calcitriol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
Vitamin D analogues/derivatives	466	32222-06-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: rocaltrol calcitriol Dihydroxyvitamin D3 topitriol 1,25-dihydroxyvitamin D3	The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption. Molecular weight: 416.65 Formula: C27H44O3 CLOGP: 6.04 LIPINSKI: 1 HAC: 3 HDO: 3 TPSA: 60.69 ALOGS: -4.80 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

rocaltrol
calcitriol
Dihydroxyvitamin D3
topitriol
1,25-dihydroxyvitamin D3

The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.

Molecular weight: 416.65
Formula: C27H44O3
CLOGP: 6.04
LIPINSKI: 1
HAC: 3
HDO: 3
TPSA: 60.69
ALOGS: -4.80
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
1	mcg	O
1	mcg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	8 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.00 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	61 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.25 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.31 mL/min/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	11 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Aug. 17, 1978	FDA	VALIDUS PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Recalled product	1059.89	11.57	216	23790	1172	56266889
Hypocalcaemia	689.20	11.57	305	23701	28455	56239606
Hypercalcaemia	475.35	11.57	227	23779	25184	56242877
Milk-alkali syndrome	227.20	11.57	54	23952	644	56267417
Peritonitis bacterial	180.35	11.57	70	23936	4663	56263398
Calciphylaxis	161.39	11.57	56	23950	2711	56265350
Blood calcium decreased	157.86	11.57	108	23898	23661	56244400
Tetany	150.06	11.57	47	23959	1645	56266416
Blood parathyroid hormone increased	132.49	11.57	49	23957	2856	56265205
Shunt stenosis	122.80	11.57	31	23975	482	56267579
Rheumatoid arthritis	115.25	11.57	14	23992	382590	55885471
Arteriovenous fistula site complication	114.05	11.57	29	23977	465	56267596
Blood calcium abnormal	105.44	11.57	33	23973	1152	56266909
Nephrocalcinosis	97.61	11.57	30	23976	985	56267076
Nephrogenic systemic fibrosis	92.98	11.57	43	23963	4422	56263639
Peritonitis	87.68	11.57	65	23941	16137	56251924
Hypoparathyroidism	83.72	11.57	24	23982	616	56267445
Hypercalciuria	82.13	11.57	20	23986	266	56267795
Shunt occlusion	80.73	11.57	23	23983	577	56267484
Renal failure	74.54	11.57	153	23853	110347	56157714
Chronic kidney disease	71.61	11.57	89	23917	41967	56226094
Blood calcium increased	68.65	11.57	43	23963	8111	56259950
Aplasia pure red cell	66.82	11.57	34	23972	4308	56263753
Acute kidney injury	65.15	11.57	238	23768	240525	56027536
Drug ineffective	63.03	11.57	193	23813	918796	55349265
Renal impairment	59.49	11.57	116	23890	80597	56187464
Systemic lupus erythematosus	50.80	11.57	8	23998	180070	56087991
Peritoneal dialysis complication	50.04	11.57	19	23987	1191	56266870
Infusion related reaction	49.31	11.57	14	23992	208917	56059144
Drug intolerance	48.91	11.57	26	23980	264792	56003269
Synovitis	48.24	11.57	6	24000	161299	56106762
Kidney transplant rejection	47.98	11.57	27	23979	4186	56263875
Hyperparathyroidism secondary	47.63	11.57	19	23987	1360	56266701
Glossodynia	47.27	11.57	5	24001	152453	56115608
Treatment failure	47.10	11.57	8	23998	170384	56097677
Contraindicated product administered	46.79	11.57	11	23995	186275	56081786
Blood creatinine increased	45.97	11.57	104	23902	80087	56187974
Completed suicide	45.30	11.57	3	24003	133830	56134231
Skin induration	44.61	11.57	23	23983	2995	56265066
Joint swelling	44.60	11.57	35	23971	289765	55978296
Arthropathy	44.42	11.57	15	23991	200260	56067801
Hyperphosphataemia	43.63	11.57	20	23986	2015	56266046
Renal transplant	41.63	11.57	17	23989	1293	56266768
Skin hypertrophy	40.47	11.57	22	23984	3188	56264873
Chronic kidney disease-mineral and bone disorder	39.64	11.57	11	23995	250	56267811
Hyperparathyroidism tertiary	39.32	11.57	7	23999	15	56268046
Blood phosphorus increased	37.73	11.57	20	23986	2756	56265305
Therapeutic product effect decreased	37.04	11.57	13	23993	169439	56098622
Anaemia	36.83	11.57	217	23789	267294	56000767
Hungry bone syndrome	33.76	11.57	8	23998	94	56267967
Brown tumour	33.72	11.57	7	23999	42	56268019
Hyperparathyroidism	33.34	11.57	18	23988	2574	56265487
Hospitalisation	32.11	11.57	87	23919	74913	56193148
Pulmonary renal syndrome	30.71	11.57	10	23996	397	56267664
Acute myocardial infarction	30.49	11.57	50	23956	30343	56237718
Pericarditis	30.34	11.57	5	24001	108918	56159143
Muscle spasms	29.95	11.57	127	23879	137244	56130817
Dialysis	29.69	11.57	28	23978	9674	56258387
Hypervitaminosis D	29.64	11.57	7	23999	81	56267980
Alopecia	29.39	11.57	50	23956	293408	55974653
Skin tightness	28.71	11.57	19	23987	3936	56264125
Pain	28.66	11.57	166	23840	663018	55605043
Hepatic enzyme increased	28.55	11.57	19	23987	171365	56096696
Fungal peritonitis	28.37	11.57	10	23996	507	56267554
Septic shock	27.48	11.57	72	23934	60763	56207298
Skin fibrosis	26.73	11.57	11	23995	853	56267208
Nephrolithiasis	26.69	11.57	53	23953	37282	56230779
Parathyroidectomy	26.53	11.57	8	23998	246	56267815
Peritoneal dialysis	26.17	11.57	9	23997	424	56267637
Lower respiratory tract infection	24.75	11.57	9	23997	114785	56153276
Hypervolaemia	24.51	11.57	42	23964	26416	56241645
Sinusitis	24.39	11.57	29	23977	197552	56070509
Metabolic alkalosis	23.91	11.57	15	23991	2836	56265225
Wound	23.64	11.57	15	23991	138789	56129272
End stage renal disease	23.37	11.57	20	23986	6091	56261970
Discomfort	23.23	11.57	16	23990	141745	56126316
Swelling	22.96	11.57	42	23964	239729	56028332
Haemodialysis	22.92	11.57	23	23983	8568	56259493
Abdominal discomfort	22.80	11.57	53	23953	277221	55990840
Anti-erythropoietin antibody positive	22.78	11.57	8	23998	401	56267660
Coagulation test abnormal	21.69	11.57	9	23997	713	56267348
Blood urea increased	21.56	11.57	38	23968	24435	56243626
Product use issue	21.21	11.57	29	23977	186012	56082049
Maternal exposure during pregnancy	20.18	11.57	31	23975	189522	56078539
Arthralgia	19.83	11.57	129	23877	501540	55766521
Blood potassium increased	19.52	11.57	30	23976	17231	56250830
Diabetic foot	19.29	11.57	10	23996	1317	56266744
Azotaemia	18.81	11.57	15	23991	4143	56263918
Hypertension	18.52	11.57	172	23834	244106	56023955
Hypoglycaemia	18.39	11.57	59	23947	55756	56212305
Vascular parkinsonism	18.30	11.57	5	24001	107	56267954
Calcinosis	17.93	11.57	11	23995	1999	56266062
Rash	17.41	11.57	131	23875	492916	55775145
Arrhythmia	17.37	11.57	43	23963	35040	56233021
Irritable bowel syndrome	17.26	11.57	4	24002	68454	56199607
Intentional overdose	17.13	11.57	4	24002	68113	56199948
Impaired healing	16.79	11.57	8	23998	86833	56181228
Drug hypersensitivity	16.65	11.57	185	23821	275020	55993041
Parathyroid disorder	16.64	11.57	7	23999	574	56267487
Daydreaming	16.60	11.57	6	24000	327	56267734
Alveolar bone resorption	16.58	11.57	4	24002	51	56268010
Haemoglobin decreased	16.02	11.57	105	23901	134032	56134029
Diffuse alopecia	15.98	11.57	7	23999	634	56267427
Electrolyte imbalance	15.88	11.57	28	23978	18005	56250056
Asthenia	15.78	11.57	219	23787	342754	55925307
Urine calcium increased	15.74	11.57	4	24002	64	56267997
Off label use	15.54	11.57	157	23849	556023	55712038
Mental status changes	15.54	11.57	43	23963	37458	56230603
Paraesthesia	15.49	11.57	102	23904	130412	56137649
Staphylococcal infection	15.45	11.57	43	23963	37575	56230486
Renal tubular necrosis	15.43	11.57	21	23985	10807	56257254
Anti-neutrophil cytoplasmic antibody positive vasculitis	15.42	11.57	11	23995	2572	56265489
Product supply issue	15.40	11.57	9	23997	1497	56266564
Blood magnesium decreased	15.39	11.57	22	23984	11852	56256209
Sepsis	15.23	11.57	107	23899	139733	56128328
Arteriovenous fistula thrombosis	15.20	11.57	5	24001	205	56267856
Drug abuse	15.08	11.57	5	24001	67605	56200456
Papillary thyroid cancer	14.92	11.57	10	23996	2114	56265947
Gastrointestinal haemorrhage	14.85	11.57	68	23938	75883	56192178
Therapeutic product effect incomplete	14.82	11.57	14	23992	106017	56162044
Bone pain	14.71	11.57	51	23955	50134	56217927
Hypersensitivity	14.63	11.57	58	23948	256350	56011711
Nephropathy toxic	14.43	11.57	18	23988	8509	56259552
Hypocalcaemic seizure	13.81	11.57	3	24003	23	56268038
Cerebral infarction	13.80	11.57	30	23976	22475	56245586
Nephrotic syndrome	13.79	11.57	14	23992	5286	56262775
Unresponsive to stimuli	13.77	11.57	37	23969	31688	56236373
Iron deficiency	13.57	11.57	15	23991	6241	56261820
Simple partial seizures	13.57	11.57	6	24000	555	56267506
Urosepsis	13.50	11.57	25	23981	16691	56251370
Gingival hypertrophy	13.15	11.57	8	23998	1432	56266629
Urinary tract infection	12.90	11.57	158	23848	240355	56027706
Vomiting	12.81	11.57	290	23716	497938	55770123
Encapsulating peritoneal sclerosis	12.79	11.57	5	24001	339	56267722
Cardio-respiratory arrest	12.71	11.57	52	23954	55269	56212792
Catarrh	12.40	11.57	5	24001	368	56267693
International normalised ratio increased	12.25	11.57	44	23962	43997	56224064
Cerebral calcification	12.14	11.57	4	24002	165	56267896
Cardiac arrest	11.83	11.57	70	23936	86244	56181817
Incision site impaired healing	11.74	11.57	4	24002	183	56267878
Suicide attempt	11.69	11.57	5	24001	57831	56210230
Suicidal ideation	11.66	11.57	5	24001	57737	56210324
Bloody peritoneal effluent	11.58	11.57	3	24003	52	56268009

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	269.87	13.06	112	21131	5619	31670482
Appendicitis	223.31	13.06	122	21121	11343	31664758
Peritonitis bacterial	196.09	13.06	90	21153	5762	31670339
Hypocalcaemia	157.33	13.06	125	21118	21853	31654248
Cardiogenic shock	150.96	13.06	123	21120	22285	31653816
Shunt stenosis	136.52	13.06	40	21203	693	31675408
Stress	133.51	13.06	120	21123	24821	31651280
Blood parathyroid hormone increased	133.33	13.06	46	21197	1376	31674725
Hypercalcaemia	129.87	13.06	93	21150	13907	31662194
Arteriovenous fistula site complication	129.15	13.06	34	21209	388	31675713
Shunt occlusion	123.06	13.06	38	21205	793	31675308
Blood phosphorus increased	110.90	13.06	56	21187	4426	31671675
Ascites	102.87	13.06	132	21111	40881	31635220
Abdominal distension	98.25	13.06	144	21099	50540	31625561
Nephrocalcinosis	91.70	13.06	28	21215	562	31675539
Recalled product	79.30	13.06	22	21221	310	31675791
Ventricular fibrillation	74.92	13.06	77	21166	18771	31657330
General physical health deterioration	73.78	13.06	204	21039	113231	31562870
Multiple organ dysfunction syndrome	71.85	13.06	148	21095	68055	31608046
Nephrogenic systemic fibrosis	71.25	13.06	40	21203	3915	31672186
Hypercalciuria	67.20	13.06	19	21224	288	31675813
Peritonitis	67.12	13.06	66	21177	15261	31660840
Peritoneal dialysis complication	66.96	13.06	29	21214	1615	31674486
Aplasia pure red cell	64.70	13.06	43	21200	5694	31670407
Abdominal pain	61.47	13.06	226	21017	145726	31530375
Vomiting	60.49	13.06	303	20940	223670	31452431
Chronic kidney disease	58.36	13.06	97	21146	37878	31638223
Drug hypersensitivity	54.71	13.06	138	21105	72461	31603640
Drug ineffective	54.59	13.06	115	21128	395458	31280643
Sepsis	53.99	13.06	223	21020	151706	31524395
Mean platelet volume increased	53.60	13.06	18	21225	495	31675606
Hyperparathyroidism secondary	53.15	13.06	24	21219	1477	31674624
Hospitalisation	51.15	13.06	107	21136	49700	31626401
Hyperparathyroidism	48.66	13.06	21	21222	1159	31674942
Constipation	48.03	13.06	187	21056	123804	31552297
Hypervolaemia	47.71	13.06	60	21183	18191	31657910
Zoonotic bacterial infection	45.37	13.06	10	21233	49	31676052
Hyponatraemia	41.43	13.06	126	21117	73673	31602428
Ventricular hyperkinesia	41.21	13.06	12	21231	203	31675898
Hypochromasia	41.03	13.06	13	21230	296	31675805
Mycobacterium marinum infection	40.98	13.06	13	21230	297	31675804
Calciphylaxis	40.40	13.06	18	21225	1073	31675028
Right atrial enlargement	39.96	13.06	12	21231	227	31675874
Nephrectomy	39.61	13.06	16	21227	747	31675354
Mycobacterium test positive	38.05	13.06	13	21230	377	31675724
Mitral valve thickening	34.37	13.06	12	21231	372	31675729
Tendon calcification	32.83	13.06	8	21235	65	31676036
Blood calcium decreased	32.77	13.06	36	21207	9458	31666643
Lung diffusion test decreased	32.68	13.06	13	21230	583	31675518
Hyperphosphataemia	31.65	13.06	20	21223	2429	31673672
Blood creatinine increased	30.99	13.06	130	21113	88948	31587153
Febrile neutropenia	30.89	13.06	22	21221	121827	31554274
Nausea	29.30	13.06	325	20918	307622	31368479
Haemoglobin decreased	28.59	13.06	150	21093	112525	31563576
Narrow anterior chamber angle	28.50	13.06	8	21235	118	31675983
Left ventricular enlargement	27.71	13.06	12	21231	668	31675433
Calcinosis	27.42	13.06	12	21231	685	31675416
Skin induration	27.05	13.06	17	21226	2045	31674056
Carotid arteriosclerosis	26.93	13.06	16	21227	1741	31674360
Completed suicide	26.70	13.06	14	21229	91500	31584601
Shunt infection	26.42	13.06	7	21236	82	31676019
Hypertensive heart disease	26.18	13.06	17	21226	2164	31673937
Left atrial enlargement	26.06	13.06	12	21231	773	31675328
Hypophosphatasia	25.40	13.06	6	21237	42	31676059
Anti-erythropoietin antibody positive	24.96	13.06	12	21231	852	31675249
Blood uric acid increased	23.47	13.06	25	21218	6345	31669756
Peripheral arterial occlusive disease	23.40	13.06	23	21220	5310	31670791
Skin fibrosis	23.15	13.06	12	21231	1001	31675100
Haemodialysis	23.09	13.06	31	21212	10014	31666087
Chronic kidney disease-mineral and bone disorder	23.03	13.06	9	21234	385	31675716
Blood urea increased	22.71	13.06	56	21187	28956	31647145
Skin tightness	22.27	13.06	15	21228	2029	31674072
Renal transplant	22.27	13.06	14	21229	1685	31674416
Blood iron decreased	22.04	13.06	21	21222	4669	31671432
Granuloma	21.73	13.06	17	21226	2900	31673201
Joint contracture	21.51	13.06	14	21229	1789	31674312
Hypophosphataemia	20.68	13.06	27	21216	8487	31667614
Hypervitaminosis D	20.53	13.06	4	21239	9	31676092
Haematocrit decreased	20.41	13.06	55	21188	30006	31646095
Blood chloride increased	20.22	13.06	16	21227	2775	31673326
Renal transplant failure	20.15	13.06	11	21232	1019	31675082
Dry mouth	19.99	13.06	48	21195	24410	31651691
Skin hypertrophy	19.75	13.06	15	21228	2450	31673651
Bronchiolitis	19.66	13.06	16	21227	2888	31673213
Lymphocyte count decreased	19.61	13.06	43	21200	20606	31655495
Proteinuria	19.56	13.06	38	21205	16725	31659376
Toxicity to various agents	18.62	13.06	61	21182	181426	31494675
Red cell distribution width increased	17.71	13.06	20	21223	5414	31670687
Interstitial granulomatous dermatitis	17.56	13.06	6	21237	174	31675927
Electrocardiogram T wave inversion	17.54	13.06	13	21230	2047	31674054
Milk-alkali syndrome	17.30	13.06	8	21235	520	31675581
Porphyria acute	17.20	13.06	7	21236	333	31675768
Obstruction	17.14	13.06	13	21230	2119	31673982
Interstitial lung disease	17.03	13.06	10	21233	61393	31614708
Parathyroidectomy	16.99	13.06	5	21238	88	31676013
Hungry bone syndrome	16.93	13.06	5	21238	89	31676012
Blood 1,25-dihydroxycholecalciferol decreased	16.85	13.06	3	21240	3	31676098
Hepatic cyst infection	16.81	13.06	4	21239	29	31676072
Lens dislocation	16.34	13.06	5	21238	101	31676000
Fibrosis	15.74	13.06	13	21230	2396	31673705
Blood erythropoietin decreased	15.63	13.06	3	21240	6	31676095
Intestinal prolapse	15.61	13.06	5	21238	118	31675983
Pyelonephritis	15.42	13.06	19	21224	5637	31670464
Arteriovenous fistula occlusion	14.94	13.06	5	21238	136	31675965
Kidney transplant rejection	14.53	13.06	21	21222	7261	31668840
Bone deformity	14.44	13.06	4	21239	56	31676045
Rheumatoid arthritis	14.41	13.06	7	21236	47802	31628299
Reticulocyte count abnormal	14.31	13.06	3	21240	11	31676090
Blood alkaline phosphatase decreased	14.14	13.06	8	21235	794	31675307
Arthralgia	14.11	13.06	53	21190	151371	31524730
Zoonosis	14.11	13.06	3	21240	12	31676089
Cardiac arrest	14.04	13.06	105	21138	88957	31587144
Mucosal inflammation	13.96	13.06	3	21240	34424	31641677
Renal cyst	13.59	13.06	22	21221	8394	31667707
Potentiating drug interaction	13.57	13.06	16	21227	4537	31671564
Serum ferritin increased	13.50	13.06	18	21225	5774	31670327
Insomnia	13.47	13.06	27	21216	94809	31581292
Product use issue	13.41	13.06	11	21232	56748	31619353
Arteriovenous fistula site infection	13.25	13.06	4	21239	77	31676024
Azotaemia	13.18	13.06	16	21227	4676	31671425
Diastolic dysfunction	13.09	13.06	17	21226	5318	31670783

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypocalcaemia	454.35	11.22	287	37053	44572	70846532
Hypercalcaemia	449.03	11.22	259	37081	34126	70856978
Recalled product	388.56	11.22	92	37248	856	70890248
Peritonitis bacterial	343.04	11.22	142	37198	9042	70882062
Appendicolith	293.32	11.22	111	37229	5569	70885535
Shunt stenosis	258.68	11.22	71	37269	1241	70889863
Arteriovenous fistula site complication	234.72	11.22	61	37279	856	70890248
Milk-alkali syndrome	213.26	11.22	60	37280	1153	70889951
Appendicitis	205.00	11.22	121	37219	16612	70874492
Shunt occlusion	186.70	11.22	56	37284	1359	70889745
Blood parathyroid hormone increased	166.19	11.22	63	37277	3174	70887930
Calciphylaxis	161.88	11.22	63	37277	3410	70887694
Peritonitis	140.86	11.22	114	37226	26045	70865059
Cardiogenic shock	140.43	11.22	131	37209	36176	70854928
Blood phosphorus increased	133.18	11.22	67	37273	6703	70884401
Nephrocalcinosis	116.51	11.22	39	37301	1362	70889742
Nephrogenic systemic fibrosis	116.43	11.22	59	37281	5993	70885111
Rheumatoid arthritis	111.29	11.22	12	37328	291793	70599311
Chronic kidney disease	99.78	11.22	141	37199	60916	70830188
Hospitalisation	97.43	11.22	164	37176	82404	70808700
Drug ineffective	95.84	11.22	222	37118	939530	69951574
Blood calcium decreased	94.46	11.22	95	37245	28751	70862353
Peritoneal dialysis complication	90.82	11.22	37	37303	2259	70888845
Ascites	88.94	11.22	141	37199	67406	70823698
Aplasia pure red cell	86.85	11.22	52	37288	7322	70883782
Sepsis	80.40	11.22	297	37043	244248	70646856
Tetany	77.94	11.22	33	37307	2221	70888883
Stress	77.53	11.22	133	37207	67833	70823271
Hyperparathyroidism secondary	77.14	11.22	34	37306	2524	70888580
Multiple organ dysfunction syndrome	74.89	11.22	172	37168	108343	70782761
Abdominal distension	74.56	11.22	168	37172	104501	70786603
Drug hypersensitivity	71.11	11.22	300	37040	262159	70628945
Completed suicide	69.55	11.22	17	37323	227118	70663986
Ventricular fibrillation	68.80	11.22	78	37262	27033	70864071
Hypercalciuria	66.60	11.22	20	37320	487	70890617
Drug abuse	58.89	11.22	5	37335	147251	70743853
Skin induration	57.74	11.22	33	37307	4262	70886842
Chronic kidney disease-mineral and bone disorder	57.10	11.22	19	37321	651	70890453
Hyperparathyroidism	56.56	11.22	29	37311	3018	70888086
Blood creatinine increased	55.88	11.22	184	37156	142817	70748287
General physical health deterioration	54.99	11.22	258	37082	235773	70655331
Hypervolaemia	52.41	11.22	83	37257	39623	70851481
Vomiting	52.01	11.22	508	36832	592603	70298501
Renal impairment	50.79	11.22	179	37161	143758	70747346
Synovitis	50.03	11.22	5	37335	129223	70761881
Hyperphosphataemia	49.96	11.22	30	37310	4246	70886858
Drug intolerance	49.02	11.22	29	37311	225658	70665446
Renal transplant	48.05	11.22	24	37316	2364	70888740
Infusion related reaction	47.91	11.22	22	37318	197512	70693592
Joint swelling	47.73	11.22	38	37302	253173	70637931
Skin hypertrophy	47.62	11.22	30	37310	4622	70886482
Zoonotic bacterial infection	46.22	11.22	10	37330	59	70891045
Hungry bone syndrome	45.30	11.22	12	37328	182	70890922
Renal failure	45.00	11.22	208	37132	188862	70702242
Mycobacterium marinum infection	43.11	11.22	14	37326	444	70890660
Kidney transplant rejection	42.52	11.22	38	37302	9923	70881181
Blood calcium increased	41.78	11.22	36	37304	8957	70882147
Calcinosis	41.70	11.22	21	37319	2104	70889000
Mean platelet volume increased	41.46	11.22	17	37323	1055	70890049
Abdominal pain	41.44	11.22	315	37025	341812	70549292
Ventricular hyperkinesia	41.24	11.22	12	37328	261	70890843
Blood calcium abnormal	40.95	11.22	18	37322	1327	70889777
Treatment failure	40.00	11.22	13	37327	144129	70746975
Parathyroidectomy	39.87	11.22	11	37329	196	70890908
Hyponatraemia	39.48	11.22	178	37162	159909	70731195
Skin fibrosis	39.48	11.22	18	37322	1447	70889657
Hyperparathyroidism tertiary	39.24	11.22	7	37333	11	70891093
Haemodialysis	39.11	11.22	47	37293	17319	70873785
Hypoparathyroidism	38.94	11.22	16	37324	998	70890106
Right atrial enlargement	38.79	11.22	12	37328	324	70890780
Skin tightness	38.06	11.22	27	37313	5063	70886041
Intentional overdose	37.61	11.22	4	37336	98431	70792673
Contraindicated product administered	37.60	11.22	12	37328	134600	70756504
Blood urea increased	37.60	11.22	78	37262	45831	70845273
Brown tumour	37.45	11.22	8	37332	44	70891060
Mitral valve thickening	36.38	11.22	12	37328	400	70890704
Mycobacterium test positive	36.12	11.22	12	37328	409	70890695
Arthralgia	35.24	11.22	141	37199	503249	70387855
Arthropathy	34.42	11.22	18	37322	150039	70741065
Hypochromasia	34.17	11.22	13	37327	661	70890443
Tendon calcification	33.82	11.22	9	37331	139	70890965
Toxicity to various agents	33.57	11.22	97	37243	382075	70509029
End stage renal disease	33.42	11.22	35	37305	11098	70880006
Dialysis	32.66	11.22	43	37297	17359	70873745
Systemic lupus erythematosus	32.42	11.22	7	37333	101895	70789209
Alopecia	32.39	11.22	34	37306	198456	70692648
Hand deformity	31.82	11.22	4	37336	86478	70804626
Hypervitaminosis D	31.63	11.22	8	37332	100	70891004
Sinusitis	31.11	11.22	26	37314	169169	70721935
Peripheral arterial occlusive disease	30.78	11.22	28	37312	7481	70883623
Hepatic enzyme increased	30.28	11.22	23	37317	156967	70734137
Left ventricular enlargement	29.92	11.22	12	37328	703	70890401
Blood uric acid increased	29.76	11.22	30	37310	9099	70882005
Constipation	29.74	11.22	231	37109	252207	70638897
Glossodynia	29.51	11.22	5	37335	86482	70804622
Febrile neutropenia	29.06	11.22	39	37301	204279	70686825
Therapeutic product effect decreased	28.82	11.22	20	37320	142998	70748106
Suicide attempt	28.49	11.22	4	37336	79506	70811598
Left atrial enlargement	28.42	11.22	13	37327	1053	70890051
Acute myocardial infarction	27.74	11.22	93	37247	72794	70818310
Narrow anterior chamber angle	27.72	11.22	8	37332	169	70890935
Shunt infection	27.72	11.22	8	37332	169	70890935
Hypertensive heart disease	27.51	11.22	20	37320	3896	70887208
Nephrectomy	27.36	11.22	15	37325	1788	70889316
Anti-erythropoietin antibody positive	26.74	11.22	11	37329	688	70890416
Cardiac arrest	26.40	11.22	159	37181	159675	70731429
Diabetic foot	26.36	11.22	18	37322	3176	70887928
Proteinuria	25.34	11.22	51	37289	29323	70861781
Fungal peritonitis	25.25	11.22	12	37328	1060	70890044
Hypophosphatasia	25.13	11.22	6	37334	58	70891046
Pulmonary renal syndrome	25.10	11.22	10	37330	576	70890528
Peritoneal dialysis	25.01	11.22	11	37329	812	70890292
Hypophosphataemia	24.17	11.22	36	37304	16290	70874814
Anaemia	24.13	11.22	321	37019	403102	70488002
Suicidal ideation	23.79	11.22	4	37336	69592	70821512
Joint contracture	23.77	11.22	15	37325	2317	70888787
Lung diffusion test decreased	23.55	11.22	12	37328	1233	70889871
Pain	23.43	11.22	215	37125	628601	70262503
Carotid arteriosclerosis	23.23	11.22	15	37325	2412	70888692
Haemoglobin decreased	23.19	11.22	186	37154	204973	70686131
Product use issue	22.99	11.22	37	37303	179900	70711204
Pericarditis	22.87	11.22	8	37332	84697	70806407
Rash	21.50	11.22	169	37171	510393	70380711
Therapeutic product effect incomplete	21.33	11.22	19	37321	119863	70771241
Azotaemia	20.85	11.22	23	37317	7730	70883374
Renal cyst	20.58	11.22	30	37310	13315	70877789
Blood erythropoietin decreased	20.42	11.22	4	37336	13	70891091
Swelling	20.33	11.22	43	37297	188496	70702608
High density lipoprotein decreased	20.18	11.22	17	37323	4102	70887002
Hypersensitivity	19.67	11.22	59	37281	229753	70661351
Renal transplant failure	19.61	11.22	12	37328	1756	70889348
Helicobacter infection	19.47	11.22	3	37337	55653	70835451
Hepatic cyst infection	19.15	11.22	6	37334	169	70890935
Hypertension	19.14	11.22	239	37101	295794	70595310
Arteriovenous fistula site infection	18.92	11.22	6	37334	176	70890928
Nausea	18.90	11.22	584	36756	851504	70039600
Arteriovenous fistula occlusion	18.86	11.22	8	37332	541	70890563
Arteriovenous fistula thrombosis	18.81	11.22	8	37332	544	70890560
Cerebral calcification	18.57	11.22	6	37334	187	70890917
Metabolic alkalosis	18.16	11.22	16	37324	4100	70887004
Gastrointestinal haemorrhage	18.00	11.22	129	37211	137279	70753825
Pulmonary calcification	17.91	11.22	7	37333	383	70890721
Acute kidney injury	17.62	11.22	349	36991	474275	70416829
Haematocrit decreased	17.48	11.22	68	37272	57190	70833914
Blood chloride increased	17.48	11.22	17	37323	4936	70886168
Blood potassium increased	17.40	11.22	42	37298	27284	70863820
Vascular parkinsonism	17.40	11.22	5	37335	104	70891000
Interstitial granulomatous dermatitis	17.36	11.22	6	37334	231	70890873
Blood alkaline phosphatase decreased	17.32	11.22	11	37329	1718	70889386
Mucosal inflammation	17.32	11.22	7	37333	67843	70823261
Bronchiolitis	17.18	11.22	15	37325	3799	70887305
Electrolyte imbalance	16.80	11.22	41	37299	26820	70864284
Urosepsis	16.54	11.22	38	37302	23911	70867193
Serum ferritin increased	16.51	11.22	22	37318	8983	70882121
Lens dislocation	16.23	11.22	5	37335	133	70890971
Fatigue	16.04	11.22	322	37018	823997	70067107
Psoriatic arthropathy	16.03	11.22	7	37333	64764	70826340
Granuloma	15.99	11.22	20	37320	7675	70883429
Nephrogenic anaemia	15.83	11.22	14	37326	3604	70887500
Encapsulating peritoneal sclerosis	15.63	11.22	8	37332	829	70890275
Neutropenia	15.55	11.22	76	37264	257080	70634024
Coagulation test abnormal	15.47	11.22	9	37331	1201	70889903
Asthma	15.27	11.22	25	37315	120768	70770336
Hypocalcaemic seizure	15.27	11.22	4	37336	58	70891046
Bloody peritoneal effluent	15.23	11.22	5	37335	164	70890940
Blood iron decreased	15.17	11.22	26	37314	13235	70877869
Irritable bowel syndrome	15.17	11.22	4	37336	50846	70840258
Staphylococcal infection	15.16	11.22	62	37278	53342	70837762
Refractory cytopenia with unilineage dysplasia	15.09	11.22	8	37332	892	70890212
Complications of transplanted kidney	14.93	11.22	17	37323	5917	70885187
Pyelonephritis	14.88	11.22	31	37309	18258	70872846
Drug reaction with eosinophilia and systemic symptoms	14.79	11.22	6	37334	58007	70833097
Diffuse alopecia	14.48	11.22	7	37333	642	70890462
Cognitive disorder	14.44	11.22	7	37333	60949	70830155
Alveolar bone resorption	14.41	11.22	4	37336	73	70891031
Nephrolithiasis	14.28	11.22	56	37284	47267	70843837
Zoonosis	14.28	11.22	3	37337	15	70891089
Low turnover osteopathy	14.11	11.22	10	37330	1872	70889232
Musculoskeletal stiffness	14.07	11.22	36	37304	147724	70743380
Graft thrombosis	13.97	11.22	6	37334	418	70890686
Anti-erythropoietin antibody	13.82	11.22	3	37337	18	70891086
Parathyroid tumour benign	13.82	11.22	7	37333	710	70890394
Urine protein/creatinine ratio increased	13.81	11.22	8	37332	1060	70890044
Obstruction	13.80	11.22	13	37327	3628	70887476
Unresponsive to stimuli	13.74	11.22	59	37281	51872	70839232
Peripheral swelling	13.68	11.22	71	37269	236492	70654612
Electrocardiogram T wave inversion	13.66	11.22	15	37325	5016	70886088
Blood 1,25-dihydroxycholecalciferol decreased	13.55	11.22	3	37337	20	70891084
Blister	13.47	11.22	20	37320	100506	70790598
Cardio-respiratory arrest	13.46	11.22	95	37245	100582	70790522
Injection site pain	13.38	11.22	26	37314	117593	70773511
Gangrene	13.28	11.22	19	37321	8290	70882814
Intentional product use issue	13.28	11.22	27	37313	120115	70770989
Nasopharyngitis	13.24	11.22	66	37274	222140	70668964
Hypoglycaemia	13.18	11.22	90	37250	94274	70796830
Lumbar vertebral fracture	13.15	11.22	16	37324	5971	70885133
Hepatocellular injury	13.06	11.22	4	37336	46087	70845017
Peritoneal cloudy effluent	13.00	11.22	5	37335	262	70890842
Injection site reaction	12.96	11.22	5	37335	49847	70841257
Wound	12.89	11.22	20	37320	98712	70792392
Cardiac valve disease	12.80	11.22	15	37325	5383	70885721
Lymphocyte count decreased	12.72	11.22	51	37289	43488	70847616
Growth retardation	12.71	11.22	9	37331	1683	70889421
Coma	12.58	11.22	18	37322	91826	70799278
Sleep disorder	12.51	11.22	11	37329	69861	70821243
Stomatitis	12.48	11.22	31	37309	128480	70762624
Urticaria	12.46	11.22	44	37296	163005	70728099
Blood triglycerides increased	12.28	11.22	30	37310	19634	70871470
Fibrosis	12.28	11.22	14	37326	4880	70886224
Infarction	12.14	11.22	13	37327	4229	70886875
Fibromyalgia	12.12	11.22	5	37335	47869	70843235
Potentiating drug interaction	12.08	11.22	18	37322	8146	70882958
Angina pectoris	12.06	11.22	54	37286	48329	70842775
Bone deformity	11.99	11.22	5	37335	324	70890780
Breast induration	11.83	11.22	3	37337	38	70891066
Neutrophil count decreased	11.82	11.22	16	37324	83540	70807564
Weight increased	11.73	11.22	77	37263	242254	70648850
Sedation	11.64	11.22	5	37335	46726	70844378
Intestinal prolapse	11.63	11.22	4	37336	152	70890952
Electrocardiogram ST segment elevation	11.59	11.22	17	37323	7587	70883517
Dyslalia	11.55	11.22	7	37333	1007	70890097
Fanconi syndrome acquired	11.50	11.22	10	37330	2517	70888587
Bone pain	11.40	11.22	55	37285	50767	70840337
Blood parathyroid hormone abnormal	11.38	11.22	5	37335	368	70890736
Oxygen saturation decreased	11.37	11.22	28	37312	116401	70774703
Malignant neoplasm progression	11.33	11.22	30	37310	121709	70769395
Medullary thyroid cancer	11.31	11.22	4	37336	165	70890939
Apparent mineralocorticoid excess	11.29	11.22	3	37337	46	70891058
Paraesthesia oral	11.25	11.22	25	37315	15392	70875712

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A11CC04	ALIMENTARY TRACT AND METABOLISM VITAMINS VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO Vitamin D and analogues
ATC	D05AX03	DERMATOLOGICALS ANTIPSORIATICS ANTIPSORIATICS FOR TOPICAL USE Other antipsoriatics for topical use
FDA CS	M0004229	Cholecalciferol
MeSH PA	D050071	Bone Density Conservation Agents
MeSH PA	D002120	Calcium Channel Agonists
MeSH PA	D000077264	Calcium-Regulating Hormones and Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D018977	Micronutrients
MeSH PA	D014662	Vasoconstrictor Agents
MeSH PA	D014815	Vitamins
FDA EPC	N0000175908	Vitamin D3 Analog
CHEBI has role	CHEBI:24621	hormones
CHEBI has role	CHEBI:25212	metabolites
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:38807	calcium channel agonists
CHEBI has role	CHEBI:38808	calcium channel modulators
CHEBI has role	CHEBI:50646	antiosteoporotic
CHEBI has role	CHEBI:50733	Dietary Supplement
CHEBI has role	CHEBI:50748	antipsoriatic drug
CHEBI has role	CHEBI:50846	Immunologic factor
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypophosphatemia	indication	4996001
Hypocalcemia	indication	5291005
Renal osteodystrophy	indication	16726004	DOID:13068
Hypoparathyroidism	indication	36976004	DOID:11199
Plaque psoriasis	indication	200965009
Hyperparathyroidism Secondary to Chronic Renal Failure	indication
Hypocalcemia from End-Stage Renal Disease with Dialysis	indication
Neonatal hypocalcemic tetany	off-label use	18442000
Vitamin D deficiency	off-label use	34713006
Rickets	off-label use	41345002	DOID:10609
Familial x-linked hypophosphatemic vitamin D refractory rickets	off-label use	82236004
Vitamin D Dependent Rickets	off-label use
Hyperphosphatemia	contraindication	20165001	DOID:0050459
Hypervitaminosis D	contraindication	27712000	DOID:9971
Sarcoidosis	contraindication	31541009	DOID:11335
Hypercalcemia	contraindication	66931009	DOID:12678
Kidney disease	contraindication	90708001	DOID:557
Kidney stone	contraindication	95570007
Arteriosclerosis obliterans	contraindication	361133006	DOID:5160
Hypercalcemia associated with Sarcoidosis	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.7	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Exclusivity date	Description
3MCG/GM	VECTICAL	GALDERMA LABS LP	N022087	Jan. 23, 2009	RX	OINTMENT	TOPICAL	July 17, 2023	NEW PATIENT POPULATION

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Vitamin D3 receptor	Nuclear hormone receptor	P11473	VDR_HUMAN	AGONIST	EC50	8.40	WOMBAT-PK	CHEMBL
Vitamin D 25-hydroxylase	Enzyme	Q6VVX0	CP2R1_HUMAN				WOMBAT-PK
Vitamin D-binding protein	Secreted	P02774	VTDB_HUMAN		Kd	7.62	CHEMBL
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	Enzyme	O15528	CP27B_HUMAN				WOMBAT-PK
Vitamin D3 receptor	Transcription factor		VDR_RAT		Ki	10.30	CHEMBL
Vitamin D3 receptor	Transcription factor		VDR_CHICK		Ki	10.60	CHEMBL
Vitamin D3 receptor	Transcription factor		VDR_BOVIN		EC50	10.30	CHEMBL
Vitamin D3 receptor	Nuclear hormone receptor		VDR_PIG		Kd	10.15	CHEMBL
Vitamin D3 receptor A	Nuclear hormone receptor		VDRA_DANRE		EC50	8.26	CHEMBL
Vitamin D3 receptor	Nuclear hormone receptor		VDR_MOUSE		EC50	7	CHEMBL

External reference:

ID	Source
4017800	VUID
N0000146161	NUI
D00129	KEGG_DRUG
152323	RXNORM
4017800	VANDF
4021906	VANDF
C0006674	UMLSCUI
CHEBI:17823	CHEBI
VDX	PDB_CHEM_ID
CHEMBL846	ChEMBL_ID
D002117	MESH_DESCRIPTOR_UI
DB00136	DRUGBANK_ID
5280453	PUBCHEM_CID
C118756	MESH_SUPPLEMENTAL_RECORD_UI
2779	IUPHAR_LIGAND_ID
4393	INN_ID
FXC9231JVH	UNII
1311	MMSL
42410	MMSL
4324	MMSL
d03126	MMSL
001017	NDDF
259333003	SNOMEDCT_US
68206008	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0007	CAPSULE	0.25 ug	ORAL	ANDA	22 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0007	CAPSULE	0.25 ug	ORAL	ANDA	22 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	0054-3120	SOLUTION	1 ug	ORAL	ANDA	23 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	0054-3120	SOLUTION	1 ug	ORAL	ANDA	23 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7352	CAPSULE, LIQUID FILLED	0.25 ug	ORAL	ANDA	26 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7352	CAPSULE, LIQUID FILLED	0.25 ug	ORAL	ANDA	26 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7353	CAPSULE, LIQUID FILLED	0.50 ug	ORAL	ANDA	26 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7353	CAPSULE, LIQUID FILLED	0.50 ug	ORAL	ANDA	26 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9728	INJECTION	1 ug	INTRAVENOUS	ANDA	24 sections
Vectical	HUMAN PRESCRIPTION DRUG LABEL	1	0299-2012	OINTMENT	3 ug	TOPICAL	NDA	26 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	17478-831	INJECTION	1 ug	INTRAVENOUS	ANDA	23 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	17478-831	INJECTION	1 ug	INTRAVENOUS	ANDA	23 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	17478-931	INJECTION	1 ug	INTRAVENOUS	ANDA	23 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	17478-931	INJECTION	1 ug	INTRAVENOUS	ANDA	23 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	17478-932	INJECTION	2 ug	INTRAVENOUS	ANDA	23 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	17478-932	INJECTION	2 ug	INTRAVENOUS	ANDA	23 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	17856-0723	CAPSULE	0.25 ug	ORAL	ANDA	21 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	17856-3120	SOLUTION	1 ug	ORAL	ANDA	25 sections
CALCITRIOL	HUMAN PRESCRIPTION DRUG LABEL	1	23155-662	CAPSULE	0.25 ug	ORAL	ANDA	21 sections
CALCITRIOL	HUMAN PRESCRIPTION DRUG LABEL	1	23155-663	CAPSULE	0.50 ug	ORAL	ANDA	21 sections
Rocaltrol	HUMAN PRESCRIPTION DRUG LABEL	1	30698-143	CAPSULE, GELATIN COATED	0.25 ug	ORAL	NDA	24 sections
Rocaltrol	HUMAN PRESCRIPTION DRUG LABEL	1	30698-144	CAPSULE, GELATIN COATED	0.50 ug	ORAL	NDA	24 sections
Rocaltrol	HUMAN PRESCRIPTION DRUG LABEL	1	30698-911	SOLUTION	1 ug	ORAL	NDA	24 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	43353-034	CAPSULE	0.25 ug	ORAL	ANDA	26 sections
CALCITRIOL	HUMAN PRESCRIPTION DRUG LABEL	1	43353-138	CAPSULE	0.25 ug	ORAL	NDA authorized generic	26 sections
Rocaltrol	HUMAN PRESCRIPTION DRUG LABEL	1	43353-633	CAPSULE, GELATIN COATED	0.25 ug	ORAL	NDA	22 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	43353-998	CAPSULE, LIQUID FILLED	0.25 ug	ORAL	ANDA	25 sections
calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	45802-608	OINTMENT	3 ug	TOPICAL	NDA	25 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	51407-169	CAPSULE, LIQUID FILLED	0.25 ug	ORAL	ANDA	24 sections
Calcitriol	HUMAN PRESCRIPTION DRUG LABEL	1	51407-169	CAPSULE, LIQUID FILLED	0.25 ug	ORAL	ANDA	24 sections