medroxyprogesterone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids, progestogens 1659 71-58-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • medroxyprogesterone
  • medroxyprogesterone acetate
  • medoxyprogesterone
  • medroxyprogesteron
  • depomedroxyprogesterone acetate
  • medroprogesterone acetate
  • hysron
A synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
  • Molecular weight: 386.53
  • Formula: C24H34O4
  • CLOGP: 4.20
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 60.44
  • ALOGS: -5.24
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.67 mg P
5 mg O
7 mg P
1 g O
1 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ
S (Water solubility) 0.02 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 44 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.06 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 15 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
June 18, 1959 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Unintended pregnancy 1916.16 10.53 491 37506 5688 63445337
Pregnancy with injectable contraceptive 665.69 10.53 108 37889 32 63450993
Intermenstrual bleeding 404.48 10.53 159 37838 7767 63443258
Incorrect dose administered by device 400.94 10.53 135 37862 4213 63446812
Drug dose omission by device 387.83 10.53 135 37862 4666 63446359
Device leakage 319.23 10.53 130 37867 6966 63444059
Syringe issue 316.46 10.53 102 37895 2767 63448258
Heavy menstrual bleeding 276.55 10.53 157 37840 17616 63433409
Injection site abscess 233.25 10.53 66 37931 1132 63449893
Needle issue 224.11 10.53 114 37883 10262 63440763
Amenorrhoea 214.35 10.53 109 37888 9805 63441220
Device occlusion 207.10 10.53 97 37900 7290 63443735
Vaginal haemorrhage 196.02 10.53 149 37848 27338 63423687
Breast cancer 183.67 10.53 183 37814 48200 63402825
Osteopenia 169.91 10.53 120 37877 19665 63431360
Depression 144.60 10.53 345 37652 196147 63254878
Device issue 141.74 10.53 116 37881 23665 63427360
Contraindicated product administered 109.17 10.53 5 37992 217643 63233382
Oestrogen receptor assay positive 107.84 10.53 30 37967 482 63450543
Fibrocystic breast disease 101.99 10.53 35 37962 1157 63449868
Glossodynia 93.47 10.53 3 37994 178873 63272152
Injection site atrophy 92.44 10.53 28 37969 615 63450410
Uterine perforation 85.98 10.53 53 37944 6910 63444115
Menstruation irregular 85.69 10.53 53 37944 6951 63444074
Treatment failure 84.51 10.53 10 37987 199033 63251992
Progesterone receptor assay positive 84.02 10.53 23 37974 347 63450678
Pulmonary embolism 83.69 10.53 203 37794 116481 63334544
Breast cancer in situ 83.10 10.53 32 37965 1476 63449549
Pelvic pain 82.77 10.53 67 37930 13452 63437573
Incorrect dose administered 81.20 10.53 136 37861 59832 63391193
Device mechanical issue 77.13 10.53 20 37977 242 63450783
Clear cell renal cell carcinoma 76.47 10.53 30 37967 1455 63449570
Joint swelling 74.03 10.53 53 37944 327613 63123412
Drug intolerance 73.65 10.53 47 37950 308614 63142411
Uterine leiomyoma 72.56 10.53 53 37944 9145 63441880
Dysmenorrhoea 72.49 10.53 39 37958 3934 63447091
Death 71.77 10.53 71 37926 374310 63076715
Breast calcifications 70.00 10.53 27 37970 1251 63449774
Breast cancer female 68.19 10.53 60 37937 13499 63437526
Uterine haemorrhage 66.36 10.53 37 37960 4004 63447021
Postmenopausal haemorrhage 65.88 10.53 30 37967 2112 63448913
Anxiety 65.68 10.53 281 37716 217260 63233765
Renal mass 63.19 10.53 30 37967 2323 63448702
Abortion spontaneous 62.51 10.53 106 37891 47089 63403936
Wrong technique in device usage process 61.98 10.53 34 37963 3564 63447461
Hepatic enzyme increased 61.70 10.53 22 37975 202306 63248719
Systemic lupus erythematosus 61.56 10.53 24 37973 208894 63242131
Emotional distress 61.25 10.53 86 37911 32463 63418562
Breast tenderness 60.18 10.53 29 37968 2321 63448704
Rheumatoid arthritis 60.05 10.53 39 37958 253780 63197245
Product administration error 57.50 10.53 69 37928 22328 63428697
Poor quality device used 57.44 10.53 27 37970 2044 63448981
Injury 56.35 10.53 131 37866 73116 63377909
Abdominal discomfort 54.70 10.53 67 37930 320818 63130207
Synovitis 54.20 10.53 22 37975 186896 63264129
Deep vein thrombosis 52.95 10.53 139 37858 83661 63367364
Wound 52.85 10.53 16 37981 163247 63287778
Hot flush 52.64 10.53 103 37894 51056 63399969
Injection site necrosis 51.60 10.53 22 37975 1322 63449703
Product quality issue 50.77 10.53 83 37914 35782 63415243
Pyrexia 50.63 10.53 131 37866 470347 62980678
Infertility female 50.12 10.53 17 37980 542 63450483
Therapeutic product effect decreased 49.45 10.53 27 37970 193160 63257865
Off label use 48.76 10.53 223 37774 674239 62776786
Suppressed lactation 48.74 10.53 16 37981 460 63450565
Exposure via skin contact 47.12 10.53 15 37982 390 63450635
Lower respiratory tract infection 46.53 10.53 11 37986 132296 63318729
Genital haemorrhage 46.29 10.53 37 37960 7295 63443730
Uterine polyp 45.65 10.53 23 37974 2027 63448998
Infusion related reaction 45.37 10.53 48 37949 245473 63205552
Toxicity to various agents 44.95 10.53 49 37948 247201 63203824
Injection site pain 44.93 10.53 175 37822 129625 63321400
Discomfort 44.90 10.53 22 37975 167352 63283673
Breast cancer metastatic 44.72 10.53 45 37952 11973 63439052
Infertility 44.57 10.53 17 37980 764 63450261
Pericarditis 42.39 10.53 13 37984 131566 63319459
Cerebrovascular accident 41.84 10.53 151 37846 107873 63343152
Poor quality product administered 41.47 10.53 25 37972 3131 63447894
Breast disorder 38.40 10.53 22 37975 2508 63448517
Menstrual disorder 38.29 10.53 29 37968 5284 63445741
Pneumonia 37.28 10.53 144 37853 456623 62994402
Cholecystitis chronic 37.10 10.53 38 37959 10323 63440702
Mood swings 37.01 10.53 50 37947 18198 63432827
Diarrhoea 36.85 10.53 264 37733 715102 62735923
Helicobacter infection 36.21 10.53 6 37991 92779 63358246
Osteoporosis 36.10 10.53 95 37902 57243 63393782
Endometrial hyperplasia 35.77 10.53 15 37982 865 63450160
Acute kidney injury 35.17 10.53 65 37932 263350 63187675
Scar 34.63 10.53 42 37955 13740 63437285
Product use issue 34.52 10.53 49 37948 220471 63230554
Mammogram abnormal 34.42 10.53 14 37983 747 63450278
Hyperlipidaemia 34.30 10.53 50 37947 19521 63431504
Mood altered 33.94 10.53 43 37954 14700 63436325
Peripheral swelling 33.44 10.53 68 37929 265874 63185151
Blister 33.42 10.53 18 37979 129796 63321229
Stomatitis 33.21 10.53 21 37976 138704 63312321
Arthropathy 33.09 10.53 56 37941 234736 63216289
Device dislocation 33.06 10.53 57 37940 25648 63425377
Sepsis 32.94 10.53 26 37971 153097 63297928
Infection 32.91 10.53 54 37943 229119 63221906
Spinal osteoarthritis 32.29 10.53 44 37953 16142 63434883
Injection site panniculitis 32.11 10.53 5 37992 0 63451025
Device breakage 32.02 10.53 37 37960 11505 63439520
Endometrial cancer 31.06 10.53 21 37976 3204 63447821
Device delivery system issue 30.90 10.53 13 37984 756 63450269
Gastrooesophageal reflux disease 30.72 10.53 126 37871 95513 63355512
Low turnover osteopathy 30.51 10.53 23 37974 4162 63446863
Exostosis of jaw 30.29 10.53 15 37982 1274 63449751
Confusional state 30.09 10.53 60 37937 236320 63214705
Bone density decreased 29.57 10.53 40 37957 14572 63436453
Haemorrhage 29.56 10.53 92 37905 60930 63390095
Abdominal pain lower 29.25 10.53 54 37943 25624 63425401
Suicidal ideation 29.22 10.53 93 37904 62328 63388697
Incorrect route of product administration 29.12 10.53 56 37941 27396 63423629
Folliculitis 28.69 10.53 4 37993 70313 63380712
Therapeutic product effect incomplete 28.49 10.53 20 37977 125036 63325989
Pregnancy test positive 28.44 10.53 8 37989 134 63450891
Scoliosis 28.37 10.53 29 37968 7859 63443166
Coronary artery disease 28.35 10.53 61 37936 32316 63418709
Breast mass 28.27 10.53 29 37968 7893 63443132
Musculoskeletal stiffness 27.93 10.53 42 37955 184576 63266449
Ectopic pregnancy 27.84 10.53 18 37979 2549 63448476
Injection site inflammation 27.75 10.53 21 37976 3822 63447203
Fatigue 27.46 10.53 371 37626 887657 62563368
Eosinopenia 26.60 10.53 6 37991 38 63450987
Urticaria 26.51 10.53 180 37817 165622 63285403
Cervical dysplasia 26.44 10.53 19 37978 3195 63447830
Neutropenia 26.29 10.53 40 37957 174965 63276060
C-reactive protein increased 26.08 10.53 12 37985 94695 63356330
Breast hyperplasia 26.07 10.53 9 37988 303 63450722
Rash 25.99 10.53 213 37784 560658 62890367
Intentional product use issue 25.93 10.53 23 37974 127869 63323156
Intervertebral disc degeneration 25.86 10.53 39 37958 15693 63435332
General physical health deterioration 25.73 10.53 51 37946 201351 63249674
Swelling 25.66 10.53 82 37915 275296 63175729
Injection site indentation 25.58 10.53 8 37989 196 63450829
Device failure 25.15 10.53 24 37973 5987 63445038
Abnormal uterine bleeding 24.96 10.53 14 37983 1532 63449493
Stress urinary incontinence 24.28 10.53 16 37981 2339 63448686
Hyponatraemia 24.06 10.53 19 37978 111881 63339144
Dyspareunia 23.68 10.53 16 37981 2439 63448586
Embedded device 22.89 10.53 18 37979 3465 63447560
Device difficult to use 22.87 10.53 33 37964 12763 63438262
Product complaint 22.85 10.53 33 37964 12776 63438249
Breast cyst 22.83 10.53 14 37983 1807 63449218
Device use issue 22.68 10.53 16 37981 2614 63448411
Dental caries 22.57 10.53 30 37967 10749 63440276
Biopsy breast abnormal 22.54 10.53 5 37992 29 63450996
Osteonecrosis 22.38 10.53 47 37950 24483 63426542
Alopecia 22.32 10.53 115 37882 337421 63113604
Cerebral venous sinus thrombosis 21.81 10.53 14 37983 1958 63449067
Menometrorrhagia 21.66 10.53 11 37986 986 63450039
Mastectomy 21.62 10.53 13 37984 1620 63449405
Diabetes mellitus 21.58 10.53 78 37919 55732 63395293
Diverticulum 21.54 10.53 31 37966 11960 63439065
Ill-defined disorder 21.53 10.53 11 37986 81744 63369281
Injection site discolouration 21.50 10.53 25 37972 7823 63443202
Vaginal odour 21.43 10.53 9 37988 521 63450504
Completed suicide 21.20 10.53 34 37963 145639 63305386
Breast conserving surgery 21.13 10.53 11 37986 1038 63449987
Abortion missed 21.01 10.53 13 37984 1706 63449319
Mobility decreased 20.92 10.53 25 37972 121134 63329891
Emotional disorder 20.35 10.53 32 37965 13347 63437678
Oligomenorrhoea 20.28 10.53 10 37987 841 63450184
Migraine 20.12 10.53 118 37879 103228 63347797
Muscle injury 20.08 10.53 7 37990 65338 63385687
Uterine disorder 20.02 10.53 16 37981 3153 63447872
Fracture nonunion 19.88 10.53 14 37983 2281 63448744
Endometrial cancer stage I 19.62 10.53 7 37990 260 63450765
Adnexa uteri pain 19.50 10.53 8 37989 436 63450589
Injection site reaction 19.50 10.53 78 37919 58446 63392579
Cardiac failure 19.34 10.53 15 37982 89127 63361898
Withdrawal bleed 19.32 10.53 5 37992 60 63450965
Resorption bone increased 19.12 10.53 11 37986 1263 63449762
Device deployment issue 19.09 10.53 17 37980 3885 63447140
Vulvovaginal dryness 19.08 10.53 15 37982 2886 63448139
Skin laceration 18.99 10.53 42 37955 22666 63428359
Urine leukocyte esterase 18.85 10.53 6 37991 156 63450869
Anaphylactic reaction 18.84 10.53 84 37913 66016 63385009
Drug abuse 18.74 10.53 10 37987 72508 63378517
Uterine pain 18.73 10.53 7 37990 297 63450728
Endometrial atrophy 18.55 10.53 5 37992 71 63450954
Muscle fatigue 18.49 10.53 14 37983 2550 63448475
Disease progression 18.49 10.53 28 37969 122730 63328295
Cervicitis 18.47 10.53 8 37989 500 63450525
Angina unstable 18.44 10.53 22 37975 7073 63443952
Procedural pain 18.16 10.53 40 37957 21529 63429496
Knee arthroplasty 18.10 10.53 5 37992 54201 63396824
Intentional overdose 18.05 10.53 11 37986 74141 63376884
Adenomyosis 18.02 10.53 8 37989 530 63450495
Stress fracture 17.97 10.53 23 37974 7940 63443085
Coma 17.96 10.53 8 37989 64356 63386669
Pregnancy with implant contraceptive 17.92 10.53 14 37983 2669 63448356
Internal injury 17.85 10.53 7 37990 339 63450686
Deformity 17.84 10.53 28 37969 11656 63439369
Thyrotoxic periodic paralysis 17.78 10.53 4 37993 25 63451000
Postmortem blood drug level abnormal 17.62 10.53 7 37990 351 63450674
Osteomyelitis 17.29 10.53 44 37953 25976 63425049
Liquid product physical issue 17.20 10.53 10 37987 1172 63449853
Medical device discomfort 17.20 10.53 12 37985 1927 63449098
Device defective 17.07 10.53 12 37985 1950 63449075
Gastrointestinal disorder 16.96 10.53 33 37964 131206 63319819
Placenta accreta 16.89 10.53 6 37991 220 63450805
Benign breast neoplasm 16.75 10.53 10 37987 1230 63449795
Decidual cast 16.73 10.53 3 37994 4 63451021
Femur fracture 16.69 10.53 59 37938 41697 63409328
Delayed puberty 16.67 10.53 5 37992 106 63450919
Delirium 16.26 10.53 5 37992 50536 63400489
Breast reconstruction 16.18 10.53 6 37991 249 63450776
Liver injury 16.15 10.53 8 37989 60512 63390513
Acne 16.11 10.53 40 37957 23253 63427772
Febrile neutropenia 15.99 10.53 29 37968 118420 63332605
Neurofibroma 15.97 10.53 3 37994 6 63451019
Blood oestrogen decreased 15.89 10.53 6 37991 262 63450763
Libido decreased 15.84 10.53 13 37984 2659 63448366
Renal failure 15.71 10.53 29 37968 117623 63333402
Pancytopenia 15.69 10.53 21 37976 96912 63354113
Psoriatic arthropathy 15.67 10.53 19 37978 91501 63359524
Oral infection 15.62 10.53 17 37980 4951 63446074
Thrombocytopenia 15.51 10.53 43 37954 151114 63299911
Renal impairment 15.50 10.53 18 37979 88337 63362688
Toothache 15.48 10.53 35 37962 19164 63431861
Modified radical mastectomy 15.37 10.53 3 37994 8 63451017
Weight increased 15.33 10.53 230 37767 260562 63190463
Meniscus injury 15.20 10.53 20 37977 7094 63443931
Complication of device removal 15.14 10.53 17 37980 5125 63445900
Uterine injury 15.02 10.53 4 37993 54 63450971
Cerebral palsy 14.94 10.53 5 37992 153 63450872
Intentional device misuse 14.93 10.53 8 37989 800 63450225
Endometrial hypertrophy 14.91 10.53 6 37991 311 63450714
Lipoatrophy 14.81 10.53 6 37991 317 63450708
Livedo reticularis 14.77 10.53 12 37985 2420 63448605
Liver iron concentration abnormal 14.76 10.53 4 37993 58 63450967
Oestrogen deficiency 14.75 10.53 5 37992 159 63450866
Breast necrosis 14.72 10.53 5 37992 160 63450865
Large intestine polyp 14.52 10.53 21 37976 8136 63442889
Galactorrhoea 14.45 10.53 15 37982 4140 63446885
Product packaging issue 14.43 10.53 9 37988 1197 63449828
Foot fracture 14.42 10.53 39 37958 23875 63427150
Lumbar spinal stenosis 14.29 10.53 16 37981 4806 63446219
Injection site abscess sterile 14.07 10.53 3 37994 14 63451011
Cardiac arrest 14.04 10.53 21 37976 92524 63358501
Intramedullary rod insertion 14.01 10.53 11 37986 2112 63448913
Chlamydial infection 14.00 10.53 6 37991 365 63450660
Injection site induration 13.94 10.53 22 37975 9204 63441821
Mitral valve incompetence 13.93 10.53 34 37963 19560 63431465
Bradycardia 13.86 10.53 14 37983 73213 63377812
Anhedonia 13.67 10.53 24 37973 10950 63440075
Radiotherapy 13.58 10.53 6 37991 393 63450632
Loss of libido 13.51 10.53 9 37988 1340 63449685
Circumstance or information capable of leading to medication error 13.51 10.53 14 37983 3856 63447169
Anaemia postoperative 13.49 10.53 11 37986 2231 63448794
Immunoglobulin G4 related disease 13.42 10.53 4 37993 83 63450942
Breast pain 13.32 10.53 21 37976 8777 63442248
Uterine spasm 13.31 10.53 7 37990 674 63450351
Post procedural cellulitis 13.28 10.53 4 37993 86 63450939
Inappropriate schedule of product administration 13.26 10.53 107 37890 103858 63347167
Crystalluria 13.25 10.53 6 37991 417 63450608
Hospitalisation 13.20 10.53 19 37978 85062 63365963
Hip arthroplasty 13.17 10.53 6 37991 47640 63403385
Pituitary tumour recurrent 13.16 10.53 4 37993 89 63450936
Injection site discomfort 13.11 10.53 15 37982 4615 63446410
Muscle spasms 13.08 10.53 147 37850 156003 63295022
Seborrhoeic keratosis 13.07 10.53 11 37986 2331 63448694
Panic attack 13.04 10.53 36 37961 22295 63428730
Red blood cell sedimentation rate increased 13.02 10.53 5 37992 43977 63407048
Hyperkeratosis 12.99 10.53 17 37980 6001 63445024
Mitral valve prolapse 12.86 10.53 11 37986 2382 63448643
Myocardial infarction 12.84 10.53 103 37894 99790 63351235
Mucosal inflammation 12.83 10.53 6 37991 46922 63404103
Drug ineffective for unapproved indication 12.65 10.53 47 37950 34016 63417009
Complication associated with device 12.65 10.53 30 37967 16948 63434077
Osteoarthritis 12.63 10.53 99 37898 95244 63355781
Fine motor skill dysfunction 12.60 10.53 15 37982 4810 63446215
Gingivitis 12.60 10.53 20 37977 8409 63442616
Menopausal symptoms 12.59 10.53 11 37986 2450 63448575
Anticonvulsant drug level increased 12.55 10.53 9 37988 1508 63449517
Post procedural discomfort 12.55 10.53 8 37989 1106 63449919
Tic 12.54 10.53 9 37988 1511 63449514
Cartilage injury 12.53 10.53 10 37987 1967 63449058
Nasopharyngitis 12.46 10.53 95 37902 254162 63196863
Pregnancy test urine positive 12.37 10.53 3 37994 27 63450998
Uterine cervix stenosis 12.32 10.53 5 37992 265 63450760
Insomnia 12.32 10.53 189 37808 215063 63235962
Medical device pain 12.23 10.53 9 37988 1571 63449454
Acne cystic 12.12 10.53 6 37991 509 63450516
Product administered at inappropriate site 12.10 10.53 12 37985 3137 63447888
Breast fibrosis 12.00 10.53 3 37994 31 63450994
Respiratory failure 11.99 10.53 27 37970 101831 63349194
Fear 11.90 10.53 28 37969 15738 63435287
Cardio-respiratory arrest 11.89 10.53 11 37986 59948 63391077
Nocturia 11.73 10.53 19 37978 8122 63442903
Ovarian cyst 11.69 10.53 28 37969 15917 63435108
Injection site cellulitis 11.68 10.53 8 37989 1246 63449779
HIV test positive 11.67 10.53 3 37994 35 63450990
Gallbladder disorder 11.63 10.53 31 37966 18811 63432214
Adenoma benign 11.61 10.53 7 37990 877 63450148
Cholecystectomy 11.59 10.53 22 37975 10655 63440370
Thyroid disorder 11.52 10.53 27 37970 15135 63435890
Breast disorder female 11.52 10.53 4 37993 137 63450888
Anger 11.52 10.53 24 37973 12432 63438593
Endometriosis 11.44 10.53 15 37982 5305 63445720
Hepatic function abnormal 11.37 10.53 4 37993 37138 63413887
Maternal exposure during pregnancy 11.36 10.53 81 37916 219981 63231044
Atrophic vulvovaginitis 11.33 10.53 9 37988 1759 63449266
Pregnancy with contraceptive device 11.30 10.53 14 37983 4680 63446345
Hypothyroidism 11.27 10.53 53 37944 42579 63408446
Protein urine present 11.26 10.53 16 37981 6104 63444921
Drug exposure before pregnancy 11.25 10.53 7 37990 927 63450098
Ventricular hypertrophy 11.23 10.53 12 37985 3424 63447601
Wrong product administered 11.21 10.53 16 37981 6125 63444900
Feelings of worthlessness 11.16 10.53 5 37992 339 63450686
Complication of pregnancy 11.07 10.53 6 37991 614 63450411
Condition aggravated 10.97 10.53 172 37825 402045 63048980
Cervicobrachial syndrome 10.96 10.53 7 37990 970 63450055
Dehydration 10.92 10.53 60 37937 173294 63277731
Hirsutism 10.92 10.53 8 37989 1387 63449638
Marital problem 10.84 10.53 4 37993 164 63450861
Therapy interrupted 10.82 10.53 3 37994 32452 63418573
Fat necrosis 10.72 10.53 6 37991 654 63450371
Porphyria 10.70 10.53 4 37993 170 63450855
Hypotension 10.64 10.53 108 37889 272496 63178529
Injection site infection 10.58 10.53 9 37988 1934 63449091
Hormone level abnormal 10.55 10.53 10 37987 2473 63448552

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Head titubation 118.88 36.16 18 754 393 34955766
Cogwheel rigidity 97.47 36.16 18 754 1334 34954825
Sedation complication 74.38 36.16 15 757 1762 34954397
Extrapyramidal disorder 74.25 36.16 22 750 12858 34943301
Serotonin syndrome 64.80 36.16 22 750 19911 34936248
Anticholinergic syndrome 54.80 36.16 11 761 1258 34954901
Porphyria non-acute 38.36 36.16 7 765 482 34955677
Sexually inappropriate behaviour 38.04 36.16 7 765 505 34955654
Exposure during pregnancy 37.58 36.16 12 760 8922 34947237

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Unintended pregnancy 1097.00 11.47 261 29134 3672 79711321
Pregnancy with injectable contraceptive 539.41 11.47 82 29313 32 79714961
Intermenstrual bleeding 273.97 11.47 97 29298 5787 79709206
Vaginal haemorrhage 199.17 11.47 115 29280 21702 79693291
Incorrect dose administered by device 197.66 11.47 73 29322 4916 79710077
Amenorrhoea 196.83 11.47 82 29313 7610 79707383
Drug dose omission by device 192.10 11.47 76 29319 6174 79708819
Heavy menstrual bleeding 186.95 11.47 95 29300 13916 79701077
Injection site abscess 158.25 11.47 47 29348 1593 79713400
Osteopenia 152.35 11.47 91 29304 18273 79696720
Depression 149.16 11.47 278 29117 216512 79498481
Device leakage 120.26 11.47 65 29330 10791 79704202
Needle issue 119.56 11.47 69 29326 12999 79701994
Uterine perforation 108.89 11.47 51 29344 6252 79708741
Oestrogen receptor assay positive 108.27 11.47 25 29370 305 79714688
Injection site atrophy 102.22 11.47 25 29370 396 79714597
Breast cancer in situ 95.16 11.47 28 29367 918 79714075
Syringe issue 90.75 11.47 45 29350 6253 79708740
Fibrocystic breast disease 90.69 11.47 25 29370 645 79714348
Device issue 88.26 11.47 76 29319 27032 79687961
Abortion spontaneous 86.62 11.47 78 29317 29429 79685564
Menstruation irregular 84.69 11.47 40 29355 4996 79709997
Progesterone receptor assay positive 82.50 11.47 19 29376 229 79714764
Pelvic pain 80.20 11.47 54 29341 13327 79701666
Breast cancer 77.64 11.47 78 29317 33703 79681290
Death 76.91 11.47 58 29337 566456 79148537
Uterine leiomyoma 75.36 11.47 40 29355 6403 79708590
Injury 75.26 11.47 116 29279 77380 79637613
Clear cell renal cell carcinoma 74.55 11.47 30 29365 2546 79712447
Pulmonary embolism 68.57 11.47 177 29218 171477 79543516
Emotional distress 68.47 11.47 79 29316 39890 79675103
Renal mass 67.04 11.47 30 29365 3310 79711683
Postmenopausal haemorrhage 62.54 11.47 23 29372 1529 79713464
Genital haemorrhage 62.52 11.47 35 29360 6220 79708773
Acute kidney injury 62.14 11.47 60 29335 519344 79195649
Uterine haemorrhage 61.24 11.47 27 29368 2876 79712117
Anxiety 59.44 11.47 214 29181 248298 79466695
Breast cancer female 58.71 11.47 42 29353 11419 79703574
Device dislocation 52.53 11.47 56 29339 25914 79689079
Device occlusion 50.72 11.47 39 29356 11827 79703166
Pyrexia 49.31 11.47 111 29284 678598 79036395
Uterine polyp 47.76 11.47 19 29376 1565 79713428
Breast calcifications 46.67 11.47 16 29379 866 79714127
Contraindicated product administered 46.23 11.47 3 29392 157535 79557458
Dysmenorrhoea 44.59 11.47 22 29373 3023 79711970
Neutropenia 43.61 11.47 26 29369 287684 79427309
Hot flush 42.25 11.47 74 29321 54803 79660190
Injection site necrosis 42.04 11.47 17 29378 1461 79713532
Pneumonia 41.70 11.47 116 29279 660130 79054863
Sepsis 41.33 11.47 24 29371 269404 79445589
Treatment failure 40.53 11.47 7 29388 170479 79544514
Osteoporosis 40.41 11.47 72 29323 54040 79660953
Toxicity to various agents 40.39 11.47 58 29337 421482 79293511
Injection site pain 39.18 11.47 121 29274 129717 79585276
Cholecystitis chronic 38.97 11.47 31 29364 9875 79705118
Menstrual disorder 38.60 11.47 22 29373 4045 79710948
Cerebrovascular accident 37.32 11.47 134 29261 155158 79559835
Gastrooesophageal reflux disease 37.05 11.47 103 29292 104143 79610850
Mood swings 36.94 11.47 41 29354 19839 79695154
Drug abuse 35.90 11.47 8 29387 162683 79552310
Scoliosis 35.16 11.47 26 29369 7438 79707555
Injection site panniculitis 34.53 11.47 5 29390 0 79714993
Dyspareunia 34.46 11.47 16 29379 1922 79713071
Mammogram abnormal 34.41 11.47 11 29384 478 79714515
Abdominal pain lower 34.30 11.47 50 29345 31732 79683261
Product administration error 34.22 11.47 50 29345 31796 79683197
Exostosis of jaw 34.22 11.47 14 29381 1240 79713753
Low turnover osteopathy 34.09 11.47 16 29379 1970 79713023
Breast disorder 33.38 11.47 16 29379 2065 79712928
Endometrial cancer 33.28 11.47 16 29379 2078 79712915
Scar 32.93 11.47 34 29361 15162 79699831
Abnormal uterine bleeding 32.80 11.47 13 29382 1060 79713933
Stress urinary incontinence 32.08 11.47 15 29380 1831 79713162
Breast tenderness 32.07 11.47 16 29379 2252 79712741
Poor quality device used 31.95 11.47 16 29379 2269 79712724
Embedded device 31.63 11.47 18 29377 3301 79711692
Endometrial hyperplasia 31.57 11.47 11 29384 625 79714368
Wrong technique in device usage process 30.92 11.47 19 29376 4009 79710984
Off label use 29.88 11.47 204 29191 907011 78807982
Porphyria non-acute 29.81 11.47 11 29384 738 79714255
Hyperlipidaemia 29.54 11.47 42 29353 26051 79688942
Vulvovaginal dryness 29.42 11.47 15 29380 2209 79712784
Pregnancy test positive 29.36 11.47 7 29388 99 79714894
Device breakage 28.94 11.47 27 29368 10648 79704345
Urticaria 28.90 11.47 140 29255 185061 79529932
Spinal osteoarthritis 28.22 11.47 33 29362 16894 79698099
Osteonecrosis 28.02 11.47 45 29350 31050 79683943
Migraine 27.75 11.47 83 29312 87410 79627583
Eosinopenia 27.74 11.47 6 29389 53 79714940
Device failure 27.69 11.47 21 29374 6240 79708753
Deformity 27.41 11.47 25 29370 9580 79705413
Procedural pain 27.39 11.47 38 29357 23046 79691947
Infertility female 27.13 11.47 9 29386 440 79714553
Hepatic enzyme increased 26.96 11.47 17 29378 182593 79532400
Osteoarthritis 26.92 11.47 82 29313 87227 79627766
Complication of device removal 26.48 11.47 17 29378 3872 79711121
Deep vein thrombosis 26.25 11.47 101 29294 120818 79594175
Cerebral venous sinus thrombosis 26.16 11.47 14 29381 2277 79712716
Hyponatraemia 25.65 11.47 17 29378 177831 79537162
Intervertebral disc degeneration 25.03 11.47 30 29365 15755 79699238
Endometrial cancer stage I 24.98 11.47 7 29388 192 79714801
Benign breast neoplasm 24.81 11.47 10 29385 852 79714141
Dental caries 24.81 11.47 26 29369 11794 79703199
Breast reconstruction 24.30 11.47 6 29389 99 79714894
Renal failure 24.22 11.47 23 29372 200945 79514048
Exposure during pregnancy 24.05 11.47 87 29308 101045 79613948
Device mechanical issue 24.02 11.47 8 29387 396 79714597
Head titubation 23.99 11.47 10 29385 928 79714065
Febrile neutropenia 23.91 11.47 30 29365 230969 79484024
Toothache 23.88 11.47 33 29362 19937 79695056
Uterine disorder 23.84 11.47 13 29382 2194 79712799
Device difficult to use 23.83 11.47 27 29368 13358 79701635
Medical device discomfort 23.70 11.47 12 29383 1742 79713251
Completed suicide 23.33 11.47 34 29361 245733 79469260
Infertility 23.21 11.47 9 29386 692 79714301
Cardiac arrest 22.80 11.47 18 29377 172078 79542915
Diarrhoea 22.49 11.47 212 29183 880277 78834716
Injection site reaction 22.36 11.47 57 29338 54728 79660265
Bradycardia 22.35 11.47 11 29384 135546 79579447
Adenomyosis 22.15 11.47 7 29388 293 79714700
Thrombocytopenia 22.08 11.47 40 29355 265219 79449774
Cardiac failure 22.06 11.47 15 29380 154827 79560166
Lower respiratory tract infection 22.05 11.47 10 29385 129210 79585783
Weight increased 21.92 11.47 176 29219 277210 79437783
Diabetes mellitus 21.75 11.47 71 29324 78319 79636674
Rheumatoid arthritis 21.65 11.47 27 29368 208443 79506550
Exposure via skin contact 21.51 11.47 7 29388 322 79714671
Confusional state 21.43 11.47 54 29341 317943 79397050
Product quality issue 21.39 11.47 42 29353 33898 79681095
Injection site inflammation 21.36 11.47 15 29380 3961 79711032
Cervical dysplasia 21.35 11.47 12 29383 2149 79712844
Insomnia 21.28 11.47 159 29236 245011 79469982
Adnexa uteri pain 21.09 11.47 7 29388 343 79714650
Joint swelling 21.06 11.47 47 29348 288599 79426394
Ectopic pregnancy 20.89 11.47 11 29384 1732 79713261
Injection site indentation 20.71 11.47 6 29389 186 79714807
Emotional disorder 20.65 11.47 26 29369 14361 79700632
Therapeutic product effect decreased 20.64 11.47 18 29377 163845 79551148
Bone density decreased 20.57 11.47 25 29370 13322 79701671
Internal injury 20.54 11.47 7 29388 372 79714621
C-reactive protein increased 20.48 11.47 11 29384 129016 79585977
Urine leukocyte esterase 20.44 11.47 6 29389 195 79714798
Pregnancy with contraceptive device 20.13 11.47 14 29381 3640 79711353
Breast mass 20.10 11.47 18 29377 6736 79708257
Disease progression 20.08 11.47 23 29372 184339 79530654
Vaginal odour 19.76 11.47 7 29388 418 79714575
Resorption bone increased 19.67 11.47 10 29385 1465 79713528
Pericarditis 19.52 11.47 7 29388 104229 79610764
Oligomenorrhoea 19.45 11.47 8 29387 718 79714275
Fracture nonunion 19.37 11.47 10 29385 1512 79713481
Drug intolerance 19.27 11.47 43 29352 264076 79450917
Renal impairment 19.08 11.47 18 29377 157765 79557228
Intentional device misuse 18.85 11.47 8 29387 777 79714216
Gallbladder disorder 18.83 11.47 29 29366 19311 79695682
Stress fracture 18.76 11.47 17 29378 6463 79708530
Osteomyelitis 18.72 11.47 39 29356 32826 79682167
Oral infection 18.57 11.47 16 29379 5691 79709302
Therapeutic product effect incomplete 18.53 11.47 15 29380 141630 79573363
Skin laceration 18.45 11.47 36 29359 28926 79686067
Prolactin-producing pituitary tumour 18.44 11.47 5 29390 121 79714872
Maternal drugs affecting foetus 18.42 11.47 10 29385 1673 79713320
Ovarian cyst 18.37 11.47 23 29372 12632 79702361
General physical health deterioration 18.34 11.47 47 29348 275191 79439802
Muscle fatigue 18.26 11.47 13 29382 3506 79711487
Modified radical mastectomy 18.18 11.47 3 29392 4 79714989
Decidual cast 18.18 11.47 3 29392 4 79714989
Drug interaction 18.14 11.47 85 29310 415098 79299895
Abortion missed 17.99 11.47 9 29386 1274 79713719
Breast cyst 17.96 11.47 9 29386 1278 79713715
Intentional product use issue 17.64 11.47 18 29377 152094 79562899
Lumbar spinal stenosis 17.58 11.47 15 29380 5267 79709726
Breast hyperplasia 17.45 11.47 5 29390 149 79714844
Fine motor skill dysfunction 17.39 11.47 15 29380 5342 79709651
Blood oestrogen decreased 17.35 11.47 5 29390 152 79714841
Synovitis 17.30 11.47 18 29377 150716 79564277
Endometrial atrophy 17.23 11.47 4 29391 50 79714943
Uterine injury 17.23 11.47 4 29391 50 79714943
Respiratory failure 17.19 11.47 25 29370 180886 79534107
Medical device pain 17.06 11.47 9 29386 1422 79713571
Menopausal symptoms 16.99 11.47 10 29385 1953 79713040
Ovarian cancer 16.97 11.47 13 29382 3921 79711072
Postmortem blood drug level abnormal 16.82 11.47 7 29388 647 79714346
Post procedural discomfort 16.69 11.47 8 29387 1032 79713961
Liver iron concentration abnormal 16.68 11.47 4 29391 58 79714935
Complication of pregnancy 16.67 11.47 6 29389 375 79714618
Pancytopenia 16.65 11.47 22 29373 165723 79549270
Uterine pain 16.49 11.47 5 29390 182 79714811
Cartilage injury 16.42 11.47 9 29386 1534 79713459
Delayed puberty 16.36 11.47 5 29390 187 79714806
Stomatitis 16.31 11.47 18 29377 146739 79568254
Coronary artery disease 16.14 11.47 57 29338 65417 79649576
Cerebral palsy 16.13 11.47 5 29390 196 79714797
Device use issue 16.12 11.47 11 29384 2773 79712220
Foot fracture 16.09 11.47 29 29366 21952 79693041
Post procedural cellulitis 15.98 11.47 4 29391 70 79714923
Suicidal ideation 15.94 11.47 63 29332 76277 79638716
Placenta accreta 15.85 11.47 5 29390 208 79714785
Throat tightness 15.76 11.47 33 29362 27874 79687119
Biopsy breast abnormal 15.70 11.47 3 29392 13 79714980
Galactorrhoea 15.62 11.47 12 29383 3634 79711359
Uterine cervix stenosis 15.58 11.47 5 29390 220 79714773
Discomfort 15.58 11.47 14 29381 125603 79589390
Wound 15.58 11.47 12 29383 116167 79598826
Femur fracture 15.55 11.47 40 29355 38612 79676381
Intentional overdose 15.45 11.47 10 29385 105950 79609043
Diverticulum 15.44 11.47 23 29372 14873 79700120
Breast necrosis 15.43 11.47 4 29391 81 79714912
Oestrogen deficiency 15.38 11.47 4 29391 82 79714911
Coma 15.37 11.47 9 29386 100640 79614353
Hyperkalaemia 15.10 11.47 12 29383 114386 79600607
Septic shock 14.85 11.47 14 29381 122787 79592206
Cardio-respiratory arrest 14.81 11.47 11 29384 108499 79606494
Infection 14.81 11.47 43 29352 241669 79473324
Uterine spasm 14.67 11.47 6 29389 531 79714462
Interstitial lung disease 14.63 11.47 12 29383 112588 79602405
Sexually inappropriate behaviour 14.58 11.47 6 29389 539 79714454
Meniscus injury 14.41 11.47 15 29380 6753 79708240
Hyperkeratosis 14.36 11.47 16 29379 7774 79707219
Blood cholesterol increased 14.30 11.47 65 29330 83655 79631338
Lumbar radiculopathy 14.26 11.47 9 29386 1990 79713003
Gingivitis 14.07 11.47 17 29378 9004 79705989
Unwanted pregnancy 14.03 11.47 3 29392 25 79714968
Blister 14.01 11.47 14 29381 119462 79595531
Mitral valve prolapse 13.83 11.47 9 29386 2098 79712895
Premature menopause 13.82 11.47 6 29389 616 79714377
Atrial fibrillation 13.80 11.47 33 29362 197853 79517140
Drug exposure before pregnancy 13.73 11.47 6 29389 626 79714367
Hepatic function abnormal 13.53 11.47 5 29390 73102 79641891
Cholecystectomy 13.46 11.47 17 29378 9415 79705578
Hypotension 13.46 11.47 101 29294 440216 79274777
Vaginal discharge 13.20 11.47 15 29380 7448 79707545
Hypoaesthesia 13.19 11.47 112 29283 179240 79535753
Platelet count decreased 13.15 11.47 33 29362 194631 79520362
Multiple organ dysfunction syndrome 13.09 11.47 15 29380 120231 79594762
Pain in jaw 12.98 11.47 42 29353 46109 79668884
Menometrorrhagia 12.98 11.47 6 29389 714 79714279
Injection site discolouration 12.95 11.47 15 29380 7599 79707394
Thyrotoxic periodic paralysis 12.90 11.47 4 29391 157 79714836
Cogwheel rigidity 12.87 11.47 10 29385 3078 79711915
Anaphylactic reaction 12.83 11.47 63 29332 83680 79631313
Progesterone decreased 12.82 11.47 3 29392 39 79714954
Nitrite urine present 12.73 11.47 7 29388 1202 79713791
Complication associated with device 12.70 11.47 23 29372 17473 79697520
Mucosal inflammation 12.66 11.47 6 29389 75574 79639419
Bacterial test 12.65 11.47 7 29388 1216 79713777
Spondylolisthesis 12.62 11.47 10 29385 3165 79711828
Helicobacter infection 12.52 11.47 5 29390 69699 79645294
Withdrawal bleed 12.48 11.47 3 29392 44 79714949
Atrophic vulvovaginitis 12.45 11.47 7 29388 1254 79713739
Fear 12.42 11.47 26 29369 21960 79693033
Endometrial hypertrophy 12.38 11.47 4 29391 180 79714813
Pregnancy with implant contraceptive 12.36 11.47 8 29387 1848 79713145
Livedo reticularis 12.34 11.47 11 29384 4092 79710901
Cholelithiasis 12.26 11.47 45 29350 52619 79662374
Pituitary tumour recurrent 12.19 11.47 4 29391 189 79714804
Thyroid disorder 12.17 11.47 20 29375 14059 79700934
Morton's neuralgia 12.12 11.47 3 29392 50 79714943
Device defective 12.11 11.47 8 29387 1912 79713081
Carpal tunnel syndrome 12.10 11.47 24 29371 19504 79695489
Device use error 12.10 11.47 14 29381 7087 79707906
Incorrect dose administered 11.99 11.47 58 29337 76572 79638421
Anticonvulsant drug level increased 11.96 11.47 9 29386 2644 79712349
Mitral valve incompetence 11.95 11.47 30 29365 28535 79686458
Hormone level abnormal 11.81 11.47 8 29387 1994 79712999
Hypoglycaemia 11.80 11.47 12 29383 101582 79613411
Device expulsion 11.71 11.47 28 29367 25833 79689160
Pain in extremity 11.68 11.47 194 29201 364344 79350649
Complex regional pain syndrome 11.64 11.47 8 29387 2040 79712953
Injection site swelling 11.59 11.47 41 29354 47091 79667902
Blood creatinine increased 11.50 11.47 25 29370 155032 79559961
Feeling abnormal 11.49 11.47 99 29296 159100 79555893
Ligament sprain 11.47 11.47 19 29376 13445 79701548

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03AA08 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AA17 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AC06 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens
ATC G03DA02 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS
Pregnen (4) derivatives
ATC G03FA12 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS AND ESTROGENS IN COMBINATION
Progestogens and estrogens, fixed combinations
ATC G03FB06 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS AND ESTROGENS IN COMBINATION
Progestogens and estrogens, sequential preparations
ATC L02AB02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ENDOCRINE THERAPY
HORMONES AND RELATED AGENTS
Progestogens
FDA CS M0447349 Progesterone Congeners
MeSH PA D003270 Contraceptive Agents
MeSH PA D003271 Contraceptive Agents, Female
MeSH PA D000080066 Contraceptive Agents, Hormonal
MeSH PA D003278 Contraceptives, Oral, Hormonal
MeSH PA D003280 Contraceptives, Oral, Synthetic
MeSH PA D012102 Reproductive Control Agents
CHEBI has role CHEBI:49323 contraceptive drugs
CHEBI has role CHEBI:49326 synthetic oral contraceptives
CHEBI has role CHEBI:59826 progestins
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:35222 inhibitor
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:49324 female contraceptive drugs
CHEBI has role CHEBI:50113 androgene
CHEBI has role CHEBI:60809 adjuvants
FDA EPC N0000175602 Progestin
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D003272 Contraceptive Agents, Male

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Contraception indication 13197004
Dysfunctional uterine bleeding indication 19155002
Atrophic vaginitis indication 52441000
Secondary physiologic amenorrhea indication 86030004
Secondary malignant neoplasm of kidney indication 94360002
Postmenopausal osteoporosis indication 102447009
Endometriosis indication 129103003
Menopausal flushing indication 198436008
Endometrial carcinoma indication 254878006 DOID:2871
Prevention of premature ovulation during controlled ovarian stimulation indication 732970000
Endometrial Hyperplasia Prevention indication
Polycystic ovaries off-label use 69878008
Precocious puberty off-label use 400179000
Endogenous Estrogen Production Test off-label use
Hyperlipoproteinemia contraindication 3744001 DOID:1168
Hypocalcemia contraindication 5291005
Alcoholism contraindication 7200002
Weight gain finding contraindication 8943002
Hypercholesterolemia contraindication 13644009
Myocardial infarction contraindication 22298006 DOID:5844
Fibroadenosis of breast contraindication 23260002 DOID:10352
Depressive disorder contraindication 35489007
Chloasma contraindication 36209000
Migraine contraindication 37796009 DOID:6364
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Body fluid retention contraindication 43498006
Thrombosis of retinal vein contraindication 46085004
Humoral hypercalcemia of malignancy contraindication 47709007
Dementia contraindication 52448006
Hepatic porphyria contraindication 55056006 DOID:3133
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Hyperlipidemia contraindication 55822004 DOID:1168
Anorexia nervosa contraindication 56882008 DOID:8689
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Thrombophlebitis contraindication 64156001 DOID:3875
Osteoporosis contraindication 64859006 DOID:11476
Intermenstrual bleeding - irregular contraindication 64996003
Diabetes mellitus contraindication 73211009 DOID:9351
Epilepsy contraindication 84757009 DOID:1826
Breast lump contraindication 89164003
Kidney disease contraindication 90708001 DOID:557
Uterine leiomyoma contraindication 95315005 DOID:13223
Deep venous thrombosis contraindication 128053003
Mammography abnormal contraindication 168750009
Asthma contraindication 195967001 DOID:2841
Cerebrovascular accident contraindication 230690007
Pulmonary thromboembolism contraindication 233935004
Thrombophilia contraindication 234467004 DOID:2452
Disease of liver contraindication 235856003 DOID:409
Chorea contraindication 271700006
Pregnancy, function contraindication 289908002
Hypertriglyceridemia contraindication 302870006
Osteopenia contraindication 312894000
Functional visual loss contraindication 313165001
Malignant tumor of ovary contraindication 363443007 DOID:2394
Thromboembolic disorder contraindication 371039008
Cardiovascular event risk contraindication 395112001
Disorder of coronary artery contraindication 414024009
Obesity contraindication 414916001 DOID:9970
Estrogen receptor positive tumor contraindication 416053008
Family history of malignant neoplasm of breast contraindication 429740004
Hypertensive urgency contraindication 443482000
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Progesterone receptor Nuclear hormone receptor AGONIST EC50 9.59 WOMBAT-PK CHEMBL
Glucocorticoid receptor Nuclear hormone receptor Ki 7.88 CHEMBL
Mineralocorticoid receptor Nuclear hormone receptor IC50 5.92 CHEMBL
Androgen receptor Nuclear hormone receptor EC50 8.20 WOMBAT-PK
Aldo-keto reductase family 1 member C1 Enzyme IC50 5.74 CHEMBL
Aldo-keto reductase family 1 member C2 Enzyme IC50 5.39 CHEMBL
Aldo-keto reductase family 1 member C3 Enzyme IC50 6.52 CHEMBL
Cytochrome P450 2C19 Enzyme IC50 5.70 DRUG MATRIX
Sex hormone-binding globulin Secreted Kd 6.20 CHEMBL
Histamine H2 receptor GPCR Ki 4.56 DRUG MATRIX
Estrogen receptor Nuclear hormone receptor IC50 6.03 CHEMBL
Androgen receptor Transcription factor IC50 7.45 CHEMBL
Progesterone receptor Transcription factor Ki 7.03 DRUG MATRIX
Androgen receptor Transcription factor EC50 8.21 CHEMBL

External reference:

IDSource
4019810 VUID
N0000147899 NUI
D00951 KEGG_DRUG
4017828 VANDF
4019810 VANDF
C0025147 UMLSCUI
CHEBI:6715 CHEBI
CHEMBL717 ChEMBL_ID
D008525 MESH_DESCRIPTOR_UI
10631 PUBCHEM_CID
2879 IUPHAR_LIGAND_ID
853 INN_ID
HSU1C9YRES UNII
DB00603 DRUGBANK_ID
1000112 RXNORM
5032 MMSL
7121 MMSL
d00284 MMSL
001295 NDDF
004938 NDDF
126112002 SNOMEDCT_US
126113007 SNOMEDCT_US
36621009 SNOMEDCT_US
D017258 MESH_DESCRIPTOR_UI
520-85-4 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-0050 TABLET 10 mg ORAL NDA 25 sections
Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-0051 TABLET 10 mg ORAL NDA 25 sections
Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-0064 TABLET 2.50 mg ORAL NDA 25 sections
Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-0065 TABLET 2.50 mg ORAL NDA 25 sections
Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-0286 TABLET 5 mg ORAL NDA 25 sections
Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-0287 TABLET 5 mg ORAL NDA 25 sections
Depo-Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-0746 INJECTION, SUSPENSION 150 mg INTRAMUSCULAR NDA 29 sections
Depo-SubQ Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-4709 INJECTION, SUSPENSION 104 mg SUBCUTANEOUS NDA 30 sections
Depo-Provera HUMAN PRESCRIPTION DRUG LABEL 1 0009-7376 INJECTION, SUSPENSION 150 mg INTRAMUSCULAR NDA 29 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1105 TABLET, SUGAR COATED 1.50 mg ORAL NDA 30 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1105 TABLET, SUGAR COATED 1.50 mg ORAL NDA 30 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1106 TABLET, SUGAR COATED 1.50 mg ORAL NDA 30 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1106 TABLET, SUGAR COATED 1.50 mg ORAL NDA 30 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1107 TABLET, SUGAR COATED 2.50 mg ORAL NDA 30 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1107 TABLET, SUGAR COATED 2.50 mg ORAL NDA 30 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1108 TABLET, SUGAR COATED 5 mg ORAL NDA 30 sections
Prempro HUMAN PRESCRIPTION DRUG LABEL 2 0046-1108 TABLET, SUGAR COATED 5 mg ORAL NDA 30 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0548-5400 INJECTION, SUSPENSION, EXTENDED RELEASE 150 mg INTRAMUSCULAR ANDA 29 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0548-5410 INJECTION, SUSPENSION, EXTENDED RELEASE 150 mg INTRAMUSCULAR ANDA 29 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0548-5410 INJECTION, SUSPENSION, EXTENDED RELEASE 150 mg INTRAMUSCULAR ANDA 29 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0548-5701 INJECTION, SUSPENSION, EXTENDED RELEASE 150 mg INTRAMUSCULAR ANDA 29 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0548-5711 INJECTION, SUSPENSION, EXTENDED RELEASE 150 mg INTRAMUSCULAR ANDA 29 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0548-5711 INJECTION, SUSPENSION, EXTENDED RELEASE 150 mg INTRAMUSCULAR ANDA 29 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0555-0779 TABLET 10 mg ORAL ANDA 24 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0555-0872 TABLET 2.50 mg ORAL ANDA 24 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0555-0873 TABLET 5 mg ORAL ANDA 24 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0703-6801 INJECTION, SUSPENSION 150 mg INTRAMUSCULAR ANDA 29 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0703-6801 INJECTION, SUSPENSION 150 mg INTRAMUSCULAR ANDA 29 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 10544-001 TABLET 5 mg ORAL ANDA 24 sections
Medroxyprogesterone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 10544-062 TABLET 10 mg ORAL ANDA 24 sections