calcitriol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 466 32222-06-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • rocaltrol
  • calcitriol
  • Dihydroxyvitamin D3
  • topitriol
  • 1,25-dihydroxyvitamin D3
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
  • Molecular weight: 416.65
  • Formula: C27H44O3
  • CLOGP: 6.04
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 3
  • TPSA: 60.69
  • ALOGS: -4.80
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 mcg O
1 mcg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.00 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 61 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.25 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.31 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 11 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 17, 1978 FDA VALIDUS PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Recalled product 1068.23 11.15 216 25545 1187 63462074
Hypocalcaemia 581.27 11.15 275 25486 31438 63431823
Hypercalcaemia 492.75 11.15 237 25524 28085 63435176
Milk-alkali syndrome 251.51 11.15 60 25701 768 63462493
Calciphylaxis 209.29 11.15 69 25692 3003 63460258
Peritonitis bacterial 188.82 11.15 72 25689 4807 63458454
Blood calcium decreased 156.92 11.15 110 25651 26341 63436920
Tetany 140.55 11.15 46 25715 1955 63461306
Blood parathyroid hormone increased 129.05 11.15 48 25713 2990 63460271
Shunt stenosis 127.72 11.15 32 25729 508 63462753
Arteriovenous fistula site complication 114.39 11.15 29 25732 484 63462777
Blood calcium abnormal 109.03 11.15 34 25727 1234 63462027
Nephrocalcinosis 97.30 11.15 30 25731 1048 63462213
Nephrogenic systemic fibrosis 94.19 11.15 43 25718 4513 63458748
Shunt occlusion 93.05 11.15 26 25735 639 63462622
Peritonitis 89.49 11.15 66 25695 17088 63446173
Hypercalciuria 80.76 11.15 20 25741 302 63462959
Renal failure 80.28 11.15 159 25602 117493 63345768
Hypoparathyroidism 79.09 11.15 23 25738 655 63462606
Chronic kidney disease 74.49 11.15 92 25669 45306 63417955
Aplasia pure red cell 70.31 11.15 35 25726 4452 63458809
Blood calcium increased 70.13 11.15 45 25716 9305 63453956
Acute kidney injury 67.17 11.15 247 25514 263168 63200093
Rheumatoid arthritis 63.24 11.15 13 25748 253806 63209455
Renal impairment 62.18 11.15 121 25640 88234 63375027
Drug ineffective 61.10 11.15 219 25542 1044546 62418715
Drug intolerance 57 11.15 27 25734 308634 63154627
Treatment failure 54.37 11.15 8 25753 199035 63264226
Glossodynia 54.29 11.15 5 25756 178871 63284390
Systemic lupus erythematosus 53.51 11.15 10 25751 208908 63254353
Synovitis 52.26 11.15 7 25754 186911 63276350
Arthropathy 50.85 11.15 16 25745 234776 63228485
Peritoneal dialysis complication 50.81 11.15 19 25742 1201 63462060
Contraindicated product administered 50.52 11.15 13 25748 217635 63245626
Joint swelling 50.10 11.15 36 25725 327630 63135631
Kidney transplant rejection 48.89 11.15 27 25734 4244 63459017
Completed suicide 47.23 11.15 3 25758 145670 63317591
Hyperphosphataemia 45.79 11.15 21 25740 2227 63461034
Blood creatinine increased 45.27 11.15 106 25655 87738 63375523
Skin induration 44.26 11.15 23 25738 3200 63460061
Hyperparathyroidism tertiary 44.19 11.15 8 25753 21 63463240
Hyperparathyroidism secondary 43.97 11.15 18 25743 1449 63461812
Renal transplant 41.59 11.15 17 25744 1363 63461898
Drug hypersensitivity 41.49 11.15 241 25520 310446 63152815
Anaemia 40.74 11.15 230 25531 293200 63170061
Skin hypertrophy 40.37 11.15 22 25739 3369 63459892
Blood phosphorus increased 39.10 11.15 21 25740 3124 63460137
Brown tumour 38.94 11.15 8 25753 48 63463213
Infusion related reaction 38.80 11.15 26 25735 245495 63217766
Therapeutic product effect decreased 38.66 11.15 15 25746 193172 63270089
Hyperparathyroidism 35.99 11.15 19 25742 2730 63460531
Hepatic enzyme increased 35.37 11.15 19 25742 202309 63260952
Pericarditis 34.32 11.15 6 25755 131573 63331688
Alopecia 33.78 11.15 53 25708 337483 63125778
Hungry bone syndrome 33.13 11.15 8 25753 108 63463153
Hospitalisation 31.79 11.15 91 25670 84990 63378271
Acute myocardial infarction 30.28 11.15 50 25711 32074 63431187
Pulmonary renal syndrome 30.13 11.15 10 25751 444 63462817
Hypervitaminosis D 29.91 11.15 7 25754 82 63463179
Dialysis 29.16 11.15 28 25733 10399 63452862
Wound 29.02 11.15 15 25746 163248 63300013
Fungal peritonitis 28.63 11.15 10 25751 519 63462742
Septic shock 28.61 11.15 75 25686 66554 63396707
Skin tightness 28.06 11.15 19 25742 4297 63458964
Nephrolithiasis 27.71 11.15 56 25705 41928 63421333
Muscle spasms 27.60 11.15 131 25630 156019 63307242
Skin fibrosis 27.06 11.15 11 25750 869 63462392
Lower respiratory tract infection 26.92 11.15 10 25751 132297 63330964
Parathyroidectomy 26.64 11.15 8 25753 255 63463006
Sinusitis 26.25 11.15 32 25729 226621 63236640
Peritoneal dialysis 26.24 11.15 9 25752 442 63462819
Unresponsive to stimuli 25.85 11.15 48 25713 33768 63429493
Pain 25.54 11.15 186 25575 740442 62722819
Abdominal discomfort 25.40 11.15 58 25703 320827 63142434
Hypervolaemia 23.85 11.15 42 25719 28371 63434890
Paraesthesia oral 23.83 11.15 34 25727 19222 63444039
Product use issue 23.62 11.15 33 25728 220487 63242774
Metabolic alkalosis 23.62 11.15 15 25746 3046 63460215
Swelling 23.26 11.15 48 25713 275330 63187931
Arthralgia 23.20 11.15 136 25625 569574 62893687
Haemodialysis 23.10 11.15 23 25738 8924 63454337
Anti-erythropoietin antibody positive 23.08 11.15 8 25753 406 63462855
Calcinosis 22.87 11.15 13 25748 2159 63461102
Mental status changes 22.85 11.15 50 25711 39549 63423712
End stage renal disease 22.66 11.15 20 25741 6673 63456588
Pulse absent 22.18 11.15 18 25743 5356 63457905
Blood potassium increased 22.17 11.15 32 25729 18277 63444984
Parathyroid tumour benign 21.75 11.15 9 25752 744 63462517
Coagulation test abnormal 21.25 11.15 9 25752 789 63462472
Discomfort 21.16 11.15 22 25739 167352 63295909
Irritable bowel syndrome 20.96 11.15 4 25757 82408 63380853
Blood urea increased 20.87 11.15 38 25723 26341 63436920
Azotaemia 20.65 11.15 16 25745 4455 63458806
Impaired healing 20.44 11.15 8 25753 102534 63360727
Maternal exposure during pregnancy 19.75 11.15 37 25724 220025 63243236
Hyperparathyroidism primary 19.51 11.15 7 25754 393 63462868
Chronic kidney disease-mineral and bone disorder 18.97 11.15 5 25756 98 63463163
Diabetic foot 18.94 11.15 10 25751 1437 63461824
Rash 18.74 11.15 142 25619 560729 62902532
Hypoglycaemia 18.45 11.15 60 25701 60005 63403256
Intentional overdose 18.03 11.15 4 25757 74148 63389113
Hypersensitivity 17.86 11.15 60 25701 292625 63170636
Vascular parkinsonism 17.74 11.15 5 25756 127 63463134
Haemoglobin decreased 17.55 11.15 110 25651 145375 63317886
Polyhydramnios 17.20 11.15 11 25750 2260 63461001
Bone pain 17.16 11.15 55 25706 54586 63408675
Alveolar bone resorption 16.71 11.15 4 25757 52 63463209
Urinary tract infection 16.48 11.15 172 25589 264512 63198749
Fibromyalgia 16.48 11.15 6 25755 80414 63382847
Arrhythmia 16.43 11.15 43 25718 38097 63425164
Daydreaming 16.39 11.15 6 25755 357 63462904
Parathyroid disorder 16.10 11.15 7 25754 654 63462607
Electrolyte imbalance 15.98 11.15 29 25732 20047 63443214
Hypertension 15.78 11.15 178 25583 279125 63184136
Urine calcium increased 15.76 11.15 4 25757 67 63463194
Sepsis 15.59 11.15 111 25650 153012 63310249
Blister 15.37 11.15 18 25743 129796 63333465
Arteriovenous fistula thrombosis 15.06 11.15 5 25756 222 63463039
Musculoskeletal stiffness 14.89 11.15 33 25728 184585 63278676
Papillary thyroid cancer 14.83 11.15 10 25751 2246 63461015
Anti-neutrophil cytoplasmic antibody positive vasculitis 14.77 11.15 11 25750 2888 63460373
Cerebral infarction 14.74 11.15 31 25730 23862 63439399
Renal tubular necrosis 14.73 11.15 21 25740 11857 63451404
Product supply issue 14.54 11.15 9 25752 1746 63461515
Blood magnesium decreased 14.45 11.15 22 25739 13176 63450085
Fatigue 14.39 11.15 264 25497 887764 62575497
Vomiting 14.35 11.15 312 25449 559305 62903956
Staphylococcal infection 14.32 11.15 43 25718 41213 63422048
Gastrointestinal haemorrhage 14.25 11.15 68 25693 81108 63382153
Diffuse alopecia 13.92 11.15 7 25754 909 63462352
Drug abuse 13.90 11.15 6 25755 72512 63390749
Hypocalcaemic seizure 13.85 11.15 3 25758 24 63463237
Nephrotic syndrome 13.78 11.15 14 25747 5562 63457699
Simple partial seizures 13.74 11.15 6 25755 567 63462694
Asthenia 13.66 11.15 225 25536 383379 63079882
Nephropathy toxic 13.63 11.15 18 25743 9461 63453800
Loss of personal independence in daily activities 13.20 11.15 12 25749 97278 63365983
Bone metabolism biochemical marker increased 13.16 11.15 3 25758 31 63463230
Cardiac arrest 13.10 11.15 73 25688 92472 63370789
Nasopharyngitis 12.99 11.15 56 25705 254201 63209060
Encapsulating peritoneal sclerosis 12.95 11.15 5 25756 345 63462916
Psoriatic arthropathy 12.77 11.15 11 25750 91509 63371752
Paraesthesia 12.76 11.15 108 25653 156858 63306403
Peripheral swelling 12.74 11.15 60 25701 265882 63197379
Cardio-respiratory arrest 12.61 11.15 53 25708 59906 63403355
Urosepsis 12.57 11.15 25 25736 18499 63444762
Gingival hypertrophy 12.42 11.15 8 25753 1663 63461598
Iron deficiency 12.41 11.15 15 25746 7215 63456046
Dehydration 12.41 11.15 116 25645 173238 63290023
Sleep disorder 12.39 11.15 9 25752 81557 63381704
Suicidal ideation 12.22 11.15 5 25756 62416 63400845
Cerebral calcification 12.20 11.15 4 25757 171 63463090
International normalised ratio increased 12.18 11.15 44 25717 46381 63416880
Hypotension 12.06 11.15 166 25595 272438 63190823
Suicide attempt 11.74 11.15 5 25756 60913 63402348
Osteoarthritis 11.52 11.15 13 25748 95330 63367931
Ultrafiltration failure 11.43 11.15 4 25757 209 63463052
Incision site impaired healing 11.37 11.15 4 25757 212 63463049
Haemodialysis complication 11.34 11.15 4 25757 214 63463047
Bloody peritoneal effluent 11.23 11.15 3 25758 62 63463199
Knee arthroplasty 11.18 11.15 4 25757 54202 63409059

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 335.00 13.41 148 23868 8453 34924462
Appendicitis 288.76 13.41 159 23857 14648 34918267
Cardiogenic shock 210.11 13.41 162 23854 26456 34906459
Blood phosphorus increased 196.22 13.41 99 23917 7622 34925293
Peritonitis bacterial 193.30 13.41 91 23925 6019 34926896
Stress 183.24 13.41 158 23858 30189 34902726
Ascites 142.99 13.41 168 23848 46403 34886512
Shunt stenosis 141.65 13.41 42 23974 740 34932175
Hypercalcaemia 137.22 13.41 101 23915 15367 34917548
Abdominal distension 133.52 13.41 182 23834 58310 34874605
Ventricular fibrillation 131.46 13.41 116 23900 22838 34910077
Shunt occlusion 128.77 13.41 40 23976 830 34932085
Hypocalcaemia 125.81 13.41 116 23900 24173 34908742
Blood parathyroid hormone increased 125.61 13.41 45 23971 1469 34931446
Arteriovenous fistula site complication 124.89 13.41 34 23982 433 34932482
Multiple organ dysfunction syndrome 105.72 13.41 189 23827 76377 34856538
Drug hypersensitivity 105.13 13.41 194 23822 80335 34852580
General physical health deterioration 94.16 13.41 245 23771 128024 34804891
Nephrocalcinosis 88.42 13.41 28 23988 620 34932295
Abdominal pain 80.41 13.41 271 23745 163347 34769568
Blood uric acid increased 79 13.41 60 23956 9564 34923351
Recalled product 77.80 13.41 22 23994 325 34932590
Vomiting 76.24 13.41 354 23662 247267 34685648
Dry mouth 72.02 13.41 96 23920 30069 34902846
Hyponatraemia 71.22 13.41 168 23848 82523 34850392
Constipation 70.03 13.41 230 23786 136752 34796163
Nephrogenic systemic fibrosis 69.85 13.41 40 23976 3965 34928950
Sepsis 69.09 13.41 261 23755 166300 34766615
Peritoneal dialysis complication 68.41 13.41 30 23986 1679 34931236
Hypercalciuria 66.79 13.41 19 23997 287 34932628
Drug ineffective 66.46 13.41 134 23882 456617 34476298
Peritonitis 65.69 13.41 68 23948 16297 34916618
Hyperphosphataemia 63.49 13.41 39 23977 4398 34928517
Aplasia pure red cell 63.47 13.41 44 23972 6088 34926827
Chronic kidney disease 54.61 13.41 100 23916 41110 34891805
Mean platelet volume increased 52.58 13.41 18 23998 512 34932403
Hyperparathyroidism secondary 51.58 13.41 24 23992 1544 34931371
Hyperparathyroidism 50.67 13.41 22 23994 1202 34931713
Hypervolaemia 49.00 13.41 64 23952 19645 34913270
Myasthenia gravis 45.67 13.41 38 23978 6902 34926013
Zoonotic bacterial infection 45.13 13.41 10 24006 49 34932866
Hypophosphataemia 42.79 13.41 45 23971 10981 34921934
Hospitalisation 41.97 13.41 109 23907 56793 34876122
Nephrectomy 41.94 13.41 17 23999 781 34932134
Mycobacterium marinum infection 41.21 13.41 13 24003 284 34932631
Ventricular hyperkinesia 40.87 13.41 12 24004 204 34932711
Mycobacterium test positive 40.58 13.41 14 24002 408 34932507
Hypochromasia 40.22 13.41 13 24003 308 34932607
Calciphylaxis 39.96 13.41 18 23998 1074 34931841
Febrile neutropenia 38.74 13.41 23 23993 136826 34796089
Right atrial enlargement 38.53 13.41 12 24004 251 34932664
Nausea 38.01 13.41 378 23638 339530 34593385
Lung diffusion test decreased 35.30 13.41 14 24002 607 34932308
Mitral valve thickening 33.77 13.41 12 24004 382 34932533
Blood calcium decreased 33.63 13.41 38 23978 10046 34922869
Tendon calcification 32.41 13.41 8 24008 67 34932848
Analgesic therapy 31.97 13.41 15 24001 983 34931932
Completed suicide 31.49 13.41 14 24002 98154 34834761
Drug therapy 30.06 13.41 15 24001 1126 34931789
Blood creatinine increased 29.24 13.41 136 23880 94840 34838075
Calcinosis 29.14 13.41 13 24003 758 34932157
Carotid arteriosclerosis 28.30 13.41 17 23999 1841 34931074
Narrow anterior chamber angle 28.11 13.41 8 24008 121 34932794
Toxicity to various agents 27.13 13.41 61 23955 200301 34732614
Left ventricular enlargement 27.06 13.41 12 24004 690 34932225
Hypertensive heart disease 26.63 13.41 18 23998 2390 34930525
Skin induration 26.01 13.41 17 23999 2134 34930781
Sleep disorder therapy 25.64 13.41 13 24003 1010 34931905
Shunt infection 25.37 13.41 7 24009 94 34932821
Hypophosphatasia 25.26 13.41 6 24010 42 34932873
Proteinuria 24.38 13.41 45 23971 18597 34914318
Anti-erythropoietin antibody positive 24.27 13.41 12 24004 883 34932032
Left atrial enlargement 24.15 13.41 12 24004 893 34932022
Blood urea increased 23.23 13.41 59 23957 30305 34902610
Peripheral arterial occlusive disease 22.83 13.41 24 23992 5850 34927065
Chronic kidney disease-mineral and bone disorder 22.66 13.41 9 24007 392 34932523
Blood cholesterol increased 22.48 13.41 46 23970 20497 34912418
Haemoglobin decreased 22.48 13.41 151 23865 120621 34812294
Skin fibrosis 22.44 13.41 12 24004 1040 34931875
Bronchiolitis 22.17 13.41 18 23998 3158 34929757
Hungry bone syndrome 21.85 13.41 6 24010 79 34932836
Granuloma 21.80 13.41 18 23998 3233 34929682
Haemodialysis 21.37 13.41 31 23985 10495 34922420
Blood iron decreased 21.18 13.41 22 23994 5291 34927624
Iron deficiency 20.94 13.41 22 23994 5359 34927556
Renal transplant 20.87 13.41 14 24002 1835 34931080
Skin tightness 20.62 13.41 15 24001 2238 34930677
Arthralgia 20.47 13.41 55 23961 169986 34762929
Hypervitaminosis D 20.43 13.41 4 24012 9 34932906
Myasthenic syndrome 20.22 13.41 9 24007 522 34932393
Joint contracture 20.13 13.41 14 24002 1947 34930968
Interstitial lung disease 19.87 13.41 10 24006 65272 34867643
Blood chloride increased 19.42 13.41 16 24000 2865 34930050
Renal transplant failure 19.16 13.41 11 24005 1095 34931820
Potentiating drug interaction 18.75 13.41 20 23996 4957 34927958
Skin hypertrophy 18.56 13.41 15 24001 2614 34930301
Haematocrit decreased 18.14 13.41 56 23960 32160 34900755
Obstruction 18.12 13.41 15 24001 2704 34930211
Suicidal ideation 18.09 13.41 3 24013 40385 34892530
Interstitial granulomatous dermatitis 17.35 13.41 6 24010 176 34932739
Lymphocyte count decreased 17.35 13.41 44 23972 22578 34910337
Incorrect route of product administration 17.15 13.41 34 23982 14811 34918104
Mucosal inflammation 17.01 13.41 3 24013 38619 34894296
Porphyria acute 16.90 13.41 7 24009 340 34932575
Hepatic cyst infection 16.72 13.41 4 24012 29 34932886
Parathyroidectomy 16.56 13.41 5 24011 94 34932821
Therapeutic product effect incomplete 16.53 13.41 7 24009 50534 34882381
Myopathy 16.52 13.41 29 23987 11525 34921390
Upper respiratory tract infection 16.38 13.41 55 23961 33004 34899911
Blood calcium increased 16.37 13.41 16 24000 3578 34929337
Electrocardiogram T wave inversion 16.33 13.41 13 24003 2218 34930697
Milk-alkali syndrome 16.08 13.41 8 24008 597 34932318
Lens dislocation 15.95 13.41 5 24011 107 34932808
Intentional product use issue 15.62 13.41 11 24005 59805 34873110
Blood erythropoietin decreased 15.56 13.41 3 24013 6 34932909
Blood 1,25-dihydroxycholecalciferol decreased 15.56 13.41 3 24013 6 34932909
Insomnia 15.42 13.41 30 23986 103877 34829038
Red cell distribution width increased 15.39 13.41 20 23996 6103 34926812
Disease progression 15.35 13.41 32 23984 108045 34824870
Intestinal prolapse 15.03 13.41 5 24011 130 34932785
Fibrosis 14.87 13.41 13 24003 2523 34930392
Arteriovenous fistula occlusion 14.71 13.41 5 24011 139 34932776
Anaemia 14.55 13.41 233 23783 233102 34699813
Incorrect dose administered 14.26 13.41 5 24011 40510 34892405
Reticulocyte count abnormal 14.24 13.41 3 24013 11 34932904
Bone deformity 14.15 13.41 4 24012 59 34932856
Renal impairment 14.04 13.41 112 23904 94401 34838514
Bacterial infection 13.94 13.41 34 23982 17029 34915886
Neutrophil count decreased 13.87 13.41 9 24007 51095 34881820
Zoonosis 13.84 13.41 3 24013 13 34932902
Serum ferritin increased 13.80 13.41 19 23997 6127 34926788
Azotaemia 13.72 13.41 17 23999 4950 34927965
Kidney transplant rejection 13.67 13.41 21 23995 7476 34925439
End stage renal disease 13.67 13.41 23 23993 8838 34924077
Blood alkaline phosphatase decreased 13.67 13.41 8 24008 826 34932089
Pyelonephritis 13.64 13.41 19 23997 6196 34926719
Diastolic dysfunction 13.61 13.41 19 23997 6208 34926707
Malignant neoplasm progression 13.43 13.41 25 23991 88021 34844894

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypercalcaemia 469.46 11.35 276 41184 38154 79664774
Recalled product 389.11 11.35 92 41368 862 79702066
Hypocalcaemia 379.66 11.35 266 41194 49658 79653270
Appendicolith 371.97 11.35 147 41313 8404 79694524
Peritonitis bacterial 352.60 11.35 146 41314 9421 79693507
Appendicitis 276.83 11.35 158 41302 20636 79682292
Shunt stenosis 269.27 11.35 74 41386 1317 79701611
Milk-alkali syndrome 231.33 11.35 66 41394 1354 79701574
Arteriovenous fistula site complication 230.90 11.35 61 41399 928 79702000
Blood phosphorus increased 230.50 11.35 111 41349 10236 79692692
Shunt occlusion 205.59 11.35 61 41399 1443 79701485
Calciphylaxis 204.02 11.35 76 41384 3694 79699234
Cardiogenic shock 201.28 11.35 170 41290 41744 79661184
Blood parathyroid hormone increased 159.58 11.35 62 41398 3383 79699545
Peritonitis 141.39 11.35 117 41343 27919 79675009
Drug hypersensitivity 140.05 11.35 406 41054 298510 79404418
Ventricular fibrillation 130.16 11.35 118 41342 31808 79671120
Ascites 128.95 11.35 177 41283 75385 79627543
Nephrogenic systemic fibrosis 116.14 11.35 59 41401 6101 79696827
Stress 116.03 11.35 173 41287 79439 79623489
Nephrocalcinosis 114.32 11.35 39 41421 1463 79701465
Multiple organ dysfunction syndrome 110.90 11.35 213 41247 120033 79582895
Abdominal distension 106.75 11.35 209 41251 119441 79583487
Sepsis 101.17 11.35 339 41121 269089 79433839
Drug ineffective 101.14 11.35 262 41198 1080651 78622277
Chronic kidney disease 95.31 11.35 143 41317 66011 79636917
Blood calcium decreased 92.97 11.35 98 41362 31721 79671207
Peritoneal dialysis complication 90.37 11.35 37 41423 2317 79700611
Hyperphosphataemia 89.02 11.35 50 41410 6326 79696602
Blood uric acid increased 87.34 11.35 65 41395 13295 79689633
Aplasia pure red cell 87.25 11.35 53 41407 7757 79695171
Hospitalisation 85.73 11.35 166 41294 94070 79608858
Completed suicide 76.64 11.35 17 41443 245750 79457178
Hyperparathyroidism secondary 73.08 11.35 33 41427 2627 79700301
Hyponatraemia 70.46 11.35 228 41232 177620 79525308
Rheumatoid arthritis 70.09 11.35 12 41448 208458 79494470
Tetany 69.15 11.35 32 41428 2696 79700232
General physical health deterioration 68.47 11.35 304 41156 274934 79427994
Hypercalciuria 65.61 11.35 20 41440 520 79702408
Vomiting 64.10 11.35 576 40884 665252 79037676
Drug abuse 62.78 11.35 6 41454 162685 79540243
Hyperparathyroidism 58.23 11.35 30 41430 3194 79699734
Joint swelling 57.33 11.35 40 41420 288606 79414322
Synovitis 57.01 11.35 6 41454 150728 79552200
Skin induration 56.52 11.35 33 41427 4492 79698436
Abdominal pain 55.83 11.35 370 41090 389199 79313729
Renal impairment 55.17 11.35 194 41266 157589 79545339
Blood creatinine increased 54.52 11.35 191 41269 154866 79548062
Renal failure 51.48 11.35 224 41236 200744 79502184
Hypervolaemia 51.38 11.35 85 41375 42605 79660323
Constipation 50.10 11.35 284 41176 282766 79420162
Hungry bone syndrome 49.62 11.35 13 41447 191 79702737
Blood calcium increased 49.52 11.35 42 41418 10358 79692570
Hypophosphataemia 47.23 11.35 55 41405 19858 79683070
Renal transplant 46.86 11.35 24 41436 2523 79700405
Skin hypertrophy 46.38 11.35 30 41430 4898 79698030
Zoonotic bacterial infection 46.34 11.35 10 41450 59 79702869
Arthralgia 46.33 11.35 148 41312 571655 79131273
Treatment failure 45.31 11.35 16 41444 170470 79532458
Blood calcium abnormal 43.86 11.35 19 41441 1370 79701558
Myasthenia gravis 43.48 11.35 39 41421 10360 79692568
Toxicity to various agents 43.28 11.35 97 41363 421443 79281485
Contraindicated product administered 43.23 11.35 14 41446 157524 79545404
Arthropathy 43.16 11.35 19 41441 177092 79525836
Hyperparathyroidism tertiary 43.08 11.35 8 41452 18 79702910
Mycobacterium marinum infection 42.95 11.35 14 41446 455 79702473
Calcinosis 42.69 11.35 22 41438 2343 79700585
Brown tumour 42.17 11.35 9 41451 50 79702878
Kidney transplant rejection 42.00 11.35 38 41422 10208 79692720
Infusion related reaction 41.75 11.35 35 41425 230202 79472726
Mean platelet volume increased 40.94 11.35 17 41443 1103 79701825
Intentional overdose 40.63 11.35 4 41456 105956 79596972
Ventricular hyperkinesia 40.31 11.35 12 41448 287 79702641
Alopecia 39.75 11.35 37 41423 231318 79471610
Hand deformity 39.65 11.35 4 41456 103915 79599013
Mycobacterium test positive 39.49 11.35 13 41447 436 79702492
Hepatic enzyme increased 39.40 11.35 23 41437 182587 79520341
Parathyroidectomy 39.34 11.35 11 41449 209 79702719
Skin fibrosis 39.01 11.35 18 41442 1506 79701422
Blood urea increased 38.45 11.35 81 41379 48709 79654219
Haemodialysis 37.88 11.35 47 41413 18121 79684807
Sinusitis 37.61 11.35 28 41432 195473 79507455
Chronic kidney disease-mineral and bone disorder 37.12 11.35 13 41447 528 79702400
Right atrial enlargement 37.02 11.35 12 41448 383 79702545
Glossodynia 36.88 11.35 5 41455 103332 79599596
Systemic lupus erythematosus 36.51 11.35 9 41451 121140 79581788
Skin tightness 36.39 11.35 27 41433 5495 79697433
Mitral valve thickening 36.10 11.35 12 41448 415 79702513
Drug intolerance 35.89 11.35 51 41409 264068 79438860
Analgesic therapy 35.83 11.35 15 41445 994 79701934
Therapeutic product effect decreased 34.84 11.35 21 41439 163842 79539086
End stage renal disease 34.56 11.35 37 41423 12183 79690745
Hypochromasia 33.92 11.35 13 41447 683 79702245
Tendon calcification 33.47 11.35 9 41451 147 79702781
Drug therapy 33.31 11.35 15 41445 1186 79701742
Peripheral arterial occlusive disease 32.63 11.35 30 41430 8228 79694700
Dialysis 32.61 11.35 44 41416 18418 79684510
Hypervitaminosis D 31.88 11.35 8 41452 98 79702830
Iron deficiency 31.44 11.35 33 41427 10621 79692307
Hypoparathyroidism 31.37 11.35 14 41446 1084 79701844
Febrile neutropenia 30.99 11.35 45 41415 230954 79471974
Anaemia 30.72 11.35 360 41100 444655 79258273
Proteinuria 30.45 11.35 58 41402 32444 79670484
Suicide attempt 29.63 11.35 4 41456 82928 79620000
Left ventricular enlargement 29.57 11.35 12 41448 734 79702194
Sleep disorder therapy 29.07 11.35 13 41447 1011 79701917
Pericarditis 29.06 11.35 9 41451 104227 79598701
Dry mouth 28.84 11.35 106 41354 87913 79615015
Hypertensive heart disease 28.70 11.35 21 41439 4185 79698743
Nephrectomy 27.94 11.35 16 41444 2099 79700829
Narrow anterior chamber angle 27.59 11.35 8 41452 174 79702754
Nausea 27.56 11.35 671 40789 956525 78746403
Rash 27.49 11.35 182 41278 578176 79124752
Left atrial enlargement 27.07 11.35 13 41447 1190 79701738
Anti-erythropoietin antibody positive 26.61 11.35 11 41449 706 79702222
Shunt infection 26.39 11.35 8 41452 204 79702724
Hypersensitivity 26.35 11.35 61 41399 262178 79440750
Acute myocardial infarction 26.28 11.35 94 41366 76942 79625986
Pain 26.18 11.35 237 41223 703565 78999363
Product use issue 26.11 11.35 43 41417 209779 79493149
Lung diffusion test decreased 26.02 11.35 13 41447 1297 79701631
Cardiac arrest 25.52 11.35 165 41295 171931 79530997
Parathyroid tumour benign 25.20 11.35 11 41449 808 79702120
Hypophosphatasia 25.11 11.35 6 41454 59 79702869
Fungal peritonitis 25.10 11.35 12 41448 1088 79701840
Peritoneal dialysis 24.73 11.35 11 41449 845 79702083
Carotid arteriosclerosis 24.58 11.35 16 41444 2640 79700288
Diabetic foot 24.48 11.35 18 41442 3614 79699314
Pulmonary renal syndrome 24.36 11.35 10 41450 630 79702298
Suicidal ideation 24.35 11.35 5 41455 76335 79626593
Helicobacter infection 23.44 11.35 4 41456 69700 79633228
Azotaemia 23.30 11.35 25 41435 8251 79694677
Urosepsis 23.25 11.35 46 41414 26449 79676479
Joint contracture 22.86 11.35 15 41445 2509 79700419
Fatigue 22.60 11.35 344 41116 929383 78773545
Unresponsive to stimuli 22.49 11.35 72 41388 55716 79647212
Paraesthesia oral 22.30 11.35 39 41421 20432 79682496
Myasthenic syndrome 21.73 11.35 10 41450 832 79702096
Intentional product use issue 21.02 11.35 29 41431 152083 79550845
Blood erythropoietin decreased 20.47 11.35 4 41456 13 79702915
Mucosal inflammation 20.23 11.35 7 41453 75573 79627355
Haemoglobin decreased 20.15 11.35 190 41270 221929 79480999
Irritable bowel syndrome 20.01 11.35 4 41456 62237 79640691
Renal cyst 20.01 11.35 31 41429 14701 79688227
Psoriatic arthropathy 19.58 11.35 8 41452 77991 79624937
Blister 19.47 11.35 20 41440 119456 79583472
Hepatic cyst infection 19.19 11.35 6 41454 170 79702758
Blood potassium increased 19.01 11.35 45 41415 29230 79673698
Arteriovenous fistula site infection 18.99 11.35 6 41454 176 79702752
Fibromyalgia 18.96 11.35 5 41455 64335 79638593
Renal transplant failure 18.92 11.35 12 41448 1895 79701033
Arteriovenous fistula occlusion 18.91 11.35 8 41452 544 79702384
Arteriovenous fistula thrombosis 18.65 11.35 8 41452 563 79702365
High density lipoprotein decreased 18.56 11.35 17 41443 4638 79698290
Cerebral calcification 18.53 11.35 6 41454 191 79702737
Neutropenia 18.35 11.35 82 41378 287628 79415300
Nasopharyngitis 18.29 11.35 69 41391 253812 79449116
Hypertension 18.25 11.35 257 41203 330735 79372193
Serum ferritin increased 18.20 11.35 24 41436 9823 79693105
Bronchiolitis 18.09 11.35 16 41444 4172 79698756
Acute kidney injury 17.98 11.35 374 41086 519030 79183898
Polyhydramnios 17.50 11.35 11 41449 1709 79701219
Musculoskeletal stiffness 17.34 11.35 41 41419 174967 79527961
Interstitial granulomatous dermatitis 17.31 11.35 6 41454 236 79702692
Wound 17.24 11.35 21 41439 116158 79586770
Metabolic alkalosis 17.14 11.35 16 41444 4473 79698455
Peripheral swelling 17.09 11.35 77 41383 269540 79433388
Potentiating drug interaction 17.09 11.35 22 41438 8797 79694131
Pulmonary calcification 17.09 11.35 7 41453 439 79702489
Blood chloride increased 17.09 11.35 17 41443 5139 79697789
Nephrogenic anaemia 17.04 11.35 15 41445 3887 79699041
Hyperparathyroidism primary 16.83 11.35 7 41453 456 79702472
Blood alkaline phosphatase decreased 16.82 11.35 11 41449 1829 79701099
Injection site pain 16.72 11.35 26 41434 129812 79573116
Vascular parkinsonism 16.63 11.35 5 41455 124 79702804
Granuloma 16.55 11.35 21 41439 8276 79694652
Electrolyte imbalance 16.42 11.35 44 41416 30837 79672091
Cognitive disorder 16.25 11.35 8 41452 69918 79633010
Haematocrit decreased 16.18 11.35 69 41391 61243 79641685
Gastrointestinal haemorrhage 15.79 11.35 131 41329 147588 79555340
Arthritis 15.77 11.35 22 41438 114858 79588070
Plasma cell myeloma 15.68 11.35 62 41398 53197 79649731
Asthma 15.61 11.35 29 41431 135066 79567862
Encapsulating peritoneal sclerosis 15.60 11.35 8 41452 843 79702085
Lens dislocation 15.56 11.35 5 41455 155 79702773
Bone deformity 15.12 11.35 6 41454 346 79702582
Abdominal discomfort 15.07 11.35 73 41387 250654 79452274
Bloody peritoneal effluent 14.99 11.35 5 41455 175 79702753
Refractory cytopenia with unilineage dysplasia 14.97 11.35 8 41452 917 79702011
Obstruction 14.91 11.35 15 41445 4595 79698333
Urticaria 14.90 11.35 48 41412 185153 79517775
Stomatitis 14.84 11.35 34 41426 146723 79556205
Injection site reaction 14.79 11.35 5 41455 54780 79648148
Coagulation test abnormal 14.69 11.35 9 41451 1336 79701592
Hypocalcaemic seizure 14.46 11.35 4 41456 73 79702855
Alveolar bone resorption 14.41 11.35 4 41456 74 79702854
Complications of transplanted kidney 14.13 11.35 17 41443 6349 79696579
Coma 14.09 11.35 19 41441 100630 79602298
Drug reaction with eosinophilia and systemic symptoms 13.98 11.35 8 41452 64236 79638692
Pyelonephritis 13.96 11.35 32 41428 20356 79682572
Anti-erythropoietin antibody 13.86 11.35 3 41457 18 79702910
Dialysis hypotension 13.84 11.35 4 41456 86 79702842
Weight increased 13.80 11.35 86 41374 277300 79425628
Gangrene 13.80 11.35 20 41440 8944 79693984
Osteoarthritis 13.79 11.35 15 41445 87294 79615634
Blood iron decreased 13.79 11.35 27 41433 15407 79687521
Myopathy 13.78 11.35 32 41428 20531 79682397
Low turnover osteopathy 13.74 11.35 10 41450 1976 79700952
Graft thrombosis 13.70 11.35 6 41454 444 79702484
Night sweats 13.64 11.35 5 41455 52090 79650838
Sedation 13.56 11.35 5 41455 51890 79651038
Hepatocellular injury 13.46 11.35 4 41456 47589 79655339
Zoonosis 13.34 11.35 3 41457 22 79702906
Nephrolithiasis 13.32 11.35 59 41401 53232 79649696
Bacterial infection 13.18 11.35 41 41419 31239 79671689
Cardio-respiratory arrest 13.11 11.35 99 41361 108411 79594517
Blood 1,25-dihydroxycholecalciferol decreased 13.11 11.35 3 41457 24 79702904
Fanconi syndrome acquired 13.07 11.35 11 41449 2683 79700245
Transplant failure 13.03 11.35 14 41446 4627 79698301
Electrocardiogram T wave inversion 13.01 11.35 15 41445 5357 79697571
Oxygen saturation decreased 12.96 11.35 30 41430 129017 79573911
Urine protein/creatinine ratio increased 12.83 11.35 8 41452 1226 79701702
Lumbar vertebral fracture 12.80 11.35 17 41443 7005 79695923
Diabetes mellitus 12.76 11.35 77 41383 78313 79624615
Staphylococcal infection 12.70 11.35 62 41398 58233 79644695
Bone pain 12.66 11.35 60 41400 55682 79647246
Therapeutic product effect incomplete 12.63 11.35 35 41425 141610 79561318
Bone metabolism biochemical marker increased 12.60 11.35 3 41457 29 79702899
Malignant neoplasm progression 12.58 11.35 33 41427 135957 79566971
Lymphocyte count decreased 12.31 11.35 53 41407 47236 79655692
Cardiac valve disease 12.20 11.35 15 41445 5726 79697202
Haemodialysis complication 12.15 11.35 5 41455 317 79702611
Blood 1,25-dihydroxycholecalciferol increased 12.09 11.35 3 41457 35 79702893
Depression 11.96 11.35 65 41395 216725 79486203
Neutrophil count decreased 11.92 11.35 19 41441 93940 79608988
Peritoneal cloudy effluent 11.90 11.35 5 41455 334 79702594
Diffuse alopecia 11.90 11.35 7 41453 966 79701962
Impaired healing 11.82 11.35 17 41443 87638 79615290
Growth retardation 11.70 11.35 9 41451 1934 79700994
Fibrosis 11.49 11.35 14 41446 5295 79697633
Disease progression 11.47 11.35 53 41407 184309 79518619
Lower respiratory tract infection 11.46 11.35 32 41428 129188 79573740
Infarction 11.44 11.35 13 41447 4569 79698359
Overdose 11.44 11.35 53 41407 184153 79518775
Blood parathyroid hormone abnormal 11.42 11.35 5 41455 370 79702558
Breast induration 11.39 11.35 3 41457 45 79702883

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CC04 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC D05AX03 DERMATOLOGICALS
ANTIPSORIATICS
ANTIPSORIATICS FOR TOPICAL USE
Other antipsoriatics for topical use
FDA CS M0004229 Cholecalciferol
MeSH PA D050071 Bone Density Conservation Agents
MeSH PA D002120 Calcium Channel Agonists
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018977 Micronutrients
MeSH PA D014662 Vasoconstrictor Agents
MeSH PA D014815 Vitamins
FDA EPC N0000175908 Vitamin D3 Analog
CHEBI has role CHEBI:24621 hormones
CHEBI has role CHEBI:25212 metabolites
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:38807 calcium channel agonists
CHEBI has role CHEBI:38808 calcium channel modulators
CHEBI has role CHEBI:50646 antiosteoporotic
CHEBI has role CHEBI:50733 Dietary Supplement
CHEBI has role CHEBI:50748 antipsoriatic drug
CHEBI has role CHEBI:50846 Immunologic factor
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypophosphatemia indication 4996001
Hypocalcemia indication 5291005
Renal osteodystrophy indication 16726004 DOID:13068
Hypoparathyroidism indication 36976004 DOID:11199
Plaque psoriasis indication 200965009
Hyperparathyroidism Secondary to Chronic Renal Failure indication
Hypocalcemia from End-Stage Renal Disease with Dialysis indication
Neonatal hypocalcemic tetany off-label use 18442000
Vitamin D deficiency off-label use 34713006
Rickets off-label use 41345002 DOID:10609
Familial x-linked hypophosphatemic vitamin D refractory rickets off-label use 82236004
Vitamin D Dependent Rickets off-label use
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Sarcoidosis contraindication 31541009 DOID:11335
Hypercalcemia contraindication 66931009 DOID:12678
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Hypercalcemia associated with Sarcoidosis contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.7 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
3MCG/GM VECTICAL GALDERMA LABS LP N022087 Jan. 23, 2009 RX OINTMENT TOPICAL July 17, 2023 NEW PATIENT POPULATION

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST EC50 8.40 WOMBAT-PK CHEMBL
Vitamin D 25-hydroxylase Enzyme WOMBAT-PK
Vitamin D-binding protein Secreted Kd 7.62 CHEMBL
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Enzyme WOMBAT-PK
Vitamin D3 receptor Transcription factor Ki 10.30 CHEMBL
Vitamin D3 receptor Transcription factor Ki 10.60 CHEMBL
Vitamin D3 receptor Transcription factor EC50 10.30 CHEMBL
Vitamin D3 receptor Nuclear hormone receptor Kd 10.15 CHEMBL
Vitamin D3 receptor A Nuclear hormone receptor EC50 8.26 CHEMBL
Vitamin D3 receptor Nuclear hormone receptor EC50 7 CHEMBL

External reference:

IDSource
4017800 VUID
N0000146161 NUI
D00129 KEGG_DRUG
152323 RXNORM
C0006674 UMLSCUI
CHEBI:17823 CHEBI
VDX PDB_CHEM_ID
CHEMBL846 ChEMBL_ID
D002117 MESH_DESCRIPTOR_UI
DB00136 DRUGBANK_ID
5280453 PUBCHEM_CID
C118756 MESH_SUPPLEMENTAL_RECORD_UI
4393 INN_ID
FXC9231JVH UNII
1311 MMSL
42410 MMSL
4324 MMSL
d03126 MMSL
259333003 SNOMEDCT_US
68206008 SNOMEDCT_US
4017800 VANDF
4021906 VANDF
2779 IUPHAR_LIGAND_ID
001017 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 0054-0007 CAPSULE 0.25 ug ORAL ANDA 22 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 0054-0007 CAPSULE 0.25 ug ORAL ANDA 22 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3120 SOLUTION 1 ug ORAL ANDA 23 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3120 SOLUTION 1 ug ORAL ANDA 23 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3120 SOLUTION 1 ug ORAL ANDA 23 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 0093-7352 CAPSULE, LIQUID FILLED 0.25 ug ORAL ANDA 26 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 0093-7352 CAPSULE, LIQUID FILLED 0.25 ug ORAL ANDA 26 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 0093-7353 CAPSULE, LIQUID FILLED 0.50 ug ORAL ANDA 26 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 0093-7353 CAPSULE, LIQUID FILLED 0.50 ug ORAL ANDA 26 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 0143-9728 INJECTION 1 ug INTRAVENOUS ANDA 24 sections
Vectical HUMAN PRESCRIPTION DRUG LABEL 1 0299-2012 OINTMENT 3 ug TOPICAL NDA 26 sections
Vectical HUMAN PRESCRIPTION DRUG LABEL 1 0299-2012 OINTMENT 3 ug TOPICAL NDA 26 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 17478-831 INJECTION 1 ug INTRAVENOUS ANDA 23 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 17478-831 INJECTION 1 ug INTRAVENOUS ANDA 23 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 17478-931 INJECTION 1 ug INTRAVENOUS ANDA 23 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 17478-931 INJECTION 1 ug INTRAVENOUS ANDA 23 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 17478-932 INJECTION 2 ug INTRAVENOUS ANDA 23 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 17478-932 INJECTION 2 ug INTRAVENOUS ANDA 23 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 17856-0723 CAPSULE 0.25 ug ORAL ANDA 21 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 17856-3120 SOLUTION 1 ug ORAL ANDA 25 sections
CALCITRIOL HUMAN PRESCRIPTION DRUG LABEL 1 23155-662 CAPSULE 0.25 ug ORAL ANDA 21 sections
CALCITRIOL HUMAN PRESCRIPTION DRUG LABEL 1 23155-662 CAPSULE 0.25 ug ORAL ANDA 21 sections
CALCITRIOL HUMAN PRESCRIPTION DRUG LABEL 1 23155-663 CAPSULE 0.50 ug ORAL ANDA 21 sections
CALCITRIOL HUMAN PRESCRIPTION DRUG LABEL 1 23155-663 CAPSULE 0.50 ug ORAL ANDA 21 sections
Rocaltrol HUMAN PRESCRIPTION DRUG LABEL 1 30698-143 CAPSULE, GELATIN COATED 0.25 ug ORAL NDA 24 sections
Rocaltrol HUMAN PRESCRIPTION DRUG LABEL 1 30698-144 CAPSULE, GELATIN COATED 0.50 ug ORAL NDA 24 sections
Rocaltrol HUMAN PRESCRIPTION DRUG LABEL 1 30698-911 SOLUTION 1 ug ORAL NDA 24 sections
Calcitriol HUMAN PRESCRIPTION DRUG LABEL 1 43353-034 CAPSULE 0.25 ug ORAL ANDA 26 sections
CALCITRIOL HUMAN PRESCRIPTION DRUG LABEL 1 43353-138 CAPSULE 0.25 ug ORAL NDA authorized generic 26 sections
Rocaltrol HUMAN PRESCRIPTION DRUG LABEL 1 43353-633 CAPSULE, GELATIN COATED 0.25 ug ORAL NDA 22 sections