All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

etonogestrel 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
steroids, progestogens	1110	54048-10-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: etonogestrel implanon 3-Oxodesogestrel	metabolite of DESOGESTREL; structure given in first source; Implanon: implant containing etonogestrel (3-keto-desogestrel) Molecular weight: 324.46 Formula: C22H28O2 CLOGP: 3.35 LIPINSKI: 0 HAC: 2 HDO: 1 TPSA: 37.30 ALOGS: -4.64 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
68	mcg	s.c. implant

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.51 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.10 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.01 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	76 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	2.87 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	2 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.02 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	25 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Oct. 3, 2001	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
No adverse event	18400.29	52.96	4852	58723	28726	50512823
Complication associated with device	14389.93	52.96	3388	60187	11267	50530282
Device difficult to use	11365.55	52.96	2601	60974	7285	50534264
Device breakage	10845.94	52.96	2488	61087	7059	50534490
Incorrect product administration duration	10272.17	52.96	2368	61207	6907	50534642
Device deployment issue	10259.82	52.96	1997	61578	1499	50540050
Product quality issue	10146.49	52.96	2998	60577	27860	50513689
Complication of device removal	8410.80	52.96	1743	61832	2421	50539128
Complication of device insertion	8396.75	52.96	1858	61717	4183	50537366
Implant site pain	6789.77	52.96	1309	62266	860	50540689
Pregnancy with implant contraceptive	6419.37	52.96	1235	62340	788	50540761
Device kink	5738.17	52.96	1104	62471	703	50540846
Unintended pregnancy	5676.58	52.96	1302	62273	3644	50537905
Device dislocation	4846.81	52.96	1569	62006	19977	50521572
Heavy menstrual bleeding	4394.26	52.96	1348	62227	14189	50527360
Menstruation irregular	4374.30	52.96	1101	62474	5061	50536488
Intermenstrual bleeding	2707.56	52.96	770	62805	6044	50535505
Amenorrhoea	2575.22	52.96	778	62797	7706	50533843
Device expulsion	2557.04	52.96	1058	62517	27764	50513785
Vaginal haemorrhage	2135.75	52.96	889	62686	23662	50517887
Implant site erythema	1834.73	52.96	347	63228	169	50541380
Implant site pruritus	1659.83	52.96	318	63257	188	50541361
Device placement issue	1565.83	52.96	328	63247	488	50541061
Implant site bruising	1336.29	52.96	245	63330	63	50541486
Implant site swelling	1211.94	52.96	241	63334	223	50541326
Implant site infection	1185.88	52.96	266	63309	642	50540907
Implant site scar	1062.24	52.96	196	63379	59	50541490
Implant site fibrosis	979.94	52.96	174	63401	9	50541540
General anaesthesia	977.13	52.96	173	63402	6	50541543
Device issue	930.93	52.96	469	63106	19503	50522046
Menstrual disorder	741.30	52.96	258	63317	4112	50537437
Implant site irritation	730.32	52.96	133	63442	28	50541521
Menometrorrhagia	668.12	52.96	165	63410	684	50540865
Mood swings	663.34	52.96	347	63228	15607	50525942
Menstruation delayed	651.20	52.96	180	63395	1251	50540298
Drug ineffective	610.32	52.96	143	63432	819190	49722359
Adverse event	594.85	52.96	470	63105	43293	50498256
Diarrhoea	574.99	52.96	44	63531	588432	49953117
Medical device site discomfort	565.87	52.96	113	63462	109	50541440
Polymenorrhoea	562.52	52.96	152	63423	959	50540590
Device embolisation	539.75	52.96	95	63480	0	50541549
Weight increased	536.91	52.96	931	62644	200960	50340589
Implant site rash	524.08	52.96	99	63476	47	50541502
Dysmenorrhoea	521.54	52.96	185	63390	3125	50538424
Medical device removal	466.45	52.96	132	63443	1010	50540539
Implant site hypoaesthesia	457.26	52.96	81	63494	3	50541546
Menstruation normal	450.07	52.96	90	63485	88	50541461
Hypomenorrhoea	441.31	52.96	104	63471	336	50541213
Pneumonia	432.40	52.96	9	63566	378392	50163157
Abortion spontaneous	431.61	52.96	383	63192	41389	50500160
Off label use	426.96	52.96	49	63526	474377	50067172
Implant site reaction	425.07	52.96	82	63493	53	50541496
Dyspnoea	405.68	52.96	96	63479	547512	49994037
Implant site haemorrhage	398.18	52.96	74	63501	26	50541523
Fatigue	368.12	52.96	218	63357	707383	49834166
Death	366.69	52.96	9	63566	325370	50216179
Abortion induced	334.35	52.96	184	63391	9160	50532389
Implant site paraesthesia	329.52	52.96	58	63517	0	50541549
Implant site cellulitis	326.59	52.96	58	63517	3	50541546
Implant site discharge	323.82	52.96	65	63510	66	50541483
Oligomenorrhoea	315.90	52.96	87	63488	595	50540954
Surgery	310.04	52.96	276	63299	29929	50511620
Condition aggravated	307.81	52.96	16	63559	297042	50244507
Arthralgia	303.39	52.96	88	63487	438614	50102935
Pyrexia	303.02	52.96	56	63519	380147	50161402
Implant site mass	295.16	52.96	54	63521	13	50541536
Expired product administered	288.13	52.96	139	63436	5243	50536306
Fall	285.44	52.96	41	63534	334891	50206658
Implant site discolouration	267.02	52.96	47	63528	0	50541549
Implant site inflammation	259.27	52.96	55	63520	90	50541459
Acne	256.51	52.96	206	63369	19389	50522160
Hypotension	256.04	52.96	9	63566	235460	50306089
Toxicity to various agents	246.70	52.96	4	63571	212495	50329054
Joint swelling	245.50	52.96	16	63559	245270	50296279
Acute kidney injury	240.25	52.96	11	63564	228047	50313502
Circumstance or information capable of leading to medication error	238.79	52.96	104	63471	3084	50538465
Mood altered	238.08	52.96	166	63409	12607	50528942
Drug hypersensitivity	227.64	52.96	25	63550	250985	50290564
Drug intolerance	223.12	52.96	13	63562	219091	50322458
Rheumatoid arthritis	222.79	52.96	7	63568	202543	50339006
Implant site vesicles	221.57	52.96	39	63536	0	50541549
Cough	221.41	52.96	23	63552	241241	50300308
Wrong technique in device usage process	219.04	52.96	91	63484	2395	50539154
Breast tenderness	213.33	52.96	85	63490	2003	50539546
Vomiting	211.93	52.96	162	63413	460596	50080953
Implant site abscess	204.52	52.96	36	63539	0	50541549
Rash	202.19	52.96	153	63422	437318	50104231
Implant site warmth	198.98	52.96	36	63539	6	50541543
Confusional state	192.47	52.96	10	63565	185918	50355631
Implant site urticaria	189.38	52.96	34	63541	4	50541545
Haemorrhage	187.35	52.96	280	63295	53161	50488388
Nasopharyngitis	186.05	52.96	15	63560	192912	50348637
Anaemia	182.93	52.96	46	63529	252410	50289139
Implant site induration	176.11	52.96	31	63544	0	50541549
Sinusitis	173.95	52.96	10	63565	170548	50371001
Constipation	172.15	52.96	17	63558	185691	50355858
Incorrect route of product administration	167.01	52.96	158	63417	18508	50523041
Neutropenia	166.79	52.96	4	63571	147961	50393588
Asthenia	164.09	52.96	99	63476	318943	50222606
General physical health deterioration	163.92	52.96	3	63572	142431	50399118
Arthropathy	161.82	52.96	9	63566	157897	50383652
Abdominal discomfort	160.63	52.96	46	63529	231595	50309954
Treatment failure	157.98	52.96	3	63572	137634	50403915
Gait disturbance	155.43	52.96	8	63567	149997	50391552
Breast pain	154.68	52.96	104	63471	7440	50534109
Malaise	152.74	52.96	119	63456	335413	50206136
Application site discomfort	151.81	52.96	43	63532	330	50541219
Urinary tract infection	147.21	52.96	49	63526	223971	50317578
Oedema peripheral	144.97	52.96	15	63560	157946	50383603
Systemic lupus erythematosus	144.13	52.96	8	63567	140614	50400935
Hypertension	142.66	52.96	44	63531	211159	50330390
Contraindicated product administered	142.41	52.96	12	63563	148946	50392603
Hepatic enzyme increased	140.23	52.96	8	63567	137372	50404177
Dehydration	136.05	52.96	16	63559	152433	50389116
Therapeutic product effect decreased	135.63	52.96	9	63566	136041	50405508
Musculoskeletal stiffness	132.63	52.96	7	63568	128474	50413075
Haemoglobin decreased	128.05	52.96	8	63567	127208	50414341
Pain in extremity	127.40	52.96	677	62898	272188	50269361
Pregnancy on contraceptive	125.77	52.96	48	63527	1004	50540545
Nausea	120.78	52.96	468	63107	704930	49836619
Somnolence	120.69	52.96	24	63551	154961	50386588
Hormone level abnormal	119.57	52.96	57	63518	2092	50539457
Sepsis	118.47	52.96	14	63561	132911	50408638
Limb discomfort	115.99	52.96	148	63427	24209	50517340
Atrial fibrillation	110.09	52.96	4	63571	101741	50439808
Pain	106.88	52.96	372	63203	578531	49963018
Product prescribing issue	104.03	52.96	44	63531	1212	50540337
Bronchitis	103.48	52.96	7	63568	104152	50437397
Implant site haematoma	102.35	52.96	23	63552	56	50541493
Therapeutic product effect incomplete	101.13	52.96	3	63572	91512	50450037
Vaginal discharge	99.74	52.96	69	63506	5171	50536378
Implant site oedema	99.49	52.96	18	63557	3	50541546
Decreased appetite	96.82	52.96	67	63508	200856	50340693
Breast feeding	95.34	52.96	37	63538	811	50540738
Arthritis	95.26	52.96	3	63572	86718	50454831
Blood pressure increased	94.90	52.96	25	63550	133107	50408442
Hypokalaemia	93.36	52.96	4	63571	87988	50453561
Swelling	92.85	52.96	70	63505	200802	50340747
Needle issue	92.04	52.96	75	63500	7200	50534349
Implant site pustules	90.90	52.96	16	63559	0	50541549
Hypoaesthesia	89.98	52.96	357	63218	126900	50414649
Pruritus	89.67	52.96	136	63439	283432	50258117
Hypersensitivity	89.58	52.96	83	63492	215078	50326471
Device use issue	88.91	52.96	45	63530	1884	50539665
Tremor	84.94	52.96	20	63555	114883	50426666
Injection site pain	84.74	52.96	18	63557	111006	50430543
Myocardial infarction	82.83	52.96	8	63567	89019	50452530
Medical device discomfort	82.82	52.96	41	63534	1636	50539913
Cardiac failure	82.21	52.96	3	63572	76037	50465512
Implant site hypersensitivity	81.96	52.96	16	63559	12	50541537
Tachycardia	80.74	52.96	14	63561	99749	50441800
Infection	80.27	52.96	60	63515	172894	50368655
Alopecia	79.91	52.96	115	63460	244932	50296617
Neuropathy peripheral	79.59	52.96	13	63562	96744	50444805
Chills	79.51	52.96	13	63562	96674	50444875
Insomnia	79.45	52.96	62	63513	174803	50366746
Pleural effusion	79.39	52.96	6	63569	81448	50460101
Abnormal uterine bleeding	79.01	52.96	36	63539	1190	50540359
Ectopic pregnancy	78.24	52.96	44	63531	2283	50539266
Uterine haemorrhage	77.09	52.96	50	63525	3365	50538184
Alanine aminotransferase increased	77.02	52.96	10	63565	88349	50453200
Gastrointestinal disorder	74.83	52.96	14	63561	94442	50447107
Encapsulation reaction	73.85	52.96	13	63562	0	50541549
Dysphagia	72.02	52.96	7	63568	77511	50464038
Memory impairment	71.58	52.96	8	63567	79352	50462197
Gastrooesophageal reflux disease	70.75	52.96	7	63568	76421	50465128
Keloid scar	70.66	52.96	20	63555	153	50541396
Upper respiratory tract infection	69.88	52.96	3	63572	65895	50475654
Herpes zoster	69.59	52.96	5	63570	70781	50470768
Hospitalisation	69.16	52.96	4	63571	67933	50473616
Cerebrovascular accident	68.96	52.96	17	63558	94663	50446886
Bradycardia	68.10	52.96	3	63572	64423	50477126
Aspartate aminotransferase increased	67.56	52.96	9	63566	77989	50463560
Intentional product use issue	66.33	52.96	9	63566	76909	50464640
Scar	66.27	52.96	78	63497	11740	50529809
Wound	66.23	52.96	25	63550	105769	50435780
Influenza	65.36	52.96	16	63559	89522	50452027
Asthma	65.14	52.96	16	63559	89321	50452228
Balance disorder	63.96	52.96	7	63568	70583	50470966
Administration site discomfort	63.18	52.96	16	63559	75	50541474
Drug abuse	62.56	52.96	3	63572	59843	50481706
Implant site nerve injury	62.49	52.96	11	63564	0	50541549
Maternal exposure before pregnancy	61.10	52.96	53	63522	5544	50536005
Ulnar nerve injury	60.18	52.96	14	63561	42	50541507
Blood glucose increased	59.97	52.96	9	63566	71315	50470234
Blood cholesterol increased	56.98	52.96	3	63572	55212	50486337
Wheezing	56.60	52.96	6	63569	62041	50479508
Chest discomfort	56.24	52.96	23	63552	92699	50448850
Coma	55.96	52.96	4	63571	56875	50484674
Psoriasis	55.13	52.96	10	63565	68990	50472559
Flushing	55.11	52.96	9	63566	67006	50474543
Infertility female	54.95	52.96	22	63553	525	50541024
Dyspepsia	54.55	52.96	13	63562	74084	50467465
Unwanted pregnancy	54.37	52.96	12	63563	26	50541523
Pregnancy with contraceptive device	53.60	52.96	43	63532	4036	50537513

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
No adverse event	11809.32	62.16	2917	41101	25644	64429070
Complication associated with device	9592.68	62.16	2186	41832	12894	64441820
Device difficult to use	8825.11	62.16	1890	42128	7908	64446806
Device deployment issue	8058.95	62.16	1432	42586	1394	64453320
Product quality issue	7610.25	62.16	2079	41939	27720	64426994
Device breakage	6803.41	62.16	1497	42521	7258	64447456
Complication of device insertion	6528.80	62.16	1314	42704	3698	64451016
Complication of device removal	6397.71	62.16	1206	42812	2074	64452640
Incorrect product administration duration	6057.27	62.16	1389	42629	8369	64446345
Implant site pain	5613.99	62.16	993	43025	907	64453807
Pregnancy with implant contraceptive	4556.68	62.16	800	43218	664	64454050
Unintended pregnancy	4151.67	62.16	834	43184	2300	64452414
Device kink	3945.93	62.16	724	43294	969	64453745
Device dislocation	3697.68	62.16	1101	42917	20077	64434637
Heavy menstrual bleeding	3640.32	62.16	963	43055	11114	64443600
Menstruation irregular	3124.55	62.16	701	43317	3734	64450980
Device expulsion	2470.38	62.16	809	43209	20327	64434387
Amenorrhoea	2393.53	62.16	609	43409	5930	64448784
Intermenstrual bleeding	2243.79	62.16	551	43467	4574	64450140
Implant site erythema	1615.87	62.16	281	43737	203	64454511
Implant site pruritus	1546.98	62.16	263	43755	134	64454580
Vaginal haemorrhage	1528.99	62.16	553	43465	18791	64435923
Device placement issue	1362.57	62.16	260	43758	486	64454228
Implant site bruising	1124.72	62.16	187	43831	60	64454654
Implant site swelling	1037.20	62.16	189	43829	234	64454480
Implant site fibrosis	867.77	62.16	139	43879	7	64454707
Implant site scar	863.61	62.16	145	43873	58	64454656
General anaesthesia	836.31	62.16	134	43884	7	64454707
Implant site infection	778.63	62.16	189	43829	1480	64453234
Menstrual disorder	638.43	62.16	187	43831	3178	64451536
Implant site irritation	630.62	62.16	103	43915	19	64454695
Medical device removal	609.44	62.16	128	43890	465	64454249
Device issue	600.17	62.16	298	43720	22350	64432364
Menstruation delayed	559.86	62.16	135	43883	1024	64453690
Mood swings	557.13	62.16	261	43757	17207	64437507
Menometrorrhagia	529.24	62.16	116	43902	540	64454174
Abortion spontaneous	486.46	62.16	268	43750	24875	64429839
Dysmenorrhoea	474.72	62.16	139	43879	2358	64452356
Polymenorrhoea	470.59	62.16	112	43906	798	64453916
Weight increased	457.47	62.16	641	43377	212707	64242007
Medical device site discomfort	447.73	62.16	81	43937	93	64454621
Implant site rash	427.81	62.16	75	43943	60	64454654
Hypomenorrhoea	407.36	62.16	84	43934	272	64454442
Menstruation normal	394.22	62.16	64	43954	9	64454705
Diarrhoea	368.03	62.16	35	43983	722669	63732045
Abortion induced	353.74	62.16	141	43877	6247	64448467
Device embolisation	346.25	62.16	58	43960	22	64454692
Pneumonia	340.75	62.16	9	44009	559567	63895147
Implant site hypoaesthesia	340.32	62.16	55	43963	6	64454708
Implant site reaction	327.73	62.16	61	43957	92	64454622
Death	308.99	62.16	4	44014	482701	63972013
Off label use	308.21	62.16	36	43982	632770	63821944
Implant site discharge	295.72	62.16	56	43962	98	64454616
Oligomenorrhoea	292.24	62.16	70	43948	514	64454200
Implant site mass	276.97	62.16	47	43971	23	64454691
Drug ineffective	272.86	62.16	117	43901	840130	63614584
Dyspnoea	269.16	62.16	79	43939	718595	63736119
Implant site cellulitis	265.71	62.16	46	43972	31	64454683
Surgery	262.26	62.16	189	43829	28024	64426690
Acute kidney injury	259.98	62.16	11	44007	449229	64005485
Implant site haemorrhage	259.07	62.16	53	43965	163	64454551
Pyrexia	252.40	62.16	40	43978	558604	63896110
Implant site paraesthesia	245.35	62.16	39	43979	0	64454714
Toxicity to various agents	228.25	62.16	4	44014	363509	64091205
Hypotension	221.45	62.16	9	44009	380965	64073749
Acne	204.01	62.16	150	43868	22931	64431783
Implant site vesicles	202.09	62.16	33	43985	6	64454708
Breast tenderness	197.58	62.16	68	43950	1981	64452733
Fall	197.03	62.16	26	43992	416800	64037914
Condition aggravated	194.57	62.16	16	44002	372410	64082304
Implant site warmth	188.71	62.16	31	43987	7	64454707
Implant site discolouration	183.26	62.16	30	43988	6	64454708
Implant site inflammation	182.68	62.16	40	43978	185	64454529
Mood altered	171.67	62.16	117	43901	15862	64438852
Implant site urticaria	165.27	62.16	27	43991	5	64454709
Implant site induration	157.27	62.16	25	43993	0	64454714
Expired product administered	156.18	62.16	78	43940	5909	64448805
Fatigue	153.02	62.16	172	43846	748558	63706156
Breast pain	152.46	62.16	81	43937	6980	64447734
Anaemia	150.08	62.16	37	43981	378643	64076071
Pain in extremity	150.04	62.16	501	43517	302584	64152130
Implant site abscess	147.64	62.16	26	43992	22	64454692
Haemorrhage	147.10	62.16	223	43795	79128	64375586
Arthralgia	145.56	62.16	60	43958	442200	64012514
Neutropenia	144.98	62.16	4	44014	239620	64215094
Confusional state	142.68	62.16	9	44009	261135	64193579
Wrong technique in device usage process	140.28	62.16	58	43960	2824	64451890
Cough	139.94	62.16	20	43998	302128	64152586
Incorrect route of product administration	138.56	62.16	120	43898	23178	64431536
General physical health deterioration	125.21	62.16	3	44015	204422	64250292
Application site discomfort	124.97	62.16	32	43986	318	64454396
Sepsis	122.71	62.16	9	44009	230332	64224382
Hypoaesthesia	122.54	62.16	284	43734	138824	64315890
Pregnancy on contraceptive	119.97	62.16	37	43981	754	64453960
Adverse event	119.42	62.16	141	43877	39348	64415366
Vomiting	116.37	62.16	123	43895	550994	63903720
Asthenia	114.33	62.16	76	43942	427968	64026746
Dehydration	113.96	62.16	9	44009	216754	64237960
Circumstance or information capable of leading to medication error	112.93	62.16	52	43966	3288	64451426
Drug hypersensitivity	109.47	62.16	16	44002	237799	64216915
Constipation	108.95	62.16	14	44004	229323	64225391
Haemoglobin decreased	108.71	62.16	6	44012	195057	64259657
Joint swelling	107.68	62.16	11	44007	215371	64239343
Oedema peripheral	104.48	62.16	11	44007	210306	64244408
Vaginal discharge	104.04	62.16	52	43966	3945	64450769
Drug intolerance	101.11	62.16	7	44011	187985	64266729
Atrial fibrillation	99.41	62.16	4	44014	171085	64283629
Nasopharyngitis	98.05	62.16	10	44008	196063	64258651
Rheumatoid arthritis	94.92	62.16	4	44014	164290	64290424
Implant site pustules	91.63	62.16	15	44003	3	64454711
Gait disturbance	90.89	62.16	7	44011	172148	64282566
Rash	90.52	62.16	108	43910	458441	63996273
Limb discomfort	90.51	62.16	102	43916	27073	64427641
Myocardial infarction	89.68	62.16	6	44012	165815	64288899
Ectopic pregnancy	88.24	62.16	35	43983	1529	64453185
Hypertension	87.09	62.16	34	43984	259227	64195487
Breast feeding	86.59	62.16	28	43990	669	64454045
Implant site oedema	86.12	62.16	15	44003	11	64454703
Somnolence	84.36	62.16	18	44000	203627	64251087
Hormone level abnormal	81.69	62.16	34	43984	1683	64453031
Sinusitis	79.73	62.16	5	44013	145923	64308791
Malaise	79.59	62.16	92	43926	396155	64058559
Medical device discomfort	78.19	62.16	32	43986	1517	64453197
Cardiac failure	77.21	62.16	3	44015	132370	64322344
Decreased appetite	73.60	62.16	51	43967	281238	64173476
Implant site hypersensitivity	71.81	62.16	13	44005	15	64454699
Hypokalaemia	70.30	62.16	3	44015	121900	64332814
Arthropathy	69.68	62.16	3	44015	120964	64333750
Encapsulation reaction	69.20	62.16	11	44007	0	64454714
Discomfort	68.83	62.16	163	43855	80715	64373999
Bradycardia	67.87	62.16	3	44015	118216	64336498
Pregnancy with contraceptive device	67.36	62.16	36	43982	3138	64451576
Pleural effusion	67.20	62.16	5	44013	126554	64328160
Alanine aminotransferase increased	67.18	62.16	8	44010	139023	64315691
Treatment failure	66.95	62.16	3	44015	116813	64337901
Tachycardia	66.67	62.16	11	44007	149568	64305146
Implant site haematoma	63.71	62.16	16	44002	146	64454568
Implant site nerve injury	62.91	62.16	10	44008	0	64454714

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	G03AC08	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens
FDA CS	M0447349	Progesterone Congeners
FDA EPC	N0000175602	Progestin
MeSH PA	D003270	Contraceptive Agents
MeSH PA	D003271	Contraceptive Agents, Female
MeSH PA	D000080066	Contraceptive Agents, Hormonal
MeSH PA	D012102	Reproductive Control Agents
CHEBI has role	CHEBI:49323	contraceptive drugs
CHEBI has role	CHEBI:49324	female contraceptive drugs
CHEBI has role	CHEBI:59826	progestins

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Contraception	indication	13197004
Heart valve disorder	contraindication	368009	DOID:4079
Hypercholesterolemia	contraindication	13644009
Toxic shock syndrome	contraindication	18504008	DOID:14115
Myocardial infarction	contraindication	22298006	DOID:5844
Diplopia	contraindication	24982008
Retinal hemorrhage	contraindication	28998008
Depressive disorder	contraindication	35489007
Migraine	contraindication	37796009	DOID:6364
Hypertensive disorder	contraindication	38341003	DOID:10763
Disorder of gallbladder	contraindication	39621005	DOID:0060262
Body fluid retention	contraindication	43498006
Thrombosis of retinal vein	contraindication	46085004
Chronic heart failure	contraindication	48447003
Dementia	contraindication	52448006
Systemic lupus erythematosus	contraindication	55464009	DOID:9074
Hyperlipidemia	contraindication	55822004	DOID:1168
Cerebrovascular disease	contraindication	62914000	DOID:6713
Thrombophlebitis	contraindication	64156001	DOID:3875
Intermenstrual bleeding - irregular	contraindication	64996003
Diabetes mellitus	contraindication	73211009	DOID:9351
Kidney disease	contraindication	90708001	DOID:557
Malignant neoplasm of liver	contraindication	93870000	DOID:3571
Deep venous thrombosis	contraindication	128053003
Seizure disorder	contraindication	128613002
Bed-ridden	contraindication	160685001
Asthma	contraindication	195967001	DOID:2841
Cerebrovascular accident	contraindication	230690007
Pulmonary thromboembolism	contraindication	233935004
Disease of liver	contraindication	235856003	DOID:409
Cholestasis of pregnancy	contraindication	235888006
Metabolic syndrome X	contraindication	237602007	DOID:14221
Endometrial carcinoma	contraindication	254878006	DOID:2871
Pregnancy, function	contraindication	289908002
Hypertriglyceridemia	contraindication	302870006
Functional visual loss	contraindication	313165001
Non-Q wave myocardial infarction	contraindication	314207007
Malignant tumor of ovary	contraindication	363443007	DOID:2394
Thromboembolic disorder	contraindication	371039008
Disorder of coronary artery	contraindication	414024009
Obesity	contraindication	414916001	DOID:9970
Estrogen receptor positive tumor	contraindication	416053008
Porphyria	contraindication	418470004
Optic disc edema	contraindication	423341008	DOID:146
Hypertensive urgency	contraindication	443482000
Carcinoma of female breast	contraindication	447782002
Smokes tobacco daily	contraindication	449868002
Worsening Headache Disorder	contraindication
Major Surgery with Prolonged Post-Operative Immobilization	contraindication
Diabetes with Vascular Disease Complication	contraindication
Benign Hepatic Cell Adenoma	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.93	acidic

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
68MG/IMPLANT	IMPLANON	ORGANON	N021529	July 17, 2006	DISCN	IMPLANT	IMPLANTATION	9757552	July 28, 2030	PREVENTION OF PREGNANCY
68MG/IMPLANT	NEXPLANON	ORGANON	N021529	May 31, 2011	RX	IMPLANT	IMPLANTATION	9757552	July 28, 2030	PREVENTION OF PREGNANCY

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Progesterone receptor	Nuclear hormone receptor	P06401	PRGR_HUMAN	AGONIST				WOMBAT-PK	CHEMBL
Estrogen receptor	Nuclear hormone receptor	P03372	ESR1_HUMAN					WOMBAT-PK
Sex hormone-binding globulin	Secreted	P04278	SHBG_HUMAN		Kd	8.23		CHEMBL

External reference:

ID	Source
4021294	VUID
N0000179018	NUI
D04104	KEGG_DRUG
4021294	VANDF
C0047683	UMLSCUI
CHEBI:50777	CHEBI
CHEMBL1531	ChEMBL_ID
CHEMBL1697750	ChEMBL_ID
DB00294	DRUGBANK_ID
C044815	MESH_SUPPLEMENTAL_RECORD_UI
6917715	PUBCHEM_CID
7590	IUPHAR_LIGAND_ID
6832	INN_ID
304GTH6RNH	UNII
14584	RXNORM
16189	MMSL
51895	MMSL
d04772	MMSL
007906	NDDF
326451000	SNOMEDCT_US
396050000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
NuvaRing	HUMAN PRESCRIPTION DRUG LABEL	2	0052-0273	INSERT, EXTENDED RELEASE	0.12 mg	VAGINAL	NDA	28 sections
Nexplanon	HUMAN PRESCRIPTION DRUG LABEL	1	0052-4330	IMPLANT	68 mg	SUBCUTANEOUS	NDA	29 sections
Etonogestrel and Ethinyl Estradiol	HUMAN PRESCRIPTION DRUG LABEL	2	0093-7679	INSERT, EXTENDED RELEASE	0.12 mg	VAGINAL	ANDA	29 sections
NUVARING	HUMAN PRESCRIPTION DRUG LABEL	2	50090-1008	INSERT, EXTENDED RELEASE	0.12 mg	VAGINAL	NDA	27 sections
NUVARING	HUMAN PRESCRIPTION DRUG LABEL	2	50090-5611	INSERT, EXTENDED RELEASE	0.12 mg	VAGINAL	NDA	27 sections
Etonogestrel/Ethinyl Estradiol	HUMAN PRESCRIPTION DRUG LABEL	2	50090-5959	INSERT, EXTENDED RELEASE	0.12 mg	VAGINAL	NDA AUTHORIZED GENERIC	29 sections
NuvaRing	HUMAN PRESCRIPTION DRUG LABEL	2	54868-4832	INSERT, EXTENDED RELEASE	11.70 mg	VAGINAL	NDA	25 sections
EluRyng	HUMAN PRESCRIPTION DRUG LABEL	2	65162-469	RING	0.12 mg	VAGINAL	ANDA	29 sections
EluRyng	HUMAN PRESCRIPTION DRUG LABEL	2	65162-469	RING	0.12 mg	VAGINAL	ANDA	29 sections
Etonogestrel/Ethinyl Estradiol	HUMAN PRESCRIPTION DRUG LABEL	2	66993-605	INSERT, EXTENDED RELEASE	0.12 mg	VAGINAL	NDA AUTHORIZED GENERIC	30 sections
Etonogestrel/Ethinyl Estradiol	HUMAN PRESCRIPTION DRUG LABEL	2	66993-605	INSERT, EXTENDED RELEASE	0.12 mg	VAGINAL	NDA AUTHORIZED GENERIC	30 sections
NuvaRing	HUMAN PRESCRIPTION DRUG LABEL	2	76413-131	INSERT, EXTENDED RELEASE	0.12 mg	VAGINAL	NDA	28 sections
Nexplanon	HUMAN PRESCRIPTION DRUG LABEL	1	78206-145	IMPLANT	68 mg	SUBCUTANEOUS	NDA	29 sections
NuvaRing	HUMAN PRESCRIPTION DRUG LABEL	2	78206-146	INSERT, EXTENDED RELEASE	0.12 mg	VAGINAL	NDA	29 sections
NuvaRing	HUMAN PRESCRIPTION DRUG LABEL	2	78206-146	INSERT, EXTENDED RELEASE	0.12 mg	VAGINAL	NDA	29 sections