chlormadinone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
600 302-22-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • chlormadinone
  • chlormadinone acetate
  • chlormadinon
  • chlormadinon acetate
  • menstridyl
An orally active synthetic progestational hormone used often in combinations as an oral contraceptive (CONTRACEPTIVES, ORAL).
  • Molecular weight: 404.93
  • Formula: C23H29ClO4
  • CLOGP: 3.98
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 60.44
  • ALOGS: -5.41
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ulnar tunnel syndrome 90.71 39.39 9 356 9 46685688
Meningioma 73.61 39.39 14 351 3491 46682206

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC G03AA15 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, fixed combinations
ATC G03AB07 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
Progestogens and estrogens, sequential preparations
ATC G03DB06 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS
Pregnadien derivatives
ATC G03FB03 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
PROGESTOGENS AND ESTROGENS IN COMBINATION
Progestogens and estrogens, sequential preparations
MeSH PA D000726 Androgen Antagonists
MeSH PA D003270 Contraceptive Agents
MeSH PA D003271 Contraceptive Agents, Female
MeSH PA D000080066 Contraceptive Agents, Hormonal
MeSH PA D003278 Contraceptives, Oral, Hormonal
MeSH PA D003280 Contraceptives, Oral, Synthetic
MeSH PA D006727 Hormone Antagonists
MeSH PA D012102 Reproductive Control Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Endometriosis indication 129103003
Menorrhagia indication 386692008

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor Ki 7.76 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 5.52 DRUG MATRIX
Androgen receptor Transcription factor Ki 7.68 DRUG MATRIX
Sodium/potassium-transporting ATPase subunit alpha-2 Ion channel IC50 5.34 DRUG MATRIX
Progesterone receptor Transcription factor Ki 9.16 DRUG MATRIX

External reference:

IDSource
D01299 KEGG_DRUG
1961-77-9 SECONDARY_CAS_RN
C0008214 UMLSCUI
CHEBI:31394 CHEBI
CHEMBL110691 ChEMBL_ID
CHEMBL1697830 ChEMBL_ID
DB13528 DRUGBANK_ID
DB15903 DRUGBANK_ID
D002715 MESH_DESCRIPTOR_UI
5284533 PUBCHEM_CID
1210 INN_ID
SDS4N642GG UNII
2369 RXNORM
001294 NDDF
004937 NDDF
734645001 SNOMEDCT_US
734647009 SNOMEDCT_US

Pharmaceutical products:

None