risedronic acid ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium metabolism regulator, pharmaceutical aid 2387 105462-24-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • risedronate sodium hemi-pentahydrate
  • risedronate sodium monohydrate
  • risedronate sodium anhydrous
  • risedronate sodium hydrate
  • sodium risedronate
  • sodium risedronate hydrate
  • risedronic acid
  • risedronate
  • risedronate sodium
  • actonel
  • risedronic acid monosodium salt
  • risedronic acid monohydrate
A pyridine and diphosphonic acid derivative that acts as a CALCIUM CHANNEL BLOCKER and inhibits BONE RESORPTION.
  • Molecular weight: 283.11
  • Formula: C7H11NO7P2
  • CLOGP: -0.77
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 5
  • TPSA: 148.18
  • ALOGS: -1.43
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O
5 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 87 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.29 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 6.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.76 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 200 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 5 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
March 27, 1998 FDA WARNER CHILCOTT LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Femur fracture 726.93 10.58 602 113676 41154 63333590
Atypical femur fracture 652.28 10.58 274 114004 5098 63369646
Low turnover osteopathy 437.42 10.58 192 114086 3993 63370751
Stress fracture 398.09 10.58 221 114057 7742 63367002
Osteonecrosis of jaw 365.21 10.58 380 113898 34743 63340001
Fracture displacement 284.65 10.58 101 114177 1160 63373584
Osteoarthritis 269.85 10.58 556 113722 94787 63279957
Rheumatoid arthritis 263.18 10.58 1027 113251 252792 63121952
Osteoporosis 248.21 10.58 402 113876 56936 63317808
Death 233.14 10.58 199 114079 374182 63000562
Completed suicide 219.82 10.58 10 114268 145663 63229081
Pathological fracture 218.50 10.58 157 114121 8677 63366067
Toxicity to various agents 216.60 10.58 87 114191 247163 63127581
Foot fracture 202.01 10.58 232 114046 23682 63351062
Osteonecrosis 182.44 10.58 223 114055 24307 63350437
Mobility decreased 182.00 10.58 555 113723 120604 63254140
Bedridden 179.11 10.58 153 114125 10898 63363846
Blood pressure systolic increased 176.80 10.58 311 113967 47086 63327658
Eosinophilic bronchitis 176.76 10.58 58 114220 515 63374229
Bone disorder 175.27 10.58 204 114074 21122 63353622
Nodule 170.92 10.58 200 114078 20826 63353918
Pulmonary fibrosis 165.34 10.58 274 114004 39535 63335209
Jaw disorder 165.18 10.58 109 114169 5240 63369504
Gastrooesophageal reflux disease 164.63 10.58 460 113818 95179 63279565
Osteoporotic fracture 160.45 10.58 94 114184 3652 63371092
Fracture 153.75 10.58 183 114095 19401 63355343
Rheumatoid nodule 152.65 10.58 171 114107 16984 63357760
Osteomyelitis 150.55 10.58 209 114069 25811 63348933
Lower limb fracture 149.90 10.58 201 114077 24020 63350724
Fracture nonunion 149.48 10.58 76 114202 2219 63372525
Foot deformity 139.62 10.58 209 114069 27644 63347100
Osteopenia 139.31 10.58 175 114103 19610 63355134
Systemic lupus erythematosus rash 133.50 10.58 70 114208 2182 63372562
Arthralgia 132.02 10.58 1585 112693 568125 62806619
Neutropenia 129.78 10.58 77 114201 174928 63199816
Atypical fracture 125.05 10.58 46 114232 590 63374154
Asthma 122.98 10.58 505 113773 127056 63247688
Obstructive airways disorder 122.36 10.58 168 114110 20531 63354213
Product dose omission issue 117.01 10.58 150 114128 234163 63140581
Intentional overdose 115.51 10.58 4 114274 74148 63300596
Fracture delayed union 115.01 10.58 65 114213 2357 63372387
Disease progression 114.46 10.58 39 114239 122719 63252025
Tooth disorder 113.17 10.58 191 114087 27966 63346778
COVID-19 107.08 10.58 35 114243 113068 63261676
Loss of personal independence in daily activities 100.82 10.58 394 113884 96896 63277848
Drug abuse 100.26 10.58 8 114270 72510 63302234
Febrile neutropenia 99.90 10.58 44 114234 118405 63256339
Pleural fibrosis 98.20 10.58 67 114211 3405 63371339
Alanine aminotransferase abnormal 97.77 10.58 74 114204 4430 63370314
Presbyacusis 97.35 10.58 62 114216 2803 63371941
Injection site pain 94.96 10.58 58 114220 129742 63245002
Immobile 93.70 10.58 81 114197 5862 63368882
Wheezing 91.74 10.58 378 113900 95217 63279527
Intramedullary rod insertion 90.21 10.58 53 114225 2070 63372674
Malignant neoplasm progression 89.91 10.58 19 114259 82102 63292642
Dental caries 88.38 10.58 103 114175 10676 63364068
Musculoskeletal stiffness 87.74 10.58 601 113677 184017 63190727
Bone sequestrum 85.05 10.58 45 114233 1429 63373315
Anaemia postoperative 84.96 10.58 52 114226 2190 63372554
Maternal exposure during pregnancy 83.38 10.58 169 114109 219893 63154851
Pleural thickening 82.41 10.58 56 114222 2827 63371917
Red blood cell sedimentation rate abnormal 81.91 10.58 136 114142 19646 63355098
Neutrophilia 81.79 10.58 66 114212 4340 63370404
Blood parathyroid hormone decreased 81.01 10.58 94 114184 9697 63365047
Periodontal disease 80.34 10.58 45 114233 1603 63373141
Deafness neurosensory 80.27 10.58 68 114210 4787 63369957
Spinal fracture 80.24 10.58 129 114149 18142 63356602
Acute kidney injury 80.21 10.58 227 114051 263188 63111556
Pelvic fracture 79.89 10.58 109 114169 13239 63361505
Osteogenesis imperfecta 79.22 10.58 33 114245 600 63374144
Cardiac arrest 78.63 10.58 34 114244 92511 63282233
Tooth infection 75.27 10.58 124 114154 17796 63356948
Fibromyalgia 74.81 10.58 315 113963 80105 63294639
Drug interaction 74.61 10.58 191 114087 228940 63145804
Fatigue 74.05 10.58 1140 113138 886888 62487856
Osteosclerosis 73.79 10.58 59 114219 3829 63370915
Peri-implantitis 73.68 10.58 19 114259 62 63374682
Inflammation 73.24 10.58 318 113960 81955 63292789
Red blood cell sedimentation rate increased 73.13 10.58 209 114069 43773 63330971
Somnolence 73.12 10.58 131 114147 178554 63196190
Blood magnesium increased 72.86 10.58 53 114225 2985 63371759
Tooth extraction 72.59 10.58 91 114187 10173 63364571
Pruritus 72.12 10.58 370 113908 361083 63013661
Bursitis 70.54 10.58 185 114093 36856 63337888
Exposure during pregnancy 69.23 10.58 108 114170 155439 63219305
Joint range of motion decreased 69.09 10.58 169 114109 32259 63342485
Pain in extremity 66.18 10.58 898 113380 330588 63044156
Blood pressure diastolic decreased 66.03 10.58 134 114144 22572 63352172
Salpingo-oophorectomy unilateral 65.74 10.58 32 114246 849 63373895
Sinusitis fungal 65.66 10.58 41 114237 1790 63372954
Polyp 64.97 10.58 69 114209 6452 63368292
Thrombocytopenia 64.41 10.58 108 114170 151049 63223695
Seizure 64.02 10.58 87 114191 132547 63242197
Impaired healing 63.88 10.58 358 113920 102184 63272560
Panniculitis 63.69 10.58 90 114188 11295 63363449
Ankle arthroplasty 63.51 10.58 40 114238 1773 63372971
Arthritis 63.36 10.58 391 113887 115530 63259214
Comminuted fracture 62.88 10.58 27 114251 531 63374213
Resorption bone increased 62.69 10.58 35 114243 1239 63373505
Bone cyst 62.58 10.58 43 114235 2211 63372533
Ulna fracture 62.47 10.58 34 114244 1144 63373600
Periodontitis 62.43 10.58 50 114228 3253 63371491
Blood pressure diastolic abnormal 61.58 10.58 101 114177 14441 63360303
Basal cell carcinoma 60.83 10.58 147 114131 27844 63346900
Foot operation 60.79 10.58 70 114208 7161 63367583
Oedema 60.26 10.58 340 113938 97282 63277462
Sepsis 60.21 10.58 115 114163 153008 63221736
Fall 59.81 10.58 1015 113263 391319 62983425
Respiratory symptom 59.74 10.58 49 114229 3298 63371446
Injection site erythema 59.66 10.58 38 114240 83136 63291608
Granuloma skin 58.39 10.58 74 114204 8363 63366381
Adjustment disorder with depressed mood 57.58 10.58 81 114197 10123 63364621
Nerve injury 56.20 10.58 79 114199 9867 63364877
Wrong technique in product usage process 56.05 10.58 21 114257 62319 63312425
Diverticulum 55.88 10.58 87 114191 11904 63362840
Suicide attempt 55.65 10.58 20 114258 60898 63313846
Muscle fatigue 55.37 10.58 42 114236 2522 63372222
Arthropathy 54.42 10.58 654 113624 234138 63140606
Rash 53.65 10.58 700 113578 560171 62814573
No adverse event 53.43 10.58 6 114272 41399 63333345
Therapeutic product effect variable 53.20 10.58 31 114247 1192 63373552
Dental fistula 53.09 10.58 25 114253 615 63374129
Dehydration 53.01 10.58 149 114129 173205 63201539
Skin necrosis 52.60 10.58 92 114186 13858 63360886
Type 2 diabetes mellitus 52.42 10.58 241 114037 63627 63311117
Gingivitis 52.22 10.58 70 114208 8359 63366385
Device failure 51.90 10.58 59 114219 5952 63368792
Drug hypersensitivity 51.47 10.58 815 113463 309872 63064872
Dyspnoea 50.62 10.58 862 113416 660451 62714293
Sputum increased 50.30 10.58 39 114239 2420 63372324
Blood pressure systolic abnormal 50.10 10.58 88 114190 13298 63361446
Coma 49.56 10.58 27 114251 64337 63310407
Deep vein thrombosis postoperative 49.55 10.58 80 114198 11289 63363455
Red blood cell sedimentation rate 49.50 10.58 52 114226 4802 63369942
Epigastric discomfort 49.37 10.58 61 114217 6719 63368025
Open reduction of fracture 49.35 10.58 29 114249 1133 63373611
Ulcer 49.31 10.58 130 114148 25977 63348767
Tendonitis 49.20 10.58 109 114169 19506 63355238
Sciatica 48.47 10.58 154 114124 34170 63340574
Hypercalcaemia 48.46 10.58 136 114142 28186 63346558
Suicidal ideation 48.34 10.58 26 114252 62395 63312349
Fear of injection 48.26 10.58 62 114216 7102 63367642
Tooth fracture 48.18 10.58 78 114200 11032 63363712
Eosinophil count increased 47.77 10.58 77 114201 10851 63363893
Groin pain 47.51 10.58 74 114204 10129 63364615
Blood pressure fluctuation 47.48 10.58 187 114091 46130 63328614
Carpal tunnel syndrome 47.04 10.58 111 114167 20706 63354038
Bone density decreased 47.04 10.58 90 114188 14522 63360222
Rheumatoid factor positive 46.93 10.58 286 113992 84120 63290624
Therapy interrupted 46.52 10.58 3 114275 32452 63342292
Spinal osteoarthritis 46.44 10.58 95 114183 16091 63358653
Abortion spontaneous 45.73 10.58 14 114264 47181 63327563
Product use in unapproved indication 45.62 10.58 167 114111 178913 63195831
Purulent discharge 45.48 10.58 49 114229 4657 63370087
Total lung capacity decreased 45.47 10.58 35 114243 2148 63372596
Infection 45.33 10.58 620 113658 228553 63146191
Prescribed overdose 45.31 10.58 150 114128 34003 63340741
Bone formation decreased 44.31 10.58 13 114265 76 63374668
Rheumatic fever 44.15 10.58 174 114104 42937 63331807
Osteonecrosis of external auditory canal 43.84 10.58 14 114264 113 63374631
Embolism venous 43.78 10.58 40 114238 3114 63371630
Tachycardia 43.65 10.58 92 114186 118064 63256680
Spinal compression fracture 43.57 10.58 86 114192 14197 63360547
Exostosis 43.39 10.58 98 114180 17764 63356980
Oral cavity fistula 43.09 10.58 22 114256 648 63374096
Autoimmune disorder 42.58 10.58 95 114183 17082 63357662
Nasal oedema 42.17 10.58 29 114249 1493 63373251
Joint destruction 41.95 10.58 54 114224 6198 63368546
Jaw fracture 41.73 10.58 36 114242 2598 63372146
Exostosis of jaw 41.59 10.58 27 114251 1262 63373482
Alopecia 41.40 10.58 398 113880 337138 63037606
Overdose 41.35 10.58 91 114187 114987 63259757
Injection site swelling 41.16 10.58 17 114261 47555 63327189
White blood cell count decreased 40.74 10.58 122 114156 138982 63235762
Bone graft 40.62 10.58 24 114254 947 63373797
Drug tolerance 40.46 10.58 56 114222 6893 63367851
Synovitis 40.41 10.58 514 113764 186404 63188340
Drug intolerance 40.10 10.58 779 113499 307882 63066862
Gingival disorder 39.84 10.58 40 114238 3502 63371242
Swollen joint count increased 39.77 10.58 149 114129 35905 63338839
Skin ulcer 39.54 10.58 168 114110 42877 63331867
Hypertension 39.06 10.58 713 113565 278590 63096154
Anaphylactic reaction 38.79 10.58 37 114241 66063 63308681
Pyrexia 38.65 10.58 605 113673 469873 62904871
Periprosthetic fracture 38.11 10.58 18 114260 446 63374298
Accidental exposure to product 37.94 10.58 3 114275 27402 63347342
C-reactive protein abnormal 37.87 10.58 174 114104 45922 63328822
Multiple sclerosis relapse 37.82 10.58 20 114258 48458 63326286
Bone fragmentation 37.55 10.58 21 114257 746 63373998
Diastolic dysfunction 37.45 10.58 52 114226 6419 63368325
Feeling abnormal 37.38 10.58 139 114139 148253 63226491
Tenosynovitis 37.28 10.58 79 114199 13716 63361028
Rotator cuff syndrome 37.27 10.58 78 114200 13424 63361320
Hiatus hernia 37.25 10.58 104 114174 21490 63353254
Mucosal inflammation 37.14 10.58 19 114259 46909 63327835
Intentional product misuse 37.05 10.58 33 114245 60884 63313860
Respiratory failure 37.04 10.58 80 114198 101778 63272966
Walking aid user 36.97 10.58 68 114210 10649 63364095
Neoplasm progression 36.78 10.58 10 114268 36418 63338326
Bone loss 36.71 10.58 36 114242 3063 63371681
Dislocation of vertebra 36.60 10.58 60 114218 8575 63366169
Deformity 36.43 10.58 71 114207 11613 63363131
Anaemia 36.39 10.58 345 113933 293085 63081659
Bunion operation 36.18 10.58 25 114253 1297 63373447
Depressed level of consciousness 36.14 10.58 35 114243 62043 63312701
Lactic acidosis 35.95 10.58 12 114266 38275 63336469
Oral herpes 35.92 10.58 116 114162 25958 63348786
Anal abscess 35.88 10.58 43 114235 4589 63370155
Polyarthritis 35.79 10.58 65 114213 10081 63364663
Loose tooth 35.76 10.58 37 114241 3357 63371387
Therapy cessation 35.56 10.58 6 114272 30451 63344293
Fistula discharge 35.52 10.58 23 114255 1070 63373674
Lip dry 35.51 10.58 83 114195 15387 63359357
Bradycardia 35.35 10.58 48 114230 73179 63301565
Platelet count decreased 35.34 10.58 100 114178 116022 63258722
Limb asymmetry 35.31 10.58 21 114257 839 63373905
Bone erosion 35.28 10.58 90 114188 17627 63357117
Drug ineffective for unapproved indication 35.06 10.58 9 114269 34054 63340690
Sedation 35.01 10.58 13 114265 38796 63335948
Cyst 34.97 10.58 78 114200 14021 63360723
Constipation 34.94 10.58 249 114029 224694 63150050
Treatment failure 34.77 10.58 527 113751 198516 63176228
Injection site pruritus 34.63 10.58 19 114259 45097 63329647
Peripheral venous disease 34.40 10.58 82 114196 15395 63359349
Lung opacity 34.21 10.58 35 114243 3133 63371611
Nasal polyps 34.17 10.58 48 114230 5991 63368753
Hunger 33.83 10.58 45 114233 5334 63369410
Neutrophil count decreased 33.77 10.58 31 114247 56375 63318369
Dental necrosis 33.65 10.58 12 114266 140 63374604
Adrenal insufficiency 33.62 10.58 89 114189 17826 63356918
Headache 33.51 10.58 876 113402 632365 62742379
Oral infection 33.48 10.58 43 114235 4925 63369819
Premature delivery 33.15 10.58 7 114271 30274 63344470
Acute phase reaction 32.90 10.58 14 114264 269 63374475
Drug eruption 32.83 10.58 120 114158 28574 63346170
Enthesopathy 32.72 10.58 57 114221 8557 63366187
Wheelchair user 32.49 10.58 48 114230 6271 63368473
Blood potassium increased 32.39 10.58 89 114189 18220 63356524
Meniscus injury 32.29 10.58 51 114227 7063 63367681
Agitation 32.18 10.58 36 114242 59721 63315023
Bronchiectasis 32.15 10.58 82 114196 16060 63358684
Bronchopulmonary aspergillosis allergic 32.05 10.58 29 114249 2229 63372515
Wound infection 32.02 10.58 98 114180 21312 63353432
Illness 31.77 10.58 25 114253 49034 63325710
Diarrhoea 31.72 10.58 1014 113264 714352 62660392
Tongue disorder 31.43 10.58 63 114215 10517 63364227
Blood pressure diastolic increased 31.42 10.58 61 114217 9949 63364795
Leukopenia 31.29 10.58 57 114221 77233 63297511
Gingival ulceration 31.29 10.58 20 114258 910 63373834
Emphysema 31.14 10.58 64 114214 10874 63363870
Nausea 31.12 10.58 1241 113037 853230 62521514
Contraindicated product administered 30.90 10.58 557 113721 217091 63157653
Malocclusion 30.76 10.58 10 114268 86 63374658
Blood cholesterol increased 30.26 10.58 280 113998 93752 63280992
Facet joint syndrome 29.94 10.58 67 114211 12071 63362673
Respiratory tract congestion 29.89 10.58 85 114193 17747 63356997
Metaphyseal corner fracture 29.76 10.58 8 114270 32 63374712
Systemic lupus erythematosus 29.72 10.58 237 114041 208681 63166063
Syncope 29.53 10.58 110 114168 117275 63257469
Respiratory arrest 29.34 10.58 11 114267 32634 63342110
Confusional state 29.26 10.58 278 114000 236102 63138642
Arteriovenous fistula occlusion 28.98 10.58 14 114264 365 63374379
Vaginal haemorrhage 28.80 10.58 7 114271 27480 63347264
Full blood count decreased 28.52 10.58 6 114272 26018 63348726
Fracture malunion 28.46 10.58 11 114267 163 63374581
Tremor 28.25 10.58 132 114146 132107 63242637
Blue toe syndrome 28.04 10.58 14 114264 393 63374351
Drug resistance 27.95 10.58 4 114274 22929 63351815
Drug reaction with eosinophilia and systemic symptoms 27.84 10.58 13 114265 33823 63340921
Electrocardiogram QT prolonged 27.76 10.58 40 114238 59490 63315254
Injection site bruising 27.60 10.58 21 114257 41889 63332855
Pulmonary arterial hypertension 27.37 10.58 4 114274 22573 63352171
Interstitial lung disease 27.29 10.58 198 114080 61710 63313034
Joint injury 26.83 10.58 115 114163 29457 63345287
Femoral neck fracture 26.82 10.58 52 114226 8471 63366273
Obesity 26.81 10.58 116 114162 29836 63344908
C-reactive protein 26.43 10.58 38 114240 4844 63369900
Breath sounds abnormal 26.43 10.58 60 114218 10913 63363831
Joint swelling 26.32 10.58 774 113504 326892 63047852
Drug tolerance decreased 26.15 10.58 80 114198 17393 63357351
Abscess jaw 26.02 10.58 21 114257 1381 63373363
Fluid retention 26.01 10.58 42 114236 59644 63315100
Hyperhidrosis 25.87 10.58 103 114175 107733 63267011
Pain in jaw 25.84 10.58 150 114128 43346 63331398
Polymyalgia rheumatica 25.84 10.58 33 114245 3758 63370986
Tooth abscess 25.72 10.58 72 114206 14897 63359847
Multiple organ dysfunction syndrome 25.62 10.58 39 114239 56713 63318031
Pancytopenia 25.60 10.58 89 114189 96844 63277900
Ill-defined disorder 25.58 10.58 242 114036 81513 63293231
Therapeutic response decreased 25.54 10.58 194 114084 61331 63313413
Radius fracture 25.34 10.58 32 114246 3603 63371141
Tibia fracture 25.05 10.58 38 114240 5082 63369662
Myelosuppression 24.90 10.58 6 114272 23697 63351047
Hypervolaemia 24.83 10.58 10 114268 28403 63346341
Spinal disorder 24.81 10.58 55 114223 9847 63364897
Drug withdrawal syndrome 24.71 10.58 9 114269 27185 63347559
Hyperkalaemia 24.71 10.58 37 114241 54166 63320578
Bursitis infective 24.68 10.58 20 114258 1323 63373421
Acute respiratory distress syndrome 24.64 10.58 6 114272 23528 63351216
Inappropriate schedule of product administration 24.50 10.58 100 114178 103865 63270879
Granuloma 24.37 10.58 40 114238 5721 63369023
Toothache 24.29 10.58 83 114195 19116 63355628
Tooth loss 24.28 10.58 44 114234 6812 63367932
Gait inability 24.28 10.58 171 114107 52788 63321956
Renal failure 24.22 10.58 119 114159 117533 63257211
Temporomandibular joint syndrome 23.88 10.58 33 114245 4056 63370688
Palmar-plantar erythrodysaesthesia syndrome 23.84 10.58 6 114272 23009 63351735
Liver disorder 23.83 10.58 172 114106 53515 63321229
Mass excision 23.80 10.58 12 114266 344 63374400
Bone pain 23.65 10.58 174 114104 54467 63320277
Serotonin syndrome 23.63 10.58 11 114267 28671 63346073
Calcium deficiency 23.51 10.58 18 114260 1096 63373648
Abnormal behaviour 23.36 10.58 5 114273 21421 63353323
Heart rate decreased 23.21 10.58 151 114127 45409 63329335
Withdrawal syndrome 23.21 10.58 4 114274 19993 63354751
Breast cancer stage III 23.05 10.58 55 114223 10331 63364413
Hysterectomy 22.94 10.58 52 114226 9447 63365297
Nail bed inflammation 22.71 10.58 12 114266 380 63374364
Visual impairment 22.66 10.58 77 114201 84369 63290375
Thoracic vertebral fracture 22.35 10.58 34 114244 4558 63370186
Product quality issue 22.33 10.58 19 114259 35846 63338898
Atrophy 22.18 10.58 21 114257 1711 63373033
Vitamin D deficiency 22.11 10.58 65 114213 13827 63360917
Muscle spasticity 21.97 10.58 6 114272 21788 63352956
Sputum discoloured 21.86 10.58 72 114206 16275 63358469
Peripheral vascular disorder 21.72 10.58 39 114239 5996 63368748
Hepatitis 21.59 10.58 134 114144 39654 63335090
Dry mouth 21.22 10.58 224 114054 77639 63297105
Glossodynia 21.02 10.58 213 114065 178663 63196081
Rheumatoid lung 20.91 10.58 30 114248 3818 63370926
Hallucination 20.81 10.58 42 114236 54775 63319969
Muscle strain 20.77 10.58 46 114232 8228 63366516
Sopor 20.72 10.58 7 114271 22157 63352587
Pemphigus 20.68 10.58 221 114057 183505 63191239
Neurotoxicity 20.62 10.58 3 114275 16987 63357757
Flushing 20.46 10.58 68 114210 75019 63299725
Metabolic acidosis 20.31 10.58 31 114247 45038 63329706
Bacterial infection 20.20 10.58 79 114199 19420 63355324
Hypersomnia 20.12 10.58 4 114274 18051 63356693
Vision blurred 20.08 10.58 91 114187 91833 63282911
Hyperlipidaemia 20.04 10.58 79 114199 19492 63355252
Encephalopathy 20 10.58 24 114254 38596 63336148
Spondylolisthesis 19.85 10.58 28 114250 3508 63371236
Weight bearing difficulty 19.83 10.58 24 114254 2588 63372156
Rales 19.82 10.58 59 114219 12638 63362106
Device malfunction 19.81 10.58 4 114274 17853 63356891
Mental disorder 19.77 10.58 11 114267 25908 63348836
Neutropenic sepsis 19.73 10.58 3 114275 16435 63358309
Patellofemoral pain syndrome 19.66 10.58 13 114265 627 63374117
Lethargy 19.53 10.58 45 114233 55962 63318782
Fractured sacrum 19.50 10.58 21 114257 1995 63372749
Hyperaesthesia teeth 19.48 10.58 20 114258 1798 63372946
Myopathy toxic 19.34 10.58 12 114266 518 63374226
Iron deficiency anaemia 19.16 10.58 79 114199 19890 63354854
Gingival swelling 19.13 10.58 31 114247 4387 63370357
Blood creatine phosphokinase MB 19.05 10.58 4 114274 3 63374741
C-reactive protein increased 19.01 10.58 257 114021 94450 63280294
Lumbar vertebral fracture 18.96 10.58 36 114242 5774 63368970
Monoclonal gammopathy 18.96 10.58 13 114265 666 63374078
Off label use 18.94 10.58 1007 113271 673455 62701289
Product prescribing error 18.86 10.58 12 114266 26277 63348467
Hyperparathyroidism 18.85 10.58 24 114254 2725 63372019
Mastication disorder 18.74 10.58 21 114257 2085 63372659
Immunodeficiency 18.56 10.58 79 114199 20175 63354569
Rheumatoid factor 18.49 10.58 10 114268 332 63374412
Liver injury 18.36 10.58 178 114100 60342 63314402
Coagulopathy 18.33 10.58 7 114271 20537 63354207
Sleep disorder 18.33 10.58 226 114052 81340 63293404
Pseudarthrosis 18.30 10.58 11 114267 448 63374296
Irritability 18.29 10.58 18 114260 31676 63343068
Blood pressure increased 18.05 10.58 400 113878 161662 63213082
Endometrial disorder 17.97 10.58 13 114265 726 63374018
Respiratory tract inflammation 17.90 10.58 12 114266 592 63374152
Bone density abnormal 17.74 10.58 26 114252 3372 63371372
Fracture pain 17.73 10.58 13 114265 741 63374003
Dysarthria 17.73 10.58 31 114247 42680 63332064
Bone marrow oedema 17.62 10.58 16 114262 1236 63373508
Hepatic failure 17.59 10.58 23 114255 35633 63339111
Hospitalisation 17.54 10.58 86 114192 84995 63289749
Unresponsive to stimuli 17.53 10.58 21 114257 33795 63340949
Granulomatosis with polyangiitis 17.50 10.58 21 114257 2244 63372500
Tricuspid valve incompetence 17.45 10.58 62 114216 14559 63360185
Cerumen impaction 17.43 10.58 15 114263 1079 63373665
Wrist fracture 17.42 10.58 59 114219 13528 63361216
Metastases to bone 17.41 10.58 8 114270 21011 63353733
Musculoskeletal toxicity 17.39 10.58 6 114272 63 63374681
Lung disorder 17.38 10.58 180 114098 62081 63312663
Barrett's oesophagus 17.36 10.58 12 114266 623 63374121
Palmoplantar pustulosis 17.18 10.58 11 114267 502 63374242
Osteitis 17.02 10.58 25 114253 3249 63371495
Gait disturbance 17.02 10.58 441 113837 182737 63192007
Skin lesion 17.00 10.58 104 114174 30617 63344127
Mite allergy 16.94 10.58 12 114266 648 63374096
Colitis 16.91 10.58 39 114239 48489 63326255
Female genital tract fistula 16.74 10.58 40 114238 7519 63367225
Type V hyperlipidaemia 16.66 10.58 11 114267 529 63374215
Cardio-respiratory arrest 16.55 10.58 54 114224 59905 63314839
Intervertebral disc degeneration 16.51 10.58 64 114214 15668 63359076
Bone hypertrophy 16.49 10.58 10 114268 414 63374330
Blood pressure inadequately controlled 16.44 10.58 31 114247 4947 63369797
Humerus fracture 16.43 10.58 44 114234 8872 63365872
Purulence 16.30 10.58 17 114261 1557 63373187
Conjunctival oedema 16.28 10.58 12 114266 690 63374054
Acute respiratory failure 16.24 10.58 23 114255 34462 63340282
Cardiac failure 16.21 10.58 94 114184 89048 63285696
Mental status changes 16.21 10.58 29 114249 39570 63335174
Hepatotoxicity 16.20 10.58 26 114252 37015 63337729
Cardiogenic shock 16.18 10.58 6 114272 17926 63356818
Vomiting 16.17 10.58 833 113445 558784 62815960
Blood calcium increased 16.09 10.58 45 114233 9305 63365439
Thrombosis 16.07 10.58 61 114217 64694 63310050
Nocturnal dyspnoea 15.98 10.58 15 114263 1209 63373535
Episcleral hyperaemia 15.97 10.58 3 114275 0 63374744
Osteomyelitis chronic 15.96 10.58 10 114268 439 63374305
Stomatitis 15.96 10.58 166 114112 138559 63236185
Ventricular tachycardia 15.94 10.58 8 114270 19971 63354773
Urethral caruncle 15.90 10.58 6 114272 83 63374661
Spinal stenosis 15.89 10.58 61 114217 14864 63359880
Adverse drug reaction 15.86 10.58 216 114062 79498 63295246
Pulmonary embolism 15.83 10.58 134 114144 116550 63258194
Stevens-Johnson syndrome 15.80 10.58 13 114265 24937 63349807
Intervertebral disc disorder 15.80 10.58 30 114248 4813 63369931
Skeletal injury 15.71 10.58 15 114263 1235 63373509
Injection site warmth 15.66 10.58 4 114274 15191 63359553
Therapy non-responder 15.65 10.58 207 114071 75694 63299050
Injury 15.63 10.58 201 114077 73046 63301698
Injection site mass 15.61 10.58 7 114271 18649 63356095
Disturbance in attention 15.60 10.58 28 114250 38161 63336583
Skin exfoliation 15.54 10.58 34 114244 43068 63331676
Dystonia 15.53 10.58 3 114275 13816 63360928
Muscle twitching 15.51 10.58 8 114270 19660 63355084
Gingival recession 15.47 10.58 16 114262 1451 63373293
Urine odour abnormal 15.46 10.58 35 114243 6354 63368390
Psoriatic arthropathy 15.45 10.58 241 114037 91279 63283465
Urosepsis 15.42 10.58 7 114271 18517 63356227
Respiratory depression 15.37 10.58 3 114275 13712 63361032
Grip strength decreased 15.34 10.58 80 114198 22207 63352537
Posterior reversible encephalopathy syndrome 15.33 10.58 6 114272 17339 63357405
Tachypnoea 15.27 10.58 6 114272 17296 63357448
Incorrect dose administered 15.20 10.58 56 114222 59912 63314832
Bone fissure 15.18 10.58 7 114271 164 63374580
Influenza 15.14 10.58 124 114154 108598 63266146
Acute hepatic failure 15.14 10.58 7 114271 18320 63356424
General physical health deterioration 15.13 10.58 472 113806 200930 63173814
Psoriasis 15.12 10.58 93 114185 86864 63287880
Edentulous 15.12 10.58 8 114270 254 63374490
Toxic epidermal necrolysis 15.07 10.58 14 114264 25320 63349424
Mood swings 15.03 10.58 7 114271 18241 63356503
Traumatic ulcer 14.99 10.58 5 114273 47 63374697
Live birth 14.97 10.58 88 114190 25542 63349202
X-ray abnormal 14.92 10.58 40 114238 8070 63366674
Full blood count abnormal 14.88 10.58 103 114175 31614 63343130
Caesarean section 14.87 10.58 6 114272 17026 63357718
Limb discomfort 14.84 10.58 98 114180 29618 63345126
Eosinophil count decreased 14.83 10.58 19 114259 2171 63372573
Uterine disorder 14.78 10.58 23 114255 3146 63371598
Large intestine polyp 14.78 10.58 40 114238 8117 63366627
Exposed bone in jaw 14.73 10.58 22 114256 2903 63371841
Blood creatinine increased 14.71 10.58 231 114047 87613 63287131
Eczema 14.64 10.58 104 114174 32187 63342557
Restlessness 14.52 10.58 19 114259 29434 63345310
Pulmonary congestion 14.49 10.58 66 114212 17352 63357392
Kidney infection 14.47 10.58 81 114197 23095 63351649
Cystocele 14.39 10.58 14 114264 1180 63373564
Rash maculo-papular 14.32 10.58 22 114256 31874 63342870
Bruxism 14.28 10.58 24 114254 3501 63371243
Mouth ulceration 14.25 10.58 105 114173 32879 63341865
Nodal osteoarthritis 14.17 10.58 12 114266 844 63373900
Mesenteric panniculitis 14.16 10.58 6 114272 114 63374630
Urine calcium/creatinine ratio increased 14.16 10.58 6 114272 114 63374630
Blood cholinesterase increased 14.16 10.58 4 114274 20 63374724
Dental plaque 14.11 10.58 6 114272 115 63374629
Chronic sinusitis 14.10 10.58 53 114225 12790 63361954
Emotional distress 14.09 10.58 23 114255 32526 63342218
Angioedema 14.08 10.58 42 114236 47923 63326821
Intentional product use issue 14.02 10.58 315 113963 127577 63247167
Drug dependence 14.02 10.58 14 114264 24469 63350275
Actinomycosis 13.96 10.58 13 114265 1037 63373707
Status epilepticus 13.91 10.58 5 114273 15228 63359516
Caecum operation 13.89 10.58 3 114275 3 63374741
Dry skin 13.85 10.58 54 114224 56833 63317911
Diabetic ketoacidosis 13.85 10.58 10 114268 20495 63354249
Adverse event 13.83 10.58 184 114094 67375 63307369
Vitamin B12 decreased 13.81 10.58 24 114254 3596 63371148
Unevaluable event 13.68 10.58 47 114231 51339 63323405
Medical device removal 13.59 10.58 14 114264 1263 63373481
Necrotising ulcerative gingivostomatitis 13.55 10.58 4 114274 24 63374720
Multiple allergies 13.54 10.58 4 114274 13798 63360946
Cardiac failure congestive 13.53 10.58 104 114174 92329 63282415
Impaired quality of life 13.51 10.58 4 114274 13779 63360965
Coordination abnormal 13.50 10.58 4 114274 13769 63360975
Dyskinesia 13.49 10.58 23 114255 31979 63342765
Lumbar spinal stenosis 13.48 10.58 28 114250 4794 63369950
Peripheral sensorimotor neuropathy 13.40 10.58 15 114263 1488 63373256
Jaw cyst 13.40 10.58 6 114272 131 63374613
Adrenal suppression 13.38 10.58 12 114266 912 63373832
Hypotension 13.34 10.58 381 113897 272223 63102521
Oesophagitis 13.34 10.58 58 114220 14950 63359794
Scapula fracture 13.27 10.58 9 114269 453 63374291
Cataract operation 13.08 10.58 30 114248 5492 63369252
Generalised tonic-clonic seizure 13.04 10.58 20 114258 28996 63345748
Enchondromatosis 13.00 10.58 5 114273 73 63374671
Polyneuropathy 12.97 10.58 5 114273 14584 63360160
Injection site rash 12.93 10.58 9 114269 18800 63355944
Aggression 12.82 10.58 14 114264 23484 63351260
Neuroleptic malignant syndrome 12.77 10.58 3 114275 12053 63362691
Ilium fracture 12.76 10.58 6 114272 147 63374597
Kyphoscoliosis 12.75 10.58 9 114269 483 63374261
Osteochondrosis 12.72 10.58 14 114264 1363 63373381
Vaginal polyp 12.68 10.58 3 114275 6 63374738
Giant cell arteritis 12.65 10.58 18 114260 2273 63372471
Accidental overdose 12.59 10.58 14 114264 23295 63351449
Intensive care unit acquired weakness 12.56 10.58 11 114267 810 63373934
Oedema peripheral 12.41 10.58 437 113841 189074 63185670
Inner ear inflammation 12.37 10.58 3 114275 7 63374737
Lymphopenia 12.30 10.58 9 114269 18318 63356426
Oxygen saturation decreased 12.30 10.58 226 114052 88359 63286385
Oral discharge 12.26 10.58 6 114272 161 63374583
Psychotic disorder 12.26 10.58 17 114261 25695 63349049
Right ventricular failure 12.12 10.58 8 114270 17180 63357564
Atopy 12.09 10.58 7 114271 266 63374478
Vascular skin disorder 12.08 10.58 3 114275 8 63374736
Gingivectomy 12.08 10.58 3 114275 8 63374736
Device issue 12.08 10.58 15 114263 23766 63350978
International normalised ratio increased 12.00 10.58 43 114235 46382 63328362
Rubella 11.93 10.58 6 114272 171 63374573
Postoperative wound infection 11.92 10.58 45 114233 10880 63363864
Metastases to liver 11.91 10.58 15 114263 23624 63351120
Eye injury 11.89 10.58 20 114258 2919 63371825
Urinary tract disorder 11.88 10.58 20 114258 2921 63371823
Chronic kidney disease 11.77 10.58 42 114236 45356 63329388
Scoliosis 11.70 10.58 36 114242 7852 63366892
Haematochezia 11.69 10.58 53 114225 53491 63321253
Lumbar radiculopathy 11.66 10.58 16 114262 1953 63372791
Infrequent bowel movements 11.62 10.58 13 114265 1289 63373455
Rib fracture 11.57 10.58 75 114203 22522 63352222
Epileptic encephalopathy 11.54 10.58 7 114271 290 63374454
Carotid bruit 11.50 10.58 10 114268 729 63374015
Bone marrow failure 11.50 10.58 22 114256 29268 63345476
Atrophic vulvovaginitis 11.44 10.58 15 114263 1753 63372991
Osteomalacia 11.43 10.58 10 114268 735 63374009
Hypertonic bladder 11.42 10.58 22 114256 3566 63371178
Pulpitis dental 11.40 10.58 11 114267 917 63373827
Pleurisy 11.39 10.58 37 114241 8303 63366441
Affect lability 11.37 10.58 3 114275 11148 63363596
Upper respiratory tract inflammation 11.33 10.58 18 114260 2505 63372239
Nasal herpes 11.28 10.58 8 114270 433 63374311
Feeling jittery 11.26 10.58 5 114273 13398 63361346
Hip fracture 11.16 10.58 91 114187 29383 63345361
Bone resorption test abnormal 11.16 10.58 3 114275 12 63374732
Pallor 11.11 10.58 24 114254 30544 63344200
Foetal death 11.11 10.58 3 114275 10977 63363767
Epistaxis 11.03 10.58 81 114197 72644 63302100
Pancreatitis acute 11.02 10.58 20 114258 27146 63347598
Rheumatoid factor negative 11.02 10.58 9 114269 602 63374142
Nasal congestion 11.02 10.58 71 114207 65589 63309155
Parophthalmia 11.00 10.58 7 114271 316 63374428
Enterococcus test positive 10.96 10.58 12 114266 1161 63373583
Hypoaesthesia 10.95 10.58 388 113890 168005 63206739
Iliotibial band syndrome 10.91 10.58 6 114272 206 63374538
Actinic keratosis 10.91 10.58 18 114260 2586 63372158
Joint effusion 10.90 10.58 60 114218 17000 63357744
Immunoglobulins increased 10.90 10.58 8 114270 457 63374287
Myalgia 10.89 10.58 343 113935 146186 63228558
COVID-19 pneumonia 10.88 10.58 6 114272 14203 63360541
Cytomegalovirus infection 10.87 10.58 13 114265 20939 63353805
Alveolar bone resorption 10.83 10.58 4 114274 52 63374692
Respiratory rate increased 10.82 10.58 51 114227 13597 63361147
Ataxia 10.81 10.58 7 114271 15188 63359556
Vertebral foraminal stenosis 10.80 10.58 11 114267 979 63373765
Fibrocystic breast disease 10.80 10.58 12 114266 1180 63373564
Electrophoresis protein abnormal 10.79 10.58 3 114275 14 63374730
Blood thyroid stimulating hormone 10.79 10.58 3 114275 14 63374730
Body temperature decreased 10.75 10.58 68 114210 20251 63354493
Polychondritis 10.74 10.58 8 114270 467 63374277
Tubulointerstitial nephritis 10.70 10.58 12 114266 19891 63354853
Bite 10.66 10.58 8 114270 473 63374271
Myocardial infarction 10.62 10.58 245 114033 99648 63275096
Therapy partial responder 10.62 10.58 3 114275 10655 63364089
Enterovirus infection 10.58 10.58 11 114267 1003 63373741

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood pressure systolic increased 111.56 13.68 90 16411 22862 34917568
Rheumatoid arthritis 94.65 13.68 103 16398 38135 34902295
Atypical femur fracture 81.90 13.68 21 16480 313 34940117
Sleep disorder due to general medical condition, insomnia type 71.73 13.68 26 16475 1290 34939140
Blood pressure increased 65.81 13.68 135 16366 87967 34852463
Heart rate decreased 62.50 13.68 76 16425 31669 34908761
Pemphigus 59.34 13.68 24 16477 1607 34938823
Impaired work ability 58.50 13.68 38 16463 6892 34933538
Body temperature decreased 54.77 13.68 47 16454 12987 34927443
Toxicity to various agents 50.34 13.68 16 16485 200346 34740084
Cystitis escherichia 47.04 13.68 12 16489 175 34940255
Lacrimal disorder 44.45 13.68 13 16488 323 34940107
Femur fracture 44.06 13.68 34 16467 8090 34932340
Arthralgia 43.52 13.68 177 16324 169864 34770566
Infusion related reaction 41.60 13.68 83 16418 52974 34887456
Nerve degeneration 41.01 13.68 11 16490 197 34940233
Mobility decreased 40.66 13.68 60 16441 30068 34910362
Bone density decreased 39.65 13.68 19 16482 1910 34938520
Osteoporosis 38.28 13.68 38 16463 12630 34927800
Pain 36.75 13.68 192 16309 204483 34735947
Bronchial obstruction 36.54 13.68 17 16484 1599 34938831
Breath sounds abnormal 35.58 13.68 28 16473 6853 34933577
Completed suicide 35.18 13.68 3 16498 98165 34842265
Hernia 35.15 13.68 32 16469 9551 34930879
Drug interaction 35.11 13.68 33 16468 225913 34714517
Therapy partial responder 35.06 13.68 32 16469 9584 34930846
Blood pressure diastolic abnormal 34.84 13.68 24 16477 4794 34935636
Renal neoplasm 33.60 13.68 15 16486 1282 34939148
Musculoskeletal stiffness 33.02 13.68 70 16431 46610 34893820
Hernia pain 32.95 13.68 10 16491 283 34940147
Cataract 32.28 13.68 50 16451 26136 34914294
Death 31.94 13.68 90 16411 397959 34542471
Blood pressure systolic abnormal 31.74 13.68 21 16480 3927 34936503
Oxygen saturation decreased 31.67 13.68 75 16426 53743 34886687
Osteomyelitis 30.72 13.68 38 16463 16098 34924332
Febrile neutropenia 29.27 13.68 14 16487 136835 34803595
Osteonecrosis of jaw 29.15 13.68 39 16462 17850 34922580
Oesophageal rupture 28.98 13.68 10 16491 429 34940001
Blood pressure diastolic decreased 28.82 13.68 28 16473 9066 34931364
Joint injury 28.61 13.68 28 16473 9145 34931285
Tibia fracture 28.06 13.68 14 16487 1536 34938894
Pyelonephritis acute 27.03 13.68 15 16486 2044 34938386
Pulmonary fibrosis 26.80 13.68 38 16463 18358 34922072
Blood pressure fluctuation 26.74 13.68 45 16456 25204 34915226
Acute kidney injury 26.68 13.68 66 16435 304922 34635508
Arthritis 25.72 13.68 50 16451 31296 34909134
Thrombocytopenia 25.22 13.68 22 16479 156225 34784205
Respiratory rate increased 25.06 13.68 27 16474 9867 34930563
Blood pressure diastolic increased 25.02 13.68 20 16481 5005 34935425
Embolic stroke 24.94 13.68 19 16482 4435 34935995
Rheumatoid lung 24.74 13.68 11 16490 931 34939499
Product dose omission issue 24.46 13.68 13 16488 119698 34820732
Post infection glomerulonephritis 24.30 13.68 6 16495 76 34940354
Nasopharyngitis 23.87 13.68 80 16421 69888 34870542
Wheezing 23.60 13.68 57 16444 41345 34899085
Ureteric stenosis 22.41 13.68 11 16490 1165 34939265
Eosinophilic granulomatosis with polyangiitis 22.12 13.68 13 16488 1974 34938456
Panniculitis 22.08 13.68 13 16488 1981 34938449
Infection 21.92 13.68 93 16408 90822 34849608
Fibula fracture 21.70 13.68 10 16491 920 34939510
Middle ear effusion 21.69 13.68 9 16492 643 34939787
Stress fracture 21.57 13.68 10 16491 933 34939497
Gynaecomastia 21.05 13.68 25 16476 10155 34930275
Pulmonary function test decreased 21.02 13.68 18 16483 4957 34935473
Abdominal rigidity 20.92 13.68 11 16490 1346 34939084
Granuloma 20.74 13.68 15 16486 3236 34937194
Osteonecrosis 20.58 13.68 30 16471 14860 34925570
Lung neoplasm malignant 19.76 13.68 32 16469 17363 34923067
Stress 19.73 13.68 44 16457 30303 34910127
Fear of injection 19.54 13.68 11 16490 1541 34938889
Scleritis 19.49 13.68 8 16493 556 34939874
Red blood cell sedimentation rate 19.37 13.68 10 16491 1178 34939252
Distal intestinal obstruction syndrome 19.28 13.68 7 16494 349 34940081
Wound 19.18 13.68 29 16472 14835 34925595
Joint swelling 19.13 13.68 67 16434 59823 34880607
Lower respiratory tract congestion 19.07 13.68 10 16491 1217 34939213
Arterial occlusive disease 18.96 13.68 16 16485 4318 34936112
Granuloma skin 18.68 13.68 10 16491 1269 34939161
Arthropathy 18.61 13.68 40 16461 26867 34913563
Impaired healing 18.50 13.68 29 16472 15305 34925125
Lymphocele 18.12 13.68 10 16491 1347 34939083
Renal mass 18.00 13.68 11 16490 1793 34938637
Weight increased 17.85 13.68 89 16412 92944 34847486
Fracture displacement 17.80 13.68 5 16496 107 34940323
Hyperintensity in brain deep nuclei 17.76 13.68 5 16496 108 34940322
Disease progression 17.69 13.68 15 16486 108062 34832368
Sensory disturbance 17.69 13.68 18 16483 6159 34934271
Heart rate increased 17.62 13.68 55 16446 46288 34894142
Nasal disorder 17.33 13.68 11 16490 1917 34938513
Nasal neoplasm 17.26 13.68 5 16496 120 34940310
Epididymitis 17.19 13.68 12 16489 2447 34937983
Herpes zoster 17.13 13.68 45 16456 34354 34906076
Atypical fracture 17.10 13.68 5 16496 124 34940306
Intestinal prolapse 16.88 13.68 5 16496 130 34940300
Bronchomalacia 16.88 13.68 5 16496 130 34940300
Spinal fracture 16.48 13.68 19 16482 7479 34932951
Joint effusion 16.47 13.68 16 16485 5177 34935253
Immunoglobulin G4 related disease 16.39 13.68 5 16496 144 34940286
Phlebosclerosis 16.29 13.68 5 16496 147 34940283
Nocturia 16.23 13.68 22 16479 10188 34930242
Extraskeletal ossification 16.18 13.68 4 16497 51 34940379
Cardiac arrest 16.17 13.68 13 16488 96146 34844284
Purpura 16.06 13.68 22 16479 10289 34930141
Hypokalaemia 15.79 13.68 4 16497 58210 34882220
Anaemia 15.68 13.68 57 16444 233278 34707152
Vein disorder 15.63 13.68 9 16492 1316 34939114
Noninfective encephalitis 15.20 13.68 5 16496 185 34940245
Fracture nonunion 15.07 13.68 5 16496 190 34940240
Limb discomfort 14.89 13.68 22 16479 11025 34929405
Elbow deformity 14.85 13.68 5 16496 199 34940231
Pathological fracture 14.82 13.68 14 16487 4377 34936053
Extranodal marginal zone B-cell lymphoma (MALT type) 14.75 13.68 5 16496 203 34940227
Asthma 14.74 13.68 49 16452 42607 34897823
Blood parathyroid hormone decreased 14.70 13.68 9 16492 1471 34938959
Drug tolerance decreased 14.70 13.68 10 16491 1957 34938473
Pain in extremity 14.61 13.68 106 16395 126407 34814023
Fracture 14.46 13.68 17 16484 6832 34933598
Gastrooesophageal reflux disease 14.40 13.68 45 16456 37879 34902551
Interstitial lung disease 14.37 13.68 65 16436 65217 34875213
Lower respiratory tract infection 14.36 13.68 40 16461 31597 34908833
Skin ulcer 14.20 13.68 32 16469 22184 34918246
Dizziness postural 14.19 13.68 16 16485 6148 34934282
Central nervous system inflammation 14.17 13.68 5 16496 229 34940201
Cough 14.14 13.68 120 16381 150020 34790410
Hypersensitivity vasculitis 13.95 13.68 12 16489 3323 34937107
Rales 13.79 13.68 20 16481 9863 34930567
Musculoskeletal discomfort 13.77 13.68 18 16483 8050 34932380
Low turnover osteopathy 13.73 13.68 4 16497 98 34940332
Genital lesion 13.70 13.68 5 16496 253 34940177

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Atypical femur fracture 590.31 11.17 234 109315 4955 79629884
Femur fracture 584.87 11.17 459 109090 38193 79596646
Rheumatoid arthritis 494.55 11.17 964 108585 207506 79427333
Stress fracture 397.54 11.17 189 109360 6291 79628548
Toxicity to various agents 322.64 11.17 90 109459 421450 79213389
Osteonecrosis of jaw 314.78 11.17 341 109208 42885 79591954
Fracture displacement 302.26 11.17 100 109449 1228 79633611
Low turnover osteopathy 299.43 11.17 110 109439 1876 79632963
Death 292.02 11.17 212 109337 566302 79068537
Completed suicide 289.45 11.17 11 109538 245756 79389083
Mobility decreased 286.94 11.17 563 108986 121612 79513227
Blood pressure systolic increased 265.63 11.17 390 109159 66596 79568243
Osteoarthritis 243.25 11.17 433 109116 86876 79547963
Arthralgia 232.59 11.17 1460 108089 570343 79064496
Pathological fracture 212.95 11.17 149 109400 10388 79624451
Pulmonary fibrosis 206.30 11.17 278 109271 43834 79591005
Osteoporosis 205.83 11.17 309 109240 53803 79581036
Acute kidney injury 198.15 11.17 254 109295 519150 79115689
Arthropathy 197.37 11.17 613 108936 176498 79458341
Foot fracture 195.33 11.17 193 109356 21788 79613051
Foot deformity 185.96 11.17 196 109353 23878 79610961
Drug abuse 185.80 11.17 9 109540 162682 79472157
Musculoskeletal stiffness 177.95 11.17 587 108962 174421 79460418
Febrile neutropenia 177.13 11.17 49 109500 230950 79403889
Nodule 170.17 11.17 183 109366 22811 79612028
Neutropenia 169.55 11.17 92 109457 287618 79347221
Rheumatoid nodule 167.88 11.17 160 109389 17278 79617561
Jaw disorder 166.63 11.17 97 109452 4909 79629930
Osteomyelitis 164.27 11.17 214 109335 32651 79602188
Bone disorder 160.95 11.17 163 109386 18950 79615889
Drug interaction 157.23 11.17 204 109345 414979 79219860
Lower limb fracture 154.91 11.17 175 109374 23040 79611799
Asthma 151.76 11.17 469 109080 134626 79500213
Osteonecrosis 148.50 11.17 198 109351 30897 79603942
Fracture nonunion 146.88 11.17 61 109488 1461 79633378
Contraindicated product administered 145.71 11.17 512 109037 157026 79477813
Disease progression 137.82 11.17 41 109508 184321 79450518
Osteopenia 135.62 11.17 146 109403 18218 79616621
Cardiac arrest 134.74 11.17 35 109514 172061 79462778
Gastrooesophageal reflux disease 134.30 11.17 380 109169 103866 79530973
Atypical fracture 132.50 11.17 46 109503 660 79634179
Synovitis 125.11 11.17 473 109076 150261 79484578
Intentional overdose 123.80 11.17 5 109544 105955 79528884
Tooth disorder 123.67 11.17 166 109383 26067 79608772
Loss of personal independence in daily activities 122.57 11.17 364 109185 102216 79532623
Thrombocytopenia 121.75 11.17 111 109438 265148 79369691
Drug intolerance 120.72 11.17 696 108853 263423 79371416
Fibromyalgia 120.05 11.17 270 109279 64070 79570769
Wheezing 119.13 11.17 392 109157 116272 79518567
Treatment failure 115.26 11.17 502 109047 169984 79464855
Sepsis 114.13 11.17 121 109428 269307 79365532
Systemic lupus erythematosus rash 113.31 11.17 54 109495 1806 79633033
Bedridden 110.93 11.17 108 109441 11971 79622868
Inflammation 110.41 11.17 331 109218 93422 79541417
Rheumatoid factor positive 110.40 11.17 250 109299 59589 79575250
Fracture delayed union 109.78 11.17 55 109494 2055 79632784
Blood parathyroid hormone decreased 109.73 11.17 101 109448 10435 79624404
Pain in extremity 104.80 11.17 857 108692 363681 79271158
Presbyacusis 103.26 11.17 57 109492 2603 79632236
Rheumatic fever 102.94 11.17 159 109390 28366 79606473
Impaired healing 102.78 11.17 309 109240 87346 79547493
Joint swelling 101.74 11.17 712 108837 287934 79346905
Drug hypersensitivity 99.95 11.17 728 108821 298188 79336651
Red blood cell sedimentation rate abnormal 99.34 11.17 133 109416 20830 79614009
Malignant neoplasm progression 96.72 11.17 33 109516 135957 79498882
Arthritis 96.54 11.17 362 109187 114518 79520321
Blood pressure diastolic abnormal 94.34 11.17 124 109425 19078 79615761
Panniculitis 94.25 11.17 100 109449 12271 79622568
Infection 94.00 11.17 611 108938 241101 79393738
Pleural fibrosis 93.84 11.17 63 109486 4104 79630735
Pelvic fracture 93.60 11.17 99 109450 12105 79622734
Swollen joint count increased 93.03 11.17 135 109414 22792 79612047
Bone sequestrum 91.48 11.17 41 109508 1188 79633651
Blood pressure diastolic decreased 89.47 11.17 154 109395 30062 79604777
Product dose omission issue 89.17 11.17 126 109423 247411 79387428
Alanine aminotransferase abnormal 88.48 11.17 83 109466 8784 79626055
Seizure 87.83 11.17 78 109471 188756 79446083
Infusion related reaction 86.49 11.17 577 108972 229660 79405179
COVID-19 86.33 11.17 55 109494 157619 79477220
Red blood cell sedimentation rate increased 85.92 11.17 193 109356 45749 79589090
Type 2 diabetes mellitus 85.36 11.17 220 109329 56902 79577937
Granuloma skin 84.19 11.17 82 109467 9092 79625747
Anaemia 81.37 11.17 325 109224 444690 79190149
Blood pressure systolic abnormal 81.08 11.17 109 109440 17138 79617701
Somnolence 79.92 11.17 128 109421 238853 79395986
Pleural thickening 79.20 11.17 50 109499 2932 79631907
Respiratory failure 79.12 11.17 79 109470 180832 79454007
Osteogenesis imperfecta 79.07 11.17 29 109520 492 79634347
Fear of injection 78.52 11.17 72 109477 7402 79627437
Osteosclerosis 77.56 11.17 55 109494 3916 79630923
Ankle arthroplasty 77.14 11.17 39 109510 1486 79633353
Adjustment disorder with depressed mood 75.60 11.17 77 109472 9009 79625830
Red blood cell sedimentation rate 75.43 11.17 62 109487 5503 79629336
Dental caries 75.30 11.17 87 109462 11733 79623106
Blood pressure fluctuation 72.47 11.17 230 109319 66915 79567924
Multiple organ dysfunction syndrome 71.42 11.17 38 109511 120208 79514631
Dehydration 71.30 11.17 146 109403 248041 79386798
Joint range of motion decreased 70.45 11.17 147 109402 33135 79601704
Obstructive airways disorder 70.18 11.17 142 109407 31317 79603522
Foot operation 69.72 11.17 60 109489 5673 79629166
Anaemia postoperative 69.58 11.17 39 109510 1835 79633004
Eosinophilic bronchitis 69.57 11.17 26 109523 466 79634373
Tooth infection 69.40 11.17 106 109443 18726 79616113
Salpingo-oophorectomy unilateral 69.11 11.17 30 109519 804 79634035
Nerve injury 68.17 11.17 74 109475 9318 79625521
Ill-defined disorder 67.79 11.17 222 109327 65653 79569186
Blood magnesium increased 67.19 11.17 48 109501 3458 79631381
Sciatica 67.15 11.17 144 109405 33078 79601761
Tachycardia 66.50 11.17 88 109461 177680 79457159
Deep vein thrombosis postoperative 64.93 11.17 77 109472 10675 79624164
C-reactive protein abnormal 64.90 11.17 179 109370 48188 79586651
Skin necrosis 64.12 11.17 100 109449 17987 79616852
Renal failure 64.07 11.17 111 109438 200857 79433982
Drug tolerance decreased 64.05 11.17 84 109465 12894 79621945
Deafness neurosensory 63.95 11.17 62 109487 6836 79628003
Overdose 63.15 11.17 97 109452 184109 79450730
Blood pressure increased 62.85 11.17 501 109048 210859 79423980
Ulcer 61.83 11.17 131 109418 29841 79604998
Sinusitis fungal 61.04 11.17 39 109510 2335 79632504
Suicide attempt 60.94 11.17 19 109530 82913 79551926
Basal cell carcinoma 60.07 11.17 148 109401 37227 79597612
Lactic acidosis 59.65 11.17 12 109537 70347 79564492
Autoimmune disorder 59.10 11.17 92 109457 16520 79618319
Pancytopenia 59.03 11.17 85 109464 165660 79469179
Periodontal disease 58.99 11.17 35 109514 1835 79633004
Hyperkalaemia 58.49 11.17 43 109506 114355 79520484
Pyrexia 58.22 11.17 624 108925 678085 78956754
Depressed level of consciousness 58.20 11.17 30 109519 96622 79538217
Coma 58.04 11.17 33 109516 100616 79534223
Heart rate decreased 57.75 11.17 220 109329 70096 79564743
Drug tolerance 57.20 11.17 65 109484 8610 79626229
Peri-implantitis 56.11 11.17 18 109531 199 79634640
Bursitis 55.57 11.17 140 109409 35704 79599135
Platelet count decreased 54.64 11.17 116 109433 194548 79440291
Ulna fracture 54.20 11.17 28 109521 1117 79633722
Exostosis 54.00 11.17 89 109460 16769 79618070
Tendonitis 53.68 11.17 108 109441 23722 79611117
Muscle fatigue 53.64 11.17 42 109507 3477 79631362
Resorption bone increased 52.88 11.17 30 109519 1445 79633394
Comminuted fracture 52.86 11.17 23 109526 620 79634219
Joint destruction 52.58 11.17 52 109497 5873 79628966
Joint injury 52.40 11.17 126 109423 31209 79603630
Blood cholesterol increased 52.37 11.17 241 109308 83479 79551360
Diverticulum 52.30 11.17 82 109467 14814 79620025
Respiratory symptom 51.99 11.17 47 109502 4744 79630095
Therapeutic product effect decreased 51.79 11.17 394 109155 163469 79471370
Oedema 51.23 11.17 310 109239 119270 79515569
Anti-cyclic citrullinated peptide antibody positive 51.02 11.17 238 109311 82905 79551934
Blood pressure diastolic increased 50.99 11.17 80 109469 14462 79620377
Breath sounds abnormal 50.68 11.17 84 109465 15900 79618939
Bone cyst 50.24 11.17 40 109509 3393 79631446
Fall 50.04 11.17 944 108605 486685 79148154
Bradycardia 49.78 11.17 68 109481 135489 79499350
Intentional product misuse 49.65 11.17 35 109514 95130 79539709
Fracture 49.34 11.17 99 109450 21702 79613137
Wrong technique in product usage process 49.03 11.17 20 109529 73855 79560984
Bone density decreased 49.00 11.17 75 109474 13272 79621567
Periodontitis 48.58 11.17 44 109505 4452 79630387
Dislocation of vertebra 48.52 11.17 57 109492 7823 79627016
Mucosal inflammation 47.72 11.17 22 109527 75558 79559281
Pruritus 47.54 11.17 332 109217 394316 79240523
Syncope 47.04 11.17 111 109438 179338 79455501
Carpal tunnel syndrome 47.00 11.17 91 109458 19437 79615402
Osteonecrosis of external auditory canal 46.50 11.17 15 109534 169 79634670
Gingivitis 45.47 11.17 59 109490 8962 79625877
Bone erosion 45.21 11.17 85 109464 17762 79617077
Epigastric discomfort 45.15 11.17 55 109494 7841 79626998
Enthesopathy 45.13 11.17 67 109482 11541 79623298
Tooth extraction 44.98 11.17 65 109484 10930 79623909
Lip dry 44.88 11.17 78 109471 15340 79619499
Injection site pain 44.85 11.17 68 109481 129770 79505069
Psoriatic arthropathy 44.76 11.17 219 109330 77780 79557059
Pain 44.75 11.17 1274 108275 702528 78932311
Skin ulcer 44.11 11.17 169 109380 53981 79580858
Wound infection 43.97 11.17 100 109449 23891 79610948
Hypotension 43.93 11.17 390 109159 439927 79194912
Tongue disorder 43.71 11.17 73 109476 13902 79620937
Gingival ulceration 43.69 11.17 23 109526 954 79633885
Cardiac failure 43.67 11.17 92 109457 154750 79480089
Dental fistula 43.63 11.17 19 109530 513 79634326
Electrocardiogram QT prolonged 43.63 11.17 36 109513 90350 79544489
Exostosis of jaw 43.60 11.17 25 109524 1229 79633610
Nasal oedema 43.53 11.17 28 109521 1696 79633143
Neutrophil count decreased 43.44 11.17 39 109510 93920 79540919
Hunger 43.35 11.17 45 109504 5383 79629456
Drug reaction with eosinophilia and systemic symptoms 43.28 11.17 17 109532 64227 79570612
Groin pain 43.17 11.17 70 109479 13010 79621829
Agitation 43.05 11.17 44 109505 99671 79535168
Total lung capacity decreased 42.84 11.17 34 109515 2871 79631968
Loose tooth 42.82 11.17 35 109514 3082 79631757
Purulent discharge 42.82 11.17 47 109502 5992 79628847
Hypercalcaemia 42.71 11.17 133 109416 38297 79596542
Tooth fracture 42.62 11.17 65 109484 11465 79623374
Adverse drug reaction 42.17 11.17 192 109357 66200 79568639
Prescribed overdose 42.00 11.17 131 109418 37752 79597087
Therapeutic product effect variable 41.97 11.17 29 109520 1980 79632859
Gingival disorder 41.96 11.17 37 109512 3614 79631225
Peripheral venous disease 41.84 11.17 77 109472 15832 79619007
Sedation 41.67 11.17 10 109539 51885 79582954
Cyst 41.57 11.17 71 109478 13769 79621070
Walking aid user 41.52 11.17 60 109489 10088 79624751
Oral cavity fistula 41.47 11.17 20 109529 687 79634152
Neoplasm progression 41.42 11.17 10 109539 51672 79583167
Bunion operation 41.41 11.17 22 109527 930 79633909
Leukopenia 41.23 11.17 60 109489 116453 79518386
Rheumatoid lung 40.95 11.17 39 109510 4206 79630633
Respiratory arrest 40.84 11.17 14 109535 57536 79577303
Drug resistance 40.75 11.17 5 109544 42208 79592631
Wheelchair user 40.52 11.17 46 109503 6086 79628753
Constipation 40.33 11.17 226 109323 282824 79352015
Bone formation decreased 40.05 11.17 11 109538 67 79634772
Suicidal ideation 39.92 11.17 28 109521 76312 79558527
Polyarthritis 39.86 11.17 65 109484 12137 79622702
Granuloma 39.86 11.17 53 109496 8244 79626595
Anaphylactic reaction 39.63 11.17 34 109515 83709 79551130
Oral herpes 39.23 11.17 104 109445 27350 79607489
Injection site erythema 39.18 11.17 30 109519 78167 79556672
Embolism venous 39.11 11.17 38 109511 4201 79630638
Tibia fracture 38.49 11.17 42 109507 5319 79629520
Metabolic acidosis 38.46 11.17 34 109515 82495 79552344
Myelosuppression 38.35 11.17 5 109544 40291 79594548
Limb asymmetry 38.30 11.17 18 109531 583 79634256
Cardio-respiratory arrest 38.28 11.17 56 109493 108454 79526385
Bone loss 37.76 11.17 30 109519 2537 79632302
Therapy cessation 37.38 11.17 4 109545 37558 79597281
Body temperature decreased 37.35 11.17 113 109436 32032 79602807
No adverse event 36.91 11.17 4 109545 37188 79597651
Limb discomfort 36.79 11.17 114 109435 32736 79602103
Hypertension 36.78 11.17 649 108900 330343 79304496
Product use in unapproved indication 36.70 11.17 198 109351 250161 79384678
White blood cell count decreased 36.60 11.17 134 109415 188154 79446685
Hypersensitivity 36.57 11.17 534 109015 261705 79373134
Respiratory tract congestion 36.38 11.17 83 109466 19871 79614968
Oral infection 36.34 11.17 42 109507 5665 79629174
Hiatus hernia 36.08 11.17 91 109458 23221 79611618
Hallucination 35.71 11.17 39 109510 85706 79549133
Serotonin syndrome 35.52 11.17 9 109540 45018 79589821
Facet joint syndrome 35.30 11.17 59 109490 11243 79623596
Acute respiratory failure 35.08 11.17 19 109530 59522 79575317
Sputum increased 34.63 11.17 37 109512 4576 79630263
Breast cancer stage III 34.37 11.17 54 109495 9772 79625067
Immobile 34.20 11.17 45 109504 6928 79627911
C-reactive protein 34.01 11.17 38 109511 4941 79629898
Liver injury 33.95 11.17 161 109388 56453 79578386
Dysarthria 33.81 11.17 26 109523 67596 79567243
Jaw fracture 33.53 11.17 30 109519 2987 79631852
Abnormal behaviour 33.53 11.17 5 109544 36416 79598423
Cardiac failure congestive 33.52 11.17 93 109456 142309 79492530
Sleep disorder 33.50 11.17 217 109332 85460 79549379
Intentional self-injury 33.45 11.17 3 109546 32416 79602423
Tenosynovitis 33.26 11.17 69 109480 15485 79619354
Coagulopathy 33.01 11.17 5 109544 36001 79598838
Hypervolaemia 32.79 11.17 9 109540 42681 79592158
Cytomegalovirus infection 32.74 11.17 9 109540 42635 79592204
Acute phase reaction 32.71 11.17 14 109535 362 79634477
Deformity 32.52 11.17 52 109497 9553 79625286
Nasal polyps 32.46 11.17 45 109504 7282 79627557
Thoracic vertebral fracture 32.35 11.17 38 109511 5215 79629624
Drug ineffective for unapproved indication 32.21 11.17 15 109534 51223 79583616
Accidental exposure to product 32.05 11.17 3 109546 31319 79603520
Live birth 32.02 11.17 76 109473 18668 79616171
Aggression 31.91 11.17 15 109534 50943 79583896
Metaphyseal corner fracture 31.90 11.17 8 109541 32 79634807
Polymyalgia rheumatica 31.63 11.17 35 109514 4502 79630337
Fistula discharge 31.57 11.17 21 109528 1347 79633492
Bronchopulmonary aspergillosis allergic 31.21 11.17 29 109520 3032 79631807
Drug eruption 30.90 11.17 131 109418 43804 79591035
X-ray abnormal 30.84 11.17 39 109510 5774 79629065
Gait inability 30.69 11.17 161 109388 58756 79576083
Bone fragmentation 30.61 11.17 16 109533 654 79634185
Pain in jaw 30.46 11.17 135 109414 46016 79588823
Spinal compression fracture 30.32 11.17 70 109479 16888 79617951
Swelling 30.09 11.17 441 109108 216270 79418569
Oxygen saturation decreased 30.06 11.17 290 109259 128757 79506082
Rales 29.83 11.17 77 109472 19924 79614915
Sputum discoloured 29.69 11.17 81 109468 21662 79613177
Palmar-plantar erythrodysaesthesia syndrome 29.48 11.17 5 109544 33129 79601710
Hypoxia 29.39 11.17 61 109488 103182 79531657
Sopor 29.33 11.17 5 109544 33005 79601834
Diastolic dysfunction 29.28 11.17 53 109496 10758 79624081
Gait disturbance 29.09 11.17 423 109126 207083 79427756
Obesity 28.91 11.17 110 109439 35015 79599824
Periprosthetic fracture 28.79 11.17 15 109534 609 79634230
Temporomandibular joint syndrome 28.75 11.17 31 109518 3874 79630965
Spinal disorder 28.69 11.17 51 109498 10209 79624630
Female genital tract fistula 28.45 11.17 38 109511 5937 79628902
Therapeutic response decreased 28.42 11.17 173 109376 66680 79568159
Mental status changes 28.39 11.17 30 109519 66929 79567910
Product prescribing error 28.36 11.17 13 109536 44800 79590039
Dry mouth 27.99 11.17 212 109337 87807 79547032
Tooth abscess 27.99 11.17 66 109483 16144 79618695
Haematuria 27.91 11.17 32 109517 68804 79566035
Gingival swelling 27.82 11.17 33 109516 4576 79630263
Emphysema 27.74 11.17 66 109483 16234 79618605
Bone marrow failure 27.72 11.17 18 109531 51089 79583750
Encephalopathy 27.69 11.17 31 109518 67366 79567473
Hepatic failure 27.59 11.17 26 109523 61186 79573653
Arteriovenous fistula occlusion 27.58 11.17 14 109535 538 79634301
Hand deformity 27.48 11.17 240 109309 103679 79531160
Bone density abnormal 27.42 11.17 27 109522 3033 79631806
Labelled drug-drug interaction medication error 27.37 11.17 3 109546 27647 79607192
Therapy interrupted 27.30 11.17 5 109544 31336 79603503
Neuroleptic malignant syndrome 27.26 11.17 3 109546 27556 79607283
Rotator cuff syndrome 27.23 11.17 60 109489 14035 79620804
Unresponsive to stimuli 27.20 11.17 22 109527 55766 79579073
Granulomatosis with polyangiitis 26.99 11.17 26 109523 2844 79631995
Abscess jaw 26.95 11.17 21 109528 1726 79633113
Tremor 26.90 11.17 131 109418 169952 79464887
Immunodeficiency 26.70 11.17 78 109471 21690 79613149
Blue toe syndrome 26.68 11.17 14 109535 577 79634262
Fracture malunion 26.39 11.17 9 109540 122 79634717
Withdrawal syndrome 26.37 11.17 3 109546 26851 79607988
Bone graft 26.35 11.17 15 109534 727 79634112
Pulmonary embolism 26.12 11.17 134 109415 171520 79463319
Bone pain 26.12 11.17 148 109401 55594 79579245
Dyspnoea 25.98 11.17 940 108609 856085 78778754
Nerve degeneration 25.86 11.17 11 109538 280 79634559
Malocclusion 25.74 11.17 9 109540 132 79634707
Lacrimal disorder 25.70 11.17 13 109536 496 79634343
Injection site pruritus 25.64 11.17 13 109536 42270 79592569
Cough 25.49 11.17 672 108877 366117 79268722
Ventricular tachycardia 25.26 11.17 13 109536 41922 79592917
Respiratory rate increased 25.16 11.17 76 109473 21524 79613315
Adverse event 25.08 11.17 155 109394 60059 79574780
Rash maculo-papular 25.06 11.17 24 109525 56054 79578785
Acute myocardial infarction 25.03 11.17 42 109507 76994 79557845
Adrenal insufficiency 24.94 11.17 91 109458 28396 79606443
Lethargy 24.90 11.17 46 109503 81246 79553593
Pancreatitis acute 24.89 11.17 19 109530 49585 79585254
Meniscus injury 24.80 11.17 38 109511 6730 79628109
Lung opacity 24.78 11.17 33 109516 5141 79629698
Kidney infection 24.63 11.17 76 109473 21775 79613064
Femoral neck fracture 24.61 11.17 47 109502 9937 79624902
Irritability 24.43 11.17 13 109536 41131 79593708
Brain oedema 24.37 11.17 3 109546 25260 79609579
Tachypnoea 24.18 11.17 7 109542 32056 79602783
Device failure 24.14 11.17 36 109513 6225 79628614
Hypoaesthesia 24.11 11.17 363 109186 178989 79455850
Dental necrosis 23.90 11.17 9 109540 165 79634674
Feeling abnormal 23.82 11.17 125 109424 159074 79475765
Stevens-Johnson syndrome 23.81 11.17 12 109537 39154 79595685
Fracture pain 23.80 11.17 14 109535 722 79634117
Cardiogenic shock 23.79 11.17 14 109535 41900 79592939
Lumbar vertebral fracture 23.75 11.17 38 109511 6984 79627855
Pulmonary arterial hypertension 23.71 11.17 5 109544 28361 79606478
Drug withdrawal syndrome 23.69 11.17 9 109540 34709 79600130
Abdominal discomfort 23.49 11.17 479 109070 250248 79384591
Mass excision 23.47 11.17 11 109538 354 79634485
Spinal fracture 23.41 11.17 66 109483 17988 79616851
Endometrial disorder 23.34 11.17 13 109536 604 79634235
International normalised ratio increased 23.33 11.17 51 109498 84670 79550169
Intentional product use issue 23.30 11.17 315 109234 151797 79483042
Gastrointestinal haemorrhage 23.23 11.17 114 109435 147605 79487234
Hyperhidrosis 23.20 11.17 118 109431 151374 79483465
Oral disorder 23.03 11.17 46 109503 10049 79624790
Toothache 23.01 11.17 70 109479 19900 79614939
Therapy non-responder 22.77 11.17 210 109339 92095 79542744
Dyskinesia 22.66 11.17 17 109532 44756 79590083
Bronchiectasis 22.63 11.17 75 109474 22311 79612528
Duodenal ulcer perforation 22.49 11.17 162 109387 66049 79568790
Confusional state 22.35 11.17 305 109244 317692 79317147
Radius fracture 22.31 11.17 26 109523 3538 79631301
Wrist fracture 22.19 11.17 50 109499 11871 79622968
Dry eye 22.12 11.17 105 109444 36826 79598013
Acute respiratory distress syndrome 21.96 11.17 17 109532 44050 79590789
Grip strength decreased 21.86 11.17 73 109476 21796 79613043
Restlessness 21.84 11.17 19 109530 46473 79588366
Eosinophilic granulomatosis with polyangiitis 21.75 11.17 26 109523 3634 79631205
Respiratory distress 21.68 11.17 29 109520 58310 79576529
Malaise 21.39 11.17 849 108700 489020 79145819
Drug dependence 21.25 11.17 15 109534 40754 79594085
Pulmonary oedema 21.24 11.17 57 109492 88197 79546642
Toxic epidermal necrolysis 21.21 11.17 18 109531 44563 79590276
Hyperbilirubinaemia 21.16 11.17 4 109545 24514 79610325
Extrapyramidal disorder 21.14 11.17 3 109546 22676 79612163
Septic shock 20.94 11.17 92 109457 122709 79512130
Blood calcium increased 20.92 11.17 45 109504 10355 79624484
Tooth loss 20.86 11.17 36 109513 7039 79627800
Uterine disorder 20.76 11.17 20 109529 2187 79632652
Angioedema 20.74 11.17 46 109503 75989 79558850
Hyponatraemia 20.70 11.17 151 109398 177697 79457142
Bronchopulmonary aspergillosis 20.66 11.17 3 109546 22291 79612548
Hernia pain 20.64 11.17 11 109538 468 79634371
Psychotic disorder 20.59 11.17 16 109533 41386 79593453
Nasopharyngitis 20.57 11.17 475 109074 253406 79381433
Generalised tonic-clonic seizure 20.56 11.17 18 109531 43892 79590947
COVID-19 pneumonia 20.50 11.17 7 109542 28842 79605997
Ascites 20.38 11.17 46 109503 75516 79559323
Cystitis escherichia 20.33 11.17 12 109537 623 79634216
Hepatic enzyme increased 20.23 11.17 358 109191 182252 79452587
Disturbance in attention 20.18 11.17 24 109525 50777 79584062
Haemophagocytic lymphohistiocytosis 20.09 11.17 3 109546 21834 79613005
Barrett's oesophagus 20.08 11.17 13 109536 796 79634043
Bacteraemia 20.04 11.17 10 109539 32814 79602025
Diabetic ketoacidosis 19.94 11.17 11 109538 34111 79600728
Skeletal injury 19.90 11.17 16 109533 1376 79633463
Status epilepticus 19.76 11.17 5 109544 25036 79609803
Lung disorder 19.73 11.17 183 109366 80374 79554465
C-reactive protein increased 19.67 11.17 267 109282 128760 79506079
Rheumatoid factor 19.66 11.17 10 109539 386 79634453
Liver disorder 19.53 11.17 168 109381 72249 79562590
Vision blurred 19.51 11.17 77 109472 105821 79529018
Poor venous access 19.42 11.17 62 109487 18087 79616752
Weight bearing difficulty 19.34 11.17 23 109526 3198 79631641
Altered state of consciousness 19.30 11.17 19 109530 43803 79591036
Pseudarthrosis 19.22 11.17 9 109540 289 79634550
Nail bed inflammation 19.22 11.17 11 109538 539 79634300
Cerumen impaction 19.21 11.17 15 109534 1237 79633602
Road traffic accident 19.20 11.17 114 109435 43550 79591289
Lymphopenia 19.12 11.17 9 109540 30548 79604291
Flushing 19.06 11.17 60 109489 88208 79546631
Injection site bruising 18.97 11.17 17 109532 40985 79593854
Haemorrhage 18.94 11.17 63 109486 91055 79543784
Eosinophil count increased 18.82 11.17 59 109490 17046 79617793
Giant cell arteritis 18.80 11.17 21 109528 2730 79632109
Lower respiratory tract infection 18.73 11.17 265 109284 128955 79505884
Hypoglycaemia 18.63 11.17 74 109475 101520 79533319
Palmoplantar pustulosis 18.62 11.17 11 109538 572 79634267
Hysterectomy 18.61 11.17 32 109517 6240 79628599
Pemphigus 18.58 11.17 214 109335 99368 79535471
Polyp 18.56 11.17 37 109512 8070 79626769
Pallor 18.48 11.17 25 109524 50037 79584802
Injury 18.46 11.17 175 109374 77321 79557518
Lower respiratory tract congestion 18.39 11.17 25 109524 3972 79630867
Exposed bone in jaw 18.24 11.17 24 109525 3696 79631143
Eczema 18.23 11.17 107 109442 40711 79594128
Urethral caruncle 18.18 11.17 6 109543 73 79634766
Mouth ulceration 18.03 11.17 102 109447 38292 79596547
Vaginal haemorrhage 17.92 11.17 4 109545 21813 79613026
Vitamin B12 decreased 17.78 11.17 23 109526 3482 79631357
Posterior reversible encephalopathy syndrome 17.62 11.17 7 109542 26274 79608565
Accidental overdose 17.62 11.17 17 109532 39564 79595275
Jaw cyst 17.45 11.17 7 109542 153 79634686
Dystonia 17.42 11.17 4 109545 21395 79613444
Edentulous 17.38 11.17 8 109541 247 79634592
Spinal osteoarthritis 17.37 11.17 57 109492 16870 79617969
Pneumonitis 17.28 11.17 36 109513 60824 79574015
Knee arthroplasty 17.18 11.17 110 109439 43138 79591701
Colitis 17.15 11.17 48 109501 73259 79561580
Troponin increased 16.92 11.17 3 109546 19252 79615587
Emotional distress 16.84 11.17 18 109531 39951 79594888
Hip arthroplasty 16.79 11.17 95 109454 35661 79599178
Episcleral hyperaemia 16.78 11.17 3 109546 0 79634839
Vaginal polyp 16.78 11.17 3 109546 0 79634839
Nocturia 16.75 11.17 49 109500 13632 79621207
Apical granuloma 16.61 11.17 5 109544 44 79634795
Abortion spontaneous 16.54 11.17 10 109539 29497 79605342
Sinus bradycardia 16.48 11.17 7 109542 25240 79609599
Ilium fracture 16.48 11.17 8 109541 279 79634560
Post infection glomerulonephritis 16.46 11.17 6 109543 100 79634739
Ejection fraction decreased 16.40 11.17 14 109535 34563 79600276
Urosepsis 16.28 11.17 8 109541 26487 79608352
Renal tubular necrosis 16.26 11.17 7 109542 25032 79609807
Sinus tachycardia 16.25 11.17 16 109533 36892 79597947
Right ventricular failure 16.19 11.17 6 109543 23491 79611348
Skin exfoliation 16.15 11.17 32 109517 55068 79579771
Bone hypertrophy 16.14 11.17 10 109539 567 79634272
Polychondritis 16.10 11.17 10 109539 570 79634269
Abdominal pain upper 16.09 11.17 412 109137 223407 79411432
Oesophageal rupture 16.05 11.17 12 109537 927 79633912
Urine odour abnormal 16.04 11.17 30 109519 6243 79628596
Coronary artery disease 15.97 11.17 42 109507 65432 79569407
Thrombotic microangiopathy 15.97 11.17 4 109545 20165 79614674
Blood potassium increased 15.94 11.17 81 109468 29194 79605645
Myocarditis 15.92 11.17 5 109544 21728 79613111
Acute hepatic failure 15.80 11.17 11 109538 30102 79604737
Nocturnal dyspnoea 15.80 11.17 15 109534 1611 79633228
Night sweats 15.74 11.17 124 109425 51971 79582868
Mastication disorder 15.68 11.17 19 109530 2694 79632145
Cerebral haemorrhage 15.64 11.17 35 109514 57638 79577201
Muscle spasticity 15.63 11.17 5 109544 21470 79613369
Prescribed underdose 15.61 11.17 81 109468 29433 79605406
Device malfunction 15.60 11.17 5 109544 21443 79613396
Diarrhoea 15.52 11.17 1022 108527 879467 78755372
Multiple sclerosis relapse 15.46 11.17 25 109524 46508 79588331
Nodal osteoarthritis 15.38 11.17 10 109539 617 79634222
Chronic sinusitis 15.33 11.17 46 109503 12980 79621859
Traumatic ulcer 15.29 11.17 5 109544 59 79634780
Acute myeloid leukaemia 15.28 11.17 12 109537 30873 79603966
Pancreatitis 15.24 11.17 46 109503 68529 79566310
Interstitial lung disease 15.16 11.17 228 109321 112372 79522467
Full blood count decreased 15.16 11.17 9 109540 26810 79608029
Condition aggravated 15.09 11.17 837 108712 500287 79134552
Blood creatine phosphokinase MB 14.91 11.17 4 109545 22 79634817
Splenomegaly 14.81 11.17 5 109544 20749 79614090
Gastrointestinal disorder 14.77 11.17 243 109306 121962 79512877
Ataxia 14.73 11.17 8 109541 25031 79609808
Respiratory tract inflammation 14.63 11.17 11 109538 857 79633982
Premature delivery 14.55 11.17 7 109542 23460 79611379
Urine calcium/creatinine ratio increased 14.51 11.17 6 109543 142 79634697
Cerebrovascular accident 14.39 11.17 140 109409 155152 79479687
Peripheral swelling 14.36 11.17 478 109071 269139 79365700
Full blood count abnormal 14.31 11.17 100 109449 40374 79594465
Epistaxis 14.30 11.17 92 109457 111423 79523416
Patellofemoral pain syndrome 14.30 11.17 9 109540 525 79634314
Osteitis 14.25 11.17 22 109527 3921 79630918
Tubulointerstitial nephritis 14.21 11.17 19 109530 38216 79596623
Atrophy 14.21 11.17 16 109533 2098 79632741
Hyperaesthesia teeth 14.20 11.17 15 109534 1831 79633008
Product use issue 14.14 11.17 383 109166 209439 79425400
Dry skin 14.14 11.17 47 109502 67948 79566891
Dental alveolar anomaly 14.09 11.17 4 109545 28 79634811
Urinary retention 14.06 11.17 36 109513 56594 79578245
Parophthalmia 14.03 11.17 8 109541 389 79634450
Fluid retention 14.01 11.17 49 109500 69760 79565079
Iron deficiency anaemia 13.95 11.17 71 109478 25601 79609238
Blood pressure inadequately controlled 13.92 11.17 28 109521 6149 79628690
Nasal herpes 13.90 11.17 8 109541 396 79634443
Haemoglobin decreased 13.87 11.17 218 109331 221901 79412938
Rubella 13.85 11.17 6 109543 160 79634679
Muscle rigidity 13.83 11.17 5 109544 19877 79614962
Bone fissure 13.81 11.17 6 109543 161 79634678
Fractured sacrum 13.81 11.17 14 109535 1629 79633210
Polyneuropathy 13.80 11.17 8 109541 24143 79610696
Kyphoscoliosis 13.79 11.17 7 109542 269 79634570
Gastroenteritis viral 13.73 11.17 69 109480 24762 79610077
Acidosis 13.69 11.17 5 109544 19757 79615082
Nausea 13.67 11.17 1131 108418 956065 78678774
Disability 13.59 11.17 53 109496 17067 79617772
Chronic kidney disease 13.57 11.17 46 109503 66108 79568731
Helicobacter infection 13.55 11.17 151 109398 69553 79565286
Vein disorder 13.52 11.17 25 109524 5157 79629682
Escherichia infection 13.46 11.17 4 109545 18013 79616826
Dental plaque 13.46 11.17 5 109544 88 79634751
Pneumonia aspiration 13.44 11.17 47 109502 66920 79567919
Oliguria 13.37 11.17 3 109546 16306 79618533
Fatigue 13.36 11.17 1098 108451 928629 78706210
Neutrophilia 13.32 11.17 32 109517 7919 79626920
Necrotising ulcerative gingivostomatitis 13.31 11.17 4 109545 35 79634804
Unevaluable event 13.30 11.17 36 109513 55549 79579290
Neuropathy peripheral 13.26 11.17 127 109422 141178 79493661
Hepatotoxicity 13.26 11.17 32 109517 51320 79583519
Cataract 13.20 11.17 137 109412 61983 79572856
Renal neoplasm 13.16 11.17 15 109534 1993 79632846
Heart rate increased 13.12 11.17 236 109313 120488 79514351
Deep vein thrombosis 12.97 11.17 105 109444 120814 79514025
Limb injury 12.92 11.17 77 109472 29451 79605388
Blood cholinesterase increased 12.92 11.17 4 109545 39 79634800
Inner ear inflammation 12.89 11.17 3 109546 8 79634831
Nephropathy toxic 12.80 11.17 6 109543 20413 79614426
Cardiac failure acute 12.76 11.17 5 109544 18924 79615915
Miosis 12.76 11.17 3 109546 15786 79619053
Circulatory collapse 12.74 11.17 20 109529 37648 79597191
Disorientation 12.64 11.17 44 109505 62732 79572107
Bone resorption test abnormal 12.63 11.17 3 109546 9 79634830
Spinal stenosis 12.62 11.17 49 109500 15742 79619097
Peripheral sensorimotor neuropathy 12.61 11.17 18 109531 2992 79631847
Musculoskeletal pain 12.54 11.17 204 109345 102150 79532689
Musculoskeletal toxicity 12.50 11.17 6 109543 204 79634635
Hospitalisation 12.47 11.17 77 109472 94159 79540680
Ankle fracture 12.24 11.17 51 109498 16918 79617921
Mood swings 12.22 11.17 6 109543 19874 79614965
Vomiting 12.20 11.17 770 108779 665058 78969781
Musculoskeletal disorder 12.14 11.17 60 109489 21388 79613451
Osteomyelitis chronic 12.04 11.17 9 109540 695 79634144
Thrombosis 12.04 11.17 67 109482 84033 79550806
Haemodialysis 11.92 11.17 5 109544 18163 79616676
Breast cancer stage II 11.84 11.17 31 109518 8089 79626750
Gout 11.76 11.17 10 109539 24739 79610100
Epilepsy 11.75 11.17 24 109525 40836 79594003
Bite 11.71 11.17 8 109541 536 79634303
Anhedonia 11.71 11.17 3 109546 14895 79619944
Injection site rash 11.69 11.17 5 109544 17949 79616890
Injection site swelling 11.67 11.17 30 109519 47102 79587737
Rib fracture 11.67 11.17 72 109477 27875 79606964
Device issue 11.65 11.17 12 109537 27096 79607743
Aplastic anaemia 11.63 11.17 5 109544 17900 79616939
Contusion 11.62 11.17 277 109272 148499 79486340
Rash 11.62 11.17 663 108886 577695 79057144
Herpes zoster 11.58 11.17 186 109363 92897 79541942
Immune thrombocytopenia 11.52 11.17 5 109544 17800 79617039
Product quality issue 11.50 11.17 18 109531 33922 79600917
Metastases to bone 11.45 11.17 10 109539 24417 79610422
Erectile dysfunction 11.43 11.17 3 109546 14661 79620178
Weight decreased 11.42 11.17 597 108952 354601 79280238
Shock 11.35 11.17 27 109522 43521 79591318
Scleritis 11.35 11.17 21 109528 4335 79630504
Mydriasis 11.35 11.17 5 109544 17638 79617201
Osteomalacia 11.34 11.17 12 109537 1468 79633371
Pneumonia 11.33 11.17 768 108781 659478 78975361
Upper gastrointestinal haemorrhage 11.31 11.17 25 109524 41355 79593484
Cytopenia 11.30 11.17 7 109542 20376 79614463
Tendinous contracture 11.28 11.17 5 109544 141 79634698
Weight increased 11.22 11.17 477 109072 276909 79357930
Mental disorder 11.19 11.17 16 109533 31286 79603553

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M05BA07 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates
ATC M05BB02 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB07 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
FDA CS M0006519 Diphosphonates
FDA EPC N0000175579 Bisphosphonate
MeSH PA D050071 Bone Density Conservation Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteitis deformans indication 2089002 DOID:5408
Osteoporosis indication 64859006 DOID:11476
Postmenopausal osteoporosis indication 102447009
Glucocorticoid Induced Osteoporosis indication
Prevention of Glucocorticoid-Induced Osteoporosis indication
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Bone pain contraindication 12584003
Constipation contraindication 14760008 DOID:2089
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Stricture of esophagus contraindication 63305008
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Muscle pain contraindication 68962001
Fracture of femur contraindication 71620000
Duodenitis contraindication 72007001 DOID:8643
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Bed-ridden contraindication 160685001
Osteolysis contraindication 203522001
Esophageal dysmotility contraindication 266434009 DOID:9192
Aseptic necrosis of bone of jaw contraindication 441809006




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.35 acidic
pKa2 6.42 acidic
pKa3 7.4 acidic
pKa4 11.47 acidic
pKa5 12.45 acidic
pKa6 4.27 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
150MG ACTONEL APIL N020835 April 22, 2008 RX TABLET ORAL 7192938 May 6, 2023 PREVENTION AND TREATMENT OF OSTEOPOROSIS
150MG ACTONEL APIL N020835 April 22, 2008 RX TABLET ORAL 7718634 May 6, 2023 TREATMENT OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN
35MG ATELVIA APIL N022560 Oct. 8, 2010 RX TABLET, DELAYED RELEASE ORAL 7645459 Jan. 9, 2028 TREATMENT OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN
35MG ATELVIA APIL N022560 Oct. 8, 2010 RX TABLET, DELAYED RELEASE ORAL 7645460 Jan. 9, 2028 TREATMENT OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Farnesyl pyrophosphate synthase Enzyme INHIBITOR Ki 9.44 CHEMBL CHEMBL
Butyrophilin subfamily 3 member A1 Antibody EC50 7.10 CHEMBL
Farnesyl pyrophosphate synthase Enzyme Ki 7.77 CHEMBL
Farnesyl diphosphate synthase Enzyme IC50 7.13 CHEMBL
Farnesyl diphosphate synthase Enzyme IC50 7.57 CHEMBL
Farnesyl pyrophosphate synthase, EC 2.5.1.1, EC 2.5.1.10 Unclassified Ki 7.80 CHEMBL

External reference:

IDSource
D00942 KEGG_DRUG
329003-65-8 SECONDARY_CAS_RN
353228-19-0 SECONDARY_CAS_RN
115436-72-1 SECONDARY_CAS_RN
4021112 VANDF
4024121 VANDF
C0140610 UMLSCUI
CHEBI:8869 CHEBI
RIS PDB_CHEM_ID
CHEMBL923 ChEMBL_ID
CHEMBL1654 ChEMBL_ID
DB00884 DRUGBANK_ID
D000068296 MESH_DESCRIPTOR_UI
5245 PUBCHEM_CID
3176 IUPHAR_LIGAND_ID
6522 INN_ID
KM2Z91756Z UNII
1356127 RXNORM
107688 MMSL
11659 MMSL
5428 MMSL
d04300 MMSL
007620 NDDF
007621 NDDF
1269159002 SNOMEDCT_US
387064005 SNOMEDCT_US
387582001 SNOMEDCT_US
734872006 SNOMEDCT_US
768538005 SNOMEDCT_US
768539002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-3098 TABLET, FILM COATED 35 mg ORAL ANDA 27 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-3098 TABLET, FILM COATED 35 mg ORAL ANDA 27 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-3099 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-3099 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-3100 TABLET, FILM COATED 30 mg ORAL ANDA 27 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-3100 TABLET, FILM COATED 30 mg ORAL ANDA 27 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7771 TABLET, FILM COATED 150 mg ORAL ANDA 27 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1426 TABLET, DELAYED RELEASE 35 mg ORAL ANDA 30 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0470 TABLET, FILM COATED 25.80 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0470 TABLET, FILM COATED 25.80 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0470 TABLET, FILM COATED 4.20 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0470 TABLET, FILM COATED 4.20 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0471 TABLET, FILM COATED 0.70 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0471 TABLET, FILM COATED 4.30 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0471 TABLET, FILM COATED 4.30 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0471 TABLET, FILM COATED 0.70 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0472 TABLET, FILM COATED 30.10 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0472 TABLET, FILM COATED 30.10 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0472 TABLET, FILM COATED 4.90 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0472 TABLET, FILM COATED 4.90 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0477 TABLET, FILM COATED 10.50 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0477 TABLET, FILM COATED 10.50 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0477 TABLET, FILM COATED 64.50 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0477 TABLET, FILM COATED 64.50 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0478 TABLET, FILM COATED 21 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0478 TABLET, FILM COATED 21 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0478 TABLET, FILM COATED 129 mg ORAL NDA 31 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0478 TABLET, FILM COATED 129 mg ORAL NDA 31 sections
Atelvia HUMAN PRESCRIPTION DRUG LABEL 2 0430-0979 TABLET, DELAYED RELEASE 4.90 mg ORAL NDA 32 sections
Atelvia HUMAN PRESCRIPTION DRUG LABEL 2 0430-0979 TABLET, DELAYED RELEASE 4.90 mg ORAL NDA 32 sections