47.16 10.59 53 375983 1384 55914647
Brain oedema 47.01 10.59 15 376021 13256 55902775
Upper limb fracture 46.96 10.59 233 375803 16922 55899109
Throat irritation 46.84 10.59 92 375944 32591 55883440
Tenosynovitis 46.80 10.59 186 375850 12275 55903756
Urinary bladder suspension 46.77 10.59 33 376003 453 55915578
Meniscus removal 46.44 10.59 15 376021 23 55916008
Gamma-glutamyltransferase increased 46.43 10.59 85 375951 30920 55885111
Hypothermia 46.16 10.59 13 376023 12457 55903574
Palpitations 46.15 10.59 434 375602 99238 55816793
Exposure during pregnancy 46.13 10.59 637 375399 135705 55780326
Akathisia 45.93 10.59 3 376033 8649 55907382
Rash macular 45.80 10.59 42 375994 20562 55895469
Injection site warmth 45.54 10.59 19 376017 14224 55901807
Osteogenesis imperfecta 45.32 10.59 29 376007 335 55915696
Comminuted fracture 45.27 10.59 34 376002 517 55915514
Cholecystectomy 45.14 10.59 155 375881 9529 55906502
Red blood cell sedimentation rate 44.87 10.59 93 375943 4215 55911816
Adenoidal disorder 44.85 10.59 21 376015 122 55915909
Sjogren's syndrome 44.74 10.59 44 375992 980 55915051
Device dislocation 44.66 10.59 51 375985 22555 55893476
Tendon disorder 44.32 10.59 107 375929 5378 55910653
Haematochezia 44.16 10.59 147 375889 43571 55872460
Respiratory disorder 44.14 10.59 101 375935 33856 55882175
Nightmare 44.12 10.59 29 376007 16797 55899234
Therapeutic response unexpected 43.85 10.59 30 376006 17014 55899017
Stevens-Johnson syndrome 43.84 10.59 52 375984 22611 55893420
Gingival pain 43.69 10.59 117 375919 6271 55909760
Lumbar vertebral fracture 43.55 10.59 100 375936 4864 55911167
Blood glucose decreased 43.51 10.59 38 375998 19049 55896982
Hypophagia 43.39 10.59 79 375957 28797 55887234
Bladder repair 43.37 10.59 19 376017 92 55915939
Product storage error 43.27 10.59 17 376019 13196 55902835
Liver function test increased 43.14 10.59 76 375960 28057 55887974
Cardiogenic shock 42.99 10.59 28 376008 16297 55899734
Hemiparesis 42.98 10.59 48 375988 21442 55894589
Product prescribing error 42.95 10.59 55 375981 23131 55892900
Spinal fusion surgery 42.72 10.59 93 375943 4363 55911668
Postmenopausal haemorrhage 42.66 10.59 60 375976 1976 55914055
Neuroleptic malignant syndrome 42.42 10.59 12 376024 11466 55904565
Oophorectomy 42.26 10.59 32 376004 493 55915538
Incisional drainage 42.24 10.59 29 376007 380 55915651
Gestational diabetes 42.21 10.59 3 376033 8061 55907970
Barrett's oesophagus 41.96 10.59 34 376002 581 55915450
Dermal cyst 41.96 10.59 52 375984 1510 55914521
Hypoxia 41.91 10.59 201 375835 53696 55862335
Phlebolith 41.75 10.59 21 376015 146 55915885
External fixation of fracture 41.54 10.59 11 376025 3 55916028
Colitis ulcerative 41.04 10.59 62 375974 24329 55891702
Circulatory collapse 41.03 10.59 47 375989 20756 55895275
Acute myeloid leukaemia 40.91 10.59 32 376004 16940 55899091
Salpingo-oophorectomy bilateral 40.88 10.59 20 376016 130 55915901
Spondylolysis 40.77 10.59 16 376020 55 55915976
Throat tightness 40.64 10.59 54 375982 22353 55893678
Bladder disorder 40.57 10.59 132 375904 7892 55908139
Cytopenia 40.39 10.59 8 376028 9747 55906284
Toxic skin eruption 40.30 10.59 14 376022 11725 55904306
Osteomyelitis acute 40.22 10.59 23 376013 213 55915818
Enthesopathy 40.19 10.59 132 375904 7931 55908100
Hormone therapy 40.15 10.59 10 376026 0 55916031
Stomatitis 40.06 10.59 1074 374962 119736 55796295
Carpal tunnel decompression 39.94 10.59 37 375999 763 55915268
Abortion induced 39.75 10.59 8 376028 9637 55906394
Thyroid neoplasm 39.65 10.59 82 375954 3711 55912320
Back disorder 39.64 10.59 153 375883 9960 55906071
Hallucination 39.57 10.59 181 375855 48968 55867063
Impaired fasting glucose 39.38 10.59 22 376014 194 55915837
Lower respiratory tract infection 39.36 10.59 1025 375011 113769 55802262
Hepatic cytolysis 39.22 10.59 12 376024 10894 55905137
Dental prosthesis user 39.02 10.59 15 376021 48 55915983
Hair follicle tumour benign 38.93 10.59 27 376009 360 55915671
Dermal sinus 38.76 10.59 13 376023 24 55916007
Anuria 38.73 10.59 15 376021 11745 55904286
Tongue disorder 38.66 10.59 151 375885 9885 55906146
Syncope 38.60 10.59 500 375536 107699 55808332
Ovarian disorder 38.43 10.59 34 376002 659 55915372
Device difficult to use 38.41 10.59 12 376024 10749 55905282
Radiotherapy 38.41 10.59 25 376011 298 55915733
Injection site rash 38.37 10.59 34 376002 16924 55899107
Traumatic ulcer 38.36 10.59 14 376022 37 55915994
Fibromyalgia 38.29 10.59 585 375451 59018 55857013
Therapeutic response shortened 38.23 10.59 8 376028 9378 55906653
Body temperature increased 38.23 10.59 110 375926 34132 55881899
Musculoskeletal stiffness 38.12 10.59 1336 374700 154671 55761360
Taste disorder 38.12 10.59 9 376027 9706 55906325
Oesophageal disorder 38.11 10.59 59 375977 2121 55913910
Intermittent claudication 38.10 10.59 53 375983 1727 55914304
Goitre 38.04 10.59 102 375934 5471 55910560
Post procedural fever 37.98 10.59 25 376011 304 55915727
Benign neoplasm of skin 37.91 10.59 19 376017 131 55915900
Eosinophilia 37.84 10.59 47 375989 20030 55896001
Mood altered 37.84 10.59 21 376015 13334 55902697
Labelled drug-drug interaction medication error 37.79 10.59 15 376021 11571 55904460
Oesophageal stenosis 37.71 10.59 70 375966 2923 55913108
Uterine prolapse 37.60 10.59 43 375993 1145 55914886
Torsade de pointes 37.57 10.59 18 376018 12422 55903609
Breast cyst 37.27 10.59 51 375985 1636 55914395
Acne 37.26 10.59 52 375984 21084 55894947
Groin pain 37.18 10.59 142 375894 9198 55906833
Metastases to liver 37.17 10.59 54 375982 21532 55894499
Bone fistula 37.08 10.59 15 376021 57 55915974
Frequent bowel movements 37.08 10.59 33 376003 16391 55899640
Arteriosclerosis 37.04 10.59 143 375893 9310 55906721
Drug hypersensitivity 36.98 10.59 1483 374553 273722 55642309
Post procedural constipation 36.77 10.59 16 376020 76 55915955
Affect lability 36.66 10.59 11 376025 10114 55905917
Haematotoxicity 36.60 10.59 6 376030 8377 55907654
Hepatic encephalopathy 36.58 10.59 11 376025 10099 55905932
Cerebral small vessel ischaemic disease 36.50 10.59 35 376001 755 55915276
Thrombotic microangiopathy 36.38 10.59 9 376027 9402 55906629
Sinus disorder 36.16 10.59 250 375786 20484 55895547
Tumour lysis syndrome 36.13 10.59 5 376031 7918 55908113
Respiratory depression 36.04 10.59 19 376017 12416 55903615
Metastases to central nervous system 35.99 10.59 18 376018 12118 55903913
Normal newborn 35.81 10.59 4 376032 7466 55908565
Ejection fraction decreased 35.80 10.59 48 375988 19793 55896238
Device malfunction 35.74 10.59 33 376003 16103 55899928
Skin laceration 35.73 10.59 244 375792 19912 55896119
Transplant rejection 35.60 10.59 11 376025 9923 55906108
Hyperbilirubinaemia 35.49 10.59 12 376024 10223 55905808
Reversible airways obstruction 35.46 10.59 45 375991 1339 55914692
Knee deformity 35.43 10.59 40 375996 1050 55914981
Second primary malignancy 35.39 10.59 4 376032 7398 55908633
Ilium fracture 35.34 10.59 18 376018 129 55915902
Metastases to lung 35.32 10.59 17 376019 11701 55904330
Dyspnoea exertional 35.32 10.59 217 375819 54472 55861559
Impaired quality of life 34.98 10.59 7 376029 8467 55907564
Laboratory test abnormal 34.97 10.59 70 375966 24625 55891406
Periostitis 34.79 10.59 23 376013 282 55915749
Myocardial infarction 34.68 10.59 425 375611 92445 55823586
Right ventricular failure 34.53 10.59 35 376001 16344 55899687
Epicondylitis 34.52 10.59 54 375982 1959 55914072
Gingival abscess 34.52 10.59 33 376003 709 55915322
Tardive dyskinesia 34.51 10.59 6 376030 8025 55908006
Joint injury 34.47 10.59 291 375745 25363 55890668
Ischaemic stroke 34.37 10.59 37 375999 16805 55899226
Depression 34.26 10.59 1501 374535 178616 55737415
Chondrocalcinosis 34.18 10.59 30 376006 575 55915456
Drug-induced liver injury 34.04 10.59 117 375919 34345 55881686
Eye pruritus 33.97 10.59 27 376009 14179 55901852
Cervicobrachial syndrome 33.92 10.59 35 376001 827 55915204
Periarthritis 33.81 10.59 55 375981 2064 55913967
Tachypnoea 33.65 10.59 32 376004 15398 55900633
Haemophagocytic lymphohistiocytosis 33.59 10.59 11 376025 9561 55906470
Senile osteoporosis 33.52 10.59 20 376016 202 55915829
Renal injury 33.39 10.59 9 376027 8878 55907153
Mental impairment 33.26 10.59 22 376014 12700 55903331
Skin cancer 32.99 10.59 147 375889 10208 55905823
Lymphopenia 32.97 10.59 38 375998 16736 55899295
Stress 32.93 10.59 244 375792 58666 55857365
Face oedema 32.93 10.59 45 375991 18407 55897624
Muscle rigidity 32.91 10.59 15 376021 10656 55905375
Neurectomy 32.86 10.59 9 376027 4 55916027
Osteitis deformans 32.78 10.59 20 376016 211 55915820
Oliguria 32.76 10.59 8 376028 8432 55907599
International normalised ratio increased 32.65 10.59 167 375869 43874 55872157
Atelectasis 32.61 10.59 231 375805 19077 55896954
Intestinal obstruction 32.60 10.59 88 375948 27883 55888148
Anxiety disorder 32.46 10.59 76 375960 3744 55912287
Melanocytic naevus 32.46 10.59 79 375957 3991 55912040
Tooth impacted 32.46 10.59 17 376019 130 55915901
Traumatic fracture 32.40 10.59 29 376007 571 55915460
Productive cough 32.35 10.59 231 375805 56001 55860030
Bone formation increased 32.19 10.59 18 376018 159 55915872
Petechiae 32.17 10.59 24 376012 13015 55903016
Amenorrhoea 32.11 10.59 10 376026 8976 55907055
Morton's neuralgia 32.09 10.59 14 376022 67 55915964
Genital haemorrhage 32.09 10.59 4 376032 6858 55909173
Infusion site erythema 32.05 10.59 12 376024 9594 55906437
Hyperthermia 31.87 10.59 8 376028 8277 55907754
Blood creatine phosphokinase increased 31.79 10.59 89 375947 27863 55888168
Aplastic anaemia 31.79 10.59 10 376026 8918 55907113
Pancreatitis acute 31.63 10.59 76 375960 25048 55890983
Vital capacity decreased 31.62 10.59 41 375995 1247 55914784
Vitamin B12 deficiency 31.61 10.59 82 375954 4311 55911720
Radicular pain 31.61 10.59 25 376011 412 55915619
Neuroma 31.57 10.59 24 376012 372 55915659
Adjustment disorder with depressed mood 31.47 10.59 90 375946 5013 55911018
Acrochordon 31.41 10.59 35 376001 905 55915126
Myocarditis 31.40 10.59 10 376026 8848 55907183
Blood pressure abnormal 31.38 10.59 27 376009 13633 55902398
Mammogram abnormal 31.29 10.59 30 376006 647 55915384
Hypercalciuria 31.25 10.59 21 376015 265 55915766
Iron deficiency anaemia 31.22 10.59 216 375820 17703 55898328
Tooth infection 31.15 10.59 196 375840 15556 55900475
Head discomfort 31.11 10.59 21 376015 11993 55904038
Hypersomnia 31.07 10.59 38 375998 16303 55899728
Dental alveolar anomaly 31.06 10.59 13 376023 55 55915976
Coma 31.04 10.59 252 375784 59403 55856628
Chondromalacia 30.86 10.59 21 376015 271 55915760
Blood lactate dehydrogenase increased 30.67 10.59 57 375979 20618 55895413
Haemoptysis 30.63 10.59 84 375952 26476 55889555
Retinitis 30.55 10.59 79 375957 4145 55911886
Metastases to bone 30.55 10.59 52 375984 19456 55896575
Swelling face 30.50 10.59 234 375802 55835 55860196
Breast cancer metastatic 30.45 10.59 35 376001 15434 55900597
Cyst 30.45 10.59 167 375869 12611 55903420
Skin burning sensation 30.32 10.59 18 376018 11013 55905018
Gastrointestinal toxicity 30.27 10.59 3 376033 6153 55909878
Skin fissures 30.24 10.59 13 376023 9560 55906471
Pulmonary fibrosis 30.21 10.59 318 375718 29440 55886591
Skin abrasion 30.10 10.59 125 375911 8416 55907615
Acute respiratory failure 30.09 10.59 106 375930 30888 55885143
Pulmonary congestion 30.09 10.59 38 375998 16077 55899954
Dislocation of vertebra 30.06 10.59 92 375944 5323 55910708
Urinary tract discomfort 30.05 10.59 22 376014 321 55915710
Hallucination, auditory 30.03 10.59 20 376016 11504 55904527
Haemorrhoid operation 30.00 10.59 22 376014 322 55915709
Rhinoplasty 29.96 10.59 9 376027 9 55916022
Leukoplakia 29.95 10.59 14 376022 81 55915950
Left ventricular hypertrophy 29.87 10.59 87 375949 4897 55911134
Hyperparathyroidism primary 29.83 10.59 22 376014 325 55915706
Trigger finger 29.70 10.59 75 375961 3878 55912153
Injection site haemorrhage 29.70 10.59 65 375971 22136 55893895
Stasis dermatitis 29.67 10.59 29 376007 641 55915390
Gingivectomy 29.60 10.59 8 376028 3 55916028
Cervical spinal stenosis 29.50 10.59 50 375986 1942 55914089
Post laminectomy syndrome 29.39 10.59 20 376016 258 55915773
Cerebrovascular accident 29.36 10.59 476 375560 98794 55817237
Mental disorder 29.25 10.59 72 375964 23532 55892499
Synovial fluid analysis 29.17 10.59 49 375987 1889 55914142
Bacteraemia 29.04 10.59 37 375999 15594 55900437
Avulsion fracture 28.94 10.59 20 376016 265 55915766
Jaw fistula 28.81 10.59 12 376024 50 55915981
Photosensitivity reaction 28.71 10.59 29 376007 13564 55902467
Product dispensing error 28.60 10.59 13 376023 9251 55906780
Hyponatraemia 28.50 10.59 495 375541 101644 55814387
Haemodynamic instability 28.48 10.59 10 376026 8319 55907712
Hypertensive crisis 28.46 10.59 31 376005 14005 55902026
Granuloma 28.41 10.59 91 375945 5396 55910635
Generalised oedema 28.34 10.59 33 376003 14468 55901563
Bradyphrenia 28.33 10.59 5 376031 6615 55909416
Blood pressure fluctuation 28.28 10.59 156 375880 40204 55875827
White blood cell count increased 28.18 10.59 179 375857 44580 55871451
Miosis 28.16 10.59 5 376031 6587 55909444
Dysstasia 28.15 10.59 54 375982 19300 55896731
Benign breast lump removal 28.11 10.59 7 376029 0 55916031
Device occlusion 28.02 10.59 5 376031 6564 55909467
Vertebroplasty 27.98 10.59 21 376015 319 55915712
Mental status changes 27.92 10.59 142 375894 37359 55878672
Dialysis 27.86 10.59 15 376021 9687 55906344
Therapeutic response decreased 27.85 10.59 222 375814 52536 55863495
Vaginal disorder 27.71 10.59 29 376007 697 55915334
Urethral caruncle 27.70 10.59 13 376023 76 55915955
Muscle twitching 27.61 10.59 41 375995 16201 55899830
Glomerular filtration rate decreased 27.56 10.59 25 376011 12304 55903727
Hereditary angioedema 27.48 10.59 6 376030 6829 55909202
Red cell distribution width increased 27.47 10.59 14 376022 9326 55906705
Kidney infection 27.46 10.59 61 375975 20664 55895367
Enterocele 27.41 10.59 12 376024 58 55915973
Inflammatory marker increased 27.41 10.59 4 376032 6086 55909945
Immunodeficiency 27.25 10.59 41 375995 16116 55899915
Complication of device insertion 27.17 10.59 5 376031 6419 55909612
Drug tolerance 27.12 10.59 95 375941 5899 55910132
Increased tendency to bruise 26.90 10.59 133 375903 9645 55906386
Pre-existing condition improved 26.85 10.59 8 376028 7390 55908641
Blood potassium decreased 26.81 10.59 150 375886 38522 55877509
Injection site induration 26.74 10.59 12 376024 8603 55907428
Poor dental condition 26.72 10.59 22 376014 385 55915646
Injury 26.54 10.59 554 375482 59297 55856734
Incorrect route of product administration 26.48 10.59 65 375971 21264 55894767
Glucose tolerance impaired 26.44 10.59 89 375947 5416 55910615
Neuritis 26.37 10.59 31 376005 851 55915180
Sputum culture positive 26.22 10.59 44 375992 1695 55914336
Neutrophil count increased 26.20 10.59 37 375999 14928 55901103
Mania 26.18 10.59 23 376013 11497 55904534
Joint dislocation reduction 26.15 10.59 8 376028 9 55916022
Progressive multifocal leukoencephalopathy 26.10 10.59 25 376011 11988 55904043
Uterine dilation and curettage 26.08 10.59 31 376005 861 55915170
Oesophageal discomfort 26.05 10.59 16 376020 171 55915860
Haematocrit decreased 25.99 10.59 142 375894 36687 55879344
Blood 25-hydroxycholecalciferol decreased 25.87 10.59 12 376024 68 55915963
Rhinitis perennial 25.74 10.59 9 376027 20 55916011
Lip neoplasm 25.70 10.59 8 376028 10 55916021
Skin haemorrhage 25.67 10.59 12 376024 8401 55907630
Hemiplegia 25.63 10.59 12 376024 8392 55907639
Emotional distress 25.54 10.59 107 375929 29656 55886375
Limb injury 25.51 10.59 244 375792 22026 55894005
Hyperaesthesia 25.43 10.59 13 376023 8644 55907387
Hot flush 25.42 10.59 195 375841 46531 55869500
Extrapyramidal disorder 25.37 10.59 27 376009 12329 55903702
Renal tubular necrosis 25.36 10.59 21 376015 10807 55905224
Vertigo positional 25.35 10.59 55 375981 2574 55913457
Lipoma 25.27 10.59 50 375986 2191 55913840
Condition aggravated 25.14 10.59 1973 374063 342925 55573106
Localised infection 25.13 10.59 96 375940 27316 55888715
Eye swelling 25.10 10.59 67 375969 21309 55894722
Haemodialysis 25.09 10.59 13 376023 8578 55907453
Cardiac failure acute 25.07 10.59 14 376022 8859 55907172
Mixed incontinence 25.05 10.59 12 376024 74 55915957
Gingival swelling 25.04 10.59 71 375965 3935 55912096
Grief reaction 24.94 10.59 17 376019 220 55915811
Raynaud's phenomenon 24.85 10.59 35 376001 1154 55914877
Delusion 24.76 10.59 23 376013 11192 55904839
Ventricular fibrillation 24.73 10.59 22 376014 10930 55905101
Oesophageal perforation 24.62 10.59 20 376016 343 55915688
Speech disorder 24.61 10.59 148 375888 37345 55878686
Infusion site extravasation 24.61 10.59 12 376024 8198 55907833
Myofascial pain syndrome 24.55 10.59 48 375988 2085 55913946
Anger 24.54 10.59 25 376011 11647 55904384
Urine calcium increased 24.51 10.59 11 376025 57 55915974
Needle issue 24.39 10.59 14 376022 8724 55907307
Cataract nuclear 24.34 10.59 30 376006 866 55915165
Psychomotor hyperactivity 24.32 10.59 18 376018 9802 55906229
Bone scan abnormal 24.24 10.59 20 376016 351 55915680
Bedridden 24.22 10.59 20 376016 10305 55905726
Pharyngeal oedema 24.11 10.59 32 376004 13253 55902778
Traumatic occlusion 24.09 10.59 6 376030 0 55916031
Tendon sheath lesion excision 24.09 10.59 6 376030 0 55916031
Radiotherapy to breast 24.09 10.59 6 376030 0 55916031
Pharyngitis streptococcal 24.06 10.59 17 376019 9481 55906550
Forearm fracture 24.05 10.59 22 376014 446 55915585
Glaucoma 24.05 10.59 198 375838 17131 55898900
Dupuytren's contracture 24.03 10.59 12 376024 82 55915949
Multiple fractures 23.99 10.59 105 375931 7236 55908795
Electrolyte imbalance 23.95 10.59 53 375983 17980 55898051
Mitral valve incompetence 23.91 10.59 205 375831 17948 55898083
Adenoidectomy 23.82 10.59 13 376023 109 55915922
Dental pulp disorder 23.81 10.59 7 376029 6 55916025
Fracture reduction 23.81 10.59 7 376029 6 55916025
Therapy change 23.80 10.59 4 376032 5484 55910547
Infection 23.80 10.59 1597 374439 198609 55717422
Maternal drugs affecting foetus 23.74 10.59 3 376033 5090 55910941
Liver function test abnormal 23.73 10.59 193 375843 45478 55870553
Rotator cuff repair 23.56 10.59 44 375992 1846 55914185
Graft versus host disease 23.43 10.59 8 376028 6773 55909258
Cervical polyp 23.41 10.59 16 376020 208 55915823
Breast mass 23.40 10.59 101 375935 6918 55909113
Sickle cell anaemia with crisis 23.34 10.59 3 376033 5025 55911006
Feeding disorder 23.34 10.59 27 376009 11873 55904158
End stage renal disease 23.32 10.59 6 376030 6105 55909926
Sialoadenitis 23.30 10.59 39 375997 1499 55914532
Blood calcium decreased 23.27 10.59 81 375955 23688 55892343
Incision site haematoma 23.20 10.59 11 376025 66 55915965
Rectal polyp 23.16 10.59 33 376003 1100 55914931
Joint arthroplasty 23.12 10.59 53 375983 2575 55913456
Clavicle fracture 23.12 10.59 58 375978 2987 55913044
Infusion site swelling 23.11 10.59 12 376024 7909 55908122
Enchondromatosis 23.07 10.59 11 376025 67 55915964
Injection site extravasation 23.00 10.59 13 376023 8171 55907860
Cerebrovascular disorder 23.00 10.59 53 375983 2584 55913447
Infective pulmonary exacerbation of cystic fibrosis 22.86 10.59 13 376023 8144 55907887
Palatal disorder 22.83 10.59 17 376019 255 55915776
Leukoplakia oral 22.69 10.59 14 376022 151 55915880
Pathogen resistance 22.69 10.59 6 376030 5994 55910037
Paranoia 22.60 10.59 23 376013 10721 55905310
Intestinal perforation 22.45 10.59 24 376012 10935 55905096
Sinus tarsi syndrome 22.38 10.59 7 376029 9 55916022
Anti-cyclic citrullinated peptide antibody 22.32 10.59 65 375971 3658 55912373
Jaundice 22.27 10.59 100 375936 27194 55888837
Cyanosis 22.23 10.59 45 375991 15765 55900266
Face injury 22.21 10.59 56 375980 2893 55913138
Dermatitis atopic 22.17 10.59 14 376022 8285 55907746
Pneumonia viral 22.17 10.59 10 376026 7148 55908883
Fibroadenoma of breast 22.17 10.59 20 376016 398 55915633
Presbyopia 22.16 10.59 21 376015 446 55915585
Nervous system disorder 22.14 10.59 50 375986 16839 55899192
SARS-CoV-2 test positive 22.14 10.59 7 376029 6222 55909809
Hypomagnesaemia 22.04 10.59 89 375947 24926 55891105
Osteosclerosis 22.01 10.59 64 375972 3599 55912432
Malpositioned teeth 21.96 10.59 8 376028 21 55916010
Incorrect product administration duration 21.84 10.59 22 376014 10304 55905727
Benign bone neoplasm 21.70 10.59 9 376027 37 55915994
Cataract cortical 21.70 10.59 9 376027 37 55915994
Osteorrhagia 21.68 10.59 6 376030 3 55916028
Drug level decreased 21.67 10.59 10 376026 7054 55908977
Hypokalaemia 21.67 10.59 473 375563 93964 55822067
Increased appetite 21.65 10.59 16 376020 8719 55907312
Candida infection 21.57 10.59 93 375943 25574 55890457
Incision site cellulitis 21.48 10.59 13 376023 135 55915896
Intentional dose omission 21.48 10.59 7 376029 6103 55909928
Cerebral haemorrhage 21.47 10.59 108 375928 28498 55887533
Blood alkaline phosphatase increased 21.43 10.59 162 375874 38783 55877248
Menopausal symptoms 21.40 10.59 46 375990 2139 55913892
Denture wearer 21.38 10.59 15 376021 204 55915827
Hypocalcaemia 21.35 10.59 109 375927 28651 55887380
Motor dysfunction 21.35 10.59 19 376017 9438 55906593
Otitis externa 21.34 10.59 39 375997 1609 55914422
Dystrophic calcification 21.27 10.59 12 376024 108 55915923
Retching 21.25 10.59 36 376000 13494 55902537
Central nervous system lesion 21.22 10.59 21 376015 9917 55906114
Splenic granuloma 21.20 10.59 7 376029 12 55916019
Laryngeal ulceration 21.20 10.59 7 376029 12 55916019
Odontogenic cyst 21.19 10.59 8 376028 24 55916007
Glycosylated haemoglobin increased 21.19 10.59 26 376010 11139 55904892
Persistent depressive disorder 21.19 10.59 28 376008 868 55915163
Dementia Alzheimer's type 21.17 10.59 31 376005 1060 55914971
Hypertensive heart disease 21.17 10.59 48 375988 2315 55913716
Muscle spasms 21.16 10.59 728 375308 136643 55779388
Bone atrophy 21.10 10.59 10 376026 60 55915971
Benign neoplasm 21.09 10.59 28 376008 872 55915159
Live birth 21.09 10.59 212 375824 19393 55896638
Atrial fibrillation 20.99 10.59 560 375476 108337 55807694
Spinal claudication 20.96 10.59 10 376026 61 55915970
Vulvovaginal dryness 20.90 10.59 49 375987 2416 55913615
Immune reconstitution inflammatory syndrome 20.85 10.59 6 376030 5668 55910363
Bone sarcoma 20.85 10.59 7 376029 13 55916018
Aspergillus infection 20.78 10.59 12 376024 7453 55908578
Prescribed overdose 20.67 10.59 234 375802 22062 55893969
Rash papular 20.66 10.59 36 376000 13347 55902684
Inguinal hernia repair 20.64 10.59 9 376027 43 55915988
Metatarsalgia 20.57 10.59 16 376020 257 55915774
Shock haemorrhagic 20.57 10.59 18 376018 9015 55907016
Peripheral coldness 20.52 10.59 26 376010 10985 55905046
Nasal disorder 20.47 10.59 50 375986 2532 55913499
Sneezing 20.45 10.59 46 375990 15514 55900517
Vascular device infection 20.37 10.59 6 376030 5584 55910447
Traumatic arthritis 20.28 10.59 8 376028 28 55916003
Swollen tongue 20.28 10.59 119 375917 30205 55885826
Bronchial secretion retention 20.25 10.59 41 375995 1827 55914204
Catheter site infection 20.23 10.59 3 376033 4511 55911520
Cold sweat 20.23 10.59 26 376010 10917 55905114
Cervical radiculopathy 20.16 10.59 27 376009 848 55915183
Tooth resorption 20.15 10.59 9 376027 46 55915985
White blood cell count abnormal 20.14 10.59 7 376029 5860 55910171
Apicectomy 20.08 10.59 5 376031 0 55916031
Fibrous dysplasia of bone 20.08 10.59 5 376031 0 55916031
Chondroplasty 20.08 10.59 5 376031 0 55916031
Gastrooesophageal cancer 20.08 10.59 5 376031 0 55916031
Haemolytic anaemia 20.07 10.59 21 376015 9664 55906367
Oesophageal injury 20.06 10.59 8 376028 29 55916002
Skin plaque 20.04 10.59 11 376025 7027 55909004
Balance disorder 20.03 10.59 375 375661 76145 55839886
Intervertebral disc space narrowing 20.02 10.59 28 376008 917 55915114
Poor venous access 20.02 10.59 32 376004 12274 55903757
Actinic elastosis 19.97 10.59 6 376030 6 55916025
Emotional disorder 19.97 10.59 32 376004 12263 55903768
Trigeminal neuralgia 19.96 10.59 59 375977 3348 55912683
Temperature regulation disorder 19.96 10.59 3 376033 4465 55911566
X-ray of pelvis and hip abnormal 19.89 10.59 7 376029 16 55916015
Hormone level abnormal 19.88 10.59 46 375990 2249 55913782
Uterine leiomyoma 19.86 10.59 109 375927 8233 55907798
Hepatic function abnormal 19.86 10.59 142 375894 34416 55881615
Blood creatinine decreased 19.85 10.59 5 376031 5161 55910870
Ventricular tachycardia 19.83 10.59 53 375983 16848 55899183
Wound drainage 19.75 10.59 25 376011 742 55915289
Electrocardiogram QRS complex prolonged 19.69 10.59 6 376030 5461 55910570
Suspected suicide 19.68 10.59 6 376030 5460 55910571
Oesophageal ulcer haemorrhage 19.64 10.59 18 376018 366 55915665
Hepatomegaly 19.62 10.59 28 376008 11247 55904784
Disseminated intravascular coagulation 19.57 10.59 58 375978 17827 55898204
Sensitivity to weather change 19.51 10.59 10 376026 6639 55909392
Klebsiella infection 19.49 10.59 14 376022 7742 55908289
Uterovaginal prolapse 19.48 10.59 10 376026 73 55915958
Inappropriate antidiuretic hormone secretion 19.47 10.59 39 375997 13717 55902314
Aortic stenosis 19.46 10.59 69 375967 4311 55911720
Hyperkeratosis 19.43 10.59 79 375957 5268 55910763
Parathyroidectomy 19.39 10.59 15 376021 239 55915792
Reflux laryngitis 19.32 10.59 12 376024 131 55915900
Atrioventricular block 19.27 10.59 11 376025 6876 55909155
Dermatitis acneiform 19.21 10.59 3 376033 4341 55911690
Apathy 19.16 10.59 15 376021 7939 55908092
Breath odour 19.12 10.59 32 376004 1230 55914801
Restless legs syndrome 19.07 10.59 185 375851 16762 55899269
Wrong product administered 19.07 10.59 7 376029 5665 55910366
Post transplant lymphoproliferative disorder 18.99 10.59 4 376032 4668 55911363
Tumour marker increased 18.91 10.59 3 376033 4290 55911741
Embolism 18.89 10.59 13 376023 7351 55908680
Bone infarction 18.88 10.59 16 376020 292 55915739
Hallucination, visual 18.86 10.59 57 375979 17411 55898620
Oophorectomy bilateral 18.85 10.59 9 376027 55 55915976
Animal scratch 18.80 10.59 29 376007 1039 55914992
Joint surgery 18.73 10.59 17 376019 341 55915690
Spondylitis 18.73 10.59 55 375981 3110 55912921
Expired product administered 18.69 10.59 7 376029 5595 55910436
Clonus 18.64 10.59 3 376033 4246 55911785
Pulmonary hypertension 18.62 10.59 152 375884 35792 55880239
Dermatitis bullous 18.61 10.59 14 376022 7559 55908472
Spinal decompression 18.58 10.59 14 376022 214 55915817
Intermenstrual bleeding 18.58 10.59 12 376024 7015 55909016
Hospice care 18.58 10.59 9 376027 6171 55909860
Hyperammonaemia 18.57 10.59 5 376031 4935 55911096
Stress cardiomyopathy 18.52 10.59 17 376019 8319 55907712
Proteinuria 18.49 10.59 58 375978 17512 55898519
Respiratory acidosis 18.49 10.59 9 376027 6154 55909877
Sight disability 18.44 10.59 11 376025 111 55915920
Thermohypoaesthesia 18.36 10.59 11 376025 112 55915919
Hypoparathyroidism 18.32 10.59 22 376014 618 55915413
Middle insomnia 18.26 10.59 28 376008 10922 55905109
Staphylococcal bacteraemia 18.25 10.59 6 376030 5203 55910828
Red blood cell sedimentation rate increased 18.25 10.59 345 375691 36278 55879753
Deep vein thrombosis postoperative 18.25 10.59 64 375972 3977 55912054
Inflammation 18.24 10.59 597 375439 68474 55847557
Menstruation irregular 18.21 10.59 10 376026 6386 55909645
Cholecystitis chronic 18.18 10.59 23 376013 9725 55906306
Gingival ulceration 18.17 10.59 25 376011 806 55915225
Full blood count abnormal 18.14 10.59 103 375933 26359 55889672
Labyrinthitis 18.13 10.59 44 375992 2219 55913812
Lacunar infarction 17.99 10.59 54 375982 3091 55912940
Ventricular septal defect 17.98 10.59 3 376033 4135 55911896
Labile hypertension 17.98 10.59 19 376017 462 55915569
Respiratory syncytial virus infection 17.93 10.59 7 376029 5454 55910577
Oral discharge 17.89 10.59 12 376024 151 55915880
Anhedonia 17.87 10.59 24 376012 9890 55906141
Haemolysis 17.86 10.59 10 376026 6318 55909713
Device extrusion 17.85 10.59 7 376029 24 55916007
Mouth cyst 17.82 10.59 10 376026 89 55915942
Intestinal adhesion lysis 17.75 10.59 5 376031 3 55916028
Insomnia 17.69 10.59 1075 374961 190785 55725246
Skin graft 17.59 10.59 20 376016 529 55915502
Oesophagitis chemical 17.58 10.59 6 376030 12 55916019
Facial bones fracture 17.58 10.59 56 375980 3311 55912720
Tendon sheath incision 17.50 10.59 9 376027 66 55915965
Carotid endarterectomy 17.42 10.59 11 376025 124 55915907
Vertebrobasilar insufficiency 17.38 10.59 9 376027 67 55915964
Encephalitis 17.38 10.59 17 376019 8073 55907958
Aortic valve incompetence 17.38 10.59 79 375957 5533 55910498
Atrial septal defect 17.35 10.59 11 376025 6495 55909536
Lenticular opacities 17.34 10.59 14 376022 238 55915793
Maternal exposure timing unspecified 17.29 10.59 77 375959 5346 55910685
Aortic aneurysm 17.19 10.59 56 375980 3350 55912681
Hepatic necrosis 17.15 10.59 7 376029 5309 55910722
Pneumocystis jirovecii pneumonia 17.12 10.59 51 375985 15650 55900381
Injection site discolouration 17.10 10.59 14 376022 7245 55908786
Benign breast neoplasm 17.08 10.59 29 376007 1128 55914903
Menstrual disorder 17.07 10.59 5 376031 4670 55911361
Foot operation 17.07 10.59 85 375951 6182 55909849
Bronchitis chronic 17.01 10.59 62 375974 3926 55912105
Loss of employment 16.97 10.59 39 375997 1898 55914133
Lipase increased 16.94 10.59 21 376015 8958 55907073
Bone cyst 16.87 10.59 41 375995 2069 55913962
Large intestine benign neoplasm 16.84 10.59 10 376026 100 55915931
Renal disorder 16.84 10.59 122 375914 29483 55886548
Bladder prolapse 16.78 10.59 39 375997 1912 55914119
Tongue geographic 16.74 10.59 9 376027 73 55915958
Nystagmus 16.74 10.59 9 376027 5816 55910215
Hyperglycaemia 16.73 10.59 169 375867 38112 55877919
Breast fibrosis 16.68 10.59 6 376030 15 55916016
Parathyroid disorder 16.67 10.59 20 376016 561 55915470
Osteocalcin decreased 16.61 10.59 8 376028 50 55915981
Breast cancer female 16.60 10.59 36 376000 12302 55903729
Abdominal hernia 16.59 10.59 68 375968 4551 55911480
Purulent discharge 16.58 10.59 66 375970 4358 55911673
Arrhythmia 16.56 10.59 152 375884 34931 55881100
Foreign body 16.55 10.59 41 375995 2095 55913936
Neurosensory hypoacusis 16.45 10.59 13 376023 214 55915817
Oesophageal haemorrhage 16.44 10.59 19 376017 512 55915519
Paraesthesia oral 16.43 10.59 46 375990 14403 55901628
Parathyroid tumour benign 16.42 10.59 21 376015 630 55915401
Mastoid disorder 16.40 10.59 6 376030 16 55916015
Coma scale abnormal 16.35 10.59 6 376030 4857 55911174
Kidney transplant rejection 16.34 10.59 4 376032 4209 55911822
Meralgia paraesthetica 16.32 10.59 15 376021 306 55915725
Sacroiliitis 16.24 10.59 48 375988 2724 55913307
Spinal deformity 16.21 10.59 26 376010 964 55915067
Artificial crown procedure 16.14 10.59 14 376022 264 55915767
Pulmonary haemorrhage 16.08 10.59 13 376023 6770 55909261
Reaction to food additive 16.06 10.59 4 376032 0 55916031
Uterine cervix atrophy 16.06 10.59 4 376032 0 55916031
Lipoma of breast 16.06 10.59 4 376032 0 55916031
Arthrotomy 16.06 10.59 4 376032 0 55916031
Loss of anatomical alignment after fracture reduction 16.06 10.59 4 376032 0 55916031
Intervertebral disc annular tear 16.06 10.59 4 376032 0 55916031
Impacted fracture 16.06 10.59 4 376032 0 55916031
Metatarsus primus varus 16.06 10.59 4 376032 0 55916031
Pulmonary thrombosis 16.02 10.59 18 376018 8019 55908012
Incorrect dose administered by device 15.98 10.59 3 376033 3797 55912234
Alanine aminotransferase increased 15.93 10.59 490 375546 93172 55822859
Salivary gland mass 15.86 10.59 9 376027 82 55915949
Juvenile idiopathic arthritis 15.86 10.59 6 376030 4767 55911264
Drug dependence 15.83 10.59 87 375949 22446 55893585
Otitis media 15.83 10.59 68 375968 4648 55911383
Respiration abnormal 15.80 10.59 9 376027 5632 55910399
Thalassaemia beta 15.75 10.59 5 376031 7 55916024
Urinary bladder polyp 15.74 10.59 8 376028 57 55915974
Transplant dysfunction 15.72 10.59 6 376030 4740 55911291
Repetitive strain injury 15.71 10.59 11 376025 149 55915882
Pulmonary granuloma 15.68 10.59 30 376006 1282 55914749
Epstein-Barr virus infection 15.67 10.59 16 376020 7447 55908584
Vitreous degeneration 15.66 10.59 6 376030 19 55916012
Vaginal prolapse 15.65 10.59 17 376019 427 55915604
Peritonitis bacterial 15.65 10.59 6 376030 4727 55911304
Gouty arthritis 15.59 10.59 19 376017 542 55915489
Eustachian tube disorder 15.59 10.59 9 376027 85 55915946
Lip swelling 15.56 10.59 107 375929 26165 55889866
Ketoacidosis 15.55 10.59 4 376032 4071 55911960
Acidosis 15.53 10.59 29 376007 10472 55905559
Hunger 15.53 10.59 6 376030 4705 55911326
Pain of skin 15.51 10.59 21 376015 8625 55907406
Hypertransaminasaemia 15.51 10.59 6 376030 4701 55911330
Tooth discolouration 15.46 10.59 24 376012 865 55915166
Respiratory tract infection 15.46 10.59 160 375876 35911 55880120
Hypersensitivity vasculitis 15.40 10.59 4 376032 4044 55911987
Gastrointestinal infection 15.39 10.59 18 376018 7876 55908155
Blood pressure systolic abnormal 15.37 10.59 26 376010 9751 55906280
Infusion site haemorrhage 15.36 10.59 3 376033 3692 55912339
Left ventricular dysfunction 15.35 10.59 32 376004 11091 55904940
Dental discomfort 15.31 10.59 16 376020 384 55915647
Euphoric mood 15.30 10.59 5 376031 4353 55911678
Brain injury 15.29 10.59 12 376024 6343 55909688
Acute pulmonary oedema 15.16 10.59 17 376019 7580 55908451
Ammonia increased 15.14 10.59 5 376031 4324 55911707
Hip deformity 15.11 10.59 12 376024 199 55915832
Immobile 15.09 10.59 9 376027 5493 55910538
Blood test abnormal 15.06 10.59 40 375996 12744 55903287
Blood pressure diastolic decreased 15.05 10.59 72 375964 19251 55896780
Bone marrow oedema 15.01 10.59 26 376010 1028 55915003
Tympanosclerosis 14.99 10.59 5 376031 9 55916022
Benign gastric neoplasm 14.99 10.59 5 376031 9 55916022
Nail operation 14.96 10.59 22 376014 755 55915276
Catheter site pain 14.95 10.59 5 376031 4288 55911743
Catatonia 14.92 10.59 4 376032 3960 55912071
Acute generalised exanthematous pustulosis 14.83 10.59 27 376009 9842 55906189
Mixed liver injury 14.81 10.59 4 376032 3940 55912091
Feeling cold 14.78 10.59 82 375954 21105 55894926
Immune thrombocytopenia 14.76 10.59 26 376010 9599 55906432
Lymphadenopathy 14.75 10.59 157 375879 35051 55880980
Mastectomy 14.74 10.59 32 376004 1498 55914533
Neutrophilia 14.74 10.59 4 376032 3929 55912102
Breast cancer stage I 14.70 10.59 12 376024 6218 55909813
Cardiac failure congestive 14.65 10.59 460 375576 87260 55828771
Symphysiolysis 14.65 10.59 5 376031 10 55916021
Acute myocardial infarction 14.64 10.59 131 375905 30262 55885769
Vascular headache 14.63 10.59 7 376029 43 55915988
Pain in extremity 14.62 10.59 2232 373804 295199 55620832
Toxic encephalopathy 14.56 10.59 11 376025 5927 55910104
Galactorrhoea 14.53 10.59 4 376032 3891 55912140
Peripheral sensory neuropathy 14.51 10.59 15 376021 6941 55909090
Intestinal ischaemia 14.50 10.59 15 376021 6940 55909091
Product preparation error 14.50 10.59 7 376029 4809 55911222
Intervertebral disc displacement 14.47 10.59 16 376020 410 55915621
Hypoaesthesia 14.45 10.59 785 375251 140706 55775325
Bone trimming 14.41 10.59 6 376030 25 55916006
Electrocardiogram ST-T change 14.38 10.59 25 376011 991 55915040
Poliomyelitis 14.37 10.59 7 376029 45 55915986
Erosive oesophagitis 14.34 10.59 33 376003 1607 55914424
Injection site nodule 14.33 10.59 3 376033 3516 55912515
Rash pustular 14.32 10.59 14 376022 6649 55909382
Hepatitis acute 14.30 10.59 21 376015 8336 55907695
Ureterolithiasis 14.27 10.59 35 376001 1777 55914254
Scab 14.25 10.59 15 376021 6883 55909148
Pelvic floor muscle weakness 14.24 10.59 7 376029 46 55915985
Tubulointerstitial nephritis 14.24 10.59 60 375976 16605 55899426
Hypergammaglobulinaemia benign monoclonal 14.23 10.59 21 376015 723 55915308
Poor personal hygiene 14.23 10.59 14 376022 312 55915719
Blood potassium increased 14.23 10.59 63 375973 17198 55898833
Neoplasm skin 14.22 10.59 27 376009 1147 55914884
Tooth dislocation 14.22 10.59 6 376030 26 55916005
Major depression 14.16 10.59 93 375943 7491 55908540
Musculoskeletal discomfort 14.12 10.59 169 375867 16149 55899882
Blood magnesium decreased 14.11 10.59 37 375999 11837 55904194
Breast hyperplasia 14.08 10.59 13 376023 267 55915764
Bursa disorder 14.08 10.59 11 376025 178 55915853
Dermatitis exfoliative 14.07 10.59 9 376027 5290 55910741
Cushingoid 14.06 10.59 91 375945 7293 55908738
Peritonitis 14.05 10.59 58 375978 16144 55899887
Retinal operation 14.04 10.59 6 376030 27 55916004
Presbyoesophagus 14.04 10.59 5 376031 12 55916019
Hypereosinophilic syndrome 14.04 10.59 13 376023 268 55915763
Chronic sinusitis 14.01 10.59 100 375936 8278 55907753
Personality change 13.98 10.59 11 376025 5806 55910225
Viral infection 13.98 10.59 141 375895 31805 55884226
Ventricular arrhythmia 13.95 10.59 3 376033 3451 55912580
Lupus vulgaris 13.87 10.59 36 376000 1893 55914138
Chondrocalcinosis pyrophosphate 13.85 10.59 27 376009 1170 55914861
Pseudarthrosis 13.85 10.59 16 376020 431 55915600
Osteodystrophy 13.84 10.59 4 376032 3 55916028
Joint irrigation 13.84 10.59 4 376032 3 55916028
Sensory loss 13.82 10.59 24 376012 8911 55907120
Jaundice cholestatic 13.82 10.59 10 376026 5509 55910522
Insulin-requiring type 2 diabetes mellitus 13.82 10.59 8 376028 76 55915955
Colorectal cancer 13.81 10.59 3 376033 3426 55912605
Uterine polyp 13.81 10.59 35 376001 1814 55914217
Polyneuropathy 13.79 10.59 43 375993 13007 55903024
Ovarian cystectomy 13.77 10.59 10 376026 144 55915887
Dermatitis exfoliative generalised 13.76 10.59 3 376033 3417 55912614
Laryngitis 13.74 10.59 148 375888 13782 55902249
Upper-airway cough syndrome 13.72 10.59 109 375927 9329 55906702
Staphylococcal infection 13.72 10.59 173 375863 37445 55878586
Blood sodium decreased 13.71 10.59 90 375946 22244 55893787
Hypotonia 13.71 10.59 23 376013 8654 55907377
Abdominal pain lower 13.70 10.59 94 375942 22998 55893033
Elbow operation 13.69 10.59 13 376023 277 55915754
Tonsillitis 13.68 10.59 9 376027 5211 55910820
Pyogenic granuloma 13.65 10.59 13 376023 278 55915753
Blepharospasm 13.63 10.59 3 376033 3395 55912636
Eyelid oedema 13.56 10.59 28 376008 9740 55906291
Parathyroid gland operation 13.54 10.59 6 376030 30 55916001
Tunnel vision 13.53 10.59 22 376014 825 55915206
Hormone replacement therapy 13.50 10.59 5 376031 14 55916017
Lithotripsy 13.50 10.59 5 376031 14 55916017
Mammoplasty 13.42 10.59 17 376019 505 55915526
Immune system disorder 13.39 10.59 24 376012 8803 55907228
Anticoagulant therapy 13.38 10.59 6 376030 31 55916000
Procedural hypotension 13.32 10.59 26 376010 1128 55914903
Flatulence 13.32 10.59 139 375897 31149 55884882
Umbilical hernia repair 13.31 10.59 8 376028 82 55915949
Tongue oedema 13.30 10.59 5 376031 3987 55912044
Drug specific antibody present 13.28 10.59 4 376032 3668 55912363
Callus formation delayed 13.25 10.59 5 376031 15 55916016
Large intestinal polypectomy 13.24 10.59 11 376025 195 55915836
Oral pain 13.21 10.59 248 375788 26045 55889986
Chromaturia 13.21 10.59 55 375981 15270 55900761
Haemoglobin increased 13.18 10.59 3 376033 3317 55912714
Skin reaction 13.14 10.59 44 375992 13019 55903012
Hypovolaemic shock 13.11 10.59 10 376026 5363 55910668
Anaemia vitamin B12 deficiency 13.10 10.59 14 376022 345 55915686
Device leakage 13.01 10.59 14 376022 6361 55909670
Sebaceous hyperplasia 13.01 10.59 5 376031 16 55916015
Intentional product use issue 13.01 10.59 802 375234 98931 55817100
Substance abuse 12.99 10.59 7 376029 4518 55911513
Breast operation 12.98 10.59 15 376021 404 55915627
Vascular operation 12.91 10.59 9 376027 121 55915910
Heart rate abnormal 12.88 10.59 7 376029 4496 55911535
Ear disorder 12.86 10.59 52 375984 3459 55912572
Initial insomnia 12.85 10.59 11 376025 5568 55910463
Ataxia 12.84 10.59 51 375985 14352 55901679
Product substitution issue 12.83 10.59 52 375984 14547 55901484
Female genital tract fistula 12.82 10.59 7 376029 4485 55911546
Rash 12.81 10.59 3587 372449 489460 55426571
Anal abscess 12.79 10.59 6 376030 4191 55911840
Cystocele repair 12.78 10.59 5 376031 17 55916014
Drug dose omission by device 12.78 10.59 3 376033 3248 55912783
Supraventricular extrasystoles 12.76 10.59 58 375978 4062 55911969
Coagulopathy 12.75 10.59 73 375963 18643 55897388
Vascular insufficiency 12.74 10.59 12 376024 253 55915778
Piriformis syndrome 12.74 10.59 10 376026 163 55915868
Parkinsonism 12.72 10.59 28 376008 9518 55906513
Cerebral infarction 12.68 10.59 93 375943 22412 55893619
Coccydynia 12.67 10.59 28 376008 1327 55914704
X-ray abnormal 12.63 10.59 60 375976 4281 55911750
Jaw clicking 12.57 10.59 5 376031 18 55916013
Rectocele repair 12.57 10.59 5 376031 18 55916013
Device intolerance 12.50 10.59 7 376029 62 55915969
Meningitis 12.50 10.59 15 376021 6489 55909542
Paralysis 12.45 10.59 26 376010 9006 55907025
Blood urea increased 12.45 10.59 104 375932 24369 55891662
Pulse absent 12.44 10.59 9 376027 4958 55911073
Dysplastic naevus syndrome 12.44 10.59 4 376032 6 55916025
Panic reaction 12.42 10.59 5 376031 3825 55912206
Product dose omission in error 12.42 10.59 7 376029 4407 55911624
Cardiomyopathy 12.42 10.59 61 375975 16197 55899834
Visual impairment 12.42 10.59 389 375647 73813 55842218
Decreased immune responsiveness 12.37 10.59 7 376029 4396 55911635
Coordination abnormal 12.36 10.59 43 375993 12578 55903453
Incorrect drug administration rate 12.31 10.59 3 376033 3167 55912864
Hypoventilation 12.31 10.59 7 376029 4385 55911646
Urine abnormality 12.30 10.59 16 376020 6683 55909348
Vaginal dysplasia 12.26 10.59 6 376030 39 55915992
Skin infection 12.23 10.59 46 375990 13149 55902882
Migraine 12.22 10.59 465 375571 86332 55829699
Nephropathy toxic 12.22 10.59 24 376012 8503 55907528
Leukoencephalopathy 12.19 10.59 6 376030 4076 55911955
Abscess neck 12.17 10.59 18 376018 621 55915410
Vulva cyst 12.16 10.59 5 376031 20 55916011
Personality disorder 12.16 10.59 10 376026 5163 55910868
Haemorrhage intracranial 12.13 10.59 44 375992 12711 55903320
Alanine aminotransferase abnormal 12.09 10.59 59 375977 4256 55911775
Rosacea 12.07 10.59 57 375979 4056 55911975
Cubital tunnel syndrome 12.07 10.59 12 376024 271 55915760
Seronegative arthritis 12.07 10.59 43 375993 2693 55913338
Vascular skin disorder 12.06 10.59 4 376032 7 55916024
Myofascitis 12.06 10.59 4 376032 7 55916024
Modified radical mastectomy 12.06 10.59 4 376032 7 55916024
Staphylococcal sepsis 12.06 10.59 19 376017 7330 55908701
Articular disc disorder 12.05 10.59 3 376033 0 55916031
Benign neoplasm of spinal cord 12.05 10.59 3 376033 0 55916031
Alcohol detoxification 12.05 10.59 3 376033 0 55916031
Erythroplasia 12.05 10.59 3 376033 0 55916031
Femoral hernia repair 12.05 10.59 3 376033 0 55916031
Prolapse repair 12.05 10.59 3 376033 0 55916031
Epidural fibrosis 12.05 10.59 3 376033 0 55916031
Intestinal mucosal tear 12.05 10.59 3 376033 0 55916031
Traumatic arthropathy 12.05 10.59 3 376033 0 55916031
Deafness traumatic 12.05 10.59 3 376033 0 55916031
Mastoid abscess 12.05 10.59 3 376033 0 55916031
Spinal corpectomy 12.05 10.59 3 376033 0 55916031
Dental examination abnormal 12.05 10.59 3 376033 0 55916031
Fracture debridement 12.05 10.59 3 376033 0 55916031
Urosepsis 12.04 10.59 64 375972 16652 55899379
Neurogenic bowel 12.03 10.59 9 376027 136 55915895
Gastrointestinal tract adenoma 12.02 10.59 13 376023 325 55915706
Cystitis 12.01 10.59 243 375793 48795 55867236
Walking aid user 12 10.59 97 375939 8346 55907685
Weight increased 11.99 10.59 1347 374689 228356 55687675
Hyperventilation 11.98 10.59 12 376024 5636 55910395
Leriche syndrome 11.97 10.59 5 376031 21 55916010
Acute coronary syndrome 11.94 10.59 30 376006 9738 55906293
Spider vein 11.93 10.59 12 376024 275 55915756
Dacryostenosis acquired 11.91 10.59 16 376020 504 55915527
Cytomegalovirus viraemia 11.91 10.59 10 376026 5110 55910921
Blepharitis 11.90 10.59 39 375997 2341 55913690
Bradykinesia 11.89 10.59 9 376027 4845 55911186
Psychiatric symptom 11.84 10.59 9 376027 4835 55911196
Costochondritis 11.81 10.59 39 375997 2350 55913681
Lip dry 11.80 10.59 108 375928 9632 55906399
Pericoronitis 11.79 10.59 5 376031 22 55916009
Arthrofibrosis 11.79 10.59 5 376031 22 55916009
Respiratory rate increased 11.78 10.59 42 375994 12195 55903836
Ankylosing spondylitis 11.75 10.59 31 376005 9899 55906132
Skin mass 11.75 10.59 11 376025 5333 55910698
Granulocytopenia 11.75 10.59 11 376025 5333 55910698
Gastric ulcer 11.74 10.59 214 375822 22349 55893682
Osteochondroma 11.72 10.59 4 376032 8 55916023
Breast necrosis 11.71 10.59 9 376027 142 55915889
Upper respiratory tract infection 11.62 10.59 375 375661 70913 55845118
Breast cyst excision 11.62 10.59 7 376029 72 55915959
Disturbance in social behaviour 11.58 10.59 3 376033 3038 55912993
Laryngeal neoplasm 11.55 10.59 6 376030 45 55915986
Allergy to vaccine 11.51 10.59 10 376026 189 55915842
Internal haemorrhage 11.46 10.59 9 376027 4755 55911276
Wound dehiscence 11.46 10.59 61 375975 4554 55911477
Renal cancer 11.45 10.59 11 376025 5268 55910763
Demyelination 11.45 10.59 15 376021 6247 55909784
Lip neoplasm malignant stage unspecified 11.45 10.59 5 376031 24 55916007
Medical device pain 11.44 10.59 29 376007 1503 55914528
Sudden death 11.43 10.59 30 376006 9595 55906436
Heparin-induced thrombocytopenia 11.41 10.59 7 376029 4207 55911824
Salivary gland adenoma 11.41 10.59 4 376032 9 55916022
Mineral metabolism disorder 11.41 10.59 4 376032 9 55916022
Allergy to arthropod sting 11.40 10.59 9 376027 148 55915883
Gingival operation 11.39 10.59 8 376028 109 55915922
Haemangioma of liver 11.34 10.59 23 376013 1026 55915005
Periorbital oedema 11.34 10.59 11 376025 5243 55910788
Device deployment issue 11.32 10.59 5 376031 3619 55912412
Joint range of motion decreased 11.31 10.59 235 375801 25130 55890901
Fallopian tube disorder 11.31 10.59 14 376022 406 55915625
Post procedural hypothyroidism 11.30 10.59 9 376027 150 55915881
Bronchospasm 11.29 10.59 60 375976 15609 55900422
Blood prolactin increased 11.27 10.59 4 376032 3305 55912726
Cancer pain 11.26 10.59 3 376033 2983 55913048
Metaplasia 11.20 10.59 14 376022 410 55915621
Cutis laxa 11.20 10.59 9 376027 152 55915879
Fibroma 11.19 10.59 19 376017 739 55915292
Oesophageal irritation 11.15 10.59 8 376028 113 55915918
Pharyngo-oesophageal diverticulum 11.12 10.59 4 376032 10 55916021
Rheumatoid lung 11.10 10.59 46 375990 3094 55912937
Hepatitis toxic 11.07 10.59 3 376033 2949 55913082
Thinking abnormal 11.05 10.59 32 376004 9909 55906122
Diabetic neuropathy 11.04 10.59 52 375984 3696 55912335
Respiratory rate decreased 11.01 10.59 4 376032 3258 55912773
Gingival atrophy 10.98 10.59 5 376031 27 55916004
Stomatitis necrotising 10.97 10.59 8 376028 116 55915915
Urinary incontinence 10.96 10.59 267 375769 29318 55886713
Vertigo 10.94 10.59 279 375757 54293 55861738
Breast disorder female 10.91 10.59 8 376028 117 55915914
Antipsychotic drug level increased 10.90 10.59 4 376032 3238 55912793
Bone operation 10.90 10.59 11 376025 253 55915778
Papilloma 10.90 10.59 11 376025 253 55915778
Electroencephalogram abnormal 10.87 10.59 5 376031 3534 55912497
Borderline glaucoma 10.85 10.59 4 376032 11 55916020
Eczema 10.80 10.59 117 375919 26036 55889995
Blood pressure systolic decreased 10.79 10.59 16 376020 6327 55909704
Presyncope 10.75 10.59 114 375922 25468 55890563
Nervousness 10.74 10.59 133 375903 28882 55887149
Urinary tract disorder 10.70 10.59 40 375996 2564 55913467
Insurance issue 10.69 10.59 6 376030 3786 55912245
Bradypnoea 10.69 10.59 4 376032 3199 55912832
Biopsy lymph gland 10.69 10.59 5 376031 29 55916002
Faeces discoloured 10.68 10.59 68 375968 16928 55899103
Device related infection 10.67 10.59 94 375942 21786 55894245
Hepatic pain 10.65 10.59 3 376033 2875 55913156
Spinal pain 10.65 10.59 42 375994 11842 55904189
Influenza B virus test positive 10.63 10.59 11 376025 261 55915770
Euglycaemic diabetic ketoacidosis 10.61 10.59 4 376032 3185 55912846
Urine calcium decreased 10.60 10.59 4 376032 12 55916019

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis 388.14 10.68 230 38322 13654 31645138
Osteonecrosis of jaw 320.58 10.68 220 38332 16851 31641941
Femur fracture 270.39 10.68 147 38405 7386 31651406
Osteoporosis 184.37 10.68 135 38417 11448 31647344
Atypical femur fracture 170.89 10.68 45 38507 263 31658529
Low turnover osteopathy 168.63 10.68 36 38516 65 31658727
Osteomyelitis 130.71 10.68 122 38430 14521 31644271
Impaired healing 126.64 10.68 118 38434 14014 31644778
Toxicity to various agents 114.56 10.68 39 38513 181448 31477344
Dental caries 106.59 10.68 66 38486 4235 31654557
Intramedullary rod insertion 105.52 10.68 20 38532 11 31658781
Bone density decreased 104.11 10.68 48 38504 1687 31657105
Open reduction of fracture 101.13 10.68 24 38528 84 31658708
Atypical fracture 96.89 10.68 24 38528 105 31658687
Completed suicide 94.15 10.68 4 38548 91510 31567282
Drug abuse 86.57 10.68 5 38547 87753 31571039
Stress fracture 85.93 10.68 34 38518 813 31657979
Febrile neutropenia 78.91 10.68 25 38527 121824 31536968
Tooth disorder 71.66 10.68 74 38478 9955 31648837
Death 66.02 10.68 222 38330 360347 31298445
Blood parathyroid hormone decreased 65.33 10.68 32 38520 1290 31657502
Osteoarthritis 65.07 10.68 97 38455 18970 31639822
Periodontal disease 61.13 10.68 26 38526 751 31658041
Osteopenia 59.83 10.68 47 38505 4424 31654368
Rheumatoid arthritis 59.22 10.68 159 38393 47650 31611142
Tibia fracture 58.13 10.68 30 38522 1353 31657439
Hypophosphataemic osteomalacia 58.03 10.68 16 38536 114 31658678
Tooth fracture 55.36 10.68 40 38512 3319 31655473
Arthralgia 54.18 10.68 342 38210 151082 31507710
Tooth loss 54.03 10.68 41 38511 3667 31655125
Exostosis of jaw 53.13 10.68 14 38538 82 31658710
Exposed bone in jaw 53.10 10.68 29 38523 1468 31657324
Jaw disorder 51.94 10.68 32 38520 2034 31656758
Neutropenia 51.36 10.68 57 38495 140307 31518485
Gastrooesophageal reflux disease 50.65 10.68 121 38431 33750 31625042
Hypercalciuria 48.29 10.68 17 38535 290 31658502
Craniotabes 47.45 10.68 9 38543 5 31658787
Bone fissure 45.85 10.68 10 38542 21 31658771
Alanine aminotransferase abnormal 45.26 10.68 38 38514 3929 31654863
Red blood cell sedimentation rate 45.07 10.68 23 38529 1013 31657779
Fracture nonunion 44.59 10.68 14 38538 164 31658628
Jaw fracture 43.83 10.68 22 38530 935 31657857
Drug ineffective 43.27 10.68 293 38259 395280 31263512
Granuloma skin 43.16 10.68 23 38529 1108 31657684
Spinal compression fracture 42.81 10.68 46 38506 6476 31652316
Spinal fracture 42.45 10.68 47 38505 6841 31651951
Anaemia postoperative 41.32 10.68 17 38535 451 31658341
Internal fixation of fracture 39.70 10.68 11 38541 80 31658712
Arthropathy 39.33 10.68 89 38463 23962 31634830
Thrombocytopenia 39.27 10.68 71 38481 142676 31516116
Cataract 38.82 10.68 88 38464 23719 31635073
Exostosis 37.83 10.68 34 38518 3852 31654940
Blood immunoglobulin E increased 37.76 10.68 27 38525 2204 31656588
Sleep apnoea syndrome 37.48 10.68 75 38477 18550 31640242
Fall 37.47 10.68 368 38184 185721 31473071
Resorption bone increased 37.08 10.68 12 38540 156 31658636
Tooth abscess 36.28 10.68 38 38514 5194 31653598
Rheumatoid nodule 35.48 10.68 28 38524 2653 31656139
Foot fracture 35.22 10.68 34 38518 4217 31654575
Lumbar vertebral fracture 33.78 10.68 24 38528 1939 31656853
Oral infection 33.54 10.68 24 38528 1961 31656831
Dental fistula 33.37 10.68 10 38542 99 31658693
Panniculitis 33.34 10.68 23 38529 1773 31657019
Pain in jaw 33.05 10.68 56 38496 12199 31646593
Hyperlipidaemia 32.70 10.68 58 38494 13102 31645690
Spinal osteoarthritis 32.28 10.68 41 38511 6894 31651898
Temporomandibular joint syndrome 32.00 10.68 17 38535 814 31657978
Hypophosphatasia 31.42 10.68 8 38544 40 31658752
Medical device removal 31.41 10.68 10 38542 123 31658669
Pain 31.33 10.68 356 38196 186403 31472389
Device breakage 31.27 10.68 23 38529 1961 31656831
Pyrexia 31.22 10.68 229 38323 303611 31355181
Abscess jaw 31.07 10.68 16 38536 718 31658074
Asthma 30.97 10.68 118 38434 42493 31616299
Bone disorder 30.88 10.68 37 38515 5862 31652930
Infusion related reaction 30.85 10.68 128 38424 47927 31610865
Basal cell carcinoma 30.53 10.68 68 38484 18111 31640681
Synovitis 30.35 10.68 54 38498 12229 31646563
Hypotension 30.25 10.68 137 38415 204481 31454311
Pulmonary fibrosis 29.89 10.68 64 38488 16596 31642196
Periodontitis 29.87 10.68 22 38530 1880 31656912
Tendonitis 29.85 10.68 44 38508 8514 31650278
Intervertebral disc degeneration 29.26 10.68 35 38517 5536 31653256
Disease progression 28.62 10.68 41 38511 90423 31568369
Rib fracture 28.46 10.68 55 38497 13261 31645531
Vomiting 27.97 10.68 159 38393 223814 31434978
Nerve degeneration 27.96 10.68 10 38542 179 31658613
Leukopenia 27.84 10.68 18 38534 57810 31600982
Fibula fracture 27.69 10.68 15 38537 747 31658045
C-reactive protein abnormal 27.18 10.68 40 38512 7729 31651063
Thoracic vertebral fracture 26.80 10.68 19 38533 1530 31657262
COVID-19 26.48 10.68 17 38535 54804 31603988
Skin ulcer 26.29 10.68 68 38484 19917 31638875
Acute kidney injury 26.28 10.68 216 38336 279498 31379294
Periprosthetic fracture 25.81 10.68 9 38543 149 31658643
Tooth extraction 25.50 10.68 29 38523 4346 31654446
Hip fracture 25.49 10.68 47 38505 10939 31647853
Alveolar osteitis 25.46 10.68 8 38544 94 31658698
Bone metabolism disorder 25.31 10.68 10 38542 238 31658554
Joint ankylosis 25.31 10.68 16 38536 1064 31657728
Pulmonary vasculitis 24.61 10.68 11 38541 359 31658433
Nasal polyps 24.46 10.68 20 38532 1993 31656799
Gingival disorder 24.33 10.68 17 38535 1337 31657455
Dental necrosis 24.27 10.68 6 38546 26 31658766
Acetabulum fracture 24.21 10.68 10 38542 268 31658524
Nausea 23.68 10.68 250 38302 307697 31351095
Oesophageal ulcer 23.57 10.68 24 38528 3174 31655618
Suicide attempt 23.45 10.68 8 38544 37240 31621552
Obstructive airways disorder 23.12 10.68 49 38503 12615 31646177
Ankle fracture 22.72 10.68 25 38527 3614 31655178
Coma 22.40 10.68 11 38541 41139 31617653
Tongue disorder 22.31 10.68 29 38523 4988 31653804
Musculoskeletal disorder 22.19 10.68 31 38521 5713 31653079
Diverticulitis 22.06 10.68 61 38491 18584 31640208
Pathological fracture 22.02 10.68 26 38526 4056 31654736
Rhabdomyolysis 21.95 10.68 27 38525 63554 31595238
Scoliosis 21.93 10.68 21 38531 2578 31656214
Gingivitis 21.87 10.68 23 38529 3159 31655633
Bone cyst 21.86 10.68 15 38537 1146 31657646
Lactic acidosis 21.65 10.68 6 38546 31931 31626861
Ulcer 21.44 10.68 36 38516 7785 31651007
Renal mass 21.40 10.68 17 38535 1626 31657166
Tenosynovitis 21.37 10.68 26 38526 4184 31654608
Lumbar spinal stenosis 21.24 10.68 20 38532 2405 31656387
Fracture delayed union 20.94 10.68 6 38546 50 31658742
Gastritis 20.74 10.68 63 38489 20229 31638563
Bursitis 20.65 10.68 28 38524 5017 31653775
Bone loss 20.60 10.68 11 38541 532 31658260
Rhinitis 20.57 10.68 28 38524 5036 31653756
Central nervous system mass 20.36 10.68 7 38545 111 31658681
Back pain 20.35 10.68 213 38339 109200 31549592
Wall motion score index abnormal 20.30 10.68 7 38545 112 31658680
Respiratory symptom 20.27 10.68 15 38537 1291 31657501
Off label use 19.94 10.68 300 38252 346974 31311818
Kyphosis 19.91 10.68 14 38538 1113 31657679
Mobility decreased 19.90 10.68 76 38476 27393 31631399
Chronic sinusitis 19.80 10.68 17 38535 1812 31656980
Benign prostatic hyperplasia 19.73 10.68 47 38505 13078 31645714
Cardiac arrest 19.71 10.68 50 38502 89012 31569780
Polymyalgia rheumatica 19.66 10.68 15 38537 1352 31657440
Rheumatoid lung 19.54 10.68 12 38540 758 31658034
Renal cyst 19.52 10.68 36 38516 8380 31650412
Clumsiness 19.49 10.68 16 38536 1603 31657189
Blood pressure diastolic abnormal 19.27 10.68 24 38528 3955 31654837
Extraskeletal ossification 19.17 10.68 5 38547 28 31658764
Sequestrectomy 19.11 10.68 8 38544 222 31658570
Nasal septum deviation 19.01 10.68 13 38539 988 31657804
Corneal abrasion 18.47 10.68 8 38544 242 31658550
Calcium deficiency 18.45 10.68 7 38545 149 31658643
Oral cavity fistula 18.27 10.68 7 38545 153 31658639
Osteolysis 18.21 10.68 18 38534 2297 31656495
Pelvic cyst 18.21 10.68 5 38547 35 31658757
Cardiac septal defect 18.02 10.68 8 38544 257 31658535
Foetal exposure during pregnancy 17.99 10.68 14 38538 40862 31617930
White blood cell count decreased 17.88 10.68 51 38501 87347 31571445
Airway remodelling 17.86 10.68 7 38545 163 31658629
Enthesopathy 17.86 10.68 24 38528 4263 31654529
Hiatus hernia 17.75 10.68 31 38521 6916 31651876
Atopy 17.63 10.68 7 38545 169 31658623
Device failure 17.62 10.68 17 38535 2106 31656686
Arthritis 17.61 10.68 73 38479 27312 31631480
Pneumonectomy 17.21 10.68 5 38547 44 31658748
Dental prosthesis placement 17.14 10.68 3 38549 0 31658792
Poor dental condition 17.11 10.68 7 38545 183 31658609
Anti-cyclic citrullinated peptide antibody positive 17.03 10.68 14 38538 1406 31657386
Bone abscess 17.00 10.68 7 38545 186 31658606
Cardiac ablation 16.96 10.68 12 38540 963 31657829
Mouth swelling 16.90 10.68 15 38537 1671 31657121
Diarrhoea 16.77 10.68 315 38237 352094 31306698
Intentional product misuse 16.70 10.68 13 38539 37938 31620854
Oral disorder 16.38 10.68 22 38530 3905 31654887
Osteitis 16.31 10.68 14 38538 1492 31657300
Skin injury 16.15 10.68 15 38537 1772 31657020
Carpal tunnel syndrome 16.05 10.68 23 38529 4338 31654454
Nocturia 16.02 10.68 35 38517 9200 31649592
Fracture 16.02 10.68 28 38524 6252 31652540
Joint dislocation 15.97 10.68 20 38532 3315 31655477
Bronchiectasis 15.82 10.68 31 38521 7549 31651243
Pelvic fracture 15.80 10.68 17 38535 2396 31656396
Hypercholesterolaemia 15.75 10.68 32 38520 7998 31650794
Blood pressure fluctuation 15.73 10.68 62 38490 22674 31636118
Skin necrosis 15.65 10.68 26 38526 5572 31653220
Osteomalacia 15.48 10.68 11 38541 889 31657903
Chronic obstructive pulmonary disease 15.47 10.68 101 38451 45065 31613727
Loose tooth 15.45 10.68 12 38540 1111 31657681
Body temperature decreased 15.43 10.68 40 38512 11730 31647062
Restrictive pulmonary disease 15.37 10.68 12 38540 1119 31657673
Eosinophilic granulomatosis with polyangiitis 15.34 10.68 14 38538 1617 31657175
Psoriatic arthropathy 15.22 10.68 56 38496 19827 31638965
Joint injury 15.09 10.68 31 38521 7810 31650982
Compression fracture 15.08 10.68 18 38534 2839 31655953
Bone infarction 15.00 10.68 7 38545 253 31658539
Overdose 14.80 10.68 53 38499 84611 31574181
Femoral neck fracture 14.67 10.68 18 38534 2922 31655870
Renal neoplasm 14.63 10.68 12 38540 1201 31657591
Myelomalacia 14.61 10.68 5 38547 78 31658714
Dermal sinus 14.60 10.68 3 38549 4 31658788
Liver function test abnormal 14.51 10.68 73 38479 29619 31629173
Herpes zoster 14.48 10.68 77 38475 31916 31626876
Vertebroplasty 14.45 10.68 4 38548 29 31658763
Cellulitis 14.44 10.68 104 38448 47914 31610878
Sinus polyp 14.25 10.68 6 38546 169 31658623
Intervertebral disc protrusion 14.13 10.68 33 38519 9067 31649725
Oesophagitis 14.07 10.68 40 38512 12376 31646416
Penile erythema 14.02 10.68 6 38546 176 31658616
Limb asymmetry 13.90 10.68 5 38547 91 31658701
Red blood cell sedimentation rate increased 13.77 10.68 31 38521 8315 31650477
Eosinophilic myocarditis 13.57 10.68 8 38544 469 31658323
Microangiopathy 13.56 10.68 10 38542 856 31657936
Migraine 13.54 10.68 43 38509 14137 31644655
Enterocolitis bacterial 13.51 10.68 7 38545 318 31658474
Groin pain 13.50 10.68 23 38529 5030 31653762
Rhinitis allergic 13.48 10.68 17 38535 2837 31655955
Acute on chronic liver failure 13.47 10.68 5 38547 100 31658692
Blood pressure systolic increased 13.39 10.68 53 38499 19417 31639375
Erythrasma 13.31 10.68 4 38548 40 31658752
Animal scratch 13.14 10.68 6 38546 206 31658586
Neuritis 13.12 10.68 9 38543 687 31658105
Suicidal ideation 13.05 10.68 15 38537 36391 31622401
Loose body in joint 13.05 10.68 4 38548 43 31658749
Lung neoplasm 13.04 10.68 21 38531 4385 31654407
Bladder pain 12.92 10.68 8 38544 513 31658279
Urinary tract discomfort 12.86 10.68 5 38547 114 31658678
Fistula discharge 12.75 10.68 8 38544 525 31658267
Systemic lupus erythematosus 12.69 10.68 17 38535 3011 31655781
Idiopathic pulmonary fibrosis 12.66 10.68 20 38532 4110 31654682
Bronchoalveolar lavage 12.65 10.68 4 38548 48 31658744
JC virus CSF test positive 12.62 10.68 5 38547 120 31658672
Mycobacterium chelonae infection 12.59 10.68 9 38543 734 31658058
Langerhans' cell histiocytosis 12.58 10.68 4 38548 49 31658743
Wound complication 12.57 10.68 14 38538 2051 31656741
Actinic keratosis 12.48 10.68 20 38532 4159 31654633
Abdominal rigidity 12.42 10.68 11 38541 1222 31657570
Cardiac failure 12.40 10.68 58 38494 85895 31572897
Laryngeal ulceration 12.35 10.68 5 38547 127 31658665
Lower limb fracture 12.35 10.68 19 38533 3816 31654976
Lenticular opacities 12.34 10.68 6 38546 238 31658554
Fracture malunion 12.33 10.68 3 38549 12 31658780
Therapeutic product effect decreased 12.26 10.68 73 38479 31549 31627243
C-reactive protein increased 12.20 10.68 101 38451 48549 31610243
Oral pustule 12.18 10.68 6 38546 245 31658547
Nasopharyngitis 12.16 10.68 124 38428 63121 31595671
Renal failure 12.11 10.68 94 38458 123236 31535556
Pulpitis dental 11.98 10.68 7 38545 404 31658388
Small cell lung cancer 11.96 10.68 13 38539 1854 31656938
Dental plaque 11.95 10.68 3 38549 14 31658778
Diabetic ketoacidosis 11.79 10.68 3 38549 16902 31641890
Amino acid level increased 11.76 10.68 7 38545 418 31658374
Bronchitis 11.72 10.68 84 38468 38633 31620159
Rectal haemorrhage 11.72 10.68 80 38472 36224 31622568
Phlebosclerosis 11.71 10.68 5 38547 146 31658646
Granuloma 11.65 10.68 16 38536 2901 31655891
Drug interaction 11.64 10.68 181 38371 208362 31450430
Tooth impacted 11.54 10.68 4 38548 65 31658727
Eyelid disorder 11.35 10.68 7 38545 446 31658346
Aortic arteriosclerosis 11.33 10.68 19 38533 4104 31654688
Rotator cuff repair 11.22 10.68 6 38546 291 31658501
Bone erosion 11.16 10.68 17 38535 3386 31655406
Eosinophilic pustular folliculitis 11.11 10.68 4 38548 73 31658719
Sinus pain 11.11 10.68 8 38544 660 31658132
Neurotoxicity 11.09 10.68 3 38549 16223 31642569
Spinal fusion surgery 11.08 10.68 9 38543 888 31657904
Fracture displacement 11.06 10.68 4 38548 74 31658718
Gastric ulcer 11.02 10.68 41 38511 14593 31644199
Malignant neoplasm progression 10.99 10.68 54 38498 78944 31579848
Spondylolysis 10.96 10.68 4 38548 76 31658716
Jaw cyst 10.93 10.68 3 38549 21 31658771
Trismus 10.85 10.68 14 38538 2391 31656401
Tunnel vision 10.84 10.68 7 38545 483 31658309
Peripheral sensorimotor neuropathy 10.79 10.68 11 38541 1457 31657335
Spondylolisthesis 10.75 10.68 8 38544 694 31658098
Osteoradionecrosis 10.73 10.68 4 38548 81 31658711
Influenza like illness 10.69 10.68 60 38492 25377 31633415
Malignant neoplasm of thymus 10.69 10.68 3 38549 23 31658769
Abscess oral 10.68 10.68 6 38546 321 31658471
Bladder diverticulum 10.68 10.68 4 38548 82 31658710
Eosinophilic bronchitis 10.68 10.68 5 38547 182 31658610

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Femur fracture 3870.67 10.39 2193 288827 33939 70603485
Osteonecrosis of jaw 2823.75 10.39 1877 289143 39125 70598299
Osteonecrosis 2533.22 10.39 1546 289474 27614 70609810
Atypical femur fracture 1564.63 10.39 629 290391 4214 70633210
Pemphigus 1543.89 10.39 1802 289218 81234 70556190
Systemic lupus erythematosus 1405.86 10.39 1905 289115 99997 70537427
Glossodynia 1349.69 10.39 1718 289302 84769 70552655
Low turnover osteopathy 1322.62 10.39 434 290586 1448 70635976
Hand deformity 1285.41 10.39 1677 289343 84805 70552619
Arthropathy 1207.62 10.39 2189 288831 147868 70489556
Impaired healing 1175.51 10.39 1487 289533 72887 70564537
Stress fracture 1143.94 10.39 533 290487 5317 70632107
Osteomyelitis 1129.38 10.39 961 290059 29357 70608067
Pericarditis 1041.86 10.39 1499 289521 83206 70554218
Dental caries 1038.70 10.39 619 290401 10552 70626872
Anti-cyclic citrullinated peptide antibody positive 1033.42 10.39 1355 289665 68830 70568594
Toxicity to various agents 986.69 10.39 187 290833 381985 70255439
Wound 980.67 10.39 1582 289438 97150 70540274
Tooth disorder 843.24 10.39 735 290285 23203 70614221
Abdominal discomfort 830.93 10.39 2340 288680 212318 70425106
Synovitis 824.95 10.39 1710 289310 127518 70509906
Alopecia 800.98 10.39 2197 288823 196293 70441131
Jaw disorder 771.71 10.39 381 290639 4365 70633059
Death 771.18 10.39 581 290439 509480 70127944
Duodenal ulcer perforation 757.21 10.39 990 290030 50122 70587302
Completed suicide 751.91 10.39 45 290975 227090 70410334
Discomfort 735.73 10.39 1448 289572 103988 70533436
Helicobacter infection 710.67 10.39 1003 290017 54653 70582771
Osteoarthritis 704.75 10.39 1165 289855 72982 70564442
Oral infection 691.92 10.39 366 290654 4893 70632531
Swelling 639.10 10.39 1961 289059 186578 70450846
Acute kidney injury 616.24 10.39 624 290396 474000 70163424
Fracture nonunion 580.39 10.39 221 290799 1253 70636171
Infusion related reaction 563.31 10.39 1937 289083 195597 70441827
Contraindicated product administered 537.56 10.39 1485 289535 133127 70504297
Febrile neutropenia 530.91 10.39 98 290922 204220 70433204
Drug intolerance 529.92 10.39 2078 288942 223609 70413815
Exostosis of jaw 527.86 10.39 195 290825 1002 70636422
Neutropenia 515.49 10.39 205 290815 256951 70380473
Irritable bowel syndrome 507.51 10.39 817 290203 50033 70587391
Drug abuse 506.60 10.39 23 290997 147233 70490191
Tooth fracture 503.93 10.39 388 290632 10239 70627185
Bone disorder 500.46 10.39 478 290542 17012 70620412
Rheumatoid arthritis 499.25 10.39 2443 288577 289362 70348062
Temporomandibular joint syndrome 492.85 10.39 257 290763 3330 70634094
Rheumatoid factor positive 490.38 10.39 783 290237 47617 70589807
Hepatic enzyme increased 474.37 10.39 1570 289450 155420 70482004
Therapeutic product effect decreased 459.82 10.39 1461 289559 141557 70495867
Muscle injury 456.58 10.39 670 290350 37824 70599600
Hypotension 432.72 10.39 618 290402 403763 70233661
Off label use 427.37 10.39 1590 289430 741470 69895954
Hypersensitivity 418.14 10.39 1959 289061 227853 70409571
Gingival disorder 414.84 10.39 226 290794 3216 70634208
Drug interaction 411.99 10.39 579 290441 380862 70256562
Folliculitis 407.19 10.39 671 290349 41899 70595525
Hyperlipidaemia 406.96 10.39 496 290524 23367 70614057
Exostosis 397.12 10.39 385 290635 13960 70623464
Bone density decreased 391.38 10.39 346 290674 11128 70626296
Adverse event 385.07 10.39 712 290308 48749 70588675
Periodontal disease 378.35 10.39 171 290849 1579 70635845
Thrombocytopenia 375.37 10.39 261 290759 238849 70398575
Pathological fracture 371.62 10.39 311 290709 9272 70628152
Sleep disorder due to general medical condition, insomnia type 363.21 10.39 579 290441 35153 70602271
Tooth loss 360.63 10.39 260 290760 6190 70631234
Joint swelling 359.70 10.39 2014 289006 251197 70386227
Maternal exposure during pregnancy 355.85 10.39 1162 289858 114183 70523241
Intentional overdose 353.51 10.39 11 291009 98424 70539000
Blood cholesterol increased 352.58 10.39 803 290217 63801 70573623
Blister 349.93 10.39 1056 289964 99470 70537954
Anaemia postoperative 346.99 10.39 162 290858 1623 70635801
Gastrooesophageal reflux disease 339.79 10.39 979 290041 89860 70547564
Intervertebral disc degeneration 336.76 10.39 347 290673 13553 70623871
Osteoporosis 335.21 10.39 667 290353 48240 70589184
Vomiting 330.24 10.39 1285 289735 591826 70045598
Blood parathyroid hormone decreased 315.55 10.39 276 290744 8748 70628676
Spinal osteoarthritis 313.44 10.39 350 290670 14998 70622426
Bone loss 308.25 10.39 165 290855 2262 70635162
Bursitis 307.27 10.39 458 290562 26215 70611209
Cardiac arrest 306.31 10.39 136 290884 159698 70477726
Osteopenia 305.95 10.39 360 290660 16337 70621087
Nausea 302.99 10.39 2152 288868 849936 69787488
Arthralgia 300.36 10.39 3270 287750 500120 70137304
Disease progression 299.16 10.39 134 290886 156538 70480886
Jaw fracture 298.41 10.39 170 290850 2651 70634773
Resorption bone increased 298.37 10.39 135 290885 1250 70636174
Diarrhoea 297.47 10.39 1940 289080 781401 69856023
Fracture delayed union 295.75 10.39 152 290868 1907 70635517
Granuloma skin 284.91 10.39 243 290777 7439 70629985
Foot fracture 284.49 10.39 376 290644 19224 70618200
Tooth abscess 279.76 10.39 322 290698 14267 70623157
Adverse drug reaction 276.71 10.39 650 290370 52694 70584730
Rheumatoid nodule 272.99 10.39 323 290697 14744 70622680
Loose tooth 269.17 10.39 162 290858 2812 70634612
Oral disorder 261.68 10.39 251 290769 8978 70628446
Panniculitis 259.50 10.39 267 290753 10409 70627015
Product dose omission issue 258.32 10.39 307 290713 217161 70420263
Atypical fracture 256.28 10.39 98 290922 563 70636861
COVID-19 247.66 10.39 64 290956 105693 70531731
Suicide attempt 242.39 10.39 23 290997 79487 70557937
Gingivitis 240.33 10.39 228 290792 8042 70629382
Spondylolisthesis 238.31 10.39 149 290871 2777 70634647
Diverticulum 234.08 10.39 285 290735 13408 70624016
Hip arthroplasty 232.62 10.39 415 290605 27625 70609799
Periodontitis 231.82 10.39 170 290850 4158 70633266
Malignant neoplasm progression 227.90 10.39 107 290913 121632 70515792
Hypercholesterolaemia 224.49 10.39 322 290698 17795 70619629
Hip fracture 223.89 10.39 410 290610 27853 70609571
Rheumatic fever 221.94 10.39 316 290704 17344 70620080
Edentulous 221.09 10.39 69 290951 186 70637238
Cardio-respiratory arrest 219.02 10.39 70 290950 100607 70536817
Oral cavity fistula 217.89 10.39 88 290932 597 70636827
Pyrexia 215.61 10.39 1532 289488 605420 70032004
Device failure 213.19 10.39 183 290837 5652 70631772
Sepsis 206.20 10.39 434 290586 244111 70393313
Gastrointestinal disorder 200.48 10.39 911 290109 104516 70532908
Basal cell carcinoma 199.72 10.39 433 290587 33265 70604159
Platelet count decreased 199.68 10.39 263 290757 177959 70459465
Uterine disorder 199.53 10.39 116 290904 1883 70635541
Ulcer 196.97 10.39 368 290652 25386 70612038
Knee arthroplasty 193.38 10.39 432 290588 33869 70603555
Exposed bone in jaw 186.93 10.39 138 290882 3411 70634013
Scoliosis 184.45 10.39 177 290843 6334 70631090
Swollen joint count increased 183.86 10.39 253 290767 13447 70623977
White blood cell count decreased 182.62 10.39 259 290761 169882 70467542
Vitamin D deficiency 181.91 10.39 240 290780 12247 70625177
Tonsillar disorder 181.35 10.39 89 290931 1005 70636419
Seizure 177.39 10.39 285 290735 177677 70459747
Rib fracture 176.34 10.39 348 290672 25008 70612416
Fistula discharge 175.23 10.39 88 290932 1048 70636376
Multiple organ dysfunction syndrome 174.75 10.39 115 290905 108400 70529024
Cataract 174.55 10.39 564 290456 55081 70582343
Rotator cuff syndrome 173.67 10.39 237 290783 12497 70624927
Pneumonia 173.41 10.39 1588 289432 594644 70042780
Abscess jaw 173.33 10.39 100 290920 1599 70635825
Fibrocystic breast disease 173.06 10.39 72 290948 532 70636892
Fall 171.97 10.39 2666 288354 441430 70195994
Spinal compression fracture 171.92 10.39 262 290758 15291 70622133
Pain 170.81 10.39 3569 287451 625247 70012177
Osteitis 170.40 10.39 134 290886 3649 70633775
Fracture displacement 169.43 10.39 88 290932 1130 70636294
Lactic acidosis 169.16 10.39 31 290989 64993 70572431
Pelvic fracture 168.02 10.39 219 290801 11042 70626382
Tibia fracture 165.33 10.39 147 290873 4763 70632661
Renal failure 164.03 10.39 330 290690 188740 70448684
Cerumen impaction 162.47 10.39 85 290935 1109 70636315
Skin necrosis 161.44 10.39 261 290759 16030 70621394
Contusion 159.88 10.39 985 290035 127051 70510373
Asthenia 158.50 10.39 1163 289857 456503 70180921
Intentional product misuse 158.39 10.39 64 290956 79531 70557893
Pancytopenia 158.24 10.39 234 290786 150873 70486551
Overdose 156.21 10.39 286 290734 169459 70467965
Dental fistula 156.17 10.39 64 290956 453 70636971
Intramedullary rod insertion 154.68 10.39 49 290971 141 70637283
Pain in jaw 152.87 10.39 453 290567 42216 70595208
Lower respiratory tract infection 151.26 10.39 879 290141 111034 70526390
Anaemia 151.03 10.39 1002 290018 402421 70235003
Respiratory failure 148.52 10.39 292 290728 168443 70468981
Hiatus hernia 148.10 10.39 291 290729 20843 70616581
Tendonitis 147.10 10.39 298 290722 21824 70615600
Breast disorder 145.65 10.39 94 290926 1855 70635569
Hyperhidrosis 144.49 10.39 197 290823 131389 70506035
Stomatitis 144.04 10.39 962 290058 127549 70509875
Leukopenia 143.73 10.39 135 290885 106425 70530999
Type 2 diabetes mellitus 143.00 10.39 452 290568 43628 70593796
Ill-defined disorder 142.98 10.39 522 290498 54219 70583205
Ulna fracture 142.49 10.39 74 290946 950 70636474
Electrocardiogram QT prolonged 140.69 10.39 84 290936 83433 70553991
Muscle strain 138.77 10.39 175 290845 8535 70628889
Drug tolerance decreased 138.64 10.39 186 290834 9647 70627777
Respiratory arrest 137.56 10.39 27 290993 53906 70583518
Foot deformity 137.06 10.39 278 290742 20377 70617047
Dental necrosis 136.19 10.39 43 290977 122 70637302
Product use issue 135.01 10.39 1227 289793 178710 70458714
Infection 134.88 10.39 1390 289630 209395 70428029
Haemorrhoids 133.97 10.39 313 290707 25275 70612149
Neutrophil count decreased 131.24 10.39 91 290929 83465 70553959
Lumbar spinal stenosis 130.85 10.39 129 290891 4774 70632650
Radius fracture 130.80 10.39 108 290912 3158 70634266
Large intestine polyp 130.65 10.39 196 290824 11280 70626144
Stress urinary incontinence 130.43 10.39 83 290937 1597 70635827
Septic shock 129.47 10.39 162 290858 112096 70525328
Sedation 128.87 10.39 19 291001 46712 70590712
Fibromyalgia 128.83 10.39 461 290559 47413 70590011
Treatment failure 128.77 10.39 1022 289998 143120 70494304
Depressed level of consciousness 128.57 10.39 102 290918 87329 70550095
Abscess 127.68 10.39 270 290750 20384 70617040
Spinal fracture 127.37 10.39 234 290786 15933 70621491
Hyperaesthesia teeth 126.91 10.39 81 290939 1567 70635857
Drug reaction with eosinophilia and systemic symptoms 126.76 10.39 40 290980 57973 70579451
Rhabdomyolysis 126.02 10.39 124 290896 95636 70541788
Bradycardia 125.63 10.39 198 290822 124417 70513007
Kyphosis 125.13 10.39 93 290927 2323 70635101
Sinusitis 124.52 10.39 1149 289871 168046 70469378
Pulmonary embolism 124.39 10.39 285 290735 155582 70481842
Synovial cyst 124.23 10.39 166 290854 8576 70628848
Tachycardia 124.04 10.39 293 290727 158253 70479171
Hyperkalaemia 123.79 10.39 153 290867 106438 70530986
Periprosthetic fracture 123.67 10.39 57 290963 553 70636871
Hypercalcaemia 123.12 10.39 365 290655 34020 70603404
Fistula 122.68 10.39 185 290835 10696 70626728
Metabolic acidosis 122.13 10.39 77 290943 74269 70563155
Wrist fracture 121.71 10.39 181 290839 10335 70627089
Injection site pain 121.33 10.39 184 290836 117435 70519989
Mucosal inflammation 120.38 10.39 64 290956 67786 70569638
Skin ulcer 119.79 10.39 452 290568 47693 70589731
Agitation 119.35 10.39 124 290896 93251 70544173
Abscess oral 118.96 10.39 72 290948 1263 70636161
Meniscus injury 118.04 10.39 136 290884 6031 70631393
Lumbar radiculopathy 117.76 10.39 82 290938 1844 70635580
Encephalopathy 117.22 10.39 53 290967 61608 70575816
Alveolar osteitis 116.71 10.39 54 290966 529 70636895
Fibula fracture 116.50 10.39 101 290919 3162 70634262
Appendix disorder 116.40 10.39 76 290944 1531 70635893
Loss of consciousness 114.60 10.39 297 290723 155419 70482005
Arthritis 111.30 10.39 736 290284 97244 70540180
Blood creatinine increased 111.28 10.39 265 290755 142736 70494688
Dyspnoea 109.75 10.39 2368 288652 767692 69869732
Somnolence 109.62 10.39 483 290537 215123 70422301
Plasma cell myeloma 106.87 10.39 86 290934 73115 70564309
Ascites 106.83 10.39 73 290947 67474 70569950
Drug resistance 106.54 10.39 15 291005 38175 70599249
Haemoglobin decreased 106.49 10.39 456 290564 204703 70432721
Ligament sprain 105.62 10.39 182 290838 11781 70625643
Dehydration 105.31 10.39 523 290497 225619 70411805
Musculoskeletal stiffness 104.97 10.39 996 290024 146764 70490660
Hepatic failure 104.24 10.39 53 290967 57572 70579852
Gingival bleeding 103.44 10.39 207 290813 15025 70622399
Pulpitis dental 101.87 10.39 60 290960 999 70636425
Anaphylactic reaction 101.07 10.39 95 290925 74879 70562545
Intervertebral disc protrusion 100.75 10.39 252 290768 21251 70616173
Psoriasis 99.58 10.39 156 290864 98277 70539147
Atrophic vulvovaginitis 99.27 10.39 62 290958 1153 70636271
Cystocele 99.15 10.39 52 290968 682 70636742
Patellofemoral pain syndrome 98.59 10.39 45 290975 426 70636998
Sopor 98.12 10.39 8 291012 31259 70606165
Jaw operation 96.55 10.39 53 290967 766 70636658
Cardiac failure 95.79 10.39 287 290733 143254 70494170
Fractured sacrum 95.72 10.39 66 290954 1460 70635964
Neoplasm progression 95.62 10.39 33 290987 45195 70592229
Osteoradionecrosis 95.56 10.39 30 290990 83 70637341
Flushing 95.35 10.39 118 290902 82054 70555370
Lower limb fracture 94.26 10.39 211 290809 16561 70620863
Wrong technique in product usage process 93.84 10.39 86 290934 68612 70568812
Hepatocellular injury 93.44 10.39 36 290984 46055 70591369
Oesophagitis 93.35 10.39 253 290767 22399 70615025
Joint effusion 92.98 10.39 200 290820 15277 70622147
Tremor 92.20 10.39 328 290692 155296 70482128
Bone lesion 91.16 10.39 112 290908 5318 70632106
Red blood cell sedimentation rate 90.17 10.39 106 290914 4804 70632620
Rhinitis allergic 89.50 10.39 147 290873 9148 70628276
Intentional self-injury 89.31 10.39 12 291008 31638 70605786
Carpal tunnel syndrome 88.58 10.39 208 290812 16849 70620575
Pulmonary oedema 88.48 10.39 125 290895 82153 70555271
Aggression 88.46 10.39 44 290976 48402 70589022
Tooth extraction 88.23 10.39 153 290867 9954 70627470
Renal impairment 87.53 10.39 300 290720 143637 70493787
Bone marrow failure 87.28 10.39 46 290974 48964 70588460
Tenosynovitis 86.73 10.39 183 290837 13793 70623631
Toothache 85.31 10.39 215 290805 18215 70619209
Drug ineffective for unapproved indication 85.22 10.39 26 290994 38512 70598912
Femoral neck fracture 84.02 10.39 141 290879 8932 70628492
Nasal septum deviation 84 10.39 63 290957 1596 70635828
Mitral valve prolapse 83.60 10.39 67 290953 1876 70635548
Compression fracture 83.38 10.39 113 290907 5918 70631506
Gingival recession 82.95 10.39 54 290966 1082 70636342
Calcium deficiency 82.71 10.39 47 290973 729 70636695
Actinomycosis 82.44 10.39 51 290969 932 70636492
Cytokine release syndrome 82.42 10.39 7 291013 26460 70610964
Cytomegalovirus infection 82.36 10.39 30 290990 39728 70597696
Feeling abnormal 82.29 10.39 303 290717 142016 70495408
Product use in unapproved indication 82.26 10.39 506 290514 206972 70430452
Sciatica 82.14 10.39 255 290765 24372 70613052
Oedema mouth 82.04 10.39 79 290941 2839 70634585
Osteomyelitis chronic 81.95 10.39 44 290976 607 70636817
Radiculopathy 81.66 10.39 112 290908 5933 70631491
Oesophageal ulcer 81.29 10.39 116 290904 6378 70631046
Blood glucose increased 80.77 10.39 190 290830 102792 70534632
Lung neoplasm 80.37 10.39 115 290905 6339 70631085
Joint dislocation 79.65 10.39 181 290839 14350 70623074
Seborrhoeic keratosis 79.38 10.39 67 290953 2021 70635403
Tenosynovitis stenosans 78.85 10.39 70 290950 2263 70635161
Hospitalisation 78.72 10.39 136 290884 82432 70554992
Eustachian tube dysfunction 76.66 10.39 33 290987 268 70637156
Jaw cyst 76.61 10.39 27 290993 118 70637306
Carotid bruit 76.47 10.39 43 290977 653 70636771
Neurotoxicity 75.91 10.39 15 291005 29811 70607613
Cardiogenic shock 75.88 10.39 27 290993 36280 70601144
Limb asymmetry 75.78 10.39 40 290980 532 70636892
Myelosuppression 74.98 10.39 16 291004 30129 70607295
Rectocele 74.87 10.39 40 290980 546 70636878
Abortion spontaneous 74.81 10.39 10 291010 26469 70610955
Oroantral fistula 74.42 10.39 35 290985 357 70637067
Clostridium difficile infection 74.35 10.39 33 290987 38783 70598641
Premature delivery 74.31 10.39 3 291017 21301 70616123
Cholestasis 74.03 10.39 53 290967 47819 70589605
Bone sequestrum 73.70 10.39 51 290969 1135 70636289
Diabetic ketoacidosis 71.99 10.39 20 291000 31492 70605932
Hypoglycaemia 71.71 10.39 177 290843 94187 70543237
Anaphylactic shock 71.69 10.39 22 290998 32468 70604956
Accidental exposure to product 71.62 10.39 14 291006 28037 70609387
Myocardial infarction 71.52 10.39 412 290608 171233 70466191
Sinus disorder 71.46 10.39 205 290815 18754 70618670
Trismus 71.31 10.39 96 290924 4995 70632429
Cognitive disorder 71.28 10.39 87 290933 60869 70576555
Suicidal ideation 70.67 10.39 110 290910 69486 70567938
Varicose vein 70.67 10.39 85 290935 3947 70633477
Unevaluable event 70.13 10.39 66 290954 51997 70585427
Sjogren's syndrome 69.80 10.39 41 290979 679 70636745
Peripheral swelling 69.62 10.39 1360 289660 235203 70402221
Cardiac murmur 68.14 10.39 153 290867 12033 70625391
Angioedema 67.91 10.39 105 290915 66505 70570919
Blood bilirubin increased 67.43 10.39 88 290932 59813 70577611
Abnormal behaviour 67.28 10.39 29 290991 34680 70602744
Bone fragmentation 67.01 10.39 38 290982 587 70636837
Red blood cell sedimentation rate increased 66.87 10.39 325 290695 38317 70599107
Pleural effusion 66.67 10.39 299 290721 132565 70504859
Polymyalgia rheumatica 66.61 10.39 81 290939 3805 70633619
Abdominal pain 66.60 10.39 995 290025 341132 70296292
Hepatotoxicity 66.33 10.39 50 290970 43936 70593488
Toxic epidermal necrolysis 66.31 10.39 40 290980 39517 70597907
Psoriatic arthropathy 66.10 10.39 474 290546 64297 70573127
Restlessness 65.99 10.39 46 290974 42082 70595342
Tooth deposit 65.68 10.39 29 290991 252 70637172
Headache 65.53 10.39 1847 289173 578558 70058866
Inflammation 65.47 10.39 549 290471 78116 70559308
Gastritis 65.33 10.39 358 290662 44233 70593191
Status epilepticus 65.30 10.39 11 291009 24515 70612909
COVID-19 pneumonia 65.26 10.39 7 291013 21962 70615462
Osteonecrosis of external auditory canal 65.17 10.39 23 290997 101 70637323
Epistaxis 65.06 10.39 210 290810 102417 70535007
Posterior reversible encephalopathy syndrome 64.84 10.39 11 291009 24391 70613033
Spinal disorder 64.65 10.39 127 290893 9093 70628331
Serotonin syndrome 64.63 10.39 47 290973 42067 70595357
Peripheral venous disease 64.08 10.39 138 290882 10549 70626875
Dental plaque 64.00 10.39 21 290999 70 70637354
Epilepsy 63.92 10.39 40 290980 38744 70598680
Rash maculo-papular 63.60 10.39 68 290952 50477 70586947
Injection site erythema 63.43 10.39 127 290893 72797 70564627
Sequestrectomy 63.40 10.39 41 290979 812 70636612
Thoracic vertebral fracture 63.24 10.39 88 290932 4726 70632698
Tongue disorder 63.01 10.39 156 290864 13071 70624353
Poisoning 62.83 10.39 9 291011 22613 70614811
Gingival pain 62.56 10.39 105 290915 6652 70630772
Acute sinusitis 62.52 10.39 82 290938 4159 70633265
Rash erythematous 62.41 10.39 72 290948 51646 70585778
Palmar-plantar erythrodysaesthesia syndrome 62.35 10.39 23 290997 30224 70607200
Facet joint syndrome 62.02 10.39 99 290921 6014 70631410
Mastication disorder 61.78 10.39 63 290957 2429 70634995
Acute myocardial infarction 61.64 10.39 129 290891 72758 70564666
Enthesopathy 61.37 10.39 137 290883 10732 70626692
Bruxism 61.13 10.39 76 290944 3653 70633771
Acute respiratory distress syndrome 60.80 10.39 48 290972 41206 70596218
Weight decreased 60.76 10.39 902 290118 309586 70327838
Generalised tonic-clonic seizure 60.74 10.39 49 290971 41612 70595812
Spinal stenosis 60.71 10.39 164 290856 14489 70622935
Disturbance in attention 60.62 10.39 52 290968 42842 70594582
Tooth infection 60.11 10.39 176 290844 16287 70621137
Vertebral foraminal stenosis 60.09 10.39 43 290977 1011 70636413
Fracture 59.70 10.39 199 290821 19745 70617679
Purulence 59.69 10.39 56 290964 1947 70635477
Shock 59.62 10.39 47 290973 40378 70597046
Disorientation 59.34 10.39 91 290929 57832 70579592
Ankle fracture 58.89 10.39 167 290853 15177 70622247
Pericardial effusion 58.61 10.39 51 290969 41725 70595699
Hypoxia 58.48 10.39 192 290828 93152 70544272
Acute myeloid leukaemia 58.17 10.39 27 290993 30913 70606511
Tumour lysis syndrome 58.17 10.39 9 291011 21351 70616073
Road traffic accident 58.09 10.39 289 290731 34393 70603031
Renal cyst 57.97 10.39 152 290868 13193 70624231
Dermal sinus 57.67 10.39 15 291005 14 70637410
Acetabulum fracture 57.62 10.39 33 290987 520 70636904
Transaminases increased 57.23 10.39 65 290955 46953 70590471
Internal fixation of fracture 56.84 10.39 28 290992 319 70637105
Lumbar vertebral fracture 56.72 10.39 94 290926 5893 70631531
Neuroleptic malignant syndrome 56.69 10.39 18 291002 25989 70611435
Kyphoscoliosis 56.54 10.39 25 290995 218 70637206
Neutropenic sepsis 56.27 10.39 16 291004 24814 70612610
Bone formation decreased 55.55 10.39 18 291002 57 70637367
Skin discolouration 55.55 10.39 43 290977 37282 70600142
Bone metabolism disorder 55.52 10.39 31 290989 464 70636960
Cough 55.43 10.39 970 290050 324407 70313017
Hypervolaemia 55.07 10.39 49 290971 39657 70597767
Respiratory distress 54.89 10.39 87 290933 54563 70582861
Colitis 54.76 10.39 112 290908 63702 70573722
Postmenopause 54.39 10.39 14 291006 12 70637412
Mycotic allergy 53.85 10.39 41 290979 1063 70636361
Drug eruption 53.82 10.39 311 290709 39185 70598239
Decreased appetite 53.72 10.39 903 290117 303877 70333547
Brain oedema 53.24 10.39 15 291005 23403 70614021
Peptic ulcer 53.19 10.39 89 290931 5624 70631800
Accidental overdose 52.86 10.39 40 290980 35081 70602343
Malaise 52.62 10.39 1363 289657 431569 70205855
Oral fibroma 52.40 10.39 14 291006 16 70637408
Breast calcifications 52.38 10.39 36 290984 792 70636632
Dystonia 52.10 10.39 9 291011 19697 70617727
Pneumonitis 51.97 10.39 90 290930 54507 70582917
Reversible airways obstruction 51.91 10.39 47 290973 1560 70635864
Scleritis 51.81 10.39 69 290951 3553 70633871
Psychotic disorder 51.72 10.39 47 290973 37654 70599770
Retinitis 51.62 10.39 74 290946 4086 70633338
Thyroid neoplasm 51.51 10.39 62 290958 2881 70634543
Haemorrhage 51.40 10.39 174 290846 83641 70553783
Blood creatine phosphokinase increased 51.32 10.39 109 290911 61154 70576270
Respiratory depression 50.99 10.39 19 291001 24812 70612612
Unresponsive to stimuli 50.91 10.39 84 290936 51847 70585577
Blood pressure decreased 50.83 10.39 198 290822 91317 70546107
Depressed mood 50.75 10.39 63 290957 43757 70593667
Joint injury 50.60 10.39 232 290788 26700 70610724
Hair follicle tumour benign 50.51 10.39 28 290992 413 70637011
Drug tolerance 50.50 10.39 101 290919 7327 70630097
Pancreatitis 50.44 10.39 114 290906 62554 70574870
Hyperbilirubinaemia 50.30 10.39 15 291005 22553 70614871
Iliotibial band syndrome 50.19 10.39 15 291005 33 70637391
Injection site swelling 50.03 10.39 62 290958 43095 70594329
Maternal exposure timing unspecified 49.99 10.39 75 290945 4316 70633108
Postmenopausal haemorrhage 49.76 10.39 44 290976 1415 70636009
Haemophagocytic lymphohistiocytosis 49.62 10.39 10 291010 19602 70617822
Barrett's oesophagus 49.35 10.39 34 290986 751 70636673
Hypertension 49.33 10.39 1576 289444 294457 70342967
Therapy interrupted 49.24 10.39 20 291000 24782 70612642
Patella fracture 49.01 10.39 46 290974 1600 70635824
Skeletal injury 48.99 10.39 41 290979 1222 70636202
Ventricular fibrillation 48.93 10.39 25 290995 27086 70610338
Dysarthria 48.83 10.39 115 290905 62198 70575226
Aortic arteriosclerosis 48.78 10.39 103 290917 7766 70629658
Bacteraemia 48.62 10.39 30 290990 29279 70608145
Acquired oesophageal web 48.52 10.39 24 290996 276 70637148
Pallor 48.41 10.39 58 290962 40916 70596508
Drug level increased 48.22 10.39 47 290973 36422 70601002
Aphasia 48.21 10.39 64 290956 43185 70594239
Withdrawal syndrome 47.97 10.39 21 290999 24883 70612541
Oesophageal stenosis 47.90 10.39 70 290950 3934 70633490
Eosinophilia 47.72 10.39 57 290963 40262 70597162
Back disorder 47.61 10.39 122 290898 10442 70626982
Feeling hot 47.46 10.39 79 290941 48591 70588833
Bladder disorder 47.39 10.39 105 290915 8184 70629240
Osteogenesis imperfecta 47.15 10.39 22 290998 220 70637204
Oral pain 47.13 10.39 240 290780 28826 70608598
Hepatitis 47.02 10.39 83 290937 49897 70587527
Dyskinesia 46.58 10.39 60 290960 41014 70596410
Irritability 46.36 10.39 53 290967 38172 70599252
Anaemia of chronic disease 46.27 10.39 53 290967 2335 70635089
Therapy cessation 46.17 10.39 42 290978 33634 70603790
Product prescribing error 46.17 10.39 55 290965 38897 70598527
Haematochezia 45.99 10.39 150 290870 72931 70564493
Synovial fluid analysis 45.88 10.39 47 290973 1822 70635602
Mydriasis 45.87 10.39 6 291014 16147 70621277
Gingival abscess 45.59 10.39 32 290988 729 70636695
Agranulocytosis 45.56 10.39 59 290961 40239 70597185
Oestrogen deficiency 45.38 10.39 16 291004 70 70637354
Device issue 45.11 10.39 21 290999 24004 70613420
Myoclonus 45.09 10.39 26 290994 26329 70611095
Steroid therapy 45.06 10.39 14 291006 37 70637387
Lymphocyte count decreased 44.98 10.39 68 290952 43471 70593953
Chest discomfort 44.88 10.39 312 290708 124069 70513355
Altered state of consciousness 44.84 10.39 59 290961 39963 70597461
Multiple sclerosis relapse 44.62 10.39 67 290953 42950 70594474
Rash 44.61 10.39 2540 288480 508022 70129402
Inappropriate schedule of product administration 44.34 10.39 259 290761 107296 70530128
Cervicobrachial syndrome 44.29 10.39 36 290984 1029 70636395
Open reduction of fracture 44.08 10.39 21 290999 221 70637203
Oxygen saturation decreased 44.03 10.39 288 290732 116141 70521283
Neuropathy peripheral 43.99 10.39 322 290698 126574 70510850
Dislocation of vertebra 43.85 10.39 75 290945 4825 70632599
Adjustment disorder with depressed mood 43.68 10.39 69 290951 4154 70633270
Acute hepatic failure 43.62 10.39 30 290990 27642 70609782
Hypothermia 43.58 10.39 15 291005 20579 70616845
Drug withdrawal syndrome 43.45 10.39 42 290978 32673 70604751
Thrombotic microangiopathy 43.33 10.39 10 291010 17838 70619586
Illness 43.17 10.39 40 290980 31751 70605673
Creatinine renal clearance decreased 43.04 10.39 9 291011 17191 70620233
Uterine prolapse 42.63 10.39 31 290989 748 70636676
Ventricular tachycardia 42.57 10.39 52 290968 36371 70601053
Dupuytren's contracture 42.49 10.39 13 291007 32 70637392
Lethargy 42.31 10.39 162 290858 75088 70562336
Humerus fracture 42.24 10.39 101 290919 8277 70629147
Dizziness 42.18 10.39 1519 289501 462622 70174802
Gingival swelling 42.07 10.39 67 290953 4062 70633362
Lumbosacral radiculopathy 41.99 10.39 25 290995 425 70636999
Plantar fasciitis 41.89 10.39 58 290962 3100 70634324
Oliguria 41.77 10.39 6 291014 15045 70622379
Drug ineffective 41.58 10.39 3307 287713 936445 69700979
Haematotoxicity 41.55 10.39 4 291016 13670 70623754
Osteomyelitis acute 41.53 10.39 25 290995 434 70636990
Mental status changes 41.48 10.39 127 290893 62974 70574450
Urinary tract discomfort 41.43 10.39 25 290995 436 70636988
Carotid artery disease 41.36 10.39 48 290972 2145 70635279
Aplastic anaemia 41.31 10.39 9 291011 16707 70620717
Spinal meningeal cyst 41.25 10.39 12 291008 23 70637401
Onychomycosis 41.25 10.39 89 290931 6812 70630612
Vital capacity decreased 41.23 10.39 39 290981 1370 70636054
Comminuted fracture 40.98 10.39 28 290992 610 70636814
Myocarditis 40.97 10.39 13 291007 18780 70618644
Ovarian disorder 40.89 10.39 25 290995 447 70636977
Intervertebral disc disorder 40.80 10.39 70 290950 4515 70632909
Laryngitis 40.79 10.39 136 290884 13495 70623929
Osteomalacia 40.65 10.39 39 290981 1395 70636029
Osteopetrosis 40.50 10.39 9 291011 0 70637424
Anuria 40.42 10.39 15 291005 19638 70617786
Morton's neuralgia 40.40 10.39 13 291007 40 70637384
Constipation 40.31 10.39 761 290259 251677 70385747
Red blood cell count decreased 40.28 10.39 97 290923 52064 70585360
Joint range of motion decreased 40.19 10.39 212 290808 25814 70611610
Depression 40.13 10.39 1085 289935 197889 70439535
Urge incontinence 40.13 10.39 34 290986 1031 70636393
Fluid retention 39.96 10.39 130 290890 63255 70574169
Malocclusion 39.94 10.39 16 291004 106 70637318
Labelled drug-drug interaction medication error 39.60 10.39 25 290995 24102 70613322
Chills 39.59 10.39 391 290629 144395 70493029
Injury 39.19 10.39 425 290595 64820 70572604
Upper limb fracture 38.99 10.39 150 290870 15969 70621455
Akathisia 38.98 10.39 3 291017 12290 70625134
Hepatic cytolysis 38.88 10.39 15 291005 19177 70618247
Traumatic ulcer 38.81 10.39 13 291007 47 70637377
Anti-cyclic citrullinated peptide antibody 38.80 10.39 58 290962 3327 70634097
Skin exfoliation 38.69 10.39 89 290931 48537 70588887
Incorrect dose administered 38.57 10.39 142 290878 66577 70570847
Nocturia 38.53 10.39 124 290896 12080 70625344
Goitre 38.48 10.39 73 290947 5093 70632331
Alanine aminotransferase abnormal 38.33 10.39 95 290925 7964 70629460
Melanocytic naevus 38.32 10.39 66 290954 4270 70633154
Benign neoplasm of skin 38.14 10.39 15 291005 94 70637330
Hypokalaemia 38.11 10.39 349 290671 130839 70506585
Dermal cyst 38.06 10.39 49 290971 2440 70634984
Dental alveolar anomaly 37.84 10.39 11 291009 21 70637403
Gamma-glutamyltransferase increased 37.77 10.39 96 290924 50589 70586835
Hemiparesis 37.76 10.39 44 290976 31425 70605999
Syncope 37.57 10.39 467 290553 165242 70472182
Pathogen resistance 37.55 10.39 5 291015 13274 70624150
Bone fistula 37.42 10.39 14 291006 75 70637349
Hallucination 37.41 10.39 173 290847 76087 70561337
Breast mass 37.36 10.39 77 290943 5708 70631716
Hyperthermia 37.30 10.39 11 291009 16660 70620764
Stevens-Johnson syndrome 37.17 10.39 56 290964 35851 70601573
Raynaud's phenomenon 37.09 10.39 32 290988 995 70636429
Therapy partial responder 36.99 10.39 4 291016 12470 70624954
Vaginal disorder 36.78 10.39 24 290996 483 70636941
Renal tubular necrosis 36.69 10.39 25 290995 23146 70614278
Cerebral haemorrhage 36.41 10.39 107 290913 53757 70583667
Haematocrit decreased 36.39 10.39 117 290903 57141 70580283
Peripheral vascular disorder 36.34 10.39 90 290930 7542 70629882
Miosis 36.08 10.39 7 291013 14094 70623330
Device dislocation 36.02 10.39 24 290996 22483 70614941
Trigger finger 35.96 10.39 59 290961 3668 70633756
Dry skin 35.75 10.39 114 290906 55817 70581607
Nasopharyngitis 35.70 10.39 1178 289842 221028 70416396
Dyslipidaemia 35.61 10.39 105 290915 9755 70627669
Spondylolysis 35.58 10.39 15 291005 115 70637309
Transplant rejection 35.51 10.39 15 291005 18156 70619268
Pulmonary arterial hypertension 35.23 10.39 50 290970 32805 70604619
Lip dry 35.14 10.39 104 290916 9681 70627743
Groin pain 35.02 10.39 119 290901 11923 70625501
Iron deficiency anaemia 34.98 10.39 187 290833 22885 70614539
Dementia Alzheimer's type 34.85 10.39 31 290989 1005 70636419
Menopausal symptoms 34.84 10.39 39 290981 1675 70635749
Coma 34.82 10.39 227 290793 91617 70545807
Skin laceration 34.76 10.39 203 290817 25675 70611749
International normalised ratio increased 34.56 10.39 192 290828 80534 70556890
Cardiac failure congestive 34.49 10.39 372 290648 135085 70502339
Haemodialysis 34.48 10.39 14 291006 17352 70620072
Pain in extremity 34.42 10.39 1661 289359 326421 70311003
Oesophageal disorder 34.36 10.39 47 290973 2483 70634941
Jaw fistula 34.29 10.39 14 291006 98 70637326
Cardiotoxicity 34.27 10.39 3 291017 11067 70626357
Haemoptysis 34.21 10.39 103 290917 51349 70586075
Immune reconstitution inflammatory syndrome 34.20 10.39 6 291014 12984 70624440
Atrial fibrillation 34.16 10.39 541 290479 183807 70453617
Atrophy 33.73 10.39 41 290979 1925 70635499
Adenoidal disorder 33.71 10.39 15 291005 133 70637291
Renal injury 33.58 10.39 12 291008 16082 70621342
Hepatic encephalopathy 33.53 10.39 25 290995 22093 70615331
Tooth impacted 33.52 10.39 15 291005 135 70637289
Animal scratch 33.51 10.39 32 290988 1138 70636286
Graft versus host disease 33.46 10.39 10 291010 15013 70622411
Pancreatitis acute 33.44 10.39 86 290934 45138 70592286
Chronic sinusitis 33.43 10.39 93 290927 8358 70629066
Uterine leiomyoma 33.42 10.39 73 290947 5634 70631790
Diverticulum intestinal 33.32 10.39 90 290930 7951 70629473
Actinic keratosis 33.31 10.39 72 290948 5518 70631906
Product quality issue 33.27 10.39 46 290974 30515 70606909
Injection site mass 32.98 10.39 17 291003 18326 70619098
Toxic skin eruption 32.94 10.39 21 290999 20141 70617283
Angiopathy 32.93 10.39 79 290941 6488 70630936
Breast cyst 32.84 10.39 32 290988 1167 70636257
Bone graft 32.45 10.39 25 290995 660 70636764
Nightmare 32.37 10.39 26 290994 22130 70615294
Neuritis 32.26 10.39 34 290986 1363 70636061
Body height decreased 32.13 10.39 87 290933 7696 70629728
Bone formation increased 32.12 10.39 12 291008 64 70637360
Increased tendency to bruise 32.09 10.39 100 290920 9575 70627849
Extrapyramidal disorder 32.04 10.39 23 290997 20727 70616697
Deep vein thrombosis postoperative 32.00 10.39 55 290965 3552 70633872
End stage renal disease 31.94 10.39 4 291016 11129 70626295
Hormone level abnormal 31.81 10.39 38 290982 1752 70635672
Granuloma 31.76 10.39 86 290934 7609 70629815
Blood pressure increased 31.74 10.39 563 290457 187954 70449470
Therapeutic response shortened 31.55 10.39 7 291013 12831 70624593
Gingival ulceration 31.53 10.39 27 290993 831 70636593
Aspergillus infection 31.47 10.39 17 291003 17851 70619573
Hemiplegia 31.40 10.39 9 291011 13886 70623538
Orthostatic hypotension 31.33 10.39 108 290912 51635 70585789
Ear pain 31.12 10.39 207 290813 27392 70610032
Muscle rigidity 31.06 10.39 19 291001 18631 70618793
Poor dental condition 31.05 10.39 22 290998 509 70636915
Ischaemic stroke 31.01 10.39 49 290971 30771 70606653
X-ray of pelvis and hip abnormal 31.00 10.39 8 291012 7 70637417
Traumatic fracture 30.99 10.39 27 290993 851 70636573
Liver injury 30.81 10.39 280 290740 40755 70596669
Shock haemorrhagic 30.78 10.39 18 291002 18088 70619336
Emphysema 30.76 10.39 133 290887 14927 70622497
Injection site bruising 30.75 10.39 69 290951 37963 70599461
Neutrophil count increased 30.53 10.39 39 290981 26756 70610668
Cyst 30.47 10.39 118 290902 12601 70624823
Blood urea increased 30.45 10.39 92 290928 45817 70591607
Hypophosphatasia 30.35 10.39 11 291009 53 70637371
Mammogram abnormal 30.20 10.39 20 291000 413 70637011
Pneumocystis jirovecii pneumonia 30.10 10.39 48 290972 30034 70607390
Dialysis 30.01 10.39 17 291003 17385 70620039
Ejection fraction decreased 29.93 10.39 50 290970 30712 70606712
Blood glucose decreased 29.84 10.39 33 290987 24126 70613298
Leukoplakia 29.76 10.39 12 291008 81 70637343
Cytopenia 29.76 10.39 17 291003 17306 70620118
Psychomotor hyperactivity 29.74 10.39 13 291007 15420 70622004
Osteitis deformans 29.55 10.39 15 291005 183 70637241
Glomerular filtration rate decreased 29.53 10.39 25 290995 20731 70616693
Bronchial secretion retention 29.51 10.39 48 290972 2962 70634462
Lacrimation increased 29.51 10.39 23 290997 19876 70617548
Electrocardiogram QRS complex prolonged 29.45 10.39 3 291017 9803 70627621
Torsade de pointes 29.42 10.39 19 291001 18097 70619327
Intermittent claudication 29.16 10.39 50 290970 3223 70634201
Live birth 29.15 10.39 123 290897 13656 70623768
Prescribed overdose 28.94 10.39 201 290819 26980 70610444
Hyponatraemia 28.92 10.39 472 290548 159615 70477809
Abdominal distension 28.88 10.39 282 290738 104387 70533037
Pulmonary haemorrhage 28.86 10.39 10 291010 13663 70623761
Phlebolith 28.79 10.39 11 291009 63 70637361
Nasal disorder 28.71 10.39 50 290970 3264 70634160
Enterocele 28.69 10.39 10 291010 42 70637382
Hyperglycaemia 28.68 10.39 152 290868 64520 70572904
Mood swings 28.59 10.39 20 291000 18266 70619158
Mood altered 28.55 10.39 16 291004 16459 70620965
Tooth resorption 28.39 10.39 9 291011 26 70637398
Extraskeletal ossification 28.37 10.39 11 291009 66 70637358
Bronchitis chronic 28.14 10.39 56 290964 4048 70633376
No adverse event 27.95 10.39 56 290964 32097 70605327
Arrhythmia 27.75 10.39 127 290893 56016 70581408
Klebsiella infection 27.61 10.39 12 291008 14280 70623144
Lipase increased 27.60 10.39 14 291006 15232 70622192
Hypomagnesaemia 27.54 10.39 81 290939 40683 70596741
Tachypnoea 27.44 10.39 47 290973 28591 70608833
Inappropriate antidiuretic hormone secretion 27.44 10.39 33 290987 23243 70614181
Hypercalciuria 27.35 10.39 20 291000 487 70636937
Upper-airway cough syndrome 27.28 10.39 95 290925 9636 70627788
Vascular calcification 27.08 10.39 27 290993 1013 70636411
Breast fibrosis 27.00 10.39 6 291014 0 70637424
Sialoadenitis 26.96 10.39 35 290985 1757 70635667
Dysgeusia 26.91 10.39 108 290912 49394 70588030
Hand fracture 26.90 10.39 65 290955 5362 70632062
Vulvovaginal dryness 26.75 10.39 35 290985 1771 70635653
Otitis externa 26.74 10.39 39 290981 2188 70635236
Disease recurrence 26.67 10.39 73 290947 37530 70599894
Hyperammonaemia 26.57 10.39 5 291015 10288 70627136
Osteoma 26.57 10.39 9 291011 34 70637390
Chronic obstructive pulmonary disease 26.51 10.39 457 290563 77184 70560240
Prostate cancer 26.47 10.39 55 290965 31108 70606316
Injection site pruritus 26.42 10.39 78 290942 39132 70598292
Trigeminal neuralgia 26.30 10.39 49 290971 3372 70634052
Thrombosis 26.29 10.39 191 290829 75214 70562210
Carotid artery stenosis 26.29 10.39 84 290936 8152 70629272
Anxiety disorder 26.24 10.39 53 290967 3872 70633552
Myofascial pain syndrome 26.21 10.39 35 290985 1807 70635617
Cardiac failure acute 26.21 10.39 20 291000 17467 70619957
Troponin increased 26.20 10.39 18 291002 16596 70620828
Purulent discharge 26.18 10.39 66 290954 5592 70631832
Tendon disorder 25.83 10.39 72 290948 6479 70630945
Blood lactate dehydrogenase increased 25.82 10.39 67 290953 35060 70602364
Ear disorder 25.81 10.39 49 290971 3420 70634004
Fracture malunion 25.81 10.39 12 291008 119 70637305
Blood lactic acid increased 25.69 10.39 7 291013 11166 70626258
Hypophagia 25.69 10.39 86 290934 41484 70595940
Paranoia 25.62 10.39 20 291000 17268 70620156
Cerebrovascular accident 25.59 10.39 424 290596 143046 70494378
Red cell distribution width increased 25.55 10.39 12 291008 13645 70623779
Disseminated intravascular coagulation 25.53 10.39 63 290957 33535 70603889
Metastases to central nervous system 25.48 10.39 15 291005 15019 70622405
Musculoskeletal pain 25.42 10.39 516 290504 89811 70547613
Peripheral sensory neuropathy 25.31 10.39 9 291011 12101 70625323
Bradyphrenia 25.31 10.39 5 291015 9941 70627483
Bronchitis 25.26 10.39 645 290375 116598 70520826
Tardive dyskinesia 25.25 10.39 5 291015 9924 70627500
Mixed incontinence 25.24 10.39 9 291011 41 70637383
Full blood count decreased 25.05 10.39 37 290983 23881 70613543
Acute respiratory failure 25.00 10.39 124 290896 53541 70583883
Arteriosclerosis coronary artery 24.98 10.39 132 290888 16083 70621341
Thalassaemia beta 24.94 10.39 7 291013 11 70637413
Loss of employment 24.89 10.39 38 290982 2221 70635203
Proteinuria 24.82 10.39 52 290968 29322 70608102
Oesophageal discomfort 24.69 10.39 15 291005 265 70637159
Injection site reaction 24.50 10.39 113 290907 49739 70587685
Cervical polyp 24.49 10.39 12 291008 135 70637289
Rash macular 24.41 10.39 42 290978 25502 70611922
Colorectal cancer 24.41 10.39 3 291017 8467 70628957
Breast cancer in situ 24.37 10.39 24 290996 887 70636537
Lenticular opacities 24.23 10.39 19 291001 515 70636909
Colitis ulcerative 23.95 10.39 66 290954 33857 70603567
Hypersomnia 23.89 10.39 30 290990 20734 70616690
Heavy menstrual bleeding 23.89 10.39 11 291009 12654 70624770
Delusion 23.86 10.39 26 290994 19139 70618285
Hepatic function abnormal 23.82 10.39 172 290848 67824 70569600
Device occlusion 23.69 10.39 7 291013 10588 70626836
Neuroma 23.67 10.39 14 291006 235 70637189
Benign bone neoplasm 23.66 10.39 8 291012 30 70637394
Second primary malignancy 23.60 10.39 12 291008 13039 70624385
Periarthritis 23.53 10.39 41 290979 2677 70634747
Bone fissure 23.53 10.39 12 291008 148 70637276
Infusion site pain 23.49 10.39 9 291011 11555 70625869
Rheumatoid lung 23.47 10.39 47 290973 3412 70634012
Rash pruritic 23.43 10.39 376 290644 62615 70574809
Kidney transplant rejection 23.36 10.39 6 291014 9955 70627469
Acrochordon 23.35 10.39 24 290996 934 70636490
Haemodynamic instability 23.35 10.39 18 291002 15640 70621784
Tunnel vision 23.31 10.39 27 290993 1204 70636220
Metastases to lung 23.27 10.39 20 291000 16464 70620960
Neoplasm skin 23.21 10.39 28 290992 1304 70636120
Mental impairment 23.09 10.39 22 290998 17233 70620191
Mouth cyst 23.07 10.39 9 291011 55 70637369
Seronegative arthritis 23.04 10.39 46 290974 3333 70634091
Pernicious anaemia 23.00 10.39 19 291001 556 70636868
Odontogenic cyst 22.95 10.39 7 291013 17 70637407
Memory impairment 22.94 10.39 256 290764 92385 70545039
Substance abuse 22.93 10.39 6 291014 9831 70627593
Wound complication 22.87 10.39 53 290967 4256 70633168
Frequent bowel movements 22.87 10.39 32 290988 21121 70616303
Right ventricular failure 22.80 10.39 35 290985 22239 70615185
Hallucination, auditory 22.67 10.39 25 290995 18303 70619121
Salivary gland mass 22.67 10.39 9 291011 58 70637366
Nodule 22.65 10.39 150 290870 19819 70617605
Blood loss anaemia 22.55 10.39 118 290902 14323 70623101
Hormone therapy 22.50 10.39 5 291015 0 70637424
Hepatocellular carcinoma 22.36 10.39 7 291013 10201 70627223
Essential hypertension 22.34 10.39 61 290959 5423 70632001
Nasal polyps 22.29 10.39 54 290966 4462 70632962
Laryngeal ulceration 22.28 10.39 11 291009 126 70637298
Acne 22.17 10.39 43 290977 24946 70612478
Limb injury 22.10 10.39 181 290839 25571 70611853
Chondromalacia 22.07 10.39 12 291008 170 70637254
Palatal disorder 21.99 10.39 17 291003 451 70636973
Hypertensive crisis 21.98 10.39 28 290992 19234 70618190
Embolism 21.95 10.39 13 291007 12975 70624449
Acute pulmonary oedema 21.87 10.39 14 291006 13398 70624026
Progressive multifocal leukoencephalopathy 21.86 10.39 28 290992 19186 70618238
Haemolysis 21.84 10.39 10 291010 11541 70625883
Lymphopenia 21.82 10.39 50 290970 27309 70610115
Post transplant lymphoproliferative disorder 21.77 10.39 8 291012 10537 70626887
Mania 21.72 10.39 23 290997 17151 70620273
Metastases to liver 21.71 10.39 46 290974 25832 70611592
Liver function test increased 21.62 10.39 69 290951 33778 70603646
Otitis media 21.57 10.39 62 290958 5677 70631747
Device malfunction 21.51 10.39 28 290992 19056 70618368
Hyperaesthesia 21.43 10.39 9 291011 10933 70626491
Gastric disorder 21.38 10.39 220 290800 33102 70604322
Gallbladder disorder 21.29 10.39 135 290885 17577 70619847
Thermohypoaesthesia 21.26 10.39 10 291010 102 70637322
Osteosclerosis 21.25 10.39 47 290973 3658 70633766
Fear of injection 21.25 10.39 68 290952 6604 70630820
Urethral caruncle 21.24 10.39 9 291011 70 70637354
Tooth discolouration 21.21 10.39 24 290996 1043 70636381
Influenza like illness 21.11 10.39 169 290851 65162 70572262
Anger 21.09 10.39 21 290999 16111 70621313
Cataract nuclear 20.94 10.39 23 290997 967 70636457
Urticaria 20.91 10.39 509 290511 162540 70474884
Type V hyperlipidaemia 20.90 10.39 23 290997 969 70636455
Hypothyroidism 20.90 10.39 283 290737 45472 70591952
Catatonia 20.89 10.39 4 291016 8129 70629295
Transfusion 20.86 10.39 28 290992 18808 70618616
Circulatory collapse 20.83 10.39 75 290945 35399 70602025
Haemorrhage intracranial 20.82 10.39 44 290976 24733 70612691
Electrolyte imbalance 20.70 10.39 50 290970 26811 70610613
Systemic inflammatory response syndrome 20.68 10.39 9 291011 10703 70626721
Vision blurred 20.65 10.39 270 290750 94714 70542710
Oesophageal ulcer haemorrhage 20.51 10.39 18 291002 573 70636851
Sight disability 20.45 10.39 10 291010 112 70637312
Glucose tolerance impaired 20.45 10.39 68 290952 6738 70630686
Burning sensation 20.38 10.39 130 290890 52740 70584684
BK virus infection 20.37 10.39 4 291016 7985 70629439
Vertigo positional 20.33 10.39 41 290979 2992 70634432
Face injury 20.32 10.39 43 290977 3247 70634177
Conductive deafness 20.30 10.39 9 291011 79 70637345
Musculoskeletal discomfort 20.26 10.39 134 290886 17698 70619726
Multiple-drug resistance 20.25 10.39 3 291017 7352 70630072
Staphylococcal infection 20.23 10.39 132 290888 53272 70584152
Enterococcal infection 20.21 10.39 18 291002 14564 70622860
Photosensitivity reaction 20.18 10.39 30 290990 19310 70618114
Dental prosthesis user 20.16 10.39 7 291013 29 70637395
Dental pulp disorder 20.14 10.39 6 291014 13 70637411
Epicondylitis 20.04 10.39 32 290988 1944 70635480
Lupus-like syndrome 20.03 10.39 97 290923 11418 70626006
Costochondritis 19.96 10.39 34 290986 2180 70635244
Walking aid user 19.90 10.39 75 290945 7906 70629518
Hypernatraemia 19.89 10.39 14 291006 12747 70624677
Therapeutic product effect incomplete 19.86 10.39 359 290661 119523 70517901
Lip neoplasm 19.83 10.39 6 291014 14 70637410
Hypertransaminasaemia 19.83 10.39 6 291014 8937 70628487
White blood cell count increased 19.80 10.39 186 290834 69387 70568037
Pneumonia fungal 19.80 10.39 8 291012 9945 70627479
Ventricular arrhythmia 19.79 10.39 4 291016 7826 70629598
Heart rate decreased 19.78 10.39 161 290859 61854 70575570
Neurosensory hypoacusis 19.75 10.39 12 291008 212 70637212
Bladder pain 19.71 10.39 32 290988 1972 70635452
Musculoskeletal disorder 19.70 10.39 145 290875 19826 70617598
Benign breast neoplasm 19.66 10.39 20 291000 769 70636655
Pseudarthrosis 19.65 10.39 13 291007 268 70637156
Wrong product administered 19.64 10.39 5 291015 8346 70629078
Fibroma 19.61 10.39 19 291001 688 70636736
Hypertonic bladder 19.50 10.39 46 290974 3737 70633687
Osteolysis 19.47 10.39 44 290976 3475 70633949
Suspected suicide 19.46 10.39 6 291014 8828 70628596
Menopause 19.40 10.39 30 290990 1773 70635651
Rectal polyp 19.36 10.39 27 290993 1453 70635971
Respiratory acidosis 19.28 10.39 9 291011 10272 70627152
Stress 19.22 10.39 182 290838 67784 70569640
Acute coronary syndrome 19.20 10.39 33 290987 20046 70617378
Injection site urticaria 19.18 10.39 12 291008 11626 70625798
Peritonitis 19.14 10.39 50 290970 26109 70611315
Cerebral infarction 19.12 10.39 101 290919 42908 70594516
Nephropathy toxic 19.04 10.39 29 290991 18485 70618939
Fibroadenoma of breast 19.03 10.39 13 291007 283 70637141
Erythema 19.02 10.39 649 290371 198914 70438510
Foreign body 19.01 10.39 37 290983 2631 70634793
SARS-CoV-2 test positive 19.00 10.39 6 291014 8695 70628729
Throat tightness 18.95 10.39 47 290973 24975 70612449
Nasal congestion 18.94 10.39 175 290845 65497 70571927
Product storage error 18.92 10.39 19 291001 14522 70622902
Dyspnoea exertional 18.92 10.39 218 290802 78212 70559212
Staphylococcal bacteraemia 18.86 10.39 11 291009 11071 70626353
Myelodysplastic syndrome 18.83 10.39 61 290959 29724 70607700
Petechiae 18.80 10.39 31 290989 19141 70618283
Obesity 18.76 10.39 180 290840 26591 70610833
Hepatitis C 18.75 10.39 15 291005 12792 70624632
Drug dependence 18.70 10.39 84 290936 37237 70600187
Benign neoplasm 18.65 10.39 21 290999 908 70636516
Cushingoid 18.63 10.39 76 290944 8312 70629112
Sputum culture positive 18.63 10.39 42 290978 3312 70634112
Left ventricular dysfunction 18.59 10.39 28 290992 17929 70619495
Parathyroid disorder 18.54 10.39 15 291005 426 70636998
Drug hypersensitivity 18.48 10.39 1282 289738 261177 70376247
Muscle spasticity 18.24 10.39 33 290987 19656 70617768
Toxic encephalopathy 18.18 10.39 10 291010 10396 70627028
Hypoaesthesia oral 18.18 10.39 99 290921 12201 70625223
Device difficult to use 18.14 10.39 11 291009 10838 70626586
Coccydynia 18.13 10.39 28 290992 1653 70635771
Blood creatinine decreased 18.07 10.39 4 291016 7345 70630079
Multiple fractures 18.07 10.39 65 290955 6700 70630724
Injection site warmth 18.07 10.39 18 291002 13807 70623617
Ataxia 18.06 10.39 43 290977 23174 70614250
Oropharyngeal pain 18.04 10.39 282 290738 96028 70541396
Impaired quality of life 18.01 10.39 7 291013 8909 70628515
Uterine cervix atrophy 18.00 10.39 4 291016 0 70637424
Traumatic occlusion 18.00 10.39 4 291016 0 70637424
Multiple sclerosis 17.99 10.39 49 290971 25236 70612188
Ileus 17.99 10.39 46 290974 24191 70613233
Cytomegalovirus viraemia 17.98 10.39 13 291007 11672 70625752
Breath odour 17.95 10.39 27 290993 1557 70635867
Paraesthesia 17.94 10.39 457 290563 145080 70492344
Respiratory disorder 17.88 10.39 91 290929 39032 70598392
Hyperparathyroidism 17.87 10.39 39 290981 3008 70634416
Generalised oedema 17.87 10.39 39 290981 21669 70615755
Vaginal dysplasia 17.85 10.39 6 291014 22 70637402
Hypoalbuminaemia 17.76 10.39 32 290988 19090 70618334
Major depression 17.72 10.39 76 290944 8498 70628926
Pulmonary congestion 17.71 10.39 49 290971 25105 70612319
Antinuclear antibody positive 17.70 10.39 65 290955 6768 70630656
Intestinal perforation 17.62 10.39 24 290996 16020 70621404
Erosive oesophagitis 17.59 10.39 36 290984 2655 70634769
Haemolytic anaemia 17.57 10.39 26 290994 16768 70620656
Leukoplakia oral 17.54 10.39 12 291008 262 70637162
Skin haemorrhage 17.48 10.39 10 291010 10170 70627254
Bone atrophy 17.44 10.39 6 291014 24 70637400
Hepatomegaly 17.42 10.39 28 290992 17464 70619960
Cervical spinal stenosis 17.40 10.39 31 290989 2060 70635364
Osteodystrophy 17.39 10.39 5 291015 9 70637415
Tympanosclerosis 17.39 10.39 5 291015 9 70637415
Grief reaction 17.38 10.39 12 291008 266 70637158
Apathy 17.36 10.39 14 291006 11894 70625530
Red blood cell sedimentation rate abnormal 17.31 10.39 33 290987 19270 70618154
Periostitis 17.30 10.39 16 291004 546 70636878
Bone pain 17.30 10.39 299 290721 50523 70586901
Hyperparathyroidism primary 17.26 10.39 14 291006 399 70637025
Iodine allergy 17.25 10.39 16 291004 548 70636876
Tooth dislocation 17.25 10.39 6 291014 25 70637399
Hyperkeratosis 17.19 10.39 66 290954 7018 70630406
Polyneuropathy 17.19 10.39 39 290981 21376 70616048
Coagulopathy 17.16 10.39 74 290946 33175 70604249
Autoimmune disorder 17.15 10.39 76 290944 8620 70628804
Taste disorder 17.09 10.39 13 291007 11372 70626052
Chronic kidney disease 17.05 10.39 164 290856 60893 70576531
Gastrooesophageal cancer 17.05 10.39 5 291015 10 70637414
Nervous system disorder 17.03 10.39 47 290973 24099 70613325
Mobility decreased 17.02 10.39 548 290472 102451 70534973
Rhinorrhoea 16.99 10.39 182 290838 66189 70571235
Head discomfort 16.97 10.39 17 291003 13006 70624418
Staphylococcal sepsis 16.96 10.39 18 291002 13409 70624015
Hypocalcaemia 16.93 10.39 111 290909 44748 70592676
Dermatitis exfoliative generalised 16.80 10.39 3 291017 6411 70631013
Pharyngeal oedema 16.71 10.39 24 290996 15672 70621752
Emotional distress 16.71 10.39 87 290933 37101 70600323
Spondylitis 16.71 10.39 41 290979 3416 70634008
Crying 16.70 10.39 39 290981 21160 70616264
Cardiomyopathy 16.68 10.39 54 290966 26319 70611105
Oesophagitis chemical 16.68 10.39 7 291013 53 70637371
Presbyopia 16.64 10.39 16 291004 574 70636850
Peripheral coldness 16.63 10.39 21 290999 14479 70622945
Amenorrhoea 16.59 10.39 4 291016 6926 70630498
Face oedema 16.56 10.39 52 290968 25587 70611837
C-reactive protein abnormal 16.56 10.39 236 290784 38343 70599081
Metatarsalgia 16.53 10.39 11 291009 229 70637195
Dermatitis acneiform 16.52 10.39 8 291012 8937 70628487
Therapeutic response unexpected 16.50 10.39 31 290989 18200 70619224
Blood albumin decreased 16.42 10.39 42 290978 22085 70615339
Bladder prolapse 16.40 10.39 23 290997 1244 70636180
Sudden death 16.40 10.39 39 290981 21025 70616399
Cardiac failure chronic 16.36 10.39 11 291009 10258 70627166
Radicular pain 16.28 10.39 13 291007 362 70637062
Clonus 16.27 10.39 3 291017 6265 70631159
Aplasia pure red cell 16.26 10.39 5 291015 7369 70630055
Tubulointerstitial nephritis 16.24 10.39 75 290945 33001 70604423
Amino acid level increased 16.22 10.39 17 291003 677 70636747
Deafness 16.20 10.39 135 290885 19168 70618256
Brain injury 16.09 10.39 12 291008 10605 70626819
Muscle twitching 16.01 10.39 36 290984 19791 70617633
Uterine polyp 16.00 10.39 24 290996 1381 70636043
Affect lability 15.99 10.39 11 291009 10135 70627289
Eye pruritus 15.99 10.39 22 290998 14625 70622799
Skin burning sensation 15.96 10.39 14 291006 11412 70626012
Bladder cancer 15.89 10.39 29 290991 17213 70620211
Anhedonia 15.87 10.39 21 290999 14192 70623232
Post laminectomy syndrome 15.87 10.39 12 291008 308 70637116
Allergy to chemicals 15.86 10.39 29 290991 1967 70635457
Renal cancer 15.83 10.39 15 291005 11781 70625643
Knee deformity 15.82 10.39 20 291000 978 70636446
Drug level below therapeutic 15.81 10.39 8 291012 8715 70628709
Tongue geographic 15.74 10.39 7 291013 62 70637362
Bone abscess 15.73 10.39 14 291006 454 70636970
Oral discharge 15.73 10.39 11 291009 249 70637175
Tympanic membrane perforation 15.73 10.39 25 290995 1513 70635911
Intestinal obstruction 15.72 10.39 94 290926 38731 70598693
Partial seizures 15.67 10.39 7 291013 8198 70629226
Pulmonary fibrosis 15.58 10.39 212 290808 34098 70603326
Sinus polyp 15.58 10.39 14 291006 460 70636964
Jaundice 15.56 10.39 131 290889 49977 70587447
Atrial flutter 15.53 10.39 38 290982 20289 70617135
Cerebral small vessel ischaemic disease 15.53 10.39 20 291000 996 70636428
Abortion induced 15.52 10.39 4 291016 6621 70630803
Arteriosclerosis 15.40 10.39 119 290901 16519 70620905
Influenza 15.39 10.39 352 290668 113348 70524076
Cystitis haemorrhagic 15.39 10.39 8 291012 8585 70628839
Heparin-induced thrombocytopenia 15.34 10.39 9 291011 9028 70628396
Nerve degeneration 15.32 10.39 11 291009 260 70637164
Blood pressure abnormal 15.29 10.39 25 290995 15489 70621935
Hepatitis acute 15.21 10.39 21 290999 13941 70623483
Delirium 15.17 10.39 215 290805 74399 70563025
Haematemesis 15.16 10.39 283 290737 48514 70588910
Avulsion fracture 15.14 10.39 11 291009 265 70637159
Prothrombin time prolonged 15.12 10.39 27 290993 16163 70621261
Vascular device infection 15.11 10.39 7 291013 8023 70629401
Gastric ulcer 15.09 10.39 198 290822 31592 70605832
Abdominal pain upper 15.05 10.39 645 290375 192957 70444467
Mandibular mass 15.04 10.39 10 291010 208 70637216
Activated partial thromboplastin time prolonged 15.03 10.39 20 291000 13485 70623939
Blood calcium decreased 15.01 10.39 64 290956 28782 70608642
Nystagmus 14.94 10.39 10 291010 9345 70628079
Pharyngeal swelling 14.92 10.39 4 291016 6449 70630975
Oesophageal injury 14.92 10.39 7 291013 71 70637353
Skin plaque 14.90 10.39 11 291009 9772 70627652
Pneumatosis intestinalis 14.90 10.39 3 291017 5884 70631540
Bone erosion 14.88 10.39 110 290910 15063 70622361
Bone cyst 14.87 10.39 35 290985 2839 70634585
Incision site cellulitis 14.86 10.39 8 291012 111 70637313
Parkinsonism 14.82 10.39 25 290995 15300 70622124
Ilium fracture 14.79 10.39 10 291010 214 70637210
Expired product administered 14.78 10.39 4 291016 6409 70631015
Breast necrosis 14.75 10.39 7 291013 73 70637351
Gastrointestinal haemorrhage 14.74 10.39 440 290580 136968 70500456
Bronchopulmonary aspergillosis 14.72 10.39 41 290979 20961 70616463
Scapula fracture 14.62 10.39 16 291004 670 70636754
Blood potassium increased 14.61 10.39 60 290960 27266 70610158
Throat irritation 14.55 10.39 85 290935 35219 70602205
Meniere's disease 14.47 10.39 9 291011 166 70637258
Vascular headache 14.46 10.39 6 291014 44 70637380
Peritonitis bacterial 14.42 10.39 10 291010 9174 70628250
Normal newborn 14.39 10.39 4 291016 6296 70631128
Hypersensitivity vasculitis 14.38 10.39 5 291015 6817 70630607
Fibrous dysplasia of bone 14.36 10.39 4 291016 6 70637418
Central nervous system lesion 14.32 10.39 18 291002 12435 70624989
Pulmonary hypertension 14.30 10.39 122 290898 46414 70591010
Hypovolaemic shock 14.29 10.39 14 291006 10823 70626601
Leukoencephalopathy 14.29 10.39 6 291014 7288 70630136
Actinic elastosis 14.23 10.39 6 291014 46 70637378
Epstein-Barr virus infection 14.23 10.39 20 291000 13178 70624246
Mixed liver injury 14.21 10.39 4 291016 6245 70631179
Ketoacidosis 14.20 10.39 6 291014 7263 70630161
Vaginal prolapse 14.19 10.39 11 291009 293 70637131
Product dispensing error 14.18 10.39 17 291003 11991 70625433
Breast neoplasm 14.17 10.39 18 291002 884 70636540
Hospice care 14.17 10.39 8 291012 8197 70629227
Hepatic necrosis 14.13 10.39 9 291011 8637 70628787
Poliomyelitis 14.12 10.39 6 291014 47 70637377
Labile hypertension 14.07 10.39 14 291006 524 70636900
Vaginal haemorrhage 14.07 10.39 40 290980 20312 70617112
Parathyroid tumour benign 14.04 10.39 16 291004 701 70636723
Impaired fasting glucose 13.99 10.39 12 291008 370 70637054
Osteorrhagia 13.98 10.39 4 291016 7 70637417
Mastoid disorder 13.98 10.39 5 291015 23 70637401
Seasonal allergy 13.94 10.39 99 290921 13385 70624039
Osteocalcin decreased 13.91 10.39 6 291014 49 70637375
Ear congestion 13.90 10.39 30 290990 2297 70635127
Coma scale abnormal 13.89 10.39 8 291012 8108 70629316
Stress cardiomyopathy 13.88 10.39 12 291008 9850 70627574
Polyuria 13.79 10.39 21 290999 13385 70624039
Bursa disorder 13.76 10.39 10 291010 241 70637183
Drug level decreased 13.74 10.39 19 291001 12605 70624819
Renal tubular disorder 13.73 10.39 4 291016 6106 70631318
Glycosylated haemoglobin increased 13.70 10.39 32 290988 17359 70620065
Cold sweat 13.65 10.39 31 290989 16985 70620439
Persistent depressive disorder 13.63 10.39 19 291001 1022 70636402
Atelectasis 13.58 10.39 180 290840 28782 70608642
Abdominal abscess 13.56 10.39 5 291015 6573 70630851
Clavicle fracture 13.55 10.39 41 290979 3863 70633561
Cerebrovascular disorder 13.55 10.39 39 290981 3574 70633850
Erythroplasia 13.50 10.39 3 291017 0 70637424
External fixation of fracture 13.50 10.39 3 291017 0 70637424
Lipoma of breast 13.50 10.39 3 291017 0 70637424
Bartholin's cyst 13.50 10.39 3 291017 0 70637424
Deafness traumatic 13.50 10.39 3 291017 0 70637424
Resorption bone decreased 13.50 10.39 3 291017 0 70637424
Intestinal mucosal tear 13.50 10.39 3 291017 0 70637424
Dermatitis exfoliative 13.49 10.39 14 291006 10537 70626887
Lip neoplasm malignant stage unspecified 13.49 10.39 5 291015 26 70637398
Urinary retention 13.45 10.39 144 290876 52376 70585048
Post procedural constipation 13.41 10.39 6 291014 54 70637370
Pyogenic granuloma 13.39 10.39 13 291007 472 70636952
Euglycaemic diabetic ketoacidosis 13.37 10.39 4 291016 6003 70631421
Bradypnoea 13.37 10.39 3 291017 5456 70631968
Stupor 13.33 10.39 5 291015 6504 70630920
Pulseless electrical activity 13.30 10.39 21 290999 13194 70624230
Intestinal ischaemia 13.29 10.39 18 291002 12046 70625378
Blood alkaline phosphatase increased 13.22 10.39 165 290855 58356 70579068
Cutis laxa 13.18 10.39 8 291012 141 70637283
Candida infection 13.16 10.39 85 290935 34388 70603036
Dermatitis bullous 13.10 10.39 20 291000 12737 70624687
Pulmonary thrombosis 13.10 10.39 16 291004 11192 70626232
Transplant dysfunction 13.03 10.39 6 291014 6903 70630521
Cyanosis 13.01 10.39 50 290970 23156 70614268
Euphoric mood 12.97 10.39 6 291014 6883 70630541
Coronary arterial stent insertion 12.96 10.39 4 291016 5883 70631541
Lacunar infarction 12.96 10.39 52 290968 5644 70631780
Restrictive pulmonary disease 12.94 10.39 29 290991 2277 70635147
Complication of device insertion 12.92 10.39 3 291017 5329 70632095
Drug abuser 12.88 10.39 4 291016 5860 70631564
Eustachian tube disorder 12.86 10.39 6 291014 60 70637364
Carcinoid tumour pulmonary 12.81 10.39 11 291009 340 70637084
Hypoxic-ischaemic encephalopathy 12.80 10.39 7 291013 7301 70630123
Macular degeneration 12.80 10.39 63 290957 7465 70629959
Tongue ulceration 12.78 10.39 39 290981 3692 70633732
Wound secretion 12.77 10.39 51 290969 5524 70631900
Bone callus excessive 12.76 10.39 5 291015 31 70637393
Genital haemorrhage 12.72 10.39 4 291016 5811 70631613
Weight increased 12.69 10.39 1157 289863 241174 70396250
Blood potassium decreased 12.68 10.39 112 290908 42309 70595115
Small intestinal obstruction 12.65 10.39 55 290965 24600 70612824
Serum ferritin increased 12.62 10.39 11 291009 8994 70628430
Loss of personal independence in daily activities 12.57 10.39 446 290574 84464 70552960
Amylase increased 12.54 10.39 14 291006 10194 70627230
Influenza B virus test positive 12.54 10.39 11 291009 350 70637074
Labyrinthitis 12.54 10.39 32 290988 2732 70634692
Neutrophilia 12.53 10.39 7 291013 7214 70630210
Drug specific antibody present 12.52 10.39 4 291016 5754 70631670
Immunodeficiency 12.51 10.39 34 290986 17521 70619903
Parophthalmia 12.48 10.39 11 291009 352 70637072
Device related infection 12.47 10.39 79 290941 32106 70605318
Osteoporotic fracture 12.45 10.39 39 290981 3745 70633679
Speech disorder 12.43 10.39 140 290880 50440 70586984
Intraocular lens implant 12.41 10.39 11 291009 355 70637069
Therapy change 12.39 10.39 6 291014 6703 70630721
Encephalitis 12.38 10.39 23 290997 13562 70623862
Pulse absent 12.36 10.39 12 291008 9318 70628106
Subdural haematoma 12.36 10.39 70 290950 29228 70608196
Needle issue 12.32 10.39 16 291004 10899 70626525
Electrocardiogram ST segment elevation 12.31 10.39 8 291012 7596 70629828
Oesophageal irritation 12.30 10.39 7 291013 109 70637315
Grip strength decreased 12.27 10.39 108 290912 15577 70621847
Ammonia increased 12.27 10.39 7 291013 7131 70630293
Numb chin syndrome 12.27 10.39 4 291016 13 70637411
Lipoma 12.26 10.39 32 290988 2770 70634654
Hepatic cancer 12.21 10.39 13 291007 9670 70627754
Psychiatric symptom 12.18 10.39 6 291014 6638 70630786
Wall motion score index abnormal 12.13 10.39 7 291013 112 70637312
Escherichia infection 12.11 10.39 31 290989 16300 70621124
Incorrect product administration duration 12.08 10.39 16 291004 10808 70626616
Dysplastic naevus syndrome 12.04 10.39 4 291016 14 70637410
Nail operation 12.00 10.39 13 291007 538 70636886
Atrioventricular block 12.00 10.39 21 290999 12667 70624757
Performance status decreased 11.99 10.39 4 291016 5597 70631827
Central nervous system mass 11.97 10.39 7 291013 115 70637309
Hereditary angioedema 11.96 10.39 3 291017 5056 70632368
Peripheral ischaemia 11.91 10.39 11 291009 8747 70628677
Hepatitis cholestatic 11.90 10.39 21 290999 12629 70624795
Oesophagitis haemorrhagic 11.90 10.39 14 291006 635 70636789
Injection site extravasation 11.88 10.39 11 291009 8735 70628689
Clostridium difficile colitis 11.85 10.39 70 290950 28926 70608498
Jaw clicking 11.83 10.39 4 291016 15 70637409
Pelvic floor muscle weakness 11.83 10.39 4 291016 15 70637409
Pulmonary tuberculosis 11.72 10.39 9 291011 7836 70629588
Rash papular 11.72 10.39 37 290983 18173 70619251
Portal hypertension 11.69 10.39 6 291014 6486 70630938
Tooth erosion 11.66 10.39 11 291009 385 70637039
Soft tissue inflammation 11.64 10.39 10 291010 309 70637115
Erythema marginatum 11.63 10.39 4 291016 16 70637408
Callus formation delayed 11.63 10.39 4 291016 16 70637408
Gastrointestinal tract adenoma 11.59 10.39 12 291008 471 70636953
Hiccups 11.58 10.39 12 291008 9040 70628384
Vitreous detachment 11.56 10.39 26 290994 2047 70635377
Protein urine present 11.54 10.39 13 291007 9427 70627997
Skin cancer 11.54 10.39 95 290925 13441 70623983
Giant cell arteritis 11.51 10.39 29 290991 2456 70634968
Rhinitis 11.48 10.39 84 290936 11463 70625961
Appendicitis 11.48 10.39 33 290987 16700 70620724
Weight bearing difficulty 11.47 10.39 32 290988 2880 70634544
Joint ankylosis 11.47 10.39 22 290998 1547 70635877
Crepitations 11.47 10.39 68 290952 8646 70628778
Enteritis 11.45 10.39 22 290998 12809 70624615
Osteoarthropathy 11.43 10.39 3 291017 3 70637421
Reaction to food additive 11.43 10.39 3 291017 3 70637421
Complications of transplanted kidney 11.43 10.39 5 291015 5929 70631495
Macrognathia 11.43 10.39 3 291017 3 70637421
Vulva cyst 11.43 10.39 3 291017 3 70637421
Metastases to bone 11.43 10.39 50 290970 22326 70615098
Dry mouth 11.42 10.39 374 290646 70083 70567341
Paralysis 11.40 10.39 20 291000 12052 70625372
Retching 11.35 10.39 31 290989 15948 70621476
Sinus bradycardia 11.34 10.39 54 290966 23569 70613855
Bronchopulmonary aspergillosis allergic 11.32 10.39 25 290995 1944 70635480
Breast hyperplasia 11.31 10.39 7 291013 128 70637296
Oesophageal perforation 11.28 10.39 20 291000 1324 70636100
Interstitial lung disease 11.28 10.39 335 290685 104350 70533074
Dystrophic calcification 11.26 10.39 7 291013 129 70637295
Dysstasia 11.26 10.39 59 290961 25120 70612304
Skin fissures 11.26 10.39 18 291002 11252 70626172
Human herpesvirus 6 infection 11.26 10.39 3 291017 4856 70632568
Dental cyst 11.26 10.39 4 291016 18 70637406
Anxiety 11.24 10.39 1050 289970 219280 70418144
Cubital tunnel syndrome 11.19 10.39 10 291010 326 70637098
Blood magnesium decreased 11.14 10.39 28 290992 14813 70622611
Acidosis 11.13 10.39 38 290982 18225 70619199
Blood phosphorus increased 11.13 10.39 7 291013 6763 70630661
Calcinosis 11.13 10.39 26 290994 2099 70635325
Hypereosinophilic syndrome 11.11 10.39 12 291008 495 70636929
Personality change 11.08 10.39 12 291008 8858 70628566
Blood 25-hydroxycholecalciferol decreased 11.07 10.39 10 291010 331 70637093
Metabolic disorder 11.05 10.39 10 291010 8030 70629394
Splenomegaly 11.01 10.39 40 290980 18830 70618594
Gingivitis ulcerative 10.99 10.39 9 291011 260 70637164
Cytomegalovirus chorioretinitis 10.97 10.39 4 291016 5294 70632130
Congenital bowing of long bones 10.92 10.39 4 291016 20 70637404
Salivary gland adenoma 10.92 10.39 4 291016 20 70637404
Hallucination, visual 10.87 10.39 73 290947 29264 70608160
Electroencephalogram abnormal 10.83 10.39 4 291016 5254 70632170
Pleuritic pain 10.81 10.39 68 290952 8829 70628595
Injection site induration 10.81 10.39 13 291007 9155 70628269
Uterovaginal prolapse 10.80 10.39 5 291015 49 70637375
Injection site rash 10.80 10.39 33 290987 16377 70621047
Stomatitis necrotising 10.79 10.39 8 291012 199 70637225
Anal abscess 10.79 10.39 11 291009 8347 70629077
Red blood cells urine positive 10.73 10.39 3 291017 4706 70632718
Laboratory test abnormal 10.73 10.39 62 290958 25761 70611663
Bradykinesia 10.72 10.39 9 291011 7493 70629931
Breast cancer stage III 10.71 10.39 55 290965 6626 70630798
Poor personal hygiene 10.71 10.39 12 291008 516 70636908
Enchondromatosis 10.63 10.39 5 291015 51 70637373
Bladder diverticulum 10.62 10.39 6 291014 92 70637332
Intervertebral disc displacement 10.60 10.39 11 291009 433 70636991
Ganglioneuroma 10.59 10.39 7 291013 144 70637280
Repetitive strain injury 10.59 10.39 7 291013 144 70637280
Uterine stenosis 10.58 10.39 3 291017 5 70637419
Hepatitis fulminant 10.55 10.39 7 291013 6574 70630850
Abnormal dreams 10.53 10.39 17 291003 10586 70626838
Obstructive airways disorder 10.52 10.39 158 290862 25955 70611469
Pharyngitis streptococcal 10.51 10.39 14 291006 9434 70627990
Complications of bone marrow transplant 10.49 10.39 13 291007 623 70636801
Abdominal bruit 10.46 10.39 4 291016 23 70637401
Debridement 10.45 10.39 22 290998 1655 70635769
Oesophagitis ulcerative 10.42 10.39 16 291004 940 70636484
Orthopnoea 10.40 10.39 14 291006 9394 70628030

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M05BA04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates
ATC M05BB03 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB05 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB06 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
FDA CS M0006519 Diphosphonates
FDA EPC N0000175579 Bisphosphonate
CHEBI has role CHEBI:50643 dimethylallyltranstransferase inhibitors
CHEBI has role CHEBI:50646 antiosteoporotic
MeSH PA D050071 Bone Density Conservation Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteitis deformans indication 2089002 DOID:5408
Postmenopausal osteoporosis indication 102447009
Hypogonadal Osteoporosis in Males indication
Prevention of Glucocorticoid-Induced Osteoporosis indication
Glucocorticoid Induced Osteoporosis indication
Complex regional pain syndrome off-label use 128200000 DOID:3223
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Esophagitis contraindication 16761005 DOID:11963
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Ulcer of esophagus contraindication 30811009
Sarcoidosis contraindication 31541009 DOID:11335
Vitamin D deficiency contraindication 34713006
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Atrial fibrillation contraindication 49436004 DOID:0060224
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Stricture of esophagus contraindication 63305008
Hypercalcemia contraindication 66931009 DOID:12678
Fracture of femur contraindication 71620000
Duodenitis contraindication 72007001 DOID:8643
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Bed-ridden contraindication 160685001
Acute peptic ulcer contraindication 196682000
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Aseptic necrosis of bone of jaw contraindication 441809006
High Grade Dysplasia associated with Barrett's Esophagus contraindication
Esophageal Obstruction contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.27 acidic
pKa2 5.34 acidic
pKa3 6.32 acidic
pKa4 10.39 acidic
pKa5 12.82 acidic
pKa6 10.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Farnesyl pyrophosphate synthase Enzyme INHIBITOR Ki 7.35 CHEMBL CHEMBL
Protein farnesyltransferase subunit beta Enzyme IC50 7.30 WOMBAT-PK
Farnesyl pyrophosphate synthase Enzyme Ki 7.02 CHEMBL
Farnesyl pyrophosphate synthase Enzyme IC50 5.77 CHEMBL
Isopentenyl-diphosphate Delta-isomerase 1 Enzyme IC50 5.77 CHEMBL
Farnesyl pyrophosphate synthase Enzyme IC50 4.82 CHEMBL
Farnesyl pyrophosphate synthase, EC 2.5.1.1, EC 2.5.1.10 Unclassified Ki 7.04 CHEMBL

External reference:

IDSource
4020932 VUID
N0000148414 NUI
D00939 KEGG_DRUG
121268-17-5 SECONDARY_CAS_RN
203152 RXNORM
C0771311 UMLSCUI
CHEBI:2567 CHEBI
212 PDB_CHEM_ID
CHEMBL870 ChEMBL_ID
CHEMBL675 ChEMBL_ID
DB00630 DRUGBANK_ID
2088 PUBCHEM_CID
3141 IUPHAR_LIGAND_ID
6462 INN_ID
X1J18R4W8P UNII
005056 NDDF
005057 NDDF
D019386 MESH_DESCRIPTOR_UI
1217581008 SNOMEDCT_US
391729003 SNOMEDCT_US
391730008 SNOMEDCT_US
421552005 SNOMEDCT_US
96290008 SNOMEDCT_US
4020932 VANDF
131536 MMSL
4146 MMSL
d03849 MMSL

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FOSAMAX HUMAN PRESCRIPTION DRUG LABEL 1 0006-0031 TABLET 70 mg ORAL NDA 28 sections
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0270 TABLET 70 mg ORAL NDA 27 sections
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0710 TABLET 70 mg ORAL NDA 27 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-0282 SOLUTION 70 mg ORAL ANDA 28 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1676 TABLET 5 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1678 TABLET 10 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1679 TABLET 35 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1680 TABLET 40 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1681 TABLET 70 mg ORAL ANDA 29 sections
Binosto HUMAN PRESCRIPTION DRUG LABEL 1 0178-0101 TABLET, EFFERVESCENT 70 mg ORAL NDA 20 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-696 TABLET 35 mg ORAL ANDA 27 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-697 TABLET 70 mg ORAL ANDA 27 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-718 TABLET 35 mg ORAL ANDA 29 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-718 TABLET 35 mg ORAL ANDA 29 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-719 TABLET 70 mg ORAL ANDA 29 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-719 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-631 TABLET 10 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-631 TABLET 10 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-632 TABLET 35 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-632 TABLET 35 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-633 TABLET 70 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-633 TABLET 70 mg ORAL ANDA 27 sections
Binosto HUMAN PRESCRIPTION DRUG LABEL 1 17139-400 TABLET, EFFERVESCENT 70 mg ORAL NDA 21 sections
Binosto HUMAN PRESCRIPTION DRUG LABEL 1 17139-400 TABLET, EFFERVESCENT 70 mg ORAL NDA 21 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-901 TABLET 35 mg ORAL ANDA 27 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-902 TABLET 70 mg ORAL ANDA 27 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-554 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-820 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-993 TABLET 35 mg ORAL ANDA 29 sections
alendronate sodium HUMAN PRESCRIPTION DRUG LABEL 1 50090-1091 TABLET 35 mg ORAL ANDA 27 sections