risedronic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium metabolism regulator, pharmaceutical aid 2387 105462-24-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • risedronate sodium hemi-pentahydrate
  • risedronate sodium monohydrate
  • risedronate sodium anhydrous
  • risedronate sodium hydrate
  • sodium risedronate
  • sodium risedronate hydrate
  • risedronic acid
  • risedronate
  • risedronate sodium
  • actonel
  • risedronic acid monosodium salt
  • risedronic acid monohydrate
A pyridine and diphosphonic acid derivative that acts as a CALCIUM CHANNEL BLOCKER and inhibits BONE RESORPTION.
  • Molecular weight: 283.11
  • Formula: C7H11NO7P2
  • CLOGP: -2.62
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 5
  • TPSA: 148.18
  • ALOGS: -1.43
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O
5 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 87 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.29 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 6.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.76 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 200 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
March 27, 1998 FDA WARNER CHILCOTT LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Femur fracture 809.42 10.06 586 75399 36411 46573666
Atypical femur fracture 677.25 10.06 268 75717 4729 46605348
Low turnover osteopathy 441.64 10.06 189 75796 4100 46605977
Stress fracture 407.15 10.06 209 75776 6918 46603159
Osteoporosis 327.12 10.06 366 75619 40242 46569835
Osteonecrosis of jaw 315.43 10.06 332 75653 34070 46576007
Fracture displacement 290.19 10.06 100 75885 1168 46608909
Osteoarthritis 248.14 10.06 397 75588 61628 46548449
Pathological fracture 240.48 10.06 154 75831 7796 46602281
Completed suicide 196.16 10.06 10 75975 145910 46464167
Death 189.46 10.06 161 75824 335387 46274690
Jaw disorder 182.03 10.06 110 75875 5020 46605057
Osteonecrosis 180.34 10.06 216 75769 25528 46584549
Osteoporotic fracture 179.98 10.06 91 75894 2914 46607163
Bone disorder 179.42 10.06 191 75794 19842 46590235
Osteopenia 177.79 10.06 176 75809 16785 46593292
Foot fracture 170.62 10.06 184 75801 19398 46590679
Bedridden 160.07 10.06 127 75858 9032 46601045
Arthralgia 159.30 10.06 1076 74909 363527 46246550
Toxicity to various agents 151.24 10.06 78 75907 211688 46398389
Fracture nonunion 150.44 10.06 75 75910 2329 46607748
Fracture 143.90 10.06 155 75830 16316 46593761
Osteomyelitis 134.63 10.06 174 75811 22209 46587868
Fracture delayed union 124.64 10.06 64 75921 2118 46607959
Fall 123.14 10.06 936 75049 328161 46281916
Impaired healing 116.25 10.06 212 75773 36531 46573546
Nodule 116.01 10.06 135 75850 15470 46594607
Product dose omission issue 108.96 10.06 70 75915 168450 46441627
Mobility decreased 105.84 10.06 275 75710 60319 46549758
Atypical fracture 104.81 10.06 38 75947 520 46609557
Maternal exposure during pregnancy 100.46 10.06 22 75963 102527 46507550
Presbyacusis 98.80 10.06 60 75925 2762 46607315
Dental caries 98.35 10.06 102 75883 10277 46599800
Pleural fibrosis 97.81 10.06 65 75920 3504 46606573
Blood pressure systolic increased 94.76 10.06 169 75816 28618 46581459
Spinal fracture 92.07 10.06 119 75866 15186 46594891
Lower limb fracture 91.73 10.06 107 75878 12291 46597786
Intramedullary rod insertion 89.31 10.06 51 75934 2092 46607985
Anaemia postoperative 88.59 10.06 51 75934 2125 46607952
Exposure during pregnancy 87.99 10.06 33 75952 108179 46501898
Pleural thickening 87.85 10.06 54 75931 2541 46607536
Bone sequestrum 86.77 10.06 46 75939 1627 46608450
Periodontal disease 86.72 10.06 46 75939 1629 46608448
Gastrooesophageal reflux disease 86.43 10.06 292 75693 74052 46536025
Intentional overdose 85.51 10.06 5 75980 64939 46545138
Exostosis 85.14 10.06 94 75891 10169 46599908
Pelvic fracture 82.73 10.06 98 75887 11441 46598636
Neutropenia 82.73 10.06 67 75918 143137 46466940
Deafness neurosensory 82.16 10.06 64 75921 4430 46605647
Rheumatoid arthritis 81.30 10.06 668 75317 239547 46370530
Pain in extremity 79.48 10.06 704 75281 257976 46352101
Bone density decreased 76.92 10.06 87 75898 9665 46600412
Arthropathy 76.84 10.06 307 75678 84393 46525684
Immobile 76.50 10.06 62 75923 4544 46605533
Tooth extraction 75.46 10.06 88 75897 10105 46599972
Osteosclerosis 75.20 10.06 55 75930 3461 46606616
Blood magnesium increased 73.14 10.06 51 75934 2976 46607101
Drug abuse 72.31 10.06 9 75976 63399 46546678
Tooth disorder 70.61 10.06 132 75853 23171 46586906
Disease progression 67.55 10.06 32 75953 91268 46518809
Resorption bone increased 67.11 10.06 34 75951 1093 46608984
Foot deformity 66.14 10.06 102 75883 15323 46594754
Bone cyst 65.18 10.06 41 75944 2010 46608067
Febrile neutropenia 64.34 10.06 37 75948 94590 46515487
Cardiac arrest 63.41 10.06 34 75951 90365 46519712
Carpal tunnel syndrome 62.64 10.06 101 75884 15758 46594319
Periodontitis 62.45 10.06 49 75936 3427 46606650
Comminuted fracture 62.26 10.06 26 75959 529 46609548
Eosinophilic bronchitis 62.12 10.06 22 75963 280 46609797
Malignant neoplasm progression 61.44 10.06 15 75970 64911 46545166
Muscle fatigue 59.61 10.06 40 75945 2191 46607886
Epigastric discomfort 59.58 10.06 59 75926 5625 46604452
Tooth fracture 59.45 10.06 75 75910 9340 46600737
Deformity 57.68 10.06 65 75920 7192 46602885
Alanine aminotransferase abnormal 57.40 10.06 41 75944 2486 46607591
Dental fistula 57.33 10.06 25 75960 568 46609509
Acute kidney injury 56.36 10.06 196 75789 235659 46374418
Injection site pain 56.02 10.06 55 75930 107097 46502980
Bursitis 55.93 10.06 109 75876 19733 46590344
Loss of personal independence in daily activities 55.69 10.06 212 75773 56971 46553106
Dyspnoea 55.64 10.06 554 75431 514994 46095083
Spinal compression fracture 54.87 10.06 85 75900 12818 46597259
Spinal osteoarthritis 54.37 10.06 89 75896 14062 46596015
Gingivitis 54.13 10.06 64 75921 7456 46602621
Therapeutic product effect variable 53.98 10.06 29 75956 1054 46609023
Device failure 53.66 10.06 57 75928 5902 46604175
Groin pain 52.21 10.06 69 75916 8996 46601081
Diarrhoea 52.13 10.06 622 75363 558980 46051097
Osteogenesis imperfecta 50.93 10.06 20 75965 345 46609732
Oral herpes 50.43 10.06 103 75882 19287 46590790
Obstructive airways disorder 49.71 10.06 83 75902 13329 46596748
Open reduction of fracture 49.09 10.06 28 75957 1146 46608931
Red blood cell sedimentation rate abnormal 48.64 10.06 83 75902 13566 46596511
Purulent discharge 48.54 10.06 49 75936 4781 46605296
Gingival disorder 48.36 10.06 41 75944 3200 46606877
Arthritis 46.87 10.06 249 75736 77067 46533010
Rash 46.83 10.06 364 75621 356148 46253929
Cyst 46.35 10.06 76 75909 12024 46598053
Pruritus 46.20 10.06 220 75765 242132 46367945
Seizure 46.05 10.06 81 75904 122973 46487104
Jaw fracture 45.94 10.06 36 75949 2513 46607564
Pulmonary fibrosis 45.63 10.06 101 75884 19991 46590086
Bone loss 44.32 10.06 36 75949 2647 46607430
Bone erosion 44.12 10.06 65 75920 9378 46600699
Somnolence 43.78 10.06 121 75864 156400 46453677
Oral cavity fistula 43.63 10.06 22 75963 700 46609377
Ulna fracture 43.00 10.06 25 75960 1061 46609016
Overdose 43.00 10.06 62 75923 101917 46508160
Exostosis of jaw 42.55 10.06 26 75959 1210 46608867
Sinusitis fungal 42.34 10.06 23 75962 855 46609222
Loose tooth 42.29 10.06 38 75947 3206 46606871
Alopecia 42.20 10.06 130 75855 162284 46447793
Bone graft 41.92 10.06 23 75962 872 46609205
Oral infection 41.67 10.06 42 75943 4090 46605987
Bone formation decreased 41.42 10.06 12 75973 75 46610002
Drug interaction 41.30 10.06 180 75805 202914 46407163
Respiratory symptom 41.17 10.06 31 75954 2039 46608038
Bone fragmentation 40.02 10.06 21 75964 727 46609350
Thrombocytopenia 39.94 10.06 92 75893 126489 46483588
Suicidal ideation 39.83 10.06 21 75964 56361 46553716
Vomiting 39.56 10.06 510 75475 452284 46157793
Tooth infection 38.98 10.06 71 75914 12215 46597862
Wrong technique in product usage process 38.84 10.06 20 75965 54402 46555675
No adverse event 38.68 10.06 5 75980 34226 46575851
Bone pain 38.59 10.06 165 75820 46725 46563352
Fistula discharge 38.51 10.06 22 75963 903 46609174
Headache 38.47 10.06 548 75437 477804 46132273
Diverticulum 38.43 10.06 67 75918 11139 46598938
Blood potassium increased 38.20 10.06 85 75900 16882 46593195
Pain in jaw 37.96 10.06 143 75842 38229 46571848
Product use in unapproved indication 37.94 10.06 55 75930 90218 46519859
Intentional product misuse 37.25 10.06 15 75970 47113 46562964
Hiatus hernia 37.14 10.06 88 75897 18214 46591863
Psoriasis 37.02 10.06 44 75941 78560 46531517
Joint range of motion decreased 36.59 10.06 78 75907 15046 46595031
Salpingo-oophorectomy unilateral 36.51 10.06 16 75969 368 46609709
Blood pressure diastolic abnormal 36.39 10.06 48 75937 6246 46603831
Blood pressure diastolic decreased 36.38 10.06 75 75910 14136 46595941
Tooth abscess 36.33 10.06 70 75915 12563 46597514
Injection site erythema 35.76 10.06 41 75944 74386 46535691
Limb asymmetry 35.55 10.06 20 75965 797 46609280
Suicide attempt 35.33 10.06 23 75962 55013 46555064
Fatigue 35.22 10.06 740 75245 607957 46002120
Tendonitis 34.97 10.06 74 75911 14203 46595874
Dental necrosis 34.91 10.06 12 75973 139 46609938
Acute phase reaction 34.29 10.06 13 75972 203 46609874
Dehydration 33.90 10.06 139 75846 159401 46450676
Infection 33.69 10.06 349 75636 133243 46476834
Myalgia 33.17 10.06 326 75659 122762 46487315
Gingival ulceration 32.98 10.06 20 75965 918 46609159
Coma 32.80 10.06 28 75957 58321 46551756
Abortion spontaneous 32.73 10.06 15 75970 43631 46566446
Ill-defined disorder 32.60 10.06 107 75878 26720 46583357
Product quality issue 32.26 10.06 9 75976 35639 46574438
Systemic lupus erythematosus rash 32.07 10.06 22 75963 1250 46608827
Periprosthetic fracture 31.54 10.06 15 75970 419 46609658
Joint swelling 31.25 10.06 410 75575 165663 46444414
Vitamin D deficiency 31.17 10.06 61 75924 11073 46599004
Nasal polyps 31.03 10.06 27 75958 2183 46607894
Multiple sclerosis relapse 30.79 10.06 15 75970 42110 46567967
Malocclusion 30.77 10.06 10 75975 96 46609981
Metaphyseal corner fracture 30.56 10.06 8 75977 32 46610045
Lactic acidosis 29.88 10.06 9 75976 33900 46576177
Tooth loss 29.84 10.06 45 75940 6628 46603449
Fracture malunion 29.60 10.06 11 75974 162 46609915
Rotator cuff syndrome 29.49 10.06 61 75924 11522 46598555
Abscess jaw 29.45 10.06 22 75963 1430 46608647
Sepsis 29.20 10.06 118 75867 135896 46474181
Meniscus injury 29.06 10.06 42 75943 5954 46604123
Drug intolerance 28.91 10.06 366 75619 146683 46463394
Spinal disorder 28.86 10.06 49 75936 7975 46602102
Bursitis infective 28.83 10.06 20 75965 1157 46608920
Pulmonary arterial hypertension 28.79 10.06 4 75981 25924 46584153
Back pain 28.77 10.06 491 75494 209548 46400529
Tibia fracture 28.72 10.06 36 75949 4453 46605624
Toothache 28.63 10.06 75 75910 16517 46593560
Intentional self-injury 28.62 10.06 3 75982 24163 46585914
Femoral neck fracture 28.51 10.06 49 75936 8054 46602023
Skin lesion 28.48 10.06 102 75883 26611 46583466
Dry eye 28.35 10.06 111 75874 30211 46579866
Thoracic vertebral fracture 28.21 10.06 34 75951 4041 46606036
Neutrophilia 27.74 10.06 29 75956 2948 46607129
Pemphigus 27.62 10.06 20 75965 45254 46564823
Bronchiectasis 27.26 10.06 52 75933 9264 46600813
Temporomandibular joint syndrome 27.09 10.06 31 75954 3487 46606590
Anaphylactic reaction 26.90 10.06 28 75957 53084 46556993
Red blood cell sedimentation rate increased 26.66 10.06 90 75895 22799 46587278
Musculoskeletal stiffness 26.62 10.06 260 75725 97733 46512344
Respiratory arrest 26.34 10.06 11 75974 33805 46576272
Atrophy 25.99 10.06 21 75964 1532 46608545
Arteriovenous fistula occlusion 25.85 10.06 12 75973 317 46609760
Gingival swelling 25.79 10.06 32 75953 3918 46606159
Sputum increased 25.76 10.06 22 75963 1734 46608343
Chronic sinusitis 25.49 10.06 36 75949 4997 46605080
Therapy cessation 25.49 10.06 6 75979 26623 46583454
Glossodynia 25.30 10.06 21 75964 44352 46565725
Poor venous access 25.08 10.06 47 75938 8261 46601816
Blue toe syndrome 24.98 10.06 12 75973 343 46609734
Radius fracture 24.98 10.06 29 75956 3313 46606764
Tachycardia 24.97 10.06 81 75904 99541 46510536
Muscle strain 24.87 10.06 42 75943 6807 46603270
Bone marrow oedema 24.71 10.06 16 75969 825 46609252
Nausea 24.62 10.06 894 75091 686560 45923517
Tenosynovitis 24.57 10.06 44 75941 7471 46602606
Synovitis 24.57 10.06 177 75808 60898 46549179
Bradycardia 24.46 10.06 44 75941 66254 46543823
Hyperlipidaemia 24.39 10.06 76 75909 18463 46591614
Injection site swelling 24.36 10.06 18 75967 40309 46569768
Systemic lupus erythematosus 24.28 10.06 43 75942 65137 46544940
Blood pressure fluctuation 24.17 10.06 106 75879 30342 46579735
Diastolic dysfunction 24.11 10.06 36 75949 5256 46604821
Spinal stenosis 24.04 10.06 59 75926 12484 46597593
Confusional state 23.97 10.06 157 75828 159735 46450342
Lumbar vertebral fracture 23.77 10.06 33 75952 4509 46605568
Nail bed inflammation 23.74 10.06 12 75973 384 46609693
Inflammation 23.60 10.06 148 75837 48633 46561444
Rheumatoid nodule 23.55 10.06 48 75937 8972 46601105
Patellofemoral pain syndrome 23.27 10.06 13 75972 511 46609566
Osteonecrosis of external auditory canal 23.25 10.06 8 75977 93 46609984
Hyperkalaemia 23.22 10.06 29 75956 50680 46559397
Injection site pruritus 22.42 10.06 19 75966 39724 46570353
Vaginal haemorrhage 22.19 10.06 7 75978 25597 46584480
Spondylolisthesis 21.83 10.06 26 75959 3052 46607025
Calcium deficiency 21.77 10.06 15 75970 858 46609219
Hyperaesthesia teeth 21.72 10.06 19 75966 1547 46608530
Mucosal inflammation 21.54 10.06 19 75966 38957 46571120
Interstitial lung disease 21.49 10.06 156 75829 53793 46556284
Mastication disorder 21.46 10.06 21 75964 1973 46608104
Full blood count decreased 21.27 10.06 5 75980 22206 46587871
Drug withdrawal syndrome 21.18 10.06 9 75976 27375 46582702
Emphysema 21.11 10.06 46 75939 9008 46601069
Monoclonal gammopathy 21.10 10.06 13 75972 614 46609463
Hyperparathyroidism 21.07 10.06 23 75962 2456 46607621
Weight bearing difficulty 21.07 10.06 22 75963 2233 46607844
Eczema 20.99 10.06 77 75908 20323 46589754
Pregnancy 20.86 10.06 9 75976 27128 46582949
Embolism venous 20.86 10.06 23 75962 2484 46607593
Tremor 20.83 10.06 107 75878 115532 46494545
Humerus fracture 20.65 10.06 41 75944 7521 46602556
Polyp 20.64 10.06 33 75952 5110 46604967
Flushing 20.33 10.06 47 75938 64567 46545510
Neoplasm progression 20.27 10.06 9 75976 26674 46583403
Agitation 20.24 10.06 37 75948 55378 46554699
Off label use 20.09 10.06 468 75517 379373 46230704
Basal cell carcinoma 19.97 10.06 76 75909 20411 46589666
Oesophagitis 19.88 10.06 58 75927 13593 46596484
Respiratory failure 19.88 10.06 83 75902 94733 46515344
Type V hyperlipidaemia 19.86 10.06 11 75974 425 46609652
Hypercholesterolaemia 19.77 10.06 52 75933 11478 46598599
Feeling abnormal 19.66 10.06 121 75864 124939 46485138
Osteitis 19.52 10.06 25 75960 3160 46606917
Drug reaction with eosinophilia and systemic symptoms 19.44 10.06 12 75973 29536 46580541
Fluid overload 19.38 10.06 10 75975 27175 46582902
Pyrexia 19.22 10.06 427 75558 348375 46261702
Mesenteric panniculitis 19.21 10.06 6 75979 50 46610027
Premature delivery 19.19 10.06 6 75979 22063 46588014
Blood pressure increased 19.14 10.06 301 75684 126365 46483712
White blood cell count decreased 19.02 10.06 106 75879 112125 46497952
Fractured sacrum 18.99 10.06 19 75966 1834 46608243
Pneumonia 18.98 10.06 467 75518 375853 46234224
Vitamin B12 decreased 18.96 10.06 23 75962 2752 46607325
Wrist fracture 18.84 10.06 51 75934 11452 46598625
Gingival recession 18.60 10.06 16 75969 1274 46608803
Bone density abnormal 18.58 10.06 24 75961 3060 46607017
Large intestine polyp 18.39 10.06 40 75945 7821 46602256
Blood pressure diastolic increased 18.29 10.06 34 75951 5940 46604137
Skeletal injury 18.29 10.06 15 75970 1118 46608959
Peripheral vascular disorder 18.28 10.06 34 75951 5943 46604134
Walking aid user 18.18 10.06 30 75955 4770 46605307
Anaemia 18.10 10.06 300 75685 255479 46354598
Blood creatine phosphokinase MB 18.03 10.06 4 75981 6 46610071
Cerumen impaction 17.94 10.06 15 75970 1148 46608929
Red blood cell sedimentation rate 17.84 10.06 18 75967 1755 46608322
Injection site bruising 17.81 10.06 19 75966 35617 46574460
Purulence 17.58 10.06 17 75968 1574 46608503
Osteomyelitis chronic 17.58 10.06 10 75975 407 46609670
Urinary tract disorder 17.55 10.06 20 75965 2240 46607837
Withdrawal syndrome 17.52 10.06 4 75981 18130 46591947
Septic shock 17.51 10.06 43 75942 57850 46552227
Infusion related reaction 17.43 10.06 246 75739 100962 46509115
Bruxism 17.43 10.06 23 75962 2994 46607083
Cataract operation 17.40 10.06 27 75958 4076 46606001
Anal abscess 17.28 10.06 25 75960 3547 46606530
Eosinophil count increased 17.25 10.06 39 75946 7827 46602250
Fear of injection 17.18 10.06 27 75958 4120 46605957
Palmar-plantar erythrodysaesthesia syndrome 17.01 10.06 6 75979 20445 46589632
Polymyalgia rheumatica 16.97 10.06 20 75965 2322 46607755
Limb injury 16.97 10.06 69 75916 19105 46590972
Neutrophil count decreased 16.77 10.06 28 75957 43398 46566679
Rib fracture 16.61 10.06 68 75917 18886 46591191
Drug resistance 16.45 10.06 4 75981 17364 46592713
Ankle arthroplasty 16.37 10.06 11 75974 604 46609473
Mental disorder 16.36 10.06 8 75977 22417 46587660
Renal failure 16.28 10.06 113 75872 113481 46496596
Episcleral hyperaemia 16.27 10.06 3 75982 0 46610077
Cataract 16.22 10.06 128 75857 45287 46564790
Cardio-respiratory arrest 16.19 10.06 47 75938 59822 46550255
Abnormal behaviour 16.16 10.06 7 75978 21051 46589026
Female genital tract fistula 16.16 10.06 23 75962 3216 46606861
Leukopenia 16.14 10.06 57 75928 68286 46541791
Platelet count decreased 16.12 10.06 96 75889 99928 46510149
Gastroenteritis 16.05 10.06 80 75905 24139 46585938
Bone fissure 15.85 10.06 7 75978 164 46609913
Traumatic ulcer 15.77 10.06 5 75980 44 46610033
Hypersomnia 15.76 10.06 3 75982 15436 46594641
Acute respiratory distress syndrome 15.72 10.06 8 75977 21914 46588163
Edentulous 15.68 10.06 8 75977 261 46609816
Bone hypertrophy 15.57 10.06 9 75976 378 46609699
Barrett's oesophagus 15.40 10.06 11 75974 667 46609410
Blood pressure systolic abnormal 15.17 10.06 30 75955 5487 46604590
Scapula fracture 15.15 10.06 9 75976 398 46609679
Cellulitis 15.12 10.06 178 75807 70110 46539967
Blood cholinesterase increased 15.08 10.06 4 75981 17 46610060
Pseudarthrosis 15.00 10.06 9 75976 405 46609672
Scoliosis 14.99 10.06 32 75953 6178 46603899
Exposed bone in jaw 14.87 10.06 22 75963 3186 46606891
C-reactive protein increased 14.72 10.06 153 75832 58437 46551640
Lumbar spinal stenosis 14.71 10.06 26 75959 4369 46605708
Lethargy 14.71 10.06 39 75946 51132 46558945
Actinomycosis 14.69 10.06 13 75972 1075 46609002
Medical device removal 14.66 10.06 14 75971 1276 46608801
Syncope 14.66 10.06 105 75880 104698 46505379
Fluid retention 14.60 10.06 39 75946 51007 46559070
Intervertebral disc disorder 14.60 10.06 25 75960 4097 46605980
Sopor 14.58 10.06 7 75978 19821 46590256
Hypertonic bladder 14.50 10.06 21 75964 2983 46607094
Infrequent bowel movements 14.48 10.06 13 75972 1095 46608982
Multiple organ dysfunction syndrome 14.42 10.06 40 75945 51670 46558407
Actinic keratosis 14.40 10.06 18 75967 2221 46607856
Serotonin syndrome 14.39 10.06 11 75974 24209 46585868
Jaw cyst 14.28 10.06 6 75979 124 46609953
Neuritis 14.26 10.06 11 75974 750 46609327
Hysterectomy 14.20 10.06 36 75949 7770 46602307
Caecum operation 14.19 10.06 3 75982 3 46610074
Oral disorder 14.16 10.06 36 75949 7786 46602291
Pulmonary embolism 14.13 10.06 111 75874 108474 46501603
Necrotising ulcerative gingivostomatitis 14.09 10.06 4 75981 23 46610054
Granulomatosis with polyangiitis 14.08 10.06 16 75969 1786 46608291
Metabolic acidosis 14.07 10.06 26 75959 38754 46571323
Oesophageal stenosis 13.87 10.06 20 75965 2829 46607248
Nodal osteoarthritis 13.85 10.06 11 75974 783 46609294
Hypoxia 13.80 10.06 41 75944 51797 46558280
Cystocele 13.75 10.06 13 75972 1170 46608907
Gingival abscess 13.69 10.06 10 75975 628 46609449
Enchondromatosis 13.69 10.06 5 75980 70 46610007
Memory impairment 13.67 10.06 72 75913 77265 46532812
Skin ulcer 13.59 10.06 95 75890 32363 46577714
Hospitalisation 13.59 10.06 55 75930 63330 46546747
Scleritis 13.54 10.06 20 75965 2892 46607185
Osteomalacia 13.43 10.06 10 75975 647 46609430
Electrocardiogram QT prolonged 13.37 10.06 41 75944 51284 46558793
Epileptic encephalopathy 13.14 10.06 7 75978 250 46609827
Mood swings 13.13 10.06 5 75980 16247 46593830
Unresponsive to stimuli 13.12 10.06 20 75965 32154 46577923
Facet joint syndrome 13.11 10.06 13 75972 1241 46608836
Hip fracture 13.11 10.06 81 75904 26475 46583602
Gingival pain 13.10 10.06 30 75955 6073 46604004
Vaginal polyp 12.98 10.06 3 75982 6 46610071
Iron deficiency anaemia 12.98 10.06 59 75926 17147 46592930
Endodontic procedure 12.92 10.06 18 75967 2467 46607610
Oral discharge 12.77 10.06 6 75979 163 46609914
Bone atrophy 12.64 10.06 4 75981 35 46610042
Mass excision 12.56 10.06 7 75978 274 46609803
Renal cyst 12.55 10.06 37 75948 8722 46601355
Total lung capacity decreased 12.54 10.06 12 75973 1097 46608980
Immunoglobulins increased 12.51 10.06 7 75978 276 46609801
Disturbance in attention 12.51 10.06 20 75965 31540 46578537
Hepatic failure 12.48 10.06 22 75963 33394 46576683
Depressed level of consciousness 12.39 10.06 38 75947 47531 46562546
Gingivectomy 12.38 10.06 3 75982 8 46610069
Vascular skin disorder 12.38 10.06 3 75982 8 46610069
Dental plaque 12.34 10.06 5 75980 94 46609983
Lumbar radiculopathy 12.32 10.06 15 75970 1801 46608276
Cardiac failure congestive 12.31 10.06 93 75892 91657 46518420
Ankle fracture 12.31 10.06 54 75931 15457 46594620
Tachypnoea 12.30 10.06 4 75981 14347 46595730
Blood parathyroid hormone decreased 12.26 10.06 24 75961 4357 46605720
Hallucination 12.24 10.06 41 75944 49910 46560167
Heart rate decreased 12.21 10.06 91 75894 31632 46578445
Joint dislocation 12.17 10.06 43 75942 11143 46598934
Procedural pain 12.12 10.06 48 75937 13131 46596946
Atopy 12.07 10.06 6 75979 185 46609892
Angioedema 12.07 10.06 29 75956 39313 46570764
Caesarean section 12.00 10.06 6 75979 16597 46593480
Adjustment disorder 11.93 10.06 13 75972 1386 46608691
Hyperplastic cholecystopathy 11.92 10.06 5 75980 103 46609974
Gingival blister 11.90 10.06 4 75981 43 46610034
Electrophoresis protein abnormal 11.88 10.06 3 75982 10 46610067
Drug dependence 11.87 10.06 9 75976 19892 46590185
Uterine disorder 11.84 10.06 18 75967 2670 46607407
Irritability 11.80 10.06 18 75967 28928 46581149
Kyphoscoliosis 11.78 10.06 8 75977 447 46609630
Encephalopathy 11.76 10.06 23 75962 33566 46576511
Pulpitis dental 11.72 10.06 10 75975 787 46609290
Joint injury 11.72 10.06 62 75923 19147 46590930
Sedation 11.69 10.06 12 75973 22898 46587179
Sleep disorder 11.66 10.06 122 75863 46673 46563404
Peripheral sensorimotor neuropathy 11.59 10.06 12 75973 1206 46608871
Alveolar osteitis 11.57 10.06 7 75978 320 46609757
Nocturnal dyspnoea 11.55 10.06 11 75974 1000 46609077
Multiple fractures 11.54 10.06 27 75958 5540 46604537
Injection site warmth 11.52 10.06 4 75981 13768 46596309
Coagulopathy 11.51 10.06 8 75977 18491 46591586
Breast disorder 11.47 10.06 15 75970 1936 46608141
Bone resorption test abnormal 11.46 10.06 3 75982 12 46610065
Cerebral thrombosis 11.45 10.06 14 75971 1689 46608388
Neutropenic sepsis 11.36 10.06 3 75982 12321 46597756
Upper respiratory tract inflammation 11.31 10.06 18 75967 2777 46607300
Urticaria 11.29 10.06 130 75855 117762 46492315
Alveolar bone resorption 11.29 10.06 4 75981 51 46610026
Joint effusion 11.28 10.06 44 75941 11951 46598126
Vertigo 11.28 10.06 132 75853 51916 46558161
Sputum purulent 11.23 10.06 10 75975 834 46609243
Vasomotor rhinitis 11.15 10.06 4 75981 53 46610024
Diverticulum intestinal 11.14 10.06 28 75957 6013 46604064
Breast cyst 11.12 10.06 13 75972 1496 46608581
Vision blurred 11.07 10.06 80 75905 79628 46530449
Acute respiratory failure 11.05 10.06 19 75966 29119 46580958
Stevens-Johnson syndrome 11.01 10.06 13 75972 23284 46586793
Oedema peripheral 11.01 10.06 339 75646 159367 46450710
Device malfunction 10.99 10.06 4 75981 13370 46596707
Atrophic vulvovaginitis 10.99 10.06 13 75972 1515 46608562
Delirium 10.98 10.06 28 75957 37200 46572877
Mental status changes 10.97 10.06 29 75956 38059 46572018
Foot operation 10.97 10.06 24 75961 4713 46605364
Contraindicated product administered 10.96 10.06 187 75798 79760 46530317
Soft tissue inflammation 10.95 10.06 6 75979 227 46609850
Mouth ulceration 10.92 10.06 78 75907 26754 46583323
Hypercalcaemia 10.90 10.06 65 75920 20981 46589096
Vitreous detachment 10.88 10.06 14 75971 1777 46608300
Vertebral foraminal stenosis 10.78 10.06 10 75975 879 46609198
Emotional distress 10.78 10.06 21 75964 30686 46579391
Palatal ulcer 10.76 10.06 4 75981 59 46610018
Gingival discomfort 10.74 10.06 5 75980 133 46609944
Gastrointestinal disorder 10.73 10.06 146 75839 59430 46550647
Rash maculo-papular 10.73 10.06 18 75967 27856 46582221
Unevaluable event 10.58 10.06 39 75946 46136 46563941
Multiple drug therapy 10.57 10.06 10 75975 901 46609176
Hypertension 10.56 10.06 405 75580 195951 46414126
Pulmonary oedema 10.54 10.06 45 75940 51060 46559017
Bite 10.54 10.06 7 75978 377 46609700
Ulcer 10.52 10.06 56 75929 17336 46592741
Uterine dilation and curettage 10.51 10.06 10 75975 907 46609170
Urine calcium/creatinine ratio increased 10.50 10.06 5 75980 140 46609937
Hypothyroidism 10.47 10.06 87 75898 31251 46578826
Malpositioned teeth 10.46 10.06 3 75982 18 46610059
Urosepsis 10.43 10.06 6 75979 15347 46594730
Aggression 10.42 10.06 13 75972 22731 46587346
Hyperhidrosis 10.40 10.06 94 75891 89214 46520863
Pleurisy 10.38 10.06 32 75953 7730 46602347
Iliotibial band syndrome 10.34 10.06 5 75980 145 46609932
Symptom recurrence 10.34 10.06 7 75978 389 46609688
Colitis 10.33 10.06 29 75956 37318 46572759
Device breakage 10.32 10.06 37 75948 9655 46600422
Acquired porokeratosis 10.32 10.06 3 75982 19 46610058
Articular calcification 10.24 10.06 4 75981 68 46610009
Sacroiliitis 10.23 10.06 15 75970 2154 46607923
Carotid bruit 10.21 10.06 9 75976 740 46609337
Adrenal suppression 10.21 10.06 10 75975 941 46609136
Hyperpathia 10.19 10.06 3 75982 20 46610057
Gait disturbance 10.18 10.06 309 75676 144954 46465123
Status epilepticus 10.18 10.06 5 75980 13974 46596103
Urge incontinence 10.13 10.06 9 75976 748 46609329

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Atypical femur fracture 80.33 13.82 20 12066 311 29940081
Rheumatoid arthritis 75.49 13.82 88 11998 41109 29899283
Sleep disorder due to general medical condition, insomnia type 70.07 13.82 24 12062 1182 29939210
Impaired work ability 62.96 13.82 35 12051 5608 29934784
Therapy partial responder 61.61 13.82 30 12056 3661 29936731
Femur fracture 49.68 13.82 33 12053 7276 29933116
Blood pressure increased 49.26 13.82 97 11989 71831 29868561
Cystitis escherichia 48.05 13.82 12 12074 189 29940203
Lacrimal disorder 46.62 13.82 13 12073 319 29940073
Body temperature decreased 43.59 13.82 34 12052 9621 29930771
Blood pressure systolic increased 43.28 13.82 41 12045 15069 29925323
Breath sounds abnormal 40.27 13.82 25 12061 4910 29935482
Pain 37.33 13.82 153 11933 172488 29767904
Hernia pain 36.56 13.82 10 12076 228 29940164
Arthralgia 36.48 13.82 129 11957 135662 29804730
Toxicity to various agents 36.48 13.82 13 12073 177170 29763222
Nerve degeneration 34.86 13.82 9 12077 163 29940229
Hernia 33.72 13.82 28 12058 8658 29931734
Pemphigus 32.92 13.82 14 12072 1247 29939145
Pyelonephritis acute 32.90 13.82 15 12071 1578 29938814
Cataract 32.45 13.82 42 12044 21793 29918599
Infusion related reaction 31.82 13.82 58 12028 40506 29899886
Tibia fracture 31.47 13.82 14 12072 1391 29939001
Bone density decreased 31.33 13.82 15 12071 1763 29938629
Renal neoplasm 31.03 13.82 13 12073 1116 29939276
Henoch-Schonlein purpura 30.80 13.82 14 12072 1463 29938929
Oesophageal rupture 30.79 13.82 10 12076 417 29939975
Heart rate decreased 30.60 13.82 40 12046 20954 29919438
Stress 30.19 13.82 39 12047 20196 29920196
Death 30.13 13.82 62 12024 357221 29583171
Completed suicide 29.42 13.82 3 12083 99489 29840903
Blood pressure diastolic decreased 28.25 13.82 22 12064 6209 29934183
Respiratory rate increased 27.08 13.82 25 12061 8890 29931502
Ureteric stenosis 26.72 13.82 12 12074 1219 29939173
Fibula fracture 25.27 13.82 10 12076 741 29939651
Infection 25.23 13.82 79 12007 77995 29862397
Acute kidney injury 24.36 13.82 46 12040 273796 29666596
Mobility decreased 24.06 13.82 40 12046 25959 29914433
Osteonecrosis 23.91 13.82 31 12055 16104 29924288
Lung neoplasm malignant 23.89 13.82 30 12056 15102 29925290
Herpes zoster 23.71 13.82 43 12043 29900 29910492
Impaired healing 23.55 13.82 29 12057 14311 29926081
Spinal fracture 22.62 13.82 20 12066 6728 29933664
Arterial occlusive disease 22.18 13.82 16 12070 4024 29936368
Lymphocele 21.79 13.82 11 12075 1449 29938943
Osteoporosis 21.57 13.82 24 12062 10639 29929753
Stress fracture 20.68 13.82 9 12077 848 29939544
Osteonecrosis of jaw 20.48 13.82 31 12055 18587 29921805
Distal intestinal obstruction syndrome 20.18 13.82 7 12079 358 29940034
Blood pressure diastolic increased 20.07 13.82 13 12073 2745 29937647
Extraskeletal ossification 19.94 13.82 4 12082 21 29940371
Osteomyelitis 19.90 13.82 27 12059 14654 29925738
Musculoskeletal discomfort 19.79 13.82 18 12068 6282 29934110
Atypical fracture 19.72 13.82 5 12081 84 29940308
Epididymitis 19.56 13.82 12 12074 2307 29938085
Limb discomfort 19.40 13.82 21 12065 9029 29931363
Drug interaction 19.09 13.82 32 12054 199536 29740856
Wound 18.65 13.82 24 12062 12378 29928014
Fracture 18.55 13.82 17 12069 5989 29934403
Nasal neoplasm 18.36 13.82 5 12081 112 29940280
Middle ear effusion 17.91 13.82 7 12079 502 29939890
Dizziness postural 17.76 13.82 16 12070 5514 29934878
Blood pressure fluctuation 17.65 13.82 28 12058 17475 29922917
Pathological fracture 17.48 13.82 14 12072 4112 29936280
Abdominal rigidity 17.47 13.82 9 12077 1237 29939155
Intestinal prolapse 17.30 13.82 5 12081 140 29940252
Musculoskeletal stiffness 17.24 13.82 42 12044 35839 29904553
Sensory disturbance 17.08 13.82 16 12070 5795 29934597
Lower respiratory tract infection 17.02 13.82 35 12051 26679 29913713
Phlebosclerosis 16.97 13.82 5 12081 150 29940242
Oxygen saturation decreased 16.92 13.82 47 12039 43393 29896999
Wheezing 16.81 13.82 38 12048 30900 29909492
Product dose omission issue 16.76 13.82 8 12078 91623 29848769
Hypersensitivity vasculitis 16.56 13.82 13 12073 3710 29936682
Extranodal marginal zone B-cell lymphoma (MALT type) 16.29 13.82 5 12081 173 29940219
Lower respiratory tract congestion 16.20 13.82 8 12078 1005 29939387
Purpura 16.11 13.82 20 12066 9947 29930445
Fracture displacement 16.08 13.82 4 12082 62 29940330
Bronchial obstruction 16.04 13.82 9 12077 1467 29938925
Renal mass 15.88 13.82 9 12077 1495 29938897
Febrile neutropenia 15.76 13.82 12 12074 106681 29833711
Oral disorder 15.57 13.82 13 12073 4049 29936343
Rales 15.56 13.82 16 12070 6484 29933908
Thrombocytopenia 15.01 13.82 20 12066 137024 29803368
Nasopharyngitis 14.98 13.82 55 12031 58794 29881598
Genital lesion 14.60 13.82 5 12081 246 29940146
Skin cancer 14.55 13.82 17 12069 7944 29932448
Fall 14.54 13.82 124 11962 181748 29758644
Low turnover osteopathy 14.31 13.82 4 12082 99 29940293
Needle issue 14.14 13.82 12 12074 3820 29936572
Deafness 14.01 13.82 19 12067 10306 29930086
Product storage error 14.00 13.82 15 12071 6376 29934016

Pharmacologic Action:

SourceCodeDescription
ATC M05BA07 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates
ATC M05BB02 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB07 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
FDA CS M0006519 Diphosphonates
FDA EPC N0000175579 Bisphosphonate
MeSH PA D050071 Bone Density Conservation Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Osteitis deformans indication 2089002 DOID:5408
Osteoporosis indication 64859006 DOID:11476
Postmenopausal osteoporosis indication 102447009
Glucocorticoid Induced Osteoporosis indication
Prevention of Glucocorticoid-Induced Osteoporosis indication
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Bone pain contraindication 12584003
Constipation contraindication 14760008 DOID:2089
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Stricture of esophagus contraindication 63305008
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Muscle pain contraindication 68962001
Fracture of femur contraindication 71620000
Duodenitis contraindication 72007001 DOID:8643
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Bed-ridden contraindication 160685001
Osteolysis contraindication 203522001
Esophageal dysmotility contraindication 266434009 DOID:9192
Aseptic necrosis of bone of jaw contraindication 441809006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.35 acidic
pKa2 6.42 acidic
pKa3 7.4 acidic
pKa4 11.47 acidic
pKa5 12.45 acidic
pKa6 4.27 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Farnesyl pyrophosphate synthase Enzyme INHIBITOR Ki 9.44 CHEMBL CHEMBL
Farnesyl diphosphate synthase Enzyme IC50 7.13 CHEMBL
Farnesyl diphosphate synthase Unclassified IC50 7.57 CHEMBL
Farnesyl pyrophosphate synthase Enzyme Ki 7.77 CHEMBL

External reference:

IDSource
D00942 KEGG_DRUG
115436-72-1 SECONDARY_CAS_RN
4021112 VANDF
4024121 VANDF
C1996201 UMLSCUI
CHEBI:8869 CHEBI
RIS PDB_CHEM_ID
CHEMBL923 ChEMBL_ID
CHEMBL1654 ChEMBL_ID
4194514 PUBCHEM_CID
D000068296 MESH_DESCRIPTOR_UI
DB00884 DRUGBANK_ID
3176 IUPHAR_LIGAND_ID
6522 INN_ID
OFG5EXG60L UNII
1356127 RXNORM
107688 MMSL
11659 MMSL
5428 MMSL
d04300 MMSL
007620 NDDF
007621 NDDF
387064005 SNOMEDCT_US
387582001 SNOMEDCT_US
734872006 SNOMEDCT_US
768538005 SNOMEDCT_US
768539002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-3098 TABLET, FILM COATED 35 mg ORAL ANDA 27 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-3099 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-3100 TABLET, FILM COATED 30 mg ORAL ANDA 27 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7771 TABLET, FILM COATED 150 mg ORAL ANDA 27 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1426 TABLET, DELAYED RELEASE 35 mg ORAL ANDA 30 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0470 TABLET, FILM COATED 25.80 mg ORAL NDA 27 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0470 TABLET, FILM COATED 4.20 mg ORAL NDA 27 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0471 TABLET, FILM COATED 0.70 mg ORAL NDA 27 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0471 TABLET, FILM COATED 4.30 mg ORAL NDA 27 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0472 TABLET, FILM COATED 4.90 mg ORAL NDA 27 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0472 TABLET, FILM COATED 30.10 mg ORAL NDA 27 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0477 TABLET, FILM COATED 64.50 mg ORAL NDA 27 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0477 TABLET, FILM COATED 10.50 mg ORAL NDA 27 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0478 TABLET, FILM COATED 21 mg ORAL NDA 27 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0478 TABLET, FILM COATED 129 mg ORAL NDA 27 sections
Atelvia HUMAN PRESCRIPTION DRUG LABEL 2 0430-0979 TABLET, DELAYED RELEASE 4.90 mg ORAL NDA 28 sections
Atelvia HUMAN PRESCRIPTION DRUG LABEL 2 0430-0979 TABLET, DELAYED RELEASE 30.10 mg ORAL NDA 28 sections
risedronate sodium HUMAN PRESCRIPTION DRUG LABEL 2 0591-2044 TABLET, FILM COATED 129 mg ORAL NDA AUTHORIZED GENERIC 26 sections
risedronate sodium HUMAN PRESCRIPTION DRUG LABEL 2 0591-2044 TABLET, FILM COATED 21 mg ORAL NDA AUTHORIZED GENERIC 26 sections
risedronate sodium HUMAN PRESCRIPTION DRUG LABEL 2 0591-2067 TABLET, FILM COATED 64.50 mg ORAL NDA AUTHORIZED GENERIC 26 sections
risedronate sodium HUMAN PRESCRIPTION DRUG LABEL 2 0591-2067 TABLET, FILM COATED 10.50 mg ORAL NDA AUTHORIZED GENERIC 26 sections
risedronate sodium HUMAN PRESCRIPTION DRUG LABEL 2 0591-2075 TABLET, FILM COATED 4.90 mg ORAL NDA AUTHORIZED GENERIC 26 sections
risedronate sodium HUMAN PRESCRIPTION DRUG LABEL 2 0591-2075 TABLET, FILM COATED 30.10 mg ORAL NDA AUTHORIZED GENERIC 26 sections
risedronate sodium HUMAN PRESCRIPTION DRUG LABEL 2 0591-2102 TABLET, FILM COATED 4.30 mg ORAL NDA AUTHORIZED GENERIC 26 sections
risedronate sodium HUMAN PRESCRIPTION DRUG LABEL 2 0591-2102 TABLET, FILM COATED 0.70 mg ORAL NDA AUTHORIZED GENERIC 26 sections
risedronate sodium HUMAN PRESCRIPTION DRUG LABEL 2 0591-2109 TABLET, FILM COATED 25.80 mg ORAL NDA AUTHORIZED GENERIC 26 sections
risedronate sodium HUMAN PRESCRIPTION DRUG LABEL 2 0591-2109 TABLET, FILM COATED 4.20 mg ORAL NDA AUTHORIZED GENERIC 26 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16714-870 TABLET, DELAYED RELEASE 35 mg ORAL ANDA 27 sections
Risedronate Sodium Human Prescription Drug Label 1 33342-107 TABLET, FILM COATED 5 mg ORAL ANDA 27 sections
Risedronate Sodium Human Prescription Drug Label 1 33342-108 TABLET, FILM COATED 30 mg ORAL ANDA 27 sections