Stem definition | Drug id | CAS RN |
---|---|---|
calcium metabolism regulator, pharmaceutical aid | 2387 | 105462-24-6 |
Dose | Unit | Route |
---|---|---|
5 | mg | O |
5 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 87 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.29 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 1 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 6.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.50 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.76 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 200 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
March 27, 1998 | FDA | WARNER CHILCOTT LLC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Femur fracture | 2208.03 | 31.20 | 444 | 2657 | 6295 | 2348689 |
Arthralgia | 1140.54 | 31.20 | 406 | 2695 | 53879 | 2301105 |
Fall | 1117.65 | 31.20 | 386 | 2715 | 46713 | 2308271 |
Atypical femur fracture | 1105.21 | 31.20 | 188 | 2913 | 914 | 2354070 |
Low turnover osteopathy | 971.42 | 31.20 | 168 | 2933 | 913 | 2354071 |
Stress fracture | 968.47 | 31.20 | 172 | 2929 | 1117 | 2353867 |
Osteonecrosis | 820.45 | 31.20 | 202 | 2899 | 7140 | 2347844 |
Pain in extremity | 749.46 | 31.20 | 281 | 2820 | 42259 | 2312725 |
Osteonecrosis of jaw | 743.66 | 31.20 | 190 | 2911 | 7806 | 2347178 |
Pathological fracture | 684.53 | 31.20 | 128 | 2973 | 1136 | 2353848 |
Osteoporosis | 660.64 | 31.20 | 154 | 2947 | 4260 | 2350724 |
Bone disorder | 644.39 | 31.20 | 143 | 2958 | 3149 | 2351835 |
Osteoarthritis | 581.55 | 31.20 | 152 | 2949 | 6794 | 2348190 |
Fracture displacement | 578.74 | 31.20 | 83 | 3018 | 77 | 2354907 |
Impaired healing | 563.65 | 31.20 | 141 | 2960 | 5270 | 2349714 |
Gastrooesophageal reflux disease | 531.82 | 31.20 | 150 | 2951 | 8945 | 2346039 |
Osteomyelitis | 512.82 | 31.20 | 121 | 2980 | 3512 | 2351472 |
Jaw disorder | 506.81 | 31.20 | 100 | 3001 | 1201 | 2353783 |
Myalgia | 440.55 | 31.20 | 163 | 2938 | 23170 | 2331814 |
Back pain | 423.08 | 31.20 | 172 | 2929 | 31487 | 2323497 |
Pain | 414.04 | 31.20 | 207 | 2894 | 61650 | 2293334 |
Bone pain | 408.40 | 31.20 | 122 | 2979 | 8874 | 2346110 |
Pain in jaw | 403.46 | 31.20 | 112 | 2989 | 6260 | 2348724 |
Fracture nonunion | 371.72 | 31.20 | 67 | 3034 | 469 | 2354515 |
Gait disturbance | 361.82 | 31.20 | 140 | 2961 | 22405 | 2332579 |
Foot fracture | 350.77 | 31.20 | 85 | 3016 | 2753 | 2352231 |
Condition aggravated | 347.17 | 31.20 | 150 | 2951 | 31829 | 2323155 |
Fracture delayed union | 308.66 | 31.20 | 53 | 3048 | 268 | 2354716 |
Tooth disorder | 305.03 | 31.20 | 82 | 3019 | 4041 | 2350943 |
Dental caries | 299.25 | 31.20 | 69 | 3032 | 1791 | 2353193 |
Arthritis | 296.64 | 31.20 | 98 | 3003 | 9870 | 2345114 |
Drug ineffective | 295.91 | 31.20 | 198 | 2903 | 101426 | 2253558 |
Depression | 292.07 | 31.20 | 128 | 2973 | 28004 | 2326980 |
Hypertension | 288.92 | 31.20 | 126 | 2975 | 27235 | 2327749 |
Tooth extraction | 288.14 | 31.20 | 72 | 3029 | 2648 | 2352336 |
Bursitis | 276.35 | 31.20 | 65 | 3036 | 1843 | 2353141 |
Rheumatoid arthritis | 275.50 | 31.20 | 110 | 2991 | 19030 | 2335954 |
Nausea | 266.52 | 31.20 | 193 | 2908 | 111996 | 2242988 |
Tooth fracture | 259.97 | 31.20 | 61 | 3040 | 1710 | 2353274 |
Oedema peripheral | 252.52 | 31.20 | 110 | 2991 | 23653 | 2331331 |
Spinal osteoarthritis | 244.71 | 31.20 | 58 | 3043 | 1699 | 2353285 |
Drug hypersensitivity | 244.46 | 31.20 | 133 | 2968 | 46510 | 2308474 |
Bone sequestrum | 236.72 | 31.20 | 44 | 3057 | 371 | 2354613 |
Arthropathy | 233.89 | 31.20 | 76 | 3025 | 7240 | 2347744 |
Osteoporotic fracture | 229.38 | 31.20 | 42 | 3059 | 323 | 2354661 |
Chest pain | 225.42 | 31.20 | 107 | 2994 | 28030 | 2326954 |
Anaemia postoperative | 223.39 | 31.20 | 43 | 3058 | 445 | 2354539 |
Vitamin D deficiency | 221.40 | 31.20 | 52 | 3049 | 1462 | 2353522 |
Mobility decreased | 216.16 | 31.20 | 75 | 3026 | 8735 | 2346249 |
Dyspepsia | 215.57 | 31.20 | 77 | 3024 | 9767 | 2345217 |
Bedridden | 213.68 | 31.20 | 50 | 3051 | 1382 | 2353602 |
Intramedullary rod insertion | 213.39 | 31.20 | 44 | 3057 | 662 | 2354322 |
Hiatus hernia | 209.83 | 31.20 | 53 | 3048 | 2031 | 2352953 |
Groin pain | 200.70 | 31.20 | 47 | 3054 | 1303 | 2353681 |
Tooth abscess | 200.07 | 31.20 | 51 | 3050 | 2028 | 2352956 |
Periodontal disease | 193.61 | 31.20 | 37 | 3064 | 367 | 2354617 |
Fracture | 190.94 | 31.20 | 52 | 3049 | 2679 | 2352305 |
Dysphagia | 188.82 | 31.20 | 75 | 3026 | 12730 | 2342254 |
Device failure | 188.18 | 31.20 | 47 | 3054 | 1718 | 2353266 |
Hyperlipidaemia | 182.68 | 31.20 | 50 | 3051 | 2624 | 2352360 |
Anaemia | 181.28 | 31.20 | 99 | 3002 | 34693 | 2320291 |
Lower limb fracture | 180.49 | 31.20 | 47 | 3054 | 2034 | 2352950 |
Anxiety | 179.60 | 31.20 | 93 | 3008 | 29266 | 2325718 |
Resorption bone increased | 179.15 | 31.20 | 32 | 3069 | 210 | 2354774 |
Asthenia | 179.14 | 31.20 | 109 | 2992 | 46817 | 2308167 |
Purulent discharge | 177.07 | 31.20 | 39 | 3062 | 814 | 2354170 |
Diverticulum | 175.89 | 31.20 | 43 | 3058 | 1436 | 2353548 |
Loss of personal independence in daily activities | 172.99 | 31.20 | 56 | 3045 | 5255 | 2349729 |
Abdominal discomfort | 169.60 | 31.20 | 76 | 3025 | 17380 | 2337604 |
Toothache | 169.34 | 31.20 | 47 | 3054 | 2597 | 2352387 |
Headache | 169.30 | 31.20 | 129 | 2972 | 80050 | 2274934 |
Osteopenia | 169.25 | 31.20 | 44 | 3057 | 1891 | 2353093 |
Exostosis | 168.64 | 31.20 | 41 | 3060 | 1337 | 2353647 |
Gingivitis | 167.38 | 31.20 | 41 | 3060 | 1380 | 2353604 |
Drug intolerance | 166.84 | 31.20 | 70 | 3031 | 13647 | 2341337 |
Vomiting | 161.72 | 31.20 | 120 | 2981 | 71482 | 2283502 |
Hypothyroidism | 161.60 | 31.20 | 51 | 3050 | 4406 | 2350578 |
Synovitis | 158.82 | 31.20 | 45 | 3056 | 2681 | 2352303 |
Infection | 157.80 | 31.20 | 73 | 3028 | 17956 | 2337028 |
Bone erosion | 157.79 | 31.20 | 33 | 3068 | 533 | 2354451 |
Spinal fracture | 157.33 | 31.20 | 45 | 3056 | 2774 | 2352210 |
Musculoskeletal pain | 154.59 | 31.20 | 62 | 3039 | 10768 | 2344216 |
Dizziness | 152.16 | 31.20 | 107 | 2994 | 58558 | 2296426 |
Fatigue | 152.06 | 31.20 | 124 | 2977 | 84749 | 2270235 |
Pyrexia | 151.10 | 31.20 | 103 | 2998 | 53605 | 2301379 |
Nodule | 149.13 | 31.20 | 41 | 3060 | 2185 | 2352799 |
Muscular weakness | 148.29 | 31.20 | 66 | 3035 | 14831 | 2340153 |
Joint swelling | 146.84 | 31.20 | 68 | 3033 | 16751 | 2338233 |
Periodontitis | 146.45 | 31.20 | 32 | 3069 | 642 | 2354342 |
Comminuted fracture | 146.29 | 31.20 | 23 | 3078 | 58 | 2354926 |
Atypical fracture | 145.72 | 31.20 | 25 | 3076 | 125 | 2354859 |
Tooth loss | 144.10 | 31.20 | 36 | 3065 | 1315 | 2353669 |
Muscle spasms | 139.48 | 31.20 | 71 | 3030 | 21495 | 2333489 |
Cellulitis | 139.38 | 31.20 | 55 | 3046 | 9146 | 2345838 |
Pelvic fracture | 138.50 | 31.20 | 35 | 3066 | 1340 | 2353644 |
Hypercholesterolaemia | 137.65 | 31.20 | 36 | 3065 | 1582 | 2353402 |
C-reactive protein increased | 137.04 | 31.20 | 49 | 3052 | 6206 | 2348778 |
Bone density decreased | 133.68 | 31.20 | 34 | 3067 | 1336 | 2353648 |
Intervertebral disc degeneration | 133.04 | 31.20 | 35 | 3066 | 1574 | 2353410 |
Oral pain | 132.01 | 31.20 | 41 | 3060 | 3356 | 2351628 |
Oesophagitis | 129.98 | 31.20 | 36 | 3065 | 1970 | 2353014 |
Loose tooth | 129.53 | 31.20 | 29 | 3072 | 653 | 2354331 |
Open reduction of fracture | 129.13 | 31.20 | 26 | 3075 | 344 | 2354640 |
Urinary tract infection | 125.50 | 31.20 | 74 | 3027 | 29868 | 2325116 |
Carpal tunnel syndrome | 125.07 | 31.20 | 35 | 3066 | 1990 | 2352994 |
Renal cyst | 124.63 | 31.20 | 31 | 3070 | 1111 | 2353873 |
Muscle fatigue | 122.26 | 31.20 | 25 | 3076 | 359 | 2354625 |
Hypoaesthesia | 120.42 | 31.20 | 63 | 3038 | 20152 | 2334832 |
Rotator cuff syndrome | 119.38 | 31.20 | 33 | 3068 | 1792 | 2353192 |
Malaise | 118.17 | 31.20 | 90 | 3011 | 55495 | 2299489 |
Cataract | 117.13 | 31.20 | 43 | 3058 | 5865 | 2349119 |
Oral infection | 117.10 | 31.20 | 28 | 3073 | 848 | 2354136 |
Hypersensitivity | 116.74 | 31.20 | 65 | 3036 | 23528 | 2331456 |
Constipation | 116.41 | 31.20 | 63 | 3038 | 21566 | 2333418 |
Bone graft | 115.09 | 31.20 | 22 | 3079 | 218 | 2354766 |
Mouth ulceration | 114.21 | 31.20 | 38 | 3063 | 3874 | 2351110 |
Chronic sinusitis | 112.64 | 31.20 | 25 | 3076 | 540 | 2354444 |
Insomnia | 108.70 | 31.20 | 64 | 3037 | 25723 | 2329261 |
Cough | 108.59 | 31.20 | 70 | 3031 | 33047 | 2321937 |
Gingival disorder | 108.21 | 31.20 | 25 | 3076 | 650 | 2354334 |
Chills | 105.71 | 31.20 | 53 | 3048 | 15499 | 2339485 |
Dental fistula | 104.17 | 31.20 | 19 | 3082 | 142 | 2354842 |
Therapeutic product effect variable | 103.82 | 31.20 | 19 | 3082 | 145 | 2354839 |
Abdominal pain | 103.77 | 31.20 | 69 | 3032 | 34305 | 2320679 |
Fistula discharge | 103.48 | 31.20 | 20 | 3081 | 211 | 2354773 |
Asthma | 102.56 | 31.20 | 47 | 3054 | 11267 | 2343717 |
Bone loss | 102.53 | 31.20 | 23 | 3078 | 522 | 2354462 |
Dyspnoea | 102.32 | 31.20 | 96 | 3005 | 78637 | 2276347 |
Exostosis of jaw | 102.08 | 31.20 | 21 | 3080 | 311 | 2354673 |
Diarrhoea | 101.22 | 31.20 | 98 | 3003 | 83466 | 2271518 |
Sleep apnoea syndrome | 101.16 | 31.20 | 30 | 3071 | 2096 | 2352888 |
Jaw fracture | 100.11 | 31.20 | 22 | 3079 | 453 | 2354531 |
Device breakage | 99.56 | 31.20 | 28 | 3073 | 1619 | 2353365 |
Oral disorder | 98.98 | 31.20 | 27 | 3074 | 1394 | 2353590 |
Gingival swelling | 98.49 | 31.20 | 24 | 3077 | 788 | 2354196 |
Decreased appetite | 96.97 | 31.20 | 62 | 3039 | 28829 | 2326155 |
Temporomandibular joint syndrome | 96.97 | 31.20 | 23 | 3078 | 672 | 2354312 |
Limb asymmetry | 95.61 | 31.20 | 18 | 3083 | 163 | 2354821 |
Immobile | 94.67 | 31.20 | 22 | 3079 | 587 | 2354397 |
Scoliosis | 93.91 | 31.20 | 24 | 3077 | 960 | 2354024 |
Pubis fracture | 93.71 | 31.20 | 20 | 3081 | 357 | 2354627 |
Adverse drug reaction | 93.03 | 31.20 | 40 | 3061 | 8243 | 2346741 |
Eczema | 93.01 | 31.20 | 31 | 3070 | 3174 | 2351810 |
Joint range of motion decreased | 91.84 | 31.20 | 27 | 3074 | 1829 | 2353155 |
Emphysema | 91.58 | 31.20 | 24 | 3077 | 1061 | 2353923 |
Tendonitis | 91.22 | 31.20 | 28 | 3073 | 2199 | 2352785 |
Gingival pain | 90.76 | 31.20 | 24 | 3077 | 1099 | 2353885 |
Tooth infection | 90.28 | 31.20 | 27 | 3074 | 1941 | 2353043 |
Neck pain | 89.17 | 31.20 | 38 | 3063 | 7659 | 2347325 |
Blood alkaline phosphatase increased | 88.23 | 31.20 | 36 | 3065 | 6509 | 2348475 |
Rib fracture | 87.11 | 31.20 | 28 | 3073 | 2557 | 2352427 |
Intervertebral disc protrusion | 86.60 | 31.20 | 29 | 3072 | 3012 | 2351972 |
Ankle fracture | 86.54 | 31.20 | 27 | 3074 | 2238 | 2352746 |
Gastritis | 85.83 | 31.20 | 32 | 3069 | 4549 | 2350435 |
Abdominal pain upper | 85.67 | 31.20 | 52 | 3049 | 22048 | 2332936 |
Vertigo | 85.08 | 31.20 | 39 | 3062 | 9345 | 2345639 |
Gait inability | 84.54 | 31.20 | 34 | 3067 | 5921 | 2349063 |
Abscess jaw | 84.08 | 31.20 | 18 | 3083 | 326 | 2354658 |
General physical health deterioration | 83.92 | 31.20 | 44 | 3057 | 14095 | 2340889 |
Red blood cell sedimentation rate increased | 83.85 | 31.20 | 26 | 3075 | 2111 | 2352873 |
Osteogenesis imperfecta | 83.35 | 31.20 | 14 | 3087 | 60 | 2354924 |
Gingival ulceration | 82.84 | 31.20 | 16 | 3085 | 168 | 2354816 |
Bone fragmentation | 82.60 | 31.20 | 15 | 3086 | 109 | 2354875 |
Hepatitis | 82.50 | 31.20 | 34 | 3067 | 6303 | 2348681 |
Osteitis | 81.85 | 31.20 | 20 | 3081 | 664 | 2354320 |
Swelling face | 81.53 | 31.20 | 38 | 3063 | 9455 | 2345529 |
Oral cavity fistula | 81.51 | 31.20 | 16 | 3085 | 184 | 2354800 |
Hysterectomy | 81.48 | 31.20 | 24 | 3077 | 1636 | 2353348 |
Musculoskeletal chest pain | 81.14 | 31.20 | 26 | 3075 | 2350 | 2352634 |
Eye pain | 80.21 | 31.20 | 31 | 3070 | 4860 | 2350124 |
Sinusitis | 80.20 | 31.20 | 45 | 3056 | 16481 | 2338503 |
Periprosthetic fracture | 80.15 | 31.20 | 14 | 3087 | 79 | 2354905 |
Iron deficiency anaemia | 80.10 | 31.20 | 25 | 3076 | 2074 | 2352910 |
Spinal disorder | 79.67 | 31.20 | 22 | 3079 | 1188 | 2353796 |
Gastric ulcer | 78.94 | 31.20 | 27 | 3074 | 2989 | 2351995 |
Hypercalcaemia | 78.92 | 31.20 | 26 | 3075 | 2566 | 2352418 |
Tibia fracture | 78.66 | 31.20 | 20 | 3081 | 783 | 2354201 |
Joint effusion | 78.51 | 31.20 | 22 | 3079 | 1254 | 2353730 |
Femoral neck fracture | 78.12 | 31.20 | 22 | 3079 | 1277 | 2353707 |
Adverse event | 76.29 | 31.20 | 34 | 3067 | 7625 | 2347359 |
Chronic obstructive pulmonary disease | 75.60 | 31.20 | 33 | 3068 | 7044 | 2347940 |
White blood cell count increased | 75.60 | 31.20 | 33 | 3068 | 7045 | 2347939 |
Ligament sprain | 75.54 | 31.20 | 22 | 3079 | 1441 | 2353543 |
Bruxism | 75.07 | 31.20 | 19 | 3082 | 730 | 2354254 |
Palpitations | 74.97 | 31.20 | 43 | 3058 | 16413 | 2338571 |
Therapeutic product effect incomplete | 74.78 | 31.20 | 37 | 3064 | 10494 | 2344490 |
Gastrointestinal disorder | 74.42 | 31.20 | 35 | 3066 | 8882 | 2346102 |
Nasal polyps | 74.30 | 31.20 | 15 | 3086 | 201 | 2354783 |
Weight decreased | 73.80 | 31.20 | 52 | 3049 | 28319 | 2326665 |
Atrial fibrillation | 73.69 | 31.20 | 40 | 3061 | 13728 | 2341256 |
Aortic arteriosclerosis | 73.24 | 31.20 | 18 | 3083 | 612 | 2354372 |
Foot deformity | 73.02 | 31.20 | 23 | 3078 | 1966 | 2353018 |
Osteosclerosis | 72.72 | 31.20 | 16 | 3085 | 331 | 2354653 |
Spondylolisthesis | 72.49 | 31.20 | 17 | 3084 | 472 | 2354512 |
Obstructive airways disorder | 72.45 | 31.20 | 21 | 3080 | 1352 | 2353632 |
Muscle strain | 72.26 | 31.20 | 20 | 3081 | 1089 | 2353895 |
Sinusitis fungal | 71.76 | 31.20 | 13 | 3088 | 93 | 2354891 |
Skeletal injury | 71.64 | 31.20 | 15 | 3086 | 243 | 2354741 |
Sciatica | 71.52 | 31.20 | 23 | 3078 | 2102 | 2352882 |
Blood cholesterol increased | 71.21 | 31.20 | 29 | 3072 | 5212 | 2349772 |
Spinal compression fracture | 70.43 | 31.20 | 22 | 3079 | 1829 | 2353155 |
Weight increased | 70.11 | 31.20 | 46 | 3055 | 22291 | 2332693 |
Inflammation | 69.72 | 31.20 | 30 | 3071 | 6183 | 2348801 |
Gamma-glutamyltransferase increased | 69.54 | 31.20 | 29 | 3072 | 5533 | 2349451 |
Hyperaesthesia teeth | 69.45 | 31.20 | 16 | 3085 | 410 | 2354574 |
Mastication disorder | 68.87 | 31.20 | 16 | 3085 | 426 | 2354558 |
Barrett's oesophagus | 68.75 | 31.20 | 15 | 3086 | 298 | 2354686 |
Tricuspid valve incompetence | 68.57 | 31.20 | 21 | 3080 | 1635 | 2353349 |
Balance disorder | 68.47 | 31.20 | 34 | 3067 | 9713 | 2345271 |
Radius fracture | 68.37 | 31.20 | 17 | 3084 | 607 | 2354377 |
Angina pectoris | 67.97 | 31.20 | 26 | 3075 | 3961 | 2351023 |
Salpingo-oophorectomy unilateral | 67.84 | 31.20 | 10 | 3091 | 13 | 2354971 |
Synovial cyst | 67.48 | 31.20 | 18 | 3083 | 852 | 2354132 |
Contraindicated product administered | 67.36 | 31.20 | 24 | 3077 | 2997 | 2351987 |
Loss of consciousness | 67.19 | 31.20 | 42 | 3059 | 18725 | 2336259 |
Blood urea increased | 66.85 | 31.20 | 25 | 3076 | 3580 | 2351404 |
Irritable bowel syndrome | 66.38 | 31.20 | 21 | 3080 | 1820 | 2353164 |
Interstitial lung disease | 66.22 | 31.20 | 31 | 3070 | 7781 | 2347203 |
Ulna fracture | 66.12 | 31.20 | 14 | 3087 | 240 | 2354744 |
Haematocrit decreased | 65.96 | 31.20 | 26 | 3075 | 4292 | 2350692 |
Fracture malunion | 65.70 | 31.20 | 11 | 3090 | 46 | 2354938 |
Sputum increased | 64.97 | 31.20 | 13 | 3088 | 166 | 2354818 |
Facial pain | 64.34 | 31.20 | 19 | 3082 | 1306 | 2353678 |
Cataract operation | 64.07 | 31.20 | 17 | 3084 | 788 | 2354196 |
Musculoskeletal stiffness | 63.91 | 31.20 | 35 | 3066 | 12212 | 2342772 |
Limb injury | 63.85 | 31.20 | 22 | 3079 | 2488 | 2352496 |
Chest discomfort | 63.43 | 31.20 | 37 | 3064 | 14558 | 2340426 |
Calcium deficiency | 63.21 | 31.20 | 13 | 3088 | 192 | 2354792 |
Diastolic dysfunction | 62.98 | 31.20 | 16 | 3085 | 624 | 2354360 |
Humerus fracture | 62.74 | 31.20 | 18 | 3083 | 1117 | 2353867 |
Multiple fractures | 62.61 | 31.20 | 16 | 3085 | 639 | 2354345 |
Gingival recession | 62.55 | 31.20 | 14 | 3087 | 314 | 2354670 |
Contusion | 62.44 | 31.20 | 35 | 3066 | 12775 | 2342209 |
Deep vein thrombosis | 62.13 | 31.20 | 35 | 3066 | 12897 | 2342087 |
Atrophy | 62.05 | 31.20 | 14 | 3087 | 326 | 2354658 |
Bone lesion | 62.04 | 31.20 | 16 | 3085 | 663 | 2354321 |
Respiratory symptom | 61.94 | 31.20 | 13 | 3088 | 213 | 2354771 |
Hyperparathyroidism | 61.82 | 31.20 | 15 | 3086 | 483 | 2354501 |
Hip arthroplasty | 61.70 | 31.20 | 20 | 3081 | 1874 | 2353110 |
Cardiomegaly | 60.95 | 31.20 | 21 | 3080 | 2375 | 2352609 |
Bone marrow oedema | 60.89 | 31.20 | 12 | 3089 | 141 | 2354843 |
Acute kidney injury | 60.55 | 31.20 | 46 | 3055 | 28076 | 2326908 |
Dental necrosis | 59.86 | 31.20 | 11 | 3090 | 86 | 2354898 |
Swelling | 59.55 | 31.20 | 37 | 3064 | 16313 | 2338671 |
Red blood cell count decreased | 59.30 | 31.20 | 24 | 3077 | 4242 | 2350742 |
Paraesthesia | 58.59 | 31.20 | 41 | 3060 | 22047 | 2332937 |
Haemoglobin decreased | 58.45 | 31.20 | 38 | 3063 | 18113 | 2336871 |
Joint dislocation | 58.31 | 31.20 | 18 | 3083 | 1438 | 2353546 |
Blood loss anaemia | 58.14 | 31.20 | 17 | 3084 | 1128 | 2353856 |
Haemorrhoids | 57.91 | 31.20 | 20 | 3081 | 2277 | 2352707 |
Aspartate aminotransferase increased | 57.53 | 31.20 | 33 | 3068 | 12579 | 2342405 |
Hip fracture | 56.99 | 31.20 | 24 | 3077 | 4688 | 2350296 |
Joint injury | 56.86 | 31.20 | 20 | 3081 | 2404 | 2352580 |
Embolism venous | 56.62 | 31.20 | 13 | 3088 | 328 | 2354656 |
Liver disorder | 56.05 | 31.20 | 26 | 3075 | 6388 | 2348596 |
Dry mouth | 55.63 | 31.20 | 28 | 3073 | 8225 | 2346759 |
Type V hyperlipidaemia | 54.55 | 31.20 | 10 | 3091 | 77 | 2354907 |
Nephrolithiasis | 54.48 | 31.20 | 23 | 3078 | 4520 | 2350464 |
Large intestine polyp | 54.42 | 31.20 | 16 | 3085 | 1082 | 2353902 |
Meniscus injury | 54.42 | 31.20 | 16 | 3085 | 1082 | 2353902 |
Pulpitis dental | 53.57 | 31.20 | 11 | 3090 | 161 | 2354823 |
Influenza like illness | 53.39 | 31.20 | 31 | 3070 | 12083 | 2342901 |
Jaundice | 53.39 | 31.20 | 24 | 3077 | 5484 | 2349500 |
Trismus | 53.31 | 31.20 | 15 | 3086 | 867 | 2354117 |
Abscess | 53.01 | 31.20 | 19 | 3082 | 2412 | 2352572 |
Oesophageal stenosis | 52.97 | 31.20 | 13 | 3088 | 439 | 2354545 |
Hypotension | 52.70 | 31.20 | 45 | 3056 | 32391 | 2322593 |
Gastrointestinal haemorrhage | 52.64 | 31.20 | 31 | 3070 | 12404 | 2342580 |
Uveitis | 52.48 | 31.20 | 17 | 3084 | 1588 | 2353396 |
Metaphyseal corner fracture | 52.38 | 31.20 | 7 | 3094 | 1 | 2354983 |
Gingival bleeding | 52.22 | 31.20 | 18 | 3083 | 2037 | 2352947 |
Malocclusion | 52.11 | 31.20 | 9 | 3092 | 47 | 2354937 |
Female genital tract fistula | 52.01 | 31.20 | 13 | 3088 | 474 | 2354510 |
Herpes zoster | 51.29 | 31.20 | 28 | 3073 | 9697 | 2345287 |
Walking aid user | 51.19 | 31.20 | 14 | 3087 | 728 | 2354256 |
Vertebral foraminal stenosis | 50.78 | 31.20 | 10 | 3091 | 117 | 2354867 |
Pre-existing condition improved | 50.70 | 31.20 | 13 | 3088 | 526 | 2354458 |
Cerumen impaction | 50.53 | 31.20 | 11 | 3090 | 216 | 2354768 |
Impaired work ability | 50.48 | 31.20 | 17 | 3084 | 1793 | 2353191 |
Spinal stenosis | 50.39 | 31.20 | 16 | 3085 | 1402 | 2353582 |
Patellofemoral pain syndrome | 50.39 | 31.20 | 10 | 3091 | 122 | 2354862 |
Joint stiffness | 50.36 | 31.20 | 21 | 3080 | 4002 | 2350982 |
Candida infection | 49.91 | 31.20 | 19 | 3082 | 2854 | 2352130 |
Blood lactate dehydrogenase increased | 49.79 | 31.20 | 20 | 3081 | 3464 | 2351520 |
Diverticulitis | 49.65 | 31.20 | 21 | 3080 | 4144 | 2350840 |
Fibrocystic breast disease | 49.52 | 31.20 | 11 | 3090 | 238 | 2354746 |
Abdominal distension | 49.51 | 31.20 | 28 | 3073 | 10383 | 2344601 |
Dehydration | 49.14 | 31.20 | 37 | 3064 | 22258 | 2332726 |
Weight bearing difficulty | 48.62 | 31.20 | 12 | 3089 | 415 | 2354569 |
Cholecystectomy | 48.18 | 31.20 | 16 | 3085 | 1616 | 2353368 |
Fibromyalgia | 47.36 | 31.20 | 19 | 3082 | 3281 | 2351703 |
Wrist fracture | 47.33 | 31.20 | 16 | 3085 | 1707 | 2353277 |
Wound dehiscence | 47.28 | 31.20 | 13 | 3088 | 690 | 2354294 |
Parkinson's disease | 47.28 | 31.20 | 15 | 3086 | 1311 | 2353673 |
Procedural pain | 47.25 | 31.20 | 16 | 3085 | 1716 | 2353268 |
Oral herpes | 47.22 | 31.20 | 17 | 3084 | 2185 | 2352799 |
Medical device removal | 47.18 | 31.20 | 12 | 3089 | 470 | 2354514 |
Wheezing | 46.99 | 31.20 | 23 | 3078 | 6361 | 2348623 |
Radiculopathy | 46.76 | 31.20 | 13 | 3088 | 719 | 2354265 |
Essential hypertension | 46.74 | 31.20 | 12 | 3089 | 488 | 2354496 |
Hand fracture | 46.69 | 31.20 | 13 | 3088 | 723 | 2354261 |
Sleep disorder | 46.63 | 31.20 | 23 | 3078 | 6466 | 2348518 |
Oesophageal ulcer | 46.56 | 31.20 | 13 | 3088 | 730 | 2354254 |
Fungal infection | 46.42 | 31.20 | 21 | 3080 | 4868 | 2350116 |
Lymphadenopathy | 46.39 | 31.20 | 22 | 3079 | 5676 | 2349308 |
Agranulocytosis | 46.37 | 31.20 | 19 | 3082 | 3463 | 2351521 |
Dyspnoea exertional | 46.31 | 31.20 | 22 | 3079 | 5698 | 2349286 |
Uterine disorder | 45.96 | 31.20 | 12 | 3089 | 522 | 2354462 |
Stomatitis | 45.86 | 31.20 | 26 | 3075 | 9684 | 2345300 |
Road traffic accident | 45.70 | 31.20 | 20 | 3081 | 4288 | 2350696 |
Tenderness | 45.65 | 31.20 | 16 | 3085 | 1902 | 2353082 |
Heart rate irregular | 45.60 | 31.20 | 17 | 3084 | 2410 | 2352574 |
Exposed bone in jaw | 45.20 | 31.20 | 13 | 3088 | 813 | 2354171 |
Cholestasis | 45.15 | 31.20 | 19 | 3082 | 3702 | 2351282 |
Mitral valve incompetence | 44.78 | 31.20 | 17 | 3084 | 2533 | 2352451 |
Breast disorder | 44.58 | 31.20 | 11 | 3090 | 380 | 2354604 |
Therapeutic response unexpected | 44.48 | 31.20 | 19 | 3082 | 3840 | 2351144 |
Alanine aminotransferase increased | 44.23 | 31.20 | 29 | 3072 | 14003 | 2340981 |
Pulmonary fibrosis | 44.21 | 31.20 | 17 | 3084 | 2623 | 2352361 |
Rash | 44.02 | 31.20 | 54 | 3047 | 59504 | 2295480 |
Syncope | 43.97 | 31.20 | 31 | 3070 | 16844 | 2338140 |
Hypophagia | 43.83 | 31.20 | 19 | 3082 | 3981 | 2351003 |
Intervertebral disc disorder | 43.78 | 31.20 | 12 | 3089 | 629 | 2354355 |
Hepatic cyst | 43.38 | 31.20 | 12 | 3089 | 651 | 2354333 |
Cerebrovascular accident | 43.37 | 31.20 | 33 | 3068 | 20153 | 2334831 |
Lacrimation increased | 43.06 | 31.20 | 17 | 3084 | 2813 | 2352171 |
Blood albumin decreased | 42.82 | 31.20 | 15 | 3086 | 1780 | 2353204 |
Urinary incontinence | 42.79 | 31.20 | 19 | 3082 | 4214 | 2350770 |
Sacroiliitis | 42.76 | 31.20 | 10 | 3091 | 274 | 2354710 |
Plantar fasciitis | 42.64 | 31.20 | 11 | 3090 | 456 | 2354528 |
Knee arthroplasty | 42.46 | 31.20 | 17 | 3084 | 2918 | 2352066 |
Hepatic cirrhosis | 42.46 | 31.20 | 16 | 3085 | 2337 | 2352647 |
Cholangiocarcinoma | 42.40 | 31.20 | 9 | 3092 | 156 | 2354828 |
Endodontic procedure | 42.18 | 31.20 | 11 | 3090 | 476 | 2354508 |
Fractured sacrum | 42.11 | 31.20 | 10 | 3091 | 293 | 2354691 |
Lumbar radiculopathy | 42.08 | 31.20 | 10 | 3091 | 294 | 2354690 |
Scleritis | 41.95 | 31.20 | 10 | 3091 | 298 | 2354686 |
Rhinitis allergic | 41.76 | 31.20 | 12 | 3089 | 748 | 2354236 |
Rheumatoid factor positive | 41.64 | 31.20 | 11 | 3090 | 501 | 2354483 |
Blood bilirubin increased | 41.57 | 31.20 | 20 | 3081 | 5325 | 2349659 |
Adjustment disorder | 41.28 | 31.20 | 9 | 3092 | 178 | 2354806 |
Carotid artery stenosis | 41.15 | 31.20 | 12 | 3089 | 788 | 2354196 |
Monocyte count increased | 41.01 | 31.20 | 11 | 3090 | 531 | 2354453 |
Gastric ulcer haemorrhage | 40.58 | 31.20 | 12 | 3089 | 828 | 2354156 |
Glaucoma | 40.55 | 31.20 | 15 | 3086 | 2080 | 2352904 |
Anti-cyclic citrullinated peptide antibody positive | 40.54 | 31.20 | 9 | 3092 | 194 | 2354790 |
Sinus disorder | 40.44 | 31.20 | 16 | 3085 | 2662 | 2352322 |
Bronchitis | 39.98 | 31.20 | 27 | 3074 | 13687 | 2341297 |
Vitamin B12 decreased | 39.94 | 31.20 | 10 | 3091 | 367 | 2354617 |
Hypoaesthesia oral | 39.93 | 31.20 | 15 | 3086 | 2171 | 2352813 |
Fistula | 39.93 | 31.20 | 14 | 3087 | 1665 | 2353319 |
Pulmonary embolism | 39.81 | 31.20 | 30 | 3071 | 18053 | 2336931 |
Actinic keratosis | 39.76 | 31.20 | 10 | 3091 | 374 | 2354610 |
Cystocele | 39.58 | 31.20 | 9 | 3092 | 217 | 2354767 |
Coronary artery disease | 39.57 | 31.20 | 20 | 3081 | 5919 | 2349065 |
Injury | 39.52 | 31.20 | 20 | 3081 | 5934 | 2349050 |
Oedema | 39.44 | 31.20 | 24 | 3077 | 10179 | 2344805 |
Restless legs syndrome | 39.38 | 31.20 | 15 | 3086 | 2256 | 2352728 |
Haematoma | 39.33 | 31.20 | 19 | 3082 | 5102 | 2349882 |
Mitral valve prolapse | 39.23 | 31.20 | 10 | 3091 | 395 | 2354589 |
Blood pressure increased | 39.22 | 31.20 | 29 | 3072 | 16957 | 2338027 |
Dysstasia | 39.00 | 31.20 | 16 | 3085 | 2923 | 2352061 |
Carotid bruit | 38.65 | 31.20 | 8 | 3093 | 122 | 2354862 |
Bone fissure | 38.64 | 31.20 | 7 | 3094 | 50 | 2354934 |
Osteomyelitis chronic | 38.59 | 31.20 | 8 | 3093 | 123 | 2354861 |
Pneumonia | 38.52 | 31.20 | 46 | 3055 | 49250 | 2305734 |
Diverticulum intestinal | 38.51 | 31.20 | 11 | 3090 | 671 | 2354313 |
Myocardial infarction | 38.47 | 31.20 | 30 | 3071 | 18983 | 2336001 |
Actinomycosis | 38.46 | 31.20 | 9 | 3092 | 247 | 2354737 |
Pollakiuria | 38.42 | 31.20 | 17 | 3084 | 3739 | 2351245 |
Oroantral fistula | 38.17 | 31.20 | 7 | 3094 | 54 | 2354930 |
Monoclonal gammopathy | 38.06 | 31.20 | 8 | 3093 | 132 | 2354852 |
Varicose vein | 37.21 | 31.20 | 11 | 3090 | 758 | 2354226 |
Fibula fracture | 36.96 | 31.20 | 10 | 3091 | 499 | 2354485 |
Skin laceration | 36.95 | 31.20 | 15 | 3086 | 2667 | 2352317 |
Ill-defined disorder | 36.86 | 31.20 | 16 | 3085 | 3362 | 2351622 |
Red blood cell sedimentation rate abnormal | 36.69 | 31.20 | 10 | 3091 | 513 | 2354471 |
Neutrophilia | 36.62 | 31.20 | 10 | 3091 | 517 | 2354467 |
Disease recurrence | 36.53 | 31.20 | 16 | 3085 | 3435 | 2351549 |
Visual impairment | 36.32 | 31.20 | 24 | 3077 | 11731 | 2343253 |
Blood creatine phosphokinase increased | 36.29 | 31.20 | 18 | 3083 | 5118 | 2349866 |
Type 2 diabetes mellitus | 36.28 | 31.20 | 14 | 3087 | 2180 | 2352804 |
Hepatic function abnormal | 36.21 | 31.20 | 19 | 3082 | 6073 | 2348911 |
Edentulous | 36.10 | 31.20 | 7 | 3094 | 75 | 2354909 |
Kyphosis | 35.57 | 31.20 | 9 | 3092 | 345 | 2354639 |
Aortic valve incompetence | 35.56 | 31.20 | 11 | 3090 | 884 | 2354100 |
Post procedural complication | 35.56 | 31.20 | 15 | 3086 | 2939 | 2352045 |
Gastric disorder | 35.42 | 31.20 | 16 | 3085 | 3694 | 2351290 |
Lower respiratory tract infection | 35.36 | 31.20 | 18 | 3083 | 5406 | 2349578 |
Glucose tolerance impaired | 35.22 | 31.20 | 10 | 3091 | 597 | 2354387 |
Joint noise | 34.95 | 31.20 | 10 | 3091 | 614 | 2354370 |
Purulence | 34.84 | 31.20 | 9 | 3092 | 375 | 2354609 |
Hypocalcaemia | 34.72 | 31.20 | 16 | 3085 | 3867 | 2351117 |
Ulcer | 34.70 | 31.20 | 13 | 3088 | 1867 | 2353117 |
Cerebral thrombosis | 34.70 | 31.20 | 9 | 3092 | 381 | 2354603 |
Odynophagia | 34.67 | 31.20 | 11 | 3090 | 961 | 2354023 |
Scar | 34.46 | 31.20 | 13 | 3088 | 1904 | 2353080 |
Dry eye | 34.43 | 31.20 | 16 | 3085 | 3940 | 2351044 |
Skin lesion | 34.17 | 31.20 | 16 | 3085 | 4009 | 2350975 |
Oral candidiasis | 34.14 | 31.20 | 13 | 3088 | 1952 | 2353032 |
Head injury | 34.13 | 31.20 | 16 | 3085 | 4018 | 2350966 |
Lumbar spinal stenosis | 33.85 | 31.20 | 10 | 3091 | 687 | 2354297 |
Vitamin D decreased | 33.72 | 31.20 | 11 | 3090 | 1050 | 2353934 |
Basal cell carcinoma | 33.53 | 31.20 | 14 | 3087 | 2673 | 2352311 |
Upper limb fracture | 33.35 | 31.20 | 14 | 3087 | 2709 | 2352275 |
Lichen planus | 33.31 | 31.20 | 9 | 3092 | 447 | 2354537 |
Night sweats | 33.11 | 31.20 | 15 | 3086 | 3485 | 2351499 |
Bone formation decreased | 32.98 | 31.20 | 6 | 3095 | 44 | 2354940 |
Blood calcium decreased | 32.96 | 31.20 | 13 | 3088 | 2145 | 2352839 |
Visual acuity reduced | 32.85 | 31.20 | 17 | 3084 | 5281 | 2349703 |
Back disorder | 32.82 | 31.20 | 12 | 3089 | 1610 | 2353374 |
Gallbladder disorder | 32.81 | 31.20 | 14 | 3087 | 2820 | 2352164 |
Acute sinusitis | 32.77 | 31.20 | 9 | 3092 | 475 | 2354509 |
Seasonal allergy | 32.76 | 31.20 | 12 | 3089 | 1618 | 2353366 |
Abscess oral | 32.65 | 31.20 | 8 | 3093 | 268 | 2354716 |
Diabetes mellitus | 32.53 | 31.20 | 19 | 3082 | 7476 | 2347508 |
Abdominal pain lower | 32.35 | 31.20 | 14 | 3087 | 2919 | 2352065 |
Appendicectomy | 32.29 | 31.20 | 9 | 3092 | 502 | 2354482 |
Eating disorder | 32.26 | 31.20 | 13 | 3088 | 2268 | 2352716 |
Renal failure | 32.14 | 31.20 | 26 | 3075 | 17323 | 2337661 |
Neuropathy peripheral | 32.10 | 31.20 | 22 | 3079 | 11410 | 2343574 |
Tooth discolouration | 31.99 | 31.20 | 8 | 3093 | 292 | 2354692 |
Viral infection | 31.89 | 31.20 | 16 | 3085 | 4660 | 2350324 |
Gingival abscess | 31.84 | 31.20 | 7 | 3094 | 144 | 2354840 |
Polyarthritis | 31.60 | 31.20 | 10 | 3091 | 866 | 2354118 |
Glossitis | 31.51 | 31.20 | 9 | 3092 | 549 | 2354435 |
Cholelithiasis | 31.39 | 31.20 | 17 | 3084 | 5786 | 2349198 |
Bipolar disorder | 31.38 | 31.20 | 11 | 3090 | 1307 | 2353677 |
Hyperglycaemia | 31.23 | 31.20 | 16 | 3085 | 4869 | 2350115 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Atypical femur fracture | 98.93 | 43.85 | 13 | 316 | 63 | 1746389 |
Femur fracture | 81.77 | 43.85 | 16 | 313 | 1131 | 1745321 |
Osteonecrosis | 66.94 | 43.85 | 17 | 312 | 3945 | 1742507 |
Osteonecrosis of jaw | 65.55 | 43.85 | 17 | 312 | 4286 | 1742166 |
Fall | 60.86 | 43.85 | 25 | 304 | 27189 | 1719263 |
Pathological fracture | 46.76 | 43.85 | 9 | 320 | 577 | 1745875 |
Distal intestinal obstruction syndrome | 45.28 | 43.85 | 6 | 323 | 31 | 1746421 |
Oesophageal rupture | 44.40 | 43.85 | 7 | 322 | 137 | 1746315 |
Source | Code | Description |
---|---|---|
ATC | M05BA07 | MUSCULO-SKELETAL SYSTEM DRUGS FOR TREATMENT OF BONE DISEASES DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION Bisphosphonates |
ATC | M05BB02 | MUSCULO-SKELETAL SYSTEM DRUGS FOR TREATMENT OF BONE DISEASES DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION Bisphosphonates, combinations |
ATC | M05BB04 | MUSCULO-SKELETAL SYSTEM DRUGS FOR TREATMENT OF BONE DISEASES DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION Bisphosphonates, combinations |
ATC | M05BB07 | MUSCULO-SKELETAL SYSTEM DRUGS FOR TREATMENT OF BONE DISEASES DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION Bisphosphonates, combinations |
MeSH PA | D050071 | Bone Density Conservation Agents |
MeSH PA | D002121 | Calcium Channel Blockers |
MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
FDA EPC | N0000175579 | Bisphosphonate |
FDA Chemical/Ingredient | N0000007707 | Diphosphonates |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Osteitis deformans | indication | 2089002 | DOID:5408 |
Osteoporosis | indication | 64859006 | DOID:11476 |
Postmenopausal osteoporosis | indication | 102447009 | |
Glucocorticoid Induced Osteoporosis | indication | ||
Prevention of Glucocorticoid-Induced Osteoporosis | indication | ||
Gastritis | contraindication | 4556007 | DOID:4029 |
Hypocalcemia | contraindication | 5291005 | |
Bone pain | contraindication | 12584003 | |
Constipation | contraindication | 14760008 | DOID:2089 |
Sarcoidosis | contraindication | 31541009 | DOID:11335 |
Dehydration | contraindication | 34095006 | |
Dysphagia | contraindication | 40739000 | |
Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
Joint pain | contraindication | 57676002 | |
Acute nephropathy | contraindication | 58574008 | |
Stricture of esophagus | contraindication | 63305008 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Muscle pain | contraindication | 68962001 | |
Fracture of femur | contraindication | 71620000 | |
Duodenitis | contraindication | 72007001 | DOID:8643 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Kidney stone | contraindication | 95570007 | |
Bed-ridden | contraindication | 160685001 | |
Osteolysis | contraindication | 203522001 | |
Esophageal dysmotility | contraindication | 266434009 | DOID:9192 |
Aseptic necrosis of bone of jaw | contraindication | 441809006 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.35 | acidic |
pKa2 | 6.42 | acidic |
pKa3 | 7.4 | acidic |
pKa4 | 11.47 | acidic |
pKa5 | 12.45 | acidic |
pKa6 | 4.27 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
150MG | ACTONEL | APIL | N020835 | April 22, 2008 | RX | TABLET | ORAL | 7192938 | May 6, 2023 | PREVENTION AND TREATMENT OF OSTEOPOROSIS |
150MG | ACTONEL | APIL | N020835 | April 22, 2008 | RX | TABLET | ORAL | 7718634 | May 6, 2023 | TREATMENT OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN |
35MG | ATELVIA | APIL | N022560 | Oct. 8, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 7645459 | Jan. 9, 2028 | TREATMENT OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN |
35MG | ATELVIA | APIL | N022560 | Oct. 8, 2010 | RX | TABLET, DELAYED RELEASE | ORAL | 7645460 | Jan. 9, 2028 | TREATMENT OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Farnesyl pyrophosphate synthase | Enzyme | INHIBITOR | Ki | 9.44 | CHEMBL | CHEMBL | |||
Farnesyl diphosphate synthase | Enzyme | IC50 | 7.13 | CHEMBL | |||||
Farnesyl diphosphate synthase | Unclassified | IC50 | 7.57 | CHEMBL | |||||
Farnesyl pyrophosphate synthase | Enzyme | Ki | 7.77 | CHEMBL |
ID | Source |
---|---|
D000068296 | MESH_DESCRIPTOR_UI |
C0140610 | UMLSCUI |
D00942 | KEGG_DRUG |
768538005 | SNOMEDCT_US |
768539002 | SNOMEDCT_US |
55685 | RXNORM |
007620 | NDDF |
CHEBI:8869 | CHEBI |
CHEMBL923 | ChEMBL_ID |
DB00884 | DRUGBANK_ID |
CHEMBL1654 | ChEMBL_ID |
F67L43UT5C | UNII |
353228-19-0 | SECONDARY_CAS_RN |
6522 | INN_ID |
RIS | PDB_CHEM_ID |
5245 | PUBCHEM_CID |
3176 | IUPHAR_LIGAND_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
ACTONEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0149-0470 | TABLET, FILM COATED | 30 mg | ORAL | NDA | 18 sections |
ACTONEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0149-0471 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 18 sections |
ACTONEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0149-0472 | TABLET, FILM COATED | 35 mg | ORAL | NDA | 18 sections |
ACTONEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0149-0477 | TABLET, FILM COATED | 75 mg | ORAL | NDA | 18 sections |
ACTONEL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0149-0478 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 18 sections |
Risedronate Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-870 | TABLET, DELAYED RELEASE | 35 mg | ORAL | ANDA | 18 sections |
Risedronate Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33342-107 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 17 sections |
Risedronate Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33342-108 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 17 sections |
Risedronate Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33342-109 | TABLET, FILM COATED | 35 mg | ORAL | ANDA | 17 sections |
Actonel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4386 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 18 sections |
Actonel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4671 | TABLET, FILM COATED | 35 mg | ORAL | NDA | 18 sections |
Actonel | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-6069 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 18 sections |
Risedronate Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-3096 | TABLET, FILM COATED | 75 mg | ORAL | ANDA | 17 sections |
Risedronate Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-3097 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 17 sections |
Risedronate Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-3165 | TABLET, FILM COATED | 35 mg | ORAL | ANDA | 17 sections |
RISEDRONATE SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63304-440 | TABLET, DELAYED RELEASE | 35 mg | ORAL | ANDA | 18 sections |
Risedronate Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65862-517 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 17 sections |
Risedronate Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65862-518 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 17 sections |
Risedronate Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65862-519 | TABLET, FILM COATED | 35 mg | ORAL | ANDA | 17 sections |
Risedronate Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65862-870 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 17 sections |
Risedronate Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68382-075 | TABLET, DELAYED RELEASE | 35 mg | ORAL | ANDA | 19 sections |
Risedronate Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70771-1436 | TABLET, DELAYED RELEASE | 35 mg | ORAL | ANDA | 19 sections |