alendronic acid ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium metabolism regulator, pharmaceutical aid 112 66376-36-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alendronate monosodium salt trihydrate
  • alendronate sodium trihydrate
  • alendronate sodium hydrate
  • alendronate
  • alendronic acid
  • alendronate sodium
  • aminohydroxybutane bisphosphonate
  • MK-217
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
  • Molecular weight: 249.10
  • Formula: C4H13NO7P2
  • CLOGP: -3.79
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 6
  • TPSA: 161.31
  • ALOGS: -1.17
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg O
10 mg O
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 45 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.68 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.33 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.22 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 29, 1995 FDA MERCK AND CO INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Femur fracture 6779.38 10.70 3911 412316 37845 63034950
Low turnover osteopathy 3111.52 10.70 1133 415094 3052 63069743
Osteonecrosis 2689.81 10.70 1791 414436 22739 63050056
Pemphigus 2497.72 10.70 4385 411842 179341 62893454
Osteonecrosis of jaw 2366.65 10.70 1911 414316 33212 63039583
Systemic lupus erythematosus 2212.84 10.70 4482 411745 204436 62868359
Intramedullary rod insertion 2191.08 10.70 734 415493 1389 63071406
Glossodynia 2111.33 10.70 4017 412210 174859 62897936
Hand deformity 1586.77 10.70 3336 412891 156121 62916674
Stress fracture 1502.34 10.70 824 415403 7139 63065656
Arthropathy 1456.00 10.70 4092 412135 230700 62842095
Abdominal discomfort 1396.60 10.70 4947 411280 315938 62756857
Atypical femur fracture 1392.62 10.70 688 415539 4684 63068111
Wound 1377.08 10.70 3197 413030 160066 62912729
Alopecia 1245.04 10.70 4935 411292 332601 62740194
Fracture nonunion 1180.10 10.70 475 415752 1820 63070975
Osteoarthritis 1115.39 10.70 2135 414092 93208 62979587
Pericarditis 1066.91 10.70 2538 413689 129041 62943754
Toxicity to various agents 1023.96 10.70 191 416036 247059 62825736
Open reduction of fracture 1008.86 10.70 353 415874 809 63071986
Anti-cyclic citrullinated peptide antibody positive 1004.85 10.70 2299 413928 113913 62958882
Dental caries 953.45 10.70 690 415537 10089 63062706
Impaired healing 934.93 10.70 2072 414155 100470 62972325
Discomfort 932.25 10.70 2809 413418 164565 62908230
Osteomyelitis 927.57 10.70 993 415234 25027 63047768
Anaemia postoperative 916.59 10.70 394 415833 1848 63070947
Death 886.24 10.70 695 415532 373686 62699109
Swelling 873.80 10.70 3847 412380 271531 62801264
Contraindicated product administered 853.70 10.70 3247 412980 214401 62858394
Hyperlipidaemia 841.05 10.70 826 415401 18745 63054050
Nausea 805.38 10.70 2894 413333 851577 62221218
Completed suicide 761.48 10.70 49 416178 145624 62927171
Tooth disorder 742.96 10.70 920 415307 27237 63045558
Duodenal ulcer perforation 737.83 10.70 1711 414516 85498 62987297
Synovitis 726.45 10.70 2781 413446 184137 62888658
Diarrhoea 702.66 10.70 2379 413848 712987 62359808
Helicobacter infection 694.35 10.70 1736 414491 91049 62981746
Jaw disorder 655.62 10.70 419 415808 4930 63067865
Spinal osteoarthritis 645.48 10.70 656 415571 15530 63057265
Product dose omission issue 626.94 10.70 380 415847 233933 62838862
Oral infection 598.62 10.70 385 415842 4583 63068212
Vomiting 585.56 10.70 1808 414419 557809 62514986
Neutropenia 581.78 10.70 210 416017 174795 62898000
Infusion related reaction 563.31 10.70 3129 413098 242392 62830403
Blood cholesterol increased 547.47 10.70 1604 414623 92428 62980367
Rheumatoid factor positive 545.27 10.70 1495 414732 82911 62989884
Acute kidney injury 525.60 10.70 571 415656 262844 62809951
Vitamin D deficiency 524.97 10.70 547 415680 13345 63059450
Bone disorder 516.90 10.70 668 415559 20658 63052137
Hypercholesterolaemia 513.57 10.70 666 415561 20668 63052127
Osteopenia 505.20 10.70 636 415591 19149 63053646
Off label use 501.17 10.70 2499 413728 671963 62400832
Febrile neutropenia 493.15 10.70 90 416137 118359 62954436
Drug interaction 487.34 10.70 470 415757 228661 62844134
Hepatic enzyme increased 485.01 10.70 2610 413617 199718 62873077
Foot fracture 483.68 10.70 686 415541 23228 63049567
Intervertebral disc degeneration 479.03 10.70 553 415674 15179 63057616
Fracture delayed union 471.68 10.70 256 415971 2166 63070629
Maternal exposure during pregnancy 467.45 10.70 2748 413479 217314 62855481
Tooth fracture 457.12 10.70 458 415769 10652 63062143
Gastrooesophageal reflux disease 454.84 10.70 1521 414706 94118 62978677
Hypotension 440.04 10.70 692 415535 271912 62800883
Hip arthroplasty 438.62 10.70 967 415260 46679 63026116
Bursitis 438.28 10.70 834 415393 36207 63036588
Exostosis of jaw 438.15 10.70 199 416028 1090 63071705
Device failure 436.53 10.70 342 415885 5669 63067126
Disease progression 432.90 10.70 133 416094 122625 62950170
Intentional overdose 426.32 10.70 13 416214 74139 62998656
COVID-19 425.91 10.70 108 416119 112995 62959800
Temporomandibular joint syndrome 425.06 10.70 289 415938 3800 63068995
Adverse event 421.82 10.70 1182 415045 66377 63006418
Knee arthroplasty 410.34 10.70 1019 415208 53187 63019608
Product use issue 405.70 10.70 2654 413573 217866 62854929
Gingival disorder 384.12 10.70 257 415970 3285 63069510
Drug intolerance 379.79 10.70 3380 412847 305281 62767514
Medical device removal 377.60 10.70 179 416048 1098 63071697
Drug abuse 377.03 10.70 25 416202 72493 63000302
Periodontal disease 357.01 10.70 187 416040 1461 63071334
Pathological fracture 355.79 10.70 360 415867 8474 63064321
Headache 336.30 10.70 2603 413624 630638 62442157
Spondylolisthesis 334.87 10.70 236 415991 3300 63069495
Exostosis 334.38 10.70 494 415733 17368 63055427
Thrombocytopenia 334.27 10.70 299 415928 150858 62921937
Irritable bowel syndrome 331.86 10.70 1241 414986 81171 62991624
Rheumatic fever 325.81 10.70 810 415417 42301 63030494
Malignant neoplasm progression 321.78 10.70 72 416155 82049 62990746
Scoliosis 316.86 10.70 321 415906 7567 63065228
Calcium deficiency 307.66 10.70 149 416078 965 63071830
Asthenia 307.03 10.70 1382 414845 382222 62690573
Internal fixation of fracture 306.66 10.70 133 416094 640 63072155
Diverticulum 303.80 10.70 384 415843 11607 63061188
Muscle injury 303.30 10.70 1031 415196 64314 63008481
Suicide attempt 302.51 10.70 26 416201 60892 63011903
Injection site pain 301.35 10.70 245 415982 129555 62943240
Bone loss 300.85 10.70 210 416017 2889 63069906
Hypersensitivity 293.23 10.70 3070 413157 289615 62783180
Type 2 diabetes mellitus 291.44 10.70 1002 415225 62866 63009929
Tooth extraction 291.22 10.70 348 415879 9916 63062879
Bone density decreased 289.34 10.70 415 415812 14197 63058598
Folliculitis 288.21 10.70 1065 415162 69252 63003543
Rib fracture 286.29 10.70 524 415703 22073 63050722
White blood cell count decreased 285.60 10.70 294 415933 138810 62933985
Dyspnoea 285.41 10.70 2867 413360 658446 62414349
Swollen joint count increased 282.61 10.70 687 415540 35367 63037428
Malaise 280.79 10.70 1590 414637 414364 62658431
Osteoporosis 280.60 10.70 921 415306 56417 63016378
Blister 280.41 10.70 1629 414598 128185 62944610
Cardiac arrest 272.13 10.70 133 416094 92412 62980383
Lumbar spinal stenosis 266.08 10.70 234 415993 4588 63068207
Pyrexia 264.57 10.70 1902 414325 468576 62604219
Tooth loss 264.50 10.70 273 415954 6583 63066212
Spinal compression fracture 264.46 10.70 393 415834 13890 63058905
Jaw fracture 259.24 10.70 180 416047 2454 63070341
Hip fracture 258.66 10.70 587 415640 28887 63043908
Abortion spontaneous 258.52 10.70 12 416215 47183 63025612
Seizure 245.39 10.70 305 415922 132329 62940466
Platelet count decreased 244.56 10.70 240 415987 115882 62956913
Hyperhidrosis 243.56 10.70 209 416018 107627 62965168
Therapeutic product effect decreased 243.14 10.70 2127 414100 191060 62881735
Rotator cuff syndrome 240.70 10.70 365 415862 13137 63059658
Kyphosis 234.69 10.70 167 416060 2373 63070422
Sleep disorder due to general medical condition, insomnia type 233.67 10.70 814 415413 51403 63021392
Ulna fracture 233.54 10.70 126 416101 1052 63071743
Loose tooth 233.36 10.70 187 416040 3207 63069588
Sepsis 232.57 10.70 404 415823 152719 62920076
Resorption bone increased 232.48 10.70 129 416098 1145 63071650
Feeling abnormal 232.30 10.70 384 415843 148008 62924787
Blood parathyroid hormone decreased 231.49 10.70 303 415924 9488 63063307
Periodontitis 229.26 10.70 183 416044 3120 63069675
Basal cell carcinoma 227.57 10.70 541 415686 27450 63045345
Hypertension 224.84 10.70 2808 413419 276495 62796300
Large intestine polyp 222.33 10.70 271 415956 7886 63064909
Radius fracture 220.05 10.70 186 416041 3449 63069346
Somnolence 218.42 10.70 534 415693 178151 62894644
Bone graft 218.42 10.70 113 416114 858 63071937
Blood loss anaemia 216.61 10.70 281 415946 8720 63064075
Fibrocystic breast disease 212.88 10.70 119 416108 1073 63071722
Granuloma skin 210.27 10.70 268 415959 8169 63064626
Muscle strain 204.91 10.70 262 415965 8012 63064783
Tonsillar disorder 202.91 10.70 114 416113 1039 63071756
Cardio-respiratory arrest 200.70 10.70 71 416156 59888 63012907
Injection site erythema 200.58 10.70 151 416076 83023 62989772
Electrocardiogram QT prolonged 200.11 10.70 70 416157 59460 63013335
Panniculitis 199.04 10.70 305 415922 11080 63061715
Limb asymmetry 198.98 10.70 102 416125 758 63072037
Oral disorder 198.54 10.70 267 415960 8587 63064208
Oral cavity fistula 195.30 10.70 93 416134 577 63072218
Wrist fracture 195.26 10.70 333 415894 13254 63059541
Tremor 194.40 10.70 356 415871 131883 62940912
Anaphylactic reaction 194.31 10.70 95 416132 66005 63006790
Intentional product misuse 194.10 10.70 78 416149 60839 63011956
Fall 193.68 10.70 3629 412598 388705 62684090
Lumbar radiculopathy 192.48 10.70 134 416093 1835 63070960
Pancytopenia 192.07 10.70 211 416016 96722 62976073
Edentulous 191.25 10.70 70 416157 192 63072603
Cerumen impaction 189.37 10.70 107 416120 987 63071808
Tonsillectomy 188.73 10.70 99 416128 776 63072019
Tooth abscess 188.20 10.70 346 415881 14623 63058172
Pelvic fracture 187.70 10.70 324 415903 13024 63059771
Weight decreased 187.62 10.70 1056 415171 275742 62797053
Pain 187.35 10.70 6256 409971 734372 62338423
Tibia fracture 187.00 10.70 198 416029 4922 63067873
Liver injury 184.81 10.70 837 415390 59683 63013112
Joint swelling 183.37 10.70 3092 413135 324574 62748221
Foetal exposure during pregnancy 182.27 10.70 6 416221 31956 63040839
Pneumonia 182.01 10.70 2016 414211 454751 62618044
Cough 181.46 10.70 1149 415078 291594 62781201
Gingivitis 179.65 10.70 248 415979 8181 63064614
Flushing 178.91 10.70 138 416089 74949 62997846
Neutrophil count decreased 176.84 10.70 74 416153 56332 63016463
Dehydration 175.62 10.70 567 415660 172787 62900008
Drug tolerance decreased 174.94 10.70 367 415860 17106 63055689
Depressed level of consciousness 172.43 10.70 96 416131 61982 63010813
Premature delivery 171.57 10.70 6 416221 30275 63042520
Rheumatoid nodule 171.38 10.70 360 415867 16795 63056000
Hospitalisation 171 10.70 183 416044 84898 62987897
Meniscus injury 169.49 10.70 221 416006 6893 63065902
Leukopenia 169.44 10.70 154 416073 77136 62995659
Wrong technique in product usage process 169.44 10.70 99 416128 62241 63010554
Uterine disorder 169.30 10.70 151 416076 3018 63069777
Loss of consciousness 169.20 10.70 323 415904 117798 62954997
Dizziness 168.68 10.70 1904 414323 428021 62644774
Abdominal pain 168.21 10.70 1179 415048 292277 62780518
Atypical fracture 166.45 10.70 82 416145 554 63072241
Multiple organ dysfunction syndrome 161.67 10.70 85 416142 56667 63016128
Tachycardia 161.57 10.70 332 415895 117824 62954971
Fistula discharge 157.71 10.70 95 416132 998 63071797
Fibula fracture 156.82 10.70 152 416075 3390 63069405
Periprosthetic fracture 155.71 10.70 71 416156 393 63072402
Illness 154.38 10.70 64 416163 48995 63023800
Patellofemoral pain syndrome 154.17 10.70 78 416149 562 63072233
Stress urinary incontinence 153.98 10.70 126 416101 2229 63070566
Lactic acidosis 153.15 10.70 32 416195 38255 63034540
Neoplasm progression 153.02 10.70 27 416200 36401 63036394
Pulmonary embolism 151.93 10.70 337 415890 116347 62956448
Mitral valve prolapse 150.13 10.70 125 416102 2268 63070527
Sedation 150.06 10.70 35 416192 38774 63034021
Overdose 148.50 10.70 334 415893 114744 62958051
Psoriatic arthropathy 148.09 10.70 1068 415159 90452 62982343
Mucosal inflammation 148.02 10.70 61 416166 46867 63025928
Cognitive disorder 146.99 10.70 92 416135 55723 63017072
Respiratory failure 145.46 10.70 279 415948 101579 62971216
Respiratory arrest 144.31 10.70 21 416206 32624 63040171
Osteitis 144.02 10.70 140 416087 3134 63069661
Synovial cyst 143.77 10.70 251 415976 10182 63062613
Removal of internal fixation 142.96 10.70 43 416184 45 63072750
Drug reaction with eosinophilia and systemic symptoms 142.30 10.70 25 416202 33811 63038984
Skin necrosis 141.99 10.70 295 415932 13655 63059140
Appendix disorder 140.64 10.70 100 416127 1419 63071376
Fracture displacement 140.37 10.70 93 416134 1168 63071627
Exposed bone in jaw 139.91 10.70 131 416096 2794 63070001
Tendonitis 138.23 10.70 359 415868 19256 63053539
Ligament sprain 137.76 10.70 277 415950 12523 63060272
Ulcer 135.52 10.70 428 415799 25679 63047116
Dental fistula 134.03 10.70 71 416156 569 63072226
Abscess jaw 133.75 10.70 94 416133 1308 63071487
Haemorrhoids 133.73 10.70 383 415844 21767 63051028
Drug ineffective for unapproved indication 133.14 10.70 30 416197 34033 63038762
Suicidal ideation 132.55 10.70 128 416099 62293 63010502
Psoriasis 132.36 10.70 229 415998 86728 62986067
Adverse drug reaction 131.73 10.70 935 415292 78779 62994016
Injection site swelling 131.49 10.70 74 416153 47498 63025297
Dental necrosis 131.28 10.70 46 416181 106 63072689
Treatment failure 131.15 10.70 1931 414296 197112 62875683
Hiatus hernia 130.97 10.70 374 415853 21220 63051575
Intentional self-injury 130.19 10.70 10 416217 25677 63047118
Therapy interrupted 130.08 10.70 27 416200 32428 63040367
Unevaluable event 129.49 10.70 89 416138 51297 63021498
Cataract operation 129.16 10.70 170 416057 5352 63067443
Blood glucose increased 128.92 10.70 219 416008 83537 62989258
Agitation 128.69 10.70 121 416106 59636 63013159
Blood pressure increased 128.65 10.70 585 415642 161477 62911318
Feeling hot 128.51 10.70 86 416141 50268 63022527
Appendicectomy 128.02 10.70 125 416102 2814 63069981
Cystocele 127.95 10.70 86 416141 1108 63071687
Anaemia 126.45 10.70 1271 414956 292159 62780636
Multiple sclerosis relapse 126.16 10.70 81 416146 48397 63024398
Cataract 125.71 10.70 720 415507 56333 63016462
Hypercalcaemia 125.37 10.70 440 415787 27882 63044913
Atrophic vulvovaginitis 124.95 10.70 99 416128 1669 63071126
Metabolic acidosis 124.72 10.70 70 416157 44999 63027796
Renal failure 124.63 10.70 377 415850 117275 62955520
Varicose vein 121.85 10.70 157 416070 4838 63067957
Renal impairment 121.85 10.70 247 415980 88108 62984687
Breast disorder 120.42 10.70 113 416114 2417 63070378
Therapeutic product effect incomplete 119.12 10.70 420 415807 124636 62948159
Drug resistance 118.90 10.70 8 416219 22925 63049870
Chest discomfort 116.75 10.70 352 415875 109617 62963178
Dental implantation 116.22 10.70 68 416159 674 63072121
Encephalopathy 115.80 10.70 54 416173 38566 63034229
Hyperaesthesia teeth 114.13 10.70 95 416132 1723 63071072
Accidental exposure to product 113.62 10.70 21 416206 27384 63045411
Femoral neck fracture 113.50 10.70 202 416025 8321 63064474
Septic shock 113.23 10.70 163 416064 66466 63006329
Oestrogen deficiency 113.02 10.70 42 416185 122 63072673
Hypothyroidism 112.97 10.70 566 415661 42066 63030729
Contusion 111.86 10.70 1488 414739 148556 62924239
Blood creatinine increased 111.66 10.70 257 415970 87587 62985208
Sopor 111.29 10.70 9 416218 22155 63050640
Joint effusion 110.87 10.70 303 415924 16757 63056038
Vertebral foraminal stenosis 110.17 10.70 73 416154 917 63071878
Periodontal operation 109.62 10.70 30 416197 14 63072781
Fractured sacrum 109.57 10.70 97 416130 1919 63070876
Foot deformity 109.19 10.70 416 415811 27437 63045358
Disturbance in attention 109.06 10.70 57 416170 38132 63034663
Alveolar osteitis 108.98 10.70 70 416157 831 63071964
Myelosuppression 107.72 10.70 14 416213 23689 63049106
Arthritis 106.54 10.70 1196 415031 114725 62958070
Arthralgia 106.04 10.70 4655 411572 565055 62507740
Chills 105.84 10.70 384 415843 112994 62959801
Gastrointestinal disorder 105.18 10.70 1319 414908 129920 62942875
Jaw operation 105.05 10.70 67 416160 785 63072010
Bradycardia 105.04 10.70 200 416027 73027 62999768
Intervertebral disc protrusion 104.65 10.70 368 415859 23341 63049454
Cardiac murmur 104.25 10.70 268 415959 14284 63058511
Oxygen saturation decreased 104.08 10.70 270 415957 88315 62984480
Bone lesion 103.43 10.70 158 416069 5723 63067072
Skin discolouration 102.90 10.70 60 416167 37768 63035027
Seborrhoeic keratosis 102.74 10.70 100 416127 2242 63070553
Rash erythematous 102.70 10.70 77 416150 42433 63030362
Haemoglobin decreased 101.20 10.70 550 415677 144935 62927860
Inappropriate schedule of product administration 99.79 10.70 348 415879 103617 62969178
Hysterectomy 99.17 10.70 203 416024 9296 63063499
Abscess 98.48 10.70 286 415941 16382 63056413
Humerus fracture 98.41 10.70 195 416032 8721 63064074
Compression fracture 97.93 10.70 162 416065 6286 63066509
Hepatic failure 97.78 10.70 56 416171 35600 63037195
Lower limb fracture 97.64 10.70 365 415862 23856 63048939
Pulpitis dental 97.43 10.70 66 416161 862 63071933
Depressed mood 96.83 10.70 73 416154 40118 63032677
Angioedema 96.55 10.70 103 416124 47862 63024933
Injection site pruritus 96.39 10.70 92 416135 45024 63027771
Influenza like illness 96.30 10.70 182 416045 66642 63006153
Dry skin 95.84 10.70 140 416087 56747 63016048
Oesophagitis 94.99 10.70 264 415963 14744 63058051
Fibromyalgia 94.63 10.70 873 415354 79547 62993248
Caesarean section 94.36 10.70 4 416223 17028 63055767
Injection site bruising 93.65 10.70 82 416145 41828 63030967
Carotid bruit 93.33 10.70 59 416168 680 63072115
Extraskeletal ossification 93.22 10.70 34 416193 92 63072703
Pruritus 92.41 10.70 1741 414486 359712 62713083
Patella fracture 92.25 10.70 91 416136 2075 63070720
Hepatotoxicity 92.21 10.70 65 416162 36976 63035819
Injection site reaction 91.93 10.70 151 416076 58373 63014422
Neuropathy peripheral 91.56 10.70 408 415819 113259 62959536
Abscess oral 91.22 10.70 79 416148 1516 63071279
Erythema 91.10 10.70 726 415501 175025 62897770
Vascular calcification 90.90 10.70 59 416168 714 63072081
Pulmonary oedema 90.54 10.70 137 416090 54736 63018059
Fracture 89.94 10.70 308 415919 19276 63053519
Spinal fracture 89.80 10.70 294 415933 17977 63054818
Serotonin syndrome 89.30 10.70 38 416189 28644 63044151
Road traffic accident 89.19 10.70 475 415752 36157 63036638
Oral surgery 89.15 10.70 70 416157 1164 63071631
Fistula 88.97 10.70 205 416022 10188 63062607
Toxic epidermal necrolysis 88.26 10.70 28 416199 25306 63047489
Ascites 88.24 10.70 82 416145 40646 63032149
Drug ineffective 87.03 10.70 5795 410432 1038970 62033825
Essential hypertension 86.80 10.70 134 416093 4899 63067896
Epistaxis 86.70 10.70 220 416007 72505 63000290
Drug withdrawal syndrome 86.33 10.70 35 416192 27159 63045636
Sciatica 86.26 10.70 449 415778 33875 63038920
Osteomyelitis chronic 86.16 10.70 47 416180 402 63072393
Fracture malunion 85.97 10.70 35 416192 139 63072656
Hepatocellular injury 85.69 10.70 36 416191 27345 63045450
Vision blurred 85.35 10.70 312 415915 91612 62981183
Nasal congestion 85.14 10.70 190 416037 65470 63007325
Hand fracture 83.88 10.70 140 416087 5473 63067322
Paraesthesia 83.86 10.70 643 415584 156323 62916472
Influenza 83.56 10.70 397 415830 108325 62964470
Generalised tonic-clonic seizure 83.31 10.70 43 416184 28973 63043822
Endodontic procedure 83.30 10.70 104 416123 3103 63069692
No adverse event 83.24 10.70 89 416138 41316 63031479
Fluid retention 83.02 10.70 166 416061 59520 63013275
Urticaria 82.68 10.70 692 415535 165110 62907685
Gingival recession 82.56 10.70 72 416155 1395 63071400
Anaphylactic shock 82.55 10.70 26 416201 23607 63049188
Clostridium difficile infection 82.04 10.70 47 416180 29875 63042920
Oroantral fistula 81.44 10.70 35 416192 164 63072631
Creatinine renal clearance decreased 80.84 10.70 7 416220 16301 63056494
Rectocele 80.59 10.70 62 416165 999 63071796
Oropharyngeal pain 80.48 10.70 332 415895 94155 62978640
Therapy cessation 80.47 10.70 50 416177 30407 63042388
Rhinorrhoea 80.03 10.70 196 416031 65381 63007414
Polymyalgia rheumatica 79.98 10.70 111 416116 3680 63069115
Dental plaque 79.78 10.70 30 416197 91 63072704
Restlessness 79.71 10.70 47 416180 29406 63043389
Cholestasis 79.61 10.70 47 416180 29387 63043408
Posterior reversible encephalopathy syndrome 79.41 10.70 10 416217 17335 63055460
Iliotibial band syndrome 79.31 10.70 35 416192 177 63072618
Constipation 79.30 10.70 1019 415208 223924 62848871
Spinal laminectomy 78.91 10.70 53 416174 682 63072113
Skin exfoliation 78.74 10.70 100 416127 43002 63029793
Osteoradionecrosis 78.60 10.70 30 416197 96 63072699
Transaminases increased 78.13 10.70 55 416172 31312 63041483
Ankle fracture 77.83 10.70 276 415951 17579 63055216
Peptic ulcer 77.54 10.70 121 416106 4466 63068329
Bone marrow failure 77.50 10.70 48 416179 29242 63043553
Pallor 76.94 10.70 53 416174 30515 63042280
Lumbosacral radiculopathy 76.89 10.70 43 416184 388 63072407
Blood pressure decreased 76.51 10.70 198 416029 64824 63007971
Arthroscopy 76.41 10.70 51 416176 649 63072146
Joint dislocation 76.35 10.70 284 415943 18516 63054279
Dyslipidaemia 76.01 10.70 157 416070 7236 63065559
Irritability 75.80 10.70 58 416169 31636 63041159
Colitis 75.48 10.70 126 416101 48402 63024393
Gingival bleeding 75.35 10.70 217 416010 12370 63060425
Ill-defined disorder 75.32 10.70 844 415383 80911 62991884
Osteopetrosis 75.10 10.70 23 416204 27 63072768
Device issue 74.85 10.70 31 416196 23750 63049045
Haemorrhage 74.77 10.70 182 416045 60840 63011955
Decreased appetite 74.49 10.70 1177 415050 249875 62822920
Diabetic ketoacidosis 74.46 10.70 21 416206 20484 63052311
Neutropenic sepsis 74.00 10.70 10 416217 16428 63056367
COVID-19 pneumonia 73.54 10.70 5 416222 14204 63058591
Hyperkalaemia 73.47 10.70 153 416074 54050 63018745
Acute sinusitis 73.46 10.70 108 416119 3779 63069016
Blood bilirubin increased 73.37 10.70 81 416146 37059 63035736
Pericardial effusion 73.18 10.70 54 416173 30004 63042791
Biopsy bone 72.81 10.70 24 416203 42 63072753
Urinary tract infection 72.59 10.70 1259 414968 263425 62809370
Pleural effusion 72.42 10.70 339 415888 92871 62979924
Dyskinesia 72.25 10.70 62 416165 31940 63040855
Bone metabolism disorder 71.80 10.70 40 416187 358 63072437
Incorrect dose administered 71.80 10.70 181 416046 59787 63013008
Lower respiratory tract infection 71.42 10.70 1242 414985 131065 62941730
Closed fracture manipulation 71.36 10.70 20 416207 12 63072783
Tooth deposit 70.74 10.70 34 416193 216 63072579
Neurotoxicity 70.47 10.70 13 416214 16977 63055818
Abdominal distension 70.29 10.70 310 415917 86305 62986490
Peripheral vascular disorder 70.27 10.70 135 416092 5900 63066895
Product use in unapproved indication 70.05 10.70 793 415434 178287 62894508
Abdominal pain upper 69.90 10.70 943 415284 205501 62867294
Infusion site pain 69.77 10.70 13 416214 16856 63055939
Spinal stenosis 69.65 10.70 236 415991 14689 63058106
Disorientation 69.53 10.70 94 416133 39358 63033437
Skin ulcer 69.40 10.70 502 415725 42543 63030252
Drug level increased 69.39 10.70 31 416196 22705 63050090
Palmar-plantar erythrodysaesthesia syndrome 69.28 10.70 32 416195 22983 63049812
Peripheral venous disease 68.97 10.70 241 415986 15236 63057559
Aortic arteriosclerosis 68.77 10.70 136 416091 6073 63066722
Psychotic disorder 68.22 10.70 42 416185 25670 63047125
Nasal septum deviation 68.16 10.70 66 416161 1470 63071325
Acquired oesophageal web 67.85 10.70 33 416194 216 63072579
Acetabulum fracture 67.70 10.70 36 416191 291 63072504
Dysgeusia 67.49 10.70 127 416100 46583 63026212
Abnormal behaviour 67.32 10.70 28 416199 21398 63051397
Oedema mouth 67.12 10.70 81 416146 2332 63070463
Status epilepticus 66.86 10.70 10 416217 15223 63057572
Breast calcifications 66.50 10.70 60 416167 1218 63071577
Cytomegalovirus infection 66.45 10.70 27 416200 20925 63051870
Lacrimation increased 66.39 10.70 26 416201 20605 63052190
Cytokine release syndrome 66.15 10.70 8 416219 14306 63058489
Acute hepatic failure 66.12 10.70 19 416208 18308 63054487
Stomatitis 66.06 10.70 1277 414950 137448 62935347
Pancreatitis 66.04 10.70 139 416088 48916 63023879
Palpitations 66.00 10.70 450 415777 112320 62960475
Jaw cyst 65.79 10.70 27 416200 110 63072685
Aggression 65.73 10.70 36 416191 23462 63049333
Skeletal injury 65.67 10.70 59 416168 1191 63071604
Musculoskeletal stiffness 65.47 10.70 1629 414598 182989 62889806
Unresponsive to stimuli 65.43 10.70 75 416152 33741 63039054
Cardiac failure 65.32 10.70 331 415896 88811 62983984
Burning sensation 65.31 10.70 164 416063 54243 63018552
Pneumonitis 65.08 10.70 81 416146 35141 63037654
Withdrawal syndrome 64.69 10.70 25 416202 19972 63052823
Radiculopathy 64.19 10.70 161 416066 8450 63064345
Actinomycosis 64.12 10.70 54 416173 996 63071799
Pain in jaw 63.77 10.70 496 415731 43000 63029795
Rhabdomyolysis 63.06 10.70 120 416107 43831 63028964
Heart rate increased 62.93 10.70 361 415866 93877 62978918
Breast conserving surgery 62.11 10.70 53 416174 996 63071799
Bone formation decreased 62.09 10.70 23 416204 66 63072729
Facet joint syndrome 62.08 10.70 198 416029 11940 63060855
Hypervolaemia 61.80 10.70 57 416170 28356 63044439
Hypoglycaemia 61.78 10.70 195 416032 59870 63012925
Full blood count decreased 61.76 10.70 48 416179 25976 63046819
Eustachian tube dysfunction 61.56 10.70 37 416190 387 63072408
Haematochezia 61.51 10.70 165 416062 53379 63019416
Spinal disorder 61.50 10.70 173 416054 9729 63063066
Tenosynovitis stenosans 61.46 10.70 92 416135 3272 63069523
Heart rate decreased 61.42 10.70 129 416098 45431 63027364
Hepatic cytolysis 61.36 10.70 13 416214 15394 63057401
Heavy menstrual bleeding 61.28 10.70 20 416207 17753 63055042
Injection site mass 60.89 10.70 23 416204 18633 63054162
Trismus 60.88 10.70 99 416128 3786 63069009
Lymphocyte count decreased 60.86 10.70 65 416162 30192 63042603
Aphasia 60.86 10.70 76 416151 32924 63039871
Osteoma 60.85 10.70 19 416208 25 63072770
Pulmonary fibrosis 60.62 10.70 458 415769 39351 63033444
Altered state of consciousness 60.55 10.70 46 416181 25184 63047611
Type V hyperlipidaemia 60.53 10.70 40 416187 500 63072295
Vaginal haemorrhage 59.95 10.70 55 416172 27432 63045363
Adenotonsillectomy 59.63 10.70 20 416207 38 63072757
Carotid artery stenosis 59.40 10.70 115 416112 5055 63067740
Crying 59.38 10.70 40 416187 23303 63049492
Red blood cell count decreased 59.17 10.70 110 416117 40535 63032260
Bone fragmentation 58.65 10.70 45 416182 722 63072073
Shock 58.63 10.70 41 416186 23422 63049373
Anaemia of chronic disease 58.62 10.70 71 416156 2052 63070743
Memory impairment 58.57 10.70 421 415806 103837 62968958
Carpal tunnel syndrome 58.44 10.70 281 415946 20536 63052259
Gastritis 58.40 10.70 432 415795 36871 63035924
Renal cyst 58.22 10.70 174 416053 10128 63062667
Poisoning 57.87 10.70 10 416217 13690 63059105
Product quality issue 57.77 10.70 91 416136 35774 63037021
Arteriosclerosis coronary artery 57.72 10.70 152 416075 8221 63064574
Agranulocytosis 57.59 10.70 48 416179 25086 63047709
Bone sequestrum 57.41 10.70 59 416168 1415 63071380
Throat irritation 57.40 10.70 99 416128 37548 63035247
Red blood cell sedimentation rate abnormal 57.26 10.70 29 416198 19753 63053042
Intervertebral disc disorder 57.20 10.70 109 416118 4734 63068061
Angiopathy 57.19 10.70 106 416121 4507 63068288
Mood swings 57.09 10.70 24 416203 18224 63054571
Orthostatic hypotension 57.06 10.70 93 416134 36067 63036728
Mydriasis 56.97 10.70 6 416221 11950 63060845
Biopsy breast 56.94 10.70 31 416196 264 63072531
Bruxism 56.84 10.70 91 416136 3434 63069361
Respiratory distress 56.75 10.70 84 416143 33867 63038928
Kyphoscoliosis 56.50 10.70 37 416190 455 63072340
Lethargy 56.09 10.70 184 416043 55823 63016972
Hepatitis 55.89 10.70 110 416117 39678 63033117
Urinary tract discomfort 55.53 10.70 41 416186 619 63072176
Thrombosis 55.47 10.70 227 416000 64528 63008267
Drug eruption 55.46 10.70 350 415877 28344 63044451
Device dislocation 55.39 10.70 52 416175 25653 63047142
Debridement 55.30 10.70 53 416174 1165 63071630
Frequent bowel movements 55.22 10.70 42 416185 22980 63049815
Injury 55.19 10.70 728 415499 72519 63000276
Plasma cell myeloma 55.13 10.70 94 416133 35811 63036984
Postmenopause 54.76 10.70 19 416208 42 63072753
Eye pruritus 54.61 10.70 27 416200 18644 63054151
Red blood cell sedimentation rate 54.58 10.70 107 416120 4747 63068048
Muscle spasticity 54.57 10.70 38 416189 21756 63051039
Myoclonus 54.46 10.70 18 416209 15850 63056945
Disease recurrence 54.42 10.70 62 416165 27968 63044827
Dystonia 54.35 10.70 12 416215 13807 63058988
Rash macular 54.30 10.70 44 416183 23320 63049475
Rash maculo-papular 54.21 10.70 78 416149 31818 63040977
Gamma-glutamyltransferase increased 54.20 10.70 87 416140 33944 63038851
Osteonecrosis of external auditory canal 54.16 10.70 23 416204 104 63072691
Impaired quality of life 54.14 10.70 12 416215 13771 63059024
Urge incontinence 54.02 10.70 46 416181 862 63071933
Thoracic vertebral fracture 53.81 10.70 103 416124 4489 63068306
Scapula fracture 53.68 10.70 35 416192 427 63072368
Sequestrectomy 53.60 10.70 44 416183 782 63072013
Rhinitis allergic 53.47 10.70 184 416043 11543 63061252
Oesophageal ulcer 52.97 10.70 101 416126 4389 63068406
Hypertonic bladder 52.96 10.70 89 416138 3499 63069296
Hyperparathyroidism 52.85 10.70 77 416150 2672 63070123
Scleritis 52.72 10.70 100 416127 4328 63068467
Adjustment disorder with depressed mood 52.69 10.70 167 416060 10037 63062758
Acute respiratory distress syndrome 52.63 10.70 46 416181 23488 63049307
Dysarthria 52.63 10.70 127 416100 42584 63030211
Pernicious anaemia 52.54 10.70 40 416187 634 63072161
Tenosynovitis 52.40 10.70 204 416023 13591 63059204
Spinal meningeal cyst 52.12 10.70 18 416209 39 63072756
Carotid artery disease 51.94 10.70 59 416168 1590 63071205
Mycotic allergy 51.74 10.70 47 416180 963 63071832
Bunion operation 51.64 10.70 53 416174 1269 63071526
Actinic keratosis 51.61 10.70 74 416153 2530 63070265
Hypoxia 51.59 10.70 209 416018 59583 63013212
Reversible airways obstruction 51.51 10.70 62 416165 1780 63071015
Atrophy 51.24 10.70 60 416167 1672 63071123
Osteomalacia 51.12 10.70 41 416186 704 63072091
Stevens-Johnson syndrome 50.86 10.70 53 416174 24897 63047898
Urinary bladder suspension 50.72 10.70 35 416192 472 63072323
Brain oedema 50.69 10.70 15 416212 14180 63058615
Onychomycosis 50.66 10.70 140 416087 7792 63065003
Diverticulum intestinal 50.55 10.70 126 416101 6587 63066208
Injection site urticaria 50.02 10.70 15 416212 14058 63058737
Intraocular lens implant 49.98 10.70 30 416197 313 63072482
Malocclusion 49.81 10.70 20 416207 76 63072719
Hypophagia 49.70 10.70 80 416147 31179 63041616
Hallucination 49.60 10.70 188 416039 54629 63018166
Coronary artery disease 49.58 10.70 373 415854 32004 63040791
Therapeutic response shortened 49.51 10.70 9 416218 11879 63060916
Body height decreased 49.38 10.70 162 416065 9916 63062879
Nocturia 49.36 10.70 141 416086 8000 63064795
Therapeutic response unexpected 49.27 10.70 31 416196 18728 63054067
Blood glucose decreased 49.27 10.70 39 416188 20913 63051882
Prescribed overdose 49.26 10.70 388 415839 33765 63039030
Injection site warmth 49.14 10.70 19 416208 15176 63057619
Hypothermia 49.14 10.70 14 416213 13567 63059228
Device difficult to use 48.56 10.70 12 416215 12784 63060011
Vital capacity decreased 48.05 10.70 58 416169 1670 63071125
Cardiogenic shock 47.98 10.70 29 416198 17903 63054892
Hemiparesis 47.97 10.70 49 416178 23233 63049562
Eosinophilia 47.91 10.70 47 416180 22709 63050086
Product storage error 47.88 10.70 19 416208 14937 63057858
Cytopenia 47.85 10.70 9 416218 11592 63061203
Comminuted fracture 47.70 10.70 35 416192 523 63072272
Oral fibroma 47.70 10.70 17 416210 42 63072753
Dental prosthesis placement 47.53 10.70 18 416209 56 63072739
Toothache 47.45 10.70 250 415977 18949 63053846
Schizophrenia 47.41 10.70 5 416222 9947 63062848
Throat tightness 47.29 10.70 56 416171 24831 63047964
Product prescribing error 46.98 10.70 62 416165 26227 63046568
Sjogren's syndrome 46.37 10.70 45 416182 1005 63071790
Carpal tunnel decompression 46.02 10.70 42 416185 866 63071929
Lung neoplasm 46.01 10.70 113 416114 5853 63066942
Spinal fusion surgery 45.98 10.70 109 416118 5519 63067276
Varicose vein operation 45.91 10.70 14 416213 16 63072779
Barrett's oesophagus 45.83 10.70 36 416191 599 63072196
Purulence 45.69 10.70 54 416173 1520 63071275
Oesophageal stenosis 45.55 10.70 79 416148 3187 63069608
Stress 45.53 10.70 256 415971 66911 63005884
Toxic skin eruption 45.32 10.70 14 416213 12871 63059924
Meniscus removal 45.24 10.70 15 416212 27 63072768
Mastication disorder 44.93 10.70 62 416165 2044 63070751
Upper limb fracture 44.84 10.70 244 415983 18724 63054071
Plantar fasciitis 44.63 10.70 85 416142 3690 63069105
Neuroleptic malignant syndrome 44.42 10.70 12 416215 12044 63060751
Adenoidal disorder 44.27 10.70 21 416206 129 63072666
Circulatory collapse 44.27 10.70 47 416180 21891 63050904
Metastases to liver 44.06 10.70 54 416173 23585 63049210
Mood altered 43.60 10.70 21 416206 14722 63058073
Chronic obstructive pulmonary disease 43.53 10.70 614 415613 62072 63010723
Tendon disorder 43.30 10.70 109 416118 5734 63067061
Epilepsy 43.28 10.70 69 416158 26996 63045799
Bladder repair 43.23 10.70 19 416208 95 63072700
Syncope 43.10 10.70 527 415700 116858 62955937
Injection site rash 43.00 10.70 36 416191 18773 63054022
Ejection fraction decreased 42.70 10.70 50 416177 22282 63050513
Enthesopathy 42.68 10.70 139 416088 8475 63064320
Emphysema 42.57 10.70 163 416064 10775 63062020
Akathisia 42.54 10.70 5 416222 9141 63063654
Dislocation of vertebra 42.48 10.70 139 416088 8496 63064299
Phlebolith 42.42 10.70 22 416205 168 63072627
Nightmare 42.34 10.70 38 416189 19156 63053639
Device malfunction 42.29 10.70 33 416194 17824 63054971
Cholecystectomy 42.28 10.70 160 416067 10517 63062278
Abortion induced 42.13 10.70 8 416219 10234 63062561
Traumatic ulcer 42.10 10.70 15 416212 37 63072758
Sputum culture positive 42.10 10.70 61 416166 2106 63070689
Salpingo-oophorectomy bilateral 42.01 10.70 21 416206 147 63072648
Hepatic encephalopathy 42.01 10.70 11 416216 11271 63061524
Dyspnoea exertional 41.88 10.70 228 415999 60074 63012721
Anuria 41.76 10.70 15 416212 12536 63060259
Hormone therapy 41.74 10.70 11 416216 3 63072792
External fixation of fracture 41.74 10.70 11 416216 3 63072792
Myocardial infarction 41.57 10.70 436 415791 99457 62973338
Haematotoxicity 41.51 10.70 6 416221 9370 63063425
Deep vein thrombosis postoperative 41.47 10.70 166 416061 11203 63061592
Affect lability 41.28 10.70 11 416216 11140 63061655
Steroid therapy 41.23 10.70 20 416207 130 63072665
Postmenopausal haemorrhage 41.18 10.70 60 416167 2082 63070713
Incisional drainage 41.11 10.70 29 416198 406 63072389
Oophorectomy 41.06 10.70 32 416195 526 63072269
Dental prosthesis user 40.85 10.70 16 416211 56 63072739
Tongue disorder 40.63 10.70 157 416070 10423 63062372
Gestational diabetes 40.56 10.70 4 416223 8392 63064403
Acne 40.54 10.70 56 416171 23237 63049558
Normal newborn 40.23 10.70 4 416223 8337 63064458
Acute myeloid leukaemia 40.22 10.70 32 416195 17115 63055680
Animal scratch 40.09 10.70 48 416179 1370 63071425
Respiratory depression 39.86 10.70 20 416207 13695 63059100
Muscle twitching 39.84 10.70 42 416185 19626 63053169
Metastases to central nervous system 39.79 10.70 18 416209 13087 63059708
Tachypnoea 39.69 10.70 33 416194 17269 63055526
Lumbar vertebral fracture 39.57 10.70 105 416122 5705 63067090
Osteomyelitis acute 39.56 10.70 23 416204 225 63072570
Metastases to lung 39.52 10.70 17 416210 12733 63060062
Torsade de pointes 39.51 10.70 19 416208 13332 63059463
Impaired fasting glucose 39.48 10.70 23 416204 226 63072569
Ovarian disorder 39.43 10.70 35 416192 695 63072100
Tumour lysis syndrome 39.23 10.70 6 416221 8984 63063811
Transplant rejection 39.22 10.70 11 416216 10769 63062026
Hair follicle tumour benign 39.04 10.70 28 416199 403 63072392
Face oedema 38.92 10.70 45 416182 20167 63052628
Blood lactate dehydrogenase increased 38.82 10.70 57 416170 23059 63049736
Infusion site erythema 38.78 10.70 14 416213 11665 63061130
Intestinal obstruction 38.77 10.70 91 416136 30808 63041987
Bladder disorder 38.74 10.70 138 416089 8808 63063987
Radiotherapy 38.64 10.70 27 416200 372 63072423
Thyroid neoplasm 38.59 10.70 83 416144 3936 63068859
Myocarditis 38.57 10.70 10 416217 10315 63062480
Coma 38.57 10.70 255 415972 64109 63008686
Lymphopenia 38.41 10.70 38 416189 18289 63054506
Acute respiratory failure 38.31 10.70 108 416119 34377 63038418
Hyponatraemia 38.25 10.70 510 415717 111390 62961405
Retinitis 38.24 10.70 108 416119 6088 63066707
Laboratory test abnormal 38.15 10.70 74 416153 26838 63045957
Dermal sinus 38.01 10.70 13 416214 27 63072768
Spondylolysis 37.92 10.70 16 416211 71 63072724
Second primary malignancy 37.87 10.70 4 416223 7949 63064846
Goitre 37.86 10.70 105 416122 5856 63066939
Dermal cyst 37.78 10.70 52 416175 1710 63071085
Swelling face 37.77 10.70 252 415975 63223 63009572
Arteriosclerosis 37.54 10.70 148 416079 9918 63062877
Intermittent claudication 37.54 10.70 53 416174 1786 63071009
Post procedural fever 37.53 10.70 25 416202 317 63072478
Pancreatitis acute 37.39 10.70 76 416151 27090 63045705
Bone fistula 37.35 10.70 15 416212 57 63072738
Skin laceration 37.28 10.70 266 415961 22442 63050353
Skin fissures 37.23 10.70 14 416213 11374 63061421
Back disorder 37.14 10.70 157 416070 10860 63061935
Anti-cyclic citrullinated peptide antibody 37.11 10.70 113 416114 6645 63066150
Hyperbilirubinaemia 36.84 10.70 14 416213 11300 63061495
Joint injury 36.80 10.70 325 415902 29247 63043548
Right ventricular failure 36.77 10.70 35 416192 17153 63055642
Colitis ulcerative 36.76 10.70 72 416155 26019 63046776
Accidental overdose 36.73 10.70 60 416167 23249 63049546
Oesophageal disorder 36.55 10.70 60 416167 2313 63070482
Benign neoplasm of skin 36.53 10.70 19 416208 146 63072649
Breast cyst 36.46 10.70 52 416175 1769 63071026
Hypercalciuria 36.45 10.70 24 416203 298 63072497
Groin pain 36.43 10.70 148 416079 10055 63062740
Tardive dyskinesia 36.37 10.70 6 416221 8496 63064299
Drug-induced liver injury 36.35 10.70 138 416089 40084 63032711
Mental impairment 36.33 10.70 24 416203 14127 63058668
Cerebrovascular accident 36.32 10.70 494 415733 107530 62965265
Cerebral small vessel ischaemic disease 36.31 10.70 36 416191 826 63071969
Post procedural constipation 36.24 10.70 16 416211 81 63072714
Thrombotic microangiopathy 36.21 10.70 12 416215 10549 63062246
Muscle rigidity 36.18 10.70 15 416212 11485 63061310
Drug tolerance 36.13 10.70 114 416113 6835 63065960
Blood pressure abnormal 36.10 10.70 28 416199 15170 63057625
Respiratory disorder 36.03 10.70 133 416094 38949 63033846
Hyperthermia 35.91 10.70 8 416219 9148 63063647
Epicondylitis 35.76 10.70 57 416170 2143 63070652
Uterine prolapse 35.74 10.70 43 416184 1234 63071561
Ischaemic stroke 35.65 10.70 39 416188 17918 63054877
Blood pressure fluctuation 35.64 10.70 169 416058 46148 63026647
Renal injury 35.53 10.70 9 416218 9430 63063365
Sinus disorder 35.44 10.70 279 415948 24274 63048521
Hallucination, auditory 35.36 10.70 20 416207 12804 63059991
Depression 35.35 10.70 1601 414626 194891 62877904
Infection 35.10 10.70 1838 414389 227335 62845460
Hypersomnia 34.98 10.70 40 416187 18015 63054780
Ilium fracture 34.98 10.70 18 416209 135 63072660
Skin burning sensation 34.91 10.70 20 416207 12714 63060081
Haemophagocytic lymphohistiocytosis 34.85 10.70 13 416214 10614 63062181
International normalised ratio increased 34.79 10.70 171 416056 46254 63026541
Blood creatine phosphokinase increased 34.77 10.70 94 416133 30336 63042459
Gingival abscess 34.75 10.70 35 416192 819 63071976
Productive cough 34.64 10.70 257 415970 62951 63009844
Amenorrhoea 34.46 10.70 11 416216 9903 63062892
Metastases to bone 34.17 10.70 53 416174 20966 63051829
Genital haemorrhage 34.13 10.70 4 416223 7328 63065467
Tunnel vision 34.12 10.70 41 416186 1175 63071620
Pulmonary arterial hypertension 33.85 10.70 60 416167 22517 63050278
Mental disorder 33.59 10.70 75 416152 25844 63046951
Kidney infection 33.49 10.70 63 416164 23113 63049682
Injection site haemorrhage 33.48 10.70 68 416159 24246 63048549
Haemoptysis 33.38 10.70 88 416139 28638 63044157
Pulmonary congestion 33.30 10.70 39 416188 17379 63055416
Senile osteoporosis 33.29 10.70 20 416207 209 63072586
Periarthritis 33.26 10.70 56 416171 2205 63070590
Blood potassium decreased 33.13 10.70 152 416075 41874 63030921
Complication of device insertion 33.12 10.70 5 416222 7559 63065236
Neurectomy 33.02 10.70 9 416218 4 63072791
Generalised oedema 32.92 10.70 33 416194 15785 63057010
Hypertensive crisis 32.85 10.70 31 416196 15255 63057540
Head discomfort 32.78 10.70 24 416203 13391 63059404
Red cell distribution width increased 32.67 10.70 14 416213 10510 63062285
Anxiety disorder 32.61 10.70 78 416149 3972 63068823
Aplastic anaemia 32.59 10.70 11 416216 9558 63063237
Radicular pain 32.58 10.70 26 416201 443 63072352
Petechiae 32.51 10.70 26 416201 13871 63058924
Morton's neuralgia 32.34 10.70 14 416213 67 63072728
Infusion site extravasation 32.16 10.70 14 416213 10412 63062383
Gingival pain 32.06 10.70 122 416105 8040 63064755
Bone formation increased 32.04 10.70 18 416209 164 63072631
Bacteraemia 31.94 10.70 40 416187 17308 63055487
Needle issue 31.90 10.70 14 416213 10362 63062433
Oliguria 31.81 10.70 10 416217 9091 63063704
Intentional dose omission 31.78 10.70 7 416220 8068 63064727
Periostitis 31.73 10.70 23 416204 337 63072458
Glomerular filtration rate decreased 31.63 10.70 25 416202 13416 63059379
Neutrophil count increased 31.60 10.70 37 416190 16490 63056305
Synovial fluid analysis 31.55 10.70 57 416170 2376 63070419
Osteogenesis imperfecta 31.53 10.70 29 416198 604 63072191
Product dispensing error 31.53 10.70 14 416213 10291 63062504
Hot flush 31.50 10.70 201 416026 50958 63021837
Dental alveolar anomaly 31.29 10.70 13 416214 55 63072740
Multiple sclerosis 31.20 10.70 71 416156 24301 63048494
Eye swelling 31.17 10.70 69 416158 23849 63048946
Inflammatory marker increased 31.17 10.70 4 416223 6835 63065960
Live birth 31.03 10.70 280 415947 25350 63047445
Hereditary angioedema 30.91 10.70 6 416221 7556 63065239
Paraesthesia oral 30.88 10.70 49 416178 19207 63053588
Cervicobrachial syndrome 30.85 10.70 35 416192 942 63071853
Mammogram abnormal 30.62 10.70 31 416196 730 63072065
Haematocrit decreased 30.59 10.70 143 416084 39197 63033598
Chondromalacia 30.57 10.70 21 416206 281 63072514
Haemodynamic instability 30.55 10.70 11 416216 9179 63063616
Emotional distress 30.51 10.70 110 416117 32439 63040356
Skin haemorrhage 30.43 10.70 14 416213 10080 63062715
Swollen tongue 30.42 10.70 121 416106 34679 63038116
Photosensitivity reaction 30.39 10.70 32 416195 14962 63057833
Immunodeficiency 30.21 10.70 54 416173 20200 63052595
Rhinoplasty 30.13 10.70 9 416218 9 63072786
Liver function test increased 30.02 10.70 112 416115 32699 63040096
Post laminectomy syndrome 30.01 10.70 21 416206 290 63072505
Device occlusion 29.90 10.70 6 416221 7381 63065414
Vertebroplasty 29.80 10.70 22 416205 332 63072463
Gingivectomy 29.74 10.70 8 416219 3 63072792
Localised infection 29.73 10.70 100 416127 30110 63042685
Miosis 29.71 10.70 6 416221 7347 63065448
Bradyphrenia 29.69 10.70 5 416222 6975 63065820
Intentional product use issue 29.69 10.70 1071 415156 126821 62945974
Mental status changes 29.59 10.70 146 416081 39453 63033342
Hemiplegia 29.59 10.70 12 416215 9311 63063484
Granuloma 29.48 10.70 94 416133 5667 63067128
Vascular device infection 29.47 10.70 6 416221 7306 63065489
Progressive multifocal leukoencephalopathy 29.44 10.70 25 416202 12946 63059849
Temperature regulation disorder 29.42 10.70 3 416224 6129 63066666
Atelectasis 29.31 10.70 241 415986 21242 63051553
Left ventricular hypertrophy 29.31 10.70 89 416138 5226 63067569
Knee deformity 29.30 10.70 40 416187 1305 63071490
White blood cell count increased 29.29 10.70 192 416035 48369 63024426
Blood calcium decreased 29.26 10.70 83 416144 26368 63046427
Neuroma 29.26 10.70 24 416203 426 63072369
Leukoplakia 29.25 10.70 14 416213 88 63072707
Melanocytic naevus 29.22 10.70 80 416147 4428 63068367
Lip neoplasm 29.19 10.70 9 416218 11 63072784
Dialysis 29.13 10.70 16 416211 10411 63062384
Mania 29.10 10.70 23 416204 12344 63060451
Injection site induration 29.08 10.70 12 416215 9214 63063581
Hypomagnesaemia 29.05 10.70 94 416133 28643 63044152
Jaw fistula 29.03 10.70 12 416215 50 63072745
Traumatic fracture 29.02 10.70 29 416198 672 63072123
Cervical spinal stenosis 28.97 10.70 52 416175 2156 63070639
Pre-existing condition improved 28.92 10.70 9 416218 8235 63064560
Infusion site swelling 28.77 10.70 14 416213 9756 63063039
Haemorrhoid operation 28.72 10.70 22 416205 352 63072443
Sickle cell anaemia with crisis 28.64 10.70 3 416224 6000 63066795
Avulsion fracture 28.54 10.70 20 416207 277 63072518
Extrapyramidal disorder 28.47 10.70 27 416200 13257 63059538
Dysstasia 28.46 10.70 60 416167 21106 63051689
Trigger finger 28.35 10.70 78 416149 4330 63068465
Poor dental condition 28.35 10.70 24 416203 446 63072349
Ventricular tachycardia 28.26 10.70 55 416172 19924 63052871
Benign breast lump removal 28.24 10.70 7 416220 0 63072795
Acrochordon 28.22 10.70 35 416192 1037 63071758
Pain of skin 28.19 10.70 21 416206 11613 63061182
Lupus vulgaris 28.16 10.70 95 416132 5899 63066896
Joint range of motion decreased 28.16 10.70 331 415896 32097 63040698
Stasis dermatitis 28.13 10.70 29 416198 698 63072097
Rash papular 28.09 10.70 37 416190 15665 63057130
Renal tubular necrosis 28.07 10.70 22 416205 11856 63060939
Nervous system disorder 28.02 10.70 50 416177 18716 63054079
Urethral caruncle 27.93 10.70 13 416214 76 63072719
Blood alkaline phosphatase increased 27.92 10.70 166 416061 42801 63029994
SARS-CoV-2 test positive 27.89 10.70 9 416218 8047 63064748
Sneezing 27.69 10.70 48 416179 18170 63054625
Enterocele 27.63 10.70 12 416215 58 63072737
Psychomotor hyperactivity 27.49 10.70 18 416209 10645 63062150
Bronchial secretion retention 27.47 10.70 58 416169 2715 63070080
Delusion 27.47 10.70 23 416204 11994 63060801
Hyperparathyroidism primary 27.42 10.70 22 416205 378 63072417
Liver function test abnormal 27.32 10.70 194 416033 47987 63024808
Skin cancer 27.26 10.70 148 416079 11347 63061448
Cyst 27.26 10.70 172 416055 13927 63058868
Hypokalaemia 27.06 10.70 498 415729 103306 62969489
Female genital tract fistula 26.97 10.70 8 416219 7551 63065244
Vaginal disorder 26.81 10.70 29 416198 739 63072056
Body temperature increased 26.72 10.70 139 416088 37053 63035742
Labelled drug-drug interaction medication error 26.71 10.70 29 416198 13370 63059425
Therapy change 26.67 10.70 4 416223 6077 63066718
Hyperaesthesia 26.67 10.70 14 416213 9344 63063451
Prescribed underdose 26.65 10.70 305 415922 29384 63043411
Motor dysfunction 26.63 10.70 19 416208 10742 63062053
Inflammation 26.52 10.70 717 415510 81556 62991239
Speech disorder 26.38 10.70 157 416070 40472 63032323
Joint dislocation reduction 26.30 10.70 8 416219 9 63072786
Pharyngitis streptococcal 26.20 10.70 19 416208 10653 63062142
Forearm fracture 26.17 10.70 24 416203 498 63072297
Blood 25-hydroxycholecalciferol decreased 26.09 10.70 12 416215 68 63072727
Tooth infection 26.07 10.70 204 416023 17716 63055079
Raynaud's phenomenon 26.06 10.70 36 416191 1188 63071607
End stage renal disease 25.94 10.70 6 416221 6687 63066108
Paranoia 25.91 10.70 23 416204 11656 63061139
Chondrocalcinosis 25.85 10.70 30 416197 828 63071967
Increased tendency to bruise 25.80 10.70 137 416090 10415 63062380
Candida infection 25.80 10.70 97 416130 28254 63044541
Vitamin B12 deficiency 25.76 10.70 85 416142 5218 63067577
Limb injury 25.76 10.70 268 415959 25209 63047586
Taste disorder 25.68 10.70 31 416196 13631 63059164
Glycosylated haemoglobin increased 25.65 10.70 26 416201 12372 63060423
Ventricular fibrillation 25.58 10.70 24 416203 11843 63060952
Injection site extravasation 25.53 10.70 13 416214 8828 63063967
Skin abrasion 25.52 10.70 125 416102 9204 63063591
Hypertransaminasaemia 25.47 10.70 6 416221 6603 63066192
Oesophageal perforation 25.45 10.70 21 416206 376 63072419
Drug level decreased 25.45 10.70 10 416217 7909 63064886
Infective pulmonary exacerbation of cystic fibrosis 25.41 10.70 13 416214 8804 63063991
Cyanosis 25.39 10.70 45 416182 16890 63055905
Incorrect product administration duration 25.30 10.70 23 416204 11523 63061272
Lip swelling 25.30 10.70 111 416116 30952 63041843
Electrolyte imbalance 25.28 10.70 59 416168 20017 63052778
Mixed incontinence 25.26 10.70 12 416215 74 63072721
Autoimmune disorder 25.24 10.70 196 416031 16981 63055814
Suspected suicide 25.24 10.70 6 416221 6562 63066233
Osteosclerosis 25.21 10.70 69 416158 3819 63068976
Increased appetite 25.17 10.70 16 416211 9614 63063181
Rotator cuff repair 25.17 10.70 48 416179 2086 63070709
Iron deficiency anaemia 25.12 10.70 220 416007 19749 63053046
Inappropriate antidiuretic hormone secretion 25.12 10.70 39 416188 15423 63057372
Oesophageal discomfort 25.12 10.70 16 416211 187 63072608
Cervical polyp 25.03 10.70 17 416210 223 63072572
Cerebral haemorrhage 24.91 10.70 110 416117 30619 63042176
Pharyngeal oedema 24.88 10.70 32 416195 13689 63059106
Intestinal perforation 24.85 10.70 25 416202 11938 63060857
Uterine dilation and curettage 24.80 10.70 31 416196 926 63071869
Anger 24.78 10.70 27 416200 12429 63060366
Lip dry 24.69 10.70 180 416047 15290 63057505
Cerebrovascular disorder 24.62 10.70 55 416172 2677 63070118
Peripheral coldness 24.61 10.70 26 416201 12139 63060656
Haemodialysis 24.60 10.70 14 416213 8933 63063862
Feeding disorder 24.40 10.70 31 416196 13331 63059464
Poor venous access 24.30 10.70 37 416190 14748 63058047
Pathogen resistance 24.28 10.70 6 416221 6392 63066403
Urine calcium increased 24.25 10.70 11 416216 60 63072735
Dupuytren's contracture 24.24 10.70 12 416215 82 63072713
Bedridden 24.23 10.70 22 416205 11029 63061766
Grief reaction 24.22 10.70 17 416210 236 63072559
Traumatic occlusion 24.20 10.70 6 416221 0 63072795
Radiotherapy to breast 24.20 10.70 6 416221 0 63072795
Tendon sheath lesion excision 24.20 10.70 6 416221 0 63072795
Gastrooesophageal cancer 24.20 10.70 6 416221 0 63072795
Atrial fibrillation 24.11 10.70 581 415646 116055 62956740
Hallucination, visual 24.07 10.70 57 416170 19241 63053554
Maternal drugs affecting foetus 24.05 10.70 3 416224 5239 63067556
Cataract nuclear 24.03 10.70 30 416197 895 63071900
Respiratory syncytial virus infection 24.02 10.70 8 416219 7010 63065785
Hypertensive heart disease 23.96 10.70 51 416176 2401 63070394
Dental pulp disorder 23.94 10.70 7 416220 6 63072789
Fracture reduction 23.94 10.70 7 416220 6 63072789
Pneumonia viral 23.87 10.70 11 416216 7911 63064884
Menopausal symptoms 23.83 10.70 51 416176 2410 63070385
Shock haemorrhagic 23.80 10.70 18 416209 9877 63062918
Denture wearer 23.68 10.70 16 416211 208 63072587
Myofascial pain syndrome 23.57 10.70 49 416178 2269 63070526
Jaundice 23.53 10.70 105 416122 29146 63043649
Joint arthroplasty 23.39 10.70 54 416173 2687 63070108
Adenoidectomy 23.37 10.70 13 416214 116 63072679
Cardiac failure acute 23.32 10.70 17 416210 9506 63063289
Balance disorder 23.28 10.70 401 415826 84021 62988774
Enchondromatosis 23.27 10.70 11 416216 67 63072728
Multiple fractures 23.24 10.70 115 416112 8503 63064292
Aspergillus infection 23.22 10.70 12 416215 8081 63064714
Lipoma 23.11 10.70 50 416177 2381 63070414
Vertigo positional 23.08 10.70 55 416172 2794 63070001
Osteitis deformans 23.05 10.70 16 416211 218 63072577
Neuritis 23.02 10.70 31 416196 998 63071797
Incision site haematoma 23 10.70 11 416216 69 63072726
Dermatitis atopic 22.99 10.70 18 416209 9706 63063089
Stress cardiomyopathy 22.97 10.70 17 416210 9433 63063362
Skin plaque 22.90 10.70 13 416214 8307 63064488
Wound complication 22.82 10.70 65 416162 3682 63069113
Retching 22.79 10.70 38 416189 14607 63058188
Sialoadenitis 22.74 10.70 40 416187 1632 63071163
Palatal disorder 22.73 10.70 17 416210 262 63072533
Renal disorder 22.71 10.70 125 416102 32849 63039946
Klebsiella infection 22.71 10.70 14 416213 8552 63064243
General physical health deterioration 22.66 10.70 1572 414655 199830 62872965
Dermatitis acneiform 22.58 10.70 3 416224 4993 63067802
Bone scan abnormal 22.54 10.70 20 416207 397 63072398
Immune reconstitution inflammatory syndrome 22.52 10.70 6 416221 6078 63066717
Metatarsalgia 22.51 10.70 17 416210 266 63072529
Sinus tarsi syndrome 22.51 10.70 7 416220 9 63072786
Leukoplakia oral 22.47 10.70 14 416213 157 63072638
Eczema 22.47 10.70 122 416105 32169 63040626
Apathy 22.46 10.70 15 416212 8779 63064016
Emotional disorder 22.46 10.70 33 416194 13346 63059449
Rhinitis perennial 22.45 10.70 9 416218 34 63072761
Dermatitis bullous 22.43 10.70 14 416213 8494 63064301
X-ray abnormal 22.42 10.70 109 416118 8001 63064794
Hospice care 22.41 10.70 12 416215 7920 63064875
Glucose tolerance impaired 22.38 10.70 94 416133 6483 63066312
Intermenstrual bleeding 22.38 10.70 12 416215 7914 63064881
Exposure during pregnancy 22.36 10.70 814 415413 154733 62918062
Tubulointerstitial nephritis 22.35 10.70 62 416165 19841 63052954
Central nervous system lesion 22.35 10.70 22 416205 10613 63062182
Presbyopia 22.35 10.70 21 416206 450 63072345
Jaundice cholestatic 22.33 10.70 10 416217 7314 63065481
Hepatic function abnormal 22.32 10.70 147 416080 36995 63035800
Dementia Alzheimer's type 22.31 10.70 31 416196 1029 63071766
Loss of employment 22.30 10.70 47 416180 2197 63070598
Product dose omission in error 22.27 10.70 11 416216 7601 63065194
Spondylitis 22.24 10.70 71 416156 4283 63068512
Malpositioned teeth 22.11 10.70 8 416219 21 63072774
Tumour marker increased 22.10 10.70 3 416224 4912 63067883
Catheter site infection 22.10 10.70 3 416224 4911 63067884
Red blood cell sedimentation rate increased 21.98 10.70 408 415819 43574 63029221
Proteinuria 21.98 10.70 59 416168 19086 63053709
Hypocalcaemia 21.96 10.70 120 416107 31593 63041202
Rash 21.94 10.70 4084 412143 556787 62516008
Sensitivity to weather change 21.88 10.70 10 416217 7227 63065568
Cataract cortical 21.87 10.70 9 416218 37 63072758
Osteorrhagia 21.79 10.70 6 416221 3 63072792
Electrocardiogram QRS complex prolonged 21.71 10.70 6 416221 5932 63066863
Tooth impacted 21.68 10.70 17 416210 282 63072513
Gingival swelling 21.63 10.70 71 416156 4347 63068448
Anhedonia 21.60 10.70 24 416203 10950 63061845
Wound secretion 21.56 10.70 73 416154 4541 63068254
White blood cell count abnormal 21.56 10.70 7 416220 6235 63066560
Blood creatinine decreased 21.43 10.70 5 416222 5540 63067255
Drug dose omission by device 21.42 10.70 3 416224 4798 63067997
Rectal polyp 21.38 10.70 33 416194 1206 63071589
Odontogenic cyst 21.34 10.70 8 416219 24 63072771
Bone sarcoma 21.33 10.70 7 416220 12 63072783
Laryngeal ulceration 21.33 10.70 7 416220 12 63072783
Splenic granuloma 21.33 10.70 7 416220 12 63072783
Hepatomegaly 21.28 10.70 28 416199 11861 63060934
Bone atrophy 21.27 10.70 10 416217 60 63072735
Blood test abnormal 21.27 10.70 44 416183 15585 63057210
Mitral valve incompetence 21.19 10.70 209 416018 19385 63053410
Alanine aminotransferase increased 21.15 10.70 518 415709 103252 62969543
Spinal claudication 21.14 10.70 10 416217 61 63072734
Glaucoma 21.11 10.70 203 416024 18702 63054093
Graft versus host disease 20.99 10.70 9 416218 6754 63066041
Atrioventricular block 20.98 10.70 12 416215 7635 63065160
Cold sweat 20.93 10.70 29 416198 12018 63060777
Embolism 20.85 10.70 13 416214 7893 63064902
Product preparation error 20.75 10.70 7 416220 6085 63066710
Respiratory acidosis 20.74 10.70 9 416218 6706 63066089
Menstruation irregular 20.68 10.70 10 416217 6994 63065801
Incision site cellulitis 20.55 10.70 13 416214 150 63072645
Post transplant lymphoproliferative disorder 20.55 10.70 4 416223 5027 63067768
Clonus 20.45 10.70 3 416224 4633 63068162
Traumatic arthritis 20.42 10.70 8 416219 28 63072767
Trigeminal neuralgia 20.42 10.70 60 416167 3459 63069336
Bladder pain 20.28 10.70 46 416181 2262 63070533
Dystrophic calcification 20.25 10.70 12 416215 122 63072673
Disseminated intravascular coagulation 20.19 10.70 61 416166 18990 63053805
Hormone level abnormal 20.19 10.70 48 416179 2435 63070360
Fibrous dysplasia of bone 20.17 10.70 5 416222 0 63072795
Chondroplasty 20.17 10.70 5 416222 0 63072795
Apicectomy 20.17 10.70 5 416222 0 63072795
Clavicle fracture 20.14 10.70 59 416168 3396 63069399
Maternal exposure timing unspecified 20.13 10.70 96 416131 6991 63065804
Menstrual disorder 20.13 10.70 5 416222 5308 63067487
Haemolytic anaemia 20.09 10.70 22 416205 10103 63062692
Face injury 20.05 10.70 57 416170 3225 63069570
Cholecystitis chronic 20.02 10.70 23 416204 10338 63062457
Tooth resorption 20.01 10.70 9 416218 48 63072747
Fibroadenoma of breast 19.96 10.70 20 416207 465 63072330
Labile hypertension 19.93 10.70 20 416207 466 63072329
Oesophageal ulcer haemorrhage 19.89 10.70 18 416209 367 63072428
Peri-implantitis 19.89 10.70 10 416217 71 63072724
Hyperglycaemia 19.84 10.70 177 416050 41690 63031105
Otitis externa 19.80 10.70 39 416188 1736 63071059
Wound drainage 19.76 10.70 26 416201 818 63071977
Nasal disorder 19.75 10.70 52 416175 2812 63069983
Seronegative arthritis 19.72 10.70 64 416163 3895 63068900
Hyperammonaemia 19.67 10.70 5 416222 5227 63067568
Intervertebral disc space narrowing 19.55 10.70 29 416198 1023 63071772
Expired product administered 19.54 10.70 8 416219 6173 63066622
Large intestine benign neoplasm 19.51 10.70 11 416216 101 63072694
Middle insomnia 19.50 10.70 33 416194 12610 63060185
Benign neoplasm 19.49 10.70 28 416199 959 63071836
Staphylococcal bacteraemia 19.46 10.70 6 416221 5524 63067271
Upper respiratory tract infection 19.44 10.70 400 415827 81647 62991148
Lymphadenopathy 19.38 10.70 160 416067 38298 63034497
Staphylococcal infection 19.29 10.70 175 416052 41081 63031714
Inguinal hernia repair 19.28 10.70 9 416218 53 63072742
Injection site discolouration 19.23 10.70 14 416213 7834 63064961
Respiration abnormal 19.19 10.70 9 416218 6408 63066387
X-ray of pelvis and hip abnormal 19.18 10.70 7 416220 19 63072776
Parathyroidectomy 19.17 10.70 15 416212 248 63072547
Foot operation 19.15 10.70 96 416131 7135 63065660
Lipase increased 19.11 10.70 22 416205 9878 63062917
Personality change 19.05 10.70 11 416216 6962 63065833
Walking aid user 19.04 10.70 128 416099 10589 63062206
Muscle spasms 19.03 10.70 833 415394 155317 62917478
Acute generalised exanthematous pustulosis 19.00 10.70 27 416200 11072 63061723
Drug hypersensitivity 18.95 10.70 1766 414461 308921 62763874
Ventricular septal defect 18.93 10.70 3 416224 4375 63068420
Pulmonary hypertension 18.91 10.70 154 416073 36969 63035826
Atrial septal defect 18.87 10.70 11 416216 6927 63065868
Infusion site haemorrhage 18.86 10.70 5 416222 5081 63067714
Mixed liver injury 18.85 10.70 4 416223 4731 63068064
Incorrect dose administered by device 18.75 10.70 3 416224 4345 63068450
Gastrointestinal toxicity 18.72 10.70 14 416213 7727 63065068
Insomnia 18.72 10.70 1188 415039 214064 62858731
Thirst 18.72 10.70 40 416187 14001 63058794
Hunger 18.64 10.70 6 416221 5373 63067422
Viral infection 18.60 10.70 147 416080 35516 63037279
Gastrointestinal infection 18.60 10.70 20 416207 9261 63063534
Hepatic necrosis 18.58 10.70 7 416220 5680 63067115
Blood pressure diastolic decreased 18.57 10.70 81 416146 22625 63050170
Breath odour 18.50 10.70 32 416195 1288 63071507
Oophorectomy bilateral 18.49 10.70 9 416218 59 63072736
Uterovaginal prolapse 18.48 10.70 10 416217 84 63072711
Laryngitis 18.36 10.70 181 416046 16786 63056009
Condition aggravated 18.34 10.70 2333 413894 399884 62672911
Full blood count abnormal 18.33 10.70 127 416100 31590 63041205
Pulmonary thrombosis 18.29 10.70 18 416209 8684 63064111
Polyneuropathy 18.27 10.70 43 416184 14546 63058249
Labyrinthitis 18.23 10.70 45 416182 2338 63070457
Nystagmus 18.18 10.70 9 416218 6211 63066584
Persistent depressive disorder 18.17 10.70 28 416199 1022 63071773
Breast mass 18.12 10.70 101 416126 7821 63064974
Pneumocystis jirovecii pneumonia 18.04 10.70 54 416173 16860 63055935
Haemolysis 18.03 10.70 11 416216 6757 63066038
Brain injury 18.01 10.70 12 416215 7031 63065764
Device extrusion 17.98 10.70 7 416220 24 63072771
Breast cancer metastatic 17.96 10.70 32 416195 11986 63060809
Encephalitis 17.94 10.70 19 416208 8861 63063934
Left ventricular dysfunction 17.84 10.70 32 416195 11956 63060839
Intestinal adhesion lysis 17.84 10.70 5 416222 3 63072792
Osteodystrophy 17.84 10.70 5 416222 3 63072792
Oral discharge 17.83 10.70 12 416215 155 63072640
Breast cancer female 17.76 10.70 39 416188 13520 63059275
Thermohypoaesthesia 17.76 10.70 11 416216 122 63072673
Euphoric mood 17.75 10.70 5 416222 4882 63067913
Bone infarction 17.73 10.70 16 416211 325 63072470
Oesophagitis chemical 17.69 10.70 6 416221 12 63072783
Epstein-Barr virus infection 17.68 10.70 16 416211 8034 63064761
Flatulence 17.65 10.70 144 416083 34558 63038237
Joint surgery 17.65 10.70 17 416210 376 63072419
Hypoparathyroidism 17.63 10.70 22 416205 656 63072139
Acidosis 17.62 10.70 29 416198 11204 63061591
Scab 17.57 10.70 15 416212 7748 63065047
Repetitive strain injury 17.57 10.70 12 416215 159 63072636
Mouth cyst 17.45 10.70 10 416217 95 63072700
Vascular headache 17.44 10.70 8 416219 45 63072750
Sensory loss 17.43 10.70 25 416202 10213 63062582
Coma scale abnormal 17.41 10.70 6 416221 5147 63067648
Carotid endarterectomy 17.38 10.70 11 416216 127 63072668
Catatonia 17.38 10.70 4 416223 4473 63068322
Lenticular opacities 17.38 10.70 14 416213 242 63072553
Breast fibrosis 17.35 10.70 7 416220 27 63072768
Pulmonary haemorrhage 17.35 10.70 13 416214 7168 63065627
Vulvovaginal dryness 17.35 10.70 50 416177 2851 63069944
Abdominal pain lower 17.33 10.70 98 416129 25580 63047215
Benign bone neoplasm 17.32 10.70 9 416218 69 63072726
Skin graft 17.31 10.70 21 416206 608 63072187
Arrhythmia 17.31 10.70 163 416064 37977 63034818
Blood magnesium decreased 17.26 10.70 38 416189 13160 63059635
Cystitis 17.23 10.70 255 415972 54736 63018059
Lacunar infarction 17.23 10.70 54 416173 3226 63069569
Oesophageal injury 17.16 10.70 8 416219 47 63072748
Toxic encephalopathy 17.10 10.70 11 416216 6568 63066227
Spinal decompression 17.05 10.70 14 416213 249 63072546
Uterine leiomyoma 17.03 10.70 111 416116 9087 63063708
Sight disability 17.02 10.70 11 416216 132 63072663
Acute pulmonary oedema 17 10.70 17 416210 8141 63064654
Coagulopathy 16.98 10.70 73 416154 20471 63052324
Neutrophilia 16.98 10.70 4 416223 4402 63068393
Hypovolaemic shock 16.83 10.70 10 416217 6231 63066564
Ketoacidosis 16.82 10.70 4 416223 4374 63068421
Immune thrombocytopenia 16.79 10.70 27 416200 10529 63062266
Immobile 16.78 10.70 9 416218 5934 63066861
Hyperkeratosis 16.72 10.70 81 416146 5937 63066858
Disturbance in social behaviour 16.68 10.70 3 416224 3990 63068805
Blood sodium decreased 16.67 10.70 92 416135 24160 63048635
Bone cyst 16.65 10.70 42 416185 2212 63070583
Tendon sheath incision 16.60 10.70 9 416218 76 63072719
Rash pustular 16.57 10.70 14 416213 7268 63065527
Mastoid disorder 16.51 10.70 6 416221 16 63072779
Neurosensory hypoacusis 16.51 10.70 13 416214 217 63072578
Incorrect drug administration rate 16.50 10.70 3 416224 3959 63068836
Osteocalcin decreased 16.49 10.70 8 416219 52 63072743
Ammonia increased 16.48 10.70 5 416222 4651 63068144
Acute myocardial infarction 16.48 10.70 133 416094 31991 63040804
Restless legs syndrome 16.46 10.70 190 416037 18341 63054454
Blood potassium increased 16.43 10.70 63 416164 18246 63054549
Cervical radiculopathy 16.41 10.70 27 416200 1043 63071752
Gingival ulceration 16.37 10.70 25 416202 905 63071890
Wrong product administered 16.33 10.70 10 416217 6131 63066664
Spinal deformity 16.33 10.70 27 416200 1047 63071748
Actinic elastosis 16.25 10.70 6 416221 17 63072778
Intestinal ischaemia 16.22 10.70 15 416212 7453 63065342
Kidney transplant rejection 16.22 10.70 4 416223 4267 63068528
Aortic valve incompetence 16.21 10.70 80 416147 5908 63066887
Drug specific antibody present 16.15 10.70 4 416223 4255 63068540
Loss of anatomical alignment after fracture reduction 16.14 10.70 4 416223 0 63072795
Reaction to food additive 16.14 10.70 4 416223 0 63072795
Metatarsus primus varus 16.14 10.70 4 416223 0 63072795
Arthrotomy 16.14 10.70 4 416223 0 63072795
Impacted fracture 16.14 10.70 4 416223 0 63072795
Fracture debridement 16.14 10.70 4 416223 0 63072795
Uterine cervix atrophy 16.14 10.70 4 416223 0 63072795
Lipoma of breast 16.14 10.70 4 416223 0 63072795
Oesophageal haemorrhage 16.13 10.70 19 416208 533 63072262
Vaginal discharge 16.12 10.70 22 416205 9176 63063619
Tongue geographic 16.11 10.70 9 416218 81 63072714
Therapeutic response decreased 16.08 10.70 295 415932 61230 63011565
Upper-airway cough syndrome 16.07 10.70 129 416098 11289 63061506
Benign breast neoplasm 16.01 10.70 29 416198 1211 63071584
Chromaturia 16.00 10.70 56 416171 16661 63056134
Mastectomy 16.00 10.70 34 416193 1599 63071196
Breast cancer stage I 15.98 10.70 13 416214 6876 63065919
Peritonitis bacterial 15.95 10.70 6 416221 4873 63067922
Transplant dysfunction 15.91 10.70 6 416221 4866 63067929
Urinary bladder polyp 15.89 10.70 8 416219 57 63072738
Thalassaemia beta 15.84 10.70 5 416222 7 63072788
Pain in extremity 15.83 10.70 2440 413787 329046 62743749
Purulent discharge 15.81 10.70 67 416160 4639 63068156
Abdominal hernia 15.80 10.70 70 416157 4942 63067853
Hepatitis acute 15.80 10.70 22 416205 9098 63063697
Nail operation 15.78 10.70 24 416203 866 63071929
Diplopia 15.77 10.70 91 416136 23637 63049158
Vitreous degeneration 15.77 10.70 6 416221 19 63072776
Injection site nodule 15.77 10.70 3 416224 3832 63068963
Bladder prolapse 15.75 10.70 40 416187 2116 63070679
Aortic stenosis 15.74 10.70 70 416157 4950 63067845
Tonsillitis 15.73 10.70 9 416218 5726 63067069
Weight fluctuation 15.73 10.70 25 416202 9794 63063001
Device leakage 15.71 10.70 14 416213 7082 63065713
Foreign body 15.67 10.70 42 416185 2296 63070499
Tooth discolouration 15.62 10.70 25 416202 943 63071852
Pulmonary granuloma 15.62 10.70 31 416196 1388 63071407
Dermatitis exfoliative generalised 15.60 10.70 3 416224 3804 63068991
Food allergy 15.60 10.70 32 416195 11369 63061426
Bronchopulmonary aspergillosis allergic 15.57 10.70 41 416186 2217 63070578
Galactorrhoea 15.57 10.70 4 416223 4151 63068644
Blood urea increased 15.55 10.70 105 416122 26274 63046521
Aortic aneurysm 15.55 10.70 58 416169 3786 63069009
Cushingoid 15.47 10.70 102 416125 8383 63064412
Bronchitis chronic 15.43 10.70 63 416164 4290 63068505
Parkinsonism 15.42 10.70 28 416199 10411 63062384
Peritonitis 15.41 10.70 59 416168 17095 63055700
Salivary gland mass 15.40 10.70 9 416218 89 63072706
Gouty arthritis 15.34 10.70 19 416208 562 63072233
Hypersensitivity vasculitis 15.33 10.70 4 416223 4108 63068687
Skin infection 15.22 10.70 49 416178 14953 63057842
Otitis media 15.19 10.70 68 416159 4823 63067972
Catheter site pain 15.18 10.70 6 416221 4729 63068066
Vaginal prolapse 15.18 10.70 17 416210 451 63072344
Insulin-requiring type 2 diabetes mellitus 15.15 10.70 9 416218 92 63072703
Paralysis 15.12 10.70 26 416201 9874 63062921
Reflux laryngitis 15.11 10.70 12 416215 203 63072592
Ureterolithiasis 15.08 10.70 37 416190 1915 63070880
Tympanosclerosis 15.08 10.70 5 416222 9 63072786
Benign gastric neoplasm 15.08 10.70 5 416222 9 63072786
Initial insomnia 15.07 10.70 11 416216 6146 63066649
Product substitution issue 15.03 10.70 54 416173 15942 63056853
Ear congestion 15.03 10.70 46 416181 2713 63070082
Obesity 15.02 10.70 278 415949 29674 63043121
Hip deformity 15.01 10.70 12 416215 205 63072590
Peripheral sensory neuropathy 14.99 10.70 16 416211 7435 63065360
Breast hyperplasia 14.97 10.70 14 416213 298 63072497
Parathyroid disorder 14.92 10.70 20 416207 641 63072154
Eustachian tube disorder 14.90 10.70 9 416218 95 63072700
Jaw clicking 14.90 10.70 6 416221 23 63072772
Insurance issue 14.89 10.70 11 416216 6110 63066685
Carcinoid tumour pulmonary 14.88 10.70 17 416210 461 63072334
Vertigo 14.77 10.70 290 415937 59597 63013198
Personality disorder 14.72 10.70 10 416217 5801 63066994
Staphylococcal sepsis 14.69 10.70 19 416208 8109 63064686
Eyelid oedema 14.69 10.70 29 416198 10450 63062345
Colorectal cancer 14.67 10.70 3 416224 3642 63069153
Cerebral infarction 14.64 10.70 94 416133 23799 63048996
Anal abscess 14.64 10.70 6 416221 4626 63068169
Urosepsis 14.60 10.70 67 416160 18457 63054338
Bronchospasm 14.53 10.70 61 416166 17219 63055576
Bone trimming 14.51 10.70 6 416221 25 63072770
Ataxia 14.48 10.70 51 416176 15144 63057651
Symphysiolysis 14.43 10.70 5 416222 11 63072784
Coronavirus infection 14.43 10.70 5 416222 4273 63068522
Facial bones fracture 14.41 10.70 58 416169 3924 63068871
Tongue oedema 14.40 10.70 6 416221 4580 63068215
Major depression 14.39 10.70 96 416131 7922 63064873
Dermatitis exfoliative 14.37 10.70 9 416218 5450 63067345
Cardiac failure congestive 14.36 10.70 479 415748 91954 62980841
Parathyroid tumour benign 14.34 10.70 21 416206 732 63072063
Poor personal hygiene 14.24 10.70 14 416213 318 63072477
Bursa disorder 14.21 10.70 11 416216 179 63072616
Chondrocalcinosis pyrophosphate 14.20 10.70 27 416200 1171 63071624
Product administration interrupted 14.13 10.70 7 416220 4829 63067966
Urine calcium decreased 14.13 10.70 5 416222 12 63072783
Presbyoesophagus 14.13 10.70 5 416222 12 63072783
Artificial crown procedure 14.13 10.70 14 416213 321 63072474
Hypergammaglobulinaemia benign monoclonal 14.11 10.70 21 416206 743 63072052
Elbow operation 14.09 10.70 14 416213 322 63072473
Musculoskeletal pain 14.08 10.70 740 415487 91537 62981258
Large intestinal polypectomy 14.04 10.70 12 416215 226 63072569
Skin reaction 14.04 10.70 50 416177 14799 63057996
Intervertebral disc displacement 14.03 10.70 16 416211 433 63072362
Electrocardiogram ST-T change 13.99 10.70 25 416202 1033 63071762
Substance abuse 13.98 10.70 7 416220 4800 63067995
Immune system disorder 13.97 10.70 27 416200 9807 63062988
Faeces discoloured 13.97 10.70 68 416159 18441 63054354
Cytomegalovirus viraemia 13.94 10.70 10 416217 5639 63067156
Joint irrigation 13.92 10.70 4 416223 3 63072792
Panic reaction 13.87 10.70 5 416222 4169 63068626
Nervousness 13.80 10.70 133 416094 30846 63041949
Meningitis 13.79 10.70 16 416211 7161 63065634
Poliomyelitis 13.77 10.70 7 416220 51 63072744
Demyelination 13.77 10.70 15 416212 6905 63065890
Ventricular arrhythmia 13.75 10.70 4 416223 3824 63068971
Visual impairment 13.74 10.70 435 415792 84011 62988784
Pseudarthrosis 13.74 10.70 16 416211 443 63072352
Sudden death 13.73 10.70 30 416197 10419 63062376
Hypoventilation 13.71 10.70 7 416220 4747 63068048
Hypereosinophilic syndrome 13.67 10.70 13 416214 283 63072512
Sleep disorder due to a general medical condition 13.66 10.70 38 416189 12150 63060645
Parathyroid gland operation 13.65 10.70 6 416221 30 63072765
Tooth dislocation 13.65 10.70 6 416221 30 63072765
Cardiomyopathy 13.62 10.70 64 416163 17520 63055275
Neoplasm skin 13.59 10.70 31 416196 1530 63071265
Hormone replacement therapy 13.59 10.70 5 416222 14 63072781
Subarachnoid haemorrhage 13.57 10.70 48 416179 14235 63058560
Respiratory rate increased 13.55 10.70 45 416182 13603 63059192
Extra dose administered 13.50 10.70 13 416214 6337 63066458
Leukoencephalopathy 13.49 10.70 6 416221 4407 63068388
Anticoagulant therapy 13.49 10.70 6 416221 31 63072764
Retinal operation 13.49 10.70 6 416221 31 63072764
Nephropathy toxic 13.49 10.70 26 416201 9453 63063342
Umbilical hernia repair 13.45 10.70 8 416219 82 63072713
Device intolerance 13.45 10.70 8 416219 82 63072713
Bone marrow oedema 13.36 10.70 27 416200 1225 63071570
Troponin increased 13.35 10.70 29 416198 10092 63062703
Erosive oesophagitis 13.34 10.70 33 416194 1717 63071078
Callus formation delayed 13.34 10.70 5 416222 15 63072780
Coordination abnormal 13.27 10.70 46 416181 13727 63059068
Heart rate abnormal 13.24 10.70 8 416219 4939 63067856
Psychiatric symptom 13.22 10.70 9 416218 5214 63067581
Abscess neck 13.15 10.70 19 416208 654 63072141
Oesophageal irritation 13.13 10.70 9 416218 120 63072675
Urine abnormality 13.12 10.70 16 416211 7003 63065792
Osteoporotic fracture 13.11 10.70 54 416173 3692 63069103
Procedural hypotension 13.10 10.70 26 416201 1164 63071631
Dental discomfort 13.03 10.70 16 416211 469 63072326
Grip strength decreased 13.03 10.70 212 416015 22075 63050720
Pyogenic granuloma 13.02 10.70 13 416214 301 63072494
Decreased immune responsiveness 13.01 10.70 8 416219 4893 63067902
Proctitis 12.95 10.70 10 416217 5431 63067364
Internal haemorrhage 12.94 10.70 9 416218 5156 63067639
Presyncope 12.93 10.70 118 416109 27667 63045128
Skin mass 12.89 10.70 12 416215 5943 63066852
Cystocele repair 12.87 10.70 5 416222 17 63072778
Device related infection 12.87 10.70 95 416132 23297 63049498
Parosmia 12.86 10.70 13 416214 6193 63066602
Breast cancer stage III 12.85 10.70 114 416113 10272 63062523
Heparin-induced thrombocytopenia 12.84 10.70 7 416220 4575 63068220
Periorbital oedema 12.84 10.70 11 416216 5673 63067122
Drug level below therapeutic 12.84 10.70 8 416219 4858 63067937
Thinking abnormal 12.83 10.70 32 416195 10611 63062184
Vascular operation 12.82 10.70 9 416218 125 63072670
Haemorrhage intracranial 12.81 10.70 45 416182 13374 63059421
Granulocytopenia 12.79 10.70 11 416216 5661 63067134
Haemoglobin increased 12.75 10.70 4 416223 3642 63069153
Vascular insufficiency 12.74 10.70 12 416215 258 63072537
Pelvic floor muscle weakness 12.72 10.70 7 416220 61 63072734
Breast operation 12.72 10.70 16 416211 481 63072314
Mammoplasty 12.70 10.70 17 416210 544 63072251
Diarrhoea haemorrhagic 12.70 10.70 25 416202 9017 63063778
Stomatitis necrotising 12.64 10.70 9 416218 128 63072667
Acute coronary syndrome 12.56 10.70 30 416197 10096 63062699
Piriformis syndrome 12.55 10.70 10 416217 170 63072625
Ovarian cystectomy 12.55 10.70 10 416217 170 63072625
Dysplastic naevus syndrome 12.51 10.70 4 416223 6 63072789
Keratomileusis 12.51 10.70 4 416223 6 63072789
Impaired gastric emptying 12.51 10.70 31 416196 10301 63062494
Blood albumin decreased 12.49 10.70 52 416175 14714 63058081
Hyperventilation 12.46 10.70 13 416214 6103 63066692
Sebaceous hyperplasia 12.45 10.70 5 416222 19 63072776
Hepatitis toxic 12.44 10.70 3 416224 3250 63069545
Respiratory tract infection 12.43 10.70 194 416033 41289 63031506
Device deployment issue 12.42 10.70 5 416222 3897 63068898
Injection site haematoma 12.32 10.70 16 416211 6816 63065979
Meralgia paraesthetica 12.32 10.70 15 416212 436 63072359
Renal cancer 12.28 10.70 11 416216 5551 63067244
Medical device pain 12.26 10.70 30 416197 1550 63071245
Lithotripsy 12.25 10.70 5 416222 20 63072775
Sacroiliitis 12.24 10.70 48 416179 3209 63069586
Bradypnoea 12.23 10.70 4 416223 3546 63069249
Plasma cell myeloma recurrent 12.22 10.70 3 416224 3210 63069585
Gastrointestinal tract adenoma 12.22 10.70 13 416214 325 63072470
Neurogenic bowel 12.18 10.70 9 416218 136 63072659
Cancer pain 12.17 10.70 3 416224 3202 63069593
Respiratory rate decreased 12.15 10.70 4 416223 3531 63069264
Modified radical mastectomy 12.14 10.70 4 416223 7 63072788
Hyperuricosuria 12.14 10.70 4 416223 7 63072788
Myofascitis 12.14 10.70 4 416223 7 63072788
Vascular skin disorder 12.14 10.70 4 416223 7 63072788
Benign neoplasm of spinal cord 12.10 10.70 3 416224 0 63072795
Traumatic arthropathy 12.10 10.70 3 416224 0 63072795
Spinal corpectomy 12.10 10.70 3 416224 0 63072795
Articular disc disorder 12.10 10.70 3 416224 0 63072795
Epidural fibrosis 12.10 10.70 3 416224 0 63072795
Femoral hernia repair 12.10 10.70 3 416224 0 63072795
Dental examination abnormal 12.10 10.70 3 416224 0 63072795
Deafness traumatic 12.10 10.70 3 416224 0 63072795
Tarsal tunnel decompression 12.10 10.70 3 416224 0 63072795
Intestinal mucosal tear 12.10 10.70 3 416224 0 63072795
Erythroplasia 12.10 10.70 3 416224 0 63072795
Alcohol detoxification 12.10 10.70 3 416224 0 63072795
Mastoid abscess 12.10 10.70 3 416224 0 63072795
Prolapse repair 12.10 10.70 3 416224 0 63072795
Infusion site pruritus 12.10 10.70 13 416214 6022 63066773
Musculoskeletal discomfort 12.07 10.70 175 416052 17792 63055003
Alanine aminotransferase abnormal 12.07 10.70 60 416167 4444 63068351
Gastrointestinal haemorrhage 12.07 10.70 423 415804 80753 62992042
Infusion site bruising 12.05 10.70 5 416222 3827 63068968
Implant site reaction 12.02 10.70 9 416218 139 63072656
Product availability issue 11.99 10.70 6 416221 4115 63068680
Blood prolactin increased 11.98 10.70 4 416223 3499 63069296
Metabolic disorder 11.97 10.70 15 416212 6488 63066307
Uterine polyp 11.94 10.70 35 416192 2015 63070780
Hypotonia 11.92 10.70 27 416200 9258 63063537
Wound infection 11.90 10.70 202 416025 21208 63051587
Swelling of eyelid 11.90 10.70 3 416224 3153 63069642
Arthrofibrosis 11.88 10.70 5 416222 22 63072773
Osteochondroma 11.79 10.70 4 416223 8 63072787
Bradykinesia 11.77 10.70 10 416217 5178 63067617
Urinary retention postoperative 11.75 10.70 7 416220 72 63072723
Breast cyst excision 11.75 10.70 7 416220 72 63072723
Sexual dysfunction 11.73 10.70 7 416220 4352 63068443
Gastric ulcer 11.67 10.70 222 416005 23815 63048980
C-reactive protein 11.67 10.70 63 416164 4819 63067976
Laryngeal neoplasm 11.66 10.70 6 416221 45 63072750
Serum ferritin increased 11.65 10.70 14 416213 6168 63066627
White blood cells urine positive 11.63 10.70 10 416217 5148 63067647
Antipsychotic drug level increased 11.61 10.70 4 416223 3431 63069364
Clostridium difficile colitis 11.57 10.70 83 416144 20486 63052309
Enteritis 11.56 10.70 23 416204 8263 63064532
Anaemia vitamin B12 deficiency 11.55 10.70 14 416213 405 63072390
Autoimmune hepatitis 11.55 10.70 24 416203 8486 63064309
Cubital tunnel syndrome 11.54 10.70 12 416215 292 63072503
Gingival operation 11.52 10.70 8 416219 109 63072686
Calculus urinary 11.52 10.70 27 416200 1357 63071438
Supraventricular extrasystoles 11.51 10.70 60 416167 4529 63068266
Salivary gland adenoma 11.48 10.70 4 416223 9 63072786
Mineral metabolism disorder 11.48 10.70 4 416223 9 63072786
Calciphylaxis 11.43 10.70 3 416224 3069 63069726
Pulse absent 11.43 10.70 11 416216 5363 63067432
Oral pain 11.41 10.70 255 415972 28139 63044656
Systemic inflammatory response syndrome 11.39 10.70 12 416215 5609 63067186
Uveitis 11.39 10.70 43 416184 12510 63060285
Therapy partial responder 11.38 10.70 34 416193 10624 63062171
Protein urine present 11.38 10.70 14 416213 6106 63066689
Pericoronitis 11.38 10.70 5 416222 25 63072770
Lip neoplasm malignant stage unspecified 11.38 10.70 5 416222 25 63072770
Escherichia infection 11.37 10.70 44 416183 12710 63060085
Blood creatinine abnormal 11.34 10.70 3 416224 3053 63069742
Hepatic pain 11.34 10.70 3 416224 3053 63069742
Small intestinal obstruction 11.31 10.70 72 416155 18265 63054530
Cutis laxa 11.30 10.70 9 416218 153 63072642
Pollakiuria 11.26 10.70 251 415976 27686 63045109
Partial seizures 11.25 10.70 13 416214 5829 63066966
Drug level above therapeutic 11.23 10.70 9 416218 4796 63067999
Euglycaemic diabetic ketoacidosis 11.23 10.70 5 416222 3669 63069126
Post procedural drainage 11.22 10.70 5 416222 26 63072769
Electroencephalogram abnormal 11.22 10.70 5 416222 3667 63069128
Ageusia 11.21 10.70 49 416178 13679 63059116
Procedural pain 11.20 10.70 89 416138 21480 63051315
Papilloedema 11.17 10.70 6 416221 3954 63068841
Breast necrosis 11.15 10.70 9 416218 156 63072639
Spider vein 11.15 10.70 12 416215 304 63072491
Oesophagitis haemorrhagic 11.14 10.70 15 416212 483 63072312
Papilloma 11.11 10.70 11 416216 252 63072543
Metastases to lymph nodes 11.08 10.70 23 416204 8135 63064660
Blindness 11.06 10.70 90 416137 21609 63051186
Immunosuppression 11.02 10.70 26 416201 8788 63064007
Pneumothorax 11.00 10.70 62 416165 16199 63056596
Neurological symptom 11.00 10.70 13 416214 5770 63067025
Sluggishness 10.96 10.70 11 416216 5258 63067537
Lymphocyte percentage decreased 10.94 10.70 3 416224 2982 63069813
Rectocele repair 10.93 10.70 6 416221 52 63072743
Borderline glaucoma 10.92 10.70 4 416223 11 63072784
Uterine stenosis 10.92 10.70 4 416223 11 63072784
Pharyngo-oesophageal diverticulum 10.92 10.70 4 416223 11 63072784
Gingival atrophy 10.92 10.70 5 416222 28 63072767
Injection site vesicles 10.90 10.70 3 416224 2974 63069821
Feeling cold 10.88 10.70 102 416125 23786 63049009
Gastroenteritis viral 10.88 10.70 101 416126 23599 63049196
Wound dehiscence 10.87 10.70 62 416165 4841 63067954
Vertebrobasilar insufficiency 10.87 10.70 9 416218 162 63072633
Product physical issue 10.82 10.70 10 416217 4970 63067825
Blood cholesterol 10.81 10.70 18 416209 702 63072093
Blood pressure systolic decreased 10.78 10.70 20 416207 7377 63065418
Influenza B virus test positive 10.76 10.70 11 416216 262 63072533
Forced expiratory volume decreased 10.76 10.70 10 416217 4958 63067837
Sputum culture 10.73 10.70 11 416216 263 63072532
Fear 10.73 10.70 60 416167 15706 63057089
Open angle glaucoma 10.73 10.70 11 416216 263 63072532
Hypernatraemia 10.72 10.70 21 416206 7588 63065207

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis 399.20 11.31 237 40750 14653 34901291
Osteonecrosis of jaw 339.91 11.31 229 40758 17660 34898284
Femur fracture 270.51 11.31 149 40838 7975 34907969
Atypical femur fracture 188.06 11.31 49 40938 285 34915659
Low turnover osteopathy 175.32 11.31 37 40950 65 34915879
Osteomyelitis 130.07 11.31 125 40862 16011 34899933
Osteoporosis 125.21 11.31 110 40877 12558 34903386
Toxicity to various agents 124.57 11.31 40 40947 200322 34715622
Impaired healing 124.00 11.31 119 40868 15215 34900729
Intramedullary rod insertion 111.92 11.31 21 40966 11 34915933
Bone density decreased 110.19 11.31 51 40936 1878 34914066
Dental caries 105.54 11.31 66 40921 4473 34911471
Open reduction of fracture 102.00 11.31 24 40963 84 34915860
Completed suicide 97.82 11.31 4 40983 98164 34817780
Atypical fracture 97.76 11.31 24 40963 105 34915839
Rheumatoid arthritis 93.70 11.31 164 40823 38074 34877870
Drug abuse 92.56 11.31 6 40981 99090 34816854
Febrile neutropenia 83.79 11.31 28 40959 136821 34779123
Stress fracture 83.60 11.31 34 40953 909 34915035
Tooth disorder 70.65 11.31 75 40912 10807 34905137
Alanine aminotransferase abnormal 70.37 11.31 52 40935 4636 34911308
Blood parathyroid hormone decreased 68.90 11.31 34 40953 1446 34914498
Osteoarthritis 64.73 11.31 99 40888 20543 34895401
Death 63.14 11.31 247 40740 397802 34518142
Periodontal disease 60.95 11.31 26 40961 786 34915158
Hypophosphataemic osteomalacia 57.78 11.31 16 40971 121 34915823
Gastrooesophageal reflux disease 56.19 11.31 132 40855 37792 34878152
Tibia fracture 55.94 11.31 30 40957 1520 34914424
Osteopenia 55.88 11.31 46 40941 4803 34911141
Neutropenia 55.72 11.31 61 40926 156717 34759227
Arthralgia 54.22 11.31 363 40624 169678 34746266
Tooth loss 53.92 11.31 41 40946 3817 34912127
Tooth fracture 53.36 11.31 40 40947 3645 34912299
Exostosis of jaw 53.21 11.31 14 40973 85 34915859
Exposed bone in jaw 52.53 11.31 29 40958 1557 34914387
Asthma 52.17 11.31 138 40849 42518 34873426
Red blood cell sedimentation rate 51.49 11.31 26 40961 1162 34914782
Granuloma skin 49.68 11.31 26 40961 1253 34914691
Arthropathy 49.30 11.31 102 40885 26805 34889139
Jaw disorder 48.99 11.31 31 40956 2144 34913800
Hypercalciuria 48.95 11.31 17 40970 289 34915655
Craniotabes 47.78 11.31 9 40978 5 34915939
Drug ineffective 47.76 11.31 327 40660 456424 34459520
Joint ankylosis 47.33 11.31 27 40960 1545 34914399
Bone fissure 46.21 11.31 10 40977 21 34915923
Synovitis 44.85 11.31 68 40919 13998 34901946
C-reactive protein abnormal 44.51 11.31 53 40934 8657 34907287
Bone cyst 44.24 11.31 26 40961 1574 34914370
Thrombocytopenia 44.11 11.31 72 40915 156175 34759769
Fracture nonunion 43.84 11.31 14 40973 181 34915763
Sleep apnoea syndrome 43.21 11.31 82 40905 20239 34895705
Spinal compression fracture 42.61 11.31 47 40940 7069 34908875
Jaw fracture 42.51 11.31 22 40965 1036 34914908
Blood immunoglobulin E increased 42.22 11.31 30 40957 2516 34913428
Osteonecrosis of external auditory canal 42.07 11.31 10 40977 37 34915907
Anaemia postoperative 40.70 11.31 17 40970 487 34915457
Spinal fracture 40.60 11.31 47 40940 7451 34908493
Rheumatoid nodule 40.48 11.31 31 40956 2916 34913028
Internal fixation of fracture 39.63 11.31 11 40976 84 34915860
Fall 39.49 11.31 387 40600 202498 34713446
Panniculitis 38.97 11.31 26 40961 1968 34913976
Anti-cyclic citrullinated peptide antibody positive 38.38 11.31 25 40962 1818 34914126
Pulmonary vasculitis 37.88 11.31 17 40970 582 34915362
Pulmonary fibrosis 37.60 11.31 73 40914 18323 34897621
Cataract 37.54 11.31 90 40897 26096 34889848
Disease progression 37.33 11.31 43 40944 108034 34807910
Respiratory symptom 36.50 11.31 24 40963 1773 34914171
Intervertebral disc degeneration 36.05 11.31 41 40946 6376 34909568
Pyrexia 35.93 11.31 236 40751 332777 34583167
Pain 35.81 11.31 382 40605 204293 34711651
Skin injury 35.17 11.31 26 40961 2319 34913625
Obstructive airways disorder 34.79 11.31 64 40923 15430 34900514
Hypotension 34.71 11.31 138 40849 221511 34694433
Osteolysis 34.48 11.31 29 40958 3119 34912825
Vomiting 34.02 11.31 162 40825 247459 34668485
Tooth abscess 33.91 11.31 38 40949 5815 34910129
Dental fistula 33.73 11.31 10 40977 99 34915845
Oral infection 33.29 11.31 24 40963 2059 34913885
Exostosis 33.25 11.31 34 40953 4689 34911255
Tendonitis 33.22 11.31 47 40940 9093 34906851
Pain in jaw 32.01 11.31 56 40931 12984 34902960
Infusion related reaction 31.87 11.31 135 40852 52922 34863022
Hypophosphatasia 31.71 11.31 8 40979 40 34915904
Medical device removal 31.62 11.31 10 40977 125 34915819
Foot fracture 31.58 11.31 34 40953 4977 34910967
Acute kidney injury 31.45 11.31 219 40768 304769 34611175
Temporomandibular joint syndrome 31.43 11.31 17 40970 876 34915068
Nerve degeneration 31.14 11.31 11 40976 197 34915747
Abscess jaw 31.10 11.31 16 40971 744 34915200
Lumbar vertebral fracture 30.90 11.31 24 40963 2305 34913639
Basal cell carcinoma 30.84 11.31 70 40917 19588 34896356
Resorption bone increased 30.35 11.31 11 40976 213 34915731
Spinal osteoarthritis 30.15 11.31 41 40946 7642 34908302
Hyperlipidaemia 30.12 11.31 58 40929 14471 34901473
Periodontitis 30.08 11.31 22 40965 1930 34914014
Psoriatic arthropathy 29.41 11.31 69 40918 19729 34896215
Device breakage 29.00 11.31 23 40964 2277 34913667
Hip fracture 29.00 11.31 51 40936 11874 34904070
COVID-19 28.83 11.31 29 40958 77521 34838423
Bone disorder 28.80 11.31 36 40951 6179 34909765
Bone erosion 28.44 11.31 29 40958 3986 34911958
Nasal polyps 27.29 11.31 23 40964 2480 34913464
Rib fracture 26.86 11.31 55 40932 14345 34901599
Tongue disorder 26.48 11.31 32 40955 5307 34910637
Leukopenia 26.37 11.31 21 40966 62835 34853109
Skin ulcer 26.27 11.31 71 40916 22145 34893799
Tooth extraction 26.21 11.31 30 40957 4698 34911246
Alveolar osteitis 25.75 11.31 8 40979 94 34915850
Bone metabolism disorder 25.67 11.31 10 40977 238 34915706
Periprosthetic fracture 25.65 11.31 9 40978 158 34915786
Thoracic vertebral fracture 25.54 11.31 19 40968 1711 34914233
Polymyalgia rheumatica 25.52 11.31 18 40969 1492 34914452
Benign prostatic hyperplasia 25.44 11.31 54 40933 14441 34901503
Fibula fracture 25.42 11.31 15 40972 915 34915029
Neuritis 25.36 11.31 15 40972 919 34915025
Tenosynovitis 25.34 11.31 29 40958 4541 34911403
Coma 25.17 11.31 11 40976 45667 34870277
Off label use 25.14 11.31 344 40643 419180 34496764
Central nervous system mass 25.04 11.31 9 40978 170 34915774
Wall motion score index abnormal 24.89 11.31 9 40978 173 34915771
Renal mass 24.83 11.31 19 40968 1785 34914159
Hand deformity 24.75 11.31 26 40961 3699 34912245
Pathological fracture 24.57 11.31 28 40959 4363 34911581
Dental necrosis 24.49 11.31 6 40981 26 34915918
Nausea 24.40 11.31 268 40719 339640 34576304
Musculoskeletal disorder 24.18 11.31 33 40954 6171 34909773
Suicide attempt 23.91 11.31 8 40979 39108 34876836
Acetabulum fracture 23.89 11.31 10 40977 288 34915656
Red blood cell sedimentation rate abnormal 23.76 11.31 25 40962 3564 34912380
Diverticulitis 23.72 11.31 64 40923 19940 34896004
Rhabdomyolysis 23.66 11.31 27 40960 68136 34847808
Gingival disorder 23.46 11.31 17 40970 1470 34914474
Lactic acidosis 23.29 11.31 6 40981 34766 34881178
Cardiac septal defect 23.24 11.31 10 40977 309 34915635
Eosinophilic granulomatosis with polyangiitis 23.21 11.31 19 40968 1968 34913976
Oesophageal ulcer 23.19 11.31 24 40963 3357 34912587
Fracture 23.11 11.31 34 40953 6815 34909129
Ulcer 23.07 11.31 39 40948 8796 34907148
Rheumatoid lung 22.66 11.31 14 40973 928 34915016
Ankle fracture 22.57 11.31 26 40961 4099 34911845
Airway remodelling 22.51 11.31 9 40978 230 34915714
Cardiac arrest 22.14 11.31 50 40937 96109 34819835
Intentional product misuse 22.11 11.31 13 40974 45598 34870346
Atopy 22.04 11.31 9 40978 243 34915701
Right atrial hypertrophy 22.04 11.31 13 40974 792 34915152
Hepatic fibrosis 21.85 11.31 27 40960 4580 34911364
Enthesopathy 21.83 11.31 27 40960 4586 34911358
Nocturia 21.46 11.31 41 40946 10169 34905775
Scoliosis 21.30 11.31 21 40966 2772 34913172
Bursitis 21.23 11.31 29 40958 5429 34910515
Fracture delayed union 21.16 11.31 6 40981 50 34915894
Gastritis 21.12 11.31 65 40922 21808 34894136
Chronic sinusitis 20.95 11.31 19 40968 2260 34913684
Lumbar spinal stenosis 20.79 11.31 20 40967 2562 34913382
Mobility decreased 20.74 11.31 80 40907 30048 34885896
Nasal septum deviation 20.69 11.31 14 40973 1085 34914859
Bone loss 20.37 11.31 11 40976 565 34915379
Gingivitis 20.35 11.31 23 40964 3552 34912392
Chronic obstructive pulmonary disease 20.35 11.31 112 40875 48806 34867138
Femoral neck fracture 20.07 11.31 22 40965 3285 34912659
Pneumonectomy 19.92 11.31 6 40981 63 34915881
Therapeutic product effect decreased 19.78 11.31 87 40900 34656 34881288
Renal cyst 19.71 11.31 37 40950 9056 34906888
Skin necrosis 19.66 11.31 29 40958 5824 34910120
Blood pressure diastolic abnormal 19.35 11.31 26 40961 4792 34911152
Sequestrectomy 19.22 11.31 8 40979 227 34915717
Kyphosis 19.20 11.31 14 40973 1222 34914722
Clumsiness 19.06 11.31 16 40971 1716 34914228
Bronchiectasis 18.95 11.31 38 40949 9763 34906181
Bronchial secretion retention 18.60 11.31 15 40972 1521 34914423
Oral cavity fistula 18.52 11.31 7 40980 153 34915791
Pelvic cyst 18.39 11.31 5 40982 35 34915909
Hypercholesterolaemia 18.18 11.31 35 40952 8727 34907217
C-reactive protein increased 18.10 11.31 117 40870 53981 34861963
Eosinophilic myocarditis 18.03 11.31 10 40977 542 34915402
Rhinitis 17.92 11.31 29 40958 6309 34909635
Hiatus hernia 17.69 11.31 32 40955 7613 34908331
Microangiopathy 17.59 11.31 12 40975 942 34915002
Blood pressure systolic increased 17.51 11.31 63 40924 22889 34893055
Corneal abrasion 17.50 11.31 8 40979 286 34915658
Cytokine release syndrome 17.26 11.31 3 40984 22874 34893070
Herpes zoster 17.25 11.31 83 40904 34316 34881628
Dental prosthesis placement 17.25 11.31 3 40984 0 34915944
Poor dental condition 17.22 11.31 7 40980 187 34915757
Back pain 17.10 11.31 218 40769 121571 34794373
Bone abscess 17.08 11.31 7 40980 191 34915753
Gastrointestinal infection 17.04 11.31 27 40960 5771 34910173
Foetal exposure during pregnancy 16.91 11.31 12 40975 38089 34877855
Extraskeletal ossification 16.82 11.31 5 40982 50 34915894
Device failure 16.54 11.31 17 40970 2359 34913585
White blood cell count decreased 16.49 11.31 57 40930 95388 34820556
Renal neoplasm 16.42 11.31 13 40974 1284 34914660
Calcium deficiency 16.33 11.31 7 40980 214 34915730
Compression fracture 16.30 11.31 19 40968 3033 34912911
Oesophagitis 16.30 11.31 43 40944 13218 34902726
Cardiac ablation 16.17 11.31 12 40975 1076 34914868
Mouth swelling 16.14 11.31 15 40972 1841 34914103
Osteitis 15.99 11.31 14 40973 1590 34914354
Joint injury 15.90 11.31 34 40953 9139 34906805
Bronchial wall thickening 15.81 11.31 13 40974 1355 34914589
Body temperature decreased 15.75 11.31 42 40945 12992 34902952
Blood pressure fluctuation 15.74 11.31 65 40922 25184 34890760
Oral disorder 15.66 11.31 22 40965 4227 34911717
Osteomalacia 15.66 11.31 11 40976 906 34915038
Idiopathic pulmonary fibrosis 15.63 11.31 20 40967 3514 34912430
Pelvic fracture 15.45 11.31 17 40970 2550 34913394
Loose tooth 15.39 11.31 12 40975 1159 34914785
Carpal tunnel syndrome 15.28 11.31 23 40964 4703 34911241
Arthritis 15.27 11.31 75 40912 31271 34884673
Bone infarction 15.22 11.31 7 40980 254 34915690
Joint dislocation 15.11 11.31 20 40967 3633 34912311
Restrictive pulmonary disease 15.09 11.31 12 40975 1192 34914752
Liver function test abnormal 14.89 11.31 74 40913 31000 34884944
Red blood cell sedimentation rate increased 14.79 11.31 33 40954 9129 34906815
Aortic valve stenosis 14.73 11.31 17 40970 2686 34913258
Dermal sinus 14.71 11.31 3 40984 4 34915940
Overdose 14.66 11.31 56 40931 91003 34824941
Diarrhoea 14.64 11.31 347 40640 389565 34526379
Vertebroplasty 14.59 11.31 4 40983 29 34915915
Right ventricular hypertrophy 14.51 11.31 13 40974 1521 34914423
Drug interaction 14.30 11.31 183 40804 225763 34690181
Penile erythema 14.11 11.31 6 40981 180 34915764
Joint swelling 14.02 11.31 119 40868 59771 34856173
Groin pain 13.95 11.31 24 40963 5489 34910455
Small cell lung cancer 13.93 11.31 14 40973 1891 34914053
Myelomalacia 13.93 11.31 5 40982 94 34915850
Abdominal rigidity 13.84 11.31 12 40975 1345 34914599
Granuloma 13.76 11.31 18 40969 3233 34912711
Sinus polyp 13.69 11.31 6 40981 194 34915750
Chest X-ray abnormal 13.65 11.31 21 40966 4377 34911567
Acute on chronic liver failure 13.64 11.31 5 40982 100 34915844
Ventricular fibrillation 13.50 11.31 5 40982 22949 34892995
Erythrasma 13.46 11.31 4 40983 40 34915904
Embolic stroke 13.45 11.31 21 40966 4433 34911511
Fracture displacement 13.33 11.31 5 40982 107 34915837
Renal failure 13.28 11.31 94 40893 130463 34785481
Loose body in joint 13.19 11.31 4 40983 43 34915901
Limb asymmetry 13.16 11.31 5 40982 111 34915833
Respiratory rate increased 13.11 11.31 33 40954 9861 34906083
Enterocolitis bacterial 13.08 11.31 7 40980 353 34915591
Rhinitis allergic 13.08 11.31 17 40970 3033 34912911
Eosinophilic bronchitis 13.04 11.31 6 40981 218 34915726
Malignant neoplasm progression 13.01 11.31 56 40931 87990 34827954
Intervertebral disc protrusion 12.97 11.31 33 40954 9923 34906021
Animal scratch 12.86 11.31 6 40981 225 34915719
Cellulitis 12.81 11.31 106 40881 52845 34863099
JC virus CSF test positive 12.80 11.31 5 40982 120 34915824
Lung neoplasm 12.77 11.31 21 40966 4630 34911314
Langerhans' cell histiocytosis 12.72 11.31 4 40983 49 34915895
Urinary tract discomfort 12.68 11.31 5 40982 123 34915821
Bladder pain 12.62 11.31 8 40979 555 34915389
Drug ineffective for unapproved indication 12.61 11.31 6 40981 23709 34892235
Bronchoalveolar lavage 12.58 11.31 4 40983 51 34915893
Fracture malunion 12.44 11.31 3 40984 12 34915932
Oral pustule 12.38 11.31 6 40981 245 34915699
Bronchitis 12.38 11.31 88 40899 41875 34874069
Laryngeal ulceration 12.35 11.31 5 40982 132 34915812
Cardiogenic shock 12.33 11.31 8 40979 26610 34889334
Neurotoxicity 12.27 11.31 3 40984 18007 34897937
Iron deficiency anaemia 12.20 11.31 33 40954 10296 34905648
Lenticular opacities 12.16 11.31 6 40981 255 34915689
Mycobacterium chelonae infection 12.14 11.31 9 40978 806 34915138
Dental plaque 12.06 11.31 3 40984 14 34915930
Nasopharyngitis 11.91 11.31 130 40857 69838 34846106
Pulmonary function test abnormal 11.91 11.31 15 40972 2595 34913349
Phlebosclerosis 11.85 11.31 5 40982 147 34915797
Lower limb fracture 11.82 11.31 19 40968 4112 34911832
Cardiac failure 11.74 11.31 61 40926 91187 34824757
Amino acid level increased 11.74 11.31 7 40980 435 34915509
Actinic keratosis 11.71 11.31 20 40967 4547 34911397
Rectal haemorrhage 11.64 11.31 84 40903 40165 34875779
Infection 11.61 11.31 160 40827 90755 34825189
Wound complication 11.51 11.31 14 40973 2336 34913608
Eosinophilic pneumonia chronic 11.47 11.31 6 40981 289 34915655
Ear pain 11.44 11.31 22 40965 5480 34910464
Obstruction 11.42 11.31 15 40972 2704 34913240
Rash maculo-papular 11.32 11.31 10 40977 28441 34887503

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Femur fracture 3837.20 10.43 2222 320524 36430 79385212
Osteonecrosis of jaw 2895.30 10.43 1935 320811 41291 79380351
Osteonecrosis 2503.68 10.43 1563 321183 29532 79392110
Pemphigus 1744.19 10.43 2082 320664 97500 79324142
Atypical femur fracture 1616.42 10.43 654 322092 4535 79417107
Systemic lupus erythematosus 1580.86 10.43 2189 320557 118960 79302682
Glossodynia 1536.18 10.43 1990 320756 101347 79320295
Hand deformity 1493.17 10.43 1968 320778 101951 79319691
Arthropathy 1381.39 10.43 2529 320217 174582 79247060
Low turnover osteopathy 1341.50 10.43 443 322303 1543 79420099
Impaired healing 1248.18 10.43 1653 321093 86002 79335640
Anti-cyclic citrullinated peptide antibody positive 1183.94 10.43 1568 321178 81575 79340067
Pericarditis 1147.21 10.43 1738 321008 102498 79319144
Stress fracture 1138.22 10.43 546 322200 5934 79415708
Wound 1116.26 10.43 1820 320926 114359 79307283
Osteomyelitis 1107.29 10.43 978 321768 31887 79389755
Toxicity to various agents 1091.69 10.43 195 322551 421345 79000297
Dental caries 1039.85 10.43 629 322117 11191 79410451
Synovitis 973.49 10.43 1988 320758 148746 79272896
Abdominal discomfort 939.85 10.43 2678 320068 248049 79173593
Duodenal ulcer perforation 898.56 10.43 1220 321526 64991 79356651
Alopecia 898.25 10.43 2503 320243 228852 79192790
Helicobacter infection 841.14 10.43 1214 321532 68490 79353152
Tooth disorder 828.95 10.43 753 321993 25480 79396162
Death 828.93 10.43 649 322097 565865 78855777
Discomfort 820.68 10.43 1665 321081 123952 79297690
Completed suicide 808.69 10.43 46 322700 245721 79175921
Jaw disorder 783.89 10.43 390 322356 4616 79417026
Swelling 748.76 10.43 2249 320497 214462 79207180
Osteoarthritis 718.35 10.43 1277 321469 86032 79335610
Acute kidney injury 694.87 10.43 648 322098 518756 78902886
Oral infection 685.13 10.43 372 322374 5335 79416307
Contraindicated product administered 655.42 10.43 1749 320997 155789 79265853
Drug intolerance 632.43 10.43 2424 320322 261695 79159947
Infusion related reaction 629.46 10.43 2206 320540 228031 79193611
Rheumatoid factor positive 605.13 10.43 960 321786 58879 79362763
Febrile neutropenia 603.59 10.43 104 322642 230895 79190747
Fracture nonunion 587.20 10.43 224 322522 1298 79420344
Neutropenia 584.25 10.43 217 322529 287493 79134149
Irritable bowel syndrome 581.07 10.43 963 321783 61278 79360364
Hepatic enzyme increased 576.53 10.43 1837 320909 180773 79240869
Therapeutic product effect decreased 569.83 10.43 1705 321041 162158 79259484
Drug abuse 555.59 10.43 24 322722 162667 79258975
Muscle injury 535.64 10.43 811 321935 47750 79373892
Exostosis of jaw 521.61 10.43 195 322551 1059 79420583
Folliculitis 503.78 10.43 847 321899 54533 79367109
Tooth fracture 495.53 10.43 395 322351 11135 79410507
Hypersensitivity 492.15 10.43 2234 320512 260005 79161637
Hypotension 485.63 10.43 643 322103 439674 78981968
Temporomandibular joint syndrome 481.20 10.43 259 322487 3646 79417996
Bone disorder 481.11 10.43 484 322262 18629 79403013
Off label use 477.80 10.43 1973 320773 905242 78516400
Drug interaction 470.50 10.43 594 322152 414589 79007053
Blister 464.30 10.43 1294 321452 118182 79303460
Adverse event 436.30 10.43 834 321912 59380 79362262
Blood cholesterol increased 429.37 10.43 1007 321739 82713 79338929
Sleep disorder due to general medical condition, insomnia type 426.90 10.43 689 322057 42867 79378775
Thrombocytopenia 426.39 10.43 274 322472 264985 79156657
Joint swelling 426.25 10.43 2297 320449 286349 79135293
Maternal exposure during pregnancy 411.23 10.43 1352 321394 135186 79286456
Gingival disorder 410.73 10.43 228 322518 3423 79418219
Exostosis 399.05 10.43 413 322333 16445 79405197
Hyperlipidaemia 391.10 10.43 505 322241 25588 79396054
Periodontal disease 382.25 10.43 175 322571 1695 79419947
Bone density decreased 373.21 10.43 358 322388 12989 79408653
Disease progression 369.13 10.43 142 322604 184220 79237422
Intentional overdose 367.21 10.43 14 322732 105946 79315696
Pathological fracture 353.65 10.43 313 322433 10224 79411418
Anaemia postoperative 350.80 10.43 165 322581 1709 79419933
Tooth loss 346.72 10.43 262 322484 6813 79414829
Cardiac arrest 333.98 10.43 139 322607 171957 79249685
Blood parathyroid hormone decreased 333.90 10.43 303 322443 10233 79411409
Bursitis 332.32 10.43 553 322193 35291 79386351
COVID-19 329.95 10.43 113 322633 157561 79264081
Vomiting 323.56 10.43 1491 321255 664337 78757305
Nausea 322.95 10.43 2411 320335 954785 78466857
Rheumatic fever 322.49 10.43 482 322264 28043 79393599
Intervertebral disc degeneration 317.85 10.43 355 322391 15430 79406212
Arthralgia 314.22 10.43 3615 319131 568188 78853454
Bone loss 310.00 10.43 168 322578 2399 79419243
Gastrooesophageal reflux disease 304.66 10.43 1022 321724 103224 79318418
Granuloma skin 302.90 10.43 270 322476 8904 79412738
Fracture delayed union 302.87 10.43 155 322591 1955 79419687
Spinal osteoarthritis 300.97 10.43 357 322389 16570 79405072
Jaw fracture 295.22 10.43 172 322574 2845 79418797
Rheumatoid nodule 294.04 10.43 358 322388 17080 79404562
Diarrhoea 293.38 10.43 2225 320521 878264 78543378
Hip arthroplasty 291.33 10.43 521 322225 35235 79386407
Product dose omission issue 288.66 10.43 346 322400 247191 79174451
Resorption bone increased 285.78 10.43 133 322613 1342 79420300
Panniculitis 278.37 10.43 295 322451 12076 79409566
Adverse drug reaction 273.64 10.43 735 322011 65657 79355985
Loose tooth 269.30 10.43 164 322582 2953 79418689
Foot fracture 268.13 10.43 385 322361 21596 79400046
Tooth abscess 262.36 10.43 326 322420 15884 79405758
Atypical fracture 261.96 10.43 101 322645 605 79421037
Swollen joint count increased 261.45 10.43 389 322357 22538 79399104
Malignant neoplasm progression 260.37 10.43 112 322634 135878 79285764
Hypercholesterolaemia 252.19 10.43 384 322362 22711 79398931
Oral disorder 251.05 10.43 254 322492 9841 79411801
Sepsis 248.15 10.43 444 322302 268984 79152658
Suicide attempt 240.75 10.43 27 322719 82905 79338737
Knee arthroplasty 240.22 10.43 537 322209 42711 79378931
Spondylolisthesis 238.88 10.43 153 322593 3022 79418620
Fibromyalgia 235.31 10.43 682 322064 63658 79357984
Cardio-respiratory arrest 233.59 10.43 74 322672 108436 79313206
Periodontitis 228.11 10.43 170 322576 4326 79417316
Gastrointestinal disorder 228.02 10.43 1040 321706 121165 79300477
Gingivitis 226.21 10.43 228 322518 8793 79412849
Platelet count decreased 224.87 10.43 274 322472 194390 79227252
Diverticulum 224.32 10.43 289 322457 14607 79407035
Oral cavity fistula 223.24 10.43 90 322656 617 79421025
Osteopenia 223.04 10.43 321 322425 18043 79403599
Pyrexia 222.86 10.43 1721 321025 676988 78744654
Edentulous 222.02 10.43 69 322677 186 79421456
Hip fracture 219.00 10.43 423 322323 30338 79391304
Device failure 208.16 10.43 185 322561 6076 79415566
Ulcer 207.11 10.43 407 322339 29565 79392077
Basal cell carcinoma 206.37 10.43 463 322283 36912 79384730
Type 2 diabetes mellitus 205.53 10.43 602 322144 56520 79365122
Multiple organ dysfunction syndrome 203.11 10.43 117 322629 120129 79301513
Uterine disorder 200.69 10.43 120 322626 2087 79419555
Intentional product misuse 199.39 10.43 68 322678 95097 79326545
White blood cell count decreased 198.09 10.43 284 322462 188004 79233638
Contusion 196.69 10.43 1150 321596 147626 79274016
Anaemia 194.18 10.43 1034 321712 443981 78977661
Lower respiratory tract infection 193.52 10.43 1033 321713 128187 79293455
Pain 192.75 10.43 3953 318793 699849 78721793
Osteoporosis 192.51 10.43 568 322178 53544 79368098
Stomatitis 191.82 10.43 1131 321615 145626 79276016
Exposed bone in jaw 191.74 10.43 142 322604 3578 79418064
Ulna fracture 190.57 10.43 93 322653 1052 79420590
Seizure 188.78 10.43 295 322451 188539 79233103
Treatment failure 187.44 10.43 1257 321489 169229 79252413
Product use issue 185.87 10.43 1469 321277 208353 79213289
Lactic acidosis 185.11 10.43 31 322715 70328 79351314
Ill-defined disorder 182.89 10.43 635 322111 65240 79356402
Renal failure 182.45 10.43 334 322412 200634 79221008
Hyperhidrosis 181.61 10.43 207 322539 151285 79270357
Psoriatic arthropathy 179.78 10.43 708 322038 77291 79344351
Tonsillar disorder 178.82 10.43 92 322654 1174 79420468
Skin necrosis 178.39 10.43 287 322459 17800 79403842
Abscess jaw 174.66 10.43 101 322645 1646 79419996
Pancytopenia 173.34 10.43 251 322495 165494 79256148
Drug tolerance decreased 172.68 10.43 237 322509 12741 79408901
Scoliosis 171.51 10.43 180 322566 7284 79414358
Fibrocystic breast disease 170.10 10.43 73 322673 597 79421045
Fracture displacement 169.02 10.43 90 322656 1238 79420404
Vitamin D deficiency 168.18 10.43 246 322500 14033 79407609
Asthenia 167.94 10.43 1297 321449 510392 78911250
Respiratory failure 167.50 10.43 297 322449 180614 79241028
Osteitis 167.11 10.43 134 322612 3809 79417833
Infection 167.02 10.43 1602 321144 240110 79181532
Rib fracture 166.53 10.43 357 322389 27590 79394052
Overdose 163.79 10.43 310 322436 183896 79237746
Tibia fracture 163.68 10.43 151 322595 5210 79416432
Rotator cuff syndrome 163.36 10.43 241 322505 13854 79407788
Spinal compression fracture 163.05 10.43 266 322480 16692 79404950
Pneumonia 162.97 10.43 1798 320948 658448 78763194
Cerumen impaction 162.59 10.43 86 322660 1166 79420476
Pelvic fracture 162.58 10.43 223 322523 11981 79409661
Fistula discharge 160.95 10.43 88 322658 1280 79420362
Intramedullary rod insertion 158.99 10.43 50 322696 142 79421500
Leukopenia 158.10 10.43 143 322603 116370 79305272
Cataract 157.26 10.43 581 322165 61539 79360103
Electrocardiogram QT prolonged 156.88 10.43 85 322661 90301 79331341
Neutrophil count decreased 156.43 10.43 93 322653 93866 79327776
Dental fistula 155.24 10.43 64 322682 468 79421174
Musculoskeletal stiffness 153.71 10.43 1223 321523 173785 79247857
Foot deformity 153.30 10.43 316 322430 23758 79397884
Fall 152.60 10.43 2796 319950 484833 78936809
Depressed level of consciousness 148.21 10.43 105 322641 96547 79325095
Tachycardia 147.89 10.43 311 322435 177457 79244185
Tendonitis 147.30 10.43 309 322437 23521 79398121
Pulmonary embolism 145.59 10.43 297 322449 171357 79250285
Breast disorder 143.62 10.43 95 322651 1986 79419656
Respiratory arrest 143.57 10.43 29 322717 57521 79364121
Drug reaction with eosinophilia and systemic symptoms 143.35 10.43 41 322705 64203 79357439
Rhabdomyolysis 141.82 10.43 125 322621 103006 79318636
Pain in jaw 140.58 10.43 459 322287 45692 79375950
Septic shock 140.55 10.43 174 322572 122627 79299015
Metabolic acidosis 139.78 10.43 80 322666 82449 79339193
Alveolar osteitis 138.74 10.43 68 322678 777 79420865
Sedation 138.45 10.43 22 322724 51873 79369769
Sinusitis 138.11 10.43 1302 321444 194199 79227443
Hyperkalaemia 137.44 10.43 156 322590 114242 79307400
Bradycardia 137.14 10.43 210 322536 135347 79286295
Mucosal inflammation 135.73 10.43 68 322678 75512 79346130
Somnolence 135.02 10.43 504 322242 238477 79183165
Hiatus hernia 134.56 10.43 294 322452 23018 79398624
Dental necrosis 134.52 10.43 43 322703 131 79421511
Muscle strain 133.98 10.43 179 322567 9376 79412266
Encephalopathy 133.02 10.43 53 322693 67344 79354298
Periprosthetic fracture 129.45 10.43 59 322687 565 79421077
Dehydration 129.04 10.43 541 322205 247646 79173996
Blood creatinine increased 128.35 10.43 272 322474 154785 79266857
Ascites 128.33 10.43 73 322673 75489 79346153
Lumbar spinal stenosis 127.88 10.43 131 322615 5151 79416491
Injection site pain 127.68 10.43 205 322541 129633 79292009
Stress urinary incontinence 126.74 10.43 84 322662 1762 79419880
Agitation 126.42 10.43 130 322616 99585 79322057
Lower limb fracture 126.38 10.43 286 322460 22929 79398713
Radius fracture 125.88 10.43 109 322637 3455 79418187
Wrist fracture 125.63 10.43 195 322551 11726 79409916
Skin ulcer 125.15 10.43 492 322254 53658 79367984
Hypercalcaemia 125.06 10.43 391 322355 38039 79383603
Large intestine polyp 124.44 10.43 201 322545 12507 79409135
Arthritis 123.19 10.43 842 321904 114038 79307604
Synovial cyst 122.32 10.43 176 322570 9889 79411753
Appendix disorder 122.13 10.43 80 322666 1644 79419998
Kyphosis 121.67 10.43 95 322651 2596 79419046
Loss of consciousness 121.12 10.43 317 322429 167626 79254016
Haemorrhoids 120.51 10.43 323 322423 28805 79392837
Hyperaesthesia teeth 119.53 10.43 81 322665 1765 79419877
Abscess oral 117.71 10.43 74 322672 1413 79420229
Anaphylactic reaction 116.96 10.43 100 322646 83643 79337999
Lumbar radiculopathy 116.01 10.43 82 322664 1917 79419725
Drug ineffective for unapproved indication 115.62 10.43 32 322714 51206 79370436
Spinal fracture 114.98 10.43 237 322509 17817 79403825
Meniscus injury 114.18 10.43 139 322607 6629 79415013
Dyspnoea 113.49 10.43 2624 320122 854401 78567241
Neoplasm progression 113.45 10.43 34 322712 51648 79369994
Drug resistance 112.38 10.43 18 322728 42195 79379447
Sciatica 111.80 10.43 342 322404 32880 79388762
Fibula fracture 111.23 10.43 103 322643 3571 79418071
Abscess 111.03 10.43 270 322476 22681 79398961
Haemoglobin decreased 110.67 10.43 492 322254 221627 79200015
Tremor 110.15 10.43 338 322408 169745 79251897
Hepatic failure 108.52 10.43 56 322690 61156 79360486
Myelosuppression 107.68 10.43 17 322729 40279 79381363
Fistula 107.25 10.43 190 322556 12750 79408892
Flushing 106.42 10.43 120 322626 88148 79333494
Cytokine release syndrome 106.30 10.43 11 322735 35987 79385655
Blood glucose increased 105.26 10.43 190 322556 114785 79306857
Red blood cell sedimentation rate 104.97 10.43 121 322625 5444 79416198
Atrophic vulvovaginitis 100.44 10.43 63 322683 1198 79420444
Sopor 100.35 10.43 9 322737 33001 79388641
Cystocele 99.92 10.43 53 322693 723 79420919
Renal impairment 99.74 10.43 317 322429 157466 79264176
Osteoradionecrosis 99.10 10.43 31 322715 86 79421556
Liver injury 98.33 10.43 472 322274 56142 79365500
Pulmonary oedema 97.91 10.43 128 322618 88126 79333516
Jaw operation 96.63 10.43 53 322693 776 79420866
Wrong technique in product usage process 96.29 10.43 94 322652 73781 79347861
Oesophagitis 96.14 10.43 265 322481 24024 79397618
Joint effusion 95.92 10.43 220 322526 17794 79403848
Gingival bleeding 95.92 10.43 207 322539 16069 79405573
Bone lesion 95.72 10.43 119 322627 5800 79415842
Ligament sprain 95.64 10.43 185 322561 13279 79408363
Hepatocellular injury 94.62 10.43 37 322709 47556 79374086
Tenosynovitis 94.17 10.43 200 322546 15354 79406288
Patellofemoral pain syndrome 93.78 10.43 45 322701 489 79421153
Cognitive disorder 93.45 10.43 87 322659 69839 79351803
Aggression 92.77 10.43 45 322701 50913 79370729
Facet joint syndrome 92.45 10.43 165 322581 11137 79410505
Feeling abnormal 92.34 10.43 332 322414 158867 79262775
Peripheral venous disease 92.23 10.43 201 322545 15708 79405934
Fractured sacrum 92.13 10.43 66 322680 1577 79420065
Peripheral swelling 91.99 10.43 1568 321178 268049 79153593
Bone marrow failure 91.73 10.43 46 322700 51061 79370581
Cardiogenic shock 91.23 10.43 28 322718 41886 79379756
Pulpitis dental 90.76 10.43 60 322686 1253 79420389
Intentional self-injury 90.53 10.43 12 322734 32407 79389235
Cytomegalovirus infection 90.13 10.43 30 322716 42614 79379028
Intervertebral disc protrusion 89.84 10.43 254 322492 23367 79398275
Polymyalgia rheumatica 89.56 10.43 101 322645 4436 79417206
Osteonecrosis of external auditory canal 89.08 10.43 32 322714 152 79421490
Angioedema 88.82 10.43 106 322640 75929 79345713
Inflammation 88.82 10.43 667 322079 93086 79328556
Joint dislocation 88.13 10.43 205 322541 16734 79404908
Road traffic accident 87.72 10.43 380 322366 43284 79378358
Femoral neck fracture 87.17 10.43 150 322596 9834 79411808
Cardiac failure 87.12 10.43 327 322419 154515 79267127
Nasal septum deviation 86.59 10.43 67 322679 1806 79419836
Hypertension 85.59 10.43 1845 320901 329147 79092495
Tooth extraction 85.46 10.43 157 322589 10838 79410804
Abortion spontaneous 84.64 10.43 10 322736 29497 79392145
Neurotoxicity 84.05 10.43 15 322731 32503 79389139
Adjustment disorder with depressed mood 83.95 10.43 140 322606 8946 79412696
Hypoglycaemia 83.40 10.43 179 322567 101415 79320227
Oesophageal ulcer 83.35 10.43 121 322625 6854 79414788
Toothache 83.17 10.43 222 322524 19748 79401894
Deep vein thrombosis postoperative 82.90 10.43 153 322593 10599 79411043
Injury 82.46 10.43 567 322179 76929 79344713
Myocardial infarction 82.27 10.43 424 322322 183705 79237937
Anaphylactic shock 82.12 10.43 22 322724 35974 79385668
Mitral valve prolapse 81.72 10.43 68 322678 2039 79419603
Tenosynovitis stenosans 81.24 10.43 80 322666 2998 79418644
Blood bilirubin increased 80.98 10.43 89 322657 66143 79355499
Toxic epidermal necrolysis 80.20 10.43 40 322706 44541 79377101
Oedema mouth 79.97 10.43 79 322667 2972 79418670
Calcium deficiency 79.46 10.43 48 322698 851 79420791
Disturbance in attention 79.44 10.43 54 322692 50747 79370895
Cholestasis 79.36 10.43 57 322689 52052 79369590
Osteomyelitis chronic 79.29 10.43 44 322702 660 79420982
Suicidal ideation 78.41 10.43 117 322629 76223 79345419
Gingival recession 78.26 10.43 54 322692 1213 79420429
Clostridium difficile infection 77.24 10.43 38 322708 42647 79378995
Compression fracture 77.10 10.43 112 322634 6348 79415294
Actinomycosis 77.02 10.43 51 322695 1068 79420574
Red blood cell sedimentation rate increased 76.18 10.43 378 322368 45564 79376078
Eustachian tube dysfunction 75.85 10.43 33 322713 280 79421362
Rectocele 75.74 10.43 41 322705 584 79421058
Accidental exposure to product 75.63 10.43 17 322729 31305 79390337
Seborrhoeic keratosis 75.03 10.43 68 322678 2292 79419350
Lung neoplasm 75.00 10.43 116 322630 6953 79414689
Carotid bruit 74.93 10.43 44 322702 739 79420903
Epistaxis 74.78 10.43 218 322528 111297 79310345
Limb asymmetry 74.44 10.43 40 322706 561 79421081
Jaw cyst 74.37 10.43 27 322719 133 79421509
Oroantral fistula 74.11 10.43 35 322711 366 79421276
Diabetic ketoacidosis 73.89 10.43 23 322723 34099 79387543
Rash erythematous 73.57 10.43 75 322671 57694 79363948
Pleural effusion 73.38 10.43 320 322426 144942 79276700
Joint range of motion decreased 73.37 10.43 298 322448 32984 79388658
Carpal tunnel syndrome 73.30 10.43 209 322537 19319 79402323
Hospitalisation 73.29 10.43 171 322575 94065 79327577
Unevaluable event 73.28 10.43 70 322676 55515 79366127
Colitis 72.75 10.43 115 322631 73192 79348450
Inappropriate schedule of product administration 72.72 10.43 286 322460 133342 79288300
Bone sequestrum 72.68 10.43 51 322695 1178 79420464
Premature delivery 72.42 10.43 6 322740 23461 79398181
Restlessness 71.93 10.43 50 322696 46442 79375200
Reversible airways obstruction 71.75 10.43 64 322682 2112 79419530
Serotonin syndrome 71.57 10.43 47 322699 44980 79376662
Poisoning 71.42 10.43 9 322737 25263 79396379
Hypoxia 71.30 10.43 199 322547 103044 79318598
Abnormal behaviour 71.28 10.43 29 322717 36392 79385250
COVID-19 pneumonia 70.99 10.43 15 322731 28834 79392808
Injection site erythema 70.87 10.43 130 322616 78067 79343575
Sjogren's syndrome 70.11 10.43 41 322705 683 79420959
Feeling hot 70.06 10.43 83 322663 59651 79361991
Trismus 69.98 10.43 98 322648 5369 79416273
Sinus disorder 69.83 10.43 225 322521 22239 79399403
Weight decreased 69.21 10.43 1016 321730 354182 79067460
Disorientation 68.66 10.43 92 322654 62684 79358958
Pericardial effusion 68.57 10.43 52 322694 46185 79375457
Varicose vein 68.52 10.43 87 322659 4332 79417310
Posterior reversible encephalopathy syndrome 68.20 10.43 12 322734 26269 79395373
Lip dry 67.88 10.43 175 322571 15243 79406399
Dental plaque 67.88 10.43 22 322724 71 79421571
Pallor 67.23 10.43 62 322684 50000 79371642
Abdominal pain 66.96 10.43 1141 321605 388428 79033214
Rash maculo-papular 66.76 10.43 77 322669 56001 79365641
Rhinitis allergic 66.61 10.43 151 322595 12118 79409524
Tumour lysis syndrome 66.51 10.43 9 322737 23930 79397712
Therapy interrupted 66.32 10.43 22 322724 31319 79390323
Hepatotoxicity 66.16 10.43 66 322680 51286 79370356
Tongue disorder 66.10 10.43 163 322583 13812 79407830
Acute respiratory distress syndrome 66.07 10.43 49 322697 44018 79377624
Status epilepticus 65.93 10.43 11 322735 25030 79396612
Prescribed overdose 65.90 10.43 316 322430 37567 79384075
Dislocation of vertebra 65.69 10.43 116 322630 7764 79413878
Acute myocardial infarction 65.52 10.43 133 322613 76903 79344739
Drug tolerance 65.08 10.43 122 322624 8553 79413089
Bone fragmentation 65.04 10.43 38 322708 632 79421010
Anti-cyclic citrullinated peptide antibody 64.87 10.43 98 322648 5754 79415888
Tooth deposit 64.80 10.43 29 322717 265 79421377
Fracture 64.75 10.43 215 322531 21586 79400056
Pneumonitis 64.74 10.43 91 322655 60769 79360873
Generalised tonic-clonic seizure 64.33 10.43 50 322696 43860 79377782
Enthesopathy 64.29 10.43 144 322602 11464 79410178
Cough 64.10 10.43 1071 321675 365718 79055924
Urinary tract discomfort 64.05 10.43 39 322707 702 79420940
Palmar-plantar erythrodysaesthesia syndrome 63.85 10.43 27 322719 33107 79388535
Product use in unapproved indication 63.84 10.43 676 322070 249683 79171959
Skin discolouration 63.66 10.43 44 322702 40990 79380652
Sequestrectomy 63.52 10.43 41 322705 821 79420821
Shock 63.28 10.43 50 322696 43498 79378144
Hepatic cytolysis 63.07 10.43 16 322730 27135 79394507
Vital capacity decreased 63.05 10.43 55 322691 1761 79419881
Vertebral foraminal stenosis 62.66 10.43 46 322700 1143 79420499
Thoracic vertebral fracture 62.58 10.43 91 322655 5162 79416480
Respiratory distress 62.29 10.43 87 322659 58252 79363390
Retinitis 61.84 10.43 94 322652 5549 79416093
Autoimmune disorder 61.59 10.43 177 322569 16435 79405207
Ventricular fibrillation 61.54 10.43 26 322720 31900 79389742
Constipation 61.07 10.43 793 321953 282257 79139385
Neutropenic sepsis 60.88 10.43 17 322729 27047 79394595
Gastritis 60.80 10.43 367 322379 47626 79374016
Neuroleptic malignant syndrome 60.72 10.43 18 322728 27541 79394101
Neuropathy peripheral 60.53 10.43 330 322416 140975 79280667
Haematochezia 60.47 10.43 169 322577 87476 79334166
Haemorrhage 60.45 10.43 179 322567 90939 79330703
Scleritis 60.15 10.43 81 322665 4275 79417367
Hypervolaemia 59.57 10.43 51 322695 42639 79379003
Headache 59.28 10.43 2108 320638 651664 78769978
Respiratory depression 59.16 10.43 19 322727 27611 79394031
Chest discomfort 58.80 10.43 323 322423 137721 79283921
Spinal disorder 58.76 10.43 129 322617 10131 79411511
Pancreatitis 58.66 10.43 118 322628 68457 79353185
Acute sinusitis 58.61 10.43 82 322664 4488 79417154
Blood pressure decreased 58.61 10.43 206 322540 99260 79322382
Purulence 58.50 10.43 57 322689 2108 79419534
Brain oedema 58.47 10.43 15 322731 25248 79396394
Psychotic disorder 58.34 10.43 49 322697 41353 79380289
Depressed mood 58.33 10.43 66 322680 48414 79373228
Mastication disorder 58.05 10.43 63 322683 2650 79418992
Dermal sinus 57.88 10.43 15 322731 14 79421628
Unresponsive to stimuli 57.78 10.43 85 322661 55703 79365939
Eosinophilia 57.59 10.43 59 322687 45286 79376356
Illness 57.41 10.43 62 322684 46449 79375193
Bruxism 57.33 10.43 76 322670 3950 79417692
Psoriasis 57.28 10.43 179 322567 89408 79332234
Dystonia 57.24 10.43 9 322737 21390 79400252
Oesophageal stenosis 57.15 10.43 79 322667 4275 79417367
Kyphoscoliosis 56.95 10.43 26 322720 250 79421392
Rash 56.83 10.43 2873 319873 575485 78846157
Agranulocytosis 56.73 10.43 59 322687 44971 79376671
Acute myeloid leukaemia 56.64 10.43 27 322719 30858 79390784
Transaminases increased 56.41 10.43 76 322670 51667 79369975
Joint injury 56.41 10.43 264 322482 31071 79390571
Spinal stenosis 56.38 10.43 166 322580 15625 79406017
Drug eruption 56.31 10.43 337 322409 43598 79378044
Maternal exposure timing unspecified 55.88 10.43 91 322655 5701 79415941
Injection site swelling 55.80 10.43 65 322681 47067 79374575
Drug level increased 55.78 10.43 47 322699 39604 79382038
Dry skin 55.63 10.43 120 322626 67875 79353767
Blood creatine phosphokinase increased 55.45 10.43 115 322631 65975 79355667
Radiculopathy 55.21 10.43 115 322631 8709 79412933
Internal fixation of fracture 55.14 10.43 28 322718 347 79421295
Bone formation decreased 55.10 10.43 18 322728 60 79421582
Mycotic allergy 54.75 10.43 47 322699 1472 79420170
Bone metabolism disorder 54.60 10.43 31 322715 487 79421155
Postmenopause 54.58 10.43 14 322732 12 79421630
Tooth infection 54.40 10.43 184 322562 18648 79402994
Acetabulum fracture 54.34 10.43 33 322713 591 79421051
Animal scratch 53.93 10.43 46 322700 1428 79420214
Ventricular tachycardia 53.90 10.43 54 322692 41881 79379761
Aphasia 53.67 10.43 66 322680 46666 79374976
Barrett's oesophagus 53.58 10.43 36 322710 773 79420869
Therapy cessation 53.49 10.43 44 322702 37518 79384124
Withdrawal syndrome 53.17 10.43 21 322725 26833 79394809
Breast calcifications 53.09 10.43 37 322709 845 79420797
Irritability 52.87 10.43 53 322693 41091 79380551
Oral fibroma 52.59 10.43 14 322732 16 79421626
Haemophagocytic lymphohistiocytosis 52.43 10.43 12 322734 21825 79399817
Altered state of consciousness 52.35 10.43 60 322686 43762 79377880
Hair follicle tumour benign 51.91 10.43 29 322717 441 79421201
Product prescribing error 51.78 10.43 63 322683 44750 79376892
Renal cyst 51.77 10.43 154 322592 14578 79407064
Lumbar vertebral fracture 51.74 10.43 98 322648 6924 79414718
Bacteraemia 51.18 10.43 35 322711 32789 79388853
Multiple sclerosis relapse 51.08 10.43 68 322678 46465 79375177
Ankle fracture 50.98 10.43 168 322578 16801 79404841
Mobility decreased 50.90 10.43 735 322011 121440 79300202
Synovial fluid analysis 50.86 10.43 55 322691 2304 79419338
Dyskinesia 50.62 10.43 64 322682 44709 79376933
Plasma cell myeloma 50.56 10.43 86 322660 53173 79368469
Mydriasis 50.55 10.43 6 322740 17637 79404005
Thyroid neoplasm 50.19 10.43 63 322683 3101 79418541
Myocarditis 50.11 10.43 13 322733 21720 79399922
Hypothermia 49.85 10.43 15 322731 22731 79398911
Malaise 49.64 10.43 1557 321189 488312 78933330
Iliotibial band syndrome 49.50 10.43 15 322731 36 79421606
Laryngitis 49.27 10.43 160 322586 15879 79405763
Alanine aminotransferase abnormal 49.11 10.43 110 322636 8757 79412885
Open reduction of fracture 48.91 10.43 23 322723 238 79421404
Hallucination 48.91 10.43 180 322566 85565 79336077
Pulmonary fibrosis 48.86 10.43 326 322420 43786 79377856
Hyperbilirubinaemia 48.83 10.43 19 322727 24499 79397143
Lethargy 48.81 10.43 167 322579 81125 79340517
Cardiac murmur 48.74 10.43 158 322588 15666 79405976
Creatinine renal clearance decreased 48.61 10.43 9 322737 18993 79402649
Oxygen saturation decreased 48.58 10.43 314 322432 128733 79292909
Peptic ulcer 48.54 10.43 89 322657 6134 79415508
Myoclonus 48 10.43 26 322720 27634 79394008
Ear pain 47.96 10.43 261 322485 32608 79389034
Postmenopausal haemorrhage 47.93 10.43 44 322702 1508 79420134
Haematotoxicity 47.80 10.43 4 322742 15515 79406127
Dysarthria 47.69 10.43 129 322617 67493 79354149
Nasopharyngitis 47.27 10.43 1354 321392 252527 79169115
Therapy partial responder 47.26 10.43 7 322739 17390 79404252
Live birth 47.16 10.43 175 322571 18569 79403073
Acute hepatic failure 47.10 10.43 32 322714 30081 79391561
Lymphocyte count decreased 47.09 10.43 74 322672 47215 79374427
Skin exfoliation 46.97 10.43 95 322651 55005 79366637
Gingival pain 46.92 10.43 109 322637 8889 79412753
Onychomycosis 46.33 10.43 103 322643 8158 79413484
C-reactive protein abnormal 46.30 10.43 345 322401 48022 79373620
Device issue 46.29 10.43 26 322720 27082 79394560
Skeletal injury 46.01 10.43 41 322705 1351 79420291
Coma 45.93 10.43 230 322516 100419 79321223
Oestrogen deficiency 45.60 10.43 16 322730 70 79421572
Mental status changes 45.54 10.43 130 322616 66829 79354813
Acquired oesophageal web 45.53 10.43 24 322722 323 79421319
Back disorder 45.50 10.43 126 322620 11452 79410190
Drug withdrawal syndrome 45.44 10.43 44 322702 34674 79386968
Patella fracture 45.34 10.43 47 322699 1874 79419768
Hypokalaemia 45.28 10.43 369 322377 143671 79277971
Gingival abscess 44.99 10.43 33 322713 819 79420823
Anaemia of chronic disease 44.85 10.43 55 322691 2643 79418999
Thrombotic microangiopathy 44.75 10.43 13 322733 20156 79401486
Epilepsy 44.56 10.43 60 322686 40800 79380842
Bladder disorder 44.52 10.43 108 322638 9057 79412585
Bronchial secretion retention 44.46 10.43 68 322678 4036 79417606
Device dislocation 44.22 10.43 25 322721 25945 79395697
Depression 43.97 10.43 1169 321577 215621 79206021
Anuria 43.86 10.43 15 322731 20948 79400694
Incorrect dose administered 43.62 10.43 161 322585 76469 79345173
Chills 43.57 10.43 426 322320 159808 79261834
Dupuytren's contracture 43.55 10.43 13 322733 29 79421613
Accidental overdose 43.29 10.43 58 322688 39523 79382119
Stevens-Johnson syndrome 43.23 10.43 57 322689 39109 79382533
Aortic arteriosclerosis 43.23 10.43 105 322641 8813 79412829
Syncope 43.14 10.43 491 322255 178958 79242684
Hyponatraemia 43 10.43 486 322260 177362 79244280
Drug ineffective 42.80 10.43 3781 318965 1077132 78344510
Gamma-glutamyltransferase increased 42.69 10.43 99 322647 54581 79367061
Aplastic anaemia 42.67 10.43 10 322736 17895 79403747
Hepatitis 42.63 10.43 102 322644 55625 79366017
Haematocrit decreased 42.46 10.43 118 322628 61194 79360448
Cervicobrachial syndrome 42.41 10.43 36 322710 1110 79420532
Carotid artery disease 42.32 10.43 49 322697 2215 79419427
Traumatic ulcer 42.12 10.43 14 322732 50 79421592
Oral pain 42.10 10.43 246 322500 31552 79390090
Osteomalacia 41.94 10.43 40 322706 1440 79420202
Pancreatitis acute 41.87 10.43 86 322660 49518 79372124
Drug hypersensitivity 41.86 10.43 1541 321205 297375 79124267
Blood pressure increased 41.67 10.43 603 322143 210757 79210885
Tunnel vision 41.62 10.43 41 322705 1537 79420105
Hemiparesis 41.60 10.43 45 322701 33688 79387954
Fluid retention 41.51 10.43 144 322602 69665 79351977
Intervertebral disc disorder 41.48 10.43 72 322674 4753 79416889
Cerebral haemorrhage 41.44 10.43 109 322637 57564 79364078
Lumbosacral radiculopathy 41.40 10.43 25 322721 443 79421199
Renal tubular necrosis 41.36 10.43 25 322721 25014 79396628
Uterine prolapse 41.22 10.43 31 322715 800 79420842
Hyperthermia 41.19 10.43 11 322735 18026 79403616
Musculoskeletal pain 41.15 10.43 612 322134 101742 79319900
Oliguria 41.13 10.43 8 322738 16301 79405341
Comminuted fracture 41.13 10.43 28 322718 615 79421027
Red blood cell count decreased 41.10 10.43 109 322637 57404 79364238
Spinal meningeal cyst 41.08 10.43 12 322734 24 79421618
Morton's neuralgia 40.57 10.43 13 322733 40 79421602
Ovarian disorder 40.29 10.43 25 322721 466 79421176
Pain in extremity 39.98 10.43 1831 320915 362707 79058935
Grip strength decreased 39.91 10.43 185 322561 21684 79399958
Plantar fasciitis 39.86 10.43 59 322687 3401 79418241
Nightmare 39.76 10.43 28 322718 25833 79395809
Urge incontinence 39.36 10.43 34 322712 1074 79420568
Miosis 39.28 10.43 8 322738 15781 79405861
Menopausal symptoms 39.26 10.43 44 322702 1919 79419723
Raynaud's phenomenon 39.22 10.43 33 322713 1005 79420637
Orthostatic hypotension 38.96 10.43 108 322638 56056 79365586
Transplant rejection 38.82 10.43 15 322731 19422 79402220
Osteomyelitis acute 38.71 10.43 25 322721 501 79421141
Toxic skin eruption 38.62 10.43 21 322725 22272 79399370
Obesity 38.55 10.43 259 322487 34866 79386776
Atrial fibrillation 38.50 10.43 566 322180 197320 79224322
Pathogen resistance 38.43 10.43 6 322740 14336 79407306
Humerus fracture 38.24 10.43 103 322643 9210 79412432
Injection site mass 38.01 10.43 17 322729 20167 79401475
Goitre 38.00 10.43 75 322671 5464 79416178
Dental alveolar anomaly 37.99 10.43 11 322735 21 79421621
Malocclusion 37.91 10.43 16 322730 125 79421517
Dizziness 37.65 10.43 1744 321002 524697 78896945
Benign neoplasm of skin 37.56 10.43 15 322731 100 79421542
Therapeutic response shortened 37.52 10.43 9 322737 15854 79405788
Gingival swelling 37.33 10.43 67 322679 4542 79417100
International normalised ratio increased 37.30 10.43 196 322550 84525 79337117
Bone fistula 37.00 10.43 14 322732 79 79421563
Extrapyramidal disorder 36.96 10.43 23 322723 22656 79398986
Akathisia 36.80 10.43 5 322741 13254 79408388
Immune reconstitution inflammatory syndrome 36.62 10.43 6 322740 13835 79407807
Upper limb fracture 36.57 10.43 157 322589 17810 79403832
Dermal cyst 36.51 10.43 50 322696 2682 79418960
Seronegative arthritis 36.47 10.43 67 322679 4625 79417017
Peripheral vascular disorder 36.24 10.43 92 322654 7938 79413704
Bladder pain 36.22 10.43 46 322700 2291 79419351
Neuritis 36.18 10.43 40 322706 1718 79419924
Shock haemorrhagic 36.08 10.43 18 322728 20042 79401600
Hepatic encephalopathy 36.06 10.43 27 322719 24139 79397503
Dysgeusia 36.02 10.43 115 322631 57062 79364580
Skin laceration 35.75 10.43 220 322526 28742 79392900
Dementia Alzheimer's type 35.66 10.43 31 322715 988 79420654
Vaginal disorder 35.66 10.43 24 322722 517 79421125
Cytopenia 35.60 10.43 19 322727 20364 79401278
Ejection fraction decreased 35.49 10.43 53 322693 34524 79387118
Nocturia 35.48 10.43 129 322617 13552 79408090
Cardiotoxicity 35.47 10.43 4 322742 12235 79409407
End stage renal disease 35.40 10.43 4 322742 12216 79409426
Neutrophil count increased 35.38 10.43 40 322706 29356 79392286
Groin pain 35.35 10.43 125 322621 12955 79408687
Hypomagnesaemia 34.98 10.43 87 322659 46824 79374818
Inappropriate antidiuretic hormone secretion 34.84 10.43 33 322713 26280 79395362
Aspergillus infection 34.75 10.43 17 322729 19144 79402498
Melanocytic naevus 34.73 10.43 66 322680 4675 79416967
Wound complication 34.73 10.43 68 322678 4925 79416717
Haemodialysis 34.69 10.43 15 322731 18153 79403489
Blood glucose decreased 34.62 10.43 33 322713 26201 79395441
Sputum culture positive 34.59 10.43 58 322688 3723 79417919
Spondylolysis 34.50 10.43 15 322731 127 79421515
Glomerular filtration rate decreased 34.35 10.43 25 322721 22677 79398965
Haemoptysis 34.32 10.43 114 322632 55885 79365757
Hemiplegia 34.32 10.43 9 322737 14930 79406712
Muscle rigidity 34.05 10.43 19 322727 19863 79401779
Tachypnoea 34.04 10.43 48 322698 32015 79389627
Decreased appetite 34.00 10.43 1091 321655 341327 79080315
Poor dental condition 33.99 10.43 24 322722 560 79421082
Renal injury 33.91 10.43 13 322733 16914 79404728
Jaw fistula 33.89 10.43 14 322732 103 79421539
Breast cancer stage III 33.85 10.43 102 322644 9724 79411918
Ischaemic stroke 33.80 10.43 51 322695 33080 79388562
Blood urea increased 33.71 10.43 94 322652 48696 79372946
Lacrimation increased 33.69 10.43 25 322721 22452 79399190
Psychomotor hyperactivity 33.65 10.43 13 322733 16836 79404806
Hormone level abnormal 33.58 10.43 41 322705 1961 79419681
Troponin increased 33.56 10.43 18 322728 19237 79402405
Upper-airway cough syndrome 33.56 10.43 114 322632 11579 79410063
Granuloma 33.31 10.43 91 322655 8206 79413436
Acute respiratory failure 33.30 10.43 126 322620 59415 79362227
Breast cyst 33.13 10.43 33 322713 1254 79420388
Hyperglycaemia 33.09 10.43 159 322587 70176 79351466
Injection site bruising 33.01 10.43 73 322673 40929 79380713
Blood lactate dehydrogenase increased 32.99 10.43 68 322678 39102 79382540
Oesophageal disorder 32.94 10.43 47 322699 2620 79419022
Electrocardiogram QRS complex prolonged 32.80 10.43 3 322743 10830 79410812
Loss of employment 32.56 10.43 46 322700 2541 79419101
Steroid therapy 32.36 10.43 14 322732 117 79421525
Bone formation increased 32.27 10.43 12 322734 64 79421578
Mood altered 32.12 10.43 16 322730 17831 79403811
Eye pruritus 31.98 10.43 22 322724 20548 79401094
Adenoidal disorder 31.92 10.43 15 322731 155 79421487
Walking aid user 31.86 10.43 102 322644 10046 79411596
Labelled drug-drug interaction medication error 31.81 10.43 39 322707 27611 79394031
Atrophy 31.80 10.43 41 322705 2073 79419569
Increased tendency to bruise 31.79 10.43 104 322642 10360 79411282
Cardiac failure congestive 31.78 10.43 396 322350 142006 79279636
Full blood count decreased 31.73 10.43 37 322709 26782 79394860
Pulmonary haemorrhage 31.72 10.43 10 322736 14707 79406935
Osteogenesis imperfecta 31.70 10.43 22 322724 499 79421143
Klebsiella infection 31.61 10.43 12 322734 15708 79405934
Frequent bowel movements 31.58 10.43 44 322702 29495 79392147
Stress 31.36 10.43 191 322555 79421 79342221
Cerebrovascular accident 31.31 10.43 441 322305 154851 79266791
Paranoia 31.27 10.43 20 322726 19412 79402230
Dialysis 31.11 10.43 18 322728 18444 79403198
Injection site pruritus 31.08 10.43 79 322667 42204 79379438
Graft versus host disease 31.01 10.43 11 322735 15015 79406627
Bone graft 30.99 10.43 25 322721 717 79420925
Trigger finger 30.98 10.43 59 322687 4186 79417456
No adverse event 30.95 10.43 65 322681 37127 79384515
Rash macular 30.94 10.43 43 322703 28856 79392786
Torsade de pointes 30.91 10.43 20 322726 19292 79402350
Hypophagia 30.90 10.43 88 322658 45279 79376363
Gastric disorder 30.87 10.43 258 322488 37175 79384467
Angiopathy 30.78 10.43 80 322666 7002 79414640
Vision blurred 30.72 10.43 277 322469 105621 79316021
Blood lactic acid increased 30.60 10.43 7 322739 12737 79408905
Mammogram abnormal 30.58 10.43 21 322725 468 79421174
Thrombosis 30.46 10.43 207 322539 83893 79337749
Body height decreased 30.44 10.43 90 322656 8490 79413152
Iron deficiency anaemia 30.43 10.43 193 322553 25479 79396163
Pneumocystis jirovecii pneumonia 30.39 10.43 53 322693 32455 79389187
Proteinuria 30.37 10.43 53 322693 32449 79389193
Hypophosphatasia 30.33 10.43 11 322735 54 79421588
Diverticulum intestinal 30.28 10.43 90 322656 8515 79413127
Actinic keratosis 30.21 10.43 72 322674 5970 79415672
Breast mass 30.08 10.43 77 322669 6677 79414965
Red cell distribution width increased 30.05 10.43 12 322734 15230 79406412
Mood swings 29.94 10.43 22 322724 19858 79401784
Hypertransaminasaemia 29.75 10.43 6 322740 11918 79409724
X-ray of pelvis and hip abnormal 29.66 10.43 8 322738 10 79421632
Extraskeletal ossification 29.55 10.43 12 322734 84 79421558
Wound infection 29.46 10.43 182 322564 23809 79397833
Hypersomnia 29.36 10.43 30 322716 23056 79398586
Lipase increased 29.28 10.43 15 322731 16451 79405191
Uterine leiomyoma 29.26 10.43 74 322672 6369 79415273
Arrhythmia 29.12 10.43 138 322608 61134 79360508
Metastases to central nervous system 28.99 10.43 15 322731 16360 79405282
Cyst 28.99 10.43 122 322624 13718 79407924
Hyperammonaemia 28.92 10.43 5 322741 11088 79410554
Gingival ulceration 28.82 10.43 27 322719 950 79420692
Enterocele 28.82 10.43 10 322736 42 79421600
Hypercalciuria 28.70 10.43 21 322725 519 79421123
Hallucination, auditory 28.53 10.43 25 322721 20668 79400974
Abdominal distension 28.50 10.43 328 322418 119322 79302320
Phlebolith 27.98 10.43 12 322734 98 79421544
Nasal congestion 27.93 10.43 188 322558 76364 79345278
Dyslipidaemia 27.93 10.43 107 322639 11526 79410116
Disseminated intravascular coagulation 27.89 10.43 65 322681 35777 79385865
Peripheral sensory neuropathy 27.84 10.43 9 322737 13024 79408618
C-reactive protein 27.83 10.43 62 322684 4917 79416725
Tooth resorption 27.78 10.43 9 322737 29 79421613
Traumatic fracture 27.75 10.43 27 322719 997 79420645
Heavy menstrual bleeding 27.67 10.43 11 322735 14000 79407642
Emphysema 27.65 10.43 135 322611 16165 79405477
Bone erosion 27.59 10.43 144 322602 17703 79403939
Intermittent claudication 27.53 10.43 50 322696 3421 79418221
Lupus-like syndrome 27.37 10.43 120 322626 13737 79407905
Bradyphrenia 27.30 10.43 5 322741 10635 79411007
Impaired quality of life 27.27 10.43 12 322734 14374 79407268
Second primary malignancy 27.16 10.43 12 322734 14338 79407304
Device malfunction 27.13 10.43 28 322718 21420 79400222
Osteopetrosis 27.11 10.43 9 322737 32 79421610
Tardive dyskinesia 27.05 10.43 5 322741 10566 79411076
Nasal disorder 27.03 10.43 52 322694 3717 79417925
Disease recurrence 26.89 10.43 90 322656 44019 79377623
Lip neoplasm 26.75 10.43 8 322738 18 79421624
Rash pruritic 26.75 10.43 423 322323 71206 79350436
Nodule 26.72 10.43 172 322574 22822 79398820
Lymphopenia 26.63 10.43 52 322694 30505 79391137
Infusion site pain 26.60 10.43 12 322734 14164 79407478
Leukoplakia 26.59 10.43 12 322734 112 79421530
Delusion 26.59 10.43 26 322720 20397 79401245
Haemodynamic instability 26.48 10.43 19 322727 17363 79404279
Bronchitis chronic 26.40 10.43 57 322689 4425 79417217
Muscle twitching 26.36 10.43 37 322709 24727 79396915
Tooth impacted 26.35 10.43 15 322731 237 79421405
Metastases to lung 26.20 10.43 21 322725 18142 79403500
Staphylococcal infection 26.15 10.43 134 322612 58161 79363481
Trigeminal neuralgia 26.14 10.43 50 322696 3559 79418083
Vascular calcification 26.12 10.43 27 322719 1073 79420569
Tendon disorder 26.09 10.43 76 322670 7110 79414532
Fracture malunion 25.96 10.43 12 322734 119 79421523
Cardiac failure acute 25.94 10.43 23 322723 18906 79402736
Sialoadenitis 25.81 10.43 36 322710 1965 79419677
Metastases to liver 25.71 10.43 47 322699 28267 79393375
Transfusion 25.70 10.43 29 322717 21301 79400341
Device occlusion 25.69 10.43 8 322738 11858 79409784
Ear congestion 25.67 10.43 44 322702 2875 79418767
Device difficult to use 25.64 10.43 11 322735 13374 79408268
Hepatic function abnormal 25.46 10.43 182 322564 72925 79348717
Neoplasm skin 25.43 10.43 32 322714 1579 79420063
Thalassaemia beta 25.43 10.43 7 322739 10 79421632
Haemolysis 25.40 10.43 10 322736 12802 79408840
Mixed incontinence 25.36 10.43 9 322737 41 79421601
Prostate cancer 25.36 10.43 61 322685 33207 79388435
Hypertensive crisis 25.29 10.43 28 322718 20742 79400900
Multiple-drug resistance 25.23 10.43 3 322743 8805 79412837
Bronchitis 25.19 10.43 700 322046 129944 79291698
Mental impairment 25.06 10.43 24 322722 19012 79402630
Otitis externa 25.05 10.43 39 322707 2351 79419291
Suspected suicide 25.02 10.43 6 322740 10570 79411072
Electrolyte imbalance 24.84 10.43 55 322691 30826 79390816
Substance abuse 24.84 10.43 6 322740 10520 79411122
Progressive multifocal leukoencephalopathy 24.83 10.43 28 322718 20572 79401070
Carotid artery stenosis 24.79 10.43 85 322661 8673 79412969
Rhinorrhoea 24.77 10.43 193 322553 75881 79345761
Erythema 24.72 10.43 701 322045 222589 79199053
Hand fracture 24.71 10.43 68 322678 6157 79415485
Asthma 24.70 10.43 719 322027 134376 79287266
Hormone therapy 24.66 10.43 6 322740 3 79421639
Colorectal cancer 24.63 10.43 3 322743 8644 79412998
Embolism 24.47 10.43 13 322733 13969 79407673
Anxiety disorder 24.38 10.43 53 322693 4134 79417508
Post transplant lymphoproliferative disorder 24.34 10.43 8 322738 11456 79410186
Spondylitis 24.33 10.43 57 322689 4674 79416968
Right ventricular failure 24.13 10.43 36 322710 23461 79398181
Mania 24.06 10.43 23 322723 18237 79403405
Osteolysis 24.02 10.43 55 322691 4443 79417199
Tubulointerstitial nephritis 24.01 10.43 77 322669 38158 79383484
Purulent discharge 24.01 10.43 66 322680 5973 79415669
Paraesthesia 23.97 10.43 537 322209 175786 79245856
Rheumatoid lung 23.89 10.43 53 322693 4192 79417450
Breast cancer in situ 23.88 10.43 24 322722 922 79420720
Throat tightness 23.88 10.43 48 322698 27859 79393783
Kidney transplant rejection 23.87 10.43 6 322740 10240 79411402
Myofascial pain syndrome 23.85 10.43 35 322711 2002 79419640
Acute pulmonary oedema 23.80 10.43 14 322732 14216 79407426
Cervical polyp 23.61 10.43 12 322734 149 79421493
Circulatory collapse 23.56 10.43 76 322670 37592 79384050
Hyperaesthesia 23.48 10.43 10 322736 12212 79409430
SARS-CoV-2 test positive 23.46 10.43 9 322737 11707 79409935
Lenticular opacities 23.46 10.43 19 322727 548 79421094
Musculoskeletal disorder 23.44 10.43 158 322588 21290 79400352
Bone fissure 23.20 10.43 12 322734 155 79421487
Heart rate decreased 23.08 10.43 178 322568 70138 79351504
Photosensitivity reaction 23.06 10.43 31 322715 21096 79400546
Mouth cyst 23.06 10.43 9 322737 56 79421586
Odontogenic cyst 23.04 10.43 7 322739 17 79421625
Dyspnoea exertional 23.03 10.43 233 322513 86840 79334802
Bone cyst 22.97 10.43 46 322700 3387 79418255
Breast fibrosis 22.95 10.43 6 322740 6 79421636
Polyneuropathy 22.92 10.43 39 322707 24112 79397530
Vulvovaginal dryness 22.90 10.43 36 322710 2188 79419454
BK virus infection 22.89 10.43 4 322742 8800 79412842
Injection site reaction 22.87 10.43 129 322617 54656 79366986
Oedema 22.85 10.43 640 322106 118940 79302702
Periarthritis 22.79 10.43 42 322704 2906 79418736
Enterococcal infection 22.73 10.43 18 322728 15642 79406000
Catatonia 22.71 10.43 4 322742 8752 79412890
Systemic inflammatory response syndrome 22.64 10.43 9 322737 11456 79410186
Pernicious anaemia 22.63 10.43 19 322727 577 79421065
Blood loss anaemia 22.56 10.43 123 322623 15375 79406267
Hypoalbuminaemia 22.49 10.43 32 322714 21265 79400377
Haemorrhage intracranial 22.46 10.43 45 322701 26148 79395494
Oesophageal discomfort 22.45 10.43 15 322731 319 79421323
Pulmonary arterial hypertension 22.43 10.43 51 322695 28315 79393327
Arteriosclerosis coronary artery 22.41 10.43 136 322610 17680 79403962
Blood phosphorus increased 22.36 10.43 7 322739 10340 79411302
Nervous system disorder 22.30 10.43 47 322699 26809 79394833
Cushingoid 22.23 10.43 87 322659 9465 79412177
Acne 22.23 10.43 48 322698 27142 79394500
Loss of personal independence in daily activities 22.19 10.43 558 322188 102022 79319620
Vascular device infection 22.12 10.43 7 322739 10269 79411373
Laryngeal ulceration 22.12 10.43 11 322735 130 79421512
Neuroma 22.06 10.43 14 322732 272 79421370
Salivary gland mass 22.04 10.43 9 322737 64 79421578
Wound secretion 22.04 10.43 65 322681 6123 79415519
Palatal disorder 21.95 10.43 17 322729 459 79421183
Chondromalacia 21.92 10.43 12 322734 175 79421467
Staphylococcal bacteraemia 21.92 10.43 11 322735 12207 79409435
Oropharyngeal pain 21.88 10.43 311 322435 109042 79312600
Generalised oedema 21.85 10.43 39 322707 23670 79397972
Pneumonia fungal 21.81 10.43 9 322737 11201 79410441
Respiratory acidosis 21.78 10.43 9 322737 11191 79410451
Hypernatraemia 21.75 10.43 16 322730 14435 79407207
Peritonitis 21.69 10.43 51 322695 27985 79393657
Cerebral infarction 21.63 10.43 103 322643 45573 79376069
Acrochordon 21.61 10.43 24 322722 1036 79420606
Tooth discolouration 21.56 10.43 25 322721 1132 79420510
Left ventricular dysfunction 21.55 10.43 28 322718 19333 79402309
Nasal polyps 21.53 10.43 72 322674 7255 79414387
Ear disorder 21.52 10.43 49 322697 3944 79417698
Ataxia 21.48 10.43 43 322703 24996 79396646
Lupus vulgaris 21.39 10.43 44 322702 3302 79418340
Urethral caruncle 21.36 10.43 9 322737 70 79421572
Chronic obstructive pulmonary disease 21.33 10.43 474 322272 84945 79336697
Nephropathy toxic 21.25 10.43 31 322715 20388 79401254
Hypoaesthesia oral 21.18 10.43 113 322633 14011 79407631
Skin haemorrhage 21.17 10.43 11 322735 11970 79409672
Anger 21.04 10.43 23 322723 17139 79404503
Toxic encephalopathy 20.98 10.43 10 322736 11430 79410212
Bladder cancer 20.96 10.43 29 322717 19497 79402145
Ventricular arrhythmia 20.94 10.43 5 322741 8835 79412807
Coagulopathy 20.92 10.43 75 322671 35931 79385711
Cytomegalovirus viraemia 20.90 10.43 13 322733 12808 79408834
White blood cell count increased 20.88 10.43 197 322549 74436 79347206
Product quality issue 20.86 10.43 69 322677 33871 79387771
Ileus 20.83 10.43 47 322699 26164 79395478
Product storage error 20.73 10.43 21 322725 16205 79405437
Fear of injection 20.69 10.43 72 322674 7402 79414240
Osteitis deformans 20.62 10.43 12 322734 198 79421444
Influenza like illness 20.61 10.43 188 322558 71519 79350123
Osteosclerosis 20.59 10.43 48 322698 3923 79417719
Thermohypoaesthesia 20.58 10.43 10 322736 112 79421530
Carcinoid tumour pulmonary 20.56 10.43 15 322731 369 79421273
Limb injury 20.49 10.43 196 322550 29332 79392310
Obstructive airways disorder 20.45 10.43 206 322540 31253 79390389
Pulmonary congestion 20.41 10.43 50 322696 27050 79394592
Burning sensation 20.40 10.43 146 322600 58486 79363156
Intestinal obstruction 20.38 10.43 97 322649 42923 79378719
Face oedema 20.35 10.43 53 322693 28083 79393559
Benign bone neoplasm 20.33 10.43 8 322738 51 79421591
Dry mouth 20.30 10.43 483 322263 87536 79334106
Hepatomegaly 20.29 10.43 28 322718 18846 79402796
Injection site warmth 20.28 10.43 18 322728 14789 79406853
Dental pulp disorder 20.22 10.43 6 322740 13 79421629
Type V hyperlipidaemia 20.22 10.43 23 322723 1020 79420622
Emotional distress 20.20 10.43 88 322658 39881 79381761
Acute coronary syndrome 20.17 10.43 34 322712 21099 79400543
Cataract nuclear 20.16 10.43 23 322723 1023 79420619
Oesophageal ulcer haemorrhage 20.10 10.43 18 322728 597 79421045
Staphylococcal sepsis 20.05 10.43 18 322728 14708 79406934
Peripheral coldness 20.03 10.43 21 322725 15949 79405693
Allergy to chemicals 20.03 10.43 37 322709 2565 79419077
Apathy 20.01 10.43 14 322732 12963 79408679
Otitis media 19.74 10.43 62 322684 6044 79415598
Petechiae 19.71 10.43 33 322713 20532 79401110
X-ray abnormal 19.70 10.43 60 322686 5753 79415889
Blood albumin decreased 19.65 10.43 43 322703 24200 79397442
Chronic kidney disease 19.64 10.43 172 322574 65982 79355660
Neurosensory hypoacusis 19.61 10.43 12 322734 218 79421424
Intestinal perforation 19.60 10.43 25 322721 17401 79404241
Throat irritation 19.59 10.43 92 322654 40854 79380788
Injection site urticaria 19.57 10.43 14 322732 12812 79408830
Dental prosthesis user 19.53 10.43 7 322739 33 79421609
Dermatitis acneiform 19.48 10.43 8 322738 9985 79411657
Gastrointestinal haemorrhage 19.48 10.43 452 322294 147267 79274375
Dermatitis exfoliative generalised 19.47 10.43 3 322743 7238 79414404
Cardiomyopathy 19.46 10.43 56 322690 28718 79392924
Scapula fracture 19.45 10.43 19 322727 705 79420937
Blood creatinine decreased 19.40 10.43 4 322742 7821 79413821
Epicondylitis 19.38 10.43 33 322713 2145 79419497
Joint ankylosis 19.36 10.43 33 322713 2147 79419495
Antinuclear antibody positive 19.29 10.43 73 322673 7817 79413825
Influenza 19.28 10.43 389 322357 129217 79292425
Vertigo positional 19.22 10.43 42 322704 3288 79418354
Essential hypertension 19.15 10.43 61 322685 5992 79415650
Therapeutic response unexpected 19.12 10.43 32 322714 19914 79401728
Pseudarthrosis 19.12 10.43 13 322733 285 79421357
Sight disability 19.07 10.43 10 322736 133 79421509
Sudden death 19.02 10.43 39 322707 22472 79399170
Pharyngeal swelling 19.02 10.43 4 322742 7715 79413927
Hospice care 18.97 10.43 9 322737 10315 79411327
Affect lability 18.94 10.43 11 322735 11248 79410394
Blood pressure abnormal 18.93 10.43 25 322721 17144 79404498
Amenorrhoea 18.93 10.43 4 322742 7688 79413954
Drug level below therapeutic 18.76 10.43 8 322738 9762 79411880
Face injury 18.69 10.43 44 322702 3620 79418022
Blood calcium decreased 18.67 10.43 66 322680 31753 79389889
Haemolytic anaemia 18.60 10.43 27 322719 17793 79403849
Crying 18.57 10.43 41 322705 23002 79398640
Pain of skin 18.57 10.43 19 322727 14594 79407048
Cardiac failure chronic 18.56 10.43 11 322735 11124 79410518
Gallbladder disorder 18.53 10.43 138 322608 19202 79402440
Mixed liver injury 18.52 10.43 4 322742 7574 79414068
Rash papular 18.49 10.43 38 322708 21878 79399764
Appendicitis 18.46 10.43 35 322711 20759 79400883
Benign breast neoplasm 18.41 10.43 20 322726 842 79420800
Skin burning sensation 18.34 10.43 16 322730 13256 79408386
Brain injury 18.33 10.43 12 322734 11505 79410137
Muscle spasticity 18.32 10.43 37 322709 21438 79400204
Blood alkaline phosphatase increased 18.26 10.43 167 322579 63497 79358145
Bronchopulmonary aspergillosis allergic 18.11 10.43 39 322707 3022 79418620
Sinus pain 18.07 10.43 44 322702 3698 79417944
Uterine cervix atrophy 18.06 10.43 4 322742 0 79421642
Traumatic occlusion 18.06 10.43 4 322742 0 79421642
Osteoma 18.05 10.43 9 322737 107 79421535
Pregnancy 18.02 10.43 177 322569 26674 79394968
Clonus 18.02 10.43 3 322743 6837 79414805
Hypocalcaemia 18.01 10.43 123 322623 49801 79371841
Drug level decreased 17.99 10.43 19 322727 14383 79407259
Hypovolaemic shock 17.95 10.43 14 322732 12262 79409380
Atrial flutter 17.82 10.43 38 322708 21587 79400055
Partial seizures 17.81 10.43 7 322739 8971 79412671
Hepatitis acute 17.79 10.43 22 322724 15520 79406122
Needle issue 17.76 10.43 16 322730 13052 79408590
Costochondritis 17.71 10.43 34 322712 2427 79419215
Myelodysplastic syndrome 17.68 10.43 63 322683 30238 79391404
Blood potassium increased 17.66 10.43 60 322686 29215 79392427
Pharyngeal oedema 17.63 10.43 24 322722 16248 79405394
Menopause 17.59 10.43 31 322715 2071 79419571
Musculoskeletal discomfort 17.59 10.43 139 322607 19696 79401946
Blood potassium decreased 17.58 10.43 113 322633 46399 79375243
Bone atrophy 17.52 10.43 6 322740 24 79421618
Vascular headache 17.49 10.43 7 322739 47 79421595
Glycosylated haemoglobin increased 17.46 10.43 32 322714 19228 79402414
Tympanosclerosis 17.46 10.43 5 322741 9 79421633
Parkinsonism 17.43 10.43 25 322721 16559 79405083
Grief reaction 17.41 10.43 12 322734 269 79421373
Aplasia pure red cell 17.39 10.43 5 322741 7805 79413837
Palpitations 17.37 10.43 385 322361 126225 79295417
Weight increased 17.29 10.43 1325 321421 276061 79145581
Stress cardiomyopathy 17.28 10.43 12 322734 11154 79410488
Foreign body 17.27 10.43 37 322709 2857 79418785
Leukoplakia oral 17.26 10.43 12 322734 273 79421369
Colitis ulcerative 17.25 10.43 77 322669 34665 79386977
Head discomfort 17.16 10.43 20 322726 14482 79407160
Major depression 17.16 10.43 77 322669 8903 79412739
Anhedonia 17.15 10.43 21 322725 14877 79406765
Urinary tract infection 17.13 10.43 922 321824 273590 79148052
Rectal polyp 17.07 10.43 27 322719 1650 79419992
Candida infection 17.05 10.43 88 322658 38126 79383516
Nerve degeneration 17.03 10.43 12 322734 279 79421363
Multiple fractures 17.00 10.43 71 322675 7955 79413687
Fibroadenoma of breast 16.97 10.43 13 322733 345 79421297
Heparin-induced thrombocytopenia 16.95 10.43 9 322737 9673 79411969
Parathyroid disorder 16.94 10.43 15 322731 490 79421152
Epstein-Barr virus infection 16.94 10.43 20 322726 14396 79407246
Bronchopulmonary aspergillosis 16.89 10.43 41 322705 22253 79399389
Abortion induced 16.88 10.43 4 322742 7105 79414537
Pulmonary vasculitis 16.86 10.43 18 322728 743 79420899
Cystitis haemorrhagic 16.85 10.43 8 322738 9164 79412478
Intentional product use issue 16.84 10.43 765 321981 151347 79270295
Breath odour 16.84 10.43 27 322719 1669 79419973
Iodine allergy 16.80 10.43 16 322730 575 79421067
Hypertonic bladder 16.79 10.43 46 322700 4155 79417487
Normal newborn 16.75 10.43 4 322742 7068 79414574
Hyperparathyroidism 16.75 10.43 39 322707 3185 79418457
Glucose tolerance impaired 16.73 10.43 71 322675 8013 79413629
Presbyopia 16.64 10.43 16 322730 582 79421060
Tooth dislocation 16.62 10.43 6 322740 29 79421613
Deformity 16.61 10.43 80 322666 9525 79412117
Renal cancer 16.58 10.43 15 322731 12211 79409431
Gastrooesophageal cancer 16.50 10.43 5 322741 12 79421630
Dermatitis bullous 16.48 10.43 20 322726 14225 79407417
Urinary retention 16.48 10.43 148 322598 56482 79365160
Vaginal dysplasia 16.45 10.43 6 322740 30 79421612
Activated partial thromboplastin time prolonged 16.44 10.43 20 322726 14208 79407434
Pneumatosis intestinalis 16.43 10.43 3 322743 6394 79415248
Polyuria 16.42 10.43 22 322724 14992 79406650
Hepatocellular carcinoma 16.37 10.43 8 322738 9013 79412629
Wrong product administered 16.34 10.43 8 322738 9004 79412638
Cyanosis 16.32 10.43 50 322696 25132 79396510
Prothrombin time prolonged 16.30 10.43 27 322719 16872 79404770
Benign neoplasm 16.29 10.43 21 322725 1062 79420580
Blood uric acid increased 16.28 10.43 18 322728 13342 79408300
Metatarsalgia 16.26 10.43 11 322735 239 79421403
Complication of device insertion 16.26 10.43 3 322743 6347 79415295
Erosive oesophagitis 16.24 10.43 36 322710 2846 79418796
Nystagmus 16.20 10.43 10 322736 9894 79411748
Jaundice 16.15 10.43 138 322608 53211 79368431
Fibroma 16.11 10.43 19 322727 876 79420766
Gestational diabetes 16.05 10.43 3 322743 6290 79415352
Radicular pain 16.05 10.43 13 322733 375 79421267
Intestinal ischaemia 16.03 10.43 18 322728 13252 79408390
Leukoencephalopathy 16.03 10.43 6 322740 7923 79413719
Hyperparathyroidism primary 16.03 10.43 14 322732 449 79421193
Product dispensing error 16.01 10.43 18 322728 13245 79408397
Hallucination, visual 15.97 10.43 73 322673 32656 79388986
Cerebral small vessel ischaemic disease 15.88 10.43 21 322725 1089 79420553
Post laminectomy syndrome 15.81 10.43 12 322734 314 79421328
Ketoacidosis 15.78 10.43 6 322740 7848 79413794
Deafness 15.78 10.43 142 322604 20895 79400747
Clostridium difficile colitis 15.76 10.43 72 322674 32211 79389431
Amino acid level increased 15.74 10.43 17 322729 711 79420931
Hepatitis C 15.74 10.43 15 322731 11910 79409732
Oral discharge 15.57 10.43 11 322735 257 79421385
Osteoporotic fracture 15.54 10.43 45 322701 4195 79417447
Chronic sinusitis 15.48 10.43 98 322648 12928 79408714
Tongue geographic 15.45 10.43 7 322739 66 79421576
Subdural haematoma 15.41 10.43 70 322676 31364 79390278
Euphoric mood 15.37 10.43 6 322740 7720 79413922
Hyperpyrexia 15.34 10.43 3 322743 6089 79415553
Periostitis 15.31 10.43 16 322730 644 79420998
Cold sweat 15.29 10.43 33 322713 18666 79402976
Coma scale abnormal 15.29 10.43 8 322738 8670 79412972
Device related infection 15.28 10.43 79 322667 34215 79387427
Pulmonary thrombosis 15.27 10.43 16 322730 12155 79409487
Cerebrovascular disorder 15.24 10.43 41 322705 3664 79417978
Pulseless electrical activity 15.23 10.43 21 322725 14139 79407503
Central nervous system lesion 15.22 10.43 19 322727 13349 79408293
Peri-implantitis 15.20 10.43 10 322736 207 79421435
Bone abscess 15.20 10.43 14 322732 482 79421160
Bradypnoea 15.20 10.43 3 322743 6049 79415593
Peritonitis bacterial 15.18 10.43 10 322736 9557 79412085
Pulmonary hypertension 15.18 10.43 123 322623 47957 79373685
Hepatic necrosis 15.15 10.43 9 322737 9091 79412551
Hypothyroidism 15.13 10.43 297 322449 52095 79369547
Tympanic membrane perforation 15.11 10.43 26 322720 1704 79419938
Vaginal haemorrhage 15.09 10.43 42 322704 21775 79399867
Abdominal abscess 15.08 10.43 5 322741 7122 79414520
Small intestinal obstruction 15.06 10.43 58 322688 27214 79394428
Cervical spinal stenosis 15.06 10.43 31 322715 2328 79419314
Hyperkeratosis 15.04 10.43 67 322679 7723 79413919
Wheezing 15.00 10.43 596 322150 116068 79305574
Haematemesis 15.00 10.43 296 322450 51968 79369674
Mandibular mass 15.00 10.43 10 322736 212 79421430
Back injury 14.97 10.43 83 322663 10440 79411202
Expired product administered 14.83 10.43 5 322741 7046 79414596
Osteodystrophy 14.80 10.43 5 322741 19 79421623
Skin plaque 14.79 10.43 13 322733 10732 79410910
Renal tubular disorder 14.73 10.43 4 322742 6482 79415160
Serum ferritin increased 14.69 10.43 11 322735 9836 79411806
Coccydynia 14.64 10.43 28 322718 1993 79419649
Avulsion fracture 14.62 10.43 11 322735 284 79421358
Oesophageal irritation 14.59 10.43 8 322738 117 79421525
Escherichia infection 14.57 10.43 32 322714 17985 79403657
Oesophagitis chemical 14.51 10.43 7 322739 77 79421565
Neutrophilia 14.50 10.43 7 322739 7944 79413698
Blood magnesium decreased 14.47 10.43 28 322718 16484 79405158
Immune effector cell-associated neurotoxicity syndrome 14.47 10.43 3 322743 5845 79415797
Hypersensitivity vasculitis 14.47 10.43 5 322741 6938 79414704
Skin fissures 14.45 10.43 19 322727 13054 79408588
Hepatitis cholestatic 14.44 10.43 21 322725 13831 79407811
Breast necrosis 14.44 10.43 7 322739 78 79421564
Personality change 14.37 10.43 12 322734 10158 79411484
Meniere's disease 14.35 10.43 9 322737 171 79421471
Enteritis 14.35 10.43 23 322723 14560 79407082
Splenomegaly 14.32 10.43 40 322706 20714 79400928
Bladder prolapse 14.32 10.43 23 322723 1424 79420218
Sleep disorder 14.32 10.43 451 322295 85226 79336416
Therapy change 14.30 10.43 6 322740 7393 79414249
Intentional dose omission 14.29 10.43 9 322737 8808 79412834
Speech disorder 14.26 10.43 146 322600 54299 79367343
Vaginal prolapse 14.26 10.43 11 322735 295 79421347
Wall motion score index abnormal 14.26 10.43 9 322737 173 79421469
Stupor 14.23 10.43 5 322741 6867 79414775
Sinus polyp 14.23 10.43 14 322732 524 79421118
Jaw clicking 14.23 10.43 5 322741 22 79421620
Central nervous system mass 14.22 10.43 9 322737 174 79421468
Hepatic cancer 14.18 10.43 13 322733 10516 79411126
Injection site extravasation 14.17 10.43 11 322735 9658 79411984
Euglycaemic diabetic ketoacidosis 14.14 10.43 5 322741 6839 79414803
Gastric ulcer 14.12 10.43 204 322542 33701 79387941
Metastases to bone 14.11 10.43 51 322695 24376 79397266
Conductive deafness 14.10 10.43 10 322736 235 79421407
Uterine polyp 14.09 10.43 24 322722 1560 79420082
Onychomadesis 14.08 10.43 50 322696 5192 79416450
Mastoid disorder 14.05 10.43 5 322741 23 79421619
Osteorrhagia 14.04 10.43 4 322742 7 79421635
Metabolic disorder 14.00 10.43 10 322736 9160 79412482
Labile hypertension 13.99 10.43 14 322732 535 79421107
Osteocalcin decreased 13.99 10.43 6 322740 49 79421593
Hiccups 13.97 10.43 12 322734 10019 79411623
Bacterial infection 13.97 10.43 72 322674 31208 79390434
Atrioventricular block 13.95 10.43 22 322724 14019 79407623
Genital haemorrhage 13.94 10.43 4 322742 6251 79415391
Breast neoplasm 13.90 10.43 18 322728 914 79420728
Dermatitis exfoliative 13.85 10.43 14 322732 10815 79410827
Incorrect product administration duration 13.78 10.43 17 322729 12005 79409637
Amylase increased 13.77 10.43 15 322731 11194 79410448
Paraesthesia oral 13.73 10.43 40 322706 20431 79401211
Transplant dysfunction 13.73 10.43 6 322740 7215 79414427
Paralysis 13.72 10.43 20 322726 13157 79408485
Acidosis 13.70 10.43 38 322708 19724 79401918
Arteriosclerosis 13.66 10.43 123 322623 18104 79403538
Crepitations 13.59 10.43 78 322668 9939 79411703
Peripheral ischaemia 13.56 10.43 11 322735 9446 79412196
Resorption bone decreased 13.54 10.43 3 322743 0 79421642
Lipoma of breast 13.54 10.43 3 322743 0 79421642
External fixation of fracture 13.54 10.43 3 322743 0 79421642
Intestinal mucosal tear 13.54 10.43 3 322743 0 79421642
Erythroplasia 13.54 10.43 3 322743 0 79421642
Bartholin's cyst 13.54 10.43 3 322743 0 79421642
Deafness traumatic 13.54 10.43 3 322743 0 79421642
Ammonia increased 13.51 10.43 7 322739 7628 79414014
Drug specific antibody present 13.51 10.43 5 322741 6647 79414995
Drug dependence 13.47 10.43 103 322643 40666 79380976
Bursa disorder 13.47 10.43 10 322736 253 79421389
Performance status decreased 13.45 10.43 4 322742 6109 79415533
Ankle arthroplasty 13.43 10.43 23 322723 1502 79420140
Therapeutic product effect incomplete 13.39 10.43 454 322292 141191 79280451
Actinic elastosis 13.39 10.43 6 322740 55 79421587
Poliomyelitis 13.30 10.43 6 322740 56 79421586
Sinus tachycardia 13.28 10.43 91 322655 36817 79384825
Anal abscess 13.27 10.43 11 322735 9344 79412298
Prescribed underdose 13.27 10.43 180 322566 29334 79392308
Oesophagitis haemorrhagic 13.26 10.43 15 322731 661 79420981
Incision site cellulitis 13.24 10.43 8 322738 142 79421500
Nail operation 13.22 10.43 15 322731 663 79420979
Coronary arterial stent insertion 13.22 10.43 4 322742 6040 79415602
Cutis laxa 13.14 10.43 8 322738 144 79421498
Psychiatric symptom 13.13 10.43 6 322740 7029 79414613
Drug abuser 13.11 10.43 4 322742 6009 79415633
Stomatitis necrotising 13.09 10.43 9 322737 201 79421441
Pleuritic pain 13.09 10.43 78 322668 10074 79411568
Coronavirus infection 13.08 10.43 7 322739 7490 79414152
Calculus urinary 13.05 10.43 30 322716 2430 79419212
Electrocardiogram ST segment elevation 13.03 10.43 9 322737 8388 79413254
Protein urine present 13.02 10.43 13 322733 10099 79411543
Dyspepsia 13.00 10.43 551 322195 108136 79313506
Pulse absent 12.99 10.43 13 322733 10090 79411552
Oesophageal spasm 12.98 10.43 37 322709 3419 79418223
Encephalitis 12.96 10.43 25 322721 14735 79406907
Lip neoplasm malignant stage unspecified 12.96 10.43 5 322741 30 79421612
Subarachnoid haemorrhage 12.90 10.43 53 322693 24412 79397230
Pyogenic granuloma 12.88 10.43 13 322733 502 79421140
Immunodeficiency 12.87 10.43 45 322701 21723 79399919
Acute generalised exanthematous pustulosis 12.86 10.43 32 322714 17222 79404420
Oesophageal injury 12.85 10.43 7 322739 101 79421541
Laboratory test abnormal 12.85 10.43 64 322682 27984 79393658
Bone callus excessive 12.82 10.43 5 322741 31 79421611
C-reactive protein increased 12.82 10.43 642 322104 128385 79293257
Human herpesvirus 6 infection 12.79 10.43 3 322743 5367 79416275
Labyrinthitis 12.79 10.43 33 322713 2875 79418767
Pneumothorax 12.76 10.43 65 322681 28258 79393384
Ilium fracture 12.69 10.43 10 322736 277 79421365
Hereditary angioedema 12.67 10.43 3 322743 5332 79416310
Hypoxic-ischaemic encephalopathy 12.65 10.43 8 322738 7812 79413830
Atelectasis 12.62 10.43 192 322554 32065 79389577
Complications of transplanted kidney 12.57 10.43 5 322741 6361 79415281
Retching 12.56 10.43 33 322713 17434 79404208
Spontaneous haemorrhage 12.53 10.43 16 322730 801 79420841
Presyncope 12.52 10.43 106 322640 40948 79380694
Alanine aminotransferase increased 12.51 10.43 534 322212 162036 79259606
Parathyroid tumour benign 12.50 10.43 16 322730 803 79420839
Sputum culture 12.49 10.43 9 322737 217 79421425
Sexual dysfunction 12.48 10.43 8 322738 7755 79413887
Paranasal sinus discomfort 12.40 10.43 43 322703 4413 79417229
Lung neoplasm malignant 12.40 10.43 64 322682 27728 79393914
Catheter site infection 12.37 10.43 6 322740 6789 79414853
Hepatitis fulminant 12.35 10.43 7 322739 7255 79414387
Impaired fasting glucose 12.29 10.43 12 322734 445 79421197
Lymphadenopathy 12.28 10.43 147 322599 53100 79368542
Injection site induration 12.22 10.43 13 322733 9806 79411836
Respiratory syncytial virus infection 12.21 10.43 12 322734 9390 79412252
Abnormal dreams 12.20 10.43 17 322729 11395 79410247
Drug dose omission by device 12.19 10.43 5 322741 6245 79415397
Eczema 12.17 10.43 106 322640 40712 79380930
Knee deformity 12.14 10.43 20 322726 1265 79420377
Influenza B virus test positive 12.13 10.43 11 322735 371 79421271
Injection site rash 12.10 10.43 35 322711 17919 79403723
Dysplastic naevus syndrome 12.10 10.43 4 322742 14 79421628
Systemic candida 12.09 10.43 6 322740 6700 79414942
Lacunar infarction 12.08 10.43 52 322694 5905 79415737
Deep vein thrombosis 12.04 10.43 385 322361 120534 79301108
Leukocytosis 12.02 10.43 115 322631 43340 79378302
Gait inability 12.01 10.43 318 322428 58599 79363043
Fear 11.99 10.43 47 322699 21939 79399703
Eustachian tube disorder 11.98 10.43 6 322740 72 79421570
Post procedural constipation 11.98 10.43 6 322740 72 79421570
Bradykinesia 11.98 10.43 9 322737 8034 79413608
Parkinson's disease 11.92 10.43 23 322723 1648 79419994
Diabetes mellitus inadequate control 11.91 10.43 54 322692 24210 79397432
Mental disorder 11.86 10.43 76 322670 31226 79390416
Interstitial lung disease 11.82 10.43 356 322390 112244 79309398
Musculoskeletal deformity 11.82 10.43 22 322724 1534 79420108
Memory impairment 11.80 10.43 353 322393 111381 79310261
Immune thrombocytopenia 11.79 10.43 35 322711 17770 79403872
Parophthalmia 11.77 10.43 11 322735 386 79421256
Dysstasia 11.76 10.43 65 322681 27681 79393961
Persistent depressive disorder 11.72 10.43 19 322727 1186 79420456
Bone pain 11.69 10.43 302 322444 55440 79366202
Erythema marginatum 11.68 10.43 4 322742 16 79421626
Numb chin syndrome 11.68 10.43 4 322742 16 79421626
Callus formation delayed 11.68 10.43 4 322742 16 79421626
Fibrous dysplasia of bone 11.68 10.43 4 322742 16 79421626
Sluggishness 11.67 10.43 6 322740 6566 79415076
Hepatosplenic T-cell lymphoma 11.63 10.43 16 322730 862 79420780
Confusional state 11.57 10.43 1463 321283 316534 79105108
Tooth erosion 11.51 10.43 11 322735 397 79421245
Reaction to food additive 11.47 10.43 3 322743 3 79421639
Osteoarthropathy 11.47 10.43 3 322743 3 79421639
Macrognathia 11.47 10.43 3 322743 3 79421639
Anxiety 11.44 10.43 1161 321585 247351 79174291
Pharyngitis streptococcal 11.41 10.43 16 322730 10698 79410944
Pneumonia cytomegaloviral 11.40 10.43 3 322743 4966 79416676
Red blood cells urine positive 11.38 10.43 3 322743 4960 79416682
Gastrointestinal tract adenoma 11.36 10.43 12 322734 489 79421153
Cytomegalovirus chorioretinitis 11.36 10.43 4 322742 5486 79416156
Sinus bradycardia 11.34 10.43 58 322688 25189 79396453
Diplopia 11.32 10.43 84 322662 33382 79388260
Dental cyst 11.31 10.43 4 322742 18 79421624
Multiple sclerosis 11.29 10.43 49 322697 22233 79399409
Brain abscess 11.29 10.43 3 322743 4933 79416709
Granulocytopenia 11.27 10.43 18 322728 11413 79410229
Infusion site erythema 11.25 10.43 13 322733 9447 79412195
Product dose omission in error 11.24 10.43 9 322737 7779 79413863
Motor dysfunction 11.24 10.43 27 322719 14706 79406936
Dystrophic calcification 11.21 10.43 7 322739 132 79421510
Electroencephalogram abnormal 11.18 10.43 4 322742 5430 79416212
Intraocular lens implant 11.18 10.43 11 322735 412 79421230
Cardiac septal defect 11.16 10.43 10 322736 332 79421310
Clavicle fracture 11.10 10.43 41 322705 4340 79417302
Scab 11.05 10.43 16 322730 10556 79411086
Guillain-Barre syndrome 11.01 10.43 12 322734 8953 79412689
Red cell distribution width decreased 10.97 10.43 25 322721 2013 79419629
Congenital bowing of long bones 10.97 10.43 4 322742 20 79421622
Salivary gland adenoma 10.97 10.43 4 322742 20 79421622
Restrictive pulmonary disease 10.96 10.43 29 322717 2566 79419076
Injection site haematoma 10.92 10.43 3 322743 4824 79416818
Infusion site extravasation 10.86 10.43 15 322731 10093 79411549
Product monitoring error 10.85 10.43 12 322734 8894 79412748
Post procedural fever 10.84 10.43 12 322734 516 79421126
Spinal fusion surgery 10.84 10.43 46 322700 5192 79416450
Portal vein thrombosis 10.83 10.43 5 322741 5822 79415820
Device leakage 10.80 10.43 17 322729 10839 79410803
Crohn's disease 10.79 10.43 25 322721 2035 79419607
Coordination abnormal 10.78 10.43 35 322711 17277 79404365
Increased appetite 10.77 10.43 20 322726 11958 79409684
Lipoma 10.77 10.43 32 322714 3027 79418615
Cardiac tamponade 10.76 10.43 13 322733 9263 79412379
Joint destruction 10.72 10.43 50 322696 5875 79415767
Enchondromatosis 10.70 10.43 5 322741 51 79421591
Pneumonectomy 10.70 10.43 6 322740 92 79421550
Cubital tunnel syndrome 10.70 10.43 10 322736 351 79421291
Weight bearing difficulty 10.69 10.43 33 322713 3188 79418454
Hypoglycaemic coma 10.69 10.43 3 322743 4757 79416885
Tonsillitis 10.68 10.43 7 322739 6707 79414935
Ganglioneuroma 10.68 10.43 7 322739 144 79421498
N-terminal prohormone brain natriuretic peptide increased 10.67 10.43 3 322743 4752 79416890
Blood culture positive 10.67 10.43 11 322735 8418 79413224
Respiratory disorder 10.66 10.43 123 322623 44733 79376909
Hiatus hernia strangulated 10.65 10.43 8 322738 206 79421436
Gingivitis ulcerative 10.64 10.43 9 322737 276 79421366
Intervertebral disc displacement 10.62 10.43 11 322735 438 79421204
Lip swelling 10.60 10.43 110 322636 40801 79380841
Neurological decompensation 10.58 10.43 4 322742 5249 79416393
Sensory loss 10.56 10.43 23 322723 12968 79408674
Breast hyperplasia 10.55 10.43 7 322739 147 79421495
Poor personal hygiene 10.55 10.43 12 322734 532 79421110
Portal hypertension 10.53 10.43 8 322738 7100 79414542
Bone sarcoma 10.53 10.43 6 322740 95 79421547
Psychomotor skills impaired 10.53 10.43 4 322742 5233 79416409
Abdominal bruit 10.51 10.43 4 322742 23 79421619
Hypoacusis 10.49 10.43 176 322570 29974 79391668
Purpura 10.48 10.43 42 322704 19485 79402157
Hypereosinophilic syndrome 10.48 10.43 12 322734 536 79421106
Cell death 10.48 10.43 3 322743 4696 79416946
Abscess neck 10.47 10.43 18 322728 1179 79420463
Complications of bone marrow transplant 10.47 10.43 13 322733 633 79421009

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M05BA04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates
ATC M05BB03 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB05 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB06 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
FDA CS M0006519 Diphosphonates
FDA EPC N0000175579 Bisphosphonate
CHEBI has role CHEBI:50643 dimethylallyltranstransferase inhibitors
CHEBI has role CHEBI:50646 antiosteoporotic
MeSH PA D050071 Bone Density Conservation Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteitis deformans indication 2089002 DOID:5408
Postmenopausal osteoporosis indication 102447009
Hypogonadal Osteoporosis in Males indication
Prevention of Glucocorticoid-Induced Osteoporosis indication
Glucocorticoid Induced Osteoporosis indication
Complex regional pain syndrome off-label use 128200000 DOID:3223
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Esophagitis contraindication 16761005 DOID:11963
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Ulcer of esophagus contraindication 30811009
Sarcoidosis contraindication 31541009 DOID:11335
Vitamin D deficiency contraindication 34713006
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Atrial fibrillation contraindication 49436004 DOID:0060224
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Stricture of esophagus contraindication 63305008
Hypercalcemia contraindication 66931009 DOID:12678
Fracture of femur contraindication 71620000
Duodenitis contraindication 72007001 DOID:8643
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Bed-ridden contraindication 160685001
Acute peptic ulcer contraindication 196682000
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Aseptic necrosis of bone of jaw contraindication 441809006
High Grade Dysplasia associated with Barrett's Esophagus contraindication
Esophageal Obstruction contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.27 acidic
pKa2 5.34 acidic
pKa3 6.32 acidic
pKa4 10.39 acidic
pKa5 12.82 acidic
pKa6 10.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 70MG BASE/75ML ALENDRONATE SODIUM NOVITIUM PHARMA A214512 May 11, 2023 RX SOLUTION ORAL Nov. 20, 2023 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Farnesyl pyrophosphate synthase Enzyme INHIBITOR Ki 7.35 CHEMBL CHEMBL
Protein farnesyltransferase subunit beta Enzyme IC50 7.30 WOMBAT-PK
Farnesyl pyrophosphate synthase Enzyme Ki 7.02 CHEMBL
Farnesyl pyrophosphate synthase Enzyme IC50 5.77 CHEMBL
Isopentenyl-diphosphate Delta-isomerase 1 Enzyme IC50 5.77 CHEMBL
Farnesyl pyrophosphate synthase Enzyme IC50 4.82 CHEMBL
Farnesyl pyrophosphate synthase, EC 2.5.1.1, EC 2.5.1.10 Unclassified Ki 7.04 CHEMBL

External reference:

IDSource
4020932 VUID
N0000148414 NUI
D00939 KEGG_DRUG
121268-17-5 SECONDARY_CAS_RN
203152 RXNORM
C0771311 UMLSCUI
CHEBI:2567 CHEBI
212 PDB_CHEM_ID
CHEMBL870 ChEMBL_ID
CHEMBL675 ChEMBL_ID
DB00630 DRUGBANK_ID
2088 PUBCHEM_CID
3141 IUPHAR_LIGAND_ID
6462 INN_ID
X1J18R4W8P UNII
1217581008 SNOMEDCT_US
391729003 SNOMEDCT_US
391730008 SNOMEDCT_US
421552005 SNOMEDCT_US
96290008 SNOMEDCT_US
D019386 MESH_DESCRIPTOR_UI
4020932 VANDF
131536 MMSL
4146 MMSL
d03849 MMSL
005056 NDDF
005057 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FOSAMAX HUMAN PRESCRIPTION DRUG LABEL 1 0006-0031 TABLET 70 mg ORAL NDA 28 sections
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0270 TABLET 70 mg ORAL NDA 27 sections
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0710 TABLET 70 mg ORAL NDA 27 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-0282 SOLUTION 70 mg ORAL ANDA 28 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1676 TABLET 5 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1676 TABLET 5 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1678 TABLET 10 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1678 TABLET 10 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1679 TABLET 35 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1679 TABLET 35 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1680 TABLET 40 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1680 TABLET 40 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1681 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1681 TABLET 70 mg ORAL ANDA 29 sections
Binosto HUMAN PRESCRIPTION DRUG LABEL 1 0178-0101 TABLET, EFFERVESCENT 70 mg ORAL NDA 20 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-696 TABLET 35 mg ORAL ANDA 27 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-697 TABLET 70 mg ORAL ANDA 27 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-718 TABLET 35 mg ORAL ANDA 29 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-718 TABLET 35 mg ORAL ANDA 29 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-719 TABLET 70 mg ORAL ANDA 29 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-719 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-631 TABLET 10 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-631 TABLET 10 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-632 TABLET 35 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-632 TABLET 35 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-633 TABLET 70 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-633 TABLET 70 mg ORAL ANDA 27 sections
Binosto HUMAN PRESCRIPTION DRUG LABEL 1 17139-400 TABLET, EFFERVESCENT 70 mg ORAL NDA 21 sections
Binosto HUMAN PRESCRIPTION DRUG LABEL 1 17139-400 TABLET, EFFERVESCENT 70 mg ORAL NDA 21 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-901 TABLET 35 mg ORAL ANDA 27 sections