alendronic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium metabolism regulator, pharmaceutical aid 112 66376-36-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alendronate monosodium salt trihydrate
  • alendronate sodium trihydrate
  • alendronate sodium hydrate
  • alendronate
  • alendronic acid
  • alendronate sodium
  • aminohydroxybutane bisphosphonate
  • MK-217
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
  • Molecular weight: 249.10
  • Formula: C4H13NO7P2
  • CLOGP: -5.64
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 6
  • TPSA: 161.31
  • ALOGS: -1.17
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg O
10 mg O
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 45 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.68 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.33 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.22 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 29, 1995 FDA MERCK AND CO INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Femur fracture 7640.27 10.20 3846 256263 33151 46392802
Low turnover osteopathy 3100.13 10.20 1090 259019 3199 46422754
Osteonecrosis 2892.01 10.20 1796 258313 23948 46402005
Osteonecrosis of jaw 2504.93 10.20 1834 258275 32568 46393385
Intramedullary rod insertion 2215.78 10.20 713 259396 1430 46424523
Stress fracture 1595.34 10.20 784 259325 6343 46419610
Osteoarthritis 1407.37 10.20 1731 258378 60294 46365659
Atypical femur fracture 1379.28 10.20 635 259474 4362 46421591
Fracture nonunion 1191.16 10.20 463 259646 1941 46424012
Osteomyelitis 1074.61 10.20 935 259174 21448 46404505
Pemphigus 1051.66 10.20 1279 258830 43995 46381958
Open reduction of fracture 1029.85 10.20 345 259764 829 46425124
Dental caries 1027.49 10.20 669 259440 9710 46416243
Anaemia postoperative 951.85 10.20 383 259726 1793 46424160
Hyperlipidaemia 948.04 10.20 803 259306 17736 46408217
Tooth disorder 940.71 10.20 883 259226 22420 46403533
Impaired healing 899.11 10.20 1066 259043 35677 46390276
Osteoporosis 843.64 10.20 1085 259024 39523 46386430
Systemic lupus erythematosus 791.60 10.20 1353 258756 63827 46362126
Spinal osteoarthritis 762.91 10.20 632 259477 13519 46412434
Osteopenia 753.20 10.20 678 259431 16283 46409670
Gastrooesophageal reflux disease 740.73 10.20 1416 258693 72928 46353025
Oral infection 705.89 10.20 379 259730 3753 46422200
Glossodynia 705.47 10.20 1042 259067 43331 46382622
Jaw disorder 700.21 10.20 406 259703 4724 46421229
Vitamin D deficiency 669.42 10.20 530 259579 10604 46415349
Toxicity to various agents 667.12 10.20 178 259931 211588 46214365
Completed suicide 656.69 10.20 39 260070 145881 46280072
Foot fracture 639.47 10.20 661 259448 18921 46407032
Bone disorder 630.49 10.20 663 259446 19370 46406583
Intervertebral disc degeneration 600.77 10.20 536 259573 12716 46413237
Bursitis 593.18 10.20 639 259470 19203 46406750
Death 588.43 10.20 602 259507 334946 46091007
Off label use 585.64 10.20 756 259353 379085 46046868
Hypercholesterolaemia 582.41 10.20 496 259613 11034 46414919
Fall 544.76 10.20 3411 256698 325686 46100267
Tooth fracture 540.05 10.20 436 259673 8979 46416974
Nausea 539.11 10.20 1997 258112 685457 45740496
Fracture delayed union 503.09 10.20 245 259864 1937 46424016
Temporomandibular joint syndrome 497.66 10.20 285 259824 3233 46422720
Diarrhoea 496.40 10.20 1540 258569 558062 45867891
Exostosis of jaw 473.99 10.20 198 259911 1038 46424915
Device failure 472.75 10.20 335 259774 5624 46420329
Vomiting 458.86 10.20 1168 258941 451626 45974327
Gingival disorder 433.05 10.20 253 259856 2988 46422965
Bone density decreased 427.34 10.20 387 259722 9365 46416588
Pathological fracture 420.03 10.20 351 259758 7599 46418354
Arthropathy 413.69 10.20 1222 258887 83478 46342475
Scoliosis 402.31 10.20 309 259800 5901 46420052
Hand deformity 396.35 10.20 700 259409 33874 46392079
Exostosis 380.14 10.20 371 259738 9892 46416061
Rib fracture 374.07 10.20 494 259615 18460 46407493
Medical device removal 371.87 10.20 169 259940 1121 46424832
Periodontal disease 368.03 10.20 182 259927 1493 46424460
Diverticulum 367.13 10.20 379 259730 10827 46415126
Spondylolisthesis 366.28 10.20 223 259886 2855 46423098
Bone loss 346.79 10.20 205 259904 2478 46423475
Calcium deficiency 345.39 10.20 143 259966 730 46425223
Drug ineffective 340.22 10.20 2300 257809 675538 45750415
Pyrexia 337.40 10.20 920 259189 347882 46078071
Hip fracture 334.99 10.20 561 259548 25995 46399958
Headache 328.68 10.20 1461 258648 476891 45949062
Adverse event 327.77 10.20 641 259468 33543 46392410
Internal fixation of fracture 323.19 10.20 131 259978 627 46425326
Spinal compression fracture 323.13 10.20 379 259730 12524 46413429
Tooth extraction 321.83 10.20 338 259771 9855 46416098
Febrile neutropenia 320.35 10.20 68 260041 94559 46331394
Blood cholesterol increased 319.75 10.20 696 259413 39317 46386636
Abdominal discomfort 317.42 10.20 1671 258438 149494 46276459
Product dose omission issue 313.75 10.20 286 259823 168234 46257719
Tooth loss 308.58 10.20 273 259836 6400 46419553
Rotator cuff syndrome 308.14 10.20 351 259758 11232 46414721
Dyspnoea 307.78 10.20 1655 258454 513893 45912060
Neutropenia 301.58 10.20 215 259894 142989 46282964
Intentional overdose 296.17 10.20 16 260093 64928 46361025
Knee arthroplasty 295.92 10.20 498 259611 23167 46402786
Hip arthroplasty 294.43 10.20 430 259679 17682 46408271
Wound 292.67 10.20 700 259409 42102 46383851
Lumbar spinal stenosis 287.57 10.20 220 259889 4175 46421778
Jaw fracture 286.31 10.20 178 259931 2371 46423582
Resorption bone increased 270.25 10.20 130 259979 997 46424956
Tooth abscess 267.59 10.20 341 259768 12292 46413661
Muscle strain 261.94 10.20 252 259857 6597 46419356
Acute kidney injury 259.93 10.20 581 259528 235274 46190679
Drug abuse 259.64 10.20 26 260083 63382 46362571
Kyphosis 259.26 10.20 161 259948 2140 46423813
Loose tooth 258.78 10.20 183 259926 3061 46422892
Oral disorder 257.04 10.20 265 259844 7557 46418396
Pelvic fracture 253.19 10.20 317 259792 11222 46414731
Large intestine polyp 252.34 10.20 263 259846 7598 46418355
Periodontitis 249.68 10.20 184 259925 3292 46422661
Alopecia 249.57 10.20 1654 258455 160760 46265193
Gingivitis 249.33 10.20 256 259853 7264 46418689
Hypothyroidism 245.69 10.20 541 259568 30797 46395156
Radius fracture 244.78 10.20 179 259930 3163 46422790
Cataract 241.67 10.20 676 259433 44739 46381214
Blood loss anaemia 240.77 10.20 267 259842 8290 46417663
Disease progression 236.74 10.20 106 260003 91194 46334759
Bone graft 232.23 10.20 109 260000 786 46425167
Suicide attempt 226.83 10.20 22 260087 55014 46370939
Hypotension 223.39 10.20 615 259494 231974 46193979
Wrist fracture 222.63 10.20 297 259812 11206 46414747
Basal cell carcinoma 215.91 10.20 400 259709 20087 46405866
Fibrocystic breast disease 213.83 10.20 113 259996 1080 46424873
Limb asymmetry 213.53 10.20 100 260009 717 46425236
Meniscus injury 213.21 10.20 212 259897 5784 46420169
Drug interaction 211.09 10.20 516 259593 202578 46223375
Tonsillar disorder 210.41 10.20 104 260005 852 46425101
Hiatus hernia 207.69 10.20 369 259740 17933 46408020
Injection site pain 206.36 10.20 176 259933 106976 46318977
Malaise 206.25 10.20 1047 259062 330185 46095768
Exposure during pregnancy 205.66 10.20 180 259929 108032 46317921
Pruritus 204.67 10.20 680 259429 241672 46184281
Lumbar radiculopathy 204.44 10.20 127 259982 1689 46424264
Tibia fracture 204.28 10.20 182 259927 4307 46421646
Edentulous 200.58 10.20 70 260039 199 46425754
Uterine disorder 199.20 10.20 145 259964 2543 46423410
Tonsillectomy 195.62 10.20 94 260015 719 46425234
Abortion spontaneous 195.17 10.20 12 260097 43634 46382319
Ulna fracture 195.03 10.20 103 260006 983 46424970
Cerumen impaction 193.96 10.20 105 260004 1058 46424895
Hypertension 191.78 10.20 1801 258308 194555 46231398
Synovial cyst 190.99 10.20 220 259889 7126 46418827
Pericarditis 187.47 10.20 413 259696 23514 46402439
Fistula discharge 187.02 10.20 95 260014 830 46425123
Haemorrhoids 185.94 10.20 357 259752 18420 46407533
Ligament sprain 184.56 10.20 259 259850 10260 46415693
Oral cavity fistula 184.47 10.20 87 260022 635 46425318
Blood parathyroid hormone decreased 184.40 10.20 170 259939 4211 46421742
Malignant neoplasm progression 183.62 10.20 66 260043 64860 46361093
Cardiac arrest 182.12 10.20 142 259967 90257 46335696
Cataract operation 180.09 10.20 163 259946 3940 46422013
White blood cell count decreased 180.02 10.20 216 259893 112015 46313938
Fibula fracture 178.40 10.20 142 259967 2862 46423091
Patellofemoral pain syndrome 174.64 10.20 76 260033 448 46425505
Anti-cyclic citrullinated peptide antibody positive 173.85 10.20 351 259758 18794 46407159
Stress urinary incontinence 172.57 10.20 121 259988 1995 46423958
Osteitis 166.95 10.20 140 259969 3045 46422908
Granuloma skin 166.53 10.20 145 259964 3325 46422628
Mitral valve prolapse 166.28 10.20 122 259987 2167 46423786
Intervertebral disc protrusion 165.32 10.20 357 259752 20048 46405905
Periprosthetic fracture 164.66 10.20 69 260040 365 46425588
Abscess 164.03 10.20 285 259824 13604 46412349
Cardiac murmur 161.58 10.20 254 259855 11150 46414803
Abscess jaw 159.56 10.20 100 260009 1352 46424601
Appendix disorder 158.55 10.20 95 260014 1179 46424774
Thrombocytopenia 156.97 10.20 291 259818 126290 46299663
Breast disorder 155.48 10.20 110 259999 1841 46424112
Hospitalisation 154.50 10.20 80 260029 63305 46362648
Appendicectomy 154.49 10.20 121 259988 2380 46423573
Cardio-respiratory arrest 154.40 10.20 70 260039 59799 46366154
Tendonitis 153.26 10.20 281 259828 13996 46411957
Fistula 152.23 10.20 205 259904 7805 46418148
Joint effusion 152.04 10.20 254 259855 11741 46414212
Fracture displacement 151.21 10.20 92 260017 1176 46424777
Panniculitis 150.27 10.20 172 259937 5532 46420421
Dental fistula 150.11 10.20 71 260038 522 46425431
Varicose vein 148.79 10.20 152 259957 4286 46421667
Arthritis 148.74 10.20 835 259274 76481 46349472
Atrophic vulvovaginitis 147.54 10.20 97 260012 1431 46424522
Seizure 147.24 10.20 289 259820 122765 46303188
Removal of internal fixation 145.89 10.20 42 260067 45 46425908
Hysterectomy 144.14 10.20 197 259912 7609 46418344
Asthenia 143.15 10.20 1080 259029 309995 46115958
Spinal fracture 143.04 10.20 284 259825 15021 46410932
Fracture 141.32 10.20 295 259814 16176 46409777
Oesophagitis 139.42 10.20 263 259846 13388 46412565
Dental necrosis 138.91 10.20 46 260063 105 46425848
Femoral neck fracture 138.43 10.20 197 259912 7906 46418047
Hyperaesthesia teeth 138.19 10.20 94 260015 1472 46424481
Exposed bone in jaw 136.02 10.20 125 259984 3083 46422870
Atypical fracture 135.73 10.20 65 260044 493 46425460
Platelet count decreased 134.89 10.20 218 259891 99806 46326147
Radiculopathy 134.17 10.20 152 259957 4833 46421120
Cystocele 133.85 10.20 83 260026 1100 46424853
Rheumatoid nodule 133.51 10.20 205 259904 8815 46417138
Rhinitis allergic 133.12 10.20 178 259931 6730 46419223
Dental implantation 131.97 10.20 65 260044 528 46425425
Injection site erythema 130.58 10.20 133 259976 74294 46351659
Foetal exposure during pregnancy 130.15 10.20 11 260098 30736 46395217
Pneumonia 126.95 10.20 1413 258696 374907 46051046
Respiratory arrest 125.87 10.20 19 260090 33797 46392156
Adverse drug reaction 125.46 10.20 535 259574 43827 46382126
Feeling abnormal 124.95 10.20 324 259785 124736 46301217
Seborrhoeic keratosis 124.87 10.20 95 260014 1787 46424166
Dyslipidaemia 124.42 10.20 154 259955 5386 46420567
Therapeutic product effect incomplete 123.61 10.20 152 259957 78001 46347952
Carpal tunnel syndrome 122.26 10.20 272 259837 15587 46410366
Fractured sacrum 121.76 10.20 93 260016 1760 46424193
Humerus fracture 120.66 10.20 178 259931 7384 46418569
Hypercalcaemia 120.62 10.20 322 259787 20724 46405229
Intentional product misuse 120.12 10.20 56 260053 47072 46378881
Psoriasis 120.03 10.20 157 259952 78447 46347506
Pain in jaw 119.73 10.20 477 259632 37895 46388058
Fatigue 119.70 10.20 2536 257573 606161 45819792
Oestrogen deficiency 119.69 10.20 42 260067 122 46425831
Foot deformity 119.41 10.20 265 259844 15160 46410793
Abdominal pain 119.30 10.20 771 259338 229260 46196693
Ankle fracture 117.30 10.20 264 259845 15247 46410706
Sepsis 117.17 10.20 378 259731 135636 46290317
Pulpitis dental 116.58 10.20 66 260043 731 46425222
Duodenal ulcer perforation 115.81 10.20 186 259923 8316 46417637
Urticaria 115.81 10.20 308 259801 117584 46308369
Compression fracture 115.67 10.20 158 259951 6099 46419854
Ulcer 115.14 10.20 281 259828 17111 46408842
Hand fracture 114.12 10.20 133 259976 4363 46421590
Loss of consciousness 112.32 10.20 275 259834 107963 46317990
Electrocardiogram QT prolonged 112.01 10.20 74 260035 51251 46374702
Essential hypertension 111.91 10.20 129 259980 4181 46421772
Somnolence 111.85 10.20 470 259639 156051 46269902
Endodontic procedure 111.58 10.20 100 260009 2385 46423568
Product use in unapproved indication 111.46 10.20 208 259901 90065 46335888
Decreased appetite 110.80 10.20 630 259479 193206 46232747
Hyperhidrosis 110.07 10.20 206 259903 89102 46336851
Gingival bleeding 110.00 10.20 217 259892 11422 46414531
Vertebral foraminal stenosis 109.88 10.20 66 260043 823 46425130
Patella fracture 108.97 10.20 88 260021 1812 46424141
Wrong technique in product usage process 108.93 10.20 86 260023 54336 46371617
Premature delivery 108.84 10.20 3 260106 22066 46403887
Jaw operation 108.69 10.20 63 260046 732 46425221
Sciatica 107.99 10.20 290 259819 18730 46407223
Depression 107.67 10.20 1433 258676 168671 46257282
Anaphylactic reaction 107.49 10.20 83 260026 53029 46372924
Peptic ulcer 107.06 10.20 121 259988 3837 46422116
Oral surgery 104.65 10.20 69 260040 1023 46424930
Condition aggravated 104.63 10.20 868 259241 244184 46181769
Spinal stenosis 104.53 10.20 222 259887 12321 46413632
Chronic obstructive pulmonary disease 103.99 10.20 612 259497 57021 46368932
Flushing 103.94 10.20 124 259985 64490 46361463
Swelling 103.00 10.20 1104 259005 123407 46302546
Abscess oral 102.82 10.20 76 260033 1366 46424587
Vascular calcification 102.24 10.20 58 260051 645 46425308
Periodontal operation 101.93 10.20 28 260081 21 46425932
Skin necrosis 100.87 10.20 176 259933 8428 46417525
Nasopharyngitis 100.06 10.20 479 259630 153519 46272434
Osteomyelitis chronic 99.68 10.20 48 260061 369 46425584
Discomfort 99.16 10.20 518 259591 46152 46379801
Gastritis 98.29 10.20 416 259693 33962 46391991
Lower limb fracture 98.24 10.20 215 259894 12183 46413770
Pancytopenia 98.09 10.20 204 259905 84854 46341099
Bone lesion 98.01 10.20 129 259980 4802 46421151
Rectocele 97.12 10.20 61 260048 828 46425125
General physical health deterioration 96.75 10.20 326 259783 115443 46310510
Gingival recession 96.53 10.20 70 260039 1220 46424733
Carotid bruit 96.20 10.20 57 260052 692 46425261
Dizziness 94.51 10.20 1332 258777 339082 46086871
Spinal disorder 93.90 10.20 164 259945 7860 46418093
Intentional self-injury 93.66 10.20 12 260097 24154 46401799
Iliotibial band syndrome 92.84 10.20 34 260075 116 46425837
Multiple organ dysfunction syndrome 92.30 10.20 91 260018 51619 46374334
Renal cyst 92.25 10.20 171 259938 8588 46417365
Leukopenia 91.14 10.20 150 259959 68193 46357760
Injection site swelling 90.93 10.20 56 260053 40271 46385682
Overdose 90.90 10.20 279 259830 101700 46324253
Aortic arteriosclerosis 88.89 10.20 133 259976 5588 46420365
Fracture malunion 88.11 10.20 34 260075 139 46425814
Oroantral fistula 87.62 10.20 35 260074 160 46425793
Drug reaction with eosinophilia and systemic symptoms 87.06 10.20 28 260081 29520 46396433
Spinal laminectomy 85.85 10.20 52 260057 659 46425294
Suicidal ideation 85.67 10.20 113 259996 56269 46369684
Agitation 85.30 10.20 110 259999 55305 46370648
Unevaluable event 85.05 10.20 79 260030 46096 46379857
Neoplasm progression 84.66 10.20 22 260087 26661 46399292
Bone metabolism disorder 84.12 10.20 40 260069 298 46425655
Neutrophil count decreased 83.95 10.20 71 260038 43355 46382598
Injection site reaction 83.35 10.20 86 260023 47763 46378190
Breast conserving surgery 83.23 10.20 53 260056 738 46425215
Acute sinusitis 82.72 10.20 106 260003 3841 46422112
Lumbosacral radiculopathy 81.78 10.20 38 260071 267 46425686
Peripheral vascular disorder 81.74 10.20 131 259978 5846 46420107
Road traffic accident 81.67 10.20 304 259805 23387 46402566
Tachycardia 81.56 10.20 283 259826 99339 46326614
Tremor 81.49 10.20 349 259760 115290 46310663
Nasal septum deviation 81.19 10.20 61 260048 1125 46424828
Contraindicated product administered 80.73 10.20 739 259370 79208 46346745
Toothache 80.51 10.20 239 259870 16353 46409600
Helicobacter infection 79.16 10.20 191 259918 11545 46414408
Rheumatoid factor positive 78.58 10.20 272 259837 20189 46405764
Intervertebral disc disorder 77.58 10.20 105 260004 4017 46421936
Emphysema 77.48 10.20 162 259947 8892 46417061
Acetabulum fracture 77.47 10.20 36 260073 253 46425700
Chills 77.14 10.20 275 259834 95757 46330196
Osteopetrosis 76.88 10.20 21 260088 15 46425938
Peripheral swelling 76.78 10.20 540 259569 157531 46268422
Diverticulum intestinal 76.66 10.20 128 259981 5913 46420040
Oesophageal ulcer 76.23 10.20 102 260007 3859 46422094
Oedema mouth 76.20 10.20 82 260027 2459 46423494
Bruxism 76.16 10.20 89 260020 2928 46423025
Closed fracture manipulation 75.86 10.20 20 260089 10 46425943
Tooth deposit 75.50 10.20 32 260077 175 46425778
Mucosal inflammation 75.01 10.20 64 260045 38912 46387041
Rash 74.93 10.20 1468 258641 355044 46070909
Hypertonic bladder 74.80 10.20 88 260021 2916 46423037
Skeletal injury 74.75 10.20 57 260052 1076 46424877
Dental plaque 74.73 10.20 26 260083 73 46425880
Trismus 74.62 10.20 95 260014 3420 46422533
Arthroscopy 74.39 10.20 47 260062 645 46425308
Abdominal pain upper 73.23 10.20 491 259618 144814 46281139
Biopsy bone 73.14 10.20 22 260087 31 46425922
Caesarean section 72.93 10.20 5 260104 16598 46409355
Actinomycosis 72.36 10.20 55 260054 1033 46424920
Nocturia 72.32 10.20 137 259972 6995 46418958
Osteoradionecrosis 72.01 10.20 29 260080 136 46425817
Metabolic acidosis 71.83 10.20 66 260043 38714 46387239
Acquired oesophageal web 71.72 10.20 32 260077 202 46425751
Depressed level of consciousness 71.60 10.20 96 260013 47473 46378480
Jaw cyst 71.42 10.20 27 260082 103 46425850
Drug resistance 71.40 10.20 7 260102 17361 46408592
Upper limb fracture 71.23 10.20 221 259888 15492 46410461
Hyperparathyroidism 70.85 10.20 78 260031 2401 46423552
Drug withdrawal syndrome 70.62 10.20 32 260077 27352 46398601
Blood creatinine increased 70.25 10.20 206 259903 76197 46349756
COVID-19 70.14 10.20 10 260099 18565 46407388
Septic shock 70.03 10.20 135 259974 57758 46368195
Weight increased 69.93 10.20 583 259526 163890 46262063
Plantar fasciitis 69.74 10.20 81 260028 2647 46423306
Lumbar vertebral fracture 69.73 10.20 105 260004 4437 46421516
Multiple sclerosis relapse 69.73 10.20 79 260030 42046 46383907
Carotid artery stenosis 69.72 10.20 112 259997 5008 46420945
Sopor 69.67 10.20 13 260096 19815 46406138
Bunion operation 69.57 10.20 48 260061 770 46425183
Thoracic vertebral fracture 69.50 10.20 99 260010 3976 46421977
Type 2 diabetes mellitus 69.32 10.20 256 259853 19619 46406334
Dehydration 68.97 10.20 563 259546 158977 46266976
Type V hyperlipidaemia 68.93 10.20 38 260071 398 46425555
Plasma cell myeloma 68.75 10.20 88 260021 44390 46381563
Pulmonary embolism 68.61 10.20 341 259768 108244 46317709
Cholecystectomy 68.48 10.20 154 259955 8888 46417065
Actinic keratosis 68.46 10.20 73 260036 2166 46423787
Urinary bladder suspension 68.22 10.20 34 260075 284 46425669
Urge incontinence 68.13 10.20 46 260063 711 46425242
Arthralgia 68.06 10.20 2577 257532 362026 46063927
Coronary artery disease 67.85 10.20 369 259740 33383 46392570
Accidental exposure to product 67.61 10.20 17 260092 21064 46404889
Anaemia of chronic disease 67.58 10.20 68 260041 1882 46424071
Tooth infection 67.41 10.20 185 259924 12101 46413852
Lactic acidosis 67.33 10.20 54 260055 33855 46392098
Breast calcifications 67.31 10.20 54 260055 1101 46424852
Bone formation decreased 66.26 10.20 23 260086 64 46425889
Bone fragmentation 66.24 10.20 45 260064 703 46425250
Weight decreased 66.12 10.20 804 259305 210045 46215908
Eustachian tube dysfunction 65.80 10.20 36 260073 371 46425582
Tenosynovitis stenosans 65.79 10.20 67 260042 1882 46424071
Sinus disorder 65.20 10.20 222 259887 16341 46409612
Cough 64.84 10.20 898 259211 229351 46196602
Pernicious anaemia 64.17 10.20 43 260066 656 46425297
Hepatic failure 64.14 10.20 55 260054 33361 46392592
Body height decreased 63.94 10.20 156 259953 9496 46416457
Hepatocellular injury 63.82 10.20 43 260066 29479 46396474
Encephalopathy 63.61 10.20 56 260053 33533 46392420
Renal failure 63.34 10.20 372 259737 113222 46312731
Product quality issue 63.31 10.20 63 260046 35585 46390368
Injection site bruising 63.26 10.20 63 260046 35573 46390380
Angiopathy 63.25 10.20 97 260012 4166 46421787
Injection site pruritus 63.13 10.20 77 260032 39666 46386287
Arteriosclerosis coronary artery 62.99 10.20 140 259969 8016 46417937
Tendon disorder 62.27 10.20 105 260004 4890 46421063
Skin cancer 62.11 10.20 146 259963 8677 46417276
Respiratory failure 62.08 10.20 294 259815 94522 46331431
Intraocular lens implant 61.93 10.20 30 260079 234 46425719
Pain in extremity 61.53 10.20 1881 258228 256799 46169154
Skin discolouration 61.27 10.20 55 260054 32625 46393328
Atrophy 61.01 10.20 58 260051 1495 46424458
Back disorder 60.83 10.20 148 259961 8993 46416960
Osteosclerosis 60.82 10.20 86 260023 3430 46422523
Osteoma 60.77 10.20 19 260090 33 46425920
Pregnancy 60.74 10.20 38 260071 27099 46398854
Irritable bowel syndrome 60.37 10.20 216 259893 16299 46409654
Gingival pain 60.37 10.20 116 259993 5987 46419966
Perineurial cyst 60.14 10.20 17 260092 16 46425937
Postmenopause 60.07 10.20 19 260090 35 46425918
Influenza like illness 59.90 10.20 146 259963 57424 46368529
Kyphoscoliosis 59.42 10.20 35 260074 420 46425533
Mastication disorder 59.18 10.20 64 260045 1930 46424023
Oxygen saturation decreased 58.97 10.20 193 259916 68971 46356982
Feeling hot 58.66 10.20 75 260034 37853 46388100
Bladder disorder 58.66 10.20 125 259984 6953 46419000
Colon adenoma 58.54 10.20 56 260053 1455 46424498
Cardiac failure 58.34 10.20 238 259871 79710 46346243
Generalised tonic-clonic seizure 57.97 10.20 40 260069 27082 46398871
Depressed mood 57.90 10.20 60 260049 33259 46392694
Lung neoplasm 57.88 10.20 110 259999 5630 46420323
Renal impairment 57.72 10.20 216 259893 74156 46351797
Adenotonsillectomy 57.53 10.20 20 260089 56 46425897
Posterior reversible encephalopathy syndrome 57.52 10.20 8 260101 15133 46410820
Adenoidal disorder 57.48 10.20 21 260088 71 46425882
Bone sequestrum 57.36 10.20 58 260051 1615 46424338
Cholestasis 57.03 10.20 40 260069 26853 46399100
Joint dislocation 57.02 10.20 164 259945 11022 46414931
Steroid therapy 57.02 10.20 20 260089 58 46425895
Iron deficiency anaemia 57.00 10.20 218 259891 16988 46408965
Osteomalacia 56.94 10.20 39 260070 618 46425335
Anaphylactic shock 56.64 10.20 21 260088 20253 46405700
Carotid artery disease 56.55 10.20 58 260051 1643 46424310
Purulence 56.10 10.20 56 260053 1535 46424418
Drug hypersensitivity 55.80 10.20 989 259120 242836 46183117
Polymyalgia rheumatica 55.67 10.20 67 260042 2275 46423678
Haemoglobin decreased 54.82 10.20 457 259652 128492 46297461
Bladder repair 54.70 10.20 19 260090 53 46425900
Drug tolerance decreased 54.67 10.20 76 260033 2983 46422970
Diabetic ketoacidosis 54.10 10.20 17 260092 18193 46407760
Multiple fractures 54.07 10.20 105 260004 5462 46420491
Chronic sinusitis 53.93 10.20 99 260010 4934 46421019
Confusional state 53.86 10.20 600 259509 159292 46266661
Goitre 53.56 10.20 102 260007 5229 46420724
Postmenopausal haemorrhage 53.53 10.20 61 260048 1952 46424001
Biopsy breast 52.86 10.20 28 260081 269 46425684
Blood glucose increased 52.78 10.20 214 259895 71799 46354154
Restlessness 52.77 10.20 39 260070 25485 46400468
Erythema 52.54 10.20 525 259584 142295 46283658
Thyroid neoplasm 52.36 10.20 82 260027 3587 46422366
Scapula fracture 52.34 10.20 31 260078 376 46425577
Debridement 52.24 10.20 50 260059 1300 46424653
Bone marrow failure 52.04 10.20 53 260056 29616 46396337
Ascites 51.90 10.20 77 260032 36507 46389446
Sjogren's syndrome 51.74 10.20 45 260064 1030 46424923
Toxic epidermal necrolysis 51.54 10.20 30 260079 22248 46403705
Meniscus removal 51.46 10.20 16 260093 27 46425926
Oesophageal stenosis 51.24 10.20 71 260038 2778 46423175
Malocclusion 51.04 10.20 20 260089 86 46425867
Rash maculo-papular 50.96 10.20 48 260061 27826 46398127
Skin laceration 50.65 10.20 221 259888 18281 46407672
Comminuted fracture 50.61 10.20 34 260075 521 46425432
Rheumatoid arthritis 50.41 10.20 1721 258388 238494 46187459
Oral fibroma 50.41 10.20 17 260092 42 46425911
Alveolar osteitis 50.33 10.20 28 260081 299 46425654
Disturbance in attention 50.28 10.20 61 260048 31499 46394454
Groin pain 50.23 10.20 137 259972 8928 46417025
Onychomycosis 50.20 10.20 86 260023 4057 46421896
Sequestrectomy 50.17 10.20 44 260065 1019 46424934
Osteogenesis imperfecta 50.10 10.20 29 260080 336 46425617
Serotonin syndrome 50.08 10.20 37 260072 24183 46401770
Sedation 50.02 10.20 33 260076 22877 46403076
Knee deformity 49.97 10.20 39 260070 763 46425190
Fluid retention 49.60 10.20 134 259975 50912 46375041
No adverse event 49.59 10.20 71 260038 34160 46391793
Hepatotoxicity 49.44 10.20 40 260069 24969 46400984
Joint injury 49.24 10.20 225 259884 18984 46406969
Abnormal behaviour 49.22 10.20 28 260081 21030 46404923
Arteriosclerosis 48.94 10.20 142 259967 9591 46416362
Glaucoma 48.91 10.20 197 259912 15724 46410229
Influenza 48.88 10.20 294 259815 88976 46336977
Dental prosthesis placement 48.80 10.20 18 260091 63 46425890
Limb injury 48.71 10.20 224 259885 18950 46407003
Anxiety 48.67 10.20 1343 258766 180614 46245339
Scleritis 48.57 10.20 70 260039 2842 46423111
Dermal cyst 48.52 10.20 52 260057 1552 46424401
Dysarthria 48.41 10.20 84 260025 37414 46388539
Oesophageal carcinoma 48.41 10.20 39 260070 800 46425153
Oophorectomy 48.17 10.20 31 260078 440 46425513
Varicose vein operation 48.16 10.20 14 260095 16 46425937
Atelectasis 48.10 10.20 220 259889 18570 46407383
Spinal fusion surgery 47.95 10.20 70 260039 2876 46423077
Trigger finger 47.84 10.20 76 260033 3366 46422587
Peripheral venous disease 47.76 10.20 84 260025 4048 46421905
Facet joint syndrome 47.68 10.20 46 260063 1208 46424745
Post procedural fever 47.66 10.20 25 260084 235 46425718
Breast cyst 47.56 10.20 50 260059 1459 46424494
Burning sensation 47.49 10.20 111 259998 44300 46381653
Back pain 47.44 10.20 1518 258591 208521 46217432
Poisoning 47.44 10.20 10 260099 13984 46411969
Therapy cessation 47.36 10.20 47 260062 26582 46399371
Clostridium difficile infection 47.35 10.20 42 260067 25061 46400892
Osteomyelitis acute 47.20 10.20 23 260086 182 46425771
Therapy non-responder 47.17 10.20 99 260010 41053 46384900
Heart rate increased 47.16 10.20 235 259874 74556 46351397
Periostitis 47.12 10.20 24 260085 211 46425742
Skin ulcer 46.99 10.20 326 259783 32132 46393821
Impaired fasting glucose 46.94 10.20 22 260087 158 46425795
Macular degeneration 46.19 10.20 115 259994 7090 46418863
Vitamin B12 deficiency 46.13 10.20 81 260028 3898 46422055
Device issue 46.08 10.20 27 260082 19953 46406000
Fluid overload 46.07 10.20 50 260059 27135 46398818
Oesophageal disorder 45.92 10.20 58 260051 2071 46423882
Skin abrasion 45.76 10.20 127 259982 8361 46417592
Increased tendency to bruise 45.51 10.20 136 259973 9338 46416615
Incorrect dose administered 45.45 10.20 118 259991 45432 46380521
Anxiety disorder 45.36 10.20 75 260034 3436 46422517
Epicondylitis 44.99 10.20 52 260057 1690 46424263
Dyskinesia 44.93 10.20 57 260052 28868 46397085
Melanocytic naevus 44.93 10.20 79 260030 3806 46422147
Cerebral small vessel ischaemic disease 44.92 10.20 35 260074 683 46425270
Carpal tunnel decompression 44.85 10.20 37 260072 786 46425167
Intermittent claudication 44.80 10.20 53 260056 1767 46424186
Synovitis 44.76 10.20 529 259580 60546 46365407
Cognitive disorder 44.61 10.20 86 260023 36797 46389156
Periarthritis 44.55 10.20 55 260054 1918 46424035
Barrett's oesophagus 44.49 10.20 34 260075 644 46425309
Rash erythematous 44.30 10.20 77 260032 34273 46391680
Neurotoxicity 44.11 10.20 11 260098 13706 46412247
Cyst 44.00 10.20 158 259951 11942 46414011
Irritability 43.98 10.20 58 260051 28888 46397065
Pulmonary oedema 43.98 10.20 142 259967 50963 46374990
Spondylolysis 43.94 10.20 15 260094 39 46425914
Uterine prolapse 43.79 10.20 42 260067 1095 46424858
Phlebolith 43.77 10.20 21 260088 160 46425793
Blood bilirubin increased 43.75 10.20 77 260032 34107 46391846
Hair follicle tumour benign 43.72 10.20 27 260082 355 46425598
Ovarian disorder 43.57 10.20 34 260075 665 46425288
Memory impairment 43.23 10.20 253 259856 77084 46348869
Glucose tolerance impaired 43.17 10.20 88 260021 4743 46421210
Angioedema 43.14 10.20 97 260012 39245 46386708
Salpingo-oophorectomy bilateral 43.11 10.20 20 260089 140 46425813
Hypercalciuria 43.01 10.20 21 260088 167 46425786
Altered state of consciousness 42.93 10.20 40 260069 23308 46402645
Radiotherapy 42.87 10.20 25 260084 294 46425659
Breast mass 42.66 10.20 102 260007 6129 46419824
Palmar-plantar erythrodysaesthesia syndrome 42.60 10.20 31 260078 20420 46405533
Withdrawal syndrome 42.55 10.20 24 260085 18110 46407843
Bradycardia 41.98 10.20 208 259901 66090 46359863
Mobility decreased 41.97 10.20 184 259925 60410 46365543
Chondrocalcinosis 41.95 10.20 30 260079 511 46425442
Gingival abscess 41.88 10.20 32 260077 606 46425347
Blood pressure increased 41.59 10.20 478 259631 126188 46299765
Left ventricular hypertrophy 41.53 10.20 88 260021 4875 46421078
Incisional drainage 41.26 10.20 29 260080 480 46425473
Abdominal distension 40.98 10.20 240 259869 73111 46352842
Ilium fracture 40.80 10.20 16 260093 69 46425884
Therapy interrupted 40.30 10.20 6 260103 10785 46415168
Psychotic disorder 40.14 10.20 40 260069 22581 46403372
Blood pressure decreased 39.93 10.20 173 259936 56986 46368967
Status epilepticus 39.87 10.20 14 260095 13965 46411988
Unresponsive to stimuli 39.81 10.20 74 260035 32100 46393853
Transaminases increased 39.80 10.20 58 260051 27703 46398250
Cytomegalovirus infection 39.79 10.20 26 260083 18118 46407835
Acrochordon 39.78 10.20 35 260074 814 46425139
Dermal sinus 39.77 10.20 13 260096 28 46425925
Shock 39.49 10.20 38 260071 21807 46404146
Extraskeletal ossification 39.32 10.20 14 260095 43 46425910
Benign neoplasm of skin 39.14 10.20 19 260090 149 46425804
Crying 39.13 10.20 36 260073 21105 46404848
Sacroiliitis 38.93 10.20 54 260055 2115 46423838
Disorientation 38.89 10.20 93 260016 36825 46389128
Post procedural constipation 38.75 10.20 16 260093 81 46425872
Restless legs syndrome 38.71 10.20 183 259926 15660 46410293
Jaw fistula 38.62 10.20 14 260095 46 46425907
Hormone therapy 38.61 10.20 10 260099 4 46425949
Mammogram abnormal 38.61 10.20 30 260079 583 46425370
Drug ineffective for unapproved indication 38.11 10.20 22 260087 16391 46409562
Bone marrow oedema 38.07 10.20 34 260075 807 46425146
Mitral valve incompetence 37.82 10.20 206 259903 18646 46407307
Rotator cuff repair 37.76 10.20 44 260065 1443 46424510
Sleep apnoea syndrome 37.63 10.20 232 259877 21969 46403984
Traumatic ulcer 37.50 10.20 13 260096 36 46425917
Traumatic fracture 37.42 10.20 28 260081 513 46425440
Tooth impacted 37.37 10.20 17 260092 113 46425840
Pulmonary arterial hypertension 37.34 10.20 54 260055 25874 46400079
External fixation of fracture 37.29 10.20 10 260099 6 46425947
Vaginal haemorrhage 37.19 10.20 53 260056 25551 46400402
Cervicobrachial syndrome 37.07 10.20 35 260074 894 46425059
Neuritis 36.92 10.20 32 260077 729 46425224
Infusion site pain 36.88 10.20 6 260103 10101 46415852
Rectal polyp 36.72 10.20 33 260076 790 46425163
Gingival swelling 36.55 10.20 73 260036 3877 46422076
Therapeutic response decreased 36.35 10.20 121 259988 43024 46382929
Dental prosthesis user 36.14 10.20 14 260095 58 46425895
Red blood cell count decreased 36.13 10.20 80 260029 32543 46393410
Sialoadenitis 36.11 10.20 40 260069 1240 46424713
Bone formation increased 36.09 10.20 19 260090 180 46425773
Chest discomfort 36.09 10.20 325 259784 89944 46336009
Cervical spinal stenosis 35.97 10.20 49 260060 1886 46424067
Paraesthesia 35.56 10.20 451 259658 116986 46308967
Neuroma 35.49 10.20 24 260085 372 46425581
Myositis ossificans 35.19 10.20 9 260100 3 46425950
Senile osteoporosis 35.17 10.20 18 260091 160 46425793
Injection site mass 35.15 10.20 20 260089 15020 46410933
Aggression 35.14 10.20 45 260064 22699 46403254
Bone fistula 35.10 10.20 15 260094 84 46425869
Post laminectomy syndrome 35.06 10.20 20 260089 225 46425728
Mydriasis 34.84 10.20 8 260101 10545 46415408
Myofascial pain syndrome 34.74 10.20 48 260061 1873 46424080
Morton's neuralgia 34.71 10.20 14 260095 66 46425887
Pallor 34.60 10.20 47 260062 23119 46402834
Neurectomy 34.47 10.20 9 260100 4 46425949
Gastric ulcer 34.29 10.20 224 259885 21639 46404314
Acute respiratory distress syndrome 34.26 10.20 43 260066 21879 46404074
Oropharyngeal pain 34.22 10.20 257 259852 73911 46352042
Epistaxis 34.03 10.20 214 259895 64091 46361862
Acute hepatic failure 33.80 10.20 20 260089 14701 46411252
Vertigo positional 33.74 10.20 56 260053 2574 46423379
Vaginal disorder 33.70 10.20 29 260080 654 46425299
Vertebroplasty 33.67 10.20 22 260087 321 46425632
Pancreatitis 33.65 10.20 127 259982 43500 46382453
Epilepsy 33.63 10.20 50 260059 23688 46402265
Liver function test increased 33.40 10.20 47 260062 22779 46403174
Hypothermia 33.40 10.20 13 260096 12170 46413783
Mood swings 33.38 10.20 25 260084 16227 46409726
Full blood count decreased 33.24 10.20 45 260064 22166 46403787
Uterine leiomyoma 33.15 10.20 110 259999 7989 46417964
Clavicle fracture 33.15 10.20 59 260050 2870 46423083
Hyperkeratosis 33.05 10.20 81 260028 4944 46421009
Leukoplakia 32.82 10.20 14 260095 78 46425875
Hyperparathyroidism primary 32.75 10.20 22 260087 337 46425616
Drug eruption 32.52 10.20 217 259892 21112 46404841
Stasis dermatitis 32.48 10.20 28 260081 633 46425320
Injection site urticaria 32.43 10.20 13 260096 11954 46413999
Drug level increased 32.27 10.20 33 260076 18408 46407545
Pericardial effusion 32.27 10.20 58 260051 25485 46400468
Haemorrhoid operation 32.26 10.20 22 260087 346 46425607
Face injury 32.04 10.20 56 260053 2685 46423268
Akathisia 32.00 10.20 3 260106 7711 46418242
Illness 31.96 10.20 14 260095 12210 46413743
Lipoma 31.95 10.20 48 260061 2024 46423929
Avulsion fracture 31.94 10.20 20 260089 270 46425683
Oesophageal perforation 31.83 10.20 19 260090 234 46425719
Body temperature increased 31.81 10.20 56 260053 24805 46401148
Accidental overdose 31.74 10.20 39 260070 20027 46405926
Dental alveolar anomaly 31.61 10.20 13 260096 65 46425888
Respiratory distress 31.60 10.20 83 260026 31833 46394120
Abortion induced 31.53 10.20 9 260100 10251 46415702
Lymphocyte count decreased 31.53 10.20 59 260050 25530 46400423
Schizophrenia 31.46 10.20 5 260104 8563 46417390
Joint arthroplasty 31.32 10.20 47 260062 1980 46423973
Injection site warmth 31.22 10.20 19 260090 13753 46412200
Gingivectomy 31.04 10.20 8 260101 3 46425950
Neutropenic sepsis 30.85 10.20 15 260094 12309 46413644
Vulvovaginal dryness 30.75 10.20 49 260060 2176 46423777
Radicular pain 30.67 10.20 23 260086 423 46425530
Swollen joint count increased 30.65 10.20 51 260058 2349 46423604
Rheumatic fever 30.56 10.20 56 260053 2787 46423166
Rhinorrhoea 30.48 10.20 149 259960 47516 46378437
Laryngeal ulceration 30.34 10.20 8 260101 4 46425949
Aortic stenosis 30.29 10.20 72 260037 4310 46421643
Hepatitis 30.23 10.20 86 260023 32129 46393824
Agranulocytosis 30.21 10.20 48 260061 22137 46403816
Chondromalacia 30.13 10.20 20 260089 300 46425653
Poor dental condition 30.08 10.20 20 260089 301 46425652
Pleural effusion 30.04 10.20 306 259803 82646 46343307
Forearm fracture 30.03 10.20 23 260086 437 46425516
Uterine dilation and curettage 30.00 10.20 31 260078 886 46425067
Haematemesis 29.93 10.20 268 259841 28538 46397415
Trigeminal neuralgia 29.79 10.20 57 260052 2932 46423021
Peritonitis bacterial 29.71 10.20 6 260103 8647 46417306
Toxic skin eruption 29.63 10.20 16 260093 12371 46413582
Thrombosis 29.46 10.20 187 259922 55882 46370071
Gestational diabetes 29.44 10.20 3 260106 7216 46418737
Gastric ulcer haemorrhage 29.44 10.20 76 260033 4792 46421161
Benign breast lump removal 29.37 10.20 7 260102 0 46425953
Infusion related reaction 29.32 10.20 755 259354 100453 46325500
Oesophageal discomfort 29.32 10.20 16 260093 164 46425789
Incision site cellulitis 29.28 10.20 13 260096 81 46425872
Rhinoplasty 29.12 10.20 8 260101 6 46425947
Oral pain 29.08 10.20 237 259872 24560 46401393
Cardiogenic shock 29.04 10.20 29 260080 16355 46409598
Enterocele 29.02 10.20 12 260097 61 46425892
Urethral caruncle 29.01 10.20 13 260096 83 46425870
Infective pulmonary exacerbation of cystic fibrosis 28.86 10.20 12 260097 10795 46415158
Dry skin 28.73 10.20 124 259985 40892 46385061
Leukoplakia oral 28.71 10.20 14 260095 111 46425842
Rhabdomyolysis 28.57 10.20 128 259981 41781 46384172
Blood glucose decreased 28.55 10.20 38 260071 18854 46407099
Bone atrophy 28.51 10.20 10 260099 29 46425924
Transplant rejection 28.43 10.20 9 260100 9587 46416366
Therapeutic response unexpected 28.42 10.20 27 260082 15589 46410364
Lacrimation increased 28.20 10.20 28 260081 15833 46410120
Meralgia paraesthetica 28.19 10.20 14 260095 116 46425837
Renal injury 28.18 10.20 9 260100 9532 46416421
Disease recurrence 28.07 10.20 37 260072 18434 46407519
Hormone level abnormal 28.07 10.20 46 260063 2092 46423861
Cataract nuclear 28.06 10.20 29 260080 829 46425124
Device dislocation 28.00 10.20 49 260060 21753 46404200
Haematotoxicity 27.96 10.20 3 260106 6930 46419023
Metatarsalgia 27.82 10.20 16 260093 183 46425770
Lethargy 27.75 10.20 169 259940 51002 46374951
Hyperkalaemia 27.75 10.20 167 259942 50542 46375411
Fibroadenoma of breast 27.66 10.20 20 260089 347 46425606
Joint dislocation reduction 27.59 10.20 8 260101 9 46425944
Raynaud's phenomenon 27.38 10.20 35 260074 1265 46424688
Colitis 27.35 10.20 111 259998 37236 46388717
Rhinitis perennial 27.34 10.20 9 260100 20 46425933
Synovial fluid analysis 27.29 10.20 36 260073 1343 46424610
Hyperbilirubinaemia 27.22 10.20 12 260097 10426 46415527
Neuroleptic malignant syndrome 27.15 10.20 14 260095 11108 46414845
Product storage error 27.10 10.20 16 260093 11776 46414177
Myoclonus 27.08 10.20 24 260085 14328 46411625
Anuria 27.00 10.20 15 260094 11416 46414537
Urine calcium increased 26.91 10.20 11 260098 54 46425899
Urinary incontinence 26.91 10.20 260 259849 28270 46397683
Oophorectomy bilateral 26.90 10.20 10 260099 36 46425917
Adenoidectomy 26.88 10.20 13 260096 101 46425852
Cervical polyp 26.88 10.20 16 260093 196 46425757
Benign neoplasm 26.83 10.20 29 260080 874 46425079
Haemorrhage 26.82 10.20 187 259922 54682 46371271
Stevens-Johnson syndrome 26.73 10.20 56 260053 23241 46402712
Osteitis deformans 26.49 10.20 17 260092 240 46425713
Otitis media 26.47 10.20 67 260042 4173 46421780
Tenosynovitis 26.37 10.20 97 260012 7418 46418535
Reflux laryngitis 26.35 10.20 12 260097 80 46425873
Respiratory depression 26.30 10.20 16 260093 11584 46414369
Cerebrovascular disorder 26.20 10.20 53 260056 2841 46423112
Grief reaction 26.13 10.20 16 260093 207 46425746
Skin exfoliation 25.98 10.20 95 260014 32843 46393110
Malpositioned teeth 25.92 10.20 8 260101 13 46425940
Immunodeficiency 25.85 10.20 21 260088 13085 46412868
Injection site rash 25.79 10.20 30 260079 15783 46410170
Dupuytren's contracture 25.74 10.20 12 260097 85 46425868
Dysgeusia 25.65 10.20 127 259982 40364 46385589
Mixed incontinence 25.63 10.20 12 260097 86 46425867
Nasal disorder 25.58 10.20 45 260064 2169 46423784
Bone pain 25.57 10.20 385 259724 46505 46379448
Cytopenia 25.43 10.20 6 260103 7762 46418191
Incision site haematoma 25.39 10.20 11 260098 64 46425889
Enchondromatosis 25.39 10.20 11 260098 64 46425889
C-reactive protein abnormal 25.37 10.20 50 260059 21220 46404733
Foreign body 25.30 10.20 41 260068 1847 46424106
Oesophageal ulcer haemorrhage 25.29 10.20 20 260089 399 46425554
Blood 25-hydroxycholecalciferol decreased 25.28 10.20 12 260097 89 46425864
Presbyopia 25.22 10.20 21 260088 452 46425501
Radiotherapy to breast 25.17 10.20 6 260103 0 46425953
Tendon sheath lesion excision 25.17 10.20 6 260103 0 46425953
Musculoskeletal discomfort 25.17 10.20 149 259960 13907 46412046
Lip neoplasm 25.07 10.20 7 260102 6 46425947
Mycotic allergy 24.89 10.20 22 260087 515 46425438
Tumour lysis syndrome 24.88 10.20 5 260104 7231 46418722
Oral discharge 24.73 10.20 14 260095 155 46425798
Metastases to central nervous system 24.72 10.20 16 260093 11205 46414748
Heart rate decreased 24.69 10.20 92 260017 31631 46394322
Oliguria 24.59 10.20 9 260100 8750 46417203
Torsade de pointes 24.57 10.20 19 260090 12135 46413818
Fracture reduction 24.56 10.20 7 260102 7 46425946
Nasal congestion 24.50 10.20 162 259947 47951 46378002
Bone scan abnormal 24.47 10.20 20 260089 419 46425534
Nightmare 24.46 10.20 34 260075 16564 46409389
Cytokine release syndrome 24.33 10.20 3 260106 6220 46419733
Intervertebral disc space narrowing 24.30 10.20 27 260082 840 46425113
Dialysis 24.30 10.20 13 260096 10103 46415850
Rosacea 24.28 10.20 57 260052 3384 46422569
Contusion 24.28 10.20 649 259460 86838 46339115
Hypertensive heart disease 24.28 10.20 48 260061 2530 46423423
Mood altered 24.25 10.20 22 260087 12985 46412968
Bronchitis chronic 24.12 10.20 64 260045 4103 46421850
Bone infarction 24.11 10.20 16 260093 240 46425713
Gamma-glutamyltransferase increased 24.09 10.20 93 260016 31647 46394306
Otitis externa 24.01 10.20 37 260072 1596 46424357
Musculoskeletal pain 23.90 10.20 535 259574 69593 46356360
Second primary malignancy 23.82 10.20 4 260105 6580 46419373
Palatal disorder 23.80 10.20 17 260092 289 46425664
Foot operation 23.71 10.20 69 260040 4668 46421285
Granuloma 23.70 10.20 60 260049 3738 46422215
Splenic granuloma 23.63 10.20 7 260102 9 46425944
Acne 23.60 10.20 47 260062 19872 46406081
Neuropathy peripheral 23.60 10.20 360 259749 90533 46335420
Dystonia 23.53 10.20 17 260092 11240 46414713
Inguinal hernia repair 23.48 10.20 9 260100 36 46425917
Hypophagia 23.46 10.20 84 260025 29222 46396731
Aphasia 23.46 10.20 81 260028 28486 46397467
Postoperative heterotopic calcification 23.38 10.20 8 260101 21 46425932
Dementia Alzheimer's type 23.34 10.20 31 260078 1164 46424789
Sinus tarsi syndrome 23.21 10.20 7 260102 10 46425943
Rash macular 23.21 10.20 45 260064 19215 46406738
Enthesopathy 23.17 10.20 68 260041 4622 46421331
Facial bones fracture 22.91 10.20 55 260054 3313 46422640
Drug-induced liver injury 22.87 10.20 69 260040 25299 46400654
Device difficult to use 22.85 10.20 8 260101 7996 46417957
Osteorrhagia 22.76 10.20 6 260103 3 46425950
Traumatic occlusion 22.76 10.20 6 260103 3 46425950
Right ventricular failure 22.70 10.20 34 260075 16059 46409894
Benign bone neoplasm 22.56 10.20 9 260100 41 46425912
Thrombotic microangiopathy 22.54 10.20 9 260100 8297 46417656
Cervical radiculopathy 22.50 10.20 26 260083 845 46425108
Tardive dyskinesia 22.48 10.20 7 260102 7536 46418417
X-ray of pelvis and hip abnormal 22.45 10.20 7 260102 12 46425941
Hip deformity 22.33 10.20 12 260097 119 46425834
Muscle rigidity 22.22 10.20 14 260095 9947 46416006
Brain oedema 22.21 10.20 22 260087 12456 46413497
Lower respiratory tract infection 22.16 10.20 198 259911 54891 46371062
Joint surgery 22.16 10.20 17 260092 324 46425629
Dental pulp disorder 22.09 10.20 7 260102 13 46425940
Miosis 22.07 10.20 5 260104 6652 46419301
Abdominal hernia 22.06 10.20 67 260042 4641 46421312
Tooth resorption 22.05 10.20 9 260100 44 46425909
Cellulitis 22.03 10.20 530 259579 69758 46356195
Amenorrhoea 22.00 10.20 11 260098 8884 46417069
Intentional product use issue 21.98 10.20 188 259921 52592 46373361
Product dispensing error 21.98 10.20 12 260097 9221 46416732
Purulent discharge 21.95 10.20 68 260041 4762 46421191
Lacunar infarction 21.69 10.20 55 260054 3430 46422523
Hepatic encephalopathy 21.68 10.20 15 260094 10142 46415811
Genital haemorrhage 21.63 10.20 5 260104 6561 46419392
Lenticular opacities 21.62 10.20 14 260095 201 46425752
Acute myeloid leukaemia 21.62 10.20 34 260075 15744 46410209
Erosive oesophagitis 21.57 10.20 36 260073 1662 46424291
Bone cyst 21.54 10.20 40 260069 2011 46423942
Ejection fraction decreased 21.53 10.20 42 260067 17895 46408058
Parathyroidectomy 21.51 10.20 15 260094 245 46425708
Spinal claudication 21.48 10.20 8 260101 29 46425924
Blood lactic acid increased 21.46 10.20 3 260106 5654 46420299
Ear disorder 21.45 10.20 51 260058 3053 46422900
Osteoporotic fracture 21.45 10.20 50 260059 2955 46422998
Cataract cortical 21.42 10.20 9 260100 48 46425905
Oesophageal injury 21.27 10.20 8 260101 30 46425923
Bladder prolapse 21.24 10.20 38 260071 1856 46424097
Hypoparathyroidism 21.23 10.20 22 260087 631 46425322
Wound drainage 21.16 10.20 25 260084 832 46425121
Bundle branch block left 21.13 10.20 81 260028 6318 46419635
Traumatic arthritis 21.07 10.20 8 260101 31 46425922
Aortic aneurysm 21.06 10.20 54 260055 3390 46422563
Actinic elastosis 21.05 10.20 6 260103 6 46425947
Pulmonary granuloma 21.03 10.20 31 260078 1285 46424668
Mental impairment 21.00 10.20 23 260086 12433 46413520
Apicectomy 20.98 10.20 5 260104 0 46425953
Tympanosclerosis 20.98 10.20 5 260104 0 46425953
Impacted fracture 20.98 10.20 5 260104 0 46425953
Chondroplasty 20.98 10.20 5 260104 0 46425953
Gastrooesophageal cancer 20.98 10.20 5 260104 0 46425953
Fibrous dysplasia of bone 20.98 10.20 5 260104 0 46425953
Benign breast neoplasm 20.94 10.20 29 260080 1134 46424819
Vision blurred 20.93 10.20 315 259794 79393 46346560
Persistent depressive disorder 20.93 10.20 27 260082 985 46424968
Inflammation 20.88 10.20 385 259724 48396 46377557
Odontogenic cyst 20.87 10.20 8 260101 32 46425921
Costochondritis 20.85 10.20 40 260069 2062 46423891
Bone sarcoma 20.84 10.20 7 260102 17 46425936
Circulatory collapse 20.83 10.20 57 260052 21567 46404386
Maternal drugs affecting foetus 20.76 10.20 3 260106 5515 46420438
Product prescribing error 20.72 10.20 51 260058 19996 46405957
Hypoglycaemia 20.71 10.20 198 259911 54151 46371802
Skin graft 20.71 10.20 20 260089 526 46425427
Intestinal obstruction 20.70 10.20 75 260034 26000 46399953
Bursa disorder 20.65 10.20 11 260098 107 46425846
Parathyroid disorder 20.58 10.20 20 260089 530 46425423
Multiple sclerosis 20.56 10.20 70 260039 24721 46401232
Throat irritation 20.47 10.20 87 260022 28814 46397139
Face oedema 20.37 10.20 48 260061 19105 46406848
Sight disability 20.30 10.20 11 260098 111 46425842
Squamous cell carcinoma 20.24 10.20 92 260017 7744 46418209
Thermohypoaesthesia 20.22 10.20 11 260098 112 46425841
Ischaemic stroke 20.21 10.20 39 260070 16683 46409270
Coccydynia 20.20 10.20 28 260081 1096 46424857
Spinal decompression 20.11 10.20 13 260096 186 46425767
Aortic valve incompetence 20.07 10.20 76 260033 5894 46420059
Gouty arthritis 20.04 10.20 19 260090 488 46425465
Skin burning sensation 20.03 10.20 18 260091 10674 46415279
Bradyphrenia 20.02 10.20 5 260104 6225 46419728
Labile hypertension 20.01 10.20 19 260090 489 46425464
Incorrect route of product administration 19.98 10.20 38 260071 16345 46409608
Parathyroid tumour benign 19.91 10.20 21 260088 615 46425338
Spondylitis 19.83 10.20 38 260071 1957 46423996
Creatinine renal clearance decreased 19.61 10.20 7 260102 6913 46419040
Infusion site erythema 19.59 10.20 9 260100 7633 46418320
Supraventricular extrasystoles 19.58 10.20 59 260050 4070 46421883
Maternal exposure during pregnancy 19.55 10.20 727 259382 101822 46324131
Mastectomy 19.46 10.20 32 260077 1459 46424494
Throat tightness 19.43 10.20 55 260054 20584 46405369
Muscle spasticity 19.43 10.20 21 260088 11419 46414534
Hypergammaglobulinaemia benign monoclonal 19.37 10.20 21 260088 635 46425318
Gingival ulceration 19.36 10.20 25 260084 913 46425040
Ureterolithiasis 19.31 10.20 35 260074 1727 46424226
Blepharitis 19.31 10.20 40 260069 2181 46423772
Breath odour 19.31 10.20 32 260077 1469 46424484
Laboratory test abnormal 19.29 10.20 64 260045 22783 46403170
Uterine polyp 19.24 10.20 35 260074 1732 46424221
Pathogen resistance 19.22 10.20 5 260104 6055 46419898
Coma 19.21 10.20 220 259889 58129 46367824
Haemodialysis 19.16 10.20 14 260095 9203 46416750
Major depression 19.15 10.20 81 260028 6609 46419344
Dental discomfort 19.07 10.20 15 260094 297 46425656
Blood pressure fluctuation 18.99 10.20 96 260013 30352 46395601
Urinary retention postoperative 18.99 10.20 6 260103 11 46425942
Uterovaginal prolapse 18.93 10.20 9 260100 67 46425886
Tooth discolouration 18.93 10.20 23 260086 789 46425164
Hypoxia 18.85 10.20 191 259918 51647 46374306
Artificial crown procedure 18.83 10.20 14 260095 254 46425699
Productive cough 18.80 10.20 186 259923 50529 46375424
Blood calcium increased 18.80 10.20 88 260021 7499 46418454
Spinal deformity 18.76 10.20 25 260084 942 46425011
Large intestine benign neoplasm 18.71 10.20 10 260099 98 46425855
Blood creatine phosphokinase increased 18.70 10.20 85 260024 27639 46398314
Device occlusion 18.67 10.20 5 260104 5940 46420013
Pneumonitis 18.66 10.20 88 260021 28332 46397621
Tachypnoea 18.66 10.20 32 260077 14319 46411634
Benign gastric neoplasm 18.65 10.20 5 260104 3 46425950
Hallucination 18.60 10.20 183 259926 49768 46376185
Metastases to liver 18.58 10.20 52 260057 19533 46406420
Duodenitis 18.57 10.20 50 260059 3233 46422720
Labelled drug-drug interaction medication error 18.53 10.20 14 260095 9047 46416906
Cardiac failure acute 18.51 10.20 11 260098 8067 46417886
Myocarditis 18.51 10.20 10 260099 7729 46418224
Chondrocalcinosis pyrophosphate 18.48 10.20 25 260084 956 46424997
Dystrophic calcification 18.45 10.20 10 260099 101 46425852
Glycosylated haemoglobin increased 18.43 10.20 20 260089 10856 46415097
End stage renal disease 18.39 10.20 5 260104 5881 46420072
Mammoplasty 18.37 10.20 17 260092 423 46425530
Affect lability 18.27 10.20 11 260098 8009 46417944
Haemophagocytic lymphohistiocytosis 18.23 10.20 12 260097 8330 46417623
White blood cell count increased 18.19 10.20 158 259951 44061 46381892
Pharyngeal oedema 18.15 10.20 33 260076 14438 46411515
Device malfunction 18.15 10.20 29 260080 13345 46412608
Vaginal prolapse 18.11 10.20 17 260092 431 46425522
Pelvic floor muscle weakness 18.07 10.20 7 260102 29 46425924
Progressive multifocal leukoencephalopathy 18.00 10.20 22 260087 11324 46414629
Carotid endarterectomy 17.99 10.20 11 260098 142 46425811
Tongue geographic 17.98 10.20 9 260100 76 46425877
Muscle twitching 17.92 10.20 34 260075 14638 46411315
Generalised oedema 17.91 10.20 33 260076 14366 46411587
Red blood cell sedimentation rate 17.90 10.20 34 260075 1739 46424214
Lip and/or oral cavity cancer 17.89 10.20 14 260095 275 46425678
Allergy to arthropod sting 17.88 10.20 9 260100 77 46425876
Haemoptysis 17.84 10.20 80 260029 26109 46399844
Salivary gland mass 17.78 10.20 9 260100 78 46425875
Metastases to lung 17.76 10.20 20 260089 10676 46415277
Menopausal symptoms 17.71 10.20 35 260074 1844 46424109
Urinary tract disorder 17.68 10.20 39 260070 2221 46423732
Petechiae 17.65 10.20 27 260082 12643 46413310
Mouth cyst 17.64 10.20 10 260099 111 46425842
Delirium 17.64 10.20 128 259981 37100 46388853
Bone operation 17.62 10.20 13 260096 233 46425720
Oesophageal haemorrhage 17.60 10.20 18 260091 508 46425445
Blood lactate dehydrogenase increased 17.60 10.20 57 260052 20443 46405510
Ecchymosis 17.60 10.20 110 259999 10466 46415487
Tendon sheath incision 17.58 10.20 9 260100 80 46425873
Head discomfort 17.58 10.20 19 260090 10332 46415621
Hormone replacement therapy 17.54 10.20 5 260104 5 46425948
Cubital tunnel syndrome 17.53 10.20 12 260097 190 46425763
Device breakage 17.52 10.20 103 260006 9589 46416364
Oesophageal spasm 17.50 10.20 36 260073 1953 46424000
Mastoid disorder 17.47 10.20 6 260103 16 46425937
Anticoagulant therapy 17.47 10.20 6 260103 16 46425937
Device extrusion 17.35 10.20 7 260102 33 46425920
Procedural hypotension 17.34 10.20 27 260082 1175 46424778
Denture wearer 17.11 10.20 13 260096 244 46425709
Intestinal polyp 17.11 10.20 25 260084 1028 46424925
Underdose 17.06 10.20 54 260055 19504 46406449
Blood pressure abnormal 17.05 10.20 26 260083 12191 46413762
Breast fibrosis 16.96 10.20 6 260103 18 46425935
Deafness 16.95 10.20 150 259959 15918 46410035
Catheter site infection 16.95 10.20 3 260106 4750 46421203
Myelosuppression 16.94 10.20 11 260098 7692 46418261
Peritonitis 16.83 10.20 59 260050 20655 46405298
Injection site haemorrhage 16.82 10.20 59 260050 20650 46405303
Eosinophilia 16.81 10.20 53 260056 19164 46406789
Lipoma of breast 16.78 10.20 4 260105 0 46425953
Metatarsus primus varus 16.78 10.20 4 260105 0 46425953
Thrombosis prophylaxis 16.78 10.20 4 260105 0 46425953
Arthrotomy 16.78 10.20 4 260105 0 46425953
Uterine cervix atrophy 16.78 10.20 4 260105 0 46425953
Loss of anatomical alignment after fracture reduction 16.78 10.20 4 260105 0 46425953
Insulin-requiring type 2 diabetes mellitus 16.78 10.20 8 260101 60 46425893
Vertebrobasilar insufficiency 16.77 10.20 9 260100 89 46425864
Vitreous degeneration 16.72 10.20 6 260103 19 46425934
Oesophageal cancer metastatic 16.70 10.20 10 260099 124 46425829
Breast operation 16.69 10.20 15 260094 359 46425594
Tongue disorder 16.69 10.20 82 260027 7128 46418825
Joint contracture 16.67 10.20 30 260079 1472 46424481
Hereditary angioedema 16.65 10.20 5 260104 5511 46420442
Treatment failure 16.65 10.20 393 259716 92694 46333259
Thalassaemia beta 16.64 10.20 5 260104 7 46425946
Numb chin syndrome 16.64 10.20 5 260104 7 46425946
Pre-existing condition improved 16.62 10.20 8 260101 6604 46419349
Chondropathy 16.57 10.20 35 260074 1935 46424018
Fallopian tube disorder 16.56 10.20 14 260095 308 46425645
Eustachian tube disorder 16.56 10.20 8 260101 62 46425891
Labyrinthitis 16.53 10.20 36 260073 2033 46423920
Graft versus host disease 16.52 10.20 8 260101 6580 46419373
Neurogenic bowel 16.51 10.20 9 260100 92 46425861
Joint noise 16.51 10.20 47 260062 3140 46422813
Respiratory disorder 16.51 10.20 87 260022 27213 46398740
Eye swelling 16.51 10.20 57 260052 20046 46405907
Breast hyperplasia 16.41 10.20 13 260096 260 46425693
Delusion 16.41 10.20 23 260086 11165 46414788
Muscle injury 16.40 10.20 62 260047 4804 46421149
Pancreatitis acute 16.34 10.20 77 260032 24795 46401158
Abscess neck 16.27 10.20 18 260091 557 46425396
Photosensitivity reaction 16.20 10.20 29 260080 12763 46413190
Coma scale abnormal 16.12 10.20 4 260105 5002 46420951
Device intolerance 16.12 10.20 7 260102 41 46425912
Electrocardiogram ST-T change 16.07 10.20 25 260084 1087 46424866
Medical device pain 16.05 10.20 30 260079 1516 46424437
Ovarian cystectomy 15.97 10.20 10 260099 135 46425818
Swelling face 15.96 10.20 204 259905 52855 46373098
Psychomotor hyperactivity 15.93 10.20 18 260091 9595 46416358
Repetitive strain injury 15.92 10.20 11 260098 177 46425776
Poor personal hygiene 15.90 10.20 14 260095 326 46425627
Hallucination, auditory 15.88 10.20 22 260087 10734 46415219
Immune reconstitution inflammatory syndrome 15.87 10.20 6 260103 5719 46420234
Injection site induration 15.87 10.20 13 260096 8066 46417887
Dacryostenosis acquired 15.87 10.20 16 260093 444 46425509
Post-traumatic neck syndrome 15.86 10.20 28 260081 1353 46424600
Vascular insufficiency 15.85 10.20 12 260097 224 46425729
Complication of device insertion 15.83 10.20 4 260105 4940 46421013
Anger 15.80 10.20 26 260083 11826 46414127
Hemiparesis 15.75 10.20 58 260051 20011 46405942
Generalised anxiety disorder 15.74 10.20 31 260078 1629 46424324
International normalised ratio increased 15.73 10.20 176 259933 46707 46379246
Osteochondrosis 15.72 10.20 23 260086 947 46425006
Laryngeal neoplasm 15.65 10.20 6 260103 24 46425929
Tooth dislocation 15.65 10.20 6 260103 24 46425929
Hospice care 15.63 10.20 5 260104 5290 46420663
Hyperthermia 15.61 10.20 13 260096 8001 46417952
Poliomyelitis 15.58 10.20 7 260102 45 46425908
Feeling cold 15.56 10.20 53 260056 18718 46407235
Surgery 15.56 10.20 236 259873 28549 46397404
Calcinosis 15.54 10.20 32 260077 1737 46424216
Skin fissures 15.53 10.20 12 260097 7668 46418285
Ventricular fibrillation 15.53 10.20 25 260084 11471 46414482
Intervertebral disc displacement 15.47 10.20 16 260093 458 46425495
Pseudarthrosis 15.39 10.20 15 260094 399 46425554
Wound dehiscence 15.33 10.20 58 260051 4496 46421457
Drug dependence 15.30 10.20 58 260051 19843 46406110
Hypereosinophilic syndrome 15.28 10.20 12 260097 237 46425716
Parathyroid gland operation 15.28 10.20 6 260103 26 46425927
Vitreous detachment 15.27 10.20 32 260077 1759 46424194
Pyogenic granuloma 15.26 10.20 13 260096 289 46425664
Jaundice 15.25 10.20 96 260013 28749 46397204
Hypotonia 15.24 10.20 14 260095 8215 46417738
Symphysiolysis 15.22 10.20 5 260104 11 46425942
Increased appetite 15.22 10.20 15 260094 8512 46417441
Mania 15.21 10.20 23 260086 10823 46415130
Large intestinal polypectomy 15.15 10.20 11 260098 192 46425761
Pollakiuria 15.14 10.20 204 259905 24057 46401896
Diabetic neuropathy 15.10 10.20 51 260058 3738 46422215
Lipohypertrophy 15.04 10.20 20 260089 752 46425201
Cushingoid 15.03 10.20 72 260037 6194 46419759
Thyroid disorder 15.02 10.20 117 259992 11959 46413994
Neurosensory hypoacusis 15.00 10.20 13 260096 296 46425657
Speech disorder 14.98 10.20 129 259980 36038 46389915
Neutrophil count increased 14.93 10.20 36 260073 14217 46411736
Gastrointestinal toxicity 14.88 10.20 3 260106 4328 46421625
Ill-defined disorder 14.86 10.20 88 260021 26739 46399214
Vascular headache 14.85 10.20 7 260102 51 46425902
Gallbladder disorder 14.83 10.20 156 259953 17342 46408611
Urinary bladder polyp 14.74 10.20 8 260101 81 46425872
Bacteraemia 14.71 10.20 36 260073 14143 46411810
Therapy change 14.68 10.20 5 260104 5085 46420868
Hepatic cyst 14.66 10.20 59 260050 4707 46421246
Pharyngo-oesophageal diverticulum 14.65 10.20 5 260104 13 46425940
Electrocardiogram QRS complex prolonged 14.63 10.20 6 260103 5443 46420510
Osteodystrophy 14.56 10.20 4 260105 3 46425950
Joint irrigation 14.56 10.20 4 260105 3 46425950
Intestinal adhesion lysis 14.56 10.20 4 260105 3 46425950
Spider vein 14.54 10.20 12 260097 255 46425698
Tympanic membrane perforation 14.52 10.20 28 260081 1449 46424504
Suspected suicide 14.49 10.20 4 260105 4657 46421296
Haemodynamic instability 14.48 10.20 13 260096 7712 46418241
Retching 14.47 10.20 32 260077 13025 46412928
Weight bearing difficulty 14.46 10.20 36 260073 2219 46423734
Breast cancer in situ 14.45 10.20 28 260081 1454 46424499
Retinal operation 14.43 10.20 6 260103 31 46425922
Ludwig angina 14.43 10.20 6 260103 31 46425922
Red cell distribution width increased 14.40 10.20 13 260096 7691 46418262
Family stress 14.39 10.20 17 260092 566 46425387
Glomerular filtration rate decreased 14.37 10.20 27 260082 11667 46414286
Allergy to vaccine 14.36 10.20 10 260099 163 46425790
Elbow operation 14.31 10.20 12 260097 261 46425692
Medication error 14.30 10.20 107 260002 30804 46395149
Musculoskeletal chest pain 14.23 10.20 159 259950 17947 46408006
Anaemia vitamin B12 deficiency 14.20 10.20 14 260095 378 46425575
Vascular operation 14.18 10.20 8 260101 88 46425865
Infusion site swelling 14.17 10.20 7 260102 5692 46420261
Polyarthritis 14.15 10.20 73 260036 6469 46419484
Vulva cyst 14.13 10.20 5 260104 15 46425938
Rectocele repair 14.13 10.20 5 260104 15 46425938
Back injury 14.13 10.20 76 260033 6845 46419108
Colitis ulcerative 14.08 10.20 51 260058 17681 46408272
Osteochondroma 14.03 10.20 4 260105 4 46425949
Cholecystitis chronic 14.03 10.20 23 260086 10476 46415477
Hypoaesthesia 14 10.20 531 259578 118338 46307615
Breast cancer metastatic 13.98 10.20 35 260074 13643 46412310
Papilloma 13.97 10.20 11 260098 218 46425735
Oesophageal adenocarcinoma 13.95 10.20 10 260099 171 46425782
Gastrointestinal tract adenoma 13.93 10.20 13 260096 327 46425626
Hypersomnia 13.91 10.20 42 260067 15397 46410556
Sebaceous hyperplasia 13.89 10.20 5 260104 16 46425937
Callus formation delayed 13.89 10.20 5 260104 16 46425937
Wrong product administered 13.87 10.20 7 260102 5623 46420330
Extrapyramidal disorder 13.86 10.20 26 260083 11242 46414711
Post procedural hypothyroidism 13.85 10.20 9 260100 130 46425823
Expired product administered 13.84 10.20 7 260102 5615 46420338
Animal bite 13.83 10.20 36 260073 2281 46423672
Hyperaesthesia 13.81 10.20 14 260095 7842 46418111
Soft tissue inflammation 13.81 10.20 11 260098 222 46425731
Ligament rupture 13.80 10.20 39 260070 2594 46423359
Haemangioma of liver 13.75 10.20 23 260086 1064 46424889
Night sweats 13.74 10.20 92 260017 27158 46398795
Hepatic necrosis 13.74 10.20 7 260102 5594 46420359
Mouth ulceration 13.74 10.20 218 259891 26614 46399339
Hypocalcaemia 13.73 10.20 90 260019 26695 46399258
Cold sweat 13.69 10.20 25 260084 10920 46415033
Clonus 13.66 10.20 3 260106 4077 46421876
Drug level decreased 13.62 10.20 8 260101 5904 46420049
Dermatitis acneiform 13.61 10.20 3 260106 4067 46421886
Mental status changes 13.58 10.20 141 259968 37947 46388006
Menopause 13.56 10.20 34 260075 2105 46423848
Dementia 13.56 10.20 135 259974 14795 46411158
Tongue ulceration 13.55 10.20 43 260066 3050 46422903
Giant cell arteritis 13.55 10.20 31 260078 1810 46424143
Stomatitis necrotising 13.51 10.20 8 260101 97 46425856
Menstruation irregular 13.51 10.20 10 260099 6529 46419424
Inappropriate schedule of product administration 13.50 10.20 268 259841 64745 46361208
Aplastic anaemia 13.45 10.20 12 260097 7141 46418812
Leriche syndrome 13.45 10.20 5 260104 18 46425935
Oesophagitis chemical 13.45 10.20 5 260104 18 46425935
Cystocele repair 13.45 10.20 5 260104 18 46425935
Hypertrophy 13.44 10.20 14 260095 404 46425549
Paranoia 13.44 10.20 24 260085 10573 46415380
Femoral hernia 13.43 10.20 6 260103 38 46425915
Shoulder arthroplasty 13.43 10.20 43 260066 3065 46422888
Emotional distress 13.41 10.20 108 260001 30599 46395354
Electrolyte imbalance 13.38 10.20 50 260059 17176 46408777
Hepatosplenic T-cell lymphoma 13.37 10.20 17 260092 611 46425342
Deafness neurosensory 13.32 10.20 55 260054 4439 46421514
Eye pruritus 13.32 10.20 29 260080 11869 46414084
Cyanosis 13.31 10.20 45 260064 15926 46410027
Sickle cell anaemia with crisis 13.23 10.20 3 260106 3989 46421964
Ganglioneuroma 13.23 10.20 9 260100 141 46425812
Respiratory acidosis 13.23 10.20 9 260100 6139 46419814
Bone density increased 13.18 10.20 13 260096 351 46425602
Blood count abnormal 13.17 10.20 53 260056 17825 46408128
Dysplastic naevus syndrome 13.15 10.20 4 260105 6 46425947
Peroneal nerve palsy 13.14 10.20 52 260057 4116 46421837
Nodal osteoarthritis 13.12 10.20 19 260090 775 46425178
Sinusitis 13.09 10.20 590 259519 129178 46296775
Astigmatism 13.06 10.20 20 260089 858 46425095
Vaginal dysplasia 13.05 10.20 6 260103 41 46425912
Presbyoesophagus 13.04 10.20 5 260104 20 46425933
Osteolysis 13.03 10.20 38 260071 2574 46423379
Dermatitis bullous 13.01 10.20 14 260095 7629 46418324
Pain 13 10.20 2923 257186 474025 45951928
Electrocardiogram abnormal 12.99 10.20 75 260034 6937 46419016
Hyperammonaemia 12.98 10.20 5 260104 4711 46421242
Central nervous system lesion 12.91 10.20 21 260088 9594 46416359
Lentigo 12.90 10.20 11 260098 245 46425708
Incisional hernia 12.87 10.20 26 260083 1392 46424561
Lipoma excision 12.85 10.20 5 260104 21 46425932
Oesophagitis haemorrhagic 12.85 10.20 14 260095 426 46425527
Bladder operation 12.84 10.20 19 260090 790 46425163
Diastolic dysfunction 12.83 10.20 61 260048 5231 46420722
Pharyngitis streptococcal 12.83 10.20 17 260092 8451 46417502
Transplant dysfunction 12.83 10.20 5 260104 4677 46421276
Gastrointestinal tract mucosal pigmentation 12.83 10.20 16 260093 564 46425389
Breast disorder female 12.81 10.20 7 260102 72 46425881
Lymphopenia 12.80 10.20 43 260066 15250 46410703
Modified radical mastectomy 12.78 10.20 4 260105 7 46425946
Vascular skin disorder 12.78 10.20 4 260105 7 46425946
Bronchial hyperreactivity 12.77 10.20 26 260083 1400 46424553
Metastases to bone 12.75 10.20 52 260057 17424 46408529
Atrial septal defect 12.67 10.20 10 260099 6322 46419631
Breast necrosis 12.65 10.20 9 260100 152 46425801
Anaemia 12.64 10.20 1240 258869 254539 46171414
Tonsil cancer 12.63 10.20 10 260099 200 46425753
Bundle branch block bilateral 12.59 10.20 3 260106 0 46425953
Vaginal stricture 12.59 10.20 3 260106 0 46425953
Arterial bruit 12.59 10.20 3 260106 0 46425953
Diverticulitis oesophageal 12.59 10.20 3 260106 0 46425953
Fracture debridement 12.59 10.20 3 260106 0 46425953
Prolapse repair 12.59 10.20 3 260106 0 46425953
Benign neoplasm of spinal cord 12.59 10.20 3 260106 0 46425953
Mastoid abscess 12.59 10.20 3 260106 0 46425953
Epidural fibrosis 12.59 10.20 3 260106 0 46425953
Reaction to food additive 12.59 10.20 3 260106 0 46425953
Traumatic arthropathy 12.59 10.20 3 260106 0 46425953
Deafness traumatic 12.59 10.20 3 260106 0 46425953
Articular disc disorder 12.59 10.20 3 260106 0 46425953
Erythroplasia 12.59 10.20 3 260106 0 46425953
Anhedonia 12.58 10.20 24 260085 10311 46415642
Hypoacusis 12.55 10.20 175 259934 20794 46405159
Soft tissue injury 12.54 10.20 20 260089 889 46425064
Inguinal hernia 12.51 10.20 25 260084 1328 46424625
Lip neoplasm malignant stage unspecified 12.49 10.20 5 260104 23 46425930
Hysterosalpingo-oophorectomy 12.47 10.20 6 260103 46 46425907
Dyspepsia 12.47 10.20 483 259626 67989 46357964
Polypectomy 12.44 10.20 16 260093 582 46425371
Aspergillus infection 12.44 10.20 12 260097 6878 46419075
Dyspnoea exertional 12.44 10.20 201 259908 50088 46375865
Intervertebral disc annular tear 12.43 10.20 4 260105 8 46425945
Rash papular 12.42 10.20 34 260075 12864 46413089
Breast reconstruction 12.42 10.20 10 260099 205 46425748
Disseminated intravascular coagulation 12.39 10.20 59 260050 18946 46407007
Cutis laxa 12.36 10.20 9 260100 158 46425795
Seasonal allergy 12.32 10.20 121 259988 13213 46412740
Cyst removal 12.32 10.20 13 260096 381 46425572
Glossitis 12.31 10.20 39 260070 2764 46423189
Polyp 12.27 10.20 59 260050 5084 46420869
Mental disorder 12.19 10.20 74 260035 22351 46403602
Head injury 12.18 10.20 199 259910 24437 46401516
Antinuclear antibody positive 12.18 10.20 68 260041 6212 46419741
Arthrofibrosis 12.16 10.20 5 260104 25 46425928
Hepatomegaly 12.13 10.20 28 260081 11225 46414728
Taste disorder 12.13 10.20 9 260100 5869 46420084
Osteoma cutis 12.12 10.20 4 260105 9 46425944
Hypophosphatasia 12.12 10.20 4 260105 9 46425944
Haematochezia 12.09 10.20 142 259967 37351 46388602
Eye laser surgery 12.05 10.20 6 260103 50 46425903
Fibromyalgia 12.05 10.20 277 259832 36186 46389767
Acute respiratory failure 12.04 10.20 104 260005 29034 46396919
Psoriatic arthropathy 12.03 10.20 137 259972 36242 46389711
Injection site extravasation 12.03 10.20 12 260097 6773 46419180
Abdominal hernia repair 12.03 10.20 7 260102 82 46425871
Bundle branch block right 12.02 10.20 56 260053 4763 46421190
Joint stiffness 11.99 10.20 95 260014 27013 46398940
Gastric perforation 11.97 10.20 24 260085 1278 46424675
Kidney transplant rejection 11.96 10.20 4 260105 4114 46421839
Thyroidectomy 11.90 10.20 20 260089 929 46425024
Piriformis syndrome 11.89 10.20 9 260100 168 46425785
Umbilical hernia repair 11.89 10.20 8 260101 123 46425830
Metaplasia 11.85 10.20 14 260095 466 46425487
Jaw clicking 11.85 10.20 5 260104 27 46425926
Neoplasm skin 11.83 10.20 20 260089 933 46425020
Lithotripsy 11.83 10.20 4 260105 10 46425943
Neck injury 11.82 10.20 28 260081 1672 46424281
Aortic disorder 11.82 10.20 17 260092 689 46425264
Open angle glaucoma 11.81 10.20 11 260098 276 46425677
Iodine allergy 11.76 10.20 15 260094 541 46425412
Reversible airways obstruction 11.76 10.20 15 260094 541 46425412
White blood cell count abnormal 11.74 10.20 7 260102 5125 46420828
Hernia repair 11.71 10.20 22 260087 1116 46424837
Pedal pulse decreased 11.70 10.20 5 260104 28 46425925
Chondrosarcoma 11.67 10.20 8 260101 127 46425826
Middle insomnia 11.67 10.20 22 260087 9493 46416460
Foreign body aspiration 11.66 10.20 9 260100 173 46425780
Synovectomy 11.66 10.20 9 260100 173 46425780
Focal segmental glomerulosclerosis 11.66 10.20 25 260084 1396 46424557
Occult blood positive 11.63 10.20 45 260064 3525 46422428
Forced expiratory volume decreased 11.63 10.20 7 260102 5097 46420856
Hypertensive crisis 11.59 10.20 38 260071 13577 46412376
Klebsiella infection 11.57 10.20 12 260097 6650 46419303
Myofascitis 11.56 10.20 4 260105 11 46425942
Borderline glaucoma 11.56 10.20 4 260105 11 46425942
Ear pain 11.51 10.20 180 259929 21912 46404041
Hemiplegia 11.49 10.20 13 260096 6925 46419028
Dermatitis exfoliative 11.47 10.20 9 260100 5707 46420246
Pulmonary congestion 11.46 10.20 43 260066 14756 46411197
Oesophageal irritation 11.46 10.20 8 260101 131 46425822
Shock haemorrhagic 11.42 10.20 19 260090 8605 46417348
Hypervitaminosis 11.42 10.20 5 260104 30 46425923
Gingival atrophy 11.42 10.20 5 260104 30 46425923
Tooth injury 11.41 10.20 20 260089 961 46424992
Gingival operation 11.40 10.20 8 260101 132 46425821
Injection site discolouration 11.39 10.20 13 260096 6897 46419056
Urine calcium decreased 11.30 10.20 4 260105 12 46425941
Dysphagia 11.30 10.20 533 259576 76779 46349174
Pericoronitis 11.28 10.20 5 260104 31 46425922
Gingival injury 11.28 10.20 5 260104 31 46425922
Mandibular mass 11.28 10.20 9 260100 182 46425771
Ligament disorder 11.26 10.20 13 260096 422 46425531
Aplasia 11.24 10.20 3 260106 3573 46422380
Complex regional pain syndrome 11.22 10.20 31 260078 2035 46423918
Ketoacidosis 11.21 10.20 4 260105 3951 46422002
Osteonecrosis of external auditory canal 11.21 10.20 7 260102 94 46425859
Blood potassium decreased 11.20 10.20 147 259962 37916 46388037
Myocardial infarction 11.19 10.20 437 259672 97091 46328862
Peri-implantitis 11.15 10.20 5 260104 32 46425921
Laparoscopy 11.15 10.20 5 260104 32 46425921
Nervous system disorder 11.15 10.20 49 260060 16080 46409873
IVth nerve paralysis 11.15 10.20 5 260104 32 46425921
High turnover osteopathy 11.15 10.20 5 260104 32 46425921
Leiomyoma 11.15 10.20 12 260097 360 46425593
Acidosis 11.10 10.20 29 260080 11145 46414808
Wheezing 11.10 10.20 220 259889 53166 46372787
Conjunctivitis 11.03 10.20 133 259976 15291 46410662
Cholelithiasis obstructive 11.02 10.20 5 260104 33 46425920
Nasal septal operation 11.02 10.20 7 260102 97 46425856
Haemolytic anaemia 11.01 10.20 24 260085 9818 46416135
Macrocytosis 11.01 10.20 33 260076 2270 46423683
Polycythaemia vera 11.00 10.20 8 260101 140 46425813
Cervical dysplasia 10.99 10.20 39 260070 2930 46423023
Bone abscess 10.97 10.20 10 260099 244 46425709
Frequent bowel movements 10.93 10.20 35 260074 12597 46413356
Swollen tongue 10.92 10.20 107 260002 29125 46396828
Collagen disorder 10.92 10.20 9 260100 191 46425762
Fibroma 10.88 10.20 19 260090 910 46425043
Breast neoplasm 10.88 10.20 23 260086 1272 46424681
Upper-airway cough syndrome 10.88 10.20 78 260031 7769 46418184
Transient ischaemic attack 10.88 10.20 263 259846 34640 46391313
Sinus polyp 10.86 10.20 11 260098 307 46425646
Aortic bruit 10.84 10.20 4 260105 14 46425939
Spinal rod insertion 10.84 10.20 4 260105 14 46425939
Dermatitis contact 10.83 10.20 80 260029 8043 46417910
Macular hole 10.83 10.20 17 260092 745 46425208
Adhesion 10.82 10.20 23 260086 1277 46424676
Staphylococcal bacteraemia 10.79 10.20 7 260102 4897 46421056
Pelvic mass 10.74 10.20 21 260088 1098 46424855
Pneumonia aspiration 10.73 10.20 241 259868 31364 46394589
Bone trimming 10.71 10.20 6 260103 65 46425888
Complications of bone marrow transplant 10.70 10.20 13 260096 446 46425507
Gastrointestinal infection 10.69 10.20 14 260095 6996 46418957
Stomatitis 10.69 10.20 294 259815 68003 46357950
Therapeutic response shortened 10.67 10.20 8 260101 5191 46420762
Alanine aminotransferase increased 10.66 10.20 394 259715 88057 46337896
Sigmoidectomy 10.63 10.20 4 260105 15 46425938
Salivary gland adenoma 10.63 10.20 4 260105 15 46425938
Hernia obstructive 10.63 10.20 6 260103 66 46425887
Renal tubular necrosis 10.63 10.20 28 260081 10731 46415222
Amaurosis 10.62 10.20 14 260095 522 46425431
Gastric polyps 10.61 10.20 32 260077 2208 46423745
Needle issue 10.60 10.20 10 260099 5794 46420159
Respiration abnormal 10.58 10.20 6 260103 4515 46421438
Oesophagitis ulcerative 10.58 10.20 14 260095 524 46425429
Restrictive pulmonary disease 10.56 10.20 22 260087 1204 46424749
Electrocardiogram Q wave abnormal 10.56 10.20 6 260103 67 46425886
Aortic valve sclerosis 10.55 10.20 20 260089 1022 46424931
Menstrual disorder 10.54 10.20 5 260104 4163 46421790
Arthroscopic surgery 10.54 10.20 5 260104 37 46425916
Post polio syndrome 10.52 10.20 3 260106 3 46425950
Hypoaesthesia teeth 10.52 10.20 3 260106 3 46425950
Plica syndrome 10.52 10.20 3 260106 3 46425950
Asbestosis 10.52 10.20 3 260106 3 46425950
Keratomileusis 10.52 10.20 3 260106 3 46425950
Femoral hernia repair 10.52 10.20 3 260106 3 46425950
Foraminotomy 10.52 10.20 3 260106 3 46425950
Lactobacillus infection 10.52 10.20 3 260106 3 46425950
Biopsy thyroid gland 10.52 10.20 3 260106 3 46425950
Procedural nausea 10.52 10.20 16 260093 682 46425271
Ventricular arrhythmia 10.51 10.20 3 260106 3418 46422535
Respiratory syncytial virus infection 10.51 10.20 7 260102 4828 46421125
Galactorrhoea 10.49 10.20 4 260105 3793 46422160
Chorioretinitis 10.49 10.20 11 260098 320 46425633
Feeding disorder 10.48 10.20 26 260083 10168 46415785
Grip strength decreased 10.46 10.20 20 260089 8586 46417367
Lipase increased 10.45 10.20 20 260089 8583 46417370
Abscess soft tissue 10.43 10.20 7 260102 107 46425846
Femoroacetabular impingement 10.43 10.20 4 260105 16 46425937
Colon cancer stage II 10.43 10.20 5 260104 38 46425915
Haemolysis 10.42 10.20 11 260098 6048 46419905
Pneumonia viral 10.34 10.20 13 260096 6611 46419342
Catatonia 10.34 10.20 4 260105 3758 46422195
Dysstasia 10.30 10.20 57 260052 17611 46408342
Injection site nodule 10.28 10.20 3 260106 3368 46422585
Implant site reaction 10.27 10.20 8 260101 156 46425797
Dental care 10.26 10.20 20 260089 1043 46424910
Breast cyst excision 10.26 10.20 6 260103 71 46425882
Pharyngeal cyst 10.25 10.20 4 260105 17 46425936
Temperature regulation disorder 10.23 10.20 3 260106 3357 46422596
Nystagmus 10.20 10.20 10 260099 5689 46420264

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis 352.47 10.39 224 34331 15911 29902012
Osteonecrosis of jaw 302.29 10.39 215 34340 18403 29899520
Femur fracture 270.50 10.39 143 34412 7166 29910757
Low turnover osteopathy 164.13 10.39 35 34520 68 29917855
Atypical femur fracture 155.82 10.39 42 34513 289 29917634
Osteoporosis 150.05 10.39 113 34442 10550 29907373
Impaired healing 128.56 10.39 117 34438 14223 29903700
Osteomyelitis 122.35 10.39 115 34440 14566 29903357
Dental caries 108.00 10.39 66 34489 4365 29913558
Intramedullary rod insertion 105.33 10.39 20 34535 13 29917910
Bone density decreased 99.15 10.39 46 34509 1732 29916191
Toxicity to various agents 97.93 10.39 41 34514 177142 29740781
Completed suicide 97.53 10.39 4 34551 99488 29818435
Atypical fracture 96.19 10.39 22 34533 67 29917856
Open reduction of fracture 83.94 10.39 17 34538 22 29917901
Stress fracture 80.27 10.39 32 34523 825 29917098
Death 71.17 10.39 196 34359 357087 29560836
Osteoarthritis 70.39 10.39 96 34459 18253 29899670
Drug abuse 69.56 10.39 7 34548 82065 29835858
Tibia fracture 65.08 10.39 32 34523 1373 29916550
Tooth disorder 63.68 10.39 65 34490 9096 29908827
Periodontal disease 62.08 10.39 26 34529 763 29917160
Hypophosphataemic osteomalacia 60.68 10.39 16 34539 100 29917823
Tooth loss 60.16 10.39 44 34511 3925 29913998
Osteopenia 58.25 10.39 46 34509 4602 29913321
Tooth fracture 55.97 10.39 39 34516 3223 29914700
Febrile neutropenia 55.26 10.39 27 34528 106666 29811257
Exostosis of jaw 53.30 10.39 14 34541 86 29917837
Hypercalciuria 50.99 10.39 16 34539 198 29917725
Jaw disorder 50.77 10.39 32 34523 2235 29915688
Internal fixation of fracture 49.94 10.39 12 34543 48 29917875
Drug ineffective 48.64 10.39 215 34340 340172 29577751
Fracture nonunion 48.53 10.39 15 34540 176 29917747
Spinal compression fracture 48.44 10.39 47 34508 6187 29911736
Bone fissure 46.37 10.39 10 34545 21 29917902
Temporomandibular joint syndrome 46.34 10.39 21 34534 748 29917175
Resorption bone increased 44.97 10.39 12 34543 79 29917844
Craniotabes 43.87 10.39 9 34546 13 29917910
Jaw fracture 43.77 10.39 22 34533 990 29916933
Exostosis 42.88 10.39 34 34521 3421 29914502
Fall 41.28 10.39 354 34201 181518 29736405
Exposed bone in jaw 41.27 10.39 26 34529 1814 29916109
Arthralgia 41.25 10.39 283 34272 135508 29782415
Gastrooesophageal reflux disease 41.20 10.39 105 34450 32150 29885773
Spinal fracture 40.01 10.39 44 34511 6704 29911219
Foot fracture 39.27 10.39 35 34520 4137 29913786
Anaemia postoperative 39.18 10.39 17 34538 545 29917378
Blood immunoglobulin E increased 37.69 10.39 24 34531 1706 29916217
Oral infection 37.15 10.39 24 34531 1749 29916174
Tooth abscess 36.77 10.39 37 34518 5089 29912834
Spinal osteoarthritis 36.69 10.39 41 34514 6358 29911565
Pain in jaw 35.59 10.39 56 34499 12100 29905823
Neutropenia 35.03 10.39 59 34496 128481 29789442
Oesophageal ulcer 33.88 10.39 29 34526 3248 29914675
Cataract 33.15 10.39 76 34479 21759 29896164
Periodontitis 33.07 10.39 22 34533 1685 29916238
Rib fracture 32.37 10.39 55 34500 12665 29905258
Nausea 32.08 10.39 206 34349 296751 29621172
Thrombocytopenia 32.01 10.39 69 34486 136975 29780948
Bone disorder 31.68 10.39 39 34516 6702 29911221
Laryngeal ulceration 31.56 10.39 10 34545 128 29917795
Dental fistula 31.42 10.39 10 34545 130 29917793
Scoliosis 31.30 10.39 21 34534 1631 29916292
Medical device removal 30.11 10.39 10 34545 150 29917773
Fracture delayed union 29.56 10.39 8 34547 56 29917867
Intentional overdose 29.42 10.39 6 34549 41475 29876448
Hyperlipidaemia 28.83 10.39 55 34500 13852 29904071
Fibula fracture 28.64 10.39 15 34540 736 29917187
Blood parathyroid hormone decreased 28.40 10.39 13 34542 474 29917449
Rheumatoid arthritis 28.23 10.39 108 34447 41089 29876834
Sleep apnoea syndrome 28.21 10.39 61 34494 16796 29901127
Arthropathy 28.06 10.39 69 34486 20658 29897265
Acetabulum fracture 27.91 10.39 11 34544 275 29917648
Hiatus hernia 27.04 10.39 37 34518 7053 29910870
Asthma 26.59 10.39 97 34458 36077 29881846
Thoracic vertebral fracture 26.56 10.39 18 34537 1422 29916501
Oesophageal carcinoma 26.51 10.39 25 34530 3176 29914747
Hypophosphatasia 26.06 10.39 6 34549 19 29917904
Gingival disorder 25.81 10.39 17 34538 1280 29916643
Diverticulitis 25.69 10.39 60 34495 17385 29900538
Dental necrosis 25.60 10.39 6 34549 21 29917902
Nerve degeneration 25.53 10.39 9 34546 163 29917760
Rhinitis allergic 24.73 10.39 23 34532 2871 29915052
Pathological fracture 24.63 10.39 27 34528 4099 29913824
Gastritis 23.99 10.39 64 34491 20134 29897789
Bursitis 23.95 10.39 28 34527 4558 29913365
Ankle fracture 23.74 10.39 25 34530 3626 29914297
Gingivitis 23.58 10.39 23 34532 3047 29914876
Coma 22.87 10.39 9 34546 40440 29877483
Periprosthetic fracture 22.64 10.39 8 34547 146 29917777
Benign prostatic hyperplasia 22.50 10.39 42 34513 10405 29907518
Intervertebral disc degeneration 22.48 10.39 29 34526 5222 29912701
Calcium deficiency 22.44 10.39 8 34547 150 29917773
Basal cell carcinoma 22.29 10.39 54 34501 16014 29901909
Pyrexia 22.21 10.39 225 34330 294264 29623659
Hip fracture 21.84 10.39 43 34512 11081 29906842
Corneal abrasion 21.72 10.39 9 34546 257 29917666
Bone metabolism disorder 21.65 10.39 9 34546 259 29917664
Leukopenia 21.31 10.39 20 34535 56139 29861784
Renal mass 21.28 10.39 16 34539 1488 29916435
Tooth extraction 21.27 10.39 27 34528 4784 29913139
Lumbar spinal stenosis 21.15 10.39 20 34535 2550 29915373
Suicide attempt 21.02 10.39 8 34547 36689 29881234
Extraskeletal ossification 20.81 10.39 5 34550 20 29917903
Disease progression 20.53 10.39 38 34517 79836 29838087
Rectal haemorrhage 20.27 10.39 87 34468 34852 29883071
Bone loss 20.19 10.39 11 34544 585 29917338
Hypotension 20.17 10.39 142 34413 200423 29717500
Kyphosis 19.85 10.39 13 34542 970 29916953
Pulmonary fibrosis 19.53 10.39 51 34504 15839 29902084
Rhabdomyolysis 19.40 10.39 27 34528 63553 29854370
Lactic acidosis 19.27 10.39 6 34549 31207 29886716
Intentional product misuse 19.13 10.39 8 34547 34659 29883264
Cardiac arrest 19.07 10.39 50 34505 92800 29825123
Back pain 18.84 10.39 191 34364 102405 29815518
Joint dislocation 18.79 10.39 21 34534 3257 29914666
Bone abscess 18.72 10.39 7 34548 151 29917772
Trismus 18.69 10.39 18 34537 2347 29915576
Vomiting 18.67 10.39 163 34392 219655 29698268
Pelvic cyst 18.60 10.39 5 34550 34 29917889
Bone infarction 18.60 10.39 8 34547 251 29917672
Infusion related reaction 18.39 10.39 94 34461 40470 29877453
Lumbar vertebral fracture 18.31 10.39 16 34539 1842 29916081
Oral disorder 18.28 10.39 23 34532 4039 29913884
Device breakage 18.11 10.39 15 34540 1605 29916318
Abscess jaw 18.01 10.39 11 34544 726 29917197
Myelomalacia 17.89 10.39 5 34550 40 29917883
Chronic obstructive pulmonary disease 17.62 10.39 102 34453 46024 29871899
Alveolar osteitis 17.57 10.39 5 34550 43 29917880
Oral cavity fistula 17.47 10.39 7 34548 183 29917740
Hepatocellular injury 17.42 10.39 4 34551 25467 29892456
Benign oesophageal neoplasm 17.30 10.39 3 34552 0 29917923
Steroid therapy 17.30 10.39 3 34552 0 29917923
Renal cyst 17.26 10.39 32 34523 7885 29910038
Compression fracture 16.98 10.39 19 34536 2950 29914973
Poor dental condition 16.89 10.39 7 34548 200 29917723
Limb asymmetry 16.81 10.39 5 34550 51 29917872
Diarrhoea 16.77 10.39 278 34277 333825 29584098
Arthritis 16.73 10.39 64 34491 24337 29893586
Pneumonectomy 16.64 10.39 5 34550 53 29917870
Chronic sinusitis 16.53 10.39 14 34541 1545 29916378
Liver function test abnormal 16.39 10.39 75 34480 30875 29887048
Sequestrectomy 16.06 10.39 8 34547 353 29917570
White blood cell count decreased 15.90 10.39 47 34508 83900 29834023
Acute kidney injury 15.73 10.39 222 34333 273620 29644303
Fistula discharge 15.67 10.39 8 34547 372 29917551
Enterocolitis bacterial 15.64 10.39 7 34548 242 29917681
Duodenal ulcer perforation 15.54 10.39 14 34541 1678 29916245
Epiglottis ulcer 15.44 10.39 5 34550 69 29917854
Pain 15.34 10.39 282 34273 172359 29745564
Chemical burn of respiratory tract 15.31 10.39 5 34550 71 29917852
Osteitis 14.87 10.39 13 34542 1498 29916425
Penile erythema 14.79 10.39 6 34549 162 29917761
Dermal sinus 14.76 10.39 3 34552 4 29917919
Mycobacterium chelonae infection 14.71 10.39 9 34546 596 29917327
Loose tooth 14.60 10.39 12 34543 1270 29916653
Device failure 14.49 10.39 15 34540 2133 29915790
Fatigue 14.43 10.39 272 34283 320401 29597522
Carpal tunnel syndrome 14.33 10.39 21 34534 4262 29913661
Restrictive pulmonary disease 14.18 10.39 11 34544 1072 29916851
Spinal stenosis 14.16 10.39 21 34534 4308 29913615
Pelvic fracture 14.15 10.39 15 34540 2193 29915730
Fracture 14.01 10.39 25 34530 5981 29911942
Inferior vena caval occlusion 14.00 10.39 4 34551 35 29917888
Groin pain 13.94 10.39 22 34533 4764 29913159
Oesophagitis 13.88 10.39 36 34519 11135 29906788
Micturition urgency 13.87 10.39 21 34534 4386 29913537
Renal neoplasm 13.77 10.39 11 34544 1118 29916805
JC virus CSF test positive 13.72 10.39 5 34550 100 29917823
Decreased appetite 13.69 10.39 109 34446 149801 29768122
Idiopathic pulmonary fibrosis 13.69 10.39 20 34535 4049 29913874
Osteomalacia 13.61 10.39 10 34545 898 29917025
Helicobacter test positive 13.56 10.39 8 34547 496 29917427
Cardiac failure 13.53 10.39 50 34505 83368 29834555
Body mass index increased 13.48 10.39 9 34546 693 29917230
Vertebroplasty 13.43 10.39 4 34551 41 29917882
Skin ulcer 13.39 10.39 50 34505 18799 29899124
Lung neoplasm 13.38 10.39 21 34534 4525 29913398
Herpes zoster 13.30 10.39 69 34486 29874 29888049
Cellulitis 13.28 10.39 96 34459 46688 29871235
Iron deficiency anaemia 13.24 10.39 31 34524 8993 29908930
Renal failure 13.09 10.39 91 34464 128875 29789048
Lenticular opacities 13.03 10.39 6 34549 222 29917701
Erythrasma 12.86 10.39 4 34551 48 29917875
Oral pustule 12.85 10.39 6 34549 229 29917694
Overdose 12.75 10.39 52 34503 84285 29833638
Intervertebral disc protrusion 12.69 10.39 31 34524 9240 29908683
Amino acid level increased 12.65 10.39 7 34548 384 29917539
Acute on chronic liver failure 12.57 10.39 5 34550 128 29917795
Actinic keratosis 12.54 10.39 18 34537 3585 29914338
Langerhans' cell histiocytosis 12.50 10.39 4 34551 53 29917870
Jaw cyst 12.48 10.39 3 34552 12 29917911
Peripheral sensorimotor neuropathy 12.46 10.39 11 34544 1284 29916639
Cardio-respiratory arrest 12.43 10.39 30 34525 57276 29860647
Oesophageal stenosis 12.42 10.39 12 34543 1571 29916352
Pulpitis dental 12.40 10.39 7 34548 399 29917524
Gastric ulcer 12.36 10.39 42 34513 15079 29902844
Mouth swelling 12.32 10.39 12 34543 1587 29916336
Spinal fusion surgery 12.31 10.39 9 34546 802 29917121
Oral mucosal erythema 12.24 10.39 7 34548 409 29917514
Brachycephaly 12.23 10.39 4 34551 57 29917866
Femoral neck fracture 12.21 10.39 16 34539 2926 29914997
Lower limb fracture 12.18 10.39 18 34537 3681 29914242
Foreign body 12.03 10.39 10 34545 1075 29916848
Tooth impacted 11.92 10.39 4 34551 62 29917861
Fracture displacement 11.92 10.39 4 34551 62 29917861
Foetal exposure during pregnancy 11.91 10.39 15 34540 36856 29881067
Reversible airways obstruction 11.88 10.39 6 34549 273 29917650
COVID-19 11.85 10.39 3 34552 17875 29900048
Phlebosclerosis 11.83 10.39 5 34550 150 29917773
Tooth discolouration 11.52 10.39 6 34549 291 29917632
Nasopharyngitis 11.49 10.39 111 34444 58738 29859185
Peptic ulcer 11.40 10.39 15 34540 2753 29915170
Upper gastrointestinal haemorrhage 11.38 10.39 53 34502 21975 29895948
Nasal septum deviation 11.30 10.39 9 34546 911 29917012
Retinal tear 11.20 10.39 8 34547 688 29917235
Dental plaque 11.08 10.39 3 34552 21 29917902
Hyperkalaemia 11.08 10.39 39 34516 65971 29851952
Bursa disorder 11.01 10.39 5 34550 179 29917744
Central nervous system mass 10.98 10.39 4 34551 80 29917843
Large intestine polyp 10.90 10.39 24 34531 6685 29911238
Sinus polyp 10.86 10.39 5 34550 185 29917738
Diverticulum 10.85 10.39 24 34531 6709 29911214
Abdominal rigidity 10.84 10.39 10 34545 1236 29916687
Airway remodelling 10.80 10.39 4 34551 84 29917839
Wall motion score index abnormal 10.80 10.39 4 34551 84 29917839
Abscess oral 10.78 10.39 6 34549 333 29917590
Pruritus 10.76 10.39 86 34469 118118 29799805
Tonsillar disorder 10.75 10.39 4 34551 85 29917838
Off label use 10.72 10.39 213 34342 249077 29668846
Osteoradionecrosis 10.71 10.39 4 34551 86 29917837
Small cell lung cancer 10.70 10.39 12 34543 1868 29916055
Cardiac septal defect 10.68 10.39 5 34550 192 29917731
Olfactory nerve disorder 10.63 10.39 3 34552 25 29917898
Bladder diverticulum 10.58 10.39 4 34551 89 29917834
Deafness 10.57 10.39 31 34524 10294 29907629
Epiglottitis 10.42 10.39 6 34549 355 29917568
Bronchoscopy 10.42 10.39 3 34552 27 29917896

Pharmacologic Action:

SourceCodeDescription
ATC M05BA04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates
ATC M05BB03 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB05 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB06 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
FDA CS M0006519 Diphosphonates
FDA EPC N0000175579 Bisphosphonate
CHEBI has role CHEBI:50643 ec 2.5.1.1 (dimethylallyltranstransferase) inhibitors
CHEBI has role CHEBI:50646 anti-osteoporotics
MeSH PA D050071 Bone Density Conservation Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Osteitis deformans indication 2089002 DOID:5408
Postmenopausal osteoporosis indication 102447009
Hypogonadal Osteoporosis in Males indication
Prevention of Glucocorticoid-Induced Osteoporosis indication
Glucocorticoid Induced Osteoporosis indication
Complex regional pain syndrome off-label use 128200000 DOID:3223
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Esophagitis contraindication 16761005 DOID:11963
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Ulcer of esophagus contraindication 30811009
Sarcoidosis contraindication 31541009 DOID:11335
Vitamin D deficiency contraindication 34713006
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Atrial fibrillation contraindication 49436004 DOID:0060224
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Stricture of esophagus contraindication 63305008
Hypercalcemia contraindication 66931009 DOID:12678
Fracture of femur contraindication 71620000
Duodenitis contraindication 72007001 DOID:8643
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Bed-ridden contraindication 160685001
Acute peptic ulcer contraindication 196682000
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Aseptic necrosis of bone of jaw contraindication 441809006
High Grade Dysplasia associated with Barrett's Esophagus contraindication
Esophageal Obstruction contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.27 acidic
pKa2 5.34 acidic
pKa3 6.32 acidic
pKa4 10.39 acidic
pKa5 12.82 acidic
pKa6 10.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Farnesyl pyrophosphate synthase Enzyme INHIBITOR Ki 7.35 CHEMBL CHEMBL
Protein farnesyltransferase subunit beta Enzyme IC50 7.30 WOMBAT-PK
Farnesyl pyrophosphate synthase Enzyme Ki 7.02 CHEMBL

External reference:

IDSource
2UY4M2U3RA UNII
4020932 VUID
N0000148414 NUI
D00939 KEGG_DRUG
121268-17-5 SECONDARY_CAS_RN
C0102118 UMLSCUI
CHEBI:2567 CHEBI
212 PDB_CHEM_ID
CHEMBL870 ChEMBL_ID
CHEMBL675 ChEMBL_ID
DB00630 DRUGBANK_ID
D019386 MESH_DESCRIPTOR_UI
2088 PUBCHEM_CID
6462 INN_ID
3141 IUPHAR_LIGAND_ID
203152 RXNORM
131536 MMSL
4146 MMSL
d03849 MMSL
005056 NDDF
005057 NDDF
391729003 SNOMEDCT_US
391730008 SNOMEDCT_US
421552005 SNOMEDCT_US
96290008 SNOMEDCT_US
4020932 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FOSAMAX HUMAN PRESCRIPTION DRUG LABEL 1 0006-0031 TABLET 70 mg ORAL NDA 28 sections
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0270 TABLET 70 mg ORAL NDA 27 sections
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0710 TABLET 70 mg ORAL NDA 27 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0054-0282 SOLUTION 70 mg ORAL ANDA 28 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1676 TABLET 5 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1678 TABLET 10 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1679 TABLET 35 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1680 TABLET 40 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1681 TABLET 70 mg ORAL ANDA 29 sections
Binosto HUMAN PRESCRIPTION DRUG LABEL 1 0178-0101 TABLET, EFFERVESCENT 70 mg ORAL NDA 20 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-696 TABLET 35 mg ORAL ANDA 27 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-697 TABLET 70 mg ORAL ANDA 27 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-718 TABLET 35 mg ORAL ANDA 29 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-719 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-631 TABLET 10 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-632 TABLET 35 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 16714-633 TABLET 70 mg ORAL ANDA 27 sections
Binosto HUMAN PRESCRIPTION DRUG LABEL 1 17139-400 TABLET, EFFERVESCENT 70 mg ORAL NDA 21 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-901 TABLET 35 mg ORAL ANDA 27 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-902 TABLET 70 mg ORAL ANDA 27 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-554 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-820 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-993 TABLET 35 mg ORAL ANDA 29 sections
alendronate sodium HUMAN PRESCRIPTION DRUG LABEL 1 50090-1091 TABLET 35 mg ORAL ANDA 27 sections
alendronate sodium HUMAN PRESCRIPTION DRUG LABEL 1 50090-1095 TABLET 70 mg ORAL ANDA 27 sections
Alendronate Sodium Human Prescription Drug Label 1 50090-2322 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium Human Prescription Drug Label 1 50090-2322 TABLET 70 mg ORAL ANDA 29 sections
Alendronate Sodium Human Prescription Drug Label 1 50090-3126 TABLET 70 mg ORAL ANDA 27 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 50090-3593 TABLET 35 mg ORAL ANDA 29 sections
ALENDRONULLTE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 50090-4076 TABLET 35 mg ORAL ANDA 24 sections