Stem definition | Drug id | CAS RN |
---|---|---|
steroids, progestogens | 1110 | 54048-10-1 |
Dose | Unit | Route |
---|---|---|
68 | mcg | s.c. implant |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.51 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.10 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.01 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 76 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.87 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.02 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 25 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 3, 2001 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
No adverse event | 18400.29 | 52.96 | 4852 | 58723 | 28726 | 50512823 |
Complication associated with device | 14389.93 | 52.96 | 3388 | 60187 | 11267 | 50530282 |
Device difficult to use | 11365.55 | 52.96 | 2601 | 60974 | 7285 | 50534264 |
Device breakage | 10845.94 | 52.96 | 2488 | 61087 | 7059 | 50534490 |
Incorrect product administration duration | 10272.17 | 52.96 | 2368 | 61207 | 6907 | 50534642 |
Device deployment issue | 10259.82 | 52.96 | 1997 | 61578 | 1499 | 50540050 |
Product quality issue | 10146.49 | 52.96 | 2998 | 60577 | 27860 | 50513689 |
Complication of device removal | 8410.80 | 52.96 | 1743 | 61832 | 2421 | 50539128 |
Complication of device insertion | 8396.75 | 52.96 | 1858 | 61717 | 4183 | 50537366 |
Implant site pain | 6789.77 | 52.96 | 1309 | 62266 | 860 | 50540689 |
Pregnancy with implant contraceptive | 6419.37 | 52.96 | 1235 | 62340 | 788 | 50540761 |
Device kink | 5738.17 | 52.96 | 1104 | 62471 | 703 | 50540846 |
Unintended pregnancy | 5676.58 | 52.96 | 1302 | 62273 | 3644 | 50537905 |
Device dislocation | 4846.81 | 52.96 | 1569 | 62006 | 19977 | 50521572 |
Heavy menstrual bleeding | 4394.26 | 52.96 | 1348 | 62227 | 14189 | 50527360 |
Menstruation irregular | 4374.30 | 52.96 | 1101 | 62474 | 5061 | 50536488 |
Intermenstrual bleeding | 2707.56 | 52.96 | 770 | 62805 | 6044 | 50535505 |
Amenorrhoea | 2575.22 | 52.96 | 778 | 62797 | 7706 | 50533843 |
Device expulsion | 2557.04 | 52.96 | 1058 | 62517 | 27764 | 50513785 |
Vaginal haemorrhage | 2135.75 | 52.96 | 889 | 62686 | 23662 | 50517887 |
Implant site erythema | 1834.73 | 52.96 | 347 | 63228 | 169 | 50541380 |
Implant site pruritus | 1659.83 | 52.96 | 318 | 63257 | 188 | 50541361 |
Device placement issue | 1565.83 | 52.96 | 328 | 63247 | 488 | 50541061 |
Implant site bruising | 1336.29 | 52.96 | 245 | 63330 | 63 | 50541486 |
Implant site swelling | 1211.94 | 52.96 | 241 | 63334 | 223 | 50541326 |
Implant site infection | 1185.88 | 52.96 | 266 | 63309 | 642 | 50540907 |
Implant site scar | 1062.24 | 52.96 | 196 | 63379 | 59 | 50541490 |
Implant site fibrosis | 979.94 | 52.96 | 174 | 63401 | 9 | 50541540 |
General anaesthesia | 977.13 | 52.96 | 173 | 63402 | 6 | 50541543 |
Device issue | 930.93 | 52.96 | 469 | 63106 | 19503 | 50522046 |
Menstrual disorder | 741.30 | 52.96 | 258 | 63317 | 4112 | 50537437 |
Implant site irritation | 730.32 | 52.96 | 133 | 63442 | 28 | 50541521 |
Menometrorrhagia | 668.12 | 52.96 | 165 | 63410 | 684 | 50540865 |
Mood swings | 663.34 | 52.96 | 347 | 63228 | 15607 | 50525942 |
Menstruation delayed | 651.20 | 52.96 | 180 | 63395 | 1251 | 50540298 |
Drug ineffective | 610.32 | 52.96 | 143 | 63432 | 819190 | 49722359 |
Adverse event | 594.85 | 52.96 | 470 | 63105 | 43293 | 50498256 |
Diarrhoea | 574.99 | 52.96 | 44 | 63531 | 588432 | 49953117 |
Medical device site discomfort | 565.87 | 52.96 | 113 | 63462 | 109 | 50541440 |
Polymenorrhoea | 562.52 | 52.96 | 152 | 63423 | 959 | 50540590 |
Device embolisation | 539.75 | 52.96 | 95 | 63480 | 0 | 50541549 |
Weight increased | 536.91 | 52.96 | 931 | 62644 | 200960 | 50340589 |
Implant site rash | 524.08 | 52.96 | 99 | 63476 | 47 | 50541502 |
Dysmenorrhoea | 521.54 | 52.96 | 185 | 63390 | 3125 | 50538424 |
Medical device removal | 466.45 | 52.96 | 132 | 63443 | 1010 | 50540539 |
Implant site hypoaesthesia | 457.26 | 52.96 | 81 | 63494 | 3 | 50541546 |
Menstruation normal | 450.07 | 52.96 | 90 | 63485 | 88 | 50541461 |
Hypomenorrhoea | 441.31 | 52.96 | 104 | 63471 | 336 | 50541213 |
Pneumonia | 432.40 | 52.96 | 9 | 63566 | 378392 | 50163157 |
Abortion spontaneous | 431.61 | 52.96 | 383 | 63192 | 41389 | 50500160 |
Off label use | 426.96 | 52.96 | 49 | 63526 | 474377 | 50067172 |
Implant site reaction | 425.07 | 52.96 | 82 | 63493 | 53 | 50541496 |
Dyspnoea | 405.68 | 52.96 | 96 | 63479 | 547512 | 49994037 |
Implant site haemorrhage | 398.18 | 52.96 | 74 | 63501 | 26 | 50541523 |
Fatigue | 368.12 | 52.96 | 218 | 63357 | 707383 | 49834166 |
Death | 366.69 | 52.96 | 9 | 63566 | 325370 | 50216179 |
Abortion induced | 334.35 | 52.96 | 184 | 63391 | 9160 | 50532389 |
Implant site paraesthesia | 329.52 | 52.96 | 58 | 63517 | 0 | 50541549 |
Implant site cellulitis | 326.59 | 52.96 | 58 | 63517 | 3 | 50541546 |
Implant site discharge | 323.82 | 52.96 | 65 | 63510 | 66 | 50541483 |
Oligomenorrhoea | 315.90 | 52.96 | 87 | 63488 | 595 | 50540954 |
Surgery | 310.04 | 52.96 | 276 | 63299 | 29929 | 50511620 |
Condition aggravated | 307.81 | 52.96 | 16 | 63559 | 297042 | 50244507 |
Arthralgia | 303.39 | 52.96 | 88 | 63487 | 438614 | 50102935 |
Pyrexia | 303.02 | 52.96 | 56 | 63519 | 380147 | 50161402 |
Implant site mass | 295.16 | 52.96 | 54 | 63521 | 13 | 50541536 |
Expired product administered | 288.13 | 52.96 | 139 | 63436 | 5243 | 50536306 |
Fall | 285.44 | 52.96 | 41 | 63534 | 334891 | 50206658 |
Implant site discolouration | 267.02 | 52.96 | 47 | 63528 | 0 | 50541549 |
Implant site inflammation | 259.27 | 52.96 | 55 | 63520 | 90 | 50541459 |
Acne | 256.51 | 52.96 | 206 | 63369 | 19389 | 50522160 |
Hypotension | 256.04 | 52.96 | 9 | 63566 | 235460 | 50306089 |
Toxicity to various agents | 246.70 | 52.96 | 4 | 63571 | 212495 | 50329054 |
Joint swelling | 245.50 | 52.96 | 16 | 63559 | 245270 | 50296279 |
Acute kidney injury | 240.25 | 52.96 | 11 | 63564 | 228047 | 50313502 |
Circumstance or information capable of leading to medication error | 238.79 | 52.96 | 104 | 63471 | 3084 | 50538465 |
Mood altered | 238.08 | 52.96 | 166 | 63409 | 12607 | 50528942 |
Drug hypersensitivity | 227.64 | 52.96 | 25 | 63550 | 250985 | 50290564 |
Drug intolerance | 223.12 | 52.96 | 13 | 63562 | 219091 | 50322458 |
Rheumatoid arthritis | 222.79 | 52.96 | 7 | 63568 | 202543 | 50339006 |
Implant site vesicles | 221.57 | 52.96 | 39 | 63536 | 0 | 50541549 |
Cough | 221.41 | 52.96 | 23 | 63552 | 241241 | 50300308 |
Wrong technique in device usage process | 219.04 | 52.96 | 91 | 63484 | 2395 | 50539154 |
Breast tenderness | 213.33 | 52.96 | 85 | 63490 | 2003 | 50539546 |
Vomiting | 211.93 | 52.96 | 162 | 63413 | 460596 | 50080953 |
Implant site abscess | 204.52 | 52.96 | 36 | 63539 | 0 | 50541549 |
Rash | 202.19 | 52.96 | 153 | 63422 | 437318 | 50104231 |
Implant site warmth | 198.98 | 52.96 | 36 | 63539 | 6 | 50541543 |
Confusional state | 192.47 | 52.96 | 10 | 63565 | 185918 | 50355631 |
Implant site urticaria | 189.38 | 52.96 | 34 | 63541 | 4 | 50541545 |
Haemorrhage | 187.35 | 52.96 | 280 | 63295 | 53161 | 50488388 |
Nasopharyngitis | 186.05 | 52.96 | 15 | 63560 | 192912 | 50348637 |
Anaemia | 182.93 | 52.96 | 46 | 63529 | 252410 | 50289139 |
Implant site induration | 176.11 | 52.96 | 31 | 63544 | 0 | 50541549 |
Sinusitis | 173.95 | 52.96 | 10 | 63565 | 170548 | 50371001 |
Constipation | 172.15 | 52.96 | 17 | 63558 | 185691 | 50355858 |
Incorrect route of product administration | 167.01 | 52.96 | 158 | 63417 | 18508 | 50523041 |
Neutropenia | 166.79 | 52.96 | 4 | 63571 | 147961 | 50393588 |
Asthenia | 164.09 | 52.96 | 99 | 63476 | 318943 | 50222606 |
General physical health deterioration | 163.92 | 52.96 | 3 | 63572 | 142431 | 50399118 |
Arthropathy | 161.82 | 52.96 | 9 | 63566 | 157897 | 50383652 |
Abdominal discomfort | 160.63 | 52.96 | 46 | 63529 | 231595 | 50309954 |
Treatment failure | 157.98 | 52.96 | 3 | 63572 | 137634 | 50403915 |
Gait disturbance | 155.43 | 52.96 | 8 | 63567 | 149997 | 50391552 |
Breast pain | 154.68 | 52.96 | 104 | 63471 | 7440 | 50534109 |
Malaise | 152.74 | 52.96 | 119 | 63456 | 335413 | 50206136 |
Application site discomfort | 151.81 | 52.96 | 43 | 63532 | 330 | 50541219 |
Urinary tract infection | 147.21 | 52.96 | 49 | 63526 | 223971 | 50317578 |
Oedema peripheral | 144.97 | 52.96 | 15 | 63560 | 157946 | 50383603 |
Systemic lupus erythematosus | 144.13 | 52.96 | 8 | 63567 | 140614 | 50400935 |
Hypertension | 142.66 | 52.96 | 44 | 63531 | 211159 | 50330390 |
Contraindicated product administered | 142.41 | 52.96 | 12 | 63563 | 148946 | 50392603 |
Hepatic enzyme increased | 140.23 | 52.96 | 8 | 63567 | 137372 | 50404177 |
Dehydration | 136.05 | 52.96 | 16 | 63559 | 152433 | 50389116 |
Therapeutic product effect decreased | 135.63 | 52.96 | 9 | 63566 | 136041 | 50405508 |
Musculoskeletal stiffness | 132.63 | 52.96 | 7 | 63568 | 128474 | 50413075 |
Haemoglobin decreased | 128.05 | 52.96 | 8 | 63567 | 127208 | 50414341 |
Pain in extremity | 127.40 | 52.96 | 677 | 62898 | 272188 | 50269361 |
Pregnancy on contraceptive | 125.77 | 52.96 | 48 | 63527 | 1004 | 50540545 |
Nausea | 120.78 | 52.96 | 468 | 63107 | 704930 | 49836619 |
Somnolence | 120.69 | 52.96 | 24 | 63551 | 154961 | 50386588 |
Hormone level abnormal | 119.57 | 52.96 | 57 | 63518 | 2092 | 50539457 |
Sepsis | 118.47 | 52.96 | 14 | 63561 | 132911 | 50408638 |
Limb discomfort | 115.99 | 52.96 | 148 | 63427 | 24209 | 50517340 |
Atrial fibrillation | 110.09 | 52.96 | 4 | 63571 | 101741 | 50439808 |
Pain | 106.88 | 52.96 | 372 | 63203 | 578531 | 49963018 |
Product prescribing issue | 104.03 | 52.96 | 44 | 63531 | 1212 | 50540337 |
Bronchitis | 103.48 | 52.96 | 7 | 63568 | 104152 | 50437397 |
Implant site haematoma | 102.35 | 52.96 | 23 | 63552 | 56 | 50541493 |
Therapeutic product effect incomplete | 101.13 | 52.96 | 3 | 63572 | 91512 | 50450037 |
Vaginal discharge | 99.74 | 52.96 | 69 | 63506 | 5171 | 50536378 |
Implant site oedema | 99.49 | 52.96 | 18 | 63557 | 3 | 50541546 |
Decreased appetite | 96.82 | 52.96 | 67 | 63508 | 200856 | 50340693 |
Breast feeding | 95.34 | 52.96 | 37 | 63538 | 811 | 50540738 |
Arthritis | 95.26 | 52.96 | 3 | 63572 | 86718 | 50454831 |
Blood pressure increased | 94.90 | 52.96 | 25 | 63550 | 133107 | 50408442 |
Hypokalaemia | 93.36 | 52.96 | 4 | 63571 | 87988 | 50453561 |
Swelling | 92.85 | 52.96 | 70 | 63505 | 200802 | 50340747 |
Needle issue | 92.04 | 52.96 | 75 | 63500 | 7200 | 50534349 |
Implant site pustules | 90.90 | 52.96 | 16 | 63559 | 0 | 50541549 |
Hypoaesthesia | 89.98 | 52.96 | 357 | 63218 | 126900 | 50414649 |
Pruritus | 89.67 | 52.96 | 136 | 63439 | 283432 | 50258117 |
Hypersensitivity | 89.58 | 52.96 | 83 | 63492 | 215078 | 50326471 |
Device use issue | 88.91 | 52.96 | 45 | 63530 | 1884 | 50539665 |
Tremor | 84.94 | 52.96 | 20 | 63555 | 114883 | 50426666 |
Injection site pain | 84.74 | 52.96 | 18 | 63557 | 111006 | 50430543 |
Myocardial infarction | 82.83 | 52.96 | 8 | 63567 | 89019 | 50452530 |
Medical device discomfort | 82.82 | 52.96 | 41 | 63534 | 1636 | 50539913 |
Cardiac failure | 82.21 | 52.96 | 3 | 63572 | 76037 | 50465512 |
Implant site hypersensitivity | 81.96 | 52.96 | 16 | 63559 | 12 | 50541537 |
Tachycardia | 80.74 | 52.96 | 14 | 63561 | 99749 | 50441800 |
Infection | 80.27 | 52.96 | 60 | 63515 | 172894 | 50368655 |
Alopecia | 79.91 | 52.96 | 115 | 63460 | 244932 | 50296617 |
Neuropathy peripheral | 79.59 | 52.96 | 13 | 63562 | 96744 | 50444805 |
Chills | 79.51 | 52.96 | 13 | 63562 | 96674 | 50444875 |
Insomnia | 79.45 | 52.96 | 62 | 63513 | 174803 | 50366746 |
Pleural effusion | 79.39 | 52.96 | 6 | 63569 | 81448 | 50460101 |
Abnormal uterine bleeding | 79.01 | 52.96 | 36 | 63539 | 1190 | 50540359 |
Ectopic pregnancy | 78.24 | 52.96 | 44 | 63531 | 2283 | 50539266 |
Uterine haemorrhage | 77.09 | 52.96 | 50 | 63525 | 3365 | 50538184 |
Alanine aminotransferase increased | 77.02 | 52.96 | 10 | 63565 | 88349 | 50453200 |
Gastrointestinal disorder | 74.83 | 52.96 | 14 | 63561 | 94442 | 50447107 |
Encapsulation reaction | 73.85 | 52.96 | 13 | 63562 | 0 | 50541549 |
Dysphagia | 72.02 | 52.96 | 7 | 63568 | 77511 | 50464038 |
Memory impairment | 71.58 | 52.96 | 8 | 63567 | 79352 | 50462197 |
Gastrooesophageal reflux disease | 70.75 | 52.96 | 7 | 63568 | 76421 | 50465128 |
Keloid scar | 70.66 | 52.96 | 20 | 63555 | 153 | 50541396 |
Upper respiratory tract infection | 69.88 | 52.96 | 3 | 63572 | 65895 | 50475654 |
Herpes zoster | 69.59 | 52.96 | 5 | 63570 | 70781 | 50470768 |
Hospitalisation | 69.16 | 52.96 | 4 | 63571 | 67933 | 50473616 |
Cerebrovascular accident | 68.96 | 52.96 | 17 | 63558 | 94663 | 50446886 |
Bradycardia | 68.10 | 52.96 | 3 | 63572 | 64423 | 50477126 |
Aspartate aminotransferase increased | 67.56 | 52.96 | 9 | 63566 | 77989 | 50463560 |
Intentional product use issue | 66.33 | 52.96 | 9 | 63566 | 76909 | 50464640 |
Scar | 66.27 | 52.96 | 78 | 63497 | 11740 | 50529809 |
Wound | 66.23 | 52.96 | 25 | 63550 | 105769 | 50435780 |
Influenza | 65.36 | 52.96 | 16 | 63559 | 89522 | 50452027 |
Asthma | 65.14 | 52.96 | 16 | 63559 | 89321 | 50452228 |
Balance disorder | 63.96 | 52.96 | 7 | 63568 | 70583 | 50470966 |
Administration site discomfort | 63.18 | 52.96 | 16 | 63559 | 75 | 50541474 |
Drug abuse | 62.56 | 52.96 | 3 | 63572 | 59843 | 50481706 |
Implant site nerve injury | 62.49 | 52.96 | 11 | 63564 | 0 | 50541549 |
Maternal exposure before pregnancy | 61.10 | 52.96 | 53 | 63522 | 5544 | 50536005 |
Ulnar nerve injury | 60.18 | 52.96 | 14 | 63561 | 42 | 50541507 |
Blood glucose increased | 59.97 | 52.96 | 9 | 63566 | 71315 | 50470234 |
Blood cholesterol increased | 56.98 | 52.96 | 3 | 63572 | 55212 | 50486337 |
Wheezing | 56.60 | 52.96 | 6 | 63569 | 62041 | 50479508 |
Chest discomfort | 56.24 | 52.96 | 23 | 63552 | 92699 | 50448850 |
Coma | 55.96 | 52.96 | 4 | 63571 | 56875 | 50484674 |
Psoriasis | 55.13 | 52.96 | 10 | 63565 | 68990 | 50472559 |
Flushing | 55.11 | 52.96 | 9 | 63566 | 67006 | 50474543 |
Infertility female | 54.95 | 52.96 | 22 | 63553 | 525 | 50541024 |
Dyspepsia | 54.55 | 52.96 | 13 | 63562 | 74084 | 50467465 |
Unwanted pregnancy | 54.37 | 52.96 | 12 | 63563 | 26 | 50541523 |
Pregnancy with contraceptive device | 53.60 | 52.96 | 43 | 63532 | 4036 | 50537513 |
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
No adverse event | 11809.32 | 62.16 | 2917 | 41101 | 25644 | 64429070 |
Complication associated with device | 9592.68 | 62.16 | 2186 | 41832 | 12894 | 64441820 |
Device difficult to use | 8825.11 | 62.16 | 1890 | 42128 | 7908 | 64446806 |
Device deployment issue | 8058.95 | 62.16 | 1432 | 42586 | 1394 | 64453320 |
Product quality issue | 7610.25 | 62.16 | 2079 | 41939 | 27720 | 64426994 |
Device breakage | 6803.41 | 62.16 | 1497 | 42521 | 7258 | 64447456 |
Complication of device insertion | 6528.80 | 62.16 | 1314 | 42704 | 3698 | 64451016 |
Complication of device removal | 6397.71 | 62.16 | 1206 | 42812 | 2074 | 64452640 |
Incorrect product administration duration | 6057.27 | 62.16 | 1389 | 42629 | 8369 | 64446345 |
Implant site pain | 5613.99 | 62.16 | 993 | 43025 | 907 | 64453807 |
Pregnancy with implant contraceptive | 4556.68 | 62.16 | 800 | 43218 | 664 | 64454050 |
Unintended pregnancy | 4151.67 | 62.16 | 834 | 43184 | 2300 | 64452414 |
Device kink | 3945.93 | 62.16 | 724 | 43294 | 969 | 64453745 |
Device dislocation | 3697.68 | 62.16 | 1101 | 42917 | 20077 | 64434637 |
Heavy menstrual bleeding | 3640.32 | 62.16 | 963 | 43055 | 11114 | 64443600 |
Menstruation irregular | 3124.55 | 62.16 | 701 | 43317 | 3734 | 64450980 |
Device expulsion | 2470.38 | 62.16 | 809 | 43209 | 20327 | 64434387 |
Amenorrhoea | 2393.53 | 62.16 | 609 | 43409 | 5930 | 64448784 |
Intermenstrual bleeding | 2243.79 | 62.16 | 551 | 43467 | 4574 | 64450140 |
Implant site erythema | 1615.87 | 62.16 | 281 | 43737 | 203 | 64454511 |
Implant site pruritus | 1546.98 | 62.16 | 263 | 43755 | 134 | 64454580 |
Vaginal haemorrhage | 1528.99 | 62.16 | 553 | 43465 | 18791 | 64435923 |
Device placement issue | 1362.57 | 62.16 | 260 | 43758 | 486 | 64454228 |
Implant site bruising | 1124.72 | 62.16 | 187 | 43831 | 60 | 64454654 |
Implant site swelling | 1037.20 | 62.16 | 189 | 43829 | 234 | 64454480 |
Implant site fibrosis | 867.77 | 62.16 | 139 | 43879 | 7 | 64454707 |
Implant site scar | 863.61 | 62.16 | 145 | 43873 | 58 | 64454656 |
General anaesthesia | 836.31 | 62.16 | 134 | 43884 | 7 | 64454707 |
Implant site infection | 778.63 | 62.16 | 189 | 43829 | 1480 | 64453234 |
Menstrual disorder | 638.43 | 62.16 | 187 | 43831 | 3178 | 64451536 |
Implant site irritation | 630.62 | 62.16 | 103 | 43915 | 19 | 64454695 |
Medical device removal | 609.44 | 62.16 | 128 | 43890 | 465 | 64454249 |
Device issue | 600.17 | 62.16 | 298 | 43720 | 22350 | 64432364 |
Menstruation delayed | 559.86 | 62.16 | 135 | 43883 | 1024 | 64453690 |
Mood swings | 557.13 | 62.16 | 261 | 43757 | 17207 | 64437507 |
Menometrorrhagia | 529.24 | 62.16 | 116 | 43902 | 540 | 64454174 |
Abortion spontaneous | 486.46 | 62.16 | 268 | 43750 | 24875 | 64429839 |
Dysmenorrhoea | 474.72 | 62.16 | 139 | 43879 | 2358 | 64452356 |
Polymenorrhoea | 470.59 | 62.16 | 112 | 43906 | 798 | 64453916 |
Weight increased | 457.47 | 62.16 | 641 | 43377 | 212707 | 64242007 |
Medical device site discomfort | 447.73 | 62.16 | 81 | 43937 | 93 | 64454621 |
Implant site rash | 427.81 | 62.16 | 75 | 43943 | 60 | 64454654 |
Hypomenorrhoea | 407.36 | 62.16 | 84 | 43934 | 272 | 64454442 |
Menstruation normal | 394.22 | 62.16 | 64 | 43954 | 9 | 64454705 |
Diarrhoea | 368.03 | 62.16 | 35 | 43983 | 722669 | 63732045 |
Abortion induced | 353.74 | 62.16 | 141 | 43877 | 6247 | 64448467 |
Device embolisation | 346.25 | 62.16 | 58 | 43960 | 22 | 64454692 |
Pneumonia | 340.75 | 62.16 | 9 | 44009 | 559567 | 63895147 |
Implant site hypoaesthesia | 340.32 | 62.16 | 55 | 43963 | 6 | 64454708 |
Implant site reaction | 327.73 | 62.16 | 61 | 43957 | 92 | 64454622 |
Death | 308.99 | 62.16 | 4 | 44014 | 482701 | 63972013 |
Off label use | 308.21 | 62.16 | 36 | 43982 | 632770 | 63821944 |
Implant site discharge | 295.72 | 62.16 | 56 | 43962 | 98 | 64454616 |
Oligomenorrhoea | 292.24 | 62.16 | 70 | 43948 | 514 | 64454200 |
Implant site mass | 276.97 | 62.16 | 47 | 43971 | 23 | 64454691 |
Drug ineffective | 272.86 | 62.16 | 117 | 43901 | 840130 | 63614584 |
Dyspnoea | 269.16 | 62.16 | 79 | 43939 | 718595 | 63736119 |
Implant site cellulitis | 265.71 | 62.16 | 46 | 43972 | 31 | 64454683 |
Surgery | 262.26 | 62.16 | 189 | 43829 | 28024 | 64426690 |
Acute kidney injury | 259.98 | 62.16 | 11 | 44007 | 449229 | 64005485 |
Implant site haemorrhage | 259.07 | 62.16 | 53 | 43965 | 163 | 64454551 |
Pyrexia | 252.40 | 62.16 | 40 | 43978 | 558604 | 63896110 |
Implant site paraesthesia | 245.35 | 62.16 | 39 | 43979 | 0 | 64454714 |
Toxicity to various agents | 228.25 | 62.16 | 4 | 44014 | 363509 | 64091205 |
Hypotension | 221.45 | 62.16 | 9 | 44009 | 380965 | 64073749 |
Acne | 204.01 | 62.16 | 150 | 43868 | 22931 | 64431783 |
Implant site vesicles | 202.09 | 62.16 | 33 | 43985 | 6 | 64454708 |
Breast tenderness | 197.58 | 62.16 | 68 | 43950 | 1981 | 64452733 |
Fall | 197.03 | 62.16 | 26 | 43992 | 416800 | 64037914 |
Condition aggravated | 194.57 | 62.16 | 16 | 44002 | 372410 | 64082304 |
Implant site warmth | 188.71 | 62.16 | 31 | 43987 | 7 | 64454707 |
Implant site discolouration | 183.26 | 62.16 | 30 | 43988 | 6 | 64454708 |
Implant site inflammation | 182.68 | 62.16 | 40 | 43978 | 185 | 64454529 |
Mood altered | 171.67 | 62.16 | 117 | 43901 | 15862 | 64438852 |
Implant site urticaria | 165.27 | 62.16 | 27 | 43991 | 5 | 64454709 |
Implant site induration | 157.27 | 62.16 | 25 | 43993 | 0 | 64454714 |
Expired product administered | 156.18 | 62.16 | 78 | 43940 | 5909 | 64448805 |
Fatigue | 153.02 | 62.16 | 172 | 43846 | 748558 | 63706156 |
Breast pain | 152.46 | 62.16 | 81 | 43937 | 6980 | 64447734 |
Anaemia | 150.08 | 62.16 | 37 | 43981 | 378643 | 64076071 |
Pain in extremity | 150.04 | 62.16 | 501 | 43517 | 302584 | 64152130 |
Implant site abscess | 147.64 | 62.16 | 26 | 43992 | 22 | 64454692 |
Haemorrhage | 147.10 | 62.16 | 223 | 43795 | 79128 | 64375586 |
Arthralgia | 145.56 | 62.16 | 60 | 43958 | 442200 | 64012514 |
Neutropenia | 144.98 | 62.16 | 4 | 44014 | 239620 | 64215094 |
Confusional state | 142.68 | 62.16 | 9 | 44009 | 261135 | 64193579 |
Wrong technique in device usage process | 140.28 | 62.16 | 58 | 43960 | 2824 | 64451890 |
Cough | 139.94 | 62.16 | 20 | 43998 | 302128 | 64152586 |
Incorrect route of product administration | 138.56 | 62.16 | 120 | 43898 | 23178 | 64431536 |
General physical health deterioration | 125.21 | 62.16 | 3 | 44015 | 204422 | 64250292 |
Application site discomfort | 124.97 | 62.16 | 32 | 43986 | 318 | 64454396 |
Sepsis | 122.71 | 62.16 | 9 | 44009 | 230332 | 64224382 |
Hypoaesthesia | 122.54 | 62.16 | 284 | 43734 | 138824 | 64315890 |
Pregnancy on contraceptive | 119.97 | 62.16 | 37 | 43981 | 754 | 64453960 |
Adverse event | 119.42 | 62.16 | 141 | 43877 | 39348 | 64415366 |
Vomiting | 116.37 | 62.16 | 123 | 43895 | 550994 | 63903720 |
Asthenia | 114.33 | 62.16 | 76 | 43942 | 427968 | 64026746 |
Dehydration | 113.96 | 62.16 | 9 | 44009 | 216754 | 64237960 |
Circumstance or information capable of leading to medication error | 112.93 | 62.16 | 52 | 43966 | 3288 | 64451426 |
Drug hypersensitivity | 109.47 | 62.16 | 16 | 44002 | 237799 | 64216915 |
Constipation | 108.95 | 62.16 | 14 | 44004 | 229323 | 64225391 |
Haemoglobin decreased | 108.71 | 62.16 | 6 | 44012 | 195057 | 64259657 |
Joint swelling | 107.68 | 62.16 | 11 | 44007 | 215371 | 64239343 |
Oedema peripheral | 104.48 | 62.16 | 11 | 44007 | 210306 | 64244408 |
Vaginal discharge | 104.04 | 62.16 | 52 | 43966 | 3945 | 64450769 |
Drug intolerance | 101.11 | 62.16 | 7 | 44011 | 187985 | 64266729 |
Atrial fibrillation | 99.41 | 62.16 | 4 | 44014 | 171085 | 64283629 |
Nasopharyngitis | 98.05 | 62.16 | 10 | 44008 | 196063 | 64258651 |
Rheumatoid arthritis | 94.92 | 62.16 | 4 | 44014 | 164290 | 64290424 |
Implant site pustules | 91.63 | 62.16 | 15 | 44003 | 3 | 64454711 |
Gait disturbance | 90.89 | 62.16 | 7 | 44011 | 172148 | 64282566 |
Rash | 90.52 | 62.16 | 108 | 43910 | 458441 | 63996273 |
Limb discomfort | 90.51 | 62.16 | 102 | 43916 | 27073 | 64427641 |
Myocardial infarction | 89.68 | 62.16 | 6 | 44012 | 165815 | 64288899 |
Ectopic pregnancy | 88.24 | 62.16 | 35 | 43983 | 1529 | 64453185 |
Hypertension | 87.09 | 62.16 | 34 | 43984 | 259227 | 64195487 |
Breast feeding | 86.59 | 62.16 | 28 | 43990 | 669 | 64454045 |
Implant site oedema | 86.12 | 62.16 | 15 | 44003 | 11 | 64454703 |
Somnolence | 84.36 | 62.16 | 18 | 44000 | 203627 | 64251087 |
Hormone level abnormal | 81.69 | 62.16 | 34 | 43984 | 1683 | 64453031 |
Sinusitis | 79.73 | 62.16 | 5 | 44013 | 145923 | 64308791 |
Malaise | 79.59 | 62.16 | 92 | 43926 | 396155 | 64058559 |
Medical device discomfort | 78.19 | 62.16 | 32 | 43986 | 1517 | 64453197 |
Cardiac failure | 77.21 | 62.16 | 3 | 44015 | 132370 | 64322344 |
Decreased appetite | 73.60 | 62.16 | 51 | 43967 | 281238 | 64173476 |
Implant site hypersensitivity | 71.81 | 62.16 | 13 | 44005 | 15 | 64454699 |
Hypokalaemia | 70.30 | 62.16 | 3 | 44015 | 121900 | 64332814 |
Arthropathy | 69.68 | 62.16 | 3 | 44015 | 120964 | 64333750 |
Encapsulation reaction | 69.20 | 62.16 | 11 | 44007 | 0 | 64454714 |
Discomfort | 68.83 | 62.16 | 163 | 43855 | 80715 | 64373999 |
Bradycardia | 67.87 | 62.16 | 3 | 44015 | 118216 | 64336498 |
Pregnancy with contraceptive device | 67.36 | 62.16 | 36 | 43982 | 3138 | 64451576 |
Pleural effusion | 67.20 | 62.16 | 5 | 44013 | 126554 | 64328160 |
Alanine aminotransferase increased | 67.18 | 62.16 | 8 | 44010 | 139023 | 64315691 |
Treatment failure | 66.95 | 62.16 | 3 | 44015 | 116813 | 64337901 |
Tachycardia | 66.67 | 62.16 | 11 | 44007 | 149568 | 64305146 |
Implant site haematoma | 63.71 | 62.16 | 16 | 44002 | 146 | 64454568 |
Implant site nerve injury | 62.91 | 62.16 | 10 | 44008 | 0 | 64454714 |
None
Source | Code | Description |
---|---|---|
ATC | G03AC08 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens |
FDA CS | M0447349 | Progesterone Congeners |
FDA EPC | N0000175602 | Progestin |
MeSH PA | D003270 | Contraceptive Agents |
MeSH PA | D003271 | Contraceptive Agents, Female |
MeSH PA | D000080066 | Contraceptive Agents, Hormonal |
MeSH PA | D012102 | Reproductive Control Agents |
CHEBI has role | CHEBI:49323 | contraceptive drugs |
CHEBI has role | CHEBI:49324 | female contraceptive drugs |
CHEBI has role | CHEBI:59826 | progestins |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Contraception | indication | 13197004 | |
Heart valve disorder | contraindication | 368009 | DOID:4079 |
Hypercholesterolemia | contraindication | 13644009 | |
Toxic shock syndrome | contraindication | 18504008 | DOID:14115 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Diplopia | contraindication | 24982008 | |
Retinal hemorrhage | contraindication | 28998008 | |
Depressive disorder | contraindication | 35489007 | |
Migraine | contraindication | 37796009 | DOID:6364 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Body fluid retention | contraindication | 43498006 | |
Thrombosis of retinal vein | contraindication | 46085004 | |
Chronic heart failure | contraindication | 48447003 | |
Dementia | contraindication | 52448006 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Hyperlipidemia | contraindication | 55822004 | DOID:1168 |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Thrombophlebitis | contraindication | 64156001 | DOID:3875 |
Intermenstrual bleeding - irregular | contraindication | 64996003 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Malignant neoplasm of liver | contraindication | 93870000 | DOID:3571 |
Deep venous thrombosis | contraindication | 128053003 | |
Seizure disorder | contraindication | 128613002 | |
Bed-ridden | contraindication | 160685001 | |
Asthma | contraindication | 195967001 | DOID:2841 |
Cerebrovascular accident | contraindication | 230690007 | |
Pulmonary thromboembolism | contraindication | 233935004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Cholestasis of pregnancy | contraindication | 235888006 | |
Metabolic syndrome X | contraindication | 237602007 | DOID:14221 |
Endometrial carcinoma | contraindication | 254878006 | DOID:2871 |
Pregnancy, function | contraindication | 289908002 | |
Hypertriglyceridemia | contraindication | 302870006 | |
Functional visual loss | contraindication | 313165001 | |
Non-Q wave myocardial infarction | contraindication | 314207007 | |
Malignant tumor of ovary | contraindication | 363443007 | DOID:2394 |
Thromboembolic disorder | contraindication | 371039008 | |
Disorder of coronary artery | contraindication | 414024009 | |
Obesity | contraindication | 414916001 | DOID:9970 |
Estrogen receptor positive tumor | contraindication | 416053008 | |
Porphyria | contraindication | 418470004 | |
Optic disc edema | contraindication | 423341008 | DOID:146 |
Hypertensive urgency | contraindication | 443482000 | |
Carcinoma of female breast | contraindication | 447782002 | |
Smokes tobacco daily | contraindication | 449868002 | |
Worsening Headache Disorder | contraindication | ||
Major Surgery with Prolonged Post-Operative Immobilization | contraindication | ||
Diabetes with Vascular Disease Complication | contraindication | ||
Benign Hepatic Cell Adenoma | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 13.93 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
68MG/IMPLANT | IMPLANON | ORGANON | N021529 | July 17, 2006 | DISCN | IMPLANT | IMPLANTATION | 9757552 | July 28, 2030 | PREVENTION OF PREGNANCY |
68MG/IMPLANT | NEXPLANON | ORGANON | N021529 | May 31, 2011 | RX | IMPLANT | IMPLANTATION | 9757552 | July 28, 2030 | PREVENTION OF PREGNANCY |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Progesterone receptor | Nuclear hormone receptor | AGONIST | WOMBAT-PK | CHEMBL | |||||
Estrogen receptor | Nuclear hormone receptor | WOMBAT-PK | |||||||
Sex hormone-binding globulin | Secreted | Kd | 8.23 | CHEMBL |
ID | Source |
---|---|
4021294 | VUID |
N0000179018 | NUI |
D04104 | KEGG_DRUG |
4021294 | VANDF |
C0047683 | UMLSCUI |
CHEBI:50777 | CHEBI |
CHEMBL1531 | ChEMBL_ID |
CHEMBL1697750 | ChEMBL_ID |
DB00294 | DRUGBANK_ID |
C044815 | MESH_SUPPLEMENTAL_RECORD_UI |
6917715 | PUBCHEM_CID |
7590 | IUPHAR_LIGAND_ID |
6832 | INN_ID |
304GTH6RNH | UNII |
14584 | RXNORM |
16189 | MMSL |
51895 | MMSL |
d04772 | MMSL |
007906 | NDDF |
326451000 | SNOMEDCT_US |
396050000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
NuvaRing | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0052-0273 | INSERT, EXTENDED RELEASE | 0.12 mg | VAGINAL | NDA | 28 sections |
Nexplanon | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-4330 | IMPLANT | 68 mg | SUBCUTANEOUS | NDA | 29 sections |
Etonogestrel and Ethinyl Estradiol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0093-7679 | INSERT, EXTENDED RELEASE | 0.12 mg | VAGINAL | ANDA | 29 sections |
NUVARING | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-1008 | INSERT, EXTENDED RELEASE | 0.12 mg | VAGINAL | NDA | 27 sections |
NUVARING | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-5611 | INSERT, EXTENDED RELEASE | 0.12 mg | VAGINAL | NDA | 27 sections |
Etonogestrel/Ethinyl Estradiol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-5959 | INSERT, EXTENDED RELEASE | 0.12 mg | VAGINAL | NDA AUTHORIZED GENERIC | 29 sections |
NuvaRing | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-4832 | INSERT, EXTENDED RELEASE | 11.70 mg | VAGINAL | NDA | 25 sections |
EluRyng | HUMAN PRESCRIPTION DRUG LABEL | 2 | 65162-469 | RING | 0.12 mg | VAGINAL | ANDA | 29 sections |
EluRyng | HUMAN PRESCRIPTION DRUG LABEL | 2 | 65162-469 | RING | 0.12 mg | VAGINAL | ANDA | 29 sections |
Etonogestrel/Ethinyl Estradiol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 66993-605 | INSERT, EXTENDED RELEASE | 0.12 mg | VAGINAL | NDA AUTHORIZED GENERIC | 30 sections |
Etonogestrel/Ethinyl Estradiol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 66993-605 | INSERT, EXTENDED RELEASE | 0.12 mg | VAGINAL | NDA AUTHORIZED GENERIC | 30 sections |
NuvaRing | HUMAN PRESCRIPTION DRUG LABEL | 2 | 76413-131 | INSERT, EXTENDED RELEASE | 0.12 mg | VAGINAL | NDA | 28 sections |
Nexplanon | HUMAN PRESCRIPTION DRUG LABEL | 1 | 78206-145 | IMPLANT | 68 mg | SUBCUTANEOUS | NDA | 29 sections |
NuvaRing | HUMAN PRESCRIPTION DRUG LABEL | 2 | 78206-146 | INSERT, EXTENDED RELEASE | 0.12 mg | VAGINAL | NDA | 29 sections |
NuvaRing | HUMAN PRESCRIPTION DRUG LABEL | 2 | 78206-146 | INSERT, EXTENDED RELEASE | 0.12 mg | VAGINAL | NDA | 29 sections |