alendronic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
calcium metabolism regulator, pharmaceutical aid 112 66376-36-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alendronate monosodium salt trihydrate
  • alendronate sodium trihydrate
  • alendronate sodium hydrate
  • alendronate
  • alendronic acid
  • alendronate sodium
  • aminohydroxybutane bisphosphonate
  • MK-217
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
  • Molecular weight: 249.10
  • Formula: C4H13NO7P2
  • CLOGP: -3.79
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 6
  • TPSA: 161.31
  • ALOGS: -1.17
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg O
10 mg O
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 45 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.68 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 0.70 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.33 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.22 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.10 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT1,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAP3K3,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK7,MAPK9,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 61
kinase-selectivity-class AURKA,AXL,BMX,CDK2,CDK4,CDK9,CHUK,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,IKBKB,JAK2,MAP2K6,MAP3K14,MAP3K2,MAPK7,MAPK8,PIK3CD,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70 26
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Sept. 29, 1995 FDA MERCK AND CO INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Femur fracture 6080.27 10.67 3941 661934 42141 89920431
Low turnover osteopathy 2962.10 10.67 1129 664746 3089 89959483
Pemphigus 2631.04 10.67 6740 659135 320124 89642448
Osteonecrosis 2426.92 10.67 1805 664070 24436 89938136
Systemic lupus erythematosus 2379.23 10.67 6928 658947 354968 89607604
Glossodynia 2329.97 10.67 6380 659495 315399 89647173
Osteonecrosis of jaw 2170.25 10.67 2000 663875 37103 89925469
Intramedullary rod insertion 2111.65 10.67 739 665136 1433 89961139
Hand deformity 1848.63 10.67 5571 660304 290791 89671781
Wound 1611.80 10.67 5392 660483 297588 89664984
Arthropathy 1601.08 10.67 6111 659764 360131 89602441
Abdominal discomfort 1493.44 10.67 7196 658679 470132 89492440
Atypical femur fracture 1416.62 10.67 766 665109 5655 89956917
Toxicity to various agents 1413.39 10.67 214 665661 287632 89674940
Pericarditis 1386.30 10.67 4751 661124 265400 89697172
Stress fracture 1362.45 10.67 827 665048 7784 89954788
Alopecia 1324.21 10.67 7143 658732 487928 89474644
Anti-cyclic citrullinated peptide antibody positive 1288.89 10.67 4244 661631 232189 89730383
Impaired healing 1223.37 10.67 4144 661731 230055 89732517
Duodenal ulcer perforation 1125.37 10.67 3881 661994 217407 89745165
Fracture nonunion 1124.95 10.67 474 665401 1818 89960754
Swelling 1090.44 10.67 6003 659872 413055 89549517
Synovitis 1085.59 10.67 5048 660827 324704 89637868
Helicobacter infection 1074.00 10.67 3886 661989 222964 89739608
Death 1073.80 10.67 1063 664812 455488 89507084
Osteoarthritis 1069.58 10.67 3517 662358 192213 89770359
Product dose omission issue 1010.26 10.67 439 665436 291248 89671324
Discomfort 1003.62 10.67 4334 661541 270001 89692571
Nausea 970.64 10.67 4534 661341 1105782 88856790
Open reduction of fracture 969.49 10.67 353 665522 809 89961763
Contraindicated product administered 944.85 10.67 4750 661125 315389 89647183
Neutropenia 933.67 10.67 249 665626 224655 89737917
Acute kidney injury 909.08 10.67 620 665255 319767 89642805
Anaemia postoperative 875.12 10.67 393 665482 1820 89960752
Completed suicide 860.54 10.67 51 665824 145007 89817565
Dental caries 834.50 10.67 683 665192 10714 89951858
Febrile neutropenia 818.89 10.67 100 665775 158249 89804323
Drug interaction 805.75 10.67 519 665356 275934 89686638
Osteomyelitis 780.71 10.67 993 664882 26853 89935719
Blood cholesterol increased 779.38 10.67 3311 662564 204701 89757871
Off label use 738.76 10.67 4911 660964 1097341 88865231
Folliculitis 737.32 10.67 3216 662659 201137 89761435
Rheumatoid factor positive 722.77 10.67 2833 663042 168817 89793755
Irritable bowel syndrome 716.91 10.67 3223 662652 204225 89758347
Disease progression 708.18 10.67 144 665731 156471 89806101
COVID-19 706.24 10.67 184 665691 168659 89793913
Infusion related reaction 698.44 10.67 5345 660530 411435 89551137
Hypotension 689.84 10.67 825 665050 324572 89638000
Hepatic enzyme increased 679.71 10.67 4758 661117 355978 89606594
Hyperlipidaemia 661.17 10.67 829 665046 22087 89940485
Diarrhoea 656.33 10.67 4130 661745 935060 89027512
Type 2 diabetes mellitus 653.68 10.67 3092 662783 200152 89762420
Rheumatic fever 646.04 10.67 2529 663346 150592 89811980
Muscle injury 643.18 10.67 2788 663087 173866 89788706
Intentional overdose 598.96 10.67 20 665855 93814 89868758
Tooth disorder 591.88 10.67 921 664954 30169 89932403
Jaw disorder 583.50 10.67 413 665462 5146 89957426
Hypercholesterolaemia 578.65 10.67 1844 664031 99048 89863524
Blister 555.91 10.67 3489 662386 251509 89711063
Thrombocytopenia 543.84 10.67 441 665434 208284 89754288
Oral infection 526.01 10.67 380 665495 4900 89957672
Bursitis 514.14 10.67 2123 663752 129531 89833041
Malignant neoplasm progression 509.38 10.67 86 665789 106784 89855788
Injection site pain 508.73 10.67 324 665551 173375 89789197
Drug abuse 503.83 10.67 24 665851 82323 89880249
Spinal osteoarthritis 501.06 10.67 660 665215 18488 89944084
Maternal exposure during pregnancy 497.09 10.67 4421 661454 355642 89606930
Psoriatic arthropathy 480.14 10.67 3096 662779 225239 89737333
Swollen joint count increased 472.38 10.67 1841 664034 109365 89853207
White blood cell count decreased 460.89 10.67 333 665542 166776 89795796
Cough 453.32 10.67 1305 664570 367657 89594915
Sleep disorder due to general medical condition, insomnia type 446.16 10.67 2002 663873 126692 89835880
Liver injury 443.37 10.67 2445 663430 168122 89794450
Hyperhidrosis 442.47 10.67 224 665651 136081 89826491
Vomiting 439.83 10.67 3694 662181 784599 89177973
Suicide attempt 439.64 10.67 29 665846 75370 89887202
Fracture delayed union 428.41 10.67 253 665622 2253 89960319
Bone disorder 423.59 10.67 673 665202 22447 89940125
Exostosis of jaw 422.80 10.67 200 665675 1067 89961505
Fibromyalgia 416.05 10.67 2768 663107 203501 89759071
Adverse event 412.58 10.67 1834 664041 115584 89846988
Sepsis 405.72 10.67 433 665442 179381 89783191
Platelet count decreased 404.46 10.67 253 665622 136716 89825856
Somnolence 397.83 10.67 574 665301 208510 89754062
Temporomandibular joint syndrome 395.38 10.67 287 665588 3730 89958842
Foot fracture 393.72 10.67 704 665171 25902 89936670
Injury 393.01 10.67 2640 663235 194709 89767863
Seizure 386.99 10.67 331 665544 152298 89810274
Osteopenia 386.71 10.67 644 665231 22358 89940214
Intervertebral disc degeneration 386.50 10.67 552 665323 16722 89945850
Anaemia 384.59 10.67 1317 664558 351485 89611087
Hip arthroplasty 381.86 10.67 1331 664544 74877 89887695
Gastrooesophageal reflux disease 381.14 10.67 2306 663569 164031 89798541
Therapeutic product effect decreased 377.58 10.67 3398 662477 274173 89688399
Drug intolerance 376.89 10.67 4979 660896 442612 89519960
Vitamin D deficiency 376.73 10.67 550 665325 17006 89945566
Tooth fracture 376.58 10.67 464 665411 12136 89950436
Cardiac arrest 374.09 10.67 151 665724 104784 89857788
Hypersensitivity 372.59 10.67 5033 660842 449644 89512928
Feeling abnormal 365.94 10.67 413 665462 166822 89795750
Ill-defined disorder 364.93 10.67 2468 663407 182423 89780149
Device failure 361.75 10.67 342 665533 6555 89956017
Medical device removal 356.74 10.67 181 665694 1152 89961420
Pancytopenia 353.90 10.67 223 665652 120040 89842532
Product use issue 349.80 10.67 3835 662040 326084 89636488
Facet joint syndrome 348.06 10.67 1540 664335 96849 89865723
Knee arthroplasty 346.65 10.67 1369 664506 81813 89880759
Drug ineffective 344.51 10.67 7658 658217 1376640 88585932
Abortion spontaneous 339.83 10.67 13 665862 54043 89908529
Tremor 336.52 10.67 377 665498 152796 89809776
Headache 336.40 10.67 4397 661478 858349 89104223
Pathological fracture 328.63 10.67 380 665495 9280 89953292
Joint swelling 326.26 10.67 5351 660524 497949 89464623
Gingival disorder 325.90 10.67 255 665620 3736 89958836
Myelosuppression 320.32 10.67 18 665857 53573 89908999
Periodontal disease 319.58 10.67 183 665692 1529 89961043
Joint range of motion decreased 315.48 10.67 1888 663987 133755 89828817
Dehydration 314.76 10.67 593 665282 193854 89768718
Dyspnoea 310.85 10.67 4581 661294 876374 89086198
Electrocardiogram QT prolonged 302.79 10.67 79 665796 72377 89890195
Hypertension 301.12 10.67 4877 660998 452655 89509917
Illness 300.35 10.67 113 665762 81856 89880716
Neutrophil count decreased 298.91 10.67 78 665797 71454 89891118
Exostosis 298.04 10.67 964 664911 52170 89910402
Drug ineffective for unapproved indication 293.53 10.67 65 665810 66579 89895993
Lower respiratory tract infection 289.57 10.67 2965 662910 247694 89714878
Injection site erythema 289.33 10.67 183 665692 98319 89864253
Constipation 286.64 10.67 1075 664800 279320 89683252
Stomatitis 285.95 10.67 3182 662693 271516 89691056
Internal fixation of fracture 283.98 10.67 133 665742 691 89961881
Spondylolisthesis 281.22 10.67 236 665639 3839 89958733
Flushing 278.91 10.67 151 665724 88340 89874232
Lip dry 278.33 10.67 1471 664404 99484 89863088
Erythema 273.21 10.67 822 665053 228424 89734148
Depressed level of consciousness 268.93 10.67 99 665776 72685 89889887
Respiratory failure 267.23 10.67 285 665590 118133 89844439
Intentional product misuse 263.82 10.67 166 665709 89438 89873134
Calcium deficiency 263.69 10.67 148 665727 1185 89961387
Diverticulum 262.11 10.67 381 665494 11732 89950840
Cardio-respiratory arrest 261.64 10.67 70 665805 63070 89899502
Cognitive disorder 258.83 10.67 93 665782 69314 89893258
Bone loss 257.17 10.67 210 665665 3282 89959290
Peripheral venous disease 256.66 10.67 1259 664616 82662 89879910
Scoliosis 256.56 10.67 322 665553 8585 89953987
Chest discomfort 256.14 10.67 387 665488 137978 89824594
Multiple organ dysfunction syndrome 255.79 10.67 91 665784 68245 89894327
Premature delivery 255.70 10.67 6 665869 38756 89923816
Road traffic accident 249.56 10.67 1497 664378 106129 89856443
Lower limb fracture 249.10 10.67 1260 664615 83753 89878819
Leukopenia 247.29 10.67 225 665650 100485 89862087
Gastrointestinal disorder 244.55 10.67 2923 662952 253764 89708808
Rash erythematous 243.17 10.67 87 665788 65017 89897555
Jaw fracture 242.57 10.67 182 665693 2496 89960076
Anaphylactic reaction 241.78 10.67 174 665701 87350 89875222
Pulmonary embolism 241.10 10.67 367 665508 130453 89832119
Blood pressure increased 239.42 10.67 701 665174 196516 89766056
Tooth extraction 235.96 10.67 353 665522 11160 89951412
Osteoporosis 234.98 10.67 1360 664515 95171 89867401
Wrong technique in product usage process 234.65 10.67 116 665759 71455 89891117
Inappropriate schedule of product administration 234.13 10.67 467 665408 149466 89813106
Tooth loss 231.93 10.67 282 665593 7272 89955300
Mucosal inflammation 231.13 10.67 68 665807 57557 89905015
Atypical fracture 230.61 10.67 120 665755 811 89961761
Spinal compression fracture 230.21 10.67 406 665469 14772 89947800
Foetal exposure during pregnancy 229.97 10.67 24 665851 42951 89919621
Lactic acidosis 228.85 10.67 46 665829 50417 89912155
Contusion 227.71 10.67 2834 663041 248382 89714190
Dry skin 226.88 10.67 188 665687 87885 89874687
Pulmonary fibrosis 226.52 10.67 1459 664416 106044 89856528
Suicidal ideation 225.58 10.67 131 665744 73724 89888848
Ulna fracture 224.49 10.67 132 665743 1165 89961407
Loose tooth 224.34 10.67 200 665675 3543 89959029
Resorption bone increased 224.07 10.67 129 665746 1090 89961482
Drug reaction with eosinophilia and systemic symptoms 223.43 10.67 26 665849 42732 89919840
Neoplasm progression 220.56 10.67 32 665843 44454 89918118
Sedation 220.36 10.67 43 665832 48128 89914444
Neuropathy peripheral 219.61 10.67 420 665455 136550 89826022
Inflammation 219.41 10.67 2140 663735 176452 89786120
Lumbar spinal stenosis 219.26 10.67 237 665638 5360 89957212
Renal failure 218.65 10.67 392 665483 130615 89831957
Bone density decreased 218.02 10.67 428 665447 16917 89945655
Overdose 215.25 10.67 529 665346 157180 89805392
Renal impairment 212.91 10.67 277 665598 105144 89857428
Grip strength decreased 212.91 10.67 1285 664590 91291 89871281
Urinary tract infection 210.76 10.67 1347 664528 304285 89658287
Blood glucose increased 210.72 10.67 233 665642 95013 89867559
Blood parathyroid hormone decreased 210.68 10.67 346 665529 11870 89950702
Weight decreased 210.36 10.67 1782 664093 378128 89584444
Sciatica 209.97 10.67 1370 664505 100012 89862560
Breast cancer stage III 209.62 10.67 1196 664679 83251 89879321
Skin exfoliation 209.51 10.67 119 665756 67794 89894778
Influenza 207.95 10.67 445 665430 138819 89823753
Therapy interrupted 206.78 10.67 56 665819 50052 89912520
General physical health deterioration 206.37 10.67 3711 662164 351404 89611168
Rib fracture 202.41 10.67 536 665339 25899 89936673
Kyphosis 201.89 10.67 169 665706 2739 89959833
Wound infection 201.31 10.67 1406 664469 104996 89857576
Bone graft 201.10 10.67 113 665762 907 89961665
Pyrexia 200.67 10.67 3530 662345 656955 89305617
Deep vein thrombosis postoperative 199.44 10.67 1038 664837 69771 89892801
Metabolic acidosis 198.60 10.67 80 665795 55596 89906976
Fibrocystic breast disease 198.24 10.67 119 665756 1095 89961477
Blood creatinine increased 198.05 10.67 273 665602 101113 89861459
Radius fracture 197.86 10.67 193 665682 3851 89958721
Injection site swelling 196.15 10.67 97 665778 59742 89902830
Asthenia 195.25 10.67 2754 663121 530997 89431575
Musculoskeletal stiffness 194.45 10.67 3160 662715 293372 89669200
Periodontitis 194.37 10.67 187 665688 3666 89958906
Loss of consciousness 192.47 10.67 469 665406 139769 89822803
Angioedema 189.87 10.67 121 665754 64755 89897817
Chills 188.62 10.67 432 665443 131549 89831023
Granuloma skin 187.58 10.67 305 665570 10375 89952197
Edentulous 187.22 10.67 70 665805 178 89962394
Haemoglobin decreased 187.01 10.67 589 665286 161367 89801205
Pneumonia 186.57 10.67 3433 662442 634626 89327946
Tonsillar disorder 186.44 10.67 114 665761 1088 89961484
Hip fracture 186.28 10.67 601 665274 32476 89930096
Drug resistance 185.83 10.67 9 665866 30440 89932132
Oral cavity fistula 185.75 10.67 92 665783 552 89962020
Limb asymmetry 184.87 10.67 102 665773 787 89961785
Encephalopathy 184.10 10.67 56 665819 46388 89916184
Oxygen saturation decreased 182.62 10.67 318 665557 107165 89855407
Mobility decreased 182.29 10.67 2719 663156 248015 89714557
Bradycardia 181.25 10.67 209 665666 83638 89878934
Accidental exposure to product 181.24 10.67 44 665831 42322 89920250
Obesity 181.07 10.67 1362 664513 104145 89858427
Tachycardia 178.85 10.67 578 665297 157095 89805477
Colitis 178.05 10.67 151 665724 69791 89892781
Hepatic cytolysis 177.00 10.67 13 665862 30903 89931669
Large intestine polyp 174.38 10.67 275 665600 9111 89953461
Rhinorrhoea 174.32 10.67 236 665639 88080 89874492
Disturbance in attention 172.48 10.67 65 665810 47044 89915528
Agitation 171.86 10.67 144 665731 66954 89895618
Intentional self-injury 171.83 10.67 11 665864 29323 89933249
Nasal congestion 171.73 10.67 216 665659 83198 89879374
Basal cell carcinoma 170.54 10.67 587 665288 32802 89929770
Abdominal pain 170.54 10.67 1972 663903 393749 89568823
Cerumen impaction 170.07 10.67 107 665768 1079 89961493
Panniculitis 170.03 10.67 347 665528 14111 89948461
Multiple sclerosis relapse 169.62 10.67 86 665789 52219 89910353
Palpitations 169.55 10.67 481 665394 136247 89826325
Blood loss anaemia 169.23 10.67 283 665592 9857 89952715
Vision blurred 169.21 10.67 347 665528 109946 89852626
Influenza like illness 167.78 10.67 207 665668 80404 89882168
Malaise 167.46 10.67 3165 662710 582821 89379751
Rotator cuff syndrome 167.40 10.67 365 665510 15554 89947018
Unevaluable event 166.49 10.67 98 665777 54750 89907822
Autoimmune disorder 165.00 10.67 1047 664828 75697 89886875
Serotonin syndrome 164.74 10.67 38 665837 37849 89924723
Respiratory arrest 162.75 10.67 25 665850 33286 89929286
Tonsillectomy 161.63 10.67 99 665776 948 89961624
Epistaxis 161.50 10.67 234 665641 84891 89877681
Cytokine release syndrome 159.47 10.67 12 665863 27961 89934611
Gait inability 159.34 10.67 1712 664163 144744 89817828
Tibia fracture 157.99 10.67 209 665666 5878 89956694
Muscle strain 155.89 10.67 266 665609 9421 89953151
Oropharyngeal pain 155.10 10.67 389 665486 114798 89847774
Rheumatoid nodule 154.51 10.67 409 665466 19757 89942815
Periprosthetic fracture 154.03 10.67 79 665796 516 89962056
Wrist fracture 153.90 10.67 349 665526 15275 89947297
Skin discolouration 152.72 10.67 67 665808 44248 89918324
Dislocation of vertebra 152.49 10.67 813 665062 55155 89907417
Adjustment disorder with depressed mood 152.32 10.67 821 665054 55932 89906640
Incorrect dose administered 151.69 10.67 215 665660 78715 89883857
Drug tolerance decreased 151.33 10.67 550 665325 31580 89930992
Septic shock 151.32 10.67 240 665635 83920 89878652
Foot deformity 150.77 10.67 849 665026 58802 89903770
Lumbar radiculopathy 150.46 10.67 136 665739 2455 89960117
Injection site bruising 149.75 10.67 100 665775 52207 89910365
Ascites 149.64 10.67 82 665793 47658 89914914
Treatment failure 149.21 10.67 3096 662779 300832 89661740
Fistula discharge 149.19 10.67 95 665780 980 89961592
Haematochezia 148.74 10.67 181 665694 70732 89891840
Pulmonary oedema 148.49 10.67 142 665733 61938 89900634
Oral disorder 147.02 10.67 269 665606 10076 89952496
Live birth 145.33 10.67 1038 664837 78069 89884503
Depressed mood 145.15 10.67 95 665780 50127 89912445
Anaphylactic shock 145.09 10.67 28 665847 31589 89930983
Sopor 145.07 10.67 9 665866 24635 89937937
Tooth abscess 142.50 10.67 349 665526 16064 89946508
Injection site pruritus 142.28 10.67 112 665763 53722 89908850
Uterine disorder 142.14 10.67 147 665728 3154 89959418
Intentional product use issue 141.59 10.67 2310 663565 214582 89747990
Fibula fracture 141.32 10.67 165 665710 4072 89958500
Toxic epidermal necrolysis 140.69 10.67 33 665842 32495 89930077
Musculoskeletal pain 140.38 10.67 1897 663978 169354 89793218
Pelvic fracture 140.07 10.67 331 665544 14888 89947684
Gingivitis 138.72 10.67 248 665627 9121 89953451
C-reactive protein abnormal 138.34 10.67 1489 664386 125940 89836632
Dry mouth 138.04 10.67 2007 663868 182052 89780520
Patellofemoral pain syndrome 136.63 10.67 80 665795 700 89961872
Removal of internal fixation 136.25 10.67 43 665832 49 89962523
Osteitis 136.09 10.67 153 665722 3620 89958952
Fracture displacement 135.74 10.67 95 665780 1161 89961411
Stress urinary incontinence 135.16 10.67 125 665750 2327 89960245
Generalised tonic-clonic seizure 134.92 10.67 44 665831 34859 89927713
Cholestasis 134.72 10.67 49 665826 36250 89926322
Hepatic failure 133.88 10.67 62 665813 39666 89922906
Abscess jaw 132.70 10.67 100 665775 1381 89961191
Clostridium difficile infection 131.05 10.67 51 665824 36194 89926378
Aphasia 129.23 10.67 77 665798 42735 89919837
Exposed bone in jaw 129.07 10.67 132 665743 2794 89959778
Dental necrosis 128.90 10.67 46 665829 97 89962475
Meniscus injury 128.38 10.67 223 665652 8014 89954558
Cardiac failure 127.94 10.67 396 665479 109100 89853472
Hypoglycaemia 127.65 10.67 197 665678 69651 89892921
Mitral valve prolapse 127.41 10.67 124 665751 2467 89960105
Transaminases increased 126.96 10.67 57 665818 37135 89925437
Onychomycosis 126.84 10.67 578 665297 36798 89925774
Hyponatraemia 126.76 10.67 527 665348 133011 89829561
Blood bilirubin increased 125.94 10.67 82 665793 43388 89919184
Hepatotoxicity 125.47 10.67 92 665783 45750 89916822
Hyperkalaemia 124.79 10.67 177 665698 64787 89897785
Pleural effusion 123.90 10.67 415 665460 111576 89850996
Device issue 123.79 10.67 32 665843 29505 89933067
Sleep disorder 123.68 10.67 2094 663781 195936 89766636
Posterior reversible encephalopathy syndrome 123.42 10.67 11 665864 22328 89940244
Pericardial effusion 123.32 10.67 58 665817 36775 89925797
Hypoxia 123.16 10.67 214 665661 72185 89890387
Heart rate increased 123.12 10.67 421 665454 112481 89850091
Restlessness 123.10 10.67 54 665821 35666 89926906
Pneumonitis 123.04 10.67 87 665788 44083 89918489
Dental fistula 122.73 10.67 71 665804 606 89961966
Skin necrosis 122.17 10.67 336 665539 16605 89945967
Therapy cessation 122.14 10.67 57 665818 36304 89926268
Agranulocytosis 122.08 10.67 52 665823 34950 89927622
Appendix disorder 121.03 10.67 96 665779 1436 89961136
Onychomadesis 119.11 10.67 659 665216 45339 89917233
Lupus vulgaris 119.00 10.67 649 665226 44410 89918162
Caesarean section 118.38 10.67 4 665871 18573 89943999
Hospitalisation 117.61 10.67 512 665363 127588 89834984
Prescribed underdose 117.39 10.67 948 664927 74071 89888501
Adverse drug reaction 117.24 10.67 1343 664532 115358 89847214
Night sweats 116.26 10.67 1452 664423 127314 89835258
Psychotic disorder 116.17 10.67 42 665833 31188 89931384
Blood pressure decreased 115.41 10.67 235 665640 74660 89887912
Dysgeusia 114.69 10.67 130 665745 52430 89910142
Rhabdomyolysis 113.79 10.67 125 665750 51131 89911441
Throat irritation 113.44 10.67 114 665761 48581 89913991
Dysarthria 113.27 10.67 140 665735 54342 89908230
Eye pruritus 113.25 10.67 36 665839 28991 89933581
Nail disorder 113.14 10.67 783 665092 58284 89904288
Hepatocellular injury 112.83 10.67 36 665839 28922 89933650
Drug level increased 112.73 10.67 32 665843 27730 89934842
Pallor 112.55 10.67 55 665820 34110 89928462
Palmar-plantar erythrodysaesthesia syndrome 112.50 10.67 33 665842 27990 89934582
Neurotoxicity 112.29 10.67 13 665862 21454 89941118
Bone marrow failure 112.17 10.67 48 665827 32173 89930399
Atrophic vulvovaginitis 111.46 10.67 100 665775 1787 89960785
Drug withdrawal syndrome 111.39 10.67 36 665839 28687 89933885
Alveolar osteitis 111.10 10.67 82 665793 1095 89961477
No adverse event 111.10 10.67 206 665669 67776 89894796
Irritability 110.69 10.67 62 665813 35600 89926972
Haemorrhage 110.03 10.67 214 665661 69155 89893417
Oestrogen deficiency 109.88 10.67 42 665833 116 89962456
Eczema 109.77 10.67 136 665739 52734 89909838
Synovial cyst 109.68 10.67 257 665618 11495 89951077
Stress 109.47 10.67 275 665600 81120 89881452
Impaired quality of life 109.42 10.67 19 665856 23125 89939447
Cytomegalovirus infection 109.25 10.67 30 665845 26572 89936000
Retinitis 109.13 10.67 565 665310 37893 89924679
Creatinine renal clearance decreased 108.04 10.67 8 665867 18891 89943681
Disease recurrence 107.76 10.67 72 665803 37581 89924991
Pain 107.73 10.67 8604 657271 987737 88974835
Diabetic ketoacidosis 107.08 10.67 24 665851 24383 89938189
Blepharospasm 106.80 10.67 736 665139 54709 89907863
Lung disorder 106.75 10.67 1620 664255 148263 89814309
Hemiparesis 106.69 10.67 50 665825 31769 89930803
Cerebrovascular accident 106.68 10.67 505 665370 123028 89839544
Periodontal operation 106.24 10.67 30 665845 14 89962558
COVID-19 pneumonia 105.92 10.67 7 665868 18170 89944402
Dyskinesia 105.72 10.67 69 665806 36465 89926107
Disorientation 105.39 10.67 101 665774 44013 89918559
Dizziness 104.39 10.67 3417 662458 585867 89376705
Rash maculo-papular 103.41 10.67 89 665786 40844 89921728
Hallucination 103.31 10.67 205 665670 65754 89896818
Joint dislocation 103.22 10.67 620 665255 43962 89918610
Ulcer 103.15 10.67 497 665378 32385 89930187
Infusion site pain 103.13 10.67 12 665863 19726 89942846
Lacrimation increased 103.05 10.67 35 665840 27027 89935545
Cataract operation 102.84 10.67 172 665703 5991 89956581
Thrombosis 102.84 10.67 242 665633 73009 89889563
Status epilepticus 102.39 10.67 10 665865 18864 89943708
Red blood cell count decreased 101.83 10.67 114 665761 46237 89916335
Therapeutic response shortened 101.38 10.67 22 665853 22857 89939715
Burning sensation 101.29 10.67 195 665680 63257 89899315
Back injury 100.78 10.67 637 665238 45985 89916587
X-ray abnormal 100.29 10.67 624 665251 44800 89917772
Cystocele 100.04 10.67 86 665789 1448 89961124
Acute hepatic failure 99.35 10.67 22 665853 22539 89940033
Infection 99.31 10.67 3418 662457 358676 89603896
Lethargy 99.09 10.67 196 665679 62943 89899629
Syncope 99.03 10.67 570 665305 132093 89830479
Orthostatic hypotension 98.49 10.67 97 665778 41730 89920842
Swelling face 98.05 10.67 290 665585 81062 89881510
Breast disorder 97.75 10.67 111 665764 2656 89959916
Altered state of consciousness 97.61 10.67 55 665820 31477 89931095
Tendonitis 97.41 10.67 362 665513 21010 89941562
Unresponsive to stimuli 97.39 10.67 82 665793 38039 89924533
Aggression 97.28 10.67 37 665838 26631 89935941
Appendicectomy 97.26 10.67 126 665749 3470 89959102
Arthralgia 97.14 10.67 6801 659074 771721 89190851
Ligament sprain 96.91 10.67 281 665594 14318 89948254
Paraesthesia oral 96.89 10.67 56 665819 31603 89930969
Shock 96.83 10.67 45 665830 28733 89933839
Acute respiratory distress syndrome 96.30 10.67 45 665830 28641 89933931
Vaginal haemorrhage 96.15 10.67 55 665820 31216 89931356
Plasma cell myeloma 95.77 10.67 95 665780 40733 89921839
Female genital tract fistula 95.55 10.67 10 665865 17858 89944714
Dental implantation 95.51 10.67 67 665808 822 89961750
Food allergy 95.22 10.67 34 665841 25444 89937128
Device dislocation 94.49 10.67 57 665818 31425 89931147
Jaw operation 94.41 10.67 66 665809 805 89961767
Dyspnoea exertional 93.56 10.67 249 665626 72039 89890533
Rash macular 93.47 10.67 53 665822 30227 89932345
Temperature regulation disorder 93.40 10.67 3 665872 14576 89947996
Prescribed overdose 93.39 10.67 1113 664762 96512 89866060
Withdrawal syndrome 93.26 10.67 25 665850 22499 89940073
Full blood count decreased 93.04 10.67 51 665824 29638 89932934
Respiratory distress 92.07 10.67 90 665785 38856 89923716
Affect lability 91.89 10.67 12 665863 18051 89944521
Confusional state 91.67 10.67 3587 662288 382618 89579954
Vertebral foraminal stenosis 91.55 10.67 72 665803 1063 89961509
Lymphocyte count decreased 91.27 10.67 74 665801 34976 89927596
Hypervolaemia 90.61 10.67 65 665810 32692 89929880
Heavy menstrual bleeding 90.44 10.67 20 665855 20510 89942062
Femoral neck fracture 90.34 10.67 219 665656 10014 89952558
Heart rate decreased 90.23 10.67 159 665716 53346 89909226
Hyperaesthesia teeth 90.21 10.67 97 665778 2180 89960392
Neutropenic sepsis 89.97 10.67 13 665862 18117 89944455
Skin haemorrhage 89.91 10.67 23 665852 21357 89941215
Eosinophilia 89.44 10.67 49 665826 28484 89934088
Schizophrenia 89.15 10.67 5 665870 14909 89947663
Productive cough 88.40 10.67 281 665594 76782 89885790
Coma 88.20 10.67 258 665617 72374 89890198
Cytopenia 87.79 10.67 12 665863 17437 89945135
Cardiogenic shock 87.52 10.67 35 665840 24433 89938139
Abnormal behaviour 86.63 10.67 29 665846 22599 89939973
Dermatitis atopic 86.57 10.67 32 665843 23440 89939132
Carotid bruit 86.33 10.67 58 665817 660 89961912
Hypercalcaemia 86.29 10.67 487 665388 33753 89928819
Myocardial infarction 85.31 10.67 444 665431 105528 89857044
Hiatus hernia 85.16 10.67 391 665484 24970 89937602
Hypoaesthesia 84.62 10.67 2960 662915 311250 89651322
Pulpitis dental 84.17 10.67 66 665809 970 89961602
Atrial fibrillation 83.95 10.67 605 665270 133006 89829566
Device difficult to use 83.71 10.67 14 665861 17511 89945061
Dystonia 83.60 10.67 12 665863 16807 89945765
Vascular calcification 83.49 10.67 59 665816 733 89961839
Fractured sacrum 83.44 10.67 96 665779 2331 89960241
Fracture malunion 83.30 10.67 35 665840 133 89962439
Skin burning sensation 82.66 10.67 21 665854 19590 89942982
Skin fissures 82.63 10.67 25 665850 20784 89941788
Abscess oral 82.54 10.67 78 665797 1494 89961078
Osteomyelitis chronic 82.49 10.67 50 665825 469 89962103
Stevens-Johnson syndrome 81.64 10.67 58 665817 29318 89933254
C-reactive protein 81.62 10.67 450 665425 30917 89931655
Hypophagia 81.59 10.67 86 665789 35851 89926721
Fluid retention 81.51 10.67 351 665524 87740 89874832
Mydriasis 81.32 10.67 8 665867 15004 89947568
Liver disorder 81.10 10.67 1297 664578 119972 89842600
Bone lesion 81.09 10.67 159 665716 6278 89956294
Depression 81.00 10.67 2832 663043 297769 89664803
Throat tightness 80.91 10.67 59 665816 29425 89933147
Oroantral fistula 80.62 10.67 36 665839 164 89962408
Gamma-glutamyltransferase increased 80.51 10.67 96 665779 37856 89924716
Crying 80.44 10.67 44 665831 25601 89936971
Acute respiratory failure 80.40 10.67 119 665756 42799 89919773
Motor dysfunction 80.27 10.67 21 665854 19209 89943363
Injection site mass 80.00 10.67 31 665844 22059 89940513
Metastases to liver 79.89 10.67 57 665818 28750 89933822
Vaginal flatulence 79.56 10.67 3 665872 12635 89949937
Product storage error 79.15 10.67 25 665850 20216 89942356
Sneezing 79.11 10.67 62 665813 29807 89932765
Extraskeletal ossification 78.82 10.67 34 665841 140 89962432
Mood swings 78.44 10.67 27 665848 20675 89941897
Product prescribing error 78.05 10.67 64 665811 30081 89932491
Arthritis 77.99 10.67 1692 664183 165623 89796949
Wheezing 77.95 10.67 2296 663579 235784 89726788
Therapeutic product effect incomplete 77.77 10.67 981 664894 192915 89769657
Anti-cyclic citrullinated peptide antibody 77.29 10.67 400 665475 26821 89935751
Hemiplegia 76.99 10.67 13 665862 16147 89946425
Brain oedema 76.46 10.67 17 665858 17368 89945204
Product dose omission in error 75.54 10.67 28 665847 20475 89942097
Metastases to central nervous system 75.46 10.67 18 665857 17524 89945048
Dental plaque 75.13 10.67 29 665846 83 89962489
Hot flush 74.66 10.67 208 665667 59280 89903292
Humerus fracture 74.50 10.67 198 665677 9587 89952985
Biopsy bone 74.42 10.67 24 665851 31 89962541
Red blood cell sedimentation rate increased 74.38 10.67 931 664944 81664 89880908
Product label confusion 74.30 10.67 349 665526 22501 89940071
Ejection fraction decreased 74.06 10.67 51 665824 26202 89936370
Drug tolerance 73.90 10.67 294 665581 17622 89944950
Swollen tongue 73.55 10.67 141 665734 45815 89916757
Psoriasis 73.37 10.67 712 665163 147042 89815530
Patella fracture 73.35 10.67 92 665783 2451 89960121
Proctitis 73.31 10.67 12 665863 15247 89947325
Joint effusion 73.08 10.67 313 665562 19397 89943175
Poisoning 73.03 10.67 12 665863 15205 89947367
Closed fracture manipulation 72.93 10.67 21 665854 12 89962560
Haematotoxicity 72.54 10.67 5 665870 12530 89950042
Neuroleptic malignant syndrome 72.24 10.67 12 665863 15084 89947488
Injection site rash 72.22 10.67 44 665831 24129 89938443
Dyspepsia 72.11 10.67 1937 663938 196223 89766349
Varicose vein 71.42 10.67 163 665712 7164 89955408
Vaginal discharge 71.01 10.67 27 665848 19437 89943135
Injection site urticaria 70.87 10.67 22 665853 17989 89944583
Cardiotoxicity 70.70 10.67 3 665872 11386 89951186
Lymphopenia 70.70 10.67 40 665835 22841 89939731
Tachypnoea 70.65 10.67 34 665841 21275 89941297
Oral surgery 70.40 10.67 72 665803 1524 89961048
Hypomagnesaemia 70.31 10.67 95 665780 35493 89927079
Haemophagocytic lymphohistiocytosis 70.28 10.67 14 665861 15445 89947127
Seborrhoeic keratosis 70.22 10.67 101 665774 3079 89959493
Polymyalgia rheumatica 70.20 10.67 129 665746 4848 89957724
Haemorrhoids 70.10 10.67 384 665491 26318 89936254
Thrombotic microangiopathy 70.04 10.67 15 665860 15728 89946844
Laryngitis 69.70 10.67 623 665252 50130 89912442
Metastases to lung 69.60 10.67 16 665859 15975 89946597
Acne 69.59 10.67 64 665811 28443 89934129
Therapeutic response unexpected 69.42 10.67 37 665838 21843 89940729
Myoclonus 69.25 10.67 27 665848 19141 89943431
Endodontic procedure 69.01 10.67 105 665770 3370 89959202
Acute myeloid leukaemia 68.33 10.67 33 665842 20607 89941965
Intentional dose omission 67.71 10.67 23 665852 17760 89944812
Intestinal obstruction 67.58 10.67 105 665770 37026 89925546
Therapy partial responder 67.44 10.67 39 665836 22004 89940568
Bone metabolism disorder 67.34 10.67 41 665834 388 89962184
Haemoptysis 66.79 10.67 88 665787 33232 89929340
Toxic skin eruption 66.27 10.67 17 665858 15757 89946815
Spinal laminectomy 66.26 10.67 53 665822 803 89961769
Face oedema 66.18 10.67 45 665830 23273 89939299
Arthroscopy 66.16 10.67 51 665824 730 89961842
Injection site warmth 66.09 10.67 23 665852 17492 89945080
Osteoradionecrosis 65.84 10.67 29 665846 127 89962445
Device malfunction 65.78 10.67 36 665839 20941 89941631
Nightmare 65.67 10.67 39 665836 21686 89940886
Osteopetrosis 65.58 10.67 23 665852 45 89962527
Circulatory collapse 65.57 10.67 52 665823 24852 89937720
Ischaemic stroke 65.32 10.67 41 665834 22125 89940447
Candida infection 65.20 10.67 93 665782 33964 89928608
Hypokalaemia 65.03 10.67 632 665243 130484 89832088
Metastases to bone 64.98 10.67 55 665820 25450 89937122
Pruritus 64.70 10.67 3285 662590 538240 89424332
Bacteraemia 64.68 10.67 42 665833 22258 89940314
Rectocele 64.58 10.67 62 665813 1212 89961360
Blood pressure fluctuation 64.50 10.67 185 665690 52228 89910344
Sensory loss 64.41 10.67 26 665849 18049 89944523
Anuria 64.15 10.67 15 665860 14803 89947769
Blood glucose decreased 64.14 10.67 47 665828 23382 89939190
Acquired oesophageal web 64.03 10.67 33 665842 218 89962354
Mood altered 63.86 10.67 23 665852 17121 89945451
Eye swelling 63.76 10.67 73 665802 29313 89933259
Gingival recession 63.41 10.67 71 665804 1672 89960900
Hyperglycaemia 63.39 10.67 179 665696 50791 89911781
Urinary tract discomfort 63.31 10.67 53 665822 859 89961713
Tooth deposit 63.20 10.67 34 665841 248 89962324
Pancreatitis acute 63.18 10.67 86 665789 32029 89930543
Mental disorder 63.12 10.67 87 665788 32231 89930341
Akathisia 63.01 10.67 5 665870 11154 89951418
Aplastic anaemia 62.50 10.67 11 665864 13258 89949314
Blood lactate dehydrogenase increased 62.38 10.67 59 665816 25873 89936699
Lip swelling 62.20 10.67 118 665757 38492 89924080
Hysterectomy 62.10 10.67 207 665668 11377 89951195
Oedema mouth 62.04 10.67 82 665793 2304 89960268
Gestational diabetes 61.89 10.67 4 665871 10578 89951994
Injection site haemorrhage 61.82 10.67 70 665805 28248 89934324
Respiratory tract infection 61.25 10.67 225 665650 58853 89903719
Macular degeneration 61.20 10.67 116 665759 37854 89924718
Abscess 61.04 10.67 288 665587 18603 89943969
Essential hypertension 61.02 10.67 140 665735 6175 89956397
Oesophagitis 60.96 10.67 270 665605 16979 89945593
Intervertebral disc protrusion 60.91 10.67 375 665500 26821 89935751
Oedema 60.82 10.67 1914 663961 198381 89764191
Vascular device infection 60.65 10.67 8 665867 11944 89950628
Hyperbilirubinaemia 60.54 10.67 14 665861 13922 89948650
Jaw cyst 60.47 10.67 27 665848 123 89962449
Compression fracture 60.11 10.67 171 665704 8618 89953954
Lumbosacral radiculopathy 60.07 10.67 43 665832 546 89962026
Mental status changes 60.03 10.67 151 665724 44528 89918044
Blood potassium decreased 59.80 10.67 167 665708 47560 89915012
Personality disorder 59.31 10.67 10 665865 12434 89950138
Cystitis 59.21 10.67 270 665605 66448 89896124
Hypersomnia 59.19 10.67 43 665832 21488 89941084
Transplant rejection 59.17 10.67 11 665864 12747 89949825
Bone erosion 59.12 10.67 623 665252 52398 89910174
Iliotibial band syndrome 58.84 10.67 36 665839 344 89962228
Tardive dyskinesia 58.75 10.67 6 665869 10924 89951648
Hallucination, auditory 58.55 10.67 22 665853 15953 89946619
Mental impairment 58.05 10.67 25 665850 16695 89945877
Skeletal injury 58.02 10.67 59 665816 1240 89961332
Abortion induced 57.90 10.67 9 665866 11879 89950693
Respiratory depression 57.84 10.67 21 665854 15554 89947018
Hypothermia 57.84 10.67 21 665854 15554 89947018
Myocarditis 57.77 10.67 15 665860 13791 89948781
Bone sequestrum 57.75 10.67 62 665813 1391 89961181
Kidney infection 57.74 10.67 63 665812 25853 89936719
Tumour lysis syndrome 57.72 10.67 7 665868 11145 89951427
Second primary malignancy 57.63 10.67 5 665870 10373 89952199
Bone formation decreased 57.62 10.67 23 665852 74 89962498
Hand fracture 57.51 10.67 144 665731 6721 89955851
Peripheral vascular disorder 57.16 10.67 138 665737 6293 89956279
C-reactive protein increased 57.11 10.67 1741 664134 179648 89782924
Acute sinusitis 57.05 10.67 108 665767 4153 89958419
Fistula 56.97 10.67 207 665668 11882 89950690
Fracture 56.96 10.67 316 665559 21760 89940812
Infusion site erythema 56.92 10.67 15 665860 13655 89948917
Blood alkaline phosphatase increased 56.77 10.67 173 665702 47906 89914666
Peripheral swelling 56.52 10.67 3638 662237 409468 89553104
Multiple sclerosis 56.35 10.67 73 665802 27767 89934805
Osteoma 56.34 10.67 19 665856 31 89962541
Bone fragmentation 56.22 10.67 46 665829 721 89961851
Balance disorder 56.05 10.67 450 665425 96630 89865942
Spinal fracture 56.05 10.67 314 665561 21702 89940870
Lupus-like syndrome 55.90 10.67 577 665298 48269 89914303
Haematocrit decreased 55.73 10.67 142 665733 41690 89920882
Hepatic encephalopathy 55.68 10.67 16 665859 13756 89948816
Alanine aminotransferase increased 55.53 10.67 578 665297 117760 89844812
Rash papular 55.51 10.67 41 665834 20314 89942258
Actinomycosis 55.17 10.67 54 665821 1082 89961490
Adenotonsillectomy 55.17 10.67 20 665855 45 89962527
Acetabulum fracture 55.14 10.67 36 665839 389 89962183
Feeding disorder 54.99 10.67 30 665845 17482 89945090
Needle issue 54.86 10.67 17 665858 13917 89948655
Pulmonary arterial hypertension 54.74 10.67 67 665808 26120 89936452
Haemodynamic instability 54.71 10.67 10 665865 11729 89950843
Right ventricular failure 54.59 10.67 37 665838 19168 89943404
Hepatic function abnormal 54.34 10.67 167 665708 46121 89916451
Pain of skin 54.34 10.67 25 665850 16057 89946515
Feeling hot 54.09 10.67 343 665532 77665 89884907
Breast calcifications 54.07 10.67 59 665816 1349 89961223
Biopsy breast 54.04 10.67 31 665844 260 89962312
Drug dose omission by device 54.01 10.67 6 665869 10225 89952347
Generalised oedema 53.76 10.67 37 665838 19016 89943556
Muscle rigidity 53.63 10.67 19 665856 14290 89948282
Breast conserving surgery 53.25 10.67 54 665821 1131 89961441
International normalised ratio increased 53.24 10.67 174 665701 47142 89915430
Spinal meningeal cyst 53.14 10.67 18 665857 30 89962542
Blood creatine phosphokinase increased 53.05 10.67 106 665769 33917 89928655
Extrapyramidal disorder 52.56 10.67 27 665848 16276 89946296
Amenorrhoea 52.49 10.67 11 665864 11711 89950861
Peptic ulcer 52.48 10.67 121 665754 5354 89957218
Walking aid user 52.48 10.67 443 665432 35063 89927509
Inflammatory marker increased 52.39 10.67 4 665871 9210 89953362
Hypertensive crisis 52.26 10.67 33 665842 17751 89944821
Torsade de pointes 52.24 10.67 23 665852 15159 89947413
Osteonecrosis of external auditory canal 52.22 10.67 26 665849 158 89962414
Kyphoscoliosis 52.14 10.67 38 665837 497 89962075
Pharyngeal swelling 52.07 10.67 6 665869 9938 89952634
Lymphadenopathy 51.73 10.67 168 665707 45607 89916965
Speech disorder 51.73 10.67 167 665708 45418 89917154
Back pain 51.65 10.67 1858 664017 315317 89647255
Muscle twitching 51.57 10.67 61 665814 24141 89938431
Red blood cell sedimentation rate 51.50 10.67 109 665766 4549 89958023
Product administration interrupted 51.46 10.67 14 665861 12478 89950094
Cardiac murmur 51.41 10.67 267 665608 17927 89944645
Stress cardiomyopathy 51.33 10.67 17 665858 13338 89949234
Sequestrectomy 50.98 10.67 44 665831 745 89961827
Chemical burn of respiratory tract 50.97 10.67 13 665862 0 89962572
Ventricular tachycardia 50.82 10.67 64 665811 24644 89937928
Fall 50.70 10.67 4154 661721 477656 89484916
Pulmonary congestion 50.63 10.67 41 665834 19392 89943180
Sinus congestion 50.43 10.67 77 665798 27347 89935225
Neutrophil count increased 50.41 10.67 41 665834 19349 89943223
Dysstasia 50.38 10.67 66 665809 24986 89937586
Localised infection 50.27 10.67 107 665768 33455 89929117
Angiopathy 50.23 10.67 119 665756 5361 89957211
Renal tubular necrosis 50.16 10.67 22 665853 14533 89948039
Mycotic allergy 50.13 10.67 50 665825 1026 89961546
Reversible airways obstruction 49.80 10.67 67 665808 1916 89960656
Nervous system disorder 49.78 10.67 51 665824 21542 89941030
Tubulointerstitial nephritis 49.72 10.67 68 665807 25275 89937297
Suspected suicide 49.54 10.67 6 665869 9562 89953010
Petechiae 49.38 10.67 27 665848 15714 89946858
Retching 49.20 10.67 41 665834 19118 89943454
Debridement 49.12 10.67 53 665822 1196 89961376
Genital haemorrhage 48.85 10.67 4 665871 8698 89953874
Scapula fracture 48.72 10.67 35 665840 447 89962125
Liver function test abnormal 48.64 10.67 200 665675 50645 89911927
Complication of device insertion 48.40 10.67 9 665866 10427 89952145
Myalgia 48.28 10.67 951 664924 174174 89788398
Product dispensing error 48.27 10.67 15 665860 12258 89950314
Hereditary angioedema 48.17 10.67 6 665869 9359 89953213
Vital capacity decreased 48.05 10.67 63 665812 1756 89960816
Tenosynovitis stenosans 47.82 10.67 96 665779 3857 89958715
Procedural pain 47.79 10.67 109 665766 33251 89929321
Hyperthermia 47.74 10.67 9 665866 10326 89952246
Blood test abnormal 47.72 10.67 50 665825 20902 89941670
Oral candidiasis 47.50 10.67 120 665755 35335 89927237
Staphylococcal infection 47.30 10.67 189 665686 48250 89914322
Renal injury 47.15 10.67 9 665866 10234 89952338
Oral fibroma 46.97 10.67 17 665858 38 89962534
Ankle fracture 46.96 10.67 283 665592 20087 89942485
Cerebral haemorrhage 46.91 10.67 116 665759 34406 89928166
Emotional distress 46.89 10.67 127 665748 36535 89926037
Anaemia of chronic disease 46.83 10.67 75 665800 2518 89960054
Gangrene 46.74 10.67 18 665857 12858 89949714
Exposure to toxic agent 46.63 10.67 3 665872 7964 89954608
Urinary bladder suspension 46.40 10.67 35 665840 484 89962088
Vertigo 46.35 10.67 311 665564 69500 89893072
Glomerular filtration rate decreased 46.31 10.67 34 665841 16898 89945674
Nasal septum deviation 46.30 10.67 64 665811 1879 89960693
Finger deformity 46.29 10.67 406 665469 32491 89930081
Electrolyte imbalance 46.29 10.67 64 665811 23681 89938891
Red cell distribution width increased 46.11 10.67 16 665859 12191 89950381
Flatulence 45.94 10.67 153 665722 41214 89921358
Seronegative arthritis 45.72 10.67 259 665616 17975 89944597
Breast cancer stage II 45.61 10.67 428 665447 34906 89927666
Oliguria 45.51 10.67 11 665864 10613 89951959
Bunion operation 45.49 10.67 53 665822 1305 89961267
Blood calcium decreased 45.39 10.67 96 665779 30086 89932486
Comminuted fracture 45.34 10.67 35 665840 502 89962070
Device occlusion 45.27 10.67 7 665868 9275 89953297
Proteinuria 45.18 10.67 63 665812 23228 89939344
Dysphonia 44.97 10.67 275 665600 62809 89899763
Skin ulcer 44.89 10.67 564 665311 49511 89913061
Carotid artery stenosis 44.80 10.67 112 665763 5222 89957350
Cyanosis 44.79 10.67 46 665829 19409 89943163
Viral infection 44.75 10.67 155 665720 41259 89921313
Carotid artery disease 44.72 10.67 58 665817 1599 89960973
Mania 44.64 10.67 24 665851 14100 89948472
Photosensitivity reaction 44.64 10.67 39 665836 17768 89944804
Aortic arteriosclerosis 44.52 10.67 141 665734 7543 89955029
Head discomfort 44.41 10.67 33 665842 16300 89946272
Polyneuropathy 44.23 10.67 46 665829 19295 89943277
Renal disorder 44.15 10.67 137 665738 37722 89924850
Dental prosthesis placement 43.96 10.67 18 665857 63 89962509
Varicose vein operation 43.89 10.67 14 665861 17 89962555
Insurance issue 43.81 10.67 13 665862 10945 89951627
Abdominal pain lower 43.72 10.67 98 665777 30079 89932493
Therapy change 43.63 10.67 5 665870 8317 89954255
Dysphagia 43.54 10.67 572 665303 111706 89850866
Progressive multifocal leukoencephalopathy 43.38 10.67 31 665844 15624 89946948
Postmenopause 43.35 10.67 19 665856 82 89962490
Intraocular lens implant 43.25 10.67 30 665845 361 89962211
Product preparation error 43.22 10.67 11 665864 10250 89952322
Animal scratch 43.19 10.67 60 665815 1770 89960802
SARS-CoV-2 test positive 43.06 10.67 14 665861 11114 89951458
Gingival bleeding 43.01 10.67 220 665655 14683 89947889
Aspergillus infection 42.98 10.67 13 665862 10810 89951762
Poor venous access 42.92 10.67 48 665827 19479 89943093
Meniscus removal 42.88 10.67 15 665860 29 89962543
Ventricular fibrillation 42.75 10.67 25 665850 14019 89948553
Respiratory syncytial virus infection 42.70 10.67 12 665863 10468 89952104
Injection site induration 42.62 10.67 12 665863 10456 89952116
Arterial occlusive disease 42.59 10.67 19 665856 12427 89950145
Sinusitis 42.56 10.67 2997 662878 340091 89622481
Accidental overdose 42.46 10.67 90 665785 28183 89934389
Coeliac disease 42.39 10.67 508 665367 44102 89918470
Taste disorder 42.17 10.67 661 665214 60885 89901687
Pernicious anaemia 42.15 10.67 41 665834 815 89961757
Dry eye 42.10 10.67 251 665624 57680 89904892
Sjogren's syndrome 41.93 10.67 45 665830 1009 89961563
Interstitial lung disease 41.91 10.67 359 665516 76046 89886526
Jaundice cholestatic 41.86 10.67 11 665864 10032 89952540
Maternal exposure timing unspecified 41.85 10.67 296 665579 22187 89940385
Sputum culture positive 41.84 10.67 66 665809 2187 89960385
Barrett's oesophagus 41.76 10.67 34 665841 529 89962043
Dental prosthesis user 41.65 10.67 16 665859 45 89962527
Mixed liver injury 41.45 10.67 4 665871 7619 89954953
Gastrointestinal haemorrhage 41.44 10.67 443 665432 89805 89872767
Pneumocystis jirovecii pneumonia 41.40 10.67 59 665816 21557 89941015
Blood pressure abnormal 41.34 10.67 50 665825 19595 89942977
Product prescribing issue 41.32 10.67 5 665870 7974 89954598
Pharyngitis streptococcal 41.23 10.67 21 665854 12721 89949851
Rheumatoid arthritis 41.10 10.67 2211 663664 360403 89602169
Type V hyperlipidaemia 40.88 10.67 41 665834 847 89961725
Purulence 40.85 10.67 55 665820 1574 89960998
Atrophy 40.79 10.67 63 665812 2049 89960523
Back disorder 40.68 10.67 325 665550 25306 89937266
Bladder repair 40.68 10.67 19 665856 98 89962474
Tenosynovitis 40.62 10.67 213 665662 14354 89948218
Osteomalacia 40.61 10.67 41 665834 854 89961718
External fixation of fracture 40.50 10.67 11 665864 3 89962569
Intestinal perforation 40.46 10.67 26 665849 13855 89948717
Hallucination, visual 40.42 10.67 67 665808 23025 89939547
Glycosylated haemoglobin increased 40.34 10.67 33 665842 15529 89947043
Labelled drug-drug interaction medication error 40.25 10.67 29 665846 14553 89948019
Delusion 40.23 10.67 26 665849 13814 89948758
Coordination abnormal 40.21 10.67 59 665816 21297 89941275
Increased appetite 40.20 10.67 18 665857 11747 89950825
Full blood count abnormal 40.20 10.67 136 665739 36461 89926111
Diplopia 40.19 10.67 95 665780 28619 89933953
Disseminated intravascular coagulation 40.07 10.67 60 665815 21478 89941094
Malocclusion 39.98 10.67 20 665855 123 89962449
Eustachian tube dysfunction 39.95 10.67 38 665837 734 89961838
Pathogen resistance 39.85 10.67 6 665869 8109 89954463
Infective pulmonary exacerbation of cystic fibrosis 39.65 10.67 13 665862 10266 89952306
Decreased immune responsiveness 39.61 10.67 8 665867 8740 89953832
Oesophageal ulcer 39.39 10.67 104 665771 5015 89957557
Breast cancer metastatic 39.33 10.67 32 665843 15100 89947472
Scleritis 39.26 10.67 105 665770 5103 89957469
Dialysis 39.24 10.67 17 665858 11312 89951260
Sickle cell anaemia with crisis 39.23 10.67 4 665871 7293 89955279
Trismus 39.21 10.67 100 665775 4721 89957851
Eating disorder 39.19 10.67 93 665782 27980 89934592
Adenoidal disorder 39.17 10.67 21 665854 152 89962420
Spinal disorder 39.17 10.67 180 665695 11499 89951073
Apathy 39.15 10.67 16 665859 11024 89951548
Intervertebral disc disorder 39.08 10.67 108 665767 5352 89957220
Tunnel vision 39.00 10.67 55 665820 1646 89960926
Bradyphrenia 38.86 10.67 5 665870 7607 89954965
Spinal fusion surgery 38.77 10.67 186 665689 12097 89950475
Psychomotor hyperactivity 38.73 10.67 23 665852 12790 89949782
Dyslipidaemia 38.63 10.67 162 665713 9945 89952627
End stage renal disease 38.47 10.67 8 665867 8563 89954009
Shock haemorrhagic 38.42 10.67 21 665854 12224 89950348
Jaundice 38.40 10.67 117 665758 32400 89930172
Pulmonary hypertension 38.38 10.67 171 665704 42352 89920220
Urinary retention 38.31 10.67 145 665730 37599 89924973
Anger 38.24 10.67 27 665848 13693 89948879
Urge incontinence 38.23 10.67 46 665829 1173 89961399
Ulcer haemorrhage 38.16 10.67 327 665548 25994 89936578
Acute generalised exanthematous pustulosis 38.15 10.67 27 665848 13676 89948896
Bruxism 38.11 10.67 93 665782 4270 89958302
Upper respiratory tract infection 38.08 10.67 688 665187 127630 89834942
Steroid therapy 37.97 10.67 20 665855 139 89962433
Blood lactic acid increased 37.77 10.67 9 665866 8769 89953803
Dermal sinus 37.55 10.67 13 665862 24 89962548
Arteriosclerosis coronary artery 37.55 10.67 155 665720 9448 89953124
Emotional disorder 37.41 10.67 33 665842 14964 89947608
Multiple drug therapy 37.28 10.67 4 665871 7005 89955567
Hyperaesthesia 37.16 10.67 16 665859 10686 89951886
Osteomyelitis acute 37.10 10.67 25 665850 286 89962286
Nasal oedema 37.04 10.67 3 665872 6581 89955991
Middle insomnia 37.01 10.67 41 665834 16710 89945862
Hair follicle tumour benign 36.96 10.67 28 665847 390 89962182
Thoracic vertebral fracture 36.95 10.67 106 665769 5368 89957204
Actinic keratosis 36.88 10.67 76 665799 3112 89959460
Post transplant lymphoproliferative disorder 36.87 10.67 4 665871 6945 89955627
Nephropathy toxic 36.66 10.67 24 665851 12664 89949908
Cardiac failure acute 36.65 10.67 21 665854 11908 89950664
Hepatic cirrhosis 36.62 10.67 661 665214 62592 89899980
Hormone therapy 36.61 10.67 10 665865 3 89962569
Paranoia 36.51 10.67 25 665850 12883 89949689
Bedridden 36.45 10.67 22 665853 12126 89950446
Incisional drainage 36.38 10.67 29 665846 437 89962135
Parkinsonism 36.24 10.67 30 665845 14035 89948537
Cataract 36.15 10.67 737 665138 71355 89891217
Pneumonia viral 36.14 10.67 10 665865 8813 89953759
Skin plaque 36.12 10.67 14 665861 9961 89952611
Porphyria acute 36.03 10.67 241 665634 17734 89944838
Rebound effect 35.97 10.67 12 665863 9372 89953200
Carpal tunnel decompression 35.83 10.67 42 665833 1041 89961531
Blood sodium decreased 35.81 10.67 95 665780 27518 89935054
Hypothyroidism 35.80 10.67 569 665306 52558 89910014
Spinal stenosis 35.77 10.67 235 665640 17189 89945383
Bone fistula 35.70 10.67 15 665860 57 89962515
Inappropriate antidiuretic hormone secretion 35.64 10.67 55 665820 19450 89943122
Hyperparathyroidism 35.64 10.67 77 665798 3260 89959312
Staphylococcal bacteraemia 35.60 10.67 6 665869 7463 89955109
Blindness 35.53 10.67 90 665785 26478 89936094
Infusion site swelling 35.48 10.67 21 665854 11699 89950873
Dermatitis acneiform 35.45 10.67 3 665872 6351 89956221
Arrhythmia 35.40 10.67 175 665700 42157 89920415
Spondylitis 35.29 10.67 201 665674 13977 89948595
Ilium fracture 35.27 10.67 19 665856 139 89962433
Weight increased 35.20 10.67 3546 662329 414381 89548191
Product use in unapproved indication 35.20 10.67 2066 663809 334170 89628402
Coagulopathy 35.09 10.67 74 665801 23215 89939357
Central nervous system lesion 35.07 10.67 21 665854 11625 89950947
Intermenstrual bleeding 34.99 10.67 12 665863 9211 89953361
Infusion site extravasation 34.98 10.67 16 665859 10312 89952260
Hepatomegaly 34.86 10.67 28 665847 13298 89949274
Eye irritation 34.83 10.67 130 665745 33848 89928724
Klebsiella infection 34.80 10.67 16 665859 10281 89952291
Pre-existing condition improved 34.67 10.67 12 665863 9157 89953415
Drug level decreased 34.67 10.67 14 665861 9716 89952856
Left ventricular dysfunction 34.56 10.67 34 665841 14635 89947937
Clostridium difficile colitis 34.54 10.67 92 665783 26614 89935958
Traumatic ulcer 34.41 10.67 14 665861 48 89962524
Hypertonic bladder 34.14 10.67 89 665786 4259 89958313
Blood urea increased 34.10 10.67 112 665763 30301 89932271
Blood magnesium decreased 34.03 10.67 39 665836 15654 89946918
Initial insomnia 33.82 10.67 13 665862 9297 89953275
Graft versus host disease 33.79 10.67 9 665866 8135 89954437
Lung opacity 33.72 10.67 3 665872 6099 89956473
Presyncope 33.72 10.67 120 665755 31685 89930887
Respiratory acidosis 33.63 10.67 9 665866 8110 89954462
Blood pressure diastolic decreased 33.51 10.67 94 665781 26732 89935840
Intermittent claudication 33.30 10.67 53 665822 1770 89960802
Embolism 33.20 10.67 14 665861 9467 89953105
Subarachnoid haemorrhage 33.18 10.67 50 665825 17854 89944718
Sensitivity to weather change 33.13 10.67 12 665863 8902 89953670
Peripheral coldness 32.96 10.67 32 665843 13860 89948712
Nocturia 32.88 10.67 156 665719 10099 89952473
Cold sweat 32.75 10.67 33 665842 14048 89948524
Electrocardiogram QRS complex prolonged 32.69 10.67 7 665868 7341 89955231
Immune reconstitution inflammatory syndrome 32.67 10.67 6 665869 7013 89955559
Oral herpes 32.61 10.67 131 665744 33393 89929179
Mastication disorder 32.57 10.67 62 665813 2394 89960178
Morton's neuralgia 32.39 10.67 14 665861 58 89962514
Pharyngeal oedema 32.35 10.67 32 665843 13739 89948833
Acute myocardial infarction 32.28 10.67 139 665736 34751 89927821
Benign neoplasm of skin 32.28 10.67 19 665856 168 89962404
Encephalitis 32.25 10.67 21 665854 11113 89951459
Injection site extravasation 32.09 10.67 13 665862 9006 89953566
Neurectomy 32.01 10.67 9 665866 4 89962568
Pain in jaw 31.98 10.67 513 665362 47472 89915100
Peritonitis 31.93 10.67 60 665815 19645 89942927
Phlebolith 31.93 10.67 21 665854 230 89962342
Cardiac failure congestive 31.92 10.67 521 665354 98173 89864399
Ataxia 31.90 10.67 52 665823 17990 89944582
Wrong technique in device usage process 31.89 10.67 3 665872 5832 89956740
Ocular hyperaemia 31.67 10.67 134 665741 33664 89928908
Miosis 31.65 10.67 15 665860 9469 89953103
Immunodeficiency 31.58 10.67 187 665688 43047 89919525
Device leakage 31.54 10.67 17 665858 9974 89952598
Menstruation irregular 31.43 10.67 10 665865 8050 89954522
Hospice care 31.39 10.67 16 665859 9688 89952884
Clonus 31.31 10.67 3 665872 5747 89956825
Hyperammonaemia 31.31 10.67 5 665870 6470 89956102
Sinus tachycardia 31.29 10.67 106 665769 28407 89934165
Exposure via skin contact 31.27 10.67 20 665855 10685 89951887
Immune thrombocytopenia 31.26 10.67 31 665844 13295 89949277
Thyroid neoplasm 31.26 10.67 82 665793 3939 89958633
Bone formation increased 31.18 10.67 18 665857 153 89962419
Plantar fasciitis 31.05 10.67 85 665790 4189 89958383
Bronchospasm 31.04 10.67 66 665809 20643 89941929
Vasculitis 31.03 10.67 76 665799 22617 89939955
Catatonia 30.86 10.67 4 665871 6052 89956520
Respiration abnormal 30.84 10.67 10 665865 7953 89954619
Lipase increased 30.79 10.67 22 665853 11089 89951483
Body temperature increased 30.78 10.67 197 665678 44513 89918059
Atrial septal defect 30.75 10.67 11 665864 8223 89954349
Rhinoplasty 30.73 10.67 9 665866 6 89962566
Haemolysis 30.72 10.67 12 665863 8498 89954074
Dissociation 30.70 10.67 6 665869 6709 89955863
Thirst 30.70 10.67 45 665830 16250 89946322
Treatment noncompliance 30.68 10.67 238 665637 51489 89911083
Epstein-Barr virus infection 30.66 10.67 19 665856 10325 89952247
Catheter site infection 30.66 10.67 3 665872 5651 89956921
Eye injury 30.64 10.67 161 665714 10859 89951713
Oophorectomy 30.63 10.67 32 665843 695 89961877
Dental alveolar anomaly 30.62 10.67 13 665862 51 89962521
Oesophageal stenosis 30.61 10.67 79 665796 3757 89958815
Postmenopausal haemorrhage 30.58 10.67 60 665815 2370 89960202
Haemodialysis 30.49 10.67 13 665862 8734 89953838
Impaired fasting glucose 30.44 10.67 23 665852 319 89962253
Blood potassium increased 30.37 10.67 67 665808 20682 89941890
Faeces discoloured 30.27 10.67 70 665805 21250 89941322
Coronary artery disease 30.26 10.67 379 665496 33244 89929328
Toxic encephalopathy 30.21 10.67 13 665862 8686 89953886
Nasopharyngitis 30.19 10.67 3425 662450 403679 89558893
Gastrointestinal infection 30.14 10.67 22 665853 10968 89951604
Injection site discomfort 30.09 10.67 4 665871 5936 89956636
Metastases to lymph nodes 30.03 10.67 25 665850 11664 89950908
Delirium 30.03 10.67 991 664884 103368 89859204
Herpes zoster 29.83 10.67 502 665373 94142 89868430
Post procedural constipation 29.82 10.67 16 665859 116 89962456
Loss of employment 29.73 10.67 67 665808 2920 89959652
Ovarian disorder 29.72 10.67 35 665840 872 89961700
Drug eruption 29.71 10.67 394 665481 35013 89927559
Pancreatitis 29.60 10.67 349 665526 69477 89893095
Stupor 29.49 10.67 3 665872 5479 89957093
Acidosis 29.45 10.67 30 665845 12706 89949866
Post procedural fever 29.27 10.67 25 665850 417 89962155
Urethral caruncle 29.25 10.67 14 665861 77 89962495
Injection site discolouration 29.22 10.67 16 665859 9304 89953268
Hyperprolactinaemia 29.15 10.67 3 665872 5430 89957142
Diverticulitis 29.15 10.67 203 665672 44984 89917588
Drug effect less than expected 29.10 10.67 5 665870 6133 89956439
Rash 29.05 10.67 6439 659436 789661 89172911
Product substitution issue 29.04 10.67 55 665820 17953 89944619
Ventricular septal defect 28.98 10.67 3 665872 5404 89957168
Muscle spasticity 28.98 10.67 147 665728 35175 89927397
Lung neoplasm 28.97 10.67 112 665763 6623 89955949
Senile osteoporosis 28.95 10.67 20 665855 239 89962333
Nail operation 28.92 10.67 51 665824 1855 89960717
Haemolytic anaemia 28.86 10.67 26 665849 11671 89950901
Gingivectomy 28.84 10.67 8 665867 3 89962569
Incorrect dose administered by device 28.73 10.67 4 665871 5733 89956839
Anhedonia 28.70 10.67 25 665850 11406 89951166
Renal cyst 28.64 10.67 178 665697 12772 89949800
Tendon disorder 28.48 10.67 111 665764 6589 89955983
Tongue disorder 28.38 10.67 156 665719 10704 89951868
Nervousness 28.35 10.67 141 665734 33915 89928657
Uterine prolapse 28.33 10.67 43 665832 1377 89961195
Oesophageal disorder 28.29 10.67 62 665813 2651 89959921
Radicular pain 28.29 10.67 26 665849 480 89962092
Adjustment disorder 28.18 10.67 18 665857 9624 89952948
Cardiomyopathy 28.16 10.67 67 665808 20139 89942433
Breast cancer female 28.15 10.67 41 665834 14845 89947727
Adverse reaction 28.07 10.67 338 665537 29374 89933198
White blood cell count abnormal 28.06 10.67 10 665865 7494 89955078
Diabetes mellitus 27.98 10.67 323 665552 64552 89898020
Hypoalbuminaemia 27.94 10.67 46 665829 15851 89946721
Enterocele 27.90 10.67 12 665863 49 89962523
Acute pulmonary oedema 27.84 10.67 18 665857 9562 89953010
Synovial fluid analysis 27.81 10.67 63 665812 2755 89959817
Ketoacidosis 27.79 10.67 4 665871 5591 89956981
Brain injury 27.79 10.67 11 665864 7727 89954845
Cerebral infarction 27.76 10.67 101 665774 26495 89936077
Paralysis 27.74 10.67 26 665849 11452 89951120
Hunger 27.71 10.67 7 665868 6556 89956016
Cholecystectomy 27.54 10.67 164 665711 11591 89950981
Hypocalcaemia 27.50 10.67 190 665685 42178 89920394
Benign breast lump removal 27.45 10.67 7 665868 0 89962572
Spondylolysis 27.42 10.67 16 665859 139 89962433
Hypercalciuria 27.41 10.67 23 665852 374 89962198
Peripheral sensory neuropathy 27.41 10.67 17 665858 9233 89953339
Lumbar vertebral fracture 27.31 10.67 118 665757 7340 89955232
Maternal drugs affecting foetus 27.27 10.67 3 665872 5152 89957420
Drug specific antibody present 27.25 10.67 4 665871 5510 89957062
Escherichia infection 27.01 10.67 47 665828 15848 89946724
Menstrual disorder 27.00 10.67 6 665869 6132 89956440
Tumour marker increased 26.95 10.67 5 665870 5802 89956770
Hepatic necrosis 26.93 10.67 7 665868 6431 89956141
Epilepsy 26.92 10.67 793 665082 81413 89881159
Cholelithiasis 26.91 10.67 251 665624 52255 89910317
Device related infection 26.86 10.67 98 665777 25688 89936884
Small intestinal obstruction 26.82 10.67 74 665801 21160 89941412
Mammogram abnormal 26.81 10.67 32 665843 809 89961763
Diabetes mellitus inadequate control 26.80 10.67 61 665814 18623 89943949
Troponin increased 26.70 10.67 35 665840 13246 89949326
Immune effector cell-associated neurotoxicity syndrome 26.69 10.67 5 665870 5763 89956809
Chondromalacia 26.65 10.67 21 665854 311 89962261
Polyarthritis 26.62 10.67 228 665647 18122 89944450
Dermal cyst 26.59 10.67 53 665822 2118 89960454
Leukoplakia 26.50 10.67 14 665861 98 89962474
Atrioventricular block 26.40 10.67 16 665859 8799 89953773
Hypotonia 26.32 10.67 27 665848 11399 89951173
Body height decreased 26.28 10.67 164 665711 11785 89950787
Expired product administered 26.27 10.67 9 665866 6913 89955659
Pulmonary haemorrhage 26.24 10.67 13 665862 8000 89954572
Emphysema 26.22 10.67 166 665709 11989 89950583
Renal function test abnormal 26.19 10.67 10 665865 7181 89955391
Bronchopulmonary aspergillosis 26.19 10.67 27 665848 11371 89951201
Skin irritation 26.18 10.67 37 665838 13566 89949006
Post laminectomy syndrome 26.15 10.67 21 665854 320 89962252
Chronic kidney disease 26.13 10.67 239 665636 49952 89912620
Respiratory tract congestion 26.10 10.67 108 665767 27302 89935270
Urosepsis 26.08 10.67 75 665800 21157 89941415
Skin mass 25.97 10.67 11 665864 7419 89955153
Breast cyst 25.97 10.67 51 665824 2016 89960556
Scab 25.97 10.67 20 665855 9701 89952871
Periostitis 25.90 10.67 24 665851 448 89962124
Wrong product administered 25.77 10.67 12 665863 7653 89954919
Purpura 25.75 10.67 43 665832 14735 89947837
Diverticulum intestinal 25.72 10.67 134 665741 9008 89953564
Carpal tunnel syndrome 25.67 10.67 279 665596 23649 89938923
Hypovolaemic shock 25.61 10.67 10 665865 7084 89955488
Vertebroplasty 25.61 10.67 22 665853 370 89962202
Pneumothorax 25.58 10.67 65 665810 19102 89943470
Dermatitis exfoliative generalised 25.56 10.67 5 665870 5588 89956984
Catheter site erythema 25.51 10.67 3 665872 4891 89957681
Migraine 25.50 10.67 1674 664201 188718 89773854
Cerebral small vessel ischaemic disease 25.46 10.67 36 665839 1080 89961492
Staphylococcal sepsis 25.46 10.67 19 665856 9364 89953208
Jaw fistula 25.37 10.67 12 665863 64 89962508
Dermatitis bullous 25.37 10.67 23 665852 10293 89952279
Immune system disorder 25.37 10.67 30 665845 11875 89950697
Joint destruction 25.36 10.67 176 665699 13111 89949461
Neuroma 25.34 10.67 24 665851 461 89962111
Extra dose administered 25.34 10.67 18 665857 9100 89953472
Personality change 25.33 10.67 11 665864 7310 89955262
Cytomegalovirus viraemia 25.31 10.67 12 665863 7574 89954998
Enthesopathy 25.20 10.67 136 665739 9268 89953304
Avulsion fracture 25.17 10.67 20 665855 300 89962272
Gastritis 25.12 10.67 439 665436 41314 89921258
Subcutaneous drug absorption impaired 25.02 10.67 178 665697 13367 89949205
Joint dislocation reduction 24.95 10.67 8 665867 10 89962562
Lip neoplasm 24.95 10.67 8 665867 10 89962562
Temperature intolerance 24.91 10.67 31 665844 11999 89950573
Tonsillitis 24.87 10.67 10 665865 6959 89955613
Sarcoidosis 24.84 10.67 25 665850 10648 89951924
Myelodysplastic syndrome 24.83 10.67 75 665800 20828 89941744
Deep vein thrombosis 24.79 10.67 499 665376 91121 89871451
Lung neoplasm malignant 24.79 10.67 93 665782 24180 89938392
Nystagmus 24.78 10.67 11 665864 7216 89955356
Faecaloma 24.78 10.67 24 665851 10407 89952165
Hepatitis acute 24.77 10.67 26 665849 10861 89951711
Haemorrhoid operation 24.66 10.67 23 665852 433 89962139
Eyelid oedema 24.65 10.67 29 665846 11505 89951067
Melaena 24.64 10.67 152 665723 34645 89927927
Skin disorder 24.62 10.67 163 665712 36543 89926029
Aspartate aminotransferase increased 24.57 10.67 572 665303 102365 89860207
Meningitis 24.56 10.67 16 665859 8465 89954107
Arteriosclerosis 24.52 10.67 150 665725 10703 89951869
Epicondylitis 24.50 10.67 57 665818 2537 89960035
Impaired gastric emptying 24.50 10.67 35 665840 12774 89949798
Blood uric acid increased 24.48 10.67 13 665862 7691 89954881
Euphoric mood 24.38 10.67 5 665870 5404 89957168
Urine calcium increased 24.36 10.67 12 665863 71 89962501
Traumatic fracture 24.33 10.67 29 665846 732 89961840
Anal abscess 24.27 10.67 6 665869 5702 89956870
Drug effective for unapproved indication 24.24 10.67 14 665861 7904 89954668
Enteritis 24.22 10.67 24 665851 10297 89952275
Psychiatric symptom 24.15 10.67 11 665864 7107 89955465
Demyelination 24.06 10.67 15 665860 8125 89954447
Blood albumin decreased 23.99 10.67 55 665820 16748 89945824
Hyperparathyroidism primary 23.98 10.67 23 665852 449 89962123
Peri-implantitis 23.96 10.67 12 665863 74 89962498
Pulmonary thrombosis 23.83 10.67 22 665853 9760 89952812
Blood creatinine decreased 23.83 10.67 9 665866 6506 89956066
Upper limb fracture 23.79 10.67 253 665622 21325 89941247
Coma scale abnormal 23.76 10.67 6 665869 5620 89956952
Hypogammaglobulinaemia 23.72 10.67 26 665849 10648 89951924
Infusion site pruritus 23.67 10.67 10 665865 6755 89955817
Forearm fracture 23.67 10.67 26 665849 599 89961973
Dupuytren's contracture 23.57 10.67 12 665863 77 89962495
Uveitis 23.57 10.67 51 665824 15852 89946720
Rash pustular 23.56 10.67 15 665860 8034 89954538
Bladder pain 23.55 10.67 58 665817 2679 89959893
Tendon sheath lesion excision 23.53 10.67 6 665869 0 89962572
Traumatic occlusion 23.53 10.67 6 665869 0 89962572
Gastrooesophageal cancer 23.53 10.67 6 665869 0 89962572
Radiotherapy to breast 23.53 10.67 6 665869 0 89962572
Vaginal disorder 23.45 10.67 28 665847 708 89961864
Grief reaction 23.45 10.67 18 665857 256 89962316
Raynaud's phenomenon 23.24 10.67 35 665840 1113 89961459
Joint injury 23.21 10.67 353 665522 32311 89930261
Bacterial infection 23.19 10.67 91 665784 23353 89939219
Incorrect drug administration rate 23.19 10.67 5 665870 5218 89957354
Skin reaction 23.18 10.67 65 665810 18488 89944084
Muscular weakness 23.17 10.67 1791 664084 204875 89757697
Sinus tarsi syndrome 23.16 10.67 7 665868 6 89962566
Fracture reduction 23.16 10.67 7 665868 6 89962566
Wound secretion 23.14 10.67 85 665790 4905 89957667
Immobile 23.13 10.67 9 665866 6389 89956183
Coronavirus infection 23.06 10.67 6 665869 5509 89957063
Spinal pain 23.01 10.67 51 665824 15716 89946856
Anosmia 23.00 10.67 23 665852 9825 89952747
Amnesia 22.98 10.67 996 664879 107509 89855063
Drug dependence 22.96 10.67 124 665751 29203 89933369
Kidney transplant rejection 22.93 10.67 4 665871 4853 89957719
Cholecystitis chronic 22.89 10.67 23 665852 9803 89952769
Abdominal distension 22.86 10.67 758 665117 129843 89832729
Cervicobrachial syndrome 22.85 10.67 35 665840 1130 89961442
Angina pectoris 22.84 10.67 181 665694 38979 89923593
Injection site nodule 22.68 10.67 3 665872 4470 89958102
Swelling of eyelid 22.68 10.67 6 665869 5448 89957124
Rectal polyp 22.63 10.67 34 665841 1079 89961493
Sleep terror 22.62 10.67 3 665872 4461 89958111
Cerebrovascular disorder 22.61 10.67 58 665817 2748 89959824
Gingival abscess 22.61 10.67 33 665842 1020 89961552
Labyrinthitis 22.60 10.67 57 665818 2672 89959900
Periorbital swelling 22.55 10.67 4 665871 4794 89957778
Poor dental condition 22.48 10.67 23 665852 487 89962085
Goitre 22.47 10.67 104 665771 6663 89955909
Infusion site haemorrhage 22.41 10.67 6 665869 5405 89957167
Blood 25-hydroxycholecalciferol decreased 22.37 10.67 12 665863 87 89962485
Haemorrhage intracranial 22.16 10.67 49 665826 15113 89947459
Anxiety disorder 22.12 10.67 83 665792 4839 89957733
Osteitis deformans 22.10 10.67 16 665859 207 89962365
Denture wearer 22.10 10.67 16 665859 207 89962365
Internal haemorrhage 22.08 10.67 9 665866 6211 89956361
Oesophageal perforation 22.06 10.67 21 665854 406 89962166
Partial seizures 21.99 10.67 13 665862 7247 89955325
Hypernatraemia 21.83 10.67 22 665853 9365 89953207
Infusion site reaction 21.83 10.67 225 665650 18814 89943758
Galactorrhoea 21.73 10.67 4 665871 4668 89957904
Proctalgia 21.73 10.67 17 665858 8181 89954391
Hypertensive heart disease 21.72 10.67 55 665820 2585 89959987
Ventricular arrhythmia 21.67 10.67 3 665872 4318 89958254
Rhinitis perennial 21.67 10.67 9 665866 33 89962539
Bradypnoea 21.64 10.67 4 665871 4654 89957918
Transplant dysfunction 21.61 10.67 6 665869 5276 89957296
Salpingo-oophorectomy bilateral 21.53 10.67 21 665854 419 89962153
Toothache 21.49 10.67 254 665621 21976 89940596
Knee deformity 21.42 10.67 40 665835 1522 89961050
Product availability issue 21.40 10.67 14 665861 7390 89955182
Hypocholesterolaemia 21.33 10.67 99 665776 6350 89956222
Drug level below therapeutic 21.32 10.67 8 665867 5806 89956766
Dental pulp disorder 21.31 10.67 7 665868 10 89962562
Chromaturia 21.28 10.67 71 665804 19116 89943456
Skin swelling 21.25 10.67 11 665864 6603 89955969
Odontogenic cyst 21.22 10.67 8 665867 21 89962551
Cystitis haemorrhagic 21.22 10.67 7 665868 5506 89957066
Device deployment issue 21.19 10.67 5 665870 4904 89957668
Oesophageal discomfort 21.19 10.67 18 665857 298 89962274
Mixed incontinence 21.18 10.67 12 665863 98 89962474
Osteorrhagia 21.11 10.67 6 665869 3 89962569
Neutrophilia 21.10 10.67 8 665867 5770 89956802
Plasma cell myeloma recurrent 21.05 10.67 3 665872 4225 89958347
Erythema multiforme 21.00 10.67 36 665839 12210 89950362
Dementia Alzheimer's type 20.95 10.67 31 665844 970 89961602
Parosmia 20.93 10.67 13 665862 7056 89955516
Peritonitis bacterial 20.92 10.67 6 665869 5165 89957407
Sputum discoloured 20.91 10.67 78 665797 20313 89942259
Tongue oedema 20.86 10.67 7 665868 5447 89957125
Disturbance in social behaviour 20.79 10.67 3 665872 4185 89958387
Papule 20.70 10.67 17 665858 7985 89954587
Sudden death 20.67 10.67 30 665845 10879 89951693
Faeces soft 20.65 10.67 15 665860 7496 89955076
Blood creatinine abnormal 20.58 10.67 3 665872 4154 89958418
Skin infection 20.58 10.67 65 665810 17799 89944773
Substance abuse 20.57 10.67 7 665868 5399 89957173
Pulmonary pain 20.57 10.67 6 665869 5108 89957464
Groin pain 20.56 10.67 157 665718 12056 89950516
Feeling cold 20.49 10.67 118 665757 27347 89935225
Intestinal ischaemia 20.46 10.67 21 665854 8862 89953710
Hyperlactacidaemia 20.44 10.67 3 665872 4133 89958439
Ear discomfort 20.38 10.67 27 665848 10173 89952399
Granulocytopenia 20.28 10.67 11 665864 6430 89956142
Immune-mediated enterocolitis 20.23 10.67 5 665870 4752 89957820
Malpositioned teeth 20.21 10.67 8 665867 25 89962547
Uterine dilation and curettage 20.21 10.67 31 665844 1002 89961570
X-ray of pelvis and hip abnormal 20.19 10.67 7 665868 13 89962559
Bone sarcoma 20.19 10.67 7 665868 13 89962559
Poor quality sleep 20.12 10.67 103 665772 24590 89937982
Hypertransaminasaemia 20.10 10.67 55 665820 15770 89946802
Post procedural complication 20.08 10.67 72 665803 18970 89943602
Bone atrophy 20.06 10.67 10 665865 61 89962511
Adenoidectomy 20.03 10.67 13 665862 139 89962433
Osteogenesis imperfecta 19.99 10.67 29 665846 891 89961681
Dermatitis allergic 19.99 10.67 63 665812 17264 89945308
Palatal disorder 19.98 10.67 17 665858 282 89962290
Skin laceration 19.93 10.67 285 665590 25750 89936822
Incision site haematoma 19.92 10.67 11 665864 85 89962487
Catheter site pain 19.92 10.67 8 665867 5571 89957001
Hypoventilation 19.90 10.67 7 665868 5289 89957283
Ammonia increased 19.78 10.67 6 665869 4980 89957592
Neurological symptom 19.72 10.67 13 665862 6834 89955738
Cancer pain 19.71 10.67 3 665872 4022 89958550
Blood iron abnormal 19.68 10.67 3 665872 4017 89958555
Systemic candida 19.61 10.67 6 665869 4953 89957619
Apicectomy 19.60 10.67 5 665870 0 89962572
Chondroplasty 19.60 10.67 5 665870 0 89962572
Pulseless electrical activity 19.58 10.67 22 665853 8910 89953662
Laryngeal ulceration 19.54 10.67 7 665868 15 89962557
Wound complication 19.51 10.67 78 665797 4685 89957887
Tooth resorption 19.49 10.67 9 665866 45 89962527
Bone scan abnormal 19.49 10.67 20 665855 425 89962147
Cardiac disorder 19.47 10.67 297 665578 56575 89905997
Joint arthroplasty 19.41 10.67 63 665812 3414 89959158
Enterococcal infection 19.40 10.67 27 665848 9964 89952608
Pneumonia fungal 19.38 10.67 14 665861 7017 89955555
Hypophosphataemia 19.34 10.67 51 665824 14803 89947769
Urine abnormality 19.33 10.67 17 665858 7720 89954852
Pain in extremity 19.30 10.67 3673 662202 446856 89515716
Eye infection 19.28 10.67 48 665827 14206 89948366
Decreased activity 19.28 10.67 19 665856 8173 89954399
Systemic inflammatory response syndrome 19.27 10.67 12 665863 6504 89956068
Splenic granuloma 19.24 10.67 7 665868 16 89962556
White blood cells urine positive 19.17 10.67 12 665863 6486 89956086
Metabolic disorder 19.16 10.67 16 665859 7454 89955118
Red blood cell sedimentation rate abnormal 19.14 10.67 102 665773 24102 89938470
Dizziness postural 19.09 10.67 23 665852 9030 89953542
Heart rate abnormal 19.09 10.67 10 665865 5961 89956611
Hyperventilation 19.07 10.67 13 665862 6715 89955857
Pruritus genital 18.98 10.67 5 665870 4553 89958019
Colorectal cancer 18.84 10.67 3 665872 3890 89958682
Stasis dermatitis 18.83 10.67 29 665846 941 89961631
Cervical polyp 18.80 10.67 17 665858 307 89962265
Enterocolitis 18.77 10.67 30 665845 10460 89952112
Ankylosing spondylitis 18.74 10.67 43 665832 13090 89949482
Anal incontinence 18.73 10.67 59 665816 16171 89946401
Cataract cortical 18.73 10.67 9 665866 50 89962522
Serum ferritin increased 18.70 10.67 16 665859 7365 89955207
Large intestine benign neoplasm 18.51 10.67 12 665863 128 89962444
Bladder disorder 18.43 10.67 139 665736 10633 89951939
Hypersensitivity vasculitis 18.43 10.67 4 665871 4155 89958417
Hyperpyrexia 18.40 10.67 6 665869 4755 89957817
Heparin-induced thrombocytopenia 18.35 10.67 8 665867 5304 89957268
Acute coronary syndrome 18.35 10.67 32 665843 10781 89951791
Granuloma 18.34 10.67 92 665783 6093 89956479
Presbyopia 18.21 10.67 23 665852 617 89961955
Subdural haematoma 18.18 10.67 62 665813 16583 89945989
Drug level above therapeutic 18.17 10.67 10 665865 5799 89956773
Ageusia 18.17 10.67 59 665816 16017 89946555
Autoimmune hepatitis 18.15 10.67 30 665845 10321 89952251
Tooth impacted 18.14 10.67 17 665858 322 89962250
Panic reaction 18.14 10.67 6 665869 4711 89957861
Pulse absent 18.12 10.67 11 665864 6044 89956528
Dermatitis exfoliative 18.10 10.67 9 665866 5527 89957045
Bradykinesia 18.09 10.67 14 665861 6774 89955798
Blood pressure systolic decreased 18.06 10.67 25 665850 9245 89953327
Erysipelas 18.05 10.67 24 665851 9028 89953544
Tinnitus 18.04 10.67 216 665659 42886 89919686
Haemoglobin increased 18.02 10.67 17 665858 7464 89955108
Bronchial secretion retention 17.98 10.67 63 665812 3552 89959020
Gingival pain 17.92 10.67 127 665748 9525 89953047
Thinking abnormal 17.91 10.67 37 665838 11695 89950877
Protein urine present 17.87 10.67 15 665860 6969 89955603
Eye pain 17.86 10.67 223 665652 43945 89918627
Aphonia 17.85 10.67 40 665835 12279 89950293
Infusion site bruising 17.82 10.67 5 665870 4367 89958205
Acrochordon 17.82 10.67 36 665839 1453 89961119
Blood creatine increased 17.78 10.67 15 665860 6952 89955620
Cervical spinal stenosis 17.76 10.67 51 665824 2584 89959988
Neuralgia 17.72 10.67 147 665728 31353 89931219
Mouth cyst 17.72 10.67 10 665865 81 89962491
Diarrhoea haemorrhagic 17.69 10.67 32 665843 10631 89951941
Polyuria 17.69 10.67 29 665846 10011 89952561
Disability 17.69 10.67 408 665467 40337 89922235
Long QT syndrome 17.65 10.67 4 665871 4033 89958539
Frequent bowel movements 17.61 10.67 303 665572 56632 89905940
Platelet count increased 17.57 10.67 86 665789 20773 89941799
Cataract nuclear 17.55 10.67 30 665845 1064 89961508
Oesophageal injury 17.52 10.67 9 665866 59 89962513
Papilloedema 17.52 10.67 6 665869 4609 89957963
Renal cancer 17.51 10.67 11 665864 5934 89956638
Traumatic arthritis 17.49 10.67 8 665867 39 89962533
Activated partial thromboplastin time prolonged 17.46 10.67 19 665856 7806 89954766
Melanocytic naevus 17.44 10.67 80 665795 5106 89957466
Leukoencephalopathy 17.38 10.67 7 665868 4866 89957706
Peripheral ischaemia 17.37 10.67 10 665865 5657 89956915
Intestinal adhesion lysis 17.28 10.67 5 665870 3 89962569
Grip strength 17.26 10.67 119 665756 8846 89953726
Incision site cellulitis 17.16 10.67 13 665862 181 89962391
Osteosclerosis 17.11 10.67 70 665805 4250 89958322
Labile hypertension 17.08 10.67 20 665855 495 89962077
Rotator cuff repair 17.03 10.67 48 665827 2406 89960166
Fungal infection 17.03 10.67 216 665659 42445 89920127
Oesophagitis chemical 17.02 10.67 6 665869 12 89962560
Gastrointestinal toxicity 17.01 10.67 27 665848 9440 89953132
Sexual dysfunction 16.97 10.67 7 665868 4797 89957775
Intervertebral discitis 16.94 10.67 6 665869 4514 89958058
Periarthritis 16.93 10.67 55 665820 2982 89959590
Nasal dryness 16.91 10.67 10 665865 5573 89956999
Hepatic pain 16.89 10.67 3 665872 3592 89958980
Face injury 16.85 10.67 65 665810 3840 89958732
Trigger finger 16.83 10.67 79 665796 5091 89957481
Radiotherapy 16.83 10.67 27 665848 908 89961664
Meningitis aseptic 16.78 10.67 15 665860 6758 89955814
Hepatitis cholestatic 16.76 10.67 23 665852 8538 89954034
Choking 16.69 10.67 40 665835 11993 89950579
Liver function test increased 16.67 10.67 773 665102 84082 89878490
Oral discharge 16.66 10.67 12 665863 154 89962418
Ovarian cyst 16.64 10.67 68 665807 17250 89945322
Thermohypoaesthesia 16.61 10.67 11 665864 122 89962450
Left ventricular hypertrophy 16.56 10.67 89 665786 6055 89956517
Injection site irritation 16.55 10.67 12 665863 6003 89956569
Onychoclasis 16.47 10.67 18 665857 7381 89955191
Product administered at inappropriate site 16.46 10.67 5 665870 4146 89958426
Device extrusion 16.39 10.67 7 665868 28 89962544
Injection site haematoma 16.36 10.67 16 665859 6906 89955666
Splenomegaly 16.35 10.67 45 665830 12879 89949693
Hypercapnia 16.29 10.67 15 665860 6662 89955910
Ear congestion 16.27 10.67 59 665816 3383 89959189
Euglycaemic diabetic ketoacidosis 16.26 10.67 13 665862 6188 89956384
Localised oedema 16.22 10.67 13 665862 6181 89956391
Pigmentation disorder 16.20 10.67 12 665863 5937 89956635
Hypoxic-ischaemic encephalopathy 16.17 10.67 7 665868 4661 89957911
Secretion discharge 16.17 10.67 61 665814 15835 89946737
Blood pressure diastolic abnormal 16.16 10.67 83 665792 19798 89942774
Fear 16.14 10.67 65 665810 16557 89946015
Electroencephalogram abnormal 16.12 10.67 5 665870 4091 89958481
Haemoglobin abnormal 16.11 10.67 17 665858 7083 89955489
Breath odour 16.09 10.67 34 665841 1417 89961155
Wound drainage 16.06 10.67 26 665849 881 89961691
Inguinal hernia repair 16.04 10.67 9 665866 72 89962500
Enchondromatosis 16.02 10.67 11 665864 130 89962442
Skin hyperpigmentation 16.00 10.67 16 665859 6835 89955737
Benign neoplasm 15.95 10.67 28 665847 1015 89961557
Parathyroidectomy 15.90 10.67 16 665859 332 89962240
Intervertebral disc space narrowing 15.87 10.67 29 665846 1085 89961487
Pneumonia bacterial 15.84 10.67 45 665830 12745 89949827
Tendon sheath incision 15.84 10.67 9 665866 74 89962498
Chronic sinusitis 15.81 10.67 106 665769 23696 89938876
Uterovaginal prolapse 15.80 10.67 10 665865 102 89962470
Ear pruritus 15.76 10.67 16 665859 6787 89955785
Osteocalcin decreased 15.76 10.67 8 665867 51 89962521
General symptom 15.72 10.67 171 665704 14497 89948075
Rash morbilliform 15.71 10.67 5 665870 4024 89958548
Osteodystrophy 15.71 10.67 5 665870 6 89962566
Presbyoesophagus 15.71 10.67 5 665870 6 89962566
Fibrous dysplasia of bone 15.71 10.67 5 665870 6 89962566
General physical condition abnormal 15.70 10.67 9 665866 5102 89957470
Lipoma of breast 15.68 10.67 4 665871 0 89962572
Arthrotomy 15.68 10.67 4 665871 0 89962572
Uterine cervix atrophy 15.68 10.67 4 665871 0 89962572
Loss of anatomical alignment after fracture reduction 15.68 10.67 4 665871 0 89962572
Metatarsus primus varus 15.68 10.67 4 665871 0 89962572
Fracture debridement 15.68 10.67 4 665871 0 89962572
Impacted fracture 15.68 10.67 4 665871 0 89962572
Hepatitis toxic 15.68 10.67 4 665871 3721 89958851
Blood magnesium increased 15.67 10.67 3 665872 3405 89959167
White blood cell count increased 15.67 10.67 375 665500 66866 89895706
Tuberculosis 15.65 10.67 44 665831 12505 89950067
Pseudomonal sepsis 15.64 10.67 6 665869 4296 89958276
Calciphylaxis 15.47 10.67 3 665872 3373 89959199
Bowel movement irregularity 15.46 10.67 15 665860 6499 89956073
Respiratory rate decreased 15.43 10.67 5 665870 3978 89958594
Carotid endarterectomy 15.41 10.67 11 665864 139 89962433
Sinus bradycardia 15.40 10.67 68 665807 16884 89945688
Otitis externa 15.38 10.67 40 665835 1911 89960661
Eye discharge 15.37 10.67 23 665852 8235 89954337
Neurosensory hypoacusis 15.36 10.67 13 665862 214 89962358
Foot operation 15.32 10.67 116 665759 8885 89953687
Oesophageal ulcer haemorrhage 15.30 10.67 18 665857 448 89962124
Therapeutic reaction time decreased 15.26 10.67 4 665871 3654 89958918
Congestive cardiomyopathy 15.18 10.67 19 665856 7335 89955237
Pseudarthrosis 15.17 10.67 18 665857 452 89962120
Gingival swelling 15.17 10.67 75 665800 4938 89957634
Red blood cell count increased 15.16 10.67 4 665871 3639 89958933
Pulmonary function test decreased 15.16 10.67 7 665868 4487 89958085
Abnormal dreams 15.16 10.67 38 665837 11219 89951353
Clavicle fracture 15.15 10.67 63 665812 3853 89958719
Blood prolactin increased 15.13 10.67 4 665871 3633 89958939
Lenticular opacities 15.12 10.67 14 665861 261 89962311
Nephropathy 15.07 10.67 28 665847 9207 89953365
Injection site vesicles 15.03 10.67 6 665869 4194 89958378
Inability to afford medication 15.03 10.67 4 665871 3618 89958954
Sight disability 15.02 10.67 11 665864 145 89962427
Vascular headache 15.00 10.67 7 665868 36 89962536
Sluggishness 15.00 10.67 13 665862 5946 89956626
Dystrophic calcification 14.99 10.67 12 665863 182 89962390
Leukoplakia oral 14.99 10.67 14 665861 264 89962308
Urinary bladder polyp 14.91 10.67 8 665867 58 89962514
Cardiac dysfunction 14.88 10.67 4 665871 3593 89958979
Metatarsalgia 14.87 10.67 17 665858 410 89962162
Neuritis 14.82 10.67 31 665844 1283 89961289
Prothrombin time prolonged 14.76 10.67 31 665844 9741 89952831
Menopausal symptoms 14.76 10.67 53 665822 3025 89959547
Ileus 14.65 10.67 67 665808 16479 89946093
Listless 14.65 10.67 3 665872 3246 89959326
Periorbital oedema 14.63 10.67 17 665858 6782 89955790
Myositis 14.63 10.67 254 665621 23874 89938698
Myofascial pain syndrome 14.60 10.67 52 665823 2955 89959617
Ectopic pregnancy 14.60 10.67 3 665872 3238 89959334
Wrist deformity 14.58 10.67 3 665872 3235 89959337
Abdominal tenderness 14.58 10.67 29 665846 9295 89953277
Hypertonia 14.56 10.67 10 665865 5145 89957427
Sensory disturbance 14.51 10.67 61 665814 15352 89947220
Bone trimming 14.44 10.67 6 665869 22 89962550
Blood glucose abnormal 14.43 10.67 30 665845 9462 89953110
Urine output decreased 14.42 10.67 46 665829 12557 89950015
Eosinophil count decreased 14.41 10.67 3 665872 3209 89959363
Chondrocalcinosis pyrophosphate 14.39 10.67 27 665848 1031 89961541
Renal tubular disorder 14.38 10.67 3 665872 3204 89959368
Optic neuritis 14.37 10.67 31 665844 9647 89952925
Cholestatic liver injury 14.30 10.67 5 665870 3792 89958780
Paronychia 14.23 10.67 23 665852 7983 89954589
Antipsychotic drug level increased 14.19 10.67 5 665870 3774 89958798
Device defective 14.19 10.67 4 665871 3482 89959090
Thalassaemia beta 14.18 10.67 5 665870 10 89962562
Blood glucose fluctuation 14.17 10.67 10 665865 5073 89957499
Disease complication 14.15 10.67 5 665870 3767 89958805
Oesophageal haemorrhage 14.13 10.67 19 665856 543 89962029
Hepatic enzyme 14.12 10.67 77 665798 5267 89957305
Defaecation urgency 14.10 10.67 15 665860 6227 89956345
Respiratory rate increased 14.05 10.67 65 665810 15936 89946636
Endocarditis 14.04 10.67 19 665856 7094 89955478
Paradoxical drug reaction 14.01 10.67 13 665862 5753 89956819
Brain death 13.98 10.67 6 665869 4015 89958557
Drooling 13.97 10.67 8 665867 4538 89958034
Oropharyngeal discomfort 13.95 10.67 22 665853 7713 89954859
Gastrointestinal sounds abnormal 13.95 10.67 8 665867 4535 89958037
Injection site inflammation 13.94 10.67 8 665867 4533 89958039
Vertigo positional 13.89 10.67 55 665820 3289 89959283
Skin graft 13.87 10.67 21 665854 671 89961901
Borderline glaucoma 13.87 10.67 5 665870 11 89962561
Hormone replacement therapy 13.87 10.67 5 665870 11 89962561
Symphysiolysis 13.87 10.67 5 665870 11 89962561
Blood thyroid stimulating hormone increased 13.87 10.67 29 665846 9126 89953446
Vitreous degeneration 13.86 10.67 6 665869 25 89962547
Amylase increased 13.85 10.67 19 665856 7053 89955519
Repetitive strain injury 13.82 10.67 12 665863 205 89962367
Product distribution issue 13.75 10.67 5 665870 3700 89958872
Breast fibrosis 13.74 10.67 7 665868 45 89962527
Oxygen therapy 13.71 10.67 3 665872 3099 89959473
Hepatitis B reactivation 13.71 10.67 6 665869 3968 89958604
Salivary hypersecretion 13.60 10.67 29 665846 9063 89953509
Lacunar infarction 13.59 10.67 55 665820 3322 89959250
Vascular operation 13.58 10.67 10 665865 133 89962439
Urine calcium decreased 13.57 10.67 5 665870 12 89962560
Nasal disorder 13.56 10.67 54 665821 3238 89959334
Haematocrit increased 13.56 10.67 3 665872 3075 89959497
Acute psychosis 13.56 10.67 3 665872 3075 89959497
Application site erythema 13.55 10.67 11 665864 5197 89957375
Hepatitis fulminant 13.54 10.67 6 665869 3939 89958633
Colitis ulcerative 13.52 10.67 338 665537 59928 89902644
Salivary gland mass 13.50 10.67 9 665866 101 89962471
Bacterial sepsis 13.49 10.67 10 665865 4945 89957627
Aplasia pure red cell 13.48 10.67 11 665864 5183 89957389
Joint irrigation 13.47 10.67 4 665871 3 89962569
Areflexia 13.44 10.67 5 665870 3648 89958924
Infection susceptibility increased 13.43 10.67 6 665869 3920 89958652
Diffuse large B-cell lymphoma 13.42 10.67 27 665848 8618 89953954
Cardiac failure chronic 13.40 10.67 13 665862 5633 89956939
Autoimmune haemolytic anaemia 13.39 10.67 13 665862 5632 89956940
Subileus 13.38 10.67 5 665870 3639 89958933
Therapeutic product effect delayed 13.37 10.67 5 665870 3636 89958936
Cholangitis 13.37 10.67 20 665855 7162 89955410
Tachyarrhythmia 13.36 10.67 12 665863 5394 89957178
Gastrointestinal motility disorder 13.36 10.67 15 665860 6076 89956496
Hepatic fibrosis 13.33 10.67 7 665868 4168 89958404
Clostridium test positive 13.33 10.67 12 665863 5389 89957183
Cardiac tamponade 13.33 10.67 13 665862 5619 89956953
Hypopnoea 13.33 10.67 8 665867 4423 89958149
Retinal operation 13.32 10.67 6 665869 28 89962544
Immunosuppressant drug level increased 13.32 10.67 9 665866 4671 89957901
Mean cell haemoglobin concentration decreased 13.31 10.67 8 665867 4420 89958152
Apnoea 13.29 10.67 31 665844 9383 89953189
Dysmenorrhoea 13.28 10.67 9 665866 4663 89957909
Gouty arthritis 13.26 10.67 19 665856 577 89961995
Abdominal abscess 13.26 10.67 12 665863 5375 89957197
Joint surgery 13.24 10.67 17 665858 464 89962108
Electrocardiogram ST-T change 13.23 10.67 25 665850 960 89961612
Concomitant disease aggravated 13.20 10.67 42 665833 11476 89951096
Bone cyst 13.20 10.67 43 665832 2335 89960237
Immunosuppression 13.18 10.67 45 665830 12032 89950540
Lipoma 13.13 10.67 50 665825 2936 89959636
Forced expiratory volume decreased 13.07 10.67 14 665861 5794 89956778
Neutrophil count abnormal 13.07 10.67 7 665868 4121 89958451
Poliomyelitis 13.02 10.67 7 665868 51 89962521
Hypoglycaemic coma 13.00 10.67 3 665872 2987 89959585
Parathyroid gland operation 12.99 10.67 6 665869 30 89962542
Tooth dislocation 12.99 10.67 6 665869 30 89962542
Spinal decompression 12.97 10.67 14 665861 316 89962256
Intervertebral disc displacement 12.93 10.67 17 665858 475 89962097
Multiple fractures 12.93 10.67 117 665758 9445 89953127
Increased tendency to bruise 12.92 10.67 139 665736 11751 89950821
Bladder prolapse 12.90 10.67 40 665835 2115 89960457
Blood culture positive 12.84 10.67 11 665864 5061 89957511
Oxygen consumption increased 12.83 10.67 9 665866 4580 89957992
Bone infarction 12.82 10.67 16 665859 424 89962148
N-terminal prohormone brain natriuretic peptide increased 12.82 10.67 3 665872 2959 89959613
Eye movement disorder 12.80 10.67 16 665859 6182 89956390
Maternal exposure before pregnancy 12.78 10.67 41 665834 11172 89951400
Pleural thickening 12.72 10.67 4 665871 3244 89959328
Oophorectomy bilateral 12.66 10.67 9 665866 113 89962459
Dyspnoea at rest 12.62 10.67 10 665865 4781 89957791
Breast hyperplasia 12.59 10.67 14 665861 327 89962245
Eustachian tube disorder 12.59 10.67 9 665866 114 89962458
Calculus urinary 12.56 10.67 34 665841 1664 89960908
Cystocele repair 12.55 10.67 5 665870 16 89962556
Oxygen saturation abnormal 12.54 10.67 8 665867 4280 89958292
Neurological decompensation 12.53 10.67 5 665870 3496 89959076
Spinal deformity 12.53 10.67 28 665847 1213 89961359
Performance status decreased 12.50 10.67 8 665867 4272 89958300
Osteochondroma 12.48 10.67 4 665871 5 89962567
Cutaneous vasculitis 12.47 10.67 21 665854 7172 89955400
Benign breast neoplasm 12.46 10.67 29 665846 1291 89961281
Methaemoglobinaemia 12.43 10.67 7 665868 4008 89958564
Skin cancer 12.43 10.67 153 665722 13366 89949206
Bursa disorder 12.42 10.67 11 665864 193 89962379
Hepatic lesion 12.41 10.67 14 665861 5659 89956913
Metabolic encephalopathy 12.38 10.67 19 665856 6733 89955839
Device intolerance 12.37 10.67 8 665867 85 89962487
Poor personal hygiene 12.36 10.67 15 665860 386 89962186
Potentiating drug interaction 12.35 10.67 14 665861 5648 89956924
Product physical issue 12.35 10.67 14 665861 5646 89956926
Blood pressure systolic abnormal 12.32 10.67 88 665787 19390 89943182
Reflux laryngitis 12.32 10.67 12 665863 239 89962333
Application site pruritus 12.32 10.67 8 665867 4239 89958333
Persistent depressive disorder 12.29 10.67 28 665847 1229 89961343
Pharyngeal paraesthesia 12.27 10.67 4 665871 3170 89959402
Application site pain 12.24 10.67 10 665865 4710 89957862
Autonomic nervous system imbalance 12.23 10.67 5 665870 3445 89959127
Juvenile idiopathic arthritis 12.22 10.67 7 665868 3970 89958602
Gingival ulceration 12.21 10.67 25 665850 1019 89961553
Dyschezia 12.21 10.67 3 665872 2862 89959710
Carcinoid tumour pulmonary 12.20 10.67 17 665858 503 89962069
Blood pressure diastolic increased 12.20 10.67 51 665824 12855 89949717
Anaphylactoid reaction 12.18 10.67 9 665866 4459 89958113
Pneumatosis intestinalis 12.16 10.67 5 665870 3432 89959140
Portal hypertension 12.15 10.67 10 665865 4691 89957881
Left ventricular failure 12.14 10.67 19 665856 6681 89955891
Insulin-requiring type 2 diabetes mellitus 12.13 10.67 8 665867 88 89962484
Actinic elastosis 12.11 10.67 6 665869 36 89962536
Stomatitis necrotising 12.08 10.67 9 665866 122 89962450
Lung transplant 12.07 10.67 6 665869 3686 89958886
Transfusion 12.06 10.67 77 665798 17411 89945161
Dysplastic naevus syndrome 12.06 10.67 4 665871 6 89962566
Enuresis 12.02 10.67 5 665870 3409 89959163
Lower gastrointestinal haemorrhage 11.99 10.67 30 665845 8862 89953710
Lymphocyte percentage decreased 11.98 10.67 4 665871 3123 89959449
Hypereosinophilic syndrome 11.97 10.67 14 665861 346 89962226
Eye disorder 11.95 10.67 136 665739 27254 89935318
Breast cancer 11.93 10.67 302 665573 53459 89909113
Ventricular hypokinesia 11.88 10.67 13 665862 5328 89957244
Rectal haemorrhage 11.85 10.67 492 665383 82252 89880320
Orthopnoea 11.81 10.67 20 665855 6815 89955757
Skin weeping 11.80 10.67 3 665872 2797 89959775
Respiratory tract infection viral 11.80 10.67 4 665871 3092 89959480
Eye inflammation 11.78 10.67 25 665850 7826 89954746
Abortion 11.77 10.67 3 665872 2792 89959780
Spinal corpectomy 11.76 10.67 3 665872 0 89962572
Alcohol detoxification 11.76 10.67 3 665872 0 89962572
Urethral intrinsic sphincter deficiency 11.76 10.67 3 665872 0 89962572
Traction 11.76 10.67 3 665872 0 89962572
Mastoid abscess 11.76 10.67 3 665872 0 89962572
Traumatic arthropathy 11.76 10.67 3 665872 0 89962572
Tarsal tunnel decompression 11.76 10.67 3 665872 0 89962572
Erythroplasia 11.76 10.67 3 665872 0 89962572
Dental examination abnormal 11.76 10.67 3 665872 0 89962572
Femoral hernia repair 11.76 10.67 3 665872 0 89962572
Epidural fibrosis 11.76 10.67 3 665872 0 89962572
Reaction to food additive 11.76 10.67 3 665872 0 89962572
Intestinal mucosal tear 11.76 10.67 3 665872 0 89962572
Prolapse repair 11.76 10.67 3 665872 0 89962572
Articular disc disorder 11.76 10.67 3 665872 0 89962572
Benign neoplasm of spinal cord 11.76 10.67 3 665872 0 89962572
Deafness traumatic 11.76 10.67 3 665872 0 89962572
Pyelonephritis 11.76 10.67 100 665775 21216 89941356
Central venous catheterisation 11.71 10.67 3 665872 2783 89959789
Lithotripsy 11.70 10.67 5 665870 20 89962552
Sialoadenitis 11.70 10.67 39 665836 2143 89960429
Vascular skin disorder 11.69 10.67 4 665871 7 89962565
Hyperuricosuria 11.69 10.67 4 665871 7 89962565
Vascular insufficiency 11.66 10.67 12 665863 256 89962316
Parathyroid tumour benign 11.65 10.67 23 665852 913 89961659
Fungaemia 11.64 10.67 5 665870 3345 89959227
Cerebellar syndrome 11.63 10.67 7 665868 3865 89958707
Failure to thrive 11.63 10.67 28 665847 8383 89954189
Ear pain 11.62 10.67 527 665348 57175 89905397
Scar 11.56 10.67 66 665809 15329 89947243
Platelet count abnormal 11.48 10.67 9 665866 4326 89958246
Streptococcal sepsis 11.46 10.67 6 665869 3578 89958994
Device related sepsis 11.42 10.67 11 665864 4782 89957790
Appetite disorder 11.41 10.67 32 665843 9101 89953471
Formication 11.41 10.67 11 665864 4780 89957792
Tooth infection 11.40 10.67 210 665665 19960 89942612
Rhinitis allergic 11.39 10.67 180 665695 16605 89945967
Culture urine positive 11.37 10.67 7 665868 3818 89958754
Pyogenic granuloma 11.35 10.67 13 665862 314 89962258
Tearfulness 11.35 10.67 11 665864 4769 89957803
Foreign body aspiration 11.34 10.67 11 665864 218 89962354
Arthrofibrosis 11.33 10.67 5 665870 22 89962550
Laboratory test abnormal 11.31 10.67 228 665647 41626 89920946
Streptococcal infection 11.30 10.67 23 665852 7310 89955262
Anal fistula 11.30 10.67 9 665866 4292 89958280
Facial bones fracture 11.29 10.67 56 665819 3691 89958881
Oral mucosal blistering 11.29 10.67 21 665854 6903 89955669
JC virus infection 11.29 10.67 3 665872 2716 89959856
Ovarian cystectomy 11.27 10.67 10 665865 176 89962396
Trigeminal neuralgia 11.24 10.67 60 665815 4071 89958501
Rectocele repair 11.24 10.67 6 665869 43 89962529
Foreign body 11.16 10.67 42 665833 2452 89960120
Sebaceous hyperplasia 11.16 10.67 5 665870 23 89962549
Antibody test positive 11.15 10.67 4 665871 2985 89959587
Sputum culture 11.13 10.67 13 665862 321 89962251
Hip deformity 11.11 10.67 12 665863 271 89962301
Drug abuser 11.11 10.67 3 665872 2687 89959885
Hypophosphatasia 11.09 10.67 7 665868 71 89962501
Atelectasis 11.09 10.67 246 665629 24163 89938409
Electrocardiogram ST segment elevation 11.07 10.67 8 665867 4008 89958564
Eye haemorrhage 11.06 10.67 38 665837 10142 89952430
Injection site reaction 11.06 10.67 558 665317 91522 89871050
Spinal claudication 11.04 10.67 10 665865 181 89962391
Poor quality product administered 11.02 10.67 8 665867 4000 89958572
Laryngeal neoplasm 11.02 10.67 6 665869 45 89962527
Breast cyst excision 11.01 10.67 7 665868 72 89962500
Bronchitis chronic 11 10.67 66 665809 4677 89957895
Muscle tightness 10.98 10.67 56 665819 13383 89949189
Macule 10.98 10.67 3 665872 2666 89959906
Breast operation 10.97 10.67 18 665857 617 89961955
Hair colour changes 10.95 10.67 6 665869 3488 89959084
Hormone level abnormal 10.94 10.67 46 665829 2827 89959745
Device infusion issue 10.93 10.67 3 665872 2659 89959913
Gastroenteritis 10.93 10.67 150 665725 29079 89933493
Metastases to spine 10.92 10.67 7 665868 3736 89958836
Infusion site infection 10.92 10.67 3 665872 2657 89959915
Red blood cells urine positive 10.92 10.67 5 665870 3220 89959352
Inadequate analgesia 10.91 10.67 5 665870 3219 89959353
Brain natriuretic peptide increased 10.91 10.67 17 665858 5988 89956584
Large intestine infection 10.90 10.67 3 665872 2654 89959918
Ocular icterus 10.87 10.67 8 665867 3972 89958600
Atrial tachycardia 10.84 10.67 17 665858 5973 89956599
Product administration error 10.84 10.67 133 665742 26290 89936282
Intestinal haemorrhage 10.83 10.67 10 665865 4437 89958135
Feeling of despair 10.80 10.67 5 665870 3199 89959373
Muscle contractions involuntary 10.78 10.67 4 665871 2924 89959648
Dental discomfort 10.76 10.67 16 665859 503 89962069
Modified radical mastectomy 10.75 10.67 4 665871 10 89962562
Pancreatic carcinoma 10.73 10.67 29 665846 8348 89954224

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis 407.43 11.12 245 49355 15620 42556115
Osteonecrosis of jaw 354.32 11.12 240 49360 18809 42552926
Pulmonary vasculitis 269.38 11.12 136 49464 6130 42565605
Eosinophilic granulomatosis with polyangiitis 268.38 11.12 151 49449 8487 42563248
Respiratory symptom 258.23 11.12 161 49439 10945 42560790
Femur fracture 255.69 11.12 153 49447 9659 42562076
Neuritis 224.34 11.12 120 49480 6100 42565635
Obstructive airways disorder 201.24 11.12 192 49408 24567 42547168
Atypical femur fracture 194.62 11.12 51 49549 307 42571428
Total lung capacity abnormal 189.71 11.12 96 49504 4347 42567388
Asthma 180.80 11.12 287 49313 62027 42509708
Low turnover osteopathy 180.61 11.12 38 49562 66 42571669
Pulmonary fibrosis 178.26 11.12 186 49414 26495 42545240
Neurological symptom 171.85 11.12 120 49480 9871 42561864
Spirometry abnormal 157.25 11.12 89 49511 5057 42566678
Toxicity to various agents 149.40 11.12 41 49559 229095 42342640
Nodule 147.59 11.12 120 49480 12414 42559321
Forced expiratory volume decreased 146.28 11.12 98 49502 7532 42564203
Pulmonary alveolar haemorrhage 143.96 11.12 127 49473 14689 42557046
Conjunctivitis allergic 143.25 11.12 88 49512 5823 42565912
Vasculitis 142.59 11.12 139 49461 18255 42553480
Mite allergy 134.87 11.12 80 49520 4966 42566769
Mycotic allergy 134.55 11.12 79 49521 4812 42566923
Osteoporosis 133.43 11.12 122 49478 14784 42556951
Dust allergy 128.24 11.12 79 49521 5253 42566482
Osteomyelitis 121.63 11.12 127 49473 18096 42553639
Antineutrophil cytoplasmic antibody positive 121.38 11.12 71 49529 4294 42567441
Impaired healing 117.70 11.12 121 49479 16932 42554803
Febrile neutropenia 114.13 11.12 37 49563 185666 42386069
Atypical fracture 113.88 11.12 29 49571 153 42571582
Intramedullary rod insertion 112.08 11.12 21 49579 11 42571724
Bone density decreased 110.05 11.12 53 49547 2153 42569582
Sleep disorder due to a general medical condition 110.03 11.12 118 49482 17335 42554400
Normochromic normocytic anaemia 109.57 11.12 88 49512 8943 42562792
Rheumatoid arthritis 104.95 11.12 182 49418 42258 42529477
Drug ineffective 104.15 11.12 381 49219 629816 41941919
Open reduction of fracture 102.85 11.12 24 49576 81 42571654
Dental caries 101.70 11.12 66 49534 4806 42566929
Full blood count abnormal 95.53 11.12 144 49456 29732 42542003
Drug abuse 95.06 11.12 7 49593 104764 42466971
Completed suicide 95.04 11.12 4 49596 96461 42475274
Hypothyroidism 93.29 11.12 148 49452 31936 42539799
Wheezing 91.46 11.12 199 49401 54582 42517153
Blood immunoglobulin E increased 90.48 11.12 55 49545 3570 42568165
Productive cough 88.01 11.12 189 49411 51378 42520357
Central nervous system mass 87.23 11.12 34 49566 817 42570918
Wall motion score index abnormal 87.07 11.12 34 49566 821 42570914
Airway remodelling 85.38 11.12 34 49566 866 42570869
Arteriosclerosis 85.33 11.12 105 49495 17884 42553851
Atopy 82.75 11.12 34 49566 941 42570794
Stress fracture 81.46 11.12 34 49566 980 42570755
Cardiac septal defect 79.86 11.12 33 49567 927 42570808
Neutropenia 78.45 11.12 70 49530 199361 42372374
Capillaritis 77.58 11.12 42 49558 2186 42569549
Off label use 76.57 11.12 434 49166 637901 41933834
Eosinophilic myocarditis 74.64 11.12 35 49565 1338 42570397
Microangiopathy 73.72 11.12 37 49563 1645 42570090
Loss of personal independence in daily activities 72.07 11.12 171 49429 49645 42522090
Alanine aminotransferase abnormal 68.25 11.12 52 49548 4892 42566843
Nasal polyps 67.96 11.12 47 49553 3804 42567931
Therapeutic product effect incomplete 67.85 11.12 209 49391 70730 42501005
Arteriosclerosis coronary artery 66.91 11.12 95 49505 18582 42553153
Chronic sinusitis 66.05 11.12 44 49556 3348 42568387
Osteonecrosis of external auditory canal 63.97 11.12 15 49585 52 42571683
Tooth disorder 63.50 11.12 74 49526 11905 42559830
Blood parathyroid hormone decreased 62.92 11.12 33 49567 1610 42570125
Haemoptysis 62.00 11.12 154 49446 46013 42525722
Periodontal disease 59.81 11.12 26 49574 830 42570905
Tibia fracture 59.61 11.12 33 49567 1795 42569940
Osteoarthritis 58.15 11.12 103 49497 24302 42547433
Tooth loss 58.02 11.12 44 49556 4110 42567625
Disease progression 56.97 11.12 50 49550 143606 42428129
Exposed bone in jaw 55.45 11.12 30 49570 1559 42570176
Thrombocytopenia 55.24 11.12 85 49515 190194 42381541
Hypophosphataemic osteomalacia 54.39 11.12 16 49584 155 42571580
Osteopenia 53.49 11.12 50 49550 6228 42565507
Tooth fracture 53.38 11.12 42 49558 4142 42567593
Lung disorder 52.30 11.12 148 49452 47775 42523960
Exostosis of jaw 52.24 11.12 14 49586 93 42571642
Anxiety 51.46 11.12 273 49327 118287 42453448
Jaw disorder 49.76 11.12 31 49569 2102 42569633
Arthropathy 48.78 11.12 107 49493 29490 42542245
Joint ankylosis 48.54 11.12 28 49572 1649 42570086
Red blood cell sedimentation rate 48.05 11.12 24 49576 1056 42570679
Jaw fracture 47.97 11.12 24 49576 1060 42570675
Intentional overdose 47.93 11.12 3 49597 51453 42520282
Vomiting 47.01 11.12 176 49424 289547 42282188
Bone cyst 46.28 11.12 27 49573 1624 42570111
Granuloma skin 46.14 11.12 24 49576 1151 42570584
Hypercalciuria 45.66 11.12 17 49583 359 42571376
Craniotabes 45.59 11.12 9 49591 9 42571726
Death 45.32 11.12 342 49258 470843 42100892
Spinal compression fracture 44.38 11.12 49 49551 7434 42564301
Gastrooesophageal reflux disease 44.29 11.12 134 49466 44889 42526846
Eosinophilic pneumonia 43.82 11.12 40 49560 4834 42566901
Eosinophil count decreased 43.70 11.12 35 49565 3541 42568194
Arthralgia 43.31 11.12 396 49204 204842 42366893
Fracture nonunion 43.12 11.12 14 49586 193 42571542
Sleep apnoea syndrome 42.50 11.12 84 49516 21524 42550211
C-reactive protein abnormal 42.22 11.12 53 49547 9208 42562527
Synovitis 41.42 11.12 69 49531 15498 42556237
Fall 40.97 11.12 435 49165 234085 42337650
Hypotension 40.81 11.12 158 49442 257473 42314262
Anti-cyclic citrullinated peptide antibody positive 40.15 11.12 26 49574 1886 42569849
Acute kidney injury 40.01 11.12 257 49343 367080 42204655
Internal fixation of fracture 39.05 11.12 11 49589 90 42571645
Pyrexia 38.80 11.12 284 49316 393758 42177977
Anaemia postoperative 38.64 11.12 17 49583 559 42571176
Nausea 38.59 11.12 287 49313 396512 42175223
Spinal fracture 37.82 11.12 50 49550 9140 42562595
Skin injury 36.94 11.12 28 49572 2613 42569122
Pain in extremity 36.67 11.12 300 49300 150304 42421431
Rheumatoid nodule 35.94 11.12 29 49571 2966 42568769
Cataract 35.84 11.12 97 49503 30507 42541228
Leukopenia 34.78 11.12 22 49578 74724 42497011
Dental fistula 34.08 11.12 10 49590 96 42571639
Osteolysis 33.40 11.12 30 49570 3550 42568185
Intervertebral disc degeneration 33.32 11.12 42 49558 7325 42564410
Bone fissure 32.53 11.12 10 49590 114 42571621
COVID-19 32.47 11.12 53 49547 115895 42455840
Panniculitis 32.46 11.12 24 49576 2157 42569578
Oral infection 32.15 11.12 25 49575 2423 42569312
Tendonitis 32.05 11.12 48 49552 9846 42561889
Pain in jaw 31.74 11.12 59 49541 14443 42557292
Abscess jaw 31.64 11.12 16 49584 723 42571012
Nerve degeneration 31.38 11.12 11 49589 194 42571541
Hypophosphatasia 31.29 11.12 8 49592 43 42571692
Tooth abscess 31.28 11.12 39 49561 6729 42565006
Hip fracture 30.99 11.12 56 49544 13416 42558319
Rib fracture 30.89 11.12 63 49537 16508 42555227
Temporomandibular joint syndrome 30.75 11.12 17 49583 922 42570813
Periprosthetic fracture 30.72 11.12 11 49589 207 42571528
Coma 30.58 11.12 12 49588 53542 42518193
Resorption bone increased 30.57 11.12 12 49588 294 42571441
Intentional product misuse 30.52 11.12 17 49583 61883 42509852
Exostosis 30.20 11.12 35 49565 5596 42566139
Fracture 30.18 11.12 42 49558 8061 42563674
Medical device removal 29.66 11.12 10 49590 156 42571579
Lactic acidosis 29.62 11.12 8 49592 45253 42526482
Cytokine release syndrome 28.89 11.12 8 49592 44519 42527216
Bone disorder 28.80 11.12 37 49563 6576 42565159
Bone metabolism disorder 28.35 11.12 11 49589 261 42571474
Hand deformity 28.30 11.12 28 49572 3740 42567995
Bone erosion 28.15 11.12 30 49570 4373 42567362
Spinal osteoarthritis 27.94 11.12 42 49558 8644 42563091
Periodontitis 27.79 11.12 22 49578 2189 42569546
Ventricular hypokinesia 27.63 11.12 37 49563 6847 42564888
Foot fracture 27.53 11.12 35 49565 6156 42565579
Nocturia 27.42 11.12 50 49550 12062 42559673
Cardiac arrest 27 11.12 54 49546 109266 42462469
Lumbar vertebral fracture 26.47 11.12 25 49575 3154 42568581
Drug interaction 25.95 11.12 193 49407 266806 42304929
Ankle fracture 25.69 11.12 30 49570 4836 42566899
Infusion related reaction 25.66 11.12 139 49461 60667 42511068
Basal cell carcinoma 25.57 11.12 71 49529 22662 42549073
Drug ineffective for unapproved indication 25.30 11.12 11 49589 46152 42525583
Suicide attempt 25.24 11.12 11 49589 46089 42525646
Dental necrosis 25.12 11.12 6 49594 23 42571712
Eosinophil count increased 25.09 11.12 45 49555 10718 42561017
Fibula fracture 24.96 11.12 16 49584 1140 42570595
Foetal exposure during pregnancy 24.80 11.12 12 49588 47299 42524436
Pain 24.66 11.12 411 49189 244437 42327298
Red blood cell sedimentation rate abnormal 24.28 11.12 26 49574 3810 42567925
Lumbar spinal stenosis 23.58 11.12 23 49577 3020 42568715
Psoriatic arthropathy 23.33 11.12 73 49527 24894 42546841
Tongue disorder 23.26 11.12 30 49570 5353 42566382
Tenosynovitis 23.22 11.12 28 49572 4667 42567068
Renal mass 23.21 11.12 19 49581 1983 42569752
Right atrial hypertrophy 23.20 11.12 13 49587 724 42571011
Tooth extraction 22.84 11.12 30 49570 5450 42566285
Kyphosis 22.77 11.12 16 49584 1328 42570407
Polymyalgia rheumatica 22.73 11.12 20 49580 2303 42569432
Gingival disorder 22.71 11.12 17 49583 1557 42570178
Thoracic vertebral fracture 22.55 11.12 20 49580 2328 42569407
Rhabdomyolysis 22.46 11.12 35 49565 77984 42493751
Hepatic fibrosis 22.39 11.12 28 49572 4844 42566891
Product use in unapproved indication 22.15 11.12 125 49475 184331 42387404
Alveolar osteitis 22.15 11.12 7 49593 88 42571647
Bone loss 22.07 11.12 12 49588 630 42571105
Embolic stroke 21.64 11.12 28 49572 5012 42566723
Prostate cancer 21.57 11.12 106 49494 44537 42527198
Oesophageal ulcer 21.23 11.12 24 49576 3735 42568000
Musculoskeletal disorder 21.21 11.12 32 49568 6606 42565129
Malignant neoplasm progression 20.87 11.12 61 49539 108339 42463396
Femoral neck fracture 20.65 11.12 25 49575 4184 42567551
Pathological fracture 20.56 11.12 28 49572 5265 42566470
Fracture delayed union 20.50 11.12 6 49594 57 42571678
Therapeutic product effect decreased 20.40 11.12 95 49505 39055 42532680
Viral infection 20.33 11.12 65 49535 22418 42549317
Ventricular fibrillation 20.33 11.12 5 49595 30118 42541617
Blood pressure diastolic abnormal 20.24 11.12 30 49570 6098 42565637
Device breakage 20.11 11.12 23 49577 3626 42568109
Aortic valve stenosis 19.99 11.12 21 49579 3011 42568724
Acetabulum fracture 19.98 11.12 10 49590 442 42571293
Diverticulitis 19.83 11.12 65 49535 22708 42549027
Sequestrectomy 19.69 11.12 8 49592 215 42571520
Gastritis 19.66 11.12 67 49533 23880 42547855
Skin ulcer 19.61 11.12 70 49530 25531 42546204
Somnolence 19.55 11.12 91 49509 141014 42430721
Scoliosis 19.46 11.12 21 49579 3105 42568630
Pneumonectomy 19.31 11.12 6 49594 71 42571664
Blood pressure fluctuation 19.28 11.12 72 49528 26836 42544899
Oral cavity fistula 19.20 11.12 7 49593 139 42571596
Nasal septum deviation 18.88 11.12 14 49586 1264 42570471
Sedation 18.81 11.12 6 49594 30469 42541266
Cardiogenic shock 18.74 11.12 9 49591 35631 42536104
Herpes zoster 18.56 11.12 92 49508 38785 42532950
Gingivitis 18.53 11.12 23 49577 3950 42567785
Pelvic cyst 18.43 11.12 5 49595 35 42571700
Bronchial secretion retention 18.10 11.12 15 49585 1592 42570143
Diarrhoea 18.04 11.12 404 49196 460445 42111290
Rheumatoid lung 18.02 11.12 12 49588 912 42570823
Renal failure 18.01 11.12 96 49504 143630 42428105
Enthesopathy 17.94 11.12 25 49575 4803 42566932
Clumsiness 17.88 11.12 16 49584 1884 42569851
Essential thrombocythaemia 17.85 11.12 7 49593 171 42571564
Overdose 17.64 11.12 63 49537 105201 42466534
Thrombosis 17.47 11.12 138 49462 68373 42503362
Anaemia 17.36 11.12 226 49374 280052 42291683
Renal cyst 17.34 11.12 37 49563 10002 42561733
Dental prosthesis placement 17.27 11.12 3 49597 0 42571735
Corneal abrasion 17.23 11.12 8 49592 299 42571436
Hyperkalaemia 17.20 11.12 43 49557 80415 42491320
Body temperature decreased 17.19 11.12 46 49554 14367 42557368
Bursitis 17.04 11.12 28 49572 6216 42565519
Skin necrosis 16.81 11.12 28 49572 6286 42565449
Gastrointestinal infection 16.76 11.12 29 49571 6714 42565021
Lacrimation increased 16.60 11.12 40 49560 11718 42560017
Oesophagitis 16.54 11.12 47 49553 15200 42556535
Mobility decreased 16.47 11.12 83 49517 35223 42536512
Rash maculo-papular 16.16 11.12 12 49588 37491 42534244
Osteomalacia 16.10 11.12 11 49589 873 42570862
Drug resistance 16.04 11.12 10 49590 34238 42537497
Bronchial wall thickening 15.96 11.12 13 49587 1347 42570388
Extraskeletal ossification 15.96 11.12 5 49595 61 42571674
Neurotoxicity 15.81 11.12 4 49596 23647 42548088
Poor dental condition 15.56 11.12 7 49593 243 42571492
Blood pressure systolic increased 15.41 11.12 69 49531 27899 42543836
Osteitis 15.35 11.12 14 49586 1690 42570045
Hepatic cytolysis 15.35 11.12 6 49594 26838 42544897
Hiatus hernia 15.31 11.12 32 49568 8528 42563207
Nightmare 15.31 11.12 5 49595 25007 42546728
Product dose omission issue 15.25 11.12 111 49489 154254 42417481
Joint dislocation 15.25 11.12 22 49578 4365 42567370
Loose tooth 15.20 11.12 12 49588 1189 42570546
Renal neoplasm 15.04 11.12 13 49587 1462 42570273
Liver function test abnormal 15.00 11.12 76 49524 32315 42539420
Tinea pedis 14.98 11.12 15 49585 2033 42569702
Ascites 14.86 11.12 27 49573 56651 42515084
Compression fracture 14.85 11.12 20 49580 3722 42568013
Calcium deficiency 14.85 11.12 7 49593 271 42571464
Pelvic fracture 14.84 11.12 17 49583 2684 42569051
White blood cell count decreased 14.81 11.12 72 49528 110324 42461411
Benign prostatic hyperplasia 14.81 11.12 56 49544 20996 42550739
Cardiac failure 14.74 11.12 69 49531 106787 42464948
Dermal sinus 14.74 11.12 3 49597 4 42571731
Palmar-plantar erythrodysaesthesia syndrome 14.72 11.12 3 49597 20579 42551156
Device failure 14.63 11.12 17 49583 2726 42569009
Hyperhidrosis 14.62 11.12 55 49545 90457 42481278
Right ventricular hypertrophy 14.47 11.12 13 49587 1539 42570196
Cardiac ablation 14.45 11.12 12 49588 1278 42570457
Suicidal ideation 14.44 11.12 21 49579 48140 42523595
Tumour lysis syndrome 14.41 11.12 4 49596 22227 42549508
Bone infarction 14.40 11.12 7 49593 290 42571445
Hypoxia 14.34 11.12 134 49466 69652 42502083
Therapy partial responder 14.15 11.12 3 49597 20018 42551717
Hyperlipidaemia 14.12 11.12 56 49544 21460 42550275
Rash 14.11 11.12 232 49368 276722 42295013
Carpal tunnel syndrome 14 11.12 24 49576 5515 42566220
Lip neoplasm 13.98 11.12 3 49597 6 42571729
Restrictive pulmonary disease 13.87 11.12 12 49588 1351 42570384
Mouth swelling 13.82 11.12 15 49585 2231 42569504
Oral disorder 13.71 11.12 22 49578 4790 42566945
Langerhans' cell histiocytosis 13.58 11.12 4 49596 39 42571696
Erythrasma 13.58 11.12 4 49596 39 42571696
Groin pain 13.56 11.12 25 49575 6079 42565656
Bone abscess 13.55 11.12 7 49593 331 42571404
Vertebroplasty 13.48 11.12 4 49596 40 42571695
Encephalopathy 13.43 11.12 17 49583 41316 42530419
Abscess oral 13.40 11.12 8 49592 502 42571233
Dental plaque 13.38 11.12 3 49597 8 42571727
Mycobacterium chelonae infection 13.28 11.12 11 49589 1167 42570568
Loose body in joint 13.22 11.12 4 49596 43 42571692
Myelomalacia 13.15 11.12 5 49595 112 42571623
Limb asymmetry 13.15 11.12 5 49595 112 42571623
Giant cell arteritis 13.12 11.12 11 49589 1187 42570548
Idiopathic pulmonary fibrosis 13.05 11.12 21 49579 4583 42567152
C-reactive protein increased 13.04 11.12 122 49478 63438 42508297
Cellulitis 13.03 11.12 119 49481 61466 42510269
Small cell lung cancer 12.91 11.12 14 49586 2081 42569654
Feeling abnormal 12.90 11.12 40 49560 69746 42501989
Respiratory rate increased 12.89 11.12 35 49565 11027 42560708
Penile erythema 12.83 11.12 6 49594 228 42571507
Myelosuppression 12.78 11.12 17 49583 40444 42531291
Lung neoplasm 12.76 11.12 21 49579 4667 42567068
Renal disorder 12.73 11.12 67 49533 28913 42542822
Dry skin 12.69 11.12 23 49577 48315 42523420
Enterocolitis bacterial 12.62 11.12 7 49593 382 42571353
Multiple organ dysfunction syndrome 12.61 11.12 64 49536 96971 42474764
Oral pustule 12.59 11.12 6 49594 238 42571497
Bronchitis 12.54 11.12 96 49504 47105 42524630
Phlebosclerosis 12.53 11.12 5 49595 128 42571607
Pruritus 12.50 11.12 150 49450 188621 42383114
Fracture malunion 12.46 11.12 3 49597 12 42571723
Abdominal rigidity 12.45 11.12 12 49588 1553 42570182
Electrocardiogram QT prolonged 12.42 11.12 23 49577 47922 42523813
Laryngeal ulceration 12.39 11.12 5 49595 132 42571603
Eosinophilic bronchitis 12.31 11.12 6 49594 250 42571485
Accidental overdose 12.29 11.12 9 49591 28321 42543414
Red blood cell sedimentation rate increased 12.17 11.12 32 49568 9892 42561843
Sinus polyp 12.12 11.12 6 49594 259 42571476
Bladder diverticulum 12.11 11.12 5 49595 140 42571595
Iron deficiency anaemia 12.06 11.12 38 49562 13001 42558734
Cardio-respiratory arrest 12.02 11.12 32 49568 58604 42513131
Chest X-ray abnormal 12.01 11.12 20 49580 4488 42567247
Neuroleptic malignant syndrome 11.95 11.12 5 49595 21467 42550268
Upper gastrointestinal haemorrhage 11.93 11.12 68 49532 30231 42541504
JC virus CSF test positive 11.92 11.12 5 49595 146 42571589
Haematochezia 11.90 11.12 32 49568 58404 42513331
Chronic obstructive pulmonary disease 11.89 11.12 119 49481 62995 42508740
Bronchoalveolar lavage 11.89 11.12 4 49596 62 42571673
Intervertebral disc protrusion 11.88 11.12 34 49566 11038 42560697
Back pain 11.77 11.12 231 49369 141545 42430190
Obesity 11.75 11.12 44 49556 16415 42555320
Joint swelling 11.75 11.12 126 49474 67896 42503839
Pulmonary function test abnormal 11.62 11.12 15 49585 2679 42569056
Neoplasm progression 11.59 11.12 10 49590 28990 42542745
Lenticular opacities 11.55 11.12 6 49594 287 42571448
Rhinitis allergic 11.54 11.12 18 49582 3824 42567911
Blood pressure systolic abnormal 11.49 11.12 22 49578 5506 42566229
Eosinophilic pneumonia chronic 11.28 11.12 6 49594 301 42571434
Actinic keratosis 11.25 11.12 21 49579 5155 42566580
Malignant neoplasm of thymus 11.19 11.12 3 49597 20 42571715
Appendicitis 11.15 11.12 5 49595 20608 42551127
Tooth impacted 11.14 11.12 4 49596 76 42571659

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Femur fracture 3222.53 11.12 2252 541459 42217 110003371
Osteonecrosis of jaw 2583.34 11.12 2033 541678 45984 109999604
Pemphigus 2307.76 11.12 3935 539776 210635 109834953
Glossodynia 2171.58 11.12 3905 539806 218099 109827489
Osteonecrosis 2164.66 11.12 1587 542124 32154 110013434
Systemic lupus erythematosus 2141.04 11.12 4195 539516 250143 109795445
Hand deformity 2111.11 11.12 3823 539888 214683 109830905
Arthropathy 1759.45 11.12 4168 539543 283354 109762234
Pericarditis 1756.78 11.12 3542 540169 215572 109830016
Impaired healing 1753.21 11.12 3325 540386 193392 109852196
Anti-cyclic citrullinated peptide antibody positive 1714.14 11.12 3150 540561 178834 109866754
Wound 1708.78 11.12 3644 540067 230793 109814795
Toxicity to various agents 1624.62 11.12 220 543491 480335 109565253
Synovitis 1614.05 11.12 3915 539796 270177 109775411
Atypical femur fracture 1614.03 11.12 729 542982 5490 110040098
Duodenal ulcer perforation 1599.95 11.12 3017 540694 174683 109870905
Helicobacter infection 1512.65 11.12 2986 540725 178891 109866697
Acute kidney injury 1339.53 11.12 729 542982 634701 109410887
Folliculitis 1235.95 11.12 2619 541092 165034 109880554
Alopecia 1235.17 11.12 4272 539439 360481 109685107
Low turnover osteopathy 1230.18 11.12 438 543273 1584 110044004
Irritable bowel syndrome 1214.84 11.12 2569 541142 161646 109883942
Abdominal discomfort 1210.07 11.12 4468 539243 389390 109656198
Swelling 1160.39 11.12 4079 539632 346962 109698626
Death 1138.15 11.12 1057 542654 697812 109347776
Febrile neutropenia 1124.03 11.12 123 543588 316644 109728944
Muscle injury 1106.06 11.12 2258 541453 138549 109907039
Neutropenia 1067.28 11.12 264 543447 374356 109671232
Osteoarthritis 1037.39 11.12 2574 541137 180049 109865539
Discomfort 998.65 11.12 2809 540902 211898 109833690
Stress fracture 992.93 11.12 550 543161 6671 110038917
Completed suicide 990.70 11.12 48 543663 242333 109803255
Hepatic enzyme increased 990.66 11.12 3647 540064 317245 109728343
Rheumatoid factor positive 971.79 11.12 2058 541653 129582 109916006
Infusion related reaction 954.15 11.12 4056 539655 377106 109668482
Rheumatic fever 937.04 11.12 1944 541767 120635 109924953
Drug interaction 926.13 11.12 666 543045 499517 109546071
Blister 913.61 11.12 2824 540887 224552 109821036
Contraindicated product administered 909.62 11.12 2987 540724 245280 109800308
Type 2 diabetes mellitus 876.84 11.12 2372 541339 174860 109870728
Hypotension 876.38 11.12 772 542939 523077 109522511
Dental caries 865.05 11.12 621 543090 12152 110033436
Osteomyelitis 859.85 11.12 979 542732 35621 110009967
Fibromyalgia 846.11 11.12 2288 541423 168621 109876967
Blood cholesterol increased 842.97 11.12 2401 541310 182384 109863204
Therapeutic product effect decreased 820.47 11.12 2855 540856 241461 109804127
Off label use 792.98 11.12 4248 539463 1495937 108549651
Psoriatic arthropathy 786.79 11.12 2440 541271 194321 109851267
Sleep disorder due to general medical condition, insomnia type 765.06 11.12 1639 542072 104004 109941584
Drug abuse 762.67 11.12 24 543687 177387 109868201
Joint swelling 743.84 11.12 4205 539506 438640 109606948
Bursitis 740.48 11.12 1834 541877 128084 109917504
Disease progression 726.55 11.12 156 543555 243878 109801710
Facet joint syndrome 707.77 11.12 1508 542203 95320 109950268
Thrombocytopenia 693.27 11.12 429 543282 348456 109697132
Maternal exposure during pregnancy 692.00 11.12 2782 540929 252101 109793487
Ill-defined disorder 691.02 11.12 2013 541698 154840 109890748
Drug intolerance 685.17 11.12 3864 539847 402648 109642940
Jaw disorder 681.26 11.12 384 543327 4828 110040760
Hypersensitivity 674.89 11.12 3831 539880 400167 109645421
COVID-19 644.81 11.12 201 543510 244859 109800729
Swollen joint count increased 641.76 11.12 1329 542382 82332 109963256
Tooth disorder 629.15 11.12 751 542960 28758 110016830
Joint range of motion decreased 628.04 11.12 1656 542055 120176 109925412
Anaemia 619.36 11.12 1088 542623 545998 109499590
Lip dry 618.64 11.12 1458 542253 98625 109946963
Product dose omission issue 616.98 11.12 412 543299 321370 109724218
Injury 581.43 11.12 2056 541655 175209 109870379
Stomatitis 574.42 11.12 2741 540970 267501 109778087
Oral infection 570.61 11.12 368 543343 5993 110039595
Lower respiratory tract infection 565.58 11.12 2532 541179 240574 109805014
Hypercholesterolaemia 562.17 11.12 1324 542387 89513 109956075
Intentional overdose 555.27 11.12 22 543689 132479 109913109
Fracture nonunion 539.82 11.12 223 543488 1311 110044277
Liver injury 531.10 11.12 1788 541923 148625 109896963
Sepsis 522.52 11.12 503 543208 326843 109718745
Cardiac arrest 520.04 11.12 160 543551 196593 109848995
Inflammation 511.39 11.12 2093 541618 191145 109854443
Peripheral venous disease 509.63 11.12 1216 542495 82901 109962687
Nausea 507.98 11.12 3777 539934 1231913 108813675
Adverse event 498.01 11.12 1416 542295 107393 109938195
Exostosis of jaw 491.10 11.12 196 543515 1039 110044549
Malignant neoplasm progression 491.00 11.12 126 543585 174441 109871147
Gastrointestinal disorder 478.97 11.12 2405 541306 239547 109806041
Breast cancer stage III 461.37 11.12 1127 542584 77990 109967598
Platelet count decreased 438.97 11.12 297 543414 230146 109815442
Temporomandibular joint syndrome 431.17 11.12 257 543454 3612 110041976
Exostosis 427.63 11.12 792 542919 45164 110000424
C-reactive protein abnormal 426.64 11.12 1506 542205 128189 109917399
Lower limb fracture 423.17 11.12 1058 542653 74290 109971298
Grip strength decreased 411.27 11.12 1088 542623 79086 109966502
Obesity 411.22 11.12 1360 542351 111991 109933597
Mobility decreased 408.18 11.12 2270 541441 235152 109810436
Wound infection 399.93 11.12 1212 542499 95253 109950335
Multiple organ dysfunction syndrome 399.75 11.12 124 543587 151586 109894002
Road traffic accident 387.29 11.12 1286 542425 106112 109939476
White blood cell count decreased 386.72 11.12 335 543376 229055 109816533
Suicide attempt 385.30 11.12 33 543678 103361 109942227
Pancytopenia 384.92 11.12 281 543430 209332 109836256
Hyperhidrosis 383.48 11.12 222 543489 187076 109858512
Seizure 379.00 11.12 318 543393 220867 109824721
Gastrooesophageal reflux disease 374.59 11.12 1815 541896 178161 109867427
Musculoskeletal stiffness 372.55 11.12 2504 541207 277318 109768270
Tooth fracture 371.62 11.12 388 543323 12779 110032809
Bone disorder 371.39 11.12 489 543222 20703 110024885
Sciatica 370.99 11.12 1148 542563 91251 109954337
Respiratory failure 368.45 11.12 310 543401 215022 109830566
Deep vein thrombosis postoperative 363.30 11.12 861 542850 58430 109987158
Renal failure 361.60 11.12 348 543363 226226 109819362
Contusion 360.59 11.12 2169 541542 231192 109814396
Somnolence 357.98 11.12 568 543143 296881 109748707
Myelosuppression 357.39 11.12 28 543683 94312 109951276
Diarrhoea 351.80 11.12 3746 539965 1135759 108909829
Dry mouth 349.15 11.12 1920 541791 198028 109847560
Gait inability 339.45 11.12 1450 542261 134926 109910662
Gingival disorder 337.79 11.12 226 543485 3927 110041661
Atypical fracture 336.89 11.12 143 543568 909 110044679
Musculoskeletal pain 334.11 11.12 1779 541932 181244 109864344
Night sweats 331.51 11.12 1422 542289 132561 109913027
Periodontal disease 325.46 11.12 171 543540 1851 110043737
Live birth 318.60 11.12 905 542806 68579 109977009
Pulmonary fibrosis 314.40 11.12 1160 542551 100882 109944706
Cardio-respiratory arrest 313.67 11.12 90 543621 115746 109929842
Anaemia postoperative 310.74 11.12 163 543548 1758 110043830
Neutrophil count decreased 309.50 11.12 104 543607 120837 109924751
Drug ineffective 303.91 11.12 5460 538251 1515080 108530508
Dehydration 303.21 11.12 570 543141 278941 109766647
Lactic acidosis 302.63 11.12 47 543664 92764 109952824
Pathological fracture 301.64 11.12 333 543378 11699 110033889
Constipation 298.96 11.12 840 542871 356946 109688642
Lung disorder 297.80 11.12 1704 542007 178343 109867245
Blood parathyroid hormone decreased 297.06 11.12 344 543367 12745 110032843
Autoimmune disorder 294.52 11.12 847 542864 64636 109980952
Tooth loss 294.45 11.12 274 543437 7822 110037766
Drug ineffective for unapproved indication 293.44 11.12 72 543639 102766 109942822
Arthralgia 292.71 11.12 5419 538292 774213 109271375
Hip arthroplasty 286.81 11.12 758 542953 55055 109990533
Nail disorder 283.79 11.12 773 542938 57162 109988426
Treatment failure 283.15 11.12 2330 541381 274904 109770684
Injection site pain 283.02 11.12 274 543437 177648 109867940
Blood creatinine increased 282.49 11.12 289 543422 182600 109862988
Bone density decreased 280.86 11.12 370 543341 15672 110029916
Wheezing 280.79 11.12 2182 541529 253048 109792540
Sinusitis 279.54 11.12 2449 541262 294239 109751349
Electrocardiogram QT prolonged 276.56 11.12 95 543616 108865 109936723
Peripheral swelling 273.56 11.12 3114 540597 400920 109644668
Sleep disorder 273.56 11.12 1793 541918 196851 109848737
Intentional product misuse 272.77 11.12 157 543554 132747 109912841
Leukopenia 272.43 11.12 200 543511 148591 109896997
Cytokine release syndrome 271.64 11.12 19 543692 70287 109975301
Cough 270.25 11.12 1258 542453 460383 109585205
Granuloma skin 268.68 11.12 304 543407 10979 110034609
Depressed level of consciousness 268.00 11.12 108 543603 112170 109933418
Onychomadesis 267.81 11.12 652 543059 45011 110000577
Hypoaesthesia 267.73 11.12 2538 541173 311685 109733903
Jaw fracture 266.97 11.12 176 543535 2980 110042608
Tremor 264.87 11.12 364 543347 201868 109843720
Dislocation of vertebra 264.71 11.12 632 543079 43089 110002499
Bradycardia 264.64 11.12 225 543486 155292 109890296
Adjustment disorder with depressed mood 262.09 11.12 631 543080 43252 110002336
Blepharospasm 260.87 11.12 724 542987 54127 109991461
Mucosal inflammation 259.75 11.12 75 543636 96066 109949522
Rheumatoid nodule 259.43 11.12 403 543308 19893 110025695
Resorption bone increased 259.12 11.12 134 543577 1400 110044188
Fracture delayed union 257.84 11.12 151 543560 2050 110043538
Septic shock 254.75 11.12 239 543472 157289 109888299
Bone loss 252.69 11.12 168 543543 2887 110042701
Rhabdomyolysis 251.74 11.12 139 543572 120262 109925326
Drug reaction with eosinophilia and systemic symptoms 251.41 11.12 49 543662 82046 109963542
Hyperkalaemia 250.61 11.12 181 543530 135615 109909973
Pulmonary embolism 248.21 11.12 420 543291 214054 109831534
Haemoglobin decreased 247.68 11.12 533 543178 248194 109797394
Metabolic acidosis 246.26 11.12 91 543620 99653 109945935
Adverse drug reaction 244.86 11.12 1099 542612 104460 109941128
Pyrexia 242.41 11.12 3041 540670 895224 109150364
Infection 240.38 11.12 2781 540930 359419 109686169
Sedation 239.63 11.12 30 543681 69653 109975935
Panniculitis 234.46 11.12 334 543377 15248 110030340
Inappropriate schedule of product administration 231.78 11.12 403 543308 203234 109842354
Encephalopathy 230.77 11.12 57 543654 80998 109964590
Product use issue 230.00 11.12 2444 541267 309251 109736337
Foot deformity 229.65 11.12 639 543072 47841 109997747
Loose tooth 229.11 11.12 162 543549 3091 110042497
Renal impairment 228.38 11.12 358 543353 188087 109857501
Knee arthroplasty 228.15 11.12 771 542940 64177 109981411
Onychomycosis 227.92 11.12 552 543159 37979 110007609
Hypertension 227.79 11.12 3647 540064 506437 109539151
Agitation 224.33 11.12 139 543572 112912 109932676
Intervertebral disc degeneration 224.07 11.12 354 543357 17731 110027857
Vomiting 223.83 11.12 3143 540568 907532 109138056
Overdose 223.76 11.12 512 543199 233282 109812306
Ascites 220.31 11.12 90 543621 92718 109952870
Osteoporosis 215.54 11.12 925 542786 86227 109959361
Edentulous 213.49 11.12 69 543642 169 110045419
Pneumonia 212.51 11.12 3034 540677 873680 109171908
Drug resistance 210.01 11.12 18 543693 56356 109989232
Back injury 209.19 11.12 609 543102 46790 109998798
Retinitis 208.46 11.12 479 543232 31848 110013740
Blood glucose increased 208.44 11.12 206 543505 132290 109913298
Feeling abnormal 207.14 11.12 356 543355 180355 109865233
Oral cavity fistula 205.55 11.12 89 543622 598 110044990
Nasopharyngitis 204.86 11.12 2894 540817 391467 109654121
Hepatic cytolysis 203.94 11.12 18 543693 55035 109990553
Neuropathy peripheral 203.83 11.12 355 543356 178922 109866666
Tachycardia 203.70 11.12 513 543198 226132 109819456
Flushing 202.03 11.12 133 543578 104603 109940985
Spinal osteoarthritis 201.93 11.12 359 543352 19824 110025764
Cognitive disorder 201.12 11.12 89 543622 87422 109958166
Hyperlipidaemia 200.85 11.12 503 543208 35345 110010243
Neoplasm progression 194.78 11.12 40 543671 64555 109981033
Cardiac failure 194.40 11.12 393 543318 187233 109858355
Angioedema 194.20 11.12 122 543589 98378 109947210
Loss of consciousness 192.65 11.12 424 543287 195882 109849706
Foot fracture 192.51 11.12 403 543308 25143 110020445
Pulmonary oedema 188.57 11.12 132 543579 100527 109945061
Drug tolerance decreased 187.54 11.12 417 543294 27123 110018465
Rash erythematous 186.84 11.12 84 543627 81748 109963840
Lupus vulgaris 186.25 11.12 472 543239 33411 110012177
Spondylolisthesis 185.41 11.12 152 543559 3646 110041942
Chest discomfort 185.40 11.12 358 543353 173490 109872098
Colitis 184.12 11.12 140 543571 102183 109943405
Prescribed overdose 184.08 11.12 886 542825 86695 109958893
Periodontitis 183.14 11.12 173 543538 5035 110040553
Tooth abscess 182.59 11.12 330 543381 18459 110027129
Respiratory arrest 182.35 11.12 33 543678 58266 109987322
Ulna fracture 181.72 11.12 99 543612 1159 110044429
Hyponatraemia 181.68 11.12 511 543200 217142 109828446
Wrong technique in product usage process 180.92 11.12 102 543609 87246 109958342
C-reactive protein 178.83 11.12 434 543277 29897 110015691
Oral disorder 178.71 11.12 256 543455 11747 110033841
Red blood cell sedimentation rate increased 177.67 11.12 810 542901 77492 109968096
Pleural effusion 177.55 11.12 380 543331 177329 109868259
X-ray abnormal 177.19 11.12 499 543212 37618 110007970
Haematochezia 176.72 11.12 184 543527 115340 109930248
Weight increased 176.69 11.12 2972 540739 416672 109628916
Suicidal ideation 176.21 11.12 123 543588 93814 109951774
Hepatic failure 176.05 11.12 59 543652 68680 109976908
Anaphylactic reaction 176.03 11.12 181 543530 114119 109931469
Hypoglycaemia 175.27 11.12 187 543524 115917 109929671
Dry skin 174.42 11.12 163 543548 107490 109938098
Myocardial infarction 173.97 11.12 433 543278 191650 109853938
Cardiogenic shock 173.94 11.12 35 543676 57303 109988285
Dyspnoea 170.64 11.12 4143 539568 1102729 108942859
Exposed bone in jaw 168.41 11.12 144 543567 3667 110041921
Anaphylactic shock 168.27 11.12 26 543685 51520 109994068
Abscess jaw 167.79 11.12 107 543604 1707 110043881
Diverticulum 166.83 11.12 285 543426 15241 110030347
Epistaxis 166.34 11.12 239 543472 130133 109915455
Erythema 165.83 11.12 802 542909 290645 109754943
Gingivitis 165.19 11.12 228 543483 10103 110035485
Illness 164.46 11.12 100 543611 82071 109963517
Uterine disorder 164.20 11.12 116 543595 2210 110043378
Cytomegalovirus infection 163.57 11.12 34 543677 54410 109991178
Liver disorder 163.54 11.12 1229 542482 141014 109904574
Product label confusion 161.94 11.12 350 543361 22327 110023261
General physical health deterioration 161.85 11.12 2964 540747 422331 109623257
Aggression 160.29 11.12 46 543665 59164 109986424
Cholestasis 159.03 11.12 59 543652 64459 109981129
Serotonin syndrome 156.41 11.12 48 543663 59105 109986483
Device failure 156.21 11.12 185 543526 7022 110038566
Toxic epidermal necrolysis 155.55 11.12 43 543668 56684 109988904
Intentional product use issue 155.30 11.12 1883 541828 246023 109799565
Prescribed underdose 152.96 11.12 681 543030 64493 109981095
Fibrocystic breast disease 152.83 11.12 73 543638 633 110044955
Blood bilirubin increased 152.68 11.12 92 543619 75880 109969708
Neurotoxicity 150.54 11.12 16 543695 42191 110003397
Atrial fibrillation 149.35 11.12 601 543110 229041 109816547
Fracture displacement 149.16 11.12 92 543619 1380 110044208
Rash maculo-papular 149.00 11.12 90 543621 74132 109971456
Laryngitis 147.65 11.12 502 543209 41909 110003679
Osteopenia 147.55 11.12 333 543378 21876 110023712
Bone marrow failure 147.54 11.12 50 543661 57798 109987790
Skin necrosis 146.78 11.12 326 543385 21186 110024402
Disturbance in attention 145.72 11.12 61 543650 61934 109983654
Tonsillar disorder 145.66 11.12 91 543620 1398 110044190
Pneumonitis 145.15 11.12 99 543612 76432 109969156
Sopor 143.76 11.12 9 543702 36537 110009051
Injection site erythema 142.91 11.12 151 543560 94025 109951563
Intramedullary rod insertion 142.27 11.12 51 543660 189 110045399
Hepatocellular injury 141.48 11.12 37 543674 50605 109994983
Pain 141.47 11.12 5888 537823 949067 109096521
Hip fracture 140.36 11.12 436 543275 34715 110010873
C-reactive protein increased 140.32 11.12 1664 542047 216255 109829333
Alveolar osteitis 139.27 11.12 79 543632 1006 110044582
Taste disorder 139.22 11.12 664 543047 64723 109980865
Accidental exposure to product 138.83 11.12 37 543674 49971 109995617
Clostridium difficile infection 138.37 11.12 42 543669 52087 109993501
Bone erosion 136.83 11.12 520 543191 45851 109999737
Blood pressure increased 136.73 11.12 729 542982 257644 109787944
Intentional self-injury 136.60 11.12 13 543698 37416 110008172
Pericardial effusion 136.59 11.12 55 543656 57162 109988426
Dental fistula 136.50 11.12 64 543647 530 110045058
Tibia fracture 136.10 11.12 165 543546 6420 110039168
Joint dislocation 135.52 11.12 423 543288 33767 110011821
Lupus-like syndrome 135.18 11.12 475 543236 40317 110005271
Cerumen impaction 134.97 11.12 86 543625 1370 110044218
Therapy partial responder 134.91 11.12 13 543698 37048 110008540
Generalised tonic-clonic seizure 133.10 11.12 51 543660 54629 109990959
Cerebrovascular accident 132.56 11.12 452 543259 180832 109864756
Agranulocytosis 132.45 11.12 69 543642 61691 109983897
Weight decreased 131.78 11.12 1569 542142 466488 109579100
Osteitis 131.03 11.12 132 543579 4164 110041424
Oxygen saturation decreased 130.65 11.12 369 543342 156613 109888975
Basal cell carcinoma 130.58 11.12 504 543207 44766 110000822
Acute respiratory distress syndrome 130.52 11.12 49 543662 53149 109992439
Depression 130.40 11.12 2239 541472 315096 109730492
Abortion spontaneous 130.32 11.12 10 543701 34272 110011316
Fistula discharge 130.10 11.12 88 543623 1558 110044030
Eosinophilia 129.88 11.12 61 543650 57875 109987713
Finger deformity 129.86 11.12 408 543303 32684 110012904
Restlessness 129.61 11.12 57 543654 56202 109989386
Spinal compression fracture 129.20 11.12 282 543429 18110 110027478
Anti-cyclic citrullinated peptide antibody 128.92 11.12 296 543415 19668 110025920
Drug hypersensitivity 128.87 11.12 3031 540680 451059 109594529
Periprosthetic fracture 128.74 11.12 67 543644 710 110044878
Dental necrosis 128.03 11.12 43 543668 124 110045464
Urinary tract infection 126.28 11.12 1012 542699 325270 109720318
Dyspepsia 125.50 11.12 1464 542247 189501 109856087
Premature delivery 125.28 11.12 6 543705 30626 110014962
Acute myocardial infarction 125.26 11.12 136 543575 83641 109961947
Aphasia 124.92 11.12 67 543644 58930 109986658
Chills 123.76 11.12 499 543212 190081 109855507
Therapy interrupted 123.74 11.12 45 543666 49777 109995811
Coeliac disease 123.09 11.12 479 543232 42708 110002880
Disorientation 122.96 11.12 100 543611 70571 109975017
Hypokalaemia 122.75 11.12 471 543240 181977 109863611
Incorrect dose administered 122.60 11.12 200 543511 103441 109942147
Ventricular fibrillation 121.66 11.12 27 543684 41286 110004302
Diabetic ketoacidosis 120.84 11.12 29 543682 42029 110003559
Shock 120.79 11.12 56 543655 53532 109992056
Posterior reversible encephalopathy syndrome 120.35 11.12 13 543698 33848 110011740
Coma 120.27 11.12 249 543462 117620 109927968
Transaminases increased 120.22 11.12 82 543629 63308 109982280
Confusional state 120.00 11.12 3085 540626 465595 109579993
Psychotic disorder 119.91 11.12 50 543661 50887 109994701
Hypoxia 119.57 11.12 289 543422 129226 109916362
Scoliosis 119.51 11.12 179 543532 8554 110037034
Oedema 119.15 11.12 1566 542145 208410 109837178
Dysarthria 118.78 11.12 143 543568 83978 109961610
Palmar-plantar erythrodysaesthesia syndrome 118.44 11.12 28 543683 40997 110004591
Blood pressure decreased 118.39 11.12 242 543469 114849 109930739
Pallor 118.29 11.12 65 543646 56402 109989186
Syncope 117.70 11.12 553 543158 201983 109843605
Hallucination 116.96 11.12 199 543512 101233 109944355
Maternal exposure timing unspecified 116.82 11.12 294 543417 20719 110024869
COVID-19 pneumonia 116.22 11.12 21 543690 37122 110008466
Migraine 115.50 11.12 1322 542389 170330 109875258
Status epilepticus 115.12 11.12 11 543700 31560 110014028
Stress 114.88 11.12 214 543497 105134 109940454
Pelvic fracture 114.57 11.12 230 543481 13924 110031664
Skin exfoliation 114.47 11.12 158 543553 87493 109958095
Injection site swelling 114.45 11.12 82 543629 61708 109983880
Respiratory distress 114.28 11.12 102 543609 68772 109976816
Tumour lysis syndrome 114.28 11.12 10 543701 30791 110014797
Breast disorder 113.78 11.12 93 543618 2221 110043367
Skin discolouration 112.50 11.12 50 543661 48996 109996592
Influenza 111.55 11.12 440 543271 168661 109876927
Radius fracture 111.32 11.12 117 543594 3883 110041705
Pregnancy 111.21 11.12 522 543189 50545 109995043
Haemorrhage 110.03 11.12 224 543487 106468 109939120
Plasma cell myeloma 109.57 11.12 89 543622 62847 109982741
Neuroleptic malignant syndrome 109.33 11.12 18 543693 34041 110011547
Eczema 108.48 11.12 117 543594 72176 109973412
Lethargy 108.43 11.12 183 543528 93393 109952195
Unevaluable event 107.87 11.12 80 543631 59147 109986441
Haemophagocytic lymphohistiocytosis 107.50 11.12 14 543697 31545 110014043
Nightmare 107.42 11.12 29 543682 38834 110006754
Drug level increased 107.35 11.12 50 543661 47669 109997919
Unresponsive to stimuli 106.41 11.12 94 543617 63696 109981892
Stress urinary incontinence 106.38 11.12 83 543628 1850 110043738
Abnormal behaviour 106.28 11.12 30 543681 39009 110006579
Acute myeloid leukaemia 106.17 11.12 28 543683 38082 110007506
Ulcer 106.10 11.12 457 543254 42659 110002929
Palpitations 105.19 11.12 414 543297 158798 109886790
Drug tolerance 103.91 11.12 243 543468 16342 110029246
Poisoning 103.89 11.12 11 543700 29094 110016494
Dysgeusia 103.10 11.12 115 543596 69870 109975718
Depressed mood 102.17 11.12 89 543622 60720 109984868
Abscess oral 101.61 11.12 75 543636 1534 110044054
Rotator cuff syndrome 100.82 11.12 242 543469 16552 110029036
Brain oedema 100.80 11.12 16 543695 31082 110014506
Hypervolaemia 100.64 11.12 59 543652 49401 109996187
Mental status changes 100.64 11.12 136 543575 75986 109969602
Osteonecrosis of external auditory canal 99.31 11.12 40 543671 218 110045370
Product prescribing error 99.23 11.12 65 543646 51266 109994322
Hepatotoxicity 99.20 11.12 99 543612 63301 109982287
Nasal congestion 98.27 11.12 210 543501 98072 109947516
Blood creatine phosphokinase increased 98.20 11.12 129 543582 72948 109972640
Irritability 97.33 11.12 57 543654 47752 109997836
Hemiparesis 97.23 11.12 47 543664 43856 110001732
Lymphocyte count decreased 97.12 11.12 83 543628 57160 109988428
Hypomagnesaemia 97.09 11.12 92 543619 60278 109985310
Fibula fracture 96.32 11.12 116 543595 4482 110041106
Hyperglycaemia 96.22 11.12 169 543542 84921 109960667
Acute respiratory failure 95.96 11.12 138 543573 75122 109970466
Rib fracture 95.79 11.12 374 543337 33396 110012192
Ventricular tachycardia 95.76 11.12 64 543647 49945 109995643
Kyphosis 95.51 11.12 97 543614 3090 110042498
Bacteraemia 94.46 11.12 45 543666 42345 110003243
Dystonia 94.07 11.12 9 543702 25796 110019792
Respiratory depression 94.06 11.12 21 543690 31980 110013608
Appendix disorder 93.80 11.12 76 543635 1792 110043796
Pulmonary vasculitis 93.42 11.12 137 543574 6423 110039165
Neuritis 93.28 11.12 146 543565 7253 110038335
Rhinorrhoea 93.26 11.12 231 543480 102435 109943153
Hyperaesthesia teeth 93.08 11.12 83 543628 2239 110043349
Tendonitis 92.79 11.12 311 543400 25772 110019816
Lumbar spinal stenosis 92.56 11.12 135 543576 6298 110039290
Adverse reaction 92.43 11.12 338 543373 29256 110016332
Acute hepatic failure 92.17 11.12 32 543679 36436 110009152
Therapy cessation 92.00 11.12 53 543658 44804 110000784
Myocarditis 91.89 11.12 18 543693 30037 110015551
Product quality issue 91.72 11.12 673 543038 76626 109968962
Withdrawal syndrome 91.42 11.12 21 543690 31359 110014229
Pancreatitis acute 91.05 11.12 97 543614 60177 109985411
Red blood cell sedimentation rate 90.87 11.12 120 543591 5094 110040494
Muscle strain 90.64 11.12 182 543529 11020 110034568
Altered state of consciousness 90.14 11.12 90 543621 57536 109988052
Mycotic allergy 90.13 11.12 128 543583 5826 110039762
Thrombotic microangiopathy 90.09 11.12 17 543694 29132 110016456
Wrist fracture 90.07 11.12 211 543500 14206 110031382
Red blood cell count decreased 89.99 11.12 115 543596 65808 109979780
Device issue 89.56 11.12 29 543682 34506 110011082
Orthostatic hypotension 88.96 11.12 117 543594 66132 109979456
Vitamin D deficiency 88.31 11.12 245 543466 18307 110027281
Vision blurred 88.12 11.12 331 543380 128691 109916897
Dyskinesia 88.01 11.12 74 543637 51372 109994216
Cerebral haemorrhage 88 11.12 114 543597 64854 109980734
Multiple sclerosis relapse 87.52 11.12 71 543640 50169 109995419
Porphyria acute 87.42 11.12 246 543465 18534 110027054
Urticaria 87.22 11.12 2118 541593 316739 109728849
Stevens-Johnson syndrome 87.18 11.12 62 543649 46839 109998749
Tubulointerstitial nephritis 86.98 11.12 83 543628 54201 109991387
Synovial cyst 86.92 11.12 181 543530 11249 110034339
Haematocrit decreased 86.52 11.12 119 543592 65998 109979590
Disease recurrence 86.16 11.12 103 543608 60681 109984907
Therapeutic response shortened 85.78 11.12 20 543691 29563 110016025
Lumbar radiculopathy 85.66 11.12 83 543628 2495 110043093
Impaired quality of life 85.65 11.12 21 543690 29996 110015592
Neutropenic sepsis 84.87 11.12 23 543688 30723 110014865
Ear pain 84.18 11.12 498 543213 52728 109992860
Eye pruritus 84.15 11.12 28 543683 32747 110012841
Patellofemoral pain syndrome 84.01 11.12 45 543666 508 110045080
Asthenia 83.67 11.12 2665 541046 686334 109359254
Jaw operation 83.62 11.12 52 543659 792 110044796
Haematotoxicity 83.50 11.12 5 543706 21077 110024511
Atrophic vulvovaginitis 83.37 11.12 63 543648 1337 110044251
Osteoradionecrosis 82.90 11.12 30 543681 115 110045473
Arthritis 82.56 11.12 1219 542492 166367 109879221
Breast cancer stage II 82.43 11.12 309 543402 27066 110018522
End stage renal disease 82.38 11.12 6 543705 21467 110024121
Abdominal pain 82.33 11.12 1907 541804 511082 109534506
Cytopenia 82.25 11.12 23 543688 30093 110015495
Eosinophilic granulomatosis with polyangiitis 82.18 11.12 170 543541 10516 110035072
Hiatus hernia 81.80 11.12 310 543401 27296 110018292
Hemiplegia 80.33 11.12 9 543702 22773 110022815
Seronegative arthritis 80.31 11.12 191 543520 12986 110032602
Renal tubular necrosis 80.08 11.12 25 543686 30450 110015138
Mydriasis 80.05 11.12 8 543703 22149 110023439
Pain in jaw 79.76 11.12 477 543234 50700 109994888
Gamma-glutamyltransferase increased 79.57 11.12 111 543600 61198 109984390
Hyperbilirubinaemia 79.11 11.12 26 543685 30645 110014943
Troponin increased 78.97 11.12 24 543687 29742 110015846
Ischaemic stroke 78.75 11.12 53 543658 41210 110004378
Meniscus injury 78.45 11.12 139 543572 7654 110037934
Hypercalcaemia 77.99 11.12 443 543268 46214 109999374
Gastrointestinal haemorrhage 77.87 11.12 485 543226 165033 109880555
Memory impairment 77.75 11.12 1381 542330 195563 109850025
International normalised ratio increased 77.45 11.12 197 543514 86575 109959013
Rash 77.44 11.12 4849 538862 816115 109229473
Tachypnoea 77.36 11.12 49 543662 39346 110006242
Extrapyramidal disorder 77.08 11.12 23 543688 28844 110016744
Oropharyngeal pain 77.02 11.12 372 543339 134904 109910684
Drug withdrawal syndrome 76.57 11.12 46 543665 38008 110007580
Epilepsy 76.25 11.12 791 542920 99418 109946170
Hepatic function abnormal 75.69 11.12 208 543503 89087 109956501
Dyspnoea exertional 75.68 11.12 260 543451 103800 109941788
Aplastic anaemia 75.50 11.12 14 543697 24294 110021294
Device dislocation 74.82 11.12 31 543680 31673 110013915
Ejection fraction decreased 74.73 11.12 55 543656 40825 110004763
Skin ulcer 74.30 11.12 552 543159 63093 109982495
Osteomyelitis chronic 73.69 11.12 47 543664 750 110044838
Insomnia 73.69 11.12 2307 541404 358283 109687305
Myoclonus 73.57 11.12 35 543676 32963 110012625
Creatinine renal clearance decreased 73.54 11.12 10 543701 21805 110023783
Large intestine polyp 73.31 11.12 201 543510 14916 110030672
Cystocele 73.19 11.12 52 543659 1000 110044588
Spinal fracture 72.80 11.12 261 543450 22372 110023216
Pneumocystis jirovecii pneumonia 72.46 11.12 62 543649 42673 110002915
Transplant rejection 72.45 11.12 16 543695 24551 110021037
Shock haemorrhagic 72.23 11.12 22 543689 27225 110018363
Rash macular 72.09 11.12 51 543660 38635 110006953
Urinary tract discomfort 71.80 11.12 50 543661 930 110044658
Toxic skin eruption 71.54 11.12 23 543688 27492 110018096
Polymyalgia rheumatica 71.53 11.12 120 543591 6322 110039266
Anuria 71.49 11.12 16 543695 24325 110021263
Pulpitis dental 71.47 11.12 60 543651 1489 110044099
Aspergillus infection 71.02 11.12 19 543692 25597 110019991
Blood urea increased 70.83 11.12 100 543611 54857 109990731
Influenza like illness 70.50 11.12 212 543499 88200 109957388
Injection site bruising 70.42 11.12 89 543622 51174 109994414
Oroantral fistula 70.21 11.12 36 543675 369 110045219
Bone sequestrum 70.16 11.12 54 543657 1179 110044409
Muscle spasms 69.94 11.12 1827 541884 276330 109769258
Cardiac failure congestive 69.72 11.12 445 543266 150555 109895033
Skin haemorrhage 69.62 11.12 18 543693 24809 110020779
Arrhythmia 69.27 11.12 149 543562 69426 109976162
Proteinuria 69.15 11.12 57 543654 39961 110005627
Exposure during pregnancy 68.95 11.12 1182 542529 166242 109879346
Interstitial lung disease 68.84 11.12 402 543309 138932 109906656
Tenosynovitis 68.77 11.12 206 543505 16077 110029511
Injection site pruritus 68.34 11.12 91 543620 51167 109994421
Walking aid user 68.14 11.12 274 543437 24801 110020787
Accidental overdose 68.12 11.12 93 543618 51741 109993847
Staphylococcal infection 67.82 11.12 152 543559 69792 109975796
Hypophagia 67.58 11.12 96 543615 52530 109993058
Oedema mouth 67.26 11.12 80 543631 3050 110042538
Metastases to central nervous system 67.01 11.12 15 543696 22802 110022786
Carotid bruit 67.00 11.12 43 543668 694 110044894
Neutrophil count increased 66.82 11.12 44 543667 34608 110010980
Fractured sacrum 66.62 11.12 65 543646 1971 110043617
Jaw cyst 66.61 11.12 27 543684 150 110045438
Reversible airways obstruction 65.84 11.12 71 543640 2428 110043160
Total lung capacity abnormal 65.68 11.12 96 543615 4487 110041101
Chronic kidney disease 65.19 11.12 177 543534 76114 109969474
Blood lactate dehydrogenase increased 65.13 11.12 73 543638 44261 110001327
Akathisia 65.03 11.12 5 543706 17108 110028480
Pathogen resistance 64.85 11.12 6 543705 17666 110027922
Bone lesion 64.49 11.12 121 543590 6966 110038622
Hyperthermia 64.49 11.12 13 543698 21259 110024329
Cardiotoxicity 63.95 11.12 5 543706 16876 110028712
Limb asymmetry 63.83 11.12 40 543671 618 110044970
Sjogren's syndrome 63.61 11.12 42 543669 713 110044875
Hypothermia 63.24 11.12 25 543686 26277 110019311
Fistula 63.16 11.12 192 543519 15107 110030481
Urinary retention 63.12 11.12 157 543554 69526 109976062
Muscular weakness 63.04 11.12 1634 542077 246834 109798754
Full blood count decreased 62.93 11.12 40 543671 32059 110013529
Tenosynovitis stenosans 62.91 11.12 83 543628 3520 110042068
Nasal septum deviation 62.44 11.12 65 543646 2133 110043455
Neck pain 62.35 11.12 900 542811 122230 109923358
Deep vein thrombosis 62.18 11.12 417 543294 139470 109906118
Venoocclusive liver disease 62.12 11.12 3 543708 15204 110030384
Bacterial infection 62.12 11.12 81 543630 45955 109999633
Hallucination, auditory 61.99 11.12 26 543685 26371 110019217
Hepatic cirrhosis 61.90 11.12 555 543156 67071 109978517
Oliguria 61.84 11.12 9 543702 18648 110026940
Disseminated intravascular coagulation 61.74 11.12 67 543644 41219 110004369
Mitral valve prolapse 61.67 11.12 67 543644 2311 110043277
Haemodynamic instability 61.55 11.12 18 543693 22870 110022718
Injection site mass 61.51 11.12 22 543689 24591 110020997
Nephropathy toxic 61.48 11.12 29 543682 27449 110018139
Hepatic encephalopathy 61.43 11.12 31 543680 28225 110017363
Nodule 61.40 11.12 320 543391 32311 110013277
Alanine aminotransferase increased 61.32 11.12 592 543119 183181 109862407
Candida infection 61.23 11.12 88 543623 47921 109997667
Glomerular filtration rate decreased 61.13 11.12 33 543678 28923 110016665
Dental plaque 60.96 11.12 21 543690 67 110045521
Femoral neck fracture 60.85 11.12 167 543544 12400 110033188
Paraesthesia oral 60.65 11.12 46 543665 33625 110011963
Fluid retention 60.52 11.12 248 543463 94059 109951529
Metastases to liver 60.41 11.12 51 543660 35335 110010253
Vital capacity decreased 60.14 11.12 62 543649 2011 110043577
Electrolyte imbalance 60.04 11.12 56 543655 36972 110008616
Liver function test increased 60.00 11.12 683 543028 87865 109957723
Actinomycosis 59.97 11.12 51 543660 1289 110044299
Hypoalbuminaemia 59.75 11.12 34 543677 28940 110016648
Headache 59.74 11.12 3641 540070 878736 109166852
Miosis 59.64 11.12 17 543694 21966 110023622
Infusion site reaction 59.54 11.12 207 543504 17475 110028113
Hypersomnia 59.21 11.12 32 543679 28029 110017559
Rectocele 59.18 11.12 41 543670 756 110044832
Skin burning sensation 58.99 11.12 17 543694 21808 110023780
Amnesia 58.86 11.12 784 542927 104624 109940964
Metastases to lung 58.70 11.12 20 543691 23043 110022545
Pain in extremity 58.69 11.12 2943 540768 484175 109561413
Polyneuropathy 58.61 11.12 43 543668 31969 110013619
Immune reconstitution inflammatory syndrome 58.26 11.12 6 543705 16220 110029368
Oesophageal ulcer 58.10 11.12 124 543587 7840 110037748
Graft versus host disease 58.05 11.12 11 543700 18795 110026793
Muscle twitching 57.73 11.12 38 543673 29897 110015691
Gingival recession 57.53 11.12 53 543658 1493 110044095
Muscle rigidity 57.52 11.12 23 543688 24008 110021580
Sequestrectomy 57.42 11.12 41 543670 795 110044793
Abdominal pain upper 57.35 11.12 2178 541533 346933 109698655
Klebsiella infection 57.08 11.12 14 543697 19995 110025593
Calcium deficiency 57.06 11.12 47 543664 1135 110044453
Tooth deposit 56.83 11.12 29 543682 294 110045294
Ligament sprain 56.63 11.12 191 543520 15877 110029711
Blood alkaline phosphatase increased 56.63 11.12 170 543541 70765 109974823
Animal scratch 56.48 11.12 57 543654 1802 110043786
Bone fragmentation 56.26 11.12 39 543672 720 110044868
Skin fissures 55.99 11.12 25 543686 24433 110021155
Joint effusion 55.66 11.12 227 543484 20678 110024910
Mood altered 55.34 11.12 18 543693 21357 110024231
Affect lability 55.24 11.12 12 543699 18625 110026963
Appendicitis 55.08 11.12 36 543675 28428 110017160
Throat tightness 55.07 11.12 50 543661 33439 110012149
Dermal sinus 54.98 11.12 15 543696 14 110045574
Throat irritation 54.73 11.12 113 543598 53439 109992149
Female genital tract fistula 54.68 11.12 8 543703 16511 110029077
Asthma 54.49 11.12 1614 542097 248677 109796911
Immune effector cell-associated neurotoxicity syndrome 54.30 11.12 5 543706 14777 110030811
Paranoia 54.23 11.12 21 543690 22353 110023235
Activated partial thromboplastin time prolonged 54.21 11.12 21 543690 22347 110023241
Proctitis 54.21 11.12 9 543702 16918 110028670
Infusion site pain 54.17 11.12 10 543701 17409 110028179
Labelled drug-drug interaction medication error 54.11 11.12 39 543672 29263 110016325
Device difficult to use 53.96 11.12 13 543698 18792 110026796
Blood phosphorus increased 53.89 11.12 8 543703 16332 110029256
Suspected suicide 53.60 11.12 6 543705 15193 110030395
Kyphoscoliosis 53.57 11.12 27 543684 266 110045322
Abscess 53.51 11.12 272 543439 27197 110018391
Heart rate decreased 53.50 11.12 217 543494 82539 109963049
Ulcer haemorrhage 53.06 11.12 236 543475 22335 110023253
Inflammatory marker increased 52.87 11.12 5 543706 14464 110031124
Multiple-drug resistance 52.84 11.12 3 543708 13232 110032356
Circulatory collapse 52.70 11.12 81 543630 42912 110002676
Tooth extraction 52.66 11.12 162 543549 12829 110032759
Cerebral infarction 52.45 11.12 110 543601 51728 109993860
Vascular device infection 52.39 11.12 9 543702 16503 110029085
Product dose omission in error 52.32 11.12 25 543686 23487 110022101
No adverse event 52.01 11.12 187 543524 73652 109971936
Thrombosis 51.83 11.12 317 543394 108345 109937243
Hypophosphataemia 51.70 11.12 52 543659 33130 110012458
Spirometry abnormal 51.45 11.12 95 543616 5402 110040186
Nervous system disorder 51.41 11.12 48 543663 31673 110013915
Clostridium difficile colitis 51.28 11.12 85 543626 43693 110001895
Dermatitis atopic 51.22 11.12 31 543680 25510 110020078
Coagulopathy 51.19 11.12 76 543635 40835 110004753
Heart rate increased 51.14 11.12 456 543255 143378 109902210
Exposure to toxic agent 51.08 11.12 3 543708 12855 110032733
Transfusion 50.96 11.12 31 543680 25441 110020147
Blood glucose decreased 50.95 11.12 42 543669 29446 110016142
Psychomotor hyperactivity 50.89 11.12 18 543693 20259 110025329
Blood uric acid increased 50.89 11.12 21 543690 21508 110024080
Second primary malignancy 50.85 11.12 13 543698 18055 110027533
Post transplant lymphoproliferative disorder 50.68 11.12 8 543703 15605 110029983
Product prescribing issue 50.67 11.12 3 543708 12769 110032819
Ataxia 50.66 11.12 44 543667 30064 110015524
Intestinal obstruction 50.53 11.12 117 543594 53110 109992478
Face oedema 50.39 11.12 54 543657 33415 110012173
Torsade de pointes 50.34 11.12 24 543687 22576 110023012
Lymphadenopathy 50.23 11.12 154 543557 63681 109981907
Bone metabolism disorder 50.14 11.12 33 543678 557 110045031
Cardiac failure acute 50.02 11.12 28 543683 24050 110021538
Device malfunction 49.89 11.12 32 543679 25526 110020062
Oral fibroma 49.89 11.12 14 543697 16 110045572
Renal injury 49.80 11.12 15 543696 18698 110026890
Haemorrhoids 49.65 11.12 323 543388 35349 110010239
Mood swings 49.64 11.12 25 543686 22787 110022801
Lipase increased 49.63 11.12 15 543696 18657 110026931
Enterococcal infection 49.56 11.12 19 543692 20347 110025241
Oesophagitis 49.55 11.12 275 543436 28440 110017148
Hyperammonaemia 49.50 11.12 5 543706 13727 110031861
Respiratory symptom 49.49 11.12 174 543537 14771 110030817
Blood calcium decreased 49.47 11.12 62 543649 35783 110009805
Acne 49.46 11.12 55 543656 33465 110012123
Inappropriate antidiuretic hormone secretion 49.44 11.12 56 543655 33795 110011793
BK virus infection 49.32 11.12 4 543707 13102 110032486
Mental impairment 48.98 11.12 25 543686 22614 110022974
Staphylococcal bacteraemia 48.95 11.12 11 543700 16677 110028911
Electrocardiogram QRS complex prolonged 48.93 11.12 4 543707 13017 110032571
Seborrhoeic keratosis 48.88 11.12 69 543642 3123 110042465
Delusion 48.81 11.12 28 543683 23727 110021861
Tardive dyskinesia 48.81 11.12 5 543706 13574 110032014
Peritonitis 48.66 11.12 53 543658 32554 110013034
Gingival bleeding 48.59 11.12 210 543501 19629 110025959
Motor dysfunction 48.41 11.12 30 543681 24376 110021212
Hypertensive crisis 48.29 11.12 30 543681 24342 110021246
Drug dose omission by device 48.12 11.12 7 543704 14509 110031079
Pulmonary haemorrhage 47.96 11.12 11 543700 16445 110029143
Barrett's oesophagus 47.85 11.12 34 543677 654 110044934
Vaginal flatulence 47.74 11.12 3 543708 12141 110033447
Cataract 47.66 11.12 599 543112 78886 109966702
Purulence 47.59 11.12 58 543653 2269 110043319
Heavy menstrual bleeding 47.57 11.12 11 543700 16354 110029234
Haemodialysis 47.53 11.12 14 543697 17705 110027883
Hair follicle tumour benign 47.48 11.12 29 543682 427 110045161
Tunnel vision 47.48 11.12 54 543657 1961 110043627
Sensory loss 47.47 11.12 23 543688 21434 110024154
Bronchopulmonary aspergillosis 47.44 11.12 46 543665 29817 110015771
Leukocytosis 47.42 11.12 123 543588 53705 109991883
Coordination abnormal 47.35 11.12 33 543678 25195 110020393
Vertebral foraminal stenosis 47.12 11.12 45 543666 1328 110044260
Eustachian tube dysfunction 47.06 11.12 34 543677 672 110044916
Lymphopenia 47.05 11.12 78 543633 40092 110005496
Red cell distribution width increased 47.04 11.12 14 543697 17588 110028000
Lung neoplasm 47.01 11.12 115 543596 7961 110037627
Burning sensation 46.96 11.12 178 543533 69034 109976554
Device occlusion 46.62 11.12 9 543702 15176 110030412
Dialysis 46.59 11.12 19 543692 19600 110025988
Swollen tongue 46.52 11.12 147 543564 60215 109985373
Diabetes mellitus 46.32 11.12 292 543419 99089 109946499
Intervertebral disc protrusion 46.30 11.12 263 543448 27435 110018153
Sinus tachycardia 46.22 11.12 93 543618 44400 110001188
Skin toxicity 46.05 11.12 3 543708 11780 110033808
Cytomegalovirus viraemia 45.92 11.12 15 543696 17749 110027839
Ileus 45.80 11.12 50 543661 30679 110014909
Balance disorder 45.75 11.12 360 543351 116200 109929388
Myelodysplastic syndrome 45.58 11.12 71 543640 37413 110008175
Product storage error 45.52 11.12 25 543686 21703 110023885
Peripheral sensory neuropathy 45.07 11.12 13 543698 16667 110028921
Left ventricular dysfunction 45.07 11.12 30 543681 23463 110022125
Spondylitis 44.67 11.12 140 543571 11198 110034390
Speech disorder 44.65 11.12 154 543557 61415 109984173
Mixed liver injury 44.60 11.12 4 543707 12075 110033513
Rash papular 44.58 11.12 42 543669 27597 110017991
Lip swelling 44.46 11.12 116 543595 50551 109995037
Pulmonary congestion 44.39 11.12 52 543659 30914 110014674
Parkinsonism 44.39 11.12 27 543684 22160 110023428
Drug dependence 44.29 11.12 114 543597 49906 109995682
Pulmonary arterial hypertension 44.26 11.12 57 543654 32511 110013077
Cardiomyopathy 44.20 11.12 60 543651 33465 110012123
Synovial fluid analysis 44.12 11.12 60 543651 2621 110042967
Bone formation decreased 44.12 11.12 18 543693 102 110045486
Trismus 43.92 11.12 99 543612 6497 110039091
Grip strength 43.79 11.12 121 543590 9020 110036568
Blood potassium decreased 43.69 11.12 129 543582 53985 109991603
Loss of employment 43.57 11.12 67 543644 3277 110042311
Hallucination, visual 43.57 11.12 80 543631 39525 110006063
Dysphagia 43.48 11.12 514 543197 153086 109892502
Mania 43.47 11.12 24 543687 20772 110024816
Hypocholesterolaemia 43.46 11.12 97 543614 6324 110039264
Sneezing 43.44 11.12 56 543655 31928 110013660
Blood lactic acid increased 43.36 11.12 12 543699 15809 110029779
Stress cardiomyopathy 43.30 11.12 12 543699 15794 110029794
Pulmonary hypertension 42.89 11.12 134 543577 55086 109990502
Acute pulmonary oedema 42.80 11.12 15 543696 16981 110028607
Hypernatraemia 42.79 11.12 17 543694 17816 110027772
Pneumonia fungal 42.73 11.12 10 543701 14744 110030844
Open reduction of fracture 42.68 11.12 23 543688 263 110045325
Hospitalisation 42.61 11.12 471 543240 142022 109903566
Haemolysis 42.60 11.12 12 543699 15627 110029961
Progressive multifocal leukoencephalopathy 42.56 11.12 36 543675 24920 110020668
Oestrogen deficiency 42.56 11.12 16 543695 70 110045518
Hypocalcaemia 42.50 11.12 171 543540 65195 109980393
Right ventricular failure 42.38 11.12 39 543672 25915 110019673
Dupuytren's contracture 42.34 11.12 13 543698 25 110045563
Photosensitivity reaction 42.32 11.12 38 543673 25551 110020037
Blood albumin decreased 42.32 11.12 44 543667 27608 110017980
Postmenopause 42.30 11.12 14 543697 38 110045550
Intentional dose omission 42.22 11.12 23 543688 20057 110025531
Toothache 42.17 11.12 228 543483 23347 110022241
Swelling face 42.13 11.12 273 543438 92048 109953540
Acquired oesophageal web 42.08 11.12 24 543687 309 110045279
Back disorder 42.04 11.12 209 543502 20713 110024875
Psoriasis 41.76 11.12 463 543248 139530 109906058
Embolism 41.67 11.12 14 543697 16275 110029313
Compression fracture 41.52 11.12 120 543591 9179 110036409
Cyanosis 41.51 11.12 51 543660 29690 110015898
Scleritis 41.41 11.12 86 543625 5334 110040254
Back pain 41.40 11.12 1450 542261 369546 109676042
Substance abuse 41.34 11.12 6 543705 12457 110033131
Escherichia infection 41.05 11.12 34 543677 23782 110021806
Catatonia 41.03 11.12 4 543707 11296 110034292
Internal fixation of fracture 40.95 11.12 28 543683 505 110045083
Breast calcifications 40.90 11.12 36 543675 954 110044634
Respiratory acidosis 40.78 11.12 9 543702 13817 110031771
Morton's neuralgia 40.46 11.12 13 543698 31 110045557
Bradyphrenia 40.44 11.12 5 543706 11723 110033865
Joint destruction 40.28 11.12 132 543579 10811 110034777
Tongue disorder 40.26 11.12 158 543553 14140 110031448
Hepatomegaly 40.20 11.12 28 543683 21386 110024202
Small intestinal obstruction 40.15 11.12 60 543651 32153 110013435
Haemorrhage intracranial 40.09 11.12 50 543661 28919 110016669
Thoracic vertebral fracture 40.06 11.12 96 543615 6559 110039029
Pneumothorax 39.96 11.12 70 543641 35215 110010373
Central nervous system mass 39.92 11.12 33 543678 801 110044787
Angina pectoris 39.86 11.12 164 543547 62131 109983457
Wall motion score index abnormal 39.68 11.12 33 543678 808 110044780
Conjunctivitis allergic 39.60 11.12 98 543613 6833 110038755
Blood potassium increased 39.46 11.12 64 543647 33185 110012403
Kidney transplant rejection 39.23 11.12 6 543705 11981 110033607
Emotional distress 39.11 11.12 103 543608 44744 110000844
Toxic encephalopathy 39.06 11.12 13 543698 15201 110030387
Device related infection 39.03 11.12 85 543626 39434 110006154
Acute sinusitis 39.02 11.12 82 543629 5129 110040459
Hyperaesthesia 38.84 11.12 12 543699 14715 110030873
Iliotibial band syndrome 38.62 11.12 15 543696 73 110045515
Metastases to bone 38.55 11.12 59 543652 31313 110014275
Gangrene 38.53 11.12 16 543695 16325 110029263
Anger 38.21 11.12 23 543688 18984 110026604
Staphylococcal sepsis 38.17 11.12 19 543692 17435 110028153
Needle issue 38.15 11.12 20 543691 17820 110027768
Dermatitis acneiform 37.98 11.12 8 543703 12687 110032901
Injection site warmth 37.98 11.12 19 543692 17386 110028202
Pain of skin 37.85 11.12 26 543685 20003 110025585
SARS-CoV-2 test positive 37.70 11.12 18 543693 16917 110028671
Bladder pain 37.68 11.12 57 543654 2748 110042840
Skeletal injury 37.64 11.12 42 543669 1493 110044095
Lung neoplasm malignant 37.55 11.12 68 543643 33774 110011814
Systemic inflammatory response syndrome 37.46 11.12 9 543702 13034 110032554
Enteritis 37.37 11.12 24 543687 19132 110026456
Subarachnoid haemorrhage 37.33 11.12 55 543656 29647 110015941
Thyroid neoplasm 37.33 11.12 62 543649 3239 110042349
Fracture 37.33 11.12 229 543482 24559 110021029
Normal newborn 37.32 11.12 209 543502 21687 110023901
Ear infection 37.29 11.12 472 543239 62260 109983328
Epstein-Barr virus infection 37.21 11.12 23 543688 18715 110026873
Dermatitis exfoliative generalised 37.05 11.12 5 543706 10967 110034621
Vaginal discharge 36.95 11.12 21 543690 17887 110027701
Petechiae 36.95 11.12 36 543675 23281 110022307
Bruxism 36.71 11.12 78 543633 4916 110040672
Atrial flutter 36.69 11.12 39 543672 24223 110021365
Apathy 36.55 11.12 17 543694 16222 110029366
Generalised oedema 36.54 11.12 59 543652 30645 110014943
Drug level decreased 36.51 11.12 23 543688 18525 110027063
Airway remodelling 36.43 11.12 33 543678 909 110044679
Therapeutic response unexpected 36.42 11.12 38 543673 23805 110021783
Subdural haematoma 36.34 11.12 78 543633 36376 110009212
Acute coronary syndrome 36.26 11.12 36 543675 23076 110022512
Abdominal pain lower 36.16 11.12 81 543630 37202 110008386
Parosmia 36.12 11.12 10 543701 13170 110032418
Vaginal haemorrhage 36.06 11.12 42 543669 25032 110020556
Oesophageal stenosis 36.06 11.12 79 543632 5086 110040502
Sudden death 36.02 11.12 40 543671 24355 110021233
Jaundice 36.02 11.12 159 543552 59077 109986511
Retching 35.96 11.12 35 543676 22647 110022941
Nail operation 35.92 11.12 43 543668 1651 110043937
Comminuted fracture 35.82 11.12 28 543683 626 110044962
Injection site urticaria 35.79 11.12 20 543691 17195 110028393
Sickle cell anaemia with crisis 35.68 11.12 3 543708 9542 110036046
Glycosylated haemoglobin increased 35.68 11.12 38 543673 23581 110022007
Diabetes mellitus inadequate control 35.63 11.12 57 543654 29718 110015870
Lung opacity 35.57 11.12 7 543704 11645 110033943
Hyperphosphataemia 35.57 11.12 18 543693 16363 110029225
Dental alveolar anomaly 35.54 11.12 11 543700 22 110045566
Ventricular arrhythmia 35.52 11.12 4 543707 10083 110035505
Mastication disorder 35.48 11.12 63 543648 3475 110042113
Lacrimation increased 35.41 11.12 61 543650 30889 110014699
Varicose vein 35.38 11.12 94 543617 6846 110038742
Cervicobrachial syndrome 35.21 11.12 36 543675 1156 110044432
Spinal disorder 34.99 11.12 132 543579 11596 110033992
Food allergy 34.98 11.12 28 543683 19920 110025668
Presyncope 34.97 11.12 123 543588 48764 109996824
Acetabulum fracture 34.92 11.12 33 543678 961 110044627
Acute generalised exanthematous pustulosis 34.85 11.12 33 543678 21631 110023957
Intestinal perforation 34.76 11.12 31 543680 20913 110024675
Carpal tunnel syndrome 34.76 11.12 210 543501 22400 110023188
Osteomyelitis acute 34.75 11.12 27 543684 598 110044990
Personality disorder 34.69 11.12 10 543701 12827 110032761
Postmenopausal haemorrhage 34.53 11.12 44 543667 1802 110043786
Enthesopathy 34.42 11.12 137 543574 12341 110033247
Dissociation 34.42 11.12 4 543707 9838 110035750
Eye swelling 34.39 11.12 69 543642 32979 110012609
Lumbar vertebral fracture 34.38 11.12 111 543600 9020 110036568
Bone fistula 34.36 11.12 14 543697 79 110045509
Partial seizures 34.27 11.12 7 543704 11342 110034246
Raynaud's phenomenon 34.11 11.12 32 543679 923 110044665
Hyperthyroidism 34.10 11.12 57 543654 29204 110016384
Carotid artery disease 33.96 11.12 48 543663 2175 110043413
Aspartate aminotransferase increased 33.95 11.12 567 543144 159369 109886219
Cystitis haemorrhagic 33.95 11.12 9 543702 12200 110033388
Mental disorder 33.89 11.12 89 543622 38702 110006886
Anaemia of chronic disease 33.76 11.12 59 543652 3213 110042375
Brain injury 33.75 11.12 12 543699 13464 110032124
Sputum culture positive 33.66 11.12 65 543646 3824 110041764
Drug level below therapeutic 33.63 11.12 8 543703 11665 110033923
Device use error 33.58 11.12 3 543708 9086 110036502
Flatulence 33.54 11.12 137 543574 52012 109993576
Haemolytic anaemia 33.50 11.12 32 543679 20888 110024700
Cardiac septal defect 33.38 11.12 32 543679 949 110044639
Hepatitis acute 33.34 11.12 26 543685 18740 110026848
Hypovolaemic shock 33.23 11.12 15 543696 14568 110031020
Rheumatoid arthritis 33.19 11.12 1172 542539 298441 109747147
Osteomalacia 33.18 11.12 40 543671 1547 110044041
Bronchial secretion retention 33.00 11.12 75 543636 4949 110040639
Hepatitis cholestatic 32.94 11.12 23 543688 17543 110028045
Dementia Alzheimer's type 32.93 11.12 31 543680 898 110044690
Surgery 32.90 11.12 99 543612 41184 110004404
Purpura 32.81 11.12 43 543668 24345 110021243
Melaena 32.57 11.12 201 543510 68556 109977032
Central nervous system lesion 32.43 11.12 18 543693 15535 110030053
Patella fracture 32.17 11.12 49 543662 2377 110043211
Mite allergy 32.06 11.12 81 543630 5722 110039866
Neuralgia 32.04 11.12 126 543585 48352 109997236
Clonus 31.88 11.12 3 543708 8713 110036875
Ovarian disorder 31.75 11.12 25 543686 565 110045023
Uterine prolapse 31.74 11.12 31 543680 941 110044647
Dysstasia 31.72 11.12 72 543639 32914 110012674
Arteriosclerosis coronary artery 31.70 11.12 222 543489 24896 110020692
Crying 31.68 11.12 48 543663 25580 110020008
Amenorrhoea 31.67 11.12 4 543707 9227 110036361
Feeding disorder 31.57 11.12 35 543676 21327 110024261
Bradypnoea 31.57 11.12 3 543708 8646 110036942
Blood magnesium decreased 31.54 11.12 31 543680 19965 110025623
Arterial occlusive disease 31.51 11.12 18 543693 15290 110030298
Lumbosacral radiculopathy 31.49 11.12 25 543686 572 110045016
Device leakage 31.45 11.12 20 543691 16028 110029560
Loss of personal independence in daily activities 31.44 11.12 963 542748 149057 109896531
Hospice care 31.43 11.12 11 543700 12462 110033126
Bladder cancer 31.38 11.12 32 543679 20260 110025328
Pharyngeal swelling 31.38 11.12 10 543701 12022 110033566
Steroid therapy 31.38 11.12 14 543697 102 110045486
Pulseless electrical activity 31.34 11.12 22 543689 16735 110028853
Respiratory syncytial virus infection 31.32 11.12 16 543695 14468 110031120
Peripheral coldness 31.31 11.12 27 543684 18513 110027075
Alanine aminotransferase abnormal 31.19 11.12 109 543602 9225 110036363
Product dispensing error 31.18 11.12 21 543690 16324 110029264
Sinus bradycardia 31.16 11.12 61 543650 29422 110016166
Splenomegaly 31.15 11.12 45 543666 24453 110021135
Colorectal cancer 31.15 11.12 4 543707 9110 110036478
Encephalitis 31.13 11.12 28 543683 18811 110026777
Gout 31.11 11.12 85 543626 36481 110009107
Acidosis 31.07 11.12 39 543672 22492 110023096
Vertigo 31.05 11.12 275 543436 86595 109958993
Polyuria 30.98 11.12 25 543686 17713 110027875
Haematoma 30.89 11.12 165 543546 58311 109987277
Aplasia pure red cell 30.88 11.12 5 543706 9573 110036015
Obstructive airways disorder 30.82 11.12 355 543356 45794 109999794
Injection site rash 30.79 11.12 42 543669 23377 110022211
Hot flush 30.78 11.12 194 543517 65842 109979746
Atopy 30.78 11.12 33 543678 1121 110044467
Blood pressure abnormal 30.73 11.12 39 543672 22385 110023203
Gingival abscess 30.62 11.12 32 543679 1055 110044533
Cold sweat 30.52 11.12 38 543673 21993 110023595
Hypopnoea 30.51 11.12 9 543702 11371 110034217
Swollen joint count 30.48 11.12 103 543608 8571 110037017
Benign neoplasm of skin 30.46 11.12 15 543696 140 110045448
Vaginal disorder 30.36 11.12 23 543688 490 110045098
Antineutrophil cytoplasmic antibody positive 30.31 11.12 73 543638 5003 110040585
Dust allergy 30.31 11.12 81 543630 5920 110039668
Bone formation increased 30.01 11.12 12 543699 64 110045524
Immune thrombocytopenia 29.92 11.12 40 543671 22454 110023134
Paralysis 29.82 11.12 20 543691 15580 110030008
Subcutaneous drug absorption impaired 29.65 11.12 94 543617 7565 110038023
Faeces discoloured 29.58 11.12 78 543633 33870 110011718
Diplopia 29.57 11.12 106 543605 41788 110003800
Hepatic enzyme 29.50 11.12 73 543638 5090 110040498
Prostate cancer 29.48 11.12 91 543620 37550 110008038
Hypophosphatasia 29.45 11.12 14 543697 120 110045468
Multiple sclerosis 29.08 11.12 51 543660 25647 110019941
Heparin-induced thrombocytopenia 28.91 11.12 10 543701 11414 110034174
Joint stiffness 28.86 11.12 478 543233 66765 109978823
Wrong product administered 28.78 11.12 9 543702 10951 110034637
Product administered to patient of inappropriate age 28.78 11.12 3 543708 8033 110037555
Multiple drug therapy 28.68 11.12 3 543708 8011 110037577
Dysphonia 28.64 11.12 237 543474 75692 109969896
Blood test abnormal 28.55 11.12 61 543650 28493 110017095
Pneumatosis intestinalis 28.54 11.12 4 543707 8525 110037063
Therapy change 28.51 11.12 7 543704 9990 110035598
Hypogammaglobulinaemia 28.47 11.12 34 543677 20042 110025546
Hiccups 28.16 11.12 14 543697 12855 110032733
Jaw fistula 28.13 11.12 14 543697 134 110045454
X-ray of pelvis and hip abnormal 28.12 11.12 8 543703 10 110045578
Traumatic ulcer 28.11 11.12 13 543698 104 110045484
Anal abscess 28.08 11.12 11 543700 11627 110033961
Hepatocellular carcinoma 28.02 11.12 7 543704 9873 110035715
Malocclusion 27.99 11.12 16 543695 207 110045381
Treatment noncompliance 27.91 11.12 227 543484 72763 109972825
Enterocele 27.91 11.12 10 543701 37 110045551
Kidney infection 27.90 11.12 52 543659 25547 110020041
Erectile dysfunction 27.87 11.12 30 543681 18526 110027062
Haemoptysis 27.71 11.12 221 543490 71133 109974455
Pharyngeal oedema 27.65 11.12 24 543687 16404 110029184
Product use in unapproved indication 27.44 11.12 1862 541849 445515 109600073
Cardiac failure chronic 27.36 11.12 17 543694 13794 110031794
Renal cancer 27.30 11.12 15 543696 13019 110032569
Skin plaque 27.30 11.12 14 543697 12631 110032957
Drug effective for unapproved indication 27.30 11.12 18 543693 14149 110031439
Serum ferritin increased 27.29 11.12 12 543699 11835 110033753
Ketoacidosis 27.00 11.12 8 543703 10079 110035509
Menopausal symptoms 26.99 11.12 46 543665 2455 110043133
Gingival swelling 26.98 11.12 72 543639 5258 110040330
Prothrombin time prolonged 26.95 11.12 27 543684 17234 110028354
Urge incontinence 26.90 11.12 34 543677 1381 110044207
Wound complication 26.90 11.12 79 543632 6098 110039490
Bronchospasm 26.71 11.12 69 543642 30170 110015418
Anhedonia 26.62 11.12 22 543689 15406 110030182
Fall 26.61 11.12 3372 540339 600110 109445478
Sinus congestion 26.52 11.12 70 543641 30389 110015199
Myalgia 26.46 11.12 862 542849 221519 109824069
Initial insomnia 26.45 11.12 9 543702 10380 110035208
Blood sodium decreased 26.35 11.12 98 543613 38221 110007367
Increased appetite 26.29 11.12 21 543690 14956 110030632
Nocardiosis 26.29 11.12 3 543708 7483 110038105
Abortion induced 26.27 11.12 4 543707 8015 110037573
Mammogram abnormal 26.20 11.12 22 543689 546 110045042
Oral candidiasis 26.10 11.12 122 543589 44638 110000950
Drug specific antibody present 25.89 11.12 5 543706 8429 110037159
Gestational diabetes 25.85 11.12 3 543708 7386 110038202
Peripheral ischaemia 25.79 11.12 11 543700 11047 110034541
Insurance issue 25.66 11.12 10 543701 10602 110034986
Blindness 25.66 11.12 92 543619 36267 110009321
Immune-mediated enterocolitis 25.63 11.12 9 543702 10176 110035412
Intestinal ischaemia 25.61 11.12 25 543686 16154 110029434
Catarrh 25.60 11.12 3 543708 7332 110038256
Hepatitis C 25.58 11.12 15 543696 12558 110033030
Drug effect less than expected 25.54 11.12 3 543708 7317 110038271
Euphoric mood 25.53 11.12 6 543705 8821 110036767
Ear congestion 25.52 11.12 56 543655 3609 110041979
Coma scale abnormal 25.52 11.12 8 543703 9718 110035870
Peptic ulcer 25.48 11.12 89 543622 7530 110038058
Thalassaemia beta 25.42 11.12 7 543704 7 110045581
Bone graft 25.36 11.12 25 543686 768 110044820
Psychiatric symptom 25.23 11.12 7 543704 9206 110036382
Capillaritis 25.19 11.12 44 543667 2395 110043193
Leukoencephalopathy 25.15 11.12 7 543704 9188 110036400
Product preparation error 25.09 11.12 11 543700 10868 110034720
Exposure via skin contact 24.93 11.12 17 543694 13130 110032458
Ankle fracture 24.92 11.12 175 543536 19644 110025944
Euglycaemic diabetic ketoacidosis 24.90 11.12 13 543698 11610 110033978
Systemic candida 24.78 11.12 9 543702 9965 110035623
Drug level above therapeutic 24.77 11.12 13 543698 11575 110034013
Spondylolysis 24.73 11.12 15 543696 218 110045370
Nystagmus 24.72 11.12 13 543698 11564 110034024
Adenoidal disorder 24.67 11.12 15 543696 219 110045369
Long QT syndrome 24.63 11.12 3 543708 7115 110038473
Hereditary angioedema 24.61 11.12 3 543708 7111 110038477
Hepatic necrosis 24.57 11.12 9 543702 9913 110035675
Atrioventricular block 24.56 11.12 28 543683 16849 110028739
Blood pressure fluctuation 24.54 11.12 242 543469 74582 109971006
Pseudomonal sepsis 24.53 11.12 7 543704 9039 110036549
Dermatitis bullous 24.53 11.12 30 543681 17499 110028089
Poor dental condition 24.50 11.12 23 543688 664 110044924
Intervertebral disc disorder 24.49 11.12 71 543640 5441 110040147
Tooth infection 24.42 11.12 190 543521 22026 110023562
Tooth resorption 24.38 11.12 9 543702 37 110045551
Cytomegalovirus colitis 24.37 11.12 3 543708 7058 110038530
Peripheral vascular disorder 24.34 11.12 95 543616 8481 110037107
Salivary hypersecretion 24.18 11.12 30 543681 17391 110028197
Extraskeletal ossification 24.10 11.12 12 543699 115 110045473
Personality change 24.02 11.12 12 543699 10990 110034598
Parainfluenzae virus infection 23.98 11.12 3 543708 6971 110038617
Proctalgia 23.89 11.12 18 543693 13204 110032384
Cholangitis 23.88 11.12 27 543684 16308 110029280
Fracture malunion 23.83 11.12 12 543699 118 110045470
Oesophageal disorder 23.80 11.12 49 543662 3021 110042567
Peritonitis bacterial 23.75 11.12 11 543700 10522 110035066
Hypoxic-ischaemic encephalopathy 23.71 11.12 7 543704 8840 110036748
Injection site discomfort 23.68 11.12 3 543708 6904 110038684
Renal tubular disorder 23.68 11.12 4 543707 7425 110038163
Complication of device insertion 23.67 11.12 7 543704 8831 110036757
Metabolic disorder 23.66 11.12 11 543700 10499 110035089
Pulse absent 23.65 11.12 13 543698 11279 110034309
Pulmonary thrombosis 23.64 11.12 20 543691 13843 110031745
Clostridium test positive 23.61 11.12 12 543699 10881 110034707
Atrophy 23.59 11.12 43 543668 2421 110043167
Urosepsis 23.43 11.12 75 543636 30600 110014988
Transplant dysfunction 23.42 11.12 6 543705 8322 110037266
Bacterial sepsis 23.33 11.12 11 543700 10415 110035173
Methaemoglobinaemia 23.25 11.12 8 543703 9160 110036428
Tuberculosis 23.24 11.12 32 543679 17742 110027846
Adjustment disorder 23.23 11.12 12 543699 10783 110034805
Stupor 23.16 11.12 6 543705 8259 110037329
Pneumonia bacterial 23.14 11.12 60 543651 26201 110019387
Productive cough 23.04 11.12 409 543302 113896 109931692
Guillain-Barre syndrome 23.04 11.12 12 543699 10732 110034856
Arteriosclerosis 23.04 11.12 204 543507 24563 110021025
Spinal meningeal cyst 22.99 11.12 12 543699 128 110045460
Protein urine present 22.94 11.12 14 543697 11470 110034118
Metastases to lymph nodes 22.91 11.12 24 543687 15008 110030580
Genital haemorrhage 22.91 11.12 4 543707 7248 110038340
Immune-mediated hepatitis 22.80 11.12 3 543708 6708 110038880
Breast cyst 22.77 11.12 32 543679 1442 110044146
Disability 22.71 11.12 238 543473 29985 110015603
Extra dose administered 22.69 11.12 16 543695 12143 110033445
Paraesthesia 22.69 11.12 1615 542096 274906 109770682
Scab 22.69 11.12 19 543692 13217 110032371
Amylase increased 22.68 11.12 17 543694 12502 110033086
Mouth cyst 22.66 11.12 9 543702 47 110045541
Spinal stenosis 22.65 11.12 166 543545 18890 110026698
Lip neoplasm 22.62 11.12 7 543704 14 110045574
Otitis externa 22.61 11.12 45 543666 2707 110042881
Injection site induration 22.57 11.12 14 543697 11369 110034219
Dermal cyst 22.55 11.12 49 543662 3137 110042451
Nocturia 22.53 11.12 152 543559 16838 110028750
Ankle arthroplasty 22.52 11.12 43 543668 2508 110043080
Faecaloma 22.50 11.12 24 543687 14884 110030704
Aortic arteriosclerosis 22.50 11.12 110 543601 10828 110034760
Drug eruption 22.50 11.12 380 543331 53279 109992309
Cardiac disorder 22.46 11.12 253 543458 76027 109969561
Neoplasm skin 22.36 11.12 49 543662 3155 110042433
Injection site extravasation 22.34 11.12 11 543700 10158 110035430
Abnormal dreams 22.33 11.12 18 543693 12762 110032826
Cardiac tamponade 22.29 11.12 14 543697 11293 110034295
Dysuria 22.27 11.12 189 543522 60042 109985546
Product administration interrupted 22.23 11.12 14 543697 11278 110034310
Human herpesvirus 6 infection 22.22 11.12 3 543708 6578 110039010
Diabetes insipidus 22.17 11.12 3 543708 6567 110039021
Hypercalciuria 22.17 11.12 20 543691 548 110045040
Granulocytopenia 22.11 11.12 18 543693 12697 110032891
Goitre 22.09 11.12 74 543637 6130 110039458
Psychomotor skills impaired 22.06 11.12 4 543707 7054 110038534
Infective pulmonary exacerbation of cystic fibrosis 22.05 11.12 24 543687 14747 110030841
Catheter site infection 22.05 11.12 6 543705 7994 110037594
Infusion site erythema 21.97 11.12 16 543695 11943 110033645
Haematuria 21.88 11.12 282 543429 82723 109962865
Intervertebral discitis 21.76 11.12 4 543707 6986 110038602
Bradykinesia 21.76 11.12 13 543698 10775 110034813
Hepatic cancer 21.73 11.12 14 543697 11142 110034446
Odontogenic cyst 21.70 11.12 7 543704 17 110045571
Complications of transplanted kidney 21.64 11.12 5 543706 7437 110038151
Spinal pain 21.64 11.12 36 543675 18479 110027109
Pharyngitis streptococcal 21.62 11.12 20 543691 13257 110032331
Hormone therapy 21.60 11.12 5 543706 0 110045588
Expired product administered 21.55 11.12 7 543704 8313 110037275
Osteopetrosis 21.50 11.12 9 543702 55 110045533
Bladder disorder 21.50 11.12 110 543601 11027 110034561
Neutrophilia 21.47 11.12 12 543699 10317 110035271
Coronavirus infection 21.47 11.12 10 543701 9535 110036053
Blood creatinine decreased 21.45 11.12 9 543702 9128 110036460
Renal cyst 21.43 11.12 158 543553 18014 110027574
Wrong technique in device usage process 21.38 11.12 4 543707 6897 110038691
Cholestatic liver injury 21.36 11.12 5 543706 7371 110038217
Cholelithiasis 21.27 11.12 204 543507 63218 109982370
Tooth impacted 21.27 11.12 15 543696 285 110045303
Fear 21.20 11.12 52 543659 23141 110022447
Humerus fracture 21.19 11.12 107 543604 10669 110034919
Thirst 21.18 11.12 47 543664 21660 110023928
Gastritis 20.98 11.12 376 543335 53323 109992265
Hypertransaminasaemia 20.93 11.12 56 543655 24199 110021389
Chromaturia 20.91 11.12 74 543637 29286 110016302
Performance status decreased 20.89 11.12 5 543706 7261 110038327
Vascular calcification 20.87 11.12 27 543684 1123 110044465
Delirium 20.87 11.12 837 542874 134188 109911400
Localised infection 20.83 11.12 125 543586 42923 110002665
Cancer pain 20.82 11.12 4 543707 6768 110038820
Hepatitis fulminant 20.80 11.12 8 543703 8552 110037036
Sexual dysfunction 20.69 11.12 8 543703 8522 110037066
Cardiac dysfunction 20.63 11.12 3 543708 6220 110039368
Chondromalacia 20.55 11.12 12 543699 162 110045426
Hyperpyrexia 20.53 11.12 7 543704 8062 110037526
Anal fistula 20.46 11.12 8 543703 8465 110037123
Dizziness postural 20.44 11.12 25 543686 14584 110031004
Jaundice cholestatic 20.44 11.12 25 543686 14583 110031005
Pneumonia viral 20.41 11.12 15 543696 11142 110034446
Traumatic fracture 20.36 11.12 27 543684 1151 110044437
Total lung capacity decreased 20.25 11.12 5 543706 7109 110038479
Abdominal abscess 20.21 11.12 9 543702 8810 110036778
Polyarthritis 20.19 11.12 161 543550 18802 110026786
N-terminal prohormone brain natriuretic peptide increased 20.18 11.12 3 543708 6118 110039470
Sleep terror 20.12 11.12 4 543707 6606 110038982
Rash pustular 20.10 11.12 20 543691 12809 110032779
Erysipelas 20.07 11.12 21 543690 13137 110032451
Anosmia 20.06 11.12 19 543692 12453 110033135
Osteogenesis imperfecta 20.06 11.12 22 543689 767 110044821
Urethral caruncle 20.01 11.12 9 543702 67 110045521
Foetal exposure during pregnancy 20.00 11.12 6 543705 7499 110038089
Electrocardiogram ST segment elevation 19.99 11.12 10 543701 9150 110036438
Hypotonia 19.94 11.12 29 543682 15716 110029872
Pulmonary tuberculosis 19.91 11.12 10 543701 9129 110036459
Bedridden 19.84 11.12 22 543689 13403 110032185
Catheter site erythema 19.77 11.12 3 543708 6025 110039563
Endocarditis 19.66 11.12 22 543689 13349 110032239
Pneumonia cytomegaloviral 19.58 11.12 5 543706 6949 110038639
Ammonia increased 19.58 11.12 8 543703 8242 110037346
Mixed incontinence 19.57 11.12 9 543702 71 110045517
Procedural pain 19.55 11.12 99 543612 35466 110010122
Laryngeal ulceration 19.53 11.12 11 543700 138 110045450
Eyelid oedema 19.44 11.12 28 543683 15234 110030354
Tonsillitis 19.43 11.12 8 543703 8205 110037383
Joint injury 19.32 11.12 290 543421 39704 110005884
Dental prosthesis user 19.31 11.12 7 543704 27 110045561
Neurological decompensation 19.28 11.12 5 543706 6878 110038710
Groin pain 19.26 11.12 136 543575 15292 110030296
Wound secretion 19.22 11.12 76 543635 6825 110038763
Hypercapnia 19.15 11.12 16 543695 11143 110034445
Aspiration 19.15 11.12 81 543630 30452 110015136
Gingival ulceration 19.11 11.12 27 543684 1223 110044365
Pancreatitis 19.07 11.12 334 543377 93199 109952389
Tinnitus 18.94 11.12 198 543513 60342 109985246
Melanocytic naevus 18.87 11.12 66 543645 5588 110040000
Iron deficiency 18.87 11.12 39 543672 18437 110027151
Brain abscess 18.82 11.12 5 543706 6769 110038819
Metabolic encephalopathy 18.80 11.12 16 543695 11044 110034544
Areflexia 18.80 11.12 5 543706 6764 110038824
Intermittent claudication 18.74 11.12 50 543661 3651 110041937
Thermohypoaesthesia 18.74 11.12 10 543701 112 110045476
Cell death 18.72 11.12 3 543708 5788 110039800
Leukoplakia 18.68 11.12 12 543699 194 110045394
Cutaneous vasculitis 18.65 11.12 21 543690 12708 110032880
Acute lymphocytic leukaemia 18.61 11.12 3 543708 5762 110039826
General physical condition abnormal 18.60 11.12 7 543704 7583 110038005
Bronchitis chronic 18.55 11.12 60 543651 4880 110040708
Sputum increased 18.55 11.12 3 543708 5748 110039840
Sluggishness 18.51 11.12 7 543704 7560 110038028
Cachexia 18.47 11.12 22 543689 12983 110032605
Hormone level abnormal 18.46 11.12 38 543673 2342 110043246
Lenticular opacities 18.44 11.12 19 543692 616 110044972
Respiratory alkalosis 18.41 11.12 3 543708 5718 110039870
Atrioventricular block complete 18.38 11.12 45 543666 20037 110025551
Salivary gland mass 18.37 11.12 9 543702 83 110045505
Paraplegia 18.36 11.12 4 543707 6196 110039392
Nasal disorder 18.29 11.12 54 543657 4180 110041408
Eosinophilic myocarditis 18.23 11.12 35 543676 2050 110043538
Streptococcal infection 18.22 11.12 16 543695 10874 110034714
Peri-implantitis 18.21 11.12 12 543699 203 110045385
Failure to thrive 18.19 11.12 24 543687 13550 110032038
Congestive cardiomyopathy 18.19 11.12 26 543685 14193 110031395
Neuroma 18.18 11.12 14 543697 306 110045282
Portal vein thrombosis 18.17 11.12 6 543705 7052 110038536
Eye injury 18.16 11.12 81 543630 7674 110037914
Escherichia bacteraemia 18.16 11.12 14 543697 10150 110035438
Demyelination 18.14 11.12 12 543699 9417 110036171
Brain natriuretic peptide increased 18.12 11.12 17 543694 11192 110034396
Injection site haemorrhage 18.12 11.12 92 543619 32936 110012652
Herpes simplex 18.10 11.12 31 543680 15733 110029855
Pseudarthrosis 18.06 11.12 14 543697 309 110045279
Blood creatine increased 18.01 11.12 18 543693 11503 110034085
Poor venous access 18.01 11.12 61 543650 24461 110021127
Portal hypertension 18.00 11.12 10 543701 8627 110036961
Lung consolidation 18.00 11.12 15 543696 10461 110035127
Erythema multiforme 17.98 11.12 49 543662 21048 110024540
Prostatic specific antigen increased 17.94 11.12 21 543690 12490 110033098
Dental pulp disorder 17.94 11.12 6 543705 17 110045571
Middle insomnia 17.94 11.12 47 543664 20455 110025133
Skin irritation 17.92 11.12 33 543678 16286 110029302
Cystitis 17.91 11.12 223 543488 65813 109979775
Medication error 17.91 11.12 660 543051 104706 109940882
Underdose 17.90 11.12 424 543287 63130 109982458
Eye movement disorder 17.89 11.12 13 543698 9715 110035873
Nephropathy 17.86 11.12 24 543687 13443 110032145
Internal haemorrhage 17.83 11.12 14 543697 10057 110035531
Urine output decreased 17.83 11.12 45 543666 19831 110025757
Pruritus genital 17.77 11.12 5 543706 6517 110039071
Supraventricular tachycardia 17.76 11.12 61 543650 24361 110021227
Chemical burn of respiratory tract 17.74 11.12 9 543702 90 110045498
Renal function test abnormal 17.74 11.12 11 543700 8935 110036653
Breast fibrosis 17.69 11.12 6 543705 18 110045570
Oesophageal discomfort 17.68 11.12 17 543694 506 110045082
Hypersensitivity vasculitis 17.68 11.12 6 543705 6931 110038657
Osteitis deformans 17.62 11.12 12 543699 215 110045373
Hepatosplenomegaly 17.61 11.12 6 543705 6913 110038675
Phlebolith 17.61 11.12 11 543700 169 110045419
Therapy non-responder 17.60 11.12 944 542767 156363 109889225
Hypoglycaemic coma 17.59 11.12 3 543708 5530 110040058
Bone cyst 17.56 11.12 48 543663 3555 110042033
Hepatitis B 17.48 11.12 13 543698 9599 110035989
Decreased immune responsiveness 17.46 11.12 13 543698 9593 110035995
Prescription drug used without a prescription 17.43 11.12 3 543708 5493 110040095
Dermatitis exfoliative 17.43 11.12 18 543693 11329 110034259
Subileus 17.42 11.12 5 543706 6432 110039156
Pseudomonas infection 17.40 11.12 74 543637 27779 110017809
Benign prostatic hyperplasia 17.37 11.12 40 543671 18194 110027394
Pancreatic carcinoma 17.30 11.12 29 543682 14843 110030745
Poor quality sleep 17.29 11.12 75 543636 28002 110017586
Uterine cervix atrophy 17.28 11.12 4 543707 0 110045588
Traumatic occlusion 17.28 11.12 4 543707 0 110045588
Device related sepsis 17.22 11.12 8 543703 7639 110037949
Kounis syndrome 17.19 11.12 4 543707 5921 110039667
Product substitution issue 17.18 11.12 57 543654 23004 110022584
Incorrect dose administered by device 17.18 11.12 6 543705 6808 110038780
Overlap syndrome 17.15 11.12 89 543622 8970 110036618
Coronary arterial stent insertion 17.15 11.12 4 543707 5911 110039677
Compartment syndrome 17.13 11.12 4 543707 5906 110039682
Autoimmune haemolytic anaemia 17.11 11.12 16 543695 10551 110035037
Rebound effect 17.11 11.12 29 543682 14777 110030811
Respiratory tract infection viral 16.99 11.12 4 543707 5874 110039714
Faeces soft 16.97 11.12 18 543693 11192 110034396
Haemoperitoneum 16.96 11.12 3 543708 5385 110040203
Paradoxical drug reaction 16.94 11.12 14 543697 9803 110035785
Skin mass 16.94 11.12 14 543697 9802 110035786
Palatal disorder 16.93 11.12 17 543694 534 110045054
Stenotrophomonas infection 16.91 11.12 4 543707 5854 110039734
Rash morbilliform 16.87 11.12 9 543702 7942 110037646
Gastrooesophageal cancer 16.86 11.12 5 543706 8 110045580
Myasthenia gravis 16.85 11.12 52 543659 21459 110024129
General symptom 16.81 11.12 87 543624 8759 110036829
Cytomegalovirus chorioretinitis 16.77 11.12 7 543704 7121 110038467
Oral pain 16.75 11.12 268 543443 37176 110008412
Carcinoid tumour pulmonary 16.69 11.12 15 543696 409 110045179
Respiratory rate decreased 16.68 11.12 5 543706 6253 110039335
Trigger finger 16.62 11.12 59 543652 5033 110040555
Tachyarrhythmia 16.60 11.12 10 543701 8251 110037337
Emotional disorder 16.59 11.12 34 543677 16126 110029462
Tongue oedema 16.58 11.12 10 543701 8246 110037342
Self-medication 16.58 11.12 5 543706 6227 110039361
Plantar fasciitis 16.56 11.12 59 543652 5042 110040546
Post procedural complication 16.54 11.12 71 543640 26587 110019001
Swelling of eyelid 16.54 11.12 6 543705 6647 110038941
Blood culture positive 16.50 11.12 12 543699 8964 110036624
Respiratory tract infection 16.50 11.12 250 543461 71367 109974221
Gastrointestinal perforation 16.48 11.12 8 543703 7448 110038140
Lower gastrointestinal haemorrhage 16.47 11.12 42 543669 18444 110027144
Orthopnoea 16.35 11.12 18 543693 11003 110034585
Hunger 16.34 11.12 6 543705 6598 110038990
Electroencephalogram abnormal 16.33 11.12 5 543706 6168 110039420
Product monitoring error 16.33 11.12 12 543699 8915 110036673
Osteoma 16.33 11.12 9 543702 108 110045480
Head discomfort 16.29 11.12 44 543667 18956 110026632
Neoplasm recurrence 16.28 11.12 3 543708 5229 110040359
Neurosensory hypoacusis 16.28 11.12 12 543699 245 110045343
Tearfulness 16.25 11.12 8 543703 7387 110038201
Actinic keratosis 16.24 11.12 73 543638 6940 110038648
Blood thyroid stimulating hormone increased 16.23 11.12 22 543689 12279 110033309
Thyroiditis 16.21 11.12 6 543705 6567 110039021
Brain death 16.21 11.12 6 543705 6567 110039021
Pericardial haemorrhage 16.21 11.12 3 543708 5214 110040374
Rectal polyp 16.19 11.12 28 543683 1512 110044076
Infusion site extravasation 16.18 11.12 20 543691 11614 110033974
Enterocolitis 16.16 11.12 44 543667 18905 110026683
Blood glucose abnormal 16.15 11.12 24 543687 12892 110032696
Breast mass 16.13 11.12 81 543630 8060 110037528
Anxiety disorder 16.11 11.12 58 543653 4982 110040606
Red blood cells urine positive 16.07 11.12 3 543708 5182 110040406
Intestinal haemorrhage 16.04 11.12 8 543703 7333 110038255
Sleep disorder due to a general medical condition 16.03 11.12 352 543359 51760 109993828
Rheumatoid lung 15.92 11.12 52 543659 4252 110041336
Transient ischaemic attack 15.91 11.12 220 543491 63762 109981826
Cervical polyp 15.91 11.12 12 543699 254 110045334
Injection site haematoma 15.90 11.12 3 543708 5143 110040445
Rhinitis allergic 15.84 11.12 146 543565 17776 110027812
Blood pressure systolic decreased 15.83 11.12 26 543685 13415 110032173
Renal disorder 15.82 11.12 161 543550 49318 109996270
Depressive symptom 15.80 11.12 11 543700 8403 110037185
Liver function test abnormal 15.78 11.12 241 543470 68709 109976879
Grief reaction 15.71 11.12 13 543698 316 110045272
Respiration abnormal 15.71 11.12 15 543696 9794 110035794
Injection site discolouration 15.68 11.12 13 543698 9090 110036498
Pneumonia aspiration 15.64 11.12 293 543418 80940 109964648
Skin laceration 15.63 11.12 243 543468 33510 110012078
Scapula fracture 15.60 11.12 19 543692 743 110044845
Drug-induced liver injury 15.59 11.12 731 542980 119336 109926252
Ocular hyperaemia 15.57 11.12 121 543590 39165 110006423
Breast cancer in situ 15.56 11.12 24 543687 1177 110044411
Coronary artery occlusion 15.51 11.12 34 543677 15738 110029850
Exercise tolerance decreased 15.50 11.12 22 543689 12045 110033543
Increased tendency to bruise 15.48 11.12 105 543606 11653 110033935
Upper limb fracture 15.47 11.12 164 543547 20724 110024864
Immunosuppressant drug level increased 15.44 11.12 21 543690 11703 110033885
Periorbital swelling 15.42 11.12 4 543707 5501 110040087
Pancreatitis necrotising 15.40 11.12 4 543707 5497 110040091
Hypoproteinaemia 15.40 11.12 5 543706 5940 110039648
Complication associated with device 15.38 11.12 49 543662 20024 110025564
Myofascial pain syndrome 15.36 11.12 37 543674 2536 110043052
Pernicious anaemia 15.36 11.12 19 543692 755 110044833
Petit mal epilepsy 15.36 11.12 9 543702 7538 110038050
Autoimmune hepatitis 15.33 11.12 31 543680 14773 110030815
Sinus disorder 15.30 11.12 236 543475 32492 110013096
Sensitivity to weather change 15.30 11.12 16 543695 10012 110035576
Drooling 15.27 11.12 8 543703 7131 110038457
Neurological symptom 15.27 11.12 130 543581 15478 110030110
Eating disorder 15.25 11.12 89 543622 30769 110014819
Blood creatinine abnormal 15.19 11.12 5 543706 5887 110039701
Nerve degeneration 15.14 11.12 12 543699 274 110045314
Cerebellar syndrome 15.13 11.12 6 543705 6296 110039292
Cerebral haematoma 15.11 11.12 15 543696 9617 110035971
Pulmonary pain 15.10 11.12 6 543705 6287 110039301
Anal haemorrhage 15.07 11.12 3 543708 4949 110040639
Skin erosion 15.03 11.12 5 543706 5849 110039739
Uterine leiomyoma 15.03 11.12 77 543634 7723 110037865
Drug abuser 15.02 11.12 4 543707 5405 110040183
Bone atrophy 15.00 11.12 6 543705 32 110045556
Viral infection 14.96 11.12 178 543533 52961 109992627
Product administered at inappropriate site 14.95 11.12 4 543707 5389 110040199
Dry eye 14.91 11.12 189 543522 55604 109989984
Localised oedema 14.89 11.12 14 543697 9209 110036379
Cytomegalovirus test positive 14.88 11.12 8 543703 7028 110038560
Anticoagulant therapy 14.82 11.12 4 543707 5357 110040231
Anal fissure 14.81 11.12 16 543695 9865 110035723
Antipsychotic drug level increased 14.80 11.12 8 543703 7007 110038581
Benign breast neoplasm 14.79 11.12 20 543691 869 110044719
Hydronephrosis 14.77 11.12 52 543659 20613 110024975
Autonomic nervous system imbalance 14.73 11.12 5 543706 5775 110039813
Catheterisation cardiac 14.70 11.12 6 543705 6185 110039403
Dizziness 14.69 11.12 3121 540590 695072 109350516
Liver abscess 14.69 11.12 10 543701 7729 110037859
Blood triglycerides increased 14.68 11.12 64 543647 23862 110021726
Forced expiratory volume decreased 14.66 11.12 113 543598 13063 110032525
Panic reaction 14.65 11.12 4 543707 5318 110040270
Temperature intolerance 14.62 11.12 29 543682 13921 110031667
Uveitis 14.62 11.12 56 543655 21654 110023934
Face injury 14.62 11.12 52 543659 4440 110041148
Skin swelling 14.60 11.12 11 543700 8069 110037519
Immunosuppression 14.58 11.12 42 543669 17717 110027871
Anal incontinence 14.57 11.12 57 543654 21907 110023681
Blood glucose fluctuation 14.54 11.12 10 543701 7688 110037900
JC virus infection 14.52 11.12 4 543707 5286 110040302
Depression suicidal 14.52 11.12 3 543708 4821 110040767
Thrombocytosis 14.48 11.12 18 543693 10426 110035162
Blood pressure diastolic decreased 14.47 11.12 110 543601 35775 110009813
Nephritis 14.44 11.12 6 543705 6120 110039468
Presbyopia 14.44 11.12 18 543693 721 110044867
Prostatitis 14.42 11.12 3 543708 4798 110040790
Menstrual disorder 14.34 11.12 3 543708 4781 110040807
Electrocardiogram T wave inversion 14.33 11.12 5 543706 5675 110039913
Fungaemia 14.28 11.12 6 543705 6080 110039508
Sputum culture 14.15 11.12 12 543699 302 110045286
Oropharyngeal discomfort 14.11 11.12 18 543693 10309 110035279
Carbon dioxide decreased 14.09 11.12 3 543708 4721 110040867
Hyperlactacidaemia 14.07 11.12 12 543699 8274 110037314
Oxygen saturation abnormal 14.05 11.12 5 543706 5606 110039982
Anxiety 14.03 11.12 1919 541792 343159 109702429
Allergy to chemicals 13.98 11.12 42 543669 3283 110042305
Hepatic pain 13.94 11.12 3 543708 4687 110040901
Product availability issue 13.93 11.12 11 543700 7879 110037709
Cardiac operation 13.92 11.12 6 543705 5989 110039599
Hyperparathyroidism primary 13.88 11.12 15 543696 514 110045074
Meniere's disease 13.88 11.12 9 543702 148 110045440
Osteodystrophy 13.85 11.12 5 543706 19 110045569
Trigeminal neuralgia 13.84 11.12 50 543661 4302 110041286
Thinking abnormal 13.80 11.12 34 543677 15106 110030482
Vulvovaginal dryness 13.80 11.12 37 543674 2710 110042878
Vascular headache 13.77 11.12 6 543705 41 110045547
Injection site nodule 13.75 11.12 3 543708 4643 110040945
Blood prolactin increased 13.74 11.12 3 543708 4639 110040949
Asthma-chronic obstructive pulmonary disease overlap syndrome 13.73 11.12 7 543704 6337 110039251
Brain herniation 13.68 11.12 14 543697 8849 110036739
Vaginal dysplasia 13.65 11.12 6 543705 42 110045546
Hepatitis toxic 13.64 11.12 6 543705 5915 110039673
Incorrect drug administration rate 13.63 11.12 5 543706 5503 110040085
Intraventricular haemorrhage 13.63 11.12 5 543706 5502 110040086
Streptococcal sepsis 13.62 11.12 4 543707 5068 110040520
Hepatic lesion 13.59 11.12 13 543698 8480 110037108
Skin disorder 13.57 11.12 140 543571 42773 110002815
Ileus paralytic 13.55 11.12 23 543688 11714 110033874
Refusal of treatment by patient 13.55 11.12 16 543695 9478 110036110
Liver transplant 13.51 11.12 3 543708 4586 110041002
Left ventricular failure 13.44 11.12 22 543689 11367 110034221
Normochromic normocytic anaemia 13.44 11.12 110 543601 12947 110032641
Feeling hot 13.39 11.12 343 543368 90763 109954825
Oesophagitis chemical 13.38 11.12 7 543704 75 110045513
Burns second degree 13.38 11.12 11 543700 7722 110037866
Hypoventilation 13.36 11.12 12 543699 8069 110037519
Staphylococcus test positive 13.36 11.12 10 543701 7360 110038228
Sarcoidosis 13.32 11.12 26 543685 12553 110033035
Potentiating drug interaction 13.27 11.12 23 543688 11620 110033968
Acute psychosis 13.27 11.12 4 543707 4983 110040605
Granuloma 13.25 11.12 86 543625 9404 110036184
Lipodystrophy acquired 13.23 11.12 3 543708 4521 110041067
Benign bone neoplasm 13.20 11.12 8 543703 116 110045472
Large intestine perforation 13.16 11.12 40 543671 16589 110028999
Pemphigoid 13.16 11.12 51 543660 19656 110025932
Sight disability 13.16 11.12 10 543701 214 110045374
Menstruation irregular 13.15 11.12 6 543705 5791 110039797
Intermenstrual bleeding 13.11 11.12 9 543702 6925 110038663
Oral discharge 13.03 11.12 11 543700 275 110045313
Superinfection 13.02 11.12 6 543705 5757 110039831
Death neonatal 12.99 11.12 27 543684 1676 110043912
Deafness traumatic 12.96 11.12 3 543708 0 110045588
External fixation of fracture 12.96 11.12 3 543708 0 110045588
Resorption bone decreased 12.96 11.12 3 543708 0 110045588
Erythroplasia 12.96 11.12 3 543708 0 110045588
Intestinal mucosal tear 12.96 11.12 3 543708 0 110045588
Lipoma of breast 12.96 11.12 3 543708 0 110045588
Bartholin's cyst 12.96 11.12 3 543708 0 110045588
Decreased interest 12.94 11.12 4 543707 4904 110040684
Upper-airway cough syndrome 12.94 11.12 127 543584 15730 110029858
Osteorrhagia 12.93 11.12 4 543707 8 110045580
Joint ankylosis 12.91 11.12 34 543677 2463 110043125
Muscle contractions involuntary 12.89 11.12 3 543708 4441 110041147
Osteocalcin decreased 12.87 11.12 6 543705 49 110045539
Posture abnormal 12.87 11.12 3 543708 4435 110041153
Hyperventilation 12.85 11.12 15 543696 8932 110036656
Spinal fusion surgery 12.80 11.12 83 543628 9073 110036515
Systolic dysfunction 12.77 11.12 3 543708 4412 110041176
Tooth dislocation 12.77 11.12 6 543705 50 110045538
Diffuse large B-cell lymphoma 12.76 11.12 38 543673 15860 110029728
Impaired gastric emptying 12.74 11.12 29 543682 13246 110032342
Periorbital oedema 12.68 11.12 19 543692 10173 110035415
Infarction 12.68 11.12 5 543706 5264 110040324
Meningitis aseptic 12.68 11.12 18 543693 9852 110035736
Angina unstable 12.67 11.12 40 543671 16392 110029196
Plasmacytoma 12.65 11.12 5 543706 5257 110040331
White blood cells urine positive 12.65 11.12 11 543700 7513 110038075
Nephrotic syndrome 12.65 11.12 31 543680 13800 110031788
Terminal state 12.65 11.12 6 543705 5661 110039927
Colectomy 12.61 11.12 3 543708 4375 110041213
Tumour haemorrhage 12.59 11.12 5 543706 5240 110040348
Atrial tachycardia 12.54 11.12 16 543695 9162 110036426
Acrochordon 12.50 11.12 24 543687 1406 110044182
Gastrointestinal sounds abnormal 12.50 11.12 7 543704 6011 110039577
Mandibular mass 12.44 11.12 10 543701 233 110045355
Application site erythema 12.43 11.12 6 543705 5604 110039984
Sialoadenitis 12.43 11.12 35 543676 2638 110042950
Rales 12.41 11.12 71 543640 24668 110020920
Blood chloride increased 12.41 11.12 8 543703 6364 110039224
Varicella zoster virus infection 12.39 11.12 8 543703 6360 110039228
Breath odour 12.28 11.12 29 543682 1963 110043625
Papilloedema 12.26 11.12 11 543700 7398 110038190
Decreased activity 12.22 11.12 22 543689 10952 110034636
Diverticulum intestinal 12.21 11.12 99 543612 11620 110033968
Defaecation urgency 12.21 11.12 15 543696 8732 110036856
Hiatus hernia strangulated 12.21 11.12 11 543700 301 110045287
Poliomyelitis 12.18 11.12 6 543705 56 110045532
Chronic myeloid leukaemia 12.17 11.12 3 543708 4270 110041318
Breast cancer female 12.16 11.12 27 543684 12441 110033147
Renal tubular acidosis 12.15 11.12 4 543707 4711 110040877
Abdominal tenderness 12.13 11.12 27 543684 12430 110033158
Type 1 diabetes mellitus 12.12 11.12 16 543695 9031 110036557
Pulmonary arterial pressure increased 12.12 11.12 5 543706 5122 110040466
Diarrhoea haemorrhagic 12.11 11.12 38 543673 15601 110029987
Gastric haemorrhage 12.09 11.12 39 543672 15876 110029712
Tooth discolouration 12.07 11.12 23 543688 1340 110044248
Livedo reticularis 12.03 11.12 6 543705 5500 110040088
Tympanic membrane perforation 12.03 11.12 30 543681 2102 110043486
Pneumonia klebsiella 12.02 11.12 9 543702 6623 110038965
Bone callus excessive 12.02 11.12 5 543706 30 110045558
Iodine allergy 12.01 11.12 16 543695 685 110044903
Osteosclerosis 12.00 11.12 49 543662 4466 110041122
Fixed eruption 12.00 11.12 3 543708 4229 110041359
Microangiopathy 11.99 11.12 37 543674 2935 110042653
Body height decreased 11.98 11.12 91 543620 10472 110035116
Streptococcal bacteraemia 11.97 11.12 4 543707 4665 110040923
Bowel movement irregularity 11.94 11.12 12 543699 7648 110037940
Pigmentation disorder 11.92 11.12 11 543700 7300 110038288
Tendon disorder 11.92 11.12 76 543635 8261 110037327
Nasal polyps 11.91 11.12 108 543603 13092 110032496
Type V hyperlipidaemia 11.90 11.12 24 543687 1458 110044130
Facial paralysis 11.88 11.12 70 543641 24144 110021444
Tumour marker increased 11.86 11.12 5 543706 5055 110040533
Foreign body 11.82 11.12 37 543674 2958 110042630
Calciphylaxis 11.81 11.12 3 543708 4184 110041404
Carotid artery stenosis 11.77 11.12 82 543629 9181 110036407
Actinic elastosis 11.74 11.12 6 543705 61 110045527
Injection site reaction 11.72 11.12 543 543168 88527 109957061
Benign neoplasm 11.71 11.12 21 543690 1167 110044421
Meningitis 11.70 11.12 25 543686 11677 110033911
Osteolysis 11.69 11.12 56 543655 5467 110040121
Obsessive-compulsive disorder 11.68 11.12 11 543700 7230 110038358
Heart rate abnormal 11.67 11.12 11 543700 7227 110038361
Purulent discharge 11.67 11.12 67 543644 7016 110038572
Lymphocytosis 11.67 11.12 6 543705 5405 110040183
Adenocarcinoma of colon 11.67 11.12 8 543703 6160 110039428
Pre-existing condition improved 11.65 11.12 9 543702 6517 110039071
Hand fracture 11.58 11.12 74 543637 8048 110037540
Cutis laxa 11.57 11.12 8 543703 147 110045441
Papule 11.57 11.12 20 543691 10113 110035475
Cataract nuclear 11.56 11.12 23 543688 1383 110044205
Antinuclear antibody positive 11.55 11.12 81 543630 9087 110036501
Hypovolaemia 11.53 11.12 61 543650 21613 110023975
Neuromyelitis optica spectrum disorder 11.53 11.12 24 543687 1491 110044097
Angiopathy 11.52 11.12 78 543633 8652 110036936
Atypical pneumonia 11.49 11.12 13 543698 7849 110037739
Avulsion fracture 11.48 11.12 11 543700 326 110045262
Hyperuricaemia 11.47 11.12 35 543676 14496 110031092
Endophthalmitis 11.47 11.12 14 543697 8173 110037415
Haematocrit increased 11.46 11.12 5 543706 4954 110040634
Anaphylactoid reaction 11.45 11.12 10 543701 6816 110038772
Logorrhoea 11.45 11.12 5 543706 4952 110040636
Periostitis 11.45 11.12 17 543694 806 110044782
Venous thrombosis 11.44 11.12 15 543696 8490 110037098
Eye infection 11.44 11.12 35 543676 14483 110031105
Epicondylitis 11.40 11.12 33 543678 2527 110043061
Bursa disorder 11.39 11.12 10 543701 264 110045324
Apnoea 11.38 11.12 32 543679 13607 110031981
Acute febrile neutrophilic dermatosis 11.37 11.12 5 543706 4931 110040657
Listless 11.34 11.12 4 543707 4511 110041077
Nasal dryness 11.34 11.12 7 543704 5699 110039889
Dysplastic naevus syndrome 11.33 11.12 4 543707 14 110045574
Malnutrition 11.29 11.12 83 543628 27196 110018392
Mean cell haemoglobin concentration decreased 11.25 11.12 7 543704 5675 110039913
Amino acid level increased 11.25 11.12 17 543694 819 110044769
Injection site vesicles 11.17 11.12 4 543707 4467 110041121
Fibroma 11.16 11.12 19 543692 1013 110044575
Bladder prolapse 11.16 11.12 23 543688 1419 110044169
Post laminectomy syndrome 11.14 11.12 12 543699 410 110045178
Product administration error 11.13 11.12 123 543588 37094 110008494
Hypertonia 11.13 11.12 15 543696 8391 110037197
Oesophagitis haemorrhagic 11.12 11.12 15 543696 650 110044938

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M05BA04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates
ATC M05BB03 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB05 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB06 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
FDA CS M0006519 Diphosphonates
FDA EPC N0000175579 Bisphosphonate
CHEBI has role CHEBI:50643 EC 2.5.1.1 (dimethylallyl<i>trans</i>transferase) inhibitor
CHEBI has role CHEBI:50646 bone density conservation agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:64951 anti-HBV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
MeSH PA D050071 Bone Density Conservation Agents

Related Drugs by ATC class:

M05BA Bisphosphonates 7 drugs
clodronic acidetidronic acidibandronic acidpamidronic acidrisedronic acidtiludronic acidzoledronic acid
M05BB Bisphosphonates, combinations 6 drugs
alfacalcidolcolecalciferoletidronic acidibandronic acidrisedronic acidzoledronic acid

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteitis deformans indication 2089002 DOID:5408
Postmenopausal osteoporosis indication 102447009
Hypogonadal Osteoporosis in Males indication
Prevention of Glucocorticoid-Induced Osteoporosis indication
Glucocorticoid Induced Osteoporosis indication
Complex regional pain syndrome off-label use 128200000 DOID:3223
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Esophagitis contraindication 16761005 DOID:11963
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Ulcer of esophagus contraindication 30811009
Sarcoidosis contraindication 31541009 DOID:11335
Vitamin D deficiency contraindication 34713006
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Atrial fibrillation contraindication 49436004 DOID:0060224
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Stricture of esophagus contraindication 63305008
Hypercalcemia contraindication 66931009 DOID:12678
Fracture of femur contraindication 71620000
Duodenitis contraindication 72007001 DOID:8643
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Bed-ridden contraindication 160685001
Acute peptic ulcer contraindication 196682000
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Aseptic necrosis of bone of jaw contraindication 441809006
High Grade Dysplasia associated with Barrett's Esophagus contraindication
Esophageal Obstruction contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.27 acidic
pKa2 5.34 acidic
pKa3 6.32 acidic
pKa4 10.39 acidic
pKa5 12.82 acidic
pKa6 10.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Farnesyl pyrophosphate synthase Enzyme INHIBITOR Ki 7.35 CHEMBL CHEMBL
Protein farnesyltransferase subunit beta Enzyme IC50 7.30 WOMBAT-PK
Farnesyl pyrophosphate synthase Enzyme Ki 7.02 CHEMBL
Farnesyl pyrophosphate synthase Enzyme IC50 5.77 CHEMBL
Isopentenyl-diphosphate Delta-isomerase 1 Enzyme IC50 5.77 CHEMBL
Farnesyl pyrophosphate synthase Enzyme IC50 4.82 CHEMBL
Farnesyl pyrophosphate synthase, EC 2.5.1.1, EC 2.5.1.10 Enzyme Ki 7.04 CHEMBL

External reference:

IDSource
4020932 VUID
N0000148414 NUI
D00939 KEGG_DRUG
121268-17-5 SECONDARY_CAS_RN
203152 RXNORM
C0771311 UMLSCUI
CHEBI:2567 CHEBI
212 PDB_CHEM_ID
CHEMBL870 ChEMBL_ID
CHEMBL675 ChEMBL_ID
DB00630 DRUGBANK_ID
2088 PUBCHEM_CID
6462 INN_ID
X1J18R4W8P UNII
131536 MMSL
4146 MMSL
d03849 MMSL
D019386 MESH_DESCRIPTOR_UI
3141 IUPHAR_LIGAND_ID
4020932 VANDF
005056 NDDF
005057 NDDF
1217581008 SNOMEDCT_US
391729003 SNOMEDCT_US
391730008 SNOMEDCT_US
421552005 SNOMEDCT_US
96290008 SNOMEDCT_US
X1J18R4W8P INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-0282 SOLUTION 70 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1676 TABLET 5 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1678 TABLET 10 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1679 TABLET 35 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1680 TABLET 40 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1681 TABLET 70 mg ORAL ANDA 29 sections
Binosto HUMAN PRESCRIPTION DRUG LABEL 1 0178-0101 TABLET, EFFERVESCENT 70 mg ORAL NDA 20 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-696 TABLET 35 mg ORAL ANDA 27 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-697 TABLET 70 mg ORAL ANDA 27 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-718 TABLET 35 mg ORAL ANDA 29 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-719 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-631 TABLET 10 mg ORAL ANDA 28 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-632 TABLET 35 mg ORAL ANDA 28 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-633 TABLET 70 mg ORAL ANDA 28 sections
Binosto HUMAN PRESCRIPTION DRUG LABEL 1 17139-400 TABLET, EFFERVESCENT 70 mg ORAL NDA 20 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-901 TABLET 35 mg ORAL ANDA 27 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-902 TABLET 70 mg ORAL ANDA 27 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-554 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-820 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-993 TABLET 35 mg ORAL ANDA 29 sections
alendronate sodium HUMAN PRESCRIPTION DRUG LABEL 1 50090-1091 TABLET 35 mg ORAL ANDA 27 sections
alendronate sodium HUMAN PRESCRIPTION DRUG LABEL 1 50090-1095 TABLET 70 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 50090-1802 TABLET 70 mg ORAL ANDA 28 sections
Alendronate Sodium Human Prescription Drug Label 1 50090-1803 TABLET 35 mg ORAL ANDA 28 sections
Alendronate Sodium Human Prescription Drug Label 1 50090-3126 TABLET 70 mg ORAL ANDA 28 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 50090-3593 TABLET 35 mg ORAL ANDA 29 sections
ALENDRONATE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 50090-4076 TABLET 35 mg ORAL ANDA 24 sections
ALENDRONATE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 50090-4692 TABLET 70 mg ORAL ANDA 24 sections
Alendronate Sodium Human Prescription Drug Label 1 50090-5474 TABLET 35 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 50090-5677 TABLET 70 mg ORAL ANDA 27 sections