alendronic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium metabolism regulator, pharmaceutical aid 112 66376-36-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alendronate monosodium salt trihydrate
  • alendronate sodium trihydrate
  • alendronate sodium hydrate
  • alendronate
  • alendronic acid
  • alendronate sodium
  • aminohydroxybutane bisphosphonate
  • MK-217
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
  • Molecular weight: 249.10
  • Formula: C4H13NO7P2
  • CLOGP: -5.64
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 6
  • TPSA: 161.31
  • ALOGS: -1.17
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg O
10 mg O
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 45 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.68 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.33 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.22 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 3.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 29, 1995 FDA MERCK AND CO INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Femur fracture 18964.49 29.09 3407 10516 3332 2340830
Osteonecrosis 10889.80 29.09 2184 11739 5158 2339004
Osteoarthritis 7005.59 29.09 1508 12415 5438 2338724
Fall 6925.29 29.09 2200 11723 44899 2299263
Osteonecrosis of jaw 6329.73 29.09 1424 12499 6572 2337590
Low turnover osteopathy 6286.94 29.09 1030 12893 51 2344111
Gastrooesophageal reflux disease 4944.96 29.09 1196 12727 7899 2336263
Osteomyelitis 4441.14 29.09 928 12995 2705 2341457
Intramedullary rod insertion 4220.38 29.09 690 13233 16 2344146
Impaired healing 4072.80 29.09 928 12995 4483 2339679
Hypertension 3924.38 29.09 1265 12658 26096 2318066
Stress fracture 3792.37 29.09 688 13235 601 2343561
Tooth disorder 3600.03 29.09 799 13124 3324 2340838
Arthralgia 3568.40 29.09 1405 12518 52880 2291282
Osteoporosis 3523.92 29.09 795 13128 3619 2340543
Hyperlipidaemia 3519.00 29.09 727 13196 1947 2342215
Depression 3507.84 29.09 1171 12752 26961 2317201
Pain in extremity 3204.86 29.09 1218 12705 41322 2302840
Dental caries 3185.33 29.09 630 13293 1230 2342932
Anxiety 3023.14 29.09 1060 12863 28299 2315863
Osteopenia 2992.10 29.09 602 13321 1333 2342829
Spinal osteoarthritis 2904.49 29.09 578 13345 1179 2342983
Pain 2878.38 29.09 1253 12670 60604 2283558
Back pain 2756.52 29.09 1010 12913 30649 2313513
Bursitis 2720.32 29.09 555 13368 1353 2342809
Bone disorder 2624.21 29.09 593 13330 2699 2341463
Fracture nonunion 2513.48 29.09 426 13497 110 2344052
Foot fracture 2456.57 29.09 547 13376 2291 2341871
Vitamin D deficiency 2410.63 29.09 483 13440 1031 2343131
Arthropathy 2369.23 29.09 639 13284 6677 2337485
Intervertebral disc degeneration 2333.81 29.09 475 13448 1134 2343028
Anaemia postoperative 2144.32 29.09 367 13556 121 2344041
Atypical femur fracture 2126.57 29.09 413 13510 689 2343473
Arthritis 2090.10 29.09 620 13303 9348 2334814
Hypercholesterolaemia 2084.41 29.09 433 13490 1185 2342977
Pemphigus 2031.40 29.09 368 13555 308 2343854
Blood cholesterol increased 2006.03 29.09 523 13400 4718 2339444
Open reduction of fracture 1976.89 29.09 329 13594 41 2344121
Cataract 1906.15 29.09 515 13408 5393 2338769
Oral infection 1904.85 29.09 363 13560 513 2343649
Jaw disorder 1891.28 29.09 385 13538 916 2343246
Tooth fracture 1851.79 29.09 399 13524 1372 2342790
Adverse event 1773.84 29.09 515 13408 7144 2337018
Hypothyroidism 1764.09 29.09 457 13466 4000 2340162
Rib fracture 1669.94 29.09 393 13530 2192 2341970
Abdominal discomfort 1668.69 29.09 599 13324 16857 2327305
Exostosis 1648.28 29.09 347 13576 1031 2343131
Diverticulum 1601.08 29.09 343 13580 1136 2343026
Anaemia 1563.98 29.09 692 13231 34100 2310062
Hip fracture 1524.63 29.09 412 13511 4300 2339862
Systemic lupus erythematosus 1497.62 29.09 397 13526 3824 2340338
Rheumatoid arthritis 1497.60 29.09 567 13356 18573 2325589
Chest pain 1460.87 29.09 620 13303 27517 2316645
Bone density decreased 1444.72 29.09 311 13612 1059 2343103
Temporomandibular joint syndrome 1435.73 29.09 276 13647 419 2343743
Rotator cuff syndrome 1415.13 29.09 322 13601 1503 2342659
Scoliosis 1398.79 29.09 286 13637 698 2343464
Device failure 1393.29 29.09 316 13607 1449 2342713
Chronic obstructive pulmonary disease 1380.45 29.09 417 13506 6660 2337502
Adverse drug reaction 1378.38 29.09 432 13491 7851 2336311
Urinary tract infection 1368.21 29.09 603 13320 29339 2314823
Pathological fracture 1367.02 29.09 293 13630 971 2343191
Constipation 1363.83 29.09 548 13375 21081 2323081
Tooth abscess 1362.83 29.09 320 13603 1759 2342403
Hiatus hernia 1351.55 29.09 318 13605 1766 2342396
Pain in jaw 1340.19 29.09 398 13525 5974 2338188
Fatigue 1308.49 29.09 824 13099 84049 2260113
Tooth extraction 1272.35 29.09 319 13604 2401 2341761
Fracture delayed union 1250.35 29.09 218 13705 103 2344059
Haemorrhoids 1223.34 29.09 299 13624 1998 2342164
Gingival disorder 1197.31 29.09 236 13687 439 2343723
Drug hypersensitivity 1193.22 29.09 631 13292 46012 2298150
Gastritis 1174.97 29.09 334 13589 4247 2339915
Glossodynia 1168.25 29.09 279 13644 1666 2342496
Spinal compression fracture 1161.06 29.09 275 13648 1576 2342586
Alopecia 1160.77 29.09 491 13432 21510 2322652
Knee arthroplasty 1155.42 29.09 300 13623 2635 2341527
Tooth loss 1137.18 29.09 255 13668 1096 2343066
Insomnia 1133.82 29.09 506 13417 25281 2318881
Intervertebral disc protrusion 1125.61 29.09 296 13627 2745 2341417
Exostosis of jaw 1103.19 29.09 197 13726 135 2344027
Bronchitis 1102.53 29.09 415 13508 13299 2330863
Spondylolisthesis 1076.94 29.09 205 13718 284 2343878
Large intestine polyp 1054.92 29.09 231 13692 867 2343295
Blood loss anaemia 1050.81 29.09 232 13691 913 2343249
Nausea 1025.93 29.09 791 13132 111398 2232764
Musculoskeletal pain 1022.42 29.09 369 13554 10461 2333701
Myalgia 1019.24 29.09 456 13467 22877 2321285
Oral disorder 1000.93 29.09 232 13691 1189 2342973
Gingivitis 1000.93 29.09 232 13691 1189 2342973
Abscess 993.12 29.09 256 13667 2175 2341987
Hip arthroplasty 990.24 29.09 243 13680 1651 2342511
Asthma 980.72 29.09 362 13561 10952 2333210
Oedema peripheral 976.28 29.09 445 13478 23318 2320844
Muscle strain 969.71 29.09 216 13707 893 2343269
Bone loss 969.15 29.09 191 13732 354 2343808
Cellulitis 957.19 29.09 337 13586 8864 2335298
Periodontal disease 956.39 29.09 180 13743 224 2343938
Contusion 944.11 29.09 364 13559 12446 2331716
Lumbar spinal stenosis 939.81 29.09 194 13729 503 2343659
Dysphagia 901.51 29.09 352 13571 12453 2331709
Dyspepsia 901.20 29.09 328 13595 9516 2334646
Joint effusion 896.88 29.09 208 13715 1068 2343094
Ligament sprain 894.53 29.09 213 13710 1250 2342912
Sciatica 883.61 29.09 227 13696 1898 2342264
Wrist fracture 880.09 29.09 217 13706 1506 2342656
Jaw fracture 872.13 29.09 171 13752 304 2343858
Oesophagitis 866.97 29.09 221 13702 1785 2342377
Periodontitis 858.67 29.09 179 13744 495 2343667
Infection 853.09 29.09 373 13550 17656 2326506
Synovial cyst 852.09 29.09 186 13737 684 2343478
Cardiac murmur 843.59 29.09 208 13715 1443 2342719
Drug ineffective 839.63 29.09 676 13247 100948 2243214
Carpal tunnel syndrome 830.62 29.09 214 13709 1811 2342351
Meniscus injury 830.43 29.09 190 13733 908 2343254
Medical device removal 827.15 29.09 164 13759 318 2343844
Muscle spasms 823.14 29.09 384 13539 21182 2322980
Swelling 818.29 29.09 352 13571 15998 2328164
Road traffic accident 801.00 29.09 245 13678 4063 2340099
Spinal stenosis 797.47 29.09 193 13730 1225 2342937
Coronary artery disease 795.27 29.09 263 13660 5676 2338486
Sinusitis 794.98 29.09 346 13577 16180 2327982
Fracture 794.75 29.09 220 13703 2511 2341651
Headache 793.22 29.09 594 13329 79585 2264577
Ankle fracture 792.55 29.09 211 13712 2054 2342108
Dizziness 789.61 29.09 525 13398 58140 2286022
Resorption bone increased 786.74 29.09 141 13782 101 2344061
Foot deformity 785.67 29.09 204 13719 1785 2342377
Gait disturbance 785.47 29.09 377 13546 22168 2321994
Spinal fracture 774.13 29.09 217 13706 2602 2341560
Toothache 764.81 29.09 212 13711 2432 2341730
Calcium deficiency 763.04 29.09 134 13789 71 2344091
Tendonitis 762.81 29.09 204 13719 2023 2342139
Fistula 740.32 29.09 188 13735 1491 2342671
Gingival bleeding 721.62 29.09 192 13731 1863 2342299
Rhinitis allergic 719.26 29.09 158 13765 602 2343560
Bone pain 713.79 29.09 270 13653 8726 2335436
Loose tooth 713.71 29.09 154 13769 528 2343634
Kyphosis 702.27 29.09 136 13787 218 2343944
Cough 699.97 29.09 396 13527 32721 2311441
Internal fixation of fracture 686.02 29.09 124 13799 99 2344063
Hysterectomy 678.58 29.09 175 13748 1485 2342677
Drug intolerance 671.77 29.09 291 13632 13426 2330736
Pneumonia 669.29 29.09 444 13479 48852 2295310
Sleep apnoea syndrome 668.19 29.09 182 13741 1944 2342218
Type 2 diabetes mellitus 667.16 29.09 183 13740 2011 2342151
Gastrointestinal disorder 658.44 29.09 254 13669 8663 2335499
Atrial fibrillation 647.87 29.09 284 13639 13484 2330678
Neck pain 646.82 29.09 241 13682 7456 2336706
Basal cell carcinoma 643.80 29.09 186 13737 2501 2341661
Uterine disorder 640.76 29.09 135 13788 399 2343763
Diarrhoea 640.14 29.09 533 13390 83031 2261131
Tibia fracture 639.67 29.09 145 13778 658 2343504
Irritable bowel syndrome 636.82 29.09 170 13753 1671 2342491
Radiculopathy 636.55 29.09 142 13781 590 2343572
Sinus disorder 635.51 29.09 184 13739 2494 2341668
Weight decreased 631.10 29.09 351 13572 28020 2316142
Joint injury 630.97 29.09 179 13744 2245 2341917
Renal cyst 624.46 29.09 152 13771 990 2343172
Muscular weakness 623.22 29.09 283 13640 14614 2329548
Tooth infection 620.91 29.09 169 13754 1799 2342363
Lumbar radiculopathy 616.64 29.09 119 13804 185 2343977
Humerus fracture 615.18 29.09 150 13773 985 2343177
Cataract operation 612.35 29.09 140 13783 665 2343497
Radius fracture 608.63 29.09 133 13790 491 2343671
Hypokalaemia 601.08 29.09 250 13673 10404 2333758
Spinal disorder 600.61 29.09 149 13774 1061 2343101
Atelectasis 597.88 29.09 164 13759 1801 2342361
Dyspnoea 596.05 29.09 499 13424 78234 2265928
Fibromyalgia 589.11 29.09 182 13741 3118 2341044
Bone graft 580.95 29.09 109 13814 131 2344031
Abdominal pain 573.61 29.09 353 13570 34021 2310141
Lower limb fracture 570.28 29.09 160 13763 1921 2342241
Dyslipidaemia 568.65 29.09 130 13793 617 2343545
Upper respiratory tract infection 568.59 29.09 228 13695 8623 2335539
Ulcer 563.14 29.09 155 13768 1725 2342437
Upper limb fracture 562.30 29.09 168 13755 2555 2341607
Hand deformity 560.52 29.09 138 13785 948 2343214
Urinary incontinence 556.51 29.09 185 13738 4048 2340114
Fibula fracture 549.81 29.09 118 13805 391 2343771
Fibrocystic breast disease 545.59 29.09 104 13819 145 2344017
Herpes zoster 544.45 29.09 227 13696 9498 2334664
Varicose vein 543.57 29.09 126 13797 643 2343519
Hypercalcaemia 539.90 29.09 161 13762 2431 2341731
Mitral valve prolapse 535.69 29.09 111 13812 294 2343868
Limb asymmetry 532.98 29.09 97 13826 84 2344078
Iron deficiency anaemia 532.71 29.09 152 13771 1947 2342215
Appendicectomy 532.42 29.09 115 13808 396 2343766
Osteitis 531.21 29.09 121 13802 563 2343599
Cerumen impaction 529.91 29.09 100 13823 127 2344035
Oral pain 529.80 29.09 169 13754 3228 2340934
Asthenia 526.14 29.09 376 13547 46550 2297612
Pubis fracture 525.96 29.09 108 13815 269 2343893
Stress urinary incontinence 525.32 29.09 107 13816 252 2343910
Pelvic fracture 523.37 29.09 137 13786 1238 2342924
Femoral neck fracture 521.37 29.09 135 13788 1164 2342998
Gastrointestinal haemorrhage 512.81 29.09 234 13689 12201 2331961
Joint swelling 512.42 29.09 257 13666 16562 2327600
Essential hypertension 512.37 29.09 111 13812 389 2343773
Skin laceration 500.18 29.09 153 13770 2529 2341633
Hypoaesthesia 498.53 29.09 268 13655 19947 2324215
Wound 497.62 29.09 153 13770 2575 2341587
Compression fracture 497.38 29.09 121 13802 785 2343377
Nephrolithiasis 496.98 29.09 173 13750 4370 2339792
Migraine 491.92 29.09 217 13706 10436 2333726
Restless legs syndrome 490.10 29.09 145 13778 2126 2342036
Surgery 489.37 29.09 180 13743 5355 2338807
Rash 488.53 29.09 396 13527 59162 2285000
Glaucoma 488.33 29.09 142 13781 1953 2342209
Deep vein thrombosis 482.32 29.09 227 13696 12705 2331457
Aortic arteriosclerosis 481.45 29.09 110 13813 520 2343642
Breast disorder 481.43 29.09 101 13822 290 2343872
Tonsillar disorder 480.65 29.09 92 13831 133 2344029
Hand fracture 480.13 29.09 113 13810 623 2343539
Peptic ulcer 476.14 29.09 108 13815 491 2343671
Neuropathy peripheral 474.07 29.09 216 13707 11216 2332946
Cholecystectomy 472.36 29.09 131 13792 1501 2342661
Limb injury 471.52 29.09 144 13779 2366 2341796
Cyst 470.88 29.09 130 13793 1463 2342699
Inflammation 469.12 29.09 180 13743 6033 2338129
Tonsillectomy 468.59 29.09 93 13830 181 2343981
Acute sinusitis 465.51 29.09 102 13821 382 2343780
Joint dislocation 463.70 29.09 126 13797 1330 2342832
Diverticulum intestinal 462.19 29.09 108 13815 574 2343588
Vomiting 460.51 29.09 414 13509 71188 2272974
Fistula discharge 459.68 29.09 89 13834 142 2344020
Abscess jaw 459.14 29.09 95 13828 249 2343913
Syncope 456.36 29.09 238 13685 16637 2327525
Palpitations 456.23 29.09 236 13687 16220 2327942
Chronic kidney disease 454.97 29.09 158 13765 3960 2340202
Gastric ulcer 453.66 29.09 146 13777 2870 2341292
Rheumatoid nodule 451.35 29.09 104 13819 514 2343648
Appendix disorder 450.04 29.09 87 13836 137 2344025
Atrophic vulvovaginitis 446.49 29.09 85 13838 117 2344045
Emphysema 441.42 29.09 114 13809 971 2343191
Peripheral vascular disorder 440.96 29.09 109 13814 762 2343400
Fracture displacement 440.41 29.09 81 13842 79 2344083
Mitral valve incompetence 439.70 29.09 137 13786 2413 2341749
Cardiac disorder 438.80 29.09 183 13740 7650 2336512
Diabetes mellitus 436.38 29.09 180 13743 7315 2336847
Hyperaesthesia teeth 433.28 29.09 94 13829 332 2343830
Dry mouth 432.90 29.09 184 13739 8069 2336093
Hypersensitivity 428.25 29.09 256 13667 23337 2320825
Mouth ulceration 427.94 29.09 149 13774 3763 2340399
Carotid artery stenosis 419.57 29.09 103 13820 697 2343465
Oral cavity fistula 416.16 29.09 80 13843 120 2344042
Endodontic procedure 415.28 29.09 93 13830 394 2343768
Increased tendency to bruise 414.24 29.09 118 13805 1500 2342662
Haematemesis 414.13 29.09 147 13776 3935 2340227
Back disorder 413.95 29.09 118 13805 1504 2342658
Arteriosclerosis coronary artery 413.51 29.09 110 13813 1063 2343099
Bone lesion 410.32 29.09 98 13825 581 2343581
Edentulous 410.15 29.09 69 13854 13 2344149
Seborrhoeic keratosis 409.35 29.09 86 13837 249 2343913
Ear pain 409.04 29.09 132 13791 2617 2341545
Groin pain 407.44 29.09 112 13811 1238 2342924
Skin abrasion 403.72 29.09 107 13816 1018 2343144
Vertigo 400.62 29.09 181 13742 9203 2334959
Body height decreased 397.99 29.09 108 13815 1133 2343029
Pollakiuria 395.26 29.09 139 13784 3617 2340545
Gallbladder disorder 392.96 29.09 129 13794 2705 2341457
Contraindicated product administered 392.82 29.09 131 13792 2890 2341272
Skin ulcer 392.23 29.09 141 13782 3918 2340244
Paraesthesia 391.27 29.09 236 13687 21852 2322310
Patellofemoral pain syndrome 390.31 29.09 71 13852 61 2344101
Cystocele 382.19 29.09 76 13847 150 2344012
Skin lesion 382.11 29.09 138 13785 3887 2340275
Ulna fracture 379.25 29.09 77 13846 177 2343985
Weight increased 375.99 29.09 231 13692 22106 2322056
Transient ischaemic attack 369.86 29.09 150 13773 5828 2338334
Chronic sinusitis 364.58 29.09 86 13837 479 2343683
Hypertonic bladder 362.08 29.09 80 13843 314 2343848
Gingival pain 361.37 29.09 98 13825 1025 2343137
Sleep disorder 361.33 29.09 151 13772 6338 2337824
Synovitis 357.56 29.09 119 13804 2607 2341555
Musculoskeletal discomfort 352.41 29.09 111 13812 2027 2342135
Exposed bone in jaw 351.66 29.09 90 13833 736 2343426
Dehydration 351.02 29.09 221 13702 22074 2322088
Breast cancer 348.66 29.09 165 13758 9330 2334832
Head injury 348.38 29.09 129 13794 3905 2340257
Cerebrovascular accident 347.96 29.09 212 13711 19974 2324188
Blood parathyroid hormone decreased 347.50 29.09 70 13853 152 2344010
Musculoskeletal chest pain 344.95 29.09 112 13811 2264 2341898
Osteosclerosis 344.10 29.09 75 13848 272 2343890
Fractured sacrum 342.82 29.09 73 13850 230 2343932
Tinnitus 342.39 29.09 136 13787 4999 2339163
Abdominal pain upper 340.25 29.09 216 13707 21884 2322278
Dental fistula 338.70 29.09 65 13858 96 2344066
Abscess oral 338.06 29.09 71 13852 205 2343957
Cardiac failure congestive 337.65 29.09 192 13731 15909 2328253
Granuloma skin 336.80 29.09 62 13861 61 2344101
Cholelithiasis 336.44 29.09 139 13784 5664 2338498
Fungal infection 334.77 29.09 132 13791 4757 2339405
Pulpitis dental 334.41 29.09 65 13858 107 2344055
Intervertebral disc disorder 333.44 29.09 82 13841 559 2343603
Trismus 331.34 29.09 87 13836 795 2343367
Oesophageal ulcer 331.27 29.09 84 13839 659 2343503
Nocturia 330.56 29.09 87 13836 803 2343359
Malaise 330.46 29.09 308 13615 55277 2288885
Device breakage 328.57 29.09 99 13824 1548 2342614
Bruxism 325.68 29.09 83 13840 666 2343496
Bladder disorder 324.41 29.09 90 13833 1031 2343131
Goitre 321.09 29.09 85 13838 804 2343358
Arteriosclerosis 320.93 29.09 95 13828 1393 2342769
Breast mass 318.65 29.09 89 13834 1047 2343115
Haematoma 318.48 29.09 129 13794 4992 2339170
Hyperparathyroidism 317.13 29.09 75 13848 423 2343739
Anaemia of chronic disease 316.47 29.09 66 13857 182 2343980
Vertebral foraminal stenosis 315.69 29.09 59 13864 68 2344094
Angiopathy 315.61 29.09 82 13841 716 2343446
Patella fracture 314.55 29.09 70 13853 286 2343876
Inappropriate schedule of product administration 312.25 29.09 166 13757 12038 2332124
Deafness 311.28 29.09 107 13816 2594 2341568
Hypotension 311.10 29.09 237 13686 32199 2311963
Pyrexia 310.34 29.09 293 13630 53415 2290747
Actinic keratosis 309.28 29.09 70 13853 314 2343848
Stomatitis 309.00 29.09 153 13770 9557 2334605
Balance disorder 308.44 29.09 153 13770 9594 2334568
Peripheral venous disease 307.88 29.09 73 13850 417 2343745
Cardiomegaly 307.88 29.09 103 13820 2293 2341869
Stress 306.11 29.09 137 13786 6801 2337361
Dental implantation 305.42 29.09 65 13858 204 2343958
Diverticulitis 304.72 29.09 118 13805 4047 2340115
Uterine leiomyoma 304.46 29.09 92 13831 1453 2342709
Vitamin B12 deficiency 299.44 29.09 74 13849 516 2343646
Lung disorder 297.69 29.09 130 13793 6082 2338080
Onychomycosis 297.29 29.09 73 13850 494 2343668
Plantar fasciitis 295.65 29.09 70 13853 397 2343765
Left ventricular hypertrophy 295.47 29.09 76 13847 635 2343527
Pneumonia aspiration 295.18 29.09 112 13811 3630 2340532
Nasal septum deviation 293.62 29.09 61 13862 164 2343998
Tenosynovitis stenosans 293.30 29.09 56 13867 79 2344083
Skin cancer 293.11 29.09 92 13831 1659 2342503
Leukocytosis 292.83 29.09 110 13813 3466 2340696
Conjunctivitis 292.18 29.09 99 13824 2294 2341868
Thyroid neoplasm 290.76 29.09 74 13849 590 2343572
Oedema 290.17 29.09 149 13774 10054 2334108
Thyroid disorder 290.04 29.09 89 13834 1484 2342678
Rectocele 289.84 29.09 59 13864 138 2344024
Tendon disorder 289.84 29.09 77 13846 739 2343423
Oral surgery 288.38 29.09 65 13858 285 2343877
Glucose tolerance impaired 287.35 29.09 72 13851 535 2343627
Haematuria 286.57 29.09 114 13809 4204 2339958
Hypoacusis 286.45 29.09 107 13816 3318 2340844
Nodule 283.26 29.09 95 13828 2131 2342031
Multiple fractures 281.91 29.09 72 13851 583 2343579
Seasonal allergy 278.51 29.09 87 13836 1543 2342619
Macular degeneration 276.53 29.09 81 13842 1142 2343020
Gingival recession 276.15 29.09 62 13861 266 2343896
Overdose 275.39 29.09 182 13741 19725 2324437
Vascular calcification 274.10 29.09 55 13868 116 2344046
Lung neoplasm 273.56 29.09 76 13847 875 2343287
Barrett's oesophagus 273.55 29.09 61 13862 252 2343910
Anxiety disorder 273.53 29.09 67 13856 448 2343714
Hyponatraemia 271.49 29.09 156 13767 13169 2330993
Dry eye 271.46 29.09 107 13816 3849 2340313
Carotid bruit 264.26 29.09 51 13872 79 2344083
Rectal haemorrhage 262.67 29.09 117 13806 5739 2338423
Haemoglobin decreased 260.91 29.09 170 13753 17981 2326181
Renal failure 260.48 29.09 167 13756 17182 2326980
Ecchymosis 260.07 29.09 82 13841 1501 2342661
Dental necrosis 259.84 29.09 48 13875 49 2344113
Obesity 258.33 29.09 81 13842 1455 2342707
Eye disorder 256.24 29.09 97 13826 3122 2341040
Colon adenoma 251.76 29.09 55 13868 202 2343960
Osteomyelitis chronic 251.57 29.09 49 13874 82 2344080
Oesophageal stenosis 251.25 29.09 61 13862 391 2343771
Panniculitis 250.96 29.09 63 13860 472 2343690
Gout 250.01 29.09 78 13845 1377 2342785
Removal of internal fixation 249.55 29.09 42 13881 8 2344154
Thoracic vertebral fracture 248.34 29.09 64 13859 539 2343623
Cystitis 247.53 29.09 111 13812 5531 2338631
Trigger finger 246.98 29.09 61 13862 424 2343738
Skeletal injury 245.98 29.09 54 13869 204 2343958
Decreased appetite 244.17 29.09 196 13727 28695 2315467
Myocardial infarction 244.14 29.09 166 13757 18847 2325315
Spinal fusion surgery 242.87 29.09 61 13862 458 2343704
Carotid artery disease 242.16 29.09 54 13869 223 2343939
Injury 241.81 29.09 111 13812 5843 2338319
Dysphonia 237.83 29.09 112 13811 6252 2337910
Lymphadenopathy 236.97 29.09 108 13815 5590 2338572
Periprosthetic fracture 236.21 29.09 44 13879 49 2344113
Spinal laminectomy 236.03 29.09 49 13874 131 2344031
Bunion operation 234.98 29.09 48 13875 115 2344047
Oestrogen deficiency 230.89 29.09 42 13881 36 2344126
Actinomycosis 229.81 29.09 51 13872 205 2343957
Major depression 226.81 29.09 67 13856 974 2343188
Drug eruption 226.57 29.09 89 13834 3170 2340992
Loss of personal independence in daily activities 225.08 29.09 102 13821 5209 2338953
Tenderness 224.93 29.09 77 13846 1841 2342321
Dermatitis contact 224.56 29.09 72 13851 1394 2342768
Blood pressure increased 224.48 29.09 151 13772 16835 2327327
Peripheral swelling 224.38 29.09 153 13770 17444 2326718
Arthroscopy 224.08 29.09 46 13877 114 2344048
Bone fragmentation 223.57 29.09 44 13879 80 2344082
Breast conserving surgery 222.66 29.09 47 13876 140 2344022
Mastication disorder 222.09 29.09 55 13868 387 2343775
Otitis media 221.14 29.09 59 13864 576 2343586
Oedema mouth 221.03 29.09 62 13861 741 2343421
Neuralgia 220.86 29.09 84 13839 2738 2341424
Atrophy 220.63 29.09 52 13871 288 2343874
Bone sequestrum 220.44 29.09 54 13869 361 2343801
Gingival swelling 220.34 29.09 62 13861 750 2343412
Dysuria 220.25 29.09 92 13831 3849 2340313
Myofascial pain syndrome 219.19 29.09 46 13877 132 2344030
Postmenopausal haemorrhage 216.90 29.09 55 13868 431 2343731
Musculoskeletal stiffness 216.90 29.09 131 13792 12116 2332046
Dyspnoea exertional 214.75 29.09 101 13822 5619 2338543
Iliotibial band syndrome 214.41 29.09 37 13886 14 2344148
Hyperglycaemia 213.93 29.09 96 13827 4789 2339373
Foot operation 211.18 29.09 59 13864 694 2343468
Gastric disorder 208.64 29.09 87 13836 3623 2340539
Melanocytic naevus 208.09 29.09 58 13865 676 2343486
Tricuspid valve incompetence 208.00 29.09 70 13853 1586 2342576
Hyperkeratosis 206.71 29.09 59 13864 754 2343408
Pruritus 206.38 29.09 213 13710 43127 2301035
Pharyngitis 205.93 29.09 75 13848 2160 2342002
Mass 205.54 29.09 71 13852 1745 2342417
Oesophageal disorder 205.01 29.09 52 13871 408 2343754
Erythema 204.70 29.09 167 13756 24992 2319170
Skin necrosis 204.28 29.09 63 13860 1068 2343094
Visual impairment 203.69 29.09 124 13799 11631 2332531
Urge incontinence 203.47 29.09 43 13880 129 2344033
Oral herpes 203.29 29.09 74 13849 2128 2342034
Lumbar vertebral fracture 201.94 29.09 58 13865 759 2343403
Eye pain 201.15 29.09 92 13831 4799 2339363
Flank pain 200.76 29.09 67 13856 1478 2342684
Product administration error 200.23 29.09 86 13837 3857 2340305
Vertigo positional 199.97 29.09 49 13874 328 2343834
Hepatic steatosis 199.90 29.09 81 13842 3132 2341030
Epicondylitis 199.60 29.09 46 13877 227 2343935
Angina pectoris 199.31 29.09 86 13837 3901 2340261
Fracture malunion 196.99 29.09 35 13888 22 2344140
Face injury 196.78 29.09 51 13872 440 2343722
Aphthous ulcer 194.28 29.09 64 13859 1354 2342808
Facet joint syndrome 194.19 29.09 38 13885 66 2344096
Staphylococcal infection 193.66 29.09 92 13831 5234 2338928
Electrocardiogram abnormal 193.40 29.09 63 13860 1285 2342877
Breast calcifications 193.35 29.09 44 13879 203 2343959
Acute kidney injury 192.50 29.09 169 13754 27953 2316209
Cervical spinal stenosis 192.04 29.09 46 13877 276 2343886
Atypical fracture 191.85 29.09 40 13883 110 2344052
Breast cyst 191.06 29.09 46 13877 283 2343879
Pulmonary mass 190.07 29.09 68 13855 1858 2342304
Lumbosacral radiculopathy 189.81 29.09 35 13888 35 2344127
Infusion related reaction 189.65 29.09 111 13812 9685 2334477
Dementia 189.11 29.09 74 13849 2607 2341555
Hypoaesthesia oral 188.99 29.09 70 13853 2116 2342046
Maternal exposure during pregnancy 188.89 29.09 129 13794 14734 2329428
Vision blurred 188.05 29.09 128 13795 14540 2329622
Treatment noncompliance 187.29 29.09 91 13832 5443 2338719
Dermal cyst 187.16 29.09 45 13878 275 2343887
Eustachian tube dysfunction 187.04 29.09 37 13886 70 2344092
Tooth deposit 186.48 29.09 35 13888 42 2344120
Micturition urgency 185.47 29.09 60 13863 1196 2342966
Jaw operation 185.29 29.09 43 13880 220 2343942
Rosacea 183.77 29.09 49 13874 477 2343685
Wound dehiscence 183.15 29.09 52 13871 651 2343511
Musculoskeletal disorder 182.63 29.09 71 13852 2457 2341705
Synovial fluid analysis 182.48 29.09 30 13893 1 2344161
Type V hyperlipidaemia 182.22 29.09 35 13888 52 2344110
Sacroiliitis 182.00 29.09 43 13880 241 2343921
Bone metabolism disorder 181.52 29.09 34 13889 40 2344122
Upper gastrointestinal haemorrhage 181.46 29.09 67 13856 2007 2342155
Polyarthritis 180.48 29.09 54 13869 822 2343340
C-reactive protein increased 179.62 29.09 92 13831 6163 2337999
Debridement 179.36 29.09 45 13878 336 2343826
Facial pain 178.31 29.09 59 13864 1266 2342896
Rotator cuff repair 177.95 29.09 41 13882 202 2343960
Melaena 177.57 29.09 80 13843 4026 2340136
Purulent discharge 177.55 29.09 53 13870 800 2343362
Skin disorder 177.17 29.09 77 13846 3554 2340608
Knee deformity 176.70 29.09 38 13885 127 2344035
Hot flush 175.78 29.09 95 13828 7104 2337058
Tenosynovitis 175.22 29.09 47 13876 469 2343693
Rhinitis 175.17 29.09 56 13867 1073 2343089
Vitamin D decreased 174.43 29.09 55 13868 1006 2343156
Acquired oesophageal web 174.31 29.09 33 13890 43 2344119
Gastric ulcer haemorrhage 174.00 29.09 52 13871 788 2343374
Aortic stenosis 173.95 29.09 49 13874 595 2343567
Somnolence 172.55 29.09 147 13776 23338 2320824
Intermittent claudication 171.80 29.09 42 13881 278 2343884
Back injury 171.64 29.09 53 13870 902 2343260
Aspartate aminotransferase increased 171.08 29.09 114 13809 12498 2331664
Periarthritis 170.12 29.09 43 13880 332 2343830
Chest discomfort 169.80 29.09 120 13803 14475 2329687
Purulence 169.11 29.09 43 13880 341 2343821
Anti-cyclic citrullinated peptide antibody positive 168.85 29.09 38 13885 165 2343997
Red blood cell sedimentation rate increased 168.61 29.09 64 13859 2073 2342089
Trigeminal neuralgia 168.47 29.09 48 13875 609 2343553
Vulvovaginal dryness 168.40 29.09 44 13879 393 2343769
Scleritis 168.28 29.09 41 13882 267 2343895
Hepatic cyst 168.04 29.09 48 13875 615 2343547
Hypoxia 165.62 29.09 87 13836 6140 2338022
Dermatitis 165.42 29.09 65 13858 2315 2341847
Periodontal operation 164.98 29.09 28 13895 7 2344155
Upper-airway cough syndrome 164.66 29.09 52 13871 956 2343206
Neoplasm malignant 164.11 29.09 81 13842 5012 2339150
Sjogren's syndrome 164.00 29.09 52 13871 969 2343193
Pulmonary hypertension 163.74 29.09 81 13842 5037 2339125
Deafness neurosensory 163.71 29.09 45 13878 496 2343666
Abdominal hernia 163.56 29.09 46 13877 555 2343607
Night sweats 163.55 29.09 72 13851 3428 2340734
Ear disorder 162.98 29.09 45 13878 505 2343657
Ventricular extrasystoles 162.80 29.09 61 13862 1905 2342257
Bone cyst 162.74 29.09 36 13887 142 2344020
Complication associated with device 162.63 29.09 69 13854 3000 2341162
Oroantral fistula 162.19 29.09 30 13893 31 2344131
Lipoma 161.48 29.09 41 13882 323 2343839
Abdominal distension 160.54 29.09 102 13821 10309 2333853
Nerve injury 159.82 29.09 52 13871 1056 2343106
Oral candidiasis 159.19 29.09 60 13863 1905 2342257
Oropharyngeal pain 158.36 29.09 105 13818 11413 2332749
Bronchitis chronic 157.59 29.09 42 13881 408 2343754
Pulmonary embolism 157.54 29.09 125 13798 17958 2326204
Facial bones fracture 157.51 29.09 44 13879 517 2343645
Polyp 157.42 29.09 46 13877 642 2343520
Squamous cell carcinoma 156.23 29.09 54 13869 1329 2342833
Clavicle fracture 155.69 29.09 42 13881 429 2343733
Hypertensive heart disease 155.27 29.09 41 13882 383 2343779
Tachycardia 155.01 29.09 119 13804 16290 2327872
Erosive oesophagitis 154.47 29.09 38 13885 259 2343903
Kyphoscoliosis 154.42 29.09 29 13894 35 2344127
Raynaud's phenomenon 154.24 29.09 49 13874 919 2343243
Bundle branch block left 153.45 29.09 49 13874 935 2343227
Malnutrition 153.16 29.09 57 13866 1746 2342416
Gastroenteritis 152.91 29.09 66 13857 2994 2341168
Osteoradionecrosis 152.35 29.09 28 13895 27 2344135
Thrombosis 152.09 29.09 94 13829 9050 2335112
Ovarian cyst 151.74 29.09 58 13865 1915 2342247
Hypovolaemia 151.66 29.09 51 13872 1152 2343010
Sequestrectomy 151.54 29.09 38 13885 283 2343879
Swelling face 151.36 29.09 95 13828 9398 2334764
Hernia 151.16 29.09 51 13872 1164 2342998
Supraventricular tachycardia 150.72 29.09 58 13865 1951 2342211
Pleural effusion 149.93 29.09 102 13821 11566 2332596
Aortic valve incompetence 149.64 29.09 47 13876 848 2343314
Jaw cyst 149.04 29.09 27 13896 22 2344140
Panic attack 148.91 29.09 70 13853 3886 2340276
Non-cardiac chest pain 148.90 29.09 46 13877 784 2343378
Pelvic pain 148.84 29.09 57 13866 1892 2342270
Alanine aminotransferase increased 148.64 29.09 109 13814 13923 2330239
Arrhythmia 148.41 29.09 80 13843 5948 2338214
Acetabulum fracture 147.96 29.09 29 13894 51 2344111
Amnesia 147.82 29.09 85 13838 7168 2336994
Comminuted fracture 147.60 29.09 29 13894 52 2344110
Heart rate irregular 146.90 29.09 60 13863 2367 2341795
Pleuritic pain 146.63 29.09 43 13880 608 2343554
Cerebral small vessel ischaemic disease 146.51 29.09 30 13893 73 2344089
Myositis 146.45 29.09 51 13872 1284 2342878
Confusional state 146.25 29.09 136 13787 24208 2319954
Polymyalgia rheumatica 145.42 29.09 40 13883 442 2343720
Cervicobrachial syndrome 144.69 29.09 33 13890 154 2344008
Joint noise 144.00 29.09 42 13881 582 2343580
Hormone level abnormal 143.38 29.09 39 13884 412 2343750
Enthesopathy 142.93 29.09 32 13891 135 2344027
Acrochordon 142.93 29.09 32 13891 135 2344027
Transfusion 142.84 29.09 55 13868 1853 2342309
Carpal tunnel decompression 142.82 29.09 33 13890 165 2343997
Oophorectomy 142.74 29.09 32 13891 136 2344026
Laryngitis 142.57 29.09 51 13872 1392 2342770
Rash pruritic 142.17 29.09 84 13839 7451 2336711
Blood calcium increased 141.91 29.09 49 13874 1202 2342960
Ovarian disorder 141.79 29.09 34 13889 205 2343957
Foreign body 141.78 29.09 39 13884 431 2343731
Epistaxis 141.36 29.09 92 13831 9687 2334475
Crepitations 141.30 29.09 42 13881 624 2343538
Antinuclear antibody positive 140.88 29.09 47 13876 1035 2343127
Rectal polyp 140.59 29.09 31 13892 120 2344042
Cushingoid 140.51 29.09 41 13882 569 2343593
Morton's neuralgia 139.81 29.09 27 13896 42 2344120
Device related infection 139.33 29.09 63 13860 3196 2340966
Pernicious anaemia 139.09 29.09 30 13893 102 2344060
Joint arthroplasty 138.67 29.09 37 13886 361 2343801
Oesophageal carcinoma 137.17 29.09 34 13889 240 2343922
Supraventricular extrasystoles 137.16 29.09 42 13881 694 2343468
Candida infection 137.14 29.09 60 13863 2813 2341349
Flatulence 137.02 29.09 69 13854 4456 2339706
Uterine prolapse 136.50 29.09 33 13890 207 2343955
Helicobacter infection 136.24 29.09 40 13883 568 2343594
Presyncope 136.11 29.09 65 13858 3738 2340424
Haemorrhage 135.92 29.09 94 13829 10945 2333217
Otitis externa 135.79 29.09 32 13891 177 2343985
Pulmonary fibrosis 135.39 29.09 58 13865 2582 2341580
Coma 135.33 29.09 87 13836 8969 2335193
Granuloma 135.02 29.09 40 13883 587 2343575
Sialoadenitis 134.90 29.09 33 13890 219 2343943
Tongue ulceration 134.39 29.09 38 13885 468 2343694
Diastolic dysfunction 134.21 29.09 40 13883 600 2343562
Myocardial ischaemia 133.76 29.09 55 13868 2207 2341955
Nerve compression 133.57 29.09 44 13879 930 2343232
Costochondritis 133.41 29.09 35 13888 318 2343844
Osteomalacia 132.74 29.09 32 13891 198 2343964
Alveolar osteitis 132.36 29.09 27 13896 64 2344098
Condition aggravated 132.29 29.09 146 13777 31833 2312329
Occult blood positive 132.16 29.09 38 13885 499 2343663
Scapula fracture 132.06 29.09 27 13896 65 2344097
Post procedural haemorrhage 131.41 29.09 47 13876 1282 2342880
Discomfort 131.30 29.09 70 13853 5089 2339073
Poor quality sleep 130.67 29.09 52 13871 1915 2342247
Soft tissue disorder 130.21 29.09 32 13891 217 2343945
Aortic aneurysm 129.88 29.09 37 13886 469 2343693
Gingival abscess 129.59 29.09 29 13894 122 2344040
Memory impairment 129.26 29.09 97 13826 12826 2331336
Interstitial lung disease 129.12 29.09 80 13843 7732 2336430
Urinary bladder suspension 129.02 29.09 27 13896 76 2344086
Chondrocalcinosis 128.24 29.09 26 13897 59 2344103
Diabetic neuropathy 128.17 29.09 36 13887 432 2343730
Knee operation 127.98 29.09 42 13881 877 2343285
Gastritis erosive 127.92 29.09 41 13882 792 2343370
Wheezing 127.91 29.09 74 13849 6310 2337852
Bundle branch block right 127.10 29.09 41 13882 809 2343353
Dental plaque 126.88 29.09 24 13899 31 2344131
Urinary retention 126.15 29.09 61 13862 3606 2340556
Osteogenesis imperfecta 125.79 29.09 25 13898 49 2344113
Spondylitis 124.99 29.09 33 13890 308 2343854
Nasal disorder 124.99 29.09 33 13890 308 2343854
Shoulder arthroplasty 124.92 29.09 34 13889 360 2343802
Clostridium difficile colitis 124.47 29.09 51 13872 2028 2342134
Incisional drainage 123.18 29.09 27 13896 101 2344061
Abdominal pain lower 123.17 29.09 56 13867 2877 2341285
Bladder prolapse 123.02 29.09 31 13892 236 2343926
Sinus tachycardia 122.57 29.09 58 13865 3267 2340895
Decubitus ulcer 122.54 29.09 45 13878 1326 2342836
Haematocrit decreased 122.46 29.09 63 13860 4255 2339907
Biopsy bone 121.95 29.09 22 13901 17 2344145
Haematochezia 121.27 29.09 67 13856 5228 2338934
Osteomyelitis acute 121.11 29.09 24 13899 46 2344116
Uterine polyp 120.77 29.09 33 13890 355 2343807
Hyperthyroidism 120.65 29.09 50 13873 2047 2342115
Skin papilloma 120.48 29.09 36 13887 545 2343617
Closed fracture manipulation 120.39 29.09 20 13903 2 2344160
Osteolysis 120.37 29.09 34 13889 417 2343745
Biopsy breast 120.36 29.09 25 13898 67 2344095
Phlebolith 120.32 29.09 22 13901 20 2344142
Renal disorder 120.17 29.09 63 13860 4425 2339737
Incontinence 119.96 29.09 45 13878 1409 2342753
Intervertebral disc space narrowing 119.96 29.09 26 13897 91 2344071
Joint range of motion decreased 119.59 29.09 48 13875 1808 2342354
Adenoidal disorder 119.58 29.09 21 13902 11 2344151
Post laminectomy syndrome 118.32 29.09 22 13901 24 2344138
Mental status changes 117.97 29.09 67 13856 5515 2338647
Post procedural fever 116.46 29.09 24 13899 61 2344101
Duodenal ulcer perforation 116.04 29.09 31 13892 304 2343858
Intraocular lens implant 115.63 29.09 24 13899 64 2344098
Liver function test abnormal 114.49 29.09 73 13850 7417 2336745
Blood disorder 114.33 29.09 39 13884 921 2343241
Colitis 113.88 29.09 64 13859 5162 2339000
Limb deformity 112.84 29.09 29 13894 241 2343921
Limb discomfort 112.60 29.09 55 13868 3324 2340838
Subcutaneous abscess 111.61 29.09 38 13885 892 2343270
Blood glucose increased 111.38 29.09 87 13836 12203 2331959
Post-traumatic stress disorder 109.46 29.09 32 13891 447 2343715
Eczema 109.30 29.09 53 13870 3152 2341010
Ocular hyperaemia 108.77 29.09 57 13866 3999 2340163
Blister 108.50 29.09 68 13855 6703 2337459
Concussion 108.21 29.09 37 13886 880 2343282
Benign neoplasm 107.53 29.09 25 13898 129 2344033
Hydronephrosis 107.40 29.09 40 13883 1227 2342935
Rheumatoid factor positive 107.36 29.09 32 13891 480 2343682
Cerebrovascular disorder 106.99 29.09 33 13890 559 2343603
Stasis dermatitis 106.12 29.09 24 13899 107 2344055
Postoperative wound infection 105.95 29.09 39 13884 1157 2343005
Gastric polyps 105.62 29.09 29 13894 318 2343844
Hypocalcaemia 105.36 29.09 55 13868 3828 2340334
Radicular pain 105.36 29.09 23 13900 84 2344078
Bacterial infection 104.75 29.09 46 13877 2175 2341987
Medical device pain 104.67 29.09 27 13896 228 2343934
Cervical dysplasia 104.55 29.09 34 13889 689 2343473
Feeling jittery 104.22 29.09 44 13879 1888 2342274
Lacunar infarction 104.11 29.09 33 13890 614 2343548
Viral infection 103.89 29.09 58 13865 4618 2339544
Labyrinthitis 103.63 29.09 29 13894 343 2343819
Eating disorder 103.57 29.09 46 13877 2235 2341927
Uterine dilation and curettage 103.44 29.09 27 13896 240 2343922
Photophobia 103.42 29.09 46 13877 2243 2341919
Radiotherapy 103.37 29.09 24 13899 123 2344039
Inflammatory bowel disease 103.26 29.09 32 13891 551 2343611
Menopausal symptoms 103.24 29.09 29 13894 348 2343814
Peripheral arterial occlusive disease 102.94 29.09 32 13891 557 2343605
Ligament rupture 102.91 29.09 31 13892 483 2343679
Oral fibroma 102.78 29.09 18 13905 9 2344153
Blood calcium decreased 102.77 29.09 45 13878 2113 2342049
Neck injury 102.74 29.09 28 13895 298 2343864
Vitreous detachment 102.71 29.09 29 13894 355 2343807
Tremor 102.56 29.09 104 13819 20557 2323605
Osteoma 102.54 29.09 19 13904 20 2344142
Pancreatitis 102.26 29.09 70 13853 8009 2336153
Mammogram abnormal 102.25 29.09 24 13899 130 2344032
Drug tolerance decreased 102.16 29.09 27 13896 253 2343909
Hypoglycaemia 102.08 29.09 71 13852 8336 2335826
Menopause 101.98 29.09 28 13895 307 2343855
Malocclusion 101.74 29.09 20 13903 36 2344126
Neuroma 101.28 29.09 22 13901 78 2344084
Hypertriglyceridaemia 101.25 29.09 35 13888 861 2343301
Adenotonsillectomy 101.13 29.09 19 13904 23 2344139
Neuritis 101.03 29.09 25 13898 175 2343987
Breast pain 100.76 29.09 39 13884 1332 2342830
Eyelid ptosis 100.40 29.09 37 13886 1101 2343061
Mastectomy 100.32 29.09 27 13896 273 2343889
Limb operation 100.13 29.09 31 13892 532 2343630
Peroneal nerve palsy 99.84 29.09 33 13890 705 2343457
Visual acuity reduced 99.76 29.09 59 13864 5239 2338923
Postmenopause 99.72 29.09 18 13905 14 2344148
Benign breast neoplasm 99.47 29.09 25 13898 188 2343974
Liver disorder 99.23 29.09 63 13860 6351 2337811
Intestinal polyp 98.93 29.09 24 13899 153 2344009
Haemangioma 98.88 29.09 29 13894 410 2343752
Odynophagia 98.46 29.09 35 13888 937 2343225
Periostitis 98.38 29.09 21 13902 67 2344095
Vaginal infection 97.17 29.09 34 13889 868 2343294
Sinus bradycardia 97.13 29.09 43 13880 2073 2342089
Persistent depressive disorder 96.72 29.09 23 13900 133 2344029
Steroid therapy 96.72 29.09 19 13904 34 2344128
Cerebral atrophy 96.39 29.09 33 13890 788 2343374
Vaginal disorder 96.38 29.09 24 13899 173 2343989
Spinal operation 96.19 29.09 33 13890 793 2343369
Perineurial cyst 96.10 29.09 17 13906 10 2344152
Sinus congestion 96.05 29.09 42 13881 1965 2342197
Respiratory failure 95.84 29.09 83 13840 13445 2330717
Nervousness 95.65 29.09 57 13866 5132 2339030
Dementia Alzheimer's type 95.42 29.09 33 13890 813 2343349
Animal bite 94.94 29.09 28 13895 404 2343758
Muscle atrophy 94.86 29.09 35 13888 1045 2343117
Emotional distress 94.67 29.09 53 13870 4242 2339920
Bladder repair 94.37 29.09 19 13904 41 2344121
Avulsion fracture 93.75 29.09 19 13904 43 2344119
Impaired work ability 93.58 29.09 40 13883 1770 2342392
Wound drainage 93.45 29.09 23 13900 157 2344005
Bronchial hyperreactivity 93.43 29.09 24 13899 199 2343963
Nasopharyngitis 93.39 29.09 102 13821 21954 2322208
Hyperparathyroidism primary 93.18 29.09 20 13903 66 2344096
Adhesion 92.95 29.09 25 13898 252 2343910
Treatment failure 92.28 29.09 63 13860 7176 2336986
Blepharitis 92.03 29.09 28 13895 452 2343710
Blood potassium decreased 91.91 29.09 56 13867 5249 2338913
Spinal deformity 91.74 29.09 23 13900 171 2343991
Bone formation decreased 91.70 29.09 18 13905 32 2344130
Bipolar disorder 91.59 29.09 36 13887 1282 2342880
Packed red blood cell transfusion 91.48 29.09 25 13898 269 2343893
Ear infection 91.25 29.09 48 13875 3393 2340769
Osteoporotic fracture 90.58 29.09 26 13897 339 2343823
Urticaria 90.44 29.09 105 13818 24156 2320006
Duodenitis 90.25 29.09 28 13895 484 2343678
Nasal congestion 89.69 29.09 61 13862 6905 2337257
Cardiovascular disorder 89.62 29.09 42 13881 2313 2341849
Cataract nuclear 89.43 29.09 21 13902 114 2344048
Vertebroplasty 89.40 29.09 19 13904 59 2344103
Lymphoedema 89.26 29.09 34 13889 1111 2343051
Dental prosthesis placement 89.04 29.09 18 13905 40 2344122
Joint contracture 88.87 29.09 23 13900 197 2343965
Metastatic neoplasm 88.64 29.09 30 13893 691 2343471
Impaired fasting glucose 88.60 29.09 17 13906 25 2344137
Dental alveolar anomaly 88.60 29.09 17 13906 25 2344137
Oral discomfort 88.47 29.09 35 13888 1268 2342894
Complex regional pain syndrome 88.47 29.09 25 13898 307 2343855
Post-traumatic neck syndrome 88.23 29.09 21 13902 122 2344040
Gingival ulceration 87.94 29.09 22 13901 162 2344000
Dysgeusia 87.92 29.09 65 13858 8394 2335768
Glossitis 87.88 29.09 28 13895 530 2343632
Spondylolysis 87.27 29.09 16 13907 15 2344147
Procedural hypotension 87.08 29.09 23 13900 215 2343947
Bone marrow oedema 86.82 29.09 21 13902 132 2344030
Osteopetrosis 86.68 29.09 15 13908 6 2344156
Haemorrhoid operation 86.45 29.09 18 13905 49 2344113
Tooth discolouration 86.37 29.09 24 13899 276 2343886
Thrombocytopenia 85.41 29.09 91 13832 19040 2325122
Blood triglycerides increased 85.35 29.09 40 13883 2203 2341959
Loss of consciousness 85.08 29.09 90 13833 18677 2325485
Coccydynia 84.99 29.09 21 13902 146 2344016
Traumatic fracture 84.65 29.09 20 13903 112 2344050
Herpes simplex 84.31 29.09 32 13891 1035 2343127
Therapeutic product effect decreased 84.21 29.09 70 13853 10719 2333443
Hyperkalaemia 84.05 29.09 55 13868 5838 2338324
Hypercalciuria 83.27 29.09 18 13905 62 2344100
Seizure 83.13 29.09 101 13822 24365 2319797
Salpingo-oophorectomy bilateral 82.83 29.09 17 13906 42 2344120
Small intestinal obstruction 82.65 29.09 39 13884 2181 2341981
Post procedural infection 82.64 29.09 32 13891 1094 2343068
Asphyxia 82.56 29.09 31 13892 973 2343189
Hepatic enzyme increased 81.54 29.09 66 13857 9736 2334426
Meniscus removal 81.34 29.09 15 13908 15 2344147
Oesophageal haemorrhage 81.07 29.09 20 13903 138 2344024
Cerebral ischaemia 80.92 29.09 32 13891 1158 2343004
Dupuytren's contracture 80.57 29.09 18 13905 75 2344087
Cartilage injury 80.14 29.09 22 13901 241 2343921
Atrioventricular block first degree 80.03 29.09 30 13893 937 2343225
Tooth impacted 79.94 29.09 17 13906 53 2344109
Breath odour 79.81 29.09 22 13901 245 2343917
Parathyroid tumour benign 79.50 29.09 20 13903 151 2344011
Cholecystitis 79.27 29.09 38 13885 2202 2341960
Tubulointerstitial nephritis 79.18 29.09 39 13884 2399 2341763
Diabetes mellitus inadequate control 79.13 29.09 36 13887 1851 2342311
Squamous cell carcinoma of skin 79.00 29.09 28 13895 743 2343419
Chondromalacia 78.99 29.09 17 13906 57 2344105
Retinal detachment 78.23 29.09 31 13892 1128 2343034
Enterocele 78.20 29.09 15 13908 22 2344140
Chondrocalcinosis pyrophosphate 78.05 29.09 20 13903 164 2343998
Metatarsalgia 77.54 29.09 16 13907 41 2344121
Presbyopia 77.46 29.09 17 13906 64 2344098
Oesophageal ulcer haemorrhage 77.46 29.09 17 13906 64 2344098
Sepsis 77.38 29.09 85 13838 18403 2325759
Palatal disorder 76.92 29.09 18 13905 96 2344066
Incisional hernia 76.75 29.09 21 13902 227 2343935
Bone formation increased 76.72 29.09 16 13907 44 2344118
Normochromic normocytic anaemia 76.59 29.09 27 13896 705 2343457
Umbilical hernia 76.55 29.09 23 13900 355 2343807
Eye irritation 76.48 29.09 43 13880 3469 2340693
Ureterolithiasis 76.42 29.09 22 13901 290 2343872
Joint stiffness 76.25 29.09 45 13878 3978 2340184
Pericarditis 76.21 29.09 33 13890 1507 2342655
Fibroma 75.85 29.09 18 13905 103 2344059
Epigastric discomfort 75.85 29.09 25 13898 529 2343633
Aortic disorder 75.56 29.09 18 13905 105 2344057
Inguinal hernia 75.37 29.09 21 13902 244 2343918
Left atrial dilatation 75.30 29.09 21 13902 245 2343917
Influenza 74.96 29.09 71 13852 12907 2331255
Pyelonephritis 74.79 29.09 36 13887 2105 2342057
Fibrosis 74.75 29.09 24 13899 466 2343696
Haemorrhoidal haemorrhage 74.56 29.09 25 13898 559 2343603
Procedural haemorrhage 74.37 29.09 24 13899 474 2343688
Malignant melanoma 74.18 29.09 35 13888 1957 2342205
Hypoparathyroidism 74.16 29.09 18 13905 115 2344047
Sinus node dysfunction 74.14 29.09 26 13897 668 2343494
Weight bearing difficulty 73.79 29.09 23 13900 404 2343758
Dyspareunia 73.79 29.09 23 13900 404 2343758
Nodal osteoarthritis 73.73 29.09 17 13906 84 2344078
Generalised anxiety disorder 73.62 29.09 20 13903 210 2343952
Urinary tract disorder 73.57 29.09 23 13900 408 2343754
Hyperhidrosis 73.55 29.09 76 13847 15346 2328816
Iron deficiency 73.53 29.09 25 13898 584 2343578
Hernia repair 73.22 29.09 21 13902 273 2343889
Senile osteoporosis 73.20 29.09 14 13909 20 2344142
Oesophageal perforation 73.07 29.09 17 13906 88 2344074
Chills 73.01 29.09 76 13847 15476 2328686
Cardiac valve disease 73.00 29.09 26 13897 700 2343462
Sinus headache 72.98 29.09 28 13895 933 2343229
Lung infiltration 72.88 29.09 36 13887 2228 2341934
Gouty arthritis 72.59 29.09 17 13906 91 2344071
Leukoplakia 72.54 29.09 15 13908 39 2344123
Scar 72.36 29.09 34 13889 1883 2342279
Chondropathy 72.26 29.09 22 13901 356 2343806
Bradycardia 72.22 29.09 62 13861 9919 2334243
Tongue disorder 72.19 29.09 29 13894 1094 2343068
Cervical radiculopathy 72.13 29.09 17 13906 94 2344068
Gastroenteritis viral 71.92 29.09 37 13886 2497 2341665
Sinus operation 71.74 29.09 20 13903 233 2343929
Mixed incontinence 71.65 29.09 14 13909 24 2344138
Skin infection 71.52 29.09 31 13892 1419 2342743
Joint instability 71.51 29.09 19 13904 182 2343980
Forearm fracture 71.39 29.09 17 13906 99 2344063
Focal segmental glomerulosclerosis 71.27 29.09 20 13903 239 2343923
Vaginal prolapse 71.24 29.09 17 13906 100 2344062
Tympanic membrane perforation 70.97 29.09 20 13903 243 2343919
Varicose vein operation 70.93 29.09 14 13909 26 2344136
Fibroadenoma of breast 70.67 29.09 17 13906 104 2344058
Phlebitis 70.65 29.09 28 13895 1019 2343143
Mobility decreased 70.50 29.09 58 13865 8752 2335410
Coagulopathy 69.88 29.09 38 13885 2871 2341291
Arthrodesis 69.39 29.09 19 13904 206 2343956
Blindness unilateral 69.21 29.09 29 13894 1220 2342942
Hip surgery 69.20 29.09 23 13900 500 2343662
Muscle injury 69.17 29.09 20 13903 268 2343894
Reflux laryngitis 68.98 29.09 14 13909 32 2344130
Hypomagnesaemia 68.64 29.09 36 13887 2528 2341634
Mental disorder 68.64 29.09 42 13881 3965 2340197
Oesophageal spasm 68.56 29.09 20 13903 277 2343885
Escherichia urinary tract infection 68.44 29.09 29 13894 1255 2342907
Cardiac pacemaker insertion 68.31 29.09 25 13898 729 2343433
Necrosis 68.30 29.09 27 13896 976 2343186
Oesophageal discomfort 68.24 29.09 15 13908 57 2344105
Post procedural constipation 68.21 29.09 13 13910 18 2344144
Cervical vertebral fracture 68.01 29.09 21 13902 357 2343805
Fear 67.96 29.09 36 13887 2580 2341582
Poor dental condition 67.81 29.09 14 13909 36 2344126
Abscess neck 67.51 29.09 16 13907 91 2344071
Blood alkaline phosphatase increased 67.35 29.09 50 13873 6495 2337667
Blindness 67.34 29.09 40 13883 3578 2340584
Osteochondrosis 67.32 29.09 18 13905 177 2343985
Product use issue 67.29 29.09 65 13858 12104 2332058
Dermatitis allergic 67.17 29.09 33 13890 2018 2342144
Electrocardiogram ST-T change 66.61 29.09 18 13905 185 2343977
Loose body in joint 66.48 29.09 14 13909 41 2344121
Pseudarthrosis 66.30 29.09 15 13908 67 2344095
Joint surgery 65.94 29.09 15 13908 69 2344093
Hypergammaglobulinaemia benign monoclonal 65.55 29.09 16 13907 105 2344057
Haemarthrosis 65.54 29.09 21 13902 405 2343757
Muscle disorder 65.39 29.09 25 13898 825 2343337
Traumatic ulcer 65.07 29.09 12 13911 12 2344150
Wound infection 64.94 29.09 28 13895 1265 2342897
Neoplasm 64.89 29.09 27 13896 1116 2343046
Orthostatic hypotension 64.73 29.09 36 13887 2843 2341319
Haemangioma of liver 64.62 29.09 18 13905 209 2343953
Lichen planus 64.13 29.09 21 13902 435 2343727
Coronary arterial stent insertion 64.13 29.09 23 13900 632 2343530
Connective tissue disorder 64.00 29.09 18 13905 217 2343945
Meralgia paraesthetica 63.96 29.09 13 13910 30 2344132
Post procedural complication 63.86 29.09 36 13887 2918 2341244
Dental discomfort 63.79 29.09 15 13908 82 2344080
Tendon rupture 63.78 29.09 29 13894 1489 2342673
Restrictive pulmonary disease 63.69 29.09 17 13906 166 2343996
Bone erosion 63.53 29.09 22 13901 544 2343618
Fractured coccyx 63.51 29.09 17 13906 168 2343994
Functional gastrointestinal disorder 63.51 29.09 21 13902 449 2343713
Sternal fracture 63.42 29.09 17 13906 169 2343993
Respiratory tract infection 63.37 29.09 40 13883 3989 2340173
Ingrowing nail 63.37 29.09 19 13904 291 2343871
Cardiometabolic syndrome 63.33 29.09 18 13905 226 2343936
Abnormal loss of weight 63.12 29.09 23 13900 662 2343500
Osteitis deformans 62.92 29.09 14 13909 57 2344105
Adenoma benign 62.79 29.09 16 13907 128 2344034
Family stress 62.57 29.09 16 13907 130 2344032
Astigmatism 62.57 29.09 16 13907 130 2344032
Grief reaction 62.53 29.09 14 13909 59 2344103
Craniocerebral injury 62.45 29.09 20 13903 385 2343777
Autoimmune thyroiditis 62.38 29.09 22 13901 575 2343587
Coeliac disease 62.32 29.09 24 13899 808 2343354
Endometriosis 62.04 29.09 23 13900 696 2343466
Facial paralysis 62.03 29.09 33 13890 2386 2341776
Ilium fracture 61.75 29.09 13 13910 38 2344124
Thyroidectomy 61.37 29.09 17 13906 193 2343969
Iodine allergy 61.25 29.09 13 13910 40 2344122
Metastases to bone 61.15 29.09 32 13891 2237 2341925
Parkinson's disease 61.03 29.09 27 13896 1299 2342863
Arthropod bite 60.95 29.09 25 13898 996 2343166
Cervical polyp 60.75 29.09 14 13909 69 2344093
Tension headache 60.57 29.09 21 13902 521 2343641
Shoulder operation 60.26 29.09 19 13904 347 2343815
Artificial crown procedure 60.25 29.09 14 13909 72 2344090
Carotid arteriosclerosis 60.24 29.09 16 13907 153 2344009
Hormone therapy 60.19 29.09 10 13913 1 2344161
Polypectomy 60.01 29.09 15 13908 110 2344052
Device dislocation 59.87 29.09 36 13887 3292 2340870
Fluid retention 59.77 29.09 48 13875 6998 2337164
Cystitis interstitial 59.70 29.09 17 13906 215 2343947
Snoring 59.52 29.09 20 13903 450 2343712
Bone scan abnormal 59.46 29.09 14 13909 77 2344085
Parathyroid disorder 59.42 29.09 15 13908 115 2344047
Rhinorrhoea 59.22 29.09 49 13874 7451 2336711
Vulvovaginal candidiasis 59.22 29.09 19 13904 368 2343794
Impaired gastric emptying 59.16 29.09 24 13899 929 2343233
Oral discharge 59.02 29.09 13 13910 50 2344112
Lip and/or oral cavity cancer 58.86 29.09 15 13908 120 2344042
Abscess limb 58.83 29.09 21 13902 569 2343593
Pleurisy 58.72 29.09 26 13897 1253 2342909
Ankle operation 58.56 29.09 16 13907 172 2343990
Dental prosthesis user 58.37 29.09 12 13911 30 2344132
Medical device implantation 58.29 29.09 14 13909 85 2344077
Procedural nausea 58.21 29.09 15 13908 126 2344036
Temperature intolerance 58.11 29.09 24 13899 973 2343189
Colon cancer 57.97 29.09 29 13894 1844 2342318
Feeling abnormal 57.86 29.09 83 13840 23498 2320664
Herpes virus infection 57.62 29.09 23 13900 853 2343309
Acute respiratory failure 57.62 29.09 34 13889 3004 2341158
Spinal pain 57.47 29.09 26 13897 1319 2342843
Bone contusion 57.47 29.09 13 13910 58 2344104
Wound secretion 57.45 29.09 21 13902 610 2343552
Lipids increased 57.40 29.09 17 13906 249 2343913
Appendicitis 57.40 29.09 25 13898 1158 2343004
Blood urea increased 57.22 29.09 36 13887 3569 2340593
Benign neoplasm of thyroid gland 57.19 29.09 15 13908 136 2344026
Myopathy 57.11 29.09 27 13896 1516 2342646
Parathyroidectomy 57.08 29.09 14 13909 94 2344068
Seroma 56.90 29.09 17 13906 257 2343905
Ileus 56.73 29.09 30 13893 2142 2342020
Hypophosphataemia 56.48 29.09 24 13899 1046 2343116
Nasal polyps 56.36 29.09 16 13907 200 2343962
Tooth injury 56.21 29.09 16 13907 202 2343960
Pulmonary granuloma 56.21 29.09 16 13907 202 2343960
Neck mass 56.13 29.09 18 13905 348 2343814
Multiple injuries 55.84 29.09 17 13906 275 2343887
Carotid artery occlusion 55.83 29.09 19 13904 445 2343717
Benign neoplasm of skin 55.81 29.09 12 13911 40 2344122
Overweight 55.79 29.09 19 13904 446 2343716
Gait inability 55.75 29.09 43 13880 5912 2338250
Fallopian tube disorder 55.58 29.09 12 13911 41 2344121
Soft tissue injury 55.50 29.09 14 13909 107 2344055
Extraskeletal ossification 55.19 29.09 11 13912 22 2344140
Change of bowel habit 55.09 29.09 16 13907 218 2343944
Hepatic function abnormal 54.89 29.09 43 13880 6049 2338113
Urethral caruncle 54.73 29.09 10 13913 9 2344153
Mouth haemorrhage 54.46 29.09 23 13900 987 2343175
Gene mutation 54.42 29.09 15 13908 167 2343995
Aortic valve sclerosis 54.34 29.09 15 13908 168 2343994
Extrasystoles 54.26 29.09 23 13900 996 2343166
Smear cervix abnormal 54.25 29.09 17 13906 304 2343858
Enchondromatosis 54.24 29.09 11 13912 25 2344137
Renal impairment 54.09 29.09 53 13870 10039 2334123
Delirium 53.96 29.09 40 13883 5183 2338979
Dry skin 53.65 29.09 44 13879 6608 2337554
Adenoidectomy 53.65 29.09 11 13912 27 2344135
Oral fungal infection 53.57 29.09 18 13905 405 2343757
Diplopia 53.49 29.09 34 13889 3431 2340731
Heart rate increased 53.43 29.09 55 13868 11050 2333112
Laryngeal pain 53.41 29.09 23 13900 1036 2343126
Throat irritation 53.04 29.09 39 13884 4991 2339171
QRS axis abnormal 53.02 29.09 15 13908 185 2343977
Colitis microscopic 52.76 29.09 22 13901 914 2343248
External fixation of fracture 52.44 29.09 9 13914 3 2344159
Drug dependence 52.36 29.09 32 13891 3013 2341149
Thermal burn 52.15 29.09 21 13902 797 2343365
Spinal cord disorder 51.88 29.09 15 13908 201 2343961
Disability 51.81 29.09 21 13902 811 2343351
Eyelid disorder 51.76 29.09 16 13907 273 2343889
Cholecystitis acute 51.62 29.09 23 13900 1125 2343037
Blood urine present 51.62 29.09 27 13896 1885 2342277
Tracheobronchitis 51.62 29.09 14 13909 146 2344016
Respiratory tract congestion 51.50 29.09 29 13894 2345 2341817
Sinus polyp 51.44 29.09 12 13911 63 2344099
Oesophagitis haemorrhagic 51.44 29.09 12 13911 63 2344099
Dental care 51.39 29.09 17 13906 364 2343798
Procedural pain 51.21 29.09 26 13897 1706 2342456
Wound infection staphylococcal 51.12 29.09 17 13906 370 2343792
Hip deformity 51.08 29.09 11 13912 37 2344125
Gastrointestinal melanosis 51.08 29.09 11 13912 37 2344125
Bladder operation 51.03 29.09 14 13909 153 2344009
Azotaemia 50.90 29.09 19 13904 586 2343576
Labile hypertension 50.82 29.09 12 13911 67 2344095
Large intestinal polypectomy 50.64 29.09 11 13912 39 2344123
Acute myocardial infarction 50.63 29.09 38 13885 5017 2339145
Rhinitis perennial 50.44 29.09 9 13914 6 2344156
Neurectomy 50.44 29.09 9 13914 6 2344156
Temporal arteritis 50.40 29.09 16 13907 299 2343863
Red blood cell sedimentation rate 50.18 29.09 10 13913 20 2344142
Genital herpes 50.15 29.09 16 13907 304 2343858
Respiratory distress 50.13 29.09 38 13885 5091 2339071
Gastrointestinal tract adenoma 50.08 29.09 12 13911 72 2344090
Obstruction gastric 49.99 29.09 14 13909 166 2343996
Myositis ossificans 49.86 29.09 9 13914 7 2344155
Macrocytosis 49.65 29.09 15 13908 236 2343926
Libido decreased 49.57 29.09 18 13905 513 2343649
Poor personal hygiene 49.53 29.09 12 13911 76 2344086
Adjustment disorder 49.46 29.09 14 13909 173 2343989
Bronchiectasis 48.89 29.09 21 13902 940 2343222
Pelvic prolapse 48.82 29.09 11 13912 48 2344114
Eye infection 48.82 29.09 23 13900 1281 2342881
Cyst removal 48.74 29.09 12 13911 82 2344080
Duodenal ulcer 48.72 29.09 22 13901 1111 2343051
Renal artery stenosis 48.68 29.09 15 13908 253 2343909
Post herpetic neuralgia 48.52 29.09 15 13908 256 2343906
Speech disorder 48.48 29.09 41 13882 6423 2337739
Nephropathy 48.44 29.09 20 13903 810 2343352
Incorrect dose administered 48.42 29.09 49 13874 9646 2334516
Pyogenic granuloma 48.37 29.09 12 13911 85 2344077
Bone neoplasm 48.33 29.09 13 13910 131 2344031
Hypertrophy 48.25 29.09 12 13911 86 2344076
Aspiration 48.21 29.09 24 13899 1510 2342652
Intervertebral disc displacement 48.12 29.09 12 13911 87 2344075
Spinal decompression 47.93 29.09 11 13912 53 2344109
Bone infarction 47.89 29.09 12 13911 89 2344073
Malpositioned teeth 47.85 29.09 9 13914 11 2344151
Mandibular mass 47.82 29.09 10 13913 28 2344134
Lordosis 47.82 29.09 10 13913 28 2344134
Mitral valve disease 47.79 29.09 16 13907 356 2343806
Cheilitis 47.78 29.09 20 13903 839 2343323
Bacterial vulvovaginitis 47.64 29.09 13 13910 139 2344023
Spinal cord compression 47.42 29.09 18 13905 582 2343580
Gastrointestinal inflammation 47.34 29.09 19 13904 715 2343447
Leukoplakia oral 47.27 29.09 11 13912 57 2344105
Intraductal proliferative breast lesion 47.12 29.09 16 13907 372 2343790
Paraesthesia oral 47.01 29.09 27 13896 2267 2341895
Bone marrow disorder 47.00 29.09 16 13907 375 2343787
Oesophageal pain 46.84 29.09 16 13907 379 2343783
Urine calcium increased 46.82 29.09 10 13913 32 2344130
Mouth cyst 46.82 29.09 10 13913 32 2344130
Intervertebral disc operation 46.82 29.09 13 13910 149 2344013
Respiratory disorder 46.68 29.09 33 13890 3971 2340191
Traumatic occlusion 46.37 29.09 8 13915 3 2344159
Allergy to arthropod sting 46.36 29.09 10 13913 34 2344128
Tracheo-oesophageal fistula 46.34 29.09 12 13911 103 2344059
Thyroid cyst 46.24 29.09 12 13911 104 2344058
Spinal claudication 46.22 29.09 9 13914 15 2344147
Post procedural haematoma 46.07 29.09 15 13908 305 2343857
Breast hyperplasia 46.05 29.09 11 13912 65 2344097
Breast operation 46.03 29.09 12 13911 106 2344056
Neurodermatitis 45.61 29.09 13 13910 165 2343997
Dysaesthesia 45.52 29.09 18 13905 651 2343511
Macular hole 45.50 29.09 14 13909 235 2343927
Pancreatitis acute 45.49 29.09 32 13891 3821 2340341
Lung hyperinflation 45.44 29.09 12 13911 112 2344050
Incision site haematoma 45.29 29.09 10 13913 39 2344123
Vitreous floaters 45.26 29.09 20 13903 959 2343203
Spinal column injury 45.23 29.09 14 13909 240 2343922
Hepatitis 45.09 29.09 39 13884 6298 2337864
Mycotic allergy 45.08 29.09 10 13913 40 2344122
Mammoplasty 45.06 29.09 12 13911 116 2344046
Eructation 45.06 29.09 21 13902 1141 2343021
Rhinoplasty 45.04 29.09 8 13915 5 2344157
Essential tremor 44.88 29.09 12 13911 118 2344044
Diabetic retinopathy 44.83 29.09 15 13908 333 2343829
Inguinal hernia repair 44.52 29.09 9 13914 20 2344142
Pneumothorax 44.17 29.09 26 13897 2286 2341876
Atrial flutter 44.14 29.09 21 13902 1196 2342966
Otitis media acute 44.08 29.09 12 13911 127 2344035
Denture wearer 43.96 29.09 10 13913 46 2344116
Large intestine benign neoplasm 43.92 29.09 9 13914 22 2344140
Localised infection 43.85 29.09 28 13895 2848 2341314
Papilloma 43.78 29.09 10 13913 47 2344115
Electrocardiogram ST segment abnormal 43.73 29.09 13 13910 193 2343969
Malabsorption 43.68 29.09 17 13906 589 2343573
Incision site cellulitis 43.63 29.09 9 13914 23 2344139
Thrombophlebitis superficial 43.51 29.09 18 13905 733 2343429
Myelopathy 43.46 29.09 15 13908 367 2343795
Muscle tightness 43.31 29.09 24 13899 1881 2342281
Blood creatinine increased 43.30 29.09 48 13875 10485 2333677
Phlebitis superficial 43.05 29.09 11 13912 89 2344073
Food allergy 43.01 29.09 17 13906 614 2343548
Odontogenic cyst 42.89 29.09 8 13915 9 2344153
Adjustment disorder with depressed mood 42.73 29.09 11 13912 92 2344070
Bone operation 42.63 29.09 11 13912 93 2344069
Productive cough 42.49 29.09 35 13888 5286 2338876
Carotid endarterectomy 42.33 29.09 9 13914 28 2344134
Drug interaction 42.26 29.09 81 13842 29082 2315080
Hallucination 42.19 29.09 42 13881 8106 2336056
Calcinosis 42.18 29.09 14 13909 303 2343859
Bone fistula 42.17 29.09 10 13913 57 2344105
Metaplasia 42.11 29.09 11 13912 98 2344064
Tendon sheath incision 42.09 29.09 9 13914 29 2344133
Post procedural hypothyroidism 42.09 29.09 9 13914 29 2344133
Cardiomyopathy 41.98 29.09 27 13896 2780 2341382
Coronary artery stenosis 41.96 29.09 18 13905 803 2343359
Hyperparathyroidism secondary 41.76 29.09 12 13911 157 2344005
Wisdom teeth removal 41.72 29.09 11 13912 102 2344060
Polyuria 41.66 29.09 20 13903 1162 2343000
Proteinuria 41.61 29.09 27 13896 2823 2341339
Skin irritation 41.56 29.09 21 13902 1364 2342798
Conjunctivitis allergic 41.49 29.09 12 13911 161 2344001
Sensation of foreign body 41.48 29.09 18 13905 826 2343336
Vascular insufficiency 41.46 29.09 10 13913 62 2344100
Bone abscess 41.32 29.09 10 13913 63 2344099
Acne 41.31 29.09 28 13895 3148 2341014
Helicobacter gastritis 41.25 29.09 13 13910 237 2343925
Female sterilisation 41.25 29.09 11 13912 107 2344055
Faeces discoloured 41.10 29.09 25 13898 2334 2341828
Gingivectomy 41.04 29.09 7 13916 2 2344160
Benign breast lump removal 41.04 29.09 7 13916 2 2344160
Accident 40.99 29.09 18 13905 850 2343312
Oesophageal adenocarcinoma 40.98 29.09 9 13914 34 2344128
Gastric pH decreased 40.92 29.09 10 13913 66 2344096
Polycythaemia vera 40.92 29.09 10 13913 66 2344096
Thalassaemia beta 40.83 29.09 8 13915 14 2344148
Lymphadenitis 40.80 29.09 15 13908 443 2343719
Tongue geographic 40.78 29.09 9 13914 35 2344127
Hyperplasia 40.76 29.09 12 13911 172 2343990
Bladder cancer 40.75 29.09 17 13906 707 2343455
Urine odour abnormal 40.71 29.09 17 13906 709 2343453
Breast cancer metastatic 40.67 29.09 24 13899 2120 2342042
Soft tissue infection 40.62 29.09 14 13909 341 2343821
Oral mucosal erythema 40.60 29.09 13 13910 250 2343912
Gastric haemorrhage 40.40 29.09 19 13904 1054 2343108
Vaginal haemorrhage 40.28 29.09 33 13890 4947 2339215
Viral upper respiratory tract infection 40.20 29.09 19 13904 1066 2343096
Cubital tunnel syndrome 40.19 29.09 9 13914 38 2344124
Bronchospasm 40.15 29.09 27 13896 2997 2341165
Dystrophic calcification 40.14 29.09 8 13915 16 2344146
Fractured ischium 40.14 29.09 8 13915 16 2344146
Chest injury 40.01 29.09 12 13911 184 2343978
Ovarian cystectomy 40.00 29.09 9 13914 39 2344123
Visual field defect 39.76 29.09 21 13902 1495 2342667
Deformity 39.61 29.09 15 13908 482 2343680
Tooth repair 39.58 29.09 10 13913 77 2344085
Ageusia 39.57 29.09 23 13900 1975 2342187
Pelvic floor muscle weakness 39.50 29.09 8 13915 18 2344144
Allergy to vaccine 39.50 29.09 8 13915 18 2344144
Mitral valve calcification 39.46 29.09 11 13912 128 2344034
Blood parathyroid hormone increased 39.42 29.09 16 13907 620 2343542
Leukopenia 39.41 29.09 45 13878 10151 2334011
Movement disorder 39.35 29.09 26 13897 2802 2341360
Oesophageal rupture 39.24 29.09 10 13913 80 2344082
Tooth erosion 39.00 29.09 11 13912 134 2344028
Dacryostenosis acquired 38.93 29.09 11 13912 135 2344027
Tendon injury 38.92 29.09 13 13910 287 2343875
Toe operation 38.71 29.09 11 13912 138 2344024
Obsessive-compulsive disorder 38.66 29.09 16 13907 652 2343510
Bone atrophy 38.63 29.09 8 13915 21 2344141
Measles 38.62 29.09 9 13914 47 2344115
Fungal skin infection 38.56 29.09 15 13908 519 2343643
Pulmonary valve incompetence 38.53 29.09 12 13911 210 2343952
Fracture reduction 38.47 29.09 7 13916 6 2344156
Pelvic adhesions 38.46 29.09 9 13914 48 2344114
Lentigo 38.39 29.09 10 13913 88 2344074
Colectomy 38.21 29.09 15 13908 532 2343630
Lactose intolerance 38.10 29.09 13 13910 307 2343855
Joint dislocation reduction 37.96 29.09 7 13916 7 2344155
Dysplasia 37.80 29.09 11 13912 151 2344011
Catheterisation cardiac 37.74 29.09 16 13907 693 2343469
Aortic dilatation 37.71 29.09 10 13913 95 2344067
Eye operation 37.71 29.09 13 13910 317 2343845
Lung neoplasm malignant 37.63 29.09 26 13897 3016 2341146
Urinary hesitation 37.61 29.09 12 13911 228 2343934
Thirst 37.58 29.09 21 13902 1673 2342489
X-ray of pelvis and hip abnormal 37.47 29.09 7 13916 8 2344154
Traumatic arthritis 37.47 29.09 7 13916 8 2344154
Mucous stools 37.18 29.09 13 13910 331 2343831
Cerebral infarction 37.14 29.09 30 13893 4407 2339755
Benign bone neoplasm 37.13 29.09 8 13915 27 2344135
Infective exacerbation of chronic obstructive airways disease 37.02 29.09 11 13912 163 2343999
Excessive granulation tissue 37.02 29.09 11 13912 163 2343999
Mucosal ulceration 36.94 29.09 12 13911 242 2343920
Enterococcal infection 36.85 29.09 16 13907 735 2343427
Abnormal faeces 36.74 29.09 15 13908 590 2343572
Biliary dilatation 36.74 29.09 13 13910 343 2343819
Invasive ductal breast carcinoma 36.73 29.09 17 13906 909 2343253
Breast cancer recurrent 36.69 29.09 16 13907 743 2343419
Oophorectomy bilateral 36.69 29.09 8 13915 29 2344133
Fibrous dysplasia of bone 36.60 29.09 7 13916 10 2344152
Dysplastic naevus syndrome 36.60 29.09 7 13916 10 2344152
Exposure during pregnancy 36.48 29.09 70 13853 25149 2319013
Umbilical hernia repair 36.48 29.09 8 13915 30 2344132
Cardiac failure 36.36 29.09 47 13876 12047 2332115
Hypovitaminosis 36.30 29.09 10 13913 111 2344051
Corneal abrasion 36.30 29.09 11 13912 175 2343987
Claustrophobia 36.14 29.09 10 13913 113 2344049
Elbow operation 36.12 29.09 9 13914 65 2344097
Incision site erythema 36.12 29.09 9 13914 65 2344097
Electrocardiogram T wave abnormal 36.11 29.09 13 13910 361 2343801
Cushing's syndrome 36.09 29.09 16 13907 773 2343389
Breast cancer in situ 36.08 29.09 13 13910 362 2343800
Piriformis syndrome 36.07 29.09 8 13915 32 2344130
Angina unstable 36.05 29.09 19 13904 1347 2342815
Soft tissue inflammation 36.00 29.09 9 13914 66 2344096
Adrenal adenoma 35.90 29.09 10 13913 116 2344046
Attention deficit/hyperactivity disorder 35.85 29.09 13 13910 369 2343793
Vascular headache 35.82 29.09 7 13916 12 2344150
White blood cell count increased 35.75 29.09 36 13887 7042 2337120
Meningioma 35.70 29.09 15 13908 635 2343527
Rubber sensitivity 35.61 29.09 13 13910 376 2343786
Ventricular tachycardia 35.53 29.09 25 13898 2986 2341176
Colitis ischaemic 35.52 29.09 20 13903 1617 2342545
Surgical failure 35.44 29.09 10 13913 122 2344040
Breast reconstruction 35.43 29.09 9 13914 71 2344091
Anaemia vitamin B12 deficiency 35.31 29.09 9 13914 72 2344090
Vertebrobasilar insufficiency 35.31 29.09 8 13915 36 2344126
Salivary gland mass 35.13 29.09 8 13915 37 2344125
Lower gastrointestinal haemorrhage 35.10 29.09 17 13906 1007 2343155
Vulvovaginal pruritus 34.97 29.09 14 13909 523 2343639
Lip swelling 34.97 29.09 30 13893 4791 2339371
Gastric cancer 34.95 29.09 15 13908 670 2343492
Ataxia 34.89 29.09 23 13900 2469 2341693
Paranasal sinus hypersecretion 34.80 29.09 15 13908 677 2343485
Abdominal adhesions 34.80 29.09 14 13909 530 2343632
Psoriasis 34.77 29.09 55 13868 16953 2327209
Gastric perforation 34.67 29.09 12 13911 296 2343866
Vulvovaginal mycotic infection 34.63 29.09 16 13907 852 2343310
Neurogenic bladder 34.55 29.09 13 13910 410 2343752
Lethargy 34.54 29.09 39 13884 8691 2335471
Jaw fistula 34.49 29.09 7 13916 16 2344146
Mastoid disorder 34.49 29.09 7 13916 16 2344146
Traumatic haematoma 34.43 29.09 11 13912 210 2343952
Rectal prolapse 34.38 29.09 11 13912 211 2343951
Myelodysplastic syndrome 34.33 29.09 23 13900 2537 2341625
Alcohol abuse 34.15 29.09 12 13911 310 2343852
Blood pressure inadequately controlled 34.08 29.09 16 13907 884 2343278
Uterine cervix stenosis 33.98 29.09 8 13915 44 2344118
Vasculitis 33.93 29.09 22 13901 2296 2341866
Arrhythmia supraventricular 33.72 29.09 11 13912 225 2343937
Spider vein 33.71 29.09 9 13914 88 2344074
Tobacco abuse 33.71 29.09 9 13914 88 2344074
Oesophageal irritation 33.68 29.09 8 13915 46 2344116
Device loosening 33.68 29.09 8 13915 46 2344116
Uterovaginal prolapse 33.63 29.09 7 13916 19 2344143
Deafness unilateral 33.47 29.09 14 13909 586 2343576
Tongue discolouration 33.43 29.09 14 13909 588 2343574
Vascular operation 33.25 29.09 8 13915 49 2344113
Foreign body aspiration 33.17 29.09 9 13914 94 2344068
Oesophageal obstruction 33.08 29.09 9 13914 95 2344067
Tendon sheath lesion excision 33.05 29.09 6 13917 5 2344157
Malignant hypertension 32.97 29.09 11 13912 242 2343920
Allergic sinusitis 32.91 29.09 9 13914 97 2344065
Bacterial disease carrier 32.91 29.09 9 13914 97 2344065
Hypoalbuminaemia 32.89 29.09 18 13905 1376 2342786
Cataract cortical 32.87 29.09 7 13916 22 2344140
Deafness bilateral 32.84 29.09 11 13912 245 2343917
Procedural vomiting 32.83 29.09 9 13914 98 2344064
Adrenal insufficiency 32.82 29.09 18 13905 1382 2342780
Skin graft 32.77 29.09 10 13913 163 2343999
Atrial tachycardia 32.75 29.09 12 13911 351 2343811
Haemorrhagic disorder 32.66 29.09 10 13913 165 2343997
Nephrosclerosis 32.55 29.09 10 13913 167 2343995
Sinus tarsi syndrome 32.53 29.09 6 13917 6 2344156
Radiotherapy to breast 32.53 29.09 6 13917 6 2344156
Medication error 32.48 29.09 32 13891 6099 2338063
Synovectomy 32.45 29.09 8 13915 55 2344107
Colitis ulcerative 32.45 29.09 23 13900 2779 2341383
Gastric infection 32.34 29.09 12 13911 364 2343798
Type 1 diabetes mellitus 32.27 29.09 14 13909 642 2343520
Panic disorder 32.19 29.09 13 13910 497 2343665
Hair follicle tumour benign 32.18 29.09 7 13916 25 2344137
Cachexia 32.17 29.09 15 13908 816 2343346
Skin exfoliation 32.13 29.09 31 13892 5759 2338403
Cognitive disorder 32.12 29.09 30 13893 5351 2338811
Vocal cord neoplasm 32.05 29.09 6 13917 7 2344155
Lip neoplasm 32.05 29.09 6 13917 7 2344155
Sepsis syndrome 31.96 29.09 9 13914 109 2344053
Kidney infection 31.88 29.09 22 13901 2547 2341615
Tinea pedis 31.85 29.09 10 13913 180 2343982
Bone density increased 31.84 29.09 8 13915 60 2344102
Affective disorder 31.81 29.09 15 13908 837 2343325
Bursa disorder 31.73 29.09 8 13915 61 2344101
Open angle glaucoma 31.66 29.09 9 13914 113 2344049
Suicidal ideation 31.64 29.09 42 13881 11045 2333117
Cancer surgery 31.59 29.09 9 13914 114 2344048
Chest wall mass 31.56 29.09 7 13916 28 2344134
Polyneuropathy 31.53 29.09 19 13904 1744 2342418
Live birth 31.38 29.09 17 13906 1274 2342888
Abdominal hernia repair 31.36 29.09 7 13916 29 2344133
Pleural fibrosis 31.29 29.09 10 13913 191 2343971
Hypophagia 31.29 29.09 26 13897 3974 2340188
Eosinophilia 31.24 29.09 23 13900 2947 2341215
Choking 31.24 29.09 18 13905 1520 2342642
Skin neoplasm excision 31.23 29.09 9 13914 119 2344043
Duodenal ulcer haemorrhage 31.21 29.09 12 13911 402 2343760
Actinic elastosis 31.20 29.09 6 13917 9 2344153
Intestinal obstruction 31.18 29.09 27 13896 4366 2339796
Lyme disease 31.16 29.09 12 13911 404 2343758
Chronic lymphocytic leukaemia 31.13 29.09 13 13910 542 2343620
Neoplasm skin 31.05 29.09 10 13913 196 2343966
Oesophagitis ulcerative 31.03 29.09 9 13914 122 2344040
Blood 25-hydroxycholecalciferol decreased 30.98 29.09 7 13916 31 2344131
Pelvic mass 30.91 29.09 10 13913 199 2343963
Basedow's disease 30.86 29.09 13 13910 554 2343608
Nasal septal operation 30.80 29.09 7 13916 32 2344130
Nasal turbinate hypertrophy 30.80 29.09 7 13916 32 2344130
Retching 30.79 29.09 20 13903 2094 2342068
Corneal dystrophy 30.76 29.09 8 13915 70 2344092
Walking aid user 30.61 29.09 14 13909 728 2343434
Thrombocytosis 30.60 29.09 15 13908 912 2343250
Postoperative heterotopic calcification 30.57 29.09 5 13918 0 2344162
Lip injury 30.50 29.09 9 13914 130 2344032
Joint ankylosis 30.46 29.09 8 13915 73 2344089
Monoclonal gammopathy 30.44 29.09 9 13914 131 2344031
Blood thyroid stimulating hormone decreased 30.43 29.09 13 13910 574 2343588
Thyroid mass 30.42 29.09 12 13911 431 2343731
Swollen tongue 30.39 29.09 29 13894 5314 2338848
Failure to thrive 30.38 29.09 15 13908 927 2343235
Blood sodium decreased 30.36 29.09 23 13900 3077 2341085
Seborrhoeic dermatitis 30.31 29.09 9 13914 133 2344029
Alpha haemolytic streptococcal infection 30.31 29.09 9 13914 133 2344029
Influenza like illness 30.22 29.09 43 13880 12071 2332091
Somatic symptom disorder 30.21 29.09 11 13912 316 2343846
Chorioretinitis 30.17 29.09 8 13915 76 2344086
Folliculitis 30.13 29.09 13 13910 588 2343574
Aortic valve replacement 30.13 29.09 9 13914 136 2344026
Fat necrosis 30.13 29.09 9 13914 136 2344026
Pneumonia bacterial 29.93 29.09 15 13908 957 2343205
Plasma cell myeloma 29.93 29.09 35 13888 8098 2336064
Abscess drainage 29.88 29.09 9 13914 140 2344022
Adrenal mass 29.83 29.09 9 13914 141 2344021
Thrombophlebitis 29.79 29.09 14 13909 775 2343387
Breast cyst excision 29.78 29.09 6 13917 13 2344149
Incision site haemorrhage 29.77 29.09 9 13914 142 2344020
Ischaemia 29.74 29.09 14 13909 778 2343384
Dilatation atrial 29.60 29.09 11 13912 335 2343827
Blood pressure decreased 29.51 29.09 37 13886 9199 2334963
Ligament injury 29.42 29.09 9 13914 148 2344014
Cerebral arteriosclerosis 29.36 29.09 8 13915 85 2344077
Autoimmune disorder 29.33 29.09 14 13909 803 2343359
Tendon operation 29.28 29.09 8 13915 86 2344076
Left ventricular dysfunction 29.23 29.09 16 13907 1224 2342938
Osteochondroma 29.18 29.09 6 13917 15 2344147
Splenic granuloma 29.18 29.09 6 13917 15 2344147
Lip neoplasm malignant stage unspecified 29.18 29.09 6 13917 15 2344147
Suture related complication 29.11 29.09 8 13915 88 2344074

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis 1016.25 33.78 207 1368 3755 1741451
Osteonecrosis of jaw 684.07 33.78 152 1423 4151 1741055
Femur fracture 648.95 33.78 117 1458 1030 1744176
Osteomyelitis 395.78 33.78 87 1488 2208 1742998
Impaired healing 358.54 33.78 82 1493 2497 1742709
Dental caries 323.60 33.78 60 1515 613 1744593
Osteoarthritis 271.08 33.78 64 1511 2232 1742974
Low turnover osteopathy 267.51 33.78 35 1540 6 1745200
Gastrooesophageal reflux disease 244.61 33.78 68 1507 4579 1740627
Fall 241.85 33.78 105 1470 27109 1718097
Tooth disorder 222.59 33.78 50 1525 1387 1743819
Tooth loss 202.50 33.78 40 1535 581 1744625
Tooth fracture 187.37 33.78 36 1539 448 1744758
Stress fracture 179.27 33.78 30 1545 156 1745050
Anxiety 177.90 33.78 72 1503 15455 1729751
Atypical femur fracture 174.88 33.78 26 1549 50 1745156
Osteoporosis 171.09 33.78 41 1534 1514 1743692
Arthralgia 164.80 33.78 77 1498 23367 1721839
Exostosis 163.69 33.78 32 1543 438 1744768
Depression 162.85 33.78 69 1506 16600 1728606
Arthropathy 160.02 33.78 44 1531 2823 1742383
Intramedullary rod insertion 153.13 33.78 20 1555 3 1745203
Osteopenia 152.67 33.78 31 1544 520 1744686
Back pain 149.80 33.78 65 1510 16548 1728658
Rectal haemorrhage 143.46 33.78 47 1528 5495 1739711
Periodontal disease 136.69 33.78 23 1552 124 1745082
Spinal osteoarthritis 136.17 33.78 30 1545 755 1744451
Benign prostatic hyperplasia 133.99 33.78 33 1542 1365 1743841
Hypertension 133.75 33.78 63 1512 19385 1725821
Hiatus hernia 133.49 33.78 31 1544 994 1744212
Jaw disorder 133.32 33.78 27 1548 446 1744760
Hyperlipidaemia 132.65 33.78 36 1539 2193 1743013
Chronic obstructive pulmonary disease 132.25 33.78 45 1530 5908 1739298
Bone density decreased 125.10 33.78 24 1551 295 1744911
Temporomandibular joint syndrome 124.21 33.78 21 1554 117 1745089
Tooth abscess 122.86 33.78 28 1547 824 1744382
Open reduction of fracture 122.31 33.78 17 1558 14 1745192
Upper gastrointestinal haemorrhage 122.09 33.78 36 1539 2963 1742243
Pain in jaw 121.65 33.78 33 1542 2005 1743201
Oral infection 117.75 33.78 22 1553 232 1744974
Pneumonia 115.90 33.78 77 1498 46105 1699101
Jaw fracture 106.85 33.78 20 1555 213 1744993
Sleep apnoea syndrome 106.09 33.78 30 1545 2124 1743082
Exostosis of jaw 104.22 33.78 15 1560 20 1745186
Rib fracture 102.62 33.78 28 1547 1736 1743470
Periodontitis 101.61 33.78 20 1555 283 1744923
Pain 101.25 33.78 58 1517 26599 1718607
Spinal compression fracture 100.94 33.78 24 1551 852 1744354
Fracture nonunion 100.12 33.78 15 1560 31 1745175
Cellulitis 98.57 33.78 37 1538 6431 1738775
Oesophageal ulcer 97.48 33.78 22 1553 618 1744588
Intervertebral disc degeneration 97.44 33.78 22 1553 619 1744587
Foot fracture 96.05 33.78 22 1553 661 1744545
Tibia fracture 95.99 33.78 19 1556 277 1744929
Gastritis 95.15 33.78 30 1545 3087 1742119
Bone disorder 94.79 33.78 25 1550 1360 1743846
Anaemia 93.28 33.78 57 1518 29400 1715806
Anaemia postoperative 92.63 33.78 16 1559 103 1745103
Gastric ulcer 91.00 33.78 28 1547 2657 1742549
Adverse drug reaction 90.39 33.78 32 1543 4706 1740500
Pathological fracture 88.46 33.78 20 1555 566 1744640
Atrial fibrillation 85.73 33.78 43 1532 15068 1730138
Oesophagitis 85.13 33.78 24 1551 1677 1743529
Scoliosis 84.75 33.78 17 1558 266 1744940
Resorption bone increased 84.62 33.78 13 1562 34 1745172
Adverse event 83.26 33.78 30 1545 4638 1740568
Spinal fracture 83.07 33.78 21 1554 964 1744242
Drug hypersensitivity 82.73 33.78 42 1533 15093 1730113
Abscess 82.09 33.78 24 1551 1910 1743296
Haematemesis 81.34 33.78 29 1546 4348 1740858
Gingival disorder 80.78 33.78 16 1559 234 1744972
Pain in extremity 80.36 33.78 44 1531 18428 1726778
Blood cholesterol increased 79.53 33.78 26 1549 3000 1742206
Oesophageal carcinoma 79.43 33.78 19 1556 691 1744515
Gastrointestinal haemorrhage 79.15 33.78 40 1535 14227 1730979
Compression fracture 78.18 33.78 17 1558 400 1744806
Diverticulitis 77.73 33.78 24 1551 2301 1742905
Erectile dysfunction 76.83 33.78 28 1547 4469 1740737
Gingivitis 76.33 33.78 18 1557 615 1744591
Lumbar spinal stenosis 76.11 33.78 16 1559 319 1744887
Hip fracture 75.76 33.78 22 1553 1708 1743498
Cataract 75.72 33.78 25 1550 2973 1742233
Oral pain 75.30 33.78 21 1554 1409 1743797
Oral disorder 74.97 33.78 18 1557 665 1744541
Intervertebral disc protrusion 74.13 33.78 21 1554 1492 1743714
Tooth extraction 73.70 33.78 20 1555 1212 1743994
Deafness 72.99 33.78 22 1553 1944 1743262
Weight decreased 71.82 33.78 44 1531 22709 1722497
Asthenia 70.62 33.78 51 1524 34619 1710587
Bursitis 70.26 33.78 17 1558 649 1744557
Myalgia 70.00 33.78 38 1537 15620 1729586
Internal fixation of fracture 70.00 33.78 11 1564 35 1745171
Hypercalciuria 69.63 33.78 12 1563 76 1745130
Hypophosphataemic osteomalacia 69.53 33.78 11 1564 37 1745169
Chest pain 69.27 33.78 41 1534 19873 1725333
Arthritis 68.82 33.78 25 1550 3950 1741256
Coronary artery disease 67.74 33.78 32 1543 9814 1735392
Fibula fracture 67.19 33.78 13 1562 167 1745039
Laryngeal ulceration 66.62 33.78 10 1565 21 1745185
Abdominal pain 66.38 33.78 41 1534 21449 1723757
Urinary retention 64.85 33.78 26 1549 5369 1739837
Hypercholesterolaemia 64.73 33.78 18 1557 1194 1744012
Vitamin D deficiency 64.34 33.78 15 1560 487 1744719
Dysphagia 63.73 33.78 31 1544 10137 1735069
Fracture 62.14 33.78 17 1558 1061 1744145
Rheumatoid arthritis 61.77 33.78 24 1551 4561 1740645
Haemorrhoids 61.71 33.78 19 1556 1802 1743404
Bronchitis 61.23 33.78 25 1550 5407 1739799
Iron deficiency anaemia 60.65 33.78 17 1558 1161 1744045
Medical device removal 60.02 33.78 10 1565 50 1745156
Exposed bone in jaw 59.36 33.78 14 1561 478 1744728
Oedema peripheral 59.28 33.78 34 1541 15516 1729690
Constipation 57.71 33.78 33 1542 14967 1730239
Nephrolithiasis 57.71 33.78 22 1553 3970 1741236
Rhinitis allergic 57.60 33.78 13 1562 364 1744842
Inguinal hernia 57.53 33.78 16 1559 1061 1744145
Trismus 57.49 33.78 14 1561 549 1744657
Gait disturbance 57.28 33.78 31 1544 12639 1732567
Muscle spasms 56.94 33.78 30 1545 11591 1733615
Joint dislocation 56.60 33.78 14 1561 586 1744620
Abscess jaw 56.23 33.78 11 1564 150 1745056
Atypical fracture 55.42 33.78 8 1567 11 1745195
Insomnia 55.21 33.78 33 1542 16243 1728963
Dental fistula 54.71 33.78 9 1566 41 1745165
Large intestine polyp 54.56 33.78 15 1560 953 1744253
Duodenal ulcer perforation 54.55 33.78 12 1563 298 1744908
Peptic ulcer 53.67 33.78 13 1562 498 1744708
Asthma 53.32 33.78 22 1553 4882 1740324
Device failure 53.08 33.78 14 1561 759 1744447
Craniotabes 52.79 33.78 7 1568 2 1745204
Bone loss 52.46 33.78 10 1565 118 1745088
Tooth infection 52.45 33.78 14 1561 795 1744411
Neuropathy peripheral 51.40 33.78 26 1549 9227 1735979
Dizziness 51.15 33.78 42 1533 34319 1710887
Ankle fracture 50.64 33.78 13 1562 633 1744573
Gingival bleeding 50.23 33.78 15 1560 1281 1743925
Toothache 49.61 33.78 14 1561 979 1744227
Chronic kidney disease 49.08 33.78 20 1555 4297 1740909
Oesophageal stenosis 48.30 33.78 11 1564 321 1744885
Bone pain 46.69 33.78 18 1557 3344 1741862
Kyphosis 46.26 33.78 9 1566 119 1745087
Spinal stenosis 45.55 33.78 12 1563 647 1744559
Gingival pain 45.52 33.78 11 1564 417 1744789
Melaena 45.46 33.78 20 1555 5190 1740016
Anaemia of chronic disease 45.02 33.78 9 1566 138 1745068
Cardiac failure congestive 44.21 33.78 28 1547 15242 1729964
Carpal tunnel syndrome 44.13 33.78 12 1563 731 1744475
Epiglottis ulcer 43.12 33.78 6 1569 5 1745201
Calcium deficiency 42.90 33.78 7 1568 30 1745176
Lumbar vertebral fracture 42.72 33.78 10 1565 330 1744876
Foreign body 42.32 33.78 10 1565 344 1744862
Bone metabolism disorder 42.01 33.78 7 1568 35 1745171
Meniscus injury 41.38 33.78 10 1565 379 1744827
Loose tooth 41.28 33.78 9 1566 214 1744992
Diverticulum 40.53 33.78 12 1563 994 1744212
Tendonitis 40.40 33.78 13 1562 1420 1743786
Acetabulum fracture 40.38 33.78 7 1568 46 1745160
Renal cyst 40.14 33.78 12 1563 1028 1744178
Dyspnoea 39.76 33.78 44 1531 52015 1693191
Radiculopathy 39.74 33.78 10 1565 449 1744757
Joint injury 39.57 33.78 12 1563 1079 1744127
Circulatory collapse 39.19 33.78 16 1559 3451 1741755
Sinusitis 39.04 33.78 18 1557 5205 1740001
Chemical burn of respiratory tract 38.96 33.78 5 1570 0 1745206
Erosive oesophagitis 38.86 33.78 9 1566 283 1744923
Nocturia 38.83 33.78 12 1563 1149 1744057
Contusion 38.76 33.78 18 1557 5291 1739915
Cough 38.39 33.78 28 1547 19169 1726037
Sequestrectomy 38.35 33.78 8 1567 153 1745053
Herpes zoster 38.10 33.78 17 1558 4556 1740650
Cerebrovascular accident 37.88 33.78 27 1548 17839 1727367
Barrett's oesophagus 37.74 33.78 9 1566 322 1744884
Irritable bowel syndrome 37.71 33.78 10 1565 553 1744653
Osteitis 37.24 33.78 9 1566 341 1744865
Rotator cuff syndrome 37.12 33.78 11 1564 914 1744292
Basal cell carcinoma 37.00 33.78 14 1561 2469 1742737
Oral cavity fistula 36.76 33.78 7 1568 82 1745124
Dyspepsia 36.69 33.78 17 1558 4968 1740238
Infection 36.60 33.78 23 1552 12337 1732869
Osteoradionecrosis 36.17 33.78 6 1569 29 1745177
Fracture delayed union 36.17 33.78 6 1569 29 1745177
Musculoskeletal discomfort 36.17 33.78 11 1564 998 1744208
Deep vein thrombosis 35.91 33.78 21 1554 9899 1735307
Choking 35.89 33.78 11 1564 1025 1744181
Epiglottitis 35.47 33.78 7 1568 100 1745106
Lung neoplasm 35.04 33.78 10 1565 727 1744479
Gastric haemorrhage 34.53 33.78 14 1561 2964 1742242
Groin pain 34.52 33.78 10 1565 767 1744439
Diabetes mellitus 34.26 33.78 18 1557 6890 1738316
Lower limb fracture 34.21 33.78 10 1565 792 1744414
Emphysema 33.84 33.78 11 1564 1240 1743966
Femoral neck fracture 33.84 33.78 9 1566 503 1744703
Fatigue 33.81 33.78 40 1535 50741 1694465
Helicobacter test positive 33.80 33.78 7 1568 129 1745077

Pharmacologic Action:

SourceCodeDescription
ATC M05BA04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates
ATC M05BB03 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB05 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB06 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
FDA EPC N0000175579 Bisphosphonate
FDA Chemical/Ingredient N0000007707 Diphosphonates
CHEBI has role CHEBI:50646 bone density conservation agent
MeSH PA D050071 Bone Density Conservation Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Osteitis deformans indication 2089002 DOID:5408
Postmenopausal osteoporosis indication 102447009
Prevention of Glucocorticoid-Induced Osteoporosis indication
Glucocorticoid Induced Osteoporosis indication
Hypogonadal Osteoporosis in Males indication
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Esophagitis contraindication 16761005 DOID:11963
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Ulcer of esophagus contraindication 30811009
Sarcoidosis contraindication 31541009 DOID:11335
Vitamin D deficiency contraindication 34713006
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Atrial fibrillation contraindication 49436004 DOID:0060224
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Stricture of esophagus contraindication 63305008
Hypercalcemia contraindication 66931009 DOID:12678
Fracture of femur contraindication 71620000
Duodenitis contraindication 72007001 DOID:8643
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Bed-ridden contraindication 160685001
Acute peptic ulcer contraindication 196682000
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Aseptic necrosis of bone of jaw contraindication 441809006
Esophageal Obstruction contraindication
High Grade Dysplasia associated with Barrett's Esophagus contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.27 acidic
pKa2 5.34 acidic
pKa3 6.32 acidic
pKa4 10.39 acidic
pKa5 12.82 acidic
pKa6 10.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Farnesyl pyrophosphate synthase Enzyme INHIBITOR Ki 7.35 CHEMBL CHEMBL
Protein farnesyltransferase subunit beta Enzyme IC50 7.30 WOMBAT-PK
Farnesyl pyrophosphate synthase Enzyme Ki 7.02 CHEMBL

External reference:

IDSource
4020932 VUID
N0000148414 NUI
C0102118 UMLSCUI
D00939 KEGG_DRUG
2UY4M2U3RA UNII
121268-17-5 SECONDARY_CAS_RN
421552005 SNOMEDCT_US
236083 RXNORM
391730008 SNOMEDCT_US
005056 NDDF
CHEBI:2567 CHEBI
CHEMBL675 ChEMBL_ID
CHEMBL870 ChEMBL_ID
DB00630 DRUGBANK_ID
212 PDB_CHEM_ID
AHD PDB_CHEM_ID
6462 INN_ID
3141 IUPHAR_LIGAND_ID
2088 PUBCHEM_CID
D019386 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FOSAMAX HUMAN PRESCRIPTION DRUG LABEL 1 0006-0031 TABLET 70 mg ORAL NDA 18 sections
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0270 TABLET 70 mg ORAL NDA 18 sections
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0710 TABLET 70 mg ORAL NDA 18 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1676 TABLET 5 mg ORAL ANDA 19 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1678 TABLET 10 mg ORAL ANDA 19 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1679 TABLET 35 mg ORAL ANDA 19 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1680 TABLET 40 mg ORAL ANDA 19 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1681 TABLET 70 mg ORAL ANDA 19 sections
Binosto HUMAN PRESCRIPTION DRUG LABEL 1 0178-0101 TABLET, EFFERVESCENT 70 mg ORAL NDA 17 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-696 TABLET 35 mg ORAL ANDA 17 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 10135-697 TABLET 70 mg ORAL ANDA 17 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16714-631 TABLET 10 mg ORAL ANDA 17 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16714-632 TABLET 35 mg ORAL ANDA 17 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16714-633 TABLET 70 mg ORAL ANDA 17 sections
Binosto HUMAN PRESCRIPTION DRUG LABEL 1 17139-400 TABLET, EFFERVESCENT 70 mg ORAL NDA 17 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-901 TABLET 35 mg ORAL ANDA 13 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-902 TABLET 70 mg ORAL ANDA 13 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-554 TABLET 70 mg ORAL ANDA 17 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-820 TABLET 70 mg ORAL ANDA 17 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-993 TABLET 35 mg ORAL ANDA 18 sections
alendronate sodium HUMAN PRESCRIPTION DRUG LABEL 1 50090-1091 TABLET 35 mg ORAL ANDA 18 sections
alendronate sodium HUMAN PRESCRIPTION DRUG LABEL 1 50090-1095 TABLET 70 mg ORAL ANDA 18 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 50090-2322 TABLET 70 mg ORAL ANDA 17 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 50090-3126 TABLET 70 mg ORAL ANDA 18 sections
Alendronate HUMAN PRESCRIPTION DRUG LABEL 1 50090-3593 TABLET 35 mg ORAL ANDA 19 sections
ALENDRONATE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 50090-4076 TABLET 35 mg ORAL ANDA 18 sections
ALENDRONATE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 50090-4692 TABLET 70 mg ORAL ANDA 17 sections
Alendronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 51224-301 SOLUTION 70 mg ORAL ANDA 17 sections
alendronate sodium HUMAN PRESCRIPTION DRUG LABEL 1 53217-321 TABLET 35 mg ORAL ANDA 18 sections
Fosamax HUMAN PRESCRIPTION DRUG LABEL 1 54868-3857 TABLET, COATED 10 mg ORAL NDA 14 sections