levonorgestrel 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
steroids, progestogens 1572 797-63-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levonorgestrel
  • 18-Methylnorethindrone
  • D-Norgestrel
  • dexnorgestrel
  • norgestrel
A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.
  • Molecular weight: 312.45
  • Formula: C21H28O2
  • CLOGP: 3.32
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -4.73
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 52 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.03 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 94 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.50 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.03 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.40 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.470 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.372 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 67.298 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 35.237 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 5.780 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 7.280 % High 1
herg hERG pIC50 4.888 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 4.560 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 41.115 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 4.090 % High 1
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,JAK3,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK 18
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.773 High 1
mh-clint Mouse hepatocyte intrinsic clearance 95.280 High 1
mppb Mouse plasma protein binding (% unbound) 6 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.328 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 7.410 % High 1
rh-clint Rat hepatocyte intrinsic clearance 98.855 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 29.660 % High 1
rppb Rat plasma protein binding (% unbound) 4.580 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 37.068 uM High 1

Approvals:

DateAgencyCompanyOrphan
April 16, 1968 FDA WYETH PHARMS
July 2, 2018 PMDA Nobelpharma Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Device expulsion 149126.00 22.50 29799 148705 11087 90438856
Device dislocation 52371.04 22.50 12134 166370 19348 90430595
Genital haemorrhage 26169.34 22.50 5470 173034 3232 90446711
Uterine perforation 17446.13 22.50 3823 174681 3731 90446212
Complication of device insertion 16137.47 22.50 3808 174696 6628 90443315
Pregnancy with contraceptive device 15896.36 22.50 3302 175202 1764 90448179
Procedural pain 13150.64 22.50 4146 174358 29214 90420729
Abdominal pain lower 12119.59 22.50 3805 174699 26372 90423571
Embedded device 9512.94 22.50 2098 176406 2150 90447793
Pelvic pain 8235.42 22.50 2421 176083 12936 90437007
Device breakage 7781.25 22.50 2271 176233 11773 90438170
Vaginal haemorrhage 7448.30 22.50 2663 175841 28608 90421335
Complication associated with device 6411.02 22.50 2113 176391 17336 90432607
Complication of device removal 6166.88 22.50 1592 176912 4663 90445280
Device difficult to use 5775.84 22.50 1904 176600 15621 90434322
Ectopic pregnancy with contraceptive device 5668.84 22.50 1136 177368 316 90449627
Device use issue 5555.69 22.50 1321 177183 2392 90447551
Heavy menstrual bleeding 4861.82 22.50 1742 176762 18788 90431155
Post procedural discomfort 4651.99 22.50 951 177553 390 90449553
Medical device discomfort 4554.74 22.50 1014 177490 1122 90448821
Device issue 3754.41 22.50 1596 176908 27941 90422002
Uterine rupture 3715.32 22.50 771 177733 398 90449545
Medical device pain 3414.70 22.50 756 177748 796 90449147
Amenorrhoea 3296.87 22.50 1131 177373 10591 90439352
Dyspareunia 2817.75 22.50 724 177780 2062 90447881
Expired device used 2751.50 22.50 561 177943 219 90449724
Unintentional medical device removal 2303.44 22.50 761 177743 6269 90443674
Post procedural haemorrhage 2273.34 22.50 797 177707 8001 90441942
Emotional distress 2034.02 22.50 1123 177381 35539 90414404
Uterine spasm 1992.49 22.50 435 178069 402 90449541
Intermenstrual bleeding 1934.21 22.50 716 177788 8507 90441436
Device deployment issue 1817.47 22.50 583 177921 4326 90445617
Procedural haemorrhage 1544.26 22.50 463 178041 2661 90447282
Loss of libido 1508.93 22.50 381 178123 986 90448957
Uterine cervix stenosis 1508.69 22.50 302 178202 81 90449862
Abdominal pain 1506.33 22.50 2749 175755 392972 90056971
Ovarian cyst 1444.35 22.50 698 177806 16620 90433323
Haemorrhage in pregnancy 1399.43 22.50 396 178108 1789 90448154
Injury 1362.47 22.50 1806 176698 195543 90254400
Menstruation irregular 1338.90 22.50 528 177976 7532 90442411
Ruptured ectopic pregnancy 1324.88 22.50 288 178216 255 90449688
Off label use of device 1312.48 22.50 274 178230 153 90449790
Dysmenorrhoea 1259.76 22.50 437 178067 4235 90445708
Device physical property issue 1220.61 22.50 376 178128 2400 90447543
Diarrhoea 1192.72 22.50 209 178295 938981 89510962
Uterine haemorrhage 1052.02 22.50 384 178120 4368 90445575
Coital bleeding 1050.93 22.50 248 178256 425 90449518
Pneumonia 1030.58 22.50 56 178448 638003 89811940
Intentional device misuse 1027.58 22.50 256 178248 614 90449329
Contraindicated device used 973.23 22.50 186 178318 0 90449943
Medical device monitoring error 915.67 22.50 175 178329 0 90449943
Dyspnoea 898.71 22.50 309 178195 880646 89569297
Uterine leiomyoma 885.08 22.50 431 178073 10433 90439510
Pelvic inflammatory disease 881.95 22.50 266 178238 1564 90448379
Ectopic pregnancy 850.10 22.50 297 178207 2944 90446999
Vaginal discharge 835.91 22.50 505 177999 18959 90430984
Device placement issue 812.96 22.50 256 178248 1774 90448169
Death 779.72 22.50 27 178477 456524 89993419
Acne 773.34 22.50 555 177949 27952 90421991
Joint swelling 765.47 22.50 60 178444 503240 89946703
Infusion related reaction 735.95 22.50 18 178486 416762 90033181
Drug intolerance 729.27 22.50 37 178467 447554 90002389
Internal injury 719.60 22.50 161 178343 185 90449758
Drug hypersensitivity 711.35 22.50 53 178451 463556 89986387
Hypomenorrhoea 700.66 22.50 178 178326 476 90449467
Breast cancer female 664.54 22.50 396 178108 14490 90435453
Fall 663.42 22.50 84 178420 481726 89968217
Arthropathy 645.82 22.50 16 178488 366226 90083717
Condition aggravated 645.37 22.50 187 178317 595358 89854585
Abortion spontaneous 642.30 22.50 655 177849 53401 90396542
Pemphigus 625.85 22.50 3 178501 326861 90123082
Rash 625.42 22.50 400 178104 795700 89654243
Idiopathic intracranial hypertension 624.33 22.50 243 178261 3338 90446605
Glossodynia 610.64 22.50 4 178500 321775 90128168
Off label use 604.25 22.50 774 177730 1101478 89348465
Anxiety 601.69 22.50 1647 176857 308125 90141818
Depression 601.62 22.50 1616 176888 298985 90150958
Libido decreased 597.64 22.50 224 178280 2758 90447185
Nasopharyngitis 595.70 22.50 57 178447 407047 90042896
Systemic lupus erythematosus 592.26 22.50 29 178475 361867 90088076
Abnormal uterine bleeding 588.34 22.50 200 178304 1812 90448131
Confusional state 584.26 22.50 47 178457 386158 90063785
Intra-uterine contraceptive device removal 576.45 22.50 112 178392 10 90449933
Hepatic enzyme increased 556.69 22.50 40 178464 360696 90089247
Wound 555.23 22.50 8 178496 302972 90146971
Rheumatoid arthritis 551.65 22.50 43 178461 362571 90087372
Uterine pain 545.72 22.50 131 178373 251 90449692
Swelling 539.69 22.50 89 178415 418969 90030974
Peripheral swelling 535.89 22.50 86 178418 413020 90036923
Menstrual disorder 534.73 22.50 255 178249 5883 90444060
Breast tenderness 526.36 22.50 197 178307 2415 90447528
Acute kidney injury 526.36 22.50 25 178479 320362 90129581
Infertility female 525.81 22.50 140 178364 477 90449466
Stomatitis 518.23 22.50 4 178500 274694 90175249
Treatment failure 515.01 22.50 19 178485 303909 90146034
Toxicity to various agents 513.45 22.50 11 178493 287835 90162108
Arthralgia 510.81 22.50 470 178034 778052 89671891
Contraindicated product administered 510.20 22.50 30 178474 320109 90129834
Pericarditis 509.32 22.50 4 178500 270147 90179796
Mood swings 507.06 22.50 379 178125 20323 90429620
Hypersensitivity 493.63 22.50 142 178362 454535 89995408
Vomiting 492.64 22.50 497 178007 787796 89662147
Fatigue 480.07 22.50 972 177532 1153051 89296892
Device use error 478.17 22.50 249 178255 6972 90442971
Therapeutic product effect decreased 475 22.50 16 178488 277555 90172388
Hypertension 469.63 22.50 158 178346 457374 89992569
Menometrorrhagia 468.38 22.50 150 178354 1105 90448838
Sinusitis 464.33 22.50 63 178441 343025 90106918
Cervical dysplasia 462.90 22.50 203 178301 3831 90446112
Pyrexia 445.85 22.50 388 178116 660097 89789846
Lower respiratory tract infection 441.51 22.50 11 178493 250648 90199295
Impaired healing 438.88 22.50 4 178500 234195 90215748
Haemoperitoneum 435.74 22.50 187 178317 3341 90446602
Wheezing 428.96 22.50 8 178496 238072 90211871
Menstruation delayed 425.76 22.50 160 178344 1985 90447958
Breast pain 418.36 22.50 259 178245 10159 90439784
Decreased appetite 415.27 22.50 114 178390 376426 90073517
Cough 397.08 22.50 117 178387 368845 90081098
Musculoskeletal stiffness 388.29 22.50 60 178444 296472 90153471
Device defective 385.72 22.50 171 178333 3315 90446628
Hypotension 381.03 22.50 87 178417 325310 90124633
Blister 380.02 22.50 33 178471 254965 90194978
Mobility decreased 369.47 22.50 34 178470 250700 90199243
Neutropenia 367.83 22.50 18 178486 224886 90225057
Psoriatic arthropathy 364.90 22.50 21 178483 228314 90221629
Folliculitis 363.59 22.50 8 178496 204345 90245598
Meningioma 356.35 22.50 182 178322 4889 90445054
Malaise 352.58 22.50 381 178123 585605 89864338
Abdominal discomfort 349.85 22.50 258 178246 477070 89972873
Contusion 347.33 22.50 43 178461 251173 90198770
Vaginal odour 343.91 22.50 99 178405 481 90449462
Asthenia 342.72 22.50 328 178176 533423 89916520
Ill-defined disorder 342.48 22.50 4 178500 184887 90265056
Blood cholesterol increased 342.26 22.50 16 178488 207996 90241947
Type 2 diabetes mellitus 339.79 22.50 14 178490 203230 90246713
Irritable bowel syndrome 337.97 22.50 17 178487 207431 90242512
Pruritus 335.94 22.50 343 178161 541182 89908761
Osteoarthritis 332.27 22.50 12 178492 195718 90254225
Intra-abdominal haemorrhage 331.74 22.50 142 178362 2520 90447423
Anaemia 331.46 22.50 140 178364 352662 90097281
Product dose omission issue 329.68 22.50 84 178420 291603 90158340
Pain in extremity 323.09 22.50 249 178255 450280 89999663
Nausea 322.70 22.50 1117 177387 1109199 89340744
Scar 320.59 22.50 256 178248 15139 90434804
Therapeutic product effect incomplete 318.72 22.50 15 178489 193881 90256062
Intentional product use issue 312.71 22.50 32 178472 216860 90233083
Pelvic discomfort 310.40 22.50 97 178407 653 90449290
Liver injury 302.16 22.50 7 178497 170560 90279383
Gastrointestinal disorder 301.69 22.50 68 178436 256619 90193324
Thrombocytopenia 300.38 22.50 31 178473 208694 90241249
Product use issue 298.73 22.50 138 178366 329781 90120162
Febrile neutropenia 290.73 22.50 4 178500 158345 90291598
Fear 289.06 22.50 249 178255 16373 90433570
Asthma 288.95 22.50 62 178442 242098 90207845
Fibromyalgia 288.32 22.50 34 178470 206235 90243708
Dry mouth 282.03 22.50 21 178483 184038 90265905
Maternal exposure during pregnancy 281.80 22.50 181 178323 359882 90090061
Weight decreased 281.29 22.50 203 178301 379707 90070236
Gait disturbance 281.24 22.50 82 178422 260414 90189529
Salpingectomy 279.13 22.50 78 178426 333 90449610
Presyncope 276.21 22.50 327 178177 31478 90418465
Device failure 273.22 22.50 170 178334 6727 90443216
Oedema 272.68 22.50 36 178468 200259 90249684
Dehydration 264.58 22.50 35 178469 194412 90255531
Product use in unapproved indication 263.13 22.50 169 178335 336067 90113876
Polymenorrhoea 260.70 22.50 100 178404 1317 90448626
Chlamydial infection 259.44 22.50 72 178432 298 90449645
Anhedonia 259.43 22.50 200 178304 11231 90438712
Premenstrual syndrome 258.52 22.50 86 178418 724 90449219
Intentional medical device removal by patient 256.02 22.50 60 178444 98 90449845
White blood cell count decreased 253.40 22.50 20 178484 167089 90282854
Lung disorder 251.59 22.50 10 178494 149873 90300070
Depressed mood 251.08 22.50 395 178109 49827 90400116
C-reactive protein increased 248.36 22.50 32 178472 181357 90268586
Drug interaction 248.11 22.50 117 178387 276336 90173607
Overdose 247.42 22.50 16 178488 157693 90292250
Arthritis 245.58 22.50 23 178481 167292 90282651
Uterine scar 245.22 22.50 51 178453 27 90449916
Mood altered 245.15 22.50 230 178274 16914 90433029
Adnexa uteri pain 243.92 22.50 73 178431 416 90449527
Bursitis 243.12 22.50 3 178501 131651 90318292
Constipation 239.11 22.50 127 178377 280268 90169675
Bacterial vulvovaginitis 236.64 22.50 82 178422 791 90449152
Joint range of motion decreased 231.29 22.50 8 178496 135635 90314308
Chest pain 231.11 22.50 175 178329 319470 90130473
Disease progression 228.61 22.50 22 178482 156593 90293350
Completed suicide 226.71 22.50 15 178489 145043 90304900
Loop electrosurgical excision procedure 224.60 22.50 44 178460 6 90449937
Hyponatraemia 223.83 22.50 9 178495 133529 90316414
Vaginal infection 223.52 22.50 162 178342 8278 90441665
Erythema 219.99 22.50 88 178416 229158 90220785
Inflammation 218.65 22.50 43 178461 178549 90271394
Endometritis 218.32 22.50 84 178420 1116 90448827
Neuropathy peripheral 217.54 22.50 13 178491 136957 90312986
Muscular weakness 215.91 22.50 69 178435 206597 90243346
Salpingitis 215.80 22.50 61 178443 274 90449669
Suppressed lactation 215.59 22.50 66 178438 411 90449532
Procedural dizziness 214.43 22.50 51 178453 92 90449851
Abortion of ectopic pregnancy 214.34 22.50 45 178459 27 90449916
Somnolence 212.84 22.50 73 178431 209011 90240932
Retained products of conception 212.69 22.50 51 178453 97 90449846
Device malfunction 211.46 22.50 233 178271 20744 90429199
Atrial fibrillation 211.24 22.50 13 178491 133598 90316345
Oedema peripheral 210.96 22.50 123 178381 257792 90192151
Hypokalaemia 209.59 22.50 12 178492 131104 90318839
Pancytopenia 208.97 22.50 6 178498 120257 90329686
Device intolerance 208.38 22.50 46 178458 47 90449896
Renal failure 206.36 22.50 13 178491 130994 90318949
Progesterone receptor assay positive 205.71 22.50 60 178444 308 90449635
Smear cervix abnormal 204.18 22.50 107 178397 3035 90446908
Dyspepsia 203.77 22.50 68 178436 198092 90251851
Breast cancer 202.77 22.50 373 178131 53388 90396555
Injection site pain 202.07 22.50 47 178457 173652 90276291
Endometriosis 200.70 22.50 135 178369 6113 90443830
Bronchitis 199.93 22.50 31 178473 152896 90297047
Bacterial vaginosis 198.33 22.50 86 178418 1577 90448366
Malignant neoplasm progression 194.86 22.50 3 178501 106867 90343076
Gait inability 193.03 22.50 29 178475 146427 90303516
Therapy non-responder 192.33 22.50 22 178482 136682 90313261
Platelet count decreased 187.88 22.50 24 178480 136945 90312998
Uterine cervical pain 187.66 22.50 38 178466 13 90449930
Delirium 185.90 22.50 4 178500 104355 90345588
Vulvovaginal pain 185.88 22.50 104 178400 3370 90446573
Tubo-ovarian abscess 181.98 22.50 57 178447 387 90449556
Irritability 181.73 22.50 283 178221 35379 90414564
Oxygen saturation decreased 180.95 22.50 7 178497 107476 90342467
Wound infection 178.89 22.50 7 178497 106395 90343548
Prescribed overdose 176.90 22.50 3 178501 97622 90352321
Gastrooesophageal reflux disease 176.48 22.50 54 178450 166283 90283660
Actinomyces test positive 175.84 22.50 36 178468 15 90449928
Cardiac failure 175.07 22.50 10 178494 109486 90340457
Cardiac failure congestive 174.96 22.50 4 178500 98690 90351253
Musculoskeletal pain 173.92 22.50 60 178444 171191 90278752
Pleural effusion 170.89 22.50 13 178491 111978 90337965
Hypertrichosis 168.31 22.50 74 178430 1405 90448538
Hydrometra 168.01 22.50 37 178467 37 90449906
Patient-device incompatibility 166.61 22.50 46 178458 186 90449757
Haemorrhagic ovarian cyst 165.56 22.50 60 178444 667 90449276
Hormone level abnormal 164.67 22.50 90 178414 2783 90447160
Liver disorder 164.52 22.50 22 178482 121247 90328696
Respiratory failure 164.24 22.50 20 178484 118398 90331545
Gastrointestinal haemorrhage 162.60 22.50 3 178501 90245 90359698
Vulvovaginal discomfort 161.58 22.50 87 178417 2610 90447333
Product shape issue 159.97 22.50 38 178466 68 90449875
Memory impairment 159.94 22.50 95 178409 197149 90252794
Ovarian cyst ruptured 159.92 22.50 71 178433 1381 90448562
Panic attack 158.38 22.50 226 178278 26139 90423804
Psychological trauma 158.20 22.50 69 178435 1284 90448659
Uterine polyp 157.35 22.50 84 178420 2476 90447467
Sciatica 156.90 22.50 11 178493 101371 90348572
Osteoporosis 156.88 22.50 8 178496 96523 90353420
Upper respiratory tract infection 156.83 22.50 31 178473 128287 90321656
Pelvic infection 155.04 22.50 48 178456 312 90449631
Uterine infection 154.54 22.50 52 178452 455 90449488
Pelvic adhesions 154.30 22.50 47 178457 287 90449656
COVID-19 153.67 22.50 70 178434 168773 90281170
Influenza 153.63 22.50 42 178462 139222 90310721
Renal impairment 153.33 22.50 15 178489 105406 90344537
Insomnia 152.63 22.50 264 178240 333210 90116733
Diffuse alopecia 151.76 22.50 65 178439 1155 90448788
Blood pressure increased 151.63 22.50 101 178403 197116 90252827
Peripheral venous disease 150.34 22.50 3 178501 83918 90366025
Cardiac arrest 149.85 22.50 16 178488 104919 90345024
Lower limb fracture 148.58 22.50 4 178500 85009 90364934
Uterine adhesions 148.44 22.50 32 178472 26 90449917
Pain 148.31 22.50 2768 175736 993573 89456370
Hospitalisation 148.31 22.50 35 178469 128065 90321878
Pelvic fluid collection 147.01 22.50 61 178443 998 90448945
Blood creatinine increased 145.96 22.50 15 178489 101371 90348572
Peritoneal adhesions 145.40 22.50 42 178462 207 90449736
Oestrogen receptor assay positive 143.41 22.50 50 178454 492 90449451
Abdominal pain upper 142.76 22.50 274 178230 332400 90117543
Sepsis 142.44 22.50 89 178415 179725 90270218
Procedural anxiety 141.86 22.50 56 178448 800 90449143
Haemoglobin decreased 141.49 22.50 71 178433 161885 90288058
Breast cancer stage III 140.47 22.50 6 178498 84441 90365502
Intentional overdose 140.09 22.50 12 178492 93822 90356121
Obesity 138.77 22.50 21 178483 105486 90344457
Road traffic accident 138 22.50 23 178481 107603 90342340
General physical health deterioration 135.19 22.50 313 178191 354802 90095141
Medical device site discomfort 134.11 22.50 42 178462 285 90449658
Procedural nausea 133.77 22.50 59 178445 1129 90448814
Herpes zoster 133.70 22.50 15 178489 94629 90355314
Drug abuse 133.26 22.50 7 178497 82340 90367603
Leukopenia 132.56 22.50 20 178484 100690 90349253
Hypoaesthesia 132.03 22.50 262 178242 313948 90135995
Gynaecological chlamydia infection 131.36 22.50 27 178477 12 90449931
Medical device entrapment 130.80 22.50 25 178479 0 90449943
Hirsutism 130.78 22.50 65 178439 1645 90448298
Red blood cell sedimentation rate increased 130.65 22.50 8 178496 82587 90367356
Psoriasis 130.24 22.50 64 178440 147690 90302253
Procedural vomiting 128.48 22.50 51 178453 740 90449203
Interstitial lung disease 125.22 22.50 6 178498 76399 90373544
Inappropriate schedule of product administration 123.25 22.50 71 178433 149862 90300081
Procedural complication 122.92 22.50 98 178406 5780 90444163
Blood glucose increased 122.91 22.50 20 178484 95226 90354717
Abortion missed 121.72 22.50 65 178439 1917 90448026
Dysphagia 121.72 22.50 35 178469 112243 90337700
Live birth 121.21 22.50 9 178495 79098 90370845
Hypoxia 120.90 22.50 5 178499 72394 90377549
Urinary tract infection 119.87 22.50 265 178239 305367 90144576
Drug-induced liver injury 118.73 22.50 18 178486 90300 90359643
Depressed level of consciousness 118.37 22.50 6 178498 72778 90377165
Cellulitis 118.26 22.50 19 178485 91318 90358625
Hepatic adenoma 118.09 22.50 41 178463 398 90449545
Oropharyngeal pain 117.55 22.50 40 178464 115147 90334796
Productive cough 117.42 22.50 9 178495 77054 90372889
Urticaria 117.12 22.50 278 178226 312456 90137487
Haematosalpinx 116.66 22.50 23 178481 4 90449939
Prescribed underdose 116.49 22.50 8 178496 75011 90374932
Cervix injury 115.10 22.50 22 178482 0 90449943
Uterine injury 114.36 22.50 26 178478 34 90449909
Loss of personal independence in daily activities 113.96 22.50 63 178441 136042 90313901
Cervical polyp 113.87 22.50 37 178467 287 90449656
Liver function test increased 113.66 22.50 16 178488 84839 90365104
Sleep disorder 113.06 22.50 134 178370 197896 90252047
Neutrophil count decreased 112.93 22.50 7 178497 71525 90378418
Cervicitis 111.39 22.50 42 178462 526 90449417
Uterine enlargement 111.34 22.50 54 178450 1294 90448649
Injection site erythema 109.97 22.50 29 178475 98473 90351470
Coma 109.21 22.50 9 178495 72623 90377320
Therapeutic response decreased 108.96 22.50 22 178482 89707 90360236
Device ineffective 108.65 22.50 34 178470 230 90449713
Dizziness 108.32 22.50 698 177806 588586 89861357
Cataract 108.22 22.50 9 178495 72083 90377860
Papilloedema 107.47 22.50 82 178422 4533 90445410
Pregnancy with implant contraceptive 106.04 22.50 75 178429 3686 90446257
Endometrial hyperplasia 105.03 22.50 47 178457 932 90449011
Injection site reaction 104.93 22.50 26 178478 92054 90357889
Intentional product misuse 104.67 22.50 24 178480 89580 90360363
Endometrial cancer 104.10 22.50 73 178431 3539 90446404
Joint stiffness 103.86 22.50 15 178489 78027 90371916
Hepatic cirrhosis 103.55 22.50 5 178499 63248 90386695
Nail disorder 102.40 22.50 3 178501 59064 90390879
Autoimmune disorder 101.56 22.50 15 178489 76729 90373214
Endometrial thickening 101.37 22.50 39 178465 518 90449425
Multiple organ dysfunction syndrome 101.30 22.50 9 178495 68327 90381616
Hyperkalaemia 100.66 22.50 7 178497 64957 90384986
Cervix disorder 100.56 22.50 41 178463 640 90449303
Rhinorrhoea 100.51 22.50 25 178479 88291 90361652
Mucosal inflammation 99.63 22.50 3 178501 57622 90392321
Focal nodular hyperplasia 98.91 22.50 42 178462 730 90449213
Cardio-respiratory arrest 97.26 22.50 7 178497 63133 90386810
Uterine inflammation 97.10 22.50 22 178482 28 90449915
Epistaxis 97.07 22.50 24 178480 85101 90364842
Gonorrhoea 96.11 22.50 27 178477 118 90449825
Metabolic acidosis 95.90 22.50 3 178501 55673 90394270
Drug ineffective 95.79 22.50 3474 175030 1380824 89069119
Exposure during pregnancy 95.70 22.50 204 178300 238206 90211737
Infection 95.53 22.50 378 178126 361716 90088227
Rectal haemorrhage 94.99 22.50 23 178481 82721 90367222
Uterine cervical laceration 94.98 22.50 19 178485 5 90449938
Alanine aminotransferase increased 94.49 22.50 58 178446 118280 90331663
Hypoglycaemia 93.95 22.50 13 178491 69835 90380108
Salpingo-oophoritis 93.82 22.50 27 178477 131 90449812
Hepatitis 93.20 22.50 14 178490 70725 90379218
Aspartate aminotransferase increased 93.14 22.50 43 178461 102894 90347049
Bradycardia 93.00 22.50 25 178479 83822 90366121
Chlamydia test positive 92.37 22.50 20 178484 17 90449926
Actinomycosis 92.30 22.50 45 178459 1091 90448852
Blepharospasm 92.01 22.50 4 178500 55441 90394502
Frequent bowel movements 91.62 22.50 5 178499 56930 90393013
Ear infection 91.50 22.50 14 178490 69761 90380182
Exostosis 91.03 22.50 3 178501 53131 90396812
Genital discharge 89.86 22.50 23 178481 64 90449879
Respiratory disorder 89.74 22.50 11 178493 64805 90385138
Adenomyosis 88.65 22.50 36 178468 556 90449387
Uterine tenderness 88.38 22.50 19 178485 15 90449928
Heart rate increased 87.86 22.50 57 178447 112845 90337098
Colitis 87.35 22.50 16 178488 69926 90380017
Adverse drug reaction 86.70 22.50 62 178442 116639 90333304
Underdose 86.13 22.50 5 178499 54012 90395931
Product contamination 84.66 22.50 43 178461 1141 90448802
Respiratory tract infection 84.36 22.50 9 178495 59069 90390874
Cervical conisation 83.82 22.50 17 178487 6 90449937
Gastrointestinal injury 83.45 22.50 38 178466 786 90449157
Colposcopy 83.29 22.50 18 178486 15 90449928
Dyspnoea exertional 83.17 22.50 20 178484 72268 90377675
Laryngitis 83.12 22.50 4 178500 50749 90399194
Incorrect route of product administration 82.88 22.50 4 178500 50622 90399321
Vulvovaginal pruritus 82.27 22.50 66 178438 3927 90446016
Chest discomfort 81.80 22.50 91 178413 138274 90311669
Nasal congestion 81.65 22.50 31 178473 83383 90366560
Headache 81.48 22.50 1203 177301 861543 89588400
Uterine dilation and curettage 81.18 22.50 40 178464 993 90448950
Diabetes mellitus 80.68 22.50 15 178489 64860 90385083
Myocardial infarction 80.44 22.50 55 178449 105917 90344026
Post abortion haemorrhage 79.45 22.50 21 178483 69 90449874
Anembryonic gestation 78.49 22.50 33 178471 559 90449384
Hallucination 78.38 22.50 17 178487 65942 90384001
Blood pressure systolic increased 78.14 22.50 11 178493 58334 90391609
Intentional device use issue 78.07 22.50 23 178481 123 90449820
Pregnancy test positive 78.05 22.50 24 178480 152 90449791
Rhabdomyolysis 78.04 22.50 6 178498 51250 90398693
Genital pain 76.91 22.50 35 178469 723 90449220
Chemical poisoning 76.13 22.50 19 178485 46 90449897
Therapy interrupted 75.92 22.50 6 178498 50102 90399841
Chloasma 75.71 22.50 23 178481 139 90449804
Tremor 74.92 22.50 116 178388 153057 90296886
Hyperglycaemia 74.77 22.50 7 178497 50963 90398980
Neoplasm progression 74.52 22.50 3 178501 44483 90405460
Alopecia 74.25 22.50 621 177883 494450 89955493
Pulmonary oedema 73.77 22.50 16 178488 62064 90387879
Pregnancy after post coital contraception 73.72 22.50 30 178474 466 90449477
Dysphonia 73.47 22.50 17 178487 63067 90386876
Septic shock 73.32 22.50 37 178467 84123 90365820
Penile pain 73.25 22.50 14 178490 0 90449943
Skin ulcer 73.13 22.50 7 178497 50068 90399875
Uterine contractions abnormal 73.10 22.50 25 178479 231 90449712
Cervix haemorrhage uterine 72.45 22.50 17 178487 28 90449915
Back injury 72.30 22.50 5 178499 46617 90403326
Benign hydatidiform mole 71.98 22.50 23 178481 168 90449775
Acute respiratory failure 71.54 22.50 3 178501 42915 90407028
Joint dislocation 71.47 22.50 4 178500 44578 90405365
Abdominal distension 71.26 22.50 471 178033 130130 90319813
Chronic kidney disease 70.77 22.50 8 178496 50183 90399760
Patient dissatisfaction with device 70.00 22.50 19 178485 71 90449872
Pregnancy on contraceptive 69.92 22.50 39 178465 1256 90448687
Sedation 69.65 22.50 7 178497 48164 90401779
Encephalopathy 69.15 22.50 6 178498 46438 90403505
Lactic acidosis 68.80 22.50 9 178495 50454 90399489
Vulvovaginal mycotic infection 68.65 22.50 73 178431 6241 90443702
Breast swelling 68.64 22.50 42 178462 1612 90448331
Lupus-like syndrome 68.33 22.50 8 178496 48838 90401105
Hepatotoxicity 68.04 22.50 6 178498 45836 90404107
Pneumonia aspiration 67.78 22.50 3 178501 40937 90409006
Migraine with aura 67.77 22.50 54 178450 3182 90446761
Pneumonitis 67.74 22.50 5 178499 44165 90405778
Rash pruritic 67.45 22.50 39 178465 82175 90367768
Abdominal adhesions 67.44 22.50 56 178448 3499 90446444
Hypocalcaemia 67.32 22.50 4 178500 42364 90407579
Incorrect dose administered 66.84 22.50 36 178468 78894 90371049
Pancreatitis 66.61 22.50 27 178477 69799 90380144
Chills 66.42 22.50 98 178406 131883 90318060
Ear pain 66.31 22.50 16 178488 57686 90392257
Coeliac disease 65.78 22.50 6 178498 44604 90405339
Illness 65.68 22.50 40 178464 81929 90368014
Oligomenorrhoea 65.30 22.50 35 178469 1040 90448903
Progesterone decreased 64.86 22.50 20 178484 128 90449815
Uterine stenosis 64.54 22.50 13 178491 4 90449939
Cognitive disorder 64.34 22.50 28 178476 69379 90380564
Endometrial atrophy 64.05 22.50 17 178487 57 90449886
Red blood cell count decreased 63.84 22.50 8 178496 46343 90403600
Hepatic function abnormal 63.72 22.50 8 178496 46280 90403663
Paraesthesia 63.66 22.50 265 178239 250061 90199882
Seborrhoea 63.33 22.50 28 178476 539 90449404
Immunodeficiency 63.26 22.50 6 178498 43228 90406715
Acne cystic 63.12 22.50 31 178473 764 90449179
Cardiac disorder 62.99 22.50 17 178487 56855 90393088
Hepatic failure 62.37 22.50 4 178500 39724 90410219
Serotonin syndrome 62.00 22.50 3 178501 37884 90412059
Human chorionic gonadotropin decreased 61.94 22.50 18 178486 91 90449852
Diverticulitis 61.75 22.50 8 178496 45179 90404764
Expired product administered 61.46 22.50 72 178432 6850 90443093
Blood pressure fluctuation 61.29 22.50 14 178490 52399 90397544
Injection site bruising 61.11 22.50 14 178490 52293 90397650
Agitation 60.74 22.50 28 178476 67070 90382873
Orthostatic hypotension 60.68 22.50 6 178498 41821 90408122
Balance disorder 60.57 22.50 61 178443 97019 90352924
Haematochezia 60.55 22.50 32 178472 70881 90379062
Cyst 60.04 22.50 113 178391 16448 90433495
Mouth ulceration 59.97 22.50 5 178499 39969 90409974
Injection site pruritus 59.80 22.50 16 178488 53818 90396125
Medical device site pain 59.58 22.50 21 178483 214 90449729
Retained placenta or membranes 59.27 22.50 23 178481 313 90449630
Intracranial pressure increased 59.07 22.50 70 178434 6741 90443202
Bone pain 59.07 22.50 24 178480 61959 90387984
Wrong technique in product usage process 58.65 22.50 34 178470 71537 90378406
Treatment noncompliance 58.17 22.50 15 178489 51712 90398231
Respiratory distress 58.07 22.50 5 178499 38941 90411002
Cervical discharge 57.55 22.50 11 178493 0 90449943
Biopsy endometrium 57.55 22.50 11 178493 0 90449943
Ectopic pregnancy under hormonal contraception 57.55 22.50 11 178493 0 90449943
Fallopian tube perforation 57.55 22.50 11 178493 0 90449943
Breast discharge 57.50 22.50 34 178470 1225 90448718
Heart rate decreased 57.39 22.50 17 178487 53488 90396455
Endometrial hypertrophy 57.19 22.50 22 178482 292 90449651
Influenza like illness 57.07 22.50 45 178459 80566 90369377
Vulvovaginal dryness 56.83 22.50 50 178454 3381 90446562
Accidental exposure to product 56.70 22.50 8 178496 42358 90407585
Full blood count abnormal 56.53 22.50 4 178500 36593 90413350
White blood cell count increased 56.45 22.50 31 178473 67210 90382733
Sleep disorder due to a general medical condition 56.37 22.50 10 178494 44728 90405215
Colitis ulcerative 56.36 22.50 24 178480 60242 90389701
Mental status changes 56.27 22.50 10 178494 44669 90405274
Melaena 56.16 22.50 3 178501 34794 90415149
Genito-pelvic pain/penetration disorder 56.09 22.50 12 178492 9 90449934
Pregnancy on oral contraceptive 55.93 22.50 32 178472 1083 90448860
Cervical cyst 55.69 22.50 18 178486 137 90449806
Habitual abortion 55.00 22.50 12 178492 11 90449932
Adnexa uteri cyst 54.48 22.50 18 178486 148 90449795
Oral candidiasis 54.41 22.50 4 178500 35451 90414492
Fluid retention 54.22 22.50 56 178448 88035 90361908
Pericardial effusion 54.19 22.50 5 178499 36828 90413115
Injection site swelling 54.12 22.50 25 178479 59814 90390129
Night sweats 53.48 22.50 108 178396 128658 90321285
Anaphylactic reaction 53.46 22.50 56 178448 87468 90362475
Renal disorder 53.46 22.50 6 178498 37853 90412090
Pulmonary hypertension 52.52 22.50 10 178494 42513 90407430
Flushing 52.52 22.50 58 178446 88433 90361510
Biopsy cervix 52.32 22.50 10 178494 0 90449943
Pelvic haemorrhage 52.19 22.50 17 178487 133 90449810
Hypercalcaemia 52.15 22.50 4 178500 34236 90415707
Myalgia 51.95 22.50 174 178330 174951 90274992
Uterine haematoma 51.65 22.50 13 178491 33 90449910
Blood potassium decreased 51.49 22.50 15 178489 47712 90402231
Unresponsive to stimuli 51.49 22.50 7 178497 38114 90411829
Acute abdomen 51.19 22.50 35 178469 1628 90448315
Pelvic organ injury 50.99 22.50 11 178493 9 90449934
Localised infection 50.90 22.50 4 178500 33558 90416385
Agranulocytosis 50.83 22.50 5 178499 34997 90414946
Therapy cessation 50.75 22.50 6 178498 36355 90413588
Tachycardia 50.74 22.50 151 178353 157522 90292421
Clostridium difficile infection 50.54 22.50 6 178498 36239 90413704
Skin exfoliation 50.54 22.50 36 178468 67877 90382066
Pain in jaw 50.11 22.50 16 178488 47969 90401974
Fear of disease 50.08 22.50 33 178471 1443 90448500
Altered state of consciousness 50.03 22.50 3 178501 31529 90418414
Hypophagia 49.99 22.50 6 178498 35931 90414012
Abortion induced 49.31 22.50 86 178418 11802 90438141
Gastritis 49.12 22.50 11 178493 41742 90408201
Drug eruption 49.03 22.50 6 178498 35401 90414542
Fallopian tube disorder 49.01 22.50 23 178481 511 90449432
Papilloma viral infection 49.01 22.50 35 178469 1747 90448196
Cervix inflammation 49.00 22.50 11 178493 13 90449930
Complication of pregnancy 48.66 22.50 25 178479 680 90449263
Negative thoughts 48.47 22.50 29 178475 1068 90448875
Device allergy 48.44 22.50 13 178491 46 90449897
Abortion spontaneous incomplete 48.10 22.50 12 178492 29 90449914
Breast discomfort 47.56 22.50 24 178480 628 90449315
Uterine cyst 47.28 22.50 22 178482 479 90449464
Chlamydial pelvic inflammatory disease 47.09 22.50 9 178495 0 90449943
Neck pain 46.97 22.50 96 178408 113867 90336076
Ulcer 46.97 22.50 5 178499 32877 90417066
Hypervolaemia 46.74 22.50 5 178499 32752 90417191
Infertility 46.51 22.50 26 178478 841 90449102
Ovarian germ cell teratoma benign 46.48 22.50 16 178488 151 90449792
Vertigo 46.41 22.50 265 178239 69546 90380397
Toxic epidermal necrolysis 46.33 22.50 5 178499 32523 90417420
Throat irritation 46.17 22.50 19 178485 48676 90401267
Adnexal torsion 45.95 22.50 22 178482 512 90449431
Multiple sclerosis relapse 45.55 22.50 23 178481 52282 90397661
Migraine 45.47 22.50 574 177930 189818 90260125
Disability 45.46 22.50 12 178492 40733 90409210
Lethargy 45.01 22.50 35 178469 63104 90386839
Haemangioma of liver 44.96 22.50 30 178474 1340 90448603
Sexually transmitted disease 44.79 22.50 17 178487 217 90449726
Blood pressure decreased 44.54 22.50 49 178455 74846 90375097
Adrenal insufficiency 44.18 22.50 4 178500 29917 90420026
Ovarian rupture 44.17 22.50 12 178492 45 90449898
Affective disorder 44.17 22.50 65 178439 7728 90442215
Perineal pain 44.11 22.50 22 178482 561 90449382
Accidental overdose 43.93 22.50 3 178501 28270 90421673
Coronary artery disease 43.51 22.50 7 178497 33616 90416327
Menopausal symptoms 43.44 22.50 41 178463 3037 90446906
Cerebrovascular accident 42.93 22.50 114 178390 123419 90326524
Uterine malposition 42.73 22.50 13 178491 79 90449864
Swelling face 42.32 22.50 59 178445 81293 90368650
Fallopian tube cyst 41.96 22.50 14 178490 119 90449824
Abnormal withdrawal bleeding 41.91 22.50 12 178492 57 90449886
Chlamydial cervicitis 41.86 22.50 8 178496 0 90449943
Medical device repositioning 41.86 22.50 8 178496 0 90449943
Device deposit issue 41.71 22.50 10 178494 19 90449924
Rash erythematous 41.65 22.50 40 178464 65064 90384879
Bladder perforation 41.61 22.50 15 178489 164 90449779
Tooth disorder 41.31 22.50 6 178498 31084 90418859
Feeling hot 41.15 22.50 56 178448 77952 90371991
Staphylococcal infection 41.15 22.50 22 178482 48417 90401526
Uterine disorder 41.01 22.50 41 178463 3260 90446683
Cytomegalovirus infection 40.82 22.50 3 178501 26599 90423344
Depression suicidal 40.38 22.50 33 178471 2016 90447927
Toxic shock syndrome streptococcal 40.38 22.50 17 178487 289 90449654
Emotional disorder 39.82 22.50 90 178414 14907 90435036
Oral pain 39.70 22.50 8 178496 32675 90417268
Respiratory tract congestion 39.59 22.50 4 178500 27406 90422537
Epilepsy 39.47 22.50 63 178441 82143 90367800
Acute respiratory distress syndrome 39.38 22.50 5 178499 28681 90421262
Genital infection bacterial 39.31 22.50 8 178496 3 90449940
Subchorionic haemorrhage 39.21 22.50 15 178489 196 90449747
Blood alkaline phosphatase increased 39.16 22.50 23 178481 48056 90401887
Oral herpes 39.10 22.50 9 178495 33515 90416428
Dry skin 39.07 22.50 71 178433 88002 90361941
Blood loss anaemia 39.03 22.50 71 178433 10069 90439874
Disorientation 39.02 22.50 19 178485 44095 90405848
Cerebral haemorrhage 38.84 22.50 10 178494 34512 90415431
Rash maculo-papular 38.76 22.50 16 178488 40917 90409026
Laboratory test abnormal 38.61 22.50 17 178487 41837 90408106
Breast cancer in situ 38.51 22.50 30 178474 1710 90448233
Uterine mass 38.47 22.50 18 178486 397 90449546
Cervix carcinoma stage 0 38.43 22.50 20 178484 559 90449384
Pelvic abscess 38.17 22.50 32 178472 2026 90447917
Breast cyst 38.05 22.50 32 178472 2035 90447908
Blood creatine phosphokinase increased 38.00 22.50 10 178494 34013 90415930
Viral infection 37.92 22.50 17 178487 41397 90408546
Dysarthria 37.83 22.50 31 178473 54451 90395492
Haematemesis 37.50 22.50 10 178494 33716 90416227
Pulmonary mass 37.20 22.50 6 178498 28766 90421177
Skin laceration 37.08 22.50 4 178500 26031 90423912
No adverse event 36.96 22.50 245 178259 67737 90382206
Basal cell carcinoma 36.94 22.50 10 178494 33379 90416564
Myomectomy 36.91 22.50 9 178495 19 90449924
Leukocytosis 36.79 22.50 8 178496 30982 90418961
Persistent urogenital sinus 36.62 22.50 7 178497 0 90449943
Liver function test abnormal 36.48 22.50 28 178476 50817 90399126
Skin lesion 36.37 22.50 14 178490 37351 90412592
Myositis 36.24 22.50 3 178501 24125 90425818
Cystitis 36.11 22.50 47 178457 66671 90383272
Transaminases increased 36.10 22.50 14 178490 37178 90412765
Uterine fibrosis 35.92 22.50 10 178494 42 90449901
Conjunctivitis 35.84 22.50 5 178499 26701 90423242
Nodule 35.81 22.50 5 178499 26681 90423262
Joint injury 35.73 22.50 10 178494 32654 90417289
Female genital operation 35.72 22.50 9 178495 23 90449920
Limb injury 35.69 22.50 9 178495 31499 90418444
Invasive ductal breast carcinoma 35.66 22.50 59 178445 7759 90442184
Chronic sinusitis 35.64 22.50 3 178501 23799 90426144
Rib fracture 35.36 22.50 5 178499 26430 90423513
Hydrosalpinx 35.17 22.50 9 178495 25 90449918
Blood sodium decreased 35.17 22.50 6 178498 27607 90422336
Osteonecrosis 35.01 22.50 5 178499 26236 90423707
Drug withdrawal syndrome 34.95 22.50 7 178497 28716 90421227
Gastric ulcer 34.88 22.50 6 178498 27442 90422501
Polycystic ovaries 34.74 22.50 49 178455 5605 90444338
Proteinuria 34.70 22.50 3 178501 23288 90426655
Blood lactate dehydrogenase increased 34.46 22.50 5 178499 25927 90424016
Bone disorder 34.38 22.50 3 178501 23117 90426826
Haematoma 34.26 22.50 17 178487 39031 90410912
Post abortion complication 34.16 22.50 8 178496 13 90449930
Suicide attempt 34.15 22.50 60 178444 75339 90374604
Hepatic steatosis 34.09 22.50 15 178489 36930 90413013
Premature menopause 34.03 22.50 25 178479 1304 90448639
Ovarian vein thrombosis 34.00 22.50 11 178493 84 90449859
Dysgeusia 33.97 22.50 32 178472 52528 90397415
Placenta accreta 33.85 22.50 14 178490 227 90449716
Blood bilirubin increased 33.74 22.50 22 178482 43448 90406495
Hepatocellular injury 33.33 22.50 8 178496 28950 90420993
Dry eye 33.25 22.50 39 178465 57892 90392051
Breast cancer stage II 33.15 22.50 14 178490 35320 90414623
Cholestasis 33.08 22.50 15 178489 36284 90413659
Hormone receptor positive breast cancer 32.84 22.50 20 178484 761 90449182
Galactorrhoea 32.50 22.50 43 178461 4629 90445314
Spinal fracture 32.36 22.50 3 178501 22013 90427930
Ventricular tachycardia 32.29 22.50 5 178499 24703 90425240
Ovarian enlargement 32.20 22.50 18 178486 582 90449361
Disease recurrence 32.13 22.50 17 178487 37636 90412307
Stevens-Johnson syndrome 32.12 22.50 9 178495 29367 90420576
Endometrial adenocarcinoma 32.09 22.50 25 178479 1425 90448518
Haemorrhagic cyst 31.93 22.50 14 178490 264 90449679
Endometrial disorder 31.92 22.50 20 178484 801 90449142
Atelectasis 31.77 22.50 5 178499 24404 90425539
Sinus disorder 31.76 22.50 14 178490 34433 90415510
Genital infection female 31.75 22.50 11 178493 106 90449837
Back disorder 31.71 22.50 6 178498 25625 90424318
Seasonal allergy 31.57 22.50 4 178500 22979 90426964
Ectropion of cervix 31.54 22.50 10 178494 71 90449872
Clostridium difficile colitis 31.49 22.50 7 178497 26699 90423244
Hyperlipidaemia 31.45 22.50 4 178500 22912 90427031
Fear of pregnancy 31.39 22.50 6 178498 0 90449943
Cervical friability 31.39 22.50 6 178498 0 90449943
Fallopian tube obstruction 31.39 22.50 6 178498 0 90449943
Inadequate lubrication 31.39 22.50 6 178498 0 90449943
Metastases to liver 31.17 22.50 9 178495 28798 90421145
Drug ineffective for unapproved indication 31.13 22.50 52 178452 66592 90383351
Retinal vein thrombosis 31.09 22.50 17 178487 526 90449417
Electrolyte imbalance 30.60 22.50 5 178499 23740 90426203
Hemianaesthesia 30.57 22.50 15 178489 369 90449574
Blood test abnormal 30.41 22.50 3 178501 20949 90428994
Ovarian abscess 30.40 22.50 13 178491 230 90449713
Gastroenteritis viral 30.17 22.50 11 178493 30344 90419599
Angina pectoris 30.14 22.50 20 178484 39140 90410803
Gastroenteritis 30.07 22.50 10 178494 29219 90420724
Haematocrit decreased 30.06 22.50 23 178481 41809 90408134
Blood potassium increased 30.04 22.50 3 178501 20746 90429197
Weight loss poor 30.02 22.50 24 178480 1421 90448522
Vulvovaginal swelling 29.97 22.50 19 178485 777 90449166
Bronchospasm 29.96 22.50 3 178501 20706 90429237
Blood pressure diastolic decreased 29.74 22.50 8 178496 26818 90423125
Movement disorder 29.73 22.50 10 178494 29009 90420934
Eye irritation 29.50 22.50 15 178489 33963 90415980
Metastases to bone 29.45 22.50 7 178497 25498 90424445
Abnormal weight gain 29.31 22.50 31 178473 2634 90447309
Lymphopenia 29.08 22.50 5 178499 22876 90427067
Dyskinesia 29.02 22.50 18 178486 36516 90413427
Gilbert's syndrome 28.97 22.50 6 178498 3 90449940
Otosclerosis 28.97 22.50 6 178498 3 90449940
Eosinophilia 28.94 22.50 10 178494 28523 90421420
Breast mass 28.86 22.50 60 178444 9387 90440556
Labelled drug-disease interaction medication error 28.77 22.50 12 178492 199 90449744
Pulmonary arterial hypertension 28.68 22.50 8 178496 26179 90423764
Intentional self-injury 28.54 22.50 11 178493 29323 90420620
Drug dependence 28.53 22.50 11 178493 29316 90420627
Acute hepatic failure 28.52 22.50 5 178499 22556 90427387
Crying 28.51 22.50 113 178391 25532 90424411
Blood pressure diastolic abnormal 28.46 22.50 3 178501 19878 90430065
Adnexa uteri mass 28.34 22.50 17 178487 629 90449314
Procedural headache 28.34 22.50 12 178492 207 90449736
Eating disorder 28.20 22.50 10 178494 28063 90421880
Amnesia 28.10 22.50 114 178390 108391 90341552
Urinary retention 28.09 22.50 20 178484 37724 90412219
Bacteraemia 28.06 22.50 5 178499 22295 90427648
Acute myocardial infarction 27.98 22.50 17 178487 34873 90415070
Neoplasm malignant 27.89 22.50 16 178488 33864 90416079
Pulmonary congestion 27.64 22.50 3 178501 19430 90430513
Polyneuropathy 27.47 22.50 3 178501 19338 90430605
Hysteroscopy 27.44 22.50 8 178496 41 90449902
Angioedema 27.28 22.50 54 178450 64822 90385121
Induced abortion haemorrhage 27.24 22.50 6 178498 6 90449937
Sinus tachycardia 27.23 22.50 11 178493 28502 90421441
Hypothyroidism 27.16 22.50 39 178465 53088 90396855
Retroplacental haematoma 27.08 22.50 11 178493 170 90449773
Lymphocyte count decreased 26.85 22.50 18 178486 35032 90414911
Female sexual dysfunction 26.82 22.50 9 178495 78 90449865
Human papilloma virus test positive 26.82 22.50 17 178487 695 90449248
Ovarian cystectomy 26.79 22.50 11 178493 175 90449768
Intervertebral disc protrusion 26.79 22.50 10 178494 27186 90422757
Cervix carcinoma 26.60 22.50 33 178471 3333 90446610
Lacrimation increased 26.57 22.50 10 178494 27052 90422891
Skin haemorrhage 26.46 22.50 5 178499 21375 90428568
Polymenorrhagia 26.38 22.50 8 178496 48 90449895
Ovulation pain 26.34 22.50 11 178493 183 90449760
Swollen tongue 26.31 22.50 31 178473 45925 90404018
Product quality issue 26.22 22.50 75 178429 79250 90370693
Sneezing 26.21 22.50 13 178491 29856 90420087
Genital injury 26.16 22.50 5 178499 0 90449943
Medical device site calcification 26.16 22.50 5 178499 0 90449943
Pregnancy of unknown location 26.16 22.50 5 178499 0 90449943
Vaginitis chlamydial 26.16 22.50 5 178499 0 90449943
Cervix erythema 26.16 22.50 5 178499 0 90449943
Myometritis 26.16 22.50 5 178499 0 90449943
Sleep apnoea syndrome 26.12 22.50 15 178489 31732 90418211
Genital discomfort 26.05 22.50 9 178495 86 90449857
High risk pregnancy 25.98 22.50 10 178494 133 90449810
Blood glucose decreased 25.95 22.50 7 178497 23422 90426521
Lipoedema 25.91 22.50 13 178491 336 90449607
Toothache 25.86 22.50 6 178498 22224 90427719
Caesarean section 25.82 22.50 88 178416 18489 90431454
Infusion site pain 25.78 22.50 4 178500 19734 90430209
Foetal exposure during pregnancy 25.68 22.50 28 178476 42947 90406996
Laparoscopic surgery 25.61 22.50 7 178497 27 90449916
Syncope 25.56 22.50 385 178119 132278 90317665
Hallucination, visual 25.39 22.50 7 178497 23085 90426858
Glaucoma 25.38 22.50 5 178499 20750 90429193
Libido disorder 25.33 22.50 8 178496 56 90449887
Head injury 25.29 22.50 15 178489 31173 90418770
Cyanosis 25.28 22.50 4 178500 19451 90430492
Osteopenia 25.24 22.50 7 178497 22995 90426948
Back pain 25.20 22.50 810 177694 316365 90133578
Neutrophil count increased 25.17 22.50 4 178500 19386 90430557
Eye pain 25.06 22.50 30 178474 44138 90405805
Drug tolerance 24.90 22.50 3 178501 17913 90432030
Ectopic pregnancy termination 24.82 22.50 6 178498 12 90449931
Skin infection 24.80 22.50 3 178501 17861 90432082
Abortion infected 24.49 22.50 7 178497 33 90449910
Amniotic cavity infection 24.45 22.50 21 178483 1375 90448568
Mitral valve incompetence 24.44 22.50 7 178497 22517 90427426
Haemoptysis 24.35 22.50 18 178486 33302 90416641
Small intestinal obstruction 24.18 22.50 6 178498 21228 90428715
Posterior reversible encephalopathy syndrome 24.14 22.50 7 178497 22332 90427611
Bronchiectasis 24.12 22.50 7 178497 22323 90427620
Product administration error 23.95 22.50 11 178493 26412 90423531
Diabetes mellitus inadequate control 23.93 22.50 4 178500 18680 90431263
Perinatal depression 23.92 22.50 17 178487 842 90449101
Nervousness 23.77 22.50 131 178373 33925 90416018
Suicidal ideation 23.69 22.50 236 178268 73619 90376324
Injection site rash 23.62 22.50 9 178495 24164 90425779
Joint effusion 23.58 22.50 5 178499 19705 90430238
Withdrawal bleed 23.58 22.50 8 178496 72 90449871
Hepatic cytolysis 23.51 22.50 16 178488 30900 90419043
Retinal vascular thrombosis 23.13 22.50 10 178494 182 90449761
Rash vesicular 23.07 22.50 4 178500 18193 90431750
Hot flush 23.07 22.50 198 178306 59290 90390653
Cardiac murmur 23.07 22.50 4 178500 18190 90431753
Gout 23.00 22.50 3 178501 16856 90433087
Blood follicle stimulating hormone increased 22.78 22.50 10 178494 189 90449754
Ankle fracture 22.72 22.50 6 178498 20364 90429579
Blood follicle stimulating hormone abnormal 22.70 22.50 5 178499 5 90449938
Lactation disorder 22.69 22.50 13 178491 441 90449502
Imminent abortion 22.63 22.50 6 178498 20 90449923
Spinal osteoarthritis 22.61 22.50 5 178499 19143 90430800
Ocular hyperaemia 22.53 22.50 20 178484 33778 90416165
Coordination abnormal 22.51 22.50 7 178497 21349 90428594

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Penile pain 3287.95 693.96 362 195 1426 42619352

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Device expulsion 114921.41 27.48 21309 117322 9582 110441086
Device dislocation 39584.93 27.48 8899 129732 22805 110427863
Genital haemorrhage 20708.08 27.48 4048 134583 3204 110447464
Uterine perforation 15992.77 27.48 3233 135398 3607 110447061
Complication of device insertion 13091.51 27.48 2865 135766 5973 110444695
Pregnancy with contraceptive device 12467.57 27.48 2396 136235 1511 110449157
Procedural pain 11810.84 27.48 3489 135142 32076 110418592
Abdominal pain lower 9924.96 27.48 3086 135545 34197 110416471
Embedded device 7932.50 27.48 1653 136978 2380 110448288
Pelvic pain 7103.11 27.48 1969 136662 13973 110436695
Vaginal haemorrhage 6168.77 27.48 1956 136675 23118 110427550
Ectopic pregnancy with contraceptive device 5273.17 27.48 969 137662 269 110450399
Device breakage 5106.30 27.48 1474 137157 12295 110438373
Device difficult to use 5020.56 27.48 1562 137069 17243 110433425
Complication of device removal 4871.22 27.48 1136 137495 3484 110447184
Device use issue 4396.84 27.48 1007 137624 2777 110447891
Heavy menstrual bleeding 4299.63 27.48 1343 137288 15022 110435646
Medical device discomfort 4047.47 27.48 838 137793 1138 110449530
Post procedural discomfort 3995.19 27.48 763 137868 434 110450234
Device issue 3737.76 27.48 1463 137168 33072 110417596
Complication associated with device 3386.66 27.48 1179 137452 18894 110431774
Amenorrhoea 2950.24 27.48 881 137750 8350 110442318
Medical device pain 2922.81 27.48 604 138027 806 110449862
Uterine rupture 2588.54 27.48 496 138135 295 110450373
Dyspareunia 2588.22 27.48 594 138037 1655 110449013
Emotional distress 2252.25 27.48 1107 137524 43740 110406928
Injury 2169.37 27.48 1787 136844 175478 110275190
Unintentional medical device removal 1950.45 27.48 637 137994 8286 110442382
Uterine spasm 1738.27 27.48 343 138288 293 110450375
Post procedural haemorrhage 1683.66 27.48 659 137972 14853 110435815
Device deployment issue 1681.72 27.48 479 138152 3774 110446894
Intermenstrual bleeding 1531.60 27.48 499 138132 6435 110444233
Ovarian cyst 1487.90 27.48 585 138046 13345 110437323
Haemorrhage in pregnancy 1465.15 27.48 354 138277 1314 110449354
Expired device used 1437.45 27.48 297 138334 395 110450273
Uterine cervix stenosis 1327.75 27.48 244 138387 67 110450601
Abdominal pain 1289.36 27.48 2304 136327 510685 109939983
Ruptured ectopic pregnancy 1285.76 27.48 255 138376 230 110450438
Loss of libido 1261.87 27.48 358 138273 2775 110447893
Procedural haemorrhage 1216.64 27.48 395 138236 5032 110445636
Dysmenorrhoea 1176.84 27.48 350 138281 3260 110447408
Off label use of device 1164.07 27.48 236 138395 265 110450403
Menstruation irregular 1087.97 27.48 369 138262 5428 110445240
Intentional device misuse 985.01 27.48 227 138404 647 110450021
Uterine haemorrhage 960.05 27.48 297 138334 3197 110447471
Coital bleeding 946.35 27.48 192 138439 217 110450451
Device physical property issue 915.32 27.48 292 138339 3502 110447166
Pneumonia 907.89 27.48 47 138584 876667 109574001
Diarrhoea 904.49 27.48 169 138462 1139336 109311332
Abortion spontaneous 862.99 27.48 537 138094 33745 110416923
Contraindicated device used 829.80 27.48 146 138485 0 110450668
Pelvic inflammatory disease 827.83 27.48 222 138409 1358 110449310
Depression 814.22 27.48 1440 137191 315895 110134773
Uterine leiomyoma 809.84 27.48 321 138310 7479 110443189
Anxiety 808.16 27.48 1505 137126 343573 110107095
Medical device monitoring error 795.69 27.48 140 138491 0 110450668
Internal injury 779.20 27.48 161 138470 214 110450454
Death 768.37 27.48 24 138607 698845 109751823
Device placement issue 756.06 27.48 213 138418 1604 110449064
Vaginal discharge 754.93 27.48 393 138238 17515 110433153
Ectopic pregnancy 736.98 27.48 220 138411 2077 110448591
Acute kidney injury 708.76 27.48 19 138612 635411 109815257
Dyspnoea 690.06 27.48 264 138367 1106608 109344060
Hypomenorrhoea 676.31 27.48 150 138481 337 110450331
Off label use 578.41 27.48 620 138011 1499565 108951103
Toxicity to various agents 552.69 27.48 10 138621 480545 109970123
Acne 548.33 27.48 402 138229 33118 110417550
Fall 541.15 27.48 62 138569 603420 109847248
Infertility female 521.28 27.48 122 138509 380 110450288
Breast cancer female 512.32 27.48 269 138362 12199 110438469
Abnormal uterine bleeding 509.75 27.48 149 138482 1298 110449370
Menstrual disorder 497.04 27.48 197 138434 4587 110446081
Condition aggravated 492.05 27.48 155 138476 734681 109715987
Uterine pain 481.49 27.48 98 138533 114 110450554
Confusional state 438.45 27.48 41 138590 468639 109982029
Breast pain 437.39 27.48 225 138406 9775 110440893
Device use error 436.96 27.48 218 138413 8871 110441797
Intra-uterine contraceptive device removal 436.60 27.48 78 138553 7 110450661
Pain 434.33 27.48 2346 136285 952609 109498059
Menometrorrhagia 431.11 27.48 118 138513 788 110449880
Drug hypersensitivity 429.40 27.48 38 138593 454052 109996616
Breast tenderness 429.29 27.48 151 138480 2489 110448179
Hypotension 428.98 27.48 71 138560 523778 109926890
Libido decreased 423.49 27.48 187 138444 5748 110444920
Cervical dysplasia 412.47 27.48 148 138483 2592 110448076
Infusion related reaction 408.24 27.48 16 138615 381146 110069522
Rash 408.08 27.48 264 138367 820700 109629968
Neutropenia 403.70 27.48 15 138616 374605 110076063
Mood swings 401.41 27.48 286 138345 22526 110428142
Pyrexia 400.76 27.48 324 138307 897941 109552727
Menstruation delayed 399.73 27.48 130 138501 1664 110449004
Haemoperitoneum 398.16 27.48 174 138457 5214 110445454
Joint swelling 395.51 27.48 46 138585 442799 110007869
Drug intolerance 381.67 27.48 35 138596 406477 110044191
Febrile neutropenia 379.99 27.48 3 138628 316764 110133904
Scar 371.47 27.48 243 138388 16638 110434030
Drug interaction 363.35 27.48 90 138541 500093 109950575
Device defective 361.14 27.48 147 138484 3675 110446993
Anaemia 354.32 27.48 122 138509 546964 109903704
Thrombocytopenia 344.30 27.48 24 138607 348861 110101807
Nasopharyngitis 342.24 27.48 45 138586 394316 110056352
Vomiting 335.85 27.48 389 138242 910286 109540382
Device failure 323.43 27.48 165 138466 7042 110443626
Decreased appetite 318.81 27.48 100 138531 475746 109974922
Meningioma 317.78 27.48 151 138480 5514 110445154
Stomatitis 317.42 27.48 4 138627 270238 110180430
Salpingectomy 313.44 27.48 75 138556 264 110450404
Arthropathy 311.49 27.48 11 138620 287511 110163157
Hypertension 311.35 27.48 125 138506 509959 109940709
Cough 311.08 27.48 96 138535 461545 109989123
Vaginal odour 309.09 27.48 79 138552 388 110450280
Fear 306.44 27.48 245 138386 22948 110427720
Peripheral swelling 292.76 27.48 73 138558 403961 110046707
Wheezing 290.45 27.48 6 138625 255224 110195444
Hepatic enzyme increased 284.74 27.48 34 138597 320858 110129810
Depressed mood 280.05 27.48 363 138268 60446 110390222
Intra-abdominal haemorrhage 274.25 27.48 134 138497 5208 110445460
Treatment failure 273.70 27.48 19 138612 277215 110173453
Wound 273.00 27.48 4 138627 234433 110216235
Idiopathic intracranial hypertension 270.67 27.48 121 138510 3831 110446837
Rheumatoid arthritis 270.20 27.48 30 138601 299583 110151085
Pelvic discomfort 269.11 27.48 75 138556 540 110450128
Anhedonia 268.15 27.48 192 138439 15236 110435432
Lower respiratory tract infection 267.95 27.48 8 138623 243098 110207570
Completed suicide 263.48 27.48 9 138622 242372 110208296
Uterine scar 263.26 27.48 50 138581 26 110450642
Glossodynia 261.98 27.48 3 138628 222001 110228667
Asthenia 260.61 27.48 288 138343 688711 109761957
Therapeutic product effect decreased 258.99 27.48 11 138620 244305 110206363
Polymenorrhoea 255.30 27.48 83 138548 1061 110449607
Pemphigus 252.75 27.48 3 138628 214567 110236101
Hypersensitivity 251.39 27.48 96 138535 403902 110046766
Arthralgia 251.23 27.48 368 138263 779264 109671404
Dehydration 249.50 27.48 29 138602 279482 110171186
Systemic lupus erythematosus 249.42 27.48 18 138613 254320 110196348
Disease progression 249.04 27.48 14 138617 244020 110206648
Swelling 247.45 27.48 67 138564 350974 110099694
Adnexa uteri pain 243.44 27.48 63 138568 328 110450340
Product use in unapproved indication 241.45 27.48 130 138501 447247 110003421
Atrial fibrillation 241.24 27.48 11 138620 229631 110221037
Renal failure 240.83 27.48 10 138621 226564 110224104
Pancytopenia 238.20 27.48 5 138626 209608 110241060
Contraindicated product administered 236.63 27.48 20 138611 248247 110202421
Overdose 233.77 27.48 15 138616 233779 110216889
Hyponatraemia 233.39 27.48 9 138622 217644 110233024
Impaired healing 230.59 27.48 3 138628 196714 110253954
Intentional product use issue 228.18 27.48 23 138608 247883 110202785
Therapeutic product effect incomplete 227.88 27.48 13 138618 223792 110226876
Sinusitis 226.02 27.48 48 138583 296640 110154028
Malaise 221.38 27.48 312 138319 671507 109779161
Procedural dizziness 220.58 27.48 46 138585 66 110450602
White blood cell count decreased 219.94 27.48 18 138613 229372 110221296
Platelet count decreased 218.43 27.48 19 138612 230424 110220244
Musculoskeletal stiffness 213.71 27.48 45 138586 279777 110170891
Product dose omission issue 212.94 27.48 69 138562 321713 110128955
Progesterone receptor assay positive 211.94 27.48 51 138580 185 110450483
Salpingitis 209.18 27.48 50 138581 175 110450493
Respiratory failure 208.96 27.48 16 138615 215316 110235352
Sepsis 208.29 27.48 75 138556 327271 110123397
Somnolence 207.30 27.48 58 138573 297391 110153277
Endometritis 206.59 27.48 68 138563 906 110449762
Weight decreased 205.54 27.48 171 138460 467886 109982782
Endometriosis 205.52 27.48 103 138528 4231 110446437
Abortion of ectopic pregnancy 204.87 27.48 39 138592 21 110450647
Cardiac arrest 204.79 27.48 10 138621 196743 110253925
Cardiac failure 203.79 27.48 7 138624 187619 110263049
Mobility decreased 203.71 27.48 28 138603 237394 110213274
Malignant neoplasm progression 203.13 27.48 3 138628 174564 110276104
Premenstrual syndrome 202.93 27.48 60 138571 546 110450122
Breast cancer 202.84 27.48 246 138385 38296 110412372
Drug abuse 202.50 27.48 4 138627 177407 110273261
Fatigue 202.12 27.48 813 137818 1215145 109235523
Pruritus 197.65 27.48 264 138367 581296 109869372
Bacterial vulvovaginitis 197.16 27.48 60 138571 608 110450060
Osteoarthritis 194.27 27.48 8 138623 182615 110268053
Retained products of conception 193.43 27.48 43 138588 98 110450570
Gastrointestinal haemorrhage 191.93 27.48 3 138628 165515 110285153
Hypokalaemia 190.77 27.48 9 138622 182439 110268229
Vulvovaginal pain 190.19 27.48 86 138545 2798 110447870
Renal impairment 188.65 27.48 12 138619 188433 110262235
Dry mouth 188.10 27.48 17 138614 199931 110250737
Blister 187.72 27.48 30 138601 227346 110223322
Bacterial vaginosis 186.02 27.48 69 138562 1333 110449335
Contusion 185.60 27.48 34 138597 233327 110217341
Erythema 185.03 27.48 67 138564 291380 110159288
Lung disorder 184.70 27.48 10 138621 180037 110270631
C-reactive protein increased 183.91 27.48 27 138604 217892 110232776
Neuropathy peripheral 183.78 27.48 10 138621 179267 110271401
Pain in extremity 183.57 27.48 204 138427 486914 109963754
Constipation 182.92 27.48 111 138520 357675 110092993
Vaginal infection 182.40 27.48 111 138520 6693 110443975
Uterine cervical pain 182.23 27.48 34 138597 13 110450655
Presyncope 180.07 27.48 262 138369 48625 110402043
Oedema peripheral 179.46 27.48 94 138537 328566 110122102
Blood cholesterol increased 178.53 27.48 14 138617 184771 110265897
Type 2 diabetes mellitus 178.27 27.48 11 138620 177221 110273447
Asthma 177.79 27.48 47 138584 250244 110200424
Intentional medical device removal by patient 177.58 27.48 52 138579 456 110450212
Oedema 177.24 27.48 26 138605 209950 110240718
Ill-defined disorder 177.18 27.48 4 138627 156849 110293819
Psoriatic arthropathy 176.59 27.48 20 138611 196741 110253927
Haemorrhagic ovarian cyst 176.42 27.48 55 138576 608 110450060
Blood creatinine increased 176.29 27.48 14 138617 182875 110267793
Folliculitis 176.16 27.48 8 138623 167645 110283023
Suppressed lactation 175.30 27.48 47 138584 287 110450381
Tubo-ovarian abscess 174.37 27.48 49 138582 365 110450303
Psychological trauma 174.17 27.48 69 138562 1604 110449064
Pleural effusion 172.99 27.48 13 138618 177696 110272972
Ovarian cyst ruptured 170.76 27.48 63 138568 1198 110449470
Cardiac failure congestive 169.99 27.48 4 138627 150996 110299672
Liver injury 169.26 27.48 4 138627 150409 110300259
Mood altered 169.11 27.48 169 138462 21206 110429462
Hydrometra 168.97 27.48 33 138598 25 110450643
Oestrogen receptor assay positive 168.45 27.48 47 138584 340 110450328
Device malfunction 168.01 27.48 183 138448 25375 110425293
Gait disturbance 166.62 27.48 70 138561 278138 110172530
Oxygen saturation decreased 166.56 27.48 7 138624 156975 110293693
Pelvic adhesions 161.74 27.48 43 138588 253 110450415
Uterine infection 160.93 27.48 46 138585 367 110450301
Chest pain 160.90 27.48 141 138490 376234 110074434
Hypertrichosis 159.86 27.48 66 138565 1712 110448956
Irritable bowel syndrome 157.08 27.48 13 138618 164202 110286466
Multiple organ dysfunction syndrome 156.95 27.48 8 138623 151702 110298966
Device intolerance 156.63 27.48 34 138597 66 110450602
Gastrointestinal disorder 156.34 27.48 54 138577 241898 110208770
Loop electrosurgical excision procedure 156.28 27.48 28 138603 3 110450665
Pelvic fluid collection 156.25 27.48 56 138575 977 110449691
Interstitial lung disease 155.66 27.48 4 138627 139330 110311338
Haemoglobin decreased 154.80 27.48 59 138572 248668 110202000
Muscular weakness 154.54 27.48 59 138572 248409 110202259
Product use issue 153.39 27.48 101 138530 311594 110139074
Irritability 153.03 27.48 240 138391 47569 110403099
Arthritis 153.02 27.48 16 138615 167570 110283098
Diffuse alopecia 152.24 27.48 59 138572 1291 110449377
COVID-19 151.07 27.48 59 138572 245001 110205667
Bursitis 147.97 27.48 3 138628 129915 110320753
Panic attack 147.88 27.48 182 138449 28758 110421910
Uterine polyp 146.39 27.48 64 138567 1919 110448749
Inflammation 145.62 27.48 32 138599 193206 110257462
Vulvovaginal discomfort 145.36 27.48 65 138566 2059 110448609
Hyperkalaemia 144.25 27.48 6 138625 135790 110314878
Procedural anxiety 142.87 27.48 50 138581 811 110449857
Nausea 142.87 27.48 936 137695 1234754 109215914
Patient-device incompatibility 142.44 27.48 37 138594 196 110450472
Procedural nausea 140.91 27.48 54 138577 1145 110449523
Peritoneal adhesions 140.84 27.48 40 138591 311 110450357
Hypoxia 140.04 27.48 5 138626 129510 110321158
Joint range of motion decreased 138.02 27.48 3 138628 121829 110328839
Blood pressure increased 137.94 27.48 76 138555 258297 110192371
Fibromyalgia 137.84 27.48 24 138607 170885 110279783
Hirsutism 137.01 27.48 59 138572 1704 110448964
Therapy non-responder 136.22 27.48 18 138613 157289 110293379
Abortion missed 134.63 27.48 56 138575 1481 110449187
Smear cervix abnormal 133.17 27.48 66 138565 2646 110448022
Rhabdomyolysis 128.97 27.48 5 138626 120396 110330272
Leukopenia 128.90 27.48 17 138614 148774 110301894
Drug ineffective 128.64 27.48 2642 135989 1517898 108932770
Chlamydial infection 128.23 27.48 43 138588 609 110450059
Uterine injury 127.85 27.48 26 138605 30 110450638
Bradycardia 127.27 27.48 21 138610 155496 110295172
Haematosalpinx 127.03 27.48 23 138608 4 110450664
Intentional overdose 125.32 27.48 11 138620 132490 110318178
Neutrophil count decreased 123.16 27.48 7 138624 120934 110329734
Hormone level abnormal 123.07 27.48 60 138571 2320 110448348
Depressed level of consciousness 122.57 27.48 4 138627 112274 110338394
Cervicitis 122.14 27.48 35 138596 282 110450386
Uterine enlargement 121.66 27.48 46 138585 939 110449729
Bronchitis 120.37 27.48 25 138606 157007 110293661
Pregnancy with implant contraceptive 120.27 27.48 59 138572 2313 110448355
Coma 119.48 27.48 7 138624 117862 110332806
Gynaecological chlamydia infection 119.35 27.48 21 138610 0 110450668
Liver disorder 119.13 27.48 18 138613 142225 110308443
Myocardial infarction 118.78 27.48 46 138585 192037 110258631
Product shape issue 118.63 27.48 25 138606 39 110450629
Cardio-respiratory arrest 117.05 27.48 7 138624 115829 110334839
Injection site pain 116.15 27.48 39 138592 177883 110272785
Productive cough 115.22 27.48 7 138624 114298 110336370
Migraine 114.97 27.48 473 138158 171179 110279489
Inappropriate schedule of product administration 114.47 27.48 56 138575 203581 110247087
Hypoglycaemia 114.40 27.48 8 138623 116096 110334572
Gastrooesophageal reflux disease 113.13 27.48 42 138589 179934 110270734
Septic shock 112.94 27.48 29 138602 157499 110293169
Pelvic infection 112.92 27.48 35 138596 379 110450289
Influenza 112.26 27.48 36 138595 169065 110281603
Medical device site discomfort 110.89 27.48 31 138600 226 110450442
Blood glucose increased 110.42 27.48 17 138614 132479 110318189
Cervical polyp 109.84 27.48 31 138600 235 110450433
Uterine adhesions 108.83 27.48 22 138609 24 110450644
Cellulitis 107.73 27.48 15 138616 126001 110324667
Alanine aminotransferase increased 107.20 27.48 48 138583 183725 110266943
Hospitalisation 106.54 27.48 24 138607 142469 110308199
Mucosal inflammation 106.49 27.48 3 138628 96138 110354530
Endometrial cancer 106.22 27.48 55 138576 2421 110448247
Procedural vomiting 105.94 27.48 42 138589 978 110449690
Abdominal discomfort 105.35 27.48 209 138422 393649 110057019
Dyspepsia 105.10 27.48 54 138577 190911 110259757
Dysphagia 105.03 27.48 31 138600 153569 110297099
Cervix disorder 105.00 27.48 32 138599 326 110450342
Aspartate aminotransferase increased 104.50 27.48 35 138596 159901 110290767
Uterine cervical laceration 104.35 27.48 19 138612 4 110450664
Intentional product misuse 104.28 27.48 20 138611 132884 110317784
Adenomyosis 103.62 27.48 32 138599 342 110450326
Musculoskeletal pain 103.37 27.48 50 138581 182973 110267695
Uterine inflammation 102.91 27.48 21 138610 25 110450643
Epistaxis 97.39 27.48 22 138609 130350 110320318
Wound infection 96.95 27.48 6 138625 96459 110354209
Drug-induced liver injury 96.50 27.48 17 138614 120050 110330618
Prescribed overdose 96.03 27.48 3 138628 87578 110363090
Herpes zoster 94.80 27.48 12 138619 108367 110342301
Endometrial hyperplasia 94.80 27.48 35 138596 667 110450001
Diabetes mellitus 94.67 27.48 8 138623 99373 110351295
Hepatic function abnormal 94.65 27.48 4 138627 89291 110361377
Gait inability 94.20 27.48 27 138604 136349 110314319
Uterine dilation and curettage 93.27 27.48 34 138597 624 110450044
Peripheral venous disease 91.81 27.48 3 138628 84114 110366554
Obesity 91.21 27.48 16 138615 113335 110337333
Rectal haemorrhage 89.95 27.48 20 138611 119813 110330855
Device ineffective 88.99 27.48 25 138606 186 110450482
Colposcopy 88.18 27.48 16 138615 3 110450665
Upper respiratory tract infection 87.09 27.48 28 138603 131300 110319368
Lactic acidosis 86.97 27.48 8 138623 92803 110357865
Maternal exposure during pregnancy 86.13 27.48 116 138515 254767 110195901
Oropharyngeal pain 85.97 27.48 31 138600 135245 110315423
Colitis 85.56 27.48 13 138618 102310 110348358
Post abortion haemorrhage 85.52 27.48 20 138611 62 110450606
Road traffic accident 84.60 27.48 16 138615 107382 110343286
Sciatica 83.88 27.48 9 138622 92390 110358278
Osteoporosis 83.05 27.48 7 138624 87145 110363523
Procedural complication 82.75 27.48 75 138556 8330 110442338
Agitation 82.61 27.48 20 138611 113031 110337637
Focal nodular hyperplasia 82.46 27.48 34 138597 879 110449789
Hallucination 82.31 27.48 14 138617 101418 110349250
Uterine tenderness 81.43 27.48 16 138615 13 110450655
Genital discharge 81.27 27.48 17 138614 25 110450643
Hepatitis 81.17 27.48 9 138622 90045 110360623
Acute respiratory failure 81.03 27.48 3 138628 75257 110375411
Hyperglycaemia 80.64 27.48 7 138624 85083 110365585
Medical device entrapment 80.21 27.48 15 138616 6 110450662
Pulmonary oedema 79.28 27.48 15 138616 100644 110350024
Pneumonitis 79.26 27.48 4 138627 76527 110374141
Dyspnoea exertional 78.85 27.48 17 138614 104043 110346625
Encephalopathy 78.67 27.48 6 138625 81049 110369619
Vulvovaginal pruritus 78.32 27.48 50 138581 3281 110447387
Blood pressure systolic increased 78.18 27.48 7 138624 82984 110367684
Memory impairment 77.97 27.48 79 138552 196865 110253803
Abortion induced 77.86 27.48 71 138560 7948 110442720
Breast cancer stage III 76.38 27.48 6 138625 79111 110371557
Salpingo-oophoritis 76.21 27.48 20 138611 111 110450557
Benign hydatidiform mole 75.79 27.48 19 138612 85 110450583
Vulvovaginal mycotic infection 75.75 27.48 59 138572 5318 110445350
Red blood cell sedimentation rate increased 75.42 27.48 6 138625 78296 110372372
Chlamydia test positive 75.15 27.48 16 138615 27 110450641
Papilloedema 74.69 27.48 67 138564 7342 110443326
Insomnia 74.52 27.48 219 138412 360371 110090297
Cataract 74.08 27.48 7 138624 79478 110371190
Cervix injury 73.88 27.48 13 138618 0 110450668
Hepatic adenoma 73.22 27.48 26 138605 441 110450227
Melaena 73.14 27.48 3 138628 68754 110381914
Frequent bowel movements 73.09 27.48 4 138627 71386 110379282
Therapeutic response decreased 72.64 27.48 16 138615 96483 110354185
Abdominal adhesions 72.47 27.48 52 138579 4138 110446530
Pregnancy test positive 72.47 27.48 19 138612 105 110450563
Endometrial thickening 71.44 27.48 26 138605 475 110450193
Patient dissatisfaction with device 71.18 27.48 13 138618 3 110450665
Cervix haemorrhage uterine 70.91 27.48 14 138617 12 110450656
Haematochezia 70.86 27.48 28 138603 115496 110335172
Live birth 70.81 27.48 4 138627 69480 110381188
Chronic kidney disease 70.36 27.48 7 138624 76284 110374384
Liver function test increased 70.16 27.48 13 138618 88535 110362133
Respiratory distress 70.08 27.48 4 138627 68870 110381798
Hepatic failure 69.91 27.48 4 138627 68735 110381933
Cervical conisation 68.95 27.48 13 138618 6 110450662
Cervical cyst 68.94 27.48 17 138614 70 110450598
Heart rate increased 68.84 27.48 48 138583 143786 110306882
Uterine contractions abnormal 68.64 27.48 19 138612 133 110450535
Hepatic cirrhosis 68.58 27.48 4 138627 67622 110383046
Neoplasm progression 68.11 27.48 3 138628 64592 110386076
Rhinorrhoea 67.88 27.48 22 138609 102644 110348024
Mental status changes 67.62 27.48 8 138623 76114 110374554
Respiratory tract infection 67.57 27.48 6 138625 71611 110379057
Actinomyces test positive 66.76 27.48 14 138617 21 110450647
Adnexa uteri cyst 66.50 27.48 16 138615 58 110450610
Retained placenta or membranes 66.49 27.48 21 138610 243 110450425
Tremor 66.34 27.48 94 138537 202138 110248530
Chills 66.15 27.48 85 138546 190495 110260173
Blood pressure fluctuation 66.13 27.48 8 138623 74816 110375852
Hypocalcaemia 65.88 27.48 4 138627 65362 110385306
Pregnancy on oral contraceptive 65.43 27.48 29 138602 899 110449769
Sedation 65.31 27.48 6 138625 69677 110380991
Coronary artery disease 65.03 27.48 7 138624 71683 110378985
Agranulocytosis 64.69 27.48 3 138628 61757 110388911
Skin ulcer 63.83 27.48 4 138627 63641 110387027
Incorrect dose administered 63.76 27.48 25 138606 103616 110347052
Complication of pregnancy 63.61 27.48 23 138608 412 110450256
Nasal congestion 63.34 27.48 22 138609 98260 110352408
Fallopian tube disorder 63.15 27.48 23 138608 421 110450247
Oligomenorrhoea 62.85 27.48 28 138603 879 110449789
Loss of personal independence in daily activities 61.90 27.48 58 138573 149962 110300706
Seborrhoea 61.80 27.48 24 138607 528 110450140
Blood creatine phosphokinase increased 61.75 27.48 9 138622 73068 110377600
Psoriasis 61.52 27.48 51 138580 139942 110310726
Gastrointestinal injury 61.40 27.48 35 138596 1868 110448800
Orthostatic hypotension 61.30 27.48 6 138625 66243 110384425
Underdose 60.85 27.48 5 138626 63549 110387119
Injection site erythema 60.83 27.48 21 138610 94155 110356513
Anembryonic gestation 59.94 27.48 22 138609 412 110450256
Fear of disease 59.88 27.48 31 138600 1364 110449304
Respiratory disorder 59.83 27.48 9 138622 71373 110379295
General physical health deterioration 59.69 27.48 302 138329 424993 110025675
Abdominal distension 59.66 27.48 400 138231 174703 110275965
Acute myocardial infarction 58.94 27.48 16 138615 83761 110366907
Toxic epidermal necrolysis 58.63 27.48 3 138628 56724 110393944
Breast swelling 58.57 27.48 32 138599 1572 110449096
White blood cell count increased 58.53 27.48 24 138607 96818 110353850
Breast discharge 58.46 27.48 27 138604 923 110449745
Red blood cell count decreased 58.38 27.48 7 138624 65916 110384752
Hepatotoxicity 57.99 27.48 6 138625 63394 110387274
Full blood count abnormal 57.82 27.48 3 138628 56049 110394619
Pelvic organ injury 57.73 27.48 11 138620 6 110450662
Habitual abortion 57.73 27.48 11 138620 6 110450662
Prescribed underdose 57.52 27.48 7 138624 65167 110385501
Joint stiffness 57.48 27.48 8 138623 67235 110383433
Injection site reaction 57.29 27.48 20 138611 89050 110361618
Cerebral haemorrhage 57.28 27.48 7 138624 64961 110385707
Genital pain 56.92 27.48 30 138601 1370 110449298
Pancreatitis 56.82 27.48 23 138608 93510 110357158
Weight increased 56.73 27.48 788 137843 418856 110031812
Cervix carcinoma stage 0 56.73 27.48 19 138612 268 110450400
Pericardial effusion 56.20 27.48 4 138627 57213 110393455
Heart rate decreased 56.02 27.48 17 138614 82739 110367929
Cytomegalovirus infection 55.89 27.48 3 138628 54441 110396227
Product contamination 55.64 27.48 33 138598 1898 110448770
Autoimmune disorder 55.48 27.48 8 138623 65475 110385193
Uterine malposition 55.38 27.48 12 138619 23 110450645
Urticaria 55.32 27.48 209 138422 318648 110132020
Invasive ductal breast carcinoma 55.26 27.48 54 138577 6592 110444076
Human chorionic gonadotropin decreased 55.24 27.48 14 138617 66 110450602
Urinary tract infection 55.24 27.48 216 138415 326066 110124602
Pregnancy after post coital contraception 55.17 27.48 19 138612 293 110450375
Treatment noncompliance 55.14 27.48 12 138619 72978 110377690
Migraine with aura 55.10 27.48 41 138590 3451 110447217
Chest discomfort 54.87 27.48 83 138548 173765 110276903
Abdominal pain upper 54.81 27.48 238 138393 348873 110101795
Acute respiratory distress syndrome 54.40 27.48 3 138628 53195 110397473
Uterine haematoma 54.40 27.48 12 138619 26 110450642
Cholestasis 54.39 27.48 8 138623 64510 110386158
Dysphonia 54.37 27.48 14 138617 75915 110374753
Vulvovaginal dryness 54.30 27.48 37 138594 2710 110447958
Fallopian tube cyst 54.27 27.48 13 138618 46 110450622
Ovarian germ cell teratoma benign 54.06 27.48 13 138618 47 110450621
Vertigo 53.94 27.48 234 138397 86636 110364032
Wrong technique in product usage process 53.85 27.48 21 138610 87327 110363341
Progesterone decreased 53.63 27.48 13 138618 49 110450619
Unresponsive to stimuli 53.57 27.48 8 138623 63782 110386886
Blepharospasm 53.40 27.48 4 138627 54847 110395821
Cardiac disorder 52.86 27.48 15 138616 76265 110374403
Accidental overdose 52.77 27.48 3 138628 51831 110398837
Breast cancer in situ 52.45 27.48 27 138604 1174 110449494
Cerebrovascular accident 52.13 27.48 92 138539 181192 110269476
Dizziness 52.06 27.48 592 138039 697601 109753067
Tachycardia 51.78 27.48 131 138500 226514 110224154
Blood pressure decreased 51.73 27.48 41 138590 115050 110335618
Pelvic haemorrhage 51.47 27.48 16 138615 175 110450493
Biopsy endometrium 51.15 27.48 9 138622 0 110450668
Fallopian tube perforation 51.15 27.48 9 138622 0 110450668
Ectopic pregnancy under hormonal contraception 51.15 27.48 9 138622 0 110450668
Chlamydial pelvic inflammatory disease 51.15 27.48 9 138622 0 110450668
Cervical discharge 51.15 27.48 9 138622 0 110450668
Haematuria 51.10 27.48 20 138611 82985 110367683
Pregnancy on contraceptive 50.89 27.48 25 138606 983 110449685
Caesarean section 50.79 27.48 74 138557 13743 110436925
Blood bilirubin increased 50.72 27.48 16 138615 75956 110374712
Ventricular tachycardia 50.58 27.48 3 138628 50006 110400662
Colitis ulcerative 50.40 27.48 17 138614 77346 110373322
Therapy interrupted 50.36 27.48 3 138628 49819 110400849
Ear infection 50.15 27.48 9 138622 62723 110387945
Uterine disorder 49.99 27.48 33 138598 2293 110448375
Renal disorder 49.95 27.48 3 138628 49476 110401192
Drug eruption 49.28 27.48 5 138626 53654 110397014
Rash maculo-papular 48.90 27.48 16 138615 74206 110376462
Genito-pelvic pain/penetration disorder 48.56 27.48 9 138622 3 110450665
Intentional device use issue 48.40 27.48 14 138617 117 110450551
Breast discomfort 48.40 27.48 20 138611 520 110450148
Haematemesis 48.30 27.48 8 138623 59100 110391568
Hypophagia 48.09 27.48 5 138626 52621 110398047
Staphylococcal infection 48.01 27.48 14 138617 69930 110380738
Rash pruritic 47.90 27.48 32 138599 98037 110352631
Menopausal symptoms 47.82 27.48 33 138598 2468 110448200
Gonorrhoea 47.56 27.48 16 138615 229 110450439
Clostridium difficile infection 47.51 27.48 5 138626 52124 110398544
Disorientation 46.97 27.48 15 138616 70656 110380012
Adverse drug reaction 46.95 27.48 38 138593 105521 110345147
Hypoaesthesia 46.45 27.48 219 138412 314004 110136664
Cognitive disorder 46.30 27.48 26 138605 87485 110363183
Anaphylactic reaction 46.20 27.48 45 138586 114255 110336413
Pulmonary hypertension 46.20 27.48 7 138624 55213 110395455
Ovarian rupture 46.13 27.48 11 138620 38 110450630
Endometrial atrophy 45.91 27.48 11 138620 39 110450629
Uterine cyst 45.90 27.48 17 138614 327 110450341
Exostosis 45.75 27.48 3 138628 45953 110404715
Mouth ulceration 45.50 27.48 4 138627 48134 110402534
Adnexal torsion 45.45 27.48 18 138613 418 110450250
Sleep disorder 45.23 27.48 115 138516 198529 110252139
Papilloma viral infection 45.14 27.48 30 138601 2108 110448560
Cyst 44.92 27.48 77 138554 16419 110434249
Eosinophilia 44.85 27.48 9 138622 57927 110392741
Transaminases increased 44.80 27.48 12 138619 63378 110387290
Abnormal withdrawal bleeding 44.67 27.48 11 138620 45 110450623
Back injury 44.64 27.48 4 138627 47395 110403273
Drug ineffective for unapproved indication 44.53 27.48 38 138593 102800 110347868
Hypervolaemia 44.43 27.48 5 138626 49455 110401213
Oral candidiasis 44.33 27.48 3 138628 44757 110405911
Haemoptysis 44.24 27.48 17 138614 71337 110379331
Endometrial hypertrophy 43.86 27.48 14 138617 168 110450500
Blood lactate dehydrogenase increased 43.83 27.48 3 138628 44331 110406337
Hypercalcaemia 43.77 27.48 4 138627 46653 110404015
Skin exfoliation 43.62 27.48 28 138603 87623 110363045
Balance disorder 43.61 27.48 49 138582 116511 110334157
Subchorionic haemorrhage 43.57 27.48 14 138617 172 110450496
Sleep disorder due to a general medical condition 42.70 27.48 7 138624 52105 110398563
Urinary retention 42.55 27.48 17 138614 69666 110381002
Coeliac disease 42.47 27.48 3 138628 43184 110407484
Leukocytosis 42.43 27.48 8 138623 53820 110396848
Diverticulitis 42.09 27.48 8 138623 53514 110397154
Therapy cessation 41.67 27.48 4 138627 44853 110405815
Laryngitis 41.55 27.48 3 138628 42408 110408260
Infertility 41.29 27.48 20 138611 762 110449906
Acne cystic 41.27 27.48 21 138610 891 110449777
Crying 41.23 27.48 96 138535 25532 110425136
Lethargy 41.22 27.48 34 138597 93542 110357126
Acute abdomen 41.21 27.48 34 138597 3327 110447341
Hepatocellular injury 41.06 27.48 7 138624 50635 110400033
Chloasma 41.00 27.48 12 138619 105 110450563
Abortion spontaneous incomplete 40.96 27.48 9 138622 19 110450649
Placenta accreta 40.83 27.48 14 138617 213 110450455
Uterine fibrosis 40.40 27.48 10 138621 42 110450626
Endometrial adenocarcinoma 40.13 27.48 23 138608 1240 110449428
Ovarian vein thrombosis 40.11 27.48 11 138620 74 110450594
Toxic shock syndrome streptococcal 40.05 27.48 15 138616 298 110450370
Illness 39.88 27.48 27 138604 82144 110368524
Medical device repositioning 39.78 27.48 7 138624 0 110450668
Ulcer 39.64 27.48 4 138627 43112 110407556
Emotional disorder 39.57 27.48 72 138559 16088 110434580
Localised infection 39.56 27.48 4 138627 43044 110407624
Negative thoughts 39.43 27.48 25 138606 1621 110449047
Breast cyst 39.39 27.48 24 138607 1450 110449218
Pelvic abscess 39.38 27.48 30 138601 2616 110448052
Dysarthria 39.04 27.48 29 138602 84092 110366576
Adrenal insufficiency 38.80 27.48 4 138627 42386 110408282
Bacteraemia 38.80 27.48 4 138627 42386 110408282
Gastritis 38.26 27.48 10 138621 53689 110396979
Accidental exposure to product 38.23 27.48 8 138623 50000 110400668
Hepatic cytolysis 37.82 27.48 11 138620 55042 110395626
Seizure 37.69 27.48 146 138485 221039 110229629
Blood alkaline phosphatase increased 37.63 27.48 21 138610 70914 110379754
Endometrial disorder 37.45 27.48 18 138613 674 110449994
Uterine stenosis 37.29 27.48 7 138624 3 110450665
Myalgia 37.12 27.48 148 138483 222233 110228435
Hepatic steatosis 36.94 27.48 8 138623 48823 110401845
Stevens-Johnson syndrome 36.91 27.48 7 138624 46894 110403774
Blood potassium decreased 36.84 27.48 11 138620 54103 110396565
Drug dependence 36.24 27.48 9 138622 50011 110400657
Lymphopenia 36.23 27.48 4 138627 40166 110410502
Haematoma 36.14 27.48 14 138617 58462 110392206
Flushing 36.04 27.48 47 138584 104689 110345979
Suicide attempt 35.99 27.48 46 138585 103348 110347320
Premature menopause 35.88 27.48 20 138611 1022 110449646
Amniotic cavity infection 35.64 27.48 19 138612 888 110449780
Clostridium difficile colitis 35.61 27.48 6 138625 43772 110406896
Disease recurrence 35.24 27.48 16 138615 60768 110389900
Uterine mass 35.23 27.48 14 138617 328 110450340
Back pain 35.20 27.48 657 137974 370339 110080329
Galactorrhoea 35.00 27.48 34 138597 4121 110446547
Bone pain 34.96 27.48 19 138612 65114 110385554
Hydrosalpinx 34.92 27.48 8 138623 22 110450646
Gout 34.67 27.48 3 138628 36563 110414105
Lupus-like syndrome 34.52 27.48 5 138626 40787 110409881
Haematocrit decreased 34.46 27.48 20 138611 66097 110384571
Liver function test abnormal 34.35 27.48 22 138609 68928 110381740
Hormone receptor positive breast cancer 34.27 27.48 16 138615 561 110450107
Skin lesion 34.24 27.48 11 138620 51620 110399048
Cervical friability 34.10 27.48 6 138625 0 110450668
Chlamydial cervicitis 34.10 27.48 6 138625 0 110450668
Fear of pregnancy 34.10 27.48 6 138625 0 110450668
Inadequate lubrication 34.10 27.48 6 138625 0 110450668
Biopsy cervix 34.10 27.48 6 138625 0 110450668
Hyperlipidaemia 33.82 27.48 3 138628 35845 110414823
Pain in jaw 33.77 27.48 11 138620 51166 110399502
Actinomycosis 33.72 27.48 21 138610 1319 110449349
Adnexa uteri mass 33.72 27.48 15 138616 469 110450199
Angina pectoris 33.69 27.48 18 138613 62277 110388391
Ascites 33.66 27.48 40 138591 92768 110357900
Joint injury 33.62 27.48 5 138626 39989 110410679
High risk pregnancy 33.53 27.48 10 138621 94 110450574
Breast mass 33.47 27.48 46 138585 8095 110442573
Gastric ulcer 33.43 27.48 5 138626 39822 110410846
Perineal pain 33.40 27.48 22 138609 1523 110449145
Medical device site pain 33.28 27.48 14 138617 381 110450287
Pulmonary mass 32.93 27.48 4 138627 37297 110413371
Ovarian enlargement 32.71 27.48 14 138617 398 110450270
Polycystic ovaries 32.67 27.48 35 138596 4761 110445907
Cervix inflammation 32.64 27.48 9 138622 62 110450606
Ectropion of cervix 32.51 27.48 9 138622 63 110450605
Ear pain 32.47 27.48 13 138618 53213 110397455
Viral infection 32.38 27.48 13 138618 53126 110397542
Influenza like illness 32.17 27.48 38 138593 88374 110362294
Injection site bruising 32.14 27.48 12 138619 51251 110399417
Injection site pruritus 32.13 27.48 12 138619 51246 110399422
Pancreatitis acute 31.75 27.48 18 138613 60256 110390412
Genital infection bacterial 31.67 27.48 6 138625 3 110450665
Epilepsy 31.46 27.48 48 138583 100161 110350507
Conjunctivitis 31.42 27.48 3 138628 33789 110416879
Basal cell carcinoma 31.18 27.48 9 138622 45261 110405407
Ovarian abscess 31.11 27.48 10 138621 123 110450545
Angioedema 31.10 27.48 47 138584 98453 110352215
Female sexual dysfunction 30.86 27.48 8 138623 42 110450626
Blood potassium increased 30.79 27.48 3 138628 33246 110417422
Anaphylactic shock 30.78 27.48 13 138618 51533 110399135
Retroplacental haematoma 30.53 27.48 10 138621 131 110450537
Sinus tachycardia 30.37 27.48 9 138622 44484 110406184
Vulvovaginal swelling 30.34 27.48 15 138616 598 110450070
Lymphocyte count decreased 30.29 27.48 17 138614 57226 110393442
Immunodeficiency 30.13 27.48 6 138625 38832 110411836
Nodule 30.07 27.48 3 138628 32628 110418040
Ovarian cystectomy 30.05 27.48 9 138622 86 110450582
Cervix carcinoma 30.04 27.48 25 138606 2476 110448192
Bladder perforation 30.01 27.48 13 138618 381 110450287
Affective disorder 29.99 27.48 52 138579 11189 110439479
Rash erythematous 29.96 27.48 35 138596 81797 110368871
Induced abortion haemorrhage 29.95 27.48 6 138625 6 110450662
Atelectasis 29.93 27.48 5 138626 36707 110413961
Neutrophil count increased 29.90 27.48 4 138627 34648 110416020
Dry skin 29.72 27.48 56 138575 107597 110343071
Weight loss poor 29.70 27.48 20 138611 1437 110449231
Acute hepatic failure 29.66 27.48 5 138626 36463 110414205
Drug withdrawal syndrome 29.27 27.48 6 138625 38048 110412620
Oral herpes 29.22 27.48 5 138626 36075 110414593
Hysteroscopy 29.17 27.48 7 138624 25 110450643
Dyskinesia 29.12 27.48 14 138617 51432 110399236
Injection site swelling 29.06 27.48 21 138610 61769 110388899
Hallucination, visual 28.94 27.48 7 138624 39598 110411070
Rib fracture 28.90 27.48 4 138627 33766 110416902
Skin laceration 28.88 27.48 4 138627 33749 110416919
Osteonecrosis 28.87 27.48 4 138627 33737 110416931
Candida infection 28.84 27.48 12 138619 47997 110402671
Head injury 28.82 27.48 9 138622 43008 110407660
Oral pain 28.60 27.48 6 138625 37438 110413230
Ovulation pain 28.58 27.48 10 138621 162 110450506
Intracranial pressure increased 28.46 27.48 49 138582 10486 110440182
Cervix erythema 28.42 27.48 5 138626 0 110450668
Fallopian tube obstruction 28.42 27.48 5 138626 0 110450668
Premature rupture of membranes 28.40 27.48 32 138599 4605 110446063
Pneumothorax 28.34 27.48 5 138626 35280 110415388
Myositis 28.32 27.48 3 138628 31113 110419555
Maternal exposure before pregnancy 28.30 27.48 40 138591 7225 110443443
Nervousness 28.25 27.48 106 138525 36745 110413923
Swelling face 28.24 27.48 45 138586 92276 110358392
Hypophosphataemia 28.23 27.48 4 138627 33178 110417490
Chemical poisoning 28.03 27.48 10 138621 172 110450496
Respiratory tract congestion 28.02 27.48 3 138628 30854 110419814
Hypothyroidism 27.98 27.48 30 138601 72869 110377799
Dysgeusia 27.77 27.48 28 138603 69957 110380711
Blood sodium decreased 27.56 27.48 7 138624 38312 110412356
Myomectomy 27.52 27.48 6 138625 12 110450656

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03AA06 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA07 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AB03 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, sequential preparations
ATC G03AC03 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens
ATC G03AD01 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Emergency contraceptives
ATC G03FA10 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS AND ESTROGENS IN COMBINATION
Progestogens and estrogens, fixed combinations
ATC G03FA11 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS AND ESTROGENS IN COMBINATION
Progestogens and estrogens, fixed combinations
ATC G03FB01 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS AND ESTROGENS IN COMBINATION
Progestogens and estrogens, sequential preparations
ATC G03FB09 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS AND ESTROGENS IN COMBINATION
Progestogens and estrogens, sequential preparations
FDA CS M0447349 Progesterone Congeners
MeSH PA D000080066 Contraceptive Agents, Hormonal
MeSH PA D003271 Contraceptive Agents, Female
MeSH PA D003278 Contraceptives, Oral, Hormonal
MeSH PA D003280 Contraceptives, Oral, Synthetic
MeSH PA D012102 Reproductive Control Agents
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:49324 female contraceptive drug
CHEBI has role CHEBI:49326 synthetic oral contraceptive
CHEBI has role CHEBI:50779 appetite enhancer
CHEBI has role CHEBI:59826 progestin
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:64951 anti-HBV agent
FDA EPC N0000175602 Progestin
FDA PE N0000175830 Inhibit Ovum Fertilization
FDA EPC N0000175832 Progestin-containing Intrauterine System
CHEBI has role CHEBI:63726 neuroprotective agent

Related Drugs by ATC class:

G03AA Progestogens and estrogens, fixed combinations 17 drugs
chlormadinonedesogestreldienogestdrospirenoneestetrolestradiolethinylestradioletynodiolgestodenelynestrenolmedroxyprogesteronemegestrol acetate show all 17 →
G03AB Progestogens and estrogens, sequential preparations 10 drugs
chlormadinonedesogestreldienogestestradiolethinylestradiolgestodenelynestrenolmegestrol acetatenorethisteronenorgestimate
G03AC Progestogens 9 drugs
desogestreldrospirenoneetonogestrellynestrenolmedroxyprogesteronemegestrol acetatenorethisteronenorgestrienonequingestanol acetate
G03AD Emergency contraceptives 1 drug
ulipristal
G03FA Progestogens and estrogens, fixed combinations 15 drugs
dienogestdrospirenonedydrogesteroneethisteroneetynodiolhydroxyprogesterone caproatelynestrenolmedroxyprogesteronemegestrol acetatemethylestrenolonenorethisteronenorethynodrel show all 15 →
G03FB Progestogens and estrogens, sequential preparations 10 drugs
chlormadinonedesogestreldydrogesteronelynestrenolmedrogestonemedroxyprogesteronemegestrol acetatenomegestrolnorethisteronetrimegestone

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Contraception indication 13197004
Postmenopausal osteoporosis indication 102447009
Menopausal flushing indication 198436008
Dysmenorrhea indication 266599000
Postcoital contraception indication 268463003
Menorrhagia indication 386692008
Controlled ovarian stimulation indication 732970000
Female hypogonadism syndrome off-label use 16041008
Polycystic ovaries off-label use 69878008
Acne vulgaris off-label use 88616000
Endometriosis off-label use 129103003
Heart valve disorder contraindication 368009 DOID:4079
Hyperlipoproteinemia contraindication 3744001 DOID:1168
Hypocalcemia contraindication 5291005
Congenital heart disease contraindication 13213009
Hypercholesterolemia contraindication 13644009
Amenorrhea contraindication 14302001 DOID:13938
Jaundice contraindication 18165001
Myocardial infarction contraindication 22298006 DOID:5844
Puerperal endometritis contraindication 22399000
Diplopia contraindication 24982008
Retinal hemorrhage contraindication 28998008
Streptococcal septicemia contraindication 29577008
Vaginitis contraindication 30800001 DOID:2170
Ectopic pregnancy contraindication 34801009 DOID:0060329
Depressive disorder contraindication 35489007
Chloasma contraindication 36209000
Inflammation of cervix contraindication 37610005 DOID:2568
Migraine contraindication 37796009 DOID:6364
Congenital uterine anomaly contraindication 37849005
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Body fluid retention contraindication 43498006
Thrombosis of retinal vein contraindication 46085004
Humoral hypercalcemia of malignancy contraindication 47709007
Chronic heart failure contraindication 48447003
Dementia contraindication 52448006
Hepatic porphyria contraindication 55056006 DOID:3133
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Hyperlipidemia contraindication 55822004 DOID:1168
Benign mammary dysplasia contraindication 57993004
Obstructive hyperbilirubinemia contraindication 59848001
Thrombophlebitis contraindication 64156001 DOID:3875
Blood coagulation disorder contraindication 64779008 DOID:1247
Intermenstrual bleeding - irregular contraindication 64996003
Miscarriage with sepsis contraindication 67465009
Diabetes mellitus contraindication 73211009 DOID:9351
Cyst of ovary contraindication 79883001
Hyperglycemia contraindication 80394007 DOID:4195
Epilepsy contraindication 84757009 DOID:1826
Human immunodeficiency virus infection contraindication 86406008 DOID:526
Breast lump contraindication 89164003
Kidney disease contraindication 90708001 DOID:557
Leukemia, disease contraindication 93143009 DOID:1240
Malignant neoplasm of liver contraindication 93870000 DOID:3571
Uterine leiomyoma contraindication 95315005 DOID:13223
Neoplasm of endometrium contraindication 123844007 DOID:1380
Neoplasm of liver contraindication 126851005 DOID:3571
Deep venous thrombosis contraindication 128053003
Seizure disorder contraindication 128613002
Bed-ridden contraindication 160685001
Liver function tests abnormal contraindication 166603001
Mammography abnormal contraindication 168750009
Angina pectoris contraindication 194828000
Asthma contraindication 195967001 DOID:2841
Cerebrovascular accident contraindication 230690007
Pulmonary thromboembolism contraindication 233935004
Thrombophilia contraindication 234467004 DOID:2452
Disease of liver contraindication 235856003 DOID:409
Cholestasis of pregnancy contraindication 235888006
Uterine perforation by intrauterine contraceptive device contraindication 236738001
Endometrial carcinoma contraindication 254878006 DOID:2871
Chorea contraindication 271700006
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Hypertriglyceridemia contraindication 302870006
Abnormal uterine bleeding unrelated to menstrual cycle contraindication 312984006
Functional visual loss contraindication 313165001
Malignant tumor of cervix contraindication 363354003 DOID:4362
Malignant tumor of ovary contraindication 363443007 DOID:2394
Thromboembolic disorder contraindication 371039008
Cardiovascular event risk contraindication 395112001
Disorder of coronary artery contraindication 414024009
Obesity contraindication 414916001 DOID:9970
Estrogen receptor positive tumor contraindication 416053008
Porphyria contraindication 418470004
Bacterial vaginosis contraindication 419760006 DOID:3385
Optic disc edema contraindication 423341008 DOID:146
Family history of malignant neoplasm of breast contraindication 429740004
Hypertensive urgency contraindication 443482000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002
Severe Headache Disorder contraindication
Nonspecific Abnormal Papanicolaou Smear of Cervix contraindication
Uterine Scarring contraindication
Major Surgery with Prolonged Post-Operative Immobilization contraindication
Intrauterine Device Insertion with Acute Vaginitis contraindication
Inflammatory Disease of Female Pelvic Organs contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.02MG;0.1MG BALCOLTRA AVION PHARMS N208612 Jan. 9, 2018 RX TABLET ORAL 7838042 June 1, 2027 ADMINISTRATION OF FERROUS BISGLYCINATE TABLETS
0.03MG,0.01MG;0.15MG,N/A SEASONIQUE TEVA BRANDED PHARM N021840 May 25, 2006 RX TABLET ORAL 7855190 Dec. 5, 2028 PREVENTION OF PREGNANCY
0.02MG,0.1MG;0.01MG,N/A LOSEASONIQUE TEVA BRANDED PHARM N022262 Oct. 24, 2008 RX TABLET ORAL 7855190 Dec. 5, 2028 PREVENTION OF PREGNANCY
52MG MIRENA BAYER HLTHCARE N021225 Dec. 6, 2000 RX SYSTEM INTRAUTERINE 11850182 Sept. 14, 2029 A METHOD OF PREVENTING PREGNANCY BY PROVIDING AN INTRAUTERINE SYSTEM (IUS), HOLDING AN INSERTER HANDLE WITH ONE HAND, INSERTING THE IUS INTO THE UTERUS, AND MOVING A SLIDER IN THE HANDLE TO RELEASE THE IUS WITHIN THE UTERUS
13.5MG SKYLA BAYER HLTHCARE N203159 Jan. 9, 2013 RX SYSTEM INTRAUTERINE 11850182 Sept. 14, 2029 A METHOD OF PREVENTING PREGNANCY BY PROVIDING AN INTRAUTERINE SYSTEM (IUS), HOLDING AN INSERTER HANDLE WITH ONE HAND, INSERTING THE IUS INTO THE UTERUS, AND MOVING A SLIDER IN THE HANDLE TO RELEASE THE IUS WITHIN THE UTERUS
19.5MG KYLEENA BAYER HLTHCARE N208224 Sept. 16, 2016 RX SYSTEM INTRAUTERINE 11850182 Sept. 14, 2029 A METHOD OF PREVENTING PREGNANCY BY PROVIDING AN INTRAUTERINE SYSTEM (IUS), HOLDING AN INSERTER HANDLE WITH ONE HAND, INSERTING THE IUS INTO THE UTERUS, AND MOVING A SLIDER IN THE HANDLE TO RELEASE THE IUS WITHIN THE UTERUS
52MG MIRENA BAYER HLTHCARE N021225 Dec. 6, 2000 RX SYSTEM INTRAUTERINE 10561524 Sept. 16, 2029 A METHOD OF POSITIONING AN INTRAUTERINE SYSTEM (IUS) BY DETERMINING A DEPTH OF THE UTERUS, HOLDING AN INSERTER HANDLE WITH ONE HAND, INSERTING THE IUS INTO THE UTERUS, AND RETRACTING A SLIDER ON THE HANDLE TO RELEASE THE IUS INTO THE UTERUS
13.5MG SKYLA BAYER HLTHCARE N203159 Jan. 9, 2013 RX SYSTEM INTRAUTERINE 10561524 Sept. 16, 2029 A METHOD OF POSITIONING AN INTRAUTERINE SYSTEM (IUS) BY DETERMINING A DEPTH OF THE UTERUS, HOLDING AN INSERTER HANDLE WITH ONE HAND, INSERTING THE IUS INTO THE UTERUS, AND RETRACTING A SLIDER ON THE HANDLE TO RELEASE THE IUS INTO THE UTERUS
19.5MG KYLEENA BAYER HLTHCARE N208224 Sept. 16, 2016 RX SYSTEM INTRAUTERINE 10561524 Sept. 16, 2029 A METHOD OF POSITIONING AN INTRAUTERINE SYSTEM (IUS) BY DETERMINING A DEPTH OF THE UTERUS, HOLDING AN INSERTER HANDLE WITH ONE HAND, INSERTING THE IUS INTO THE UTERUS, AND RETRACTING A SLIDER ON THE HANDLE TO RELEASE THE IUS INTO THE UTERUS
52MG LILETTA MEDICINES360 N206229 Feb. 26, 2015 RX SYSTEM INTRAUTERINE 11090186 Oct. 24, 2033 A METHOD FOR PREVENTION OF PREGNANCY
52MG LILETTA MEDICINES360 N206229 Feb. 26, 2015 RX SYSTEM INTRAUTERINE 10028858 March 22, 2034 A METHOD FOR PREVENTION OF PREGNANCY

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
52MG LILETTA MEDICINES360 N206229 Feb. 26, 2015 RX SYSTEM INTRAUTERINE June 29, 2026 TREATMENT OF HEAVY MENSTRUAL BLEEDING FOR UP TO 5 YEARS IN PATIENTS WHO CHOOSE INTRAUTERINE CONTRACEPTION AS THEIR METHOD OF CONTRACEPTION
0.075MG OPILL LABORATOIRE HRA N017031 None OTC TABLET ORAL July 13, 2026 RX TO OTC SWITCH OR OTC USE

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Progesterone receptor Nuclear hormone receptor AGONIST ED50 12.80 WOMBAT-PK CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 6.23 DRUG MATRIX
Glucocorticoid receptor Nuclear hormone receptor Ki 7.17 DRUG MATRIX
Estrogen receptor Nuclear hormone receptor WOMBAT-PK
Sex hormone-binding globulin Secreted Kd 8.91 CHEMBL
Androgen receptor Transcription factor Ki 8.37 DRUG MATRIX
Progesterone receptor Transcription factor Ki 9.34 DRUG MATRIX

External reference:

IDSource
4018027 VUID
N0000146370 NUI
D00950 KEGG_DRUG
6533-00-2 SECONDARY_CAS_RN
4018023 VANDF
4018027 VANDF
C0023566 UMLSCUI
CHEBI:6443 CHEBI
NOG PDB_CHEM_ID
CHEMBL1389 ChEMBL_ID
CHEMBL2107797 ChEMBL_ID
DB00367 DRUGBANK_ID
D016912 MESH_DESCRIPTOR_UI
13109 PUBCHEM_CID
2881 IUPHAR_LIGAND_ID
3475 INN_ID
5W7SIA7YZW UNII
DB09389 DRUGBANK_ID
6373 RXNORM
180470 MMSL
4974 MMSL
5191 MMSL
d00557 MMSL
d03034 MMSL
001303 NDDF
001304 NDDF
001325 NDDF
109032009 SNOMEDCT_US
126106007 SNOMEDCT_US
126109000 SNOMEDCT_US
82240008 SNOMEDCT_US
D009644 MESH_DESCRIPTOR_UI
2157 INN_ID
5W7SIA7YZW INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
LILETTA HUMAN PRESCRIPTION DRUG LABEL 1 0023-5858 INTRAUTERINE DEVICE 52 mg INTRAUTERINE NDA 30 sections
Option 2 HUMAN OTC DRUG LABEL 1 0113-2003 TABLET 1.50 mg ORAL ANDA 14 sections
OPTION 2 HUMAN OTC DRUG LABEL 1 0113-8099 TABLET 1.50 mg ORAL ANDA 14 sections
Opill HUMAN OTC DRUG LABEL 1 0113-8101 TABLET 0.08 mg ORAL NDA 16 sections
NORGESTREL HUMAN OTC DRUG LABEL 1 0363-5510 TABLET 0.08 mg ORAL NDA 16 sections
Amethyst HUMAN PRESCRIPTION DRUG LABEL 2 0480-3472 TABLET 90 ug ORAL ANDA 24 sections
Levonorgestrel Human OTC Drug Label 1 0536-1433 TABLET 1.50 mg ORAL ANDA 14 sections
New Day HUMAN OTC DRUG LABEL 1 16714-809 TABLET 1.50 mg ORAL ANDA 12 sections
NEXT CHOICE HUMAN PRESCRIPTION DRUG LABEL 1 21695-443 TABLET 0.75 mg ORAL ANDA 14 sections
Plan B One-Step HUMAN PRESCRIPTION DRUG LABEL 1 21695-973 TABLET 1.50 mg ORAL NDA 25 sections
Levonorgestrel HUMAN PRESCRIPTION DRUG LABEL 1 40032-620 TABLET 1.50 mg ORAL ANDA 24 sections
Levonorgestrel HUMAN PRESCRIPTION DRUG LABEL 1 40032-622 TABLET 1.50 mg ORAL ANDA 8 sections
My Way HUMAN PRESCRIPTION DRUG LABEL 1 43386-620 TABLET 1.50 mg ORAL ANDA 24 sections
My Way HUMAN OTC DRUG LABEL 1 43386-622 TABLET 1.50 mg ORAL ANDA 12 sections
Levonorgestrel HUMAN OTC DRUG LABEL 1 49615-017 TABLET 1.50 mg ORAL ANDA 13 sections
Plan B One-Step HUMAN OTC DRUG LABEL 1 50090-1141 TABLET 1.50 mg ORAL NDA 14 sections
Plan B One-Step HUMAN OTC DRUG LABEL 1 50090-5978 TABLET 1.50 mg ORAL NDA 15 sections
EContra One-Step Human OTC Drug Label 1 50102-211 TABLET 1.50 mg ORAL ANDA 14 sections
Skyla HUMAN PRESCRIPTION DRUG LABEL 1 50419-422 INTRAUTERINE DEVICE 13.50 mg INTRAUTERINE NDA 29 sections
Mirena HUMAN PRESCRIPTION DRUG LABEL 1 50419-423 INTRAUTERINE DEVICE 52 mg INTRAUTERINE NDA 28 sections
Mirena HUMAN PRESCRIPTION DRUG LABEL 1 50419-423 INTRAUTERINE DEVICE 52 mg INTRAUTERINE NDA 28 sections
Kyleena HUMAN PRESCRIPTION DRUG LABEL 1 50419-424 INTRAUTERINE DEVICE 19.50 mg INTRAUTERINE NDA 29 sections
Kyleena HUMAN PRESCRIPTION DRUG LABEL 1 50419-424 INTRAUTERINE DEVICE 19.50 mg INTRAUTERINE NDA 29 sections
Climara Pro HUMAN PRESCRIPTION DRUG LABEL 2 50419-491 PATCH 0.02 mg TRANSDERMAL NDA 33 sections
Her Style HUMAN OTC DRUG LABEL 1 50742-352 TABLET 1.50 mg ORAL ANDA 10 sections
Dolishale HUMAN PRESCRIPTION DRUG LABEL 2 50742-659 TABLET 90 ug ORAL ANDA 15 sections
My Choice HUMAN OTC DRUG LABEL 1 51660-096 TABLET 1.50 mg ORAL ANDA 14 sections
Levonorgestrel HUMAN OTC DRUG LABEL 1 51660-723 TABLET 1.50 mg ORAL ANDA 14 sections
Levonorgestrel HUMAN OTC DRUG LABEL 1 51660-999 TABLET 1.50 mg ORAL ANDA 15 sections
Next Choice HUMAN PRESCRIPTION DRUG LABEL 1 52959-450 TABLET 0.75 mg ORAL ANDA 24 sections