medroxyprogesterone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids, progestogens 1659 71-58-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • medroxyprogesterone
  • medroxyprogesterone acetate
  • medoxyprogesterone
  • medroxyprogesteron
  • depomedroxyprogesterone acetate
  • medroprogesterone acetate
A synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
  • Molecular weight: 386.53
  • Formula: C24H34O4
  • CLOGP: 4.20
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 60.44
  • ALOGS: -5.24
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.67 mg P
5 mg O
7 mg P
1 g O
1 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.02 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 44 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.06 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 15 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
June 18, 1959 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Unintended pregnancy 1944.16 10.19 489 34533 4457 50565645
Pregnancy with injectable contraceptive 643.78 10.19 107 34915 32 50570070
Intermenstrual bleeding 398.39 10.19 157 34865 6657 50563445
Heavy menstrual bleeding 269.63 10.19 155 34867 15382 50554720
Injection site abscess 227.94 10.19 65 34957 984 50569118
Amenorrhoea 200.94 10.19 104 34918 8380 50561722
Drug dose omission by device 196.53 10.19 73 34949 2626 50567476
Vaginal haemorrhage 180.97 10.19 144 34878 24407 50545695
Breast cancer 178.06 10.19 182 34840 42708 50527394
Osteopenia 161.27 10.19 116 34906 16902 50553200
Depression 140.95 10.19 336 34686 165087 50405015
Incorrect dose administered by device 119.58 10.19 55 34967 3420 50566682
Syringe issue 110.05 10.19 45 34977 2099 50568003
Oestrogen receptor assay positive 107.82 10.19 30 34992 413 50569689
Fibrocystic breast disease 100.26 10.19 35 34987 1049 50569053
Needle issue 98.75 10.19 62 34960 7213 50562889
Injection site atrophy 90.26 10.19 27 34995 487 50569615
Breast cancer female 89.44 10.19 57 34965 6805 50563297
Progesterone receptor assay positive 85.34 10.19 23 34999 279 50569823
Device leakage 84.60 10.19 52 34970 5826 50564276
Death 83.60 10.19 62 34960 325317 50244785
Contraindicated product administered 83.10 10.19 5 35017 148953 50421149
Pelvic pain 83.09 10.19 66 34956 11147 50558955
Uterine perforation 82.90 10.19 53 34969 6362 50563740
Menstruation irregular 82.35 10.19 52 34970 6110 50563992
Breast cancer in situ 80.22 10.19 32 34990 1399 50568703
Device issue 79.68 10.19 83 34939 19889 50550213
Injury 78.88 10.19 130 34892 48795 50521307
Pulmonary embolism 74.32 10.19 195 34827 101509 50468593
Dysmenorrhoea 73.86 10.19 39 34983 3271 50566831
Uterine leiomyoma 72.94 10.19 53 34969 7838 50562264
Breast calcifications 68.84 10.19 27 34995 1128 50568974
Anxiety 67.29 10.19 272 34750 177334 50392768
Glossodynia 67.22 10.19 3 35019 115566 50454536
Uterine haemorrhage 67.16 10.19 37 34985 3378 50566724
Treatment failure 65.13 10.19 9 35013 137628 50432474
Rheumatoid arthritis 62.57 10.19 31 34991 202519 50367583
Postmenopausal haemorrhage 60.90 10.19 29 34993 1951 50568151
Breast tenderness 59.43 10.19 29 34993 2059 50568043
Clear cell renal cell carcinoma 57.51 10.19 24 34998 1179 50568923
Joint swelling 56.43 10.19 52 34970 245234 50324868
Emotional distress 55.69 10.19 83 34939 28580 50541522
Device occlusion 54.64 10.19 40 34982 5983 50564119
Abortion spontaneous 54.33 10.19 101 34921 41671 50528431
Drug intolerance 50.92 10.19 46 34976 219058 50351044
Pyrexia 50.80 10.19 118 34904 380085 50190017
Injection site necrosis 50.35 10.19 22 35000 1211 50568891
Deep vein thrombosis 49.94 10.19 137 34885 73167 50496935
Systemic lupus erythematosus 49.03 10.19 18 35004 140604 50429498
Off label use 48.81 10.19 167 34855 474259 50095843
Infertility female 48.06 10.19 17 35005 530 50569572
Suppressed lactation 47.98 10.19 16 35006 416 50569686
Incorrect dose administered 47.38 10.19 104 34918 48310 50521792
Product quality issue 47.06 10.19 80 34942 30778 50539324
Renal mass 46.81 10.19 24 34998 1894 50568208
Hot flush 45.64 10.19 97 34925 44072 50526030
Breast cancer metastatic 44.83 10.19 45 34977 10319 50559783
Toxicity to various agents 44.35 10.19 49 34973 212450 50357652
Genital haemorrhage 43.03 10.19 36 34986 6538 50563564
Uterine polyp 42.79 10.19 22 35000 1746 50568356
Product administration error 41.10 10.19 59 34963 19640 50550462
Hepatic enzyme increased 40.95 10.19 22 35000 137358 50432744
Abdominal discomfort 40.51 10.19 61 34961 231580 50338522
Osteoporosis 40.11 10.19 93 34929 44786 50525316
Breast disorder 40.02 10.19 22 35000 2000 50568102
Synovitis 38.16 10.19 19 35003 123846 50446256
Diarrhoea 38.13 10.19 245 34777 588231 49981871
Acute kidney injury 38.03 10.19 62 34960 227996 50342106
Endometrial hyperplasia 36.13 10.19 15 35007 727 50569375
Pneumonia 35.69 10.19 138 34884 378263 50191839
Lower respiratory tract infection 35.24 10.19 11 35011 95190 50474912
Menstrual disorder 35.14 10.19 27 34995 4343 50565759
Therapeutic product effect decreased 34.76 10.19 26 34996 136024 50434078
Incorrect route of product administration 34.76 10.19 53 34969 18613 50551489
Cholecystitis chronic 34.70 10.19 38 34984 9631 50560471
Sepsis 34.49 10.19 25 34997 132900 50437202
Wound 34.48 10.19 15 35007 105779 50464323
Infusion related reaction 34.38 10.19 40 34982 169517 50400585
Peripheral swelling 34.32 10.19 56 34966 205880 50364222
Injection site pain 34.30 10.19 160 34862 110864 50459238
Mammogram abnormal 34.13 10.19 14 35008 658 50569444
Poor quality product administered 33.26 10.19 22 35000 2797 50567305
Hyperlipidaemia 33.05 10.19 50 34972 17440 50552662
Device dislocation 33.04 10.19 56 34966 21490 50548612
Mood altered 32.31 10.19 42 34980 12731 50557371
Mood swings 32.14 10.19 47 34975 15907 50554195
Gastrooesophageal reflux disease 32.09 10.19 121 34901 76307 50493795
Spinal osteoarthritis 32.06 10.19 44 34978 14048 50556054
Scar 31.69 10.19 40 34982 11778 50558324
Injection site panniculitis 31.38 10.19 5 35017 0 50570102
Endometrial cancer 30.43 10.19 21 35001 2862 50567240
Cerebrovascular accident 30.39 10.19 138 34884 94542 50475560
Exostosis of jaw 29.02 10.19 15 35007 1204 50568898
Discomfort 28.61 10.19 20 35002 108360 50461742
Infertility 28.54 10.19 12 35010 601 50569501
Injection site inflammation 28.43 10.19 21 35001 3184 50566918
Pregnancy test positive 28.30 10.19 8 35014 117 50569985
Breast mass 27.89 10.19 28 34994 6421 50563681
Neutropenia 27.80 10.19 37 34985 147928 50422174
Bone density decreased 27.37 10.19 36 34986 11039 50559063
Ectopic pregnancy 27.06 10.19 18 35004 2309 50567793
Suicidal ideation 26.92 10.19 92 34930 55293 50514809
Procedural pain 26.79 10.19 40 34982 13792 50556310
Cervical dysplasia 26.41 10.19 19 35003 2766 50567336
Low turnover osteopathy 26.41 10.19 22 35000 3972 50566130
Stomatitis 26.36 10.19 19 35003 101325 50468777
Eosinopenia 26.15 10.19 6 35016 35 50570067
Infection 26.12 10.19 50 34972 172904 50397198
Wrong technique in device usage process 25.98 10.19 18 35004 2468 50567634
Breast hyperplasia 25.93 10.19 9 35013 265 50569837
Coronary artery disease 25.90 10.19 61 34961 29665 50540437
Pericarditis 25.89 10.19 11 35011 78678 50491424
Injection site indentation 25.83 10.19 8 35014 163 50569939
Scoliosis 25.63 10.19 27 34995 6549 50563553
Fatigue 25.61 10.19 341 34681 707260 49862842
Therapeutic product effect incomplete 25.35 10.19 16 35006 91499 50478603
Migraine 25.11 10.19 111 34911 75169 50494933
Intervertebral disc degeneration 24.75 10.19 38 34984 13423 50556679
Confusional state 24.53 10.19 58 34964 185870 50384232
Stress urinary incontinence 24.08 10.19 16 35006 2049 50568053
Device failure 23.90 10.19 24 34998 5504 50564598
Abdominal pain lower 23.89 10.19 49 34973 21707 50548395
Hyponatraemia 23.75 10.19 19 35003 96120 50473982
Completed suicide 23.75 10.19 34 34988 131855 50438247
Abnormal uterine bleeding 23.33 10.19 13 35009 1213 50568889
Dyspareunia 23.30 10.19 16 35006 2163 50567939
Poor quality device used 23.19 10.19 15 35007 1836 50568266
Breast cyst 23.09 10.19 14 35008 1530 50568572
Urticaria 22.98 10.19 161 34861 129400 50440702
Haemorrhage 22.75 10.19 85 34937 53356 50516746
Cerebral venous sinus thrombosis 22.09 10.19 14 35008 1654 50568448
Product complaint 21.98 10.19 33 34989 11433 50558669
Biopsy breast abnormal 21.97 10.19 5 35017 28 50570074
Breast conserving surgery 21.75 10.19 11 35011 843 50569259
Swelling 21.75 10.19 69 34953 200803 50369299
Embedded device 21.66 10.19 17 35005 2820 50567282
Musculoskeletal stiffness 21.33 10.19 35 34987 128446 50441656
Dental caries 21.24 10.19 30 34992 9837 50560265
Mastectomy 21.15 10.19 13 35009 1456 50568646
Drug ineffective for unapproved indication 21.13 10.19 46 34976 21235 50548867
Oligomenorrhoea 21.01 10.19 10 35012 672 50569430
Diverticulum 20.99 10.19 31 34991 10583 50559519
Blister 20.95 10.19 17 35005 85401 50484701
C-reactive protein increased 20.76 10.19 10 35012 66464 50503638
Osteoarthritis 20.53 10.19 98 34924 68508 50501594
Osteonecrosis 20.48 10.19 47 34975 22470 50547632
Coma 20.29 10.19 7 35015 56872 50513230
Abortion missed 20.22 10.19 13 35009 1575 50568527
Cardiac failure 20.11 10.19 14 35008 76026 50494076
Resorption bone increased 20.01 10.19 11 35011 1000 50569102
Endometrial cancer stage I 19.74 10.19 7 35015 220 50569882
Rash 19.57 10.19 201 34821 437270 50132832
Adnexa uteri pain 19.44 10.19 8 35014 379 50569723
Product use issue 19.41 10.19 47 34975 149428 50420674
Cervicitis 19.33 10.19 8 35014 385 50569717
Uterine pain 19.21 10.19 7 35015 238 50569864
Injection site reaction 19.19 10.19 77 34945 49955 50520147
Urine leukocyte esterase 19.16 10.19 6 35016 127 50569975
Menometrorrhagia 18.93 10.19 10 35012 839 50569263
Decidual cast 18.83 10.19 3 35019 0 50570102
Renal failure 18.69 10.19 28 34994 106605 50463497
Intentional overdose 18.63 10.19 10 35012 62494 50507608
Fracture nonunion 18.56 10.19 14 35008 2190 50567912
Emotional disorder 18.46 10.19 31 34991 11805 50558297
Vaginal odour 18.40 10.19 8 35014 435 50569667
Endometrial atrophy 18.23 10.19 5 35017 65 50570037
Device mechanical issue 18.16 10.19 5 35017 66 50570036
Intentional product use issue 18.02 10.19 16 35006 76902 50493200
Helicobacter infection 17.93 10.19 6 35016 49696 50520406
Weight increased 17.90 10.19 216 34806 201675 50368427
Thyrotoxic periodic paralysis 17.79 10.19 4 35018 21 50570081
Injection site discolouration 17.74 10.19 23 34999 6951 50563151
Renal impairment 17.41 10.19 16 35006 75645 50494457
Drug abuse 17.22 10.19 10 35012 59836 50510266
Medical device discomfort 17.19 10.19 12 35010 1665 50568437
Internal injury 17.15 10.19 7 35015 325 50569777
Disease progression 16.97 10.19 25 34997 95841 50474261
Angina unstable 16.88 10.19 22 35000 6684 50563418
Pancytopenia 16.83 10.19 20 35002 84010 50486092
General physical health deterioration 16.80 10.19 47 34975 142387 50427715
Skin laceration 16.78 10.19 39 34983 18803 50551299
Placenta accreta 16.73 10.19 6 35016 195 50569907
Postmortem blood drug level abnormal 16.64 10.19 7 35015 351 50569751
Benign breast neoplasm 16.45 10.19 10 35012 1098 50569004
Stress fracture 16.45 10.19 22 35000 6853 50563249
Osteomyelitis 16.44 10.19 43 34979 22310 50547792
Withdrawal bleed 16.34 10.19 4 35018 32 50570070
Delayed puberty 16.32 10.19 5 35017 98 50570004
Vulvovaginal dryness 16.32 10.19 13 35009 2204 50567898
Muscle fatigue 16.20 10.19 13 35009 2226 50567876
Breast reconstruction 15.94 10.19 6 35016 224 50569878
Arthropathy 15.88 10.19 56 34966 157850 50412252
Febrile neutropenia 15.84 10.19 27 34995 97640 50472462
Cerebral palsy 15.83 10.19 5 35017 109 50569993
Cardiac arrest 15.62 10.19 21 35001 83630 50486472
Blood oestrogen decreased 15.62 10.19 6 35016 237 50569865
Device difficult to use 15.56 10.19 26 34996 9860 50560242
Neurofibroma 15.54 10.19 3 35019 6 50570096
Libido decreased 15.53 10.19 13 35009 2363 50567739
Folliculitis 15.49 10.19 4 35018 39221 50530881
Deformity 15.43 10.19 23 34999 7917 50562185
Diabetes mellitus 15.37 10.19 71 34951 48962 50521140
Pregnancy with implant contraceptive 15.18 10.19 12 35010 2011 50568091
Road traffic accident 15.09 10.19 44 34978 24308 50545794
Modified radical mastectomy 14.94 10.19 3 35019 8 50570094
Adenomyosis 14.90 10.19 7 35015 457 50569645
Endometrial hypertrophy 14.83 10.19 6 35016 272 50569830
Meniscus injury 14.82 10.19 20 35002 6282 50563820
Femur fracture 14.64 10.19 58 34964 37406 50532696
Ill-defined disorder 14.53 10.19 10 35012 54644 50515458
Breast necrosis 14.48 10.19 5 35017 145 50569957
Uterine injury 14.45 10.19 4 35018 54 50570048
Livedo reticularis 14.43 10.19 12 35010 2160 50567942
Thrombocytopenia 14.42 10.19 43 34979 127630 50442472
Bradycardia 14.38 10.19 14 35008 64412 50505690
Lumbar spinal stenosis 14.34 10.19 16 35006 4138 50565964
Complication of device removal 14.31 10.19 16 35006 4148 50565954
Mucosal inflammation 14.21 10.19 5 35017 40137 50529965
Radiotherapy 14.20 10.19 6 35016 304 50569798
Oestrogen deficiency 14.19 10.19 5 35017 154 50569948
Immunoglobulin G4 related disease 14.18 10.19 4 35018 58 50570044
Foot fracture 14.12 10.19 38 34984 20053 50550049
Respiratory failure 14.07 10.19 26 34996 91155 50478947
Galactorrhoea 14.00 10.19 15 35007 3708 50566394
Toothache 13.99 10.19 34 34988 16860 50553242
Large intestine polyp 13.91 10.19 21 35001 7311 50562791
Seborrhoeic keratosis 13.87 10.19 11 35011 1852 50568250
Inappropriate schedule of product administration 13.76 10.19 91 34931 71740 50498362
Muscle spasms 13.71 10.19 140 34882 125413 50444689
Injection site abscess sterile 13.64 10.19 3 35019 14 50570088
Anhedonia 13.61 10.19 24 34998 9500 50560602
Device breakage 13.57 10.19 24 34998 9523 50560579
Knee arthroplasty 13.51 10.19 4 35018 35842 50534260
Breast pain 13.45 10.19 21 35001 7523 50562579
Dehydration 13.44 10.19 57 34965 152392 50417710
Post procedural cellulitis 13.43 10.19 4 35018 71 50570031
Mitral valve incompetence 13.25 10.19 34 34988 17437 50552665
Hypotension 13.22 10.19 102 34920 235367 50334735
Product administered at inappropriate site 13.21 10.19 12 35010 2431 50567671
Loss of libido 13.12 10.19 9 35013 1214 50568888
Delirium 13.11 10.19 5 35017 38187 50531915
Injection site induration 13.10 10.19 22 35000 8375 50561727
Breast fibrosis 13.00 10.19 3 35019 18 50570084
Menopausal symptoms 12.98 10.19 11 35011 2032 50568070
Crystalluria 12.89 10.19 6 35016 383 50569719
Vaginal discharge 12.89 10.19 17 35005 5223 50564879
Cartilage injury 12.89 10.19 10 35012 1632 50568470
Cardio-respiratory arrest 12.88 10.19 11 35011 53881 50516221
Oral infection 12.78 10.19 15 35007 4099 50566003
Breast cancer stage II 12.75 10.19 10 35012 1657 50568445
Hospitalisation 12.74 10.19 17 35005 67920 50502182
Complication associated with device 12.68 10.19 30 34992 14625 50555477
Hypothyroidism 12.67 10.19 52 34970 34073 50536029
Anaemia postoperative 12.67 10.19 11 35011 2100 50568002
Gingivitis 12.61 10.19 20 35002 7264 50562838
Product packaging issue 12.52 10.19 8 35014 959 50569143
Mitral valve prolapse 12.50 10.19 11 35011 2139 50567963
Post procedural discomfort 12.42 10.19 8 35014 972 50569130
Breast disorder female 12.42 10.19 4 35018 93 50570009
Drug interaction 12.40 10.19 84 34938 199537 50370565
Uterine cervix stenosis 12.40 10.19 5 35017 225 50569877
Nocturia 12.37 10.19 19 35003 6711 50563391
Uterine disorder 12.36 10.19 12 35010 2643 50567459
Hirsutism 12.25 10.19 8 35014 995 50569107
Intentional device misuse 12.14 10.19 7 35015 697 50569405
Thyroid disorder 12.13 10.19 27 34995 12650 50557452
Anticonvulsant drug level increased 12.12 10.19 9 35013 1375 50568727
Burns second degree 12.06 10.19 7 35015 706 50569396
Platelet count decreased 12.05 10.19 33 34989 100693 50469409
Pregnancy test urine positive 12.04 10.19 3 35019 26 50570076
Drug exposure before pregnancy 11.92 10.19 7 35015 722 50569380
Hyperkeratosis 11.88 10.19 16 35006 5019 50565083
Malignant neoplasm progression 11.83 10.19 18 35004 68106 50501996
Hepatic function abnormal 11.69 10.19 4 35018 32677 50537425
Alopecia 11.59 10.19 111 34911 244936 50325166
Uterine spasm 11.58 10.19 6 35016 484 50569618
HIV test positive 11.57 10.19 3 35019 31 50570071
Medical device pain 11.55 10.19 9 35013 1478 50568624
Cholecystectomy 11.48 10.19 22 35000 9281 50560821
Insomnia 11.36 10.19 177 34845 174688 50395414
Chlamydial infection 11.35 10.19 5 35017 281 50569821
Cervicobrachial syndrome 11.31 10.19 7 35015 794 50569308
Mobility decreased 11.30 10.19 24 34998 79924 50490178
Adenoma benign 11.28 10.19 7 35015 797 50569305
Gastrointestinal disorder 11.26 10.19 31 34991 94425 50475677
Endometriosis 11.25 10.19 14 35008 4061 50566041
Pregnancy with contraceptive device 11.24 10.19 14 35008 4065 50566037
Unwanted pregnancy 11.24 10.19 3 35019 35 50570067
Blood cholesterol increased 11.21 10.19 71 34951 55144 50514958
Oxygen saturation decreased 11.20 10.19 21 35001 73227 50496875
Intramedullary rod insertion 11.16 10.19 10 35012 1990 50568112
Injection site cellulitis 11.10 10.19 8 35014 1167 50568935
Gallbladder disorder 11.10 10.19 31 34991 16711 50553391
Chest pain 11.10 10.19 178 34844 176704 50393398
Protein urine present 11.06 10.19 16 35006 5361 50564741
Myocardial infarction 11.06 10.19 102 34920 88925 50481177
Atrophic vulvovaginitis 10.99 10.19 9 35013 1587 50568515
Lipoatrophy 10.91 10.19 5 35017 308 50569794
Tic 10.85 10.19 8 35014 1209 50568893
Acne 10.82 10.19 34 34988 19561 50550541
Hypoaesthesia 10.77 10.19 135 34887 127122 50442980
Feelings of worthlessness 10.72 10.19 5 35017 321 50569781
Fear 10.71 10.19 28 34994 14521 50555581
Anaphylactic reaction 10.66 10.19 69 34953 53986 50516116
Nasopharyngitis 10.63 10.19 84 34938 192843 50377259
Circumstance or information capable of leading to medication error 10.53 10.19 12 35010 3176 50566926
Bone loss 10.47 10.19 11 35011 2661 50567441
Haemorrhoids 10.46 10.19 33 34989 19020 50551082
Ventricular hypertrophy 10.45 10.19 12 35010 3203 50566899
Injection site discomfort 10.43 10.19 13 35009 3777 50566325
Device defective 10.41 10.19 8 35014 1287 50568815
Fat necrosis 10.39 10.19 6 35016 599 50569503
Nitrite urine present 10.37 10.19 7 35015 920 50569182
Marital problem 10.29 10.19 4 35018 163 50569939
Cough 10.29 10.19 112 34910 241152 50328950
Lumbar radiculopathy 10.28 10.19 9 35013 1737 50568365
Plagiocephaly 10.19 10.19 3 35019 51 50570051

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Head titubation 64.80 35.17 10 569 281 29573667
Sedation complication 56.04 35.17 11 568 1271 29572677
Cogwheel rigidity 50.30 35.17 10 569 1233 29572715
Anticholinergic syndrome 41.07 35.17 8 571 886 29573062
Extrapyramidal disorder 40.86 35.17 13 566 10818 29563130
Porphyria non-acute 39.63 35.17 7 572 454 29573494
Exposure during pregnancy 39.55 35.17 12 567 8542 29565406
Lupus nephritis 36.78 35.17 6 573 241 29573707
Unmasking of previously unidentified disease 36.48 35.17 7 572 716 29573232

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Unintended pregnancy 1117.53 11.43 260 26762 2874 64468836
Pregnancy with injectable contraceptive 522.20 11.43 81 26941 32 64471678
Intermenstrual bleeding 267.33 11.43 95 26927 5030 64466680
Amenorrhoea 186.06 11.43 78 26944 6461 64465249
Vaginal haemorrhage 185.19 11.43 110 26912 19234 64452476
Heavy menstrual bleeding 182.95 11.43 93 26929 11984 64459726
Injection site abscess 159.73 11.43 47 26975 1351 64470359
Depression 148.23 11.43 271 26751 183020 64288690
Osteopenia 145.18 11.43 87 26935 15453 64456257
Drug dose omission by device 111.12 11.43 45 26977 3412 64468298
Oestrogen receptor assay positive 108.65 11.43 25 26997 261 64471449
Uterine perforation 106.55 11.43 51 26971 5769 64465941
Injection site atrophy 101.78 11.43 25 26997 352 64471358
Breast cancer in situ 93.88 11.43 28 26994 844 64470866
Injury 91.43 11.43 115 26907 55877 64415833
Fibrocystic breast disease 90.17 11.43 25 26997 577 64471133
Menstruation irregular 81.60 11.43 39 26983 4396 64467314
Pelvic pain 81.50 11.43 53 26969 10857 64460853
Death 81.40 11.43 51 26971 482654 63989056
Progesterone receptor assay positive 80.93 11.43 19 27003 218 64471492
Breast cancer female 79.33 11.43 40 26982 5063 64466647
Breast cancer 78.93 11.43 78 26944 29070 64442640
Abortion spontaneous 78.93 11.43 73 26949 25070 64446640
Uterine leiomyoma 77.41 11.43 40 26982 5329 64466381
Device issue 63.92 11.43 62 26960 22586 64449124
Emotional distress 63.62 11.43 77 26945 35961 64435749
Anxiety 61.77 11.43 206 26816 202443 64269267
Acute kidney injury 61.08 11.43 59 26963 449181 64022529
Uterine haemorrhage 60.99 11.43 27 26995 2552 64469158
Pulmonary embolism 59.85 11.43 165 26857 146191 64325519
Genital haemorrhage 59.71 11.43 34 26988 5488 64466222
Postmenopausal haemorrhage 57.81 11.43 22 27000 1413 64470297
Clear cell renal cell carcinoma 55.38 11.43 24 26998 2155 64469555
Device dislocation 54.25 11.43 55 26967 21123 64450587
Needle issue 50.30 11.43 37 26985 9235 64462475
Pyrexia 50.21 11.43 99 26923 558545 63913165
Renal mass 50.06 11.43 24 26998 2723 64468987
Dysmenorrhoea 46.07 11.43 22 27000 2475 64469235
Breast calcifications 46.00 11.43 16 27006 794 64470916
Osteoporosis 45.59 11.43 71 26951 42009 64429701
Uterine polyp 45.22 11.43 18 27004 1304 64470406
Toxicity to various agents 43.54 11.43 53 26969 363460 64108250
Injection site necrosis 41.73 11.43 17 27005 1308 64470402
Incorrect dose administered by device 41.03 11.43 24 26998 4073 64467637
Neutropenia 40.74 11.43 25 26997 239599 64232111
Pneumonia 40.73 11.43 111 26911 559465 63912245
Sepsis 40.62 11.43 23 26999 230318 64241392
Gastrooesophageal reflux disease 38.28 11.43 98 26924 83045 64388665
Device leakage 38.25 11.43 30 26992 8236 64463474
Hot flush 38.07 11.43 69 26953 46166 64425544
Cholecystitis chronic 37.24 11.43 31 26991 9256 64462454
Menstrual disorder 37.14 11.43 21 27001 3344 64468366
Osteoarthritis 35.99 11.43 81 26941 63255 64408455
Procedural pain 35.63 11.43 38 26984 15470 64456240
Breast disorder 34.65 11.43 16 27006 1668 64470042
Mammogram abnormal 34.36 11.43 11 27011 421 64471289
Contraindicated product administered 34.07 11.43 3 27019 107826 64363884
Injection site panniculitis 33.89 11.43 5 27017 0 64471710
Dyspareunia 33.83 11.43 16 27006 1761 64469949
Mood swings 33.59 11.43 39 26983 17429 64454281
Migraine 33.23 11.43 78 26944 62599 64409111
Exostosis of jaw 33.15 11.43 14 27008 1180 64470530
Low turnover osteopathy 33.03 11.43 16 27006 1857 64469853
Endometrial cancer 32.73 11.43 16 27006 1894 64469816
Endometrial hyperplasia 32.70 11.43 11 27011 493 64471217
Scoliosis 32.38 11.43 24 26998 6058 64465652
Stress urinary incontinence 32.31 11.43 15 27007 1583 64470127
Drug abuse 32.01 11.43 8 27014 132366 64339344
Breast tenderness 31.67 11.43 16 27006 2033 64469677
Abnormal uterine bleeding 30.78 11.43 12 27010 823 64470887
Abdominal pain lower 30.55 11.43 46 26976 26423 64445287
Off label use 30.51 11.43 149 26873 632657 63839053
Embedded device 29.90 11.43 17 27005 2735 64468975
Pregnancy test positive 29.61 11.43 7 27015 83 64471627
Hyperlipidaemia 29.52 11.43 42 26980 22934 64448776
Injection site pain 29.35 11.43 108 26914 111300 64360410
Scar 29.33 11.43 32 26990 13366 64458344
Porphyria non-acute 28.85 11.43 11 27011 710 64471000
Treatment failure 28.36 11.43 7 27015 116809 64354901
Exposure during pregnancy 28.25 11.43 84 26938 77591 64394119
Eosinopenia 27.85 11.43 6 27016 45 64471665
Syringe issue 27.62 11.43 19 27003 4267 64467443
Spinal osteoarthritis 27.54 11.43 32 26990 14309 64457401
Cerebral venous sinus thrombosis 27.26 11.43 14 27008 1841 64469869
Device failure 27.08 11.43 21 27001 5671 64466039
Osteonecrosis 26.98 11.43 45 26977 28184 64443526
Renal failure 26.87 11.43 22 27000 181666 64290044
Cerebrovascular accident 26.44 11.43 121 26901 137462 64334248
Infertility female 26.18 11.43 9 27013 431 64471279
Vulvovaginal dryness 26.16 11.43 13 27009 1595 64470115
Deep vein thrombosis 26.07 11.43 100 26922 105082 64366628
Endometrial cancer stage I 25.61 11.43 7 27015 153 64471557
Completed suicide 25.50 11.43 34 26988 224380 64247330
Rheumatoid arthritis 25.42 11.43 19 27003 164275 64307435
Benign breast neoplasm 24.84 11.43 10 27012 746 64470964
Intervertebral disc degeneration 24.74 11.43 29 26993 13091 64458619
Complication of device removal 24.65 11.43 16 27006 3264 64468446
Breast reconstruction 24.46 11.43 6 27016 84 64471626
Weight increased 24.42 11.43 163 26859 213185 64258525
Dental caries 24.00 11.43 26 26996 10774 64460936
Product administration error 23.71 11.43 42 26980 27601 64444109
Medical device discomfort 23.66 11.43 12 27010 1537 64470173
Urticaria 23.61 11.43 123 26899 147194 64324516
Cardiac arrest 23.60 11.43 18 27004 154046 64317664
Drug interaction 23.28 11.43 76 26946 362007 64109703
Deformity 23.16 11.43 20 27002 6277 64465433
Hyponatraemia 23.15 11.43 17 27005 148322 64323388
Diarrhoea 23.09 11.43 193 26829 722511 63749199
Febrile neutropenia 22.81 11.43 27 26995 187630 64284080
Toothache 22.55 11.43 32 26990 17427 64454283
Injection site reaction 22.51 11.43 56 26966 46608 64425102
Injection site inflammation 22.48 11.43 15 27007 3206 64468504
Cardiac failure 22.22 11.43 14 27008 132359 64339351
Respiratory failure 22.04 11.43 21 27001 161162 64310548
Bradycardia 22.01 11.43 11 27011 118208 64353502
Blood cholesterol increased 21.99 11.43 58 26964 50008 64421702
Cervical dysplasia 21.38 11.43 12 27010 1884 64469826
Adnexa uteri pain 20.95 11.43 7 27015 307 64471403
Urine leukocyte esterase 20.85 11.43 6 27016 159 64471551
Injection site indentation 20.82 11.43 6 27016 160 64471550
Device difficult to use 20.75 11.43 23 26999 9775 64461935
Poor quality device used 20.74 11.43 12 27010 1995 64469715
Ectopic pregnancy 20.68 11.43 11 27011 1553 64470157
Resorption bone increased 20.66 11.43 10 27012 1158 64470552
Thrombocytopenia 20.61 11.43 39 26983 223762 64247948
Renal impairment 20.39 11.43 16 27006 135001 64336709
Decidual cast 20.34 11.43 3 27019 0 64471710
Pregnancy with contraceptive device 20.29 11.43 14 27008 3160 64468550
Insomnia 20.19 11.43 147 26875 197689 64274021
Oligomenorrhoea 20.14 11.43 8 27014 576 64471134
Internal injury 19.85 11.43 7 27015 362 64471348
Breast mass 19.80 11.43 17 27005 5293 64466417
Vaginal discharge 19.57 11.43 15 27007 3982 64467728
Emotional disorder 19.15 11.43 25 26997 12582 64459128
Product quality issue 19.07 11.43 40 26982 29759 64441951
Stress fracture 18.96 11.43 17 27005 5607 64466103
Gallbladder disorder 18.81 11.43 29 26993 17001 64454709
Osteomyelitis 18.80 11.43 38 26984 27549 64444161
Confusional state 18.79 11.43 52 26970 261092 64210618
Fracture nonunion 18.52 11.43 10 27012 1456 64470254
Breast cyst 18.20 11.43 9 27013 1092 64470618
Prolactin-producing pituitary tumour 18.01 11.43 5 27017 116 64471594
Adenomyosis 17.92 11.43 6 27016 265 64471445
Modified radical mastectomy 17.79 11.43 3 27019 4 64471706
Menopausal symptoms 17.76 11.43 10 27012 1580 64470130
Hepatic enzyme increased 17.68 11.43 17 27005 129926 64341784
Abortion missed 17.67 11.43 9 27013 1163 64470547
Disease progression 17.63 11.43 20 27002 141660 64330050
Maternal drugs affecting foetus 17.58 11.43 10 27012 1610 64470100
Blood oestrogen decreased 17.58 11.43 5 27017 127 64471583
Lumbar spinal stenosis 17.57 11.43 15 27007 4635 64467075
Breast hyperplasia 17.47 11.43 5 27017 130 64471580
C-reactive protein increased 17.41 11.43 9 27013 94900 64376810
Intentional overdose 17.30 11.43 8 27014 89936 64381774
Head titubation 17.30 11.43 8 27014 837 64470873
Endometrial atrophy 17.28 11.43 4 27018 43 64471667
Oral infection 17.22 11.43 15 27007 4762 64466948
Bone density decreased 17.13 11.43 21 27001 9931 64461779
Diabetes mellitus 17.13 11.43 64 26958 66410 64405300
Skin laceration 17.08 11.43 34 26988 24383 64447327
Pancytopenia 17.01 11.43 21 27001 143288 64328422
Delayed puberty 16.82 11.43 5 27017 149 64471561
Vaginal odour 16.82 11.43 6 27016 321 64471389
Post procedural discomfort 16.79 11.43 8 27014 895 64470815
Uterine injury 16.72 11.43 4 27018 50 64471660
Cartilage injury 16.54 11.43 9 27013 1330 64470380
Cerebral palsy 16.54 11.43 5 27017 158 64471552
Coma 16.53 11.43 8 27014 87607 64384103
Hypotension 16.46 11.43 93 26929 380881 64090829
Medical device pain 16.43 11.43 9 27013 1347 64470363
Muscle fatigue 16.10 11.43 12 27010 3053 64468657
Foot fracture 16.10 11.43 28 26994 18129 64453581
Postmortem blood drug level abnormal 16.03 11.43 7 27015 640 64471070
Uterine pain 16.02 11.43 5 27017 176 64471534
Therapeutic product effect incomplete 15.96 11.43 12 27010 103470 64368240
Biopsy breast abnormal 15.94 11.43 3 27019 10 64471700
Device breakage 15.92 11.43 19 27003 8736 64462974
Lower respiratory tract infection 15.88 11.43 10 27012 94604 64377106
Breast cancer stage II 15.86 11.43 9 27013 1443 64470267
Uterine cervix stenosis 15.78 11.43 5 27017 185 64471525
Intentional device misuse 15.78 11.43 7 27015 665 64471045
Placenta accreta 15.76 11.43 5 27017 186 64471524
Cardio-respiratory arrest 15.71 11.43 11 27011 98382 64373328
Galactorrhoea 15.58 11.43 12 27010 3207 64468503
Post procedural cellulitis 15.47 11.43 4 27018 70 64471640
Suicidal ideation 15.46 11.43 62 26960 66480 64405230
Femur fracture 15.46 11.43 40 26982 34095 64437615
Diverticulum 15.32 11.43 23 26999 13175 64458535
Hyperkalaemia 15.25 11.43 12 27010 101117 64370593
Breast necrosis 15.16 11.43 4 27018 76 64471634
Oestrogen deficiency 15.02 11.43 4 27018 79 64471631
Platelet count decreased 14.76 11.43 30 26992 167681 64304029
Throat tightness 14.72 11.43 31 26991 23129 64448581
Coronary artery disease 14.59 11.43 57 26965 60376 64411334
Gingivitis 14.56 11.43 17 27005 7642 64464068
Meniscus injury 14.51 11.43 15 27007 5892 64465818
Breast cancer stage I 14.43 11.43 9 27013 1715 64469995
Drug exposure before pregnancy 14.40 11.43 6 27016 489 64471221
Lumbar radiculopathy 14.27 11.43 9 27013 1748 64469962
Thyrotoxic periodic paralysis 14.24 11.43 4 27018 97 64471613
Interstitial lung disease 14.23 11.43 12 27010 97720 64373990
Septic shock 14.10 11.43 14 27008 105423 64366287
Uterine disorder 13.99 11.43 9 27013 1808 64469902
Cholecystectomy 13.91 11.43 17 27005 8015 64463695
Atrial fibrillation 13.90 11.43 32 26990 171057 64300653
Premature menopause 13.85 11.43 6 27016 538 64471172
Unwanted pregnancy 13.64 11.43 3 27019 25 64471685
Withdrawal bleed 13.64 11.43 3 27019 25 64471685
Therapeutic product effect decreased 13.58 11.43 17 27005 115334 64356376
Burns second degree 13.54 11.43 7 27015 933 64470777
Intentional product use issue 13.53 11.43 12 27010 95352 64376358
Hepatic function abnormal 13.53 11.43 5 27017 64308 64407402
Mitral valve prolapse 13.51 11.43 9 27013 1918 64469792
Incorrect route of product administration 13.45 11.43 30 26992 23268 64448442
Immunoglobulin G4 related disease 13.43 11.43 4 27018 120 64471590
Joint swelling 13.28 11.43 46 26976 215336 64256374
Complication of pregnancy 13.24 11.43 5 27017 314 64471396
Hypoglycaemia 13.14 11.43 11 27011 89881 64381829
Device expulsion 13.10 11.43 28 26994 21108 64450602
Hypothyroidism 13.07 11.43 42 26980 40415 64431295
Stomatitis 13.07 11.43 16 27006 109589 64362121
General physical health deterioration 13.05 11.43 43 26979 204382 64267328
Complication associated with device 13.04 11.43 23 26999 15057 64456653
Thyroid disorder 13.04 11.43 20 27002 11672 64460038
Hyperkeratosis 12.98 11.43 15 27007 6666 64465044
Mucosal inflammation 12.94 11.43 5 27017 62579 64409131
Malignant neoplasm progression 12.91 11.43 17 27005 112854 64358856
Progesterone decreased 12.73 11.43 3 27019 35 64471675
Nitrite urine present 12.68 11.43 7 27015 1065 64470645
Spondylolisthesis 12.62 11.43 10 27012 2784 64468926
Wrong technique in device usage process 12.35 11.43 10 27012 2872 64468838
Hypoaesthesia 12.30 11.43 100 26922 139008 64332702
Uterine spasm 12.26 11.43 5 27017 386 64471324
Carpal tunnel syndrome 12.24 11.43 23 26999 15805 64455905
Endometrial hypertrophy 12.21 11.43 4 27018 165 64471545
Livedo reticularis 12.12 11.43 11 27011 3686 64468024
Lip swelling 12.06 11.43 35 26987 31872 64439838
Menopause 12.03 11.43 8 27014 1700 64470010
Atrophic vulvovaginitis 11.93 11.43 7 27015 1194 64470516
Productive cough 11.93 11.43 8 27014 73195 64398515
Bacterial test 11.90 11.43 7 27015 1200 64470510
Road traffic accident 11.89 11.43 34 26988 30711 64440999
Multiple organ dysfunction syndrome 11.88 11.43 15 27007 101398 64370312
Anticonvulsant drug level increased 11.81 11.43 9 27013 2368 64469342
Morton's neuralgia 11.74 11.43 3 27019 50 64471660
Muscle spasms 11.74 11.43 100 26922 140923 64330787
Infection 11.72 11.43 39 26983 184841 64286869
Fear 11.68 11.43 26 26996 20145 64451565
Mitral valve incompetence 11.64 11.43 30 26992 25508 64446202
Sneezing 11.60 11.43 22 27000 15229 64456481
Cervicitis 11.59 11.43 4 27018 194 64471516
Patellofemoral pain syndrome 11.55 11.43 5 27017 448 64471262
Sciatic nerve injury 11.46 11.43 5 27017 456 64471254
Cervix carcinoma 11.46 11.43 8 27014 1840 64469870

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03AA08 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA17 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AC06 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens
ATC G03DA02 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS
Pregnen (4) derivatives
ATC G03FA12 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS AND ESTROGENS IN COMBINATION
Progestogens and estrogens, fixed combinations
ATC G03FB06 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS AND ESTROGENS IN COMBINATION
Progestogens and estrogens, sequential preparations
ATC L02AB02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ENDOCRINE THERAPY
HORMONES AND RELATED AGENTS
Progestogens
FDA CS M0447349 Progesterone Congeners
FDA EPC N0000175602 Progestin
MeSH PA D003270 Contraceptive Agents
MeSH PA D003271 Contraceptive Agents, Female
MeSH PA D000080066 Contraceptive Agents, Hormonal
MeSH PA D003278 Contraceptives, Oral, Hormonal
MeSH PA D003280 Contraceptives, Oral, Synthetic
MeSH PA D012102 Reproductive Control Agents
CHEBI has role CHEBI:49323 contraceptive drugs
CHEBI has role CHEBI:49326 synthetic oral contraceptives
CHEBI has role CHEBI:59826 progestins
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:35222 inhibitor
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:49324 female contraceptive drugs
CHEBI has role CHEBI:50113 androgene
CHEBI has role CHEBI:60809 adjuvants
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D003272 Contraceptive Agents, Male

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Contraception indication 13197004
Dysfunctional uterine bleeding indication 19155002
Atrophic vaginitis indication 52441000
Secondary physiologic amenorrhea indication 86030004
Secondary malignant neoplasm of kidney indication 94360002
Postmenopausal osteoporosis indication 102447009
Endometriosis indication 129103003
Menopausal flushing indication 198436008
Endometrial carcinoma indication 254878006 DOID:2871
Endometrial Hyperplasia Prevention indication
Polycystic ovaries off-label use 69878008
Precocious puberty off-label use 400179000
Endogenous Estrogen Production Test off-label use
Hyperlipoproteinemia contraindication 3744001 DOID:1168
Hypocalcemia contraindication 5291005
Alcoholism contraindication 7200002
Weight gain finding contraindication 8943002
Hypercholesterolemia contraindication 13644009
Myocardial infarction contraindication 22298006 DOID:5844
Fibroadenosis of breast contraindication 23260002 DOID:10352
Depressive disorder contraindication 35489007
Chloasma contraindication 36209000
Migraine contraindication 37796009 DOID:6364
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Body fluid retention contraindication 43498006
Thrombosis of retinal vein contraindication 46085004
Humoral hypercalcemia of malignancy contraindication 47709007
Dementia contraindication 52448006
Hepatic porphyria contraindication 55056006 DOID:3133
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Hyperlipidemia contraindication 55822004 DOID:1168
Anorexia nervosa contraindication 56882008 DOID:8689
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Thrombophlebitis contraindication 64156001 DOID:3875
Osteoporosis contraindication 64859006 DOID:11476
Intermenstrual bleeding - irregular contraindication 64996003
Diabetes mellitus contraindication 73211009 DOID:9351
Epilepsy contraindication 84757009 DOID:1826
Breast lump contraindication 89164003
Kidney disease contraindication 90708001 DOID:557
Uterine leiomyoma contraindication 95315005 DOID:13223
Deep venous thrombosis contraindication 128053003
Mammography abnormal contraindication 168750009
Asthma contraindication 195967001 DOID:2841
Cerebrovascular accident contraindication 230690007
Pulmonary thromboembolism contraindication 233935004
Thrombophilia contraindication 234467004 DOID:2452
Disease of liver contraindication 235856003 DOID:409
Chorea contraindication 271700006
Pregnancy, function contraindication 289908002
Hypertriglyceridemia contraindication 302870006
Osteopenia contraindication 312894000
Functional visual loss contraindication 313165001
Malignant tumor of ovary contraindication 363443007 DOID:2394
Thromboembolic disorder contraindication 371039008
Cardiovascular event risk contraindication 395112001
Disorder of coronary artery contraindication 414024009
Obesity contraindication 414916001 DOID:9970
Estrogen receptor positive tumor contraindication 416053008
Family history of malignant neoplasm of breast contraindication 429740004
Hypertensive urgency contraindication 443482000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Progesterone receptor Nuclear hormone receptor AGONIST EC50 9.59 WOMBAT-PK CHEMBL
Glucocorticoid receptor Nuclear hormone receptor Ki 7.88 CHEMBL
Mineralocorticoid receptor Nuclear hormone receptor IC50 5.92 CHEMBL
Androgen receptor Nuclear hormone receptor EC50 8.20 WOMBAT-PK
Aldo-keto reductase family 1 member C1 Enzyme IC50 5.74 CHEMBL
Aldo-keto reductase family 1 member C2 Enzyme IC50 5.39 CHEMBL
Aldo-keto reductase family 1 member C3 Enzyme IC50 6.52 CHEMBL
Cytochrome P450 2C19 Enzyme IC50 5.70 DRUG MATRIX
Sex hormone-binding globulin Secreted Kd 6.20 CHEMBL
Histamine H2 receptor GPCR Ki 4.56 DRUG MATRIX
Estrogen receptor Nuclear hormone receptor IC50 6.03 CHEMBL
Androgen receptor Transcription factor IC50 7.45 CHEMBL
Progesterone receptor Transcription factor Ki 7.03 DRUG MATRIX
Androgen receptor Transcription factor EC50 8.21 CHEMBL

External reference:

IDSource
4019810 VUID
N0000147899 NUI
D00951 KEGG_DRUG
4017828 VANDF
4019810 VANDF
C0025147 UMLSCUI
CHEBI:6715 CHEBI
CHEMBL717 ChEMBL_ID
D008525 MESH_DESCRIPTOR_UI
10631 PUBCHEM_CID
2879 IUPHAR_LIGAND_ID
853 INN_ID
HSU1C9YRES UNII
DB00603 DRUGBANK_ID
1000112 RXNORM
5032 MMSL
7121 MMSL
d00284 MMSL
001295 NDDF
004938 NDDF
126112002 SNOMEDCT_US
126113007 SNOMEDCT_US
36621009 SNOMEDCT_US
D017258 MESH_DESCRIPTOR_UI
520-85-4 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-0050 TABLET 10 mg ORAL NDA 25 sections
Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-0051 TABLET 10 mg ORAL NDA 25 sections
Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-0064 TABLET 2.50 mg ORAL NDA 25 sections
Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-0065 TABLET 2.50 mg ORAL NDA 25 sections
Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-0286 TABLET 5 mg ORAL NDA 25 sections
Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-0287 TABLET 5 mg ORAL NDA 25 sections
Depo-Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-0746 INJECTION, SUSPENSION 150 mg INTRAMUSCULAR NDA 29 sections
Depo-SubQ Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-4709 INJECTION, SUSPENSION 104 mg SUBCUTANEOUS NDA 30 sections
Depo-Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-7376 INJECTION, SUSPENSION 150 mg INTRAMUSCULAR NDA 29 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1105 TABLET, SUGAR COATED 1.50 mg ORAL NDA 30 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1106 TABLET, SUGAR COATED 1.50 mg ORAL NDA 30 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1107 TABLET, SUGAR COATED 2.50 mg ORAL NDA 30 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1108 TABLET, SUGAR COATED 5 mg ORAL NDA 30 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0548-5400 INJECTION, SUSPENSION, EXTENDED RELEASE 150 mg INTRAMUSCULAR ANDA 29 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0548-5410 INJECTION, SUSPENSION, EXTENDED RELEASE 150 mg INTRAMUSCULAR ANDA 29 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0548-5701 INJECTION, SUSPENSION, EXTENDED RELEASE 150 mg INTRAMUSCULAR ANDA 29 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0548-5711 INJECTION, SUSPENSION, EXTENDED RELEASE 150 mg INTRAMUSCULAR ANDA 29 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0555-0779 TABLET 10 mg ORAL ANDA 24 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0555-0872 TABLET 2.50 mg ORAL ANDA 24 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0555-0873 TABLET 5 mg ORAL ANDA 24 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0703-6801 INJECTION, SUSPENSION 150 mg INTRAMUSCULAR ANDA 29 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 10544-001 TABLET 5 mg ORAL ANDA 24 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 10544-062 TABLET 10 mg ORAL ANDA 24 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 16714-028 INJECTION, SUSPENSION 150 mg INTRAMUSCULAR ANDA 28 sections
MEDROXYPROGESTERONE ACETATE Human Prescription Drug Label 1 16714-981 INJECTION, SUSPENSION 150 mg INTRAMUSCULAR ANDA 27 sections
MEDROXYPROGESTERONE ACETATE Human Prescription Drug Label 1 16714-999 INJECTION, SUSPENSION 150 mg INTRAMUSCULAR ANDA 27 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 21695-896 TABLET 10 mg ORAL ANDA 23 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 33261-534 TABLET 10 mg ORAL ANDA 24 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 33261-609 TABLET 2.50 mg ORAL ANDA 24 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 33261-740 TABLET 5 mg ORAL ANDA 24 sections