ethinylestradiol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
estrogens 1082 57-63-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ethinylestradiol betadex
  • ethynyl estradiol
  • ethinylestradiol
  • ethinyl estradiol
  • 17-ethinylestradiol
  • ethinyloestradiol
A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.
  • Molecular weight: 296.41
  • Formula: C20H24O2
  • CLOGP: 3.68
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -4.64
  • ROTB: 0

Drug dosage:

DoseUnitRoute
25 mcg O
1.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 3 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.10 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 40 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 25, 1943 FDA SCHERING

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pulmonary embolism 2307.16 10.74 1639 69173 106946 46508304
Deep vein thrombosis 1418.21 10.74 1083 69729 78690 46536560
Inappropriate schedule of product administration 1337.77 10.74 964 69848 64049 46551201
Unintended pregnancy 1173.24 10.74 407 70405 5253 46609997
No adverse event 1075.16 10.74 661 70151 33570 46581680
Incorrect product administration duration 1056.11 10.74 434 70378 9143 46606107
Device expulsion 1008.16 10.74 587 70225 26955 46588295
Product quality issue 701.33 10.74 515 70297 35133 46580117
Pregnancy with contraceptive device 565.00 10.74 224 70588 4279 46610971
Pregnancy on oral contraceptive 506.69 10.74 152 70660 1182 46614068
Injury 478.27 10.74 451 70361 43576 46571674
Abnormal withdrawal bleeding 385.15 10.74 85 70727 138 46615112
Cerebral venous thrombosis 379.92 10.74 137 70675 1990 46613260
Device breakage 379.46 10.74 216 70596 9476 46605774
Menstruation irregular 348.97 10.74 179 70633 6360 46608890
Death 337.54 10.74 53 70759 335495 46279755
Cerebral venous sinus thrombosis 320.17 10.74 116 70696 1709 46613541
Vaginal haemorrhage 316.34 10.74 282 70530 25322 46589928
Medical device discomfort 284.19 10.74 109 70703 1897 46613353
Embolism arterial 273.61 10.74 92 70720 1071 46614179
Dysmenorrhoea 270.84 10.74 124 70688 3414 46611836
Product storage error 260.64 10.74 183 70629 11609 46603641
Menstruation delayed 243.81 10.74 92 70720 1528 46613722
Maternal exposure before pregnancy 242.97 10.74 124 70688 4357 46610893
Medical device site discomfort 228.07 10.74 60 70752 268 46614982
Emotional distress 223.73 10.74 254 70558 30453 46584797
Withdrawal bleed 223.39 10.74 49 70763 76 46615174
Migraine 218.86 10.74 386 70426 69640 46545610
Abortion induced 216.98 10.74 155 70657 10105 46605145
Pregnancy on contraceptive 211.66 10.74 75 70737 1032 46614218
Intentional medical device removal by patient 209.22 10.74 53 70759 197 46615053
Vaginal discharge 204.05 10.74 113 70699 4695 46610555
Anxiety 201.33 10.74 670 70142 181287 46433963
Uterine perforation 199.45 10.74 129 70683 7138 46608112
Acute kidney injury 193.04 10.74 59 70753 235796 46379454
Completed suicide 190.48 10.74 7 70805 145913 46469337
Amenorrhoea 182.65 10.74 132 70680 8763 46606487
Pulmonary infarction 180.86 10.74 86 70726 2585 46612665
Toxicity to various agents 178.72 10.74 50 70762 211716 46403534
Thrombosis 175.06 10.74 309 70503 55760 46559490
Vulvovaginal discomfort 170.40 10.74 78 70734 2146 46613104
Fall 157.94 10.74 160 70652 328937 46286313
Hypercoagulation 155.18 10.74 71 70741 1951 46613299
Abortion spontaneous 153.99 10.74 254 70558 43392 46571858
Pelvic venous thrombosis 151.28 10.74 65 70747 1532 46613718
Pelvic pain 145.66 10.74 129 70683 11473 46603777
Menstrual disorder 144.86 10.74 86 70726 4082 46611168
Product substitution issue 140.64 10.74 142 70670 14889 46600361
Thrombophlebitis superficial 140.22 10.74 90 70722 4913 46610337
Product shape issue 139.25 10.74 35 70777 125 46615125
Transverse sinus thrombosis 133.55 10.74 47 70765 633 46614617
Vena cava filter insertion 129.48 10.74 35 70777 177 46615073
Rheumatoid arthritis 121.87 10.74 111 70701 240104 46375146
Muscle injury 120.46 10.74 81 70731 4785 46610465
Folliculitis 118.20 10.74 88 70724 6115 46609135
Neutropenia 116.74 10.74 36 70776 143168 46472082
Cervical dysplasia 113.05 10.74 65 70747 2904 46612346
Pneumonia 111.03 10.74 255 70557 376065 46239185
Hypotension 110.41 10.74 114 70698 232475 46382775
Chlamydial infection 109.83 10.74 34 70778 297 46614953
Embolism venous 109.35 10.74 60 70752 2447 46612803
Anaemia 107.76 10.74 138 70674 255641 46359609
Sepsis 107.66 10.74 36 70776 135978 46479272
Depression 104.34 10.74 522 70290 169582 46445668
Gastrointestinal haemorrhage 103.45 10.74 3 70809 77370 46537880
Superior sagittal sinus thrombosis 101.77 10.74 41 70771 817 46614433
Headache 101.43 10.74 1139 69673 477213 46138037
Acne 98.89 10.74 136 70676 19783 46595467
Cardiac failure congestive 95.46 10.74 13 70799 91737 46523513
Product colour issue 94.46 10.74 36 70776 615 46614635
Febrile neutropenia 90.37 10.74 17 70795 94610 46520640
Renal failure 90.00 10.74 30 70782 113564 46501686
Pancytopenia 88.61 10.74 12 70800 85046 46530204
Genital haemorrhage 88.44 10.74 76 70736 6490 46608760
Mood swings 88.37 10.74 116 70696 16136 46599114
Drug hypersensitivity 86.63 10.74 148 70664 243677 46371573
Atrial fibrillation 86.29 10.74 25 70787 103565 46511685
Abdominal pain lower 85.32 10.74 131 70681 21050 46594200
Hepatic adenoma 82.58 10.74 27 70785 286 46614964
Hyponatraemia 81.61 10.74 26 70786 101306 46513944
Irritable bowel syndrome 80.84 10.74 112 70700 16403 46598847
Dyspareunia 80.50 10.74 48 70764 2296 46612954
Vulvovaginal mycotic infection 79.06 10.74 60 70752 4291 46610959
Malignant neoplasm progression 78.64 10.74 5 70807 64921 46550329
Poor quality product administered 76.68 10.74 51 70761 2958 46612292
Cerebrovascular accident 75.82 10.74 329 70483 100710 46514540
Disease progression 74.29 10.74 23 70789 91277 46523973
Thrombocytopenia 73.53 10.74 51 70761 126530 46488720
Respiratory failure 73.44 10.74 26 70786 94790 46520460
Cerebral thrombosis 72.19 10.74 40 70772 1663 46613587
Hypermobility syndrome 72.19 10.74 30 70782 649 46614601
Thrombectomy 70.13 10.74 21 70791 162 46615088
Product dose omission issue 69.78 10.74 466 70346 168054 46447196
Platelet count decreased 68.47 10.74 33 70779 99991 46515259
Haemoglobin decreased 68.44 10.74 57 70755 128892 46486358
Vulvovaginal pain 68.30 10.74 42 70770 2125 46613125
Chronic obstructive pulmonary disease 68.16 10.74 5 70807 57628 46557622
Diarrhoea 67.57 10.74 535 70277 559067 46056183
Sleep disorder due to general medical condition, insomnia type 67.15 10.74 59 70753 5190 46610060
Hypomenorrhoea 66.41 10.74 26 70786 479 46614771
Treatment failure 66.38 10.74 29 70783 93058 46522192
Polymenorrhoea 65.35 10.74 33 70779 1133 46614117
Decreased appetite 64.91 10.74 122 70690 193714 46421536
Neuropathy peripheral 63.74 10.74 29 70783 90864 46524386
Renal impairment 63.70 10.74 17 70795 74355 46540895
Cardiac failure 61.78 10.74 22 70790 79926 46535324
Device difficult to use 61.33 10.74 68 70744 7936 46607314
Thalamic infarction 61.06 10.74 25 70787 520 46614730
Product use in unapproved indication 60.27 10.74 284 70528 89989 46525261
Leukopenia 59.72 10.74 15 70797 68328 46546922
Night sweats 59.21 10.74 129 70683 27121 46588129
Oedema peripheral 58.47 10.74 95 70717 159611 46455639
Menstruation normal 58.33 10.74 17 70795 118 46615132
Muscle spasticity 58.12 10.74 79 70733 11361 46603889
Product adhesion issue 58.06 10.74 53 70759 4902 46610348
Interstitial lung disease 57.66 10.74 7 70805 53942 46561308
Congenital cyst 57.56 10.74 14 70798 42 46615208
Pregnancy with contraceptive patch 56.84 10.74 13 70799 27 46615223
Ovarian cyst 56.55 10.74 87 70725 14000 46601250
Meningioma 56.44 10.74 45 70767 3460 46611790
Septic shock 56.13 10.74 10 70802 57883 46557367
Vena cava thrombosis 55.69 10.74 37 70775 2142 46613108
Plasma cell myeloma 55.15 10.74 3 70809 44475 46570775
Tension 55.03 10.74 41 70771 2851 46612399
Blood creatinine increased 54.16 10.74 24 70788 76379 46538871
Ectopic pregnancy 52.28 10.74 38 70774 2544 46612706
Dehydration 52.01 10.74 102 70710 159438 46455812
Anhedonia 51.95 10.74 71 70741 10264 46604986
Accidental underdose 51.55 10.74 23 70789 595 46614655
Venous thrombosis limb 50.96 10.74 39 70773 2824 46612426
Sinusitis 49.62 10.74 352 70460 129416 46485834
Poor quality device used 49.52 10.74 34 70778 2078 46613172
Anticonvulsant drug level decreased 49.42 10.74 28 70784 1216 46614034
Ischaemic stroke 49.38 10.74 90 70722 16632 46598618
Thrombophlebitis 49.16 10.74 46 70766 4391 46610859
Drug intolerance 48.81 10.74 93 70719 146956 46468294
White blood cell count decreased 48.80 10.74 59 70753 112172 46503078
Smear cervix abnormal 48.62 10.74 36 70776 2480 46612770
Cataract 48.27 10.74 6 70806 45409 46569841
Mesenteric vein thrombosis 48.07 10.74 24 70788 804 46614446
Protein S deficiency 47.93 10.74 12 70800 42 46615208
Vaginal infection 47.09 10.74 52 70760 6041 46609209
Osteoarthritis 46.35 10.74 18 70794 62007 46553243
Device failure 46.30 10.74 51 70761 5908 46609342
Endometriosis 46.16 10.74 42 70770 3868 46611382
Uterine leiomyoma 45.88 10.74 59 70753 8040 46607210
Venous thrombosis 44.56 10.74 45 70767 4717 46610533
Hyperkalaemia 44.55 10.74 11 70801 50698 46564552
Coagulopathy 44.15 10.74 91 70721 18408 46596842
Post thrombotic syndrome 43.69 10.74 20 70792 550 46614700
Cerebral infarction 43.43 10.74 104 70708 23262 46591988
Breast tenderness 43.27 10.74 32 70780 2200 46613050
Internal injury 42.70 10.74 18 70794 404 46614846
Cough 42.55 10.74 192 70620 230057 46385193
Hypoxia 42.26 10.74 13 70799 51825 46563425
Venous stent insertion 41.83 10.74 9 70803 12 46615238
May-Thurner syndrome 41.62 10.74 10 70802 28 46615222
Device dislocation 41.56 10.74 98 70714 21704 46593546
Libido decreased 41.00 10.74 33 70779 2572 46612678
Therapeutic product effect incomplete 40.89 10.74 35 70777 78118 46537132
Panic attack 40.80 10.74 93 70719 20149 46595101
Vulvovaginal burning sensation 40.70 10.74 27 70785 1559 46613691
Device issue 40.50 10.74 92 70720 19888 46595362
Bacterial vaginosis 40.25 10.74 22 70790 890 46614360
Lactic acidosis 39.92 10.74 3 70809 33906 46581344
Herpes zoster 39.85 10.74 27 70785 67845 46547405
Tonsillectomy 39.77 10.74 21 70791 792 46614458
Papilloma viral infection 39.50 10.74 25 70787 1331 46613919
Thrombolysis 39.40 10.74 11 70801 64 46615186
Malaise 39.21 10.74 318 70494 330914 46284336
Drug abuse 38.90 10.74 24 70788 63384 46551866
Multiple organ dysfunction syndrome 38.65 10.74 15 70797 51695 46563555
Anticoagulation drug level below therapeutic 38.58 10.74 20 70792 726 46614524
Product packaging quantity issue 38.18 10.74 23 70789 1121 46614129
Cholecystectomy 37.93 10.74 57 70755 8985 46606265
Osteonecrosis of jaw 37.92 10.74 4 70808 34398 46580852
Vulvovaginal swelling 37.39 10.74 17 70795 460 46614790
Coma 37.33 10.74 21 70791 58328 46556922
Hyperkaliuria 37.09 10.74 10 70802 50 46615200
Rhabdomyolysis 36.99 10.74 9 70803 41900 46573350
Colposcopy 36.75 10.74 9 70803 28 46615222
Female sterilisation 36.75 10.74 18 70794 578 46614672
Polycystic ovaries 36.58 10.74 24 70788 1360 46613890
Ear pain 36.50 10.74 94 70718 21998 46593252
Pyrexia 36.36 10.74 346 70466 348456 46266794
Product physical issue 36.27 10.74 41 70771 4886 46610364
Jugular vein thrombosis 36.15 10.74 31 70781 2639 46612611
Overdose 36.06 10.74 62 70750 101917 46513333
Bone pain 36.05 10.74 13 70799 46877 46568373
Hyperaldosteronism 35.51 10.74 14 70798 263 46614987
Body temperature increased 35.27 10.74 100 70712 24761 46590489
Oedema 35.13 10.74 30 70782 67041 46548209
Electrocardiogram QT prolonged 35.01 10.74 17 70795 51308 46563942
Exposure during pregnancy 34.86 10.74 282 70530 107930 46507320
Premenstrual syndrome 34.68 10.74 18 70794 655 46614595
Femur fracture 34.56 10.74 7 70805 36990 46578260
Adverse event 34.28 10.74 122 70690 34062 46581188
Recalled product administered 33.95 10.74 13 70799 225 46615025
Embedded device 33.79 10.74 31 70781 2885 46612365
Antiphospholipid antibodies positive 33.65 10.74 17 70795 584 46614666
Uterine haemorrhage 33.51 10.74 34 70778 3583 46611667
Mood altered 33.44 10.74 66 70746 12941 46602309
Maternal exposure during pregnancy 33.44 10.74 268 70544 102281 46512969
Ankylosing spondylitis 33.43 10.74 46 70766 6691 46608559
Application site rash 32.98 10.74 29 70783 2553 46612697
Oxygen saturation decreased 32.63 10.74 34 70778 69130 46546120
Myocardial infarction 32.07 10.74 62 70750 97466 46517784
Mental status changes 32.05 10.74 9 70803 38079 46577171
Chronic kidney disease 31.99 10.74 11 70801 40860 46574390
Medical device pain 31.86 10.74 23 70789 1523 46613727
Coital bleeding 31.20 10.74 15 70797 462 46614788
Cardio-respiratory arrest 31.09 10.74 27 70785 59842 46555408
Emotional disorder 31.04 10.74 62 70750 12262 46602988
Complication of device removal 30.88 10.74 32 70780 3458 46611792
Lower respiratory tract infection 30.87 10.74 165 70647 54924 46560326
Abdominal pain 30.81 10.74 505 70307 229526 46385724
Product packaging issue 30.62 10.74 19 70793 977 46614273
Depressed level of consciousness 30.60 10.74 17 70795 47552 46567698
Weight decreased 30.48 10.74 191 70621 210658 46404592
Epilepsy 30.34 10.74 92 70720 23646 46591604
Abortion 30.21 10.74 26 70786 2224 46613026
Arthritis 30.18 10.74 44 70768 77272 46537978
Hypoglycaemia 30.10 10.74 23 70789 54326 46560924
Complication associated with device 30.08 10.74 70 70742 15371 46599879
Loss of libido 29.95 10.74 21 70791 1328 46613922
Carotid artery dissection 29.93 10.74 11 70801 169 46615081
Mucosal inflammation 29.64 10.74 11 70801 38965 46576285
Metabolic acidosis 29.39 10.74 11 70801 38769 46576481
Oligomenorrhoea 28.79 10.74 16 70796 669 46614581
Ectopic pregnancy under hormonal contraception 28.78 10.74 7 70805 21 46615229
Weight increased 28.67 10.74 378 70434 164095 46451155
Peripheral artery thrombosis 28.65 10.74 23 70789 1786 46613464
Skin ulcer 28.59 10.74 7 70805 32451 46582799
Suicidal ideation 28.35 10.74 164 70648 56218 46559032
Drug ineffective 28.30 10.74 798 70014 677040 45938210
Pregnancy 28.20 10.74 98 70714 27039 46588211
Protein S decreased 27.90 10.74 8 70804 52 46615198
Hemiparesis 27.76 10.74 80 70732 19989 46595261
Intentional overdose 27.32 10.74 35 70777 64909 46550341
Hip fracture 27.05 10.74 4 70808 26552 46588698
Menometrorrhagia 27.02 10.74 17 70795 896 46614354
Asthenia 26.96 10.74 322 70490 310753 46304497
Respiratory arrest 26.64 10.74 9 70803 33807 46581443
Fear of disease 26.60 10.74 18 70794 1074 46614176
Breast pain 26.50 10.74 44 70768 7550 46607700
Muscle spasms 26.26 10.74 294 70518 122819 46492431
Polyarteritis nodosa 25.95 10.74 12 70800 338 46614912
Neutrophil count decreased 25.86 10.74 17 70795 43409 46571841
Blood pressure systolic increased 25.77 10.74 6 70806 28781 46586469
Discomfort 25.62 10.74 139 70673 46531 46568719
Bradycardia 25.61 10.74 38 70774 66260 46548990
Factor V Leiden mutation 25.59 10.74 9 70803 121 46615129
Blood urea increased 25.41 10.74 4 70808 25348 46589902
Pre-existing condition improved 25.37 10.74 40 70772 6572 46608678
Hypocalcaemia 25.16 10.74 5 70807 26780 46588470
Neoplasm progression 25.03 10.74 5 70807 26678 46588572
Ill-defined disorder 24.58 10.74 93 70719 26734 46588516
Decidual cast 24.53 10.74 5 70807 4 46615246
International normalised ratio increased 24.51 10.74 21 70791 46862 46568388
Pregnancy with implant contraceptive 24.51 10.74 22 70790 1990 46613260
Uterine dilation and curettage 24.48 10.74 16 70796 901 46614349
Melaena 24.44 10.74 6 70806 27766 46587484
Delirium 24.39 10.74 13 70799 37215 46578035
Fluid retention 24.18 10.74 25 70787 51021 46564229
Fibrin D dimer increased 24.18 10.74 30 70782 3943 46611307
Osteoporosis 24.04 10.74 16 70796 40592 46574658
Solid pseudopapillary tumour of the pancreas 24.01 10.74 5 70807 5 46615245
Ovarian cyst ruptured 23.95 10.74 17 70795 1096 46614154
Pelvic inflammatory disease 23.90 10.74 20 70792 1646 46613604
Pneumonia aspiration 23.89 10.74 9 70803 31596 46583654
Urine leukocyte esterase positive 23.80 10.74 24 70788 2511 46612739
Osteonecrosis 23.78 10.74 5 70807 25739 46589511
Migraine with aura 23.71 10.74 22 70790 2077 46613173
Bacterial vulvovaginitis 23.69 10.74 13 70799 530 46614720
Ovarian vein thrombosis 23.61 10.74 7 70805 52 46615198
Toxic epidermal necrolysis 23.53 10.74 3 70809 22275 46592975
Blood glucose increased 23.48 10.74 46 70766 71967 46543283
Vulvovaginal injury 23.46 10.74 11 70801 320 46614930
Full blood count decreased 23.44 10.74 3 70809 22208 46593042
Agranulocytosis 23.40 10.74 3 70809 22182 46593068
Peliosis hepatis 23.38 10.74 7 70805 54 46615196
Cervix carcinoma stage 0 23.24 10.74 11 70801 327 46614923
Pulmonary oedema 23.13 10.74 26 70786 51079 46564171
Gait disturbance 22.87 10.74 128 70684 145135 46470115
Blood sodium decreased 22.77 10.74 3 70809 21723 46593527
Vena cava filter removal 22.70 10.74 5 70807 8 46615242
Portal vein thrombosis 22.51 10.74 23 70789 2444 46612806
Peripheral swelling 22.25 10.74 350 70462 157721 46457529
Protein C deficiency 22.25 10.74 6 70806 30 46615220
Urticaria 22.25 10.74 275 70537 117617 46497633
Wisdom teeth removal 22.24 10.74 12 70800 473 46614777
Cor pulmonale acute 22.02 10.74 11 70801 369 46614881
Complication of device insertion 21.93 10.74 32 70780 4912 46610338
Gluten sensitivity 21.85 10.74 12 70800 490 46614760
Fluid overload 21.83 10.74 7 70805 27178 46588072
Blood alkaline phosphatase increased 21.63 10.74 17 70795 39592 46575658
Breast enlargement 21.54 10.74 18 70794 1479 46613771
Haemorrhagic infarction 21.48 10.74 10 70802 286 46614964
Chloasma 21.48 10.74 6 70806 35 46615215
Hormone level abnormal 21.48 10.74 21 70791 2117 46613133
Fungal infection 21.25 10.74 95 70717 29425 46585825
Intracranial pressure increased 21.22 10.74 29 70783 4191 46611059
Knee arthroplasty 21.05 10.74 5 70807 23660 46591590
Aspartate aminotransferase increased 21.01 10.74 56 70756 78644 46536606
Neoplasm malignant 20.83 10.74 5 70807 23494 46591756
Medical device site pain 20.64 10.74 9 70803 220 46615030
Hyperglycaemia 20.52 10.74 14 70798 35057 46580193
Haemorrhage 20.45 10.74 148 70664 54721 46560529
Idiopathic intracranial hypertension 20.41 10.74 22 70790 2487 46612763
Hypokalaemia 20.35 10.74 67 70745 87957 46527293
Cellulitis 20.33 10.74 48 70764 70240 46545010
Cardiac disorder 20.19 10.74 22 70790 43836 46571414
Sopor 20.16 10.74 3 70809 19825 46595425
Toxic shock syndrome 20.08 10.74 11 70801 447 46614803
Pneumonitis 20.02 10.74 9 70803 28411 46586839
Creatinine urine decreased 19.88 10.74 8 70804 159 46615091
Vertebral artery dissection 19.83 10.74 8 70804 160 46615090
Ligament sprain 19.74 10.74 47 70765 10472 46604778
Epiploic appendagitis 19.74 10.74 6 70806 49 46615201
Pleuritic pain 19.54 10.74 35 70777 6381 46608869
Maternal exposure timing unspecified 19.50 10.74 17 70795 1480 46613770
Therapeutic response unexpected 19.46 10.74 60 70752 15556 46599694
Cardiac arrest 19.42 10.74 71 70741 90328 46524922
Disturbance in attention 19.39 10.74 97 70715 31463 46583787
Infertility female 19.34 10.74 12 70800 617 46614633
Agitation 19.30 10.74 34 70778 55381 46559869
Arthralgia 19.29 10.74 414 70398 364189 46251061
Product use issue 19.27 10.74 224 70588 94420 46520830
Coronary artery disease 19.05 10.74 14 70798 33738 46581512
Hallucination 18.93 10.74 29 70783 49922 46565328
Expired product administered 18.85 10.74 32 70780 5590 46609660
Abortion missed 18.78 10.74 17 70795 1555 46613695
Product administration error 18.68 10.74 69 70743 19612 46595638
Confusional state 18.64 10.74 154 70658 159738 46455512
Product blister packaging issue 18.56 10.74 8 70804 190 46615060
Phlebitis 18.51 10.74 33 70779 5993 46609257
Dysphagia 18.46 10.74 58 70754 77254 46537996
Drug reaction with eosinophilia and systemic symptoms 18.37 10.74 11 70801 29537 46585713
Pulmonary fibrosis 18.36 10.74 4 70808 20088 46595162
Bone disorder 18.28 10.74 4 70808 20029 46595221
Diverticulitis 18.27 10.74 14 70798 33025 46582225
Circumstance or information capable of leading to medication error 18.24 10.74 23 70789 3073 46612177
Ectropion of cervix 18.23 10.74 6 70806 65 46615185
Cervicitis 18.11 10.74 10 70802 413 46614837
Vulvovaginal candidiasis 17.93 10.74 21 70791 2600 46612650
Inflammation 17.84 10.74 29 70783 48752 46566498
Urine abnormality 17.66 10.74 31 70781 5563 46609687
Tonsillitis 17.64 10.74 29 70783 4935 46610315
Liver function test abnormal 17.61 10.74 27 70785 46460 46568790
Abortion induced complete 17.59 10.74 4 70808 8 46615242
Attention deficit hyperactivity disorder 17.59 10.74 19 70793 2153 46613097
Blood count abnormal 17.52 10.74 3 70809 17875 46597375
Anembryonic gestation 17.51 10.74 11 70801 578 46614672
Hemianaesthesia 17.49 10.74 10 70802 442 46614808
Synovitis 17.43 10.74 42 70770 61033 46554217
Psychological trauma 17.36 10.74 14 70798 1094 46614156
Hypomagnesaemia 17.34 10.74 6 70806 22204 46593046
Lethargy 17.28 10.74 32 70780 51139 46564111
Product prescribing issue 17.26 10.74 13 70799 919 46614331
Failed induction of labour 17.13 10.74 9 70803 336 46614914
Dysphonia 16.89 10.74 20 70792 38394 46576856
Labelled drug-disease interaction medication error 16.86 10.74 7 70805 151 46615099
Haematocrit decreased 16.80 10.74 17 70795 35040 46580210
Histiocytic necrotising lymphadenitis 16.76 10.74 5 70807 38 46615212
Paradoxical embolism 16.76 10.74 5 70807 38 46615212
Hypophagia 16.74 10.74 12 70800 29294 46585956
Transferrin increased 16.70 10.74 4 70808 11 46615239
Transferrin saturation increased 16.65 10.74 5 70807 39 46615211
Arthropathy 16.61 10.74 69 70743 84631 46530619
Loop electrosurgical excision procedure 16.54 10.74 5 70807 40 46615210
High risk pregnancy 16.53 10.74 7 70805 159 46615091
Ovarian atrophy 16.52 10.74 6 70806 89 46615161
Post-tussive vomiting 16.48 10.74 3 70809 0 46615250
Otorhinolaryngological surgery 16.48 10.74 3 70809 0 46615250
Adenomyosis 16.48 10.74 10 70802 494 46614756
Threatened labour 16.43 10.74 12 70800 809 46614441
Cerebral artery thrombosis 16.33 10.74 9 70803 370 46614880
Constipation 16.31 10.74 177 70635 173920 46441330
Hospitalisation 16.25 10.74 46 70766 63339 46551911
Post-traumatic stress disorder 16.24 10.74 25 70787 4023 46611227
Respiratory disorder 16.14 10.74 83 70729 27217 46588033
Ascites 16.14 10.74 19 70793 36565 46578685
Autoimmune dermatitis 15.83 10.74 5 70807 47 46615203
Endometrial ablation 15.78 10.74 11 70801 689 46614561
Antiphospholipid syndrome 15.69 10.74 16 70796 1696 46613554
Pain 15.62 10.74 878 69934 476070 46139180
Lung disorder 15.60 10.74 26 70786 43278 46571972
Blood potassium decreased 15.51 10.74 21 70791 38042 46577208
Therapy non-responder 15.49 10.74 24 70788 41128 46574122
Stevens-Johnson syndrome 15.46 10.74 8 70804 23289 46591961
Pleural effusion 15.39 10.74 69 70743 82883 46532367
Encephalopathy 15.30 10.74 17 70795 33572 46581678
Mammoplasty 15.08 10.74 9 70803 431 46614819
Infusion site scar 15.01 10.74 7 70805 201 46615049
Wheezing 15.01 10.74 37 70775 53349 46561901
Aphasia 14.95 10.74 84 70728 28483 46586767
Myocardial strain 14.92 10.74 6 70806 119 46615131
Gastrointestinal disorder 14.92 10.74 147 70665 59429 46555821
Liposuction 14.83 10.74 4 70808 20 46615230
Autoinflammatory disease 14.81 10.74 5 70807 59 46615191
Focal nodular hyperplasia 14.80 10.74 9 70803 446 46614804
Hypoaesthesia 14.80 10.74 258 70554 118611 46496639
Haemorrhagic cerebral infarction 14.79 10.74 10 70802 596 46614654
Acute myeloid leukaemia 14.71 10.74 3 70809 15775 46599475
Psoriasis 14.67 10.74 183 70629 78421 46536829
Drug eruption 14.64 10.74 7 70805 21322 46593928
Therapeutic response decreased 14.55 10.74 27 70785 43118 46572132
Pregnancy test positive 14.51 10.74 6 70806 128 46615122
Bipolar disorder 14.49 10.74 33 70779 7144 46608106
Migrainous infarction 14.40 10.74 3 70809 3 46615247
Pelvic congestion 14.40 10.74 3 70809 3 46615247
Hirsutism 14.40 10.74 12 70800 982 46614268
Tension headache 14.40 10.74 19 70793 2655 46612595
Generalised anxiety disorder 14.29 10.74 15 70797 1645 46613605
Anger 14.27 10.74 45 70767 11807 46603443
Urosepsis 14.14 10.74 3 70809 15350 46599900
Vulvovaginal pruritus 14.13 10.74 18 70794 2429 46612821
Device physical property issue 14.12 10.74 14 70798 1435 46613815
Spinal fracture 14.08 10.74 3 70809 15302 46599948
Application site erythema 13.98 10.74 26 70786 4878 46610372
Rash maculo-papular 13.95 10.74 13 70799 27861 46587389
C-reactive protein increased 13.95 10.74 44 70768 58546 46556704
Ligament injury 13.94 10.74 12 70800 1027 46614223
Hemianopia homonymous 13.92 10.74 10 70802 657 46614593
Fibroadenoma of breast 13.88 10.74 8 70804 359 46614891
Fatigue 13.84 10.74 769 70043 607928 46007322
Emergency care examination 13.84 10.74 5 70807 73 46615177
Mental disorder 13.83 10.74 69 70743 22356 46592894
Musculoskeletal pain 13.83 10.74 57 70755 70071 46545179
Faecal volume decreased 13.82 10.74 6 70806 145 46615105
Vitamin B12 deficiency 13.81 10.74 23 70789 3956 46611294
Blood creatine phosphokinase increased 13.80 10.74 13 70799 27711 46587539
Gastric ulcer 13.79 10.74 8 70804 21855 46593395
Human papilloma virus test positive 13.66 10.74 8 70804 370 46614880
Dementia 13.58 10.74 3 70809 14927 46600323
Haematoma 13.58 10.74 17 70795 31855 46583395
Embolism 13.51 10.74 32 70780 7106 46608144
Mitral valve prolapse 13.48 10.74 17 70795 2272 46612978
Haemangioma of liver 13.47 10.74 12 70800 1075 46614175
Anogenital warts 13.47 10.74 8 70804 380 46614870
Device colour issue 13.46 10.74 4 70808 30 46615220
Social anxiety disorder 13.45 10.74 8 70804 381 46614869
Thyroxine increased 13.39 10.74 9 70803 531 46614719
Ectopic pregnancy with contraceptive device 13.23 10.74 12 70800 1100 46614150
Breast prosthesis user 13.19 10.74 3 70809 6 46615244
Product size issue 13.15 10.74 8 70804 397 46614853
Blister 13.13 10.74 114 70698 44517 46570733
Laparoscopy 13.12 10.74 4 70808 33 46615217
Carotid artery thrombosis 13.12 10.74 10 70802 720 46614530
Rhinitis allergic 13.11 10.74 31 70781 6877 46608373
Pulmonary arterial hypertension 13.09 10.74 12 70800 25916 46589334
Hepatic failure 13.05 10.74 19 70793 33397 46581853
Pemphigus 13.03 10.74 31 70781 45243 46570007
Educational problem 12.97 10.74 7 70805 276 46614974
Papilloedema 12.85 10.74 21 70791 3556 46611694
Device related infection 12.85 10.74 8 70804 21033 46594217
Liver disorder 12.83 10.74 23 70789 37223 46578027
Alanine aminotransferase increased 12.82 10.74 80 70732 88371 46526879
Somnolence 12.78 10.74 164 70648 156357 46458893
Drug clearance increased 12.78 10.74 5 70807 92 46615158
Altered state of consciousness 12.77 10.74 10 70802 23338 46591912
Cholecystitis chronic 12.77 10.74 40 70772 10459 46604791
Cerebral artery occlusion 12.76 10.74 11 70801 943 46614307
Learning disorder 12.72 10.74 8 70804 421 46614829
Colitis ulcerative 12.71 10.74 57 70755 17675 46597575
Upper limb fracture 12.70 10.74 4 70808 15709 46599541
Blood calcium decreased 12.65 10.74 4 70808 15669 46599581
Splenic vein thrombosis 12.63 10.74 7 70805 291 46614959
Skin exfoliation 12.60 10.74 19 70793 32919 46582331
Metastases to liver 12.59 10.74 7 70805 19578 46595672
Contact lens intolerance 12.59 10.74 3 70809 8 46615242
Small for dates baby 12.59 10.74 21 70791 3616 46611634
Seborrhoea 12.57 10.74 8 70804 430 46614820
Blood potassium increased 12.55 10.74 5 70807 16962 46598288
Suppressed lactation 12.51 10.74 8 70804 434 46614816
Depressed mood 12.49 10.74 90 70722 33229 46582021
Oral dysaesthesia 12.39 10.74 5 70807 100 46615150
Cytomegalovirus infection 12.39 10.74 6 70806 18138 46597112
Poisoning 12.36 10.74 3 70809 13991 46601259
Thromboembolectomy 12.35 10.74 4 70808 41 46615209
Lateral medullary syndrome 12.33 10.74 3 70809 9 46615241
Facial operation 12.33 10.74 3 70809 9 46615241
Craniectomy 12.33 10.74 3 70809 9 46615241
Cavernous sinus thrombosis 12.30 10.74 5 70807 102 46615148
Vulvovaginal dryness 12.28 10.74 16 70796 2209 46613041
Thoracic outlet syndrome 12.27 10.74 6 70806 192 46615058
Circulatory collapse 12.16 10.74 9 70803 21615 46593635
Ejection fraction decreased 12.14 10.74 6 70806 17931 46597319
Hepatic function abnormal 12.09 10.74 21 70791 34400 46580850
Cardiac ventricular thrombosis 12.04 10.74 8 70804 463 46614787
Cervix disorder 12.04 10.74 8 70804 463 46614787
Joint stiffness 12.04 10.74 14 70798 27094 46588156
Impaired healing 11.95 10.74 96 70716 36647 46578603
Urinary tract infection 11.95 10.74 249 70563 220017 46395233
Angioplasty 11.90 10.74 12 70800 1255 46613995
Breast cyst 11.87 10.74 13 70799 1496 46613754
Rib fracture 11.86 10.74 7 70805 18947 46596303
Porphyria non-acute 11.83 10.74 7 70805 330 46614920
Blood glucose decreased 11.79 10.74 7 70805 18885 46596365
Unwanted pregnancy 11.78 10.74 4 70808 48 46615202
Orthostatic hypotension 11.76 10.74 12 70800 24646 46590604
Portal fibrosis 11.75 10.74 6 70806 211 46615039
Respiratory distress 11.65 10.74 19 70793 31897 46583353
Off label use 11.60 10.74 695 70117 379146 46236104
Loss of personal independence in daily activities 11.57 10.74 46 70766 57137 46558113
Tubulointerstitial nephritis 11.54 10.74 4 70808 14784 46600466
Band sensation 11.51 10.74 9 70803 673 46614577
Application site irritation 11.50 10.74 14 70798 1805 46613445
Ulcer 11.50 10.74 6 70806 17386 46597864
Blood copper increased 11.48 10.74 3 70809 13 46615237
Drug resistance 11.47 10.74 6 70806 17362 46597888
Progesterone decreased 11.36 10.74 5 70807 125 46615125
Hidradenitis 11.35 10.74 15 70797 2100 46613150
Electrolyte imbalance 11.30 10.74 6 70806 17220 46598030
Tri-iodothyronine free decreased 11.30 10.74 6 70806 229 46615021
Ovarian clear cell carcinoma 11.30 10.74 3 70809 14 46615236
Infectious mononucleosis 11.27 10.74 13 70799 1583 46613667
Adnexa uteri pain 11.19 10.74 7 70805 365 46614885
Myalgia 11.18 10.74 126 70686 122962 46492288
Musculoskeletal stiffness 11.13 10.74 95 70717 97898 46517352
Cervix inflammation 11.13 10.74 3 70809 15 46615235
Splenic thrombosis 11.13 10.74 3 70809 15 46615235
Cervical conisation 11.13 10.74 3 70809 15 46615235
Habitual abortion 11.13 10.74 3 70809 15 46615235
Pulmonary artery thrombosis 11.12 10.74 9 70803 707 46614543
Hiatus hernia 11.12 10.74 7 70805 18295 46596955
Hemiparaesthesia 11.10 10.74 4 70808 58 46615192
Red blood cell sedimentation rate increased 11.08 10.74 11 70801 22878 46592372
Product dispensing error 11.07 10.74 35 70777 9198 46606052
Haemorrhage in pregnancy 11.06 10.74 13 70799 1615 46613635
Pharyngitis streptococcal 10.99 10.74 33 70779 8435 46606815
Biliary dyskinesia 10.95 10.74 17 70795 2756 46612494
Blood lactate dehydrogenase increased 10.94 10.74 9 70803 20491 46594759
Blood pressure decreased 10.93 10.74 47 70765 57112 46558138
Stress 10.93 10.74 123 70689 51428 46563822
Blood triglycerides increased 10.92 10.74 41 70771 11742 46603508
Gonorrhoea 10.91 10.74 5 70807 138 46615112
Application site reaction 10.87 10.74 9 70803 730 46614520
Ovarian cystectomy 10.84 10.74 5 70807 140 46615110
Appendicectomy 10.82 10.74 16 70796 2485 46612765
Injection site pain 10.82 10.74 107 70705 107045 46508205
Perinatal depression 10.82 10.74 8 70804 550 46614700
Product expiration date issue 10.81 10.74 3 70809 17 46615233

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Foetal exposure during pregnancy 121.43 42.24 38 453 36833 29915154
Medical device discomfort 54.37 42.24 7 484 60 29951927
Arnold-Chiari malformation 44.83 42.24 7 484 255 29951732

Pharmacologic Action:

SourceCodeDescription
ATC G03CA01 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
ESTROGENS
Natural and semisynthetic estrogens, plain
ATC L02AA03 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ENDOCRINE THERAPY
HORMONES AND RELATED AGENTS
Estrogens
ATC G03AA01 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA02 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA03 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA04 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA05 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA06 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA07 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA08 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA09 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA10 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA11 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA12 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA13 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA15 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA16 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AB01 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, sequential preparations
ATC G03AB02 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, sequential preparations
ATC G03AB03 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, sequential preparations
ATC G03AB04 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, sequential preparations
ATC G03AB05 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, sequential preparations
ATC G03AB06 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, sequential preparations
ATC G03AB07 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, sequential preparations
ATC G03AB09 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, sequential preparations
FDA MoA N0000000100 Estrogen Receptor Agonists
FDA EPC N0000175825 Estrogen
CHEBI has role CHEBI:76988 xenoestrogens
MeSH PA D003270 Contraceptive Agents
MeSH PA D003271 Contraceptive Agents, Female
MeSH PA D000080066 Contraceptive Agents, Hormonal
MeSH PA D003278 Contraceptives, Oral, Hormonal
MeSH PA D004967 Estrogens
MeSH PA D006728 Hormones
MeSH PA D012102 Reproductive Control Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Premenstrual dysphoric disorder indication 596004
Contraception indication 13197004
Atrophic vaginitis indication 52441000
Acne vulgaris indication 88616000
Postmenopausal osteoporosis indication 102447009
Menopausal flushing indication 198436008
Atrophic vulva indication 248861000 DOID:14275
Amenorrhea off-label use 14302001 DOID:13938
Female hypogonadism syndrome off-label use 16041008
Polycystic ovaries off-label use 69878008
Dysmenorrhea off-label use 266599000
Postcoital contraception off-label use 268463003
Abnormal uterine bleeding unrelated to menstrual cycle off-label use 312984006
Menorrhagia off-label use 386692008
Heart valve disorder contraindication 368009 DOID:4079
Hyperlipoproteinemia contraindication 3744001 DOID:1168
Hypocalcemia contraindication 5291005
Hypercholesterolemia contraindication 13644009
Hyperkalemia contraindication 14140009
Jaundice contraindication 18165001
Myocardial infarction contraindication 22298006 DOID:5844
Diplopia contraindication 24982008
Retinal hemorrhage contraindication 28998008
Depressive disorder contraindication 35489007
Chloasma contraindication 36209000
Migraine contraindication 37796009 DOID:6364
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Body fluid retention contraindication 43498006
Thrombosis of retinal vein contraindication 46085004
Humoral hypercalcemia of malignancy contraindication 47709007
Chronic heart failure contraindication 48447003
Dementia contraindication 52448006
Hepatic porphyria contraindication 55056006 DOID:3133
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Hyperlipidemia contraindication 55822004 DOID:1168
Benign mammary dysplasia contraindication 57993004
Acute nephropathy contraindication 58574008
Obstructive hyperbilirubinemia contraindication 59848001
Thrombophlebitis contraindication 64156001 DOID:3875
Intermenstrual bleeding - irregular contraindication 64996003
Hypercalcemia contraindication 66931009 DOID:12678
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Heart failure contraindication 84114007 DOID:6000
Epilepsy contraindication 84757009 DOID:1826
Breast lump contraindication 89164003
Kidney disease contraindication 90708001 DOID:557
Malignant neoplasm of liver contraindication 93870000 DOID:3571
Uterine leiomyoma contraindication 95315005 DOID:13223
Neoplasm of prostate contraindication 126906006 DOID:10283
Deep venous thrombosis contraindication 128053003
Seizure disorder contraindication 128613002
Endometriosis contraindication 129103003
Bed-ridden contraindication 160685001
Liver function tests abnormal contraindication 166603001
Mammography abnormal contraindication 168750009
Angina pectoris contraindication 194828000
Asthma contraindication 195967001 DOID:2841
Cerebrovascular accident contraindication 230690007
Pulmonary thromboembolism contraindication 233935004
Thrombophilia contraindication 234467004 DOID:2452
Disease of liver contraindication 235856003 DOID:409
Cholestasis of pregnancy contraindication 235888006
Endometrial carcinoma contraindication 254878006 DOID:2871
Benign prostatic hyperplasia contraindication 266569009
Edema contraindication 267038008
Chorea contraindication 271700006
Pregnancy, function contraindication 289908002
Hypertriglyceridemia contraindication 302870006
Functional visual loss contraindication 313165001
Malignant tumor of cervix contraindication 363354003 DOID:4362
Malignant tumor of ovary contraindication 363443007 DOID:2394
Thromboembolic disorder contraindication 371039008
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Cardiovascular event risk contraindication 395112001
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Obesity contraindication 414916001 DOID:9970
Estrogen receptor positive tumor contraindication 416053008
Porphyria contraindication 418470004
Optic disc edema contraindication 423341008 DOID:146
Family history of malignant neoplasm of breast contraindication 429740004
Hypertensive urgency contraindication 443482000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002
Nonspecific Abnormal Papanicolaou Smear of Cervix contraindication
Major Surgery with Prolonged Post-Operative Immobilization contraindication
Diabetes with Vascular Disease Complication contraindication
Benign Hepatic Cell Adenoma contraindication
Breast Carcinoma in Males contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.13 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
0.02MG;1MG MERZEE SLAYBACK PHARMA LLC A212706 Dec. 18, 2020 RX CAPSULE ORAL July 17, 2021 COMPETITIVE GENERIC THERAPY
0.035MG/24HR;0.15MG/24HR ETHINYL ESTRADIOL AND NORELGESTROMIN AMNEAL A213950 Feb. 25, 2021 RX FILM, EXTENDED RELEASE TRANSDERMAL Aug. 25, 2021 COMPETITIVE GENERIC THERAPY
0.03MG/24HR;0.12MG/24HR TWIRLA AGILE N204017 Feb. 14, 2020 RX SYSTEM TRANSDERMAL Feb. 14, 2023 NEW PRODUCT
0.02MG;0.1MG TYBLUME EXELTIS USA INC N209405 March 30, 2020 RX TABLET ORAL March 30, 2023 NEW DOSAGE FORM
0.013MG/24HR;0.15MG/24HR ANNOVERA THERAPEUTICSMD INC N209627 Aug. 10, 2018 RX RING VAGINULLL Aug. 10, 2023 NEW CHEMICAL ENTITY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Estrogen receptor Nuclear hormone receptor AGONIST Kd 9.83 WOMBAT-PK CHEMBL
Mu-type opioid receptor GPCR Ki 4.96 DRUG MATRIX
Adenosine receptor A2a GPCR Ki 4.93 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 7.54 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 6.02 DRUG MATRIX
Glucocorticoid receptor Nuclear hormone receptor Ki 6.11 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 6.35 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 4.73 DRUG MATRIX
Kappa-type opioid receptor GPCR Ki 4.98 DRUG MATRIX
Sex hormone-binding globulin Secreted Kd 6.81 CHEMBL
Multidrug and toxin extrusion protein 2 Transporter IC50 4.69 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 4.68 CHEMBL
Estrogen receptor beta Nuclear hormone receptor IC50 8.09 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 5.66 CHEMBL
Androgen receptor Nuclear hormone receptor IC50 7.30 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 6.24 WOMBAT-PK
5-hydroxytryptamine receptor 4 GPCR Ki 5.88 DRUG MATRIX
Arachidonate 15-lipoxygenase Enzyme IC50 5.25 DRUG MATRIX
Progesterone receptor Transcription factor Ki 6.86 DRUG MATRIX
Androgen receptor Transcription factor IC50 5.09 CHEMBL

External reference:

IDSource
4018022 VUID
N0000146366 NUI
D00554 KEGG_DRUG
4018022 VANDF
C0015011 UMLSCUI
CHEBI:4903 CHEBI
3WF PDB_CHEM_ID
5991 PUBCHEM_CID
CHEMBL691 ChEMBL_ID
DB00977 DRUGBANK_ID
D004997 MESH_DESCRIPTOR_UI
7071 IUPHAR_LIGAND_ID
437 INN_ID
423D2T571U UNII
4124 RXNORM
4698 MMSL
72166 MMSL
d00229 MMSL
001286 NDDF
126097006 SNOMEDCT_US
15432003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NuvaRing HUMAN PRESCRIPTION DRUG LABEL 2 0052-0273 INSERT, EXTENDED RELEASE 0.02 mg VAGINULLL NDA 28 sections
Jinteli HUMAN PRESCRIPTION DRUG LABEL 2 0093-3122 TABLET 5 ug ORAL ANDA 29 sections
Etonogestrel and Ethinyl Estradiol HUMAN PRESCRIPTION DRUG LABEL 2 0093-7679 INSERT, EXTENDED RELEASE 0.02 mg VAGINULLL ANDA 29 sections
XULANE HUMAN PRESCRIPTION DRUG LABEL 2 0378-3340 PATCH 35 ug TRANSDERMAL ANDA 28 sections
NORETHINDRONE ACETATE AND ETHINYL ESTRADIOL HUMAN PRESCRIPTION DRUG LABEL 2 0378-7274 TABLET 0.03 mg ORAL ANDA 15 sections
NORETHINDRONE ACETATE AND ETHINYL ESTRADIOL HUMAN PRESCRIPTION DRUG LABEL 2 0378-7280 TABLET 0.02 mg ORAL ANDA 15 sections
femhrt HUMAN PRESCRIPTION DRUG LABEL 2 0430-0145 TABLET 2.50 ug ORAL NDA 31 sections
Nortrel21 Day HUMAN PRESCRIPTION DRUG LABEL 2 0555-9009 TABLET 0.04 mg ORAL ANDA 21 sections
Junel21 Day HUMAN PRESCRIPTION DRUG LABEL 2 0555-9025 TABLET 20 ug ORAL ANDA 15 sections
Junel21 Day HUMAN PRESCRIPTION DRUG LABEL 2 0555-9027 TABLET 30 ug ORAL ANDA 15 sections
NUVARING HUMAN PRESCRIPTION DRUG LABEL 2 50090-1008 INSERT, EXTENDED RELEASE 0.02 mg VAGINULLL NDA 27 sections
XULANE HUMAN PRESCRIPTION DRUG LABEL 2 50090-1683 PATCH 35 ug TRANSDERMAL ANDA 29 sections
XULANE HUMAN PRESCRIPTION DRUG LABEL 2 50090-1683 PATCH 35 ug TRANSDERMAL ANDA 29 sections
ANNOVERA HUMAN PRESCRIPTION DRUG LABEL 2 50261-313 RING 17.40 mg VAGINULLL NDA 31 sections
Dolishale HUMAN PRESCRIPTION DRUG LABEL 2 50742-659 TABLET 20 ug ORAL ANDA 15 sections
Loestrin21 Day HUMAN PRESCRIPTION DRUG LABEL 2 51285-127 TABLET 30 ug ORAL ANDA 15 sections
Loestrin21 Day HUMAN PRESCRIPTION DRUG LABEL 2 51285-131 TABLET 20 ug ORAL ANDA 15 sections
MICROGESTIN 1/20 HUMAN PRESCRIPTION DRUG LABEL 2 51862-007 TABLET 20 ug ORAL NDA AUTHORIZED GENERIC 21 sections
MICROGESTIN 1.5/30 HUMAN PRESCRIPTION DRUG LABEL 2 51862-279 TABLET 30 ug ORAL NDA AUTHORIZED GENERIC 21 sections
Amethyst HUMAN PRESCRIPTION DRUG LABEL 2 52544-295 TABLET 20 ug ORAL ANDA 24 sections
MICROGESTIN 1/20 HUMAN PRESCRIPTION DRUG LABEL 2 53002-1549 TABLET 20 ug ORAL NDA AUTHORIZED GENERIC 21 sections
femhrt HUMAN PRESCRIPTION DRUG LABEL 2 54868-4679 TABLET 5 ug ORAL NDA 20 sections
NuvaRing HUMAN PRESCRIPTION DRUG LABEL 2 54868-4832 INSERT, EXTENDED RELEASE 2.70 mg VAGINULLL NDA 25 sections
Microgestin HUMAN PRESCRIPTION DRUG LABEL 2 54868-6213 TABLET 0.02 mg ORAL ANDA 24 sections
JINTELI HUMAN PRESCRIPTION DRUG LABEL 2 54868-6251 TABLET 5 ug ORAL ANDA 25 sections
Junel 1.5/30 HUMAN PRESCRIPTION DRUG LABEL 2 54868-6272 TABLET 30 ug ORAL ANDA 23 sections
ZAFEMY HUMAN PRESCRIPTION DRUG LABEL 2 65162-358 PATCH 35 ug TRANSDERMAL ANDA 31 sections
EluRyng HUMAN PRESCRIPTION DRUG LABEL 2 65162-469 RING 0.02 mg VAGINULLL ANDA 29 sections
Aurovela 1.5/30 Human Prescription Drug Label 2 65862-935 TABLET 30 ug ORAL ANDA 14 sections
Aurovela 1/20 Human Prescription Drug Label 2 65862-939 TABLET 20 ug ORAL ANDA 15 sections