etonogestrel 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
steroids, progestogens 1110 54048-10-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • etonogestrel
  • implanon
  • 3-Oxodesogestrel
metabolite of DESOGESTREL; structure given in first source; Implanon: implant containing etonogestrel (3-keto-desogestrel)
  • Molecular weight: 324.46
  • Formula: C22H28O2
  • CLOGP: 3.35
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -4.64
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
68 mcg s.c. implant

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.51 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.01 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 76 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.87 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 25 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.325 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.402 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 66.988 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 31.623 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 4.270 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 5.710 % High 1
herg hERG pIC50 4.750 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 7.551 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 79.983 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 3.280 % High 1
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,JAK3,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK,TGFBR1 20
kinase-selectivity-class GRK2 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.728 High 1
mh-clint Mouse hepatocyte intrinsic clearance 104.472 High 1
mppb Mouse plasma protein binding (% unbound) 4.660 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.958 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 9.050 % High 1
rh-clint Rat hepatocyte intrinsic clearance 100.925 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 29.850 % High 1
rppb Rat plasma protein binding (% unbound) 5.410 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 35.975 uM High 1

Approvals:

DateAgencyCompanyOrphan
Oct. 3, 2001 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
No adverse event 20361.56 31.13 5783 81891 62199 90478574
Complication associated with device 20161.08 31.13 4478 83196 14971 90525802
Pregnancy with implant contraceptive 13634.84 31.13 2464 85210 1297 90539476
Unintended pregnancy 13335.67 31.13 2709 84965 4928 90535845
Incorrect product administration duration 12776.61 31.13 3092 84582 16230 90524543
Device breakage 12419.25 31.13 2845 84829 11199 90529574
Complication of device removal 11920.10 31.13 2387 85287 3868 90536905
Device deployment issue 11016.82 31.13 2148 85526 2761 90538012
Device difficult to use 10712.98 31.13 2634 85040 14891 90525882
Complication of device insertion 9661.05 31.13 2196 85478 8240 90532533
Product quality issue 9638.06 31.13 3402 84272 75923 90464850
Implant site pain 8242.22 31.13 1523 86151 1089 90539684
Device dislocation 6994.57 31.13 2135 85539 29347 90511426
Device kink 6550.01 31.13 1223 86451 992 90539781
Heavy menstrual bleeding 4971.43 31.13 1489 86185 19041 90521732
Menstruation irregular 4920.17 31.13 1212 86462 6848 90533925
Device expulsion 4794.04 31.13 1712 85962 39174 90501599
Intermenstrual bleeding 3644.05 31.13 981 86693 8242 90532531
Amenorrhoea 3021.86 31.13 893 86781 10829 90529944
Device placement issue 2975.20 31.13 624 87050 1406 90539367
Vaginal haemorrhage 2947.49 31.13 1116 86558 30155 90510618
Device issue 2482.70 31.13 970 86704 28567 90512206
Implant site erythema 2263.17 31.13 416 87258 273 90540500
Implant site pruritus 1889.16 31.13 355 87319 307 90540466
Implant site scar 1750.66 31.13 305 87369 69 90540704
Implant site infection 1618.85 31.13 344 87330 845 90539928
Implant site bruising 1586.02 31.13 286 87388 140 90540633
Implant site swelling 1489.38 31.13 284 87390 288 90540485
Implant site fibrosis 1351.88 31.13 231 87443 22 90540751
General anaesthesia 1331.80 31.13 231 87443 45 90540728
Device embolisation 980.56 31.13 165 87509 0 90540773
Abortion spontaneous 935.21 31.13 607 87067 53449 90487324
Implant site irritation 901.45 31.13 157 87517 35 90540738
Uterine haemorrhage 892.13 31.13 284 87390 4468 90536305
Menstrual disorder 887.09 31.13 301 87373 5837 90534936
Abortion induced 854.18 31.13 349 87325 11539 90529234
Medical device site discomfort 842.87 31.13 161 87513 166 90540607
Menstruation delayed 794.37 31.13 217 87457 1928 90538845
Menometrorrhagia 791.76 31.13 194 87480 1061 90539712
Mood swings 756.19 31.13 379 87295 20323 90520450
Dysmenorrhoea 659.02 31.13 225 87449 4447 90536326
Off label use 630.91 31.13 148 87526 1102104 89438669
Polymenorrhoea 617.39 31.13 163 87511 1254 90539519
Implant site rash 598.96 31.13 110 87564 71 90540702
Diarrhoea 598.35 31.13 97 87577 939093 89601680
Implant site haemorrhage 586.23 31.13 102 87572 22 90540751
Drug ineffective 581.68 31.13 310 87364 1383988 89156785
Medical device removal 541.16 31.13 145 87529 1188 90539585
Implant site hypoaesthesia 525.92 31.13 89 87585 3 90540770
Hypomenorrhoea 515.40 31.13 121 87553 533 90540240
Menstruation normal 503.46 31.13 97 87577 109 90540664
Implant site reaction 499.04 31.13 91 87583 53 90540720
Implant site cellulitis 469.61 31.13 80 87594 6 90540767
Pneumonia 456.30 31.13 45 87629 638014 89902759
Condition aggravated 447.60 31.13 34 87640 595511 89945262
Fatigue 431.34 31.13 296 87378 1153727 89387046
Implant site discharge 414.26 31.13 79 87595 80 90540693
Dyspnoea 412.48 31.13 169 87505 880786 89659987
Surgery 409.82 31.13 343 87331 44544 90496229
Implant site paraesthesia 404.07 31.13 68 87606 0 90540773
Joint swelling 394.92 31.13 23 87651 503277 90037496
Weight increased 394.04 31.13 1086 86588 416841 90123932
Implant site inflammation 392.80 31.13 80 87594 145 90540628
Infusion related reaction 386.41 31.13 3 87671 416777 90123996
Adverse event 370.41 31.13 510 87164 116908 90423865
Pyrexia 370.37 31.13 92 87582 660393 89880380
Arthralgia 366.44 31.13 148 87526 778374 89762399
Implant site mass 362.55 31.13 63 87611 13 90540760
Death 354.69 31.13 22 87652 456529 90084244
Drug intolerance 346.41 31.13 22 87652 447569 90093204
Wrong technique in device usage process 337.94 31.13 147 87527 5688 90535085
Implant site discolouration 326.82 31.13 55 87619 0 90540773
Oligomenorrhoea 325.98 31.13 93 87581 982 90539791
Pregnancy with contraceptive device 324.29 31.13 137 87537 4929 90535844
Expired product administered 323.18 31.13 150 87524 6772 90534001
Implant site abscess 305.14 31.13 52 87622 4 90540769
Rheumatoid arthritis 302.37 31.13 11 87663 362603 90178170
Arthropathy 299.00 31.13 13 87661 366229 90174544
General physical health deterioration 295.32 31.13 11 87663 355104 90185669
Hepatic enzyme increased 290.60 31.13 14 87660 360722 90180051
Acne 289.91 31.13 232 87442 28275 90512498
Drug hypersensitivity 285.35 31.13 52 87622 463557 90077216
Fall 284.04 31.13 60 87614 481750 90059023
Systemic lupus erythematosus 282.31 31.13 17 87657 361879 90178894
Abdominal discomfort 280.25 31.13 60 87614 477268 90063505
Nasopharyngitis 277.29 31.13 34 87640 407070 90133703
Confusional state 276.36 31.13 27 87647 386178 90154595
Mood altered 275.53 31.13 184 87490 16960 90523813
Implant site vesicles 271.05 31.13 47 87627 9 90540764
Circumstance or information capable of leading to medication error 271.02 31.13 120 87554 4847 90535926
Rash 267.53 31.13 227 87447 795873 89744900
Pulmonary embolism 264.74 31.13 463 87211 130357 90410416
Breast tenderness 263.06 31.13 98 87576 2514 90538259
Implant site warmth 260.90 31.13 45 87629 7 90540766
Toxicity to various agents 257.92 31.13 4 87670 287842 90252931
Vomiting 256.13 31.13 232 87442 788061 89752712
Medical device discomfort 255.55 31.13 91 87583 2045 90538728
Acute kidney injury 253.08 31.13 14 87660 320373 90220400
Stomatitis 249.69 31.13 3 87671 274695 90266078
Musculoskeletal stiffness 247.15 31.13 9 87665 296523 90244250
Treatment failure 244.09 31.13 12 87662 303916 90236857
Sinusitis 235.20 31.13 28 87646 343060 90197713
Ectopic pregnancy with contraceptive device 232.75 31.13 77 87597 1375 90539398
Implant site injury 231.74 31.13 39 87635 0 90540773
Hypertension 231.72 31.13 77 87597 457455 90083318
Pregnancy on contraceptive 229.11 31.13 74 87600 1221 90539552
Haemorrhage 228.77 31.13 308 87366 69061 90471712
Implant site induration 225.80 31.13 38 87636 0 90540773
Hypotension 224.43 31.13 26 87648 325371 90215402
Cough 223.50 31.13 43 87631 368919 90171854
Lower respiratory tract infection 222.39 31.13 4 87670 250655 90290118
Implant site urticaria 219.38 31.13 38 87636 7 90540766
Contraindicated product administered 217.29 31.13 27 87647 320112 90220661
Therapeutic product effect decreased 216.53 31.13 13 87661 277558 90263215
Malaise 211.86 31.13 155 87519 585831 89954942
Asthenia 199.74 31.13 136 87538 533615 90007158
Psoriatic arthropathy 197.22 31.13 5 87669 228330 90312443
Wheezing 192.42 31.13 9 87665 238071 90302702
Neutropenia 190.28 31.13 6 87668 224898 90315875
Gait disturbance 189.48 31.13 17 87657 260479 90280294
Inappropriate schedule of product administration 183.90 31.13 431 87243 149502 90391271
Swelling 179.01 31.13 91 87583 418967 90121806
Thrombocytopenia 178.65 31.13 5 87669 208720 90332053
Hypersensitivity 178.02 31.13 110 87564 454567 90086206
Wound 177.84 31.13 38 87636 302942 90237831
Breast pain 177.55 31.13 116 87558 10302 90530471
Abnormal uterine bleeding 175.61 31.13 68 87606 1944 90538829
Osteoarthritis 174.11 31.13 3 87671 195727 90345046
Gastrointestinal disorder 173.29 31.13 22 87652 256665 90284108
Alopecia 172.40 31.13 136 87538 494935 90045838
Implant site oedema 169.47 31.13 29 87645 3 90540770
Implant site necrosis 169.47 31.13 29 87645 3 90540770
Blood cholesterol increased 167.64 31.13 8 87666 208004 90332769
Intentional product use issue 166.62 31.13 11 87663 216881 90323892
Ectopic pregnancy 166.27 31.13 75 87599 3166 90537607
Device use issue 165.71 31.13 78 87596 3635 90537138
Decreased appetite 163.46 31.13 80 87594 376460 90164313
Constipation 162.87 31.13 36 87638 280359 90260414
Deep vein thrombosis 162.06 31.13 306 87368 91314 90449459
Abortion 160.50 31.13 70 87604 2725 90538048
Type 2 diabetes mellitus 160.06 31.13 9 87665 203235 90337538
Fibromyalgia 159.82 31.13 10 87664 206259 90334514
Blister 158.03 31.13 28 87646 254970 90285803
Application site discomfort 156.09 31.13 43 87631 395 90540378
Dry mouth 155.37 31.13 5 87669 184054 90356719
Irritable bowel syndrome 155.09 31.13 12 87662 207436 90333337
C-reactive protein increased 152.85 31.13 5 87669 181384 90359389
Therapeutic product effect incomplete 151.43 31.13 9 87665 193887 90346886
Liver injury 150.13 31.13 3 87671 170564 90370209
Anaemia 150.05 31.13 77 87597 352725 90188048
Pruritus 148.01 31.13 184 87490 541341 89999432
Implant site haematoma 146.72 31.13 30 87644 56 90540717
Wrong technique in product usage process 144.28 31.13 253 87421 71318 90469455
White blood cell count decreased 143.01 31.13 4 87670 167105 90373668
Infection 142.51 31.13 87 87587 362007 90178766
Oedema peripheral 140.25 31.13 38 87636 257877 90282896
Hormone level abnormal 139.55 31.13 64 87610 2809 90537964
Mobility decreased 138.13 31.13 36 87638 250698 90290075
Ill-defined disorder 137.35 31.13 11 87663 184880 90355893
Implant site pustules 136.67 31.13 23 87651 0 90540773
Arthritis 136.23 31.13 6 87668 167309 90373464
Memory impairment 135.33 31.13 16 87658 197228 90343545
Pain 134.95 31.13 503 87171 995838 89544935
Oedema 130.82 31.13 19 87655 200276 90340497
Vaginal discharge 128.62 31.13 124 87550 19340 90521433
Completed suicide 125.90 31.13 3 87671 145055 90395718
Pain in extremity 124.93 31.13 804 86870 449725 90091048
Asthma 123.78 31.13 40 87634 242120 90298653
Dyspepsia 120.09 31.13 23 87651 198137 90342636
Gait inability 120.07 31.13 5 87669 146451 90394322
Lung disorder 120.00 31.13 6 87668 149877 90390896
Limb discomfort 119.40 31.13 165 87509 37895 90502878
Encapsulation reaction 118.84 31.13 20 87654 0 90540773
Sleep disorder 117.88 31.13 24 87650 198006 90342767
Joint range of motion decreased 116.98 31.13 3 87671 135640 90405133
Dehydration 114.85 31.13 24 87650 194423 90346350
Implant site hypersensitivity 113.48 31.13 21 87653 15 90540758
Therapy non-responder 110.96 31.13 5 87669 136699 90404074
Insomnia 109.33 31.13 97 87577 333377 90207396
Peripheral swelling 109.03 31.13 144 87530 412962 90127811
Platelet count decreased 108.03 31.13 6 87668 136963 90403810
Hyponatraemia 108.01 31.13 5 87669 133533 90407240
Nausea 106.46 31.13 635 87039 1109681 89431092
Atrial fibrillation 104.92 31.13 6 87668 133605 90407168
Somnolence 104.29 31.13 36 87638 209048 90331725
Breast feeding 103.30 31.13 37 87637 846 90539927
Scar 99.69 31.13 97 87577 15298 90525475
Keloid scar 97.62 31.13 27 87647 252 90540521
Maternal exposure before pregnancy 96.78 31.13 83 87591 11130 90529643
Loss of personal independence in daily activities 95.98 31.13 10 87664 136095 90404678
Inflammation 95.78 31.13 27 87647 178565 90362208
Vulvovaginal discomfort 94.41 31.13 48 87626 2649 90538124
Liver disorder 93.55 31.13 6 87668 121263 90419510
Psoriasis 91.99 31.13 16 87658 147738 90393035
Haemoglobin decreased 91.59 31.13 22 87652 161934 90378839
Hospitalisation 91.40 31.13 9 87665 128091 90412682
Sepsis 91.34 31.13 30 87644 179784 90360989
Urinary tract infection 90.79 31.13 97 87577 305535 90235238
Oxygen saturation decreased 90.40 31.13 3 87671 107480 90433293
Product prescribing issue 89.88 31.13 69 87605 7910 90532863
COVID-19 89.67 31.13 26 87648 168817 90371956
Renal failure 88.93 31.13 11 87663 130996 90409777
Renal impairment 88.46 31.13 3 87671 105418 90435355
Abnormal withdrawal bleeding 88.44 31.13 19 87655 50 90540723
Ruptured ectopic pregnancy 87.85 31.13 29 87645 514 90540259
Gastrooesophageal reflux disease 87.63 31.13 26 87648 166311 90374462
Cardiac failure 85.72 31.13 5 87669 109491 90431282
Device failure 85.14 31.13 63 87611 6834 90533939
Incorrect route of product administration 84.47 31.13 165 87509 50461 90490312
Bronchitis 84.11 31.13 22 87652 152905 90387868
Medical device site scab 83.19 31.13 14 87660 0 90540773
Respiratory failure 82.73 31.13 9 87665 118409 90422364
Ovarian cyst 81.48 31.13 92 87582 17226 90523547
Lip dry 80.93 31.13 4 87670 100951 90439822
Withdrawal bleed 80.17 31.13 18 87656 62 90540711
Osteoporosis 80.12 31.13 3 87671 96528 90444245
Needle issue 79.56 31.13 82 87592 13852 90526921
Ulnar nerve injury 79.02 31.13 21 87653 166 90540607
Delirium 78.07 31.13 6 87668 104353 90436420
Hypokalaemia 77.79 31.13 16 87658 131100 90409673
Leukopenia 77.63 31.13 5 87669 100705 90440068
Dysphagia 77.26 31.13 9 87665 112269 90428504
Implant site nerve injury 77.25 31.13 13 87661 0 90540773
Blood pressure increased 76.67 31.13 48 87626 197169 90343604
Pelvic pain 76.40 31.13 84 87590 15273 90525500
Sciatica 75.36 31.13 6 87668 101376 90439397
Injection site pain 75.14 31.13 37 87637 173662 90367111
Prescribed overdose 74.80 31.13 5 87669 97620 90443153
Grip strength decreased 73.17 31.13 4 87670 92572 90448201
Wound infection 72.05 31.13 9 87665 106393 90434380
Upper respiratory tract infection 71.44 31.13 18 87656 128300 90412473
Drug-induced liver injury 71.08 31.13 4 87670 90314 90450459
Libido decreased 70.71 31.13 41 87633 2941 90537832
Musculoskeletal pain 70.35 31.13 39 87635 171212 90369561
Injury 70.10 31.13 53 87621 197296 90343477
Herpes zoster 69.25 31.13 6 87668 94638 90446135
Infertility female 68.97 31.13 25 87649 592 90540181
Bradycardia 68.26 31.13 3 87671 83844 90456929
Muscular weakness 67.82 31.13 60 87614 206606 90334167
Influenza 67.68 31.13 25 87649 139239 90401534
Impaired healing 67.68 31.13 76 87598 234123 90306650
Red blood cell sedimentation rate increased 67.09 31.13 3 87671 82592 90458181
Alanine aminotransferase increased 67.05 31.13 16 87658 118322 90422451
Product administration error 66.14 31.13 103 87571 26320 90514453
Tachycardia 66.09 31.13 35 87639 157638 90383135
Emotional disorder 66.05 31.13 77 87597 14920 90525853
Urticaria 62.90 31.13 130 87544 312604 90228169
Tremor 62.75 31.13 35 87639 153138 90387635
Septic shock 62.50 31.13 5 87669 84155 90456618
Aspartate aminotransferase increased 62.23 31.13 12 87662 102925 90437848
Interstitial lung disease 61.33 31.13 3 87671 76402 90464371
Neuropathy peripheral 61.04 31.13 28 87646 136942 90403831
Intentional overdose 61.01 31.13 9 87665 93825 90446948
Administration site discomfort 60.37 31.13 16 87658 125 90540648
Lower limb fracture 58.03 31.13 7 87667 85006 90455767
Night sweats 57.89 31.13 26 87648 128740 90412033
Cataract 57.33 31.13 3 87671 72089 90468684
Peripheral venous disease 57.06 31.13 7 87667 83914 90456859
Productive cough 56.07 31.13 5 87669 77058 90463715
Fluid retention 56.02 31.13 9 87665 88082 90452691
Rectal haemorrhage 56.02 31.13 7 87667 82737 90458036
Cardiac arrest 55.99 31.13 16 87658 104919 90435854
Autoimmune disorder 55.78 31.13 5 87669 76739 90464034
Chills 55.75 31.13 29 87645 131952 90408821
Maternal exposure during breast feeding 55.64 31.13 47 87627 6173 90534600
Adnexa uteri pain 55.36 31.13 20 87654 469 90540304
Amnesia 55.27 31.13 18 87656 108487 90432286
Hypoglycaemia 55.25 31.13 3 87671 69845 90470928
Balance disorder 55.25 31.13 13 87661 97067 90443706
Electrocardiogram QT prolonged 54.67 31.13 4 87670 72452 90468321
Joint stiffness 54.33 31.13 6 87668 78036 90462737
Implant site nodule 53.48 31.13 9 87665 0 90540773
Implant site cyst 53.48 31.13 9 87665 0 90540773
Drug abuse 53.31 31.13 8 87666 82339 90458434
Myocardial infarction 53.24 31.13 18 87656 105954 90434819
Intentional product misuse 53.01 31.13 11 87663 89593 90451180
Poor quality device used 52.98 31.13 31 87643 2262 90538511
Chlamydial infection 52.88 31.13 18 87656 352 90540421
Female sterilisation 52.30 31.13 21 87653 662 90540111
Depressed level of consciousness 52.21 31.13 5 87669 72779 90467994
Overdose 52.20 31.13 295 87379 157414 90383359
Premenstrual syndrome 52.15 31.13 22 87652 788 90539985
Suppressed lactation 52.10 31.13 19 87655 458 90540315
Adverse drug reaction 51.78 31.13 24 87650 116677 90424096
Exploratory operation 50.89 31.13 9 87665 3 90540770
Product shape issue 50.06 31.13 13 87661 93 90540680
Pregnancy test false positive 49.64 31.13 16 87658 262 90540511
Coma 49.53 31.13 6 87668 72626 90468147
Coital bleeding 49.15 31.13 20 87654 653 90540120
Cardio-respiratory arrest 49.06 31.13 3 87671 63137 90477636
Dysphonia 49.01 31.13 3 87671 63081 90477692
Blood glucose increased 48.16 31.13 16 87658 95230 90445543
Unwanted pregnancy 48.03 31.13 13 87661 111 90540662
Nasal congestion 47.80 31.13 11 87663 83403 90457370
Implant site papules 47.54 31.13 8 87666 0 90540773
False negative pregnancy test 47.54 31.13 8 87666 0 90540773
Anaphylactic reaction 47.34 31.13 13 87661 87511 90453262
Colitis 47.15 31.13 6 87668 69936 90470837
Cognitive disorder 46.68 31.13 6 87668 69401 90471372
Rhinorrhoea 46.14 31.13 14 87660 88302 90452471
Heart rate increased 45.94 31.13 26 87648 112876 90427897
Injection site reaction 45.64 31.13 16 87658 92064 90448709
Hepatitis 45.50 31.13 7 87667 70732 90470041
Pleural effusion 45.27 31.13 26 87648 111965 90428808
Vaginal infection 45.20 31.13 48 87626 8392 90532381
Liposuction 44.64 31.13 10 87664 34 90540739
Hallucination 43.64 31.13 6 87668 65953 90474820
Frequent bowel movements 43.36 31.13 3 87671 56932 90483841
Hypercoagulation 43.26 31.13 27 87647 2215 90538558
Visual impairment 42.73 31.13 39 87635 132326 90408447
White blood cell count increased 42.46 31.13 7 87667 67234 90473539
Myalgia 41.26 31.13 66 87608 175059 90365714
Therapeutic response decreased 40.51 31.13 18 87656 89711 90451062
Ear infection 40.39 31.13 9 87665 69766 90471007
Incorrect dose administered 40.36 31.13 13 87661 78917 90461856
Circumstance or information capable of leading to device use error 40.10 31.13 13 87661 217 90540556
Patient-device incompatibility 39.99 31.13 13 87661 219 90540554
Abdominal pain upper 39.73 31.13 176 87498 332498 90208275
Blepharospasm 39.27 31.13 4 87670 55441 90485332
Oropharyngeal pain 38.31 31.13 33 87641 115154 90425619
Infertility 38.03 31.13 18 87656 849 90539924
Laryngitis 37.73 31.13 3 87671 50750 90490023
Product quality control issue 37.53 31.13 8 87666 20 90540753
Chronic kidney disease 37.21 31.13 3 87671 50188 90490585
Dyspnoea exertional 36.80 31.13 12 87662 72276 90468497
Implantation complication 36.72 31.13 8 87666 23 90540750
Flushing 36.55 31.13 20 87654 88471 90452302
Respiratory disorder 36.25 31.13 9 87665 64807 90475966
Intentional medical device removal by patient 36.19 31.13 11 87663 147 90540626
Bone pain 35.86 31.13 8 87666 61975 90478798
Device extrusion 35.75 31.13 8 87666 27 90540746
Chest discomfort 35.65 31.13 49 87625 138316 90402457
Loss of libido 35.65 31.13 20 87654 1347 90539426
Sedation 35.38 31.13 3 87671 48168 90492605
Gastric bypass 35.31 31.13 23 87651 2031 90538742
Foreign body reaction 35.10 31.13 10 87664 105 90540668
Smear cervix abnormal 35.01 31.13 27 87647 3115 90537658
Ectopic pregnancy termination 34.99 31.13 7 87667 11 90540762
Ascites 34.99 31.13 3 87671 47737 90493036
Abortion of ectopic pregnancy 34.82 31.13 9 87665 63 90540710
Pulmonary infarction 34.76 31.13 26 87648 2866 90537907
Erythema 34.72 31.13 110 87564 229136 90311637
Breast discharge 34.42 31.13 19 87655 1240 90539533
Hypoaesthesia 34.27 31.13 459 87215 313751 90227022
Multiple sclerosis relapse 34.04 31.13 5 87669 52300 90488473
Vulvovaginal mycotic infection 33.97 31.13 36 87638 6278 90534495
Blood pressure decreased 33.85 31.13 15 87659 74880 90465893
Red blood cell count decreased 33.74 31.13 3 87671 46348 90494425
Cervical dysplasia 33.07 31.13 29 87645 4005 90536768
Injection site erythema 33.02 31.13 28 87646 98474 90442299
Metabolic surgery 32.60 31.13 20 87654 1591 90539182
Colitis ulcerative 32.50 31.13 9 87665 60257 90480516
Haematochezia 32.37 31.13 14 87660 70899 90469874
Ear pain 32.29 31.13 8 87666 57694 90483079
Dizziness 32.21 31.13 390 87284 588894 89951879
Coeliac disease 32.17 31.13 3 87671 44607 90496166
Joint dislocation 32.14 31.13 3 87671 44579 90496194
Therapy interrupted 32.13 31.13 5 87669 50103 90490670
Implant site extravasation 31.95 31.13 14 87660 551 90540222
Injection site bruising 31.82 31.13 6 87668 52301 90488472
Neck pain 31.80 31.13 38 87636 113925 90426848
Pancreatitis 31.53 31.13 14 87660 69812 90470961
Hyperhidrosis 31.51 31.13 52 87622 136253 90404520
Epistaxis 31.33 31.13 22 87652 85103 90455670
Anembryonic gestation 31.32 31.13 14 87660 578 90540195
Dyspareunia 31.18 31.13 24 87650 2762 90538011

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Complication associated with device 12568.84 37.49 2737 55040 17336 110514186
No adverse event 12098.32 37.49 3429 54348 70410 110461112
Device deployment issue 8405.35 37.49 1517 56260 2736 110528786
Complication of device removal 8344.70 37.49 1527 56250 3093 110528429
Device difficult to use 8239.51 37.49 1918 55859 16887 110514635
Pregnancy with implant contraceptive 8129.20 37.49 1353 56424 1019 110530503
Unintended pregnancy 7988.52 37.49 1481 56296 3327 110528195
Complication of device insertion 7707.21 37.49 1587 56190 7251 110524271
Device breakage 7568.16 37.49 1690 56087 12079 110519443
Product quality issue 7377.36 37.49 2372 55405 74927 110456595
Incorrect product administration duration 7267.21 37.49 1762 56015 18736 110512786
Implant site pain 6626.62 37.49 1125 56652 1090 110530432
Device dislocation 4849.55 37.49 1401 56376 30303 110501219
Device kink 4433.57 37.49 790 56987 1259 110530263
Device expulsion 4059.67 37.49 1214 56563 29677 110501845
Heavy menstrual bleeding 3990.20 37.49 1044 56733 15321 110516201
Menstruation irregular 3452.71 37.49 761 57016 5036 110526486
Intermenstrual bleeding 2934.60 37.49 689 57088 6245 110525277
Amenorrhoea 2629.58 37.49 667 57110 8564 110522958
Device placement issue 2276 37.49 442 57335 1375 110530147
Vaginal haemorrhage 2026.58 37.49 681 57096 24393 110507129
Implant site erythema 1926.72 37.49 323 57454 263 110531259
Implant site pruritus 1686.17 37.49 286 57491 270 110531252
Device issue 1332.84 37.49 545 57232 33990 110497532
Implant site bruising 1262.81 37.49 208 57569 131 110531391
Implant site scar 1246.83 37.49 199 57578 68 110531454
Implant site swelling 1223.03 37.49 215 57562 299 110531223
Implant site fibrosis 1097.82 37.49 169 57608 11 110531511
General anaesthesia 1025.52 37.49 163 57614 50 110531472
Implant site infection 989.97 37.49 228 57549 1875 110529647
Abortion spontaneous 818.28 37.49 386 57391 33896 110497626
Abortion induced 764.67 37.49 247 57530 7772 110523750
Implant site irritation 756.30 37.49 118 57659 19 110531503
Menstrual disorder 723.40 37.49 210 57567 4574 110526948
Menstruation delayed 679.01 37.49 163 57614 1631 110529891
Medical device removal 668.56 37.49 139 57638 662 110530860
Mood swings 622.76 37.49 282 57495 22530 110508992
Medical device site discomfort 614.76 37.49 108 57669 149 110531373
Menometrorrhagia 595.02 37.49 129 57648 777 110530745
Dysmenorrhoea 561.51 37.49 162 57615 3448 110528074
Device embolisation 556.48 37.49 90 57687 41 110531481
Polymenorrhoea 516.98 37.49 120 57657 1024 110530498
Off label use 505.37 37.49 89 57688 1500096 109031426
Implant site rash 486.35 37.49 83 57694 84 110531438
Hypomenorrhoea 450.25 37.49 92 57685 395 110531127
Menstruation normal 425.86 37.49 67 57710 15 110531507
Diarrhoea 384.41 37.49 67 57710 1139438 109392084
Implant site hypoaesthesia 381.21 37.49 59 57718 6 110531516
Implant site reaction 373.62 37.49 66 57711 96 110531426
Implant site haemorrhage 372.90 37.49 69 57708 150 110531372
Weight increased 363.57 37.49 725 57052 418919 110112603
Implant site discharge 361.59 37.49 65 57712 111 110531411
Implant site cellulitis 360.86 37.49 61 57716 55 110531467
Pneumonia 347.86 37.49 30 57747 876684 109654838
Death 316.69 37.49 11 57766 698858 109832664
Surgery 315.17 37.49 221 57556 41062 110490460
Implant site mass 305.68 37.49 50 57727 28 110531494
Oligomenorrhoea 300.29 37.49 74 57703 833 110530689
Pregnancy with contraceptive device 291.29 37.49 100 57677 3807 110527715
Drug ineffective 289.68 37.49 224 57553 1520316 109011206
Implant site paraesthesia 288.55 37.49 44 57733 0 110531522
Acute kidney injury 281.03 37.49 12 57765 635418 109896104
Pyrexia 277.22 37.49 65 57712 898200 109633322
Condition aggravated 275.99 37.49 31 57746 734805 109796717
Implant site inflammation 269.56 37.49 55 57722 234 110531288
Dyspnoea 254.51 37.49 131 57646 1106741 109424781
Breast tenderness 234.14 37.49 77 57700 2563 110528959
Toxicity to various agents 231.04 37.49 4 57773 480551 110050971
Implant site discolouration 230.54 37.49 36 57741 6 110531516
Wrong technique in device usage process 222.74 37.49 96 57681 6805 110524717
Implant site warmth 221.52 37.49 35 57742 9 110531513
Acne 213.87 37.49 161 57616 33359 110498163
Implant site vesicles 213.44 37.49 34 57743 11 110531511
Pregnancy on contraceptive 210.56 37.49 57 57720 951 110530571
Hypotension 210.02 37.49 17 57760 523832 110007690
Medical device discomfort 209.49 37.49 66 57711 1910 110529612
Implant site abscess 203.34 37.49 35 57742 39 110531483
Fall 201.85 37.49 36 57741 603446 109928076
Mood altered 200.38 37.49 130 57647 21245 110510277
Infusion related reaction 183.88 37.49 3 57774 381159 110150363
Implant site induration 183.62 37.49 28 57749 0 110531522
Implant site urticaria 183.11 37.49 29 57748 8 110531514
General physical health deterioration 181.58 37.49 10 57767 425285 110106237
Fatigue 181.36 37.49 222 57555 1215736 109315786
Arthralgia 179.30 37.49 92 57685 779540 109751982
Implant site injury 177.06 37.49 27 57750 0 110531522
Haemorrhage 175.27 37.49 246 57531 106446 110425076
Breast pain 174.32 37.49 91 57686 9909 110521613
Neutropenia 172.70 37.49 5 57772 374615 110156907
Expired product administered 172.13 37.49 85 57692 8235 110523287
Joint swelling 170.38 37.49 17 57760 442828 110088694
Drug intolerance 169.17 37.49 11 57766 406501 110125021
Confusional state 165.54 37.49 24 57753 468656 110062866
Ectopic pregnancy with contraceptive device 163.72 37.49 49 57728 1189 110530333
Thrombocytopenia 163.27 37.49 4 57773 348881 110182641
Ectopic pregnancy 152.78 37.49 54 57723 2243 110529279
Implant site oedema 146.36 37.49 24 57753 14 110531508
Pain in extremity 144.99 37.49 570 57207 486548 110044974
Drug hypersensitivity 143.52 37.49 31 57746 454059 110077463
Cough 139.00 37.49 35 57742 461606 110069916
Anaemia 137.38 37.49 57 57720 547029 109984493
Hypertension 128.29 37.49 53 57724 510031 110021491
Rheumatoid arthritis 127.97 37.49 7 57770 299606 110231916
Vomiting 127.55 37.49 174 57603 910501 109621021
Application site discomfort 127.14 37.49 32 57745 395 110531127
Hepatic enzyme increased 126.90 37.49 11 57766 320881 110210641
Nasopharyngitis 126.50 37.49 26 57751 394335 110137187
Arthropathy 125.07 37.49 6 57771 287516 110244006
Asthenia 124.93 37.49 106 57671 688893 109842629
Pulmonary embolism 124.04 37.49 316 57461 214158 110317364
Implant site pustules 121.81 37.49 19 57758 3 110531519
Vaginal discharge 120.89 37.49 89 57688 17819 110513703
Circumstance or information capable of leading to medication error 118.89 37.49 57 57720 5176 110526346
Inappropriate schedule of product administration 118.76 37.49 301 57476 203336 110328186
Constipation 115.97 37.49 23 57754 357763 110173759
Sinusitis 115.08 37.49 11 57766 296677 110234845
Rash 113.76 37.49 158 57619 820806 109710716
Lower respiratory tract infection 112.91 37.49 3 57774 243103 110288419
Musculoskeletal stiffness 112.27 37.49 9 57768 279813 110251709
Implant site necrosis 110.74 37.49 18 57759 9 110531513
Sepsis 110.47 37.49 19 57758 327327 110204195
Wheezing 108.88 37.49 6 57771 255224 110276298
Systemic lupus erythematosus 108.43 37.49 6 57771 254332 110277190
Treatment failure 108.27 37.49 10 57767 277224 110254298
Malaise 105.93 37.49 117 57660 671702 109859820
White blood cell count decreased 105.90 37.49 3 57774 229387 110302135
Intentional product use issue 102.22 37.49 7 57770 247899 110283623
Decreased appetite 102.21 37.49 61 57716 475785 110055737
Dehydration 101.74 37.49 13 57764 279498 110252024
Gait disturbance 101.12 37.49 13 57764 278195 110253327
C-reactive protein increased 100.05 37.49 3 57774 217916 110313606
Abnormal uterine bleeding 99.99 37.49 35 57742 1412 110530110
Hyponatraemia 99.91 37.49 3 57774 217650 110313872
Platelet count decreased 99.60 37.49 5 57772 230438 110301084
Abortion 99.14 37.49 36 57741 1618 110529904
Encapsulation reaction 98.37 37.49 15 57762 0 110531522
Therapeutic product effect decreased 97.61 37.49 8 57769 244308 110287214
Atrial fibrillation 96.12 37.49 6 57771 229636 110301886
Limb discomfort 95.08 37.49 112 57665 40742 110490780
Oedema peripheral 94.94 37.49 27 57750 328633 110202889
Renal failure 94.59 37.49 6 57771 226568 110304954
Therapeutic product effect incomplete 93.21 37.49 6 57771 223799 110307723
Breast feeding 92.98 37.49 28 57749 694 110530828
Device use issue 91.42 37.49 43 57734 3741 110527781
Abdominal discomfort 91.08 37.49 46 57731 393812 110137710
Hormone level abnormal 89.80 37.49 37 57740 2343 110529179
Haemoglobin decreased 89.48 37.49 12 57765 248715 110282807
Implant site haematoma 89.36 37.49 21 57756 190 110531332
Dry mouth 87.50 37.49 4 57773 199944 110331578
Implant site hypersensitivity 86.55 37.49 15 57762 18 110531504
Respiratory failure 86.16 37.49 7 57770 215325 110316197
Psoriatic arthropathy 85.90 37.49 4 57773 196757 110334765
Renal impairment 85.06 37.49 3 57774 188442 110343080
Somnolence 84.87 37.49 25 57752 297424 110234098
Gastrointestinal disorder 83.95 37.49 13 57764 241939 110289583
Hypoaesthesia 83.27 37.49 355 57422 313868 110217654
Contraindicated product administered 82.46 37.49 15 57762 248252 110283270
Osteoarthritis 82.11 37.49 3 57774 182620 110348902
Cardiac failure 81.31 37.49 4 57773 187622 110343900
Vulvovaginal discomfort 80.07 37.49 33 57744 2091 110529431
Drug abuse 79.47 37.49 3 57774 177408 110354114
Deep vein thrombosis 77.62 37.49 203 57574 139684 110391838
Type 2 diabetes mellitus 76.10 37.49 4 57773 177228 110354294
Scar 75.69 37.49 66 57711 16815 110514707
Device failure 75.43 37.49 47 57730 7160 110524362
COVID-19 74.82 37.49 18 57759 245042 110286480
Incorrect route of product administration 74.58 37.49 126 57651 63935 110467587
Arthritis 74.50 37.49 3 57774 167583 110363939
Ovarian cyst 73.87 37.49 60 57717 13870 110517652
Fibromyalgia 72.93 37.49 4 57773 170905 110360617
Infection 72.85 37.49 50 57727 362150 110169372
Implant site nerve injury 72.13 37.49 11 57766 0 110531522
Ruptured ectopic pregnancy 72.02 37.49 21 57756 464 110531058
Withdrawal bleed 71.69 37.49 14 57763 45 110531477
Blood cholesterol increased 71.24 37.49 7 57770 184778 110346744
Therapy non-responder 69.31 37.49 3 57774 157304 110374218
Ill-defined disorder 69.08 37.49 3 57774 156850 110374672
Gastrooesophageal reflux disease 68.91 37.49 7 57770 179969 110351553
Bradycardia 68.41 37.49 3 57774 155514 110376008
Wrong technique in product usage process 68.35 37.49 145 57632 87203 110444319
Asthma 67.89 37.49 23 57754 250268 110281254
Hypokalaemia 67.56 37.49 8 57769 182440 110349082
Product administration error 67.39 37.49 90 57687 37127 110494395
Adnexa uteri pain 67.33 37.49 19 57758 372 110531150
Cardiac arrest 67.28 37.49 11 57766 196742 110334780
Irritable bowel syndrome 66.64 37.49 5 57772 164210 110367312
Abnormal withdrawal bleeding 66.29 37.49 13 57764 43 110531479
Septic shock 66.26 37.49 4 57773 157524 110373998
Liver injury 65.84 37.49 3 57774 150410 110381112
Memory impairment 65.18 37.49 12 57765 196932 110334590
Inflammation 63.47 37.49 12 57765 193226 110338296
Myocardial infarction 62.94 37.49 12 57765 192071 110339451
Maternal exposure before pregnancy 62.77 37.49 42 57735 7223 110524299
Mobility decreased 62.37 37.49 23 57754 237399 110294123
Leukopenia 61.91 37.49 4 57773 148787 110382735
Hospitalisation 61.86 37.49 3 57774 142490 110389032
Uterine haemorrhage 61.48 37.49 32 57745 3462 110528060
Dysphagia 61.42 37.49 5 57772 153595 110377927
Oedema 61.08 37.49 17 57760 209959 110321563
Medical device site scab 60.88 37.49 10 57767 6 110531516
Tachycardia 59.46 37.49 22 57755 226623 110304899
Wound 59.45 37.49 24 57753 234413 110297109
Premenstrual syndrome 59.12 37.49 19 57758 587 110530935
Liver disorder 58.67 37.49 4 57773 142239 110389283
Needle issue 57.38 37.49 58 57719 17782 110513740
Alanine aminotransferase increased 57.08 37.49 13 57764 183760 110347762
Loss of personal independence in daily activities 57.00 37.49 6 57771 150014 110381508
Blister 56.49 37.49 24 57753 227352 110304170
Sleep disorder 56.09 37.49 17 57760 198627 110332895
Gait inability 55.77 37.49 4 57773 136372 110395150
Maternal exposure during breast feeding 55.69 37.49 32 57745 4206 110527316
Pelvic pain 55.29 37.49 54 57723 15888 110515634
Hypersensitivity 54.58 37.49 79 57698 403919 110127603
Infertility female 54.18 37.49 17 57760 485 110531037
Ulnar nerve injury 53.78 37.49 15 57762 281 110531241
Emotional disorder 52.82 37.49 53 57724 16107 110515415
Adverse event 52.46 37.49 150 57627 108659 110422863
Implant site nodule 52.46 37.49 8 57769 0 110531522
Aspartate aminotransferase increased 52.38 37.49 10 57767 159926 110371596
Suppressed lactation 51.99 37.49 15 57762 319 110531203
Neuropathy peripheral 51.24 37.49 15 57762 179262 110352260
Dyspepsia 51.00 37.49 18 57759 190947 110340575
Unwanted pregnancy 50.12 37.49 10 57767 37 110531485
Administration site discomfort 49.94 37.49 13 57764 185 110531337
Delirium 49.79 37.49 6 57771 135019 110396503
Pruritus 48.88 37.49 149 57628 581411 109950111
Intentional product misuse 48.78 37.49 6 57771 132898 110398624
Drug-induced liver injury 47.75 37.49 4 57773 120063 110411459
Chills 47.52 37.49 20 57757 190560 110340962
Keloid scar 47.52 37.49 13 57764 226 110531296
Pleural effusion 47.03 37.49 17 57760 177692 110353830
Depressed level of consciousness 46.77 37.49 3 57774 112275 110419247
Blood pressure increased 46.41 37.49 40 57737 258333 110273189
Intentional overdose 46.22 37.49 7 57770 132494 110399028
Bronchitis 45.13 37.49 13 57764 157019 110374503
Swelling 45.13 37.49 71 57706 350970 110180552
Productive cough 44.93 37.49 4 57773 114301 110417221
Musculoskeletal pain 44.38 37.49 20 57757 183003 110348519
Coma 44.05 37.49 5 57772 117864 110413658
Urinary tract infection 43.87 37.49 64 57713 326218 110205304
Female sterilisation 43.22 37.49 13 57764 321 110531201
Insomnia 42.60 37.49 77 57700 360513 110171009
Rectal haemorrhage 42.56 37.49 6 57771 119827 110411695
Electrocardiogram QT prolonged 42.33 37.49 4 57773 108956 110422566
Ectopic pregnancy termination 42.13 37.49 7 57770 5 110531517
Vaginal infection 41.88 37.49 32 57745 6772 110524750
Poor quality device used 41.36 37.49 23 57754 2840 110528682
Psoriasis 41.33 37.49 11 57766 139982 110391540
Coital bleeding 40.62 37.49 13 57764 396 110531126
Herpes zoster 39.51 37.49 5 57772 108374 110423148
False negative pregnancy test 39.35 37.49 6 57771 0 110531522
Tremor 39.21 37.49 29 57748 202203 110329319
Abortion missed 38.78 37.49 18 57759 1519 110530003
Balance disorder 38.78 37.49 7 57770 116553 110414969
Hallucination 38.68 37.49 4 57773 101428 110430094
Paraesthesia 38.55 37.49 262 57515 276259 110255263
Lip dry 38.03 37.49 4 57773 100079 110431443
Upper respiratory tract infection 37.50 37.49 11 57766 131317 110400205

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03AC08 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens
FDA CS M0447349 Progesterone Congeners
MeSH PA D000080066 Contraceptive Agents, Hormonal
MeSH PA D003270 Contraceptive Agents
MeSH PA D003271 Contraceptive Agents, Female
MeSH PA D012102 Reproductive Control Agents
FDA EPC N0000175602 Progestin
CHEBI has role CHEBI:49323 contraceptive drug
CHEBI has role CHEBI:49324 female contraceptive drug
CHEBI has role CHEBI:59826 progestin
CHEBI has role CHEBI:64946 anti-HIV agent

Related Drugs by ATC class:

G03AC Progestogens 9 drugs
desogestreldrospirenonelevonorgestrellynestrenolmedroxyprogesteronemegestrol acetatenorethisteronenorgestrienonequingestanol acetate

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Contraception indication 13197004
Heart valve disorder contraindication 368009 DOID:4079
Hypercholesterolemia contraindication 13644009
Toxic shock syndrome contraindication 18504008 DOID:14115
Myocardial infarction contraindication 22298006 DOID:5844
Diplopia contraindication 24982008
Retinal hemorrhage contraindication 28998008
Depressive disorder contraindication 35489007
Migraine contraindication 37796009 DOID:6364
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Body fluid retention contraindication 43498006
Thrombosis of retinal vein contraindication 46085004
Chronic heart failure contraindication 48447003
Dementia contraindication 52448006
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Hyperlipidemia contraindication 55822004 DOID:1168
Cerebrovascular disease contraindication 62914000 DOID:6713
Thrombophlebitis contraindication 64156001 DOID:3875
Intermenstrual bleeding - irregular contraindication 64996003
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Malignant neoplasm of liver contraindication 93870000 DOID:3571
Deep venous thrombosis contraindication 128053003
Seizure disorder contraindication 128613002
Bed-ridden contraindication 160685001
Asthma contraindication 195967001 DOID:2841
Cerebrovascular accident contraindication 230690007
Pulmonary thromboembolism contraindication 233935004
Disease of liver contraindication 235856003 DOID:409
Cholestasis of pregnancy contraindication 235888006
Metabolic syndrome X contraindication 237602007 DOID:14221
Endometrial carcinoma contraindication 254878006 DOID:2871
Pregnancy, function contraindication 289908002
Hypertriglyceridemia contraindication 302870006
Functional visual loss contraindication 313165001
Non-Q wave myocardial infarction contraindication 314207007
Malignant tumor of ovary contraindication 363443007 DOID:2394
Thromboembolic disorder contraindication 371039008
Disorder of coronary artery contraindication 414024009
Obesity contraindication 414916001 DOID:9970
Estrogen receptor positive tumor contraindication 416053008
Porphyria contraindication 418470004
Optic disc edema contraindication 423341008 DOID:146
Hypertensive urgency contraindication 443482000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002
Worsening Headache Disorder contraindication
Major Surgery with Prolonged Post-Operative Immobilization contraindication
Diabetes with Vascular Disease Complication contraindication
Benign Hepatic Cell Adenoma contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.93 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
68MG/IMPLANT IMPLANON ORGANON N021529 July 17, 2006 DISCN IMPLANT IMPLANTATION 9757552 July 28, 2030 PREVENTION OF PREGNANCY
68MG/IMPLANT NEXPLANON ORGANON N021529 May 13, 2011 RX IMPLANT IMPLANTATION 9757552 July 28, 2030 PREVENTION OF PREGNANCY

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
68MG/IMPLANT NEXPLANON ORGANON N021529 May 13, 2011 RX IMPLANT IMPLANTATION Jan. 16, 2029 EXTENSION OF THE DURATION OF USE FROM 3 YEARS TO 5 YEARS

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Progesterone receptor Nuclear hormone receptor AGONIST WOMBAT-PK CHEMBL
Estrogen receptor Nuclear hormone receptor WOMBAT-PK
Sex hormone-binding globulin Secreted Kd 8.23 CHEMBL

External reference:

IDSource
4021294 VUID
N0000179018 NUI
D04104 KEGG_DRUG
4021294 VANDF
C0047683 UMLSCUI
CHEBI:50777 CHEBI
CHEMBL1531 ChEMBL_ID
CHEMBL1697750 ChEMBL_ID
DB00294 DRUGBANK_ID
C044815 MESH_SUPPLEMENTAL_RECORD_UI
6917715 PUBCHEM_CID
7590 IUPHAR_LIGAND_ID
6832 INN_ID
304GTH6RNH UNII
14584 RXNORM
16189 MMSL
51895 MMSL
d04772 MMSL
007906 NDDF
326451000 SNOMEDCT_US
396050000 SNOMEDCT_US
304GTH6RNH INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Etonogestrel and Ethinyl Estradiol HUMAN PRESCRIPTION DRUG LABEL 2 0093-7679 INSERT, EXTENDED RELEASE 0.12 mg VAGINAL ANDA 29 sections
Etonogestrel and Ethinyl Estradiol Vaginal Ring HUMAN PRESCRIPTION DRUG LABEL 2 16714-029 RING 0.12 mg VAGINAL ANDA 22 sections
Etonogestrel and Ethinyl Estradiol Vaginal HUMAN PRESCRIPTION DRUG LABEL 2 42291-478 RING 0.12 mg VAGINAL ANDA 21 sections
NUVARING HUMAN PRESCRIPTION DRUG LABEL 2 50090-1008 INSERT, EXTENDED RELEASE 0.12 mg VAGINAL NDA 27 sections
NUVARING HUMAN PRESCRIPTION DRUG LABEL 2 50090-5611 INSERT, EXTENDED RELEASE 0.12 mg VAGINAL NDA 28 sections
Etonogestrel/Ethinyl Estradiol HUMAN PRESCRIPTION DRUG LABEL 2 50090-5959 INSERT, EXTENDED RELEASE 0.12 mg VAGINAL NDA AUTHORIZED GENERIC 29 sections
NUVARING HUMAN PRESCRIPTION DRUG LABEL 2 50090-7663 INSERT, EXTENDED RELEASE 0.12 mg VAGINAL NDA 28 sections
NuvaRing HUMAN PRESCRIPTION DRUG LABEL 2 54868-4832 INSERT, EXTENDED RELEASE 11.70 mg VAGINAL NDA 25 sections
NuvaRing HUMAN PRESCRIPTION DRUG LABEL 2 59212-146 INSERT, EXTENDED RELEASE 0.12 mg VAGINAL NDA 29 sections
EluRyng HUMAN PRESCRIPTION DRUG LABEL 2 65162-469 RING 0.12 mg VAGINAL ANDA 29 sections
Etonogestrel/Ethinyl Estradiol HUMAN PRESCRIPTION DRUG LABEL 2 66993-605 INSERT, EXTENDED RELEASE 0.12 mg VAGINAL NDA AUTHORIZED GENERIC 30 sections
EnilloRing HUMAN PRESCRIPTION DRUG LABEL 2 70700-156 RING 0.12 mg VAGINAL ANDA 22 sections
HALOETTE HUMAN PRESCRIPTION DRUG LABEL 2 75907-088 INSERT, EXTENDED RELEASE 0.12 mg VAGINAL ANDA 34 sections
NuvaRing HUMAN PRESCRIPTION DRUG LABEL 2 76413-131 INSERT, EXTENDED RELEASE 0.12 mg VAGINAL NDA 28 sections
Nexplanon HUMAN PRESCRIPTION DRUG LABEL 1 78206-145 IMPLANT 68 mg SUBCUTANEOUS NDA 30 sections
NuvaRing HUMAN PRESCRIPTION DRUG LABEL 2 78206-146 INSERT, EXTENDED RELEASE 0.12 mg VAGINAL NDA 29 sections